TY - JOUR T1 - Human P2Y sub(6) Receptor: Molecular Modeling Leads to the Rational Design of a Novel Agonist Based on a Unique Conformational Preference AN - 19387457; 7158854 AB - Combining molecular dynamics (MD) in a hydrated phospholipid (DOPC) bilayer, a Monte Carlo search, and synthesis of locked nucleotide analogues, we discovered that the Southern conformation of the ribose is preferred for ligand recognition by the P2Y sub(6) receptor. 2'-Deoxy-(S)-methanocarbaUDP was found to be a full agonist of the receptor and displayed a 10-fold higher potency than that for the corresponding flexible 2'-deoxyUDP. MD results also suggested a conformational change of the second extracellular loop consequent to agonist binding. JF - Journal of Medicinal Chemistry AU - Costanzi, S AU - Joshi, B V AU - Maddileti, S AU - Mamedova, L AU - Gonzalez-Moa, MJ AU - Marquez, V E AU - Harden, T K AU - Jacobson, KA AD - Computational Chemistry Core Laboratory and Molecular Recognition Section, NIDDK, National Institutes of Health, DHHS, Bethesda, Maryland 20892, USA Y1 - 2005/12/29/ PY - 2005 DA - 2005 Dec 29 SP - 8108 EP - 8111 VL - 48 IS - 26 SN - 0022-2623, 0022-2623 KW - Biotechnology and Bioengineering Abstracts KW - Molecular modelling KW - Ribose KW - Purine P2Y receptors KW - Nucleotide analogs KW - Phospholipids KW - Conformation KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19387457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medicinal+Chemistry&rft.atitle=Human+P2Y+sub%286%29+Receptor%3A+Molecular+Modeling+Leads+to+the+Rational+Design+of+a+Novel+Agonist+Based+on+a+Unique+Conformational+Preference&rft.au=Costanzi%2C+S%3BJoshi%2C+B+V%3BMaddileti%2C+S%3BMamedova%2C+L%3BGonzalez-Moa%2C+MJ%3BMarquez%2C+V+E%3BHarden%2C+T+K%3BJacobson%2C+KA&rft.aulast=Costanzi&rft.aufirst=S&rft.date=2005-12-29&rft.volume=48&rft.issue=26&rft.spage=8108&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medicinal+Chemistry&rft.issn=00222623&rft_id=info:doi/10.1021%2Fjm050911p LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Nucleotide analogs; Purine P2Y receptors; Conformation; Ribose; Phospholipids; Molecular modelling DO - http://dx.doi.org/10.1021/jm050911p ER - TY - JOUR T1 - Semirational Design of (North)-Methanocarba Nucleosides as Dual Acting A sub(1) and A sub(3) Adenosine Receptor Agonists: Novel Prototypes for Cardioprotection AN - 19386734; 7158853 AB - Ring-constrained adenosine analogues have been designed to act as dual agonists at tissue-protective A sub(1) and A sub(3) adenosine receptors (ARs). 9-Ribosides transformed into the ring-constrained (N)-methanocarba-2-chloro-5'-uronamides consistently lost affinity at A sub(1)/A sub(2A)ARs and gained at A sub(3)AR. Among 9-riboside derivatives, only N super(6)-cyclopentyl and 7-norbornyl moieties were extrapolated for mixed A sub(1)/A sub(3) selectivity and rat/human A sub(3)AR equipotency. Consequently, 2 was balanced in affinity and potency at A sub(1)/A sub(3)ARs as envisioned and dramatically protected in an intact heart model of global ischemia and reperfusion. JF - Journal of Medicinal Chemistry AU - Jacobson, KA AU - Gao, Z-G AU - Tchilibon, S AU - Duong, H T AU - Joshi, B V AU - Sonin, D AU - Liang, B T AD - Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2005/12/29/ PY - 2005 DA - 2005 Dec 29 SP - 8103 EP - 8107 VL - 48 IS - 26 SN - 0022-2623, 0022-2623 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Reperfusion KW - Adenosine receptors KW - nucleosides KW - Ischemia KW - Models KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19386734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medicinal+Chemistry&rft.atitle=Semirational+Design+of+%28North%29-Methanocarba+Nucleosides+as+Dual+Acting+A+sub%281%29+and+A+sub%283%29+Adenosine+Receptor+Agonists%3A+Novel+Prototypes+for+Cardioprotection&rft.au=Jacobson%2C+KA%3BGao%2C+Z-G%3BTchilibon%2C+S%3BDuong%2C+H+T%3BJoshi%2C+B+V%3BSonin%2C+D%3BLiang%2C+B+T&rft.aulast=Jacobson&rft.aufirst=KA&rft.date=2005-12-29&rft.volume=48&rft.issue=26&rft.spage=8103&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medicinal+Chemistry&rft.issn=00222623&rft_id=info:doi/10.1021%2Fjm050726b LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Adenosine receptors; Ischemia; Reperfusion; Heart; nucleosides; Models DO - http://dx.doi.org/10.1021/jm050726b ER - TY - JOUR T1 - Antifungal Flavonoids from Hildegardia barteri AN - 19829804; 6674756 AB - A new isoflavan, (3R)-6,2'-dihydroxy-7-methoxy-4',5'-methylenedioxyisoflavan, hildegardiol (1), and two known flavonoids, 2-hydroxymaackiain (2) and farrerol (3), were isolated from the antifungal root extract of Hildegardia barteri. The pterocarpan 2 was largely responsible for the observed antifungal activity. JF - Journal of Natural Products AU - Meragelman, T L AU - Tucker, K D AU - McCloud, T G AU - Cardellina, JH II AU - Shoemaker, R H AD - Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, and SAIC-Frederick, Inc., National Cancer Institute-Frederick, Frederick, Maryland 21702-1201, USA Y1 - 2005/12/26/ PY - 2005 DA - 2005 Dec 26 SP - 1790 EP - 1792 VL - 68 IS - 12 SN - 0163-3864, 0163-3864 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Flavonoids KW - Antifungal activity KW - Roots KW - natural products KW - K 03340:Effects of Physical & Chemical Factors KW - A 01067:Antifungal & fungicidal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19829804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Natural+Products&rft.atitle=Antifungal+Flavonoids+from+Hildegardia+barteri&rft.au=Meragelman%2C+T+L%3BTucker%2C+K+D%3BMcCloud%2C+T+G%3BCardellina%2C+JH+II%3BShoemaker%2C+R+H&rft.aulast=Meragelman&rft.aufirst=T&rft.date=2005-12-26&rft.volume=68&rft.issue=12&rft.spage=1790&rft.isbn=&rft.btitle=&rft.title=Journal+of+Natural+Products&rft.issn=01633864&rft_id=info:doi/10.1021%2Fnp0503000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Flavonoids; Antifungal activity; Roots; natural products DO - http://dx.doi.org/10.1021/np0503000 ER - TY - JOUR T1 - Hormonal contraceptive use, pregnancy and parity, and the risk of cervical intraepithelial neoplasia 3 among oncogenic HPV DNA-positive women with equivocal or mildly abnormal cytology. AN - 68731855; 15986443 AB - Oral contraceptive (OC) use, hormonal contraceptive use and multiparity are potential risk factors for cervical precancer, cervical intraepithelial neoplasia 3 (CIN3), but a limited number of studies have adequately accounted for possible confounding effect of oncogenic human papillomavirus (HPV) infection. To examine the relationships of these factors with CIN3, we conducted an analysis of women (n = 5,060) with minimally abnormal Pap smears who were enrolled in the ASCUS and LSIL Triage Study (ALTS), a clinical trial to evaluate management strategies. Cervical specimens collected at enrollment were tested for HPV DNA using 2 methods. Multivariate logistics regression models were used to assess associations (odds ratio [OR] with 95% confidence intervals [CI]) of the potential risk factors (e.g., OC use and parity) with testing oncogenic HPV positive among controls ( or =7). Total, red, or white meat intake was not associated with prostate cancer risk. More than 10 g/d of very well done meat, compared with no consumption, was associated with a 1.4-fold increased risk of prostate cancer [95% confidence interval (95% CI), 1.05-1.92] and a 1.7-fold increased risk (95% CI, 1.19-2.40) of incident disease. Although there was no association with MeIQx and DiMeIQx, the highest quintile of PhIP was associated with a 1.2-fold increased risk of prostate cancer (95% CI, 1.01-1.48) and a 1.3-fold increased risk of incident disease (95% CI, 1.01-1.61). In conclusion, very well done meat was positively associated with prostate cancer risk. In addition, this study lends epidemiologic support to the animal studies, which have implicated PhIP as a prostate carcinogen. JF - Cancer research AU - Cross, Amanda J AU - Peters, Ulrike AU - Kirsh, Victoria A AU - Andriole, Gerald L AU - Reding, Douglas AU - Hayes, Richard B AU - Sinha, Rashmi AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA. crossa@mail.nih.gov Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 SP - 11779 EP - 11784 VL - 65 IS - 24 SN - 0008-5472, 0008-5472 KW - Imidazoles KW - 0 KW - Mutagens KW - Quinoxalines KW - Benzo(a)pyrene KW - 3417WMA06D KW - 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline KW - 77500-04-0 KW - 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine KW - 909C6UN66T KW - 3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine KW - YRA7G7WU6P KW - Index Medicus KW - Quinoxalines -- chemistry KW - Quinoxalines -- adverse effects KW - Prospective Studies KW - Risk Factors KW - Humans KW - Surveys and Questionnaires KW - Benzo(a)pyrene -- chemistry KW - Aged KW - Middle Aged KW - Benzo(a)pyrene -- adverse effects KW - Male KW - Imidazoles -- adverse effects KW - Imidazoles -- chemistry KW - Prostatic Neoplasms -- etiology KW - Meat KW - Prostatic Neoplasms -- epidemiology KW - Mutagens -- adverse effects KW - Cooking KW - Diet KW - Mutagens -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68900059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=A+prospective+study+of+meat+and+meat+mutagens+and+prostate+cancer+risk.&rft.au=Cross%2C+Amanda+J%3BPeters%2C+Ulrike%3BKirsh%2C+Victoria+A%3BAndriole%2C+Gerald+L%3BReding%2C+Douglas%3BHayes%2C+Richard+B%3BSinha%2C+Rashmi&rft.aulast=Cross&rft.aufirst=Amanda&rft.date=2005-12-15&rft.volume=65&rft.issue=24&rft.spage=11779&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-23 N1 - Date created - 2005-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Upregulation of estrogen receptor expression in the uterus of ovariectomized B6C3F1 mice and Ishikawa cells treated with bromoethane. AN - 68865104; 15922381 AB - In a 2-year NTP bioassay, Bromoethane (BE) was found to induce endometrial neoplasms in the uterus of B6C3F1 mice [; ]. In women, hormonal influences, such as "unopposed" estrogenic stimulus, have been implicated as important etiologic factors in uterine cancer. BE, however, does not affect the serum concentrations of sex hormones in female B6C3F1 mice [] and the mechanism of BE-induced uterine carcinogenesis still remains unclear. In the present study, we examined the estrogenic effects of BE on the uterus of ovariectomized B6C3F1 mice and on Ishikawa cells. Groups of 6 mice were given daily s.c. injections of 0, 100, 500 or 1000 mg BE/kg for 3 consecutive days. Mice treated with 17beta-estradiol served as positive controls. Mice were necropsied 24 h after the final injection, and uteri were weighed and examined histologically and immunohistochemically along with the vagina. Changes observed in the estrogen-treated mice included increased uterine weights, edema and inflammation of the endometrium, increased epithelial layers of the uterine and vaginal lumens and keratinization of the vaginal epithelium. In the BE-treated mice, no such changes occurred; however, immunohistochemical staining of the uterus revealed a significant increase in immunoexpression of the estrogen receptor alpha (ERalpha) in the two higher dose groups. Analysis of mRNA also showed slightly increased uterine ERalpha expression in these groups. Upregulated expression of ERalpha was confirmed in BE-treated Ishikawa cells, in which Western blotting analyses identified an intense signal at approximately 66 kDa, which is consistent with ERalpha. These data suggest that upregulated expression of ERalpha may be important in the induction of endometrial neoplasms in BE-treated mice. JF - Toxicology and applied pharmacology AU - Aoyama, Hiroaki AU - Couse, John F AU - Hewitt, Sylvia C AU - Haseman, Joseph K AU - He, Hong AU - Zheng, Xiaolin AU - Majstoravich, Sonja AU - Korach, Kenneth S AU - Dixon, D AD - Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, P.O. Box 12233, MD C2-09, Research Triangle Park, NC 27709, USA. Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 SP - 226 EP - 235 VL - 209 IS - 3 SN - 0041-008X, 0041-008X KW - Estrogen Receptor alpha KW - 0 KW - Hydrocarbons, Brominated KW - Proliferating Cell Nuclear Antigen KW - Estradiol KW - 4TI98Z838E KW - Hypoxanthine Phosphoribosyltransferase KW - EC 2.4.2.8 KW - Ribonucleases KW - EC 3.1.- KW - bromoethane KW - LI8384T9PH KW - Index Medicus KW - Animals KW - Endometritis -- chemically induced KW - Ribonucleases -- antagonists & inhibitors KW - Dose-Response Relationship, Drug KW - Estradiol -- pharmacology KW - Hypoxanthine Phosphoribosyltransferase -- metabolism KW - Proliferating Cell Nuclear Antigen -- analysis KW - Mice KW - Cell Line, Tumor KW - Ribonucleases -- metabolism KW - Mice, Inbred Strains KW - Blotting, Western KW - Endometrium -- drug effects KW - Up-Regulation -- drug effects KW - Endometrium -- chemistry KW - Injections, Subcutaneous KW - Endometrium -- pathology KW - Immunochemistry -- methods KW - Endometritis -- pathology KW - Female KW - Organ Size -- drug effects KW - Uterus -- metabolism KW - Estrogen Receptor alpha -- biosynthesis KW - Hydrocarbons, Brominated -- administration & dosage KW - Ovariectomy KW - Uterus -- drug effects KW - Hydrocarbons, Brominated -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68865104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Upregulation+of+estrogen+receptor+expression+in+the+uterus+of+ovariectomized+B6C3F1+mice+and+Ishikawa+cells+treated+with+bromoethane.&rft.au=Aoyama%2C+Hiroaki%3BCouse%2C+John+F%3BHewitt%2C+Sylvia+C%3BHaseman%2C+Joseph+K%3BHe%2C+Hong%3BZheng%2C+Xiaolin%3BMajstoravich%2C+Sonja%3BKorach%2C+Kenneth+S%3BDixon%2C+D&rft.aulast=Aoyama&rft.aufirst=Hiroaki&rft.date=2005-12-15&rft.volume=209&rft.issue=3&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-17 N1 - Date created - 2005-12-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prednisolone pharmacokinetics in the presence and absence of ritonavir after oral prednisone administration to healthy volunteers. AN - 68796678; 16284534 AB - Corticosteroid therapy has been associated with bone toxicities (eg, osteonecrosis) and Cushing syndrome in HIV-infected patients; this may be partially attributable to a pharmacokinetic drug interaction between HIV protease inhibitors and corticosteroids. The purpose of this study was to characterize the influence of low-dose ritonavir on prednisolone pharmacokinetics in healthy subjects. Ten HIV-seronegative volunteers were given single oral doses of prednisone, 20 mg, before (baseline) and after receiving ritonavir, 200 mg, twice daily for 4 and 14 days. After each prednisone dose, serial blood samples were collected and prednisolone concentrations were determined; pharmacokinetic parameter values were compared between the groups. Geometric mean ratios (GMRs, 90% confidence interval [CI]) of the prednisolone area under the plasma concentration versus time curve (AUC0-infinity) after 4 and 14 days of ritonavir versus baseline were 1.41 (90% CI: 1.08 to 1.74) and 1.30 (90% CI: 1.09 to 1.49), respectively (P = 0.002 and P = 0.004, respectively). GMRs of prednisolone apparent oral clearance (Cl/F) were 0.71 (09% CI: 0.57 to 0.93) and 0.77 (90% CI: 0.67 to 0.92) after 4 and 14 days of ritonavir versus baseline, respectively (P = 0.0004 and P = 0.0003, respectively). Ritonavir significantly increased the systemic exposure of prednisolone in healthy subjects. Results from this investigation suggest that corticosteroid exposure is likely elevated in HIV-infected patients receiving protease inhibitors. JF - Journal of acquired immune deficiency syndromes (1999) AU - Penzak, Scott R AU - Formentini, Elizabeth AU - Alfaro, Raul M AU - Long, Michael AU - Natarajan, Ven AU - Kovacs, Joseph AD - Warren G. Magnuson Clinical Center, Pharmacy Department, National Institutes of Health, Bethesda, MD 20892, USA. Spenzak@mail.cc.nih.gov Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 SP - 573 EP - 580 VL - 40 IS - 5 SN - 1525-4135, 1525-4135 KW - Glucocorticoids KW - 0 KW - HIV Protease Inhibitors KW - Prednisolone KW - 9PHQ9Y1OLM KW - Ritonavir KW - O3J8G9O825 KW - Index Medicus KW - AIDS/HIV KW - Drug Interactions KW - Area Under Curve KW - Humans KW - Adult KW - HIV Seronegativity KW - Male KW - Female KW - Prednisolone -- pharmacokinetics KW - Glucocorticoids -- pharmacokinetics KW - Ritonavir -- pharmacokinetics KW - Ritonavir -- pharmacology KW - Glucocorticoids -- administration & dosage KW - Ritonavir -- administration & dosage KW - HIV Protease Inhibitors -- pharmacology KW - HIV Protease Inhibitors -- pharmacokinetics KW - Prednisolone -- administration & dosage KW - HIV Protease Inhibitors -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68796678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.atitle=Prednisolone+pharmacokinetics+in+the+presence+and+absence+of+ritonavir+after+oral+prednisone+administration+to+healthy+volunteers.&rft.au=Penzak%2C+Scott+R%3BFormentini%2C+Elizabeth%3BAlfaro%2C+Raul+M%3BLong%2C+Michael%3BNatarajan%2C+Ven%3BKovacs%2C+Joseph&rft.aulast=Penzak&rft.aufirst=Scott&rft.date=2005-12-15&rft.volume=40&rft.issue=5&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.issn=15254135&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-23 N1 - Date created - 2005-11-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Uptake and Trafficking of Exogenous Sterol in Saccharomyces Cerevisiae T2 - 2005 Biochemical Society Focused Meeting on Non-Vesicular Intracellular Traffic AN - 39824813; 4040165 JF - 2005 Biochemical Society Focused Meeting on Non-Vesicular Intracellular Traffic AU - Prinz, Will Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Sterols KW - Saccharomyces cerevisiae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39824813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+consulting+and+clinical+psychology&rft.atitle=A+new+tool+to+assess+treatment+fidelity+and+evaluation+of+treatment+fidelity+across+10+years+of+health+behavior+research&rft.au=Borrelli%2C+Belinda%3BSepinwall%2C+Deborah%3BErnst%2C+Denise%3BBellg%2C+Albert+J%3BCzajkowski%2C+Susan%3BBreger%2C+Rosemary%3BDeFrancesco%2C+Carol%3BLevesque%2C+Chantal%3BSharp%2C+Daryl+L%3BOgedegbe%2C+Gbenga%3BResnick%2C+Barbara%3BOrwig%2C+Denise&rft.aulast=Borrelli&rft.aufirst=Belinda&rft.date=2005-10-01&rft.volume=73&rft.issue=5&rft.spage=852&rft.isbn=&rft.btitle=&rft.title=Journal+of+consulting+and+clinical+psychology&rft.issn=0022006X&rft_id=info:doi/10.1037%2F0022-006X.73.5.852 L2 - http://www.biochemistry.org/meetings/programme.cfm?Meeting_No=SA053 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Amazing Versatility of Proteins - Structural Polymorphism and Evolution T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39823201; 4060133 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Gronenborn, A M AU - Byeon, I L AU - Louis, J M Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Gene polymorphism KW - Evolution KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39823201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=The+Amazing+Versatility+of+Proteins+-+Structural+Polymorphism+and+Evolution&rft.au=Gronenborn%2C+A+M%3BByeon%2C+I+L%3BLouis%2C+J+M&rft.aulast=Gronenborn&rft.aufirst=A&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Direct Effects of Ionizing Radiation on Supercoiled Plasmid DNA T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39808881; 4060927 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Kempner, E S AU - Anchordoquy, T AU - Molina, M Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Ionizing radiation KW - Plasmids KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39808881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Direct+Effects+of+Ionizing+Radiation+on+Supercoiled+Plasmid+DNA&rft.au=Kempner%2C+E+S%3BAnchordoquy%2C+T%3BMolina%2C+M&rft.aulast=Kempner&rft.aufirst=E&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Solution Structure of the Phosphoryl Transfer Complex Between the Cytoplasmic A Domain and B Domain of the Mannitol Transporter II: Mannitol of the E. Coli Phosphotransferase System T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39808578; 4058040 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Suh, J AU - Cai, M AU - Williams Jr, D AU - Clore, M Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Mannitol KW - Phosphotransferase KW - Escherichia coli KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39808578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Solution+Structure+of+the+Phosphoryl+Transfer+Complex+Between+the+Cytoplasmic+A+Domain+and+B+Domain+of+the+Mannitol+Transporter+II%3A+Mannitol+of+the+E.+Coli+Phosphotransferase+System&rft.au=Suh%2C+J%3BCai%2C+M%3BWilliams+Jr%2C+D%3BClore%2C+M&rft.aulast=Suh&rft.aufirst=J&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Continued Importance of Medicinal Plants and International Collaboration in the Discovery of Novel Drug Leads T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39806338; 4064226 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Cragg, G M Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Medicinal plants KW - Drug discovery KW - Lead KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39806338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Continued+Importance+of+Medicinal+Plants+and+International+Collaboration+in+the+Discovery+of+Novel+Drug+Leads&rft.au=Cragg%2C+G+M&rft.aulast=Cragg&rft.aufirst=G&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Visualizing Structural Dynamics in Proteins withPicosecond Time-Resolved Laue Crystallography T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39784870; 4064466 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Anfinrud, P AU - Schotte, F AU - Hummer, G AU - Wulff, M Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Crystallography KW - Structural dynamics KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39784870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Visualizing+Structural+Dynamics+in+Proteins+withPicosecond+Time-Resolved+Laue+Crystallography&rft.au=Anfinrud%2C+P%3BSchotte%2C+F%3BHummer%2C+G%3BWulff%2C+M&rft.aulast=Anfinrud&rft.aufirst=P&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chromatographic Chiral Recognition on Immobilized Cellular Membrane-based Stationary Phase: The Enantioselective Binding of Noncompetitive Inhibitors to Neuronal Nicotinic Acetylcholine Receptors T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39780037; 4059238 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Wainer, I W Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Acetylcholine receptors (nicotinic) KW - Stationary phase KW - Neurotransmitters KW - Inhibitors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39780037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Chromatographic+Chiral+Recognition+on+Immobilized+Cellular+Membrane-based+Stationary+Phase%3A+The+Enantioselective+Binding+of+Noncompetitive+Inhibitors+to+Neuronal+Nicotinic+Acetylcholine+Receptors&rft.au=Tarran%2C+Robert%3BButton%2C+Brian%3BPicher%2C+Maryse%3BParadiso%2C+Anthony+M%3BRibeiro%2C+Carla+M%3BLazarowski%2C+Eduardo+R%3BZhang%2C+Liqun%3BCollins%2C+Peter+L%3BPickles%2C+Raymond+J%3BFredberg%2C+Jeffrey+J%3BBoucher%2C+Richard+C&rft.aulast=Tarran&rft.aufirst=Robert&rft.date=2005-10-01&rft.volume=280&rft.issue=42&rft.spage=35751&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NIH Dietary Supplements Methods and Reference Materials Program T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39777812; 4058646 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Betz, J M Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Dietary supplements KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39777812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=NIH+Dietary+Supplements+Methods+and+Reference+Materials+Program&rft.au=Betz%2C+J+M&rft.aulast=Betz&rft.aufirst=J&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recent Developments with Anti-HIV Cyclotides and Other Naturally Occurring Cyclized Peptides" T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39775900; 4060136 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Gustafson, K Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Peptides KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39775900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Recent+Developments+with+Anti-HIV+Cyclotides+and+Other+Naturally+Occurring+Cyclized+Peptides%22&rft.au=Gustafson%2C+K&rft.aulast=Gustafson&rft.aufirst=K&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of an Open Tubular Column Containing Immobilized P-glycoprotein with Caco-2 Cell Monolayers for the Identification of Pgp Substrates T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39773250; 4059052 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Wainer, I W AU - Moaddel, R AU - Bullock, P Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - P-Glycoprotein KW - Monomolecular films KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39773250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Comparison+of+an+Open+Tubular+Column+Containing+Immobilized+P-glycoprotein+with+Caco-2+Cell+Monolayers+for+the+Identification+of+Pgp+Substrates&rft.au=Wainer%2C+I+W%3BMoaddel%2C+R%3BBullock%2C+P&rft.aulast=Wainer&rft.aufirst=I&rft.date=2005-12-15&rft.volume=187&rft.issue=20&rft.spage=7081&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV-1 Integrase Inhibitor Development Based on Model of Full-Length HIV-1 Integrase Complexed with Viral DNA T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39772741; 4059646 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Nicklaus, M C AU - Karki, R G Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Integrase KW - Models KW - Inhibitors KW - Human immunodeficiency virus 1 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39772741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=HIV-1+Integrase+Inhibitor+Development+Based+on+Model+of+Full-Length+HIV-1+Integrase+Complexed+with+Viral+DNA&rft.au=Nicklaus%2C+M+C%3BKarki%2C+R+G&rft.aulast=Nicklaus&rft.aufirst=M&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Molecular Target Modulating Metabolites from Marine Sponges and Bryozoans T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39769995; 4063612 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Gustafson, K AU - Oku, N AU - Milanowski, D AU - McMahon, J Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Porifera KW - Metabolites KW - Marine invertebrates KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39769995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=New+Molecular+Target+Modulating+Metabolites+from+Marine+Sponges+and+Bryozoans&rft.au=Gustafson%2C+K%3BOku%2C+N%3BMilanowski%2C+D%3BMcMahon%2C+J&rft.aulast=Gustafson&rft.aufirst=K&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chemotherapeutic Potentiation of Targeted a-Particle Therapy T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39764645; 4067400 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Brechbiel, M AU - Milenic, D AU - Garmestani, K AU - Abdulla, A AU - Overstreet, T Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Potentiation KW - Therapy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39764645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Chemotherapeutic+Potentiation+of+Targeted+a-Particle+Therapy&rft.au=Brechbiel%2C+M%3BMilenic%2C+D%3BGarmestani%2C+K%3BAbdulla%2C+A%3BOverstreet%2C+T&rft.aulast=Brechbiel&rft.aufirst=M&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Value of Natural Products as Leads to Drug Candidates T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39762796; 4058002 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Newman, D J Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Drugs KW - Natural products KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39762796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Value+of+Natural+Products+as+Leads+to+Drug+Candidates&rft.au=Newman%2C+D+J&rft.aulast=Newman&rft.aufirst=D&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structure, Dynamics and Function of Water in Hydrophobic Confinement T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39757041; 4065375 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Hummer, G Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Structure-function relationships KW - Hydrophobicity KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39757041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Structure%2C+Dynamics+and+Function+of+Water+in+Hydrophobic+Confinement&rft.au=Hummer%2C+G&rft.aulast=Hummer&rft.aufirst=G&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Marine Natural Products in Current Screening Approaches at the National Cancer Institute T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39754226; 4063037 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Cardellina, J H AU - Scudiero, D A AU - McCloud, T G AU - Shoemaker, R H Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Cancer KW - Natural products KW - Screening KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39754226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Marine+Natural+Products+in+Current+Screening+Approaches+at+the+National+Cancer+Institute&rft.au=Cardellina%2C+J+H%3BScudiero%2C+D+A%3BMcCloud%2C+T+G%3BShoemaker%2C+R+H&rft.aulast=Cardellina&rft.aufirst=J&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Examining Reaction Processes in Macromolecular Systems T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39746039; 4065634 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Woodcock, H L AU - Hodoscek, M AU - Brooks, B R Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Macromolecules KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39746039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Examining+Reaction+Processes+in+Macromolecular+Systems&rft.au=Woodcock%2C+H+L%3BHodoscek%2C+M%3BBrooks%2C+B+R&rft.aulast=Woodcock&rft.aufirst=H&rft.date=2005-12-15&rft.volume=&rft.issue=19&rft.spage=6862&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fish are Contaminated with Mercury and PCBs: Collaborating with the Hmong Community in Milwaukee to Communicate the Risks and Benefits of Local Fish Consumption T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39721561; 4058648 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Petering, D H AU - Kiatousaysy, L AU - McAvoy, P AU - Rostenkowski, A AU - Weber, D AU - Gallun, T AU - Dellinger, J AU - Driscoll, M AU - Percy, S Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - USA, Wisconsin, Milwaukee KW - Pisces KW - Heavy metals KW - Mercury KW - PCB KW - Polychlorinated biphenyls KW - Fish consumption KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39721561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Fish+are+Contaminated+with+Mercury+and+PCBs%3A+Collaborating+with+the+Hmong+Community+in+Milwaukee+to+Communicate+the+Risks+and+Benefits+of+Local+Fish+Consumption&rft.au=Petering%2C+D+H%3BKiatousaysy%2C+L%3BMcAvoy%2C+P%3BRostenkowski%2C+A%3BWeber%2C+D%3BGallun%2C+T%3BDellinger%2C+J%3BDriscoll%2C+M%3BPercy%2C+S&rft.aulast=Petering&rft.aufirst=D&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Weak Alignment Offers New Opportunities in NMR Structure Determination T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39720494; 4059971 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Bax, A AU - Grishaev, A AU - Bryce, D AU - Jaroniec, C AU - Wu, J. AU - Baber, J AU - Ulmer, T AU - Delaglio, F Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - N.M.R. KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39720494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Weak+Alignment+Offers+New+Opportunities+in+NMR+Structure+Determination&rft.au=Bax%2C+A%3BGrishaev%2C+A%3BBryce%2C+D%3BJaroniec%2C+C%3BWu%2C+J.%3BBaber%2C+J%3BUlmer%2C+T%3BDelaglio%2C+F&rft.aulast=Bax&rft.aufirst=A&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role and Value of Natural Products T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39719901; 4057895 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Newman, D J Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Natural products KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39719901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Role+of+RcsF+in+Signaling+to+the+Rcs+Phosphorelay+Pathway+in+Escherichia+coli&rft.au=Majdalani%2C+Nadim%3BHeck%2C+Michael%3BStout%2C+Valerie%3BGottesman%2C+Susan&rft.aulast=Majdalani&rft.aufirst=Nadim&rft.date=2005-10-01&rft.volume=187&rft.issue=19&rft.spage=6770&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanism of Sonodynamic Therapy of Cancer Cells T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39711926; 4059452 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Miyoshi, N AU - Sostaric, J Z AU - Tuziuti, T AU - Kyuichi, Y AU - Iida, Y AU - Peter, R Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Cancer KW - Therapy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39711926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Mechanism+of+Sonodynamic+Therapy+of+Cancer+Cells&rft.au=Miyoshi%2C+N%3BSostaric%2C+J+Z%3BTuziuti%2C+T%3BKyuichi%2C+Y%3BIida%2C+Y%3BPeter%2C+R&rft.aulast=Miyoshi&rft.aufirst=N&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Marine Natural Products: Inhibitors in Infectious Diseases T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39708302; 4063044 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Bewley, C Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Infectious diseases KW - Natural products KW - Inhibitors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39708302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Marine+Natural+Products%3A+Inhibitors+in+Infectious+Diseases&rft.au=Bewley%2C+C&rft.aulast=Bewley&rft.aufirst=C&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Progress and New Directions in Genetics of Tuberculosis: An NHLBI Working Group Report AN - 199606419; 16192449 AB - Tuberculosis (TB), along with AIDS and malaria, is one of the three major killers among infectious diseases. New approaches to preventing, diagnosing, and curing TB are needed, which depend on a better understanding of Mycobacterium tuberculosis and the host. The National Heart, Lung, and Blood Institute convened a working group to develop recommendations for future TB research, including genetic aspects of the disease. The following areas were identified: (1) animal model research to improve understanding of persistence, reactivation, and granulomatous reactions; (2) preclinical studies aimed at shortening treatment of TB; (3) new resources for manipulating and characterizing the M. tuberculosis genome, proteome chips for more specific diagnoses, and studies of genes that appear to be essential but whose functions are not known; (4) prospective studies associated with clinical trials in populations with or at risk of TB to advance development of diagnostics and prognostics; (5) new quantitative and bioinformatic approaches to study the interaction between M. tuberculosis and the infected host and how this influences the infection process; (6) molecular characterization of M. tuberculosis genome diversity and phylogenetic analysis; (7) coordinated studies of human genome scans; (8) genetic epidemiology studies; (9) activities to foster knowledge dissemination, education, and training; and (10) coordination between the National Institutes of Health, the Gates Foundation, the Global Alliance for Tuberculosis Drug Development, and other organizations. JF - American Journal of Respiratory and Critical Care Medicine AU - Smith, Issar AU - Nathan, Carl AU - Peavy, Hannah H Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 SP - 1491 EP - 6 CY - New York PB - American Thoracic Society VL - 172 IS - 12 SN - 1073449X KW - Medical Sciences--Respiratory Diseases KW - Animals KW - Tuberculosis -- therapy KW - Humans KW - Tuberculosis -- physiopathology KW - Biomedical Research -- trends KW - Tuberculosis -- genetics KW - Mycobacterium tuberculosis -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/199606419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Progress+and+New+Directions+in+Genetics+of+Tuberculosis%3A+An+NHLBI+Working+Group+Report&rft.au=Smith%2C+Issar%3BNathan%2C+Carl%3BPeavy%2C+Hannah+H&rft.aulast=Smith&rft.aufirst=Issar&rft.date=2005-12-15&rft.volume=172&rft.issue=12&rft.spage=1491&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Thoracic Society Dec 15, 2005 N1 - Last updated - 2017-01-07 ER - TY - JOUR T1 - Biological, cellular, and molecular characteristics of an inducible transgenic skin tumor model: a review AN - 19742040; 6687887 AB - The genetically initiated Tg.AC transgenic mouse carries a transgene consisting of an oncogenic v-Ha-ras coding region flanked 5' by a mouse xi -globin promoter and 3' by an SV-40 polyadenylation sequence. Located on chromosome 11, the transgene is transcriptionally silent until activated by chemical carcinogens, UV light, or full-thickness wounding. Expression of the transgene is an early event that drives cellular proliferation resulting in clonal expansion and tumor formation, the unique characteristics now associated with the Tg.AC mouse. This ras-dependent phenotype has resulted in the widespread interest and use of the Tg.AC mouse in experimental skin carcinogenesis and as an alternative carcinogenesis assay. This review examines the general biology of the tumorigenic responses observed in Tg.AC mice, the genetic interactions of the ras transgene, and explores the cellular and molecular regulation of xi -globin promoted transgene expression. As a prototype alternative model to the current long-term rodent bioassays, the Tg.AC has generated a healthy discussion on the future of transgenic bioassays, and opened the doors for subsequent models for toxicity testing. The further exploration and elucidation of the molecular controls of transgene expression will enhance the usefulness of this mouse and enable a better understanding of the Tg. AC's discriminate response to chemical carcinogens. JF - Oncogene AU - Humble, M C AU - Trempus, C S AU - Spalding, J W AU - Cannon, R E AU - Tennant, R W AD - National Center for Toxicogenomics, National Institute of Environmental Health Sciences, PO Box 12233, MD F1-05, 111 Alexander Drive, Research Triangle Park, NC 27709, USA Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 SP - 8217 EP - 8228 VL - 24 IS - 56 SN - 0950-9232, 0950-9232 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Oncogenes & Growth Factors Abstracts KW - Ras protein KW - chromosome 11 KW - Molecular modelling KW - Skin KW - Animal models KW - Skin cancer KW - Transcription KW - Polyadenylation KW - Carcinogens KW - Tumors KW - Transgenic mice KW - Promoters KW - Globins KW - U.V. radiation KW - Ha-Ras protein KW - Reviews KW - Carcinogenesis KW - Exploration KW - Toxicity testing KW - Wounding KW - W 30925:Genetic Engineering KW - B 26130:Ras and Ras related oncogenes (Rho/Rac/Ral) KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19742040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Biological%2C+cellular%2C+and+molecular+characteristics+of+an+inducible+transgenic+skin+tumor+model%3A+a+review&rft.au=Humble%2C+M+C%3BTrempus%2C+C+S%3BSpalding%2C+J+W%3BCannon%2C+R+E%3BTennant%2C+R+W&rft.aulast=Humble&rft.aufirst=M&rft.date=2005-12-15&rft.volume=24&rft.issue=56&rft.spage=8217&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/10.1038%2Fsj.onc.1209000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Ras protein; Molecular modelling; chromosome 11; Skin; Animal models; Transcription; Skin cancer; Polyadenylation; Tumors; Carcinogens; Transgenic mice; Globins; Promoters; U.V. radiation; Reviews; Ha-Ras protein; Carcinogenesis; Exploration; Toxicity testing; Wounding DO - http://dx.doi.org/10.1038/sj.onc.1209000 ER - TY - JOUR T1 - Cardiovascular phenotyping of fetal mice by noninvasive high-frequency ultrasound facilitates recovery of ENU-induced mutations causing congenital cardiac and extracardiac defects. AN - 68896708; 16174781 AB - As part of a large-scale noninvasive fetal ultrasound screen to recover ethylnitrosourea (ENU)-induced mutations causing congenital heart defects in mice, we established a high-throughput ultrasound scanning strategy for interrogating fetal mice in utero utilizing three orthogonal imaging planes defined by the fetus' vertebral column and body axes, structures readily seen by ultrasound. This contrasts with the difficulty of acquiring clinical ultrasound imaging planes which are defined by the fetal heart. By use of the three orthogonal imaging planes for two-dimensional (2D) imaging together with color flow, spectral Doppler, and M-mode imaging, all of the major elements of the heart can be evaluated. In this manner, 10,091 ENU-mutagenized mouse fetuses were ultrasound scanned between embryonic days 12.5 and 19.5, with 324 fetuses found to die prenatally and 425 exhibiting cardiovascular defects. Further analysis by necropsy and histology showed heart defects that included conotruncal anomalies, obstructive lesions, and shunt lesions as well as other complex heart diseases. Ultrasound imaging also identified craniofacial/head defects and body wall closure defects, which necropsy revealed as encephalocele, holoprosencephaly, omphalocele, or gastroschisis. Genome scanning mapped one ENU-induced mutation associated with persistence truncus arteriosus and holoprosencephaly to mouse chromosome 2, while another mutation associated with cardiac defects and omphalocele was mapped to mouse chromosome 17. These studies show the efficacy of this novel ultrasound scanning strategy for noninvasive ultrasound phenotyping to facilitate the recovery of ENU-induced mutations causing congenital heart defects and other extracardiac anomalies. JF - Physiological genomics AU - Shen, Yuan AU - Leatherbury, L AU - Rosenthal, J AU - Yu, Qing AU - Pappas, M A AU - Wessels, A AU - Lucas, J AU - Siegfried, B AU - Chatterjee, B AU - Svenson, Karen AU - Lo, C W AD - Laboratory of Developmental Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-8019, USA. Y1 - 2005/12/14/ PY - 2005 DA - 2005 Dec 14 SP - 23 EP - 36 VL - 24 IS - 1 KW - Ethylnitrosourea KW - P8M1T4190R KW - Index Medicus KW - Animals KW - Mice KW - Female KW - Pregnancy KW - Fetus -- radiation effects KW - Cardiovascular Physiological Phenomena KW - Ultrasonography, Prenatal KW - Heart Defects, Congenital -- diagnostic imaging KW - Ethylnitrosourea -- toxicity KW - Abnormalities, Multiple -- embryology KW - Heart Defects, Congenital -- embryology KW - Abnormalities, Multiple -- diagnostic imaging KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68896708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physiological+genomics&rft.atitle=Cardiovascular+phenotyping+of+fetal+mice+by+noninvasive+high-frequency+ultrasound+facilitates+recovery+of+ENU-induced+mutations+causing+congenital+cardiac+and+extracardiac+defects.&rft.au=Shen%2C+Yuan%3BLeatherbury%2C+L%3BRosenthal%2C+J%3BYu%2C+Qing%3BPappas%2C+M+A%3BWessels%2C+A%3BLucas%2C+J%3BSiegfried%2C+B%3BChatterjee%2C+B%3BSvenson%2C+Karen%3BLo%2C+C+W&rft.aulast=Shen&rft.aufirst=Yuan&rft.date=2005-12-14&rft.volume=24&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Physiological+genomics&rft.issn=1531-2267&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-02 N1 - Date created - 2005-12-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Role of Telomeres in Cancer and Aging: A Matter of Bad Ends T2 - 2005 Conference on Genes and Cancer AN - 39782539; 4055496 JF - 2005 Conference on Genes and Cancer AU - Blasco, Maria Y1 - 2005/12/12/ PY - 2005 DA - 2005 Dec 12 KW - Aging KW - Cancer KW - Telomeres KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39782539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Conference+on+Genes+and+Cancer&rft.atitle=Role+of+Telomeres+in+Cancer+and+Aging%3A+A+Matter+of+Bad+Ends&rft.au=Blasco%2C+Maria&rft.aulast=Blasco&rft.aufirst=Maria&rft.date=2005-12-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Conference+on+Genes+and+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://science.cancerresearchuk.org/genes_and_cancer/2005/programme?version =3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The TGF-b System in Breast Cancer: A Double-Edged Sword T2 - 2005 Conference on Genes and Cancer AN - 39730389; 4055489 JF - 2005 Conference on Genes and Cancer AU - Wakefield, Lalage Y1 - 2005/12/12/ PY - 2005 DA - 2005 Dec 12 KW - Breast cancer KW - Transforming growth factor-^b KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39730389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Conference+on+Genes+and+Cancer&rft.atitle=The+TGF-b+System+in+Breast+Cancer%3A+A+Double-Edged+Sword&rft.au=Wakefield%2C+Lalage&rft.aulast=Wakefield&rft.aufirst=Lalage&rft.date=2005-12-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Conference+on+Genes+and+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://science.cancerresearchuk.org/genes_and_cancer/2005/programme?version =3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Development of cancer chemopreventive drugs based on mechanistic approaches. AN - 68827011; 16083917 AB - One of the most important medical practices of the 21st century is the chemoprevention of cancer. Much progress has been made in this new emerging field, but much work remains before widespread use and practice of cancer prevention becomes commonplace. Cancer chemoprevention includes the concepts of inhibition, reversal, and retardation of the cancer process. The process of carcinogenesis requires 20-40 years to reach invasive cancer. This process follows multiple, diverse, and complex pathways in a stochastic process, called clonal evolution. Many of these pathways appear amenable to inhibition, reversal, or retardation at various points. It is urgent that we identify key pathways in the evolution of the cancer cell, which can be exploited to prevent this carcinogenesis process. Basic researchers are identifying many genetic lesions and epigenetic processes associated with the progression of precancer to invasive disease. These precancer lesions are also called intraepithelial neoplasia (IEN). Many of these early precancerous lesions favor cell division over quiescence and protect cells against apoptosis when signals are present. Many oncogenes, which are active during early development, are reactivated in adulthood by aberrant gene promoting errors. Normal regulatory genes can become mutated, making them insensitive to normal regulatory signals. Tumor suppressor genes are deleted or mutated rendering them inactive. These are several of a wide range of defects in cellular machinery, which can lead to evolution of the cancer phenotype. Errors may not have to appear in a defined order for cells to progress along the cancer pathway. To conquer this diverse disease, it is necessary to attack multiple key pathways at once for a predetermined period of time. Agent combination prevention strategies are, therefore, essential to decrease cancer morbidity. Each cancer type, organ location, or individual genetic background may require a custom combination of prevention strategies to be successful. JF - Mutation research AU - Steele, Vernon E AU - Kelloff, Gary J AD - National Cancer Institute, EPN 2108, MSC 7322, 9000 Rockville Pike, National Institutes of Health, Bethesda, MD 20892-7322, USA. vs1y@nih.gov Y1 - 2005/12/11/ PY - 2005 DA - 2005 Dec 11 SP - 16 EP - 23 VL - 591 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Anticarcinogenic Agents KW - 0 KW - Index Medicus KW - Humans KW - Anticarcinogenic Agents -- therapeutic use KW - Neoplasms -- prevention & control KW - Mutation KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68827011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Development+of+cancer+chemopreventive+drugs+based+on+mechanistic+approaches.&rft.au=Steele%2C+Vernon+E%3BKelloff%2C+Gary+J&rft.aulast=Steele&rft.aufirst=Vernon&rft.date=2005-12-11&rft.volume=591&rft.issue=1-2&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-15 N1 - Date created - 2005-11-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Translating Evidence-Based Practices into Health Policy: A Tool to Reduce Cancer Health Disparities T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39933087; 4084997 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Cooper, Leslie C AU - McCrae, Tarsha AU - Wingrove, Barbara K Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Cancer KW - Policies KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39933087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Translating+Evidence-Based+Practices+into+Health+Policy%3A+A+Tool+to+Reduce+Cancer+Health+Disparities&rft.au=Cooper%2C+Leslie+C%3BMcCrae%2C+Tarsha%3BWingrove%2C+Barbara+K&rft.aulast=Cooper&rft.aufirst=Leslie&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tobacco Dependence and Psychiatric Comorbidity: Possible Mechanisms of Association T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39922692; 4085209 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Riley, William Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Tobacco KW - Morbidity KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39922692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Tobacco+Dependence+and+Psychiatric+Comorbidity%3A+Possible+Mechanisms+of+Association&rft.au=Riley%2C+William&rft.aulast=Riley&rft.aufirst=William&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Education Level and Drinking Behavior Among Racial/Ethnic Groups: Results from the 20012002 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39920939; 4085275 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Yoon, Young-Hee AU - Yi, Hsiao-ye AU - Chen, Chiung M AU - Breslow, Rosalind Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Alcohols KW - Ethnic groups KW - Education KW - Drinking behavior KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39920939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Education+Level+and+Drinking+Behavior+Among+Racial%2FEthnic+Groups%3A+Results+from+the+20012002+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions+%28NESARC%29&rft.au=Yoon%2C+Young-Hee%3BYi%2C+Hsiao-ye%3BChen%2C+Chiung+M%3BBreslow%2C+Rosalind&rft.aulast=Yoon&rft.aufirst=Young-Hee&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - More Research will not Solve Health Disparities; Using Health Policy to Sustain Evidence-Based Practices T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39867618; 4084998 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Wingrove, Barbara K Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Policies KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39867618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=More+Research+will+not+Solve+Health+Disparities%3B+Using+Health+Policy+to+Sustain+Evidence-Based+Practices&rft.au=Wingrove%2C+Barbara+K&rft.aulast=Wingrove&rft.aufirst=Barbara&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fruit and Vegetable Consumption Among African American Adult Males: Correlates of Awareness and Consumption T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39852048; 4086733 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Robinson, JaMuir M AU - Massett, Holly AU - DiSogra, Lorelei AU - Moser, Richard P AU - Maibach, Edward AU - Weber, Deanne Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Africa KW - Ethnic groups KW - Vegetables KW - Fruits KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39852048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Fruit+and+Vegetable+Consumption+Among+African+American+Adult+Males%3A+Correlates+of+Awareness+and+Consumption&rft.au=Robinson%2C+JaMuir+M%3BMassett%2C+Holly%3BDiSogra%2C+Lorelei%3BMoser%2C+Richard+P%3BMaibach%2C+Edward%3BWeber%2C+Deanne&rft.aulast=Robinson&rft.aufirst=JaMuir&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Promoting the Body and Soul Program: Lessons Learned from the Nationwide Dissemination of a Health Promotion Program for African American Churches T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39851922; 4088585 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Williams, Alexis M AU - DiSogra, Lorelei Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Africa KW - Health promotion KW - Ethnic groups KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39851922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Injury+Prevention&rft.atitle=Factors+associated+with+bicycle+helmet+use+among+young+adolescents+in+a+multinational+sample&rft.au=Klein%2C+K+S%3BThompson%2C+D%3BScheidt%2C+P+C%3BOverpeck%2C+M+D%3BGross%2C+L+A&rft.aulast=Klein&rft.aufirst=K&rft.date=2005-10-01&rft.volume=11&rft.issue=5&rft.spage=288&rft.isbn=&rft.btitle=&rft.title=Injury+Prevention&rft.issn=13538047&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Associations Between Craving for Tobacco Cigarettes and Illicit Drugs T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39850588; 4085208 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Heishman, Stephen J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Tobacco KW - Drug addiction KW - Cigarettes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39850588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Associations+Between+Craving+for+Tobacco+Cigarettes+and+Illicit+Drugs&rft.au=Heishman%2C+Stephen+J&rft.aulast=Heishman&rft.aufirst=Stephen&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Community Environmnetal forum Theater: Tox and Risk Take the Stage T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39849469; 4086242 DE: JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Sullivan, john Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39849469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Community+Environmnetal+forum+Theater%3A+Tox+and+Risk+Take+the+Stage&rft.au=Sullivan%2C+john&rft.aulast=Sullivan&rft.aufirst=john&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of the Checkpoints Program on Parent-Imposed Driving Limits and Crash Outcomes Among Novice Teen Drivers at 6-Months Post-Licensure T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39842823; 4087776 DE: JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Simons-Morton, Bruce G Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39842823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Effects+of+the+Checkpoints+Program+on+Parent-Imposed+Driving+Limits+and+Crash+Outcomes+Among+Novice+Teen+Drivers+at+6-Months+Post-Licensure&rft.au=Simons-Morton%2C+Bruce+G&rft.aulast=Simons-Morton&rft.aufirst=Bruce&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of the Adaptations Index for Women with Pelvic Floor Disorders: The Value of the Patients Voice T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39842613; 4088642 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Wren, Patricia A Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Adaptations KW - Pelvis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39842613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Development+of+the+Adaptations+Index+for+Women+with+Pelvic+Floor+Disorders%3A+The+Value+of+the+Patients+Voice&rft.au=Wren%2C+Patricia+A&rft.aulast=Wren&rft.aufirst=Patricia&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Public Health in Public Housing: Improving Health, Changing Lives Results of a Strategic Planning Workshop to Address CVD and Asthma in Public Housing Settings T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39841833; 4088475 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Simon, Lenee N AU - Fulwood, Robinson AU - Morosco, Gregory J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Housing KW - Respiratory diseases KW - Asthma KW - Public health KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39841833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Public+Health+in+Public+Housing%3A+Improving+Health%2C+Changing+Lives+Results+of+a+Strategic+Planning+Workshop+to+Address+CVD+and+Asthma+in+Public+Housing+Settings&rft.au=Simon%2C+Lenee+N%3BFulwood%2C+Robinson%3BMorosco%2C+Gregory+J&rft.aulast=Simon&rft.aufirst=Lenee&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evidence Base for Cancer Screening Promotion: How Good a Fit for Public Health Practice? T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39833430; 4086007 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Breen, Nancy AU - Meissner, Helen Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Public health KW - Cancer KW - Screening KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39833430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Evidence+Base+for+Cancer+Screening+Promotion%3A+How+Good+a+Fit+for+Public+Health+Practice%3F&rft.au=Breen%2C+Nancy%3BMeissner%2C+Helen&rft.aulast=Breen&rft.aufirst=Nancy&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Dynamic Panel Study of the Linkages Between Smoking Behavior and Health Expenditures T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39828536; 4085326 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Shaw, James W AU - Horrace, William C Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Smoking KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39828536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=A+Dynamic+Panel+Study+of+the+Linkages+Between+Smoking+Behavior+and+Health+Expenditures&rft.au=Shaw%2C+James+W%3BHorrace%2C+William+C&rft.aulast=Shaw&rft.aufirst=James&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Drinking Patterns of Recovering Alcoholics: Results from the 20012002 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39828092; 4085235 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Chen, Chiung M AU - Yi, Hsiao-ye AU - Hilton, Michael E Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Alcohols KW - Ethanol KW - Alcoholics KW - Drinking KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39828092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Drinking+Patterns+of+Recovering+Alcoholics%3A+Results+from+the+20012002+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions+%28NESARC%29&rft.au=Chen%2C+Chiung+M%3BYi%2C+Hsiao-ye%3BHilton%2C+Michael+E&rft.aulast=Chen&rft.aufirst=Chiung&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Software for Survival Analysis of Studies Nested within Cohorts to Estimate Relative, Absolute, and Attributable Risks T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39827192; 4086582 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Katki, Hormuzd AU - Mark, Steven D Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Computer programs KW - Software KW - Survival KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39827192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Software+for+Survival+Analysis+of+Studies+Nested+within+Cohorts+to+Estimate+Relative%2C+Absolute%2C+and+Attributable+Risks&rft.au=Katki%2C+Hormuzd%3BMark%2C+Steven+D&rft.aulast=Katki&rft.aufirst=Hormuzd&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vesicular Trafficking And Signal Relay During Chemotaxis T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39824367; 4033803 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Kriebel, P W AU - Barr, V A AU - Mihaylov, V A AU - Parent, C A Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Chemotaxis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39824367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Vesicular+Trafficking+And+Signal+Relay+During+Chemotaxis&rft.au=Kriebel%2C+P+W%3BBarr%2C+V+A%3BMihaylov%2C+V+A%3BParent%2C+C+A&rft.aulast=Kriebel&rft.aufirst=P&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Look at Patterns of Tobacco and Alcohol Comorbidities in the U.S. Population T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39821741; 4085206 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Chiapella, Page AU - Fertig, Joanne Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - USA KW - Alcohols KW - Tobacco KW - Morbidity KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39821741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Glia&rft.atitle=Interactive+role+of+the+toll-like+receptor+4+and+reactive+oxygen+species+in+LPS-induced+microglia+activation.&rft.au=Qin%2C+Liya%3BLi%2C+Guorong%3BQian%2C+Xun%3BLiu%2C+Yuxin%3BWu%2C+Xuefei%3BLiu%2C+Bin%3BHong%2C+Jau-Shyong%3BBlock%2C+Michelle+L&rft.aulast=Qin&rft.aufirst=Liya&rft.date=2005-10-01&rft.volume=52&rft.issue=1&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=Glia&rft.issn=08941491&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Poverty, Perceived Discrimination, and Parenting Stress in African American mothers of Young Children T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39821163; 4088302 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Siefert, Kristine AU - Finlayson, Tracy L AU - Ismail, Amid AU - Delva, Jorge AU - Williams, David R AU - Amaya, Ashley AU - Lepkowski, James Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Africa KW - Children KW - Stress KW - Discrimination KW - Ethnic groups KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39821163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Poverty%2C+Perceived+Discrimination%2C+and+Parenting+Stress+in+African+American+mothers+of+Young+Children&rft.au=Siefert%2C+Kristine%3BFinlayson%2C+Tracy+L%3BIsmail%2C+Amid%3BDelva%2C+Jorge%3BWilliams%2C+David+R%3BAmaya%2C+Ashley%3BLepkowski%2C+James&rft.aulast=Siefert&rft.aufirst=Kristine&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cigarette Smoking Among Low-Income African American Women: A Hidden, Neglected, and Growing Public Health Problem T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39820661; 4085417 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Delva, Jorge AU - Tellez, Marisol AU - Finlayson, Tracy L AU - Gretebeck, Kimberlee AU - Siefert, Kristine AU - Williams, David R AU - Ismail, Amid Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Africa KW - Public health KW - Socio-economic aspects KW - Ethnic groups KW - Cigarette smoking KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39820661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Cigarette+Smoking+Among+Low-Income+African+American+Women%3A+A+Hidden%2C+Neglected%2C+and+Growing+Public+Health+Problem&rft.au=Delva%2C+Jorge%3BTellez%2C+Marisol%3BFinlayson%2C+Tracy+L%3BGretebeck%2C+Kimberlee%3BSiefert%2C+Kristine%3BWilliams%2C+David+R%3BIsmail%2C+Amid&rft.aulast=Delva&rft.aufirst=Jorge&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NIDCR: Addressing Oral Health Disparities through Research T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39820229; 4086116 DE: JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Nowjack-Raymer, Ruth Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39820229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=NIDCR%3A+Addressing+Oral+Health+Disparities+through+Research&rft.au=Nowjack-Raymer%2C+Ruth&rft.aulast=Nowjack-Raymer&rft.aufirst=Ruth&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuroglia Specific Expression of a FRET-based Calcium Indicator in Transgenic Mice T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39819514; 4033516 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Atkin, S D AU - Holtzclaw, L A AU - Pickel, J M AU - Russell, J T Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Mice KW - Calcium KW - Transgenic mice KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39819514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Neuroglia+Specific+Expression+of+a+FRET-based+Calcium+Indicator+in+Transgenic+Mice&rft.au=Atkin%2C+S+D%3BHoltzclaw%2C+L+A%3BPickel%2C+J+M%3BRussell%2C+J+T&rft.aulast=Atkin&rft.aufirst=S&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Changes in Chromatin Structure and Mobility in Living Cells at Sites of DNA Double-strand Breaks T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39818552; 4033320 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Kruhlak, M J AU - Celeste, A AU - Fernandez-Capetillo, O AU - Dellaire, AU - Muller, G W AU - McNally, J G AU - Bazett-Jones, D P AU - Nussenzweig, A Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Mobility KW - Chromatin KW - DNA damage KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39818552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Changes+in+Chromatin+Structure+and+Mobility+in+Living+Cells+at+Sites+of+DNA+Double-strand+Breaks&rft.au=Kruhlak%2C+M+J%3BCeleste%2C+A%3BFernandez-Capetillo%2C+O%3BDellaire%2C%3BMuller%2C+G+W%3BMcNally%2C+J+G%3BBazett-Jones%2C+D+P%3BNussenzweig%2C+A&rft.aulast=Kruhlak&rft.aufirst=M&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Unexpected Role of Bcl-2 Family Members in Mitochondrial Morphogenesis T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39818238; 4032445 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Youle, R J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Morphogenesis KW - Bcl-2 protein KW - Mitochondria KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39818238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=An+Unexpected+Role+of+Bcl-2+Family+Members+in+Mitochondrial+Morphogenesis&rft.au=Youle%2C+R+J&rft.aulast=Youle&rft.aufirst=R&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Diet, Activity, and Smoking: What do Data from Various Studies Reveal Regarding Their Relation? T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39817239; 4085207 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Augustson, Erik M AU - Wanke, Kay L AU - Bergen, Andrew W AU - Lanza, Elaine AU - Caporaso, Neil E Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Smoking KW - Diets KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39817239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Diet%2C+Activity%2C+and+Smoking%3A+What+do+Data+from+Various+Studies+Reveal+Regarding+Their+Relation%3F&rft.au=Augustson%2C+Erik+M%3BWanke%2C+Kay+L%3BBergen%2C+Andrew+W%3BLanza%2C+Elaine%3BCaporaso%2C+Neil+E&rft.aulast=Augustson&rft.aufirst=Erik&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hemoglobin Genotype-dependent Erythrocyte Membrane Potential Correlates to Innate Protection Against Severe Malaria T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39816027; 4033579 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Tokumasu, F AU - Dvorak, J A Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Malaria KW - Membrane potential KW - Hemoglobin KW - Erythrocytes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39816027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Hemoglobin+Genotype-dependent+Erythrocyte+Membrane+Potential+Correlates+to+Innate+Protection+Against+Severe+Malaria&rft.au=Tokumasu%2C+F%3BDvorak%2C+J+A&rft.aulast=Tokumasu&rft.aufirst=F&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modeling the Relationship Between Healthy People 2010 Upstream (Risk Factors and Screening) and Downstream (Mortality) Goals for Cancer T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39815446; 4086564 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Feuer, Eric J AU - Cronin, Kathleen Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Mortality KW - Cancer KW - Risk factors KW - Screening KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39815446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Modeling+the+Relationship+Between+Healthy+People+2010+Upstream+%28Risk+Factors+and+Screening%29+and+Downstream+%28Mortality%29+Goals+for+Cancer&rft.au=Feuer%2C+Eric+J%3BCronin%2C+Kathleen&rft.aulast=Feuer&rft.aufirst=Eric&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lessons Learned: Environmental Health Information Outreach to Native Americans T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39813844; 4086281 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Love, Cynthia AU - Dutcher, Gale AU - Arnesen, Stacey J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Ethnic groups KW - Environmental health KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39813844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Lessons+Learned%3A+Environmental+Health+Information+Outreach+to+Native+Americans&rft.au=Love%2C+Cynthia%3BDutcher%2C+Gale%3BArnesen%2C+Stacey+J&rft.aulast=Love&rft.aufirst=Cynthia&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Plasma Membrane ABCG1 Mediates Cellular Cholesterol Efflux to Lipoproteins T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39812018; 4034682 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Neufeld, E B AU - O'Brien, K AU - Demosky, S J AU - Stonik, J A AU - Sabol, S L AU - Malide, D AU - Combs, C A AU - Remaley, A T AU - Santamaina-Fojo, S AU - Brewer, H B Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Cholesterol KW - Plasma membranes KW - Lipoproteins KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39812018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Plasma+Membrane+ABCG1+Mediates+Cellular+Cholesterol+Efflux+to+Lipoproteins&rft.au=Neufeld%2C+E+B%3BO%27Brien%2C+K%3BDemosky%2C+S+J%3BStonik%2C+J+A%3BSabol%2C+S+L%3BMalide%2C+D%3BCombs%2C+C+A%3BRemaley%2C+A+T%3BSantamaina-Fojo%2C+S%3BBrewer%2C+H+B&rft.aulast=Neufeld&rft.aufirst=E&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of DetaD Endocytosis and Recycling T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39811741; 4034633 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Palardy, G AU - Goswami, M AU - Chitnis, A Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Protein turnover KW - Recycling KW - Endocytosis KW - Waste management KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39811741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Characterization+of+DetaD+Endocytosis+and+Recycling&rft.au=Palardy%2C+G%3BGoswami%2C+M%3BChitnis%2C+A&rft.aulast=Palardy&rft.aufirst=G&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - What Do Alcohol, Tobacco, Other Drugs, Physical Inactivity, and Mental Health Disorders Have in Common? T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39806038; 4085205 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Backinger, Cathy L AU - Chiapella, Page AU - Augustson, Erik M AU - Heishman, Stephen J AU - Riley, William Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Physical activity KW - Alcohols KW - Tobacco KW - Drugs KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39806038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=What+Do+Alcohol%2C+Tobacco%2C+Other+Drugs%2C+Physical+Inactivity%2C+and+Mental+Health+Disorders+Have+in+Common%3F&rft.au=Backinger%2C+Cathy+L%3BChiapella%2C+Page%3BAugustson%2C+Erik+M%3BHeishman%2C+Stephen+J%3BRiley%2C+William&rft.aulast=Backinger&rft.aufirst=Cathy&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Level and Concentration of Alcohol Consumption by Beverage Type and Demographic Characteristics: Results from the 20012002 NESARC T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39774878; 4085239 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Yi, Hsiao-ye AU - Chen, Chiung M AU - Hilton, Michael E Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Alcohols KW - Ethanol KW - Demography KW - Beverages KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39774878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Level+and+Concentration+of+Alcohol+Consumption+by+Beverage+Type+and+Demographic+Characteristics%3A+Results+from+the+20012002+NESARC&rft.au=Yi%2C+Hsiao-ye%3BChen%2C+Chiung+M%3BHilton%2C+Michael+E&rft.aulast=Yi&rft.aufirst=Hsiao-ye&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=0301472X&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Taking a Systems Approach to Tobacco Research: Modeling Dynamic Processes for a Complex World T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39773539; 4085324 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Leischow, Scott J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Tobacco KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39773539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Taking+a+Systems+Approach+to+Tobacco+Research%3A+Modeling+Dynamic+Processes+for+a+Complex+World&rft.au=Leischow%2C+Scott+J&rft.aulast=Leischow&rft.aufirst=Scott&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multi-Morbid DSM-IV Axis I Psychological and Axis II Personality Disorders and Their Association with Substance Use Disorders and Hazardous Drinking: Results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39768732; 4085237 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Falk, Daniel E AU - Yi, Hsiao-ye AU - Breslow, Rosalind Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Psychology KW - Alcohols KW - Personality KW - Drinking KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39768732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Multi-Morbid+DSM-IV+Axis+I+Psychological+and+Axis+II+Personality+Disorders+and+Their+Association+with+Substance+Use+Disorders+and+Hazardous+Drinking%3A+Results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions+%28NESARC%29&rft.au=Falk%2C+Daniel+E%3BYi%2C+Hsiao-ye%3BBreslow%2C+Rosalind&rft.aulast=Falk&rft.aufirst=Daniel&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Question of Whether DSM-IV Alcohol Dependence is a Categorical or a Continuous Variable T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39768696; 4085236 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Yahr, Harold T Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Alcohols KW - Drug dependence KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39768696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Question+of+Whether+DSM-IV+Alcohol+Dependence+is+a+Categorical+or+a+Continuous+Variable&rft.au=Yahr%2C+Harold+T&rft.aulast=Yahr&rft.aufirst=Harold&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interactions between HIV-1 and HIV-2 Gag Polyproteins in vivo T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39765071; 4035164 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Boyko, V P Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Polyproteins KW - Human immunodeficiency virus 2 KW - Human immunodeficiency virus 1 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39765071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Interactions+between+HIV-1+and+HIV-2+Gag+Polyproteins+in+vivo&rft.au=Boyko%2C+V+P&rft.aulast=Boyko&rft.aufirst=V&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Findings from the National Cancer Institute and Vietnamese American Medical Association Pap Test Barriers Survey for Health Care Providers T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39765038; 4087930 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Solomon, Felicia M AU - DeJoice, Rhonda W AU - Nguyen, Si V AU - Kwon, Harry T AU - Berlin, Nina Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Health care KW - Cancer KW - Barriers KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39765038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Findings+from+the+National+Cancer+Institute+and+Vietnamese+American+Medical+Association+Pap+Test+Barriers+Survey+for+Health+Care+Providers&rft.au=Solomon%2C+Felicia+M%3BDeJoice%2C+Rhonda+W%3BNguyen%2C+Si+V%3BKwon%2C+Harry+T%3BBerlin%2C+Nina&rft.aulast=Solomon&rft.aufirst=Felicia&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Disparities in the Consequences of Drug Use Among Minority Populations: Need for Culture-Specific Interventions T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39764894; 4085611 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Jones, Dionne AU - Fernandez, M Isabel AU - Harrison, Murelle G AU - McCoy, Clyde B AU - Devieux, Jessy G Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Drug abuse KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39764894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Disparities+in+the+Consequences+of+Drug+Use+Among+Minority+Populations%3A+Need+for+Culture-Specific+Interventions&rft.au=Jones%2C+Dionne%3BFernandez%2C+M+Isabel%3BHarrison%2C+Murelle+G%3BMcCoy%2C+Clyde+B%3BDevieux%2C+Jessy+G&rft.aulast=Jones&rft.aufirst=Dionne&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural Mechanism for Sterol Sensing and Transport by OSBP-related Proteins T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39764795; 4033929 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Im, Y. AU - Raychaudhuri, S AU - Prinz, W A AU - Hurley, J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Sterols KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39764795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Structural+Mechanism+for+Sterol+Sensing+and+Transport+by+OSBP-related+Proteins&rft.au=Im%2C+Y.%3BRaychaudhuri%2C+S%3BPrinz%2C+W+A%3BHurley%2C+J&rft.aulast=Im&rft.aufirst=Y.&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oral Cancer Knowledge, Attitudes, and Behaviors of At-Risk African American Men in Washington, D.C T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39760676; 4088377 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Boehm, Karina AU - Daum, Mary AU - Bobbin, Marilyn Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - USA, Washington KW - Africa KW - Ethnic groups KW - Cancer KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39760676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Oral+Cancer+Knowledge%2C+Attitudes%2C+and+Behaviors+of+At-Risk+African+American+Men+in+Washington%2C+D.C&rft.au=Boehm%2C+Karina%3BDaum%2C+Mary%3BBobbin%2C+Marilyn&rft.aulast=Boehm&rft.aufirst=Karina&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - National Cancer Institute's Cancer Information Service Research Program: Integrating Health Communication Research into Service T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39759349; 4088442 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Vanderpool, Robin Cline AU - Squiers, Linda Brafford Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Cancer KW - Communication KW - Research programs KW - Information services KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39759349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=National+Cancer+Institute%27s+Cancer+Information+Service+Research+Program%3A+Integrating+Health+Communication+Research+into+Service&rft.au=Vanderpool%2C+Robin+Cline%3BSquiers%2C+Linda+Brafford&rft.aulast=Vanderpool&rft.aufirst=Robin&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Thread-to-Grain Transition of Mitochondria Induced by Cytomegalovirus-Encoded vMIA is Independent of Pro-Apoptotic Bcl-2 Family Member, Bax T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39756524; 4033519 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Norris, K L AU - Karbowski, M AU - Dlouhy, B AU - Youle, R J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Bax protein KW - Bcl-2 protein KW - Mitochondria KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39756524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Thread-to-Grain+Transition+of+Mitochondria+Induced+by+Cytomegalovirus-Encoded+vMIA+is+Independent+of+Pro-Apoptotic+Bcl-2+Family+Member%2C+Bax&rft.au=Norris%2C+K+L%3BKarbowski%2C+M%3BDlouhy%2C+B%3BYoule%2C+R+J&rft.aulast=Norris&rft.aufirst=K&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chromogranin A Deficiency in Transgenic Mice Leads to Aberrant Chromaffin Granule Biogenesis T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39755746; 4033498 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Kim, T AU - Zhang, C AU - Sun, Z AU - Wu, H. AU - Loh, Y P Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Chromaffin granules KW - Biogenesis KW - Mice KW - Chromogranins KW - Evolution KW - Transgenic mice KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39755746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Chromogranin+A+Deficiency+in+Transgenic+Mice+Leads+to+Aberrant+Chromaffin+Granule+Biogenesis&rft.au=Kim%2C+T%3BZhang%2C+C%3BSun%2C+Z%3BWu%2C+H.%3BLoh%2C+Y+P&rft.aulast=Kim&rft.aufirst=T&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MAD1 Haplo-insufficiency and Tumor Development in Mice T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39755181; 4033379 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Iwanaga, Y AU - Miyazato, A AU - Chi, Y AU - Haller, K AU - Ward, J M AU - Jeang, K Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Mice KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39755181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=MAD1+Haplo-insufficiency+and+Tumor+Development+in+Mice&rft.au=Iwanaga%2C+Y%3BMiyazato%2C+A%3BChi%2C+Y%3BHaller%2C+K%3BWard%2C+J+M%3BJeang%2C+K&rft.aulast=Iwanaga&rft.aufirst=Y&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Patient Recruitment to a Phase III Complementary and Alternative Medicine Clinical Trial: Overcoming Challenges T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39753698; 4088092 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Cotler, Alyssa AU - Arciniega, Jacqueline AU - Doner, Lynne AU - Lange, Amy AU - Liu, Irene AU - Nahin, Richard AU - Tisch, Jennifer AU - Lamas, Gervasio AU - Lambe, Lindsay AU - Clapp-Channing, Nancy Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Clinical trials KW - Recruitment KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39753698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Patient+Recruitment+to+a+Phase+III+Complementary+and+Alternative+Medicine+Clinical+Trial%3A+Overcoming+Challenges&rft.au=Cotler%2C+Alyssa%3BArciniega%2C+Jacqueline%3BDoner%2C+Lynne%3BLange%2C+Amy%3BLiu%2C+Irene%3BNahin%2C+Richard%3BTisch%2C+Jennifer%3BLamas%2C+Gervasio%3BLambe%2C+Lindsay%3BClapp-Channing%2C+Nancy&rft.aulast=Cotler&rft.aufirst=Alyssa&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ezrin is Activated by PKC and Contributes to Metastatic Phenotype of Osteosarcoma Cells T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39752698; 4032573 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Ren, L AU - Hong, S AU - Cassavaugh, J AU - Khanna, C Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Ezrin KW - Osteosarcoma cells KW - Phenotypes KW - Metastases KW - Protein kinase C KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39752698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Ezrin+is+Activated+by+PKC+and+Contributes+to+Metastatic+Phenotype+of+Osteosarcoma+Cells&rft.au=Ren%2C+L%3BHong%2C+S%3BCassavaugh%2C+J%3BKhanna%2C+C&rft.aulast=Ren&rft.aufirst=L&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Perturbation of the Endocytic Pathway Affects Expression and Translocation of Salmonella-effector Proteins in Cultured Epithelial Cells T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39744792; 4033598 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Fuentes, P AU - Drecktrah, D AU - Knodler, L A AU - Steele-Mortimer, O Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Translocation KW - Fish culture KW - Epithelial cells KW - Salmonidae KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39744792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Perturbation+of+the+Endocytic+Pathway+Affects+Expression+and+Translocation+of+Salmonella-effector+Proteins+in+Cultured+Epithelial+Cells&rft.au=Fuentes%2C+P%3BDrecktrah%2C+D%3BKnodler%2C+L+A%3BSteele-Mortimer%2C+O&rft.aulast=Fuentes&rft.aufirst=P&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a Polarized Epithelial Cell Model to Study the Role of Akt/PKB in Salmonella Enterica Interactions with the Intestinal Epithelium T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39744709; 4033597 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Ireland, R AU - Steele-Mortimer, O Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Intestine KW - Cell culture KW - Epithelium KW - AKT protein KW - Epithelial cells KW - Salmonella enterica KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39744709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Development+of+a+Polarized+Epithelial+Cell+Model+to+Study+the+Role+of+Akt%2FPKB+in+Salmonella+Enterica+Interactions+with+the+Intestinal+Epithelium&rft.au=Ireland%2C+R%3BSteele-Mortimer%2C+O&rft.aulast=Ireland&rft.aufirst=R&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2005.03.009 L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - K-165: An Organelle Motor in the Squid Giant Axon T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39741974; 4034277 JF - 45th Annual Meeting of the American Society for Cell Biology AU - DeGiorgis, J A AU - Gallant, P E AU - Reese, T S AU - Galbraith, J A Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Organelles KW - Neurons KW - Giant axons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39741974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=K-165%3A+An+Organelle+Motor+in+the+Squid+Giant+Axon&rft.au=DeGiorgis%2C+J+A%3BGallant%2C+P+E%3BReese%2C+T+S%3BGalbraith%2C+J+A&rft.aulast=DeGiorgis&rft.aufirst=J&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fibroblast Growth Factor (FGF) Signaling Regulates the Expression and the Activity of Matrix Metalloproteases (MMPs) during Mouse Submandibular Gland (SMG) Branching Morphogenesis T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39738747; 4034884 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Rebustini, I T AU - Hoffman, M P Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Fibroblast growth factor KW - Morphogenesis KW - Glands KW - Signal transduction KW - Submandibular gland KW - Matrix metalloproteinase KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39738747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Fibroblast+Growth+Factor+%28FGF%29+Signaling+Regulates+the+Expression+and+the+Activity+of+Matrix+Metalloproteases+%28MMPs%29+during+Mouse+Submandibular+Gland+%28SMG%29+Branching+Morphogenesis&rft.au=Rebustini%2C+I+T%3BHoffman%2C+M+P&rft.aulast=Rebustini&rft.aufirst=I&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Curing of Yeast [PSI@@u+@] Prion by Guanidine Inactivation of Hsp104 Does Not Require Cell Division T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39736717; 4034737 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Wu, Y. AU - Greene, L E AU - Masison, D C AU - Eisenberg, E Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Curing KW - Cell division KW - Prion protein KW - Guanidine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39736717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Curing+of+Yeast+%5BPSI%40%40u%2B%40%5D+Prion+by+Guanidine+Inactivation+of+Hsp104+Does+Not+Require+Cell+Division&rft.au=Wu%2C+Y.%3BGreene%2C+L+E%3BMasison%2C+D+C%3BEisenberg%2C+E&rft.aulast=Wu&rft.aufirst=Y.&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Expression of Cdh23 Isoforms in the Cochlea and Retina of Wild Type and Waltzer Mice T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39735260; 4034899 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Lagziel, A AU - Ahmed, Z M AU - Peters, L M AU - Friedman, T B AU - Morell, R J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Mice KW - Cochlea KW - Retina KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39735260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Differential+Expression+of+Cdh23+Isoforms+in+the+Cochlea+and+Retina+of+Wild+Type+and+Waltzer+Mice&rft.au=Lagziel%2C+A%3BAhmed%2C+Z+M%3BPeters%2C+L+M%3BFriedman%2C+T+B%3BMorell%2C+R+J&rft.aulast=Lagziel&rft.aufirst=A&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Conditional Ablation of Nonmuscle Myosin II-B in the Mouse Heart T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39733297; 4032757 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Singh, A K AU - Wei, Q AU - Takeda, K AU - Zerfas, P AU - Birdsall, C AU - Sidenko, S AU - Adelstein, R S Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Myosin KW - Ablation KW - Heart KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39733297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Conditional+Ablation+of+Nonmuscle+Myosin+II-B+in+the+Mouse+Heart&rft.au=Singh%2C+A+K%3BWei%2C+Q%3BTakeda%2C+K%3BZerfas%2C+P%3BBirdsall%2C+C%3BSidenko%2C+S%3BAdelstein%2C+R+S&rft.aulast=Singh&rft.aufirst=A&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of GlUT1 in HTLV Infection T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39733146; 4033753 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Lisinski, I M AU - Takenouchi, N AU - Kazunori, F AU - Yao, K AU - Ruscetti, F W AU - Jones, K AU - Cushman, S W AU - Jacobsen, S Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Infection KW - Human T-lymphotropic virus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39733146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Role+of+GlUT1+in+HTLV+Infection&rft.au=Lisinski%2C+I+M%3BTakenouchi%2C+N%3BKazunori%2C+F%3BYao%2C+K%3BRuscetti%2C+F+W%3BJones%2C+K%3BCushman%2C+S+W%3BJacobsen%2C+S&rft.aulast=Lisinski&rft.aufirst=I&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Six1 Promotes Rhabdomyosarcoma Metastasis through Ezrin T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39732291; 4033855 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Yu, Y. Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Ezrin KW - Metastases KW - Rhabdomyosarcoma KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39732291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Six1+Promotes+Rhabdomyosarcoma+Metastasis+through+Ezrin&rft.au=Yu%2C+Y.&rft.aulast=Yu&rft.aufirst=Y.&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Examination of Endothelial Lumenization Processes in vivo Using Zebrafish Danio rerio T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39732155; 4033835 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Kamei, M AU - Bayless, K J AU - Davis, G E AU - Weinstein, B M Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Freshwater fish KW - Danio rerio KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39732155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Examination+of+Endothelial+Lumenization+Processes+in+vivo+Using+Zebrafish+Danio+rerio&rft.au=Kamei%2C+M%3BBayless%2C+K+J%3BDavis%2C+G+E%3BWeinstein%2C+B+M&rft.aulast=Kamei&rft.aufirst=M&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Targeted Disruption of N-RAP Gene Function by RNA Interference: A Role for N-RAP in Myofibril Organization T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39727805; 4034257 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Dhume, A AU - Horowits, R Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - RNA-mediated interference KW - Myofibrils KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39727805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Targeted+Disruption+of+N-RAP+Gene+Function+by+RNA+Interference%3A+A+Role+for+N-RAP+in+Myofibril+Organization&rft.au=Dhume%2C+A%3BHorowits%2C+R&rft.aulast=Dhume&rft.aufirst=A&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Centrosome and Golgi Complex Reorganization during Myogenesis Can Proceed without a Coherent, Dynamic Microtubule Network T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39727518; 4033718 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Zaal, K J M AU - Reid, E AU - Gundersen, G G AU - Zhang, T AU - Ralston, E Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Microtubules KW - Golgi apparatus KW - Myogenesis KW - Centrosomes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39727518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Centrosome+and+Golgi+Complex+Reorganization+during+Myogenesis+Can+Proceed+without+a+Coherent%2C+Dynamic+Microtubule+Network&rft.au=Zaal%2C+K+J+M%3BReid%2C+E%3BGundersen%2C+G+G%3BZhang%2C+T%3BRalston%2C+E&rft.aulast=Zaal&rft.aufirst=K+J&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transcription Factor Sp3 and DNA Methylation Regulate the Nonmuscle Myosin Heavy Chain II-C Promoter T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39726235; 4032759 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Chung, M AU - Adelstein, R S AU - Kawamoto, S Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - DNA methylation KW - Promoters KW - Myosin KW - Transcription factors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39726235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Transcription+Factor+Sp3+and+DNA+Methylation+Regulate+the+Nonmuscle+Myosin+Heavy+Chain+II-C+Promoter&rft.au=Chung%2C+M%3BAdelstein%2C+R+S%3BKawamoto%2C+S&rft.aulast=Chung&rft.aufirst=M&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reduction of ss-Integrin Expression and Cell Attachments in Nonmucle Myosin II-B Null Mouse Embryonic Fibroblasts T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39726194; 4032755 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Kim, K AU - Adelstein, R S Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Myosin KW - Embryo fibroblasts KW - Embryos KW - Fibroblasts KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39726194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Reduction+of+ss-Integrin+Expression+and+Cell+Attachments+in+Nonmucle+Myosin+II-B+Null+Mouse+Embryonic+Fibroblasts&rft.au=Kim%2C+K%3BAdelstein%2C+R+S&rft.aulast=Kim&rft.aufirst=K&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cellular Regulation of the Hematopoietic Stem Cell Niche T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39726156; 4033097 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Gillette, J M AU - Lippincott-Schwartz, J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Stem cells KW - Niches KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39726156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Cellular+Regulation+of+the+Hematopoietic+Stem+Cell+Niche&rft.au=Gillette%2C+J+M%3BLippincott-Schwartz%2C+J&rft.aulast=Gillette&rft.aufirst=J&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a Novel Monoclonal Antibody to a Cell Surface Antigen that Isolates Neuronal Stem Cells From Murine and Pig Adult Skeletal Muscle and Murine Embryo T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39724401; 4034658 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Winitsky, S O AU - Gopal, T V AU - Hassanzadeh, S AU - Kassahun, Y A AU - Epstein, N D Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Stem cells KW - Skeletal muscle KW - Embryos KW - Monoclonal antibodies KW - Antigens KW - Cell surface KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39724401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Identification+of+a+Novel+Monoclonal+Antibody+to+a+Cell+Surface+Antigen+that+Isolates+Neuronal+Stem+Cells+From+Murine+and+Pig+Adult+Skeletal+Muscle+and+Murine+Embryo&rft.au=Winitsky%2C+S+O%3BGopal%2C+T+V%3BHassanzadeh%2C+S%3BKassahun%2C+Y+A%3BEpstein%2C+N+D&rft.aulast=Winitsky&rft.aufirst=S&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Sub-cellular Localization of NGEP, a Prostate Specific Protein in Two Prostate Cancer Cell Lines. T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39724094; 4033191 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Das, S AU - Nagata, S AU - Bera, T AU - Pastan, I Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Tumor cell lines KW - Prostate cancer KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39724094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Differential+Sub-cellular+Localization+of+NGEP%2C+a+Prostate+Specific+Protein+in+Two+Prostate+Cancer+Cell+Lines.&rft.au=Das%2C+S%3BNagata%2C+S%3BBera%2C+T%3BPastan%2C+I&rft.aulast=Das&rft.aufirst=S&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Elucidating the Structural Role of Dnm1 in Mitochondrial Fission T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39723804; 4034508 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Mears, J A AU - Ingerman, E AU - Marino, M AU - Nunnari, J AU - Hinshaw, J E Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Mitochondria KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39723804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Elucidating+the+Structural+Role+of+Dnm1+in+Mitochondrial+Fission&rft.au=Mears%2C+J+A%3BIngerman%2C+E%3BMarino%2C+M%3BNunnari%2C+J%3BHinshaw%2C+J+E&rft.aulast=Mears&rft.aufirst=J&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Truncated Leishmania K39 Kinesin Protein Binds Along Cortical Microtubules in an ATP-Dependant Manner and Accumulates at the Tip of the Cell T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39722001; 4034276 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Gerald, N J AU - Dwyer, D M Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Microtubules KW - Kinesin KW - Leishmania KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39722001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=A+Truncated+Leishmania+K39+Kinesin+Protein+Binds+Along+Cortical+Microtubules+in+an+ATP-Dependant+Manner+and+Accumulates+at+the+Tip+of+the+Cell&rft.au=Gerald%2C+N+J%3BDwyer%2C+D+M&rft.aulast=Gerald&rft.aufirst=N&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Probing Arf Guanine Nucleotide Exchange Factor (GEF) Specificity with Chimeric Proteins T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39718071; 4033262 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Cohen, L A AU - Donaldson, J G Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Nucleotides KW - Specificity KW - Guanine nucleotide exchange factor KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39718071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Probing+Arf+Guanine+Nucleotide+Exchange+Factor+%28GEF%29+Specificity+with+Chimeric+Proteins&rft.au=Cohen%2C+L+A%3BDonaldson%2C+J+G&rft.aulast=Cohen&rft.aufirst=L&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Calcium Signaling Protein Complexes in Oligodendrocyte Precursor (OP Cell) Membranes Isolated from Rat Cortices T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39715200; 4034154 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Weerth, S H AU - Hauser, J AU - Russell, J T Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Oligodendrocytes KW - Calcium signalling KW - Cell membranes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39715200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Calcium+Signaling+Protein+Complexes+in+Oligodendrocyte+Precursor+%28OP+Cell%29+Membranes+Isolated+from+Rat+Cortices&rft.au=Weerth%2C+S+H%3BHauser%2C+J%3BRussell%2C+J+T&rft.aulast=Weerth&rft.aufirst=S&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nitric Oxide Activates Peroxisome Proliferator-Activated Receptor Gamma through a p38 MAPK Signaling Pathway T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39712448; 4034577 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Ptasinska, A AU - Wang, S AU - Zhang, J AU - Danner, R L Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Peroxisome proliferator-activated receptors KW - MAP kinase KW - Signal transduction KW - Nitric oxide KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39712448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Nitric+Oxide+Activates+Peroxisome+Proliferator-Activated+Receptor+Gamma+through+a+p38+MAPK+Signaling+Pathway&rft.au=Ptasinska%2C+A%3BWang%2C+S%3BZhang%2C+J%3BDanner%2C+R+L&rft.aulast=Ptasinska&rft.aufirst=A&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rab11a is Required for Canalicular Biogenesis in WIF-B9 Hepatic Cells T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39712379; 4034557 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Wakabayashi, Y AU - Dutt, P AU - Lippincott-Schwartz, J AU - Arias, I M Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Biogenesis KW - Liver KW - Evolution KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39712379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Rab11a+is+Required+for+Canalicular+Biogenesis+in+WIF-B9+Hepatic+Cells&rft.au=Wakabayashi%2C+Y%3BDutt%2C+P%3BLippincott-Schwartz%2C+J%3BArias%2C+I+M&rft.aulast=Wakabayashi&rft.aufirst=Y&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Racial/Ethnic Variation in Colorectal Cancer Diagnosis: Should Screening Guidelines Consider Race/Ethnicity? T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39711388; 4085000 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Shavers, Vickie L Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Ethnic groups KW - Colorectal cancer KW - Races KW - Screening KW - Subpopulations KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39711388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Racial%2FEthnic+Variation+in+Colorectal+Cancer+Diagnosis%3A+Should+Screening+Guidelines+Consider+Race%2FEthnicity%3F&rft.au=Shavers%2C+Vickie+L&rft.aulast=Shavers&rft.aufirst=Vickie&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Metabolism of Tasidotin (ILX-651) by Cancer Cells: Mechanisms of Activation and Resistance T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39710995; 4033936 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Bai, R AU - Edler, M C AU - Copeland, T D AU - Schmid, S AU - Arthaud, L E AU - Hamel, E Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Metabolism KW - Cancer KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39710995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Chemistry&rft.atitle=High-Resolution+Serum+Proteomic+Profiling+of+Alzheimer+Disease+Samples+Reveals+Disease-Specific%2C+Carrier-Protein-Bound+Mass+Signatures&rft.au=Lopez%2C+Mary+F%3BMikulskis%2C+Alvydas%3BKuzdzal%2C+Scott%3BBennett%2C+David+A%3BKelly%2C+Jeremiah%3BGolenko%2C+Eva%3BDiCesare%2C+Joseph%3BDenoyer%2C+Eric%3BPatton%2C+Wayne+F%3BEdiger%2C+Richard%3BSapp%2C+Lisa%3BZiegert%2C+Tillmann%3BLynch%2C+Christopher%3BKramer%2C+Susan%3BWhiteley%2C+Gordon+R%3BWall%2C+Michael+R%3BMannion%2C+David+P%3Bdella+Cioppa%2C+Guy%3BRakitan%2C+John+S%3BWolfe%2C+Gershon+M&rft.aulast=Lopez&rft.aufirst=Mary&rft.date=2005-10-01&rft.volume=51&rft.issue=10&rft.spage=1946&rft.isbn=&rft.btitle=&rft.title=Clinical+Chemistry&rft.issn=00099147&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gonadotropin Receptor-Mediated Activation of G Protein-Activated Inwardly Rectifying K@@u+@ (GIRK) Channels in Hypothalamic GnRH Neurons. T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39710919; 4033515 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Hu, L. AU - Krsmanovic, L Z AU - Catt, K J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Potassium channels (inwardly-rectifying) KW - Pituitary (anterior) KW - Potassium KW - Channels KW - Neurons KW - Hypothalamus KW - Gonadotropin-releasing hormone KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39710919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Gonadotropin+Receptor-Mediated+Activation+of+G+Protein-Activated+Inwardly+Rectifying+K%40%40u%2B%40+%28GIRK%29+Channels+in+Hypothalamic+GnRH+Neurons.&rft.au=Hu%2C+L.%3BKrsmanovic%2C+L+Z%3BCatt%2C+K+J&rft.aulast=Hu&rft.aufirst=L.&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The szy-20 (bs52) Mutation is a Suppressor of zyg-1 and Defines a Novel Regulator of the Cell Cycle T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39710413; 4033389 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Song, M Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Mutation KW - Suppressors KW - Cell cycle KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39710413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+szy-20+%28bs52%29+Mutation+is+a+Suppressor+of+zyg-1+and+Defines+a+Novel+Regulator+of+the+Cell+Cycle&rft.au=Song%2C+M&rft.aulast=Song&rft.aufirst=M&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Cyclin Dependent Kinase 5 Activator p39 Binds Myosin Essential Light Chain T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39708509; 4032764 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Tripathi, B K AU - Ledee, D R AU - Zelenka, P S Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Myosin KW - Light chains KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39708509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Cyclin+Dependent+Kinase+5+Activator+p39+Binds+Myosin+Essential+Light+Chain&rft.au=Tripathi%2C+B+K%3BLedee%2C+D+R%3BZelenka%2C+P+S&rft.aulast=Tripathi&rft.aufirst=B&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Increased Expression of the Inserted Myosin II-C Isoform in Tumor Cell Lines T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39708424; 4032760 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Jana, S S AU - Adelstein, R S Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Myosin KW - Tumor cell lines KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39708424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Increased+Expression+of+the+Inserted+Myosin+II-C+Isoform+in+Tumor+Cell+Lines&rft.au=Jana%2C+S+S%3BAdelstein%2C+R+S&rft.aulast=Jana&rft.aufirst=S&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intracellular Dynamics of Drosophila Myosin-V T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39705120; 4032686 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Toth, J AU - Sellers, J R Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Drosophila KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39705120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Intracellular+Dynamics+of+Drosophila+Myosin-V&rft.au=Toth%2C+J%3BSellers%2C+J+R&rft.aulast=Toth&rft.aufirst=J&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tobacco and Alcohol Use Among Homosexual and Bisexual Adults in California T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39705017; 4085420 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Grauman, Alyssa R AU - Lawrence, Deirdre M AU - Allen, Nathaniel AU - Davis, William Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - USA, California KW - Alcohols KW - Homosexuality KW - Tobacco KW - Bisexual KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39705017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Tobacco+and+Alcohol+Use+Among+Homosexual+and+Bisexual+Adults+in+California&rft.au=Grauman%2C+Alyssa+R%3BLawrence%2C+Deirdre+M%3BAllen%2C+Nathaniel%3BDavis%2C+William&rft.aulast=Grauman&rft.aufirst=Alyssa&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Monitoring the ER Luminal and the Cytosolic Face of the ERAD Substrate CD3delta T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39695995; 4033288 DE: JF - 45th Annual Meeting of the American Society for Cell Biology AU - Lorenz, H AU - Lippincott-Schwartz, J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39695995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Monitoring+the+ER+Luminal+and+the+Cytosolic+Face+of+the+ERAD+Substrate+CD3delta&rft.au=Lorenz%2C+H%3BLippincott-Schwartz%2C+J&rft.aulast=Lorenz&rft.aufirst=H&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Avian Malaria Parasite Plasmodium gallinaceum Modifies the Surface Topography of Infected Erythrocytes T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39693376; 4033580 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Arie, T AU - Dorward, D W AU - Dvorak, J A Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Parasites KW - Malaria KW - Erythrocytes KW - Topography KW - Surface topography KW - Plasmodium gallinaceum KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39693376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Avian+Malaria+Parasite+Plasmodium+gallinaceum+Modifies+the+Surface+Topography+of+Infected+Erythrocytes&rft.au=Arie%2C+T%3BDorward%2C+D+W%3BDvorak%2C+J+A&rft.aulast=Arie&rft.aufirst=T&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Src-kinase Expression Inhibits Compensatory Endocytosis During Early Sea Urchin Development T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39689323; 4033263 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Covian-Nares, J F AU - Vogel, S S Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Endocytosis KW - Echinoidea KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39689323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Src-kinase+Expression+Inhibits+Compensatory+Endocytosis+During+Early+Sea+Urchin+Development&rft.au=Covian-Nares%2C+J+F%3BVogel%2C+S+S&rft.aulast=Covian-Nares&rft.aufirst=J&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Folding of Nascent SecM within the Ribosome Exit Tunnel is Required for Translation Arrest T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39688961; 4033166 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Woolhead, C A AU - Johnson, A E AU - Bernstein, H D Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Translation KW - Tunnels KW - Ribosomes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39688961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Folding+of+Nascent+SecM+within+the+Ribosome+Exit+Tunnel+is+Required+for+Translation+Arrest&rft.au=Woolhead%2C+C+A%3BJohnson%2C+A+E%3BBernstein%2C+H+D&rft.aulast=Woolhead&rft.aufirst=C&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Rap-GEF/Rap GTPase Signaling Controls Stem Cell Niche Formation through Regulating Adherens Junctions in the Drosophila Testis T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39687447; 4034851 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Hou, S X AU - Wang, H AU - Singh, S AU - Zheng, Z AU - Oh, S. AU - Chen, X Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Adherens junctions KW - Stem cells KW - Guanosinetriphosphatase KW - Signal transduction KW - Niches KW - Testes KW - Drosophila KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39687447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=A+Rap-GEF%2FRap+GTPase+Signaling+Controls+Stem+Cell+Niche+Formation+through+Regulating+Adherens+Junctions+in+the+Drosophila+Testis&rft.au=Hou%2C+S+X%3BWang%2C+H%3BSingh%2C+S%3BZheng%2C+Z%3BOh%2C+S.%3BChen%2C+X&rft.aulast=Hou&rft.aufirst=S&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phosphatases and Kinases Regulate AP2 Binding and Release from Plasma Membrane T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39683854; 4034995 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Yim, Y AU - Scarselletta, S AU - Eisenberg, E AU - Greene, L E Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Plasma membranes KW - Phosphatase KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39683854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Phosphatases+and+Kinases+Regulate+AP2+Binding+and+Release+from+Plasma+Membrane&rft.au=Yim%2C+Y%3BScarselletta%2C+S%3BEisenberg%2C+E%3BGreene%2C+L+E&rft.aulast=Yim&rft.aufirst=Y&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Syntabulin-Mediated Anterograde Transport of Mitochondria Along Neuronal Processes T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39682783; 4033541 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Cai, Q AU - Sheng, Z Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Anterograde transport KW - Mitochondria KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39682783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Caplan%2C+Bryan&rft.aulast=Caplan&rft.aufirst=Bryan&rft.date=2007-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0-691-12942-8&rft.btitle=The+myth+of+the+rational+voter%3A+Why+democracies+choose+bad+policies&rft.title=The+myth+of+the+rational+voter%3A+Why+democracies+choose+bad+policies&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Mammary Stem Cell Niche Modulates the Repertoire of Testicular Stem Cells T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39681415; 4034854 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Boulanger, C A AU - Mack, D L AU - Booth, B W AU - Smith, G H Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Stem cells KW - Niches KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39681415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Mammary+Stem+Cell+Niche+Modulates+the+Repertoire+of+Testicular+Stem+Cells&rft.au=Boulanger%2C+C+A%3BMack%2C+D+L%3BBooth%2C+B+W%3BSmith%2C+G+H&rft.aulast=Boulanger&rft.aufirst=C&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The SPG3A Hereditary Spastic Paraplegia Protein Atlastin-1 is Enriched in Axonal Growth Cones T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39680851; 4034742 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Zhu, P AU - Tao-Cheng, S J H AU - Smith, C L AU - Stadler, J AU - Yang, S M AU - Blackstone, C Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Growth cones KW - Spastic paraplegia KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39680851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+SPG3A+Hereditary+Spastic+Paraplegia+Protein+Atlastin-1+is+Enriched+in+Axonal+Growth+Cones&rft.au=Zhu%2C+P%3BTao-Cheng%2C+S+J+H%3BSmith%2C+C+L%3BStadler%2C+J%3BYang%2C+S+M%3BBlackstone%2C+C&rft.aulast=Zhu&rft.aufirst=P&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Displacement of the Bromodomain Protein Brd4 from Chromosomes is Required for the Recovery from Anti-Microtubule Drug Induced Mitotic Arrest T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39680360; 4035054 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Nishiyama, A AU - Ozato, K Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Drugs KW - Chromosomes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39680360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Displacement+of+the+Bromodomain+Protein+Brd4+from+Chromosomes+is+Required+for+the+Recovery+from+Anti-Microtubule+Drug+Induced+Mitotic+Arrest&rft.au=Nishiyama%2C+A%3BOzato%2C+K&rft.aulast=Nishiyama&rft.aufirst=A&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Drosophila Myosin V T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39679090; 4034615 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Hong, A AU - Toth, J AU - Sellers, J R Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Myosin KW - Drosophila KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39679090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Drosophila+Myosin+V&rft.au=Hong%2C+A%3BToth%2C+J%3BSellers%2C+J+R&rft.aulast=Hong&rft.aufirst=A&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Agrin-induced Formation of Filopodia Depends on GAG Chains and Cdc42 T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39678178; 4034396 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Lin, L AU - McCroskery, S AU - Ross, J M AU - Daniels, M P Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Pseudopodia KW - Cdc42 protein KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39678178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Agrin-induced+Formation+of+Filopodia+Depends+on+GAG+Chains+and+Cdc42&rft.au=Lin%2C+L%3BMcCroskery%2C+S%3BRoss%2C+J+M%3BDaniels%2C+M+P&rft.aulast=Lin&rft.aufirst=L&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Over Expression of Human ClpP Reduces AIF Levels and Inhibits Cisplatin-Induced Apoptosis in Huh4 Cells. T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39674273; 4032496 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Zhang, Y AU - Barr, V AU - Maurizi1, M. R. Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Apoptosis-inducing factor KW - Apoptosis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39674273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Over+Expression+of+Human+ClpP+Reduces+AIF+Levels+and+Inhibits+Cisplatin-Induced+Apoptosis+in+Huh4+Cells.&rft.au=Zhang%2C+Y%3BBarr%2C+V%3BMaurizi1%2C+M.+R.&rft.aulast=Zhang&rft.aufirst=Y&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activated AKT Regulates Nf-?B Activation, P53 Inhibition and Cell Survival in HTLV-1-transformed Cells T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39674142; 4032454 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Jeong, S AU - Pise-Masison, C A AU - Radonovich, M F AU - Park, H AU - Brady, J N Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - AKT protein KW - Cell survival KW - P53 protein KW - Human T-lymphotropic virus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39674142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Activated+AKT+Regulates+Nf-%3FB+Activation%2C+P53+Inhibition+and+Cell+Survival+in+HTLV-1-transformed+Cells&rft.au=Jeong%2C+S%3BPise-Masison%2C+C+A%3BRadonovich%2C+M+F%3BPark%2C+H%3BBrady%2C+J+N&rft.aulast=Jeong&rft.aufirst=S&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Actin Rockets Guide Membrane Protrusion and Position Primed Integrins to Direct Pathfinding T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39673028; 4032846 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Galbraith, C G AU - Yamada, K M AU - Galbraith, J A Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Membranes KW - Integrins KW - Actin KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39673028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Actin+Rockets+Guide+Membrane+Protrusion+and+Position+Primed+Integrins+to+Direct+Pathfinding&rft.au=Galbraith%2C+C+G%3BYamada%2C+K+M%3BGalbraith%2C+J+A&rft.aulast=Galbraith&rft.aufirst=C&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dissecting the Role of Rho-Mediated Signaling in Contractile Ring Formation T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39668551; 4032541 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Kamijo, K AU - Ohara, N AU - Abe, M AU - Uchimura, T AU - Hosoya, H AU - Lee, J AU - Miki, T Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Signal transduction KW - Contractility KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39668551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Dissecting+the+Role+of+Rho-Mediated+Signaling+in+Contractile+Ring+Formation&rft.au=Kamijo%2C+K%3BOhara%2C+N%3BAbe%2C+M%3BUchimura%2C+T%3BHosoya%2C+H%3BLee%2C+J%3BMiki%2C+T&rft.aulast=Kamijo&rft.aufirst=K&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Peroxisomal Membrane Protein, Pex16p, is Involved in the Formation Peroxisomes at the Endoplasmic Reticulum T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39637007; 4033186 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Kim, P K AU - Mullen, R T AU - Lippincott-Schwartz, J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Peroxisomal membrane protein KW - Peroxisomes KW - Endoplasmic reticulum KW - Membranes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39637007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Peroxisomal+Membrane+Protein%2C+Pex16p%2C+is+Involved+in+the+Formation+Peroxisomes+at+the+Endoplasmic+Reticulum&rft.au=Kim%2C+P+K%3BMullen%2C+R+T%3BLippincott-Schwartz%2C+J&rft.aulast=Kim&rft.aufirst=P&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Transmembrane Domain of the PC3: A Key Motif for Targeting to the Regulated Secretory Pathway T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39636956; 4033177 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Lou, H AU - Smith, A M AU - Coates, L C AU - Birch, N P AU - Loh, Y P Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Transmembrane domains KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39636956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Transmembrane+Domain+of+the+PC3%3A+A+Key+Motif+for+Targeting+to+the+Regulated+Secretory+Pathway&rft.au=Lou%2C+H%3BSmith%2C+A+M%3BCoates%2C+L+C%3BBirch%2C+N+P%3BLoh%2C+Y+P&rft.aulast=Lou&rft.aufirst=H&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bcl-XL Enhances the Effect of GM-CSF in the in Vitro Development of the Monocyte/Macrophage Lineage T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39636385; 4033406 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Antignani, A AU - Youle, R J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Granulocyte-macrophage colony-stimulating factor KW - Macrophages KW - Bcl-x protein KW - Monocytes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39636385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Bcl-XL+Enhances+the+Effect+of+GM-CSF+in+the+in+Vitro+Development+of+the+Monocyte%2FMacrophage+Lineage&rft.au=Antignani%2C+A%3BYoule%2C+R+J&rft.aulast=Antignani&rft.aufirst=A&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activities of Dolastatin 15 Peptide Analogs as Inhibitors of Tubulin Assembly and Vinblastine Binding T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39634706; 4032769 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Edler, M C AU - Bai, R AU - Hamel, E Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Vinblastine KW - Peptides KW - Analogs KW - Inhibitors KW - Tubulin KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39634706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Activities+of+Dolastatin+15+Peptide+Analogs+as+Inhibitors+of+Tubulin+Assembly+and+Vinblastine+Binding&rft.au=Edler%2C+M+C%3BBai%2C+R%3BHamel%2C+E&rft.aulast=Edler&rft.aufirst=M&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of Macroautophagy by Proteasome Inhibition in Living Cells T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39633683; 4034675 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Hailey, D W AU - Whiteman, E L AU - Lorenz, H AU - Lippincott-Schwartz, J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Proteasomes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39633683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Induction+of+Macroautophagy+by+Proteasome+Inhibition+in+Living+Cells&rft.au=Hailey%2C+D+W%3BWhiteman%2C+E+L%3BLorenz%2C+H%3BLippincott-Schwartz%2C+J&rft.aulast=Hailey&rft.aufirst=D&rft.date=2005-12-10&rft.volume=14&rft.issue=4&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nonverbal+Behavior&rft.issn=01915886&rft_id=info:doi/10.1007%2FBF00989320 L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Sulfation Pattern of Chondroitin Regulates Axonal Guidance T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39632645; 4034877 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Katagiri, Y AU - Wang, H AU - Geller, H M Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Axon guidance KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39632645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Differential+Sulfation+Pattern+of+Chondroitin+Regulates+Axonal+Guidance&rft.au=Katagiri%2C+Y%3BWang%2C+H%3BGeller%2C+H+M&rft.aulast=Katagiri&rft.aufirst=Y&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Neuroscience. Synaptic membranes bend to the will of a neurotoxin. AN - 68892494; 16339436 JF - Science (New York, N.Y.) AU - Zimmerberg, Joshua AU - Chernomordik, Leonid V AD - Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1855, USA. joshz@helix.nih.gov Y1 - 2005/12/09/ PY - 2005 DA - 2005 Dec 09 SP - 1626 EP - 1627 VL - 310 IS - 5754 KW - Fatty Acids KW - 0 KW - Lipid Bilayers KW - Lysophospholipids KW - Membrane Lipids KW - Micelles KW - Neurotoxins KW - Neurotransmitter Agents KW - Phospholipases A KW - EC 3.1.1.32 KW - Index Medicus KW - Animals KW - Neurotoxins -- metabolism KW - Membrane Lipids -- metabolism KW - Exocytosis KW - Mice KW - Neuromuscular Junction -- physiology KW - Neurotoxins -- toxicity KW - Hydrolysis KW - Neuromuscular Junction -- drug effects KW - Neurotransmitter Agents -- metabolism KW - Membrane Lipids -- analysis KW - Membrane Fusion KW - Synaptic Vesicles -- physiology KW - Phospholipases A -- toxicity KW - Synaptic Membranes -- chemistry KW - Lysophospholipids -- metabolism KW - Synaptic Membranes -- physiology KW - Phospholipases A -- metabolism KW - Fatty Acids -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68892494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28New+York%2C+N.Y.%29&rft.atitle=Neuroscience.+Synaptic+membranes+bend+to+the+will+of+a+neurotoxin.&rft.au=Zimmerberg%2C+Joshua%3BChernomordik%2C+Leonid+V&rft.aulast=Zimmerberg&rft.aufirst=Joshua&rft.date=2005-12-09&rft.volume=310&rft.issue=5754&rft.spage=1626&rft.isbn=&rft.btitle=&rft.title=Science+%28New+York%2C+N.Y.%29&rft.issn=1095-9203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-19 N1 - Date created - 2005-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Science. 2005 Dec 9;310(5754):1678-80 [16339444] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Multifunctional roles of the conserved Arg residues in the second region of homology of p97/valosin-containing protein. AN - 68859656; 16216872 AB - The 97-kDa molecular chaperone valosin-containing protein (VCP) belongs to a highly conserved AAA family and forms a hexameric structure that is essential for its biological functions. The AAA domain contains highly conserved motifs, the Walker A, Walker B, and the second region of homology (SRH). Although Walker A and B motifs mediate ATP binding and hydrolysis, respectively, the function of the SRH in VCP is not clear. We examined the significance of the SRH in VCP, especially the conserved Arg(359) and Arg(362) in the first AAA domain, D1 and Arg(635) and Arg(638) in the second AAA domain, D2. We show that Arg(359) and Arg(362) in D1 are critical for maintaining the hexameric structure and the ability to bind the polyubiquitin chains. Although the rest of the tested SRH mutants retain the hexameric structure, all of them exhibit severely reduced ATPase activity. Tryptophan fluorescence analysis showed that all of the tested mutants can bind to ATP or ADP. Thus, the reduced ATPase activity likely results from the hampered communications among protomers during hydrolysis. Moreover, when the ATPase-defective mutant R635A or R638A is mixed with the Walker A mutant of D2, the ATPase activity is partially restored, suggesting that Arg(635) and Arg(638) can stimulate the ATPase activity of the neighboring protomer. Interestingly, mutation of Arg(359) and Arg(362) uncouples the inhibitory effect of p47, a VCP co-factor, on the ATPase activity of VCP. Therefore, the Arg residues allow D1 to take on a specific conformation that is required for substrate binding and co-factor communications. Taken together, these results demonstrate that the conserved Arg residues in the SRH of both D1 and D2 play critical roles in communicating the conformational changes required for ATP hydrolysis, and SRH in D1 also contributes to substrate binding and co-factor communications. JF - The Journal of biological chemistry AU - Wang, Qing AU - Song, Changcheng AU - Irizarry, Lauren AU - Dai, Renming AU - Zhang, Xiaodong AU - Li, Chou-Chi H AD - Laboratory of Cancer Prevention, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA. qwang@ncifcrf.gov Y1 - 2005/12/09/ PY - 2005 DA - 2005 Dec 09 SP - 40515 EP - 40523 VL - 280 IS - 49 SN - 0021-9258, 0021-9258 KW - Cell Cycle Proteins KW - 0 KW - Recombinant Fusion Proteins KW - Polyubiquitin KW - 120904-94-1 KW - Tryptophan KW - 8DUH1N11BX KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Arginine KW - 94ZLA3W45F KW - Adenosine Triphosphatases KW - EC 3.6.1.- KW - CDC48 protein KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Polyubiquitin -- metabolism KW - Spectrometry, Fluorescence KW - Adenosine Triphosphate -- metabolism KW - Molecular Sequence Data KW - Adenosine Triphosphatases -- metabolism KW - Amino Acid Sequence KW - Tryptophan -- chemistry KW - Hydrolysis KW - Adenosine Triphosphatases -- genetics KW - Structure-Activity Relationship KW - Protein Conformation KW - Cell Cycle Proteins -- physiology KW - Cell Cycle Proteins -- chemistry KW - Conserved Sequence KW - Cell Cycle Proteins -- genetics KW - Arginine -- genetics KW - Arginine -- chemistry KW - Arginine -- physiology KW - Sequence Homology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68859656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Multifunctional+roles+of+the+conserved+Arg+residues+in+the+second+region+of+homology+of+p97%2Fvalosin-containing+protein.&rft.au=Wang%2C+Qing%3BSong%2C+Changcheng%3BIrizarry%2C+Lauren%3BDai%2C+Renming%3BZhang%2C+Xiaodong%3BLi%2C+Chou-Chi+H&rft.aulast=Wang&rft.aufirst=Qing&rft.date=2005-12-09&rft.volume=280&rft.issue=49&rft.spage=40515&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-06 N1 - Date created - 2005-12-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Induction of apoptosis in human leukemia cells by black tea and its polyphenol theaflavin. AN - 68734903; 16253767 AB - Treatment of human leukemic cell lines HL-60 and K-562 with extracts of green and black tea and their polyphenols epigallocatechin gallate and theaflavins, respectively, showed a dose dependent inhibition of growth as a result of cytotoxicity and suppression of cell proliferation. Based on the IC50 values obtained from cytotoxicity data it was clearly evident that black tea was as efficient as green tea. Analysis of polyphenol contents of tea extracts revealed that not only epigallocatechin gallate, which is a predominant polyphenol of green tea, but also theaflavin that is abundantly present in black tea affords significant chemotherapeutic action by imparting cytotoxicity to human leukemic cells. Electrophoretic analysis of fragmented DNA from treated cells displayed characteristic ladder pattern. Flow cytometric analysis revealed the dose dependent increase in sub-G1 peak. These criteria confirmed that cytotoxic activity of green and black tea was due to induction of apoptosis. Such induction was found to be mediated through activation of caspases 3 and 8, particularly caspase 3 and by altering apoptosis related genes as evident by down-regulation of Bcl-2 and up-regulation of Bax proteins. JF - Cancer letters AU - Kundu, Trina AU - Dey, Subhabrata AU - Roy, Madhumita AU - Siddiqi, M AU - Bhattacharya, R K AD - Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, 37 S.P. Mukherjee Road, Kolkata 700 026, India. Y1 - 2005/12/08/ PY - 2005 DA - 2005 Dec 08 SP - 111 EP - 121 VL - 230 IS - 1 SN - 0304-3835, 0304-3835 KW - Antioxidants KW - 0 KW - Biflavonoids KW - Flavonoids KW - Phenols KW - Polyphenols KW - Tea KW - bcl-2-Associated X Protein KW - theaflavin KW - 1IA46M0D13 KW - Catechin KW - 8R1V1STN48 KW - CASP3 protein, human KW - EC 3.4.22.- KW - CASP8 protein, human KW - Caspase 3 KW - Caspase 8 KW - Caspases KW - Index Medicus KW - Phenols -- pharmacology KW - HL-60 Cells KW - Humans KW - Caspases -- metabolism KW - Phenols -- analysis KW - Flavonoids -- analysis KW - Genes, bcl-2 KW - Down-Regulation KW - Flow Cytometry KW - Caspases -- drug effects KW - Flavonoids -- pharmacology KW - Antioxidants -- pharmacology KW - Apoptosis -- drug effects KW - Biflavonoids -- pharmacology KW - Tea -- chemistry KW - Catechin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68734903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Induction+of+apoptosis+in+human+leukemia+cells+by+black+tea+and+its+polyphenol+theaflavin.&rft.au=Kundu%2C+Trina%3BDey%2C+Subhabrata%3BRoy%2C+Madhumita%3BSiddiqi%2C+M%3BBhattacharya%2C+R+K&rft.aulast=Kundu&rft.aufirst=Trina&rft.date=2005-12-08&rft.volume=230&rft.issue=1&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-23 N1 - Date created - 2005-10-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Diphenylmethyl selenocyanate inhibits DMBA-croton oil induced two-stage mouse skin carcinogenesis by inducing apoptosis and inhibiting cutaneous cell proliferation. AN - 68733085; 16253765 AB - Numerous epidemiological and experimental studies have showed the inverse relationship between dietary selenium intake and different types of cancer. Continuous efforts are going on to develop suitable organoselenium compounds, which can be used as cancer chemopreventive agents for human. In the present study, a synthetic organoselenium compound diphenylmethyl selenocyanate was evaluated for its ability to arrest cell proliferation and to induce apoptosis against 7,12-dimethylbenz[a]anthracene-croton oil induced two-stage mouse skin carcinogenesis model. Reduction in the incidence and number of papilloma, the preneoplastic lesion, was considered to be the mean of assessment. Significant decrease in the level of cell proliferation (p<0.01) and significant enhancement in the level of apoptosis (p<0.01) were found. Caspase-3, which contribute a part in the process of cellular apoptosis to prevent further cellular differentiation was also elevated significantly (P<0.01) during the treatment with the Se compound. These observations seem to be correlated with the significant reduction in the corresponding number of skin papilloma formation after 12 weeks of experiment. Thus the compound, diphenylmethyl selenocyanate may be considered for further research to establish it as an effective cancer chemopreventive agent. JF - Cancer letters AU - Das, Rajat Kumar AU - Hossain, S K Ugir AU - Bhattacharya, Sudin AD - Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700 026, India. Y1 - 2005/12/08/ PY - 2005 DA - 2005 Dec 08 SP - 90 EP - 101 VL - 230 IS - 1 SN - 0304-3835, 0304-3835 KW - Carcinogens KW - 0 KW - Dermatologic Agents KW - Organoselenium Compounds KW - diphenylmethyl selenocyanate KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Croton Oil KW - 8001-28-3 KW - CASP3 protein, human KW - EC 3.4.22.- KW - Casp3 protein, mouse KW - Caspase 3 KW - Caspases KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Animals KW - Caspases -- analysis KW - Apoptosis -- drug effects KW - Caspases -- biosynthesis KW - Mice KW - Chemoprevention KW - Female KW - Skin Neoplasms -- physiopathology KW - Organoselenium Compounds -- pharmacology KW - Croton Oil -- toxicity KW - Papilloma -- prevention & control KW - 9,10-Dimethyl-1,2-benzanthracene -- toxicity KW - Skin Neoplasms -- chemically induced KW - Carcinogens -- toxicity KW - Papilloma -- physiopathology KW - Skin Neoplasms -- prevention & control KW - Papilloma -- chemically induced KW - Dermatologic Agents -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68733085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Diphenylmethyl+selenocyanate+inhibits+DMBA-croton+oil+induced+two-stage+mouse+skin+carcinogenesis+by+inducing+apoptosis+and+inhibiting+cutaneous+cell+proliferation.&rft.au=Das%2C+Rajat+Kumar%3BHossain%2C+S+K+Ugir%3BBhattacharya%2C+Sudin&rft.aulast=Das&rft.aufirst=Rajat&rft.date=2005-12-08&rft.volume=230&rft.issue=1&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-23 N1 - Date created - 2005-10-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adjuvant chemotherapy for stage III colon cancer: implications of race/ethnicity, age, and differentiation. AN - 68879390; 16333005 AB - A 1990 National Institutes of Health Consensus Conference recommended that patients with stage III colon cancer receive adjuvant chemotherapy because survival was improved in clinical trials in patients who received a 5-fluorouracil-based regimen. To determine whether adjuvant chemotherapy is used in the community as a standard of practice that improves outcome and whether it failed to benefit any specific sets of patients. Prospective data from 85 934 patients with stage III colon cancer from 560 hospital cancer registries were entered into the National Cancer Data Base between 1990 and 2002 and included standard clinical, pathological, and first course of treatment variables. Prevalence of adjuvant chemotherapy usage and 5-year survival in patients treated in US hospitals. Adjuvant chemotherapy use increased from 39% in 1991 to 64% in 2002 but was lower in black, female, and elderly patients. It improved 5-year survival from almost 8% in 1991 to more than 16% in 1997 compared with surgery alone. Adjuvant chemotherapy increases survival in elderly patients as much as it does in younger patients. However, the benefit of adjuvant chemotherapy in blacks and those with high-grade cancers is not as great. Adjuvant chemotherapy use has increased from 1990 to 2002 for patients with stage III colon cancer with an associated increase in 5-year survival of 16%. The benefit of adjuvant chemotherapy seems to be lower in black patients and high-grade cancers. Women have the same benefit but are less often treated. Elderly patients have the same benefit as younger patients but are less frequently treated. New options for adjuvant therapy in 2004-2005 may further improve the outcome of patients with stage III colon cancer. JF - JAMA AU - Jessup, J Milburn AU - Stewart, Andrew AU - Greene, Frederick L AU - Minsky, Bruce D AD - Department of Oncology, Georgetown University Medical Center, Washington, DC, USA. jessupj@mail.nih.gov Y1 - 2005/12/07/ PY - 2005 DA - 2005 Dec 07 SP - 2703 EP - 2711 VL - 294 IS - 21 KW - Adjuvants, Immunologic KW - 0 KW - Antimetabolites, Antineoplastic KW - Levamisole KW - 2880D3468G KW - Fluorouracil KW - U3P01618RT KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Age Factors KW - Sex Factors KW - Neoplasm Staging KW - Humans KW - Prognosis KW - Aged KW - European Continental Ancestry Group -- statistics & numerical data KW - African Continental Ancestry Group -- statistics & numerical data KW - Drug Utilization KW - Fluorouracil -- therapeutic use KW - Aged, 80 and over KW - Middle Aged KW - Antimetabolites, Antineoplastic -- therapeutic use KW - Male KW - Adjuvants, Immunologic -- therapeutic use KW - Female KW - Survival Analysis KW - Proportional Hazards Models KW - Levamisole -- therapeutic use KW - Chemotherapy, Adjuvant -- utilization KW - Colonic Neoplasms -- mortality KW - Colonic Neoplasms -- drug therapy KW - Colonic Neoplasms -- ethnology KW - Colonic Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68879390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Adjuvant+chemotherapy+for+stage+III+colon+cancer%3A+implications+of+race%2Fethnicity%2C+age%2C+and+differentiation.&rft.au=Jessup%2C+J+Milburn%3BStewart%2C+Andrew%3BGreene%2C+Frederick+L%3BMinsky%2C+Bruce+D&rft.aulast=Jessup&rft.aufirst=J&rft.date=2005-12-07&rft.volume=294&rft.issue=21&rft.spage=2703&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=1538-3598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-09 N1 - Date created - 2005-12-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: JAMA. 2005 Dec 7;294(21):2758-60 [16333012] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toll-like receptor 4 in butylated hydroxytoluene-induced mouse pulmonary inflammation and tumorigenesis. AN - 68874081; 16333033 AB - Because chronic pulmonary diseases predispose to lung neoplasia, the identification of the molecular mechanisms involved could provide novel preventive, diagnostic, and therapeutic strategies. Toll-like receptors (TLRs) transduce exogenous and endogenous signals into the production of inflammatory cytokines to coordinate adaptive immune responses. To determine the role of Tlr4 in chronic lung inflammation, we compared lung permeability, leukocyte infiltration, and nuclear factor kappa B (NFkappaB) and activator protein 1 (AP-1) DNA binding in butylated hydroxytoluene (BHT)-treated (four weekly injections of 125-200 mg/kg each) inbred mouse strains with functional Tlr4 (OuJ and BALB) and mutated Tlr4 (HeJ and BALB(Lps-d)). We also measured primary tumor formation in these mice after single-carcinogen injection (3-methylcholanthrene; 10 microg/kg), followed by BHT treatment (six weekly injections of 125-200 mg/kg each). Mice with functional Tlr4 had reduced lung permeability, leukocyte inflammation, and primary tumor formation (BALB(Lps-d), mean = 22.3 tumors/mouse, versus BALB, mean = 13.9 tumors/mouse, difference = 8.4 tumors/mouse, 95% confidence interval = 4.6 to 12.1 tumors/mouse; P = .025) compared with mice with mutated Tlr4. NFkappaB DNA binding activity was higher in OuJ than in HeJ mice; however, AP-1 activity was elevated in HeJ mice. To our knowledge, this is the first model to demonstrate a modulatory role for Tlr4 in chronic lung inflammation and tumorigenesis. JF - Journal of the National Cancer Institute AU - Bauer, Alison K AU - Dixon, Darlene AU - DeGraff, Laura M AU - Cho, Hye-Youn AU - Walker, Christopher R AU - Malkinson, Alvin M AU - Kleeberger, Steven R AD - Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. bauer1@niehs.nih.gov Y1 - 2005/12/07/ PY - 2005 DA - 2005 Dec 07 SP - 1778 EP - 1781 VL - 97 IS - 23 KW - NF-kappa B KW - 0 KW - Tlr4 protein, mouse KW - Toll-Like Receptor 4 KW - Transcription Factor AP-1 KW - Butylated Hydroxytoluene KW - 1P9D0Z171K KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Transcription Factor AP-1 -- metabolism KW - Disease Models, Animal KW - Mice KW - Mutation KW - NF-kappa B -- metabolism KW - Pneumonia -- chemically induced KW - Toll-Like Receptor 4 -- genetics KW - Toll-Like Receptor 4 -- metabolism KW - Lung Neoplasms -- chemically induced KW - Pneumonia -- metabolism KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68874081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Toll-like+receptor+4+in+butylated+hydroxytoluene-induced+mouse+pulmonary+inflammation+and+tumorigenesis.&rft.au=Bauer%2C+Alison+K%3BDixon%2C+Darlene%3BDeGraff%2C+Laura+M%3BCho%2C+Hye-Youn%3BWalker%2C+Christopher+R%3BMalkinson%2C+Alvin+M%3BKleeberger%2C+Steven+R&rft.aulast=Bauer&rft.aufirst=Alison&rft.date=2005-12-07&rft.volume=97&rft.issue=23&rft.spage=1778&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-15 N1 - Date created - 2005-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mutational analysis of the Arf1*GTP/Arf GAP interface reveals an Arf1 mutant that selectively affects the Arf GAP ASAP1. AN - 68876671; 16332543 AB - Arf1 is a GTP binding protein that functions at a number of cellular sites to control membrane traffic and actin remodeling. Arf1 is regulated by site-specific GTPase-activating proteins (GAPs). The combined results of crystallographic and biochemical studies have led to the proposal that Arf1 GAPs differ in the specific interface formed with Arf1. To test this hypothesis, we have used mutagenesis to examine the interaction of three Arf GAPs (ASAP1, AGAP1, and ArfGAP1) with switch 1, switch 2, and alpha helix3 of Arf1. The GAPs were similar in being affected by mutations in switch 1 and 2. However, effects of a mutation within alpha helix3 and specific mutations within switch 1 and 2 differed among the GAPs. The largest differences were observed with a change of isoleucine 46 to aspartate ([I46D]Arf1), which reduced ASAP1-induced catalysis by approximately 10,000-fold but had a 3-fold effect on AGAP1. The reduction was due to an isolated effect on the catalytic rate, k(cat). In vivo [I46D]Arf1 had no detectable effect on the Golgi apparatus but, instead, functioned as a constitutively active mutant in the cell periphery, affecting the localization of ASAP1 and paxillin. Based on our results, we conclude that the contribution of specific residues within switch 1 of Arf to binding and achieving a transition state toward GTP hydrolysis differs among Arf GAPs. JF - Current biology : CB AU - Luo, Ruibai AU - Jacques, Kerry AU - Ahvazi, Bijan AU - Stauffer, Stacey AU - Premont, Richard T AU - Randazzo, Paul A AD - Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2005/12/06/ PY - 2005 DA - 2005 Dec 06 SP - 2164 EP - 2169 VL - 15 IS - 23 SN - 0960-9822, 0960-9822 KW - AGAP1 protein, human KW - 0 KW - ASAP1 protein, human KW - Adaptor Proteins, Signal Transducing KW - GTPase-Activating Proteins KW - Guanosine Triphosphate KW - 86-01-1 KW - ADP-Ribosylation Factor 1 KW - EC 3.6.5.2 KW - ADP-Ribosylation Factors KW - Index Medicus KW - Animals KW - Humans KW - DNA Mutational Analysis KW - Mutation -- genetics KW - Mice KW - Golgi Apparatus -- metabolism KW - Fluorescent Antibody Technique KW - NIH 3T3 Cells KW - Guanosine Triphosphate -- metabolism KW - Catalysis KW - Adaptor Proteins, Signal Transducing -- metabolism KW - GTPase-Activating Proteins -- metabolism KW - Models, Molecular KW - ADP-Ribosylation Factors -- metabolism KW - ADP-Ribosylation Factor 1 -- metabolism KW - ADP-Ribosylation Factor 1 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68876671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+biology+%3A+CB&rft.atitle=Mutational+analysis+of+the+Arf1*GTP%2FArf+GAP+interface+reveals+an+Arf1+mutant+that+selectively+affects+the+Arf+GAP+ASAP1.&rft.au=Luo%2C+Ruibai%3BJacques%2C+Kerry%3BAhvazi%2C+Bijan%3BStauffer%2C+Stacey%3BPremont%2C+Richard+T%3BRandazzo%2C+Paul+A&rft.aulast=Luo&rft.aufirst=Ruibai&rft.date=2005-12-06&rft.volume=15&rft.issue=23&rft.spage=2164&rft.isbn=&rft.btitle=&rft.title=Current+biology+%3A+CB&rft.issn=09609822&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-12 N1 - Date created - 2005-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - The "Binding Site Barrier" and other Factors that Limit Antibody Penetration into Tumors T2 - 16th Annual International Antibody Engineering Conference (Antibody Engineering) AN - 39828293; 4041305 JF - 16th Annual International Antibody Engineering Conference (Antibody Engineering) AU - Weinstein, John N Y1 - 2005/12/05/ PY - 2005 DA - 2005 Dec 05 KW - Barriers KW - Antibodies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39828293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Annual+International+Antibody+Engineering+Conference+%28Antibody+Engineering%29&rft.atitle=The+%22Binding+Site+Barrier%22+and+other+Factors+that+Limit+Antibody+Penetration+into+Tumors&rft.au=Weinstein%2C+John+N&rft.aulast=Weinstein&rft.aufirst=John&rft.date=2005-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Annual+International+Antibody+Engineering+Conference+%28Antibody+Engineering%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ibclifesciences.com/antibodyeng LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Integrating Hypothesis-Driven and "Omic" Approaches to Cancer Biology, Biomarkers, and Therapeutics T2 - 16th Annual International Antibody Engineering Conference (Antibody Engineering) AN - 39752940; 4041290 JF - 16th Annual International Antibody Engineering Conference (Antibody Engineering) AU - Weinstein, John N Y1 - 2005/12/05/ PY - 2005 DA - 2005 Dec 05 KW - Bioindicators KW - Biomarkers KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39752940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Annual+International+Antibody+Engineering+Conference+%28Antibody+Engineering%29&rft.atitle=Integrating+Hypothesis-Driven+and+%22Omic%22+Approaches+to+Cancer+Biology%2C+Biomarkers%2C+and+Therapeutics&rft.au=Weinstein%2C+John+N&rft.aulast=Weinstein&rft.aufirst=John&rft.date=2005-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Annual+International+Antibody+Engineering+Conference+%28Antibody+Engineering%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ibclifesciences.com/antibodyeng LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Error-prone translesion synthesis by human DNA polymerase eta on DNA-containing deoxyadenosine adducts of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene. AN - 68839904; 16188888 AB - When human DNA polymerase eta (pol eta) encounters N6-deoxyadenosine adducts formed by trans epoxide ring opening of the 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BaP DE) isomer with (+)-7R,8S,9S,10R configuration ((+)-BaP DE-2), misincorporation of A or G and incorporation of the correct T are equally likely to occur. On the other hand, the enzyme exhibits a 3-fold preference for correct T incorporation opposite adducts formed by trans ring opening of the (-)-(7S,8R,9R,10S)-DE-2 enantiomer. Adducts at dA formed by cis ring opening of these two BaP DE-2 isomers exhibit a 2-3-fold preference for A over T incorporation, with G intermediate between the two. Extension one nucleotide beyond these adducts is generally weaker than incorporation across from them, but among mismatches the (adducted A*) x A mispair is the most favored for extension. Because mutations can only occur if mispairs are extended, this observation is consistent with the occurrence of A x T to T x A transversions as common mutations in animal cells treated with BaP DE-2 isomers. Adducts with S absolute configuration at the point of attachment of the hydrocarbon to the base inhibit incorporation and extension by pol eta to a lesser extent than their R counterparts. Template-primers containing each of the four isomeric dA adducts derived from BaP DE-2 and two adducts derived from 9,10-epoxy-7,8,9,10-tetrahydrobenzo-[a]pyrene in which the 7- and 8-hydroxyl groups of the DEs are replaced with hydrogens exhibit reduced electrophoretic mobilities relative to the unadducted oligonucleotides. This effect is largely independent of DNA sequence. Decreased mobility correlates with an increased rate of incorporation by pol eta, suggesting a systematic relationship between the overall DNA structure and efficiency of the enzyme. JF - The Journal of biological chemistry AU - Chiapperino, Dominic AU - Cai, Mangmang AU - Sayer, Jane M AU - Yagi, Haruhiko AU - Kroth, Heiko AU - Masutani, Chikahide AU - Hanaoka, Fumio AU - Jerina, Donald M AU - Cheh, Albert M AD - Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, DHHS, Bethesda, Maryland 20892, USA. Y1 - 2005/12/02/ PY - 2005 DA - 2005 Dec 02 SP - 39684 EP - 39692 VL - 280 IS - 48 SN - 0021-9258, 0021-9258 KW - DNA Adducts KW - 0 KW - DNA Primers KW - Deoxyadenosines KW - Hydrocarbons KW - Oligonucleotides KW - 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide KW - 55097-80-8 KW - Hydrogen KW - 7YNJ3PO35Z KW - DNA KW - 9007-49-2 KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Rad30 protein KW - Index Medicus KW - Hydrocarbons -- chemistry KW - Oligonucleotides -- chemistry KW - Hydrogen -- chemistry KW - Electrophoresis, Polyacrylamide Gel KW - Kinetics KW - Humans KW - Models, Chemical KW - Sequence Analysis, DNA KW - Nucleic Acid Conformation KW - Mutation KW - DNA Primers -- chemistry KW - DNA-Directed DNA Polymerase -- physiology KW - DNA Repair KW - Base Pair Mismatch KW - DNA -- chemistry KW - Deoxyadenosines -- chemistry KW - 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide -- chemistry KW - DNA-Directed DNA Polymerase -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68839904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Error-prone+translesion+synthesis+by+human+DNA+polymerase+eta+on+DNA-containing+deoxyadenosine+adducts+of+7%2C8-dihydroxy-9%2C10-epoxy-7%2C8%2C9%2C10-tetrahydrobenzo%5Ba%5Dpyrene.&rft.au=Chiapperino%2C+Dominic%3BCai%2C+Mangmang%3BSayer%2C+Jane+M%3BYagi%2C+Haruhiko%3BKroth%2C+Heiko%3BMasutani%2C+Chikahide%3BHanaoka%2C+Fumio%3BJerina%2C+Donald+M%3BCheh%2C+Albert+M&rft.aulast=Chiapperino&rft.aufirst=Dominic&rft.date=2005-12-02&rft.volume=69&rft.issue=2&rft.spage=430&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Politics&rft.issn=00223816&rft_id=info:doi/10.1111%2Fj.1468-2508.2007.00541.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-03 N1 - Date created - 2005-11-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reactive oxygen species and p38 phosphorylation regulate the protective effect of Delta9-tetrahydrocannabinol in the apoptotic response to NMDA. AN - 68554545; 16098661 AB - NMDA causes oxidative stress in neurons, and produces cell death involving elements of both necrosis and apoptosis. To examine the neuroprotective mechanism of Delta9-tetrahydrocannabinol (THC) in NMDA-induced death of AF5 cells, we measured reactive oxygen species (ROS) formation after exposure to NMDA. ROS generation was increased by NMDA, and NMDA-induced ROS generation was significantly decreased by THC. Western blotting revealed an increase in phosphorylated p38 MAPK after NMDA treatment, which was also blocked by pretreatment with THC. The time course of ROS generation and activation of MAPK signaling pathways were similar. SB203580, a p38 inhibitor, partially blocked glutamate excitotoxicity in AF5 cells. The present data suggest that THC protects against NMDA-induced apoptosis in AF5 cells by blocking ROS generation and inhibiting the activation of p38-MAPK. JF - Neuroscience letters AU - Chen, Jia AU - Errico, Stacie L AU - Freed, William J AD - Development and Plasticity Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA. jchen@intra.nida.nih.gov Y1 - 2005/12/02/ PY - 2005 DA - 2005 Dec 02 SP - 99 EP - 103 VL - 389 IS - 2 SN - 0304-3940, 0304-3940 KW - Enzyme Inhibitors KW - 0 KW - Neuroprotective Agents KW - Neurotoxins KW - Reactive Oxygen Species KW - N-Methylaspartate KW - 6384-92-5 KW - Dronabinol KW - 7J8897W37S KW - p38 Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Animals KW - MAP Kinase Signaling System -- drug effects KW - Neurodegenerative Diseases -- physiopathology KW - MAP Kinase Signaling System -- physiology KW - Dose-Response Relationship, Drug KW - Enzyme Activation -- physiology KW - Phosphorylation -- drug effects KW - Neuroprotective Agents -- pharmacology KW - Oxidative Stress -- physiology KW - Cell Survival -- drug effects KW - Neurodegenerative Diseases -- metabolism KW - Oxidative Stress -- drug effects KW - Enzyme Activation -- drug effects KW - Enzyme Inhibitors -- pharmacology KW - Cell Line, Transformed KW - Cell Survival -- physiology KW - Reactive Oxygen Species -- metabolism KW - p38 Mitogen-Activated Protein Kinases -- antagonists & inhibitors KW - Dronabinol -- pharmacology KW - Apoptosis -- physiology KW - Apoptosis -- drug effects KW - N-Methylaspartate -- toxicity KW - N-Methylaspartate -- antagonists & inhibitors KW - Neurotoxins -- toxicity KW - p38 Mitogen-Activated Protein Kinases -- metabolism KW - Neurotoxins -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68554545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Reactive+oxygen+species+and+p38+phosphorylation+regulate+the+protective+effect+of+Delta9-tetrahydrocannabinol+in+the+apoptotic+response+to+NMDA.&rft.au=Chen%2C+Jia%3BErrico%2C+Stacie+L%3BFreed%2C+William+J&rft.aulast=Chen&rft.aufirst=Jia&rft.date=2005-12-02&rft.volume=389&rft.issue=2&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=03043940&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-24 N1 - Date created - 2005-09-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Physiol Heart Circ Physiol. 2003 Aug;285(2):H822-32 [12714335] Neurosci Res. 2003 Jul;46(3):349-58 [12804796] J Neurochem. 2003 Feb;84(3):566-75 [12558976] J Cell Physiol. 2002 Jul;192(1):1-15 [12115731] Exp Neurol. 2002 Jun;175(2):318-37 [12061863] J Neurochem. 2002 Feb;80(3):448-56 [11905991] Neurochem Res. 2001 May;26(5):525-32 [11513480] J Neurochem. 2001 May;77(3):957-60 [11331425] J Neurosci. 2000 Aug 1;20(15):5715-23 [10908611] Mol Pharmacol. 2000 Oct;58(4):814-20 [10999952] J Physiol. 2001 Feb 15;531(Pt 1):147-63 [11179399] Trends Pharmacol Sci. 1999 Nov;20(11):441-4 [10542441] Neuroreport. 2003 Oct 6;14(14):1815-9 [14534426] Exp Cell Res. 2003 Nov 15;291(1):251-66 [14597424] Neurosci Lett. 1986 May 15;66(2):193-8 [3014386] Brain Res Mol Brain Res. 2005 Apr 4;134(2):215-25 [15836919] Anesth Analg. 2005 Apr;100(4):929-36 [15781500] Rev Pneumol Clin. 2005 Feb;61(1 Pt 1):16-21 [15772575] Mol Cell Neurosci. 2005 Jan;28(1):189-94 [15607953] Annu Rev Physiol. 1998;60:619-42 [9558479] J Biol Chem. 1997 Jul 25;272(30):18518-21 [9228012] Neuron. 1995 Feb;14(2):303-15 [7857640] FEBS Lett. 1995 May 8;364(2):229-33 [7750577] J Biol Chem. 1986 Oct 25;261(30):14201-8 [2876985] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Distinct Protein Classes Including Novel Merozoite Surface Antigens in Raft-like Membranes of Plasmodium falciparum AN - 20254325; 7143458 AB - Glycosylphosphatidylinositol (GPI)-anchored proteins coat the surface of extracellular Plasmodium falciparum merozoites, of which several are highly validated candidates for inclusion in a blood-stage malaria vaccine. Here we determined the proteome of gradient-purified detergent-resistant membranes of mature blood-stage parasites and found that these membranes are greatly enriched in GPI-anchored proteins and their putative interacting partners. Also prominent in detergent-resistant membranes are apical organelle (rhoptry), multimembrane-spanning, and proteins destined for export into the host erythrocyte cytosol. Four new GPI-anchored proteins were identified, and a number of other novel proteins that are predicted to localize to the merozoite surface and/or apical organelles were detected. Three of the putative surface proteins possessed six-cysteine (Cys sub(6)) motifs, a distinct fold found in adhesive surface proteins expressed in other life stages. All three Cys sub(6) proteins, termed Pf12, Pf38, and Pf41, were validated as merozoite surface antigens recognized strongly by antibodies present in naturally infected individuals. In addition to the merozoite surface, Pf38 was particularly prominent in the secretory apical organelles. A different cysteine-rich putative GPI-anchored protein, Pf92, was also localized to the merozoite surface. This insight into merozoite surfaces provides new opportunities for understanding both erythrocyte invasion and anti-parasite immunity. JF - Journal of Biological Chemistry AU - Sanders, Paul R AU - Gilson, Paul R AU - Cantin, Greg T AU - Greenbaum, Doron C AU - Nebl, Thomas AU - Carucci, Daniel J AU - McConville, Malcolm J AU - Schofield, Louis AU - Hodder, Anthony N AU - Yates, John RIII AU - Crabb, Brendan S AD - The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3050 Australia, The Co-operative Research Centre for Vaccine Technology, Australia and the Department of Medical Biology, The University of Melbourne, VIC 3010 Australia, the Department of Cell Biology, The Scripps Research Institute, La, Jolla, California 92037, The Foundation for the National Institutes of Health, Bethesda, Maryland 20814, and the Department of Biochemistry and Molecular Biology, The University of Melbourne, VIC 3050 Australia Y1 - 2005/12/02/ PY - 2005 DA - 2005 Dec 02 SP - 40169 EP - 40176 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org] VL - 280 IS - 48 SN - 0021-9258, 0021-9258 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Parasites KW - Human diseases KW - Erythrocytes KW - Disease control KW - Malaria KW - Antigens KW - Protein folding KW - Glycosylphosphatidylinositol KW - Adhesives KW - Protein transport KW - Developmental stages KW - Plasmodium falciparum KW - Immunity KW - Antibodies KW - surface antigens KW - Cytosol KW - Merozoites KW - Vaccines KW - Organelles KW - K 03330:Biochemistry KW - W 30915:Pharmaceuticals & Vaccines KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20254325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Distinct+Protein+Classes+Including+Novel+Merozoite+Surface+Antigens+in+Raft-like+Membranes+of+Plasmodium+falciparum&rft.au=Sanders%2C+Paul+R%3BGilson%2C+Paul+R%3BCantin%2C+Greg+T%3BGreenbaum%2C+Doron+C%3BNebl%2C+Thomas%3BCarucci%2C+Daniel+J%3BMcConville%2C+Malcolm+J%3BSchofield%2C+Louis%3BHodder%2C+Anthony+N%3BYates%2C+John+RIII%3BCrabb%2C+Brendan+S&rft.aulast=Sanders&rft.aufirst=Paul&rft.date=2005-12-02&rft.volume=280&rft.issue=48&rft.spage=40169&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Parasites; Human diseases; Antigens; Erythrocytes; Disease control; Malaria; Immunity; Vaccines; Protein transport; Developmental stages; Antibodies; Protein folding; surface antigens; Cytosol; Merozoites; Glycosylphosphatidylinositol; Organelles; Adhesives; Plasmodium falciparum ER - TY - JOUR T1 - Conservation and variation of gene regulation in embryonic stem cells assessed by comparative genomics AN - 864949249; 13857308 AB - We have examined the gene structure and regulatory regions of octamer-binding transcription factor 3/4 (Oct 3/4), sex determining region Y box 2 (Sox2), signal transducer and activator of transcription 3 (Stat3), embryonal stem cell-specific gene 1 (ESG), nanog homeobox (Nanog), and several other genes highly expressed in embryonic stem (ES) cells across different species. Our analysis showed that ES cell-expressed Ras (ERAS) was orthologous to a human pseudogene Harvey Ras (HRASP) and that the promoter and other regulatory sequences were highly divergent. No ortholog of (ES) cell-derived homeobox containing gene (Ehox) could be identified in human, and the closest paralogs PEPP gene subfamily 1 (PEPP1), PEPP2, and extraembryonic, spermatogenesis, homeobox 1 (Esx1) were not expressed by ES cells and shared little homology. The Sox2 promoter was the most conserved across species and the Oct3/4 promoter region showed significant homology particularly in the distal enhancer active in ES cells. Analysis suggested common and divergent pathways of regulation. Conserved Oct3/4 and Sox2 co-binding domains were identified in most ES expressed genes, highlighting the importance of this transcriptional pathway. Conserved fibroblast growth factor response element sites were identified in regulatory regions, suggesting a potential parallel pathway for regulation by FGFs. A central role of Stat3 activation in self-renewal and in a regulatory feedback loop was suggested by the identification of the conserved binding sites in most pathways. Although most pathways were evolutionarily conserved, promoters and genomic structure of the leukemia inhibitory factor (LIF) pathway components were divergent, likely explaining the differential requirement of LIF for human and rodent cells. Our analysis further suggested that the Nanog regulatory pathway was relatively independent of the LIF/Oct pathway and may interact with the Nodal/transforming growth factor-b pathway. These results provide a framework for examining the current reported differences between rodent and human ES cells and define targets for future perturbation studies. JF - Cell Biochemistry and Biophysics AU - Zhan, Ming AU - Miura, Takumi AU - Xu, Xiangru AU - Rao, Mahendra S AD - Stem Cell Section, Laboratory of Neurosciences, National Institute on Aging, NIH, 21224, Baltimore, MD Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 379 EP - 405 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 43 IS - 3 SN - 1085-9195, 1085-9195 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Ras protein KW - Pseudogenes KW - Stat3 protein KW - Leukemia inhibitory factor KW - Regulatory sequences KW - Homeobox KW - Spermatogenesis KW - Promoters KW - Enhancers KW - Stem cells KW - Homology KW - Embryo cells KW - Gene regulation KW - Transcription factors KW - Fibroblast growth factor KW - Transforming growth factor- beta KW - Conservation KW - Transforming growth factor-b KW - Feedback KW - genomics KW - Oct-4 protein KW - Evolution KW - Sex KW - N 14835:Protein-Nucleic Acids Association KW - G 07730:Development & Cell Cycle KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864949249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+Biochemistry+and+Biophysics&rft.atitle=Conservation+and+variation+of+gene+regulation+in+embryonic+stem+cells+assessed+by+comparative+genomics&rft.au=Zhan%2C+Ming%3BMiura%2C+Takumi%3BXu%2C+Xiangru%3BRao%2C+Mahendra+S&rft.aulast=Zhan&rft.aufirst=Ming&rft.date=2005-12-01&rft.volume=43&rft.issue=3&rft.spage=379&rft.isbn=&rft.btitle=&rft.title=Cell+Biochemistry+and+Biophysics&rft.issn=10859195&rft_id=info:doi/10.1385%2FCBB%3A43%3A3%3A379 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Ras protein; Pseudogenes; Leukemia inhibitory factor; Stat3 protein; Regulatory sequences; Homeobox; Spermatogenesis; Enhancers; Promoters; Stem cells; Embryo cells; Homology; Transcription factors; Gene regulation; Transforming growth factor- beta; Fibroblast growth factor; Transforming growth factor-b; Conservation; Feedback; genomics; Oct-4 protein; Evolution; Sex DO - http://dx.doi.org/10.1385/CBB:43:3:379 ER - TY - JOUR T1 - Automatic Priming of Semantically Related Words Reduces Activity in the Fusiform Gyrus AN - 85632733; 200609750 AB - We used rapid, event-related fMRI to identify the neural systems underlying object semantics. During scanning, subjects silently read rapidly presented word pairs (150 msec, SOA = 250 msec) that were either unrelated in meaning (ankle-carrot), semantically related (fork-cup), or identical (crow-crow). Activity in the left posterior region of the fusiform gyrus & left inferior frontal cortex was modulated by word-pair relationship. Semantically related pairs yielded less activity than unrelated pairs, but greater activity than identical pairs, mirroring the pattern of behavioral facilitation as measured by word reading times. These findings provide strong support for the involvement of these areas in the automatic processing of object meaning. In addition, words referring to animate objects produced greater activity in the lateral region of the fusiform gyri, right superior temporal sulcus, & medial region of the occipital lobe relative to manmade, manipulable objects, whereas words referring to manmade, manipulable objects produced greater activity in the left ventral premotor, left anterior cingulate, & bilateral parietal cortices relative to animate objects. These findings are consistent with the dissociation between these areas based on sensory- & motor-related object properties, providing further evidence that conceptual object knowledge is housed, in part, in the same neural systems that subserve perception & action. 3 Tables, 3 Figures, 1 Appendix, 98 References. Adapted from the source document JF - Journal of Cognitive Neuroscience AU - Wheatley, Thalia AU - Weisberg, Jill AU - Beauchamp, Michael S AU - Martin, Alex AD - Laboratory Brain & Cognition, National Instit Mental Health, National Instits Health, Bethesda MD wheatley@nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1871 EP - 1885 VL - 17 IS - 12 SN - 0898-929X, 0898-929X KW - Animacy and Inanimacy (03100) KW - Cerebral Dominance (11500) KW - Priming (67670) KW - Meaning (52200) KW - Semantic Categories (76580) KW - Semantic Processing (76760) KW - Neuroimaging Techniques (57245) KW - Reading Rate (71250) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85632733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cognitive+Neuroscience&rft.atitle=Automatic+Priming+of+Semantically+Related+Words+Reduces+Activity+in+the+Fusiform+Gyrus&rft.au=Wheatley%2C+Thalia%3BWeisberg%2C+Jill%3BBeauchamp%2C+Michael+S%3BMartin%2C+Alex&rft.aulast=Wheatley&rft.aufirst=Thalia&rft.date=2005-12-01&rft.volume=17&rft.issue=12&rft.spage=1871&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cognitive+Neuroscience&rft.issn=0898929X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2006-09-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCONEO N1 - SubjectsTermNotLitGenreText - Neuroimaging Techniques (57245); Priming (67670); Semantic Processing (76760); Semantic Categories (76580); Cerebral Dominance (11500); Meaning (52200); Reading Rate (71250); Animacy and Inanimacy (03100) ER - TY - JOUR T1 - Validity of a modified Parkinson's disease screening questionnaire in India: effects of literacy of participants and medical training of screeners and implications for screening efforts in developing countries. AN - 85396222; pmid-16078206 AB - The prevalence of Parkinson's disease (PD) is low among Indians, except in the Parsis. Data for Indians come from studies using different screening tools and criteria to detect PD. An epidemiological study in India, which has nearly a billion people, more than 18 spoken languages, and varying levels of literacy, requires development and validation of a screening tool for PD. The objectives of this study are to (1) validate a modified version of a widely used screening questionnaire for PD to suit the needs of the Indian population; (2) compare the use of a nonmedical assistant (NMA) with the use of a medical person during screening; and (3) compare the effect of literacy of participants on the validity of the screening tool. The validity of the questionnaire was tested on 125 participants from a home for the elderly. NMAs of similar background and medical personnel administered the modified screening questionnaire. A movement disorder neurologist blind to the responses on the questionnaire, examined participants independently and diagnosed if participants had PD. The questionnaire was validated in the movement disorders clinic, on known PD patients and their family members without PD. In the movement disorders clinic, sensitivity and specificity of the questionnaire were 100% and 89%, respectively. Fifty-seven participants were included for analysis. The questionnaire had a higher sensitivity when NMAs (75%) rather than the medical personnel (61%) administered it, and its specificity was higher with the medical personnel (61%) than with NMAs (55% and 25%). The questionnaire had a higher specificity in literates than illiterates, whereas sensitivity varied considerably. The modified questionnaire translated in a local Indian language had reasonable sensitivity and can be used to screen individuals for PD in epidemiological studies in India. This questionnaire can be administered by NMAs to screen PD and this strategy would reduce manpower costs. Literacy may influence epidemiological estimates when screening PD. JF - Movement disorders : official journal of the Movement Disorder Society AU - Sarangmath, Nagaraja AU - Rattihalli, Rohini AU - Ragothaman, Mona AU - Gopalkrishna, Gururaj AU - Doddaballapur, Subbakrishna AU - Louis, Elan D AU - Muthane, Uday B AD - Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India. Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1550 EP - 1556 VL - 20 IS - 12 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Aged, 80 and over KW - *Developing Countries: statistics & numerical data KW - *Educational Status KW - Female KW - Humans KW - India: epidemiology KW - India: ethnology KW - Interviews as Topic: methods KW - Male KW - *Mass Screening KW - Movement Disorders: diagnosis KW - *Parkinson Disease: diagnosis KW - Parkinson Disease: epidemiology KW - *Professional Role KW - *Questionnaires KW - Reproducibility of Results KW - Sensitivity and Specificity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85396222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Validity+of+a+modified+Parkinson%27s+disease+screening+questionnaire+in+India%3A+effects+of+literacy+of+participants+and+medical+training+of+screeners+and+implications+for+screening+efforts+in+developing+countries.&rft.au=Sarangmath%2C+Nagaraja%3BRattihalli%2C+Rohini%3BRagothaman%2C+Mona%3BGopalkrishna%2C+Gururaj%3BDoddaballapur%2C+Subbakrishna%3BLouis%2C+Elan+D%3BMuthane%2C+Uday+B&rft.aulast=Sarangmath&rft.aufirst=Nagaraja&rft.date=2005-12-01&rft.volume=20&rft.issue=12&rft.spage=1550&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Neural correlates of script event knowledge: a neuropsychological study following prefrontal injury. AN - 85395373; pmid-16350660 AB - Scripts sequentially link information about daily activities and event knowledge. Patients have difficulty sequencing script events following lesions of the prefrontal cortex while showing intact access to selective aspects of script knowledge. It has been suggested that the sequencing impairment is due to a deficit in an inhibitory gating mechanisms that usually enables selection of an item from competing alternatives. If this is the case, then an inhibitory task should reveal script processing impairments on a script categorization task that is not normally associated with poor performance following prefrontal damage. To test this hypothesis, we administered a simple untimed classification task and a modified Go/NoGo task in which subjects classified events from social and non-social activities (e.g., read the menu, order the food) and related semantic items (e.g., menu, order) in terms of whether they belonged to a target activity. Participants were patients with lesions of the prefrontal cortex and matched controls. The results showed that damage to the right orbitofrontal cortex was associated with social item classification errors in the simple untimed classification task. In addition, the damage to the right prefrontal cortex was associated with increased response times to respond correctly to Go trials in the modified Go/NoGo task. The data demonstrate that damage to the right orbitofrontal cortex results in impairment in the accessibility of script and semantic representations of social activities. This impairment is exacerbated by an inefficient inhibitory gating mechanism. JF - Cortex; a journal devoted to the study of the nervous system and behavior AU - Wood, Jacqueline N AU - Tierney, Michael AU - Bidwell, Laura A AU - Grafman, Jordan AD - Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1440, USA. Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 796 EP - 804 VL - 41 IS - 6 SN - 0010-9452, 0010-9452 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - Female KW - *Functional Laterality: physiology KW - Humans KW - Magnetic Resonance Imaging KW - Male KW - *Mental Processes: physiology KW - Middle Aged KW - *Neuropsychological Tests KW - *Prefrontal Cortex: pathology KW - Prefrontal Cortex: radiography KW - Psychomotor Performance: physiology KW - Reaction Time: physiology KW - Social Behavior KW - Stroke: pathology KW - *Stroke: psychology KW - Stroke: radiography KW - Tomography, X-Ray Computed UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85395373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cortex%3B+a+journal+devoted+to+the+study+of+the+nervous+system+and+behavior&rft.atitle=Neural+correlates+of+script+event+knowledge%3A+a+neuropsychological+study+following+prefrontal+injury.&rft.au=Wood%2C+Jacqueline+N%3BTierney%2C+Michael%3BBidwell%2C+Laura+A%3BGrafman%2C+Jordan&rft.aulast=Wood&rft.aufirst=Jacqueline&rft.date=2005-12-01&rft.volume=41&rft.issue=6&rft.spage=796&rft.isbn=&rft.btitle=&rft.title=Cortex%3B+a+journal+devoted+to+the+study+of+the+nervous+system+and+behavior&rft.issn=00109452&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Taiwanese cases of SCA2 are derived from a single founder. AN - 85391554; pmid-16078202 AB - We have assessed the haplotypes at the ATXN2 locus in Taiwanese controls and in individuals with SCA2 ataxia with both ataxic and parkinsonian features. Our intention was to determine whether a different ataxin 2 haplotypes predisposed to the two phenotypes. In fact, our analysis showed that all SCA2 mutations carriers had the same ataxin 2 haplotype: haplotype B, which accounts for only 15% of control haplotypes, implying that there is a common founder for all Taiwanese SCA2 patients. JF - Movement disorders : official journal of the Movement Disorder Society AU - Momeni, Parastoo AU - Lu, Chin-Song AU - Chou, Yah-Huei Wu AU - Chang, Hsiu-Chen AU - Chen, Rou-Shayn AU - Chen, Chiung-Chu AU - Hsu, Jin-Tian AU - Singleton, Andrew AU - Hardy, John AD - Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20952, USA. momeni@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1633 EP - 1636 VL - 20 IS - 12 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - *Ataxia: genetics KW - DNA Mutational Analysis KW - Female KW - Gene Frequency KW - Genetic Predisposition to Disease KW - Haplotypes KW - Humans KW - Male KW - Middle Aged KW - *Nerve Tissue Proteins: genetics KW - Parkinson Disease: genetics KW - *Polymorphism, Single Nucleotide: genetics KW - Taiwan: ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85391554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Taiwanese+cases+of+SCA2+are+derived+from+a+single+founder.&rft.au=Momeni%2C+Parastoo%3BLu%2C+Chin-Song%3BChou%2C+Yah-Huei+Wu%3BChang%2C+Hsiu-Chen%3BChen%2C+Rou-Shayn%3BChen%2C+Chiung-Chu%3BHsu%2C+Jin-Tian%3BSingleton%2C+Andrew%3BHardy%2C+John&rft.aulast=Momeni&rft.aufirst=Parastoo&rft.date=2005-12-01&rft.volume=20&rft.issue=12&rft.spage=1633&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Normal tissue radiosensitivity: prediction on deterministic or stochastic basis? AN - 70180125; 17102816 AB - For the same standardized physical radiation dose there is considerable variation, among different patients, of the magnitude of early and late normal tissue reactions. Technical and clinical factors account for about one third only of these variations. Genetic or epigenetic differences between patients account for the greater proportion of interpatient radiosensitivity differences. Attempts have been made to correlate differences in the tissue radiosensitivity with the in vitro radiosensitivity of fibroblasts or lymphocytes as well as with other biological cellular processes related to cell death (mainly DNA repair and chromosomal aberrations). Apart from some genetic diseases such as ataxia telangiectasia, there were positive results in some studies that could not be reproduced in others. It is now realized that for normal tissue radiation-induced morbidity (a) cell kill is not the only factor, (b) interaction with a large number of gene products, such as IL-2, IL-6, TGF-beta, is involved, and (c) radiosensitivity differences can reflect genetic differences. Polymorphism in a wide range of genes can now be demonstrated and analyzed as a source of variations in the radiation response. cDNA microarray procedures can also allow simultaneous measurement, in the same sample, of thousands of genes and thus avoiding basing the investigation on a restricted number of genes. Preliminary results could show retrospectively a correlation between late normal tissue reactions and expression of certain genes. Using cDNA microarray before radiotherapy to predict the occurrence of serious late reactions is still under consideration. Theoretically, an efficient predictor procedure may serve in (a) detection of hypersensitive patients before submitting them to highly toxic radiotherapy regimes such as whole body irradiation, (b) detection of hypersensitive patients in clinical situations where radiotherapy can be effectively replaced by other modalities, and (c) selection of patients for elaborate radiotherapy techniques involving dose escalation to high levels. JF - Journal of the Egyptian National Cancer Institute AU - Awwad, Hassan K AD - The Department of Radiotherapy, National Cancer Institute, Cairo University. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 221 EP - 230 VL - 17 IS - 4 SN - 1110-0362, 1110-0362 KW - Index Medicus KW - Polymorphism, Genetic KW - Dose Fractionation KW - Humans KW - Dose-Response Relationship, Radiation KW - Radiation Tolerance -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70180125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Diminished+Lipoxin+Biosynthesis+in+Severe+Asthma&rft.au=Levy%2C+Bruce+D%3BBonnans%2C+Caroline%3BSilverman%2C+Eric+S%3BPalmer%2C+Lyle+J%3Bet+al&rft.aulast=Levy&rft.aufirst=Bruce&rft.date=2005-10-01&rft.volume=172&rft.issue=7&rft.spage=824&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-06 N1 - Date created - 2006-11-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Abatement by naringenin of doxorubicin-induced cardiac toxicity in rats. AN - 70178993; 17102822 AB - Doxorubicin is one of the most active cytotoxic agents in current use. It has proven efficacy in various malignancies either alone or combined with other cytocidal agents. The clinical usefulness of the anthracycline drug has been precluded by cardiac toxicity. Many therapeutic interventions have been attempted to improve the therapeutic benefits of the drug. Few, however, have been efficacious in this setting. We have addressed in the current study the possible protective effects of naringenin, a flavonoid known to have anti-oxidant properties, on doxorubicin-induced cardiac toxicity in male Swiss albino rats. Forty male Swiss albino rats were used in this study. Naringenin (25 mg/kg body weight) was administered daily by gavage for 7 consecutive days before a cumulative single dose of doxorubicin (15 mg/kg body weight, ip). Doxorubicin induced marked biochemical alterations characteristic of cardiac toxicity including, elevated activities of serum total lactate dehydrogenase (LDH) and creatine phosphokinase (CPK), enhanced lipid peroxidation measured as malondialdehyde (MDA). The anthracycline drug has also reduced the cardiac enzymatic activities of superoxide dismutase (SOD), glutathione-S-transferase (GST) and catalase (CAT). Besides, it reduced significantly the reduced glutathione (GSH) level, but it increased the total NO content in heart tissue. Prior administration of naringenin ahead of doxorubicin challenge ameliorated all these biochemical markers. Taken together, one could conclude that naringenin has a protective role in the abatement of doxorubicin-induced cardiac toxicity that resides, at least in part, on its anti-radical effects and regulatory role on NO production. JF - Journal of the Egyptian National Cancer Institute AU - Arafa, Hossam M AU - Abd-Ellah, Mohamed F AU - Hafez, Hafez F AD - The Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, National Cancer Institute, Cairo University. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 291 EP - 300 VL - 17 IS - 4 SN - 1110-0362, 1110-0362 KW - Antibiotics, Antineoplastic KW - 0 KW - Antioxidants KW - Flavanones KW - Nitric Oxide KW - 31C4KY9ESH KW - Doxorubicin KW - 80168379AG KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Catalase KW - EC 1.11.1.6 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Creatine Kinase KW - EC 2.7.3.2 KW - naringenin KW - HN5425SBF2 KW - Index Medicus KW - Animals KW - Creatine Kinase -- drug effects KW - L-Lactate Dehydrogenase -- drug effects KW - Glutathione Transferase -- metabolism KW - Lipid Peroxidation -- drug effects KW - Superoxide Dismutase -- metabolism KW - Nitric Oxide -- metabolism KW - Superoxide Dismutase -- drug effects KW - Rats KW - Catalase -- metabolism KW - Creatine Kinase -- blood KW - L-Lactate Dehydrogenase -- blood KW - Catalase -- drug effects KW - Glutathione Transferase -- drug effects KW - Male KW - Doxorubicin -- adverse effects KW - Flavanones -- therapeutic use KW - Heart Diseases -- chemically induced KW - Antioxidants -- therapeutic use KW - Heart Diseases -- prevention & control KW - Antibiotics, Antineoplastic -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70178993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Egyptian+National+Cancer+Institute&rft.atitle=Abatement+by+naringenin+of+doxorubicin-induced+cardiac+toxicity+in+rats.&rft.au=Arafa%2C+Hossam+M%3BAbd-Ellah%2C+Mohamed+F%3BHafez%2C+Hafez+F&rft.aulast=Arafa&rft.aufirst=Hossam&rft.date=2005-12-01&rft.volume=17&rft.issue=4&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Egyptian+National+Cancer+Institute&rft.issn=11100362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-06 N1 - Date created - 2006-11-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of neurotoxic potential by use of in vitro systems. AN - 70170689; 16863434 AB - In vitro systems have been proposed, but not yet demonstrated, as a method to assess the neurotoxicity of compounds in an efficient and rapid manner. Although such tests are desired both for pharmaceuticals and environmental agents, such a battery has yet to be developed that is based on known processes of nervous system dysfunction. In this review article, characteristics and potential limitations associated with in vitro methods are discussed. Many of these features have been identified from a larger body of work examining the neurotoxicity of environmental agents and the mechanisms underlying activity of known neurotoxicants. These issues include relevant drug concentrations, factors that limit or alter drug accessibility to the nervous system, and the need for assays to reflect biologically meaningful end points. This commentary briefly surveys in vitro systems of increasing biological complexity currently available for toxicity testing, from single cell types to systems that preserve some aspects of tissue structure and function. A small number of studies to evaluate drugs for cytotoxicity and biological responses in vitro are presented as representative of the current state of the field and to provide a reference and direction for additional development of methods to assess a compound's potential for neurotoxicity. JF - Expert opinion on drug metabolism & toxicology AU - Harry, Gaylia Jean AU - Tiffany-Castiglioni, Evelyn AD - National Institutes of Health, Laboratory of Neurobiology, National Institute of Environmental Health Sciences, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. harry@niehs.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 701 EP - 713 VL - 1 IS - 4 SN - 1742-5255, 1742-5255 KW - Index Medicus KW - Animals KW - Animal Testing Alternatives KW - Cell Survival -- drug effects KW - Neurites -- drug effects KW - Humans KW - Learning -- drug effects KW - Neurites -- physiology KW - Organ Culture Techniques KW - Cell Line KW - Blood-Brain Barrier KW - Nervous System -- drug effects KW - Toxicity Tests -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70170689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.atitle=Evaluation+of+neurotoxic+potential+by+use+of+in+vitro+systems.&rft.au=Harry%2C+Gaylia+Jean%3BTiffany-Castiglioni%2C+Evelyn&rft.aulast=Harry&rft.aufirst=Gaylia&rft.date=2005-12-01&rft.volume=1&rft.issue=4&rft.spage=701&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.issn=17425255&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-16 N1 - Date created - 2006-07-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of loss of heterozygosity on chromosomes 8 and 9 in the development and progression of cancer bladder. AN - 70168569; 17102820 AB - Loss of heterozygosity (LOH) in tumor samples is believed to be a marker for the absence of a functional tumor suppressor gene. Non-random chromosome deletion and LOH at specific chromosomal regions are identified in a number of common human cancers including carcinoma of the bladder, which is considered the most predominant cancer in Egypt due to the prevalence of schistosomiasis. The main objective of the present study is to clarify the role of chromosomes 8 and 9 in the establishment and/or progression of schistosomiasis-related bladder cancer through detection of LOH of 8 microsatellite markers on both chromosomes. It also aims to compare the LOH pattern of the tested markers between schistosomiasis- associated and non schistosomiasis-associated bladder cancer. To achieve this purpose, DNA was extracted from the tumor specimens and the corresponding peripheral blood samples of 42 primary bladder cancer patients (schistosomal and non schistosomal). Twenty nine of these were diagnosed as squamous cell type (SCC), 11 were transitional (TCC), and 2 were adenocarcinoma (with different stages and grades). LOH at chromosomes 8 and 9 was evaluated for 8 highly polymorphic microsatellite markers distributed at different regions of both chromosomes using the dinucleotide repeat-PCR technique. The overall percentage of LOH in chromosome 8 was 74% in at least one marker. The highest incidence of LOH was recorded for D8S84 (41%) followed by 37% for D8S87, 29% for D8S85, and 25% for D8S88. Deletions at chromosome 8 were shown to be associated with high grade of the tumor and LOH at D8S85 was associated with metastatic lymph nodes. The overall percentage of LOH in chromosome 9 was 54% and its highest incidence was for D9S126 (36%), followed by 26%, 21%, 19% for D9S166, D9S128 and D9S180, respectively. Fifty nine percent (59%) of the cases with LOH at 9q were diagnosed as squamous cell type (SCC), whereas 9% only were transitional cell type (TCC). No significant association was recorded between the presence of schistosomiasis and LOH detected in all markers used in this study. Our data indicate that more than one tumor suppressor gene on chromosomes 8 and 9 are involved in high grades of bladder carcinogenesis, one at 8p12 and another at 8q21.1 regions. Also, a region at 8q23-quarter may harbor tumor suppressor gene that involved in metastasis of bladder cancer. Our study also revealed that 9p21 (p16INK4) region is involved in both types of the tumor (SCC & TCC). PTCH located at 9q22.3, as well as the TSC gene at 9q34 are involved in squamous cell carcinoma rather than transitional carcinoma. Region 9q12-13 is considered to be a critical region of urothelial tumor suppressor genes. Finally, the present study shows no line of demarcation between schistosomiasis-associate and non schistosomiasis-associated bladder cancer in terms of LOH of the tested microsatellite markers on chromosome 8 and 9. This suggests that data obtained from schistosoma-associated bladder cancer can be extrapolated to bladder cancer induced by a schistosomiasis independent mechanism. JF - Journal of the Egyptian National Cancer Institute AU - Abdel Wahab, Abdel Hady A AU - Abo-Zeid, Hamdy I AU - El-Husseini, Motawa I AU - Ismail, Mohsein AU - El-Khor, Akmal M AD - The Department of Biochemistry & Molecular Biology Unit, NCI, Cairo University. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 260 EP - 269 VL - 17 IS - 4 SN - 1110-0362, 1110-0362 KW - DNA, Neoplasm KW - 0 KW - Index Medicus KW - Polymerase Chain Reaction KW - Microsatellite Repeats KW - Humans KW - Disease Progression KW - DNA, Neoplasm -- analysis KW - Loss of Heterozygosity KW - Schistosomiasis haematobia -- complications KW - Urinary Bladder Neoplasms -- genetics KW - Chromosomes, Human, Pair 8 -- genetics KW - Urinary Bladder Neoplasms -- microbiology KW - Chromosomes, Human, Pair 9 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70168569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Egyptian+National+Cancer+Institute&rft.atitle=Role+of+loss+of+heterozygosity+on+chromosomes+8+and+9+in+the+development+and+progression+of+cancer+bladder.&rft.au=Abdel+Wahab%2C+Abdel+Hady+A%3BAbo-Zeid%2C+Hamdy+I%3BEl-Husseini%2C+Motawa+I%3BIsmail%2C+Mohsein%3BEl-Khor%2C+Akmal+M&rft.aulast=Abdel+Wahab&rft.aufirst=Abdel+Hady&rft.date=2005-12-01&rft.volume=17&rft.issue=4&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Egyptian+National+Cancer+Institute&rft.issn=11100362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-06 N1 - Date created - 2006-11-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Weight of evidence: a review of concept and methods. AN - 70146526; 16506981 AB - "Weight of evidence" (WOE) is a common term in the published scientific and policy-making literature, most often seen in the context of risk assessment (RA). Its definition, however, is unclear. A systematic review of the scientific literature was undertaken to characterize the concept. For the years 1994 through 2004, PubMed was searched for publications in which "weight of evidence" appeared in the abstract and/or title. Of the 276 papers that met these criteria, 92 were selected for review: 71 papers published in 2003 and 2004 (WOE appeared in abstract/title) and 21 from 1994 through 2002 (WOE appeared in title). WOE has three characteristic uses in this literature: (1) metaphorical, where WOE refers to a collection of studies or to an unspecified methodological approach; (2) methodological, where WOE points to established interpretative methodologies (e.g., systematic narrative review, meta-analysis, causal criteria, and/or quality criteria for toxicological studies) or where WOE means that "all" rather than some subset of the evidence is examined, or rarely, where WOE points to methods using quantitative weights for evidence; and (3) theoretical, where WOE serves as a label for a conceptual framework. Several problems are identified: the frequent lack of definition of the term "weight of evidence," multiple uses of the term and a lack of consensus about its meaning, and the many different kinds of weights, both qualitative and quantitative, which can be used in RA. A practical recommendation emerges: the WOE concept and its associated methods should be fully described when used. A research agenda should examine the advantages of quantitative versus qualitative weighting schemes, how best to improve existing methods, and how best to combine those methods (e.g., epidemiology's causal criteria with toxicology's quality criteria). JF - Risk analysis : an official publication of the Society for Risk Analysis AU - Weed, Douglas L AD - National Cancer Institute, Rockville, MD 20852, USA. dw102i@nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1545 EP - 1557 VL - 25 IS - 6 SN - 0272-4332, 0272-4332 KW - Index Medicus KW - Public Health KW - Epidemiology KW - Humans KW - Meta-Analysis as Topic KW - Toxicology KW - Risk Assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70146526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+education+and+prevention&rft.atitle=Epidemiology+of+HIV%2FAIDS+among+Asians+and+Pacific+islanders+in+the+United+States&rft.au=Zaidi%2C+Irum+F%3BCrepaz%2C+Nicole%3BSong%2C+Ruiguang%3BWan%2C+Choi+K%3BLin%2C+Lillian+S%3BHu%2C+Dale+J%3BSy%2C+Francisco+S&rft.aulast=Zaidi&rft.aufirst=Irum&rft.date=2005-10-01&rft.volume=17&rft.issue=5&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=AIDS+education+and+prevention&rft.issn=08999546&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-20 N1 - Date created - 2006-03-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Risk Anal. 2006 Jun;26(3):573-5; author reply 577 [16834614] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A slow disengagement from platinum-based chemotherapy for patients with advanced non-small cell lung cancer. AN - 70112277; 16434876 JF - Cancer biology & therapy AU - Ballas, Marc S AU - Dennis, Phillip A AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20889, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1316 EP - 1317 VL - 4 IS - 12 SN - 1538-4047, 1538-4047 KW - irinotecan KW - 0H43101T0J KW - Platinum KW - 49DFR088MY KW - Paclitaxel KW - P88XT4IS4D KW - Camptothecin KW - XT3Z54Z28A KW - Index Medicus KW - Paclitaxel -- administration & dosage KW - Drug Administration Schedule KW - Diarrhea -- chemically induced KW - Paclitaxel -- adverse effects KW - Survival Rate KW - Humans KW - Camptothecin -- analogs & derivatives KW - Neutropenia -- chemically induced KW - Maximum Tolerated Dose KW - Camptothecin -- adverse effects KW - Time Factors KW - Camptothecin -- administration & dosage KW - Carcinoma, Non-Small-Cell Lung -- mortality KW - Platinum -- therapeutic use KW - Lung Neoplasms -- drug therapy KW - Lung Neoplasms -- mortality KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Lung Neoplasms -- pathology KW - Carcinoma, Non-Small-Cell Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70112277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+biology+%26+therapy&rft.atitle=A+slow+disengagement+from+platinum-based+chemotherapy+for+patients+with+advanced+non-small+cell+lung+cancer.&rft.au=Ballas%2C+Marc+S%3BDennis%2C+Phillip+A&rft.aulast=Ballas&rft.aufirst=Marc&rft.date=2005-12-01&rft.volume=4&rft.issue=12&rft.spage=1316&rft.isbn=&rft.btitle=&rft.title=Cancer+biology+%26+therapy&rft.issn=15384047&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-22 N1 - Date created - 2006-02-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Cancer Biol Ther. 2005 Dec;4(12):1311-5 [16258263] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Imatinib synergizes with donor lymphocyte infusions to achieve rapid molecular remission of CML relapsing after allogeneic stem cell transplantation. AN - 69062281; 16205732 AB - Donor lymphocyte infusions (DLI) have been the mainstay of treatment for chronic myeloid leukemia (CML) relapsing after allogeneic stem cell transplantation (allo-SCT). Imatinib mesylate (IM) is also effective in these patients. However, advanced phase relapse (APRel) responds poorly with either treatment. To test the possibility that combinations of DLI and IM might be more effective, 37 patients with CML relapsing after allo-SCT between August 1994 and May 2004 were studied. Ten had molecular relapse (MRel), 14 hematological relapse (HRel) and 13 APRel. Thirteen received DLI, 9 IM and 11 DLI+IM. Four patients received DLI+IM but not concurrently. Thirty (81%) patients responded (actuarial survival and current leukemia-free survival of 80.6 +/- 6.7% and 69.1 +/- 7.7%). Of 30 patients, 26 are in molecular remission (MR), median follow-up of 1,226 days (range 249-3257) since relapse. Ten of 11 patients (including four with APRel) treated with DLI+IM achieved MR in 3 months and all are alive in MR. In contrast, only two of 22 treated with either modality (1/13 DLI and 1/9 IM) achieved MR at 3 months, 15 are alive, 11 in MR. Four patients receiving nonconcurrent DLI+IM are also alive in MR. In conclusion, DLI appears to synergize with IM to induce rapid and durable MR. JF - Bone marrow transplantation AU - Savani, B N AU - Montero, A AU - Kurlander, R AU - Childs, R AU - Hensel, N AU - Barrett, A J AD - Stem Cell Allogeneic Transplantation Section, Hematology Branch, NHLBI, National Institutes of Health, Building 10, Hatfield CRC, 10 Center Drive MSC 1202, Bethesda, MD 20892-1202, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1009 EP - 1015 VL - 36 IS - 11 SN - 0268-3369, 0268-3369 KW - Benzamides KW - 0 KW - Piperazines KW - Pyrimidines KW - Imatinib Mesylate KW - 8A1O1M485B KW - Index Medicus KW - Humans KW - Adult KW - Retrospective Studies KW - Aged KW - Remission Induction -- methods KW - Middle Aged KW - Transplantation, Homologous KW - Drug Synergism KW - Adolescent KW - Recurrence KW - Male KW - Female KW - Survival Analysis KW - Lymphocyte Transfusion KW - Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- mortality KW - Hematopoietic Stem Cell Transplantation KW - Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- therapy KW - Pyrimidines -- administration & dosage KW - Piperazines -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69062281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bone+marrow+transplantation&rft.atitle=Imatinib+synergizes+with+donor+lymphocyte+infusions+to+achieve+rapid+molecular+remission+of+CML+relapsing+after+allogeneic+stem+cell+transplantation.&rft.au=Savani%2C+B+N%3BMontero%2C+A%3BKurlander%2C+R%3BChilds%2C+R%3BHensel%2C+N%3BBarrett%2C+A+J&rft.aulast=Savani&rft.aufirst=B&rft.date=2005-12-01&rft.volume=36&rft.issue=11&rft.spage=1009&rft.isbn=&rft.btitle=&rft.title=Bone+marrow+transplantation&rft.issn=02683369&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-03 N1 - Date created - 2006-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of fluorenhymustine as a rationally designed novel anticancer agent. AN - 69061070; 16404347 AB - To develop a rationally designed new nitrogen mustard namely Fluorenhymustine (compound 2), where N,N'-bis(2chloro-ethyl)amino group, the established anticancer functionality, is attached to the 2-ethyl fluorenone hydantoin moiety. Starting from fluorenone hydantoin, a 3-step synthetic procedure was followed to obtain the title compound. 4-(4-Nitrobenzyl)pyridine was used to assess its chemical alkylating activity. Murine tumors (Ehrlich ascites carcinoma (EAC) and Sarcoma-180 (S-180)) were used to assess its in vivo activity. Its cytotoxicity was determined in vitro in MCF-7 human breast tumor cell line, toxicity - in vivo in normal and EAC bearing mice. 3H-Thymidine and 3H-Uridine were employed to study its inhibitory effect on DNA and RNA synthesis respectively in S-180 tumor cells in vitro. Alkylating activity of fluorenmustine exceeded that of N-di(2-chloroethyl)amine used as a standard alkylating compound. It has displayed an excellent and reproducible antitumor activity in vivo against EAC and S-180 comparable to that of 5-fluorouracil judging by the increase in median survival times of treated animals. It also significantly increased the life span of mice bearing advanced tumors for 6 days before the drug challenge. However in vitro screening in MCF-7 did not reveal any significant cytotoxicity. The compound did not adversely affect hematopoiesis at its optimum dose. Drug-induced hepatotoxicity and nephrotoxicity were also not detected. It inhibited the synthesis of DNA and RNA in S-180 tumor cells at 8 microM concentration. Results indicated promising chemotherapeutic potential of Fluorenhymustine. JF - Experimental oncology AU - Samanta, S AU - Pain, A AU - Ghosh, M AU - Dutta, S AU - Sanyal, U AD - Department of Anticancer Drug Development, Chittaranjan National Cancer Institute, Calcutta 700026, India. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 279 EP - 285 VL - 27 IS - 4 SN - 1812-9269, 1812-9269 KW - Antineoplastic Agents, Alkylating KW - 0 KW - Nitrogen Mustard Compounds KW - fluorenhymustine KW - Index Medicus KW - Drug Screening Assays, Antitumor KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Mice KW - Cell Line, Tumor KW - Drug Evaluation, Preclinical KW - Antineoplastic Agents, Alkylating -- chemical synthesis KW - Antineoplastic Agents, Alkylating -- pharmacology KW - Nitrogen Mustard Compounds -- chemical synthesis KW - Neoplasms, Experimental -- drug therapy KW - Nitrogen Mustard Compounds -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69061070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+oncology&rft.atitle=Evaluation+of+fluorenhymustine+as+a+rationally+designed+novel+anticancer+agent.&rft.au=Samanta%2C+S%3BPain%2C+A%3BGhosh%2C+M%3BDutta%2C+S%3BSanyal%2C+U&rft.aulast=Samanta&rft.aufirst=S&rft.date=2005-12-01&rft.volume=27&rft.issue=4&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Experimental+oncology&rft.issn=18129269&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-02 N1 - Date created - 2006-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - [Social aspects and cancer: information dedicated to cancer patients and relatives]. TT - Démarches sociales et cancer Information à l'usage des personnes malades et de leurs proches. AN - 69054045; 16396756 AB - In response to the evolution of the information-seeking behaviour of patients and concerns from health professionals regarding cancer patient information, the French National Federation of Comprehensive Cancer Centres (FNCLCC) introduced, in 1998, an information and education program dedicated to patients and relatives, the SOR SAVOIR PATIENT program (SSP). The methodology of this program adheres to established quality criteria regarding the elaboration of patient information. Cancer patient information, developed in this program, is based on clinical practice guidelines produced by the FNCLCC and the twenty French regional cancer centres, the National League against Cancer, The National Cancer Institute, the French Hospital Federation, the National Oncology Federation of Regional and University Hospitals, the French Oncology Federation of General Hospitals, many learned societies, as well as an active participation of patients, former patients and caregivers. The information and dialogue handbook SOR SAVOIR PATIENT Social aspects & cancer partly published in this edition of the Bulletin du cancer, provides specific information regarding patient social rights and benefits extracted from the texts of laws currently in force in France. It also relies on the handbook A "Prévoir Demain, La réinsertion des patients traités pour cancers A", realised in partnership with the FNCLCC, the Coloplast foundation for quality of life and the National League against Cancer. This document is available from the FNCLCC (101, rue de Tolbiac, 75013 Paris, Tel. (0033) 1 44 23 04 68, www.fnclcc.fr). The handbook A "Social aspects & cancer A" was worked out and published in 2004. Information may change with new legal regulations. It is therefore strongly advised to refer to the texts of laws in force to check for possible amendments. This article aims to help patients and relatives to be better aware of their social rights, to locate the different social and administrative services concerned (CAF, Cotorep, etc.) and to turn to the right person and the appropriate agency in the event of social difficulties during and after the disease. This document is designed to offer health professionals a validated information digest of all resources available in order to better communicate with the patient on social aspects of cancer. JF - Bulletin du cancer AU - FNCLCC AU - French regional cancer centres AU - National League against Cancer AU - National Cancer Institute AU - French Hospital Federation AU - National Oncology Federation of Regional and University Hospitals AU - French Oncology Federation of General Hospitals AD - FNCLCC ; French regional cancer centres ; National League against Cancer ; National Cancer Institute ; French Hospital Federation ; National Oncology Federation of Regional and University Hospitals ; French Oncology Federation of General Hospitals Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1093 EP - 1113 VL - 92 IS - 12 KW - Index Medicus KW - France KW - Humans KW - Program Development KW - Home Care Services -- organization & administration KW - Guidelines as Topic KW - Occupational Diseases -- therapy KW - Patient Education as Topic KW - Family KW - Neoplasms -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69054045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bulletin+du+cancer&rft.atitle=%5BSocial+aspects+and+cancer%3A+information+dedicated+to+cancer+patients+and+relatives%5D.&rft.au=FNCLCC%3BFrench+regional+cancer+centres%3BNational+League+against+Cancer%3BNational+Cancer+Institute%3BFrench+Hospital+Federation%3BNational+Oncology+Federation+of+Regional+and+University+Hospitals%3BFrench+Oncology+Federation+of+General+Hospitals&rft.aulast=FNCLCC&rft.aufirst=&rft.date=2005-12-01&rft.volume=92&rft.issue=12&rft.spage=1093&rft.isbn=&rft.btitle=&rft.title=Bulletin+du+cancer&rft.issn=1769-6917&rft_id=info:doi/ LA - fre DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-19 N1 - Date created - 2006-01-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A pilot study to evaluate the vascular endothelial growth factor receptor tyrosine kinase inhibitor AZD2171 and chemotherapy in locally advanced and inflammatory breast cancer. AN - 69047013; 16381631 JF - Clinical breast cancer AU - Denduluri, Neelima AU - Tan, Antoinette R AU - Walshe, Janice AU - Berman, Arlene AU - Yang, Sherry X AU - Chow, Catherine K AU - Swain, Sandra M AD - Breast Cancer Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 460 EP - 463 VL - 6 IS - 5 SN - 1526-8209, 1526-8209 KW - Enzyme Inhibitors KW - 0 KW - Quinazolines KW - Receptors, Vascular Endothelial Growth Factor KW - EC 2.7.10.1 KW - cediranib KW - NQU9IPY4K9 KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Clinical Trials, Phase II as Topic KW - Humans KW - Inflammation -- drug therapy KW - Pilot Projects KW - Female KW - Breast Neoplasms -- drug therapy KW - Enzyme Inhibitors -- adverse effects KW - Receptors, Vascular Endothelial Growth Factor -- antagonists & inhibitors KW - Enzyme Inhibitors -- therapeutic use KW - Quinazolines -- therapeutic use KW - Breast Neoplasms -- etiology KW - Quinazolines -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69047013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+breast+cancer&rft.atitle=A+pilot+study+to+evaluate+the+vascular+endothelial+growth+factor+receptor+tyrosine+kinase+inhibitor+AZD2171+and+chemotherapy+in+locally+advanced+and+inflammatory+breast+cancer.&rft.au=Denduluri%2C+Neelima%3BTan%2C+Antoinette+R%3BWalshe%2C+Janice%3BBerman%2C+Arlene%3BYang%2C+Sherry+X%3BChow%2C+Catherine+K%3BSwain%2C+Sandra+M&rft.aulast=Denduluri&rft.aufirst=Neelima&rft.date=2005-12-01&rft.volume=6&rft.issue=5&rft.spage=460&rft.isbn=&rft.btitle=&rft.title=Clinical+breast+cancer&rft.issn=15268209&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-26 N1 - Date created - 2005-12-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Concepts and clinical trials of dose-dense chemotherapy for breast cancer . AN - 69043758; 16381623 AB - This article will review the strategy of dose-dense administration of chemotherapy for breast cancer. Increased dose density is achieved by reducing the interval between each dose of chemotherapy. The cumulative drug dose remains constant, but the same amount of drug is administered over a shorter period. Mathematical models of tumor growth have provided the basis for the clinical application of dose-dense chemotherapy. The Norton-Simon model suggests that increasing the dose density of chemotherapy will increase efficacy by minimizing the opportunity for regrowth of tumor cells between cycles of chemotherapy. Intergroup trial 9741, coordinated by the Cancer and Leukemia Group B (CALGB), tested the 2 hypotheses that dose-dense and sequential administration of chemotherapy regimens incorporating doxorubicin, cyclophosphamide, and paclitaxel would improve disease-free survival and overall survival. A statistically significant 4-year disease-free survival advantage was detected for the 2 dose-dense regimens compared with the regimens administered every 3 weeks. The mathematical concepts and previous clinical trials of dose density that contributed to the design of CALGB 9741 will be reviewed. The strengths and limitations of CALGB 9741 will then be discussed before the presentation of future directions of research and recommendations for clinical practice today. JF - Clinical breast cancer AU - Orzano, Jennifer A AU - Swain, Sandra M AD - Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Department of Health & Human Services, Bethesda, MD, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 402 EP - 411 VL - 6 IS - 5 SN - 1526-8209, 1526-8209 KW - Taxoids KW - 0 KW - Index Medicus KW - Humans KW - Clinical Trials as Topic KW - Models, Biological KW - Female KW - Mathematics KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- pathology KW - Dose-Response Relationship, Drug KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Taxoids -- toxicity KW - Taxoids -- therapeutic use KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Taxoids -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69043758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Philosophical+transactions+of+the+Royal+Society+of+London.+Series+B%2C+Biological+sciences&rft.atitle=Induction+of+transplantation+tolerance+in+non-human+primate+preclinical+models.&rft.au=Hale%2C+Douglas+A%3BDhanireddy%2C+Kiran%3BBruno%2C+David%3BKirk%2C+Allan+D&rft.aulast=Hale&rft.aufirst=Douglas&rft.date=2005-09-29&rft.volume=360&rft.issue=1461&rft.spage=1723&rft.isbn=&rft.btitle=&rft.title=Philosophical+transactions+of+the+Royal+Society+of+London.+Series+B%2C+Biological+sciences&rft.issn=09628436&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-26 N1 - Date created - 2005-12-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Local distribution and toxicity of prolonged hippocampal infusion of muscimol. AN - 69043209; 16381190 AB - The activity of gamma-aminobutyric acid (GABA), the principal inhibitory neurotransmitter, is reduced in the hippocampus in patients with complex partial seizures from mesial temporal sclerosis. To provide preliminary safety and distribution data on using convection-enhanced delivery of agents to treat complex partial seizures and to test the efficacy and safety of regional selective neuronal suppression, the authors infused muscimol, a GABA-A receptor agonist, directly into the hippocampus of nonhuman primates using an integrated catheter electrode. Ten rhesus monkeys were divided into three groups: 1) use of catheter electrode alone (four monkeys); 2) infusion of escalating concentrations of muscimol followed by vehicle (three monkeys); and 3) infusion of vehicle and subsequent muscimol mixed with muscimol tracer (three monkeys). Infusions were begun 5 days after catheter electrode placement and continued for 5.6 days before switching to the other agent. Head magnetic resonance (MR) images and electroencephalography recordings were obtained before and during the infusions. Brain histological studies and quantitative autoradiography were performed. Neurological function was normal in controls and when muscimol concentrations were 0.125 mM or less, whereas higher concentrations (0.5 and 1 mM) produced reversible apathy and somnolence. Fluid distribution was demonstrated on MR images and muscimol distribution was demonstrated on autoradiographs throughout the hippocampus and adjacent white matter. Targeted modulation of neuronal activity is a reasonable research strategy for the investigation and treatment of medically intractable epilepsy. JF - Journal of neurosurgery AU - Heiss, John D AU - Walbridge, Stuart AU - Morrison, Paul AU - Hampton, Robert R AU - Sato, Susumu AU - Vortmeyer, Alexander AU - Butman, John A AU - O'Malley, James AU - Vidwan, Param AU - Dedrick, Robert L AU - Oldfield, Edward H AD - Surgical Neurology Branch, Electroencephalography Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1414, USA. heissj@ninds.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1035 EP - 1045 VL - 103 IS - 6 SN - 0022-3085, 0022-3085 KW - GABA Agonists KW - 0 KW - Muscimol KW - 2763-96-4 KW - Abridged Index Medicus KW - Index Medicus KW - Osmolar Concentration KW - Magnetic Resonance Imaging KW - Animals KW - Drug Administration Schedule KW - Dose-Response Relationship, Drug KW - Brain -- pathology KW - Electroencephalography KW - Macaca mulatta KW - Drug Delivery Systems -- adverse effects KW - Tissue Distribution KW - Autoradiography KW - Male KW - Female KW - Muscimol -- administration & dosage KW - Hippocampus -- physiology KW - GABA Agonists -- pharmacokinetics KW - GABA Agonists -- administration & dosage KW - Hippocampus -- metabolism KW - Muscimol -- poisoning KW - Muscimol -- pharmacokinetics KW - GABA Agonists -- poisoning KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69043209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurosurgery&rft.atitle=Local+distribution+and+toxicity+of+prolonged+hippocampal+infusion+of+muscimol.&rft.au=Heiss%2C+John+D%3BWalbridge%2C+Stuart%3BMorrison%2C+Paul%3BHampton%2C+Robert+R%3BSato%2C+Susumu%3BVortmeyer%2C+Alexander%3BButman%2C+John+A%3BO%27Malley%2C+James%3BVidwan%2C+Param%3BDedrick%2C+Robert+L%3BOldfield%2C+Edward+H&rft.aulast=Heiss&rft.aufirst=John&rft.date=2005-12-01&rft.volume=103&rft.issue=6&rft.spage=1035&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurosurgery&rft.issn=00223085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-12-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of ramosetron and granisetron for the prevention of acute and delayed emesis in Cisplatin-based chemotherapy: a randomized controlled trial. AN - 69039624; 16319109 AB - A clinical study of ramosetron was carried out to evaluate its efficacy in preventing both acute and delayed emesis in cisplatin-based chemotherapy by using a double-blind method with granisetron as the comparative drug. Cisplatin at a dose of > or =70 mg/m(2) was administered as a single intravenous (i.v.) infusion over 4 h. Patients were randomly assigned to receive either ramosetron (0.3 mg i.v. bolus 30 min before cisplatin on Day 1 and a 0.1 mg tablet in the morning for Days 2 to 5 after completion of chemotherapy; n = 36) or granisetron (3 mg i.v. infusion 30 min before cisplatin on Day 1 and a 1 mg tablet in the morning for Days 2 to 5 after completion of chemotherapy; n = 37). The observation period started with the initiation of chemotherapy (0 h) and continued for 24 h after completion of the chemotherapy for acute emesis, and on Days 2 to 5 for delayed nausea and vomiting. A total of 73 patients were eligible for evaluation, with 36 patients in the ramosetron group and 37 in the granisetron group. The efficacy of both drugs was analyzed in terms of the degree of achievement in each day of treatment. Ramosetron was as effective as granisetron in preventing nausea and vomiting (both acute and delayed emesis). The two drugs had a similar safety profile and adverse events were generally mild and transient. Ramosetron is effective and safe for the control of acute and delayed emesis induced by cisplatin. JF - Japanese journal of clinical oncology AU - Cheirsilpa, Arkom AU - Sinthusake, Tanadej AU - Songsakkaesorn, Apinya AU - Visawaprasit, Somchit AU - Chulaka, Kemachit AU - Changkuingdee, Nunchaporn AD - Division of Medical Oncology, National Cancer Institute, 268/1 Rama 6th Road, Rajthevi, Bangkok 10400, Thailand. silpa@health.moph.go.th Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 695 EP - 699 VL - 35 IS - 12 SN - 0368-2811, 0368-2811 KW - Antiemetics KW - 0 KW - Benzimidazoles KW - ramosetron KW - 7ZRO0SC54Y KW - Cisplatin KW - Q20Q21Q62J KW - Granisetron KW - WZG3J2MCOL KW - Index Medicus KW - Dizziness -- chemically induced KW - Neoplasms -- drug therapy KW - Drug Administration Schedule KW - Double-Blind Method KW - Endpoint Determination KW - Humans KW - Aged KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Headache -- chemically induced KW - Aged, 80 and over KW - Adult KW - Middle Aged KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Male KW - Female KW - Granisetron -- adverse effects KW - Antiemetics -- therapeutic use KW - Granisetron -- therapeutic use KW - Nausea -- prevention & control KW - Benzimidazoles -- adverse effects KW - Vomiting, Anticipatory -- prevention & control KW - Benzimidazoles -- therapeutic use KW - Cisplatin -- adverse effects KW - Antiemetics -- adverse effects KW - Cisplatin -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69039624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Japanese+journal+of+clinical+oncology&rft.atitle=Comparison+of+ramosetron+and+granisetron+for+the+prevention+of+acute+and+delayed+emesis+in+Cisplatin-based+chemotherapy%3A+a+randomized+controlled+trial.&rft.au=Cheirsilpa%2C+Arkom%3BSinthusake%2C+Tanadej%3BSongsakkaesorn%2C+Apinya%3BVisawaprasit%2C+Somchit%3BChulaka%2C+Kemachit%3BChangkuingdee%2C+Nunchaporn&rft.aulast=Cheirsilpa&rft.aufirst=Arkom&rft.date=2005-12-01&rft.volume=35&rft.issue=12&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=Japanese+journal+of+clinical+oncology&rft.issn=03682811&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-03 N1 - Date created - 2005-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reproductive outcomes in men with prenatal exposure to diethylstilbestrol. AN - 68904275; 16359959 AB - To examine prenatal diethylstilbestrol (DES) exposure in relation to male reproductive outcomes. Prospective observational study. Participants were identified through record review, clinical trial participation, or an obstetrics clinic. A total of 1,085 DES-exposed and 1,047 unexposed men. Participants were exposed prenatally to DES through the mother's obstetrics care or clinical trial participation. Infertility; never fathering a pregnancy or live birth; number of pregnancies or live births fathered. We found little evidence that prenatal DES exposure affects the likelihood of never fathering a pregnancy or live birth, or influences the mean number of fathered pregnancies or live births. Our data suggest that DES-exposed men are slightly more likely to experience infertility (relative risk [RR] = 1.3, 95% confidence interval [CI] = 1.0-1.6). The DES dose and gestational timing did not influence infertility or the number of pregnancies or live births fathered, but results were inconsistent for dose effects on the likelihood of never fathering a pregnancy or a live birth. Prenatal DES exposure may be associated with a slightly increased risk of having an infertility experience, but does not increase the likelihood of never fathering a pregnancy or a live birth, or the number of pregnancies or live births fathered. JF - Fertility and sterility AU - Perez, Kimberly M AU - Titus-Ernstoff, Linda AU - Hatch, Elizabeth E AU - Troisi, Rebecca AU - Wactawski-Wende, Jean AU - Palmer, Julie R AU - Noller, Kenneth AU - Hoover, Robert N AU - National Cancer Institute's DES Follow-up Study Group AD - Department of Social and Preventive Medicine, University of Buffalo, State of New York, Buffalo, New York, USA. ; National Cancer Institute's DES Follow-up Study Group Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1649 EP - 1656 VL - 84 IS - 6 KW - Estrogens, Non-Steroidal KW - 0 KW - Diethylstilbestrol KW - 731DCA35BT KW - Index Medicus KW - Prospective Studies KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Interviews as Topic KW - Middle Aged KW - Follow-Up Studies KW - Adolescent KW - Male KW - Female KW - Pregnancy KW - Age Distribution KW - Diethylstilbestrol -- adverse effects KW - Pregnancy Outcome -- epidemiology KW - Prenatal Exposure Delayed Effects -- epidemiology KW - Infertility, Male -- chemically induced KW - Estrogens, Non-Steroidal -- administration & dosage KW - Diethylstilbestrol -- administration & dosage KW - Infertility, Male -- epidemiology KW - Estrogens, Non-Steroidal -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68904275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fertility+and+sterility&rft.atitle=Reproductive+outcomes+in+men+with+prenatal+exposure+to+diethylstilbestrol.&rft.au=Perez%2C+Kimberly+M%3BTitus-Ernstoff%2C+Linda%3BHatch%2C+Elizabeth+E%3BTroisi%2C+Rebecca%3BWactawski-Wende%2C+Jean%3BPalmer%2C+Julie+R%3BNoller%2C+Kenneth%3BHoover%2C+Robert+N%3BNational+Cancer+Institute%27s+DES+Follow-up+Study+Group&rft.aulast=Perez&rft.aufirst=Kimberly&rft.date=2005-12-01&rft.volume=84&rft.issue=6&rft.spage=1649&rft.isbn=&rft.btitle=&rft.title=Fertility+and+sterility&rft.issn=1556-5653&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-08 N1 - Date created - 2005-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Science and society: the Long Island Breast Cancer Study Project. AN - 68885594; 16341086 AB - In the early 1990s, breast cancer advocates petitioned the United States Congress to investigate the high rates of breast cancer on Long Island in the state of New York. The resulting law led to the Long Island Breast Cancer Study Project (LIBCSP)--more than ten research projects designed to study the possible causes of this increased incidence of cancer. This project reported that there was no evidence that environmental exposures were responsible. Controversial from its start, the LIBCSP has had an important role in efforts to understand the reasons for the high rates of breast cancer in some regions of the United States. JF - Nature reviews. Cancer AU - Winn, Deborah M AD - Clinical and Genetic Epidemiology Research Branch, Division of Cancer Control and Population Sciences, Executive Plaza North, Room 5134, MSC 7393, 6130 Executive Boulevard, Bethesda, Maryland 20892-7393, USA. winnde@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 986 EP - 994 VL - 5 IS - 12 SN - 1474-175X, 1474-175X KW - Index Medicus KW - Risk Factors KW - Humans KW - Cohort Studies KW - New York -- epidemiology KW - Cluster Analysis KW - Female KW - Breast Neoplasms -- mortality KW - Environmental Exposure KW - Breast Neoplasms -- etiology KW - Breast Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68885594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+reviews.+Cancer&rft.atitle=Science+and+society%3A+the+Long+Island+Breast+Cancer+Study+Project.&rft.au=Winn%2C+Deborah+M&rft.aulast=Winn&rft.aufirst=Deborah&rft.date=2005-12-01&rft.volume=5&rft.issue=12&rft.spage=986&rft.isbn=&rft.btitle=&rft.title=Nature+reviews.+Cancer&rft.issn=1474175X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-16 N1 - Date created - 2005-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Secondary ion mass spectroscopy demonstrates retention of beryllium in chronic beryllium disease granulomas. AN - 68885496; 16340702 AB - We hypothesized that beryllium (Be) might persist in lung granulomas in patients with chronic beryllium disease (CBD). A total of 33 Be-exposed ceramics workers underwent transbronchial biopsy. They were classified based on histopathology and Be-lymphocyte proliferation test as CBD or other categories. Lung tissue sections were analyzed using secondary ion mass spectroscopy. Be was detected in the lungs of all Be-exposed groups. Be levels were increased within the granulomas of patients with CBD compared with the Be levels outside granulomas. Notably, Be was detectable in the lungs of CBD patients who had ceased exposure to Be an average of 9 years previously. Be was detected in the lungs of all Be-exposed subjects, with the highest levels of persistent Be inside CBD lung granulomas. Be antigen persistence may help explain the chronicity of this granulomatous disorder. JF - Journal of occupational and environmental medicine AU - Sawyer, Richard T AU - Abraham, Jerrold L AU - Daniloff, Elaine AU - Newman, Lee S AD - Division of Environmental and Occupational Health Sciences, Robert Hollis Laboratory of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA. sawyerr@niaid.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1218 EP - 1226 VL - 47 IS - 12 SN - 1076-2752, 1076-2752 KW - Beryllium KW - OW5102UV6N KW - Index Medicus KW - Occupational Exposure KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Chronic Disease KW - Biopsy KW - Male KW - Female KW - Berylliosis KW - Spectrometry, Mass, Secondary Ion -- methods KW - Granuloma, Respiratory Tract KW - Beryllium -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68885496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=LRP+1+B+functions+as+a+receptor+for+Pseudomonas+exotoxin.&rft.au=Pastrana%2C+Diana+V%3BHanson%2C+Alison+J%3BKnisely%2C+Jane%3BBu%2C+Guojun%3BFitzgerald%2C+David+J&rft.aulast=Pastrana&rft.aufirst=Diana&rft.date=2005-09-25&rft.volume=1741&rft.issue=3&rft.spage=234&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-14 N1 - Date created - 2005-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A pilot study of an investigational testosterone transdermal patch system in young women with spontaneous premature ovarian failure. AN - 68873895; 16174721 AB - Evidence suggests that young women with spontaneous premature ovarian failure (sPOF) have significantly lower androgen levels than age-matched regularly menstruating women. The objective of the study was to evaluate an investigational testosterone transdermal patch (TTP) designed to deliver the normal ovarian production rate of testosterone. This was an open-label study (2-month baseline period followed by 2-month treatment period). Nine women with sPOF and a history of regular bleeding patterns on standard estrogen/progestogen cyclic treatment participated in the study. One subject with abnormal baseline levels was excluded. Four consecutive 28-d cycles of transdermal estradiol (E2; 0.1 mg/d) and sequential oral medroxyprogesterone acetate (MPA; 10 mg/d for the last 12 d of each cycle). During cycles 3 and 4, an investigational TTP (nominal delivery 150 microg/d) was applied twice weekly to the abdomen. Steady-state pharmacokinetic profiles of free and total testosterone and scheduled vaginal bleeding patterns were studied. The mean (95% confidence interval) of the time-average free testosterone levels during TTP treatment was 7.5 (4.9-9.9) pg/ml; 26.0 (17.2-34.6) pmol/liter (with E2), and 6.9 (4.9-8.8) pg/ml; 23.9 (17.2-30.5) pmol/liter (with E2 and MPA). The confidence intervals of the means include the upper limit of normal for premenopausal women, i.e. 6.8 pg/ml (23.5 pmol/liter), although the mean values are slightly above this. The addition of TTP to cyclic E2/MPA therapy in women with sPOF produced mean free testosterone levels that approximate the upper limit of normal. A 3-yr study to assess safety and effectiveness in this population is in progress. JF - The Journal of clinical endocrinology and metabolism AU - Kalantaridou, Sophia N AU - Calis, Karim A AU - Mazer, Norman A AU - Godoy, Heidy AU - Nelson, Lawrence M AD - Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 6549 EP - 6552 VL - 90 IS - 12 SN - 0021-972X, 0021-972X KW - Androgens KW - 0 KW - Hormones KW - Testosterone KW - 3XMK78S47O KW - Abridged Index Medicus KW - Index Medicus KW - Administration, Cutaneous KW - Humans KW - Adult KW - Hormones -- blood KW - Pilot Projects KW - Menstrual Cycle -- drug effects KW - Female KW - Androgens -- therapeutic use KW - Testosterone -- therapeutic use KW - Testosterone -- administration & dosage KW - Primary Ovarian Insufficiency -- physiopathology KW - Primary Ovarian Insufficiency -- blood KW - Androgens -- adverse effects KW - Testosterone -- adverse effects KW - Primary Ovarian Insufficiency -- drug therapy KW - Androgens -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68873895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+endocrinology+and+metabolism&rft.atitle=A+pilot+study+of+an+investigational+testosterone+transdermal+patch+system+in+young+women+with+spontaneous+premature+ovarian+failure.&rft.au=Kalantaridou%2C+Sophia+N%3BCalis%2C+Karim+A%3BMazer%2C+Norman+A%3BGodoy%2C+Heidy%3BNelson%2C+Lawrence+M&rft.aulast=Kalantaridou&rft.aufirst=Sophia&rft.date=2005-12-01&rft.volume=90&rft.issue=12&rft.spage=6549&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+endocrinology+and+metabolism&rft.issn=0021972X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Research opportunities on alcohol and liver damage. AN - 68868252; 16317668 JF - Hepatology (Baltimore, Md.) AU - Zakhari, Samir AU - Hoofnagle, Jay H AD - Division of Metabolism and Health Effects NIAAA, National Institutes of Health Bethesda, MD, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1243 VL - 42 IS - 6 SN - 0270-9139, 0270-9139 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - United States KW - Animals KW - Humans KW - National Institute of Mental Health (U.S.) KW - Research KW - Liver -- drug effects KW - Ethanol -- toxicity KW - Ethanol -- metabolism KW - Liver Diseases, Alcoholic -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68868252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Research+opportunities+on+alcohol+and+liver+damage.&rft.au=Zakhari%2C+Samir%3BHoofnagle%2C+Jay+H&rft.aulast=Zakhari&rft.aufirst=Samir&rft.date=2005-12-01&rft.volume=42&rft.issue=6&rft.spage=1243&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-22 N1 - Date created - 2005-12-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hepatitis C virus load and survival among injection drug users in the United States. AN - 68867246; 16317675 AB - Persons chronically infected with hepatitis C virus (HCV), some of whom may be coinfected with HIV and human T-lymphotropic virus type II (HTLV-II), are at high risk for end-stage liver disease (ESLD). We evaluated whether ESLD death was associated with premorbid HCV RNA level or specific HCV protein antibodies among persons with or without HIV/HTLV-II coinfection in a cohort of 6,570 injection drug users who enrolled in 9 US cities between 1987 and 1991. We compared 84 ESLD descendents and 305 randomly selected cohort participants with detectable HCV RNA, stratified by sex, race, HIV, and HTLV-II strata. Relative hazard (RH) of ESLD death was derived from the proportional hazard model. Risk of ESLD death was unrelated to the intensity of antibodies against the HCV c-22(p), c-33(p), c-100(p), and NS5 proteins, individually or combined, but it increased with HCV RNA level (RH(adj) = 2.26 per log(10) IU/mL, 95% CI: 1.45-5.92). The association between HCV RNA level and ESLD death remained significant after adjustment for alcohol consumption (RH(adj) = 2.57 per log(10) IU/mL, 95% CI: 1.50-8.10). Deaths from AIDS (n = 45) and other causes (n = 43) were unrelated to HCV RNA (RH(adj)= 1.14 and 1.29 per log(10) IU/mL, respectively). HIV infection was not associated with ESLD risk in multivariate analyses adjusted for HCV RNA. Men had an increased risk of ESLD death in unadjusted analyses (RH = 1.92, 95% CI: 1.15-3.56) but not in multivariate analysis (RH(adj) = 0.98, 95% CI: 0.48-2.88). Non-black patients were at increased risk for ESLD death (RH(adj)= 2.76, 95% CI: 1.49-10.09). In conclusion, HCV RNA level is a predictor of ESLD death among persons with chronic HCV infection. JF - Hepatology (Baltimore, Md.) AU - Hisada, Michie AU - Chatterjee, Nilanjan AU - Kalaylioglu, Zeynep AU - Battjes, Robert J AU - Goedert, James J AD - Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA. hisadam@exchange.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1446 EP - 1452 VL - 42 IS - 6 SN - 0270-9139, 0270-9139 KW - RNA, Viral KW - 0 KW - Index Medicus KW - HIV Infections -- virology KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - RNA, Viral -- blood KW - Viral Load KW - Substance Abuse, Intravenous -- virology KW - Hepacivirus -- isolation & purification KW - Hepatitis C, Chronic -- virology KW - Substance Abuse, Intravenous -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68867246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Hepatitis+C+virus+load+and+survival+among+injection+drug+users+in+the+United+States.&rft.au=Hisada%2C+Michie%3BChatterjee%2C+Nilanjan%3BKalaylioglu%2C+Zeynep%3BBattjes%2C+Robert+J%3BGoedert%2C+James+J&rft.aulast=Hisada&rft.aufirst=Michie&rft.date=2005-12-01&rft.volume=42&rft.issue=6&rft.spage=1446&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-22 N1 - Date created - 2005-12-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Hepatology. 2005 Dec;42(6):1261-3 [16317702] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Topiramate in chronic lumbar radicular pain. AN - 68863905; 16326371 AB - Chronic lumbar radicular pain is the most common neuropathic pain syndrome. This was a double-blind, randomized, 2-period crossover trial of topiramate (50 to 400 mg) and diphenhydramine (6.25 to 50 mg) as active placebo to assess the efficacy of topiramate. Each period consisted of a 4-week escalation, a 2-week maintenance at the highest tolerated dose, and a 2-week taper. Main outcome was the mean daily leg pain score on a 0 to 10 scale during the maintenance period. Global pain relief was assessed on a 6-level category scale. In the 29 of 42 patients who completed the study, topiramate reduced leg pain by a mean of 19% (P = .065). Global pain relief scores were significantly better on topiramate (P < .005). Mean doses were topiramate 200 mg and diphenhydramine 40 mg. We concluded that topiramate treatment might reduce chronic sciatica in some patients but causes frequent side effects and dropouts. We would not recommend topiramate unless studies of alternative regimens showed a better therapeutic ratio. The anticonvulsant topiramate might reduce chronic lumbar nerve root pain through effects such as blockade of voltage-gated sodium channels and AMPA/kainite glutamate receptors, modulation of voltage-gated calcium channels, and gamma-aminobutyric acid agonist-like effects. JF - The journal of pain : official journal of the American Pain Society AU - Khoromi, Suzan AU - Patsalides, Athos AU - Parada, Suzan AU - Salehi, Vesta AU - Meegan, Jennifer M AU - Max, Mitchell B AD - Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892-1302, USA. khoromisu@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 829 EP - 836 VL - 6 IS - 12 SN - 1526-5900, 1526-5900 KW - Analgesics KW - 0 KW - Anticonvulsants KW - Ion Channels KW - Placebos KW - Receptors, Glutamate KW - topiramate KW - 0H73WJJ391 KW - Fructose KW - 30237-26-4 KW - Diphenhydramine KW - 8GTS82S83M KW - Index Medicus KW - Drug Administration Schedule KW - Double-Blind Method KW - Dose-Response Relationship, Drug KW - Receptors, Glutamate -- drug effects KW - Humans KW - Ion Channels -- drug effects KW - Anticonvulsants -- adverse effects KW - Aged KW - Anticonvulsants -- administration & dosage KW - Analgesics -- adverse effects KW - Patient Compliance -- statistics & numerical data KW - Diphenhydramine -- pharmacology KW - Adult KW - Treatment Outcome KW - Cross-Over Studies KW - Middle Aged KW - Chronic Disease KW - Analgesics -- administration & dosage KW - Male KW - Female KW - Low Back Pain -- drug therapy KW - Fructose -- analogs & derivatives KW - Intervertebral Disc Displacement -- physiopathology KW - Radiculopathy -- physiopathology KW - Fructose -- adverse effects KW - Low Back Pain -- physiopathology KW - Low Back Pain -- etiology KW - Fructose -- administration & dosage KW - Radiculopathy -- drug therapy KW - Intervertebral Disc Displacement -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68863905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+journal+of+pain+%3A+official+journal+of+the+American+Pain+Society&rft.atitle=Topiramate+in+chronic+lumbar+radicular+pain.&rft.au=Khoromi%2C+Suzan%3BPatsalides%2C+Athos%3BParada%2C+Suzan%3BSalehi%2C+Vesta%3BMeegan%2C+Jennifer+M%3BMax%2C+Mitchell+B&rft.aulast=Khoromi&rft.aufirst=Suzan&rft.date=2005-12-01&rft.volume=6&rft.issue=12&rft.spage=829&rft.isbn=&rft.btitle=&rft.title=The+journal+of+pain+%3A+official+journal+of+the+American+Pain+Society&rft.issn=15265900&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-24 N1 - Date created - 2005-12-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gateway vectors for the production of combinatorially-tagged His6-MBP fusion proteins in the cytoplasm and periplasm of Escherichia coli. AN - 68860336; 16322578 AB - Many proteins that accumulate in the form of insoluble aggregates when they are overproduced in Escherichia coli can be rendered soluble by fusing them to E. coli maltose binding protein (MBP), and this will often enable them to fold in to their biologically active conformations. Yet, although it is an excellent solubility enhancer, MBP is not a particularly good affinity tag for protein purification. To compensate for this shortcoming, we have engineered and successfully tested Gateway destination vectors for the production of dual His6MBP-tagged fusion proteins in the cytoplasm and periplasm of E. coli. The MBP moiety improves the yield and solubility of its fusion partners while the hexahistidine tag (His-tag) serves to facilitate their purification. The availability of a vector that targets His6MBP fusion proteins to the periplasm expands the utility of this dual tagging approach to include proteins that contain disulfide bonds or are toxic in the bacterial cytoplasm. JF - Protein science : a publication of the Protein Society AU - Nallamsetty, Sreedevi AU - Austin, Brian P AU - Penrose, Kerri J AU - Waugh, David S AD - National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 2964 EP - 2971 VL - 14 IS - 12 SN - 0961-8368, 0961-8368 KW - Carrier Proteins KW - 0 KW - His-His-His-His-His-His KW - Maltose-Binding Proteins KW - Oligopeptides KW - Recombinant Fusion Proteins KW - Histidine KW - 4QD397987E KW - Ribonucleases KW - EC 3.1.- KW - Index Medicus KW - Recombinant Fusion Proteins -- metabolism KW - Base Sequence KW - Solubility KW - Ribonucleases -- isolation & purification KW - Ribonucleases -- genetics KW - Recombinant Fusion Proteins -- isolation & purification KW - Recombinant Fusion Proteins -- genetics KW - Molecular Sequence Data KW - Gene Expression KW - Ribonucleases -- chemistry KW - Amino Acid Sequence KW - Genetic Vectors -- genetics KW - Ribonucleases -- metabolism KW - Escherichia coli -- metabolism KW - Carrier Proteins -- metabolism KW - Cytoplasm -- metabolism KW - Histidine -- genetics KW - Escherichia coli -- cytology KW - Carrier Proteins -- genetics KW - Periplasm -- metabolism KW - Oligopeptides -- genetics KW - Oligopeptides -- metabolism KW - Escherichia coli -- genetics KW - Histidine -- metabolism KW - Carrier Proteins -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68860336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+International+Meeting+of+the+European+Society+of+Gynaecological+Oncology+%28ESGO+14%29&rft.atitle=Age+and+Results+of+Treatment+of+Atypical+Glandular+Cells&rft.au=Figueiredo%2C+E.M.A.%3BGiorgi%2C+R%3BMagalhaes%2C+C.M.G.%3BMoralez%2C+G+M&rft.aulast=Figueiredo&rft.aufirst=E.M.A.&rft.date=2005-09-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+International+Meeting+of+the+European+Society+of+Gynaecological+Oncology+%28ESGO+14%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-03 N1 - Date created - 2005-12-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Biochem. 2000 Jan;267(2):566-72 [10632727] Trends Biotechnol. 2005 Jun;23(6):316-20 [15922084] Structure. 2000 Sep 15;8(9):R177-85 [10986469] Protein Eng. 2001 Apr;14(4):297-305 [11391022] Toxicon. 2001 Oct;39(10):1595-600 [11478968] J Mol Biol. 2001 Sep 7;312(1):79-93 [11545587] Protein Sci. 2002 Feb;11(2):313-21 [11790841] Protein Eng. 2001 Dec;14(12):993-1000 [11809930] Acta Crystallogr D Biol Crystallogr. 2002 Mar;58(Pt 3):398-406 [11856824] Cancer Lett. 2005 Jul 28;225(2):225-36 [15978327] Methods Mol Biol. 2007;363:1-19 [17272834] Eur J Biochem. 2002 Apr;269(7):1854-65 [11952787] Protein Sci. 2002 Jul;11(7):1714-9 [12070324] Methods Mol Biol. 2003;205:99-117 [12491882] FEBS Lett. 2003 Feb 27;537(1-3):53-7 [12606030] J Struct Funct Genomics. 2002;2(2):83-92 [12836665] Biochemistry. 2003 Nov 18;42(45):13202-11 [14609331] Protein Expr Purif. 2003 Dec;32(2):194-201 [14965764] Curr Opin Struct Biol. 2004 Oct;14(5):577-83 [15465318] Protein Expr Purif. 2004 Nov;38(1):108-15 [15477088] J Bacteriol. 1967 Dec;94(6):1934-45 [4294595] Gene. 1983 Nov;25(2-3):167-78 [6363212] Protein Eng. 1995 Mar;8(3):261-73 [7479688] Protein Expr Purif. 1997 Aug;10(3):309-19 [9268677] Protein Sci. 1999 Aug;8(8):1668-74 [10452611] Mol Biotechnol. 2000 May;15(1):51-63 [10911622] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study. AN - 68852939; 16283570 AB - Cytotoxic T lymphocyte-associated antigen (CTLA)-4 can inhibit T-cell responses and is involved in tolerance against self antigens. We previously reported autoimmune manifestations and objective cancer regressions in patients with metastatic melanoma treated with CTLA-4 blockade. The possibility of activating tumor-reactive T cells while removing inhibitory activity with CTLA-4 blockade has stimulated interest in using anti-CTLA-4 antibodies in combination with other cancer immunotherapies to improve clinical outcomes. In this study, we assessed the antitumor activity and autoimmune toxicity of CTLA-4 blockade in combination with an immune-activating stimulus, interleukin (IL)-2, in patients with metastatic melanoma. Thirty-six patients received anti-CTLA-4 antibody every 3 weeks. Three patients per cohort received doses of .1, .3, 1.0, and 2.0 mg/kg. Twenty-four patients received 3.0 mg/kg. All patients received IL-2 therapy (720,000 IU/kg every 8 hours to a maximum of 15 doses). Eight patients (22%) experienced objective tumor responses (three complete and five partial), including metastases in the lungs, lymph nodes, mediastinum, and subcutaneous tissues. Six of the eight patients have ongoing objective responses at 11 to 19 months. Five patients (14%) developed grade III/IV autoimmune toxicities secondary to anti-CTLA-4 administration, including four patients with enterocolitis and one with arthritis and uveitis. There is not evidence to support a synergistic effect of CTLA-4 blockade plus IL-2 administration, because the 22% objective response rate is that expected from the sum of these two agents administered alone. Durable cancer regressions were seen in patients treated with this combination. JF - Annals of surgical oncology AU - Maker, Ajay V AU - Phan, Giao Q AU - Attia, Peter AU - Yang, James C AU - Sherry, Richard M AU - Topalian, Suzanne L AU - Kammula, Udai S AU - Royal, Richard E AU - Haworth, Leah R AU - Levy, Catherine AU - Kleiner, David AU - Mavroukakis, Sharon A AU - Yellin, Michael AU - Rosenberg, Steven A AD - Surgery Branch, National Cancer Institute, National Institutes of Health, CRC Room 3-3940, 10 Center Drive, MSC 1201, Bethesda, MD 20814, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1005 EP - 1016 VL - 12 IS - 12 SN - 1068-9265, 1068-9265 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, CD KW - Antigens, Differentiation KW - CTLA-4 Antigen KW - CTLA4 protein, human KW - Immunosuppressive Agents KW - Interleukin-2 KW - ipilimumab KW - 6T8C155666 KW - Index Medicus KW - Drug Therapy, Combination KW - Humans KW - Adult KW - Tomography, X-Ray Computed KW - Autoimmunity KW - Middle Aged KW - Flow Cytometry KW - Male KW - Female KW - Melanoma -- diagnostic imaging KW - Skin Neoplasms -- immunology KW - Melanoma -- secondary KW - Antigens, Differentiation -- therapeutic use KW - Melanoma -- immunology KW - Skin Neoplasms -- secondary KW - Antibodies, Monoclonal -- therapeutic use KW - Immunotherapy -- methods KW - Skin Neoplasms -- drug therapy KW - Antibodies, Monoclonal -- pharmacokinetics KW - Interleukin-2 -- therapeutic use KW - Melanoma -- drug therapy KW - Skin Neoplasms -- diagnostic imaging KW - Immunosuppressive Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68852939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+surgical+oncology&rft.atitle=Tumor+regression+and+autoimmunity+in+patients+treated+with+cytotoxic+T+lymphocyte-associated+antigen+4+blockade+and+interleukin+2%3A+a+phase+I%2FII+study.&rft.au=Maker%2C+Ajay+V%3BPhan%2C+Giao+Q%3BAttia%2C+Peter%3BYang%2C+James+C%3BSherry%2C+Richard+M%3BTopalian%2C+Suzanne+L%3BKammula%2C+Udai+S%3BRoyal%2C+Richard+E%3BHaworth%2C+Leah+R%3BLevy%2C+Catherine%3BKleiner%2C+David%3BMavroukakis%2C+Sharon+A%3BYellin%2C+Michael%3BRosenberg%2C+Steven+A&rft.aulast=Maker&rft.aufirst=Ajay&rft.date=2005-12-01&rft.volume=12&rft.issue=12&rft.spage=1005&rft.isbn=&rft.btitle=&rft.title=Annals+of+surgical+oncology&rft.issn=10689265&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-09 N1 - Date created - 2005-12-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunother. 2001 Jul-Aug;24(4):287-93 [11565830] Nat Immunol. 2002 Jul;3(7):611-8 [12087419] Annu Rev Immunol. 1996;14:233-58 [8717514] J Exp Med. 1996 Jun 1;183(6):2541-50 [8676075] J Exp Med. 1996 Jun 1;183(6):2533-40 [8676074] Science. 1996 Mar 22;271(5256):1734-6 [8596936] Science. 1995 Nov 10;270(5238):985-8 [7481803] J Immunol. 1993 Oct 1;151(7):3489-99 [8397258] J Immunol. 1992 Jul 15;149(2):380-8 [1320641] J Exp Med. 1991 Sep 1;174(3):561-9 [1714933] Science. 1990 Jun 15;248(4961):1349-56 [2113314] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8372-7 [12826605] J Immunol. 1996 Aug 15;157(4):1333-6 [8759711] J Neuroimmunol. 1997 Mar;73(1-2):57-62 [9058759] Immunity. 1997 Oct;7(4):445-50 [9354465] J Exp Med. 1998 Feb 2;187(3):427-32 [9449722] Ann Surg. 1998 Sep;228(3):307-19 [9742914] J Exp Med. 2000 Jul 17;192(2):303-10 [10899917] J Exp Med. 2000 Jul 17;192(2):295-302 [10899916] Cancer Res. 2000 May 1;60(9):2444-8 [10811122] J Clin Oncol. 1999 Jul;17(7):2105-16 [10561265] J Clin Oncol. 2005 Sep 1;23(25):6043-53 [16087944] Eur J Immunol. 2004 Dec;34(12):3485-96 [15484187] J Exp Med. 1999 Aug 2;190(3):355-66 [10430624] J Immunol. 1999 May 15;162(10):5813-20 [10229815] Comment In: Ann Surg Oncol. 2005 Dec;12(12):957-9 [16244797] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tenofovir disoproxil fumarate and an optimized background regimen of antiretroviral agents as salvage therapy for pediatric HIV infection. AN - 68848556; 16291735 AB - Highly active antiretroviral therapy has altered the course of HIV infection among children, but new antiretroviral agents are needed for treatment-experienced children with drug-resistant virus. Tenofovir disoproxil fumarate (DF) is a promising agent for use in pediatric salvage therapy, because of its tolerability, efficacy, and resistance profile. We designed this study to provide preliminary pediatric safety and dosing information on tenofovir DF, while also providing potentially efficacious salvage therapy for heavily treatment-experienced, HIV-infected children. Tenofovir DF, alone and in combination with optimized background antiretroviral regimens, was studied among 18 HIV-infected children (age range: 8.3-16.2 years) who had progressive disease with > or = 2 prior antiretroviral regimens, in a single-center, open-label trial. Tenofovir DF monotherapy for 6 days was followed by the addition of individualized antiretroviral regimens. Subjects were monitored with HIV RNA reverse transcription-polymerase chain reaction, flow cytometry, and routine laboratory studies; monitoring for bone toxicity included measurement of lumbar spine bone mineral density (BMD) with dual-energy x-ray absorptiometry. Subjects were monitored through 48 weeks. Two subjects developed grade 3 elevated hepatic transaminase levels during monotherapy and were removed from the study. The remaining 16 subjects had a median of 4 antiretroviral agents (range: 3-5 agents) added to tenofovir DF. HIV plasma RNA levels decreased from a median pretreatment level of 5.4 log10 copies per mL (range: 4.1-5.9 log10 copies per mL) to 4.21 log10 copies per mL at week 48 (n = 15), with 6 subjects having 6% decrease in BMD for 5 of 15 subjects evaluated at week 48, necessitating the discontinuation of tenofovir DF therapy for 2; all 5 subjects experienced >2 log10 copies per mL decreases in HIV plasma RNA levels. Tenofovir DF-containing, individualized, highly active antiretroviral therapy regimens were well tolerated and effective among heavily treatment-experienced, HIV-infected children. Loss of BMD may limit tenofovir DF use among prepubertal patients. JF - Pediatrics AU - Hazra, Rohan AU - Gafni, Rachel I AU - Maldarelli, Frank AU - Balis, Frank M AU - Tullio, Antonella N AU - DeCarlo, Ellen AU - Worrell, Carol J AU - Steinberg, Seth M AU - Flaherty, John AU - Yale, Kitty AU - Kearney, Brian P AU - Zeichner, Steven L AD - HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - e846 EP - e854 VL - 116 IS - 6 KW - Anti-HIV Agents KW - 0 KW - Organophosphonates KW - Tenofovir KW - 99YXE507IL KW - Adenine KW - JAC85A2161 KW - Abridged Index Medicus KW - Index Medicus KW - Viral Load KW - Drug Resistance, Viral KW - Humans KW - Salvage Therapy KW - Antiretroviral Therapy, Highly Active KW - Child KW - CD4 Lymphocyte Count KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Adenine -- therapeutic use KW - Organophosphonates -- therapeutic use KW - Anti-HIV Agents -- therapeutic use KW - HIV Infections -- drug therapy KW - Adenine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68848556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Tenofovir+disoproxil+fumarate+and+an+optimized+background+regimen+of+antiretroviral+agents+as+salvage+therapy+for+pediatric+HIV+infection.&rft.au=Hazra%2C+Rohan%3BGafni%2C+Rachel+I%3BMaldarelli%2C+Frank%3BBalis%2C+Frank+M%3BTullio%2C+Antonella+N%3BDeCarlo%2C+Ellen%3BWorrell%2C+Carol+J%3BSteinberg%2C+Seth+M%3BFlaherty%2C+John%3BYale%2C+Kitty%3BKearney%2C+Brian+P%3BZeichner%2C+Steven+L&rft.aulast=Hazra&rft.aufirst=Rohan&rft.date=2005-12-01&rft.volume=116&rft.issue=6&rft.spage=e846&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=1098-4275&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-22 N1 - Date created - 2005-12-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hematopoietic stem cell gene therapy: dead or alive? AN - 68847047; 16216357 AB - Despite some reports of toxicity in recent clinical trials, many scientists believe that the use of gene therapy in the treatment of congenital genetic defects and acquired disorders has too much potential to abandon. Hematopoietic stem cells (HSCs) have been primary targets for gene therapy owing to their capacity for differentiation and self-renewal, whereby multiple cell lineages can potentially be corrected for the lifetime of an individual. These efforts represent a long-term investment towards broadening physicians' treatment options for patients whose diseases, in particular certain immunodeficiencies, are fatal and where no other therapy is available. We review the recent progress and clinical triumphs as well as the reported toxicity related to insertional mutagenesis. We also discuss the current risk-to-benefit estimates and future strategies to reduce the risks and allow full realization of clinical potential. Scientists are continually revising protocols: going both from "bench to bedside" and, as strikingly demonstrated by HSC gene therapy, from "bedside to bench." JF - Trends in biotechnology AU - Ferguson, Cole AU - Larochelle, Andre AU - Dunbar, Cynthia E AD - Molecular Hematopoiesis Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 589 EP - 597 VL - 23 IS - 12 SN - 0167-7799, 0167-7799 KW - Index Medicus KW - Animals KW - Severe Combined Immunodeficiency -- therapy KW - Gene Transfer Techniques KW - Humans KW - Clinical Trials as Topic KW - Disease Models, Animal KW - Forecasting KW - Severe Combined Immunodeficiency -- genetics KW - Mutagenesis, Insertional KW - Hematopoietic Stem Cells KW - Genetic Therapy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68847047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+biotechnology&rft.atitle=Hematopoietic+stem+cell+gene+therapy%3A+dead+or+alive%3F&rft.au=Ferguson%2C+Cole%3BLarochelle%2C+Andre%3BDunbar%2C+Cynthia+E&rft.aulast=Ferguson&rft.aufirst=Cole&rft.date=2005-12-01&rft.volume=23&rft.issue=12&rft.spage=589&rft.isbn=&rft.btitle=&rft.title=Trends+in+biotechnology&rft.issn=01677799&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-18 N1 - Date created - 2005-11-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Can experimental paradigms and animal models be used to discover clinically effective medications for alcoholism? AN - 68843169; 16318951 AB - Evaluating medications in animal laboratory paradigms can reveal whether the compound is effective in an established alcoholism model, at clinically relevant doses and exposure conditions, when administered orally (or transdermally) and without serious limiting side effects. Positive outcomes constitute a possible discovery for relevance to alcoholism and, under favorable marketing conditions, encourage further development. Medication testing using animal models of alcoholism might also guide clinical testing by discriminating clinically effective from clinically ineffective compounds. This ability rests on whether there are tests or, more reasonably, batteries of tests having this discriminative ability. The present paper examines this possibility. Effects of naltrexone and acamprosate in animal paradigms which model behavioral aspects of alcoholism are reviewed and compared with the effects of compounds which have limited effects in alcoholics. It is not clear at present whether any single paradigm or combination of paradigms differentiates clinically effective from clinically limited compounds. Steps are suggested to improve the use of preclinical laboratory tests to predict which compounds are likely to be effective medications for reducing drinking and sustaining abstinence in human alcoholics. JF - Addiction biology AU - Egli, Mark AD - Division of Neuroscience and Behavior, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services Bethesda, MD 20892-9304, USA. megli@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 309 EP - 319 VL - 10 IS - 4 SN - 1355-6215, 1355-6215 KW - Alcohol Deterrents KW - 0 KW - Taurine KW - 1EQV5MLY3D KW - Naltrexone KW - 5S6W795CQM KW - acamprosate KW - N4K14YGM3J KW - Index Medicus KW - Taurine -- analogs & derivatives KW - Naltrexone -- administration & dosage KW - Animals KW - Taurine -- toxicity KW - Humans KW - Clinical Trials as Topic KW - Taurine -- administration & dosage KW - Rodentia KW - Drug Evaluation, Preclinical KW - Naltrexone -- toxicity KW - Alcoholism -- rehabilitation KW - Disease Models, Animal KW - Alcohol Deterrents -- administration & dosage KW - Alcohol Deterrents -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68843169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+biology&rft.atitle=Can+experimental+paradigms+and+animal+models+be+used+to+discover+clinically+effective+medications+for+alcoholism%3F&rft.au=Egli%2C+Mark&rft.aulast=Egli&rft.aufirst=Mark&rft.date=2005-12-01&rft.volume=10&rft.issue=4&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Addiction+biology&rft.issn=13556215&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-03 N1 - Date created - 2005-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Molecularly targeted therapy for pediatric brain tumors. AN - 68839572; 16195796 AB - Treatment of pediatric brain tumors remains a challenge because of the toxicity associated with conventional treatment and the relative resistance of tumors at the time of recurrence. The traditional approach of administering cytotoxic agents at the maximum tolerated dose is being supplanted by the development of molecularly targeted agents aimed at critical cellular changes that are responsible for the growth and spread of cancer cells. These agents theoretically should be more specific for tumor cells and less toxic to normal cells. While the idea of targeted therapy has generated much excitement in the oncology community, the degree of benefit to patients with central nervous system (CNS) tumors remains unclear. Numerous challenges remain in the development of these agents, including identification of meaningful targets, delivery of agents in sufficient quantity at the target site, and determination of any biologic response to these agents. This article discusses the rationale behind several of these agents and their use in pediatric patients with brain tumors. JF - Journal of neuro-oncology AU - K E, Warren AD - National Cancer Institute, Neuro-Oncology Branch, Bloch Bldg, 82, Rm 224, 9030 Old Georgetown Road, Bethesda, Maryland 20892-8200, USA. warrenk@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 335 EP - 343 VL - 75 IS - 3 SN - 0167-594X, 0167-594X KW - Antineoplastic Agents KW - 0 KW - Enzyme Inhibitors KW - Platelet-Derived Growth Factor KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Receptor, Epidermal Growth Factor -- drug effects KW - Humans KW - Platelet-Derived Growth Factor -- drug effects KW - Receptor, Epidermal Growth Factor -- physiology KW - Child KW - Platelet-Derived Growth Factor -- physiology KW - Enzyme Inhibitors -- therapeutic use KW - Brain Neoplasms -- drug therapy KW - Brain Neoplasms -- genetics KW - Enzyme Inhibitors -- pharmacology KW - Brain Neoplasms -- physiopathology KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68839572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuro-oncology&rft.atitle=Molecularly+targeted+therapy+for+pediatric+brain+tumors.&rft.au=K+E%2C+Warren&rft.aulast=K+E&rft.aufirst=Warren&rft.date=2005-12-01&rft.volume=75&rft.issue=3&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuro-oncology&rft.issn=0167594X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-28 N1 - Date created - 2005-11-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Endogenous PACAP acts as a stress response peptide to protect cerebellar neurons from ethanol or oxidative insult. AN - 68831645; 16009465 AB - The rodent cerebellum is richly supplied with PACAPergic innervation. Exogenous pituitary adenylate cyclase-activating polypeptide (PACAP) increases cerebellar granule cell survival and differentiation in culture, and enhances the number of neuroblasts in the molecular and internal granule cell layers (IGL) when injected postnatally into the cerebellum in vivo. Here, we have investigated the role of endogenous PACAP during cerebellar development by comparing the morphology of normal and PACAP-deficient mouse cerebellum, and the response of cerebellar granule cells from normal and PACAP-deficient mice subjected to neurotoxic insult in culture. There was no difference in cerebellar volume or granule cell number, in 11-day-old wild type versus PACAP-deficient mice. Cultured cerebellar neurons from PACAP-deficient and wild type mice also showed no apparent differences in survival and differentiation either under depolarizing conditions, or non-depolarizing conditions in the presence or absence of either dibutyryl cAMP or 100 nM PACAP. However, cultured cerebellar neurons from PACAP-deficient mice were significantly more sensitive than wild type neurons to ethanol- or hydrogen peroxide-induced toxicity. Differential ethanol toxicity was reversed by addition of 100 nM exogenous PACAP, suggesting that endogenous PACAP has neuroprotective activity in the context of cellular insult or stress. The neuroprotective action of PACAP was mimicked by dibutryl cAMP, indicating that it occurred via activation of adenylate cyclase. These results indicate that PACAP might act to protect the brain from paraphysiological insult, including exposure to toxins or hypoxia. JF - Peptides AU - Vaudry, David AU - Hamelink, Carol AU - Damadzic, Ruslan AU - Eskay, Robert L AU - Gonzalez, Bruno AU - Eiden, Lee E AD - Section on Molecular Neuroscience, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, 49 Convent Drive, Rm. 5A68, MSC 4090, 9000 Rockville Pike, Bethesda, MD 20892-4483, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 2518 EP - 2524 VL - 26 IS - 12 SN - 0196-9781, 0196-9781 KW - Anti-Infective Agents, Local KW - 0 KW - Pituitary Adenylate Cyclase-Activating Polypeptide KW - Ethanol KW - 3K9958V90M KW - Hydrogen Peroxide KW - BBX060AN9V KW - Index Medicus KW - Animals KW - Cells, Cultured KW - Mice KW - Mice, Knockout KW - Hydrogen Peroxide -- toxicity KW - Cerebellum -- cytology KW - Neurons -- metabolism KW - Pituitary Adenylate Cyclase-Activating Polypeptide -- pharmacology KW - Cerebellum -- growth & development KW - Neurons -- cytology KW - Oxidative Stress -- drug effects KW - Ethanol -- toxicity KW - Anti-Infective Agents, Local -- toxicity KW - Pituitary Adenylate Cyclase-Activating Polypeptide -- metabolism KW - Pituitary Adenylate Cyclase-Activating Polypeptide -- deficiency KW - Cerebellum -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68831645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Peptides&rft.atitle=Endogenous+PACAP+acts+as+a+stress+response+peptide+to+protect+cerebellar+neurons+from+ethanol+or+oxidative+insult.&rft.au=Vaudry%2C+David%3BHamelink%2C+Carol%3BDamadzic%2C+Ruslan%3BEskay%2C+Robert+L%3BGonzalez%2C+Bruno%3BEiden%2C+Lee+E&rft.aulast=Vaudry&rft.aufirst=David&rft.date=2005-12-01&rft.volume=26&rft.issue=12&rft.spage=2518&rft.isbn=&rft.btitle=&rft.title=Peptides&rft.issn=01969781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-28 N1 - Date created - 2005-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Novel molecular targeted therapy for esophageal cancer. AN - 68825908; 16299785 AB - Esophageal cancers are highly lethal neoplasms which are generally refractory to conventional multidisciplinary interventions. Recent elucidation of the mechanisms of esophageal carcinogenesis, as well as preclinical studies utilizing chromatin remodeling agents and inhibitors of oncogene signaling in conjunction with conventional chemotherapeutic agents provide new opportunities for the development of potentially efficacious molecular targeted therapies for these malignancies. (c) 2005 Wiley-Liss, Inc. JF - Journal of surgical oncology AU - Schrump, David S AU - Nguyen, Dao M AD - Thoracic Oncology Section, Surgery Branch, National Cancer Institute, Bldg. 10, Rm. 4-3490, 10 Center Drive MSC 1201, Bethesda, MD 20892, USA. David_Schrump@nih.gov Y1 - 2005/12/01/ PY - 2005 DA - 2005 Dec 01 SP - 257 EP - 261 VL - 92 IS - 3 SN - 0022-4790, 0022-4790 KW - Depsipeptides KW - 0 KW - Glycoproteins KW - Histone Deacetylase Inhibitors KW - tissue-factor-pathway inhibitor 2 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Animals KW - Drug Screening Assays, Antitumor KW - Apoptosis KW - Genes, Tumor Suppressor KW - Humans KW - Clinical Trials as Topic KW - Paclitaxel -- pharmacology KW - Adenocarcinoma -- genetics KW - Mitogen-Activated Protein Kinases -- physiology KW - Adenocarcinoma -- pathology KW - Gene Expression Regulation, Neoplastic KW - Barrett Esophagus -- pathology KW - DNA Methylation KW - Glycoproteins -- metabolism KW - Barrett Esophagus -- genetics KW - Depsipeptides -- pharmacology KW - Protein Kinase C -- physiology KW - Signal Transduction KW - Cell Transformation, Neoplastic KW - Esophageal Neoplasms -- prevention & control KW - Esophageal Neoplasms -- metabolism KW - Esophageal Neoplasms -- genetics KW - Esophageal Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68825908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+surgical+oncology&rft.atitle=Novel+molecular+targeted+therapy+for+esophageal+cancer.&rft.au=Schrump%2C+David+S%3BNguyen%2C+Dao+M&rft.aulast=Schrump&rft.aufirst=David&rft.date=2005-12-01&rft.volume=92&rft.issue=3&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Journal+of+surgical+oncology&rft.issn=00224790&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-23 N1 - Date created - 2005-11-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevalence, correlates, co-morbidity, and comparative disability of DSM-IV generalized anxiety disorder in the USA: results from the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 68824459; 16202187 AB - This study addressed the prevalences, correlates, co-morbidity and disability of DSM-IV generalized anxiety disorder (GAD) and other psychiatric disorders in a large national survey of the general population, the National Institute on Alcohol Abuse and Alcoholism's (NIAAA) National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). The study presents nationally representative data, for the first time, on prevalence, correlates, co-morbidity, and comparative disability of DSM-IV GAD. Data are taken from a large (n=43093) representative sample of the adult USA population.R: Prevalences of 12-month and lifetime GAD were 2.1% and 4.1%. Being female, middle-aged, widowed/separated/divorced, and low income increased risk, while being Asian, Hispanic, or Black decreased risk. GAD was highly co-morbid with substance use, and other anxiety, mood, and personality disorders. Co-morbidity in GAD was not substantially greater than for most other Axis I and II disorders. Disability and impairment in pure GAD were equivalent to pure mood disorders, but significantly greater than in pure substance use, and other anxiety and personality disorders. Individuals co-morbid for GAD and each mood disorder were more disabled than those with pure forms of GAD or each mood disorder. When co-morbid with GAD, nicotine dependence and other anxiety and personality disorders were not associated with increased disability over that associated with pure GAD, but GAD did show increased disability over that due to each of these disorders in pure form.Conclusions. Associations between GAD and Axis I and II disorders were strong and significant, with variation among specific disorders. Results strongly support GAD as an independent disorder with significant impairment and disability. JF - Psychological medicine AU - Grant, Bridget F AU - Hasin, Deborah S AU - Stinson, Frederick S AU - Dawson, Deborah A AU - June Ruan, W AU - Goldstein, Risë B AU - Smith, Sharon M AU - Saha, Tulshi D AU - Huang, Boji AD - Laboratory of Epidemiology and Biometry, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-9304, USA. bgrant@willco.niaaa.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1747 EP - 1759 VL - 35 IS - 12 SN - 0033-2917, 0033-2917 KW - Index Medicus KW - United States KW - Severity of Illness Index KW - Humans KW - Adult KW - Middle Aged KW - Adolescent KW - Sex Distribution KW - Male KW - Female KW - Comorbidity KW - Prevalence KW - Alcoholism -- epidemiology KW - Anxiety Disorders -- psychology KW - Alcoholism -- diagnosis KW - Anxiety Disorders -- diagnosis KW - Disability Evaluation KW - Anxiety Disorders -- epidemiology KW - Diagnostic and Statistical Manual of Mental Disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68824459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+medicine&rft.atitle=Prevalence%2C+correlates%2C+co-morbidity%2C+and+comparative+disability+of+DSM-IV+generalized+anxiety+disorder+in+the+USA%3A+results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Grant%2C+Bridget+F%3BHasin%2C+Deborah+S%3BStinson%2C+Frederick+S%3BDawson%2C+Deborah+A%3BJune+Ruan%2C+W%3BGoldstein%2C+Ris%C3%AB+B%3BSmith%2C+Sharon+M%3BSaha%2C+Tulshi+D%3BHuang%2C+Boji&rft.aulast=Grant&rft.aufirst=Bridget&rft.date=2005-12-01&rft.volume=35&rft.issue=12&rft.spage=1747&rft.isbn=&rft.btitle=&rft.title=Psychological+medicine&rft.issn=00332917&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-10 N1 - Date created - 2005-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Childhood exposure to environmental tobacco smoke and chronic respiratory symptoms in non-smoking adults: the Singapore Chinese Health Study. AN - 68819506; 16131525 AB - Childhood exposure to environmental tobacco smoke has been extensively associated with childhood respiratory illness; fewer studies have addressed the effects on adults. Childhood environmental tobacco smoke exposure in relation to chronic cough, phlegm, and asthma diagnosis was studied in never smokers from a cohort of Singaporeans of Chinese ethnicity aged 45-74 years at enrollment from 1993 to 1998. From 1999 to 2004 subjects were interviewed regarding environmental tobacco smoke exposure before and after the age of 18 and the presence and duration of current symptoms of chronic cough and phlegm production and asthma diagnosis. Among 35,000 never smokers, fewer had smoking mothers (19%) than fathers (48%). Although few subjects currently lived (20%) or worked (4%) with smokers, 65% reported living with a daily smoker before the age of 18 years. Living with a smoker before the age of 18 increased the odds of chronic dry cough (149 cases, odds ratio 2.1, 95% CI 1.4 to 3.3) and, to a lesser extent, phlegm, after adjustment for age, sex, dialect group, and current and past exposure to smokers at home and at work after the age of 18. Associations strengthened with higher numbers of smokers in childhood. There was no association with asthma or chronic bronchitis. There was evidence to suggest a stronger association among subjects with a lower adult intake of fibre which has previously been found to be protective for respiratory symptoms. In this large study of non-smokers, living with a smoker in childhood was associated with chronic dry cough and phlegm in adulthood, independent of later exposures to environmental tobacco smoke. JF - Thorax AU - David, G L AU - Koh, W-P AU - Lee, H-P AU - Yu, M C AU - London, S J AD - Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, P O Box 12233, Mail Drop A3-05, Research Triangle Park, NC 27709, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1052 EP - 1058 VL - 60 IS - 12 SN - 0040-6376, 0040-6376 KW - Tobacco Smoke Pollution KW - 0 KW - Index Medicus KW - Humans KW - Infant, Newborn KW - Aged KW - Child KW - Child, Preschool KW - Cough -- etiology KW - Infant KW - Singapore -- epidemiology KW - Adult KW - Cough -- ethnology KW - Middle Aged KW - Chronic Disease KW - Adolescent KW - China -- ethnology KW - Male KW - Female KW - Tobacco Smoke Pollution -- statistics & numerical data KW - Respiratory Tract Diseases -- etiology KW - Respiratory Tract Diseases -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68819506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Thorax&rft.atitle=Childhood+exposure+to+environmental+tobacco+smoke+and+chronic+respiratory+symptoms+in+non-smoking+adults%3A+the+Singapore+Chinese+Health+Study.&rft.au=David%2C+G+L%3BKoh%2C+W-P%3BLee%2C+H-P%3BYu%2C+M+C%3BLondon%2C+S+J&rft.aulast=David&rft.aufirst=G&rft.date=2005-12-01&rft.volume=60&rft.issue=12&rft.spage=1052&rft.isbn=&rft.btitle=&rft.title=Thorax&rft.issn=00406376&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-19 N1 - Date created - 2005-11-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Respir Crit Care Med. 1997 Nov;156(5):1447-52 [9372659] J Asthma. 1997;34(1):67-76 [9033442] Am J Respir Crit Care Med. 1998 Sep;158(3):802-6 [9731008] Am J Respir Crit Care Med. 1998 Nov;158(5 Pt 1):1493-8 [9817698] Am J Respir Crit Care Med. 1999 Apr;159(4 Pt 1):1257-66 [10194174] Thorax. 1999 Apr;54(4):357-66 [10092699] JAMA. 2005 Sep 28;294(12):1505-10 [16189363] QJM. 1999 Sep;92(9):527-30 [10627873] Environ Health Perspect. 2001 Aug;109 Suppl 4:573-8 [11544166] Chest. 2001 Sep;120(3):711-7 [11555497] Nutr Cancer. 2001;39(2):187-95 [11759279] J Epidemiol Community Health. 2002 Mar;56(3):167-70 [11854334] Am J Clin Nutr. 2002 Mar;75(3):492-8 [11864854] Epidemiology. 2002 May;13(3):268-76 [11964927] Scand J Work Environ Health. 2002;28 Suppl 2:52-70 [12058803] Am J Respir Crit Care Med. 2003 Jan 1;167(1):45-9 [12502475] Am J Respir Crit Care Med. 2003 Mar 15;167(6):911-6 [12623860] Cancer Epidemiol Biomarkers Prev. 2003 Sep;12(9):890-8 [14504200] N Engl J Med. 2003 Oct 9;349(15):1414-22 [14534334] Diabetes Care. 2004 Mar;27(3):752-7 [14988297] Thorax. 2004 Apr;59(4):274-6 [15047943] Thorax. 2004 Apr;59(4):295-302 [15047948] J Allergy Clin Immunol. 2004 May;113(5):845-52 [15131565] Am J Respir Crit Care Med. 2004 Aug 1;170(3):279-87 [15117740] Am Rev Respir Dis. 1978 Dec;118(6 Pt 2):1-120 [742764] Am Rev Respir Dis. 1986 Jun;133(6):1171-80 [3717766] Singapore Med J. 1988 Apr;29(2):119-24 [3399913] Singapore Med J. 1988 Jun;29(3):233-9 [3187574] Am Rev Respir Dis. 1988 Aug;138(2):296-9 [3195829] Int J Epidemiol. 1993 Oct;22(5):809-17 [8282459] BMJ. 1994 Jul 9;309(6947):90-3 [8038673] Am J Respir Crit Care Med. 1994 Nov;150(5 Pt 1):1222-8 [7952544] Eur J Clin Nutr. 1994 Jul;48(7):522-4 [7956995] J AOAC Int. 1995 Jan-Feb;78(1):22-36 [7703724] JAMA. 1996 Apr 24;275(16):1233-40 [8601954] BMJ. 1996 May 11;312(7040):1195-9 [8634562] Lancet. 1998 Aug 8;352(9126):453 [9708758] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Incidence of haematopoietic malignancies in US radiologic technologists. AN - 68819095; 16299095 AB - There are limited data on risks of haematopoietic malignancies associated with protracted low-to-moderate dose radiation. To contribute the first incidence risk estimates for haematopoietic malignancies in relation to work history, procedures, practices, and protective measures in a large population of mostly female medical radiation workers. The investigators followed up 71,894 (77.9% female) US radiologic technologists, first certified during 1926-80, from completion of a baseline questionnaire (1983-89) to return of a second questionnaire (1994-98), diagnosis of a first cancer, death, or 31 August 1998 (731,306 person-years), whichever occurred first. Cox proportional hazards regression was used to compute risks. Relative risks (RR) for leukaemias other than chronic lymphocytic leukaemia (non-CLL, 41 cases) were increased among technologists working five or more years before 1950 (RR = 6.6, 95% CI 1.0 to 41.9, based on seven cases) or holding patients 50 or more times for x ray examination (RR = 2.6, 95% CI 1.3 to 5.4). Risks of non-CLL leukaemias were not significantly related to the number of years subjects worked in more recent periods, the year or age first worked, the total years worked, specific procedures or equipment used, or personal radiotherapy. Working as a radiologic technologist was not significantly linked with risk of multiple myeloma (28 cases), non-Hodgkin's lymphoma (118 cases), Hodgkin's lymphoma (31 cases), or chronic lymphocytic leukaemia (23 cases). Similar to results for single acute dose and fractionated high dose radiation exposures, there was increased risk for non-CLL leukaemias decades after initial protracted radiation exposure that likely cumulated to low-to-moderate doses. JF - Occupational and environmental medicine AU - Linet, M S AU - Freedman, D M AU - Mohan, A K AU - Doody, M M AU - Ron, E AU - Mabuchi, K AU - Alexander, B H AU - Sigurdson, A AU - Hauptmann, M AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA. linetm@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 861 EP - 867 VL - 62 IS - 12 KW - Index Medicus KW - Occupational Exposure KW - Radiation Dosage KW - Age Factors KW - Sex Factors KW - Humans KW - Risk Assessment KW - Lymphoma -- mortality KW - Lymphoma -- epidemiology KW - Leukemia -- mortality KW - Leukemia -- epidemiology KW - Multiple Myeloma -- epidemiology KW - Adult KW - Cohort Studies KW - Incidence KW - Middle Aged KW - United States -- epidemiology KW - Time Factors KW - Multiple Myeloma -- mortality KW - Female KW - Male KW - Proportional Hazards Models KW - Personnel, Hospital KW - Neoplasms, Radiation-Induced -- epidemiology KW - Technology, Radiologic -- manpower KW - Neoplasms, Radiation-Induced -- mortality KW - Hematologic Neoplasms -- epidemiology KW - Hematologic Neoplasms -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68819095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+environmental+medicine&rft.atitle=Incidence+of+haematopoietic+malignancies+in+US+radiologic+technologists.&rft.au=Linet%2C+M+S%3BFreedman%2C+D+M%3BMohan%2C+A+K%3BDoody%2C+M+M%3BRon%2C+E%3BMabuchi%2C+K%3BAlexander%2C+B+H%3BSigurdson%2C+A%3BHauptmann%2C+M&rft.aulast=Linet&rft.aufirst=M&rft.date=2005-12-01&rft.volume=62&rft.issue=12&rft.spage=861&rft.isbn=&rft.btitle=&rft.title=Occupational+and+environmental+medicine&rft.issn=1470-7926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-03 N1 - Date created - 2005-11-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Radiol Prot. 2000 Dec;20(4):353-9 [11140709] Nucleonics. 1949 Dec;5(6):63-6 [15394470] Health Phys. 2002 Apr;82(4):455-66 [11906134] Int J Cancer. 2003 Jan 10;103(2):259-67 [12455042] Semin Ultrasound CT MR. 2002 Oct;23(5):428-42 [12509113] Am J Epidemiol. 1975 Mar;101(3):199-210 [1115059] Radiology. 1978 Mar;126(3):677-9 [628739] Br J Radiol. 1981 Mar;54(639):187-94 [7470779] JAMA. 1990 Aug 1;264(5):601-4 [2366300] Br J Radiol. 1991 May;64(761):455-60 [2036572] Cancer. 1992 Jan 15;69(2):586-98 [1728391] Radiat Res. 1995 Apr;142(1):1-11 [7899552] Radiat Res. 1995 May;142(2):117-32 [7724726] Radiat Res. 1995 Nov;144(2):160-9 [7480642] Am J Epidemiol. 1997 Jan 1;145(1):72-80 [8982025] J Radiol Prot. 1999 Mar;19(1):3-26 [10321692] J Epidemiol. 1999 Apr;9(2):61-72 [10337078] Radiat Res. 1999 Sep;152(3):280-92 [10453089] Radiology. 1953 Feb;60(2):186-91 [13112398] Am J Roentgenol Radium Ther Nucl Med. 1957 Dec;78(6):988-92 [13478785] Science. 1963 Dec 13;142(3598):1492-4 [14077037] Br J Radiol. 2001 Jun;74(882):507-19 [11459730] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Epidural fentanyl speeds the onset of sensory and motor blocks during epidural ropivacaine anesthesia. AN - 68816252; 16301269 AB - In this study we examined the onset times of sensory and motor block during epidural ropivacaine anesthesia with and without the addition of fentanyl to the epidural solution. Forty-five young male patients undergoing knee arthroscopic surgery were randomly allocated into 3 groups of 15 patients each: epidural fentanyl (EF; epidural administration of 15 mL of 1% ropivacaine plus 100 mug fentanyl followed by IV injection of 2 mL of normal saline); IV fentanyl (IF; epidural administration of 15 mL of 1% ropivacaine plus 2 mL of normal saline followed by IV injection of 100 mug fentanyl); and control (C; epidural administration of 15 mL of 1% ropivacaine plus 2 mL of normal saline followed by IV injection of 2 mL of normal saline). The sensory and motor blocks were assessed by pinprick and modified Bromage scale, respectively. The hemodynamic changes, postepidural shivering, and side effects of epidural fentanyl were also recorded. There was no difference in the distribution of age, weight, and height among the 3 groups. The onset time of sensory block to the T10 dermatome was significantly more rapid in the EF group (13.0 +/- 3.0 min) than in the IF group (16.2 +/- 3.5 min, P < 0.05) or C group (17.7 +/- 3.6 min, P < 0.05). The onset times of motor block up to Bromage scale 1 and 2 were significantly more rapid in the EF group (11.9 +/- 4.6 and 24.4 +/- 5.9 min) than in the IF group (16.9 +/- 4.7 and 30.8 +/- 5.6 min, P < 0.05) or C group (18.3 +/- 4.9 and 32.7 +/- 5.7 min, P < 0.05). There was no difference in the incidence of shivering among the three groups. Pruritus was observed in three patients of the EF group and one patient of the IF group. No nausea, vomiting, respiratory depression, urinary retention, or hypotension was observed in any patient. We conclude that epidural administration of the mixture of 100 mug fentanyl and 1% ropivacaine solution accelerated the onset of sensory and motor blocks during epidural ropivacaine anesthesia without significant fentanyl-related side effects. JF - Anesthesia and analgesia AU - Cherng, Chen-Hwan AU - Yang, Chih-Ping AU - Wong, Chih-Shung AD - Department of Anesthesiology, Tri-Service General Hospital, No. 325, Sec. 2, Cheng-Gung Road, Nei-Hu, 114, Taipei, Taiwan. cherng1018@yahoo.com.tw Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1834 EP - 1837 VL - 101 IS - 6 SN - 0003-2999, 0003-2999 KW - Amides KW - 0 KW - Analgesics, Opioid KW - Anesthetics, Local KW - ropivacaine KW - 7IO5LYA57N KW - Fentanyl KW - UF599785JZ KW - Abridged Index Medicus KW - Index Medicus KW - Prospective Studies KW - Arthroscopy KW - Double-Blind Method KW - Humans KW - Adult KW - Drug Synergism KW - Sensation KW - Knee -- surgery KW - Amides -- pharmacology KW - Anesthetics, Local -- pharmacology KW - Analgesics, Opioid -- pharmacology KW - Fentanyl -- pharmacology KW - Anesthesia, Epidural -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68816252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesia+and+analgesia&rft.atitle=Epidural+fentanyl+speeds+the+onset+of+sensory+and+motor+blocks+during+epidural+ropivacaine+anesthesia.&rft.au=Cherng%2C+Chen-Hwan%3BYang%2C+Chih-Ping%3BWong%2C+Chih-Shung&rft.aulast=Cherng&rft.aufirst=Chen-Hwan&rft.date=2005-12-01&rft.volume=101&rft.issue=6&rft.spage=1834&rft.isbn=&rft.btitle=&rft.title=Anesthesia+and+analgesia&rft.issn=00032999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-20 N1 - Date created - 2005-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Brain hyperthermia as physiological and pathological phenomena. AN - 68807323; 15890410 AB - Although brain metabolism consumes high amounts of energy and is accompanied by intense heat production, brain temperature is usually considered a stable, tightly "regulated" homeostatic parameter. Current research, however, revealed relatively large and rapid brain temperature fluctuations (3-4 degrees C) in animals during various normal, physiological, and behavioral activities at stable ambient temperatures. This review discusses these data and demonstrates that physiological brain hyperthermia has an intra-brain origin, resulting from enhanced neural metabolism and increased intra-brain heat production. Therefore, brain temperature is an important physiological parameter that both reflects alterations in metabolic neural activity and affects various neural functions. This work also shows that brain hyperthermia may be induced by various drugs of abuse that cause metabolic brain activation and impair heat dissipation. While individual drugs (i.e., heroin, cocaine, methamphetamine, MDMA) have specific, dose-dependent effects on brain and body temperatures, these effects are strongly modulated by an individual's activity state and environmental conditions, and change dramatically during the development of drug self-administration. Thus, brain thermorecording may provide new information on the central effects of various addictive drugs, drug-activity-environment interactions in mediating drugs' adverse effects, and alterations in metabolic neural activity associated with the development of drug-seeking and drug-taking behavior. While ambient temperatures and impairment of heat dissipation may also affect brain temperature, these environmental conditions strongly potentiate thermal effects of psychomotor stimulant drugs, resulting in pathological brain overheating. Since hyperthermia exacerbates drug-induced toxicity and is destructive to neural cells and brain functions, use of these drugs under activated conditions that restrict heat loss may pose a significant health risk, resulting in both acute life-threatening complications and chronic destructive CNS changes. JF - Brain research. Brain research reviews AU - Kiyatkin, Eugene A AD - Cellular Neurobiology Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, DHHS, 5500 Nathan Shock, Baltimore, MD 21224, USA. ekiyatki@intra.nida.nih.gov Y1 - 2005/12/01/ PY - 2005 DA - 2005 Dec 01 SP - 27 EP - 56 VL - 50 IS - 1 KW - Adrenergic Uptake Inhibitors KW - 0 KW - Narcotics KW - Index Medicus KW - Animals KW - Adrenergic Uptake Inhibitors -- adverse effects KW - Humans KW - Narcotics -- adverse effects KW - Body Temperature -- physiology KW - Fever -- pathology KW - Brain Diseases -- chemically induced KW - Fever -- physiopathology KW - Brain Diseases -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68807323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research.+Brain+research+reviews&rft.atitle=Brain+hyperthermia+as+physiological+and+pathological+phenomena.&rft.au=Kiyatkin%2C+Eugene+A&rft.aulast=Kiyatkin&rft.aufirst=Eugene&rft.date=2005-12-01&rft.volume=50&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Brain+research.+Brain+research+reviews&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-30 N1 - Date created - 2005-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Molecular mechanisms of hexavalent chromium-induced apoptosis in human bronchoalveolar cells. AN - 68806698; 16166740 AB - Hexavalent chromium (Cr[VI]) is classified by the International Agency for Research on Cancer as a group I carcinogen. Although the U.S. Occupational Safety and Health Administration was obliged to reduce the permissible exposure limit (PEL), it was reported that U.S. workers continue to be exposed to dangerously high Cr(VI) levels. In this study, we examined the role of p53 and target genes in a bronchoalveolar carcinoma isogenic cell line system and in primary human bronchial epithelial cells. p53-Negative parental H358 cell line, the same line in which the wild-type p53 expression vector (pC53-SN3) was introduced, and cells obtained from biopsies of human bronchus were exposed to chromate. Induction of DNA strand breaks were evaluated by alkaline elution assay, and apoptosis was analyzed by gel ladder, annexin V-PI staining, and ELISA, whereas p53 and target genes were evaluated by Western blots. Although Cr(VI) induced DNA strand breaks in both H358 cell clones, apoptosis was present only in the p53-transfected cells (H358p53(+/+)). In these cells, Cr(VI)-induced apoptosis is mediated by p53 upregulation of p53-upregulated modulator of apoptosis (PUMA), BAX translocation to mitochondria, cytochrome c release, and caspase-3 activation. In primary human bronchial epithelial cells expressing functional p53, Cr(VI) induced expression of PUMA and Noxa, which promote apoptosis through BAX. This result establishes p53 as the "necessary" player in Cr(VI)-induced apoptosis. To the best of our knowledge, this is the first report indicating strict correlation of Cr(VI) apoptosis to PUMA induction on primary human bronchoalveolar cells in short-term cultures. JF - American journal of respiratory cell and molecular biology AU - Russo, Patrizia AU - Catassi, Alessia AU - Cesario, Alfredo AU - Imperatori, Andrea AU - Rotolo, Nicola AU - Fini, Massimo AU - Granone, Pierluigi AU - Dominioni, Lorenzo AD - Department of Integrated Medical Oncology (DOMI), Laboratory of Translational Research B (Lung Cancer), National Cancer Institute, Largo Rosanna Benzi 10, I-16132 Genoa, Italy. patrizia.russo@istge.it Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 589 EP - 600 VL - 33 IS - 6 SN - 1044-1549, 1044-1549 KW - Apoptosis Regulatory Proteins KW - 0 KW - BBC3 protein, human KW - Carcinogens, Environmental KW - Proto-Oncogene Proteins KW - Tumor Suppressor Protein p53 KW - bcl-2-Associated X Protein KW - Chromium KW - 0R0008Q3JB KW - chromium hexavalent ion KW - 18540-29-9 KW - Cytochromes c KW - 9007-43-6 KW - CASP3 protein, human KW - EC 3.4.22.- KW - Caspase 3 KW - Caspases KW - Index Medicus KW - Cytochromes c -- metabolism KW - Humans KW - Biopsy KW - Bronchi -- drug effects KW - Caspases -- metabolism KW - bcl-2-Associated X Protein -- metabolism KW - DNA Damage -- drug effects KW - Epithelial Cells -- metabolism KW - Epithelial Cells -- drug effects KW - Tumor Cells, Cultured KW - Bronchi -- cytology KW - Mitochondria -- drug effects KW - Enzyme Activation -- drug effects KW - Mitochondria -- metabolism KW - Enzyme-Linked Immunosorbent Assay KW - Up-Regulation KW - Bronchi -- metabolism KW - Protein Transport KW - Adenocarcinoma, Bronchiolo-Alveolar -- drug therapy KW - Lung Neoplasms -- drug therapy KW - Apoptosis Regulatory Proteins -- metabolism KW - Apoptosis -- drug effects KW - Proto-Oncogene Proteins -- metabolism KW - Adenocarcinoma, Bronchiolo-Alveolar -- metabolism KW - Carcinogens, Environmental -- toxicity KW - Chromium -- toxicity KW - Tumor Suppressor Protein p53 -- metabolism KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68806698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=Molecular+mechanisms+of+hexavalent+chromium-induced+apoptosis+in+human+bronchoalveolar+cells.&rft.au=Russo%2C+Patrizia%3BCatassi%2C+Alessia%3BCesario%2C+Alfredo%3BImperatori%2C+Andrea%3BRotolo%2C+Nicola%3BFini%2C+Massimo%3BGranone%2C+Pierluigi%3BDominioni%2C+Lorenzo&rft.aulast=Russo&rft.aufirst=Patrizia&rft.date=2005-12-01&rft.volume=33&rft.issue=6&rft.spage=589&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+cell+and+molecular+biology&rft.issn=10441549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-11-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Biophys Res Commun. 2000 Apr 2;270(1):303-10 [10733944] Cancer. 2005 Apr 1;103(7):1503-18 [15700263] Am J Ind Med. 2000 Aug;38(2):115-26 [10893504] Carcinogenesis. 2001 May;22(5):757-62 [11323395] Am J Respir Cell Mol Biol. 2001 Jun;24(6):703-10 [11415935] Mol Cell. 2001 Mar;7(3):673-82 [11463391] Mol Cell. 2001 Mar;7(3):683-94 [11463392] Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11318-23 [11572983] Hum Exp Toxicol. 2001 Sep;20(9):439-51 [11776406] Int J Cancer. 2002 Feb 20;97(6):732-9 [11857347] Mol Carcinog. 2002 Mar;33(3):172-80 [11870883] Carcinogenesis. 2002 Apr;23(4):587-93 [11960910] Am J Ind Med. 2002 Nov;42(5):378-83 [12382250] J Pharmacol Exp Ther. 2003 Jan;304(1):37-47 [12490573] Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1931-6 [12574499] Occup Environ Med. 2003 Jun;60(6):451-7 [12771398] J Thorac Cardiovasc Surg. 2003 Jun;125(6):1321-7 [12830051] Mutat Res. 2003 Dec 10;533(1-2):3-36 [14643411] Cancer Res. 2004 Jan 1;64(1):135-45 [14729617] Am J Ind Med. 2004 Mar;45(3):308-9; author reply 310 [14991859] Oncogene. 2004 Apr 12;23(16):2934-49 [15077155] Mol Cell Biol. 2004 Aug;24(15):6728-41 [15254240] Neoplasma. 2004;51(3):175-80 [15254669] Br J Cancer. 2004 Aug;91 Suppl 2:S31-7 [15340376] Mutat Res. 2004 Oct 4;554(1-2):241-51 [15450422] J Biol Chem. 1977 Sep 25;252(18):6438-42 [893418] Eur J Biochem. 1981 Mar 16;115(1):207-16 [7227366] Cancer Res. 1983 Dec;43(12 Pt 1):5662-7 [6640521] Cancer Res. 1985 Jul;45(7):3179-87 [4005851] Sci Total Environ. 1988 Jun 1;71(3):331-9 [3043655] Am J Ind Med. 1990;17(2):189-215 [2405656] Mutat Res. 1990 Mar;238(2):99-172 [2407950] IARC Monogr Eval Carcinog Risks Hum. 1990;49:1-648 [2232124] Mutat Res. 1993 Apr;299(2):95-102 [7680428] Chest. 1994 Mar;105(3 Suppl):67S-74S [8131616] J Biol Chem. 1995 Jan 27;270(4):1894-8 [7829527] Am J Pathol. 1996 Sep;149(3):845-52 [8780388] Annu Rev Biochem. 1996;65:43-81 [8811174] Crit Rev Toxicol. 1997 Sep;27(5):431-42 [9347224] Nucleic Acids Res. 1998 Apr 15;26(8):2024-30 [9518499] Mol Carcinog. 1998 Dec;23(4):201-6 [9869448] Biochemistry. 2004 Nov 9;43(44):14282-9 [15518579] Cancer Res. 2004 Dec 15;64(24):9217-24 [15604295] J Pathol. 2005 Jan;205(2):221-35 [15643669] Nat Rev Cancer. 2005 Mar;5(3):231-7 [15738985] Toxicol Sci. 2000 May;55(1):60-8 [10788560] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells. AN - 68805980; 16109773 AB - Retroviruses can induce hematopoietic disease via insertional mutagenesis of cancer genes and provide valuable molecular tags for cancer gene discovery. Here we show that insertional mutagenesis can also identify genes that promote the immortalization of hematopoietic cells, which normally have only limited self-renewal. Transduction of mouse bone marrow cells with replication-incompetent murine stem cell virus (MSCV) expressing only neo, followed by serial passage in liquid culture containing stem cell factor (SCF) and interleukin-3 (IL-3), produced immortalized immature myeloid cell lines with neutrophil and macrophage differentiation potential in about 50% of the infected cultures. More than half of the lines have MSCV insertions at Evi1 or Prdm16. These loci encode transcription factor homologs and are validated human myeloid leukemia genes. Integrations are located in intron 1 or 2, where they promote expression of truncated proteins lacking the PRDI-BF1-RIZ1 homologous (PR) domain, similar to what is observed in human leukemias with EVI1 or PRDM16 mutations. Evi1 overexpression alone appears sufficient to immortalize immature myeloid cells and does not seem to require any other cooperating mutations. Genes identified by insertional mutagenesis by their nature could also be involved in immortalization of leukemic stem cells, and thus represent attractive drug targets for treating cancer. JF - Blood AU - Du, Yang AU - Jenkins, Nancy A AU - Copeland, Neal G AD - Mouse Cancer Genetics Program, National Cancer Institute, Center for Cancer Research, Frederick, MD 21702, USA. Y1 - 2005/12/01/ PY - 2005 DA - 2005 Dec 01 SP - 3932 EP - 3939 VL - 106 IS - 12 SN - 0006-4971, 0006-4971 KW - DNA-Binding Proteins KW - 0 KW - MECOM protein, human KW - PRDM16 protein, human KW - Transcription Factors KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Blotting, Northern KW - Humans KW - Transduction, Genetic KW - DNA-Binding Proteins -- genetics KW - Cell Differentiation KW - Mice KW - Transcription Factors -- genetics KW - Leukemia -- genetics KW - Polymerase Chain Reaction KW - Blotting, Southern KW - Zinc Fingers -- genetics KW - Proto-Oncogenes -- genetics KW - Cell Culture Techniques -- methods KW - Flow Cytometry KW - Retroviridae -- genetics KW - Bone Marrow Cells -- virology KW - Hematopoietic Stem Cells -- physiology KW - Hematopoietic Stem Cells -- virology KW - Cell Line, Transformed KW - Mutagenesis, Insertional -- genetics KW - Bone Marrow Cells -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68805980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Insertional+mutagenesis+identifies+genes+that+promote+the+immortalization+of+primary+bone+marrow+progenitor+cells.&rft.au=Du%2C+Yang%3BJenkins%2C+Nancy+A%3BCopeland%2C+Neal+G&rft.aulast=Du&rft.aufirst=Yang&rft.date=2005-12-01&rft.volume=106&rft.issue=12&rft.spage=3932&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-18 N1 - Date created - 2005-11-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Blood. 2000 Feb 1;95(3):1007-13 [10648416] Cell. 2000 Jan 7;100(1):57-70 [10647931] Mol Cell Biol. 2000 Oct;20(20):7419-26 [11003639] Blood. 2000 Nov 1;96(9):3209-14 [11050005] Nat Med. 2000 Nov;6(11):1278-81 [11062542] J Exp Med. 2001 Feb 19;193(4):531-43 [11181704] Genesis. 2001 Jun;30(2):82-8 [11416868] Nature. 2001 Nov 1;414(6859):105-11 [11689955] Haematologica. 2001 Nov;86(11):1124-57 [11694400] Acta Haematol. 2002;107(2):76-94 [11919388] Science. 2002 Apr 19;296(5567):497 [11964471] Mol Cell. 2002 Nov;10(5):1107-17 [12453418] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8 [12629218] Nature. 2003 May 15;423(6937):255-60 [12714970] Nature. 2003 May 15;423(6937):302-5 [12714971] Nat Immunol. 2003 Jun;4(6):525-32 [12717432] Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10002-7 [12890867] Blood Cells Mol Dis. 2003 Sep-Oct;31(2):206-12 [12972028] Blood. 2003 Nov 1;102(9):3323-32 [12816872] Haematologica. 2003 Nov;88(11):1221-8 [14607750] J Biol Chem. 2003 Dec 12;278(50):49806-11 [14555651] Genes Dev. 2003 Dec 15;17(24):3029-35 [14701873] Cancer Sci. 2004 Jun;95(6):503-7 [15182431] N Engl J Med. 2004 Aug 12;351(7):657-67 [15306667] J Clin Invest. 2004 Sep;114(5):713-9 [15343390] Blood. 1985 Dec;66(6):1362-70 [4063525] Blood. 1986 Sep;68(3):652-7 [3461853] Proc Natl Acad Sci U S A. 1990 Dec;87(23):9202-6 [2251265] Mol Cell Biol. 1992 Jan;12(1):183-9 [1370341] Proc Natl Acad Sci U S A. 1992 May 1;89(9):3937-41 [1570317] J Exp Med. 1992 Oct 1;176(4):1149-63 [1402659] Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6454-8 [8341654] Leukemia. 1993 Oct;7(10):1654-7 [8412328] Blood. 1994 Oct 15;84(8):2681-8 [7919381] Leukemia. 1996 May;10(5):788-94 [8656673] J Exp Med. 1996 May 1;183(5):2283-91 [8642337] Genomics. 1996 Oct 1;37(1):24-8 [8921366] Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14059-64 [8943060] Genes Dev. 1997 Jan 15;11(2):226-40 [9009205] Nat Med. 1997 Jul;3(7):730-7 [9212098] J Biol Chem. 1998 Jun 26;273(26):15933-9 [9632640] Blood. 1998 Jul 1;92(1):83-92 [9639503] Immunity. 1998 Jul;9(1):47-57 [9697835] Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10129-33 [9707612] Haematologica. 1999 Aug;84(8):690-4 [10457403] Cancer Cell. 2004 Dec;6(6):587-96 [15607963] Blood. 2005 Oct 1;106(7):2530-3 [15933056] Nature. 1994 Feb 17;367(6464):645-8 [7509044] Blood. 1994 Aug 15;84(4):1243-8 [8049440] Genes Dev. 1999 Oct 15;13(20):2678-90 [10541554] Leukemia. 1999 Nov;13(11):1639-45 [10557037] Histol Histopathol. 2000 Jan;15(1):109-17 [10668202] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Combined blockade of AMPA and NMDA glutamate receptors reduces levodopa-induced motor complications in animal models of PD. AN - 68805518; 16203001 AB - AMPA and NMDA receptors, abundantly expressed on striatal medium spiny neurons, have been implicated in the regulation of corticostriatal synaptic efficacy. To evaluate the contribution of both glutamate receptor types to the pathogenesis of motor response alterations associated with dopaminergic treatment, we studied the ability of the selective AMPA receptor antagonist GYKI-47261 and the selective NMDA receptor antagonists, MK-801 and amantadine, to mitigate these syndromes in rodent and primate models of Parkinson's disease. The effects of GYKI-47261 and amantadine (or MK-801), alone and in combination, were compared for their ability to modify dyskinesias induced by levodopa. In rats, simultaneous administration of subthreshold doses of AMPA and NMDA receptor antagonists completely normalized the wearing-off response to acute levodopa challenge produced by chronic levodopa treatment (P < 0.05). In primates, the glutamate antagonists GYKI-47261 and amantadine, co-administered at low doses (failing to alter dyskinesia scores), reduced levodopa-induced dyskinesias by 51% (P < 0.05). The simultaneous AMPA and NMDA receptor blockade acts to provide a substantially greater reduction in the response alterations induced by levodopa than inhibition of either of these receptors alone. The results suggest that mechanisms mediated by both ionotropic glutamate receptors make an independent contribution to the pathogenesis of these motor response changes and further that a combination of both drug types may provide relief from these disabling complications at lower and thus safer and more tolerable doses than required when either drug is used alone. JF - Experimental neurology AU - Bibbiani, F AU - Oh, J D AU - Kielaite, A AU - Collins, M A AU - Smith, C AU - Chase, T N AD - ETB, NINDS, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 422 EP - 429 VL - 196 IS - 2 SN - 0014-4886, 0014-4886 KW - Antiparkinson Agents KW - 0 KW - Benzazepines KW - Dopamine Agents KW - Dopamine Agonists KW - Excitatory Amino Acid Antagonists KW - GYKI 47261 KW - Receptors, AMPA KW - Receptors, Glutamate KW - Receptors, N-Methyl-D-Aspartate KW - Benzodiazepines KW - 12794-10-4 KW - Quinpirole KW - 20OP60125T KW - Levodopa KW - 46627O600J KW - Dizocilpine Maleate KW - 6LR8C1B66Q KW - SK&F 82958 KW - 80751-65-1 KW - Amantadine KW - BF4C9Z1J53 KW - Index Medicus KW - Rotarod Performance Test -- methods KW - Animals KW - Benzazepines -- pharmacology KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Receptors, Glutamate -- physiology KW - Disease Models, Animal KW - Haplorhini KW - Behavior, Animal KW - Dizocilpine Maleate -- pharmacology KW - Excitatory Amino Acid Antagonists -- pharmacology KW - Rats KW - Rats, Sprague-Dawley KW - Quinpirole -- pharmacology KW - Dopamine Agonists -- pharmacology KW - Motor Activity -- drug effects KW - Antiparkinson Agents -- pharmacology KW - Amantadine -- pharmacology KW - Benzodiazepines -- pharmacology KW - Time Factors KW - Male KW - Parkinson Disease, Secondary -- chemically induced KW - Receptors, N-Methyl-D-Aspartate -- physiology KW - Receptors, AMPA -- antagonists & inhibitors KW - Receptors, N-Methyl-D-Aspartate -- antagonists & inhibitors KW - Receptors, AMPA -- physiology KW - Dopamine Agents -- adverse effects KW - Levodopa -- adverse effects KW - Parkinson Disease, Secondary -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68805518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+neurology&rft.atitle=Combined+blockade+of+AMPA+and+NMDA+glutamate+receptors+reduces+levodopa-induced+motor+complications+in+animal+models+of+PD.&rft.au=Bibbiani%2C+F%3BOh%2C+J+D%3BKielaite%2C+A%3BCollins%2C+M+A%3BSmith%2C+C%3BChase%2C+T+N&rft.aulast=Bibbiani&rft.aufirst=F&rft.date=2005-12-01&rft.volume=196&rft.issue=2&rft.spage=422&rft.isbn=&rft.btitle=&rft.title=Experimental+neurology&rft.issn=00144886&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-25 N1 - Date created - 2005-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Functional characterization of novel allelic variants of CYP2C9 recently discovered in southeast Asians. AN - 68801576; 16099926 AB - CYP2C9 was recently resequenced in 150 Asian subjects from Singapore. Several new coding variants were reported, and these variants are now named CYP2C9*14 (R125H), CYP2C9*15 (S162X), CYP2C9*16 (T299A), CYP2C9*17 (P382S), CYP2C9*18 (D397A), and CYP2C9*19 (Q454H). The CYP2C9*18 variant also contained an I359L change previously associated with the CYP2C9*3 allele. In this study, we assessed the functional consequences of the new coding changes. cDNAs containing each of the new coding changes were constructed by site-directed mutagenesis and expressed in a bacterial cDNA expression system, the allelic proteins were partially purified, and their ability to hydroxylate a prototype CYP2C9 substrate was assayed. Expression of cDNAs in Escherichia coli containing either the D397A change or the S162X (premature stop codon) could not be detected either spectrally or at the apoprotein level. CYP2C9.14 and CYP2C9.16 exhibited 80 to 90% lower catalytic activity toward tolbutamide at two substrate concentrations compared with wild-type CYP2C9.1. Kinetic analysis confirmed that CYP2C9.14 and CYP2C9.16 have a higher Km and a >90% lower intrinsic clearance of tolbutamide compared with wild-type CYP2C9.1. Both CYP2C9.17 and CYP2C9.19 proteins exhibited modest 30 to 40% decreases in catalytic activity toward tolbutamide. Thus, CYP2C9*15 and CYP2C9*18 may represent null alleles, whereas CYP2C9*14 and CYP2C9*16 allelic variants produce proteins that are clearly catalytically defective in vitro, indicating the existence of new defective putative alleles of CYP2C9 in Asians. JF - The Journal of pharmacology and experimental therapeutics AU - DeLozier, Tracy C AU - Lee, Soo-Chin AU - Coulter, Sherry J AU - Goh, Boon Cher AU - Goldstein, Joyce A AD - Human Metabolism Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1085 EP - 1090 VL - 315 IS - 3 SN - 0022-3565, 0022-3565 KW - DNA, Complementary KW - 0 KW - Recombinant Proteins KW - Tolbutamide KW - 982XCM1FOI KW - CYP2C9 protein, human KW - EC 1.14.13.- KW - Cytochrome P-450 CYP2C9 KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - Index Medicus KW - India -- ethnology KW - Humans KW - Tolbutamide -- pharmacology KW - Tolbutamide -- pharmacokinetics KW - Escherichia coli -- genetics KW - Hydroxylation KW - Mutagenesis, Site-Directed KW - Recombinant Proteins -- isolation & purification KW - Tolbutamide -- metabolism KW - Recombinant Proteins -- metabolism KW - Kinetics KW - Singapore KW - China -- ethnology KW - Catalysis KW - Genetic Variation KW - Polymorphism, Single Nucleotide KW - Aryl Hydrocarbon Hydroxylases -- metabolism KW - Alleles KW - Aryl Hydrocarbon Hydroxylases -- genetics KW - Aryl Hydrocarbon Hydroxylases -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68801576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Functional+characterization+of+novel+allelic+variants+of+CYP2C9+recently+discovered+in+southeast+Asians.&rft.au=DeLozier%2C+Tracy+C%3BLee%2C+Soo-Chin%3BCoulter%2C+Sherry+J%3BGoh%2C+Boon+Cher%3BGoldstein%2C+Joyce+A&rft.aulast=DeLozier&rft.aufirst=Tracy&rft.date=2005-12-01&rft.volume=315&rft.issue=3&rft.spage=1085&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-23 N1 - Date created - 2005-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tau is hyperphosphorylated in the insulin-like growth factor-I null brain. AN - 68799875; 16123158 AB - IGF action has been implicated in the promotion of oxidative stress and aging in invertebrate and murine models. However, some in vitro models suggest that IGF-I specifically prevents neuronal oxidative damage. To investigate whether IGF-I promotes or retards brain aging, we evaluated signs of oxidative stress and neuropathological aging in brains from 400-d-old Igf1-/- and wild-type (WT) mice. Lipofuscin pigment accumulation reflects oxidative stress and aging, but we found no difference in lipofuscin deposition in Igf1-/- and WT brains. Likewise, there was no apparent difference in accumulation of nitrotyrosine residues in Igf1-/- and WT brains, except for layer IV/V of the cerebral cortex, where these proteins were about 20% higher in the Igf1-/- brain (P = 0.03). We found no difference in the levels of oxidative stress-related enzymes, neuronal nitric oxide synthase, inducible nitric oxide synthase, and superoxide dismutase in Igf1-/- and WT brains. Tau is a microtubule-associated protein that causes the formation of neurofibrillary tangles and senile plaques as it becomes hyperphosphorylated in the aging brain. Tau phosphorylation was dramatically increased on two specific residues, Ser-396 and Ser-202, both glycogen synthase kinases target sites implicated in neurodegeneration. These observations indicate that IGF-I has a major role in regulating tau phosphorylation in the aging brain, whereas its role in promoting or preventing oxidative stress remains uncertain. JF - Endocrinology AU - Cheng, Clara M AU - Tseng, Victor AU - Wang, Jie AU - Wang, Daniel AU - Matyakhina, Ludmila AU - Bondy, Carolyn A AD - Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. chengc@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 5086 EP - 5091 VL - 146 IS - 12 SN - 0013-7227, 0013-7227 KW - Lipofuscin KW - 0 KW - tau Proteins KW - 3-nitrotyrosine KW - 3604-79-3 KW - Tyrosine KW - 42HK56048U KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Aging -- metabolism KW - Phosphorylation KW - Oxidative Stress KW - Drug Residues -- metabolism KW - Mice KW - Tyrosine -- metabolism KW - Tyrosine -- analogs & derivatives KW - Male KW - Lipofuscin -- metabolism KW - Nitric Oxide Synthase -- biosynthesis KW - Mice, Knockout KW - Brain -- enzymology KW - tau Proteins -- metabolism KW - Insulin-Like Growth Factor I -- deficiency KW - Brain -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68799875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+International+Meeting+on+Tumor+Progression+and+Therapeutic+Resistance+%28TPTR+2005%29&rft.atitle=Biomarkers+and+Imaging+Endpoints+to+Accelerate+Oncologic+Drug+Development&rft.au=Kelloff%2C+Gary&rft.aulast=Kelloff&rft.aufirst=Gary&rft.date=2005-09-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+International+Meeting+on+Tumor+Progression+and+Therapeutic+Resistance+%28TPTR+2005%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-05 N1 - Date created - 2005-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Assessment of the integrity of study blindness in a pediatric clinical trial of risperidone. AN - 68797858; 16282839 AB - Controlled clinical trials in pediatric psychopharmacology rely on blinded parents and clinical evaluators for outcome data, but little is known about the success of the masking procedures. The blindness of clinical evaluators and parents was examined in a clinical trial of risperidone in autism. Clinical evaluators and parents were asked to guess individual treatment assignments at the end of an 8-week placebo-controlled trial of risperidone in children (aged 5-17 years) with autism. Clinical evaluators did not have access to adverse event data. The rates of correctly guessing individual treatment assignment (risperidone or placebo) were significantly greater than chance for both clinical evaluators and parents (P < 0.001). Clinical evaluators associated improvement with attribution to risperidone, and lack of improvement with attribution to placebo, in both the risperidone and placebo treatment arms. Parents associated improvement with attribution to risperidone only in the placebo treatment arm. Parents reported that adverse events influenced their guesses, but presence of adverse events was not associated with correctness of guess. Improvement was associated with attribution to active treatment regardless of actual treatment assignment, and adverse events did not appear to be a threat to study blindness. JF - Journal of clinical psychopharmacology AU - Vitiello, Benedetto AU - Davies, Mark AU - Arnold, L Eugene AU - McDougle, Christopher J AU - Aman, Michael AU - McCracken, James T AU - Scahill, Lawrence AU - Tierney, Elaine AU - Posey, David J AU - Swiezy, Naomi B AU - Koenig, Kathleen AD - Division of Services and Intervention Research, National Institute of Mental Health, Bethesda, MD 20892-9633, USA. bvitiell@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 565 EP - 569 VL - 25 IS - 6 SN - 0271-0749, 0271-0749 KW - Antipsychotic Agents KW - 0 KW - Risperidone KW - L6UH7ZF8HC KW - Index Medicus KW - Reproducibility of Results KW - Humans KW - Treatment Outcome KW - Child KW - Adolescent KW - Child, Preschool KW - Research Personnel -- psychology KW - Double-Blind Method KW - Antipsychotic Agents -- therapeutic use KW - Autistic Disorder -- drug therapy KW - Risperidone -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Risperidone -- therapeutic use KW - Parents -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68797858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychopharmacology&rft.atitle=Assessment+of+the+integrity+of+study+blindness+in+a+pediatric+clinical+trial+of+risperidone.&rft.au=Vitiello%2C+Benedetto%3BDavies%2C+Mark%3BArnold%2C+L+Eugene%3BMcDougle%2C+Christopher+J%3BAman%2C+Michael%3BMcCracken%2C+James+T%3BScahill%2C+Lawrence%3BTierney%2C+Elaine%3BPosey%2C+David+J%3BSwiezy%2C+Naomi+B%3BKoenig%2C+Kathleen&rft.aulast=Vitiello&rft.aufirst=Benedetto&rft.date=2005-12-01&rft.volume=25&rft.issue=6&rft.spage=565&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychopharmacology&rft.issn=02710749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-28 N1 - Date created - 2005-11-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Specific recognition and cleavage of the plus-strand primer by reverse transcriptase. AN - 68794383; 16282486 AB - Reverse transcriptases (RTs) of retroviruses and long terminal repeat (LTR)-retrotransposons possess DNA polymerase and RNase H activities. During reverse transcription these activities are necessary for the programmed sequence of events that include template switching and primer processing. Integrase then inserts the completed cDNA into the genome of the host cell. The RT of the LTR-retrotransposon Tf1 was subjected to random mutagenesis, and the resulting transposons were screened with genetic assays to test which mutations reduced reverse transcription and which inhibited integration. We identified a cluster of mutations in the RNase H domain of RT that were surprising because they blocked integration without reducing cDNA levels. The results of immunoblots demonstrated that these mutations did not reduce levels of RT or integrase. DNA blots showed that the mutations did not lower the amounts of full-length cDNA. The sequences of the 3' ends of the cDNA revealed that mutations within the cluster in RNase H specifically reduced the removal of the polypurine tract (PPT) primer from the ends of the cDNA. These results indicate that primer removal is not a necessary component of reverse transcription. The residues mutated in Tf1 RNase H are conserved in human immunodeficiency virus type 1 and make direct contact with DNA opposite the PPT. Thus, our results identify a conserved element in RT that contacts the PPT and is specifically required for PPT removal. JF - Journal of virology AU - Atwood-Moore, Angela AU - Ejebe, Kenechi AU - Levin, Henry L AD - Section on Eukaryotic Transposable Elements, Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 14863 EP - 14875 VL - 79 IS - 23 SN - 0022-538X, 0022-538X KW - DNA, Viral KW - 0 KW - RNA primers KW - RNA KW - 63231-63-0 KW - HIV Reverse Transcriptase KW - EC 2.7.7.49 KW - RNA-Directed DNA Polymerase KW - Ribonuclease H KW - EC 3.1.26.4 KW - Index Medicus KW - Saccharomyces cerevisiae -- genetics KW - HIV Long Terminal Repeat KW - DNA, Viral -- biosynthesis KW - Saccharomyces cerevisiae -- metabolism KW - HIV Reverse Transcriptase -- metabolism KW - Templates, Genetic KW - Substrate Specificity KW - RNA -- metabolism KW - RNA-Directed DNA Polymerase -- chemistry KW - RNA -- chemistry KW - RNA-Directed DNA Polymerase -- metabolism KW - Ribonuclease H -- metabolism KW - RNA-Directed DNA Polymerase -- genetics KW - RNA -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68794383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Specific+recognition+and+cleavage+of+the+plus-strand+primer+by+reverse+transcriptase.&rft.au=Atwood-Moore%2C+Angela%3BEjebe%2C+Kenechi%3BLevin%2C+Henry+L&rft.aulast=Atwood-Moore&rft.aufirst=Angela&rft.date=2005-12-01&rft.volume=79&rft.issue=23&rft.spage=14863&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-23 N1 - Date created - 2005-11-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 2000 May;74(10):4755-64 [10775614] J Virol. 1999 Jun;73(6):5186-90 [10233986] Biochemistry. 2002 Apr 16;41(15):4856-65 [11939780] J Biol Chem. 2002 May 10;277(19):16689-96 [11875059] Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9515-20 [12093908] J Virol. 2002 Aug;76(16):8360-73 [12134040] J Mol Biol. 2003 Dec 5;334(4):653-65 [14636594] Int J Biochem Cell Biol. 2004 Sep;36(9):1752-66 [15183342] Cell. 1990 Aug 24;62(4):829-37 [2167180] Cell. 1990 Oct 5;63(1):87-95 [2170022] EMBO J. 1990 Oct;9(10):3353-62 [1698615] Mol Cell Biol. 1990 Dec;10(12):6791-8 [2174117] Methods Enzymol. 1991;194:795-823 [2005825] J Virol. 1991 Sep;65(9):4636-44 [1870194] J Virol. 1992 Apr;66(4):2359-68 [1548767] Science. 1992 Nov 13;258(5085):1112-8 [1279806] EMBO J. 1993 Dec;12(12):4885-95 [8223497] Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):549-53 [7507249] Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9847-51 [7937903] Virology. 1994 Dec;205(2):470-8 [7975248] Mol Cell Biol. 1995 Jun;15(6):3310-7 [7760826] Mol Cell Biol. 1996 Jan;16(1):338-46 [8524313] Mol Cell Biol. 1996 Oct;16(10):5645-54 [8816477] Genes Dev. 1997 Jan 15;11(2):270-85 [9009208] J Mol Biol. 1997 Jun 6;269(2):225-39 [9191067] J Virol. 1998 Feb;72(2):1324-33 [9445033] Mol Cell Biol. 1998 Feb;18(2):1094-104 [9448007] J Virol. 1998 Aug;72(8):6490-503 [9658092] J Virol. 1998 Nov;72(11):9318-22 [9765482] Mol Cell Biol. 1998 Nov;18(11):6839-52 [9774697] EMBO J. 2001 Mar 15;20(6):1449-61 [11250910] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of CYP2E1 in the epoxidation of acrylamide to glycidamide and formation of DNA and hemoglobin adducts. AN - 68794284; 16141435 AB - Acrylamide (AA) is an animal carcinogen, neurotoxin, and reproductive toxin. AA is formed in baked and fried carbohydrate-rich foods. Metabolism of AA occurs via epoxidation to glycidamide (GA) or direct conjugation with glutathione. Using CYP2E1-null mice, recent studies in this laboratory demonstrated that induction of somatic and germ cell mutagenicity in AA-treated mice is dependent on CYP2E1. We hypothesized that AA metabolism to GA is a prerequisite for the induction of AA-induced mutagenicity. Current studies were undertaken to assess the role of CYP2E1 in the epoxidation of AA to GA and the formation of DNA and hemoglobin (HGB) adducts. AA was administered to CYP2E1-null or wild-type mice at 50 mg/kg ip. Mice were euthanized 6 h later and blood and tissues were collected. Using LC-ES/MS/MS, AA, GA, and DNA- and HGB-adducts were measured. While the plasma levels of AA and GA were 115 +/- 14.0 and 1.7 +/- 0.31 microM in CYP2E1-null mice, they were 0.84 +/- 0.80 and 33.0 +/- 6.3 microM in the plasma of AA-treated wild-type mice. Administration of AA to wild-type mice caused a large increase in N7-GA-Gua and N3-GA-Ade adducts in the liver, lung, and testes. While traces of N7-GA-Gua adducts were measured in the tissues of AA-treated CYP2E1-null mice, these levels were 52- to 66-fold lower than in wild-type mice. Significant elevation of both AA- and GA-HGB adducts was detected in AA-treated wild-type mice. In AA-treated CYP2E1-null mice, levels of AA-HGB adducts were roughly twice as high as those in wild-type mice. In conclusion, current work demonstrated that CYP2E1 is the primary enzyme responsible for the epoxidation of AA to GA, which leads to the formation of GA-DNA and HGB adducts. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Ghanayem, Burhan I AU - McDaniel, L Patrice AU - Churchwell, Mona I AU - Twaddle, Nathan C AU - Snyder, Rodney AU - Fennell, Timothy R AU - Doerge, Daniel R AD - Laboratory of Pharmacology and Chemistry, National Toxicology Program, NIEHS/NIH, Research Triangle Park, NC 27709, USA. ghanayem@niehs.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 311 EP - 318 VL - 88 IS - 2 SN - 1096-6080, 1096-6080 KW - DNA Adducts KW - 0 KW - Epoxy Compounds KW - Hemoglobins KW - Acrylamide KW - 20R035KLCI KW - glycidamide KW - 6G5ELX5XYN KW - DNA KW - 9007-49-2 KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - Index Medicus KW - Animals KW - Liver -- enzymology KW - Lung -- chemistry KW - Mice KW - Liver -- chemistry KW - DNA -- drug effects KW - Mice, Knockout KW - Testis -- drug effects KW - Liver -- drug effects KW - Lung -- drug effects KW - Mice, Inbred C57BL KW - Testis -- enzymology KW - Lung -- enzymology KW - Testis -- chemistry KW - Male KW - Hemoglobins -- metabolism KW - DNA Adducts -- chemistry KW - Cytochrome P-450 CYP2E1 -- deficiency KW - Epoxy Compounds -- metabolism KW - Epoxy Compounds -- chemistry KW - Acrylamide -- metabolism KW - Cytochrome P-450 CYP2E1 -- metabolism KW - Hemoglobins -- chemistry KW - Cytochrome P-450 CYP2E1 -- genetics KW - Acrylamide -- toxicity KW - DNA Adducts -- metabolism KW - Acrylamide -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68794284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Role+of+CYP2E1+in+the+epoxidation+of+acrylamide+to+glycidamide+and+formation+of+DNA+and+hemoglobin+adducts.&rft.au=Ghanayem%2C+Burhan+I%3BMcDaniel%2C+L+Patrice%3BChurchwell%2C+Mona+I%3BTwaddle%2C+Nathan+C%3BSnyder%2C+Rodney%3BFennell%2C+Timothy+R%3BDoerge%2C+Daniel+R&rft.aulast=Ghanayem&rft.aufirst=Burhan&rft.date=2005-12-01&rft.volume=88&rft.issue=2&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chemical effects in biological systems--data dictionary (CEBS-DD): a compendium of terms for the capture and integration of biological study design description, conventional phenotypes, and 'omics data. AN - 68792840; 16150882 AB - A critical component in the design of the Chemical Effects in Biological Systems (CEBS) Knowledgebase is a strategy to capture toxicogenomics study protocols and the toxicity endpoint data (clinical pathology and histopathology). A Study is generally an experiment carried out during a period of time for the purpose of obtaining data, and the Study Design Description captures the methods, timing, and organization of the Study. The CEBS Data Dictionary (CEBS-DD) has been designed to define and organize terms in an attempt to standardize nomenclature needed to describe a toxicogenomics Study in a structured yet intuitive format and provide a flexible means to describe a Study as conceptualized by the investigator. The CEBS-DD will organize and annotate information from a variety of sources, thereby facilitating the capture and display of toxicogenomics data in biological context in CEBS, i.e., associating molecular events detected in highly-parallel data with the toxicology/pathology phenotype as observed in the individual Study Subjects and linked to the experimental treatments. The CEBS-DD has been developed with a focus on acute toxicity studies, but with a design that will permit it to be extended to other areas of toxicology and biology with the addition of domain-specific terms. To illustrate the utility of the CEBS-DD, we present an example of integrating data from two proteomics and transcriptomics studies of the response to acute acetaminophen toxicity (A. N. Heinloth et al., 2004, Toxicol. Sci. 80, 193-202). JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Fostel, Jennifer AU - Choi, Danielle AU - Zwickl, Craig AU - Morrison, Norman AU - Rashid, Asif AU - Hasan, Atif AU - Bao, Wenjun AU - Richard, Ann AU - Tong, Weida AU - Bushel, Pierre R AU - Brown, Roger AU - Bruno, Maribel AU - Cunningham, Michael L AU - Dix, David AU - Eastin, William AU - Frade, Carlos AU - Garcia, Alex AU - Heinloth, Alexandra AU - Irwin, Rick AU - Madenspacher, Jennifer AU - Merrick, B Alex AU - Papoian, Thomas AU - Paules, Richard AU - Rocca-Serra, Philippe AU - Sansone, Assunta-Susanna AU - Stevens, James AU - Tomer, Kenneth AU - Yang, Chihae AU - Waters, Michael AD - LIMT Lockheed Martin Information Technology (LMIT), Research Triangle Park, NC 27709, USA. fostel@niehs.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 585 EP - 601 VL - 88 IS - 2 SN - 1096-6080, 1096-6080 KW - Acetaminophen KW - 362O9ITL9D KW - Index Medicus KW - Administration, Oral KW - Animals KW - Dose-Response Relationship, Drug KW - Proteomics KW - Toxicity Tests KW - Toxicogenetics KW - Acetaminophen -- toxicity KW - Biomedical Research KW - Systems Biology -- methods KW - Databases, Factual KW - Terminology as Topic KW - Research Design KW - Database Management Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68792840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Chemical+effects+in+biological+systems--data+dictionary+%28CEBS-DD%29%3A+a+compendium+of+terms+for+the+capture+and+integration+of+biological+study+design+description%2C+conventional+phenotypes%2C+and+%27omics+data.&rft.au=Fostel%2C+Jennifer%3BChoi%2C+Danielle%3BZwickl%2C+Craig%3BMorrison%2C+Norman%3BRashid%2C+Asif%3BHasan%2C+Atif%3BBao%2C+Wenjun%3BRichard%2C+Ann%3BTong%2C+Weida%3BBushel%2C+Pierre+R%3BBrown%2C+Roger%3BBruno%2C+Maribel%3BCunningham%2C+Michael+L%3BDix%2C+David%3BEastin%2C+William%3BFrade%2C+Carlos%3BGarcia%2C+Alex%3BHeinloth%2C+Alexandra%3BIrwin%2C+Rick%3BMadenspacher%2C+Jennifer%3BMerrick%2C+B+Alex%3BPapoian%2C+Thomas%3BPaules%2C+Richard%3BRocca-Serra%2C+Philippe%3BSansone%2C+Assunta-Susanna%3BStevens%2C+James%3BTomer%2C+Kenneth%3BYang%2C+Chihae%3BWaters%2C+Michael&rft.aulast=Fostel&rft.aufirst=Jennifer&rft.date=2005-12-01&rft.volume=88&rft.issue=2&rft.spage=585&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Research strategies for safety evaluation of nanomaterials, Part III: nanoscale technologies for assessing risk and improving public health. AN - 68787783; 16162851 AB - Risk assessment in the environmental health sciences focuses on understanding the nature of environmental exposures and the potential harm posed by those exposures which in turn is determined by the perturbation of biological pathways and the individual's susceptibility to damage. While there are extensive research efforts ongoing in these areas, progress in each is currently slowed by technological limitations including comprehensive assessment of multiple exposures in real time and dynamic assessment of biological response with high temporal and quantitative resolution. This Forum article discusses recent technological innovations capitalizing on the emergent properties of nanoscale materials and their potential adaptation to improving individual exposure assessment, determination of biological response, and environmental remediation. The ultimate goal is to raise the environmental health science community's awareness of these possibilities and encourage the development of improved strategies for assessing risk and improving public health. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Balshaw, David M AU - Philbert, Martin AU - Suk, William A AD - Center for Risk and Integrated Sciences, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Balshaw@niehs.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 298 EP - 306 VL - 88 IS - 2 SN - 1096-6080, 1096-6080 KW - Environmental Pollutants KW - 0 KW - Index Medicus KW - Biomedical Research KW - Humans KW - Public Health KW - Environmental Pollutants -- toxicity KW - Risk Assessment -- methods KW - Environmental Monitoring -- methods KW - Environmental Health -- methods KW - Nanotechnology KW - Environmental Monitoring -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68787783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Research+strategies+for+safety+evaluation+of+nanomaterials%2C+Part+III%3A+nanoscale+technologies+for+assessing+risk+and+improving+public+health.&rft.au=Balshaw%2C+David+M%3BPhilbert%2C+Martin%3BSuk%2C+William+A&rft.aulast=Balshaw&rft.aufirst=David&rft.date=2005-12-01&rft.volume=88&rft.issue=2&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Telomeres, telomerase and oral cancer (Review). AN - 68772503; 16273215 AB - Oral squamous cell carcinoma (oral cancer) and many squamous cell carcinomas of the head and neck arise as a consequence of multiple molecular events induced by the effects of various carcinogens related to tobacco use, environmental factors, and viruses in some instances (e.g., mucosal oncogenic human papillomaviruses), against a background of inheritable resistance or susceptibility. Consequent genetic damage affects many chromosomes and genes, and it is the accumulation of these changes that appears to lead to carcinoma. Telomere maintenance by telomerase or, in its absence, alternative lengthening of telomeres protect this acquired altered genetic information ensuring immortality without losing eukaryotic linear DNA; when this does not occur DNA is lost and end-replication problems arise. Telomerase is reactivated in 80-90% of cancers thus attracting the attention of pathologists and clinicians who have explored its use as a target for anticancer therapy and to develop better diagnostic and prognostic markers. In the last few years, valuable research from various laboratories has provided major insights into telomerase and telomeres leading to their use as diagnostic and prognostic markers in several types of cancer. Moreover, many strategies have emerged which inhibit this complex enzyme for anticancer therapy and are one step ahead of clinical trials. This review explains the basic biology and the clinical implications of telomerase-based diagnosis and prognosis, the prospects for its use in anticancer therapy, and the limitations it presents in the context of oral cancer. JF - International journal of oncology AU - Sebastian, Sinto AU - Grammatica, Luciano AU - Paradiso, Angelo AD - Clinical Experimental Oncology Laboratory, Surgery Department, National Cancer Institute, 70126 Bari, Italy. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1583 EP - 1596 VL - 27 IS - 6 SN - 1019-6439, 1019-6439 KW - Telomerase KW - EC 2.7.7.49 KW - Index Medicus KW - Humans KW - Prognosis KW - Models, Biological KW - Mouth Neoplasms -- therapy KW - Telomere -- genetics KW - Mouth Neoplasms -- enzymology KW - Telomerase -- metabolism KW - Mouth Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68772503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+oncology&rft.atitle=Telomeres%2C+telomerase+and+oral+cancer+%28Review%29.&rft.au=Sebastian%2C+Sinto%3BGrammatica%2C+Luciano%3BParadiso%2C+Angelo&rft.aulast=Sebastian&rft.aufirst=Sinto&rft.date=2005-12-01&rft.volume=27&rft.issue=6&rft.spage=1583&rft.isbn=&rft.btitle=&rft.title=International+journal+of+oncology&rft.issn=10196439&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-03 N1 - Date created - 2005-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Thoracic radiation therapy and concomitant low-dose daily paclitaxel in non-small cell lung cancer: a phase I study. AN - 68770255; 16273271 AB - The primary objective of the current study was to determine the maximum tolerated dose of paclitaxel (PTX) that could be added daily to radiation therapy (RT) in patients with non-small cell lung cancer (NSCLC). The secondary objective was to achieve a plasma concentration of PTX estimated to exert a radiosensitizing effect. Eighteen patients with locally advanced NSCLC were treated. 60 Gy of RT were given in 2 Gy fractions, 5 days per week. A daily dose of PTX was delivered by 4-h i.v. infusion before RT. The initial dose level of PTX was 9 mg/m2/day, escalated by 1 mg at each additional patient triplet. Two out of 6 patients experienced acute dose limiting toxicity (DLT) at the 12 mg/m2/day PTX dose level. PTX continuously greater than 10 nM, the estimated radiosensitizing condition, was achieved at the PTX dose level of 12 mg/m2/day. PTX at doses up to 11 mg/m2/day may be safely added to a conventional conformal RT course. Both DLT and the estimated radiosensitizing plasma exposure to PTX were encountered at the 12 mg/m(2)/day dose level. JF - Oncology reports AU - Gobitti, Carlo AU - Franchin, Giovanni AU - Minatel, Emilio AU - Gigante, Marco AU - Basso, Barbara AU - Bujor, Laurentiu AU - Trovò, Mauro G AD - Radiation Oncology Department, Centro di Riferimento Oncologico, National Cancer Institute, 33081 Aviano, Italy. cgobitti@cro.it Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1647 EP - 1653 VL - 14 IS - 6 SN - 1021-335X, 1021-335X KW - Antineoplastic Agents, Phytogenic KW - 0 KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Area Under Curve KW - Infusions, Intravenous KW - Combined Modality Therapy KW - Dose-Response Relationship, Drug KW - Humans KW - Antineoplastic Agents, Phytogenic -- blood KW - Aged KW - Chromatography, High Pressure Liquid KW - Radiotherapy Dosage KW - Antineoplastic Agents, Phytogenic -- therapeutic use KW - Treatment Outcome KW - Middle Aged KW - Antineoplastic Agents, Phytogenic -- administration & dosage KW - Female KW - Male KW - Survival Analysis KW - Paclitaxel -- administration & dosage KW - Lung Neoplasms -- radiotherapy KW - Paclitaxel -- pharmacokinetics KW - Lung Neoplasms -- drug therapy KW - Paclitaxel -- therapeutic use KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Lung Neoplasms -- pathology KW - Carcinoma, Non-Small-Cell Lung -- radiotherapy KW - Carcinoma, Non-Small-Cell Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68770255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology+reports&rft.atitle=Thoracic+radiation+therapy+and+concomitant+low-dose+daily+paclitaxel+in+non-small+cell+lung+cancer%3A+a+phase+I+study.&rft.au=Gobitti%2C+Carlo%3BFranchin%2C+Giovanni%3BMinatel%2C+Emilio%3BGigante%2C+Marco%3BBasso%2C+Barbara%3BBujor%2C+Laurentiu%3BTrov%C3%B2%2C+Mauro+G&rft.aulast=Gobitti&rft.aufirst=Carlo&rft.date=2005-12-01&rft.volume=14&rft.issue=6&rft.spage=1647&rft.isbn=&rft.btitle=&rft.title=Oncology+reports&rft.issn=1021335X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-09 N1 - Date created - 2005-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nitric oxide regulates prolidase activity by serine/threonine phosphorylation. AN - 68766098; 16167338 AB - Prolidase [E.C. 3.4.13.9], a member of the matrix metalloproteinase (MMP) family, is a manganese-dependent cytosolic exopeptidase that cleaves imidodipeptides containing C-terminal proline or hydroxyproline. It plays an important role in collagen metabolism, matrix remodeling and cell growth. Nitric oxide (NO), a versatile signaling molecule, regulates many processes including collagen synthesis and matrix remodeling and, thereby, may modulate angiogenesis, tumor invasiveness, and metastasis. Thus, we considered that prolidase may be an important target of NO regulation. In our study, SIN I and DETA/NO were used as NO donors. Both donors increased prolidase activity in a time-dependent and dose-dependent manner. Prolidase activity increased not only with NO donors but also with endogenous NO in cells transfected with iNOS. The effect of iNOS was abolished by treatment with S-methylisothiourea (SMT), a selective inhibitor of iNOS. However, with either exogenous or endogenous sources of NO, the increase in prolidase activity was not accompanied by increased prolidase expression. Therefore, we suspected phosphorylation of prolidase as a potential mechanism regulating enzyme activation. We observed increased serine/threonine phosphorylation on prolidase protein in cells treated with NO donors and in cells transfected with iNOS. To determinate the pathways that may mediate prolidase induction by NO, we first used 8-Br-cGMP, a cGMP agonist, and found that 8-Br-cGMP strongly and rapidly stimulated prolidase activity accompanied by increased phosphorylation. Rp-8-Br-pCPT-cGMP, an inhibitor of cGMP, reduced NO donor-stimulated prolidase activity to control levels. To test whether the MAPK pathway is involved in this NO-dependent activation, we used an ERK1/2 inhibitor and found that it had no effect on prolidase activity increased by NO donors. These results demonstrate that NO stimulates prolidase activity by increasing serine/threonine phosphorylation through PKG-cGMP pathway, but independent of MAPK and suggest an interaction between inflammatory signaling pathways and regulation of the terminal step of matrix degradation. 2005 Wiley-Liss, Inc. JF - Journal of cellular biochemistry AU - Surazynski, Arkadiusz AU - Liu, Yongmin AU - Miltyk, Wojciech AU - Phang, James M AD - Metabolism and Cancer Susceptibility Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. Y1 - 2005/12/01/ PY - 2005 DA - 2005 Dec 01 SP - 1086 EP - 1094 VL - 96 IS - 5 SN - 0730-2312, 0730-2312 KW - DNA, Complementary KW - 0 KW - Peptides KW - Threonine KW - 2ZD004190S KW - Nitric Oxide KW - 31C4KY9ESH KW - Serine KW - 452VLY9402 KW - Nitric Oxide Synthase Type II KW - EC 1.14.13.39 KW - Mitogen-Activated Protein Kinase 1 KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinase 3 KW - Dipeptidases KW - EC 3.4.13.- KW - proline dipeptidase KW - EC 3.4.13.9 KW - Matrix Metalloproteinases KW - EC 3.4.24.- KW - Thiourea KW - GYV9AM2QAG KW - Cyclic GMP KW - H2D2X058MU KW - Index Medicus KW - Animals KW - Plasmids -- metabolism KW - Dose-Response Relationship, Drug KW - Wound Healing KW - Immunoprecipitation KW - Mice KW - NIH 3T3 Cells KW - Inflammation KW - Mitogen-Activated Protein Kinase 3 -- metabolism KW - Blotting, Western KW - Cyclic GMP -- metabolism KW - Phosphorylation KW - Transfection KW - Matrix Metalloproteinases -- chemistry KW - DNA, Complementary -- metabolism KW - Mitogen-Activated Protein Kinase 1 -- metabolism KW - Peptides -- chemistry KW - Nitric Oxide Synthase Type II -- metabolism KW - Neovascularization, Pathologic KW - Thiourea -- chemistry KW - Time Factors KW - Signal Transduction KW - Dipeptidases -- biosynthesis KW - Threonine -- chemistry KW - Gene Expression Regulation, Enzymologic KW - Nitric Oxide -- metabolism KW - Dipeptidases -- chemistry KW - Serine -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68766098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=9th+International+Workshop+on+Langerhans+Cells+%28LC+2005%29&rft.atitle=Induction+of+a+Graft-Versus-Host-Like+Skin+Disease+by+Intradermal+Injection+of+Ovalbumin-Peptide-Specific+CD8%2B+%28OT-I%29+T+Cells+into+Keratin+14-Ovalbumin-Expressing+Transgenic+Mice&rft.au=Kim%2C+B+S%3BMiyagawa%2C+F%3BKatz%2C+S+I&rft.aulast=Kim&rft.aufirst=B&rft.date=2005-09-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=9th+International+Workshop+on+Langerhans+Cells+%28LC+2005%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-20 N1 - Date created - 2005-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), in rats and dogs: potential clinical relevance. AN - 68658649; 15986212 AB - 17-DMAG is a hydrophilic derivative of the molecular chaperone inhibitor 17-(allylamino)-17-demethoxygeldanamycin (17-AAG; NSC-330507), which is currently being evaluated for the treatment of cancer in clinical trials. 17-DMAG offers a potential advantage over 17-AAG because its aqueous solubility eliminates the need for complicated formulations that are currently used for administration of 17-AAG. In addition, 17-DMAG undergoes only limited metabolism compared to 17-AAG. The present results are from preclinical toxicity studies evaluating 17-DMAG in rats and dogs. Doses of 0, 2.4, 12 and 24 mg/m2 per day were administered to rats, while dogs received doses of 0, 8 or 16 mg/m2 per day. In both species, 17-DMAG was administered i.v. (slow bolus for rats; 1-h infusion for dogs) daily for 5 days. An additional cohort of dogs received 16 mg/m2 per day orally for 5 days. Clinical observations were noted, and standard hematology and clinical chemistry parameters were monitored. Selected tissues were evaluated microscopically for drug-related lesions. Tissue and plasma 17-DMAG concentrations were measured by HPLC/MS at selected time-points on days 1 and 5. Daily i.v. administration of 17-DMAG at doses of 24 mg/m2 per day in rats or 16 mg/m2 per day in dogs produced lethality on day 6, approximately 24 h following the last dose. Body weight loss was common in rats and dogs. Drug-related gastrointestinal, bone marrow and hepatic toxicities were also common in rats and dogs. Dogs also exhibited signs of renal and gallbladder toxicity. Plasma concentrations of 17-DMAG increased proportionately with dose in rats and disproportionately with dose in dogs. In rat tissues, however, only fourfold to sixfold increases in 17-DMAG concentrations were observed with a tenfold increase in dose. The highest concentrations of 17-DMAG were found in the liver of rats, with progressively lower concentrations in the spleen, lung, kidney and plasma. Regardless of the route of administration, higher drug concentrations were present in plasma (rat and dog) and tissue (rat) samples obtained on day 5 compared to those obtained on day 1. Although plasma concentrations decreased with time, 17-DMAG was still detected in dog plasma for at least 24 h after drug administration. With the recent approval of 17-DMAG for clinical use, the data generated from these preclinical studies will provide guidance to clinicians as they administer this drug to their patients. The MTD of 17-DMAG was 12 mg/m2 per day in rats and 8 mg/m2 per day in dogs; therefore, the recommended starting dose for phase I trial is 1.3 mg/m2 per day for 5 days. Gastrointestinal and bone marrow toxicity were dose-limiting in rats, and gastrointestinal, renal, gallbladder and bone marrow toxicity were dose-limiting in dogs. All adverse effects were fully reversible in surviving animals after treatment was complete. JF - Cancer chemotherapy and pharmacology AU - Glaze, Elizabeth R AU - Lambert, Amy L AU - Smith, Adaline C AU - Page, John G AU - Johnson, William D AU - McCormick, David L AU - Brown, Alan P AU - Levine, Barry S AU - Covey, Joseph M AU - Egorin, Merrill J AU - Eiseman, Julie L AU - Holleran, Julianne L AU - Sausville, Edward A AU - Tomaszewski, Joseph E AD - Toxicology and Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Executive Plaza North, Room 8040, Rockville, MD 20852, USA. glazee@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 637 EP - 647 VL - 56 IS - 6 SN - 0344-5704, 0344-5704 KW - Antibiotics, Antineoplastic KW - 0 KW - Benzoquinones KW - Lactams, Macrocyclic KW - Quinones KW - 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin KW - 001L2FE0M3 KW - geldanamycin KW - Z3K3VJ16KU KW - Index Medicus KW - Animals KW - Recovery of Function KW - Rats KW - Rats, Inbred F344 KW - Gastrointestinal Tract -- drug effects KW - Clinical Chemistry Tests KW - Bone Marrow -- drug effects KW - Male KW - Administration, Oral KW - Bone Marrow -- pathology KW - Kidney -- pathology KW - Infusions, Intravenous KW - Injections, Intravenous KW - Dose-Response Relationship, Drug KW - Longevity -- drug effects KW - Kidney -- drug effects KW - Gallbladder -- drug effects KW - Hematologic Tests KW - Gastrointestinal Tract -- pathology KW - Body Weight -- drug effects KW - Toxicity Tests KW - Dogs KW - Species Specificity KW - Gallbladder -- pathology KW - Female KW - Quinones -- pharmacokinetics KW - Quinones -- toxicity KW - Antibiotics, Antineoplastic -- pharmacokinetics KW - Antibiotics, Antineoplastic -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68658649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=Preclinical+toxicity+of+a+geldanamycin+analog%2C+17-%28dimethylaminoethylamino%29-17-demethoxygeldanamycin+%2817-DMAG%29%2C+in+rats+and+dogs%3A+potential+clinical+relevance.&rft.au=Glaze%2C+Elizabeth+R%3BLambert%2C+Amy+L%3BSmith%2C+Adaline+C%3BPage%2C+John+G%3BJohnson%2C+William+D%3BMcCormick%2C+David+L%3BBrown%2C+Alan+P%3BLevine%2C+Barry+S%3BCovey%2C+Joseph+M%3BEgorin%2C+Merrill+J%3BEiseman%2C+Julie+L%3BHolleran%2C+Julianne+L%3BSausville%2C+Edward+A%3BTomaszewski%2C+Joseph+E&rft.aulast=Glaze&rft.aufirst=Elizabeth&rft.date=2005-12-01&rft.volume=56&rft.issue=6&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=03445704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-05 N1 - Date created - 2005-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Homozygous germ line mutation in exon 27 of murine Brca2 disrupts the Fancd2-Brca2 pathway in the homologous recombination-mediated DNA interstrand cross-links' repair but does not affect meiosis. AN - 68642130; 16127665 AB - The role of the region encoded by exon 27 of the Brca2 gene in DNA repair was studied in cells and tissues from Brca2Delta27/Delta27 mice. The COOH-terminal truncated Brca2 localized to the nucleus in primary mouse embryo fibroblasts from Brca2Delta27/Delta27 mice. Fluorescence-activated cell sorting (FACS) analysis demonstrated that these fibroblasts were hypersensitive to mitomycin C-induced cross-links, but not to double-strand breaks (DSBs) induced by irradiation. The gammaH2AX appearance kinetics and comet assay showed that DSBs were repaired through non-homologous end joining pathways, while interstrand cross-links were not repaired due to deficient homologous recombination pathways. Immunoprecipitation experiments showed that Fancd2 did not coprecipitate with the mutated Brca2. There were also no detectable Rad51-positive foci formed in these cells after damage. On the other hand, we did not find any difference during gametogenesis in mice harboring exon 27 truncating mutation of the Brca2 gene and control mice, and in both cases, Rad51 localized to the recombination foci. Our results suggest that exon 27 of murine Brca2 is crucial for the interaction of Brca2 and Fancd2 in Rad51-mediated recombination in response to DNA damage, but that this interaction is not taking place in the homologous recombination during meiosis. Published 2005 Wiley-Liss, Inc. JF - Genes, chromosomes & cancer AU - Atanassov, Boyko S AU - Barrett, J Carl AU - Davis, Barbara J AD - Laboratory of Women's Health, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 429 EP - 437 VL - 44 IS - 4 SN - 1045-2257, 1045-2257 KW - BRCA2 Protein KW - 0 KW - Fanconi Anemia Complementation Group D2 Protein KW - Histones KW - gamma-H2AX protein, mouse KW - Mitomycin KW - 50SG953SK6 KW - Rad51 Recombinase KW - EC 2.7.7.- KW - Rad51 protein, mouse KW - Index Medicus KW - Animals KW - Comet Assay KW - Fibroblasts -- drug effects KW - Cell Nucleus -- metabolism KW - Exons KW - Fluorescent Antibody Technique, Indirect KW - Mitomycin -- pharmacology KW - Mice KW - Rad51 Recombinase -- metabolism KW - Blotting, Western KW - Cells, Cultured KW - Kinetics KW - Histones -- metabolism KW - Fibroblasts -- radiation effects KW - Flow Cytometry KW - Embryo, Mammalian KW - Female KW - Radiation, Ionizing KW - DNA Repair KW - BRCA2 Protein -- chemistry KW - Meiosis KW - Recombination, Genetic KW - Fanconi Anemia Complementation Group D2 Protein -- metabolism KW - BRCA2 Protein -- metabolism KW - Germ-Line Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68642130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genes%2C+chromosomes+%26+cancer&rft.atitle=Homozygous+germ+line+mutation+in+exon+27+of+murine+Brca2+disrupts+the+Fancd2-Brca2+pathway+in+the+homologous+recombination-mediated+DNA+interstrand+cross-links%27+repair+but+does+not+affect+meiosis.&rft.au=Atanassov%2C+Boyko+S%3BBarrett%2C+J+Carl%3BDavis%2C+Barbara+J&rft.aulast=Atanassov&rft.aufirst=Boyko&rft.date=2005-12-01&rft.volume=44&rft.issue=4&rft.spage=429&rft.isbn=&rft.btitle=&rft.title=Genes%2C+chromosomes+%26+cancer&rft.issn=10452257&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-06 N1 - Date created - 2005-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Modulation of cytochrome P450 enzymes by organosulfur compounds from garlic. AN - 68622945; 16000231 AB - Organosulfur compounds (OSCs) derived from garlic have been studied for the ability to inhibit experimental cancer in various animal models, primarily through modification of carcinogen detoxification enzymes, such as cytochrome P450 (CYP) enzymes. OSCs vary in structural and physical properties, and a detailed analysis of these properties has not been performed with respect to their ability of inhibit chemically-induced colon cancer development. Gastric intubation of rats with a single dose of 200 mg/kg diallyl sulfide (DAS), diallyl disulfide (DADS), and allyl methyl sulfide (AMS) decreased hepatic CYP2E1 protein by 45%, 25% and 47%, respectively, and this inhibition was sustained after 1, 4 and 8 weeks of treatment by these compounds. Dipropyl sulfide (DPS), dipropyl disulfide (DPDS), propyl methyl sulfide (PMS) and S-allylcysteine (SAC) did not inhibit hepatic CYP2E1 protein expression, nor did any of the OSCs affect CYP2E1 mRNA levels. A single dose of 200 mg/kg DAS and AMS increased hepatic CYP1A2 protein (but not mRNA) by 282% and 70%, and DAS increased CYP1A1 protein levels by 684%. Daily treatment for 1, 4 and 8 weeks with 200 mg/kg DAS and AMS resulted in time-dependent increases in hepatic CYP1A1 and CYP1A2 protein levels to a maximum of 600% and 50% for DAS, and 1600% and 240% for AMS after 8 weeks. Dosing with 200 mg/kg of each of the OSCs used in this study increased hepatic CYP3A2 protein levels at all time points. Dosing for 8 weeks with 200 mg/kg DAS, but not AMS or lower doses of DAS, induced bile duct obstruction and focal areas of necrosis. These results indicate that OSCs present in garlic, including DAS and AMS, may be beneficial in inhibiting chemically-induced colon cancer, but that longer dosing with higher concentrations of DAS may elicit minor hepatic toxicity. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Davenport, Destiny M AU - Wargovich, Michael J AD - Department of Pathology and Microbiology, University of South Carolina, School of Medicine and South Carolina Cancer Center, Columbia, SC 29208, USA. matthew2@niehs.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1753 EP - 1762 VL - 43 IS - 12 SN - 0278-6915, 0278-6915 KW - Allyl Compounds KW - 0 KW - Anticarcinogenic Agents KW - Disulfides KW - Sulfides KW - Sulfur Compounds KW - diallyl disulfide KW - 5HI47O6OA7 KW - allyl sulfide KW - 60G7CF7CWZ KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP1A2 KW - allyl methyl sulfide KW - V7QI1R316C KW - Index Medicus KW - Animals KW - Random Allocation KW - Dose-Response Relationship, Drug KW - Disulfides -- pharmacology KW - Cytochrome P-450 CYP1A2 -- metabolism KW - Allyl Compounds -- pharmacology KW - Cytochrome P-450 CYP1A1 -- metabolism KW - Cytochrome P-450 CYP2E1 -- metabolism KW - Allyl Compounds -- toxicity KW - Rats KW - Cytochrome P-450 CYP1A2 -- drug effects KW - Rats, Inbred F344 KW - Carcinogenicity Tests KW - Sulfides -- toxicity KW - Time Factors KW - Sulfides -- pharmacology KW - Cytochrome P-450 CYP2E1 -- drug effects KW - Male KW - Disulfides -- toxicity KW - Cytochrome P-450 CYP1A1 -- drug effects KW - Anticarcinogenic Agents -- toxicity KW - Liver -- pathology KW - Liver -- enzymology KW - Sulfur Compounds -- toxicity KW - Sulfur Compounds -- pharmacology KW - Liver -- drug effects KW - Anticarcinogenic Agents -- pharmacology KW - Cytochrome P-450 Enzyme System -- metabolism KW - Cytochrome P-450 Enzyme System -- drug effects KW - Garlic -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68622945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=22nd+Annual+Scientific+Meeting+of+the+European+Society+for+Magnetic+Resonance+in+Medicine+and+Biology+%28ESMRMB+2005%29&rft.atitle=Regional+Strain+Mapping+of+the+Carotid+Artery+Wall+in+Humans+Using+DENSE&rft.au=Wen%2C+H%3BVignaud%2C+A%3BRodriguez%2C+I&rft.aulast=Wen&rft.aufirst=H&rft.date=2005-09-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=22nd+Annual+Scientific+Meeting+of+the+European+Society+for+Magnetic+Resonance+in+Medicine+and+Biology+%28ESMRMB+2005%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-29 N1 - Date created - 2005-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Signal transduction during environmental stress: InsP8 operates within highly restricted contexts. AN - 68572328; 15936174 AB - Genetic manipulation of diphosphoinositol polyphosphate synthesis impacts many biological processes (reviewed in S.B. Shears, Biochem. J. 377, 2004, 265-280). These observations lacked a cell-signalling context, until the recent discovery that bis-diphosphoinositol tetrakisphosphate ([PP]2-InsP4 or "InsP8") accumulates rapidly in mammalian cells in response to hyperosmotic stress (X. Pesesse, K. Choi, T. Zhang, and S. B. Shears J. Biol. Chem. 279, 2004, 43378-43381). We now investigate how widely applicable is this new stress-response. [PP]2-InsP4 did not respond to mechanical strain or oxidative stress in mammalian cells. Furthermore, despite tight conservation of many molecular stress responses across the phylogenetic spectrum, we show that cellular [PP]2-InsP4 levels do not respond significantly to osmotic imbalance, heat stress and salt toxicity in Saccharomyces cerevisiae. In contrast, we show that [PP]2-InsP4 is a novel sensor of mild thermal stress in mammalian cells: [PP]2-InsP4 levels increased 3-4 fold when cells were cooled from 37 to 33 degrees C, or heated to 42 degrees C. Increases in [PP]2-InsP4 levels following heat-shock were evident <5 min, and reversible (t(1/2)=7 min) once cells were returned to 37 degrees C. These responses were blocked by pharmacological inhibition of the ERK/MEK pathway. Additional control processes may lie upstream of [PP]2-InsP4 synthesis, which was synergistically activated when heat stress and osmotic stress were combined. Our data add to the repertoire of signaling responses following thermal challenges, a topic of current interest for its possible therapeutic value. JF - Cellular signalling AU - Choi, Kuicheon AU - Mollapour, Elahe AU - Shears, Stephen B AD - Inositide Signaling Group, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, PO Box 12233, NC 27709, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1533 EP - 1541 VL - 17 IS - 12 SN - 0898-6568, 0898-6568 KW - Saccharomyces cerevisiae Proteins KW - 0 KW - p38 Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - MAP Kinase Kinase Kinases KW - EC 2.7.11.25 KW - Phosphotransferases (Phosphate Group Acceptor) KW - EC 2.7.4.- KW - KCS1 protein, S cerevisiae KW - EC 2.7.4.21 KW - Acid Anhydride Hydrolases KW - EC 3.6.- KW - diphosphoinositol polyphosphate phosphohydrolase KW - EC 3.6.1.- KW - Index Medicus KW - Saccharomyces cerevisiae Proteins -- metabolism KW - Animals KW - Osmotic Pressure KW - Saccharomyces cerevisiae Proteins -- genetics KW - Heat-Shock Response KW - Humans KW - Saccharomyces cerevisiae -- enzymology KW - Myocytes, Smooth Muscle -- metabolism KW - p38 Mitogen-Activated Protein Kinases -- metabolism KW - Saccharomyces cerevisiae -- genetics KW - MAP Kinase Kinase Kinases -- metabolism KW - MAP Kinase Kinase Kinases -- antagonists & inhibitors KW - p38 Mitogen-Activated Protein Kinases -- antagonists & inhibitors KW - Stress, Mechanical KW - Oxidative Stress KW - Phosphotransferases (Phosphate Group Acceptor) -- metabolism KW - Keratinocytes -- metabolism KW - Phosphotransferases (Phosphate Group Acceptor) -- genetics KW - Cell Line KW - Cricetinae KW - MAP Kinase Signaling System KW - Acid Anhydride Hydrolases -- metabolism KW - Signal Transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68572328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+signalling&rft.atitle=Signal+transduction+during+environmental+stress%3A+InsP8+operates+within+highly+restricted+contexts.&rft.au=Choi%2C+Kuicheon%3BMollapour%2C+Elahe%3BShears%2C+Stephen+B&rft.aulast=Choi&rft.aufirst=Kuicheon&rft.date=2005-12-01&rft.volume=17&rft.issue=12&rft.spage=1533&rft.isbn=&rft.btitle=&rft.title=Cellular+signalling&rft.issn=08986568&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-04 N1 - Date created - 2005-09-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Relationships between Childhood Sexual Abuse, Social Anxiety, and Symptoms of Posttraumatic Stress Disorder in Women AN - 60002281; 200614125 AB - The relationships between childhood sexual abuse, social anxiety, & symptoms of posttraumatic stress disorder were examined in a sample of 313 undergraduate women. Thirty-one percent of the women reported some form of sexual abuse in childhood. Women with a history of sexual abuse reported more symptoms of anxiety, distress in social situations, & posttraumatic stress disorder than other women. Women who experienced attempted or actual intercourse reported more avoidance than women with no history of abuse & women with exposure only, & more PTSD symptoms than all other groups of women. Women who experienced fondling reported more PTSD symptoms than women with no history of abuse. Pressure, age of onset of abuse, abuse by a family friend, & abuse by other perpetrators were all significant abuse characteristics in predicting adult social anxiety. Implications of these results for research & interventions are discussed. Tables, References. Adapted from the source document. JF - Journal of Family Violence AU - Feerick, Margaret M AU - Snow, Kyle L AD - National Instit Child Health & Human Development, National Instit Health, Bethesda, MD feerickm@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 409 EP - 419 PB - Springer Science+Business Media, Inc, New York, NY VL - 20 IS - 6 SN - 0885-7482, 0885-7482 KW - childhood sexual abuse KW - long-term effects KW - social anxiety KW - PTSD KW - Symptoms KW - Anxiety KW - Females KW - Posttraumatic Stress Disorder KW - Child Sexual Abuse KW - article KW - 2190: social problems and social welfare; victimology (rape, family violence, & child abuse) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60002281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Family+Violence&rft.atitle=The+Relationships+between+Childhood+Sexual+Abuse%2C+Social+Anxiety%2C+and+Symptoms+of+Posttraumatic+Stress+Disorder+in+Women&rft.au=Feerick%2C+Margaret+M%3BSnow%2C+Kyle+L&rft.aulast=Feerick&rft.aufirst=Margaret&rft.date=2005-12-01&rft.volume=20&rft.issue=6&rft.spage=409&rft.isbn=&rft.btitle=&rft.title=Journal+of+Family+Violence&rft.issn=08857482&rft_id=info:doi/10.1007%2Fs10896-005-7802-z LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Number of references - 81 N1 - Last updated - 2016-09-28 N1 - CODEN - JFVIEV N1 - SubjectsTermNotLitGenreText - Females; Child Sexual Abuse; Anxiety; Posttraumatic Stress Disorder; Symptoms DO - http://dx.doi.org/10.1007/s10896-005-7802-z ER - TY - JOUR T1 - Physician Migration: Views from Professionals in Colombia, Nigeria, India, Pakistan and the Philippines AN - 57185034; 200610160 AB - There has been much debate recently about several issues related to the migration of physicians from developing to developed countries. However, few studies have been conducted to address these issues in a systematic fashion. In an attempt to begin the process of generating systematic data, we designed & distributed a questionnaire addressing several core issues surrounding physician migration to respondents selected on the basis of their special expertise or experience in India, Nigeria, Pakistan, Colombia, & the Philippines. The issues addressed relate to the reasons physicians migrate to developed countries, how migration is related to the structure of medical education, the effect that migration has on the health care infrastructure of developing countries, & various policy options for dealing with physician migration. Though responses varied somewhat by country, a desire for increased income, greater access to enhanced technology, an atmosphere of general security & stability, & improved prospects for one's children were the primary motivating factors for physician migration. A majority of respondents believed that physicians in developing counties are provided with highly specialized skills that they can better utilize in developed countries, but respondents were ambivalent with respect to the utility of educational reform. Responses varied significantly by country with regard to whether physician migration results in physician shortages, but there was widespread agreement that it exacerbates shortages in rural & public settings. With respect to policy options, increasing physician income, improving working conditions, requiring physicians to work in their home countries for a period following graduation from medical school, & creating increased collaboration between health ministries in developed & developing countries found the most favor with respondents. 4 Tables, 27 References. [Copyright 2005 Elsevier Ltd.] JF - Social Science & Medicine AU - Astor, Avraham AU - Akhtar, Tasleem AU - Matallana, Maria Alexandra AU - Muthuswamy, Vasantha AU - Olowu, Folarin A AU - Tallo, Veronica AU - Lie, Reidar K AD - c/o Lie -- Dept Clinical Bioethics, National Instit Health, Bethesda, MD Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 2492 EP - 2500 PB - Elsevier Science, Amsterdam The Netherlands VL - 61 IS - 12 SN - 0277-9536, 0277-9536 KW - Physician migration KW - Health policy KW - Developing countries KW - India KW - Pakistan KW - Nigeria KW - Columbia KW - The Philippines KW - Doctors KW - Migration KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57185034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=Physician+Migration%3A+Views+from+Professionals+in+Colombia%2C+Nigeria%2C+India%2C+Pakistan+and+the+Philippines&rft.au=Astor%2C+Avraham%3BAkhtar%2C+Tasleem%3BMatallana%2C+Maria+Alexandra%3BMuthuswamy%2C+Vasantha%3BOlowu%2C+Folarin+A%3BTallo%2C+Veronica%3BLie%2C+Reidar+K&rft.aulast=Astor&rft.aufirst=Avraham&rft.date=2005-12-01&rft.volume=61&rft.issue=12&rft.spage=2492&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2005.05.003 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-07-28 N1 - Last updated - 2016-09-27 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Doctors; Migration; Health policy; Developing countries DO - http://dx.doi.org/10.1016/j.socscimed.2005.05.003 ER - TY - JOUR T1 - Dysbindin (DTNBP1, 6p22.3) Is Associated with Childhood-Onset Psychosis and Endophenotypes Measured by the Premorbid Adjustment Scale (PAS) AN - 57044953; 200614510 AB - Straub et al. (2002) recently identified the 6p22.3 gene dysbindin (DTNBP1) through positional cloning as a schizophrenia susceptibility gene. We studied a rare cohort of 102 children with onset of psychosis before age 13. Standardized ratings of early development, medication response, neuropsychological & cognitive performance, premorbid dysfunction & clinical follow-up were obtained. Fourteen SNPs were genotyped in the gene DTNBP1. Family-based pairwise & haplotype transmission disequilibrium test (TDT) analysis with the clinical phenotype, & quantitative transmission disequilibrium test (QTDT) explored endophenotype relationships. One SNP was associated with diagnosis (TDT p=.01). The QTDT analyses showed several significant relationships. Four adjacent SNPs were associated (p values=.0009-.003) with poor premorbid functioning. These findings support the hypothesis that this & other schizophrenia susceptibility genes contribute to early neurodevelopmental impairment. 3 Tables, 38 References. Adapted from the source document. JF - Journal of Autism and Developmental Disorders AU - Gornick, M C AU - Addington, A M AU - Sporn, A AU - Gogtay, N AU - Greenstein, D AU - Lenane, M AU - Gochman, P AU - Ordonez, A AU - Balkissoon, R AU - Vakkalanka, R AU - Weinberger, D R AU - Rapoport, J L AU - Straub, R E AD - c/o Rapoport -- Child Psychiatry Branch, IRP, National Instit Mental Health, Bethesda, MD Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 831 EP - 838 PB - Springer, Dordrecht The Netherlands VL - 35 IS - 6 SN - 0162-3257, 0162-3257 KW - Candidate gene KW - genetic association KW - transmission disequilibrium test KW - quantitative TDT KW - schizophrenia KW - DTNBP1 KW - childhood onset KW - Schizophrenia KW - Genetics KW - Phenotypes KW - Psychoses KW - Childhood onset KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57044953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Dysbindin+%28DTNBP1%2C+6p22.3%29+Is+Associated+with+Childhood-Onset+Psychosis+and+Endophenotypes+Measured+by+the+Premorbid+Adjustment+Scale+%28PAS%29&rft.au=Gornick%2C+M+C%3BAddington%2C+A+M%3BSporn%2C+A%3BGogtay%2C+N%3BGreenstein%2C+D%3BLenane%2C+M%3BGochman%2C+P%3BOrdonez%2C+A%3BBalkissoon%2C+R%3BVakkalanka%2C+R%3BWeinberger%2C+D+R%3BRapoport%2C+J+L%3BStraub%2C+R+E&rft.aulast=Gornick&rft.aufirst=M&rft.date=2005-12-01&rft.volume=35&rft.issue=6&rft.spage=831&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/10.1007%2Fs10803-005-0028-3 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-10-02 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDDQ N1 - SubjectsTermNotLitGenreText - Genetics; Psychoses; Phenotypes; Schizophrenia; Childhood onset DO - http://dx.doi.org/10.1007/s10803-005-0028-3 ER - TY - CPAPER T1 - Genetic Marking Studies in Non-Human Primates: Insights into Hematopoiesis and Leukemogenesis T2 - 2005 Euroconference on Gene and Cell Therapy AN - 40099002; 4041880 JF - 2005 Euroconference on Gene and Cell Therapy AU - Dunbar, Cynthia E Y1 - 2005/12/01/ PY - 2005 DA - 2005 Dec 01 KW - Leukemogenesis KW - Hemopoiesis KW - Primates KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40099002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Euroconference+on+Gene+and+Cell+Therapy&rft.atitle=Genetic+Marking+Studies+in+Non-Human+Primates%3A+Insights+into+Hematopoiesis+and+Leukemogenesis&rft.au=Dunbar%2C+Cynthia+E&rft.aulast=Dunbar&rft.aufirst=Cynthia&rft.date=2005-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Euroconference+on+Gene+and+Cell+Therapy&rft.issn=&rft_id=info:doi/ L2 - http://www.pasteur.fr/applications/euroconf/geneandcelltherapy/gene-program me.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Addiction and its brain science AN - 37698390; 3253554 AB - Aims To illustrate how modern neurobiological approaches will help to identify the neurocircuits and genes involved in addictive behavior. Background The current disorder concept of addiction includes neurobiological foundations and neurobiological research assuming irreversible molecular and structural changes within the brain dopamine reinforcement system, constituting the 'molecular and structural switch' from controlled drug intake to compulsive drug abuse. However, those irreversible changes have not so far been identified and it is suggested that in addition to the mesolimbic dopamine system, other brain systems including the mesocortical and nigrostriatal pathways as well as their non-dopaminergic feedback-loops might be involved in addictive behavior. Neurobiological approach A three-step neurobiological approach is described that allows in a first step via novel animal models and imaging techniques to identify the neuroanatomical sites mediating voluntary drug intake, reinstatement of drug-seeking behavior, relapse, loss of control and drug intake despite negative consequences. In a subsequent step, forward genetic approaches including quantitative trait loci (QTL)-analysis and gene expression profiling are helpful in identifying so-called candidate genes. In a final step, conditional animal mutants and selective pharmacological tools are used to functionally validate candidate genes. Following this validation process, the transfer to the human situation has to be made and candidate genes have to be verified further in well-phenotyped cohorts of addicted patients. Conclusion This three-step neurobiological approach, that must involve an interdisciplinary team including experimental psychologists, geneticists, molecular biologists and finally clinical addiction researchers, will allow us to understand where and how the addicted brain goes awry. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Spanagel, Rainer AU - Heilig, Markus AD - University of Heidelberg ; National Institute on Alcohol Abuse and Alcoholism Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1813 EP - 1822 VL - 100 IS - 12 SN - 0965-2140, 0965-2140 KW - Sociology KW - Genetics KW - Behavioural psychology KW - Brain KW - Social problems KW - Health KW - Addiction KW - Drugs KW - Neurology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37698390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Addiction+and+its+brain+science&rft.au=Spanagel%2C+Rainer%3BHeilig%2C+Markus&rft.aulast=Spanagel&rft.aufirst=Rainer&rft.date=2005-12-01&rft.volume=100&rft.issue=12&rft.spage=1813&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2005.01260.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5772; 11893 11979; 561 6220; 1750 1678; 8635; 1540 1543 10404; 3755; 5460 1615 8573 11325 DO - http://dx.doi.org/10.1111/j.1360-0443.2005.01260.x ER - TY - JOUR T1 - Developmental differences in the function and use of anatomical dolls during interviews with alleged sexual abuse victims AN - 36524710; 3315465 AB - The impact of anatomical dolls on reports provided by 3- to 12-year-old alleged sexual abuse victims (N = 178) was examined. Children produced as many details in response to open-ended invitations with and without the dolls. In response to directive questions, the 3- to 6-year-olds were more likely to reenact behaviorally than to report verbally, whereas the 7- to 12-year-olds produced more verbal details than enactments when using the dolls. With the dolls, the younger children were more likely than the older children to play suggestively and to contradict details provided without the dolls, whereas the older children were more likely to provide details that were consistent. Children in both age groups produced proportionally more fantastic details with the dolls than without the dolls. Reprinted by permission of the American Psychological Association JF - Journal of consulting and clinical psychology AU - Thierry, Karen L AU - Lamb, Michael E AU - Orbach, Yael AU - Pipe, Margaret-Ellen AD - State University of New Jersey ; University of Cambridge ; National Institute of Child Health and Human Development Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1125 EP - 1134 VL - 73 IS - 6 SN - 0022-006X, 0022-006X KW - Sociology KW - Body KW - Memory KW - Social psychology KW - Sexual abuse KW - Childhood KW - Behavioural psychology KW - Interviews KW - Psychopathology KW - Anatomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36524710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+consulting+and+clinical+psychology&rft.atitle=Developmental+differences+in+the+function+and+use+of+anatomical+dolls+during+interviews+with+alleged+sexual+abuse+victims&rft.au=Thierry%2C+Karen+L%3BLamb%2C+Michael+E%3BOrbach%2C+Yael%3BPipe%2C+Margaret-Ellen&rft.aulast=Thierry&rft.aufirst=Karen&rft.date=2005-12-01&rft.volume=73&rft.issue=6&rft.spage=1125&rft.isbn=&rft.btitle=&rft.title=Journal+of+consulting+and+clinical+psychology&rft.issn=0022006X&rft_id=info:doi/10.1037%2F0022-006X.73.6.1125 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 10409; 2211 652 5676 646 6091 2212; 1540 1543 10404; 11901 10404; 11559 11540 3015 11881; 7930; 6832 10919; 981 1615 8573 11325; 1678 DO - http://dx.doi.org/10.1037/0022-006X.73.6.1125 ER - TY - JOUR T1 - Evidence for a gene-environment interaction in predicting behavioral inhibition in middle childhood AN - 36488019; 3298343 AB - Gene-environment interactions are presumed to shape human behavior during early development. However, no human research has demonstrated that such interactions lead to stable individual differences in fear responses. We tested this possibility by focusing on a polymorphism in the promoter region of the gene for the serotonin transporter (5-HTT). This polymorphism has been linked to many indices of serotonin activity. Specifically, we tested the hypothesis that an interaction between children's 5-HTT status and maternal reports of social support predicts inhibited behavior with unfamiliar peers in middle childhood. Results were consistent with this hypothesis: Children with the combination of the short 5-HTT allele and low social support had increased risk for behavioral inhibition in middle childhood. Reprinted by permission of Sage Publications JF - Psychological science AU - Fox, Nathan A AU - Nichols, Kate E AU - Henderson, Heather A AU - Rubin, Kenneth AU - Schmidt, Louis AU - Hamer, Dean AU - Ernst, Monique AU - Pine, Daniel S AD - University of Maryland ; University of Miami ; McMaster University ; National Cancer Institute Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 921 EP - 926 VL - 16 IS - 12 SN - 0956-7976, 0956-7976 KW - Sociology KW - Genetics KW - Childhood KW - Behavioural psychology KW - Social environment KW - Psychopathology KW - Developmental psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36488019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+science&rft.atitle=Evidence+for+a+gene-environment+interaction+in+predicting+behavioral+inhibition+in+middle+childhood&rft.au=Fox%2C+Nathan+A%3BNichols%2C+Kate+E%3BHenderson%2C+Heather+A%3BRubin%2C+Kenneth%3BSchmidt%2C+Louis%3BHamer%2C+Dean%3BErnst%2C+Monique%3BPine%2C+Daniel+S&rft.aulast=Fox&rft.aufirst=Nathan&rft.date=2005-12-01&rft.volume=16&rft.issue=12&rft.spage=921&rft.isbn=&rft.btitle=&rft.title=Psychological+science&rft.issn=09567976&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 10409; 11829 6077 4309; 2211 652 5676 646 6091 2212; 1540 1543 10404; 3518 10404; 5460 1615 8573 11325 ER - TY - JOUR T1 - Opinion: A candidate gene approach to searching for low-penetrance breast and prostate cancer genes AN - 275118034; 16341085 AB - Most cases of breast and prostate cancer are not associated with mutations in known high-penetrance genes, indicating the involvement of multiple low-penetrance risk alleles. Studies that have attempted to identify these genes have met with limited success. The National Cancer Institute Breast and Prostate Cancer Cohort Consortium--a pooled analysis of multiple large cohort studies with a total of more than 5,000 cases of breast cancer and 8,000 cases of prostate cancer--was therefore initiated. The goal of this consortium is to characterize variations in approximately 50 genes that mediate two pathways that are associated with these cancers--the steroid-hormone metabolism pathway and the insulin-like growth factor signalling pathway--and to associate these variations with cancer risk. JF - Nature Reviews. Cancer AU - Hunter, David Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 977 EP - 85 CY - London PB - Nature Publishing Group VL - 5 IS - 12 SN - 1474175X KW - Medical Sciences--Oncology KW - Gonadal Steroid Hormones KW - Prostatic Neoplasms -- metabolism KW - Humans KW - Cohort Studies KW - Gonadal Steroid Hormones -- metabolism KW - Breast Neoplasms -- metabolism KW - Male KW - Female KW - Breast Neoplasms -- genetics KW - Penetrance KW - Genes, Neoplasm KW - Prostatic Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/275118034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews.+Cancer&rft.atitle=Opinion%3A+A+candidate+gene+approach+to+searching+for+low-penetrance+breast+and+prostate+cancer+genes&rft.au=Hunter%2C+David&rft.aulast=Hunter&rft.aufirst=David&rft.date=2005-12-01&rft.volume=5&rft.issue=12&rft.spage=977&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews.+Cancer&rft.issn=1474175X&rft_id=info:doi/10.1038%2Fnrc1754 LA - English DB - ProQuest Central N1 - Copyright - Copyright Nature Publishing Group Dec 2005 N1 - Last updated - 2014-04-30 DO - http://dx.doi.org/10.1038/nrc1754 ER - TY - JOUR T1 - In vivo single-shot, proton-localized 13C MRS of rhesus monkey brain AN - 21067891; 8632097 AB - A single-shot, proton-localized, polarization transfer 13C spectroscopic method was proposed and implemented on a 4.7T scanner for studying rhesus monkey brains. The polarization transfer sequence was mostly adiabatic, minimizing signal loss due to B1 inhomogeneity. RF pulses in polarization transfer were also used for voxel selection of protons with gradient fields. The transferred 13C magnetization was refocused by additional refocusing adiabatic pulses. With the intravenous infusion of D-[1-13C]glucose solution, 13C NMR spectra from a 30mL voxel were acquired for the resonances of C1 of glucose, C2,3,4 of glutamate and glutamine. The time-resolved turnover of glutamate, glutamine and aspartate from intravenously infused D-[1-13C]glucose at a temporal resolution of 12min was demonstrated with excellent spectral resolution and signal-to-noise ratio. Typically, the half-height linewidth of the decoupled 13C peaks was 4Hz. Data obtained with infusion of sodium [2-13C]acetate using the proposed polarization transfer method and data from the carboxylic carbon region using non-localized acquisition are also presented. Published in 2005 by John Wiley & Sons, Ltd. JF - NMR in Biomedicine AU - Li, Shizhe AU - Chen, Zhengguang AU - Zhang, Yan AU - Lizak, Martin AU - Bacher, John AU - Innis, Robert B AU - Shen, Jun AD - National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA, shenj@intra.nimh.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 560 EP - 569 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 18 IS - 8 SN - 0952-3480, 0952-3480 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Glutamine KW - Glucose KW - Carbon KW - N.M.R. KW - Macaca mulatta KW - Intravenous administration KW - Data processing KW - Protons KW - Brain KW - Polarization KW - Sodium KW - Adiabatic KW - Glutamic acid KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21067891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=In+vivo+single-shot%2C+proton-localized+13C+MRS+of+rhesus+monkey+brain&rft.au=Li%2C+Shizhe%3BChen%2C+Zhengguang%3BZhang%2C+Yan%3BLizak%2C+Martin%3BBacher%2C+John%3BInnis%2C+Robert+B%3BShen%2C+Jun&rft.aulast=Li&rft.aufirst=Shizhe&rft.date=2005-12-01&rft.volume=18&rft.issue=8&rft.spage=560&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=09523480&rft_id=info:doi/10.1002%2Fnbm.993 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Macaca mulatta; Polarization; Glutamic acid; Data processing; Brain; N.M.R.; Adiabatic; Glutamine; Carbon; Sodium; Intravenous administration; Glucose; Protons DO - http://dx.doi.org/10.1002/nbm.993 ER - TY - JOUR T1 - A diffusion tensor imaging analysis of gender differences in water diffusivity within human skeletal muscle AN - 21063363; 8632089 AB - The diffusive properties of adjacent muscles at rest were evaluated in male (n=12) and female (n=12) subjects using diffusion tensor imaging (DTI). The principle, second and third eigenvalues, trace of the diffusion tensor [Tr(D)], and two anisotropic parameters, ellipsoid eccentricity (e) and fractional anisotropy (FA), of various muscles in the human calf were calculated from the diffusion tensor. Seven muscles were investigated in this study from images acquired of the left calf: the soleus, lateral gastrocnemius, medial gastrocnemius, posterior tibialis, anterior tibialis, extensor digitorum longus and peroneus longus. A mathematical model was also derived that relates the eigenvalues of the diffusion tensor to the muscle fiber volume fraction, which is defined as the volume of muscle fibers within a well-defined arbitrary muscle volume. Females on average had higher eigenvalues and Tr(D) compared with males, with the majority of muscles being statistically different between the sexes. In contrast, males on average had higher e and FA than females, with the large plantar flexors-soleus, lateral gastrocnemius, and medial gastrocnemius-producing statistically different results. The behavior of the mathematical model for variations in fiber volume fraction produced similar trends to those seen when the experimental data were fit to the model. The model predicts that a larger volume fraction of skeletal muscle in males is devoted to fibers than in females, but the true underlying source of the gender discrepancy remains unclear. Although the model does not fully account for other transport processes, it does provide some insight into the limiting factors that affect the diffusion of water in skeletal muscle measured by DTI. JF - NMR in Biomedicine AU - Galban, Craig J AU - Maderwald, Stefan AU - Uffmann, Kai AU - Ladd, Mark E AD - Department of Diagnostic and Interventional Radiology, University Hospital Essen, Hufelandstrasse 55, D-45122 Essen, Germany, galbanc@ors.od.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 489 EP - 498 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 18 IS - 8 SN - 0952-3480, 0952-3480 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Anisotropy KW - Mathematical models KW - Magnetic resonance imaging KW - Diffusion KW - N.M.R. KW - Skeletal muscle KW - Limiting factors KW - Sex differences KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21063363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=A+diffusion+tensor+imaging+analysis+of+gender+differences+in+water+diffusivity+within+human+skeletal+muscle&rft.au=Galban%2C+Craig+J%3BMaderwald%2C+Stefan%3BUffmann%2C+Kai%3BLadd%2C+Mark+E&rft.aulast=Galban&rft.aufirst=Craig&rft.date=2005-12-01&rft.volume=18&rft.issue=8&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=09523480&rft_id=info:doi/10.1002%2Fnbm.975 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Skeletal muscle; Mathematical models; Anisotropy; Magnetic resonance imaging; Sex differences; Data processing; N.M.R.; Diffusion; Limiting factors DO - http://dx.doi.org/10.1002/nbm.975 ER - TY - JOUR T1 - CpG-containing oligodeoxynucleotide promotes microglial cell uptake of amyloid ss 1-42 peptide by up-regulating the expression of the G-protein-coupled receptor mFPR2 AN - 21053094; 7327148 AB - Inflammation contributes to the pathogenic process of Alzheimer's disease (AD). We previously discovered that a human G-protein-coupled formyl peptide receptor-like 1 (FPRL1) and its mouse homologue mFPR2 mediate the chemotaxis and activation of mononuclear phagocytes in response to a variety of peptide agonists, including amyloid ss 1-42 (Ass sub(42)), which is neurotoxic and a key mediator of inflammatory responses in AD. Since mFPR2 is up-regulated in mouse microglia by lipopolysaccharide (LPS), a Toll-like receptor 4 ligand, the aim of this study is to investigate whether TLR9, which is activated by CpG-containing oligodeoxynucleotide (ODN) as well as by potential agonists released by damaged host cells, may also enhance the expression and function of mFPR2, thereby affecting the progress of AD. JF - FASEB Journal AU - Iribarren, P AU - Chen, K AU - Hu, J AU - Gong, W AU - Cho, E H AU - Lockett, S AU - Uranchimeg, B AU - Wang, J M AD - Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Bldg. 560, Room 31-40, Frederick, MD 21702-1201, USA, wangji@mail.ncifcrf.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 2032 EP - 2034 VL - 19 IS - 14 SN - 0892-6638, 0892-6638 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Alzheimer's disease KW - Chemotaxis KW - Oligonucleotides KW - ^b-Amyloid KW - G protein-coupled receptors KW - Phagocytes KW - Lipopolysaccharides KW - Microglial cells KW - TLR4 protein KW - TLR9 protein KW - Microglia KW - Inflammation KW - Neurodegenerative diseases KW - Neurotoxicity KW - formyl peptide receptor-like 1 KW - ^AG protein-coupled receptors KW - Toll-like receptors KW - b-Amyloid KW - N3 11028:Neuropharmacology & toxicology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21053094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+Journal&rft.atitle=CpG-containing+oligodeoxynucleotide+promotes+microglial+cell+uptake+of+amyloid+ss+1-42+peptide+by+up-regulating+the+expression+of+the+G-protein-coupled+receptor+mFPR2&rft.au=Iribarren%2C+P%3BChen%2C+K%3BHu%2C+J%3BGong%2C+W%3BCho%2C+E+H%3BLockett%2C+S%3BUranchimeg%2C+B%3BWang%2C+J+M&rft.aulast=Iribarren&rft.aufirst=P&rft.date=2005-12-01&rft.volume=19&rft.issue=14&rft.spage=2032&rft.isbn=&rft.btitle=&rft.title=FASEB+Journal&rft.issn=08926638&rft_id=info:doi/10.1096%2Ffj.05-4578fje LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Alzheimer's disease; Neurodegenerative diseases; Oligonucleotides; Lipopolysaccharides; Inflammation; Toll-like receptors; b-Amyloid; Phagocytes; Microglia; formyl peptide receptor-like 1; TLR9 protein; TLR4 protein; Microglial cells; Chemotaxis; G protein-coupled receptors; Neurotoxicity; ^b-Amyloid; ^AG protein-coupled receptors DO - http://dx.doi.org/10.1096/fj.05-4578fje ER - TY - JOUR T1 - Conjugates of Group A and W135 Capsular Polysaccharides of Neisseria meningitidis Bound to Recombinant Staphylococcus aureus Enterotoxin C1: Preparation, Physicochemical Characterization, and Immunological Properties in Mice AN - 20986440; 7142798 AB - Neisseria meningitidis groups A (GAM) and W135 capsular polysaccharides (CPs) were bound to recombinant Staphylococcus aureus enterotoxin C1 (rSEC). The CPs were activated with 1-cyano-4-dimethylaminopyridinium tetrafluoroborate and then bound to adipic acid dihydrazide derivatives of rSEC. Syntheses were conducted with native GAM CP (GAMP), W135 CP (W135P), and ultrasonicated or hydrazine-treated W135P at various concentrations of reactants, pHs, and ionic strengths. The conjugates were characterized by compositional and serologic analyses, high-performance size-exclusion chromatography with multi-angle laser light scattering detection, and immunogenicity in 5- to 6-week-old mice. Conjugates injected subcutaneously in phosphate-buffered saline elicited immunoglobulin G (IgG) responses against their respective CPs and rSEC, whereas GAMP and W135P alone did not induce detectable CP antibodies. The O-acetyl content of W135P was low, and its removal had no adverse effect upon the conjugate's immunogenicity. Reduction of the molecular size of W135P by treatment with hydrazine improved the immunogenicity of W135P-rSEC. IgG anti-CP elicited by the conjugates showed complement-dependent bactericidal activity against their respective organisms, and IgG anti-rSEC neutralized the T-cell proliferative activity of native SEC. A bivalent formulation of GAMP-rSEC and W135P-rSEC elicited IgG anti-CP at comparable levels to those induced by the conjugates administered separately. JF - Infection and Immunity AU - Jin, Zhigang AU - Bohach, Gregory A AU - Shiloach, Joseph AU - Norris, Scott E AU - Freedberg, Daron I AU - Deobald, Claudia AU - Coxon, Bruce AU - Robbins, John B AU - Schneerson, Rachel AD - National Institute of Child Health and Human Development. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892. Department of Microbiology, Molecular Biology and Biochemistry, University of Idaho, Moscow, Idaho 83844. Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892 Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 7887 EP - 7893 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 73 IS - 12 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Ionic strength KW - Hydrazine KW - Chromatography KW - Light scattering KW - Neisseria meningitidis KW - Adipic acid dihydrazide KW - Polysaccharides KW - Immunogenicity KW - Lymphocytes T KW - Immunoglobulin G KW - Lasers KW - Enterotoxins KW - Staphylococcus aureus KW - Bactericidal activity KW - Capsular polysaccharides KW - Side effects KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20986440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Conjugates+of+Group+A+and+W135+Capsular+Polysaccharides+of+Neisseria+meningitidis+Bound+to+Recombinant+Staphylococcus+aureus+Enterotoxin+C1%3A+Preparation%2C+Physicochemical+Characterization%2C+and+Immunological+Properties+in+Mice&rft.au=Jin%2C+Zhigang%3BBohach%2C+Gregory+A%3BShiloach%2C+Joseph%3BNorris%2C+Scott+E%3BFreedberg%2C+Daron+I%3BDeobald%2C+Claudia%3BCoxon%2C+Bruce%3BRobbins%2C+John+B%3BSchneerson%2C+Rachel&rft.aulast=Jin&rft.aufirst=Zhigang&rft.date=2005-12-01&rft.volume=73&rft.issue=12&rft.spage=7887&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Hydrazine; Ionic strength; Chromatography; Light scattering; Polysaccharides; Adipic acid dihydrazide; Immunogenicity; Immunoglobulin G; Lymphocytes T; Enterotoxins; Lasers; Capsular polysaccharides; Bactericidal activity; Side effects; Neisseria meningitidis; Staphylococcus aureus ER - TY - JOUR T1 - PfCG2, a Plasmodium falciparum protein peripherally associated with the parasitophorous vacuolar membrane, is expressed in the period of maximum hemoglobin uptake and digestion by trophozoites AN - 20957324; 8338134 AB - A Plasmodium falciparum gene closely linked to the chloroquine resistance locus encodes PfCG2, a predicted 320-330 kDa protein. In the parasitized erythrocyte, PfCG2 expression rises sharply in the trophozoite stage and is detected in electron-dense patches along the parasitophorous vacuolar membrane (PVM), in the cytoplasm and in the digestive vacuole (DV). Results of extraction and partitioning experiments show that PfCG2 is a peripheral membrane protein. Exposure of trophozoite-infected erythrocytes to trypsin-containing buffer after streptolysin O permeabilization indicates that PfCG2 is exposed to the erythrocyte cytosol at the outer face of the PVM. PfCG2 is highly susceptible to hydrolysis by aspartic and cysteine proteases and shows dose-dependent accumulation in the presence of protease inhibitors. These results suggest that PfCG2 is delivered from the outside face of the PVM to the DV, where it is broken down by parasite proteases. PfCG2 interacts with erythrocyte cytoplasm and may be associated with processes of hemoglobin uptake and digestion by erythrocytic-stage parasites. JF - Molecular and Biochemical Parasitology AU - Cooper, Roland A AU - Papakrivos, Janni AU - Lane, Kristin D AU - Fujioka, Hisashi AU - Lingelbach, Klaus AU - Wellems, Thomas E AD - Laboratory of Malaria and Vector Research, Twinbrook III, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8132, USA, twellems@niaid.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 167 EP - 176 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl] VL - 144 IS - 2 SN - 0166-6851, 0166-6851 KW - Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Malaria KW - Endocytosis KW - Phagocytosis KW - Protein trafficking KW - Proteases KW - Parasites KW - Proteinase inhibitors KW - Erythrocytes KW - Chloroquine KW - Plasmodium falciparum KW - Membrane proteins KW - Hydrolysis KW - Hemoglobin KW - Digestion KW - Bioaccumulation KW - Cysteine KW - Cytoplasm KW - Vacuoles KW - Cytosol KW - Proteins KW - Haemoglobins KW - Trophozoites KW - Cysteine proteinase KW - G 07880:Human Genetics KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08501:General KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20957324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Biochemical+Parasitology&rft.atitle=PfCG2%2C+a+Plasmodium+falciparum+protein+peripherally+associated+with+the+parasitophorous+vacuolar+membrane%2C+is+expressed+in+the+period+of+maximum+hemoglobin+uptake+and+digestion+by+trophozoites&rft.au=Cooper%2C+Roland+A%3BPapakrivos%2C+Janni%3BLane%2C+Kristin+D%3BFujioka%2C+Hisashi%3BLingelbach%2C+Klaus%3BWellems%2C+Thomas+E&rft.aulast=Cooper&rft.aufirst=Roland&rft.date=2005-12-01&rft.volume=144&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Biochemical+Parasitology&rft.issn=01666851&rft_id=info:doi/10.1016%2Fj.molbiopara.2005.07.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Digestion; Parasites; Bioaccumulation; Cysteine; Cytoplasm; Erythrocytes; Proteins; Hydrolysis; Haemoglobins; Hemoglobin; Vacuoles; Proteinase inhibitors; Cytosol; Chloroquine; Membrane proteins; Cysteine proteinase; Trophozoites; Plasmodium falciparum DO - http://dx.doi.org/10.1016/j.molbiopara.2005.07.009 ER - TY - JOUR T1 - Dependence on diffusion time of apparent diffusion tensor of ex vivo calf tongue and heart AN - 20859707; 8367966 AB - The time dependence of the apparent diffusion tensor of ex vivo calf heart and tongue was measured for diffusion times (d) between 32 and 810 ms. The results showed evidence of restricted diffusion in the muscle tissues of both organs. In regions where the myofibers are parallel, the largest eigenvalue (1) of the diffusion tensor remained the same for all diffusion times measured, while the other eigenvalues (2, 3) decreased by 29-36% between d = 32 ms and d = 400 ms. In regions where the fibers cross, the 1 also changed, decreasing by 17% between d = 32 ms and d = 400 ms. The restricting compartment size and volume fraction were effectively estimated by fitting the time courses of the eigenvalues to a model consisting of a nonrestricted compartment and a cylindrically restricted compartment. To our knowledge, this study is the first demonstrating diffusion time dependence of measured water diffusion tensor in muscular tissue. With improvement in scanning technology, future studies may permit noninvasive, in vivo detection of changes in muscle myoarchitecture due to disease, treatment, and exercise. JF - Magnetic Resonance in Medicine AU - Kim, Sungheon AU - Chi-Fishman, Gloria AU - Barnett, Alan S AU - Pierpaoli, Carlo AD - Physical Disabilities Branch, Department of Rehabilitation Medicine, Clinical Research Center, National Institutes of Health, Bethesda, Maryland, USA, sungheonk@cc.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1387 EP - 1396 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 54 IS - 6 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Scanning KW - Muscles KW - N.M.R. KW - Tongue KW - Diffusion KW - Models KW - Physical training KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20859707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Dependence+on+diffusion+time+of+apparent+diffusion+tensor+of+ex+vivo+calf+tongue+and+heart&rft.au=Kim%2C+Sungheon%3BChi-Fishman%2C+Gloria%3BBarnett%2C+Alan+S%3BPierpaoli%2C+Carlo&rft.aulast=Kim&rft.aufirst=Sungheon&rft.date=2005-12-01&rft.volume=54&rft.issue=6&rft.spage=1387&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20676 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Diffusion; Heart; Muscles; Tongue; N.M.R.; Scanning; Physical training; Models DO - http://dx.doi.org/10.1002/mrm.20676 ER - TY - JOUR T1 - Single heartbeat cardiac tagging for the evaluation of transient phenomena AN - 20859474; 8367974 AB - Many cardiac abnormalities are of a transient nature, creating a beat-to-beat variation in myocardial function. This work presents the cardiac imaging technique for the measurement of regional function during transient cardiac phenomena. All information necessary for the reconstruction of a cine loop is acquired within a single heartbeat, avoiding the temporal blurring introduced by segmented imaging due to the assumption of cardiac cycle periodicity. This method incorporates a gradient-optimized, high-efficiency EPI-SSFP sequence and TSENSE parallel imaging. For acquisitions with readout resolutions of 128,160, 192, and 256 points, the technique produced images with average temporal resolution of 35, 39, 43, and 52 ms and average spatial resolutions of 2.65, 2.12, 1.77, and 1.32 mm in the readout direction, respectively, and 2.88 and 2.08 mm in the phase encode direction for acceleration rates of 3 and 4, respectively. Local apparent strains in the single slice and measurements of ventricular end-systolic and end-diastolic areas were used as quantitative measures to validate the single heartbeat technique. To demonstrate the utility of the sequence, movie loops were acquired for multiple heartbeats in non-breath-held acquisitions as well as during a Valsalva maneuver. A heartbeat-interleaved acquisition allowed for the reconstruction of nonaccelerated images from R contiguous heartbeats. Images reconstructed from such data displayed tag blurring and reduced tag persistence due to motion and interheartbeat variability. Images acquired during the Valsalva maneuver demonstrated apparent beat-to-beat variability, visible both in the images and as changing strain patterns and ventricular volumes. JF - Magnetic Resonance in Medicine AU - Herzka, Daniel A AU - Derbyshire, J Andrew AU - Kellman, Peter AU - McVeigh, Elliot R AD - Department of Biomedical Engineering, Johns Hopkins University School of Medicine Baltimore, Maryland, USA, herzkad@nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1455 EP - 1464 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 54 IS - 6 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Data processing KW - Image processing KW - Periodicity KW - spatial discrimination KW - N.M.R. KW - imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20859474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Single+heartbeat+cardiac+tagging+for+the+evaluation+of+transient+phenomena&rft.au=Herzka%2C+Daniel+A%3BDerbyshire%2C+J+Andrew%3BKellman%2C+Peter%3BMcVeigh%2C+Elliot+R&rft.aulast=Herzka&rft.aufirst=Daniel&rft.date=2005-12-01&rft.volume=54&rft.issue=6&rft.spage=1455&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20719 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Heart; imaging; N.M.R.; Data processing; Image processing; spatial discrimination; Periodicity DO - http://dx.doi.org/10.1002/mrm.20719 ER - TY - JOUR T1 - Image reconstruction in SNR units: A general method for SNR measurement AN - 20859112; 8367972 AB - The method for phased array image reconstruction of uniform noise images may be used in conjunction with proper image scaling as a means of reconstructing images directly in SNR units. This facilitates accurate and precise SNR measurement on a per pixel basis. This method is applicable to root-sum-of-squares magnitude combining, B1-weighted combining, and parallel imaging such as SENSE. A procedure for image reconstruction and scaling is presented, and the method for SNR measurement is validated with phantom data. Alternative methods that rely on noise only regions are not appropriate for parallel imaging where the noise level is highly variable across the field-of-view. The purpose of this article is to provide a nuts and bolts procedure for calculating scale factors used for reconstructing images directly in SNR units. The procedure includes scaling for noise equivalent bandwidth of digital receivers, FFTs and associated window functions (raw data filters), and array combining. JF - Magnetic Resonance in Medicine AU - Kellman, Peter AU - McVeigh, Elliot R AD - Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland 20892-1061, USA, kellman@nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1439 EP - 1447 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 54 IS - 6 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Filters KW - Data processing KW - Nuts KW - Image processing KW - N.M.R. KW - imaging KW - Scaling KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20859112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Image+reconstruction+in+SNR+units%3A+A+general+method+for+SNR+measurement&rft.au=Kellman%2C+Peter%3BMcVeigh%2C+Elliot+R&rft.aulast=Kellman&rft.aufirst=Peter&rft.date=2005-12-01&rft.volume=54&rft.issue=6&rft.spage=1439&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20713 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Scaling; Image processing; Data processing; imaging; N.M.R.; Filters; Nuts DO - http://dx.doi.org/10.1002/mrm.20713 ER - TY - JOUR T1 - Absolute oxygen tension (pO2) in murine fatty and muscle tissue as determined by EPR AN - 20856783; 8367981 AB - The absolute partial pressure of oxygen (pO2) in the mammary gland pad and femoral muscle of female mice was measured using EPR oximetry at 700 MHz. A small quantity of lithium phthalocyanine (LiPc) crystals was implanted in both mammary and femoral muscle tissue of female C3H mice. Subsequent EPR measurements were carried out 1-30 days after implantation with or without control of core body temperature. The pO2 values in the tissue became stable 2 weeks after implantation of LiPc crystals. The pO2 level was found to be higher in the femoral muscle than in the mammary tissue. However, the pO2 values showed a strong dependence on the core body temperature of the mice. The pO2 values were responsive to carbogen (95% O2, 5% CO2) breathing even 44-58 days after the implantation of LiPc. The LiPc linewidth was also sensitive to changes in the blood supply even 60 days after implantation of the crystals. This study further validates the use of LiPc crystals and EPR oximetry for long-term non-invasive assessment of pO2 levels in tissues, underscores the importance of maintaining normal body core temperature during the measurements, and demonstrates that mammary tissue functions at a lower pO2 level than muscle in female C3H mice. JF - Magnetic Resonance in Medicine AU - Matsumoto, Atsuko AU - Matsumoto, Shingo AU - Sowers, Anastasia L AU - Koscielniak, Janusz W AU - Trigg, Nancy J AU - Kuppusamy, Periannan AU - Mitchell, James B AU - Subramanian, Sankaran AU - Krishna, Murali C AU - Matsumoto, Ken-ichiro AD - Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA, murali@helix.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1530 EP - 1535 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 54 IS - 6 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Oxygen tension KW - Body temperature KW - Mammary gland KW - Respiration KW - Muscles KW - Crystals KW - Femur KW - Blood KW - N.M.R. KW - Pressure KW - Carbon dioxide KW - Lithium KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20856783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Absolute+oxygen+tension+%28pO2%29+in+murine+fatty+and+muscle+tissue+as+determined+by+EPR&rft.au=Matsumoto%2C+Atsuko%3BMatsumoto%2C+Shingo%3BSowers%2C+Anastasia+L%3BKoscielniak%2C+Janusz+W%3BTrigg%2C+Nancy+J%3BKuppusamy%2C+Periannan%3BMitchell%2C+James+B%3BSubramanian%2C+Sankaran%3BKrishna%2C+Murali+C%3BMatsumoto%2C+Ken-ichiro&rft.aulast=Matsumoto&rft.aufirst=Atsuko&rft.date=2005-12-01&rft.volume=54&rft.issue=6&rft.spage=1530&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20714 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Muscles; Crystals; Femur; Body temperature; Carbon dioxide; Blood; Oxygen tension; N.M.R.; Respiration; Mammary gland; Lithium; Pressure DO - http://dx.doi.org/10.1002/mrm.20714 ER - TY - JOUR T1 - Real-time blood flow imaging using autocalibrated spiral sensitivity encoding AN - 20854987; 8367986 AB - A novel spiral phase contrast (PC) technique was developed for high temporal resolution imaging of blood flow without cardiac gating. An autocalibrated spiral sensitivity encoding (SENSE) method is introduced and used to reconstruct PC images. Numerical simulations and a flow phantom study were performed to validate the technique. To study the accuracy of the flow measurement in vivo, a high-resolution cardiac experiment was performed and a subset of undersampled SENSE reconstructed data were reconstructed. Good agreement between the velocity measurement from the fully-sampled and undersampled data was achieved. Real-time experiments were performed to measure blood velocity in the ascending aorta and aortic valve, and during a Valsalva maneuver. The results demonstrate the potential of this technique for real-time flow imaging. JF - Magnetic Resonance in Medicine AU - Nezafat, Reza AU - Kellman, Peter AU - Derbyshire, J Andrew AU - McVeigh, Elliot R AD - Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA, nezafatr@nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1557 EP - 1561 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 54 IS - 6 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Data processing KW - Aortic valve KW - Aorta KW - Gating KW - N.M.R. KW - imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20854987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Real-time+blood+flow+imaging+using+autocalibrated+spiral+sensitivity+encoding&rft.au=Nezafat%2C+Reza%3BKellman%2C+Peter%3BDerbyshire%2C+J+Andrew%3BMcVeigh%2C+Elliot+R&rft.aulast=Nezafat&rft.aufirst=Reza&rft.date=2005-12-01&rft.volume=54&rft.issue=6&rft.spage=1557&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20690 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - imaging; Data processing; Heart; N.M.R.; Gating; Aortic valve; Aorta DO - http://dx.doi.org/10.1002/mrm.20690 ER - TY - JOUR T1 - In vivo carbon-13 magnetization transfer effect. Detection of aspartate aminotransferase reaction AN - 20852952; 8367958 AB - One of the most remarkable achievements of in vivo NMR spectroscopy has been the detection of rapid enzyme-catalyzed exchange reactions using phosphorus-31 magnetic resonance spectroscopy-based magnetization transfer experiments. In this paper, we report, for the first time, the in vivo carbon magnetization transfer (CMT) effect and in vivo detection of the CMT effects of the -ketoglutarate glutamate and the oxaloacetate aspartate reactions, both of which are catalyzed by aspartate aminotransferase. By saturating the carbonyl carbon of -ketoglutarate at 206 ppm in -chloralose anesthetized adult rat brain, the unidirectional glutamate -ketoglutarate flux was determined to be 78 - 9 mol/g/min (mean - SD, n = 11) following i.v. infusion of [1,6-13C2]D-glucose. Contribution from aspartate aminotransferase-catalyzed partial reactions to the observed CMT effects was emphasized. Because of the large chemical shift separation between the -carbons of the amino acids and the carbonyl carbons of the corresponding cognate keto acids, the spillover of the saturation radiofrequency pulses to the -carbon resonances was negligible. The results indicate that the magnetization transfer effects of aspartate aminotransferase-catalyzed reactions can be used as new biomarkers accessible to non-invasive in vivo magnetic resonance spectroscopy techniques. JF - Magnetic Resonance in Medicine AU - Shen, Jun AD - Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland, USA, shenj@intra.nimh.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1321 EP - 1326 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 54 IS - 6 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Amino acids KW - Carbon KW - Aspartate aminotransferase KW - Acids KW - Magnetic resonance spectroscopy KW - Brain KW - N.M.R. KW - Glutamic acid KW - biomarkers KW - carbonyls KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20852952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=In+vivo+carbon-13+magnetization+transfer+effect.+Detection+of+aspartate+aminotransferase+reaction&rft.au=Shen%2C+Jun&rft.aulast=Shen&rft.aufirst=Jun&rft.date=2005-12-01&rft.volume=54&rft.issue=6&rft.spage=1321&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20709 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Carbon; Magnetic resonance spectroscopy; Glutamic acid; N.M.R.; carbonyls; Aspartate aminotransferase; Amino acids; biomarkers; Brain; Acids DO - http://dx.doi.org/10.1002/mrm.20709 ER - TY - JOUR T1 - Immune-Related Conditions and Immune-Modulating Medications as Risk Factors for Non-Hodgkin's Lymphoma: A Case-Control Study AN - 20715076; 6576056 AB - In immunosuppressed or autoimmune disease states, disordered immune responses may lead to non-Hodgkin's lymphoma (NHL). In a US population-based case-control study of NHL (1998-2000), the authors collected personal histories of immune-related conditions and use of immune-modulating therapies as well as family histories of autoimmune conditions. The study included 1,321 NHL cases and 1,057 controls; only half received some questionnaire components. NHL was associated with Sjoegren's syndrome (odds ratio (OR) = 13, 95% confidence interval (CI): 1.7, 100) and lupus (OR = 4.2, 95% CI: 1.2, 15). Two specific NHL subtypes were strongly associated with Sjoegren's syndrome: salivary gland (OR = 290, 95% CI: 33, 2600) and marginal zone (OR = 75, 95% CI: 9.1, 610). NHL was less convincingly associated with receipt of an organ transplant (OR = 2.0, 95% CI: 0.4, 11). Other autoimmune conditions were too rare to evaluate or not associated with NHL. Corticosteroid use was unrelated to NHL (OR = 1.0, 95% CI: 0.8, 1.2), but methotrexate use was marginally associated (OR = 2.3, 95% CI: 0.7, 7.5). Family history of dermatomyositis was associated with NHL (7 cases vs. 0 controls, OR = infinite; two-sided p = 0.02), but dermatomyositis was absent in cases themselves. Family history of remaining conditions was unrelated to NHL. Results suggest that disordered immunity in some immune-related conditions can lead to NHL. JF - American Journal of Epidemiology AU - Engels, Eric A AU - Cerhan, James R AU - Linet, Martha S AU - Cozen, Wendy AU - Colt, Joanne S AU - Davis, Scott AU - Gridley, Gloria AU - Severson, Richard K AU - Hartge, Patricia AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1153 EP - 1161 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 162 IS - 12 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; Immunology Abstracts KW - non-Hodgkin's lymphoma KW - Historical account KW - Inventories KW - Autoimmune diseases KW - autoimmune diseases KW - Immunity KW - Salivary gland KW - Organs KW - Immunomodulation KW - Sjogren's syndrome KW - Genetics KW - Non-Hodgkin's lymphoma KW - Corticoids KW - Dermatomyositis KW - Risk factors KW - Methotrexate KW - Drugs KW - corticoids KW - R2 23060:Medical and environmental health KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20715076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Immune-Related+Conditions+and+Immune-Modulating+Medications+as+Risk+Factors+for+Non-Hodgkin%27s+Lymphoma%3A+A+Case-Control+Study&rft.au=Engels%2C+Eric+A%3BCerhan%2C+James+R%3BLinet%2C+Martha+S%3BCozen%2C+Wendy%3BColt%2C+Joanne+S%3BDavis%2C+Scott%3BGridley%2C+Gloria%3BSeverson%2C+Richard+K%3BHartge%2C+Patricia&rft.aulast=Engels&rft.aufirst=Eric&rft.date=2005-12-01&rft.volume=162&rft.issue=12&rft.spage=1153&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Sjogren's syndrome; Corticoids; Inventories; Non-Hodgkin's lymphoma; Dermatomyositis; Risk factors; Autoimmune diseases; Methotrexate; Immunity; Salivary gland; Immunomodulation; non-Hodgkin's lymphoma; Historical account; Genetics; autoimmune diseases; Drugs; Organs; corticoids ER - TY - JOUR T1 - Countermeasures to the Bioterrorist Threat of Smallpox AN - 20305551; 7653965 AB - Variola, the agent of smallpox, is a bioterrorist threat, as is monkeypox virus, which also occurs naturally in Africa. Development of countermeasures, in the form of improved vaccines, antiviral drugs, and other therapeutic strategies are a high priority. Recent advances in molecular biology and in animal model development have provided fresh insight into the virulence determinants for smallpox and the pathophysiology of disease. The complex replication cycle for orthopoxviruses, and the pivotal role for viralspecific immunomodulatory proteins which contribute to escape from immunologic surveillance, provide many unique targets for therapeutic intervention. The "toxemia" of smallpox has been elucidated in part by variola- infected primate studies which revealed the central role of apoptosis and the evolution of a cytokine storm leading to hemorrhagic diathesis, resembling fulminent "black" smallpox. This suggests a potential role for therapeutic strategies developed for septic shock, in treatment of smallpox. Drugs licensed for other viruses which share molecular targets with orthopoxviruses (e.g. Cidofovir) or cancer drugs (e.g. Gleevec and other tyrosine kinase inhibitors) have immediate application for treatment of smallpox and monkeypox and provide leads for second generation drugs with higher therapeutic indices. Recent advances in identification of virulence determinants and immune evasion genes facilitate the design of alternative vaccines to replace live vaccinia strains that are unsuitable for a large proportion of individuals in a mass immunization campaign. JF - Current Molecular Medicine AU - Jahrling, Peter B AU - Fritz, Elizabeth A AU - Hensley, Lisa E AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6700-B Rockledge Drive, Bethesda, MD 20892-7609, USA. Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 817 EP - 826 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 5 IS - 8 SN - 1566-5240, 1566-5240 KW - Primates KW - Virology & AIDS Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Therapeutic applications KW - Hemorrhage KW - Virulence KW - Protein-tyrosine kinase KW - Variola KW - Monkeypox virus KW - Replication KW - Vaccinia KW - Drug development KW - Septic shock KW - Immunization KW - Vaccines KW - Apoptosis KW - Animal models KW - Immunosuppressive agents KW - Antiviral agents KW - Cytokines KW - Cidofovir KW - Monkeypox KW - Toxemia KW - Cancer KW - Smallpox KW - Evolution KW - F 06905:Vaccines KW - V 22350:Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20305551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Molecular+Medicine&rft.atitle=Countermeasures+to+the+Bioterrorist+Threat+of+Smallpox&rft.au=Jahrling%2C+Peter+B%3BFritz%2C+Elizabeth+A%3BHensley%2C+Lisa+E&rft.aulast=Jahrling&rft.aufirst=Peter&rft.date=2005-12-01&rft.volume=5&rft.issue=8&rft.spage=817&rft.isbn=&rft.btitle=&rft.title=Current+Molecular+Medicine&rft.issn=15665240&rft_id=info:doi/10.2174%2F156652405774962326 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Monkeypox virus; Variola; Primates; Smallpox; Antiviral agents; Immunosuppressive agents; Vaccines; Virulence; Monkeypox; Protein-tyrosine kinase; Vaccinia; Hemorrhage; Cytokines; Apoptosis; Cancer; Replication; Therapeutic applications; Animal models; Evolution; Drug development; Toxemia; Immunization; Septic shock; Cidofovir DO - http://dx.doi.org/10.2174/156652405774962326 ER - TY - JOUR T1 - Perfusion-based fMRI: Insights from animal models AN - 20243437; 7456810 AB - Modern functional neuroimaging techniques, including functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and optical imaging of intrinsic signals (OIS), rely on a tight coupling between neural activity and cerebral blood flow (CBF) to visualize brain activity using CBF as a surrogate marker. Because CBF is a uniquely defined physiological parameter, fMRI techniques based on CBF contrast have the advantage of being specific to tissue signal change, and the potential to provide more direct and quantitative measures of brain activation than blood oxygenation level-dependent (BOLD)- or cerebral blood volume (CBV)-based techniques. The changes in CBF elicited by increased neural activity are an excellent index of the magnitude of electrical activity. Increases in CBF are more closely localized to the foci of increased electrical activity, and occur more promptly to the stimulus than BOLD- or CBV- based contrast. In addition, CBF-based fMRI is less affected by confounds from venous drainage common to BOLD. Animal studies of brain activation have yielded considerable insights into the advantages of CBF-based fMRI. Based on results provided by animal studies, CBF fMRI may offer a means of better assessing the magnitude, spatial extent, and temporal response of neural activity, and may be more specific to tissue state. These properties are expected to be particularly useful for longitudinal and quantitative fMRI studies. J. Magn. Reson. Imaging 2005. Published 2005 Wiley-Liss, Inc. JF - Journal of Magnetic Resonance Imaging AU - Silva, Afonso C AD - Cerebral Microcirculation Unit, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA, silvaa@ninds.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 745 EP - 750 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 22 IS - 6 SN - 1053-1807, 1053-1807 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - functional magnetic resonance imaging KW - arterial spin labeling KW - animal models KW - cerebral blood flow KW - spatial resolution KW - temporal resolution KW - Brain mapping KW - Neuroimaging KW - Functional magnetic resonance imaging KW - Positron emission tomography KW - Animal models KW - Cerebral blood flow KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20243437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Magnetic+Resonance+Imaging&rft.atitle=Perfusion-based+fMRI%3A+Insights+from+animal+models&rft.au=Silva%2C+Afonso+C&rft.aulast=Silva&rft.aufirst=Afonso&rft.date=2005-12-01&rft.volume=22&rft.issue=6&rft.spage=745&rft.isbn=&rft.btitle=&rft.title=Journal+of+Magnetic+Resonance+Imaging&rft.issn=10531807&rft_id=info:doi/10.1002%2Fjmri.20461 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Brain mapping; Neuroimaging; Functional magnetic resonance imaging; Animal models; Positron emission tomography; Cerebral blood flow DO - http://dx.doi.org/10.1002/jmri.20461 ER - TY - JOUR T1 - Technological advances in MRI measurement of brain perfusion AN - 20242018; 7456807 AB - Measurement of brain perfusion using arterial spin labeling (ASL) or dynamic susceptibility contrast (DSC) based MRI has many potential important clinical applications. However, the clinical application of perfusion MRI has been limited by a number of factors, including a relatively poor spatial resolution, limited volume coverage, and low signal-to-noise ratio (SNR). It is difficult to improve any of these aspects because both ASL and DSC methods require rapid image acquisition. In this report, recent methodological developments are discussed that alleviate some of these limitations and make perfusion MRI more suitable for clinical application. In particular, the availability of high magnetic field strength systems, increased gradient performance, the use of RF coil arrays and parallel imaging, and increasing pulse sequence efficiency allow for increased image acquisition speed and improved SNR. The use of parallel imaging facilitates the trade-off of SNR for increases in spatial resolution. As a demonstration, we obtained DSC and ASL perfusion images at 3.0 T and 7.0 T with multichannel RF coils and parallel imaging, which allowed us to obtain high-quality images with in-plane voxel sizes of 1.5 X 1.5 mm super(2). J. Magn. Reson. Imaging 2005. Published 2005 Wiley-Liss, Inc. JF - Journal of Magnetic Resonance Imaging AU - Duyn, Jeff H AU - Van Gelderen, Peter AU - Talagala, Lalith AU - Koretsky, Alan AU - De Zwart, Jacco A AD - Advanced MRI Laboratory, National Institutes of Health, Bethesda, Maryland, USA, jhd@helix.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 751 EP - 753 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 22 IS - 6 SN - 1053-1807, 1053-1807 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - MR imaging KW - perfusion KW - resolution KW - coil arrays KW - parallel imaging KW - Magnetic fields KW - Neuroimaging KW - Perfusion KW - Magnetic resonance imaging KW - Brain KW - spatial discrimination KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20242018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Magnetic+Resonance+Imaging&rft.atitle=Technological+advances+in+MRI+measurement+of+brain+perfusion&rft.au=Duyn%2C+Jeff+H%3BVan+Gelderen%2C+Peter%3BTalagala%2C+Lalith%3BKoretsky%2C+Alan%3BDe+Zwart%2C+Jacco+A&rft.aulast=Duyn&rft.aufirst=Jeff&rft.date=2005-12-01&rft.volume=22&rft.issue=6&rft.spage=751&rft.isbn=&rft.btitle=&rft.title=Journal+of+Magnetic+Resonance+Imaging&rft.issn=10531807&rft_id=info:doi/10.1002%2Fjmri.20450 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Magnetic fields; Neuroimaging; Perfusion; Magnetic resonance imaging; Brain; spatial discrimination DO - http://dx.doi.org/10.1002/jmri.20450 ER - TY - JOUR T1 - Nano-sized MRI contrast agents with dendrimer cores AN - 20219549; 7199800 AB - Gadolinium-based MRI contrast agents (CAs) can be effective at a 100-fold lower concentration of Gadolinium ions in comparison to the concentration of Iodine atoms required for CT imaging. Therefore, a number of dendrimer based macromolecular MRI CAs of various sizes and properties prepared employing relatively simple chemistry are readily available that can provide sufficient contrast enhancement for various applications. Molecules up to 20 nm in diameter behave differently in the body depending on their size. Even if these molecules possess similar chemical properties, small changes in size can greatly impact their pharmacokinetics. Changes in molecular size up to 15 nm in diameter altered permeability across the vascular wall, excretion route, and recognition by the reticuloendothelial system. Smaller sized polyamidoamine (PAMAM) dendrimer-based contrast agents, i.e., less than 3 nm in diameter, easily "leak" across the vascular wall resulting in rapid perfusion throughout the body. Contrast agents 3-6 nm in diameter were quickly excreted through the kidney indicating these agents to be potentially suitable as functional renal contrast agents. Contrast agents 7-12 nm in diameter were retained in circulation and were better suited for use as blood pool contrast agents. Hydrophobic variants of CAs formed with polypropylenimine diaminobutane (DAB) dendrimer cores quickly accumulated in the liver and potentially have use as liver contrast agents. Larger hydrophilic agents have suitable characteristics for lymphatic imaging. Finally, contrast agents conjugated with either monoclonal antibodies or with avidin are able to function as tumor-specific contrast agents and might also be employed as either gadolinium neutron capture therapy or in conjunction with radioimmunotherapy. JF - Advanced Drug Delivery Reviews AU - Kobayashi, Hisataka AU - Brechbiel, Martin W AD - Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Room 1B40, 10 Center Drive, Bethesda, MD 20892-1088, USA, Kobayash@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 2271 EP - 2286 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 57 IS - 15 SN - 0169-409X, 0169-409X KW - Biotechnology Research Abstracts (through 1992) KW - Drug delivery KW - Ions KW - Macromolecules KW - Perfusion KW - Monoclonal antibodies KW - polyamidoamines KW - Gadolinium KW - Magnetic resonance imaging KW - Hydrophobicity KW - Reticuloendothelial system KW - Pharmacokinetics KW - Neutrons KW - Blood KW - Avidin KW - Permeability KW - Reviews KW - Computed tomography KW - Liver KW - Kidney KW - Contrast media KW - Iodine KW - Excretion KW - Vascular system KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20219549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advanced+Drug+Delivery+Reviews&rft.atitle=Nano-sized+MRI+contrast+agents+with+dendrimer+cores&rft.au=Kobayashi%2C+Hisataka%3BBrechbiel%2C+Martin+W&rft.aulast=Kobayashi&rft.aufirst=Hisataka&rft.date=2005-12-01&rft.volume=57&rft.issue=15&rft.spage=2271&rft.isbn=&rft.btitle=&rft.title=Advanced+Drug+Delivery+Reviews&rft.issn=0169409X&rft_id=info:doi/10.1016%2Fj.addr.2005.09.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Contrast media; Magnetic resonance imaging; Kidney; Gadolinium; Liver; Vascular system; Macromolecules; Hydrophobicity; Reticuloendothelial system; Neutrons; Ions; Perfusion; Excretion; Permeability; Reviews; Avidin; Monoclonal antibodies; Iodine; Drug delivery; Pharmacokinetics; polyamidoamines; Computed tomography; Blood DO - http://dx.doi.org/10.1016/j.addr.2005.09.016 ER - TY - JOUR T1 - Replication of Coxiella burnetii Is Inhibited in CHO K-1 Cells Treated with Inhibitors of Cholesterol Metabolism AN - 20198015; 6715703 AB - Coxiella burnetii directs the synthesis of a large parasitophorous vacuole (PV) that is required for its replication. While some lysosomal characteristics of the PV have been described, the origin and composition of the PV membrane remain largely undefined. Cholesterol is an essential component of mammalian membranes where it lends mechanical stability and serves as a platform for signaling proteins. Using infected Chinese hamster ovary cells as a model, we examined whether cholesterol is trafficked to the C. burnetii PV membrane and the effects of inhibitors of cholesterol metabolism on C. burnetii replication. When infected cells were stained with filipin, a fluorescent polyene antifungal agent that binds cholesterol, obvious staining of PV was observed indicating the PV membrane is cholesterol-rich. Furthermore, replication of C. burnetii was significantly inhibited in cells treated with the cholesterol metabolism inhibitors lovastatin, ketoconazole, imipramine, progesterone, and U18666A. These data suggest that cholesterol is an important component of the C. burnetii PV membrane and that normal cellular cholesterol metabolism is required for optimal C. burnetii replication. JF - Annals of the New York Academy of Sciences AU - Howe, Dale AU - Heinzen, Robert A AD - Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 123 EP - 129 PB - New York Academy of Sciences, 2 East 63rd Street New York NY 10021 USA, [mailto:publications@nyas.org], [URL:http://www.nyas.org] VL - 1063 SN - 0077-8923, 0077-8923 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology KW - Antifungal agents KW - Data processing KW - Progesterone KW - Replication KW - Cholesterol KW - Ketoconazole KW - Lipid metabolism KW - parasitophorous vacuole KW - Coxiella burnetii KW - polyenes KW - imipramine KW - Lovastatin KW - Signal transduction KW - J 02320:Cell Biology KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20198015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Replication+of+Coxiella+burnetii+Is+Inhibited+in+CHO+K-1+Cells+Treated+with+Inhibitors+of+Cholesterol+Metabolism&rft.au=Howe%2C+Dale%3BHeinzen%2C+Robert+A&rft.aulast=Howe&rft.aufirst=Dale&rft.date=2005-12-01&rft.volume=1063&rft.issue=&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - parasitophorous vacuole; Antifungal agents; Data processing; Progesterone; imipramine; polyenes; Replication; Cholesterol; Ketoconazole; Lovastatin; Signal transduction; Lipid metabolism; Coxiella burnetii ER - TY - JOUR T1 - Immunochemical detection of flucloxacillin adduct formation in livers of treated rats AN - 20193767; 6906342 AB - Flucloxacillin is a semi-synthetic penicillin widely used in the prophylaxis and treatment of staphylococcal infections. Severe liver reactions, characterised by delayed cholestatic hepatitis and a prolonged course of recovery, are associated with flucloxacillin therapy. Clinical findings are suggestive of an immune mediated reaction but there exists little supporting experimental evidence. The formation of drug modified hepatic protein adducts has been proposed to play an important role in the hepatotoxicity of many drugs. The aim of the present study was to investigate whether flucloxacillin treatment results in adduct formation in vivo. Flucloxacillin was conjugated to rabbit serum albumin by formation of a penicilloyl determinant and used as an immunogen to raise a polyclonal antiserum specific for flucloxacillin-modified proteins. Antibody specificity was confirmed by competitive enzyme-linked immunosorbent assay (ELISA) with free drug. The antiserum was used in combination with western blotting to detect adduct formation in the livers of flucloxacillin treated rats. Western blot analysis of rat liver subcellular fractions revealed the formation of six flucloxacillin adducts in various subcellular fractions. These studies demonstrate for the first time that treatment with flucloxacillin results in the formation of hepatic protein adducts. JF - Toxicology AU - Carey, Michelle A AU - Van Pelt, Frank NAM AD - Department of Pharmacology & Therapeutics, University College Cork, Ireland, carey1@niehs.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 41 EP - 48 PB - Elsevier Science Ireland Ltd., P.O. Box 85 Limerick Ireland VL - 216 IS - 1 SN - 0300-483X, 0300-483X KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Toxicology Abstracts KW - Flucloxacillin KW - Cholestasis KW - Drug-adduct KW - Immunoblotting KW - ELISA KW - Western blotting KW - Enzyme-linked immunosorbent assay KW - Infection KW - Immunosuppressive agents KW - Penicillin KW - hepatotoxicity KW - Hepatitis KW - Antibodies KW - Protein adducts KW - Albumin KW - Prophylaxis KW - Liver KW - Drugs KW - V 22350:Immunology KW - X 24115:Pathology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20193767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Immunochemical+detection+of+flucloxacillin+adduct+formation+in+livers+of+treated+rats&rft.au=Carey%2C+Michelle+A%3BVan+Pelt%2C+Frank+NAM&rft.aulast=Carey&rft.aufirst=Michelle&rft.date=2005-12-01&rft.volume=216&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2005.07.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Western blotting; Enzyme-linked immunosorbent assay; Infection; Immunosuppressive agents; hepatotoxicity; Penicillin; Hepatitis; Antibodies; Protein adducts; Albumin; Liver; Prophylaxis; Flucloxacillin; Drugs DO - http://dx.doi.org/10.1016/j.tox.2005.07.015 ER - TY - JOUR T1 - An amino acid substitution in a capsid protein enhances phage survival in mouse circulatory system more than a 1000-fold AN - 20156733; 6634439 AB - In experiments with germ free mice, free from adaptive antibodies to the bacterial virus lambda phage, titers of the virus in the circulatory system have been reported to decrease by more than 10 super(9)pfu within 48h of intraperitoneal intravenous or oral administration. Based on these observations, serial passage techniques have been used to select lambda phage mutants, with 13,000-16,000-fold greater capacity to remain in the mouse circulatory system 24h after intraperitoneal injection. In these prior studies the ''long-circulating'' phage, designated lambda Argo phage, had at least three mutations including one in the major phage capsid (E) protein, which resulted in the change of glutamic acid to a lysine at residue 158. In the current study, we demonstrate that this single specific substitution in the E protein is sufficient to confer the ''long-circulating'' phenotype. The isogenic pair of phage developed in this study consisting of the long-circulating marker-rescued lambda Argo phage, and the parental wild type phage can be used for studies of viral recognition mechanisms of the innate immune system and for the development of more effective antibacterial therapeutic phage strains. JF - Virus Research AU - Vitiello, CL AU - Merril, C R AU - Adhya, S AD - National Institutes of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA, merrilc@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 101 EP - 103 VL - 114 IS - 1-2 SN - 0168-1702, 0168-1702 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Phages KW - Capsids KW - Intravenous administration KW - Amino acid substitution KW - Immune system KW - Oral administration KW - Survival KW - Lysine KW - Antibodies KW - double prime E protein KW - Glutamic acid KW - Mutation KW - Capsid protein KW - Circulatory system KW - V 22070:Phage-host interactions including lysogeny & transduction KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20156733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virus+Research&rft.atitle=An+amino+acid+substitution+in+a+capsid+protein+enhances+phage+survival+in+mouse+circulatory+system+more+than+a+1000-fold&rft.au=Vitiello%2C+CL%3BMerril%2C+C+R%3BAdhya%2C+S&rft.aulast=Vitiello&rft.aufirst=CL&rft.date=2005-12-01&rft.volume=114&rft.issue=1-2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Virus+Research&rft.issn=01681702&rft_id=info:doi/10.1016%2Fj.virusres.2005.05.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Capsids; Phages; Intravenous administration; Amino acid substitution; Immune system; Oral administration; Lysine; Survival; Antibodies; double prime E protein; Glutamic acid; Mutation; Circulatory system; Capsid protein DO - http://dx.doi.org/10.1016/j.virusres.2005.05.014 ER - TY - JOUR T1 - Population Pharmacokinetics of Amphotericin B Lipid Complex in Neonates AN - 19983169; 7139858 AB - The pharmacokinetics of amphotericin B lipid complex (ABLC) were investigated in neonates with invasive candidiasis enrolled in a phase II multicenter trial. Sparse blood (153 samples; 1 to 9 per patient, 1 to 254 h after the dose) and random urine and cerebrospinal fluid (CSF) samples of 28 neonates (median weight [WT], 1.06 kg; range, 0.48 to 4.9 kg; median gestational age, 27 weeks; range, 24 to 41 weeks) were analyzed. Patients received intravenous ABLC at 2.5 (n = 15) or 5 (n = 13) mg/kg of body weight once a day over 1 or 2 h, respectively, for a median of 21 days (range, 4 to 47 days). Concentrations of amphotericin B were quantified as total drug by high-performance liquid chromatography. Blood data for time after dose (TAD) of 24 h revealed a terminal half-life of 395 h. Mean concentrations in the urine after 1, 2, and 3 weeks ranged from 0.082 to 0.430 mu g/ml, and those in CSF ranged from undetectable to 0.074 mu g/ml. The disposition of ABLC in neonates was similar to that observed in other age groups: weight was the only factor that influenced clearance. Based on these results and previously published safety and efficacy data, we recommend a daily dosage between 2.5 and 5.0 mg/kg for treatment of invasive Candida infections in neonates. JF - Antimicrobial Agents & Chemotherapy AU - Wuerthwein, Gudrun AU - Groll, Andreas H AU - Hempel, Georg AU - Adler-Shohet, Felice C AU - Lieberman, Jay M AU - Walsh, Thomas J AD - Infectious Disease Research Program, Center for Bone Marrow Transplantation and Department of Pediatric Hematology/Oncology, Children's University Hospital, Muenster, Federal Republic of Germany. Clinical Pharmacokinetics Section, Coordinating Centre for Clinical Trials (KKS), University Hospital, Muenster, Federal Republic of Germany. Millers Children's Hospital, Long Beach, California. Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 5092 EP - 5098 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 49 IS - 12 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - High-performance liquid chromatography KW - Amphotericin B KW - Intravenous administration KW - Age KW - Gestational age KW - Mathematical models KW - Data processing KW - Candidiasis KW - Lipids KW - Candida KW - Disposition KW - Infection KW - Clinical trials KW - Pharmacokinetics KW - Antimicrobial agents KW - Models KW - Blood KW - Cerebrospinal fluid KW - Body weight KW - Urine KW - Neonates KW - Drugs KW - A 01340:Antibiotics & Antimicrobials KW - K 03400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19983169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Population+Pharmacokinetics+of+Amphotericin+B+Lipid+Complex+in+Neonates&rft.au=Wuerthwein%2C+Gudrun%3BGroll%2C+Andreas+H%3BHempel%2C+Georg%3BAdler-Shohet%2C+Felice+C%3BLieberman%2C+Jay+M%3BWalsh%2C+Thomas+J&rft.aulast=Wuerthwein&rft.aufirst=Gudrun&rft.date=2005-12-01&rft.volume=49&rft.issue=12&rft.spage=5092&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Amphotericin B; Age; Intravenous administration; Data processing; Mathematical models; Gestational age; Candidiasis; Lipids; Disposition; Infection; Clinical trials; Pharmacokinetics; Models; Antimicrobial agents; Blood; Cerebrospinal fluid; Body weight; Urine; Neonates; Drugs; Candida ER - TY - JOUR T1 - The Conserved Poxvirus L3 Virion Protein Is Required for Transcription of Vaccinia Virus Early Genes AN - 19964683; 7144483 AB - We provide the initial characterization of the product of the vaccinia virus L3L open reading frame (VACWR090), which is conserved in all sequenced members of the poxvirus family. The predicted polypeptide contains no motifs or other features that provided a clue to the role of the L3 protein, and no functional information was available regarding a homolog discovered in Plasmodium falciparum. The L3 protein was expressed following viral DNA replication, a finding consistent with a putative late promoter sequence, and was packaged as a non-membrane protein in mature virus particles. A recombinant virus, in which the L3L gene was regulated by the Escherichia coli lac operator/repressor system, had a conditional lethal phenotype. The virus replicated in the presence of inducer, but in its absence, the yields of infectious virus were reduced by 99%. When cells were infected without inducer, however, no defect in gene expression or morphogenesis was noted. Virus particles lacking L3, which assembled in the absence of inducer, were indistinguishable from wild-type virions with regard to morphology, major structural proteins, and DNA content but were noninfectious. L3-deficient virions were able to bind and penetrate cells but produced extremely small amounts of viral early mRNA. A defect in transcription was demonstrated by in vitro studies with permeabilized virions, but soluble extracts of L3-deficient virions showed normal levels of template-dependent transcriptional activity, indicating that only transcription of the packaged genome is impaired. JF - Journal of Virology AU - Resch, Wolfgang AU - Moss, Bernard AD - Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2005/12/01/ PY - 2005 DA - 2005 Dec 01 SP - 14719 EP - 14729 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 79 IS - 23 SN - 0022-538X, 0022-538X KW - Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Virions KW - Genomes KW - DNA biosynthesis KW - Replication KW - Nucleotide sequence KW - Morphogenesis KW - Transcription KW - Plasmodium falciparum KW - Structural proteins KW - Operators KW - Promoters KW - Vaccinia virus KW - Poxvirus KW - Escherichia coli KW - Repressors KW - Open reading frames KW - N 14820:DNA Metabolism & Structure KW - J 02320:Cell Biology KW - G 07770:Bacteria KW - V 22310:Genetics, Taxonomy & Structure KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19964683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=The+Conserved+Poxvirus+L3+Virion+Protein+Is+Required+for+Transcription+of+Vaccinia+Virus+Early+Genes&rft.au=Resch%2C+Wolfgang%3BMoss%2C+Bernard&rft.aulast=Resch&rft.aufirst=Wolfgang&rft.date=2005-12-01&rft.volume=79&rft.issue=23&rft.spage=14719&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Operators; Genomes; Virions; DNA biosynthesis; Promoters; Replication; Nucleotide sequence; Morphogenesis; Transcription; Repressors; Structural proteins; Open reading frames; Vaccinia virus; Poxvirus; Escherichia coli; Plasmodium falciparum ER - TY - JOUR T1 - Lack of Dendritic Cell Maturation Following Infection by Coxiella burnetii Synthesizing Different Lipopolysaccharide Chemotypes AN - 19939656; 6715708 AB - Coxiella burnetii is an obligate intracellular bacterium and the etiologic agent of the zoonotic disease Q fever. Symptomatic infection is normally characterized by flu-like symptoms; however, in some cases, a persistent infection can ensue that may reactivate months or years after initial exposure to cause chronic disease. The mechanisms by which this obligate parasite evades clearance by the host immune response during persistent infection are unknown. We have previously demonstrated that lipopolysaccharide (LPS) length is critical in determining the response of human dendritic cells (DC) to C. burnetii. Here, we investigated whether LPS chemotype affects DC maturation or activation. Immature human DC were infected with three virulent strains of C. burnetii (Nine Mile phase I, S, or Priscilla) that produce chemically distinct LPS molecules. None of these strains stimulated significant upregulation of cell surface markers of DC maturation. Moreover, these strains were equally deficient in inducing DC IL-12p70 production or p38 mitogen-activated protein kinase phosphorylation. Infection of DC by virulent C. burnetii without stimulating significant maturation or inflammatory cytokine production may be a mechanism of immune evasion that results in persistent infection of an otherwise immunocompetent host. Our data indicate that LPS chemotype is not a determinant of DC maturation or cytokine production in response to C. burnetii. JF - Annals of the New York Academy of Sciences AU - Shannon, Jeffrey G AU - Howe, Dale AU - Heinzen, Robert A AD - Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 154 EP - 160 PB - New York Academy of Sciences, 2 East 63rd Street New York NY 10021 USA, [mailto:publications@nyas.org], [URL:http://www.nyas.org] VL - 1063 SN - 0077-8923, 0077-8923 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Parasites KW - Cell surface KW - MAP kinase KW - Data processing KW - double prime Q fever KW - Persistent infection KW - Cell activation KW - Inflammation KW - Coxiella burnetii KW - Interleukin 12 KW - Dendritic cells KW - Phosphorylation KW - Chronic infection KW - Cytokines KW - Lipopolysaccharides KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19939656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Lack+of+Dendritic+Cell+Maturation+Following+Infection+by+Coxiella+burnetii+Synthesizing+Different+Lipopolysaccharide+Chemotypes&rft.au=Shannon%2C+Jeffrey+G%3BHowe%2C+Dale%3BHeinzen%2C+Robert+A&rft.aulast=Shannon&rft.aufirst=Jeffrey&rft.date=2005-12-01&rft.volume=1063&rft.issue=&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell surface; Parasites; MAP kinase; Data processing; Persistent infection; double prime Q fever; Inflammation; Cell activation; Dendritic cells; Interleukin 12; Phosphorylation; Chronic infection; Lipopolysaccharides; Cytokines; Coxiella burnetii ER - TY - JOUR T1 - BMP2 and FGF2 cooperate to induce neural-crest-like fates from fetal and adult CNS stem cells AN - 19931233; 6577582 AB - CNS stem cells are best characterized by their ability to self-renew and to generate multiple differentiated derivatives, but the effect of mitogenic signals, such as fibroblast growth factor 2 (FGF2), on the positional identity of these cells is not well understood. Here, we report that bone morphogenetic protein 2 (BMP2) induces telencephalic CNS stem cells to fates characteristic of neural crest and choroid plexus mesenchyme, a cell type of undetermined lineage in rodents. This induction occurs both in dissociated cell culture and cortical explants of embryonic day 14.5 (E14.5) embryos, but only when cells have been exposed to FGF2. Neither EGF nor IGF1 can substitute for FGF2. An early step in this response is activation of beta -catenin, a mediator of Wnt activity. The CNS stem cells first undergo an epithelial-to-mesenchymal transition and subsequently differentiate to smooth-muscle and non-CNS glia cells. Similar responses are seen with stem cells from E14.5 cortex, E18.5 cortex and adult subventricular zone, but with a progressive shift toward gliogenesis that is characteristic of normal development. These data indicate that FGF2 confers competence for dorsalization independently of its mitogenic action. This rapid and efficient induction of dorsal fates may allow identification of positional identity effectors that are co-regulated by FGF2 and BMP2. JF - Journal of Cell Science AU - Sailer, Martin HM AU - Hazel, Thomas G AU - Panchision, David M AU - Hoeppner, Daniel J AU - Schwab, Martin E AU - McKay, Ronald DG AD - Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland. Department of Biology, Swiss Federal Institute of Technology, 8057 Zurich, Switzerland. Center for Neuroscience Research, Children's Research Institute, Children's National Medical Center, Washington DC, 20010, USA Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 5849 EP - 5860 PB - Company of Biologists, 140 Cowley Road Cambridge CB4 0DL UK, [URL:http://www.biologists.com/web/index.html] VL - 118 IS - 24 SN - 0021-9533, 0021-9533 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Smooth muscle KW - Central nervous system KW - Insulin-like growth factor I KW - Wnt protein KW - Data processing KW - subventricular zone KW - Cell culture KW - Choroid plexus KW - Fetuses KW - Stem cells KW - catenin KW - Glia KW - Telencephalon KW - Embryos KW - Bone morphogenetic protein 2 KW - Epidermal growth factor KW - Mesenchyme KW - Fibroblast growth factor 2 KW - Explants KW - Neural crest KW - Gliogenesis KW - N3 11070:Neurochemistry and cellular biology KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19931233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cell+Science&rft.atitle=BMP2+and+FGF2+cooperate+to+induce+neural-crest-like+fates+from+fetal+and+adult+CNS+stem+cells&rft.au=Sailer%2C+Martin+HM%3BHazel%2C+Thomas+G%3BPanchision%2C+David+M%3BHoeppner%2C+Daniel+J%3BSchwab%2C+Martin+E%3BMcKay%2C+Ronald+DG&rft.aulast=Sailer&rft.aufirst=Martin&rft.date=2005-12-01&rft.volume=118&rft.issue=24&rft.spage=5849&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cell+Science&rft.issn=00219533&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Smooth muscle; Insulin-like growth factor I; Central nervous system; Data processing; Wnt protein; subventricular zone; Cell culture; Choroid plexus; Fetuses; Stem cells; catenin; Glia; Embryos; Telencephalon; Bone morphogenetic protein 2; Fibroblast growth factor 2; Mesenchyme; Epidermal growth factor; Explants; Gliogenesis; Neural crest ER - TY - JOUR T1 - Crystal structure of human T cell leukemia virus protease, a novel target for anticancer drug design AN - 19924921; 6578666 AB - The successful development of a number of HIV-1 protease (PR) inhibitors for the treatment of AIDS has validated the utilization of retroviral PRs as drug targets and necessitated their detailed structural study. Here we report the structure of a complex of human T cell leukemia virus type 1 (HTLV-1) PR with a substrate-based inhibitor bound in subsites P5 through P5'. Although HTLV-1 PR exhibits an overall fold similar to other retroviral PRs, significant structural differences are present in several loop areas, which include the functionally important flaps, previously considered to be structurally highly conserved. Potential key residues responsible for the resistance of HTLV-1 PR to anti-HIV drugs are identified. We expect that the knowledge accumulated during the development of anti-HIV drugs, particularly in overcoming drug resistance, will help in designing a novel class of antileukemia drugs targeting HTLV-1 PR and in predicting their drug-resistance profile. The structure presented here can be used as a starting point for the development of such anticancer therapies. JF - Proceedings of the National Academy of Sciences, USA AU - Li, Mi AU - Laco, Gary S AU - Jaskolski, Mariusz AU - Rozycki, Jan AU - Alexandratos, Jerry AU - Wlodawer, Alexander AU - Gustchina, Alla AD - Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, MD 21702 Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 18332 EP - 18337 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 102 IS - 51 SN - 0027-8424, 0027-8424 KW - HIV-1 KW - Biotechnology and Bioengineering Abstracts; Oncogenes & Growth Factors Abstracts; Virology & AIDS Abstracts KW - Drug delivery KW - Acquired immune deficiency syndrome KW - Human immunodeficiency virus KW - Drug resistance KW - Human T-lymphotropic virus 1 KW - Human immunodeficiency virus 1 KW - Proteinase inhibitors KW - Lymphocytes T KW - Crystal structure KW - Drug development KW - Proteinase KW - V 22032:Viral proteins KW - W 30915:Pharmaceuticals & Vaccines KW - B 26285:Retroviruses UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19924921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Crystal+structure+of+human+T+cell+leukemia+virus+protease%2C+a+novel+target+for+anticancer+drug+design&rft.au=Li%2C+Mi%3BLaco%2C+Gary+S%3BJaskolski%2C+Mariusz%3BRozycki%2C+Jan%3BAlexandratos%2C+Jerry%3BWlodawer%2C+Alexander%3BGustchina%2C+Alla&rft.aulast=Li&rft.aufirst=Mi&rft.date=2005-12-01&rft.volume=102&rft.issue=51&rft.spage=18332&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Drug delivery; Acquired immune deficiency syndrome; Drug resistance; Proteinase inhibitors; Crystal structure; Lymphocytes T; Proteinase; Drug development; Human immunodeficiency virus; Human immunodeficiency virus 1; Human T-lymphotropic virus 1 ER - TY - JOUR T1 - Potent Antiviral Activity of North-Methanocarbathymidine against Kaposi's Sarcoma-Associated Herpesvirus AN - 19839571; 7139840 AB - Kaposi's sarcoma-associated herpesvirus (KSHV) infection is a prerequisite for the development of Kaposi's sarcoma (KS). Blocking lytic KSHV replication may hinder KS tumorigenesis. Here, we report potent in vitro anti-KSHV activity of 2'-exo-methanocarbathymidine [North-methanocarbathymidine (N-MCT)], a thymidine analog with a pseudosugar ring locked in the northern conformation, which has previously been shown to block the replication of herpes simplex virus types 1 and 2. N-MCT inhibited KSHV virion production in lytically induced KSHV-infected BCBL-1 cells with a substantially lower 50% inhibitory concentration (IC sub(50)) than those of cidofovir (CDV) and ganciclovir (GCV) (IC sub(50), mean plus or minus standard deviation: 0.08 plus or minus 0.03, 0.42 plus or minus 0.07, and 0.96 plus or minus 0.49 mu M for N-MCT, CDV, and GCV, respectively). The reduction in KSHV virion production was accompanied by a corresponding decrease in KSHV DNA levels in the N-MCT-treated BCBL-1 cells, indicating that the compound blocked lytic KSHV DNA replication. A time- and dose-dependent accumulation of N-MCT-triphosphate (TP) was demonstrated in lytically induced BCBL-1 cells, while uninfected cells showed virtually no accumulation. The levels of N-MCT-TP were significantly decreased in the presence of 5'-ethynylthymidine, a potent inhibitor of herpesvirus thymidine kinase, resulting in the abrogation of anti-KSHV activity of N-MCT. N-MCT-TP more effectively blocked in vitro DNA synthesis by KSHV DNA polymerase with an IC sub(50) of 6.24 plus or minus 0.08 mu M (mean plus or minus standard deviation) compared to CDV-diphosphate (14.70 plus or minus 2.47 mu M) or GCV-TP (24.59 plus or minus 5.60 mu M). Taken together, N-MCT is a highly potent and target-specific anti-KSHV agent which inhibits lytic KSHV DNA synthesis through its triphosphate metabolite produced in KSHV-infected cells expressing a virally encoded thymidine kinase. JF - Antimicrobial Agents & Chemotherapy AU - Zhu, Weimin AU - Burnette, Angela AU - Dorjsuren, Dorjbal AU - Roberts, Paula E AU - Huleihel, Mahmoud AU - Shoemaker, Robert H AU - Marquez, Victor E AU - Agbaria, Riad AU - Sei, Shizuko AD - Laboratory of Antiviral Drug Mechanisms, SAIC-Frederick, Frederick, Maryland. National Institute for Biotechnology and Department of Virology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. Screening Technologies Branch, Developmental Therapeutics Program, NCI-Frederick, Frederick, Maryland. Laboratory of Medicinal Chemistry, Center for Cancer Research, NCI-Frederick, Frederick, Maryland. Department of Clinical Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 4965 EP - 4973 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 49 IS - 12 SN - 0066-4804, 0066-4804 KW - HSV KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Cidofovir KW - Virions KW - DNA biosynthesis KW - Human herpesvirus 8 KW - Replication KW - Tumorigenesis KW - Kaposi's sarcoma-associated herpesvirus KW - Metabolites KW - Ganciclovir KW - Thymidine kinase KW - Infection KW - Antiviral activity KW - Antimicrobial agents KW - Standard deviation KW - Kaposi's sarcoma KW - DNA-directed DNA polymerase KW - Herpes simplex virus KW - Thymidine KW - Conformation KW - A 01340:Antibiotics & Antimicrobials KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19839571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Potent+Antiviral+Activity+of+North-Methanocarbathymidine+against+Kaposi%27s+Sarcoma-Associated+Herpesvirus&rft.au=Zhu%2C+Weimin%3BBurnette%2C+Angela%3BDorjsuren%2C+Dorjbal%3BRoberts%2C+Paula+E%3BHuleihel%2C+Mahmoud%3BShoemaker%2C+Robert+H%3BMarquez%2C+Victor+E%3BAgbaria%2C+Riad%3BSei%2C+Shizuko&rft.aulast=Zhu&rft.aufirst=Weimin&rft.date=2005-12-01&rft.volume=49&rft.issue=12&rft.spage=4965&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Virions; Cidofovir; DNA biosynthesis; Replication; Tumorigenesis; Thymidine kinase; Ganciclovir; Metabolites; Antiviral activity; Infection; Antimicrobial agents; Standard deviation; Kaposi's sarcoma; DNA-directed DNA polymerase; Thymidine; Conformation; Human herpesvirus 8; Kaposi's sarcoma-associated herpesvirus; Herpes simplex virus ER - TY - JOUR T1 - Enzymatic Redesigning of Biologically Active Heparan Sulfate AN - 19825825; 6577430 AB - Heparan sulfate carries a wide range of biological activities, regulating blood coagulation, cell differentiation, and inflammatory responses. The sulfation patterns of the polysaccharide are essential for the biological activities. In this study, we report an enzymatic method for the sulfation of multimilligram amounts of heparan sulfate with specific functions using immobilized sulfotransferases combined with a 3'-phosphoadenosine 5'-phosphosulfate regeneration system. By selecting appropriate enzymatic modification steps, an inactive precursor has been converted to the heparan sulfate having three distinct biological activities, associated with binding to antithrombin, fibroblast growth factor-2, and herpes simplex virus envelope glycoprotein D. Because the recombinant sulfotransferases are expressed in bacteria, and the method uses a low cost sulfo donor, it can be readily utilized to synthesize large quantities of anticoagulant heparin drug or other biologically active heparan sulfates. JF - Journal of Biological Chemistry AU - Chen, Jinghua AU - Avci, Fikri Y AU - Munoz, Eva M AU - McDowell, Lynda M AU - Chen, Miao AU - Pedersen, Lars C AU - Zhang, Lijuan AU - Linhardt, Robert J AU - Liu, Jian AD - Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, the Department of Chemistry and Chemical Biology, Biology and Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, the Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, and the Laboratory of Structural Biology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709 Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 42817 EP - 42825 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 280 IS - 52 SN - 0021-9258, 0021-9258 KW - HSV KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Anticoagulants KW - Sulfotransferase KW - Polysaccharides KW - Heparan sulfate KW - Inflammation KW - glycoprotein D KW - Differentiation KW - Blood coagulation KW - Envelopes KW - Fibroblast growth factor 2 KW - Herpes simplex virus KW - Drugs KW - Heparin KW - antithrombin KW - W 30965:Miscellaneous, Reviews KW - V 22310:Genetics, Taxonomy & Structure KW - W3 33390:Products: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19825825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Enzymatic+Redesigning+of+Biologically+Active+Heparan+Sulfate&rft.au=Chen%2C+Jinghua%3BAvci%2C+Fikri+Y%3BMunoz%2C+Eva+M%3BMcDowell%2C+Lynda+M%3BChen%2C+Miao%3BPedersen%2C+Lars+C%3BZhang%2C+Lijuan%3BLinhardt%2C+Robert+J%3BLiu%2C+Jian&rft.aulast=Chen&rft.aufirst=Jinghua&rft.date=2005-12-01&rft.volume=280&rft.issue=52&rft.spage=42817&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Sulfotransferase; Anticoagulants; Polysaccharides; Heparan sulfate; glycoprotein D; Inflammation; Differentiation; Blood coagulation; Envelopes; Fibroblast growth factor 2; Heparin; Drugs; antithrombin; Herpes simplex virus ER - TY - JOUR T1 - A Role for TLRs in the Regulation of Immune Cell Migration by First Trimester Trophoblast Cells AN - 19820311; 6577908 AB - Normal pregnancy is characterized by the presence of innate immune cells at the maternal-fetal interface. Originally, it was postulated that the presence of these leukocytes was due to an immune response toward paternal Ags expressed by the invading trophoblasts. Instead, we and others postulate that these innate immune cells are necessary for successful implantation and pregnancy. However, elevated leukocyte infiltration may be an underlying cause of pregnancy complications, such as preterm labor or preeclampsia. Furthermore, such conditions have been attributed to an intrauterine infection. Therefore, we hypothesize that first trimester trophoblast cells, upon recognition of microbes through TLRs, may coordinate an immune response by recruiting cells of the innate immune system to the maternal-fetal interface. In this study, we have demonstrated that human first trimester trophoblast cells constitutively secrete the chemokines growth-related oncogene, growth-related oncogene alpha , IL-8, and MCP-1 and are able to recruit monocytes and NK cells, and to a lesser degree, neutrophils. Following the ligation of TLR-3 by the viral ligand, poly(I:C), or TLR-4 by bacterial LPS, trophoblast secretion of chemokines is significantly increased and this in turn results in elevated monocyte and neutrophil chemotaxis. In addition, TLR-3 stimulation also induces trophoblast cells to secrete RANTES. These results suggest a novel mechanism by which first trimester trophoblast cells may differentially modulate the maternal immune system during normal pregnancy and in the presence of an intrauterine infection. Such altered trophoblast cell responses might contribute to the pathogenesis of certain pregnancy complications. JF - Journal of Immunology AU - Abrahams, Vikki M AU - Visintin, Irene AU - Aldo, Paulomi B AU - Guller, Seth AU - Romero, Roberto AU - Mor, Gil AD - Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520. Perinatology Research Branch, National Institute of Child Health and Human Development, Detroit, MI 48202 Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 8096 EP - 8104 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 175 IS - 12 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Chemokines KW - Monocyte chemoattractant protein 1 KW - Immune system KW - Leukocytes (neutrophilic) KW - Natural killer cells KW - Trophoblasts KW - RANTES KW - Infection KW - Chemotaxis KW - Interleukin 8 KW - Pregnancy KW - Gro protein KW - Pregnancy complications KW - Pre-eclampsia KW - Lipopolysaccharides KW - Immune response KW - Monocytes KW - Cell migration KW - V 22350:Immunology KW - J 02350:Immunology KW - F 06378:Reproductive System: Clinical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19820311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=A+Role+for+TLRs+in+the+Regulation+of+Immune+Cell+Migration+by+First+Trimester+Trophoblast+Cells&rft.au=Abrahams%2C+Vikki+M%3BVisintin%2C+Irene%3BAldo%2C+Paulomi+B%3BGuller%2C+Seth%3BRomero%2C+Roberto%3BMor%2C+Gil&rft.aulast=Abrahams&rft.aufirst=Vikki&rft.date=2005-12-01&rft.volume=175&rft.issue=12&rft.spage=8096&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-01-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Chemokines; Monocyte chemoattractant protein 1; Immune system; Natural killer cells; Leukocytes (neutrophilic); RANTES; Trophoblasts; Infection; Chemotaxis; Interleukin 8; Pregnancy; Pregnancy complications; Gro protein; Pre-eclampsia; Lipopolysaccharides; Cell migration; Monocytes; Immune response ER - TY - JOUR T1 - Invasive Infections with Haemophilus influenzae Serotype a Containing an IS1016-bexA Partial Deletion: Possible Association with Virulence AN - 19773333; 6841846 AB - Recent reports of invasive Haemophilus influenzae non-b capsular serotypes in the era since development of conjugate vaccines have prompted concern about serotype replacement. Unusual clusters of invasive infection due to H. influenzae serotype a with clinical features that resemble those of infection due to H. influenzae serotype b have been described. A unique feature often associated with more-virulent H. influenzae serotype a isolates is the IS1016-bexA partial deletion, which was previously identified in the capsule locus of H. influenzae serotype b strains. We report the clinical, epidemiologic, and molecular genetic features of 2 cases of severe disease caused by H. influenzae serotype a. Invasive H. influenzae isolates were serotyped with standard serological methods, and molecular typing was done with PCR. The capsular genotype of each isolate was characterized with PCR, partial sequencing, and Southern blot hybridization. Further strain typing was performed with pulsed-field gel electrophoresis. We identified 2 children with severe invasive disease due to H. influenzae serotype a. Both H. influenzae serotype a isolates contained the identical pulsed-field gel electrophoresis pattern and capsular genotype. An IS1016-bexA partial deletion in the capsule gene locus similar to that found in H. influenzae serotype b was identified in both isolates by means of PCR and sequencing of the IS1016-bexA junction. We describe 2 cases of severe invasive disease due to H. influenzae serotype a with the putative virulence-enhancing IS1016-bexA partial deletion and duplication of the capsule locus. Our data support the hypothesis that this mutation may be associated with virulence in non-b capsular serotypes of H. influenzae. JF - Clinical Infectious Diseases AU - Kapogiannis, B G AU - Satola, S AU - Keyserling, H L AU - Farley, M M AD - Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA Y1 - 2005/12/01/ PY - 2005 DA - 2005 Dec 01 SP - e97 EP - e103 VL - 41 IS - 11 SN - 1058-4838, 1058-4838 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology KW - Haemophilus influenzae KW - Serotypes KW - Data processing KW - Genotypes KW - Children KW - Infection KW - Virulence KW - Gene deletion KW - Typing KW - Pulsed-field gel electrophoresis KW - Polymerase chain reaction KW - Vaccines KW - Mutation KW - J 02834:Vaccination and immunization KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19773333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Invasive+Infections+with+Haemophilus+influenzae+Serotype+a+Containing+an+IS1016-bexA+Partial+Deletion%3A+Possible+Association+with+Virulence&rft.au=Kapogiannis%2C+B+G%3BSatola%2C+S%3BKeyserling%2C+H+L%3BFarley%2C+M+M&rft.aulast=Kapogiannis&rft.aufirst=B&rft.date=2005-12-01&rft.volume=41&rft.issue=11&rft.spage=e97&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Virulence; Gene deletion; Data processing; Typing; Serotypes; Pulsed-field gel electrophoresis; Polymerase chain reaction; Vaccines; Genotypes; Infection; Children; Mutation; Haemophilus influenzae ER - TY - JOUR T1 - Cancer Incidence among Male Pesticide Applicators in the Agricultural Health Study Cohort Exposed to Diazinon AN - 19772670; 7140979 AB - Little is known about the potential carcinogenicity associated with routine application of diazinon, a common organophosphate insecticide. The authors explored a possible association of diazinon exposure with cancer risk in the Agricultural Health Study, a prospective cohort of licensed pesticide applicators in Iowa and North Carolina enrolled in 1993-1997. A total of 23,106 male applicators provided information in a self-administered questionnaire. Among 4,961 applicators who reported using diazinon, 301 incident cancer cases were diagnosed during the follow-up period ending December 2002 compared with 968 cases among 18,145 participants who reported no use. Poisson regression was used to calculate rate ratios and 95% confidence intervals. Two quantitative exposure metrics were used: lifetime exposure days and intensity-weighted lifetime exposure days, a measure that incorporates probability of pesticide exposure with lifetime pesticide application frequency. When lifetime exposure days were used, increased risks for the highest tertile of exposure and significant tests for trend for lung cancer and leukemia were observed. No other cancer site showed an association with diazinon for the highest tertile of exposure. Because these results were based on small numbers, additional analyses are necessary as more cases accrue to clarify whether diazinon is associated with cancer risk in humans. JF - American Journal of Epidemiology AU - Beane Freeman, Laura E AU - Bonner, Matthew R AU - Blair, Aaron AU - Hoppin, Jane A AU - Sandler, Dale P AU - Lubin, Jay H AU - Dosemeci, Mustafa AU - Lynch, Charles F AU - Knott, Charles AU - Alavanja, Michael CR AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD Y1 - 2005/12/01/ PY - 2005 DA - 2005 Dec 01 SP - 1070 EP - 1079 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 162 IS - 11 SN - 0002-9262, 0002-9262 KW - Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Agriculture KW - USA, North Carolina KW - Inventories KW - Organophosphates KW - males KW - organophosphates KW - Cancer KW - Pesticide applications KW - Leukemia KW - Insecticides KW - USA, Iowa KW - Carcinogenicity KW - Risk factors KW - Pesticides KW - Diazinon KW - Occupational exposure KW - Lung cancer KW - H 5000:Pesticides KW - R2 23060:Medical and environmental health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19772670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Cancer+Incidence+among+Male+Pesticide+Applicators+in+the+Agricultural+Health+Study+Cohort+Exposed+to+Diazinon&rft.au=Beane+Freeman%2C+Laura+E%3BBonner%2C+Matthew+R%3BBlair%2C+Aaron%3BHoppin%2C+Jane+A%3BSandler%2C+Dale+P%3BLubin%2C+Jay+H%3BDosemeci%2C+Mustafa%3BLynch%2C+Charles+F%3BKnott%2C+Charles%3BAlavanja%2C+Michael+CR&rft.aulast=Beane+Freeman&rft.aufirst=Laura&rft.date=2005-12-01&rft.volume=162&rft.issue=11&rft.spage=1070&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Inventories; Leukemia; Insecticides; Carcinogenicity; Risk factors; Pesticides; organophosphates; Diazinon; Pesticide applications; Lung cancer; Agriculture; Organophosphates; males; Occupational exposure; Cancer; USA, North Carolina; USA, Iowa ER - TY - JOUR T1 - A review of evidence from short-term studies leading to the prediction that diazoaminobenzene (1,3-diphenyltriazine) is a carcinogen AN - 19727108; 7516658 AB - The National Toxicology Program (NTP) is responsible for providing comprehensive toxicology evaluations of substances, while at the same time incorporating approaches to reduce, refine or replace laboratory animals in routine toxicity/carcinogenicity studies. Consistent with this, a series of metabolism studies in rodents and human liver slices, electron spin resonance spectroscopy (ESR) studies, short-term dermal toxicity studies in rodents, and acute bone marrow micronucleus studies in mice were performed on diazoaminobenzene (DAAB, also known as 1,3-diphenyltriazine). These studies demonstrated that DAAB is metabolized and shares similar genotoxic and toxicological properties to the known human carcinogen, benzene, and the known rodent carcinogen, aniline. These data were used to evaluate the potential carcinogenicity of DAAB without doing a 2-year rodent bioassay. Based on this analysis, DAAB was predicted to be carcinogenic if evaluated in a 2-year rodent bioassay. These data were evaluated to support listing DAAB in the NTP Report on Carcinogens as a substance reasonably anticipated to be a human carcinogen. The purpose of this article is to review the data developed for predicting the carcinogenicity of DAAB. Published in 2005 by John Wiley & Sons, Ltd. JF - Journal of Applied Toxicology AU - Bordelon, Nancy R AU - Chhabra, Rajendra AU - Bucher, John R AD - National Toxicology Program, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA, bucher@niehs.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 514 EP - 521 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 25 IS - 6 SN - 0260-437X, 0260-437X KW - Toxicology Abstracts KW - Skin KW - Genotoxicity KW - Laboratory animals KW - Bone marrow KW - Toxicity KW - Carcinogens KW - Spectroscopy KW - Benzene KW - Carcinogenicity KW - Reviews KW - Liver KW - Metabolism KW - Aniline KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19727108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=A+review+of+evidence+from+short-term+studies+leading+to+the+prediction+that+diazoaminobenzene+%281%2C3-diphenyltriazine%29+is+a+carcinogen&rft.au=Bordelon%2C+Nancy+R%3BChhabra%2C+Rajendra%3BBucher%2C+John+R&rft.aulast=Bordelon&rft.aufirst=Nancy&rft.date=2005-12-01&rft.volume=25&rft.issue=6&rft.spage=514&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.1087 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Skin; Genotoxicity; Bone marrow; Laboratory animals; Carcinogens; Toxicity; Spectroscopy; Benzene; Carcinogenicity; Reviews; Liver; Metabolism; Aniline DO - http://dx.doi.org/10.1002/jat.1087 ER - TY - JOUR T1 - n-Alkyl glucopyranosides completely inhibit ultrasound-induced cytolysis AN - 19467651; 7983929 AB - The mechanism(s) responsible for sudden cytolysis observed when cells are exposed to ultrasound could be mechanical and/or free radical in nature. Free radical reactions are initiated in the core and in the interfacial regions of collapsing acoustic cavitation bubbles. Because cyclic sugars are known to inhibit free radical chain reactions, we investigated the effects of n-alkyl- beta -d-glucopyranosides of varying hydrophobicity on ultrasound (1.057 MHz)-induced cytolysis of HL-60 cells in vitro. n-Alkyl glucopyranosides with hexyl- (5 mM), heptyl- (3 mM), or octyl- (2 mM) n-alkyl chains protected 100% of the cell population from ultrasound-induced cytolysis under a range of conditions that resulted in 35 to 100% cytolysis in the absence of glucopyranosides. The protected cell populations also possessed long-term reproductive viability. However, the hydrophilic methyl- beta -d-glucopyranoside could not protect cells, even up to a concentration of 30 mM. Furthermore, none of the glucopyranosides could prevent cytolysis of cells from a mechanically induced shear stress. Spin trapping and electron spin resonance experiments confirmed the presence of inertial cavitation in cell suspensions both in the presence and in the absence of the surfactants. It is concluded that surface-active glucopyranosides efficiently quench cytotoxic radicals and/or their precursors at the gas/solution interface of collapsing cavitation bubbles. JF - Free Radical Biology and Medicine AU - Sostaric, Joe Z AU - Miyoshi, Norio AU - Riesz, Peter AU - Degraff, William G AU - Mitchell, James B AD - Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1002, USA, sostaric.2@osu.edu Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1539 EP - 1548 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 39 IS - 12 SN - 0891-5849, 0891-5849 KW - Biotechnology and Bioengineering Abstracts KW - Free radicals KW - EKW ESR KW - Sonoporation KW - Sonophoresis KW - Sonochemistry KW - Radiolysis KW - HIFU KW - Ultrasound KW - Surfactants KW - HL-60 KW - Protection KW - Sonoprotection KW - Cytolysis KW - Sonolysis KW - Sonication KW - Glucopyranoside KW - Sugars KW - Bioreactors KW - Cell suspensions KW - Sugar KW - Acoustics KW - Hydrophobicity KW - Trapping KW - Mechanical stimuli KW - Cytotoxicity KW - Cavitation KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19467651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+Radical+Biology+and+Medicine&rft.atitle=n-Alkyl+glucopyranosides+completely+inhibit+ultrasound-induced+cytolysis&rft.au=Sostaric%2C+Joe+Z%3BMiyoshi%2C+Norio%3BRiesz%2C+Peter%3BDegraff%2C+William+G%3BMitchell%2C+James+B&rft.aulast=Sostaric&rft.aufirst=Joe&rft.date=2005-12-01&rft.volume=39&rft.issue=12&rft.spage=1539&rft.isbn=&rft.btitle=&rft.title=Free+Radical+Biology+and+Medicine&rft.issn=08915849&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2005.07.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cell suspensions; Sugar; Cytotoxicity; Cavitation; Acoustics; Free radicals; Cytolysis; Hydrophobicity; Trapping; Surfactants; Ultrasound; Mechanical stimuli DO - http://dx.doi.org/10.1016/j.freeradbiomed.2005.07.020 ER - TY - JOUR T1 - Arginine-rich cell penetrating peptides: from endosomal uptake to nuclear delivery AN - 19440765; 6706627 AB - Delivery of macromolecules into living cells by arginine-rich cell penetrating peptides (AR-CPPs) is an important new avenue for the development of novel therapeutic strategies. However, to date the mechanism of this delivery remains elusive. Recent data implicate endocytosis in the internalization of AR-CPPs and their macromolecular cargo and also indicate limited delivery of macromolecules into the cell cytoplasm and nucleus. Different types of endocytosis - clathrin-dependent endocytosis, raft/caveolin-dependent endocytosis and macropinocytosis - are all implicated in the uptake of AR-CPPs and their cargo into different cells. Cationic AR-CPPs dramatically increase uptake of conjugated molecules through efficient binding to surface proteogly-cans. Whether this increase in binding can assure delivery of a sufficient amount of functionally active macromolecules into the cytoplasm and nucleus or whether there is a specific mechanism by which AR-CPPs facilitate the escape of conjugated cargo from endosomes remains to be understood. JF - Cellular and Molecular Life Sciences AU - Melikov, K AU - Chernomordik, LV AD - Section on Membrane Biology, Laboratory of Cellular and Molecular Biophysics, NICHD, National Institutes of Health, Bldg.10/Rm.10D05, 10 Center Drive, Bethesda, Maryland 20892-1855 (USA), melikovk@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 2739 EP - 2749 VL - 62 IS - 23 SN - 1420-682X, 1420-682X KW - Biotechnology and Bioengineering Abstracts KW - Endocytosis KW - endosomes KW - Macromolecules KW - Cytoplasm KW - Nuclei KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19440765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+and+Molecular+Life+Sciences&rft.atitle=Arginine-rich+cell+penetrating+peptides%3A+from+endosomal+uptake+to+nuclear+delivery&rft.au=Melikov%2C+K%3BChernomordik%2C+LV&rft.aulast=Melikov&rft.aufirst=K&rft.date=2005-12-01&rft.volume=62&rft.issue=23&rft.spage=2739&rft.isbn=&rft.btitle=&rft.title=Cellular+and+Molecular+Life+Sciences&rft.issn=1420682X&rft_id=info:doi/10.1007%2Fs00018-005-5293-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Endocytosis; Macromolecules; Nuclei; Cytoplasm; endosomes DO - http://dx.doi.org/10.1007/s00018-005-5293-y ER - TY - JOUR T1 - Finding New Tricks For Old Drugs: An Efficient Route For Public-Sector Drug Discovery AN - 19427848; 6702402 AB - With the annotation of the human genome approaching completion, public- sector researchers-spurred in part by various National Institutes of Health Roadmap Initiatives-have become increasingly engaged in drug discovery and development efforts. Although large and diverse chemical libraries of 'drug- like' compounds can be readily screened to yield chemically novel scaffolds, transforming these 'chemical probes' into drugs is a daunting endeavour. A more efficient approach involves screening libraries of approved and off-patent medications; both phenotypic- and molecular target-based screening of 'old drugs' can readily yield compounds that could be immediately used in clinical trials. Using case studies, we describe how this approach has rapidly identified candidate medications suitable for clinical trials in disorders such as progressive multifocal leukoencephalopathy and amyotrophic lateral sclerosis. This approach has also led to the discovery of the molecular targets responsible for serious drug side effects, thereby allowing efficient 'counter-screening' to avoid these side effects. JF - Nature Reviews: Drug Discovery AU - O'Connor, Kerry A AU - Roth, Bryan L AD - Departments of Biochemistry, Psychiatry, Neurosciences, Comprehensive Cancer Center and National Institute of Mental Health Psychoactive Drug Screening Program, 2109 Adelbert Road, Case Western Reserve University Medical School, Cleveland, Ohio 44106, USA., bryan.roth@case.edu Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1005 EP - 1014 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 4 IS - 12 SN - 1474-1776, 1474-1776 KW - Biotechnology and Bioengineering Abstracts KW - Genomes KW - Drug discovery KW - Amyotrophic lateral sclerosis KW - DNA probes KW - Reviews KW - Drug screening KW - Progressive multifocal leukoencephalopathy KW - Clinical trials KW - Drugs KW - scaffolds KW - Side effects KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19427848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Drug+Discovery&rft.atitle=Finding+New+Tricks+For+Old+Drugs%3A+An+Efficient+Route+For+Public-Sector+Drug+Discovery&rft.au=O%27Connor%2C+Kerry+A%3BRoth%2C+Bryan+L&rft.aulast=O%27Connor&rft.aufirst=Kerry&rft.date=2005-12-01&rft.volume=4&rft.issue=12&rft.spage=1005&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Drug+Discovery&rft.issn=14741776&rft_id=info:doi/10.1038%2Fnrd1900 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Drugs; Drug discovery; Side effects; Clinical trials; Reviews; Genomes; Drug screening; Progressive multifocal leukoencephalopathy; Amyotrophic lateral sclerosis; scaffolds; DNA probes DO - http://dx.doi.org/10.1038/nrd1900 ER - TY - JOUR T1 - Staphylococcal Protein A Deletes B-1a and Marginal Zone B Lymphocytes Expressing Human Immunoglobulins: An Immune Evasion Mechanism AN - 19379852; 7144053 AB - Protein A (SpA) of Staphylococcus aureus is endowed with the capacity to interact with the H chain variable region (V sub(H)) of human Abs and to target >40% of B lymphocytes. To investigate whether this property represents a virulence factor and to determine the in vivo consequences of the confrontation of SpA with B lymphocytes, we used transgenic mice expressing fully human Abs. We found that administration of soluble SpA reduces B-1a lymphocytes of the peritoneal cavity and marginal zone B lymphocytes of the spleen, resulting in a markedly deficient type 2 humoral response. Single-cell PCR analysis and sequencing of the Ab V sub(H) gene repertoire revealed a significant reduction of V sub(H)3 super(+) marginal zone B cells. Since the two B lymphocyte subsets targeted are involved in innate immune functions, our data suggest that crippling of humoral immunity by S. aureus represents an immune evasion mechanism that may aggravate recurrent infections. JF - Journal of Immunology AU - Viau, Muriel AU - Longo, Nancy S AU - Lipsky, Peter E AU - Zouali, Moncef AD - Institut National de Sante et de Recherche Medicale Unite 430, Immunopathologie Humaine, Paris, France. National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892 Y1 - 2005/12/01/ PY - 2005 DA - 2005 Dec 01 SP - 7719 EP - 7727 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 175 IS - 11 SN - 0022-1767, 0022-1767 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Data processing KW - virulence factors KW - Lymphocytes B KW - protein A KW - Peritoneum KW - Spleen KW - Transgenic mice KW - Immunity (humoral) KW - Polymerase chain reaction KW - Recurrent infection KW - Immune response KW - Staphylococcus aureus KW - Immune response (humoral) KW - Immunoglobulins KW - Variable region KW - V 22350:Immunology KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19379852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Staphylococcal+Protein+A+Deletes+B-1a+and+Marginal+Zone+B+Lymphocytes+Expressing+Human+Immunoglobulins%3A+An+Immune+Evasion+Mechanism&rft.au=Viau%2C+Muriel%3BLongo%2C+Nancy+S%3BLipsky%2C+Peter+E%3BZouali%2C+Moncef&rft.aulast=Viau&rft.aufirst=Muriel&rft.date=2005-12-01&rft.volume=175&rft.issue=11&rft.spage=7719&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Data processing; virulence factors; Lymphocytes B; protein A; Peritoneum; Spleen; Transgenic mice; Immunity (humoral); Polymerase chain reaction; Recurrent infection; Immune response; Immune response (humoral); Variable region; Immunoglobulins; Staphylococcus aureus ER - TY - JOUR T1 - Plant-Based Vaccine: Mice Immunized with Chloroplast-Derived Anthrax Protective Antigen Survive Anthrax Lethal Toxin Challenge AN - 19379141; 7142842 AB - The currently available human vaccine for anthrax, derived from the culture supernatant of Bacillus anthracis, contains the protective antigen (PA) and traces of the lethal and edema factors, which may contribute to adverse side effects associated with this vaccine. Therefore, an effective expression system that can provide a clean, safe, and efficacious vaccine is required. In an effort to produce anthrax vaccine in large quantities and free of extraneous bacterial contaminants, PA was expressed in transgenic tobacco chloroplasts by inserting the pagA gene into the chloroplast genome. Chloroplast integration of the pagA gene was confirmed by PCR and Southern analysis. Mature leaves grown under continuous illumination contained PA as up to 14.2% of the total soluble protein. Cytotoxicity measurements in macrophage lysis assays showed that chloroplast-derived PA was equal in potency to PA produced in B. anthracis. Subcutaneous immunization of mice with partially purified chloroplast-derived or B. anthracis-derived PA with adjuvant yielded immunoglobulin G titers up to 1:320,000, and both groups of mice survived (100%) challenge with lethal doses of toxin. An average yield of about 150 mg of PA per plant should produce 360 million doses of a purified vaccine free of bacterial toxins edema factor and lethal factor from 1 acre of land. Such high expression levels without using fermenters and the immunoprotection offered by the chloroplast-derived PA should facilitate development of a cleaner and safer anthrax vaccine at a lower production cost. These results demonstrate the immunogenic and immunoprotective properties of plant-derived anthrax vaccine antigen. JF - Infection and Immunity AU - Koya, Vijay AU - Moayeri, Mahtab AU - Leppla, Stephen H AU - Daniell, Henry AD - Department of Molecular Biology and Microbiology, University of Central Florida, Biomolecular Science Building 20, Room 336, Orlando, Florida 32816-2364. Microbial Pathogenesis Section, National Institute of Allergy and Infectious Diseases, NIH, Building 30, Room 303, 30 Convent Dr., Bethesda, Maryland 20892-4349 Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 8266 EP - 8274 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 73 IS - 12 SN - 0019-9567, 0019-9567 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Genomes KW - Macrophages KW - Fermenters KW - Plant protection KW - Lethal factor KW - Edema KW - Adjuvants KW - Bacillus anthracis KW - Transgenic plants KW - Integration KW - Tobacco KW - Anthrax KW - Polymerase chain reaction KW - Anthrax lethal toxin KW - protective antigen KW - Leaves KW - Chloroplasts KW - Immunization KW - Cytotoxicity KW - Illumination KW - Immunogenicity KW - Immunoglobulin G KW - Plants KW - Vaccines KW - Contaminants KW - Side effects KW - Lethal dose KW - X 24380:Social Poisons & Drug Abuse KW - F 06905:Vaccines KW - W 30915:Pharmaceuticals & Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19379141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Plant-Based+Vaccine%3A+Mice+Immunized+with+Chloroplast-Derived+Anthrax+Protective+Antigen+Survive+Anthrax+Lethal+Toxin+Challenge&rft.au=Koya%2C+Vijay%3BMoayeri%2C+Mahtab%3BLeppla%2C+Stephen+H%3BDaniell%2C+Henry&rft.aulast=Koya&rft.aufirst=Vijay&rft.date=2005-12-01&rft.volume=73&rft.issue=12&rft.spage=8266&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Genomes; Fermenters; Plant protection; Lethal factor; Edema; Adjuvants; Transgenic plants; Integration; Tobacco; Polymerase chain reaction; Anthrax; Anthrax lethal toxin; protective antigen; Leaves; Chloroplasts; Immunization; Cytotoxicity; Illumination; Immunogenicity; Plants; Immunoglobulin G; Vaccines; Contaminants; Side effects; Lethal dose; Bacillus anthracis ER - TY - JOUR T1 - Drinking Water and Dietary Sources of Nitrate and Nitrite and Risk of Glioma AN - 17481361; 6677734 AB - Dietary nitrite has been associated with increased glioma risk; however, drinking water nitrate has not been extensively evaluated. We conducted a population-based case-control study of adult glioma in Nebraska. Water utility nitrate measurements were linked to residential water source histories. We computed average nitrate exposure over a 20-year period. A food frequency questionnaire was used to assess dietary nitrate and nitrite. Increasing quartiles of the average nitrate level in drinking water were not significantly associated with risk (adjusted odd ratios: 1.4, 1.2, 1.3). Risk was similar among those with both higher and lower intakes of vitamin C, an inhibitor of N-nitroso compound formation. Dietary nitrite intake was not associated with risk. Our study does not support a role for drinking water and dietary sources of nitrate and nitrite in risk of adult glioma. JF - Journal of Occupational and Environmental Medicine AU - Ward, M H AU - Heineman, E F AU - McComb, R D AU - Weisenburger, D D AD - Occupational and Environmental Epidemiology Branch, National Cancer Institute, 6120 Executive Blvd, EPS-8104, Bethesda, MD 20892-7240, USA, wardm@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1260 EP - 1267 VL - 47 IS - 12 SN - 1076-2752, 1076-2752 KW - glioma KW - Water Resources Abstracts; Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - Nitrate KW - Food KW - Intakes KW - Water quality KW - Dietary intake KW - Utilities KW - Public health KW - Drinking Water KW - History KW - Vitamins KW - Glioma KW - Nitrite KW - Nitrates KW - Ingestion KW - Ascorbic acid KW - Brain tumors KW - Risk KW - Foods KW - N-Nitroso compounds KW - Nitrites KW - USA, Nebraska KW - Drinking water KW - X 24120:Food, additives & contaminants KW - SW 3060:Water treatment and distribution KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17481361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Drinking+Water+and+Dietary+Sources+of+Nitrate+and+Nitrite+and+Risk+of+Glioma&rft.au=Ward%2C+M+H%3BHeineman%2C+E+F%3BMcComb%2C+R+D%3BWeisenburger%2C+D+D&rft.aulast=Ward&rft.aufirst=M&rft.date=2005-12-01&rft.volume=47&rft.issue=12&rft.spage=1260&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2F01.jom.0000184879.67736.ae LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Brain tumors; Nitrate; N-Nitroso compounds; Food; Glioma; Drinking water; Nitrite; Dietary intake; Ascorbic acid; Nitrites; Nitrates; Ingestion; Water quality; Public health; Risk; Foods; Drinking Water; History; Vitamins; Intakes; Utilities; USA, Nebraska DO - http://dx.doi.org/10.1097/01.jom.0000184879.67736.ae ER - TY - JOUR T1 - Metabolism and disposition of juglone in male F344 rats AN - 17474426; 6678353 AB - The metabolism and disposition of super(14)C-labelled juglone in male F344 rats following oral, intravenous and dermal administration were studied. Approximately 40-50% of an oral dose (0.1 to 10 mg kg super(-1)) and less than 20% of the dermal dose (4 mg kg super(-1)) were absorbed within 24 h. Most of the oral dose was excreted in faeces and urine within 24 h and only 1-3% remained in the tissues. High concentrations of juglone-derived radioactivity were found in kidney for all three dosing routes. The accumulation in kidney can be attributed to covalent binding of juglone and/or metabolites to cytosolic protein. Five metabolites were identified in the urine of rats treated with an oral dose: 1,4,5-trihydroxynaphthalene di-glucuronide, 1,4,5-trihydroxynaphthalene mono-glucuronide mono-sulfate, 2-sulfo-2,3-dihydrojuglone, 4,8-dihydroxy-1-tetralone mono-glucuronide and 1,4,5-trihydroxynaphthalene mono-glucuronide. Liver microsomal incubations of juglone in the presence of NAD(P)H and UDP-glucuronic acid gave rise to two 1,4,5-trihydroxynaphthalene mono-glucuronides. JF - Xenobiotica AU - Chen, L-J AU - Lebetkin, E H AU - Burka, L T AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1019 EP - 1034 VL - 35 IS - 10-11 SN - 0049-8254, 0049-8254 KW - Toxicology Abstracts KW - Intravenous administration KW - Skin KW - Urine KW - Kidney KW - Liver KW - Metabolites KW - Disposition KW - Radioactivity KW - Feces KW - Metabolism KW - X 24172:Plants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17474426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenobiotica&rft.atitle=Metabolism+and+disposition+of+juglone+in+male+F344+rats&rft.au=Chen%2C+L-J%3BLebetkin%2C+E+H%3BBurka%2C+L+T&rft.aulast=Chen&rft.aufirst=L-J&rft.date=2005-12-01&rft.volume=35&rft.issue=10-11&rft.spage=1019&rft.isbn=&rft.btitle=&rft.title=Xenobiotica&rft.issn=00498254&rft_id=info:doi/10.1080%2F00498250500356621 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Intravenous administration; Skin; Urine; Liver; Kidney; Disposition; Metabolites; Radioactivity; Feces; Metabolism DO - http://dx.doi.org/10.1080/00498250500356621 ER - TY - JOUR T1 - Resistance and functional training reduces knee extensor position fluctuations in functionally limited older adults AN - 17469256; 6654941 AB - The purpose of this study was to determine the effect of task-specificity on knee extensor steadiness adaptations in functionally limited older adults. Twenty-four functionally limited older adults (74.6 plus or minus 7.6 years: 22 women, 2 men) completed a 10-week control period followed by 10 weeks (2 days/week) of resistance (RT), functional (FT) (practicing everyday tasks, i.e., chair rises) or functional + resistance (FRT) training, which featured both shortening and lengthening movements. During testing, subjects performed a steady isometric [10, 25, 50% of maximal voluntary contraction (MVC)] and shortening/lengthening (5, 30, 65% of MVC) knee extensor contractions. There were no steadiness (isometric, shortening or lengthening contractions) changes in the control period and no adaptations in isometric steadiness due to training. RT induced a 37% reduction in shortening fluctuations at 5% of MVC and 35% reduction in lengthening fluctuations at both 30% and 65% of MVC. FRT induced a 60% reduction in shortening fluctuations at 30% of MVC. No adaptations in dynamic steadiness were observed in the FT group. Further analysis indicated that those who were the least steady at baseline showed the greatest training effects during isometric (RT: R super(2)=0.25, FRT: R super(2)=0.49, FT: R super(2)=0.38), shortening (RT: R super(2)=0.36, FRT: R super(2)=0.36, FT: R super(2)=0.35) and lengthening (RT: r super(2)=0.29, FRT: r super(2)=0.44) contractions. In conclusion, steadiness improvements in groups performing resistance exercise, without a concomitant improvement in the FT group, supports a role for task-specificity in explaining steadiness adaptations, particularly for unsteady older adults. JF - European Journal of Applied Physiology AU - Manini, T M AU - Clark, B C AU - Tracy, B L AU - Burke, J AU - Ploutz-Snyder, L AD - Musculoskeletal Research Laboratory, Syracuse University, Syracuse, NY, USA, maninit@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 436 EP - 446 PB - Springer-Verlag (New York), P.O. Box 2485 Secaucus NJ 07096-2485 USA, [mailto:orders@springer-ny.com], [URL:http://www.springer-ny.com/] VL - 95 IS - 5-6 SN - 1439-6319, 1439-6319 KW - Physical Education Index KW - Exercise physiology KW - Men KW - Analysis KW - Women KW - Gerontology KW - Knees KW - Isometrics KW - Adults KW - Resistance exercise KW - Movement KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17469256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Applied+Physiology&rft.atitle=Resistance+and+functional+training+reduces+knee+extensor+position+fluctuations+in+functionally+limited+older+adults&rft.au=Manini%2C+T+M%3BClark%2C+B+C%3BTracy%2C+B+L%3BBurke%2C+J%3BPloutz-Snyder%2C+L&rft.aulast=Manini&rft.aufirst=T&rft.date=2005-12-01&rft.volume=95&rft.issue=5-6&rft.spage=436&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Applied+Physiology&rft.issn=14396319&rft_id=info:doi/10.1007%2Fs00421-005-0048-x LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Exercise physiology; Men; Analysis; Women; Knees; Gerontology; Isometrics; Resistance exercise; Adults; Movement DO - http://dx.doi.org/10.1007/s00421-005-0048-x ER - TY - JOUR T1 - ORIGINAL ARTICLE: Selective inhibition by rottlerin of macropinocytosis in monocyte-derived dendritic cells AN - 17447082; 6550918 AB - We present here the analysis of fluid-phase endocytosis (FPE) in human blood monocytes and monocyte-derived dendritic cells (MDDC) facilitated by our serendipitous identification of rottlerin as an efficient inhibitor of dendritic cell FPE (IC sub(50) of 0.4 mu M). Rottlerin was found to be an excellent tool for FPE analysis: rapid-acting, irreversible and selective for FPE (as opposed to receptor-mediated endocytosis) at concentrations of 3 mu M and below. The inhibitory effect was not due to toxicity or visible change in membrane ruffles, but affects on cytoskeletal reorganization were evident in MDDC treated with relevant rottlerin concentrations during adhesion. A marked increase in FPE was observed in 1 hr interleukin (IL)-4 and granulocyte macrophage-colony stimulating factor (GM-CSF)-stimulated monocytes. Moreover, rottlerin inhibited the augmented FPE of 1-day cytokine treated monocytes and their augmented ability to induce T cell proliferative responses to tetanus toxoid. We conclude that rottlerin is a useful tool for investigating FPE and its functional importance. JF - Immunology AU - Sarkar, Kakali AU - Kruhlak, Michael J AU - Erlandsen, Stanley L AU - Shaw, Stephen AD - Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, sshaw@nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 513 EP - 524 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 116 IS - 4 SN - 0019-2805, 0019-2805 KW - rottlerin KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Interleukins KW - Granulocyte-macrophage colony-stimulating factor KW - Toxoids KW - Toxicity KW - Tetanus KW - Cytoskeleton KW - Blood KW - Endocytosis KW - Dendritic cells KW - Pinocytosis KW - Lymphocytes T KW - Vaccines KW - Monocytes KW - J 02350:Immunology KW - F 06622:Dendritic cells (plasmacytoid, monocyte-derived, Langerhans) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17447082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunology&rft.atitle=ORIGINAL+ARTICLE%3A+Selective+inhibition+by+rottlerin+of+macropinocytosis+in+monocyte-derived+dendritic+cells&rft.au=Sarkar%2C+Kakali%3BKruhlak%2C+Michael+J%3BErlandsen%2C+Stanley+L%3BShaw%2C+Stephen&rft.aulast=Sarkar&rft.aufirst=Kakali&rft.date=2005-12-01&rft.volume=116&rft.issue=4&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=Immunology&rft.issn=00192805&rft_id=info:doi/10.1111%2Fj.1365-2567.2005.02253.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - SuppNotes - Figures, 10; references, 46. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Granulocyte-macrophage colony-stimulating factor; Interleukins; Toxicity; Toxoids; Tetanus; Cytoskeleton; Dendritic cells; Endocytosis; Blood; Pinocytosis; Lymphocytes T; Monocytes; Vaccines DO - http://dx.doi.org/10.1111/j.1365-2567.2005.02253.x ER - TY - JOUR T1 - Bacterial metal detectors AN - 17438677; 6555897 AB - Gram negative bacteria can detect environmental iron using outer membrane transporters (OMTs), and then regulate certain transport genes to take advantage of a readily available iron source. This process begins with an iron complex being bound by an OMT, and results in a signal being sent across the outer membrane, the periplasmic space, and the inner membrane, to a sigma factor that interacts with RNA polymerase and initiates transcription of relevant genes. Many of the interactions contributing to signalling have been observed by genetic and biochemical studies, but structural studies, which potentially show these interactions in molecular detail, have been limited. In this issue, Garcia-Herrero and Vogel describe an NMR structure of the periplasmic domain of an OMT, which had not been seen in previous X-ray crystal structures. This domain transmits the 'iron availability' signal to the next protein in the signal transduction cascade, which sits in the inner membrane and extends into the periplasm. The new structure extends our knowledge of transporter architecture and suggests how signalling may occur across the outer membrane. JF - Molecular Microbiology AU - Buchanan, Susan K AD - Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA, skbuchan@helix.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1205 EP - 1209 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 58 IS - 5 SN - 0950-382X, 0950-382X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Bacteria KW - Metals KW - Periplasmic space KW - Heavy metals KW - Outer membranes KW - Transcription KW - DNA-directed RNA polymerase KW - Ionizing radiation KW - Gram-negative bacteria KW - Inner membranes KW - Crystal structure KW - N.M.R. KW - Sigma factor KW - Iron KW - periplasm KW - Signal transduction KW - J 02721:Cell cycle, morphology and motility KW - A 01450:Environmental Pollution & Waste Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17438677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Bacterial+metal+detectors&rft.au=Buchanan%2C+Susan+K&rft.aulast=Buchanan&rft.aufirst=Susan&rft.date=2005-12-01&rft.volume=58&rft.issue=5&rft.spage=1205&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2005.04904.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - SuppNotes - Figures, 3; references, 14. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Metals; Heavy metals; Periplasmic space; Outer membranes; Transcription; DNA-directed RNA polymerase; Inner membranes; Gram-negative bacteria; Ionizing radiation; Crystal structure; N.M.R.; Sigma factor; periplasm; Iron; Signal transduction; Bacteria DO - http://dx.doi.org/10.1111/j.1365-2958.2005.04904.x ER - TY - JOUR T1 - Differential cis-regulation of human versus mouse TERT gene expression in vivo: Identification of a human-specific repressive element AN - 17438513; 6578684 AB - In vivo expression of human telomerase is significantly different from that of mouse telomerase. To assess the basis for this difference, a bacterial artificial chromosome clone containing the entire hTERT (human telomerase reverse transcriptase) gene was introduced in mice. In these transgenic mice, expression of the hTERT transgene was similar to that of endogenous hTERT in humans, rather than endogenous mTERT (mouse telomerase reverse transcriptase). In tissues and cells showing a striking difference in expression levels between hTERT in humans and mTERT in mice (i.e., liver, kidney, lung, uterus, and fibroblasts), expression of the hTERT transgene in transgenic mice was repressed, mimicking hTERT in humans. The transcriptional activity of the hTERT promoter was much lower than that of the mTERT promoter in mouse embryonic fibroblasts or human fibroblasts. Mutational analysis of the hTERT and mTERT promoters revealed that a nonconserved GC-box within the hTERT promoter was responsible for the human-specific repression. These results reveal that a difference in cis-regulation of transcription, rather than transacting transcription factors, is critical to species differences in tissue-specific TERT expression. Our data also suggest that the GC-box-mediated, human-specific mechanism for TERT repression is impaired in human cancers. This study represents a detailed characterization of the functional difference in a gene promoter of mice versus humans and provides not only important insight into species-specific regulation of telomerase and telomeres but also an experimental basis for generating mice humanized for telomerase enzyme and its pattern of expression. JF - Proceedings of the National Academy of Sciences, USA AU - Horikawa, Izumi AU - Chiang, YJeffrey AU - Patterson, Tricia AU - Feigenbaum, Lionel AU - Leem, Sun-Hee AU - Michishita, Eriko AU - Larionov, Vladimir AU - Hodes, Richard J AU - Barrett, JCarl AD - Laboratory of Biosystems and Cancer and Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 18437 EP - 18442 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 102 IS - 51 SN - 0027-8424, 0027-8424 KW - mice KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Oncogenes & Growth Factors Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Mimicry KW - Uterus KW - Data processing KW - Transgenes KW - Enzymes KW - telomerase reverse transcriptase KW - Transgenic mice KW - Cancer KW - Fibroblasts KW - Gene expression KW - Bacterial artificial chromosomes KW - Telomeres KW - Promoters KW - Lung KW - Transcription factors KW - Embryo fibroblasts KW - Liver KW - Kidney KW - Embryos KW - Telomerase reverse transcriptase KW - J 02310:Genetics & Taxonomy KW - B 26248:DNA repair KW - N 14045:Transcriptional regulation KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17438513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Differential+cis-regulation+of+human+versus+mouse+TERT+gene+expression+in+vivo%3A+Identification+of+a+human-specific+repressive+element&rft.au=Horikawa%2C+Izumi%3BChiang%2C+YJeffrey%3BPatterson%2C+Tricia%3BFeigenbaum%2C+Lionel%3BLeem%2C+Sun-Hee%3BMichishita%2C+Eriko%3BLarionov%2C+Vladimir%3BHodes%2C+Richard+J%3BBarrett%2C+JCarl&rft.aulast=Horikawa&rft.aufirst=Izumi&rft.date=2005-12-01&rft.volume=102&rft.issue=51&rft.spage=18437&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Mimicry; Uterus; Data processing; Transgenes; Enzymes; telomerase reverse transcriptase; Transgenic mice; Cancer; Fibroblasts; Bacterial artificial chromosomes; Gene expression; Promoters; Telomeres; Lung; Transcription factors; Embryo fibroblasts; Kidney; Liver; Embryos; Telomerase reverse transcriptase ER - TY - JOUR T1 - Cocaine-induced CREB phosphorylation in nucleus accumbens of cocaine-sensitized rats is enabled by enhanced activation of extracellular signal-related kinase, but not protein kinase A AN - 17435276; 6552992 AB - Repeated cocaine administration to rats outside their home cages sensitizes the behavioral effects of the drug, and enhances induction of the immediate early gene product Fos in nucleus accumbens. We hypothesized that the same treatment regimen would also enhance cocaine-induced activation of intracellular signaling kinases that phosphorylate cyclic AMP-regulated element-binding protein (CREB), an important mediator of c-fos transcription. Phosphorylation levels of extracellular signal-regulated kinase (ERK)-mitogen-activated protein kinase (MAPK), calcium-calmodulin kinases (CaMKs) II and IV, and CREB were used to assess endogenous functional activity of these signaling molecules in rats behaviorally sensitized outside their home cages. Protein kinase A (PKA)-specific phosphorylation of Ser845 in the alpha -amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor subunit GluR1 was used to assess endogenous functional activity of PKA. Using western blots and immunohistochemistry, we detected cocaine-induced CREB phosphorylation after repeated cocaine administration, but not after repeated saline administration. Using western blots and MAPK activity assays, we found that cocaine-induced phosphorylation and activation of ERK, but not of CaMKs II or IV or GluR1, was augmented in nucleus accumbens of cocaine-sensitized rats. Unilateral infusions of the MAPK kinase inhibitor U0126 into nucleus accumbens attenuated cocaine-induced ERK and CREB phosphorylation in cocaine-sensitized rats. In contrast, unilateral infusions of the PKA inhibitor Rp-isomer of adenosine-3',5'-cyclicmonophosphorothioate (Rp-cAMPs) did not affect cocaine-induced CREB phosphorylation. Therefore, enhanced activation of ERK, but not PKA, enables and mediates cocaine-induced CREB phosphorylation in nucleus accumbens of rats that are sensitized by repeated cocaine administration outside their home cages. JF - Journal of Neurochemistry AU - Mattson, Brandi J AU - Bossert, Jennifer M AU - Simmons, Danielle E AU - Nozaki, Naohito AU - Nagarkar, Deepti AU - Kreuter, Justin D AU - Hope, Bruce T AD - Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA, bhope@intra.nida.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1481 EP - 1494 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 95 IS - 5 SN - 0022-3042, 0022-3042 KW - rats KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Intracellular signalling KW - Western blotting KW - Nucleus accumbens KW - MAP kinase KW - Protein kinase A KW - Transcription KW - c-Fos protein KW - Drug abuse KW - alpha -Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors KW - Glutamic acid receptors (ionotropic) KW - Fos protein KW - Extracellular signal-regulated kinase KW - Phosphorylation KW - alpha -Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid KW - Cocaine KW - Ca super(2+)/calmodulin-dependent protein kinase II KW - Immunohistochemistry KW - Cyclic AMP response element-binding protein KW - Signal transduction KW - N3 11106:Neurobiology of drug abuse KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17435276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurochemistry&rft.atitle=Cocaine-induced+CREB+phosphorylation+in+nucleus+accumbens+of+cocaine-sensitized+rats+is+enabled+by+enhanced+activation+of+extracellular+signal-related+kinase%2C+but+not+protein+kinase+A&rft.au=Mattson%2C+Brandi+J%3BBossert%2C+Jennifer+M%3BSimmons%2C+Danielle+E%3BNozaki%2C+Naohito%3BNagarkar%2C+Deepti%3BKreuter%2C+Justin+D%3BHope%2C+Bruce+T&rft.aulast=Mattson&rft.aufirst=Brandi&rft.date=2005-12-01&rft.volume=95&rft.issue=5&rft.spage=1481&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurochemistry&rft.issn=00223042&rft_id=info:doi/10.1111%2Fj.1471-4159.2005.03500.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - SuppNotes - Figures, 9; references, 65. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Nucleus accumbens; Western blotting; Intracellular signalling; Protein kinase A; MAP kinase; Transcription; c-Fos protein; Drug abuse; alpha -Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors; Glutamic acid receptors (ionotropic); Fos protein; Extracellular signal-regulated kinase; Phosphorylation; alpha -Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; Cocaine; Immunohistochemistry; Ca super(2+)/calmodulin-dependent protein kinase II; Signal transduction; Cyclic AMP response element-binding protein DO - http://dx.doi.org/10.1111/j.1471-4159.2005.03500.x ER - TY - JOUR T1 - Crystal structures of T cell receptor beta chains related to rheumatoid arthritis AN - 17429726; 6581427 AB - The crystal structures of the V beta 17 super(+) beta chains of two human T cell receptors (TCRs), originally derived from the synovial fluid (SF4) and tissue (C5-1) of a patient with rheumatoid arthritis (RA), have been determined in native (SF4) and mutant (C5-1 sub(F104 arrow right Y/C187 arrow right S)) forms, respectively. These TCR beta chains form homo-dimers in solution and in crystals. Structural comparison reveals that the main-chain conformations in the CDR regions of the C5-1 and SF4 V beta 17 closely resemble those of a V beta 17 JM22 in a bound form; however, the CDR3 region shows different conformations among these three V beta 17 structures. At the side-chain level, conformational differences were observed at the CDR2 regions between our two ligand-free forms and the bound JM22 form. Other significant differences were observed at the V beta regions 8-12, 40-44, and 82-88 between C5-1/SF4 and JM22 V beta 17, implying that there is considerable variability in the structures of very similar beta chains. Structural alignments also reveal a considerable variation in the V beta -C beta associations, and this may affect ligand recognition. The crystal structures also provide insights into the structure basis of T cell recognition of Mycoplasma arthritidis mitogen (MAM), a superantigen that may be implicated in the development of human RA. Structural comparisons of the V beta domains of known TCR structures indicate that there are significant similarities among V beta regions that are MAM-reactive, whereas there appear to be significant structural differences among those V beta regions that lack MAM-reactivity. It further reveals that CDR2 and framework region (FR) 3 are likely to account for the binding of TCR to MAM. JF - Protein Science AU - Li, Hongmin AU - Van Vranken, Sandra AU - Zhao, Yiwei AU - Li, Zhong AU - Guo, Yi AU - Eisele, Leslie AU - Li, Yixin AD - Wadsworth Center, New York State Department of Health, and Department of Biomedical Sciences, School of Public Health, University at Albany, State University of New York, Empire State Plaza, Albany, New York 12201-0509, USA. Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 3025 EP - 3038 PB - Cold Spring Harbor Laboratory Press, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 14 IS - 12 SN - 0961-8368, 0961-8368 KW - Microbiology Abstracts B: Bacteriology KW - complementarity-determining region 3 KW - Rheumatoid arthritis KW - Superantigens KW - Synovial fluid KW - double prime T-cell receptor KW - Mycoplasma arthritidis KW - Crystal structure KW - Lymphocytes T KW - Proteins KW - Mitogens KW - Crystals KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17429726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Science&rft.atitle=Crystal+structures+of+T+cell+receptor+beta+chains+related+to+rheumatoid+arthritis&rft.au=Li%2C+Hongmin%3BVan+Vranken%2C+Sandra%3BZhao%2C+Yiwei%3BLi%2C+Zhong%3BGuo%2C+Yi%3BEisele%2C+Leslie%3BLi%2C+Yixin&rft.aulast=Li&rft.aufirst=Hongmin&rft.date=2005-12-01&rft.volume=14&rft.issue=12&rft.spage=3025&rft.isbn=&rft.btitle=&rft.title=Protein+Science&rft.issn=09618368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - complementarity-determining region 3; Superantigens; Rheumatoid arthritis; Synovial fluid; double prime T-cell receptor; Lymphocytes T; Crystal structure; Mitogens; Proteins; Crystals; Mycoplasma arthritidis ER - TY - JOUR T1 - TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis AN - 17428442; 6577859 AB - To investigate the role of Toll-like receptor (TLR)9 in the immune response to mycobacteria as well as its cooperation with TLR2, a receptor known to be triggered by several major mycobacterial ligands, we analyzed the resistance of TLR9 super(-/-) as well as TLR2/9 double knockout mice to aerosol infection with Mycobacterium tuberculosis. Infected TLR9 super(-/-) but not TLR2 super(-/-) mice displayed defective mycobacteria-induced interleukin (IL)-12p40 and interferon (IFN)- gamma responses in vivo, but in common with TLR2 super(-/-) animals, the TLR9 super(-/-) mice exhibited only minor reductions in acute resistance to low dose pathogen challenge. When compared with either of the single TLR-deficient animals, TLR2/9 super(-/-) mice displayed markedly enhanced susceptibility to infection in association with combined defects in proinflammatory cytokine production in vitro, IFN- gamma recall responses ex vivo, and altered pulmonary pathology. Cooperation between TLR9 and TLR2 was also evident at the level of the in vitro response to live M. tuberculosis, where dendritic cells and macrophages from TLR2/9 super(-/-) mice exhibited a greater defect in IL-12 response than the equivalent cell populations from single TLR9-deficient animals. These findings reveal a previously unappreciated role for TLR9 in the host response to M. tuberculosis and illustrate TLR collaboration in host resistance to a major human pathogen. JF - Journal of Experimental Medicine AU - Bafica, Andre AU - Scanga, Charles A AU - Feng, Carl G AU - Leifer, Cynthia AU - Cheever, Allen AU - Sher, Alan AD - Immunobiology Section, Laboratory of Parasitic Diseases. Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. Laboratorio de Imunorregulacao e Microbiologia, Centro de Pesquisas Goncalo Moniz, FIOCRUZ, Bahia 40296-710, Brazil. Biomedical Research Institute, Rockville, MD 20852 Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1715 EP - 1724 PB - Rockefeller University Press, 1114 First Avenue New York NY 10021-8325 USA, [mailto:Bruce.Lyons@rockefeller.edu], [URL:http://www.rockefeller.edu/rupress] VL - 202 IS - 12 SN - 0022-1007, 0022-1007 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - gamma -Interferon KW - Aerosols KW - TLR9 protein KW - TLR2 protein KW - Pathogens KW - Infection KW - Inflammation KW - Interleukin 12 KW - Dendritic cells KW - Tuberculosis KW - Toll-like receptors KW - Mycobacterium tuberculosis KW - J 02833:Immune response and immune mechanisms KW - F 06106:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17428442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Medicine&rft.atitle=TLR9+regulates+Th1+responses+and+cooperates+with+TLR2+in+mediating+optimal+resistance+to+Mycobacterium+tuberculosis&rft.au=Bafica%2C+Andre%3BScanga%2C+Charles+A%3BFeng%2C+Carl+G%3BLeifer%2C+Cynthia%3BCheever%2C+Allen%3BSher%2C+Alan&rft.aulast=Bafica&rft.aufirst=Andre&rft.date=2005-12-01&rft.volume=202&rft.issue=12&rft.spage=1715&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Medicine&rft.issn=00221007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Dendritic cells; Interleukin 12; gamma -Interferon; Aerosols; TLR9 protein; TLR2 protein; Tuberculosis; Pathogens; Infection; Toll-like receptors; Inflammation; Mycobacterium tuberculosis ER - TY - JOUR T1 - The Genome of Bacteriophage K1F, a T7-Like Phage That Has Acquired the Ability To Replicate on K1 Strains of Escherichia coli AN - 17424341; 6577046 AB - Bacteriophage K1F specifically infects Escherichia coli strains that produce the K1 polysaccharide capsule. Like several other K1 capsule-specific phages, K1F encodes an endo-neuraminidase (endosialidase) that is part of the tail structure which allows the phage to recognize and degrade the polysaccharide capsule. The complete nucleotide sequence of the K1F genome reveals that it is closely related to bacteriophage T7 in both genome organization and sequence similarity. The most striking difference between the two phages is that K1F encodes the endosialidase in the analogous position to the T7 tail fiber gene. This is in contrast with bacteriophage K1-5, another K1-specific phage, which encodes a very similar endosialidase which is part of a tail gene "module" at the end of the phage genome. It appears that diverse phages have acquired endosialidase genes by horizontal gene transfer and that these genes or gene products have adapted to different genome and virion architectures. JF - Journal of Bacteriology AU - Scholl, Dean AU - Merril, Carl AD - National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 8499 EP - 8503 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 187 IS - 24 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Virology & AIDS Abstracts KW - phage K1F KW - Phages KW - Virions KW - Endo- alpha -sialidase KW - Genomes KW - Tails KW - Nucleotide sequence KW - Polysaccharides KW - Genetic relationship KW - Gene transfer KW - Escherichia coli KW - Tail fibers KW - Genetic structure KW - G 07312:Phages KW - J 02750:Phage-host interactions KW - V 22070:Phage-host interactions including lysogeny & transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17424341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=The+Genome+of+Bacteriophage+K1F%2C+a+T7-Like+Phage+That+Has+Acquired+the+Ability+To+Replicate+on+K1+Strains+of+Escherichia+coli&rft.au=Scholl%2C+Dean%3BMerril%2C+Carl&rft.aulast=Scholl&rft.aufirst=Dean&rft.date=2005-12-01&rft.volume=187&rft.issue=24&rft.spage=8499&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Endo- alpha -sialidase; Virions; Genetic relationship; Phages; Tails; Gene transfer; Nucleotide sequence; Tail fibers; Polysaccharides; Genetic structure; phage K1F; Escherichia coli ER - TY - JOUR T1 - A detailed behavioral analysis of the acute motor effects of caffeine in the rat: involvement of adenosine A sub(1) and A sub(2A) receptors AN - 17205255; 6889206 AB - Rationale: There is no consensus on the contribution of adenosine A sub(1) and A sub(2A) receptor blockade to motor-activating effects of caffeine. Objective: Our aim was to use a detailed and continuous observational method to compare the motor effects induced by caffeine with those induced by selective A sub(1) and A sub(2A) receptor antagonists. Methods: The behavioral repertoire induced by systemic administration of caffeine (3, 10, and 30 mg/kg), A sub(1) receptor antagonist 8-cyclopentyl-1,3-dimethylxanthine (CPT; 1.2, 4.8 and 7.2 mg/kg), and A sub(2A) receptor antagonist 3-(3-hydroxypropyl)-8-(m-methoxystyryl)-7-methyl-1-propargylxan thine phosphate disodium salt (MSX-3; 1, 3, and 10 mg/kg) was analyzed. The effects of pretreatment with the selective A sub(1) receptor agonist N super(6)-cyclopentyladenosine (CPA; 0.1 mg/g) and the selective A sub(2A) receptor agonist 2-p-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxyamidoad enosine (CGS 21680; 0.2 mg/kg) on the pattern of motor activation induced by caffeine, CPT, or MSX-3 were also examined. Results: The pattern of behavioral activation induced by caffeine was better mimicked by CPT than by MSX-3. Coadministration of CPT and MSX-3 gave different results depending on the dose and the type of behavioral response. CPA was more effective at decreasing the activating effects of caffeine and CPT than those of CGS 21680. On the other hand, CGS 21680 was more effective at decreasing the activating effects of MSX-3 than those of caffeine or CPT. Factor analysis revealed a complex three-dimensional behavioral profile for caffeine that was similar to the profile for CPT and was different from the profile for MSX-3. Conclusions: The results indicate a predominant role for A sub(1) receptors in the motor-activating effects of acutely administered caffeine. JF - Psychopharmacology AU - Antoniou, Katerina AU - Papadopoulou-Daifoti, Zeta AU - Hyphantis, Thomas AU - Papathanasiou, Georgia AU - Bekris, Efstathios AU - Marselos, Marios AU - Panlilio, Leigh AU - Mueller, Christa E AU - Goldberg, Steven R AU - Ferre, Sergi AD - Behavioral Neuroscience Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD, 21224, USA, sferre@intra.nida.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 154 EP - 162 PB - Springer-Verlag (Berlin), Heidelberger Platz 3 Berlin 14197 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 183 IS - 2 SN - 0033-3158, 0033-3158 KW - Factor analysis KW - rats KW - CSA Neurosciences Abstracts; Animal Behavior Abstracts; Toxicology Abstracts KW - Motor activity KW - Caffeine KW - Adenosine A1 receptors KW - Adenosine A2A receptors KW - Y 25777:Mammals (excluding primates) KW - X 24180:Social poisons & drug abuse KW - N3 11139:Toxicological and psychoactive drug correlates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17205255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=A+detailed+behavioral+analysis+of+the+acute+motor+effects+of+caffeine+in+the+rat%3A+involvement+of+adenosine+A+sub%281%29+and+A+sub%282A%29+receptors&rft.au=Antoniou%2C+Katerina%3BPapadopoulou-Daifoti%2C+Zeta%3BHyphantis%2C+Thomas%3BPapathanasiou%2C+Georgia%3BBekris%2C+Efstathios%3BMarselos%2C+Marios%3BPanlilio%2C+Leigh%3BMueller%2C+Christa+E%3BGoldberg%2C+Steven+R%3BFerre%2C+Sergi&rft.aulast=Antoniou&rft.aufirst=Katerina&rft.date=2005-12-01&rft.volume=183&rft.issue=2&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/10.1007%2Fs00213-005-0173-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Motor activity; Adenosine A1 receptors; Caffeine; Adenosine A2A receptors DO - http://dx.doi.org/10.1007/s00213-005-0173-6 ER - TY - JOUR T1 - Characterization of Both MTBE and BTEX in the Ambient Air of Night Markets in Southern Taiwan AN - 17135377; 6756488 AB - To characterize concentrations of volatile organic compounds (VOCs) at the night markets in southern Taiwan, four representative night markets and one background location were selected for this study. The VOCs measured included methyl tertiary-butyl ether (MTBE) and BTEX (the acronym for benzene, toluene, ethylbenzene, and xylene). The results indicated that the measured concentrations of MTBE and BTEX were typically on the order of one to two times higher at night market level than at the background site. It is clear that the night market activities in all sampling sites affected the distribution of MTBE and BTEX. During non-night market activities, the average MTBE-BTEX ratios of Liu-Ho, Rui-Guang, Ping-Tung and Chao-Zhou were (13.9: 2.2: 10.1: 1.0: 6.1), (4.9: 3.8: 13.7: 1.0: 7.9), (10.3: 1.7: 8.2: 1.0: 3.9) and (87.4: 10: 46: 1.0: 9.1), respectively. However, during the night market activities, the average MTBE-BTEX ratios shifted to (27.4: 1.9: 21.9: 1.0: 4.3), (23.1: 3.9: 16.5: 1.0: 3.2), (38.6: 6.8: 30.1: 1.0: 14.9), and (38.6: 7.8: 24.3: 1.0: 5.1), respectively. JF - Aerosol and Air Quality Resarch AU - Hsieh, Lien-Te AU - Yang, His-Hsieh AU - Chen, Ho-Wen AD - Department of Environmental Engineering and Science, National Pingtung University of Science and Technology, Nei Pu 912, Ping Tung, Taiwan, Lthsieh@.mail.npust.edu.tw Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 154 EP - 170 VL - 5 IS - 2 SN - 1680-8584, 1680-8584 KW - Meteorological & Geoastrophysical Abstracts; Pollution Abstracts KW - Taiwan KW - Aerosols KW - Atmospheric pollution KW - MTBE KW - Toluene KW - Acronyms KW - Air quality KW - Benzene KW - Xylene KW - Chemical speciation KW - Volatile organic compounds KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17135377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aerosol+and+Air+Quality+Resarch&rft.atitle=Characterization+of+Both+MTBE+and+BTEX+in+the+Ambient+Air+of+Night+Markets+in+Southern+Taiwan&rft.au=Hsieh%2C+Lien-Te%3BYang%2C+His-Hsieh%3BChen%2C+Ho-Wen&rft.aulast=Hsieh&rft.aufirst=Lien-Te&rft.date=2005-12-01&rft.volume=5&rft.issue=2&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Aerosol+and+Air+Quality+Resarch&rft.issn=16808584&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Atmospheric pollution; Acronyms; Air quality; Aerosols; Xylene; Toluene; Chemical speciation; MTBE; Benzene; Volatile organic compounds; Taiwan ER - TY - JOUR T1 - Post insult enriched housing improves the 8-arm radial maze performance but not the Morris water maze task in ventral subicular lesioned rats. AN - 68881836; 16324686 AB - The present study attempted to evaluate the efficacy of enriched housing conditions in promoting behavioral recovery following subicular lesion. Rats with bilateral ibotenic acid lesions of ventral subiculum were exposed to either enriched housing conditions or standard housing for 6 h daily for 10 days. The performance of the lesioned rats reared in standard housing conditions was severely impaired in both 8-arm radial maze and water maze tasks. Lesioned rats exposed to enriched housing showed behavioral recovery in the 8-arm radial maze but not in the water maze. Our study suggests the possibility that recovery may be based on the functional demand of spatial tasks and may require more appropriate environmental stimulation. JF - Brain research AU - Bindu, B AU - Rekha, J AU - Kutty, Bindu M AD - Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences (NIMHANS), P.O. Box No.2900, Hosur Road, Bangalore-560 029, India. Y1 - 2005/11/30/ PY - 2005 DA - 2005 Nov 30 SP - 121 EP - 131 VL - 1063 IS - 2 SN - 0006-8993, 0006-8993 KW - Excitatory Amino Acid Agonists KW - 0 KW - Ibotenic Acid KW - 2552-55-8 KW - Index Medicus KW - Rats KW - Animals KW - Housing, Animal KW - Rats, Wistar KW - Recovery of Function -- physiology KW - Ibotenic Acid -- toxicity KW - Excitatory Amino Acid Agonists -- toxicity KW - Male KW - Environment Design KW - Maze Learning -- physiology KW - Nerve Degeneration -- physiopathology KW - Nerve Degeneration -- pathology KW - Nerve Degeneration -- chemically induced KW - Hippocampus -- physiopathology KW - Behavior, Animal -- physiology KW - Hippocampus -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68881836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Post+insult+enriched+housing+improves+the+8-arm+radial+maze+performance+but+not+the+Morris+water+maze+task+in+ventral+subicular+lesioned+rats.&rft.au=Bindu%2C+B%3BRekha%2C+J%3BKutty%2C+Bindu+M&rft.aulast=Bindu&rft.aufirst=B&rft.date=2005-11-30&rft.volume=1063&rft.issue=2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-15 N1 - Date created - 2005-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A quantitative slot blot assay for host cell protein impurities in recombinant proteins expressed in E. coli AN - 17451757; 6637944 AB - Residual host cell protein impurities in recombinant proteins intended for human use must be accurately quantified to help establish their safety. We describe a novel means of host cell protein quantitation, in which a slot blot system was employed together with scanning laser densitometry to allow picogram level sensitivity in detection of residual host cell proteins in unpurified fermentation products and final purified bulk samples. Two allelic forms of merozoite surface protein 1, a promising malaria vaccine candidate antigen currently undergoing evaluation in clinical trials, were expressed in E. coli as clinical grade proteins, refolded, and carried through several chromatographic purification steps. Several lots of these proteins were analyzed with this generic quantitative assay that uses rat polyclonal antibodies generated against soluble and insoluble E. coli proteins. The assay had a detection range of 6.1-1562 ng/mL, with a detection limit of 6.1 ng/mL, comparable to reported ELISA-based methods. This assay proved simple yet very sensitive and accurate, giving highly reproducible results. Thus it is suitable for evaluating host cell protein levels in clinical grade recombinant proteins expressed in E. coli. electrophoresis JF - Journal of Immunological Methods AU - Zhu, D AU - Saul, A J AU - Miles, A P AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA, dzhu@niaid.nih.gov Y1 - 2005/11/30/ PY - 2005 DA - 2005 Nov 30 SP - 40 EP - 50 PB - Elsevier B.V. VL - 306 IS - 1-2 SN - 0022-1759, 0022-1759 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Immunology Abstracts KW - Enzyme-linked immunosorbent assay KW - Electrophoresis KW - Fermentation KW - Impurities KW - Merozoite surface protein 1 KW - Malaria KW - protein purification KW - Clinical trials KW - Antibodies KW - Escherichia coli KW - Vaccines KW - Quantitation KW - Densitometry KW - K 03410:Animal Diseases KW - W 30965:Miscellaneous, Reviews KW - W3 33250:Methods: Others KW - F 06708:Other methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17451757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=A+quantitative+slot+blot+assay+for+host+cell+protein+impurities+in+recombinant+proteins+expressed+in+E.+coli&rft.au=Zhu%2C+D%3BSaul%2C+A+J%3BMiles%2C+A+P&rft.aulast=Zhu&rft.aufirst=D&rft.date=2005-11-30&rft.volume=306&rft.issue=1-2&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2005.07.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Antibodies; Electrophoresis; Fermentation; Impurities; Malaria; Merozoite surface protein 1; Vaccines; protein purification; Quantitation; Clinical trials; Densitometry; Escherichia coli DO - http://dx.doi.org/10.1016/j.jim.2005.07.021 ER - TY - JOUR T1 - Knockout of caspase-like gene, YCA1, abrogates apoptosis and elevates oxidized proteins in Saccharomyces cerevisiae. AN - 68845691; 16301538 AB - In our previous study, we established that inhibition of apoptosis by the general caspase inhibitor is associated with an increase in the level of oxidized proteins in a multicellular eukaryotic system. To gain further insight into a potential link between oxidative stress and apoptosis, we carried out studies with Saccharomyces cerevisiae, which contains a gene (YCA1) that encodes synthesis of metacaspase, a homologue of the mammalian caspase, and is known to play a crucial role in the regulation of yeast apoptosis. We show that upon exposure to H(2)O(2), the accumulation of protein carbonyls is much greater in a Delta yca1 strain lacking the YCA1 gene than in the wild type and that apoptosis was abrogated in the Delta yca1 strain, whereas wild type underwent apoptosis as measured by externalization of phosphatidylserine and the display of TUNEL-positive nuclei. We also show that H(2)O(2)-mediated stress leads to up-regulation of the 20S proteasome and suppression of ubiquitinylation activities. These findings suggest that deletion of the apoptotic-related caspase-like gene leads to a large H(2)O(2)-dependent accumulation of oxidized proteins and up-regulation of 20S proteasome activity. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Khan, Mohammed A S AU - Chock, P Boon AU - Stadtman, Earl R AD - Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-8012, USA. Y1 - 2005/11/29/ PY - 2005 DA - 2005 Nov 29 SP - 17326 EP - 17331 VL - 102 IS - 48 SN - 0027-8424, 0027-8424 KW - Phosphatidylserines KW - 0 KW - Saccharomyces cerevisiae Proteins KW - Hydrogen Peroxide KW - BBX060AN9V KW - Caspases KW - EC 3.4.22.- KW - MCA1 protein, S cerevisiae KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Index Medicus KW - Protein Carbonylation -- drug effects KW - Hydrogen Peroxide -- toxicity KW - In Situ Nick-End Labeling KW - Immunoblotting KW - Phosphatidylserines -- metabolism KW - Up-Regulation -- drug effects KW - Proteasome Endopeptidase Complex -- drug effects KW - Flow Cytometry KW - Saccharomyces cerevisiae -- genetics KW - Apoptosis -- genetics KW - Saccharomyces cerevisiae -- physiology KW - Saccharomyces cerevisiae Proteins -- genetics KW - Oxidative Stress -- genetics KW - Caspases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68845691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Knockout+of+caspase-like+gene%2C+YCA1%2C+abrogates+apoptosis+and+elevates+oxidized+proteins+in+Saccharomyces+cerevisiae.&rft.au=Khan%2C+Mohammed+A+S%3BChock%2C+P+Boon%3BStadtman%2C+Earl+R&rft.aulast=Khan&rft.aufirst=Mohammed+A&rft.date=2005-11-29&rft.volume=102&rft.issue=48&rft.spage=17326&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-22 N1 - Date created - 2005-11-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2000 Mar 10;275(10):7337-42 [10702305] Curr Genet. 2002 Jul;41(4):208-16 [12172961] Annu Rev Neurosci. 2000;23:73-87 [10845059] Biochimie. 2001 Mar-Apr;83(3-4):301-10 [11295490] Mol Biol Cell. 2001 Aug;12(8):2422-32 [11514626] Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):12920-5 [11606777] Electrophoresis. 2004 May;25(9):1334-41 [15174056] Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11560-5 [15284441] FEMS Yeast Res. 2004 Nov;5(2):111-7 [15489193] FEMS Yeast Res. 2004 Nov;5(2):141-7 [15489197] J Biol Chem. 1985 Oct 15;260(23):12600-6 [2864341] Curr Top Cell Regul. 1986;28:291-337 [2878793] J Biol Chem. 1987 Jun 15;262(17):8227-34 [3597373] J Biol Chem. 1987 Jul 15;262(20):9895-901 [3036875] Annu Rev Biochem. 1993;62:797-821 [8352601] FEBS Lett. 2002 Sep 25;528(1-3):23-6 [12297273] Free Radic Biol Med. 2002 Nov 1;33(9):1209-20 [12398929] Science. 2003 Mar 14;299(5613):1751-3 [12610228] Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14327-32 [14623979] J Cell Biol. 2004 Feb 16;164(4):501-7 [14970189] Chem Res Toxicol. 1993 Jul-Aug;6(4):430-3 [8374038] Methods Enzymol. 1994;233:346-57 [8015469] Yeast. 1994 Sep;10(9):1141-55 [7754704] Pharmacol Ther. 1996;72(1):37-50 [8981570] Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15036-40 [8986759] Microsc Res Tech. 1997 Jan 15;36(2):123-9 [9015258] Drug Metab Rev. 1998 May;30(2):225-43 [9606602] Biochem J. 1998 Nov 1;335 ( Pt 3):637-42 [9794805] Nature. 1998 Nov 12;396(6707):119-22 [9823889] Exp Cell Res. 1999 May 1;248(2):381-90 [10222130] J Cell Biol. 1999 May 17;145(4):757-67 [10330404] J Biol Chem. 2004 Dec 10;279(50):52623-9 [15381697] Biochim Biophys Acta. 2005 Jan 17;1703(2):261-6 [15680234] J Biol Chem. 2005 Apr 15;280(15):14691-9 [15691845] Mol Cell. 2002 Apr;9(4):911-7 [11983181] Hum Exp Toxicol. 2002 Feb;21(2):83 [12102501] Arch Biochem Biophys. 2002 Aug 15;404(2):279-84 [12147266] J Gerontol A Biol Sci Med Sci. 2000 May;55(5):B220-7 [10819308] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An inhibitor of TRPV1 channels isolated from funnel Web spider venom. AN - 68812062; 16300403 AB - Capsaicin receptor channels (TRPV1) are nonselective cation channels that integrate multiple noxious stimuli in sensory neurons. In an effort to identify new inhibitors of these channels we screened a venom library for activity against TRPV1 channels and found robust inhibitory activity in venom from Agelenopsis aperta, a north American funnel web spider. Fractionation of the venom using reversed-phase HPLC resulted in the purification of two acylpolyamine toxins, AG489 and AG505, which inhibit TRPV1 channels from the extracellular side of the membrane. The activity of AG489 was characterized further, and the toxin was found to inhibit TRPV1 channels with a K(i) of 0.3 microM at -40 mV. Inhibition of TRPV1 channels by AG489 is strongly voltage-dependent, with relief of inhibition at positive voltages, consistent with the toxin inhibiting the channel through a pore-blocking mechanism. We used scanning mutagenesis throughout the TM5-TM6 linker, a region thought to form the outer pore of TRPV1 channels, to identify pore mutations that alter toxin affinity. Four mutants dramatically decrease toxin affinity and several mutants increase toxin affinity, consistent with the notion that the TM5-TM6 linker forms the outer vestibule of TRPV1 channels and that AG489 is a pore blocker. JF - Biochemistry AU - Kitaguchi, Tetsuya AU - Swartz, Kenton J AD - Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2005/11/29/ PY - 2005 DA - 2005 Nov 29 SP - 15544 EP - 15549 VL - 44 IS - 47 SN - 0006-2960, 0006-2960 KW - Agatoxins KW - 0 KW - FTX, spider toxin KW - Polyamines KW - Spider Venoms KW - TRPV Cation Channels KW - Trpv1 protein, rat KW - agatoxin-489 KW - 128549-96-2 KW - Index Medicus KW - Animals KW - Models, Molecular KW - Chemical Fractionation KW - Spider Venoms -- chemistry KW - Electrophysiology KW - Mutagenesis KW - Rats KW - Transfection KW - Xenopus KW - Oocytes KW - Spider Venoms -- genetics KW - Spider Venoms -- pharmacology KW - Polyamines -- pharmacology KW - Polyamines -- chemistry KW - TRPV Cation Channels -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68812062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=An+inhibitor+of+TRPV1+channels+isolated+from+funnel+Web+spider+venom.&rft.au=Kitaguchi%2C+Tetsuya%3BSwartz%2C+Kenton+J&rft.aulast=Kitaguchi&rft.aufirst=Tetsuya&rft.date=2005-11-29&rft.volume=44&rft.issue=47&rft.spage=15544&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-03 N1 - Date created - 2005-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Modulation of Werner syndrome protein function by a single mutation in the conserved RecQ domain. AN - 68815968; 16150736 AB - Naturally occurring mutations in the human RECQ3 gene result in truncated Werner protein (WRN) and manifest as a rare premature aging disorder, Werner syndrome. Cellular and biochemical studies suggest a multifaceted role of WRN in DNA replication, DNA repair, recombination, and telomere maintenance. The RecQ C-terminal (RQC) domain of WRN was determined previously to be the major site of interaction for DNA and proteins. By using site-directed mutagenesis in the WRN RQC domain, we determined which amino acids might be playing a critical role in WRN function. A site-directed mutation at Lys-1016 significantly decreased WRN binding to fork or bubble DNA substrates. Moreover, the Lys-1016 mutation markedly reduced WRN helicase activity on fork, D-loop, and Holliday junction substrates in addition to reducing significantly the ability of WRN to stimulate FEN-1 incision activities. Thus, DNA binding mediated by the RQC domain is crucial for WRN helicase and its coordinated functions. Our nuclear magnetic resonance data on the three-dimensional structure of the wild-type RQC and Lys-1016 mutant proteins display a remarkable similarity in their structures. JF - The Journal of biological chemistry AU - Lee, Jae Wan AU - Kusumoto, Rika AU - Doherty, Kevin M AU - Lin, Guang-Xin AU - Zeng, Wangyong AU - Cheng, Wen-Hsing AU - von Kobbe, Cayetano AU - Brosh, Robert M AU - Hu, Jin-Shan AU - Bohr, Vilhelm A AD - Laboratory of Molecular Gerontology, NIA, National Institutes of Health, Baltimore, Maryland 21224-6825, USA. Y1 - 2005/11/25/ PY - 2005 DA - 2005 Nov 25 SP - 39627 EP - 39636 VL - 280 IS - 47 SN - 0021-9258, 0021-9258 KW - Recombinant Proteins KW - 0 KW - DNA KW - 9007-49-2 KW - Exodeoxyribonucleases KW - EC 3.1.- KW - Adenosine Triphosphatases KW - EC 3.6.1.- KW - RECQL protein, human KW - DNA Helicases KW - EC 3.6.4.- KW - RecQ Helicases KW - EC 3.6.4.12 KW - WRN protein, human KW - Werner Syndrome Helicase KW - Index Medicus KW - Humans KW - Mutagenesis, Site-Directed KW - Werner Syndrome -- etiology KW - Amino Acid Motifs KW - Recombinant Proteins -- metabolism KW - In Vitro Techniques KW - Molecular Sequence Data KW - Adenosine Triphosphatases -- chemistry KW - Recombinant Proteins -- chemistry KW - Sequence Homology, Amino Acid KW - Adenosine Triphosphatases -- genetics KW - Adenosine Triphosphatases -- metabolism KW - Amino Acid Sequence KW - Recombinant Proteins -- genetics KW - Mutation, Missense KW - Werner Syndrome -- metabolism KW - Base Sequence KW - Conserved Sequence KW - Nuclear Magnetic Resonance, Biomolecular KW - DNA -- genetics KW - Protein Structure, Tertiary KW - Werner Syndrome -- genetics KW - Cell Line KW - DNA Helicases -- chemistry KW - DNA Helicases -- metabolism KW - DNA Helicases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68815968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Modulation+of+Werner+syndrome+protein+function+by+a+single+mutation+in+the+conserved+RecQ+domain.&rft.au=Lee%2C+Jae+Wan%3BKusumoto%2C+Rika%3BDoherty%2C+Kevin+M%3BLin%2C+Guang-Xin%3BZeng%2C+Wangyong%3BCheng%2C+Wen-Hsing%3Bvon+Kobbe%2C+Cayetano%3BBrosh%2C+Robert+M%3BHu%2C+Jin-Shan%3BBohr%2C+Vilhelm+A&rft.aulast=Lee&rft.aufirst=Jae&rft.date=2005-11-25&rft.volume=280&rft.issue=47&rft.spage=39627&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-03 N1 - Date created - 2005-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The entomological inoculation rate and Plasmodium falciparum infection in African children AN - 17093271; 6718753 AB - Malaria is an important cause of global morbidity and mortality. The fact that some people are bitten more often than others has a large effect on the relationship between risk factors and prevalence of vector-borne diseases. Here we develop a mathematical framework that allows us to estimate the heterogeneity of infection rates from the relationship between rates of infectious bites and community prevalence. We apply this framework to a large, published data set that combines malaria measurements from more than 90 communities. We find strong evidence that heterogeneous biting or heterogeneous susceptibility to infection are important and pervasive factors determining the prevalence of infection: 20% of people receive 80% of all infections. We also find that individual infections last about six months on average, per infectious bite, and children who clear infections are not immune to new infections. The results have important implications for public health interventions: the success of malaria control will depend heavily on whether efforts are targeted at those who are most at risk of infection. JF - Nature AU - Smith, D L AU - Dushoff, J AU - Snow, R W AU - Hay, SI AD - Fogarty International Center, National Institutes of Health, Building 16, 16 Center Drive, Bethesda, Maryland 20892, USA, smitdave@helix.nih.gov Y1 - 2005/11/24/ PY - 2005 DA - 2005 Nov 24 SP - 492 EP - 495 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com] VL - 438 IS - 7067 SN - 0028-0836, 0028-0836 KW - African children KW - Mosquitoes KW - Entomology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 3: Aquatic Pollution & Environmental Quality KW - Biological vectors KW - Human diseases KW - Vector-borne diseases KW - Disease control KW - Culicidae KW - Malaria KW - Plasmodium falciparum KW - Infection KW - Risks KW - Public health KW - Disease transmission KW - Socioeconomic aspects KW - Biting KW - Africa KW - K 03090:Protozoa: human KW - Z 05206:Medical & veterinary entomology KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17093271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=The+entomological+inoculation+rate+and+Plasmodium+falciparum+infection+in+African+children&rft.au=Smith%2C+D+L%3BDushoff%2C+J%3BSnow%2C+R+W%3BHay%2C+SI&rft.aulast=Smith&rft.aufirst=D&rft.date=2005-11-24&rft.volume=438&rft.issue=7067&rft.spage=492&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/10.1038%2Fnature04024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Biological vectors; Human diseases; Socioeconomic aspects; Disease control; Malaria; Risks; Disease transmission; Public health; Biting; Vector-borne diseases; Infection; Culicidae; Plasmodium falciparum; Africa DO - http://dx.doi.org/10.1038/nature04024 ER - TY - JOUR T1 - Decreased levels of CXC-chemokines in serum of benzene-exposed workers identified by array-based proteomics. AN - 68821798; 16286641 AB - Benzene is an important industrial chemical and environmental contaminant that causes leukemia. To obtain mechanistic insight into benzene's mechanism of action, we examined the impact of benzene on the human serum proteome in a study of exposed healthy shoe-factory workers and unexposed controls. Two sequential studies were performed, each using sera from 10 workers exposed to benzene (overall mean benzene air level >30 ppm) and 10 controls. Serum samples were subjected to anion-exchange fractionation and bound to three types of ProteinChip arrays (Ciphergen Biosystems, Fremont, CA) [hydrophobic (H50), metal affinity (IMAC3-Cu), and cation exchange (WCX2)]. Protein-expression patterns were detected by surface-enhanced laser desorption/ionization (SELDI)-TOF MS. Three proteins (4.1, 7.7, and 9.3 kDa) were consistently down-regulated in exposed compared with control subjects in both studies. All proteins were highly inversely correlated with individual estimates of benzene exposure (r > 0.75). The 7.7- and 9.3-kDa proteins were subsequently identified as platelet factor (PF)4 and connective tissue activating peptide (CTAP)-III. Initial proteomic results for PF4 and CTAP-III were subsequently confirmed in a single experiment using a ProteinChip-array-based immunoassay(Ciphergen Biosystems). The altered expression of the platelet-derived CXC-chemokines (40% and 63% for PF4 and CTAP-III, respectively) could not be explained by changes in absolute platelet counts. Thus, SELDI-TOF analysis of a limited number of exposed and unexposed subjects revealed that lowered expression of PF4 and CTAP-III proteins is a potential biomarker of benzene's early biologic effects and may play a role in the immunosuppressive effects of benzene. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Vermeulen, Roel AU - Lan, Qing AU - Zhang, Luoping AU - Gunn, Laura AU - McCarthy, Diane AU - Woodbury, Ronald L AU - McGuire, Marielena AU - Podust, Vladimir N AU - Li, Guilan AU - Chatterjee, Nilanjan AU - Mu, Ruidong AU - Yin, Songnian AU - Rothman, Nathaniel AU - Smith, Martyn T AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Rockville, MD 20852, USA. vermeulr@mail.nih.gov Y1 - 2005/11/22/ PY - 2005 DA - 2005 Nov 22 SP - 17041 EP - 17046 VL - 102 IS - 47 SN - 0027-8424, 0027-8424 KW - Biomarkers KW - 0 KW - Chemokines, CXC KW - Benzene KW - J64922108F KW - Index Medicus KW - Protein Array Analysis KW - Humans KW - Linear Models KW - Biomarkers -- blood KW - Proteomics KW - Occupational Exposure -- adverse effects KW - Chemokines, CXC -- blood KW - Benzene -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68821798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Decreased+levels+of+CXC-chemokines+in+serum+of+benzene-exposed+workers+identified+by+array-based+proteomics.&rft.au=Vermeulen%2C+Roel%3BLan%2C+Qing%3BZhang%2C+Luoping%3BGunn%2C+Laura%3BMcCarthy%2C+Diane%3BWoodbury%2C+Ronald+L%3BMcGuire%2C+Marielena%3BPodust%2C+Vladimir+N%3BLi%2C+Guilan%3BChatterjee%2C+Nilanjan%3BMu%2C+Ruidong%3BYin%2C+Songnian%3BRothman%2C+Nathaniel%3BSmith%2C+Martyn+T&rft.aulast=Vermeulen&rft.aufirst=Roel&rft.date=2005-11-22&rft.volume=102&rft.issue=47&rft.spage=17041&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-12 N1 - Date created - 2005-11-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Epidemiol. 1988 Mar;127(3):419-39 [3277397] Environ Health Perspect. 2005 Jun;113(6):801-7 [15929907] Am J Ind Med. 1996 Mar;29(3):236-46 [8833776] J Leukoc Biol. 2000 Apr;67(4):471-8 [10770278] J Biol Chem. 2000 Jul 7;275(27):20374-81 [10877842] Blood. 2000 Nov 1;96(9):2965-72 [11049972] Immunol Rev. 2000 Oct;177:204-16 [11138777] Curr Opin Rheumatol. 2001 May;13(3):202-8 [11333349] Transfus Med. 2001 Dec;11(6):403-17 [11851938] J Immunol. 2002 Jul 15;169(2):770-7 [12097379] Am J Ind Med. 2002 Oct;42(4):275-85 [12271475] Semin Immunol. 2003 Feb;15(1):15-21 [12495637] Lung Cancer. 2003 Jun;40(3):267-79 [12781425] BJU Int. 2003 Aug;92(3):223-5 [12887471] Arch Otolaryngol Head Neck Surg. 2004 Jan;130(1):98-104 [14732777] Ann Occup Hyg. 2004 Mar;48(2):105-16 [14990432] Novartis Found Symp. 2004;256:173-84; discussion 184-8, 259-69 [15027490] Lab Invest. 2004 Jul;84(7):845-56 [15107802] Am J Ind Med. 1985;7(5-6):395-402 [4003402] Toxicol Appl Pharmacol. 1985 Sep 30;80(3):502-10 [2863880] Environ Health Perspect. 1996 Dec;104 Suppl 6:1339-41 [9118917] Environ Health Perspect. 1996 Dec;104 Suppl 6:1349-52 [9118919] Am J Ind Med. 1997 Mar;31(3):287-95 [9055951] Blood. 1997 Apr 1;89(7):2328-35 [9116276] J Natl Cancer Inst. 1997 Jul 16;89(14):1065-71 [9230889] Science. 2004 Dec 3;306(5702):1774-6 [15576619] Stat Med. 1990 Jul;9(7):811-8 [2218183] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Immunohistochemical evaluation of heat shock proteins in normal and preinvasive lesions of the cervix. AN - 68689266; 16112431 AB - Heat Shock Proteins (HSPs) are molecular chaperons with multiple functions relating to cellular homeostasis. Primary, HSPs are expressed in response to cellular stresses that may also include carcinogenesis. Patterns of expression have not been extensively evaluated in the multi-step carcinogenesis of cervical cancer (Normal --> HPV infection --> Cervical Precancer --> Cancer). We evaluated the expression of HSP40, HSP60, HSP70, and HSP90 in normal tissues (N=30), in cervical intraepithelial neoplasia grade 1 (CIN1)(synonymous with productive HPV infections) (N=32), and in CIN3 (cervical precancer)(N=25) by immunohistochemistry staining (graded 0-3) and compared the results to p16INK4a, a biomarker of oncogenic HPV infections and CIN3. We found strong patterns of increased HSP40, HSP60, and HSP70 immunostaining with increasing severity of the lesion in a manner similar to p16INK4a (P(Trend)<0.0005). No difference in staining intensity by grade of lesion was observed for HSP90 (P(Trend)=0.8). Tissue patterns in CIN3 of diffuse immunostaining for HSP40 and HSP70 were analogous to those observed for p16INK4a; HSP60 immunostaining appeared more punctate within cells than for other antigens although similar tissue patterns were observed. We conclude that HSP40, HSP60, and HSP70 expressions are up-regulated in response to the development of CIN3 akin to p16INK4a expression. JF - Cancer letters AU - Castle, Philip E AU - Ashfaq, Raheela AU - Ansari, Faryal AU - Muller, Carolyn Y AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA. castlep@mail.nih.gov Y1 - 2005/11/18/ PY - 2005 DA - 2005 Nov 18 SP - 245 EP - 252 VL - 229 IS - 2 SN - 0304-3835, 0304-3835 KW - Biomarkers, Tumor KW - 0 KW - Cyclin-Dependent Kinase Inhibitor p16 KW - Heat-Shock Proteins KW - Index Medicus KW - Humans KW - Papillomavirus Infections -- complications KW - Precancerous Conditions -- metabolism KW - Precancerous Conditions -- pathology KW - Precancerous Conditions -- virology KW - Cyclin-Dependent Kinase Inhibitor p16 -- biosynthesis KW - Tumor Virus Infections -- metabolism KW - Biomarkers, Tumor -- analysis KW - Up-Regulation KW - Immunohistochemistry KW - Female KW - Papillomavirus Infections -- metabolism KW - Tumor Virus Infections -- complications KW - Cervical Intraepithelial Neoplasia -- pathology KW - Uterine Cervical Neoplasms -- metabolism KW - Cervical Intraepithelial Neoplasia -- metabolism KW - Heat-Shock Proteins -- biosynthesis KW - Cervical Intraepithelial Neoplasia -- virology KW - Uterine Cervical Neoplasms -- pathology KW - Uterine Cervical Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68689266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Immunohistochemical+evaluation+of+heat+shock+proteins+in+normal+and+preinvasive+lesions+of+the+cervix.&rft.au=Castle%2C+Philip+E%3BAshfaq%2C+Raheela%3BAnsari%2C+Faryal%3BMuller%2C+Carolyn+Y&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2005-11-18&rft.volume=229&rft.issue=2&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-11 N1 - Date created - 2005-10-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Potential hazard of pharmacokinetic interactions between lopinavir-ritonavir protease inhibitors and irinotecan AN - 21046234; 6585921 AB - The use of concomitant chemotherapy and highly active antiretroviral therapy (HAART) has been demonstrated to be feasible and effective in reducing morbidity associated with opportunistic infections and to improve overall survival in patients with HIV-related malignances. However, such combination therapy causes severe toxicity, including neutropenia. It has been hypothesized that such unpredictable toxicity can be related to pharmacokinetic interactions. JF - AIDS AU - Corona, G AU - Vaccher, E AU - Cattarossi, G AU - Sartor, I AU - Toffoli, G AD - Division of Medical Oncology A, National Cancer Institute CRO-IRCCS, Aviano (PN), Italy Y1 - 2005/11/18/ PY - 2005 DA - 2005 Nov 18 SP - 2043 EP - 2044 VL - 19 IS - 17 SN - 0269-9370, 0269-9370 KW - HIV KW - irinotecan KW - lopinavir-ritonavir protease inhibitors KW - Immunology Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts; Virology & AIDS Abstracts KW - Acquired immune deficiency syndrome KW - Chemotherapy KW - Proteinase inhibitors KW - Irinotecan KW - Survival KW - Toxicity KW - chemotherapy KW - Pharmacokinetics KW - Morbidity KW - Opportunist infection KW - Neutropenia KW - Human immunodeficiency virus KW - highly active antiretroviral therapy KW - antiretroviral agents KW - infection KW - Side effects KW - X 24114:Metabolism KW - V 22002:AIDS: Molecular and in vitro aspects KW - F 06910:Microorganisms & Parasites KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21046234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Potential+hazard+of+pharmacokinetic+interactions+between+lopinavir-ritonavir+protease+inhibitors+and+irinotecan&rft.au=Corona%2C+G%3BVaccher%2C+E%3BCattarossi%2C+G%3BSartor%2C+I%3BToffoli%2C+G&rft.aulast=Corona&rft.aufirst=G&rft.date=2005-11-18&rft.volume=19&rft.issue=17&rft.spage=2043&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Neutropenia; highly active antiretroviral therapy; Chemotherapy; Irinotecan; Proteinase inhibitors; Survival; Toxicity; Morbidity; Pharmacokinetics; Opportunist infection; Acquired immune deficiency syndrome; antiretroviral agents; infection; Side effects; chemotherapy; Human immunodeficiency virus ER - TY - CPAPER T1 - Production of Reactive Oxygen Species in Both Human and Mouse Mast Cells is Lipoxygenase-Dependent and Plays a Facilitatory Role in Antigen Mediated Cytokine Secretion T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39768844; 4051721 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Coleman, John W AU - Metcalfe, Dean D AU - Swindle, Emily J Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Mast cells KW - Reactive oxygen species KW - Cytokines KW - Secretion KW - Antigens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39768844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Production+of+Reactive+Oxygen+Species+in+Both+Human+and+Mouse+Mast+Cells+is+Lipoxygenase-Dependent+and+Plays+a+Facilitatory+Role+in+Antigen+Mediated+Cytokine+Secretion&rft.au=Coleman%2C+John+W%3BMetcalfe%2C+Dean+D%3BSwindle%2C+Emily+J&rft.aulast=Coleman&rft.aufirst=John&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biting the Hand that Feeds: Use of a Novel DMPO-Protein Antibody in Detection of a Drug-Induced Myeloperoxidase Radical Adduct Upon Myeloperoxidase-Catalyzed Peroxidation of Aminoglutethimide T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39768211; 4051644 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Bonini, Marcelo G AU - Mason, Ronald P AU - Siraki, Arno G Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Feeds KW - Adducts KW - Biting KW - Peroxidation KW - Antibodies KW - Radicals KW - Peroxidase KW - Hand KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39768211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Biting+the+Hand+that+Feeds%3A+Use+of+a+Novel+DMPO-Protein+Antibody+in+Detection+of+a+Drug-Induced+Myeloperoxidase+Radical+Adduct+Upon+Myeloperoxidase-Catalyzed+Peroxidation+of+Aminoglutethimide&rft.au=Bonini%2C+Marcelo+G%3BMason%2C+Ronald+P%3BSiraki%2C+Arno+G&rft.aulast=Bonini&rft.aufirst=Marcelo&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Imaging Tissue Redox Staus Using MRI and Redox Sensitive Paramagnetic Contrast Agents: Applications for Tumor Imaging T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39767150; 4051800 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Hyodo, Fuminori AU - Matsumoto, Ken-ichiro AU - Matsumoto, Atsuko AU - Mitchell, James AU - Murali, Cherukuri AU - Subramanian, Sankaran Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Magnetic resonance imaging KW - Contrast media KW - Redox reactions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39767150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Imaging+Tissue+Redox+Staus+Using+MRI+and+Redox+Sensitive+Paramagnetic+Contrast+Agents%3A+Applications+for+Tumor+Imaging&rft.au=Hyodo%2C+Fuminori%3BMatsumoto%2C+Ken-ichiro%3BMatsumoto%2C+Atsuko%3BMitchell%2C+James%3BMurali%2C+Cherukuri%3BSubramanian%2C+Sankaran&rft.aulast=Hyodo&rft.aufirst=Fuminori&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nitrite Regulates Mitochondrial Respiration and Limits Reperfusion Injury T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39763672; 4052082 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Gladwin, Mark AU - Huang, Zhi AU - Lefer, David AU - Ringwood, Lorna AU - Sack, Michael AU - Shiva, Sruti Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Nitrite KW - Respiration KW - Injuries KW - Mitochondria KW - Reperfusion KW - Electron transport KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39763672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Nitrite+Regulates+Mitochondrial+Respiration+and+Limits+Reperfusion+Injury&rft.au=Gladwin%2C+Mark%3BHuang%2C+Zhi%3BLefer%2C+David%3BRingwood%2C+Lorna%3BSack%2C+Michael%3BShiva%2C+Sruti&rft.aulast=Gladwin&rft.aufirst=Mark&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Catalase Inactivation by Hypochlorite Correlates with Protein Radical Formation, Aggregation and Heme Modification T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39755226; 4051626 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Atanassov, Boyko S AU - Bonini, Marcelo G AU - Mason, Ronald P AU - Siraki, Arno G Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Heme KW - Catalase KW - Radicals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39755226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Catalase+Inactivation+by+Hypochlorite+Correlates+with+Protein+Radical+Formation%2C+Aggregation+and+Heme+Modification&rft.au=Atanassov%2C+Boyko+S%3BBonini%2C+Marcelo+G%3BMason%2C+Ronald+P%3BSiraki%2C+Arno+G&rft.aulast=Atanassov&rft.aufirst=Boyko&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mass Spectral Analysis of Protein-Based Radicals Using Stable Nitroxide Radicals: The Spin Scavenging Approach T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39754566; 4051813 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Deterding, Leesa AU - Lardinois, Olivier AU - Mason, Ronald AU - Tomer, Kenneth Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Radicals KW - Nitroxide KW - Spectral analysis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39754566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Mass+Spectral+Analysis+of+Protein-Based+Radicals+Using+Stable+Nitroxide+Radicals%3A+The+Spin+Scavenging+Approach&rft.au=Deterding%2C+Leesa%3BLardinois%2C+Olivier%3BMason%2C+Ronald%3BTomer%2C+Kenneth&rft.aulast=Deterding&rft.aufirst=Leesa&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Pharmacokinetic Measurement Using Electron Paramagnetic Resonance Spectroscopy and Simulation of in Vivo Decay of Various Nitroxyl Radicals in Mouse Blood T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39750890; 4051805 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Krishna, Murali AU - Matsumoto, Ken-ichiro AU - Mitchell, James Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Decay KW - Blood KW - Spectroscopy KW - Simulation KW - Pharmacokinetics KW - E.S.R. KW - Radicals KW - Resonance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39750890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Novel+Pharmacokinetic+Measurement+Using+Electron+Paramagnetic+Resonance+Spectroscopy+and+Simulation+of+in+Vivo+Decay+of+Various+Nitroxyl+Radicals+in+Mouse+Blood&rft.au=Krishna%2C+Murali%3BMatsumoto%2C+Ken-ichiro%3BMitchell%2C+James&rft.aulast=Krishna&rft.aufirst=Murali&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Atorvastatin Therapy Restores Nitric Oxide-Dependent Vascular Responsiveness in Patients with Sickle Cell Disease T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39750799; 4051778 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Cannon, Richard AU - Dejam, Andre AU - Gladwin, Mark AU - Hunter, Christian AU - Hunter, Lori AU - Kato, Gregory AU - Lin, Elaina AU - Machado, Roberto AU - Mack, Kyle AU - Sachdev, Vandana AU - Tremonti, Carole Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Vascular system KW - Sickle cell disease KW - Atorvastatin KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39750799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Atorvastatin+Therapy+Restores+Nitric+Oxide-Dependent+Vascular+Responsiveness+in+Patients+with+Sickle+Cell+Disease&rft.au=Cannon%2C+Richard%3BDejam%2C+Andre%3BGladwin%2C+Mark%3BHunter%2C+Christian%3BHunter%2C+Lori%3BKato%2C+Gregory%3BLin%2C+Elaina%3BMachado%2C+Roberto%3BMack%2C+Kyle%3BSachdev%2C+Vandana%3BTremonti%2C+Carole&rft.aulast=Cannon&rft.aufirst=Richard&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Noninvasive EPR Assessment of Tissue Oxygenation Using Water Soluble Paramagnetic Probes T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39747266; 4051810 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Devasahayam, Nallathamby AU - Hyodo, Fuminori AU - Koscielniak, Janusz AU - Krishna, Murali AU - Matsumoto, Atsuko AU - Matsumoto, Ken-ichiro AU - Mitchell, James AU - Sowers, Anastasia AU - Subramanian, Sankaran Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Oxygenation KW - Probes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39747266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Noninvasive+EPR+Assessment+of+Tissue+Oxygenation+Using+Water+Soluble+Paramagnetic+Probes&rft.au=Devasahayam%2C+Nallathamby%3BHyodo%2C+Fuminori%3BKoscielniak%2C+Janusz%3BKrishna%2C+Murali%3BMatsumoto%2C+Atsuko%3BMatsumoto%2C+Ken-ichiro%3BMitchell%2C+James%3BSowers%2C+Anastasia%3BSubramanian%2C+Sankaran&rft.aulast=Devasahayam&rft.aufirst=Nallathamby&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Estimation of Redox Status of a Tumor Tissue in Mice Using Paramagnetic Nitroxyl Contrast Agent T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39747239; 4051806 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Cook, John AU - Hyodo, Fuminori AU - Krishna, Murali AU - Matsumoto, Ken-ichiro AU - Matsumoto, Atsuko AU - Mitchell, James AU - Murugesan, Ramachandran AU - Sowers, Anastasia AU - Subramanian, Sankaran Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Mice KW - Contrast media KW - Redox reactions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39747239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Estimation+of+Redox+Status+of+a+Tumor+Tissue+in+Mice+Using+Paramagnetic+Nitroxyl+Contrast+Agent&rft.au=Cook%2C+John%3BHyodo%2C+Fuminori%3BKrishna%2C+Murali%3BMatsumoto%2C+Ken-ichiro%3BMatsumoto%2C+Atsuko%3BMitchell%2C+James%3BMurugesan%2C+Ramachandran%3BSowers%2C+Anastasia%3BSubramanian%2C+Sankaran&rft.aulast=Cook&rft.aufirst=John&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Copper Catalyzed Protein Oxidation and its Modulation by Carbon Dioxide: Enhancement of Protein Radicals in Functioning Cells T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39720913; 4052037 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Mejiba, Sandra Gomez AU - Mason, Ronald AU - Ramirez, Dario Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Copper KW - Oxidation KW - Carbon dioxide KW - Radicals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39720913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Copper+Catalyzed+Protein+Oxidation+and+its+Modulation+by+Carbon+Dioxide%3A+Enhancement+of+Protein+Radicals+in+Functioning+Cells&rft.au=Mejiba%2C+Sandra+Gomez%3BMason%2C+Ronald%3BRamirez%2C+Dario&rft.aulast=Mejiba&rft.aufirst=Sandra&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Superoxide Fluxes Control NO-Induced Post-Translational Regulation of sGC, p53, and HIF-1a T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39712942; 4051917 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Thomas, Douglas AU - Wink, David Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Hypoxia-inducible factor 1^a KW - P53 protein KW - Superoxide KW - Post-translation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39712942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Superoxide+Fluxes+Control+NO-Induced+Post-Translational+Regulation+of+sGC%2C+p53%2C+and+HIF-1a&rft.au=Thomas%2C+Douglas%3BWink%2C+David&rft.aulast=Thomas&rft.aufirst=Douglas&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hydroethidine is Efficiently Oxidized by Singlet Oxygen T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39712257; 4051796 DE: JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Bilski, Piotr AU - Chignell, Colin F AU - DeRose, Eugene F AU - Karriker, Brian Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39712257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Hydroethidine+is+Efficiently+Oxidized+by+Singlet+Oxygen&rft.au=Bilski%2C+Piotr%3BChignell%2C+Colin+F%3BDeRose%2C+Eugene+F%3BKarriker%2C+Brian&rft.aulast=Bilski&rft.aufirst=Piotr&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proteomic Identification of Dysregulated Apolipoprotein Expression in Pulmonary Hypertension Secondary to Sickle Cell Disease T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39712164; 4051777 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Gladwin, Mark AU - Hoehn, Gerard AU - Kato, Gregory AU - Munson, Peter AU - Suffredini, Anthony AU - Xu, Xiuli AU - Yuditskaya, Susan Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Hypertension KW - Apolipoproteins KW - Proteomics KW - Sickle cell disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39712164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Proteomic+Identification+of+Dysregulated+Apolipoprotein+Expression+in+Pulmonary+Hypertension+Secondary+to+Sickle+Cell+Disease&rft.au=Gladwin%2C+Mark%3BHoehn%2C+Gerard%3BKato%2C+Gregory%3BMunson%2C+Peter%3BSuffredini%2C+Anthony%3BXu%2C+Xiuli%3BYuditskaya%2C+Susan&rft.aulast=Gladwin&rft.aufirst=Mark&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nitroxides Inhibit the TNF-Alpha Initiated NF-kB Cytoplasmic to Nuclear Translocation T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39709074; 4051867 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Cook, John AU - Grimes, Kelly AU - Mitchell, James Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - NF-^KB protein KW - Nuclear transport KW - Nitroxide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39709074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Nitroxides+Inhibit+the+TNF-Alpha+Initiated+NF-kB+Cytoplasmic+to+Nuclear+Translocation&rft.au=Cook%2C+John%3BGrimes%2C+Kelly%3BMitchell%2C+James&rft.aulast=Cook&rft.aufirst=John&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammatory stress. AN - 68805004; 16288013 AB - Activation of the p53 network plays a central role in the inflammatory stress response associated with ulcerative colitis and may modulate cancer risk in patients afflicted with this chronic disease. Here, we describe the gene expression profiles associated with four microenvironmental components of the inflammatory response (NO*, H2O2, DNA replication arrest, and hypoxia) that result in p53 stabilization and activation. Isogenic HCT116 and HCT116 TP53-/- colon cancer cells were exposed to the NO* donor Sper/NO, H2O2, hypoxia, or hydroxyurea, and their mRNA was analyzed using oligonucleotide microarrays. Overall, 1,396 genes changed in a p53-dependent manner (P < 0.001), with the majority representing a "unique" profile for each condition. Only 14 genes were common to all four conditions. Included were eight known p53 target genes. Hierarchical sample clustering distinguished early (1 and 4 hours) from late responses (8, 12, and 24 hours), and each treatment was differentiated from the others. Overall, NO* and hypoxia stimulated similar transcriptional responses. Gene ontology analysis revealed cell cycle as a key feature of stress responses and confirmed the similarity between NO* and hypoxia. Cell cycle profiles analyzed by flow cytometry showed that NO* and hypoxia induced quiescent S-phase and G2-M arrest. Using a novel bioinformatic algorithm, we identified several putative p53-responsive elements among the genes induced in a p53-dependent manner, including four [KIAA0247, FLJ12484, p53CSV (HSPC132), and CNK (PLK3)] common to all exposures. In summary, the inflammatory stress response is a complex, integrated biological network in which p53 is a key molecular node regulating gene expression. JF - Cancer research AU - Staib, Frank AU - Robles, Ana I AU - Varticovski, Lyuba AU - Wang, Xin W AU - Zeeberg, Barry R AU - Sirotin, Michail AU - Zhurkin, Victor B AU - Hofseth, Lorne J AU - Hussain, S Perwez AU - Weinstein, John N AU - Galle, Peter R AU - Harris, Curtis C AD - Laboratories of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, USA. Y1 - 2005/11/15/ PY - 2005 DA - 2005 Nov 15 SP - 10255 EP - 10264 VL - 65 IS - 22 SN - 0008-5472, 0008-5472 KW - Nitric Oxide Donors KW - 0 KW - Nitrogen Oxides KW - TP53 protein, human KW - Tumor Suppressor Protein p53 KW - spermine nitric oxide complex KW - 136587-13-8 KW - Spermine KW - 2FZ7Y3VOQX KW - Hydrogen Peroxide KW - BBX060AN9V KW - Index Medicus KW - Humans KW - Oxidative Stress -- genetics KW - HCT116 Cells KW - Cell Hypoxia KW - Reverse Transcriptase Polymerase Chain Reaction KW - Gene Expression Profiling KW - Oxidative Stress -- physiology KW - Spermine -- analogs & derivatives KW - Flow Cytometry KW - Cell Cycle KW - Tumor Suppressor Protein p53 -- biosynthesis KW - Inflammation -- etiology KW - Inflammation -- genetics KW - Inflammation -- metabolism KW - Tumor Suppressor Protein p53 -- genetics KW - Tumor Suppressor Protein p53 -- metabolism KW - Tumor Suppressor Protein p53 -- deficiency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68805004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=The+p53+tumor+suppressor+network+is+a+key+responder+to+microenvironmental+components+of+chronic+inflammatory+stress.&rft.au=Staib%2C+Frank%3BRobles%2C+Ana+I%3BVarticovski%2C+Lyuba%3BWang%2C+Xin+W%3BZeeberg%2C+Barry+R%3BSirotin%2C+Michail%3BZhurkin%2C+Victor+B%3BHofseth%2C+Lorne+J%3BHussain%2C+S+Perwez%3BWeinstein%2C+John+N%3BGalle%2C+Peter+R%3BHarris%2C+Curtis+C&rft.aulast=Staib&rft.aufirst=Frank&rft.date=2005-11-15&rft.volume=65&rft.issue=22&rft.spage=10255&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-18 N1 - Date created - 2005-11-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: BMC Bioinformatics. 2005;6:168 [15998470] Nature. 2005 Apr 28;434(7037):1138-43 [15858576] J Leukoc Biol. 1999 Dec;66(6):889-900 [10614769] Circ Res. 2000 Feb 18;86(3):319-25 [10679484] Genes Dev. 2000 Apr 15;14(8):981-93 [10783169] Cancer Res. 2000 Jul 1;60(13):3333-7 [10910033] Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12770-5 [11050162] Nature. 2000 Nov 16;408(6810):307-10 [11099028] J Biol Chem. 2001 Nov 23;276(47):43604-10 [11571296] Jpn J Cancer Res. 2001 Nov;92(11):1166-74 [11714440] Acta Oncol. 2001;40(6):696-701 [11765063] Mol Cell Biol. 2002 Mar;22(6):1834-43 [11865061] J Korean Med Sci. 2002 Oct;17(5):581-8 [12378005] Brain Res Mol Brain Res. 2002 Oct 30;107(1):9-16 [12414118] Cancer Res. 2002 Nov 1;62(21):6246-54 [12414654] Free Radic Biol Med. 2002 Nov 15;33(10):1419-32 [12419474] Nature. 2002 Dec 19-26;420(6917):860-7 [12490959] Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):143-8 [12518062] Nat Rev Cancer. 2003 Apr;3(4):276-85 [12671666] Curr Med Chem. 2003 May;10(10):845-55 [12678687] Free Radic Biol Med. 2003 Apr 15;34(8):955-68 [12684081] Bioessays. 2003 May;25(5):501-6 [12717820] Cell Death Differ. 2003 Apr;10(4):404-8 [12719716] Nature. 2003 May 15;423(6937):302-5 [12714971] Oncogene. 2003 Jun 5;22(23):3645-54 [12789273] Oncogene. 2003 Sep 1;22(37):5907-14 [12947397] Cancer Biol Ther. 2003 Jul-Aug;2(4):406-15 [14508115] Mutat Res. 2003 Nov 27;532(1-2):205-13 [14643437] J Clin Invest. 2003 Dec;112(12):1887-94 [14679184] J Biol Chem. 2004 Jan 23;279(4):2550-8 [14600153] Cancer Lett. 2004 Jan 20;203(2):217-24 [14732230] Free Radic Biol Med. 2004 Feb 15;36(4):507-16 [14975453] Trends Pharmacol Sci. 2004 Apr;25(4):177-81 [15116721] Cancer Res. 2004 May 1;64(9):3022-9 [15126337] J Biol Chem. 2004 Jun 11;279(24):25093-100 [15044452] Annu Rev Biochem. 2004;73:39-85 [15189136] Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8894-9 [15178764] Med Hypotheses. 1979 Sep;5(9):937-51 [522709] Proc Natl Acad Sci U S A. 1989 Feb;86(4):1183-7 [2919167] Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5258-65 [7777494] J Exp Med. 1995 Dec 1;182(6):1683-93 [7500013] Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2442-7 [8637893] J Clin Microbiol. 1996 Jul;34(7):1646-8 [8784562] Am J Physiol. 1998 Feb;274(2 Pt 1):L212-9 [9486205] Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8823-8 [9671763] Cancer J Sci Am. 1998 Jul-Aug;4(4):218-23 [9689978] Cell Mol Life Sci. 1998 Jul;54(7):684-95 [9711234] Curr Mol Med. 2004 Nov;4(7):741-51 [15579021] Toxicology. 2005 Mar 15;208(2):223-33 [15691587] Oncogene. 2005 Mar 3;24(10):1738-48 [15674334] Int J Radiat Oncol Biol Phys. 1999 Nov 1;45(4):1019-24 [10571211] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Yin-yang: balancing act of prostaglandins with opposing functions to regulate inflammation. AN - 68765371; 16272277 AB - For many years, cyclooxygenase-2 (COX-2), a critical enzyme for PG production, has been the favorite target for anti-inflammatory drug development. However, recent revelations regarding the adverse effects of selective COX-2 inhibitors have stimulated intense debate. Interestingly, in the early phase of inflammation, COX-2 facilitates inflammatory PG production while in the late phase it has anti-inflammatory effects. Moreover, although some PGs are proinflammatory, others have anti-inflammatory effects. Thus, it is likely that PGs with opposing effects maintain homeostasis, although the molecular mechanism(s) remains unclear. We report here that an inflammatory PG, PGD2, via its receptor, mediates the activation of NF-kappaB stimulating COX-2 gene expression. Most interestingly, an anti-inflammatory PG (PGA1) suppresses NF-kappaB activation and inhibits COX-2 gene expression. We propose that while pro- and anti-inflammatory PGs counteract each other to maintain homeostasis, selective COX-2 inhibitors may disrupt this balance, thereby resulting in reported adverse effects. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Mandal, Asim K AU - Zhang, Zhongjian AU - Kim, Sung-Jo AU - Tsai, Pei-Chih AU - Mukherjee, Anil B AD - Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2005/11/15/ PY - 2005 DA - 2005 Nov 15 SP - 6271 EP - 6273 VL - 175 IS - 10 SN - 0022-1767, 0022-1767 KW - Cyclooxygenase 2 Inhibitors KW - 0 KW - NF-kappa B KW - Prostaglandins KW - Prostaglandins A KW - RNA, Messenger KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - Prostaglandin D2 KW - RXY07S6CZ2 KW - prostaglandin A1 KW - VYR271N44P KW - Abridged Index Medicus KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Cyclooxygenase 2 -- physiology KW - Cyclooxygenase 2 Inhibitors -- adverse effects KW - Prostaglandins A -- pharmacology KW - Cyclooxygenase 2 -- genetics KW - Cyclooxygenase 2 Inhibitors -- pharmacology KW - Mice KW - RNA, Messenger -- genetics KW - Homeostasis -- drug effects KW - NF-kappa B -- genetics KW - NIH 3T3 Cells KW - Prostaglandin D2 -- pharmacology KW - RNA, Messenger -- metabolism KW - NF-kappa B -- metabolism KW - Prostaglandins -- physiology KW - Inflammation -- physiopathology KW - Inflammation -- genetics KW - Inflammation -- drug therapy KW - Inflammation -- immunology KW - Prostaglandins -- immunology KW - Prostaglandins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68765371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Yin-yang%3A+balancing+act+of+prostaglandins+with+opposing+functions+to+regulate+inflammation.&rft.au=Mandal%2C+Asim+K%3BZhang%2C+Zhongjian%3BKim%2C+Sung-Jo%3BTsai%2C+Pei-Chih%3BMukherjee%2C+Anil+B&rft.aulast=Mandal&rft.aufirst=Asim&rft.date=2005-11-15&rft.volume=175&rft.issue=10&rft.spage=6271&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-03 N1 - Date created - 2005-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The antileukemia effect of HLA-matched NK and NK-T cells in chronic myelogenous leukemia involves NKG2D-target-cell interactions. AN - 68755532; 16046526 AB - To study natural killer (NK) cell-mediated antileukemic activity in chronic myelogenous leukemia (CML), we investigated the ability of HLA-matched and mismatched CD56(+) cells to inhibit granulocyte macrophage-colony-forming unit (CFU-GM) formation by leukemic CD34(+) cells. In 14 HLA-identical donor-recipient pairs, donor CD56(+) cells inhibited CML CFU-GM comparably to effectors from 14 HLA-mismatched unrelated individuals (mean inhibition 42% +/- 9% vs 39.5% +/- 7% at a 10:1 effector-to-target (E/T) ratio), suggesting that killer inhibitory receptor (KIR) incompatibility was not essential for an antileukemic effect. Both CD56(+)CD3(-) (natural killer [NK]) and CD56(+)CD3(+)(NK-T) cells inhibited CFU-GM growth of CML but not normal CD34(+) cells. A mechanism for this leukemia-specific cytotoxicity was suggested by the abnormal overexpression of major histocompatibility class I chain-related gene A or gene B (MICA/B) on CML CD34 cells and their ability to bind the NK activation ligand NKG2D. However, in vivo, CML cells may avoid NK-cell-mediated immune destruction by immune escape, shedding MICA into the plasma, thereby down-regulating NKG2D on CML CD56(+) cells. JF - Blood AU - Sconocchia, Giuseppe AU - Lau, Michelle AU - Provenzano, Maurizio AU - Rezvani, Katayoun AU - Wongsena, Wachanan AU - Fujiwara, Hiroshi AU - Hensel, Nancy AU - Melenhorst, Jos AU - Li, Jonming AU - Ferrone, Soldano AU - Barrett, A John AD - Stem Cell Allotransplantation Section, Hematology Branch, National Heart Lung and Blood Institute, Department of Transfusion Medicine, Clinical Center, National Institutes of Health (NIH), Bethesda, MD 20892, USA. Y1 - 2005/11/15/ PY - 2005 DA - 2005 Nov 15 SP - 3666 EP - 3672 VL - 106 IS - 10 SN - 0006-4971, 0006-4971 KW - Antigens, CD KW - 0 KW - HLA Antigens KW - Histocompatibility Antigens Class I KW - KLRK1 protein, human KW - MHC class I-related chain A KW - MICB antigen KW - NK Cell Lectin-Like Receptor Subfamily K KW - Receptors, Immunologic KW - Receptors, Natural Killer Cell KW - Abridged Index Medicus KW - Index Medicus KW - Cytotoxicity Tests, Immunologic -- methods KW - Humans KW - Histocompatibility Antigens Class I -- immunology KW - Tumor Cells, Cultured KW - Histocompatibility Testing -- methods KW - Adult KW - Case-Control Studies KW - HLA Antigens -- immunology KW - Antigens, CD -- immunology KW - Female KW - Male KW - Receptors, Immunologic -- immunology KW - Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- immunology KW - Neoplastic Stem Cells -- immunology KW - T-Lymphocytes -- immunology KW - Killer Cells, Natural -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68755532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=The+antileukemia+effect+of+HLA-matched+NK+and+NK-T+cells+in+chronic+myelogenous+leukemia+involves+NKG2D-target-cell+interactions.&rft.au=Sconocchia%2C+Giuseppe%3BLau%2C+Michelle%3BProvenzano%2C+Maurizio%3BRezvani%2C+Katayoun%3BWongsena%2C+Wachanan%3BFujiwara%2C+Hiroshi%3BHensel%2C+Nancy%3BMelenhorst%2C+Jos%3BLi%2C+Jonming%3BFerrone%2C+Soldano%3BBarrett%2C+A+John&rft.aulast=Sconocchia&rft.aufirst=Giuseppe&rft.date=2005-11-15&rft.volume=106&rft.issue=10&rft.spage=3666&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-15 N1 - Date created - 2005-11-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Exp Med. 2000 Apr 17;191(8):1259-62 [10770793] Neoplasia. 2004 Sep-Oct;6(5):558-68 [15548365] Crit Rev Immunol. 2000;20(3):223-44 [10968372] Immunity. 2001 Feb;14(2):123-33 [11239445] Nat Immunol. 2001 Mar;2(3):255-60 [11224526] Immunol Rev. 2001 Jun;181:158-69 [11513137] Immunol Rev. 2001 Jun;181:185-92 [11513139] Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11521-6 [11562472] Cancer Res. 2002 Nov 1;62(21):6178-86 [12414645] Int J Hematol. 2002 Aug;76 Suppl 2:155-61 [12430918] Hum Immunol. 2003 Feb;64(2):183-93 [12559621] Blood. 2003 Aug 1;102(3):814-9 [12689936] Blood. 2003 Aug 15;102(4):1389-96 [12714493] J Immunol. 2003 Dec 15;171(12):6891-9 [14662896] Nature. 1975 Aug 7;256(5517):495-7 [1172191] Br J Cancer. 1983 Oct;48(4):507-14 [6626451] J Immunol. 1986 Jun 15;136(12):4480-6 [3086432] J Exp Med. 1986 Sep 1;164(3):814-25 [3489062] J Immunol Methods. 1987 Jun 26;100(1-2):83-90 [3298442] Blood. 1990 Jun 1;75(11):2250-62 [2189508] Leukemia. 1990 Apr;4(4):287-91 [2366584] Blood. 1990 Nov 15;76(10):2037-45 [2242425] Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7983-5 [1518825] Bone Marrow Transplant. 1993 Feb;11(2):133-8 [8435662] Med Clin (Barc). 1995 Jun 10;105(2):50-3 [7603094] Blood. 1996 Mar 15;87(6):2476-85 [8630414] Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12445-50 [8901601] Blood. 1997 Feb 1;89(3):957-64 [9028327] Ann Hematol. 1997 Jan;74(1):1-6 [9031607] Blood. 1998 Nov 1;92(9):3318-27 [9787169] Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6879-84 [10359807] Blood. 1999 Jul 1;94(1):333-9 [10381530] Science. 1999 Jul 30;285(5428):727-9 [10426993] Immunol Today. 2000 May;21(5):228-34 [10782054] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Breast cancer risk following radiotherapy for Hodgkin lymphoma: modification by other risk factors. AN - 68755152; 16051739 AB - The importance of genetic and other risk factors in the development of breast cancer after radiotherapy (RT) for Hodgkin lymphoma (HL) has not been determined. We analyzed data from a breast cancer case-control study (105 patients, 266 control subjects) conducted among 3 817 survivors of HL diagnosed at age 30 years or younger in 6 population-based cancer registries. Odds ratios (ORs) and excess relative risks (ERRs) were calculated using conditional regression. Women who received RT exposure (> or = 5 Gy radiation dose to the breast) had a 2.7-fold increased breast cancer risk (95% confidence interval (CI) 1.4-5.2), compared with those given less than 5 Gy. RT exposure (> or = 5 Gy) was associated with an OR of 0.8 (95% CI, 0.2-3.4) among women with a first- or second-degree family history of breast or ovarian cancer, and 5.8 (95% CI, 2.1-16.3) among all other women (interaction P = .03). History of a live birth appeared to increase the breast cancer risk associated with RT among women not treated with ovarian-damaging therapies. Breast cancer risk following RT varied little according to other factors. The additional increased relative risk of breast cancer after RT for HL is unlikely to be larger among women with a family history of breast or ovarian cancer than among other women. JF - Blood AU - Hill, Deirdre A AU - Gilbert, Ethel AU - Dores, Graça M AU - Gospodarowicz, Mary AU - van Leeuwen, Flora E AU - Holowaty, Eric AU - Glimelius, Bengt AU - Andersson, Michael AU - Wiklund, Tom AU - Lynch, Charles F AU - Van't Veer, Mars AU - Storm, Hans AU - Pukkala, Eero AU - Stovall, Marilyn AU - Curtis, Rochelle E AU - Allan, James M AU - Boice, John D AU - Travis, Lois B AD - Division of Cancer Epidemiology and Genetics and Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. dahill@salud.unm.edu Y1 - 2005/11/15/ PY - 2005 DA - 2005 Nov 15 SP - 3358 EP - 3365 VL - 106 IS - 10 SN - 0006-4971, 0006-4971 KW - Abridged Index Medicus KW - Index Medicus KW - Odds Ratio KW - Risk Factors KW - Radiotherapy Dosage KW - Humans KW - Adult KW - Retrospective Studies KW - Middle Aged KW - Female KW - Hodgkin Disease -- radiotherapy KW - Breast Neoplasms -- mortality KW - Neoplasms, Radiation-Induced -- etiology KW - Neoplasms, Second Primary -- etiology KW - Breast Neoplasms -- etiology KW - Neoplasms, Radiation-Induced -- mortality KW - Neoplasms, Second Primary -- mortality KW - Hodgkin Disease -- complications KW - Hodgkin Disease -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68755152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Breast+cancer+risk+following+radiotherapy+for+Hodgkin+lymphoma%3A+modification+by+other+risk+factors.&rft.au=Hill%2C+Deirdre+A%3BGilbert%2C+Ethel%3BDores%2C+Gra%C3%A7a+M%3BGospodarowicz%2C+Mary%3Bvan+Leeuwen%2C+Flora+E%3BHolowaty%2C+Eric%3BGlimelius%2C+Bengt%3BAndersson%2C+Michael%3BWiklund%2C+Tom%3BLynch%2C+Charles+F%3BVan%27t+Veer%2C+Mars%3BStorm%2C+Hans%3BPukkala%2C+Eero%3BStovall%2C+Marilyn%3BCurtis%2C+Rochelle+E%3BAllan%2C+James+M%3BBoice%2C+John+D%3BTravis%2C+Lois+B&rft.aulast=Hill&rft.aufirst=Deirdre&rft.date=2005-11-15&rft.volume=106&rft.issue=10&rft.spage=3358&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-15 N1 - Date created - 2005-11-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Lancet. 2001 Oct 27;358(9291):1389-99 [11705483] Cancer Causes Control. 1994 Mar;5(2):167-76 [8167264] J Clin Oncol. 2002 Aug 15;20(16):3484-94 [12177110] Clin Cancer Res. 2002 Dec;8(12):3813-9 [12473594] Cancer Epidemiol Biomarkers Prev. 2003 Apr;12(4):289-94 [12692102] Cancer Causes Control. 2003 Mar;14(2):151-60 [12749720] J Natl Cancer Inst. 2003 Jul 2;95(13):971-80 [12837833] JAMA. 2003 Jul 23;290(4):465-75 [12876089] Mol Cell. 2003 Nov;12(5):1087-99 [14636569] J Clin Oncol. 2003 Dec 1;21(23):4386-94 [14645429] Radiat Res. 2003 Dec;160(6):707-17 [14640793] Blood. 2004 Jan 1;103(1):283-90 [12969974] Epidemiology. 2004 Jul;15(4):422-7 [15232402] J Natl Cancer Inst. 1980 Jun;64(6):1459-66 [6929382] Prev Med. 1980 Nov;9(6):815-22 [7454704] N Engl J Med. 1994 Jul 7;331(1):5-9 [8202106] BMJ. 1994 Jun 25;308(6945):1672-4 [8025460] J Natl Cancer Inst Monogr. 1994;(16):15-24 [7999458] Br J Cancer. 1995 Aug;72(2):480-4 [7640236] Science. 1999 Nov 5;286(5442):1162-6 [10550055] J Clin Oncol. 1999 Apr;17(4):1259 [10561187] Cancer Epidemiol Biomarkers Prev. 1999 Dec;8(12):1043-50 [10613335] Carcinogenesis. 2000 May;21(5):1043-50 [10783331] Int J Radiat Biol. 2000 May;76(5):693-8 [10866292] Am J Epidemiol. 2000 Sep 15;152(6):514-27 [10997541] Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5134-9 [11320250] Br J Cancer. 2001 Aug 3;85(3):362-6 [11487266] Cancer Causes Control. 1995 Jul;6(4):283-91 [7548715] J Natl Cancer Inst. 1996 Mar 20;88(6):359-64 [8609645] Radiat Res. 1996 Jun;145(6):708-13 [8643830] Nature. 1997 Apr 24;386(6627):804-10 [9126738] Am J Hum Genet. 1998 Feb;62(2):334-45 [9463314] J Clin Oncol. 1998 Jul;16(7):2417-25 [9667259] J Natl Cancer Inst. 1999 Jun 2;91(11):943-9 [10359546] Cancer. 1983 Aug 1;52(3):435-8 [6688036] J Natl Cancer Inst. 1986 Sep;77(3):689-96 [3462410] Int J Cancer. 1989 Jul 15;44(1):7-16 [2744900] Arch Intern Med. 1990 Jan;150(1):191-4 [2297287] Br J Cancer. 1990 Jul;62(1):122-6 [2390471] N Engl J Med. 1992 Mar 19;326(12):781-5 [1538720] J Natl Cancer Inst. 1992 Aug 19;84(16):1245-50 [1640483] J Natl Cancer Inst. 1993 Oct 20;85(20):1679-85 [8411245] Int J Cancer. 1994 Feb 1;56(3):413-7 [8314329] Int J Cancer. 1994 Mar 15;56(6):793-801 [8119768] Radiat Res. 2002 Aug;158(2):220-35 [12105993] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Autonomic activity in relation to symptom ratings and reaction time in unmedicated patients with schizophrenia. AN - 68721907; 16006104 AB - High autonomic base levels and low responsivity are frequently observed in unmedicated patients with schizophrenia. We previously reported that patients in the present cohort, compared to normal controls, had high autonomic tonic baselines and low reactivity to the meaningful stimuli in a reaction time (RT) task but not to novel but innocuous stimuli. This paper explores further the role of autonomic activity in the pathogenesis of schizophrenia by relating differences in the autonomic variables among patients to symptom ratings and RT. Electrodermal activity and heart rate were recorded during rest, a tone series, and a RT task in 73 patients with schizophrenia taking placebo. Symptoms were rated with the Brief Psychiatric Rating Scale. Patients with higher autonomic baselines both at rest and under mild stress and those with greater electrodermal responsivity to both simple tones and the RT stimuli had more severe positive, "active", and total symptoms than patients with lower baselines and responsivity. RT was slower in patients with higher baselines. High autonomic activity in general, reactivity as well as base levels, under all conditions used in this study was associated with symptom severity independent of differences from controls. Thus elevated autonomic activity and responsivity may themselves be disturbing or index states that are disturbing in schizophrenia. Some patients might attempt to cope with novel or demanding situations and stimuli by a passive-avoidant strategy of low attention and effort in order to attenuate their responsivity. Less symptomatic patients may better cope in this manner. JF - Schizophrenia research AU - Zahn, Theodore P AU - Pickar, David AD - Laboratory of Brain and Cognition, National Institutes of Health, Bldg. 10. Rm. 4C104, MSC 1366, Bethesda, MD 20892-1366, USA. tpz@mail.nih.gov Y1 - 2005/11/15/ PY - 2005 DA - 2005 Nov 15 SP - 257 EP - 270 VL - 79 IS - 2-3 SN - 0920-9964, 0920-9964 KW - Index Medicus KW - Depression -- physiopathology KW - Analysis of Variance KW - Humans KW - Retrospective Studies KW - Anxiety -- physiopathology KW - Reflex, Startle -- physiology KW - Dose-Response Relationship, Radiation KW - Acoustic Stimulation -- methods KW - Depression -- etiology KW - Adult KW - Cohort Studies KW - Heart Rate -- physiology KW - Reflex, Startle -- radiation effects KW - Male KW - Anxiety -- etiology KW - Female KW - Functional Laterality KW - Galvanic Skin Response -- physiology KW - Brief Psychiatric Rating Scale -- statistics & numerical data KW - Autonomic Nervous System -- physiopathology KW - Schizophrenia -- physiopathology KW - Schizophrenia -- complications KW - Reaction Time -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68721907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Schizophrenia+research&rft.atitle=Autonomic+activity+in+relation+to+symptom+ratings+and+reaction+time+in+unmedicated+patients+with+schizophrenia.&rft.au=Zahn%2C+Theodore+P%3BPickar%2C+David&rft.aulast=Zahn&rft.aufirst=Theodore&rft.date=2005-11-15&rft.volume=79&rft.issue=2-3&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Schizophrenia+research&rft.issn=09209964&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-14 N1 - Date created - 2005-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Polymorphisms of the Toll-Like Receptors and Human Disease AN - 17080627; 6707956 AB - The Toll-like receptor (TLR) family regulates both innate and adaptive immune responses. Given its broad effect on immunity, the function of TLRs in various human diseases has been investigated largely by comparing the incidence of disease among persons with different polymorphisms in the genes that participate in TLR signaling. These studies demonstrate that TLR function affects several diseases, including sepsis, immunodeficiencies, atherosclerosis, and asthma. These findings have resulted in new opportunities to study the pathogenesis of disease, identify subpopulations at greater risk of disease, and, potentially, identify novel therapeutic approaches. JF - Clinical Infectious Diseases AU - Schwartz, DA AU - Cook, D N AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA Y1 - 2005/11/15/ PY - 2005 DA - 2005 Nov 15 SP - S403 EP - S407 VL - 41 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Risk assessment KW - Sepsis KW - Gene polymorphism KW - Subpopulations KW - Immunodeficiency KW - Asthma KW - Arteriosclerosis KW - Immunity KW - Immune response KW - Toll-like receptors KW - Signal transduction KW - J 02350:Immunology KW - F 06950:Immunogenetics, MHC, HLA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17080627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Polymorphisms+of+the+Toll-Like+Receptors+and+Human+Disease&rft.au=Schwartz%2C+DA%3BCook%2C+D+N&rft.aulast=Schwartz&rft.aufirst=DA&rft.date=2005-11-15&rft.volume=41&rft.issue=&rft.spage=S403&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Risk assessment; Sepsis; Subpopulations; Gene polymorphism; Immunodeficiency; Asthma; Immune response; Immunity; Arteriosclerosis; Toll-like receptors; Signal transduction ER - TY - CPAPER T1 - Live Cell-Based Assays for Compound Screening T2 - Second Annual Conference on Fluorescent Proteins for Cellular Imaging and Drug Development AN - 40129077; 4041394 JF - Second Annual Conference on Fluorescent Proteins for Cellular Imaging and Drug Development AU - Inglese, James Y1 - 2005/11/14/ PY - 2005 DA - 2005 Nov 14 KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40129077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+Annual+Conference+on+Fluorescent+Proteins+for+Cellular+Imaging+and+Drug+Development&rft.atitle=Live+Cell-Based+Assays+for+Compound+Screening&rft.au=Inglese%2C+James&rft.aulast=Inglese&rft.aufirst=James&rft.date=2005-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+Annual+Conference+on+Fluorescent+Proteins+for+Cellular+Imaging+and+Drug+Development&rft.issn=&rft_id=info:doi/ L2 - http://www.healthtech.com/2005/gfp/index.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Frontiers in Fluorescent Protein Imaging in Living Cells T2 - Second Annual Conference on Fluorescent Proteins for Cellular Imaging and Drug Development AN - 40110722; 4041388 JF - Second Annual Conference on Fluorescent Proteins for Cellular Imaging and Drug Development AU - Patterson, George Y1 - 2005/11/14/ PY - 2005 DA - 2005 Nov 14 KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40110722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+Annual+Conference+on+Fluorescent+Proteins+for+Cellular+Imaging+and+Drug+Development&rft.atitle=Frontiers+in+Fluorescent+Protein+Imaging+in+Living+Cells&rft.au=Patterson%2C+George&rft.aulast=Patterson&rft.aufirst=George&rft.date=2005-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+Annual+Conference+on+Fluorescent+Proteins+for+Cellular+Imaging+and+Drug+Development&rft.issn=&rft_id=info:doi/ L2 - http://www.healthtech.com/2005/gfp/index.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis and Application of RNAi against Cancer Associated Genes T2 - AACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications AN - 40055475; 4016049 JF - AACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications AU - Caplen, Natasha Y1 - 2005/11/14/ PY - 2005 DA - 2005 Nov 14 KW - RNA-mediated interference KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40055475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=AACR-NCI-EORTC+Conference+on+Molecular+Targets+and+Cancer+Therapeutics%3A+Discovery%2C+Biology%2C+and+Clinical+Applications&rft.atitle=Analysis+and+Application+of+RNAi+against+Cancer+Associated+Genes&rft.au=Caplen%2C+Natasha&rft.aulast=Caplen&rft.aufirst=Natasha&rft.date=2005-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=AACR-NCI-EORTC+Conference+on+Molecular+Targets+and+Cancer+Therapeutics%3A+Discovery%2C+Biology%2C+and+Clinical+Applications&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/page4277.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preclinical Development of Halichondrin B and its Derivative Eisai E7389 T2 - AACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications AN - 40051612; 4016006 JF - AACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications AU - Newman, D J Y1 - 2005/11/14/ PY - 2005 DA - 2005 Nov 14 KW - Drug discovery KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40051612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=AACR-NCI-EORTC+Conference+on+Molecular+Targets+and+Cancer+Therapeutics%3A+Discovery%2C+Biology%2C+and+Clinical+Applications&rft.atitle=Preclinical+Development+of+Halichondrin+B+and+its+Derivative+Eisai+E7389&rft.au=Newman%2C+D+J&rft.aulast=Newman&rft.aufirst=D&rft.date=2005-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=AACR-NCI-EORTC+Conference+on+Molecular+Targets+and+Cancer+Therapeutics%3A+Discovery%2C+Biology%2C+and+Clinical+Applications&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/page4277.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MMP2 Activates TGF-ss1 and Augments TssRII Signaling within the Aged Arterial Wall: Relevance to Matrix Deposition with Aging T2 - 2005 Scientific Sessions of the American Heart Association AN - 40004478; 4110583 JF - 2005 Scientific Sessions of the American Heart Association AU - Wang, Mingyi AU - Zhao, Di AU - Spinetti, Gaia AU - Zhang, Jing AU - Jiang, Li-Qun AU - Pintus, Gianfranco AU - Monticone, Robert E AU - Lakatta, Edward G Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Aging KW - Signal transduction KW - Gelatinase A KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40004478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=MMP2+Activates+TGF-ss1+and+Augments+TssRII+Signaling+within+the+Aged+Arterial+Wall%3A+Relevance+to+Matrix+Deposition+with+Aging&rft.au=Wang%2C+Mingyi%3BZhao%2C+Di%3BSpinetti%2C+Gaia%3BZhang%2C+Jing%3BJiang%2C+Li-Qun%3BPintus%2C+Gianfranco%3BMonticone%2C+Robert+E%3BLakatta%2C+Edward+G&rft.aulast=Wang&rft.aufirst=Mingyi&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Indices of Ventricular Relaxation are Not Related to Objective Measures of Exercise Capacity in Non-Obstructive Hypertrophic Cardiomyopathy T2 - 2005 Scientific Sessions of the American Heart Association AN - 39960896; 4109006 JF - 2005 Scientific Sessions of the American Heart Association AU - Owens, David S AU - Arena, Ross A AU - Smith, Kevin AU - Mohiddin, Saidi A AU - McAreavey, Dorothea AU - Bacharach, Steve L AU - Ulisney, Karen L AU - Fananapazir, Lameh AU - Hadi, Mohiuddin AU - Plehn, Jonathan F Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Cardiomyopathy KW - Physical training KW - Circulatory system KW - Heart KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39960896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Indices+of+Ventricular+Relaxation+are+Not+Related+to+Objective+Measures+of+Exercise+Capacity+in+Non-Obstructive+Hypertrophic+Cardiomyopathy&rft.au=Owens%2C+David+S%3BArena%2C+Ross+A%3BSmith%2C+Kevin%3BMohiddin%2C+Saidi+A%3BMcAreavey%2C+Dorothea%3BBacharach%2C+Steve+L%3BUlisney%2C+Karen+L%3BFananapazir%2C+Lameh%3BHadi%2C+Mohiuddin%3BPlehn%2C+Jonathan+F&rft.aulast=Owens&rft.aufirst=David&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tnf Receptor-Associated Factor 2 (TRAF2) is an Important Adaptor in Activation of Nuclear Factor (NF-KB) and Activation Protein (AP-1) Pathways in Human B Cells T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39960211; 4104232 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Martins, Diana C AU - Zhang, Wen AU - Zhang, Xuan AU - He, Liusheng AU - Lipsky, Peter E AU - Grammer, Amrie C Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Cell activation KW - Lymphocytes B KW - Tumor necrosis factor KW - NF-^KB protein KW - TRAF2 protein KW - Adaptor proteins KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39960211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Tnf+Receptor-Associated+Factor+2+%28TRAF2%29+is+an+Important+Adaptor+in+Activation+of+Nuclear+Factor+%28NF-KB%29+and+Activation+Protein+%28AP-1%29+Pathways+in+Human+B+Cells&rft.au=Martins%2C+Diana+C%3BZhang%2C+Wen%3BZhang%2C+Xuan%3BHe%2C+Liusheng%3BLipsky%2C+Peter+E%3BGrammer%2C+Amrie+C&rft.aulast=Martins&rft.aufirst=Diana&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bone Density and Metabolism in Patients with NOMID after 12 Months of Treatment with the IL-1 Receptor-Antagonist Anakinra/kineretRG T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39944745; 4103101 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Canna, S AU - Gelabert, A AU - Jones, J AU - Dailey, N J AU - Kastner, D AU - Reynolds, J AU - Goldbach-Mansky, R Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Bone density KW - Metabolism KW - Interleukin 1 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39944745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Bone+Density+and+Metabolism+in+Patients+with+NOMID+after+12+Months+of+Treatment+with+the+IL-1+Receptor-Antagonist+Anakinra%2FkineretRG&rft.au=Canna%2C+S%3BGelabert%2C+A%3BJones%2C+J%3BDailey%2C+N+J%3BKastner%2C+D%3BReynolds%2C+J%3BGoldbach-Mansky%2C+R&rft.aulast=Canna&rft.aufirst=S&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impact of Rheumatoid Arthritis (RA) Core Set Measures on Rheumatologists Judgment of Disease Activity T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39941991; 4103343 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Aletaha, Daniel AU - Machold, Klaus P AU - Nell, Valerie P.K. AU - Smolen, Josef S Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Cores KW - Rheumatoid arthritis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39941991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Impact+of+Rheumatoid+Arthritis+%28RA%29+Core+Set+Measures+on+Rheumatologists+Judgment+of+Disease+Activity&rft.au=Aletaha%2C+Daniel%3BMachold%2C+Klaus+P%3BNell%2C+Valerie+P.K.%3BSmolen%2C+Josef+S&rft.aulast=Aletaha&rft.aufirst=Daniel&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Prevalence of Infarct and Non-Infarct as the Etiology in Impaired Left Ventricular Systolic Function in the Elderly: A Gadolinium Enhanced Cardiac MRI Study T2 - 2005 Scientific Sessions of the American Heart Association AN - 39908609; 4108648 JF - 2005 Scientific Sessions of the American Heart Association AU - Cao, Jie J AU - Sigurdsson, Sigurdur AU - Vincent, Pamela AU - Padmanabhan, Sriram AU - Holly, Jessica AU - Launer, Lenore AU - Aletras, Anthony H AU - Eiriksdottir, Gudny AU - Thorgeirsson, Gudmundur AU - Aspelund, Thor AU - Gudnason, Vilmundur AU - Harris, Tamara AU - Arai, Andrew E Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Gadolinium KW - Elderly KW - Etiology KW - Magnetic resonance imaging KW - Heart KW - Geriatrics KW - Aetiology KW - Circulatory system KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39908609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=The+Prevalence+of+Infarct+and+Non-Infarct+as+the+Etiology+in+Impaired+Left+Ventricular+Systolic+Function+in+the+Elderly%3A+A+Gadolinium+Enhanced+Cardiac+MRI+Study&rft.au=Cao%2C+Jie+J%3BSigurdsson%2C+Sigurdur%3BVincent%2C+Pamela%3BPadmanabhan%2C+Sriram%3BHolly%2C+Jessica%3BLauner%2C+Lenore%3BAletras%2C+Anthony+H%3BEiriksdottir%2C+Gudny%3BThorgeirsson%2C+Gudmundur%3BAspelund%2C+Thor%3BGudnason%2C+Vilmundur%3BHarris%2C+Tamara%3BArai%2C+Andrew+E&rft.aulast=Cao&rft.aufirst=Jie&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Heterogeneous Skeletal Muscle Perfusion Recovery after Stenting: Insight into Regional Ischemic Blood Flow Control T2 - 2005 Scientific Sessions of the American Heart Association AN - 39907826; 4107904 JF - 2005 Scientific Sessions of the American Heart Association AU - Aviles, Ronnier J AU - Thompson, Richard B AU - Ozturk, Cengizhan AU - Raval, Amish N AU - DeSilva, Ranil AU - Stine, Annette AU - Wright, Victor AU - Raman, Venkatesh K AU - Balaban, Robert S AU - Lederman, Robert J Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Blood circulation KW - Ischemia KW - Perfusion KW - Skeletal muscle KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39907826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Heterogeneous+Skeletal+Muscle+Perfusion+Recovery+after+Stenting%3A+Insight+into+Regional+Ischemic+Blood+Flow+Control&rft.au=Aviles%2C+Ronnier+J%3BThompson%2C+Richard+B%3BOzturk%2C+Cengizhan%3BRaval%2C+Amish+N%3BDeSilva%2C+Ranil%3BStine%2C+Annette%3BWright%2C+Victor%3BRaman%2C+Venkatesh+K%3BBalaban%2C+Robert+S%3BLederman%2C+Robert+J&rft.aulast=Aviles&rft.aufirst=Ronnier&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Contribution of Hepatic and Extrahepatic ABCA1 to Plasma HDL-C and ApoB-Containing Lipoprotein Cholesterol in Transgenic Mice T2 - 2005 Scientific Sessions of the American Heart Association AN - 39892224; 4110770 JF - 2005 Scientific Sessions of the American Heart Association AU - Liu, Lijuan AU - Joyce, Charles AU - Vaisman, Boris AU - Basso, Federica AU - Amar, Marcelo J A AU - Shamburek, Robert D AU - Santamarina-Fojo, Silvia Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Mice KW - Lipoproteins KW - Cholesterol KW - Liver KW - Transgenic mice KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39892224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Contribution+of+Hepatic+and+Extrahepatic+ABCA1+to+Plasma+HDL-C+and+ApoB-Containing+Lipoprotein+Cholesterol+in+Transgenic+Mice&rft.au=Liu%2C+Lijuan%3BJoyce%2C+Charles%3BVaisman%2C+Boris%3BBasso%2C+Federica%3BAmar%2C+Marcelo+J+A%3BShamburek%2C+Robert+D%3BSantamarina-Fojo%2C+Silvia&rft.aulast=Liu&rft.aufirst=Lijuan&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Simple and Rapid Quantification of Mechanical Dyssynchrony for Cardiac Resynchronization Therapy T2 - 2005 Scientific Sessions of the American Heart Association AN - 39885360; 4109192 JF - 2005 Scientific Sessions of the American Heart Association AU - Ashikaga, Hiroshi AU - Kellman, Peter AU - Mickelsen, Steven R AU - McVeigh, Elliot R Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Heart KW - Therapy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39885360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Simple+and+Rapid+Quantification+of+Mechanical+Dyssynchrony+for+Cardiac+Resynchronization+Therapy&rft.au=Ashikaga%2C+Hiroshi%3BKellman%2C+Peter%3BMickelsen%2C+Steven+R%3BMcVeigh%2C+Elliot+R&rft.aulast=Ashikaga&rft.aufirst=Hiroshi&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microalbuminuria and the Risk of Cardiovascular Events and All-Cause Mortality in the Elderly, the Cardiovascular Health Study T2 - 2005 Scientific Sessions of the American Heart Association AN - 39884722; 4108306 JF - 2005 Scientific Sessions of the American Heart Association AU - Cao, Jie J AU - Biggs, Mary L AU - Barzilay, Joshua AU - Konen, Joseph AU - Psaty, Bruce M AU - Kuller, Lewis AU - Bleyer, Anthony J AU - Olson, Jean AU - Wexler, Jason AU - Summerson, John AU - Cushman, Mary Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Elderly KW - Mortality KW - Geriatrics KW - Cardiovascular diseases KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39884722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Microalbuminuria+and+the+Risk+of+Cardiovascular+Events+and+All-Cause+Mortality+in+the+Elderly%2C+the+Cardiovascular+Health+Study&rft.au=Cao%2C+Jie+J%3BBiggs%2C+Mary+L%3BBarzilay%2C+Joshua%3BKonen%2C+Joseph%3BPsaty%2C+Bruce+M%3BKuller%2C+Lewis%3BBleyer%2C+Anthony+J%3BOlson%2C+Jean%3BWexler%2C+Jason%3BSummerson%2C+John%3BCushman%2C+Mary&rft.aulast=Cao&rft.aufirst=Jie&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An SLE-Associated Mutation in CD40 Alters Human B Cell Function T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39883841; 4104233 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Zhang, Wen AU - Fischer, Randy AU - He, Luisheng AU - Pisitkun, Prapaporn AU - Gaffney, P AU - Behrens, T AU - Lipsky, Peter E AU - Grammer, Amrie C Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Mutation KW - CD40 antigen KW - Lymphocytes B KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39883841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=An+SLE-Associated+Mutation+in+CD40+Alters+Human+B+Cell+Function&rft.au=Zhang%2C+Wen%3BFischer%2C+Randy%3BHe%2C+Luisheng%3BPisitkun%2C+Prapaporn%3BGaffney%2C+P%3BBehrens%2C+T%3BLipsky%2C+Peter+E%3BGrammer%2C+Amrie+C&rft.aulast=Zhang&rft.aufirst=Wen&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression, Phenotypic and Proteomic Profile of Ig-Secreting Plasma Cells in the Periphery of Patients with Active Sle T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39880237; 4104228 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Lugar, Patricia AU - Slota, Rebecca AU - Fischer, Randy AU - Phillips, Terry AU - Brescia, AnneMarie AU - Lipsky, Peter AU - Grammer, Amrie C Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Gene expression KW - Plasma cells KW - Proteomics KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39880237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Gene+Expression%2C+Phenotypic+and+Proteomic+Profile+of+Ig-Secreting+Plasma+Cells+in+the+Periphery+of+Patients+with+Active+Sle&rft.au=Lugar%2C+Patricia%3BSlota%2C+Rebecca%3BFischer%2C+Randy%3BPhillips%2C+Terry%3BBrescia%2C+AnneMarie%3BLipsky%2C+Peter%3BGrammer%2C+Amrie+C&rft.aulast=Lugar&rft.aufirst=Patricia&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Performance-Based Assessment of Functional Limitation and Muscle Endurance: Reliability of the Adult Myositis Assessment Tool T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39877001; 4103852 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Harris-Love, Michael AU - Joe, Galen AU - Abbett, Kristen AU - Koziol, Dee Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Muscles KW - Myositis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39877001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Performance-Based+Assessment+of+Functional+Limitation+and+Muscle+Endurance%3A+Reliability+of+the+Adult+Myositis+Assessment+Tool&rft.au=Harris-Love%2C+Michael%3BJoe%2C+Galen%3BAbbett%2C+Kristen%3BKoziol%2C+Dee&rft.aulast=Harris-Love&rft.aufirst=Michael&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Amplified Profiling of Platelet Transcriptome in Sickle Cell Disease Reveals Global Activation and Dysregulated Arginine Processing T2 - 2005 Scientific Sessions of the American Heart Association AN - 39876908; 4110543 JF - 2005 Scientific Sessions of the American Heart Association AU - Raghahavachari, Nalini AU - Villagra, Jose AU - Harris, Amy AU - Logun, Carolea AU - Xu, Xiuli AU - Munson, Peter AU - Kato, Gregory AU - Solomon, Michael A AU - Danner, Robert A AU - Gladwin, Mark T Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Platelets KW - Sickle cell disease KW - Arginine KW - Profiling KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39876908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Amplified+Profiling+of+Platelet+Transcriptome+in+Sickle+Cell+Disease+Reveals+Global+Activation+and+Dysregulated+Arginine+Processing&rft.au=Raghahavachari%2C+Nalini%3BVillagra%2C+Jose%3BHarris%2C+Amy%3BLogun%2C+Carolea%3BXu%2C+Xiuli%3BMunson%2C+Peter%3BKato%2C+Gregory%3BSolomon%2C+Michael+A%3BDanner%2C+Robert+A%3BGladwin%2C+Mark+T&rft.aulast=Raghahavachari&rft.aufirst=Nalini&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inducible Mitochondrial Uncoupling - An Endogenous Regulatory Mechanism Augmenting Tolerance to Cardiac Ischemia T2 - 2005 Scientific Sessions of the American Heart Association AN - 39875551; 4109711 JF - 2005 Scientific Sessions of the American Heart Association AU - McLeod, Christopher J AU - McCoy Jr, J Philip AU - Aziz, Abdulhameed AU - Sack, Michael N Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Ischemia KW - Mitochondria KW - Heart KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39875551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Inducible+Mitochondrial+Uncoupling+-+An+Endogenous+Regulatory+Mechanism+Augmenting+Tolerance+to+Cardiac+Ischemia&rft.au=McLeod%2C+Christopher+J%3BMcCoy+Jr%2C+J+Philip%3BAziz%2C+Abdulhameed%3BSack%2C+Michael+N&rft.aulast=McLeod&rft.aufirst=Christopher&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Specific Occupational Activities Associated with Functional Limitations in Patients with Long-Standing Ankylosing Spondylitis T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39875424; 4103603 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Ward, Michael M AU - Reveille, John D AU - Davis, John C AU - Weisman, Michael Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Ankylosing spondylitis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39875424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Specific+Occupational+Activities+Associated+with+Functional+Limitations+in+Patients+with+Long-Standing+Ankylosing+Spondylitis&rft.au=Ward%2C+Michael+M%3BReveille%2C+John+D%3BDavis%2C+John+C%3BWeisman%2C+Michael&rft.aulast=Ward&rft.aufirst=Michael&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Met66 Variant of the Functional Val66Met Polymorphism in the Brain-Derived Neurotrophic Factor Gene Confers Protection against Cognitive Dysfunction in Systemic Lupus Erythematosus (SLE) T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39869735; 4103569 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Lapteva, Larissa AU - Oroszi, Gabor AU - Davis, Elizabeth AU - Yarboro, Cheryl H AU - Lipsky, Peter E AU - Goldman, David AU - Hu, Xian-Zhang AU - Lipsky, Robert AU - Illei, Gabor G Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Systemic lupus erythematosus KW - Gene polymorphism KW - Brain-derived neurotrophic factor KW - Cognitive ability KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39869735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=The+Met66+Variant+of+the+Functional+Val66Met+Polymorphism+in+the+Brain-Derived+Neurotrophic+Factor+Gene+Confers+Protection+against+Cognitive+Dysfunction+in+Systemic+Lupus+Erythematosus+%28SLE%29&rft.au=Lapteva%2C+Larissa%3BOroszi%2C+Gabor%3BDavis%2C+Elizabeth%3BYarboro%2C+Cheryl+H%3BLipsky%2C+Peter+E%3BGoldman%2C+David%3BHu%2C+Xian-Zhang%3BLipsky%2C+Robert%3BIllei%2C+Gabor+G&rft.aulast=Lapteva&rft.aufirst=Larissa&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Impact of In Vivo Anti IL-6 Receptor Blockade on Circulating T and B Cell Subsets in Patients with Systemic Lupus Erythematosus T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39869133; 4103159 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Shirota, Yuko AU - Yarboro, Cheryl AU - Sims, Gary AU - Fritsch, Ruth AU - Ettinger, Rachel AU - Valencia, Xavier AU - Fischer, Randy AU - Grammer, Amrie AU - Pham, Tuyet-Hang AU - Lipsky, Peter E AU - Illei, Gabor G Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Lymphocytes B KW - Systemic lupus erythematosus KW - Interleukin 6 receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39869133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=The+Impact+of+In+Vivo+Anti+IL-6+Receptor+Blockade+on+Circulating+T+and+B+Cell+Subsets+in+Patients+with+Systemic+Lupus+Erythematosus&rft.au=Shirota%2C+Yuko%3BYarboro%2C+Cheryl%3BSims%2C+Gary%3BFritsch%2C+Ruth%3BEttinger%2C+Rachel%3BValencia%2C+Xavier%3BFischer%2C+Randy%3BGrammer%2C+Amrie%3BPham%2C+Tuyet-Hang%3BLipsky%2C+Peter+E%3BIllei%2C+Gabor+G&rft.aulast=Shirota&rft.aufirst=Yuko&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Contribution of Nitric Oxide to Endothelial Progenitor Cell Mobilization, Survival and Differentiation Potential in Patients with Coronary Artery Disease Undergoing Cardiac Rehabilitation T2 - 2005 Scientific Sessions of the American Heart Association AN - 39865050; 4110264 JF - 2005 Scientific Sessions of the American Heart Association AU - Rodrigo, Maria E AU - Benjamin, Moshe AU - Carlow, Andrea AU - Annavajjhala, Vidhya AU - Dejam, Andre AU - Paul, Jonathan D AU - Powell, Tiffany M AU - Thompson, Michael AU - McCoy, J Philip AU - Zalos, Gloria AU - Murphy, Mandy AU - Hill, Jonathan M AU - Gladwin, Mark AU - Orlic, Donald AU - Cannon III, Richard O Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Nitric oxide KW - Heart diseases KW - Coronary heart disease KW - Differentiation KW - Rehabilitation KW - Cell survival KW - Stem cells KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39865050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Contribution+of+Nitric+Oxide+to+Endothelial+Progenitor+Cell+Mobilization%2C+Survival+and+Differentiation+Potential+in+Patients+with+Coronary+Artery+Disease+Undergoing+Cardiac+Rehabilitation&rft.au=Rodrigo%2C+Maria+E%3BBenjamin%2C+Moshe%3BCarlow%2C+Andrea%3BAnnavajjhala%2C+Vidhya%3BDejam%2C+Andre%3BPaul%2C+Jonathan+D%3BPowell%2C+Tiffany+M%3BThompson%2C+Michael%3BMcCoy%2C+J+Philip%3BZalos%2C+Gloria%3BMurphy%2C+Mandy%3BHill%2C+Jonathan+M%3BGladwin%2C+Mark%3BOrlic%2C+Donald%3BCannon+III%2C+Richard+O&rft.aulast=Rodrigo&rft.aufirst=Maria&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - S-Nitrosylation of the L-type Ca@@u2+@ Channel is Involved in Cardioprotection in Female Hearts T2 - 2005 Scientific Sessions of the American Heart Association AN - 39863819; 4107206 JF - 2005 Scientific Sessions of the American Heart Association AU - Sun, Junhui AU - Picht, Eckard AU - Bers, Donald AU - Steenbergen, Charles AU - Murphy, Elizabeth Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Calcium channels (L-type) KW - Heart KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39863819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=S-Nitrosylation+of+the+L-type+Ca%40%40u2%2B%40+Channel+is+Involved+in+Cardioprotection+in+Female+Hearts&rft.au=Sun%2C+Junhui%3BPicht%2C+Eckard%3BBers%2C+Donald%3BSteenbergen%2C+Charles%3BMurphy%2C+Elizabeth&rft.aulast=Sun&rft.aufirst=Junhui&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Accuracy of Glomerular Filtration Rate (GFR) Prediction Equations in Patients with Immune-Mediated Glomerulonephritides (GN) T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39860142; 4104083 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Illei, Gabor G AU - Jacobs, Geneva AU - Austin, Howard AU - Ward, Michael Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Filtration KW - Glomerular filtration rate KW - Mathematical models KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39860142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Accuracy+of+Glomerular+Filtration+Rate+%28GFR%29+Prediction+Equations+in+Patients+with+Immune-Mediated+Glomerulonephritides+%28GN%29&rft.au=Illei%2C+Gabor+G%3BJacobs%2C+Geneva%3BAustin%2C+Howard%3BWard%2C+Michael&rft.aulast=Illei&rft.aufirst=Gabor&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Trends in Diabetes as a Cardiovascular Disease Risk Factor: the Framingham Heart Study T2 - 2005 Scientific Sessions of the American Heart Association AN - 39857965; 4108325 JF - 2005 Scientific Sessions of the American Heart Association AU - Fox, Caroline S AU - Coady, Sean AU - Sorlie, Paul D AU - D'Agostino Sr, Ralph B AU - Vasan, Ramachandran S AU - Meigs, James B AU - Levy, Daniel AU - Savage, Peter J Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Cardiovascular diseases KW - Risk factors KW - Diabetes mellitus KW - Heart KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39857965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Trends+in+Diabetes+as+a+Cardiovascular+Disease+Risk+Factor%3A+the+Framingham+Heart+Study&rft.au=Fox%2C+Caroline+S%3BCoady%2C+Sean%3BSorlie%2C+Paul+D%3BD%27Agostino+Sr%2C+Ralph+B%3BVasan%2C+Ramachandran+S%3BMeigs%2C+James+B%3BLevy%2C+Daniel%3BSavage%2C+Peter+J&rft.aulast=Fox&rft.aufirst=Caroline&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Myeloperoxidase (MPO) Modulates Risk for Developing Congestive Heart Failure (CHF) T2 - 2005 Scientific Sessions of the American Heart Association AN - 39852900; 4109162 JF - 2005 Scientific Sessions of the American Heart Association AU - Aviles, Ronnier J AU - Brennan, Marie-Luise AU - Mann, Shirley AU - Tracy, Russell P AU - Psaty, Bruce M AU - Hazen, Stanley L Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Congestive heart failure KW - Risk factors KW - Peroxidase KW - Heart KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39852900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Myeloperoxidase+%28MPO%29+Modulates+Risk+for+Developing+Congestive+Heart+Failure+%28CHF%29&rft.au=Aviles%2C+Ronnier+J%3BBrennan%2C+Marie-Luise%3BMann%2C+Shirley%3BTracy%2C+Russell+P%3BPsaty%2C+Bruce+M%3BHazen%2C+Stanley+L&rft.aulast=Aviles&rft.aufirst=Ronnier&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ABCG1-Modifed Plasma Membrane Lipid Domains Mediate Cellular Cholesterol Efflux to HDL T2 - 2005 Scientific Sessions of the American Heart Association AN - 39850818; 4110632 JF - 2005 Scientific Sessions of the American Heart Association AU - Neufeld, Edward B AU - O'Brien, Katherine G AU - Demosky Jr, Stephen J AU - Stonik, John A AU - Sabol, Steven L AU - Malide, Daniela AU - Combs, Christian A AU - Remaley, Alan T AU - Santamarina-Fojo, Silvia AU - Brewer Jr, H Bryan Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Lipid rafts KW - Plasma membranes KW - Cholesterol KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39850818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=ABCG1-Modifed+Plasma+Membrane+Lipid+Domains+Mediate+Cellular+Cholesterol+Efflux+to+HDL&rft.au=Neufeld%2C+Edward+B%3BO%27Brien%2C+Katherine+G%3BDemosky+Jr%2C+Stephen+J%3BStonik%2C+John+A%3BSabol%2C+Steven+L%3BMalide%2C+Daniela%3BCombs%2C+Christian+A%3BRemaley%2C+Alan+T%3BSantamarina-Fojo%2C+Silvia%3BBrewer+Jr%2C+H+Bryan&rft.aulast=Neufeld&rft.aufirst=Edward&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Validity of the Myositis Disease Activity Assessment Tool (MDAAT) for Assessing Extra-Muscular Disease Activity in Adult and Juvenile Idiopathic Inflammatory Myopathies (IIM) T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39848655; 4103891 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Rider, Lisa AU - Villalba, Maria AU - Adams, Elizabeth AU - Joe, Galen AU - Harris-Love, Michael AU - Hill, Suvimol AU - James-Newton, Laura AU - Hicks, Jeanne AU - Plotz, Paul AU - Lachenbruch, Peter AU - Miller, Frederick Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Myositis KW - Inflammation KW - Myopathy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39848655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Validity+of+the+Myositis+Disease+Activity+Assessment+Tool+%28MDAAT%29+for+Assessing+Extra-Muscular+Disease+Activity+in+Adult+and+Juvenile+Idiopathic+Inflammatory+Myopathies+%28IIM%29&rft.au=Rider%2C+Lisa%3BVillalba%2C+Maria%3BAdams%2C+Elizabeth%3BJoe%2C+Galen%3BHarris-Love%2C+Michael%3BHill%2C+Suvimol%3BJames-Newton%2C+Laura%3BHicks%2C+Jeanne%3BPlotz%2C+Paul%3BLachenbruch%2C+Peter%3BMiller%2C+Frederick&rft.aulast=Rider&rft.aufirst=Lisa&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Treatment of 4 Patients with Cryopyrin-Associated Periodic Syndromes with the Long-Acting Il-1 Inhibitor Il-1 Trap T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39846580; 4102932 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Canna, S AU - Gelabert, A AU - Aksentijevich, I AU - Mellis, S AU - Radin, A AU - Papadopoulos, J AU - Barham, B AU - Wilson, M AU - Hawkins, P AU - Kastner, D AU - Goldbach-Mansky, R Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Interleukin 1 KW - Inhibitors KW - Symptoms KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39846580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Treatment+of+4+Patients+with+Cryopyrin-Associated+Periodic+Syndromes+with+the+Long-Acting+Il-1+Inhibitor+Il-1+Trap&rft.au=Canna%2C+S%3BGelabert%2C+A%3BAksentijevich%2C+I%3BMellis%2C+S%3BRadin%2C+A%3BPapadopoulos%2C+J%3BBarham%2C+B%3BWilson%2C+M%3BHawkins%2C+P%3BKastner%2C+D%3BGoldbach-Mansky%2C+R&rft.aulast=Canna&rft.aufirst=S&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Seasonal Birth Patterns in Subgroups of Myositis Suggest a Role for Perinatal Environmental Factors in Etiology T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39845595; 4103649 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Vegosen, Leora AU - Weinberg, Clarice AU - O'Hanlon, Terrance AU - Targoff, Ira AU - Koneru, Bhanu AU - Mamyrova, Gulnara AU - Miller, Frederick AU - Rider, Lisa Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Seasonal variations KW - Etiology KW - Sulfur dioxide KW - Myositis KW - Birth KW - Environmental factors KW - Aetiology KW - Parturition KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39845595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Seasonal+Birth+Patterns+in+Subgroups+of+Myositis+Suggest+a+Role+for+Perinatal+Environmental+Factors+in+Etiology&rft.au=Vegosen%2C+Leora%3BWeinberg%2C+Clarice%3BO%27Hanlon%2C+Terrance%3BTargoff%2C+Ira%3BKoneru%2C+Bhanu%3BMamyrova%2C+Gulnara%3BMiller%2C+Frederick%3BRider%2C+Lisa&rft.aulast=Vegosen&rft.aufirst=Leora&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Multiple Serum Cytokines and Chemokines in SLE Patients Demonstrates that They Highly Correlate to Each Other and Fails to Identify a Principal Effector Molecule T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39844877; 4103585 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Illei, Gabor G AU - Phillips, Terry M AU - Yarboro, Cheryl AU - Pham, Tuyet-Hang AU - Sun, Hong-Wei AU - Lipsky, Peter E Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Cytokines KW - Chemokines KW - Serum KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39844877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Analysis+of+Multiple+Serum+Cytokines+and+Chemokines+in+SLE+Patients+Demonstrates+that+They+Highly+Correlate+to+Each+Other+and+Fails+to+Identify+a+Principal+Effector+Molecule&rft.au=Illei%2C+Gabor+G%3BPhillips%2C+Terry+M%3BYarboro%2C+Cheryl%3BPham%2C+Tuyet-Hang%3BSun%2C+Hong-Wei%3BLipsky%2C+Peter+E&rft.aulast=Illei&rft.aufirst=Gabor&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Defective Suppressor Function of CD4+CD25hi T Regulatory Cells in Active SLE T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39842472; 4104666 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Valencia, Xavier AU - Vogt, Samantha L AU - Simone, James AU - Yarboro, Cheryl AU - Illei, Gabor AU - Lipsky, Peter E Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Lymphocytes T KW - Immunoregulation KW - Suppressors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39842472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Defective+Suppressor+Function+of+CD4%2BCD25hi+T+Regulatory+Cells+in+Active+SLE&rft.au=Valencia%2C+Xavier%3BVogt%2C+Samantha+L%3BSimone%2C+James%3BYarboro%2C+Cheryl%3BIllei%2C+Gabor%3BLipsky%2C+Peter+E&rft.aulast=Valencia&rft.aufirst=Xavier&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Myocardial Iron Is Not Significantly Abnormal in Patients with Minimally Symptomatic Hereditary Hemochromatosis T2 - 2005 Scientific Sessions of the American Heart Association AN - 39840634; 4108717 JF - 2005 Scientific Sessions of the American Heart Association AU - Padmanabhan, Sriram AU - Shizukuda, Yukitaka AU - Aletras, Anthony H AU - Mordini, Federico AU - Ingkanisorn, W Patricia AU - Cao, Jie AU - Tripodi, Dottie AU - Rosing, Douglas R AU - Bolan, Charles D AU - Leitman, Susan F AU - Arai, Andrew E Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Iron KW - Hemochromatosis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39840634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Myocardial+Iron+Is+Not+Significantly+Abnormal+in+Patients+with+Minimally+Symptomatic+Hereditary+Hemochromatosis&rft.au=Padmanabhan%2C+Sriram%3BShizukuda%2C+Yukitaka%3BAletras%2C+Anthony+H%3BMordini%2C+Federico%3BIngkanisorn%2C+W+Patricia%3BCao%2C+Jie%3BTripodi%2C+Dottie%3BRosing%2C+Douglas+R%3BBolan%2C+Charles+D%3BLeitman%2C+Susan+F%3BArai%2C+Andrew+E&rft.aulast=Padmanabhan&rft.aufirst=Sriram&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Patients' Judgments of Improvement in Rheumatoid Arthritis with ACR and EULAR Response Criteria T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39840550; 4103351 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Ward, Michael M AU - Guthrie, Lori C Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Rheumatoid arthritis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39840550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Comparison+of+Patients%27+Judgments+of+Improvement+in+Rheumatoid+Arthritis+with+ACR+and+EULAR+Response+Criteria&rft.au=Ward%2C+Michael+M%3BGuthrie%2C+Lori+C&rft.aulast=Ward&rft.aufirst=Michael&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Changes in Selected Proteins Associated with Osteoarthritis Development in the Baltimore Longitudinal Study of Aging (BLSA) T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39839031; 4103180 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Ling, Shari M AU - Patel, Dhavalkumar AU - Zhan, Ming AU - Taub, Dennis AU - Muller, Denis AU - Bathon, Joan AU - Hochberg, Marc AU - Abernethy, Darrell AU - Metter, E AU - Ferrucci, Luigi Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - USA, Maryland, Baltimore KW - Aging KW - Osteoarthritis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39839031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Changes+in+Selected+Proteins+Associated+with+Osteoarthritis+Development+in+the+Baltimore+Longitudinal+Study+of+Aging+%28BLSA%29&rft.au=Ling%2C+Shari+M%3BPatel%2C+Dhavalkumar%3BZhan%2C+Ming%3BTaub%2C+Dennis%3BMuller%2C+Denis%3BBathon%2C+Joan%3BHochberg%2C+Marc%3BAbernethy%2C+Darrell%3BMetter%2C+E%3BFerrucci%2C+Luigi&rft.aulast=Ling&rft.aufirst=Shari&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Characteristics of Children with Neonatal Onset Multisystem Inflammatory Disease (NOMID) T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39835976; 4104861 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Canna, Scott AU - Paul, Scott M AU - Hildenbrand, Hanna AU - Jain, Mina AU - Smith, Michaele R AU - Comis, Leora AU - Goldbach-Mansky, Raphaela Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Children KW - Neonates KW - Inflammatory diseases KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39835976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Functional+Characteristics+of+Children+with+Neonatal+Onset+Multisystem+Inflammatory+Disease+%28NOMID%29&rft.au=Canna%2C+Scott%3BPaul%2C+Scott+M%3BHildenbrand%2C+Hanna%3BJain%2C+Mina%3BSmith%2C+Michaele+R%3BComis%2C+Leora%3BGoldbach-Mansky%2C+Raphaela&rft.aulast=Canna&rft.aufirst=Scott&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transcript Profiling of Peripheral Blood Circulating Endothelial Cells T2 - 2005 Scientific Sessions of the American Heart Association AN - 39827602; 4107574 JF - 2005 Scientific Sessions of the American Heart Association AU - Raghavachari, Nalini AU - Khan, Sameena S AU - Elshal, Mohamed AU - Barb, Jennifer AU - Logun, Carolea AU - Munson, Peter J AU - Gladwin, Mark T AU - McCoy, J Philip AU - Danner, Robert L AU - Solomon, Michael A Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Peripheral blood KW - Blood circulation KW - Transcription KW - Endothelial cells KW - Profiling KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39827602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Transcript+Profiling+of+Peripheral+Blood+Circulating+Endothelial+Cells&rft.au=Raghavachari%2C+Nalini%3BKhan%2C+Sameena+S%3BElshal%2C+Mohamed%3BBarb%2C+Jennifer%3BLogun%2C+Carolea%3BMunson%2C+Peter+J%3BGladwin%2C+Mark+T%3BMcCoy%2C+J+Philip%3BDanner%2C+Robert+L%3BSolomon%2C+Michael+A&rft.aulast=Raghavachari&rft.aufirst=Nalini&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ghrelin Improves Endothelial Function in Patients with Metabolic Syndrome T2 - 2005 Scientific Sessions of the American Heart Association AN - 39825983; 4108032 JF - 2005 Scientific Sessions of the American Heart Association AU - Iantorno, Micaela AU - Schinzari, Francesca AU - Tesauro, Manfredi AU - Rizza, Stefano AU - Melina, Domenico AU - Lauro, Davide AU - Cardillo, Carmine Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Ghrelin KW - Symptoms KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39825983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Ghrelin+Improves+Endothelial+Function+in+Patients+with+Metabolic+Syndrome&rft.au=Iantorno%2C+Micaela%3BSchinzari%2C+Francesca%3BTesauro%2C+Manfredi%3BRizza%2C+Stefano%3BMelina%2C+Domenico%3BLauro%2C+Davide%3BCardillo%2C+Carmine&rft.aulast=Iantorno&rft.aufirst=Micaela&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cardiac-Specific Ablation of the Na@@u+@/Ca@@u2+@ Exchanger Confers Protection against Ischemia-Reperfusion Injury T2 - 2005 Scientific Sessions of the American Heart Association AN - 39811868; 4109747 JF - 2005 Scientific Sessions of the American Heart Association AU - Imahashi, Kenichi AU - Steenbergen, Charles AU - Philipson, Kenneth D AU - Murphy, Elizabeth Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Injuries KW - Na@u+/Ca@@u2+@-exchanging ATPase KW - Calcium KW - Ablation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39811868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Cardiac-Specific+Ablation+of+the+Na%40%40u%2B%40%2FCa%40%40u2%2B%40+Exchanger+Confers+Protection+against+Ischemia-Reperfusion+Injury&rft.au=Imahashi%2C+Kenichi%3BSteenbergen%2C+Charles%3BPhilipson%2C+Kenneth+D%3BMurphy%2C+Elizabeth&rft.aulast=Imahashi&rft.aufirst=Kenichi&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DRB1*0301 and the Second Hypervariable Region DRB1 Motif, @@u70@QKRGR@@u74@ are HLA Risk Factors for Dermatomyositis (DM) in African-American (AA) Patients T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39804491; 4103872 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Mamyrova, Gulnara AU - O'Hanlon, Terrance AU - Carrick, Danielle AU - Malley, James AU - Miller, Frederick AU - Rider, Lisa Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Africa KW - Histocompatibility antigen HLA KW - Dermatomyositis KW - Risk factors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39804491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=DRB1*0301+and+the+Second+Hypervariable+Region+DRB1+Motif%2C+%40%40u70%40QKRGR%40%40u74%40+are+HLA+Risk+Factors+for+Dermatomyositis+%28DM%29+in+African-American+%28AA%29+Patients&rft.au=Mamyrova%2C+Gulnara%3BO%27Hanlon%2C+Terrance%3BCarrick%2C+Danielle%3BMalley%2C+James%3BMiller%2C+Frederick%3BRider%2C+Lisa&rft.aulast=Mamyrova&rft.aufirst=Gulnara&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relative Importance of Immunogenetic Risk and Protective Factors for the Development of Juvenile Dermatomyositis (JDM) in European American (EA) Patients T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39801202; 4103873 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Mamyrova, Gulnara AU - Carrick, Danielle AU - O'Hanlon, Terrance AU - Malley, James AU - Reed, Ann AU - Sherry, David AU - Wallace, Carol AU - James-Newton, Laura AU - Zemel, Lawrence AU - Perez, Maria AU - Lindsley, Carol AU - Miller, Frederick AU - Rider, Lisa Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Immunogenetics KW - Dermatomyositis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39801202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Relative+Importance+of+Immunogenetic+Risk+and+Protective+Factors+for+the+Development+of+Juvenile+Dermatomyositis+%28JDM%29+in+European+American+%28EA%29+Patients&rft.au=Mamyrova%2C+Gulnara%3BCarrick%2C+Danielle%3BO%27Hanlon%2C+Terrance%3BMalley%2C+James%3BReed%2C+Ann%3BSherry%2C+David%3BWallace%2C+Carol%3BJames-Newton%2C+Laura%3BZemel%2C+Lawrence%3BPerez%2C+Maria%3BLindsley%2C+Carol%3BMiller%2C+Frederick%3BRider%2C+Lisa&rft.aulast=Mamyrova&rft.aufirst=Gulnara&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Outcomes of Treatment of Neonatal Onset Multisystem Inflammatory Disease (NOMID) with Anakinra: Preliminary Results T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39798493; 4104439 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Paul, Scott M AU - Hildenbrand, Hanna AU - Jain, Mina AU - Smith, Michaele R AU - Canna, Scott AU - Comis, Leora AU - Wiggs, Edith AU - Goldbach-Mansky, Raphaela Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Neonates KW - Inflammatory diseases KW - Disease control KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39798493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Functional+Outcomes+of+Treatment+of+Neonatal+Onset+Multisystem+Inflammatory+Disease+%28NOMID%29+with+Anakinra%3A+Preliminary+Results&rft.au=Paul%2C+Scott+M%3BHildenbrand%2C+Hanna%3BJain%2C+Mina%3BSmith%2C+Michaele+R%3BCanna%2C+Scott%3BComis%2C+Leora%3BWiggs%2C+Edith%3BGoldbach-Mansky%2C+Raphaela&rft.aulast=Paul&rft.aufirst=Scott&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional and Phenotypic Characterization of Anergic B Cells Circulating in the Periphery of Patients with Systemic Lupus Erythematosus T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39798303; 4103583 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Fischer, Randy T AU - Slota, Rebecca AU - Longo, Nancy AU - Lugar, Patricia AU - Sohn, Hae Won AU - Illei, Gabor AU - Phillips, Terry AU - Lipsky, Peter AU - Grammer, Amrie Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Lymphocytes B KW - Systemic lupus erythematosus KW - Anergy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39798303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Functional+and+Phenotypic+Characterization+of+Anergic+B+Cells+Circulating+in+the+Periphery+of+Patients+with+Systemic+Lupus+Erythematosus&rft.au=Fischer%2C+Randy+T%3BSlota%2C+Rebecca%3BLongo%2C+Nancy%3BLugar%2C+Patricia%3BSohn%2C+Hae+Won%3BIllei%2C+Gabor%3BPhillips%2C+Terry%3BLipsky%2C+Peter%3BGrammer%2C+Amrie&rft.aulast=Fischer&rft.aufirst=Randy&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activation of CaMKII at Mitochondria Triggers Apoptotic Cardiomyocyte Death T2 - 2005 Scientific Sessions of the American Heart Association AN - 39782301; 4109821 JF - 2005 Scientific Sessions of the American Heart Association AU - Zhu, Weizhong AU - yang, Dongmei AU - Crow, Mike T AU - Xiao, Rui-Ping Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Mortality KW - Apoptosis KW - Cardiomyocytes KW - Mitochondria KW - Ca@@u2+@/calmodulin-dependent protein kinase II KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39782301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Activation+of+CaMKII+at+Mitochondria+Triggers+Apoptotic+Cardiomyocyte+Death&rft.au=Zhu%2C+Weizhong%3Byang%2C+Dongmei%3BCrow%2C+Mike+T%3BXiao%2C+Rui-Ping&rft.aulast=Zhu&rft.aufirst=Weizhong&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Advancing Environmental Toxicogenomics. T2 - 26th Annual Meeting of the Society of Environmental Toxicology and Chemistry AN - 39721616; 4024402 DE: JF - 26th Annual Meeting of the Society of Environmental Toxicology and Chemistry AU - Waters, M Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39721616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+Society+of+Environmental+Toxicology+and+Chemistry&rft.atitle=Advancing+Environmental+Toxicogenomics.&rft.au=Waters%2C+M&rft.aulast=Waters&rft.aufirst=M&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+Society+of+Environmental+Toxicology+and+Chemistry&rft.issn=&rft_id=info:doi/ L2 - http://abstracts.co.allenpress.com/pweb/setac2005/program/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Brainstem Immunoreactivity Response to Chronic Laryngeal Inflammation in the Rat T2 - 35th Annual Meeting of the Society for Neuroscience AN - 40010434; 4132688 JF - 35th Annual Meeting of the Society for Neuroscience AU - Simonyan, K AU - Buckholdt, K AU - Ludlow, C L Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Immunoreactivity KW - Inflammation KW - Brain stem KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40010434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Brainstem+Immunoreactivity+Response+to+Chronic+Laryngeal+Inflammation+in+the+Rat&rft.au=Simonyan%2C+K%3BBuckholdt%2C+K%3BLudlow%2C+C+L&rft.aulast=Simonyan&rft.aufirst=K&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Offspring of VIP/PHI - Deficient Mice Exhibit Developmental Delays T2 - 35th Annual Meeting of the Society for Neuroscience AN - 40003083; 4128515 JF - 35th Annual Meeting of the Society for Neuroscience AU - Cuasay, K AU - May, V AU - Waschek, J A AU - Hill, J M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Offspring KW - Mice KW - Progeny KW - Vasoactive intestinal peptide KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40003083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Offspring+of+VIP%2FPHI+-+Deficient+Mice+Exhibit+Developmental+Delays&rft.au=Cuasay%2C+K%3BMay%2C+V%3BWaschek%2C+J+A%3BHill%2C+J+M&rft.aulast=Cuasay&rft.aufirst=K&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Human Corticospinal Input - output Characteristics Related to Motor Learning and PAS Intervention T2 - 35th Annual Meeting of the Society for Neuroscience AN - 40000535; 4129493 JF - 35th Annual Meeting of the Society for Neuroscience AU - Meunier, S O AU - Russmann, H AU - Hallett, M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Motor skill learning KW - Pyramidal tracts KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40000535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Comparison+of+Human+Corticospinal+Input+-+output+Characteristics+Related+to+Motor+Learning+and+PAS+Intervention&rft.au=Meunier%2C+S+O%3BRussmann%2C+H%3BHallett%2C+M&rft.aulast=Meunier&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of the Hereditary Spastic Paraplegia 3A ( SPG3A ) Protein Atlastin - 1 and Related Family Members T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39998942; 4126440 JF - 35th Annual Meeting of the Society for Neuroscience AU - Soderblom, C AU - Zhu, P AU - Stadler, J AU - Blackstone, C D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Spastic paraplegia KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39998942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Characterization+of+the+Hereditary+Spastic+Paraplegia+3A+%28+SPG3A+%29+Protein+Atlastin+-+1+and+Related+Family+Members&rft.au=Soderblom%2C+C%3BZhu%2C+P%3BStadler%2C+J%3BBlackstone%2C+C+D&rft.aulast=Soderblom&rft.aufirst=C&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distinct NMDA Receptor Subtypes at ON and OFF Inputs to Retinal Ganglion Cells T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39995709; 4127269 JF - 35th Annual Meeting of the Society for Neuroscience AU - Kalbaugh, T L AU - Diamond, J S Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Retinal ganglion cells KW - Glutamic acid receptors KW - N-Methyl-D-aspartic acid receptors KW - Ganglia KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39995709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Distinct+NMDA+Receptor+Subtypes+at+ON+and+OFF+Inputs+to+Retinal+Ganglion+Cells&rft.au=Kalbaugh%2C+T+L%3BDiamond%2C+J+S&rft.aulast=Kalbaugh&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Membrane - Targeting of Phosducin or Phosducin Like - Protein Occludes Voltage - Dependent Inhibition of N - Type Calcium Channels in Rat Superior Cervical Ganglia Neurons T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39995516; 4127253 JF - 35th Annual Meeting of the Society for Neuroscience AU - Partridge, J G AU - Ikeda, S R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Membranes KW - Phosducin KW - Calcium channels KW - Ganglia KW - Calcium channels (voltage-gated) KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39995516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Membrane+-+Targeting+of+Phosducin+or+Phosducin+Like+-+Protein+Occludes+Voltage+-+Dependent+Inhibition+of+N+-+Type+Calcium+Channels+in+Rat+Superior+Cervical+Ganglia+Neurons&rft.au=Partridge%2C+J+G%3BIkeda%2C+S+R&rft.aulast=Partridge&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Isolation and Characterization of an Enriched Preparation of Oligodendrocyte Progenitor Cell Membranes from Rat Cortex T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39993310; 4134345 JF - 35th Annual Meeting of the Society for Neuroscience AU - Weerth, S H AU - Hauser, J AU - Russell, J T Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Cell membranes KW - Glial stem cells KW - Cortex KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39993310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Isolation+and+Characterization+of+an+Enriched+Preparation+of+Oligodendrocyte+Progenitor+Cell+Membranes+from+Rat+Cortex&rft.au=Weerth%2C+S+H%3BHauser%2C+J%3BRussell%2C+J+T&rft.aulast=Weerth&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Social Experience Facilitates Aggression in Mice Lacking a Functional Vasopressin 1b Receptor Gene T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39991386; 4121039 JF - 35th Annual Meeting of the Society for Neuroscience AU - Caldwell, H K AU - Young, W S AU - Wersinger, S R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Mice KW - Aggression KW - Vasopressin KW - Aggressive behaviour KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39991386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Social+Experience+Facilitates+Aggression+in+Mice+Lacking+a+Functional+Vasopressin+1b+Receptor+Gene&rft.au=Caldwell%2C+H+K%3BYoung%2C+W+S%3BWersinger%2C+S+R&rft.aulast=Caldwell&rft.aufirst=H&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuronal Avalanche Dynamics are Independent of Initiating Event Size and Maintain Event Size Memory T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39988805; 4130851 JF - 35th Annual Meeting of the Society for Neuroscience AU - Thiagarajan, T C AU - Plenz, D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Avalanches KW - Memory KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39988805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neuronal+Avalanche+Dynamics+are+Independent+of+Initiating+Event+Size+and+Maintain+Event+Size+Memory&rft.au=Thiagarajan%2C+T+C%3BPlenz%2C+D&rft.aulast=Thiagarajan&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PICK1 is Required for Presynaptic Mossy Fiber - - CA3 Interneuron LTD T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39986171; 4125571 JF - 35th Annual Meeting of the Society for Neuroscience AU - Pelkey, K A AU - Racca, C AU - Takamiya, K AU - Xia, J AU - Huganir, R L AU - McBain, C J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Fibers KW - Long-term depression KW - Interneurons KW - Mossy fibers KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39986171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=PICK1+is+Required+for+Presynaptic+Mossy+Fiber+-+-+CA3+Interneuron+LTD&rft.au=Pelkey%2C+K+A%3BRacca%2C+C%3BTakamiya%2C+K%3BXia%2C+J%3BHuganir%2C+R+L%3BMcBain%2C+C+J&rft.aulast=Pelkey&rft.aufirst=K&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activity - Related Redistribution of Presynaptic Proteins at the Active Zone T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39985713; 4118968 JF - 35th Annual Meeting of the Society for Neuroscience AU - Tao-Cheng, J H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Proteins KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39985713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Activity+-+Related+Redistribution+of+Presynaptic+Proteins+at+the+Active+Zone&rft.au=Tao-Cheng%2C+J+H&rft.aulast=Tao-Cheng&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Cellular Mechanisms for Multiple Time - Scale Adaptation in Cerebellum T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39983780; 4120013 JF - 35th Annual Meeting of the Society for Neuroscience AU - Hong, S Y AU - Optican, L M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Adaptations KW - Cerebellum KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39983780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=New+Cellular+Mechanisms+for+Multiple+Time+-+Scale+Adaptation+in+Cerebellum&rft.au=Hong%2C+S+Y%3BOptican%2C+L+M&rft.aulast=Hong&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Unique Execution of NO - Mediated Toxicity within Naive and NGF - Differentiated PC12 Cells T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39939662; 4134945 JF - 35th Annual Meeting of the Society for Neuroscience AU - Brynczka, C AU - Merrick, B Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Toxicity KW - Pheochromocytoma cells KW - Nerve growth factor KW - Nitric oxide KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39939662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Unique+Execution+of+NO+-+Mediated+Toxicity+within+Naive+and+NGF+-+Differentiated+PC12+Cells&rft.au=Brynczka%2C+C%3BMerrick%2C+B&rft.aulast=Brynczka&rft.aufirst=C&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Self - Renewal of Rat Neural Stem Cells at the Beginning of Cortical Neurogenesis Does Not Require the Contribution of Endogenous Endothelial Cells T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39934827; 4132115 JF - 35th Annual Meeting of the Society for Neuroscience AU - Maric, D AU - Chang, Y H AU - Barker, J L Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Neurogenesis KW - Endothelial cells KW - Neural stem cells KW - Self KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39934827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Self+-+Renewal+of+Rat+Neural+Stem+Cells+at+the+Beginning+of+Cortical+Neurogenesis+Does+Not+Require+the+Contribution+of+Endogenous+Endothelial+Cells&rft.au=Maric%2C+D%3BChang%2C+Y+H%3BBarker%2C+J+L&rft.aulast=Maric&rft.aufirst=D&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enhanced Slow Oscillations in Neuronal Activity of Basal Ganglia Output Nuclei after Dopamine Cell Lesion in Urethane Anesthetized Rats: Exploring Effects on Ventrolateral Thalamus and Motor Cortex T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39934800; 4124504 JF - 35th Annual Meeting of the Society for Neuroscience AU - Parr-Brownlie, L C AU - Bergstrom, D A AU - Itoga, C A AU - Hu, D. AU - Smith, C.P.S. AU - Walters, J R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Carbamate compounds KW - Lesions KW - Rats KW - Oscillations KW - Basal ganglia KW - Urethane KW - Cortex (motor) KW - Thalamus KW - Dopamine KW - Ganglia KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39934800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Enhanced+Slow+Oscillations+in+Neuronal+Activity+of+Basal+Ganglia+Output+Nuclei+after+Dopamine+Cell+Lesion+in+Urethane+Anesthetized+Rats%3A+Exploring+Effects+on+Ventrolateral+Thalamus+and+Motor+Cortex&rft.au=Parr-Brownlie%2C+L+C%3BBergstrom%2C+D+A%3BItoga%2C+C+A%3BHu%2C+D.%3BSmith%2C+C.P.S.%3BWalters%2C+J+R&rft.aulast=Parr-Brownlie&rft.aufirst=L&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of GSK - 3 or HDAC Increases the Activity of BDNF Promoter III T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39934001; 4131901 JF - 35th Annual Meeting of the Society for Neuroscience AU - Yasuda, S AU - Liang, M H AU - Chuang, D M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Promoters KW - Histone deacetylase KW - Brain-derived neurotrophic factor KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39934001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Inhibition+of+GSK+-+3+or+HDAC+Increases+the+Activity+of+BDNF+Promoter+III&rft.au=Yasuda%2C+S%3BLiang%2C+M+H%3BChuang%2C+D+M&rft.aulast=Yasuda&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuronal Activity Promotes Conversion of Pro - to Mature Brain - Derived Neurotrophic Factor (BDNF) in the Dendrites of Hippocampal Neurons T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39932163; 4125353 JF - 35th Annual Meeting of the Society for Neuroscience AU - Nagappan, G AU - Zaitsev, E AU - Chang, J H AU - Lu, B. Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Brain-derived neurotrophic factor KW - Neurotrophic factors KW - Hippocampus KW - Neurons KW - Dendrites KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39932163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neuronal+Activity+Promotes+Conversion+of+Pro+-+to+Mature+Brain+-+Derived+Neurotrophic+Factor+%28BDNF%29+in+the+Dendrites+of+Hippocampal+Neurons&rft.au=Nagappan%2C+G%3BZaitsev%2C+E%3BChang%2C+J+H%3BLu%2C+B.&rft.aulast=Nagappan&rft.aufirst=G&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Cardiotrophin - 1 As a VIP and Choline Acetyltransferase - Inducing Factor in Extracts of Rat Footpads T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39930332; 4125330 JF - 35th Annual Meeting of the Society for Neuroscience AU - Coulombe, J N AU - Habecker, B AU - Guidry, G AU - McKinnon, L AU - Jaffe, H AU - Sun, Y E AU - Landis, S Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Vasoactive intestinal peptide KW - Choline O-acetyltransferase KW - Choline KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39930332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Identification+of+Cardiotrophin+-+1+As+a+VIP+and+Choline+Acetyltransferase+-+Inducing+Factor+in+Extracts+of+Rat+Footpads&rft.au=Coulombe%2C+J+N%3BHabecker%2C+B%3BGuidry%2C+G%3BMcKinnon%2C+L%3BJaffe%2C+H%3BSun%2C+Y+E%3BLandis%2C+S&rft.aulast=Coulombe&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Behavioral Phenotypes of Galanin Receptor Subtype 2 Null Mutant Mice T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39930111; 4134839 JF - 35th Annual Meeting of the Society for Neuroscience AU - Bailey, K R AU - Hohmann, J G AU - Pavlova, M AU - Crawley, J N Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Mice KW - Mutants KW - Galanin receptors KW - Phenotypes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39930111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Behavioral+Phenotypes+of+Galanin+Receptor+Subtype+2+Null+Mutant+Mice&rft.au=Bailey%2C+K+R%3BHohmann%2C+J+G%3BPavlova%2C+M%3BCrawley%2C+J+N&rft.aulast=Bailey&rft.aufirst=K&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a Novel Transmembrane Protein Important for Oligodendrocyte Membrane Formation Using Gene Expression Profiling T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39928010; 4132212 JF - 35th Annual Meeting of the Society for Neuroscience AU - Nielsen, J A AU - Maric, D AU - Lau, P AU - Barker, J L AU - Hudson, L D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Membrane proteins KW - Gene expression KW - Oligodendrocytes KW - Profiling KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39928010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Identification+of+a+Novel+Transmembrane+Protein+Important+for+Oligodendrocyte+Membrane+Formation+Using+Gene+Expression+Profiling&rft.au=Nielsen%2C+J+A%3BMaric%2C+D%3BLau%2C+P%3BBarker%2C+J+L%3BHudson%2C+L+D&rft.aulast=Nielsen&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Task Channels Mediate Leak Currents That Modulate Respiratory Rhythm Generation In Vitro T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39926956; 4132755 JF - 35th Annual Meeting of the Society for Neuroscience AU - Smerin, S E AU - Koizumi, H AU - Zhang, R AU - Moorjani, B AU - Smith, J C Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Channels KW - Respiration KW - Rhythms KW - Metabolism KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39926956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Task+Channels+Mediate+Leak+Currents+That+Modulate+Respiratory+Rhythm+Generation+In+Vitro&rft.au=Smerin%2C+S+E%3BKoizumi%2C+H%3BZhang%2C+R%3BMoorjani%2C+B%3BSmith%2C+J+C&rft.aulast=Smerin&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Specific Endosomal Associations During the Trafficking of Synaptic Glutamate Receptors T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39926613; 4133922 JF - 35th Annual Meeting of the Society for Neuroscience AU - Petralia, R S AU - Dunbar, L A AU - Wang, Y AU - Wenthold, R J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Glutamic acid receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39926613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Specific+Endosomal+Associations+During+the+Trafficking+of+Synaptic+Glutamate+Receptors&rft.au=Petralia%2C+R+S%3BDunbar%2C+L+A%3BWang%2C+Y%3BWenthold%2C+R+J&rft.aulast=Petralia&rft.aufirst=R&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Peripheral Nerve Stimulation (PNS) Enhances Learning of a Functional Motor Task in Chronic Stroke Patients T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39925938; 4129490 JF - 35th Annual Meeting of the Society for Neuroscience AU - Celnik, P A AU - Hummel, F AU - Harris-Love, M AU - Cohen, L G Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Peripheral nerves KW - Learning KW - Stroke KW - Peripheral nervous system KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39925938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Peripheral+Nerve+Stimulation+%28PNS%29+Enhances+Learning+of+a+Functional+Motor+Task+in+Chronic+Stroke+Patients&rft.au=Celnik%2C+P+A%3BHummel%2C+F%3BHarris-Love%2C+M%3BCohen%2C+L+G&rft.aulast=Celnik&rft.aufirst=P&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of the Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Receptor in Bovine Chromaffin Cells that Mediates Calcium - dependent Secretion T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39924423; 4130665 JF - 35th Annual Meeting of the Society for Neuroscience AU - Mustafa, T AU - Eiden, L E Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Calcium KW - Secretion KW - Pituitary adenylate cyclase-activating polypeptide KW - Chromaffin cells KW - Pituitary adenylate cyclase-activating polypeptide receptors KW - Polypeptides KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39924423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Characterization+of+the+Pituitary+Adenylate+Cyclase+Activating+Polypeptide+%28PACAP%29+Receptor+in+Bovine+Chromaffin+Cells+that+Mediates+Calcium+-+dependent+Secretion&rft.au=Mustafa%2C+T%3BEiden%2C+L+E&rft.aulast=Mustafa&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Degenerative Changes in the Peripheral Retina of Transgenic Animals Containing the Mutated Mouse Myocilin Gene T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39924328; 4126453 JF - 35th Annual Meeting of the Society for Neuroscience AU - Senatorov, V V AU - Malyukova, I V AU - Fariss, R N AU - Wawrousek, E F AU - Swaminathan, S AU - Sharan, S K AU - Tomarev, S I Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Retina KW - Transgenic animals KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39924328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Degenerative+Changes+in+the+Peripheral+Retina+of+Transgenic+Animals+Containing+the+Mutated+Mouse+Myocilin+Gene&rft.au=Senatorov%2C+V+V%3BMalyukova%2C+I+V%3BFariss%2C+R+N%3BWawrousek%2C+E+F%3BSwaminathan%2C+S%3BSharan%2C+S+K%3BTomarev%2C+S+I&rft.aulast=Senatorov&rft.aufirst=V&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Catechol - O - Methyltransferase val158met Genotype on Attentional Control T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39923908; 4132951 JF - 35th Annual Meeting of the Society for Neuroscience AU - Blasi, G AU - Mattay, V S AU - Bertolino, A AU - Elvevag, B AU - Callicott, J H AU - Das, S AU - Kolachana, B S AU - Egan, M F AU - Goldberg, T E AU - Weinberger, D R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Attention KW - Genotypes KW - Methyltransferase KW - Catechol KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39923908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effect+of+Catechol+-+O+-+Methyltransferase+val158met+Genotype+on+Attentional+Control&rft.au=Blasi%2C+G%3BMattay%2C+V+S%3BBertolino%2C+A%3BElvevag%2C+B%3BCallicott%2C+J+H%3BDas%2C+S%3BKolachana%2C+B+S%3BEgan%2C+M+F%3BGoldberg%2C+T+E%3BWeinberger%2C+D+R&rft.aulast=Blasi&rft.aufirst=G&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mouse Disabled - 1 Regulates Neuronal Nuclear Positioning in a Drosophila Eye Model T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39923901; 4132154 JF - 35th Annual Meeting of the Society for Neuroscience AU - Pramatarova, A AU - Ochalski, P G AU - Matsuki, T AU - Lee, C H AU - Howell, B W Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Eye KW - Positioning systems KW - Drosophila KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39923901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Mouse+Disabled+-+1+Regulates+Neuronal+Nuclear+Positioning+in+a+Drosophila+Eye+Model&rft.au=Pramatarova%2C+A%3BOchalski%2C+P+G%3BMatsuki%2C+T%3BLee%2C+C+H%3BHowell%2C+B+W&rft.aulast=Pramatarova&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lithium Normalizes Dendritic Localization of val66met Polymorphism of Brain - derived Neurotrophic Factor ( BDNFmet ): Therapeutic Implications T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39923787; 4131893 JF - 35th Annual Meeting of the Society for Neuroscience AU - Du, J. AU - Suzuki, K AU - Guhan, N AU - Wei, Y AU - Wu, J. AU - Lu, B. AU - Manji, H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Lithium KW - Brain KW - Neurotrophic factors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39923787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Lithium+Normalizes+Dendritic+Localization+of+val66met+Polymorphism+of+Brain+-+derived+Neurotrophic+Factor+%28+BDNFmet+%29%3A+Therapeutic+Implications&rft.au=Du%2C+J.%3BSuzuki%2C+K%3BGuhan%2C+N%3BWei%2C+Y%3BWu%2C+J.%3BLu%2C+B.%3BManji%2C+H&rft.aulast=Du&rft.aufirst=J.&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - 5'UTR of BDNF Transcript Dictates mRNA Trafficking and Local Translation in Dendrites of Hippocampal Neurons T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39922370; 4125352 JF - 35th Annual Meeting of the Society for Neuroscience AU - Zaitsev, E N AU - Guhan, N AU - Yang, F AU - Lu, B. Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Translation KW - Transcription KW - 5' Untranslated regions KW - Brain-derived neurotrophic factor KW - Hippocampus KW - Neurons KW - Dendrites KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39922370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=5%27UTR+of+BDNF+Transcript+Dictates+mRNA+Trafficking+and+Local+Translation+in+Dendrites+of+Hippocampal+Neurons&rft.au=Zaitsev%2C+E+N%3BGuhan%2C+N%3BYang%2C+F%3BLu%2C+B.&rft.aulast=Zaitsev&rft.aufirst=E&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Striatal Volumes in Young Alcoholics and Children of Alcoholics T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39921822; 4121745 JF - 35th Annual Meeting of the Society for Neuroscience AU - Hommer, D W AU - Momenan, R AU - Bjork, J M AU - Kerich, M J AU - Israe, M E Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Children KW - Alcoholics KW - Neostriatum KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39921822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Striatal+Volumes+in+Young+Alcoholics+and+Children+of+Alcoholics&rft.au=Hommer%2C+D+W%3BMomenan%2C+R%3BBjork%2C+J+M%3BKerich%2C+M+J%3BIsrae%2C+M+E&rft.aulast=Hommer&rft.aufirst=D&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Measurement of Trophins, Peptides and Cytokines in Blood of Down Syndrome and Autistic Newborns and Controls T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39919058; 4128513 JF - 35th Annual Meeting of the Society for Neuroscience AU - Nelson, P G AU - Kuddo, T AU - Song, E AU - Dambrosia, J AU - Kohler, S AU - Satyanarayana, G AU - VanDunk, C AU - Grether, J AU - Nelson, K B Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Blood KW - Cytokines KW - Down's syndrome KW - Neonates KW - Peptides KW - Symptoms KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39919058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Measurement+of+Trophins%2C+Peptides+and+Cytokines+in+Blood+of+Down+Syndrome+and+Autistic+Newborns+and+Controls&rft.au=Nelson%2C+P+G%3BKuddo%2C+T%3BSong%2C+E%3BDambrosia%2C+J%3BKohler%2C+S%3BSatyanarayana%2C+G%3BVanDunk%2C+C%3BGrether%2C+J%3BNelson%2C+K+B&rft.aulast=Nelson&rft.aufirst=P&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Odorant - induced Activity Accelerates Glomerular Refinement in the Mammalian Olfactory Bulb T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39918816; 4129011 JF - 35th Annual Meeting of the Society for Neuroscience AU - Kerr, M A AU - Belluscio, L Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Odors KW - Odorants KW - Olfactory bulb KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39918816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Odorant+-+induced+Activity+Accelerates+Glomerular+Refinement+in+the+Mammalian+Olfactory+Bulb&rft.au=Kerr%2C+M+A%3BBelluscio%2C+L&rft.aulast=Kerr&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Endogenous and Exogenous Cannabinoids Potentiate Glycine Receptor - mediated Responses Through a CB Receptor Independent Mechanism in Xenopus Oocytes T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39918365; 4130648 JF - 35th Annual Meeting of the Society for Neuroscience AU - Sun, H AU - Hejazi, N AU - Oz, M. AU - Zhang, L Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Oocytes KW - Glycine receptors KW - Amphibiotic species KW - Xenopus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39918365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Endogenous+and+Exogenous+Cannabinoids+Potentiate+Glycine+Receptor+-+mediated+Responses+Through+a+CB+Receptor+Independent+Mechanism+in+Xenopus+Oocytes&rft.au=Sun%2C+H%3BHejazi%2C+N%3BOz%2C+M.%3BZhang%2C+L&rft.aulast=Sun&rft.aufirst=H&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Experimental Strategy that Allows the Identification of Functionally Critical Amino Acids in the M3 Muscarinic Acetylcholine Receptor 149 G-Protein-Linked Receptors: Muscarinic T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39918180; 4122106 JF - 35th Annual Meeting of the Society for Neuroscience AU - Li, B. AU - Scarselli, M AU - Knudsen, C D AU - McMillin, S M AU - Wess, J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Amino acids KW - Acetylcholine receptors (muscarinic) KW - Neurotransmitters KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39918180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=A+Novel+Experimental+Strategy+that+Allows+the+Identification+of+Functionally+Critical+Amino+Acids+in+the+M3+Muscarinic+Acetylcholine+Receptor+149+G-Protein-Linked+Receptors%3A+Muscarinic&rft.au=Li%2C+B.%3BScarselli%2C+M%3BKnudsen%2C+C+D%3BMcMillin%2C+S+M%3BWess%2C+J&rft.aulast=Li&rft.aufirst=B.&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Maturation of GABA@@dA@ Receptor - Mediated Synaptic Transmission in Adult - Born Dentate Gyrus Granule Cells T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39917578; 4121992 JF - 35th Annual Meeting of the Society for Neuroscience AU - Karten, Y.J.G. AU - Brewer, M D AU - Dayer, A G AU - Cameron, H A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Granule cells KW - ^g-Aminobutyric acid A receptors KW - Synaptic transmission KW - Dentate gyrus KW - Sexual maturity KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39917578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Maturation+of+GABA%40%40dA%40+Receptor+-+Mediated+Synaptic+Transmission+in+Adult+-+Born+Dentate+Gyrus+Granule+Cells&rft.au=Karten%2C+Y.J.G.%3BBrewer%2C+M+D%3BDayer%2C+A+G%3BCameron%2C+H+A&rft.aulast=Karten&rft.aufirst=Y.J.G.&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Are Task Channels a Target for Muscarinic Modulation in Hippocampal Interneurons? T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39917298; 4128928 JF - 35th Annual Meeting of the Society for Neuroscience AU - Torborg, C L AU - Lawrence, J AU - Jeffries, B AU - Berg, A P AU - Bayliss, D A AU - McBain, C J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Channels KW - Interneurons KW - Hippocampus KW - Acetylcholine receptors (muscarinic) KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39917298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Are+Task+Channels+a+Target+for+Muscarinic+Modulation+in+Hippocampal+Interneurons%3F&rft.au=Torborg%2C+C+L%3BLawrence%2C+J%3BJeffries%2C+B%3BBerg%2C+A+P%3BBayliss%2C+D+A%3BMcBain%2C+C+J&rft.aulast=Torborg&rft.aufirst=C&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reduced Prefrontal g - Aminobutyric Acid Levels in Patients with Current Major Depression Determined by Proton Magnetic Resonance Spectroscopy T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39913630; 4119166 JF - 35th Annual Meeting of the Society for Neuroscience AU - Hasler, G AU - van der Veen, J AU - Tumonis, T AU - Shen, J AU - Drevets, W Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Spectroscopy KW - Depression KW - Magnetic resonance spectroscopy KW - Resonance KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39913630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Reduced+Prefrontal+g+-+Aminobutyric+Acid+Levels+in+Patients+with+Current+Major+Depression+Determined+by+Proton+Magnetic+Resonance+Spectroscopy&rft.au=Hasler%2C+G%3Bvan+der+Veen%2C+J%3BTumonis%2C+T%3BShen%2C+J%3BDrevets%2C+W&rft.aulast=Hasler&rft.aufirst=G&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamics of Ca@@u2+@ Signals in Soma and Dendrities Due to Activation of Nicotinic Acetylcholine Receptors in Rat Hippocampal Interneurons T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39913496; 4133986 JF - 35th Annual Meeting of the Society for Neuroscience AU - Fayuk, D A AU - Yakel, J L Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Acetylcholine receptors (nicotinic) KW - Interneurons KW - Hippocampus KW - Calcium signalling KW - Neurotransmitters KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39913496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Dynamics+of+Ca%40%40u2%2B%40+Signals+in+Soma+and+Dendrities+Due+to+Activation+of+Nicotinic+Acetylcholine+Receptors+in+Rat+Hippocampal+Interneurons&rft.au=Fayuk%2C+D+A%3BYakel%2C+J+L&rft.aulast=Fayuk&rft.aufirst=D&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Local Protein Synthesis on Axonal Mitochondria in Superior Cervical Ganglion Neurons T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39912995; 4127094 JF - 35th Annual Meeting of the Society for Neuroscience AU - Hillefors, M S AU - Gioio, A E AU - Kaplan, B B Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Superior cervical ganglion KW - Protein biosynthesis KW - Mitochondria KW - Neurons KW - Protein synthesis KW - Ganglia KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39912995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effects+of+Local+Protein+Synthesis+on+Axonal+Mitochondria+in+Superior+Cervical+Ganglion+Neurons&rft.au=Hillefors%2C+M+S%3BGioio%2C+A+E%3BKaplan%2C+B+B&rft.aulast=Hillefors&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modulation of Neuronal Activity in the Pre - Botzinger Complex by Medullary Raphe Neurons T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39912747; 4127796 JF - 35th Annual Meeting of the Society for Neuroscience AU - Ptak, K AU - Milescu, L S AU - Richerson, G B AU - Smith, J C Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Neuromodulation KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39912747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Modulation+of+Neuronal+Activity+in+the+Pre+-+Botzinger+Complex+by+Medullary+Raphe+Neurons&rft.au=Ptak%2C+K%3BMilescu%2C+L+S%3BRicherson%2C+G+B%3BSmith%2C+J+C&rft.aulast=Ptak&rft.aufirst=K&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Role for PICK1 - Dependent GluR2 Trafficking in Depolarization - Induced Depression (DID) at Hippocampal Mossy Fiber - - CA3 Pyramid Synapses T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39911516; 4125572 JF - 35th Annual Meeting of the Society for Neuroscience AU - Ho, T W AU - Pelkey, K A AU - Takamiya, K AU - Xia, J AU - Huganir, R L AU - McBain, C J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Fibers KW - Depression KW - Synaptic depression KW - ^a-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors KW - Hippocampus KW - Mossy fibers KW - Synapses KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39911516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=A+Role+for+PICK1+-+Dependent+GluR2+Trafficking+in+Depolarization+-+Induced+Depression+%28DID%29+at+Hippocampal+Mossy+Fiber+-+-+CA3+Pyramid+Synapses&rft.au=Ho%2C+T+W%3BPelkey%2C+K+A%3BTakamiya%2C+K%3BXia%2C+J%3BHuganir%2C+R+L%3BMcBain%2C+C+J&rft.aulast=Ho&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuregulin - 1 Depotentiates LTP at Hippocampal CA1 Synapses T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39911235; 4127329 JF - 35th Annual Meeting of the Society for Neuroscience AU - Buonanno, A AU - Kwon, O AU - Longart, M AU - Hoffman, D AU - Vullhorst, D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Long-term potentiation KW - Neuregulin KW - Synapses KW - Hippocampus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39911235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neuregulin+-+1+Depotentiates+LTP+at+Hippocampal+CA1+Synapses&rft.au=Buonanno%2C+A%3BKwon%2C+O%3BLongart%2C+M%3BHoffman%2C+D%3BVullhorst%2C+D&rft.aulast=Buonanno&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of a Truncated Isoform of Human Metabotropic Glutamate Receptor 3 T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39910629; 4120241 JF - 35th Annual Meeting of the Society for Neuroscience AU - Sartorius, L J AU - Lipska, B K AU - Sei, Y AU - Ren-Patterson, R AU - Kleinman, J E AU - Harrison, P J AU - Weinberger, D R AU - Lu, B. Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Glutamic acid receptors (metabotropic) KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39910629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Characterization+of+a+Truncated+Isoform+of+Human+Metabotropic+Glutamate+Receptor+3&rft.au=Sartorius%2C+L+J%3BLipska%2C+B+K%3BSei%2C+Y%3BRen-Patterson%2C+R%3BKleinman%2C+J+E%3BHarrison%2C+P+J%3BWeinberger%2C+D+R%3BLu%2C+B.&rft.aulast=Sartorius&rft.aufirst=L&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Motor Cortical Oscillatory Activation Patterns in Ipsilateral Versus Contralateral Self - Paced Movements: An ECoG Study T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39909418; 4124561 JF - 35th Annual Meeting of the Society for Neuroscience AU - Mari, Z AU - Matsuhashi, M AU - Wheaton, L AU - Sato, S AU - Hallett, M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Self KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39909418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Human+Motor+Cortical+Oscillatory+Activation+Patterns+in+Ipsilateral+Versus+Contralateral+Self+-+Paced+Movements%3A+An+ECoG+Study&rft.au=Mari%2C+Z%3BMatsuhashi%2C+M%3BWheaton%2C+L%3BSato%2C+S%3BHallett%2C+M&rft.aulast=Mari&rft.aufirst=Z&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuronal Excess of Ferroxidase - active Ferritin Causes Late - onset Neurodegeneration in Drosophila T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39908579; 4129957 JF - 35th Annual Meeting of the Society for Neuroscience AU - Missirlis, F AU - Kosmidis, S AU - Botella, J A AU - Schnewuly, S AU - Skoulakis, E.M.C. AU - Rouault, T A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Neurodegeneration KW - Ferritin KW - Ferroxidase KW - Drosophila KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39908579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neuronal+Excess+of+Ferroxidase+-+active+Ferritin+Causes+Late+-+onset+Neurodegeneration+in+Drosophila&rft.au=Missirlis%2C+F%3BKosmidis%2C+S%3BBotella%2C+J+A%3BSchnewuly%2C+S%3BSkoulakis%2C+E.M.C.%3BRouault%2C+T+A&rft.aulast=Missirlis&rft.aufirst=F&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - GnRH - 1 Regulates GnRH - 1 Neurons T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39907769; 4127755 JF - 35th Annual Meeting of the Society for Neuroscience AU - Duittoz, A AU - Constantin, S AU - Skinner, D AU - Wray, S Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Gonadotropin-releasing hormone KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39907769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=GnRH+-+1+Regulates+GnRH+-+1+Neurons&rft.au=Duittoz%2C+A%3BConstantin%2C+S%3BSkinner%2C+D%3BWray%2C+S&rft.aulast=Duittoz&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of Corticotrophin - Releasing Hormone Transcription by Inducible cAMP Early Repressor(ICER) T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39906280; 4119158 JF - 35th Annual Meeting of the Society for Neuroscience AU - Liu, Y AU - Aguilera, G Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Hormones KW - Transcription KW - Cyclic AMP KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39906280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Inhibition+of+Corticotrophin+-+Releasing+Hormone+Transcription+by+Inducible+cAMP+Early+Repressor%28ICER%29&rft.au=Liu%2C+Y%3BAguilera%2C+G&rft.aulast=Liu&rft.aufirst=Y&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effects of Cholecystokinin on Ventral Neurons in the Spinal Cord of the Neonatal Rat and Mouse T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39906265; 4129288 JF - 35th Annual Meeting of the Society for Neuroscience AU - Yang, K AU - Morales, M AU - Renaud, L P AU - O'Donovan, M J AU - Lupica, C R AU - Oz, M. Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Spinal cord KW - Cholecystokinin KW - Neonates KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39906265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Effects+of+Cholecystokinin+on+Ventral+Neurons+in+the+Spinal+Cord+of+the+Neonatal+Rat+and+Mouse&rft.au=Yang%2C+K%3BMorales%2C+M%3BRenaud%2C+L+P%3BO%27Donovan%2C+M+J%3BLupica%2C+C+R%3BOz%2C+M.&rft.aulast=Yang&rft.aufirst=K&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - EEG Coherence Analysis of Visuomotor Networks: Distinguishable Paths in the Brain for Varying Processing Demands T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39905777; 4124273 JF - 35th Annual Meeting of the Society for Neuroscience AU - Wheaton, L A AU - Hattori, N AU - Hallett, M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Brain KW - Oculomotor behavior KW - EEG KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39905777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=EEG+Coherence+Analysis+of+Visuomotor+Networks%3A+Distinguishable+Paths+in+the+Brain+for+Varying+Processing+Demands&rft.au=Wheaton%2C+L+A%3BHattori%2C+N%3BHallett%2C+M&rft.aulast=Wheaton&rft.aufirst=L&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rhesus Monkeys with Orbital Prefrontal Cortex Lesions can Learn to Inhibit Prepotent Responses in the Reversed - Reward Contingency Task T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39903525; 4134857 JF - 35th Annual Meeting of the Society for Neuroscience AU - Chudasama, Y AU - Kralik, J D AU - Murray, E A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Lesions KW - Reinforcement KW - Contingency KW - Cortex (prefrontal) KW - Macaca mulatta KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39903525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Rhesus+Monkeys+with+Orbital+Prefrontal+Cortex+Lesions+can+Learn+to+Inhibit+Prepotent+Responses+in+the+Reversed+-+Reward+Contingency+Task&rft.au=Chudasama%2C+Y%3BKralik%2C+J+D%3BMurray%2C+E+A&rft.aulast=Chudasama&rft.aufirst=Y&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PKC and GRK Regulation of D@@d1@ Dopamine Receptor Signaling T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39903158; 4120259 JF - 35th Annual Meeting of the Society for Neuroscience AU - Rankin, M L AU - Sibley, D R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Signal transduction KW - Dopamine D1 receptors KW - Protein kinase C KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39903158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=PKC+and+GRK+Regulation+of+D%40%40d1%40+Dopamine+Receptor+Signaling&rft.au=Rankin%2C+M+L%3BSibley%2C+D+R&rft.aulast=Rankin&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - D@@d1@ Dopamine Receptor Expression is Regulated by Direct Interaction with the Chaperone Protein Calnexin T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39903095; 4120258 JF - 35th Annual Meeting of the Society for Neuroscience AU - Free, R B AU - Hazelwood, L A AU - Cabrera, D M AU - Spalding, H N AU - Sibley, D R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Chaperones KW - Dopamine D1 receptors KW - Calnexin KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39903095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=D%40%40d1%40+Dopamine+Receptor+Expression+is+Regulated+by+Direct+Interaction+with+the+Chaperone+Protein+Calnexin&rft.au=Free%2C+R+B%3BHazelwood%2C+L+A%3BCabrera%2C+D+M%3BSpalding%2C+H+N%3BSibley%2C+D+R&rft.aulast=Free&rft.aufirst=R&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Two Neural Circuits for Learning DNMS with Short Delays T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39902440; 4120885 JF - 35th Annual Meeting of the Society for Neuroscience AU - Malloy, M M AU - Turchi, J AU - Lowther, R AU - Yu, D. AU - Saunders, R C AU - Mishkin, M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Learning KW - Neural networks KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39902440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Two+Neural+Circuits+for+Learning+DNMS+with+Short+Delays&rft.au=Malloy%2C+M+M%3BTurchi%2C+J%3BLowther%2C+R%3BYu%2C+D.%3BSaunders%2C+R+C%3BMishkin%2C+M&rft.aulast=Malloy&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dissociation of Emotion-Laden and Cognitive Prefrontal Cortical Activity T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39901759; 4122904 JF - 35th Annual Meeting of the Society for Neuroscience AU - Goldman, A L AU - Pezawas, L AU - Chen, G AU - Meyer-Lindenberg, A AU - Goldberg, T E AU - Saad, Z S AU - Mattay, V S AU - Weinberger, D R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Cognitive ability KW - Dissociation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39901759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Dissociation+of+Emotion-Laden+and+Cognitive+Prefrontal+Cortical+Activity&rft.au=Goldman%2C+A+L%3BPezawas%2C+L%3BChen%2C+G%3BMeyer-Lindenberg%2C+A%3BGoldberg%2C+T+E%3BSaad%2C+Z+S%3BMattay%2C+V+S%3BWeinberger%2C+D+R&rft.aulast=Goldman&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Suppressive Effect of Peripheral Stimulation on Corticospinal Excitability Decreases for Muscle Involved in a Motor - Learning Task T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39901378; 4122563 JF - 35th Annual Meeting of the Society for Neuroscience AU - Russmann, H AU - Meunier, S O AU - Hallett, M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Muscles KW - Motor skill learning KW - Pyramidal tracts KW - Excitability KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39901378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Suppressive+Effect+of+Peripheral+Stimulation+on+Corticospinal+Excitability+Decreases+for+Muscle+Involved+in+a+Motor+-+Learning+Task&rft.au=Russmann%2C+H%3BMeunier%2C+S+O%3BHallett%2C+M&rft.aulast=Russmann&rft.aufirst=H&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Brain Metabolic Fluctuations During Sleep T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39900839; 4122826 JF - 35th Annual Meeting of the Society for Neuroscience AU - Fukunaga, M AU - Horovitz, S G AU - van Gelderen, P AU - de Zwart, J.A. AU - Duyn, J H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Brain KW - Sleep KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39900839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Brain+Metabolic+Fluctuations+During+Sleep&rft.au=Fukunaga%2C+M%3BHorovitz%2C+S+G%3Bvan+Gelderen%2C+P%3Bde+Zwart%2C+J.A.%3BDuyn%2C+J+H&rft.aulast=Fukunaga&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oxidative Modifications of CaMKII Inhibit its Autophosphorylation T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39900460; 4123301 JF - 35th Annual Meeting of the Society for Neuroscience AU - Shetty, P K AU - Huang, F AU - Huang, K Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Ca@@u2+@/calmodulin-dependent protein kinase II KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39900460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Oxidative+Modifications+of+CaMKII+Inhibit+its+Autophosphorylation&rft.au=Shetty%2C+P+K%3BHuang%2C+F%3BHuang%2C+K&rft.aulast=Shetty&rft.aufirst=P&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Identification of Distinct Populations of Neurons Involved in Drosophila Wing Expansion T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39899903; 4120670 JF - 35th Annual Meeting of the Society for Neuroscience AU - Lemon, W C AU - Luan, H AU - Nitabach, M N AU - Holmes, T C AU - White, B H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Wings KW - Neurons KW - Drosophila KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39899903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Functional+Identification+of+Distinct+Populations+of+Neurons+Involved+in+Drosophila+Wing+Expansion&rft.au=Lemon%2C+W+C%3BLuan%2C+H%3BNitabach%2C+M+N%3BHolmes%2C+T+C%3BWhite%2C+B+H&rft.aulast=Lemon&rft.aufirst=W&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Scopolamine Differentially Modulates Attention and Emotion T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39899850; 4128009 JF - 35th Annual Meeting of the Society for Neuroscience AU - Furey, M L AU - Drevets, W C Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Scopolamine KW - Emotions KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39899850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Scopolamine+Differentially+Modulates+Attention+and+Emotion&rft.au=Furey%2C+M+L%3BDrevets%2C+W+C&rft.aulast=Furey&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microglial NADPH Oxidase is the Target of Femtomolar Neuroprotection Against Oxidative Stress for GIF, Tripeptide of PACAP - 38 T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39899791; 4133904 JF - 35th Annual Meeting of the Society for Neuroscience AU - Yang, S Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Stress KW - Oxidative stress KW - NADPH oxidase KW - Pituitary adenylate cyclase-activating polypeptide KW - Neuroprotection KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39899791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Microglial+NADPH+Oxidase+is+the+Target+of+Femtomolar+Neuroprotection+Against+Oxidative+Stress+for+GIF%2C+Tripeptide+of+PACAP+-+38&rft.au=Yang%2C+S&rft.aulast=Yang&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Neuroimaging of Ambiguous Haplotypes Reveals Impact of Genetic Variation in COMT on Prefrontal Function T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39899419; 4126070 JF - 35th Annual Meeting of the Society for Neuroscience AU - Meyer-Lindenberg, A S AU - Nichols, T AU - Callicott, J AU - Ding, J AU - Kolachana, B AU - Buckholtz, J AU - Straub, R AU - Mattay, V S AU - Egan, M AU - Weinberger, D R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Neuroimaging KW - Haplotypes KW - Genetic diversity KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39899419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Functional+Neuroimaging+of+Ambiguous+Haplotypes+Reveals+Impact+of+Genetic+Variation+in+COMT+on+Prefrontal+Function&rft.au=Meyer-Lindenberg%2C+A+S%3BNichols%2C+T%3BCallicott%2C+J%3BDing%2C+J%3BKolachana%2C+B%3BBuckholtz%2C+J%3BStraub%2C+R%3BMattay%2C+V+S%3BEgan%2C+M%3BWeinberger%2C+D+R&rft.aulast=Meyer-Lindenberg&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - COMT val@@u158@met Polymorphism Impacts on Reactivity of Amygdala to Emotion - Laden Stimuli T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39899068; 4123022 JF - 35th Annual Meeting of the Society for Neuroscience AU - Mattay, V S AU - Blasi, G AU - Alce, G AU - Das, S AU - Callicott, J H AU - Kolachana, B S AU - Egan, M F AU - Sambataro, F AU - Meyer-Lindenberg, A AU - Hariri, A R AU - Weinberger, D R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Amygdala KW - Emotions KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39899068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=COMT+val%40%40u158%40met+Polymorphism+Impacts+on+Reactivity+of+Amygdala+to+Emotion+-+Laden+Stimuli&rft.au=Mattay%2C+V+S%3BBlasi%2C+G%3BAlce%2C+G%3BDas%2C+S%3BCallicott%2C+J+H%3BKolachana%2C+B+S%3BEgan%2C+M+F%3BSambataro%2C+F%3BMeyer-Lindenberg%2C+A%3BHariri%2C+A+R%3BWeinberger%2C+D+R&rft.aulast=Mattay&rft.aufirst=V&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ethanol Inhibits BDNF - Stimulated ERK Activation in Cerebellar Granule Cells T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39898550; 4123670 JF - 35th Annual Meeting of the Society for Neuroscience AU - Davis, M I AU - Ohrtman, J D AU - Stancik, E K AU - Lovinger, D M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Ethanol KW - Granule cells KW - Cerebellum KW - Brain-derived neurotrophic factor KW - Extracellular signal-regulated kinase KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39898550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Ethanol+Inhibits+BDNF+-+Stimulated+ERK+Activation+in+Cerebellar+Granule+Cells&rft.au=Davis%2C+M+I%3BOhrtman%2C+J+D%3BStancik%2C+E+K%3BLovinger%2C+D+M&rft.aulast=Davis&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rapid Antibody Staining of GnRH - 1 Neurons for Subsequent Laser - Capture Microdissection and RT - PCR Analysis T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39898340; 4127754 JF - 35th Annual Meeting of the Society for Neuroscience AU - Reuss, A E AU - Wray, S Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Lasers KW - Antibodies KW - Polymerase chain reaction KW - Neurons KW - Gonadotropin-releasing hormone KW - Nucleotide sequence KW - Staining KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39898340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Rapid+Antibody+Staining+of+GnRH+-+1+Neurons+for+Subsequent+Laser+-+Capture+Microdissection+and+RT+-+PCR+Analysis&rft.au=Reuss%2C+A+E%3BWray%2C+S&rft.aulast=Reuss&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Action Potential - Dependent Signaling between Axons and Glia T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39897675; 4125649 JF - 35th Annual Meeting of the Society for Neuroscience AU - Lee, P R AU - Fields, R D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Signal transduction KW - Action potential KW - Glia KW - Axons KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39897675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Action+Potential+-+Dependent+Signaling+between+Axons+and+Glia&rft.au=Lee%2C+P+R%3BFields%2C+R+D&rft.aulast=Lee&rft.aufirst=P&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Kinetics of Penetration Influence the Apparent Potency of Vanilloids on TRPV1 T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39896380; 4125787 JF - 35th Annual Meeting of the Society for Neuroscience AU - Lazar, J AU - Braun, D C AU - Toth, A AU - Wang, Y AU - Pearce, L V AU - Pavlyukovets, V A AU - Choi, H AU - Lee, J AU - Blumberg, P M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Kinetics KW - Capsaicin receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39896380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Kinetics+of+Penetration+Influence+the+Apparent+Potency+of+Vanilloids+on+TRPV1&rft.au=Lazar%2C+J%3BBraun%2C+D+C%3BToth%2C+A%3BWang%2C+Y%3BPearce%2C+L+V%3BPavlyukovets%2C+V+A%3BChoi%2C+H%3BLee%2C+J%3BBlumberg%2C+P+M&rft.aulast=Lazar&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selectivity for Cyclopean Contours in Macaque V2 Reflects Properties of a Simple Mechanism, Rather than High - Level Edge Representation T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39896310; 4119578 JF - 35th Annual Meeting of the Society for Neuroscience AU - Bredfeldt, C E AU - Cumming, B G Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Macaca KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39896310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Selectivity+for+Cyclopean+Contours+in+Macaque+V2+Reflects+Properties+of+a+Simple+Mechanism%2C+Rather+than+High+-+Level+Edge+Representation&rft.au=Bredfeldt%2C+C+E%3BCumming%2C+B+G&rft.aulast=Bredfeldt&rft.aufirst=C&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - COMT Val158Met Genotype and IQ Interact to Predict BOLD Response to Working Memory Challenge in Prefrontal Cortex T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39894790; 4126068 JF - 35th Annual Meeting of the Society for Neuroscience AU - Buckholtz, J W AU - Meyer-Lindenberg, A AU - Tan, H Y AU - Sust, S AU - Egan, M F AU - Goldberg, T E AU - Mattay, V S AU - Kolachana, B AU - Weinberger, D R AU - Callicott, J H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Short term memory KW - Cortex (prefrontal) KW - Genotypes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39894790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=COMT+Val158Met+Genotype+and+IQ+Interact+to+Predict+BOLD+Response+to+Working+Memory+Challenge+in+Prefrontal+Cortex&rft.au=Buckholtz%2C+J+W%3BMeyer-Lindenberg%2C+A%3BTan%2C+H+Y%3BSust%2C+S%3BEgan%2C+M+F%3BGoldberg%2C+T+E%3BMattay%2C+V+S%3BKolachana%2C+B%3BWeinberger%2C+D+R%3BCallicott%2C+J+H&rft.aulast=Buckholtz&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Chemical - Library Approach to Mining the Receptorome T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39893866; 4125398 JF - 35th Annual Meeting of the Society for Neuroscience AU - Roth, B L AU - Birkes, J A AU - Evans, J AU - Kroeze, W K AU - Fan, Y AU - Beeler, A A AU - Panek, J S AU - Schaus, S E AU - Snyder, J K AU - Porco, J A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Mining KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39893866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=A+Chemical+-+Library+Approach+to+Mining+the+Receptorome&rft.au=Roth%2C+B+L%3BBirkes%2C+J+A%3BEvans%2C+J%3BKroeze%2C+W+K%3BFan%2C+Y%3BBeeler%2C+A+A%3BPanek%2C+J+S%3BSchaus%2C+S+E%3BSnyder%2C+J+K%3BPorco%2C+J+A&rft.aulast=Roth&rft.aufirst=B&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distinct Electrophysiological Properties of Hippocampal CA2 Neurons 162 LTP Postsynaptic Mechanisms: Cellular Physiology T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39893501; 4122326 JF - 35th Annual Meeting of the Society for Neuroscience AU - Zhao, M AU - Dudek, S M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Physiology KW - Long-term potentiation KW - Hippocampus KW - Neurons KW - Electrophysiology KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39893501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Distinct+Electrophysiological+Properties+of+Hippocampal+CA2+Neurons+162+LTP+Postsynaptic+Mechanisms%3A+Cellular+Physiology&rft.au=Zhao%2C+M%3BDudek%2C+S+M&rft.aulast=Zhao&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Situ Hybridization Analysis of Changes in Heteronuclear Oxytocin and Vasopressin RNA During Lactation and the Estrous Cycle in the Rat Hypothalamus T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39893324; 4134728 JF - 35th Annual Meeting of the Society for Neuroscience AU - Scordalakes, E M AU - Yue, C AU - Mutsuga, N AU - Gainer, H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Lactation KW - RNA KW - Oxytocin KW - Vasopressin KW - Hybridization analysis KW - Hypothalamus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39893324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=In+Situ+Hybridization+Analysis+of+Changes+in+Heteronuclear+Oxytocin+and+Vasopressin+RNA+During+Lactation+and+the+Estrous+Cycle+in+the+Rat+Hypothalamus&rft.au=Scordalakes%2C+E+M%3BYue%2C+C%3BMutsuga%2C+N%3BGainer%2C+H&rft.aulast=Scordalakes&rft.aufirst=E&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Analysis in Adult Rat Hypothalamus Using an In Vivo Electroporation Technique T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39893212; 4134707 JF - 35th Annual Meeting of the Society for Neuroscience AU - Mutsuga-Nakayama, N AU - Wei, F AU - Fields, R L AU - Gainer, H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Electroporation KW - Gene expression KW - Hypothalamus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39893212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Gene+Expression+Analysis+in+Adult+Rat+Hypothalamus+Using+an+In+Vivo+Electroporation+Technique&rft.au=Mutsuga-Nakayama%2C+N%3BWei%2C+F%3BFields%2C+R+L%3BGainer%2C+H&rft.aulast=Mutsuga-Nakayama&rft.aufirst=N&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In the Act of Feeding: A Model of Reward, Decision, and Inhibitory Control T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39892836; 4134856 JF - 35th Annual Meeting of the Society for Neuroscience AU - Kralik, J D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Reinforcement KW - Feeding KW - Models KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39892836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=In+the+Act+of+Feeding%3A+A+Model+of+Reward%2C+Decision%2C+and+Inhibitory+Control&rft.au=Kralik%2C+J+D&rft.aulast=Kralik&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Repopulation of Dentate Granule Neurons Following Trimethyltin - Induced Injury in the Adolescent Mouse T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39891989; 4128299 JF - 35th Annual Meeting of the Society for Neuroscience AU - Aoyama, M AU - Wine, R N AU - McPherson, C A AU - Harry, G J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Adolescents KW - Injuries KW - Granule cells KW - Trimethyltin KW - Repopulation KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39891989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Repopulation+of+Dentate+Granule+Neurons+Following+Trimethyltin+-+Induced+Injury+in+the+Adolescent+Mouse&rft.au=Aoyama%2C+M%3BWine%2C+R+N%3BMcPherson%2C+C+A%3BHarry%2C+G+J&rft.aulast=Aoyama&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PKB Phosphorylation of the NMDA Receptor NR2C Subunit and Binding to 14 - 3 - 3e T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39891084; 4132395 JF - 35th Annual Meeting of the Society for Neuroscience AU - Chen, B AU - Roche, K W Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Glutamic acid receptors KW - N-Methyl-D-aspartic acid receptors KW - Phosphorylation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39891084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=PKB+Phosphorylation+of+the+NMDA+Receptor+NR2C+Subunit+and+Binding+to+14+-+3+-+3e&rft.au=Chen%2C+B%3BRoche%2C+K+W&rft.aulast=Chen&rft.aufirst=B&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modeling the Behavior of Monkeys in Reward Schedules with Context - Dependent and Adaptive Reinforcement Learning T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39889622; 4134853 JF - 35th Annual Meeting of the Society for Neuroscience AU - La Camera, G. AU - Zeng, L AU - Pritchett, D L AU - Richmond, B J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Reinforcement KW - Learning KW - Learning behaviour KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39889622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Modeling+the+Behavior+of+Monkeys+in+Reward+Schedules+with+Context+-+Dependent+and+Adaptive+Reinforcement+Learning&rft.au=La+Camera%2C+G.%3BZeng%2C+L%3BPritchett%2C+D+L%3BRichmond%2C+B+J&rft.aulast=La+Camera&rft.aufirst=G.&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cue and Reward Signals Carried by Monkey Entorhinal Neurons during Reward Schedules T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39889573; 4134852 JF - 35th Annual Meeting of the Society for Neuroscience AU - Sugase-Miyamoto, Y AU - Richmond, B J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Reinforcement KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39889573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Cue+and+Reward+Signals+Carried+by+Monkey+Entorhinal+Neurons+during+Reward+Schedules&rft.au=Sugase-Miyamoto%2C+Y%3BRichmond%2C+B+J&rft.aulast=Sugase-Miyamoto&rft.aufirst=Y&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Co - Existence of g - Oscillations and Neuronal Avalanches in Cortical Networks T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39889543; 4134283 JF - 35th Annual Meeting of the Society for Neuroscience AU - Gireesh, E.Dharmaraj AU - Plenz, D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Avalanches KW - Oscillations KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39889543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Co+-+Existence+of+g+-+Oscillations+and+Neuronal+Avalanches+in+Cortical+Networks&rft.au=Gireesh%2C+E.Dharmaraj%3BPlenz%2C+D&rft.aulast=Gireesh&rft.aufirst=E.Dharmaraj&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rolipram Rescues Spatial Memory Deficits in Galanin - Overexpressing Transgenic Mice T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39889529; 4134838 JF - 35th Annual Meeting of the Society for Neuroscience AU - Rustay, N R AU - Crawley, J N Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Mice KW - Galanin KW - Spatial memory KW - Rolipram KW - Transgenic mice KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39889529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Rolipram+Rescues+Spatial+Memory+Deficits+in+Galanin+-+Overexpressing+Transgenic+Mice&rft.au=Rustay%2C+N+R%3BCrawley%2C+J+N&rft.aulast=Rustay&rft.aufirst=N&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Does Superior Colliculus Stimulation Directly Shift Attention or Produce a Visual Cue? T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39889504; 4122379 JF - 35th Annual Meeting of the Society for Neuroscience AU - Cavanaugh, J AU - Alvarez, B D AU - Wurtz, R H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Attention KW - Superior colliculus KW - Visual stimuli KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39889504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Does+Superior+Colliculus+Stimulation+Directly+Shift+Attention+or+Produce+a+Visual+Cue%3F&rft.au=Cavanaugh%2C+J%3BAlvarez%2C+B+D%3BWurtz%2C+R+H&rft.aulast=Cavanaugh&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High - and Low - Frequency Stimuli Preferentially Activate Different Steps in the ERK Cascade T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39889118; 4134206 JF - 35th Annual Meeting of the Society for Neuroscience AU - Hongpaisan, J AU - Winters, C A AU - Andrews, S B Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Extracellular signal-regulated kinase KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39889118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=High+-+and+Low+-+Frequency+Stimuli+Preferentially+Activate+Different+Steps+in+the+ERK+Cascade&rft.au=Hongpaisan%2C+J%3BWinters%2C+C+A%3BAndrews%2C+S+B&rft.aulast=Hongpaisan&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification and Characterization of pA134, a Novel Squid Axonal mrna and its Cognate Protein in the Mammalian Brain T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39888892; 4134175 JF - 35th Annual Meeting of the Society for Neuroscience AU - Mameza, M G AU - Lockard, J AU - Gioio, A E AU - Hillefors, M AU - Lavino, Z.Scotto AU - Kaplan, B B Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Brain KW - MRNA KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39888892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Identification+and+Characterization+of+pA134%2C+a+Novel+Squid+Axonal+mrna+and+its+Cognate+Protein+in+the+Mammalian+Brain&rft.au=Mameza%2C+M+G%3BLockard%2C+J%3BGioio%2C+A+E%3BHillefors%2C+M%3BLavino%2C+Z.Scotto%3BKaplan%2C+B+B&rft.aulast=Mameza&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lateralized Conceptual Processing in the Perirhinal Cortex During Object Naming Revealed using High - Resolution Fmri. T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39888286; 4119250 JF - 35th Annual Meeting of the Society for Neuroscience AU - Bellgowan, P.S.F. AU - Raymundo, N AU - Bodurka, J AU - Martin, A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Functional magnetic resonance imaging KW - Cortex KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39888286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Lateralized+Conceptual+Processing+in+the+Perirhinal+Cortex+During+Object+Naming+Revealed+using+High+-+Resolution+Fmri.&rft.au=Bellgowan%2C+P.S.F.%3BRaymundo%2C+N%3BBodurka%2C+J%3BMartin%2C+A&rft.aulast=Bellgowan&rft.aufirst=P.S.F.&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Disruption of mGluR8a - Mediated Calcium Channel Inhibition by Fluorophore - Asssisted Light Inactivation in Rat Sympathetic Neurons T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39888042; 4123821 JF - 35th Annual Meeting of the Society for Neuroscience AU - Guo, J AU - Chen, H AU - Puhl, H L AU - Ikeda, S R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Sympathetic nerves KW - Fluorophores KW - Calcium channels KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39888042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Disruption+of+mGluR8a+-+Mediated+Calcium+Channel+Inhibition+by+Fluorophore+-+Asssisted+Light+Inactivation+in+Rat+Sympathetic+Neurons&rft.au=Guo%2C+J%3BChen%2C+H%3BPuhl%2C+H+L%3BIkeda%2C+S+R&rft.aulast=Guo&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interaction of the Hereditary Spastic Paraplegia ( SPG20 ) Protein Spartin with Eps15 T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39887736; 4135083 JF - 35th Annual Meeting of the Society for Neuroscience AU - Bakowska, J C AU - Russell, J W AU - Pendleton, J AU - Blackstone, C Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Spastic paraplegia KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39887736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Interaction+of+the+Hereditary+Spastic+Paraplegia+%28+SPG20+%29+Protein+Spartin+with+Eps15&rft.au=Bakowska%2C+J+C%3BRussell%2C+J+W%3BPendleton%2C+J%3BBlackstone%2C+C&rft.aulast=Bakowska&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Centrally Acting Angiotensin II AT@@d1@ Receptor Antagonist Prevents the Isolation Stress - Induced Decrease in Cortical CRH@@d1@ Receptor and Benzodiazepine Binding T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39887473; 4122787 JF - 35th Annual Meeting of the Society for Neuroscience AU - Pavel, J AU - Armando, I AU - Bregonzio, C AU - Juorio, A AU - Macova, M AU - Saavedra, J M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Stress KW - Benzodiazepine KW - Angiotensin II KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39887473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=A+Centrally+Acting+Angiotensin+II+AT%40%40d1%40+Receptor+Antagonist+Prevents+the+Isolation+Stress+-+Induced+Decrease+in+Cortical+CRH%40%40d1%40+Receptor+and+Benzodiazepine+Binding&rft.au=Pavel%2C+J%3BArmando%2C+I%3BBregonzio%2C+C%3BJuorio%2C+A%3BMacova%2C+M%3BSaavedra%2C+J+M&rft.aulast=Pavel&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - BDNF Gene Expression is Differentially Regulated by Postsynaptic Activity Correlated and Uncorrelated with Synaptic Input to CA1 Hippocampal Neurons T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39886367; 4127336 JF - 35th Annual Meeting of the Society for Neuroscience AU - Fields, R D AU - Cohen, J E AU - Lee, P R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Brain-derived neurotrophic factor KW - Hippocampus KW - Neurons KW - Gene expression KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39886367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=BDNF+Gene+Expression+is+Differentially+Regulated+by+Postsynaptic+Activity+Correlated+and+Uncorrelated+with+Synaptic+Input+to+CA1+Hippocampal+Neurons&rft.au=Fields%2C+R+D%3BCohen%2C+J+E%3BLee%2C+P+R&rft.aulast=Fields&rft.aufirst=R&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Different Spatiotemporal Profiles in the Gamma Band for Processing Fearful, Angry, and Neutral Expressions: An MEG Study T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39886238; 4120036 DE: JF - 35th Annual Meeting of the Society for Neuroscience AU - Luo, Q AU - Holroyd, T AU - Jones, M AU - Hendler, T AU - Blair, J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39886238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Different+Spatiotemporal+Profiles+in+the+Gamma+Band+for+Processing+Fearful%2C+Angry%2C+and+Neutral+Expressions%3A+An+MEG+Study&rft.au=Luo%2C+Q%3BHolroyd%2C+T%3BJones%2C+M%3BHendler%2C+T%3BBlair%2C+J&rft.aulast=Luo&rft.aufirst=Q&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Pheromone Androstenol ( 5a - androst - 16 - en - 3a - ol ) is a Neurosteroid T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39884327; 4123793 JF - 35th Annual Meeting of the Society for Neuroscience AU - Kaminski, R M AU - Marini, H AU - Ortinski, P I AU - Yonekawa, W AU - Vicini, S AU - Rogawski, M A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Pheromones KW - Neurosteroids KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39884327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Pheromone+Androstenol+%28+5a+-+androst+-+16+-+en+-+3a+-+ol+%29+is+a+Neurosteroid&rft.au=Kaminski%2C+R+M%3BMarini%2C+H%3BOrtinski%2C+P+I%3BYonekawa%2C+W%3BVicini%2C+S%3BRogawski%2C+M+A&rft.aulast=Kaminski&rft.aufirst=R&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Medial Temporal Removals Preserve Projections From Auditory Belt and Parabelt to Frontal Cortex T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39883802; 4120854 JF - 35th Annual Meeting of the Society for Neuroscience AU - Munoz, M AU - Saunders, R C AU - Mishkin, M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Cortex (temporal) KW - Cortex (frontal) KW - Cortex (auditory) KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39883802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Medial+Temporal+Removals+Preserve+Projections+From+Auditory+Belt+and+Parabelt+to+Frontal+Cortex&rft.au=Munoz%2C+M%3BSaunders%2C+R+C%3BMishkin%2C+M&rft.aulast=Munoz&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Developmental Changes in Visual Selective Attention: Comparison of Children with Healthy Adults T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39883046; 4132933 JF - 35th Annual Meeting of the Society for Neuroscience AU - Friedman-Hill, S R AU - Gex, S E AU - Towbin, K E AU - Pine, D S AU - Leibenluft, E AU - Ungerleider, L G Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Children KW - Attention KW - Visual perception KW - Developmental stages KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39883046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Developmental+Changes+in+Visual+Selective+Attention%3A+Comparison+of+Children+with+Healthy+Adults&rft.au=Friedman-Hill%2C+S+R%3BGex%2C+S+E%3BTowbin%2C+K+E%3BPine%2C+D+S%3BLeibenluft%2C+E%3BUngerleider%2C+L+G&rft.aulast=Friedman-Hill&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activation in the Premotor Cortex During Perceiving Successive Stimuli With or Without Explicit Counting T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39882990; 4132914 JF - 35th Annual Meeting of the Society for Neuroscience AU - Kansaku, K AU - Grillon, M AU - Johnson, A AU - Sadato, N AU - Hallett, M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Enumeration KW - Cortex (premotor) KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39882990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Activation+in+the+Premotor+Cortex+During+Perceiving+Successive+Stimuli+With+or+Without+Explicit+Counting&rft.au=Kansaku%2C+K%3BGrillon%2C+M%3BJohnson%2C+A%3BSadato%2C+N%3BHallett%2C+M&rft.aulast=Kansaku&rft.aufirst=K&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a "Split Transcription Factor" System for Refined Spatial Manipulation of Neuronal Activity in Drosophila T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39882818; 4123528 JF - 35th Annual Meeting of the Society for Neuroscience AU - Luan, H AU - Marsh, J AU - White, B H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Transcription factors KW - Drosophila KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39882818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Development+of+a+%22Split+Transcription+Factor%22+System+for+Refined+Spatial+Manipulation+of+Neuronal+Activity+in+Drosophila&rft.au=Luan%2C+H%3BMarsh%2C+J%3BWhite%2C+B+H&rft.aulast=Luan&rft.aufirst=H&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Antipsychotics on Neural Activation During Reward Anticipation in Schizophrenia T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39882815; 4129776 JF - 35th Annual Meeting of the Society for Neuroscience AU - Wint, D AU - Koch, P AU - Dreher, J AU - Furman, D AU - Kohn, P AU - Egan, M AU - Weinberger, D AU - Berman, K F Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Neuroleptics KW - Schizophrenia KW - Reinforcement KW - Mental disorders KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39882815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effect+of+Antipsychotics+on+Neural+Activation+During+Reward+Anticipation+in+Schizophrenia&rft.au=Wint%2C+D%3BKoch%2C+P%3BDreher%2C+J%3BFurman%2C+D%3BKohn%2C+P%3BEgan%2C+M%3BWeinberger%2C+D%3BBerman%2C+K+F&rft.aulast=Wint&rft.aufirst=D&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Percept - Related Fluctuations of MT Local Field Potentials T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39882314; 4127540 DE: JF - 35th Annual Meeting of the Society for Neuroscience AU - Maier, A V AU - Logothetis, N K AU - Leopold, D A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39882314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Percept+-+Related+Fluctuations+of+MT+Local+Field+Potentials&rft.au=Maier%2C+A+V%3BLogothetis%2C+N+K%3BLeopold%2C+D+A&rft.aulast=Maier&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Negative Reinforcers Activates the Neural Reward Circuitry T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39882252; 4120997 JF - 35th Annual Meeting of the Society for Neuroscience AU - Martin-Soelch, C AU - Herdener, M AU - Kandzia, W AU - Scheffler, K AU - Seifritz, E Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Reinforcement KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39882252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Negative+Reinforcers+Activates+the+Neural+Reward+Circuitry&rft.au=Martin-Soelch%2C+C%3BHerdener%2C+M%3BKandzia%2C+W%3BScheffler%2C+K%3BSeifritz%2C+E&rft.aulast=Martin-Soelch&rft.aufirst=C&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prefrontal Mechanisms for Abstract Response Strategies T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39882246; 4120862 DE: JF - 35th Annual Meeting of the Society for Neuroscience AU - Genovesio, A AU - Brasted, P J AU - Mitz, A R AU - Wise, S P Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39882246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Prefrontal+Mechanisms+for+Abstract+Response+Strategies&rft.au=Genovesio%2C+A%3BBrasted%2C+P+J%3BMitz%2C+A+R%3BWise%2C+S+P&rft.aulast=Genovesio&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Investigating the Neural Basis of Psychophysiological Interactions in fMRI T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39882155; 4120835 JF - 35th Annual Meeting of the Society for Neuroscience AU - Kim, J AU - Horwitz, B Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Functional magnetic resonance imaging KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39882155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Investigating+the+Neural+Basis+of+Psychophysiological+Interactions+in+fMRI&rft.au=Kim%2C+J%3BHorwitz%2C+B&rft.aulast=Kim&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Depletion of Chromogranin A by Antisense RNAs Leads to Abnormal Chromaffin Granule Biogenesis in Transgenic Mice T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39882016; 4134135 JF - 35th Annual Meeting of the Society for Neuroscience AU - Kim, T AU - Zhang, C F AU - Sun, Z AU - Wu, H. AU - Loh, Y P Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Mice KW - Antisense RNA KW - Chromogranins KW - Evolution KW - Transgenic mice KW - Chromaffin granules KW - Biogenesis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39882016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Depletion+of+Chromogranin+A+by+Antisense+RNAs+Leads+to+Abnormal+Chromaffin+Granule+Biogenesis+in+Transgenic+Mice&rft.au=Kim%2C+T%3BZhang%2C+C+F%3BSun%2C+Z%3BWu%2C+H.%3BLoh%2C+Y+P&rft.aulast=Kim&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Calcium Influx Through Postsynaptic AMPA Receptors Elicits GABA Release at a Reciprocal Synapse of Rat Retina T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39881327; 4127271 JF - 35th Annual Meeting of the Society for Neuroscience AU - Chavez, A E AU - Diamond, J S Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Retina KW - ^a-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors KW - Calcium influx KW - Synapses KW - ^g-Aminobutyric acid KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39881327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Calcium+Influx+Through+Postsynaptic+AMPA+Receptors+Elicits+GABA+Release+at+a+Reciprocal+Synapse+of+Rat+Retina&rft.au=Chavez%2C+A+E%3BDiamond%2C+J+S&rft.aulast=Chavez&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Myelin - Associated Glycoprotein - Activated Signaling in Oligodendrocytes T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39881175; 4134347 JF - 35th Annual Meeting of the Society for Neuroscience AU - Cheng, S AU - Quarles, R H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Signal transduction KW - Myelin KW - Glycoproteins KW - Oligodendrocytes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39881175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Myelin+-+Associated+Glycoprotein+-+Activated+Signaling+in+Oligodendrocytes&rft.au=Cheng%2C+S%3BQuarles%2C+R+H&rft.aulast=Cheng&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dopamine - - Glutamate Interaction Induces Neuronal Avalanches in Superficial Layers of Rat Prefrontal Cortex T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39880894; 4134285 JF - 35th Annual Meeting of the Society for Neuroscience AU - Stewart, C V AU - Gerfen, C AU - Plenz, D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Avalanches KW - Glutamic acid KW - Cortex (prefrontal) KW - Dopamine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39880894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Dopamine+-+-+Glutamate+Interaction+Induces+Neuronal+Avalanches+in+Superficial+Layers+of+Rat+Prefrontal+Cortex&rft.au=Stewart%2C+C+V%3BGerfen%2C+C%3BPlenz%2C+D&rft.aulast=Stewart&rft.aufirst=C&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neural Correlates of Regional Electroencephalogram Power Change T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39880809; 4134255 JF - 35th Annual Meeting of the Society for Neuroscience AU - Oishi, N AU - Mima, T AU - Ishii, K AU - Bushara, K O AU - Hiraoka, T AU - Ueki, Y AU - Fukuyama, H AU - Hallett, M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - EEG KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39880809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neural+Correlates+of+Regional+Electroencephalogram+Power+Change&rft.au=Oishi%2C+N%3BMima%2C+T%3BIshii%2C+K%3BBushara%2C+K+O%3BHiraoka%2C+T%3BUeki%2C+Y%3BFukuyama%2C+H%3BHallett%2C+M&rft.aulast=Oishi&rft.aufirst=N&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Kinetic and Metabolic Evaluation of New PET Ligands for Peripheral Benzodiazepine Receptors T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39880363; 4126872 JF - 35th Annual Meeting of the Society for Neuroscience AU - Imaizumi, M AU - Briard, E AU - Zoghbi, S S AU - Hong, J AU - Shah, J AU - Musachio, J L AU - Pike, V W AU - Innis, R B AU - Fujita, M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Kinetics KW - Benzodiazepine receptors KW - Ligands KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39880363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Kinetic+and+Metabolic+Evaluation+of+New+PET+Ligands+for+Peripheral+Benzodiazepine+Receptors&rft.au=Imaizumi%2C+M%3BBriard%2C+E%3BZoghbi%2C+S+S%3BHong%2C+J%3BShah%2C+J%3BMusachio%2C+J+L%3BPike%2C+V+W%3BInnis%2C+R+B%3BFujita%2C+M&rft.aulast=Imaizumi&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Further Evidence Supporting Glycogen Synthase Kinase - 3 and b - Catenin as Mediators of the Behavioral Effects of Lithium T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39880289; 4121780 JF - 35th Annual Meeting of the Society for Neuroscience AU - Gould, T D AU - Einat, H AU - Picchini, A M AU - Bhat, R AU - Eberthart, C G AU - Schloesser, R J AU - Manji, H K Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Lithium KW - Catenin KW - Glycogen synthase kinase 3 KW - Glycogen KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39880289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Further+Evidence+Supporting+Glycogen+Synthase+Kinase+-+3+and+b+-+Catenin+as+Mediators+of+the+Behavioral+Effects+of+Lithium&rft.au=Gould%2C+T+D%3BEinat%2C+H%3BPicchini%2C+A+M%3BBhat%2C+R%3BEberthart%2C+C+G%3BSchloesser%2C+R+J%3BManji%2C+H+K&rft.aulast=Gould&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Decision - Making Processes During Potential Reward and Punishment: An fMRI Study T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39880285; 4133217 JF - 35th Annual Meeting of the Society for Neuroscience AU - Hardin, M G AU - Pine, D S AU - Ernst, M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Reinforcement KW - Punishment KW - Functional magnetic resonance imaging KW - Decision making KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39880285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Decision+-+Making+Processes+During+Potential+Reward+and+Punishment%3A+An+fMRI+Study&rft.au=Hardin%2C+M+G%3BPine%2C+D+S%3BErnst%2C+M&rft.aulast=Hardin&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nucleotide Sequence Variation Within the Human Tyrosine Kinase B Neurotrophin Receptor Gene ( NTRK2 ) is Associated with Alcohol Dependence and Alcohol Abuse T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39879960; 4133681 JF - 35th Annual Meeting of the Society for Neuroscience AU - Xu, K. AU - Anderson, T R AU - Neyer, K M AU - Lamparella, N AU - Jenkins, G AU - Zhou, Z AU - Lipsky, R H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Alcohols KW - Protein-tyrosine kinase KW - Neurotrophin receptors KW - Drug abuse KW - Drug dependence KW - Nucleotide sequence KW - Tyrosine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39879960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Nucleotide+Sequence+Variation+Within+the+Human+Tyrosine+Kinase+B+Neurotrophin+Receptor+Gene+%28+NTRK2+%29+is+Associated+with+Alcohol+Dependence+and+Alcohol+Abuse&rft.au=Xu%2C+K.%3BAnderson%2C+T+R%3BNeyer%2C+K+M%3BLamparella%2C+N%3BJenkins%2C+G%3BZhou%2C+Z%3BLipsky%2C+R+H&rft.aulast=Xu&rft.aufirst=K.&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Two Critical Stages of Late - phase Long - term Potentiation (L - LTP) Mediated by BDNF with Distinct Mechanisms T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39879565; 4130800 JF - 35th Annual Meeting of the Society for Neuroscience AU - Pang, P T AU - Yung, W H AU - Lu, B. Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Long-term potentiation KW - Brain-derived neurotrophic factor KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39879565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Two+Critical+Stages+of+Late+-+phase+Long+-+term+Potentiation+%28L+-+LTP%29+Mediated+by+BDNF+with+Distinct+Mechanisms&rft.au=Pang%2C+P+T%3BYung%2C+W+H%3BLu%2C+B.&rft.aulast=Pang&rft.aufirst=P&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distribution of Scaffolding Molecules at the Postsynaptic Density T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39878913; 4119712 JF - 35th Annual Meeting of the Society for Neuroscience AU - DeGiorgis, J A AU - Dosemeci, A AU - Reese, T S Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Postsynaptic density KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39878913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Distribution+of+Scaffolding+Molecules+at+the+Postsynaptic+Density&rft.au=DeGiorgis%2C+J+A%3BDosemeci%2C+A%3BReese%2C+T+S&rft.aulast=DeGiorgis&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single Nucleotide Polymorphisms ( SNPs ) in NRG1 Affect Nicotinic Acetylcholine Receptor ( nAChR ) a7 Subunit Expression T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39878207; 4130104 JF - 35th Annual Meeting of the Society for Neuroscience AU - Mathew, S V AU - Hyde, T M AU - Lipska, B K AU - Vakkalanka, R AU - Straub, R E AU - Weinberger, D R AU - Kleinman, J E Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Acetylcholine receptors (nicotinic) KW - Single-nucleotide polymorphism KW - Neurotransmitters KW - Nucleotides KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39878207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Single+Nucleotide+Polymorphisms+%28+SNPs+%29+in+NRG1+Affect+Nicotinic+Acetylcholine+Receptor+%28+nAChR+%29+a7+Subunit+Expression&rft.au=Mathew%2C+S+V%3BHyde%2C+T+M%3BLipska%2C+B+K%3BVakkalanka%2C+R%3BStraub%2C+R+E%3BWeinberger%2C+D+R%3BKleinman%2C+J+E&rft.aulast=Mathew&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dysregulation of the Brain Stress System and Propensity to Relapse in Genetically Selected Alcohol Preferring msP Rats T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39877938; 4130173 JF - 35th Annual Meeting of the Society for Neuroscience AU - Hansson, A C AU - Cippitelli, A AU - Sommer, W H AU - Fideli, A AU - Massi, M AU - Heilig, M AU - Ciccocioppo, R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Alcohols KW - Stress KW - Brain KW - Rats KW - Ethanol KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39877938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Dysregulation+of+the+Brain+Stress+System+and+Propensity+to+Relapse+in+Genetically+Selected+Alcohol+Preferring+msP+Rats&rft.au=Hansson%2C+A+C%3BCippitelli%2C+A%3BSommer%2C+W+H%3BFideli%2C+A%3BMassi%2C+M%3BHeilig%2C+M%3BCiccocioppo%2C+R&rft.aulast=Hansson&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Function of Alternatively Spliced Nonmuscle Myosin II - B Isoforms in Mouse Brain Development T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39877816; 4130444 JF - 35th Annual Meeting of the Society for Neuroscience AU - Ma, X. AU - Kawamoto, S AU - Bridgman, P C AU - Uribe, J A AU - Adelstein, R S Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Brain KW - Myosin KW - Alternative splicing KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39877816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Function+of+Alternatively+Spliced+Nonmuscle+Myosin+II+-+B+Isoforms+in+Mouse+Brain+Development&rft.au=Ma%2C+X.%3BKawamoto%2C+S%3BBridgman%2C+P+C%3BUribe%2C+J+A%3BAdelstein%2C+R+S&rft.aulast=Ma&rft.aufirst=X.&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vanilloid - Evoked Calcium Responses from Embryonic Cortical Neurons in Primary Culture T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39877240; 4125788 JF - 35th Annual Meeting of the Society for Neuroscience AU - Csermely, T AU - Mitchell, K AU - Keller, J AU - Karai, L AU - Iadarola, M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Calcium KW - Embryos KW - Cortex KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39877240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Vanilloid+-+Evoked+Calcium+Responses+from+Embryonic+Cortical+Neurons+in+Primary+Culture&rft.au=Csermely%2C+T%3BMitchell%2C+K%3BKeller%2C+J%3BKarai%2C+L%3BIadarola%2C+M&rft.aulast=Csermely&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Shifting Visual Receptive Fields in the Frontal Eye Field: Do they Use Corollary Discharge from the Thalamus? T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39877221; 4119673 JF - 35th Annual Meeting of the Society for Neuroscience AU - Sommer, M A AU - Wurtz, R H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Eye KW - Thalamus KW - Receptive field KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39877221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Shifting+Visual+Receptive+Fields+in+the+Frontal+Eye+Field%3A+Do+they+Use+Corollary+Discharge+from+the+Thalamus%3F&rft.au=Sommer%2C+M+A%3BWurtz%2C+R+H&rft.aulast=Sommer&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activation of Dopamine D@@d1@, Not D@@d5@, Receptors Facilitates Extinction of Fear Memories in Mice T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39876816; 4128065 JF - 35th Annual Meeting of the Society for Neuroscience AU - Izquierdo, A AU - Cabrera, D M AU - Sibley, D R AU - Holmes, A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Mice KW - Dopamine D5 receptors KW - Extinction KW - Fear KW - Dopamine D1 receptors KW - Memory KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39876816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Activation+of+Dopamine+D%40%40d1%40%2C+Not+D%40%40d5%40%2C+Receptors+Facilitates+Extinction+of+Fear+Memories+in+Mice&rft.au=Izquierdo%2C+A%3BCabrera%2C+D+M%3BSibley%2C+D+R%3BHolmes%2C+A&rft.aulast=Izquierdo&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Additive Effects of Endogenous Cannabinoid Anandamide and Halothane on a7 - Nicotinic Acetylcholine Receptor - Mediated Responses in Xenopus Oocytes T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39876697; 4133972 JF - 35th Annual Meeting of the Society for Neuroscience AU - Zhang, L AU - Oz, M. AU - Jackson, S N AU - Woods, A S AU - Morales, M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Additives KW - Anandamide KW - Oocytes KW - Acetylcholine receptors (nicotinic) KW - Halothane KW - Neurotransmitters KW - Amphibiotic species KW - Xenopus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39876697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Additive+Effects+of+Endogenous+Cannabinoid+Anandamide+and+Halothane+on+a7+-+Nicotinic+Acetylcholine+Receptor+-+Mediated+Responses+in+Xenopus+Oocytes&rft.au=Zhang%2C+L%3BOz%2C+M.%3BJackson%2C+S+N%3BWoods%2C+A+S%3BMorales%2C+M&rft.aulast=Zhang&rft.aufirst=L&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Patterns of NMDAR 2C Subunit Expression Revealed Using b - Gal Knock - in Mice T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39876550; 4127134 JF - 35th Annual Meeting of the Society for Neuroscience AU - Karavanova, I AU - Vasudevan, K AU - Buonanno, A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Mice KW - Glutamic acid receptors KW - N-Methyl-D-aspartic acid receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39876550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Novel+Patterns+of+NMDAR+2C+Subunit+Expression+Revealed+Using+b+-+Gal+Knock+-+in+Mice&rft.au=Karavanova%2C+I%3BVasudevan%2C+K%3BBuonanno%2C+A&rft.aulast=Karavanova&rft.aufirst=I&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activity - Dependent Interaction between Axons and Astrocytes Promotes CNS Myelination T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39876080; 4124081 JF - 35th Annual Meeting of the Society for Neuroscience AU - Ishibashi, T AU - Lee, P R AU - Fields, R D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Central nervous system KW - Myelination KW - Astrocytes KW - Axons KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39876080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Activity+-+Dependent+Interaction+between+Axons+and+Astrocytes+Promotes+CNS+Myelination&rft.au=Ishibashi%2C+T%3BLee%2C+P+R%3BFields%2C+R+D&rft.aulast=Ishibashi&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vasopressin Mediates Pituitary Mitogenesis but not Increases in the Number of ACTH Containing Corticotrophs T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39875864; 4129420 JF - 35th Annual Meeting of the Society for Neuroscience AU - Subburaju, S AU - Zeise, M AU - Aguilera, G Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Adrenocorticotropic hormone KW - Pituitary KW - Vasopressin KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39875864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Vasopressin+Mediates+Pituitary+Mitogenesis+but+not+Increases+in+the+Number+of+ACTH+Containing+Corticotrophs&rft.au=Subburaju%2C+S%3BZeise%2C+M%3BAguilera%2C+G&rft.aulast=Subburaju&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Imaging the Effects of Levodopa on Motor Memory Formation with 11 - C - Raclopride PET in Healthy Elderly Subjects T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39874856; 4118998 JF - 35th Annual Meeting of the Society for Neuroscience AU - Floel, A AU - Garraux, G AU - Breitenstein, C AU - Herscovitch, P AU - Knecht, S AU - Cohen, L G Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Elderly KW - Levodopa KW - Raclopride KW - Geriatrics KW - Memory KW - Imaging techniques KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39874856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Imaging+the+Effects+of+Levodopa+on+Motor+Memory+Formation+with+11+-+C+-+Raclopride+PET+in+Healthy+Elderly+Subjects&rft.au=Floel%2C+A%3BGarraux%2C+G%3BBreitenstein%2C+C%3BHerscovitch%2C+P%3BKnecht%2C+S%3BCohen%2C+L+G&rft.aulast=Floel&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Modeling Study of the Human P2Y@@d2@ Receptor Agonists T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39873747; 4125435 JF - 35th Annual Meeting of the Society for Neuroscience AU - Ivanov, A A AU - Costanzi, S AU - Jacobson, K A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Purine P2Y receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39873747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Molecular+Modeling+Study+of+the+Human+P2Y%40%40d2%40+Receptor+Agonists&rft.au=Ivanov%2C+A+A%3BCostanzi%2C+S%3BJacobson%2C+K+A&rft.aulast=Ivanov&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Time - Course Changes of Dopamine D@@d2@ and CB1 Cannabinoid Receptors During Cocaine Self - Administration T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39872810; 4128482 JF - 35th Annual Meeting of the Society for Neuroscience AU - Thanos, P K AU - Soria, L AU - Michaelides, M E AU - Piyis, Y K AU - Pappas, G P AU - Maldonado, R AU - Valverde, O AU - Volkow, N D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Cocaine KW - Cannabinoid CB1 receptors KW - Dopamine D2 receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39872810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Time+-+Course+Changes+of+Dopamine+D%40%40d2%40+and+CB1+Cannabinoid+Receptors+During+Cocaine+Self+-+Administration&rft.au=Thanos%2C+P+K%3BSoria%2C+L%3BMichaelides%2C+M+E%3BPiyis%2C+Y+K%3BPappas%2C+G+P%3BMaldonado%2C+R%3BValverde%2C+O%3BVolkow%2C+N+D&rft.aulast=Thanos&rft.aufirst=P&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo and In Vitro Measurement of Brain Phosphodiesterase 4 in Rats after Antidepressant Treatment T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39872242; 4119892 JF - 35th Annual Meeting of the Society for Neuroscience AU - Fujita, M AU - Imaizumi, M AU - D'Sa, C AU - Zoghbi, S S AU - Crescenzo, M S AU - Hong, J AU - Musachio, J L AU - Gee, A D AU - Seidel, J AU - Green, M V AU - Pike, V W AU - Duman, R S AU - Innis, R B Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Antidepressants KW - Brain KW - Rats KW - Phosphodiesterase IV KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39872242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=In+Vivo+and+In+Vitro+Measurement+of+Brain+Phosphodiesterase+4+in+Rats+after+Antidepressant+Treatment&rft.au=Fujita%2C+M%3BImaizumi%2C+M%3BD%27Sa%2C+C%3BZoghbi%2C+S+S%3BCrescenzo%2C+M+S%3BHong%2C+J%3BMusachio%2C+J+L%3BGee%2C+A+D%3BSeidel%2C+J%3BGreen%2C+M+V%3BPike%2C+V+W%3BDuman%2C+R+S%3BInnis%2C+R+B&rft.aulast=Fujita&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sulcal Morphometry in Williams Syndrome T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39870781; 4126098 JF - 35th Annual Meeting of the Society for Neuroscience AU - Kippenhan, J S AU - Meyer-Lindenberg, A AU - Olsen, R K AU - Mervis, C B AU - Morris, C A AU - Kohn, P D AU - Berman, K F Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Williams syndrome KW - Morphometry KW - Animal morphology KW - Symptoms KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39870781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Sulcal+Morphometry+in+Williams+Syndrome&rft.au=Kippenhan%2C+J+S%3BMeyer-Lindenberg%2C+A%3BOlsen%2C+R+K%3BMervis%2C+C+B%3BMorris%2C+C+A%3BKohn%2C+P+D%3BBerman%2C+K+F&rft.aulast=Kippenhan&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Shifting Visual Receptive Fields in the Frontal Eye Field: Do they Spread or do they Jump? T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39868971; 4119672 JF - 35th Annual Meeting of the Society for Neuroscience AU - Wurtz, R H AU - Sommer, M A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Eye KW - Receptive field KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39868971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Shifting+Visual+Receptive+Fields+in+the+Frontal+Eye+Field%3A+Do+they+Spread+or+do+they+Jump%3F&rft.au=Wurtz%2C+R+H%3BSommer%2C+M+A&rft.aulast=Wurtz&rft.aufirst=R&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Menstrual Cycle Phase Modulates the Reward System in Women T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39868730; 4121005 JF - 35th Annual Meeting of the Society for Neuroscience AU - Dreher, J AU - Schmidt, P AU - Kohn, P AU - Furman, D AU - Olsen, R AU - Koch, P AU - Rubinow, D AU - Berman, K Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Menstrual cycle KW - Reinforcement KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39868730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Menstrual+Cycle+Phase+Modulates+the+Reward+System+in+Women&rft.au=Dreher%2C+J%3BSchmidt%2C+P%3BKohn%2C+P%3BFurman%2C+D%3BOlsen%2C+R%3BKoch%2C+P%3BRubinow%2C+D%3BBerman%2C+K&rft.aulast=Dreher&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Respective Contributions of Two Negative Feedback Mechanisms in Neuronal Rhythms T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39867443; 4124004 JF - 35th Annual Meeting of the Society for Neuroscience AU - Tabak, J AU - Rinzel, J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Feedback KW - Rhythms KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39867443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Respective+Contributions+of+Two+Negative+Feedback+Mechanisms+in+Neuronal+Rhythms&rft.au=Tabak%2C+J%3BRinzel%2C+J&rft.aulast=Tabak&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Early Global Gene Responses to Distinct Activity Patterns T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39864047; 4125865 JF - 35th Annual Meeting of the Society for Neuroscience AU - Rana, Z A AU - Gundersen, K AU - Buonanno, A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Activity patterns KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39864047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Early+Global+Gene+Responses+to+Distinct+Activity+Patterns&rft.au=Rana%2C+Z+A%3BGundersen%2C+K%3BBuonanno%2C+A&rft.aulast=Rana&rft.aufirst=Z&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Discovery and Characterization of S100a8 and S100a9 in the Sensory Pathway System: Implications for Nociception T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39863598; 4125789 JF - 35th Annual Meeting of the Society for Neuroscience AU - Mitchell, K AU - Muhly, W T AU - Keller, J M AU - Yang, H T AU - Iadarola, M J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Pain perception KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39863598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Discovery+and+Characterization+of+S100a8+and+S100a9+in+the+Sensory+Pathway+System%3A+Implications+for+Nociception&rft.au=Mitchell%2C+K%3BMuhly%2C+W+T%3BKeller%2C+J+M%3BYang%2C+H+T%3BIadarola%2C+M+J&rft.aulast=Mitchell&rft.aufirst=K&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prefrontal Cortex Inefficiency During Working Memory in Unaffected Siblings of Patients with Schizophrenia T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39863074; 4128019 JF - 35th Annual Meeting of the Society for Neuroscience AU - Sust, S AU - Tan, H Y AU - Mattay, V S AU - Buckholtz, J AU - Egan, M F AU - Weinberger, D R AU - Callicott, J H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Schizophrenia KW - Mental disorders KW - Short term memory KW - Cortex (prefrontal) KW - Siblings KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39863074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Prefrontal+Cortex+Inefficiency+During+Working+Memory+in+Unaffected+Siblings+of+Patients+with+Schizophrenia&rft.au=Sust%2C+S%3BTan%2C+H+Y%3BMattay%2C+V+S%3BBuckholtz%2C+J%3BEgan%2C+M+F%3BWeinberger%2C+D+R%3BCallicott%2C+J+H&rft.aulast=Sust&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Saccade - Reward Contingency - Modulated Activity in the Primate Frontal Eye Field and Caudate Nucleus T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39862611; 4121011 JF - 35th Annual Meeting of the Society for Neuroscience AU - Ding, L AU - Hikosaka, O Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Eye KW - Reinforcement KW - Saccadic eye movements KW - Contingency KW - Caudate nucleus KW - Primates KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39862611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Comparison+of+Saccade+-+Reward+Contingency+-+Modulated+Activity+in+the+Primate+Frontal+Eye+Field+and+Caudate+Nucleus&rft.au=Ding%2C+L%3BHikosaka%2C+O&rft.aulast=Ding&rft.aufirst=L&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lithium Attenuates Smad3/4 Transcriptional Activity: Roles of GSK - 3 and cAMP/PKA Signaling T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39862039; 4119472 JF - 35th Annual Meeting of the Society for Neuroscience AU - Liang, M H AU - Chuang, D M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Lithium KW - Signal transduction KW - Protein kinase A KW - Transcription KW - Cyclic AMP KW - Smad3 protein KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39862039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Lithium+Attenuates+Smad3%2F4+Transcriptional+Activity%3A+Roles+of+GSK+-+3+and+cAMP%2FPKA+Signaling&rft.au=Liang%2C+M+H%3BChuang%2C+D+M&rft.aulast=Liang&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Parametric Modulation of Cortico - Limbic Structures by Interobject Desirability Distance: An fMRI Investigation T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39861963; 4118910 JF - 35th Annual Meeting of the Society for Neuroscience AU - Peschardt, K AU - Marsh, A AU - Morton, J AU - Drevets, W C AU - Blair, J R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Functional magnetic resonance imaging KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39861963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Parametric+Modulation+of+Cortico+-+Limbic+Structures+by+Interobject+Desirability+Distance%3A+An+fMRI+Investigation&rft.au=Peschardt%2C+K%3BMarsh%2C+A%3BMorton%2C+J%3BDrevets%2C+W+C%3BBlair%2C+J+R&rft.aulast=Peschardt&rft.aufirst=K&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Spatial Working Memory Development During Childhood and Adolescence T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39857182; 4128028 JF - 35th Annual Meeting of the Society for Neuroscience AU - Ordaz, S J AU - Wallace, G L AU - Greenstein, D K AU - Clasen, L S AU - Taylor, K N AU - Rosenthal, M A AU - Rose, A B AU - Giedd, J N Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Short term memory KW - Spatial memory KW - Adolescence KW - Children KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39857182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Spatial+Working+Memory+Development+During+Childhood+and+Adolescence&rft.au=Ordaz%2C+S+J%3BWallace%2C+G+L%3BGreenstein%2C+D+K%3BClasen%2C+L+S%3BTaylor%2C+K+N%3BRosenthal%2C+M+A%3BRose%2C+A+B%3BGiedd%2C+J+N&rft.aulast=Ordaz&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Selective Intracellular Signaling Pathway in the Anterior Cingulate Cortex Regulates Mania - related Behavior T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39842384; 4131896 JF - 35th Annual Meeting of the Society for Neuroscience AU - Creson, T K AU - Hao, Y AU - Engel, S AU - Yuan, P AU - Manji, H K AU - Chen, G Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Affective disorders KW - Intracellular signalling KW - Cortex (cingulate) KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39842384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=A+Selective+Intracellular+Signaling+Pathway+in+the+Anterior+Cingulate+Cortex+Regulates+Mania+-+related+Behavior&rft.au=Creson%2C+T+K%3BHao%2C+Y%3BEngel%2C+S%3BYuan%2C+P%3BManji%2C+H+K%3BChen%2C+G&rft.aulast=Creson&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Requirement of the Forebrain Rap1 for the Expression of Fear T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39840294; 4123051 JF - 35th Annual Meeting of the Society for Neuroscience AU - Vautier, F AU - Ito, W AU - Miah, C AU - Mirlas, B AU - Pan, B AU - Kandel, E R AU - Morozov, A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Rap1 protein KW - Forebrain KW - Fear KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39840294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Requirement+of+the+Forebrain+Rap1+for+the+Expression+of+Fear&rft.au=Vautier%2C+F%3BIto%2C+W%3BMiah%2C+C%3BMirlas%2C+B%3BPan%2C+B%3BKandel%2C+E+R%3BMorozov%2C+A&rft.aulast=Vautier&rft.aufirst=F&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationship of PSD Thickening and CaMKII Clustering to the Local Availability of a - CaMKII in Neurons T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39837264; 4130704 JF - 35th Annual Meeting of the Society for Neuroscience AU - Brightman, M W AU - Gallant, P AU - Dosemeci, A AU - Reese, T S AU - Tao-Cheng, J H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Ca@@u2+@/calmodulin-dependent protein kinase II KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39837264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Relationship+of+PSD+Thickening+and+CaMKII+Clustering+to+the+Local+Availability+of+a+-+CaMKII+in+Neurons&rft.au=Brightman%2C+M+W%3BGallant%2C+P%3BDosemeci%2C+A%3BReese%2C+T+S%3BTao-Cheng%2C+J+H&rft.aulast=Brightman&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Modulation of A1 Adenosine Receptor - Mediated Adenylyl Cyclase Signaling and Phospholipase C Signaling by PD 81,723 T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39837015; 4125424 JF - 35th Annual Meeting of the Society for Neuroscience AU - Gao, Z AU - Mamedova, L K AU - Jacobson, K A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Signal transduction KW - Adenylate cyclase KW - Adenosine receptors KW - Phospholipase C KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39837015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Differential+Modulation+of+A1+Adenosine+Receptor+-+Mediated+Adenylyl+Cyclase+Signaling+and+Phospholipase+C+Signaling+by+PD+81%2C723&rft.au=Gao%2C+Z%3BMamedova%2C+L+K%3BJacobson%2C+K+A&rft.aulast=Gao&rft.aufirst=Z&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Changes in Cortical Interneurons in BDNF Conditional Knock - Out Mice T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39836529; 4125362 JF - 35th Annual Meeting of the Society for Neuroscience AU - Paletzki, R F AU - Morozov, A Y Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Mice KW - Interneurons KW - Brain-derived neurotrophic factor KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39836529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Changes+in+Cortical+Interneurons+in+BDNF+Conditional+Knock+-+Out+Mice&rft.au=Paletzki%2C+R+F%3BMorozov%2C+A+Y&rft.aulast=Paletzki&rft.aufirst=R&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Pilot Study to Determine the Influence of Gastrocnemius Muscle on Knee Movement Sense T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39836279; 4132521 JF - 35th Annual Meeting of the Society for Neuroscience AU - Brindle, T J AU - Mizelle, J C AU - McLucas, J L AU - Stanhope, S J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Muscles KW - Knee KW - Gastrocnemius muscle KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39836279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=A+Pilot+Study+to+Determine+the+Influence+of+Gastrocnemius+Muscle+on+Knee+Movement+Sense&rft.au=Brindle%2C+T+J%3BMizelle%2C+J+C%3BMcLucas%2C+J+L%3BStanhope%2C+S+J&rft.aulast=Brindle&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of an ER - Retention Motif in an Intracellular Loop of the Kainate Receptor KA2 Subunit T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39835985; 4132387 JF - 35th Annual Meeting of the Society for Neuroscience AU - Nishimura, Y N AU - Tang, T.T.T. AU - Hurtado, D E AU - Isaac, J.T.R. AU - Roche, K W Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Glutamic acid receptors KW - Kainic acid receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39835985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Identification+of+an+ER+-+Retention+Motif+in+an+Intracellular+Loop+of+the+Kainate+Receptor+KA2+Subunit&rft.au=Nishimura%2C+Y+N%3BTang%2C+T.T.T.%3BHurtado%2C+D+E%3BIsaac%2C+J.T.R.%3BRoche%2C+K+W&rft.aulast=Nishimura&rft.aufirst=Y&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Heterogeneity of Dopamine Neuronal Responses in Monkeys during Visually Cued Reward Schedules T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39835136; 4134854 JF - 35th Annual Meeting of the Society for Neuroscience AU - Ravel, S AU - Richmond, B J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Reinforcement KW - Dopamine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39835136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Heterogeneity+of+Dopamine+Neuronal+Responses+in+Monkeys+during+Visually+Cued+Reward+Schedules&rft.au=Ravel%2C+S%3BRichmond%2C+B+J&rft.aulast=Ravel&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Anticipation of Waiting for Reward Degrades Performance in Visual Discrimination T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39835099; 4134851 JF - 35th Annual Meeting of the Society for Neuroscience AU - Minamimoto, T AU - Richmond, B J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Reinforcement KW - Visual discrimination KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39835099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Anticipation+of+Waiting+for+Reward+Degrades+Performance+in+Visual+Discrimination&rft.au=Minamimoto%2C+T%3BRichmond%2C+B+J&rft.aulast=Minamimoto&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Effects of Hydrocortisone on Amygdala Habituation to Emotional Facial Expressions: An fMRI Study T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39834972; 4122896 JF - 35th Annual Meeting of the Society for Neuroscience AU - Erickson, K AU - Wood, S E AU - Furey, M L AU - Nugent, A C AU - Mah, L AU - Schulkin, J AU - Drevets, W C Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Amygdala KW - Hydrocortisone KW - Functional magnetic resonance imaging KW - Emotions KW - Habituation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39834972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Differential+Effects+of+Hydrocortisone+on+Amygdala+Habituation+to+Emotional+Facial+Expressions%3A+An+fMRI+Study&rft.au=Erickson%2C+K%3BWood%2C+S+E%3BFurey%2C+M+L%3BNugent%2C+A+C%3BMah%2C+L%3BSchulkin%2C+J%3BDrevets%2C+W+C&rft.aulast=Erickson&rft.aufirst=K&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Resonance Energy Transfer Imaging of Stargazin - GluR1 Interactions in Living Cells T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39834710; 4133933 JF - 35th Annual Meeting of the Society for Neuroscience AU - Thaler, C AU - Honse, Y AU - Lovinger, D M AU - Vogel, S S Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Imaging techniques KW - CACNG2 protein KW - Glutamic acid receptors (ionotropic) KW - Calcium channels (voltage-gated) KW - Energy transfer KW - Resonance KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39834710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Resonance+Energy+Transfer+Imaging+of+Stargazin+-+GluR1+Interactions+in+Living+Cells&rft.au=Thaler%2C+C%3BHonse%2C+Y%3BLovinger%2C+D+M%3BVogel%2C+S+S&rft.aulast=Thaler&rft.aufirst=C&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cyclooxygenase ( COX ) - 2 is Required for Muscarinic Receptor - Mediated Brain Signaling Involving Phospholipase A2 Activation and Arachidonic Acid Release From Phospholipid T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39834523; 4132326 JF - 35th Annual Meeting of the Society for Neuroscience AU - Basselin, M AU - Villacreses, N E AU - Langerbach, R AU - Bell, J M AU - Rapoport, S I Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Brain KW - Arachidonic acid KW - Phospholipase A2 KW - Signal transduction KW - Prostaglandin-endoperoxide synthase KW - Phospholipids KW - Acetylcholine receptors (muscarinic) KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39834523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Cyclooxygenase+%28+COX+%29+-+2+is+Required+for+Muscarinic+Receptor+-+Mediated+Brain+Signaling+Involving+Phospholipase+A2+Activation+and+Arachidonic+Acid+Release+From+Phospholipid&rft.au=Basselin%2C+M%3BVillacreses%2C+N+E%3BLangerbach%2C+R%3BBell%2C+J+M%3BRapoport%2C+S+I&rft.aulast=Basselin&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Disulfide Crosslinking Studies with Cysteine - Substituted Mutant M3 Muscarinic Receptors: Identification of Agonist - Induced Conformational Changes that Occur Close to the Ligand Binding Pocket 149 G-Protein-Linked Receptors: Muscarinic T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39833376; 4122105 JF - 35th Annual Meeting of the Society for Neuroscience AU - Han, S AU - Hamdan, F F AU - Kim, S AU - Jacobson, K A AU - Bloodworth, L M AU - Li, B. AU - Wess, J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Mutants KW - Acetylcholine receptors (muscarinic) KW - Cysteine KW - Ligands KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39833376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Disulfide+Crosslinking+Studies+with+Cysteine+-+Substituted+Mutant+M3+Muscarinic+Receptors%3A+Identification+of+Agonist+-+Induced+Conformational+Changes+that+Occur+Close+to+the+Ligand+Binding+Pocket+149+G-Protein-Linked+Receptors%3A+Muscarinic&rft.au=Han%2C+S%3BHamdan%2C+F+F%3BKim%2C+S%3BJacobson%2C+K+A%3BBloodworth%2C+L+M%3BLi%2C+B.%3BWess%2C+J&rft.aulast=Han&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neurogranin and PKC Play a Critical Role in Modulating Affective States Seen in Bipolar Disorder T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39831784; 4131906 JF - 35th Annual Meeting of the Society for Neuroscience AU - Szabo, S T AU - Du, J. AU - Einat, H AU - Yuan, P AU - Wu, J. AU - Falke, C AU - Wei, Y AU - Zhou, R AU - Zhang, L AU - Huang, F AU - Huang, K AU - Manji, H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Emotional behavior KW - Bipolar disorder KW - Protein kinase C KW - Neurogranin KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39831784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neurogranin+and+PKC+Play+a+Critical+Role+in+Modulating+Affective+States+Seen+in+Bipolar+Disorder&rft.au=Szabo%2C+S+T%3BDu%2C+J.%3BEinat%2C+H%3BYuan%2C+P%3BWu%2C+J.%3BFalke%2C+C%3BWei%2C+Y%3BZhou%2C+R%3BZhang%2C+L%3BHuang%2C+F%3BHuang%2C+K%3BManji%2C+H&rft.aulast=Szabo&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Anticonvulsants Lamotrigine, Riluzole, and Valproate Differentially Regulate AMPA Receptor Trafficking: Relationship to Clinical Effects in Mood Disorders T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39831722; 4131904 JF - 35th Annual Meeting of the Society for Neuroscience AU - Wei, Y AU - Du, J. AU - Chen, Z AU - Falke, C AU - Suzuki, K AU - Zarate, C AU - Manji, H K Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Protein transport KW - ^a-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors KW - Mood KW - Lamotrigine KW - Anticonvulsants KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39831722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Anticonvulsants+Lamotrigine%2C+Riluzole%2C+and+Valproate+Differentially+Regulate+AMPA+Receptor+Trafficking%3A+Relationship+to+Clinical+Effects+in+Mood+Disorders&rft.au=Wei%2C+Y%3BDu%2C+J.%3BChen%2C+Z%3BFalke%2C+C%3BSuzuki%2C+K%3BZarate%2C+C%3BManji%2C+H+K&rft.aulast=Wei&rft.aufirst=Y&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Angiotensin II AT1 Receptor Antagonists on White Matter Lesions in the Rat Brain Induced by Cerebral Hypoperfusion T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39831580; 4131858 JF - 35th Annual Meeting of the Society for Neuroscience AU - Nishioku, T AU - Saavedra, J M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Brain KW - Lesions KW - Substantia alba KW - Angiotensin II KW - Antagonists KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39831580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effect+of+Angiotensin+II+AT1+Receptor+Antagonists+on+White+Matter+Lesions+in+the+Rat+Brain+Induced+by+Cerebral+Hypoperfusion&rft.au=Nishioku%2C+T%3BSaavedra%2C+J+M&rft.aulast=Nishioku&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of Substance Abuse in a Postmortem Sample of Schizophrenia T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39830880; 4128354 JF - 35th Annual Meeting of the Society for Neuroscience AU - Deep-Soboslay, A AU - Hyde, T M AU - Bigelow, L B AU - Herman, M M AU - Martin, C E AU - Kleinman, J E Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Substance abuse KW - Schizophrenia KW - Mental disorders KW - Drug abuse KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39830880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Role+of+Substance+Abuse+in+a+Postmortem+Sample+of+Schizophrenia&rft.au=Deep-Soboslay%2C+A%3BHyde%2C+T+M%3BBigelow%2C+L+B%3BHerman%2C+M+M%3BMartin%2C+C+E%3BKleinman%2C+J+E&rft.aulast=Deep-Soboslay&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Connectivity of Temporal Cortex during Categorization of Sounds T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39830652; 4134380 JF - 35th Annual Meeting of the Society for Neuroscience AU - Husain, F T AU - McKinney, C M AU - Horwitz, B Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Cortex (temporal) KW - Sound KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39830652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Functional+Connectivity+of+Temporal+Cortex+during+Categorization+of+Sounds&rft.au=Husain%2C+F+T%3BMcKinney%2C+C+M%3BHorwitz%2C+B&rft.aulast=Husain&rft.aufirst=F&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Expression of Glutathione S - Transferase a 4 in a Genetic Model of Alcoholism T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39829861; 4121348 JF - 35th Annual Meeting of the Society for Neuroscience AU - Bjork, K AU - Arlinde, C AU - Saarikoski, S T AU - Hyytia, P AU - Heilig, M AU - Sommer, W H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Glutathione KW - Drug abuse KW - Alcoholism KW - Models KW - Transferases KW - Coenzymes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39829861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Differential+Expression+of+Glutathione+S+-+Transferase+a+4+in+a+Genetic+Model+of+Alcoholism&rft.au=Bjork%2C+K%3BArlinde%2C+C%3BSaarikoski%2C+S+T%3BHyytia%2C+P%3BHeilig%2C+M%3BSommer%2C+W+H&rft.aulast=Bjork&rft.aufirst=K&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Neural Substrate of Face and House Perception During Passive Viewing in Williams Syndrome: Additional Evidence for Dorsal Stream Dysfunction T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39829784; 4130169 JF - 35th Annual Meeting of the Society for Neuroscience AU - Sarpal, D AU - Meyer-Lindenberg, A AU - Kohn, P D AU - Kippenhan, S AU - Mervis, C B AU - Morris, C A AU - Berman, K F Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Residential areas KW - Housing KW - Perception KW - Williams syndrome KW - Face KW - Streams KW - Pattern recognition KW - Symptoms KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39829784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Neural+Substrate+of+Face+and+House+Perception+During+Passive+Viewing+in+Williams+Syndrome%3A+Additional+Evidence+for+Dorsal+Stream+Dysfunction&rft.au=Sarpal%2C+D%3BMeyer-Lindenberg%2C+A%3BKohn%2C+P+D%3BKippenhan%2C+S%3BMervis%2C+C+B%3BMorris%2C+C+A%3BBerman%2C+K+F&rft.aulast=Sarpal&rft.aufirst=D&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Low Frequency Priming Facilitates Induction of LTP by Up - regulation of Endocannabinoid Signaling in the Hippocampus T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39829526; 4130565 JF - 35th Annual Meeting of the Society for Neuroscience AU - Zhu, P AU - Lovinger, D M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Signal transduction KW - Long-term potentiation KW - Cannabinoids KW - Hippocampus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39829526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Low+Frequency+Priming+Facilitates+Induction+of+LTP+by+Up+-+regulation+of+Endocannabinoid+Signaling+in+the+Hippocampus&rft.au=Zhu%2C+P%3BLovinger%2C+D+M&rft.aulast=Zhu&rft.aufirst=P&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Uncertainty, Likelihood, and Perceptual Decision Making T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39829262; 4120019 JF - 35th Annual Meeting of the Society for Neuroscience AU - Marrett, S AU - Ruff, D A AU - Heekeren, H R AU - Hwang, G C AU - Boemio, A AU - Bandettini, P A AU - Ungerleider, L G Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Decision making KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39829262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Uncertainty%2C+Likelihood%2C+and+Perceptual+Decision+Making&rft.au=Marrett%2C+S%3BRuff%2C+D+A%3BHeekeren%2C+H+R%3BHwang%2C+G+C%3BBoemio%2C+A%3BBandettini%2C+P+A%3BUngerleider%2C+L+G&rft.aulast=Marrett&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Velocity - Dependent Hypertonia of the Rectus Femoris Muscle in Patients with Cerebral Palsy T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39827469; 4135046 JF - 35th Annual Meeting of the Society for Neuroscience AU - Lebiedowska, M K AU - Burns, S R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Muscles KW - Velocity KW - Paralysis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39827469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Velocity+-+Dependent+Hypertonia+of+the+Rectus+Femoris+Muscle+in+Patients+with+Cerebral+Palsy&rft.au=Lebiedowska%2C+M+K%3BBurns%2C+S+R&rft.aulast=Lebiedowska&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rhythmic Electrical Activity in Developing GnRH - 1 Neurons T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39826665; 4131293 JF - 35th Annual Meeting of the Society for Neuroscience AU - Constantin, S AU - Duittoz, A AU - Wray, S Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Neurons KW - Gonadotropin-releasing hormone KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39826665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Rhythmic+Electrical+Activity+in+Developing+GnRH+-+1+Neurons&rft.au=Constantin%2C+S%3BDuittoz%2C+A%3BWray%2C+S&rft.aulast=Constantin&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cdk5 is Essential for Survival in Cortical Neurogenesis: A Study Based on Selective FACS Sorting of Neural Phenotypes T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39826355; 4128758 JF - 35th Annual Meeting of the Society for Neuroscience AU - Grant, P AU - Maric, D AU - Takahashi, S AU - Pareet, T AU - Barker, J L AU - Kulkarni, A AU - Pant, H C Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Neurogenesis KW - Cyclin-dependent kinase 5 KW - Survival KW - Phenotypes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39826355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Cdk5+is+Essential+for+Survival+in+Cortical+Neurogenesis%3A+A+Study+Based+on+Selective+FACS+Sorting+of+Neural+Phenotypes&rft.au=Grant%2C+P%3BMaric%2C+D%3BTakahashi%2C+S%3BPareet%2C+T%3BBarker%2C+J+L%3BKulkarni%2C+A%3BPant%2C+H+C&rft.aulast=Grant&rft.aufirst=P&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Scopolamine, Nicotine, and LY354740 on the 5 - choice Serial Reaction Time Task in the Common Marmoset Monkey T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39826026; 4129550 JF - 35th Annual Meeting of the Society for Neuroscience AU - Spinelli, S AU - Ballard, T M AU - Higley, J D AU - Higgins, G A AU - Feldon, J AU - Pryce, C R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Nicotine KW - Reaction time task KW - Scopolamine KW - Callithrix KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39826026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effects+of+Scopolamine%2C+Nicotine%2C+and+LY354740+on+the+5+-+choice+Serial+Reaction+Time+Task+in+the+Common+Marmoset+Monkey&rft.au=Spinelli%2C+S%3BBallard%2C+T+M%3BHigley%2C+J+D%3BHiggins%2C+G+A%3BFeldon%2C+J%3BPryce%2C+C+R&rft.aulast=Spinelli&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intranuclear Localization of Mre11, Rad50, and Nbs1 Proteins in Bergmann Glia, Purkinje Neurons, and Other Large Neurons of the Human Brain: Implications for the Pathogenesis of Ataxia - Telangiectasia - Like Disorder T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39825554; 4128546 JF - 35th Annual Meeting of the Society for Neuroscience AU - Brooks, P J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Brain KW - NBS1 protein KW - Ataxia KW - Glia KW - Neurons KW - Purkinje cells KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39825554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Intranuclear+Localization+of+Mre11%2C+Rad50%2C+and+Nbs1+Proteins+in+Bergmann+Glia%2C+Purkinje+Neurons%2C+and+Other+Large+Neurons+of+the+Human+Brain%3A+Implications+for+the+Pathogenesis+of+Ataxia+-+Telangiectasia+-+Like+Disorder&rft.au=Brooks%2C+P+J&rft.aulast=Brooks&rft.aufirst=P&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cyln2 - Deficient Mice Display Reduced Preference for Social Novelty: Relevance to Williams Syndrome T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39825514; 4128539 JF - 35th Annual Meeting of the Society for Neuroscience AU - Crawley, J N AU - Cohen, J J AU - Cuasay, K AU - Hill, J M AU - Sharer, K AU - Koretsky, A P AU - Galjart, N AU - Berman, K F Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Mice KW - Williams syndrome KW - Novelty KW - Symptoms KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39825514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Cyln2+-+Deficient+Mice+Display+Reduced+Preference+for+Social+Novelty%3A+Relevance+to+Williams+Syndrome&rft.au=Crawley%2C+J+N%3BCohen%2C+J+J%3BCuasay%2C+K%3BHill%2C+J+M%3BSharer%2C+K%3BKoretsky%2C+A+P%3BGaljart%2C+N%3BBerman%2C+K+F&rft.aulast=Crawley&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expansion of Monkey Superior Colliculus Movement Fields with Saccades to Moving Targets T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39825307; 4122408 JF - 35th Annual Meeting of the Society for Neuroscience AU - Port, N L AU - Wurtz, R H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Superior colliculus KW - Saccadic eye movements KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39825307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Expansion+of+Monkey+Superior+Colliculus+Movement+Fields+with+Saccades+to+Moving+Targets&rft.au=Port%2C+N+L%3BWurtz%2C+R+H&rft.aulast=Port&rft.aufirst=N&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activity - dependent Regulation of mRNA Stability and Nucleocytoplasmic Shuttling of Ribonucleoproteins in Hippocampal Neurons T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39824338; 4130799 JF - 35th Annual Meeting of the Society for Neuroscience AU - Cohen, J E AU - Lee, P R AU - Fields, R D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - MRNA stability KW - Hippocampus KW - Ribonucleoproteins KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39824338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Activity+-+dependent+Regulation+of+mRNA+Stability+and+Nucleocytoplasmic+Shuttling+of+Ribonucleoproteins+in+Hippocampal+Neurons&rft.au=Cohen%2C+J+E%3BLee%2C+P+R%3BFields%2C+R+D&rft.aulast=Cohen&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - D - b - Hydroxyburyrate Reduces Mitochondrial Apoptotic Signaling in Serum - Free Hypoxic Hippocampal Primary Culture T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39823641; 4128249 JF - 35th Annual Meeting of the Society for Neuroscience AU - Kashiwaya, Y AU - Masuda, R AU - Fukuhara, Y AU - Takeshima, T AU - Veech, R L Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Signal transduction KW - Cell culture KW - Hypoxia KW - Mitochondria KW - Apoptosis KW - Hippocampus KW - Serum KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39823641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=D+-+b+-+Hydroxyburyrate+Reduces+Mitochondrial+Apoptotic+Signaling+in+Serum+-+Free+Hypoxic+Hippocampal+Primary+Culture&rft.au=Kashiwaya%2C+Y%3BMasuda%2C+R%3BFukuhara%2C+Y%3BTakeshima%2C+T%3BVeech%2C+R+L&rft.aulast=Kashiwaya&rft.aufirst=Y&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Control of BDNF Transcription Through Relief of Basic Helix - Loop - Helix Protein - Mediated Repression and Activation of CREB and NF - kB in NMDA - Mediated Neuroprotection T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39822109; 4119034 JF - 35th Annual Meeting of the Society for Neuroscience AU - Lipsky, R H AU - Jiang, X AU - Tian, F AU - Wu, X. AU - Pan, H AU - Xu K. AU - Egan, S E AU - Marini, A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Cyclic AMP response element-binding protein KW - Transcription KW - N-Methyl-D-aspartic acid KW - Neuroprotection KW - Brain-derived neurotrophic factor KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39822109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Control+of+BDNF+Transcription+Through+Relief+of+Basic+Helix+-+Loop+-+Helix+Protein+-+Mediated+Repression+and+Activation+of+CREB+and+NF+-+kB+in+NMDA+-+Mediated+Neuroprotection&rft.au=Lipsky%2C+R+H%3BJiang%2C+X%3BTian%2C+F%3BWu%2C+X.%3BPan%2C+H%3BXu+K.%3BEgan%2C+S+E%3BMarini%2C+A&rft.aulast=Lipsky&rft.aufirst=R&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Dietary N - 3 Fatty Acid Deficiency and Subsequent Reduction of Brain Docosahexaenoic Acid on GABA@@dA@ Receptor Function T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39822075; 4134047 JF - 35th Annual Meeting of the Society for Neuroscience AU - Kloda, J H AU - Fedorova, I AU - Majchrzak, S AU - Swenby, N AU - Salem Jr, N AU - Mitchell, D C Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Brain KW - Fatty acids KW - ^g-Aminobutyric acid A receptors KW - Docosahexaenoic acid KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39822075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effect+of+Dietary+N+-+3+Fatty+Acid+Deficiency+and+Subsequent+Reduction+of+Brain+Docosahexaenoic+Acid+on+GABA%40%40dA%40+Receptor+Function&rft.au=Kloda%2C+J+H%3BFedorova%2C+I%3BMajchrzak%2C+S%3BSwenby%2C+N%3BSalem+Jr%2C+N%3BMitchell%2C+D+C&rft.aulast=Kloda&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Frequency - Dependent Switch of Synaptic Inhibition Polarity Recruits a Network of Hippocampal Stratum Interneurons T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39821982; 4134026 JF - 35th Annual Meeting of the Society for Neuroscience AU - Banke, T G AU - McBain, C J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Interneurons KW - Recruitment KW - Hippocampus KW - Polarity KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39821982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=A+Frequency+-+Dependent+Switch+of+Synaptic+Inhibition+Polarity+Recruits+a+Network+of+Hippocampal+Stratum+Interneurons&rft.au=Banke%2C+T+G%3BMcBain%2C+C+J&rft.aulast=Banke&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An fMRI Study of Simultaneous Practice - Related Changes in Perception and Response Selection T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39821936; 4119545 JF - 35th Annual Meeting of the Society for Neuroscience AU - Jansma, J M AU - van Raalten, T.R. AU - Ramsey, N F AU - van Gelderen, P AU - Duyn, J H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Perception KW - Functional magnetic resonance imaging KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39821936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=An+fMRI+Study+of+Simultaneous+Practice+-+Related+Changes+in+Perception+and+Response+Selection&rft.au=Jansma%2C+J+M%3Bvan+Raalten%2C+T.R.%3BRamsey%2C+N+F%3Bvan+Gelderen%2C+P%3BDuyn%2C+J+H&rft.aulast=Jansma&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Different Neurons in the Inferior Temporal Cortex Reflect where Monkeys will and should Look T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39821726; 4119955 JF - 35th Annual Meeting of the Society for Neuroscience AU - Messinger, A AU - Squire, L R AU - Zola, S M AU - Albright, T D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Cortex (temporal) KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39821726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Different+Neurons+in+the+Inferior+Temporal+Cortex+Reflect+where+Monkeys+will+and+should+Look&rft.au=Messinger%2C+A%3BSquire%2C+L+R%3BZola%2C+S+M%3BAlbright%2C+T+D&rft.aulast=Messinger&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NMDA Receptors Interact with GIPC T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39821703; 4127141 JF - 35th Annual Meeting of the Society for Neuroscience AU - Yi, Z. AU - Petralia, R S AU - Sans, N AU - Wenthold, R J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Glutamic acid receptors KW - N-Methyl-D-aspartic acid receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39821703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=NMDA+Receptors+Interact+with+GIPC&rft.au=Yi%2C+Z.%3BPetralia%2C+R+S%3BSans%2C+N%3BWenthold%2C+R+J&rft.aulast=Yi&rft.aufirst=Z.&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecules Interacting with Disrupted - in - Schizophrenia - 1(DISC1) are Differentially Expressed in Schizophrenia and Regulated by SNPs Associated with the Disease T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39821363; 4119878 JF - 35th Annual Meeting of the Society for Neuroscience AU - Lipska, B K AU - Peters, T AU - Halim, N AU - Mitkus, S AU - Sawa, A AU - Hyde, T M AU - Weinberger, D R AU - Kleinman, J E Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Schizophrenia KW - Mental disorders KW - Single-nucleotide polymorphism KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39821363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Molecules+Interacting+with+Disrupted+-+in+-+Schizophrenia+-+1%28DISC1%29+are+Differentially+Expressed+in+Schizophrenia+and+Regulated+by+SNPs+Associated+with+the+Disease&rft.au=Lipska%2C+B+K%3BPeters%2C+T%3BHalim%2C+N%3BMitkus%2C+S%3BSawa%2C+A%3BHyde%2C+T+M%3BWeinberger%2C+D+R%3BKleinman%2C+J+E&rft.aulast=Lipska&rft.aufirst=B&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cdk5 Activity is Required to Regulate Pain Signaling T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39821321; 4119383 JF - 35th Annual Meeting of the Society for Neuroscience AU - Pareek, T K AU - Keller, J AU - Kesavapany, S AU - Pant, H C AU - Iadarola, M J AU - Kulkarni, A B Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Pain KW - Signal transduction KW - Cyclin-dependent kinase 5 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39821321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Cdk5+Activity+is+Required+to+Regulate+Pain+Signaling&rft.au=Pareek%2C+T+K%3BKeller%2C+J%3BKesavapany%2C+S%3BPant%2C+H+C%3BIadarola%2C+M+J%3BKulkarni%2C+A+B&rft.aulast=Pareek&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mapping a Cortical - Subcortical Loop in Vivo Using Manganese - Enhanced Magnetic Resonance Imaging in Monkey T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39820512; 4126865 JF - 35th Annual Meeting of the Society for Neuroscience AU - Simmons, J M AU - Lizak, M J AU - Ortiz, M AU - Koretsky, A P AU - Richmond, B J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Mapping KW - Manganese KW - Magnetic resonance imaging KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39820512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Mapping+a+Cortical+-+Subcortical+Loop+in+Vivo+Using+Manganese+-+Enhanced+Magnetic+Resonance+Imaging+in+Monkey&rft.au=Simmons%2C+J+M%3BLizak%2C+M+J%3BOrtiz%2C+M%3BKoretsky%2C+A+P%3BRichmond%2C+B+J&rft.aulast=Simmons&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chronic Valproate Does Not Alter the Kinetics of Docosahexaenoic Acid within Brain Phospholipids of the Unanesthetized Rat T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39820005; 4121359 JF - 35th Annual Meeting of the Society for Neuroscience AU - Lee, H AU - Rao, J S AU - chang, L AU - Rapoport, S I AU - Bazinet, R P Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Kinetics KW - Brain KW - Docosahexaenoic acid KW - Phospholipids KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39820005?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Chronic+Valproate+Does+Not+Alter+the+Kinetics+of+Docosahexaenoic+Acid+within+Brain+Phospholipids+of+the+Unanesthetized+Rat&rft.au=Lee%2C+H%3BRao%2C+J+S%3Bchang%2C+L%3BRapoport%2C+S+I%3BBazinet%2C+R+P&rft.aulast=Lee&rft.aufirst=H&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Fast, Windows - Based Dynamic Clamp T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39819681; 4128628 DE: JF - 35th Annual Meeting of the Society for Neuroscience AU - Mogri, M AU - Milescu, L AU - Ptak, K AU - Smith, J C Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39819681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=A+Fast%2C+Windows+-+Based+Dynamic+Clamp&rft.au=Mogri%2C+M%3BMilescu%2C+L%3BPtak%2C+K%3BSmith%2C+J+C&rft.aulast=Mogri&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Family of Adhesion - Like Molecules Associated with the NMDA Receptor Complex T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39819219; 4127142 JF - 35th Annual Meeting of the Society for Neuroscience AU - Seabold, G K AU - Wang, C Y AU - Petralia, R S AU - Wenthold, R J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Glutamic acid receptors KW - N-Methyl-D-aspartic acid receptors KW - Adhesion KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39819219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=A+Family+of+Adhesion+-+Like+Molecules+Associated+with+the+NMDA+Receptor+Complex&rft.au=Seabold%2C+G+K%3BWang%2C+C+Y%3BPetralia%2C+R+S%3BWenthold%2C+R+J&rft.aulast=Seabold&rft.aufirst=G&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activity - dependent Transcription of BDNF Through Promoter 3 Contributes Selectively to Long - term Hippocampal Plasticity and Long - term Memory T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39818634; 4128965 JF - 35th Annual Meeting of the Society for Neuroscience AU - Sakata, K AU - Woo, N AU - Wu, J. AU - Shen, L AU - Lu, B. Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Promoters KW - Transcription KW - Plasticity (hippocampal) KW - Brain-derived neurotrophic factor KW - Hippocampus KW - Memory KW - Plasticity KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39818634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Activity+-+dependent+Transcription+of+BDNF+Through+Promoter+3+Contributes+Selectively+to+Long+-+term+Hippocampal+Plasticity+and+Long+-+term+Memory&rft.au=Sakata%2C+K%3BWoo%2C+N%3BWu%2C+J.%3BShen%2C+L%3BLu%2C+B.&rft.aulast=Sakata&rft.aufirst=K&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Regulation of mGluR7 Trafficking T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39818529; 4120252 DE: JF - 35th Annual Meeting of the Society for Neuroscience AU - Lavezzari, G AU - Roche, K W Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39818529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Differential+Regulation+of+mGluR7+Trafficking&rft.au=Lavezzari%2C+G%3BRoche%2C+K+W&rft.aulast=Lavezzari&rft.aufirst=G&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - m - Calpain Activates Microglia and is Toxic to Dopaminergic Neurons: Mechanisms of Reactive Microgliosis T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39818336; 4129893 JF - 35th Annual Meeting of the Society for Neuroscience AU - Block, M L AU - Wilson, B AU - Pang, H AU - Qian, L AU - Wu, X. AU - Gao, X AU - Zhang, W AU - Mandavilli, B AU - Dallas, S AU - Miller, D AU - Hong, J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Microglia KW - Calpain KW - Neurons KW - Dopamine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39818336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=m+-+Calpain+Activates+Microglia+and+is+Toxic+to+Dopaminergic+Neurons%3A+Mechanisms+of+Reactive+Microgliosis&rft.au=Block%2C+M+L%3BWilson%2C+B%3BPang%2C+H%3BQian%2C+L%3BWu%2C+X.%3BGao%2C+X%3BZhang%2C+W%3BMandavilli%2C+B%3BDallas%2C+S%3BMiller%2C+D%3BHong%2C+J&rft.aulast=Block&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Awareness Modulates MEG Responses to Fearful Faces T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39818130; 4129826 DE: JF - 35th Annual Meeting of the Society for Neuroscience AU - Crocker, L D AU - Japee, S AU - Holroyd, T AU - Carver, F W AU - Pessoa, L AU - Ungerleider, L G Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39818130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Awareness+Modulates+MEG+Responses+to+Fearful+Faces&rft.au=Crocker%2C+L+D%3BJapee%2C+S%3BHolroyd%2C+T%3BCarver%2C+F+W%3BPessoa%2C+L%3BUngerleider%2C+L+G&rft.aulast=Crocker&rft.aufirst=L&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dendritic Release of Dopamine Modulates GABA Neurotransmission in Substantia Nigra Pars Reticulata: Iontophoresis in Awake Unrestrained Rats T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39815923; 4129331 JF - 35th Annual Meeting of the Society for Neuroscience AU - Windels, F AU - Kiyatkin, E A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Rats KW - Neurotransmission KW - Substantia nigra pars reticulata KW - Iontophoresis KW - ^g-Aminobutyric acid KW - Dopamine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39815923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Dendritic+Release+of+Dopamine+Modulates+GABA+Neurotransmission+in+Substantia+Nigra+Pars+Reticulata%3A+Iontophoresis+in+Awake+Unrestrained+Rats&rft.au=Windels%2C+F%3BKiyatkin%2C+E+A&rft.aulast=Windels&rft.aufirst=F&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Variations between Normotensive and Hypertensive Rats in Brain Microvessels and Potential Targets of AT1 Receptor Antagonists T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39813760; 4119751 JF - 35th Annual Meeting of the Society for Neuroscience AU - Zhou, J AU - Macova, M AU - Ando, H AU - Saavedra, J M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Brain KW - Rats KW - Antagonists KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39813760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Genetic+Variations+between+Normotensive+and+Hypertensive+Rats+in+Brain+Microvessels+and+Potential+Targets+of+AT1+Receptor+Antagonists&rft.au=Zhou%2C+J%3BMacova%2C+M%3BAndo%2C+H%3BSaavedra%2C+J+M&rft.aulast=Zhou&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chondroitin Sulfate Proteoglycan Glycosaminoglycan Chain Synthesis: a Potential Molecular Target T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39811604; 4125636 JF - 35th Annual Meeting of the Society for Neuroscience AU - Laabs, T L AU - Fawcett, J W AU - Geller, H M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Sulfate KW - Glycosaminoglycans KW - Chondroitin sulfate KW - Proteoglycans KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39811604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Chondroitin+Sulfate+Proteoglycan+Glycosaminoglycan+Chain+Synthesis%3A+a+Potential+Molecular+Target&rft.au=Laabs%2C+T+L%3BFawcett%2C+J+W%3BGeller%2C+H+M&rft.aulast=Laabs&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Protein Synthesis Inhibitors Prevent Presynaptically Expressed Long - Term Depression in the Sensorimotor Striatum T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39811358; 4125577 JF - 35th Annual Meeting of the Society for Neuroscience AU - Ronesi, J AU - Yin, H H AU - Lovinger, D M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Depression KW - Protein biosynthesis KW - Neostriatum KW - Protein synthesis KW - Inhibitors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39811358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Protein+Synthesis+Inhibitors+Prevent+Presynaptically+Expressed+Long+-+Term+Depression+in+the+Sensorimotor+Striatum&rft.au=Ronesi%2C+J%3BYin%2C+H+H%3BLovinger%2C+D+M&rft.aulast=Ronesi&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Studies of Oxytocin Transcription in the Rat Hypothalamus Using an Intron - Specific Probe T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39804145; 4134727 JF - 35th Annual Meeting of the Society for Neuroscience AU - Yue, C AU - Mutsuga, N AU - Scordalakes, E M AU - Gainer, H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Probes KW - Introns KW - Transcription KW - Oxytocin KW - Hypothalamus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39804145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Studies+of+Oxytocin+Transcription+in+the+Rat+Hypothalamus+Using+an+Intron+-+Specific+Probe&rft.au=Yue%2C+C%3BMutsuga%2C+N%3BScordalakes%2C+E+M%3BGainer%2C+H&rft.aulast=Yue&rft.aufirst=C&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Angiotensin II Receptor Antagonist Reduces Proinflammatory Cytokine Production in Rat Tissues T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39801026; 4134758 JF - 35th Annual Meeting of the Society for Neuroscience AU - Fernando, L P AU - Pavel, J AU - Nazarali, A J AU - Saavedra, J M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Cytokines KW - Angiotensin II receptors KW - Inflammation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39801026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Angiotensin+II+Receptor+Antagonist+Reduces+Proinflammatory+Cytokine+Production+in+Rat+Tissues&rft.au=Fernando%2C+L+P%3BPavel%2C+J%3BNazarali%2C+A+J%3BSaavedra%2C+J+M&rft.aulast=Fernando&rft.aufirst=L&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Distribution of KCNQ Channel Subunits in Hippocampal CA1 Interneurons T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39800201; 4132440 JF - 35th Annual Meeting of the Society for Neuroscience AU - Churchill, J F AU - Travis, K A AU - Statland, J M AU - Saraga, F AU - Skinner, F K AU - McBain, C J AU - Lawrence, J J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Channels KW - Interneurons KW - Potassium channels (voltage-gated) KW - Hippocampus KW - Differential distribution KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39800201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Differential+Distribution+of+KCNQ+Channel+Subunits+in+Hippocampal+CA1+Interneurons&rft.au=Churchill%2C+J+F%3BTravis%2C+K+A%3BStatland%2C+J+M%3BSaraga%2C+F%3BSkinner%2C+F+K%3BMcBain%2C+C+J%3BLawrence%2C+J+J&rft.aulast=Churchill&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Quantal Size Variation is Mainly Determined by Transmitter Concentration in Glutamatergic Vesicles T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39791451; 4134137 JF - 35th Annual Meeting of the Society for Neuroscience AU - Wu, X. AU - Wu, L. Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Vesicles KW - Glutamatergic transmission KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39791451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Quantal+Size+Variation+is+Mainly+Determined+by+Transmitter+Concentration+in+Glutamatergic+Vesicles&rft.au=Wu%2C+X.%3BWu%2C+L.&rft.aulast=Wu&rft.aufirst=X.&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Amygdala Activation in Affective Priming: An MEG Study T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39785473; 4122895 JF - 35th Annual Meeting of the Society for Neuroscience AU - Munoz, K E AU - Garolera, M AU - Goldberg, T E AU - Elvevag, B AU - Carver, F W AU - Zoltick, B J AU - Weinberger, D R AU - Coppola, R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Amygdala KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39785473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Amygdala+Activation+in+Affective+Priming%3A+An+MEG+Study&rft.au=Munoz%2C+K+E%3BGarolera%2C+M%3BGoldberg%2C+T+E%3BElvevag%2C+B%3BCarver%2C+F+W%3BZoltick%2C+B+J%3BWeinberger%2C+D+R%3BCoppola%2C+R&rft.aulast=Munoz&rft.aufirst=K&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Isoflurane Reduces Excitability and Glutamate Release at the Drosophila Neuromuscular Junction: The Role of Leak K@@u+@ Channels T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39778409; 4122184 JF - 35th Annual Meeting of the Society for Neuroscience AU - Sandstrom, D J AU - Nash, H A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Potassium channels KW - Glutamic acid KW - Isoflurane KW - Neuromuscular junctions KW - Excitability KW - Drosophila KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39778409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Isoflurane+Reduces+Excitability+and+Glutamate+Release+at+the+Drosophila+Neuromuscular+Junction%3A+The+Role+of+Leak+K%40%40u%2B%40+Channels&rft.au=Sandstrom%2C+D+J%3BNash%2C+H+A&rft.aulast=Sandstrom&rft.aufirst=D&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Delivery of a Sensory Neuron Specific Promoter Region for the Mouse Scn10a Gene Using an Adenoviral Dual Reporter Construct T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39777456; 4122143 JF - 35th Annual Meeting of the Society for Neuroscience AU - Puhl, H L AU - Chen, H AU - Ikeda, S R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Promoters KW - Sensory neurons KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39777456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Delivery+of+a+Sensory+Neuron+Specific+Promoter+Region+for+the+Mouse+Scn10a+Gene+Using+an+Adenoviral+Dual+Reporter+Construct&rft.au=Puhl%2C+H+L%3BChen%2C+H%3BIkeda%2C+S+R&rft.aulast=Puhl&rft.aufirst=H&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distribution of a - CaMKII near the Presynaptic Active Zone in Resting and Stimulated Synapses T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39773901; 4118969 JF - 35th Annual Meeting of the Society for Neuroscience AU - Reese, T S AU - Dosemeci, A AU - Winters, C A AU - Tao-Cheng, J H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Synapses KW - Ca@@u2+@/calmodulin-dependent protein kinase II KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39773901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Distribution+of+a+-+CaMKII+near+the+Presynaptic+Active+Zone+in+Resting+and+Stimulated+Synapses&rft.au=Reese%2C+T+S%3BDosemeci%2C+A%3BWinters%2C+C+A%3BTao-Cheng%2C+J+H&rft.aulast=Reese&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sulfation of Astrocyte Chondroitin Sulfate Proteoglycan in Neuronal Growth T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39769540; 4125637 JF - 35th Annual Meeting of the Society for Neuroscience AU - Wang, H AU - Katagiri, Y AU - Tan, F AU - Geller, H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Sulfate KW - Chondroitin sulfate KW - Proteoglycans KW - Astrocytes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39769540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Sulfation+of+Astrocyte+Chondroitin+Sulfate+Proteoglycan+in+Neuronal+Growth&rft.au=Wang%2C+H%3BKatagiri%2C+Y%3BTan%2C+F%3BGeller%2C+H&rft.aulast=Wang&rft.aufirst=H&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mass of the Postsynaptic Density and the Number of Copies of Three Key Molecules T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39767694; 4119711 JF - 35th Annual Meeting of the Society for Neuroscience AU - Chen, X AU - Vinade, L AU - Leapman, R D AU - Petersen, J D AU - Nakagawa, T AU - Phillips, T M AU - Sheng, M AU - Reese, T S Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Postsynaptic density KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39767694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Mass+of+the+Postsynaptic+Density+and+the+Number+of+Copies+of+Three+Key+Molecules&rft.au=Chen%2C+X%3BVinade%2C+L%3BLeapman%2C+R+D%3BPetersen%2C+J+D%3BNakagawa%2C+T%3BPhillips%2C+T+M%3BSheng%2C+M%3BReese%2C+T+S&rft.aulast=Chen&rft.aufirst=X&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1. AN - 68765610; 16157596 AB - The cellular response to hypoxia is, at least in part, mediated by the transcriptional regulation of hypoxia-responsive genes involved in balancing the intracellular ATP production and consumption. Recent evidence suggests that the transcription factor, HIF-1alpha, functions as a master regulator of oxygen homeostasis by controlling a broad range of cellular events in hypoxia. In normoxia, HIF-1alpha is targeted for destruction via prolyl hydroxylation, an oxygen-dependent modification that signals for recognition by the ubiquitin ligase complex containing the von Hippel-Lindau tumor suppressor. Three HIF prolyl hydroxylases (EGLN1, EGLN2, and EGLN3) have been identified in mammals, among which EGLN1 and EGLN3 are hypoxia-inducible at their mRNA levels in an HIF-1alpha-dependent manner. In this study, we demonstrated that apart from promoting HIF-1alpha proteolysis in normoxia, EGLN1 specifically represses HIF-1alpha transcriptional activity in hypoxia. Ectopic expression of EGLN1 inhibited HIF-1alpha transcriptional activity without altering its protein levels in a von Hippel-Lindau-deficient cell line, indicating a discrete activity of EGLN1 in transcriptional repression. Conversely, silencing of EGLN1 expression augmented HIF-1alpha transcriptional activity and its target gene expression in hypoxia. Thus, we proposed that the accumulated EGLN1 in hypoxia acts as a negative-feedback mechanism to modulate HIF-1alpha target gene expression. Our finding also provided new insight into the pharmacological manipulation of the HIF prolyl hydroxylase for ischemic diseases. JF - The Journal of biological chemistry AU - To, Kenneth K W AU - Huang, L Eric AD - Laboratory of Human Carcinogenesis, NCI, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2005/11/11/ PY - 2005 DA - 2005 Nov 11 SP - 38102 EP - 38107 VL - 280 IS - 45 SN - 0021-9258, 0021-9258 KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - 0 KW - Immediate-Early Proteins KW - EGLN1 protein, human KW - EC 1.14.11.2 KW - Procollagen-Proline Dioxygenase KW - Hypoxia-Inducible Factor-Proline Dioxygenases KW - EC 1.14.11.29 KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Animals KW - Genes, Reporter -- genetics KW - Protein Binding -- drug effects KW - Oxygen -- pharmacology KW - Oxygen -- metabolism KW - Humans KW - Cell Line KW - Immediate-Early Proteins -- genetics KW - Hypoxia-Inducible Factor 1, alpha Subunit -- genetics KW - Procollagen-Proline Dioxygenase -- genetics KW - Immediate-Early Proteins -- metabolism KW - Hypoxia-Inducible Factor 1, alpha Subunit -- antagonists & inhibitors KW - Gene Silencing KW - Transcription, Genetic KW - Procollagen-Proline Dioxygenase -- metabolism KW - Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68765610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Suppression+of+hypoxia-inducible+factor+1alpha+%28HIF-1alpha%29+transcriptional+activity+by+the+HIF+prolyl+hydroxylase+EGLN1.&rft.au=To%2C+Kenneth+K+W%3BHuang%2C+L+Eric&rft.aulast=To&rft.aufirst=Kenneth+K&rft.date=2005-11-11&rft.volume=280&rft.issue=45&rft.spage=38102&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-12 N1 - Date created - 2005-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Methods. 2002 Feb;26(2):199-213 [12054897] Science. 2002 Feb 1;295(5556):858-61 [11823643] J Biol Chem. 2002 Jul 19;277(29):26351-5 [12042299] FASEB J. 2002 Aug;16(10):1151-62 [12153983] J Biol Chem. 2002 Aug 16;277(33):29936-44 [12052835] J Biol Chem. 2002 Nov 1;277(44):41750-5 [12205091] J Biol Chem. 2003 Jan 17;278(3):1802-6 [12446723] J Cell Sci. 2003 Apr 1;116(Pt 7):1319-26 [12615973] J Biol Chem. 2003 May 30;278(22):19575-8 [12639949] Nat Med. 2003 Jun;9(6):677-84 [12778166] EMBO J. 2003 Aug 15;22(16):4082-90 [12912907] Nat Rev Cancer. 2003 Oct;3(10):721-32 [13130303] Nat Rev Drug Discov. 2003 Oct;2(10):803-11 [14526383] J Biol Chem. 2003 Dec 5;278(49):48690-5 [14506252] Curr Opin Genet Dev. 2004 Feb;14(1):81-5 [15108809] EMBO J. 2004 May 5;23(9):1949-56 [15071503] FASEB J. 2004 Jun;18(9):1028-30 [15084514] Drug Discov Today. 2004 Aug 15;9(16):704-11 [15341784] J Biol Chem. 2004 Sep 10;279(37):38458-65 [15247232] J Biol Chem. 1993 Oct 15;268(29):21513-8 [8408001] J Biol Chem. 1995 Jan 20;270(3):1230-7 [7836384] Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5510-4 [7539918] J Biol Chem. 1996 Jul 26;271(30):17771-8 [8663540] Physiol Rev. 1996 Jul;76(3):839-85 [8757790] Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12969-73 [8917528] J Biol Chem. 1996 Dec 13;271(50):32253-9 [8943284] J Biol Chem. 1997 Apr 25;272(17):11205-14 [9111021] J Biol Chem. 1997 Sep 5;272(36):22642-7 [9278421] Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):7987-92 [9653127] EMBO J. 1998 Nov 16;17(22):6573-86 [9822602] Genes Dev. 1999 Jan 1;13(1):64-75 [9887100] Nature. 1999 May 20;399(6733):271-5 [10353251] Cell Cycle. 2004 Jul;3(7):853-4 [15190211] Mol Cell. 2005 Feb 18;17(4):503-12 [15721254] Mol Cell. 2005 Mar 18;17(6):793-803 [15780936] Proc Natl Acad Sci U S A. 2005 May 24;102(21):7481-6 [15897452] Annu Rev Cell Dev Biol. 1999;15:551-78 [10611972] Nat Cell Biol. 2000 Jul;2(7):423-7 [10878807] J Biol Chem. 2000 Aug 18;275(33):25733-41 [10823831] EMBO J. 2000 Aug 15;19(16):4298-309 [10944113] Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10430-5 [10973499] FEBS Lett. 2001 Feb 23;491(1-2):85-90 [11226425] Science. 2001 Apr 20;292(5516):464-8 [11292862] Science. 2001 Apr 20;292(5516):468-72 [11292861] J Biol Chem. 2001 Feb 2;276(5):3550-4 [11063749] Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9630-5 [11504942] Gene. 2001 Sep 5;275(1):125-32 [11574160] Cell. 2001 Oct 5;107(1):43-54 [11595184] Genes Dev. 2001 Oct 15;15(20):2675-86 [11641274] Science. 2001 Nov 9;294(5545):1337-40 [11598268] Genes Dev. 2002 Jun 15;16(12):1466-71 [12080085] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of protease-resistant prion protein inhibitors in cell cultures infected with two strains of mouse and sheep scrapie AN - 20237623; 6535846 AB - The transmissible spongiform encephalopathies (TSEs) are fatal neurodegenerative diseases. A primary therapeutic target for TSE intervention has been a protease-resistant form of prion protein known as PrP super(Sc) or PrP-res. In vitro testing of mouse scrapie-infected cell cultures has identified many PrP-res inhibitors that also have activity in vivo. Here we identify 32 new inhibitors of two strains of mouse scrapie PrP-res. Furthermore, to investigate the species-specificity of these and other PrP-res inhibitors, we have developed a high-throughput cell culture assay based on Rov9 cells chronically-infected with sheep scrapie. Of 32 inhibitors of murine PrP-res that were also tested in the Rov9 cells, only six showed inhibitory activity against sheep PrP-res. The three most potent inhibitors of both murine and ovine PrP-res formation (with 50% inhibition at less than or equal to 5 mu M) were tannic acid, pentosan polysulfate and Fe(III) deuteroporphyrin 2,4-bisethyleneglycol. The latter two have anti-mouse scrapie activity in vivo. These results identify new inhibitors of murine and ovine PrP-res formation and reinforce the idea that compounds effective against PrP-res from one species or strain cannot be assumed to be active against others. JF - Neuroscience Letters AU - Kocisko, DA AU - Engel, AL AU - Harbuck, K AU - Arnold, K M AU - Olsen, E A AU - Raymond, L D AU - Vilette, D AU - Caughey, B AD - Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S. 4th Street, Hamilton, MT 59840, USA Y1 - 2005/11/11/ PY - 2005 DA - 2005 Nov 11 SP - 106 EP - 111 VL - 388 IS - 2 SN - 0304-3940, 0304-3940 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Transmissible spongiform encephalopathy KW - Neurodegenerative diseases KW - Nervous system KW - Prion protein KW - Cell culture KW - Scrapie KW - Tannic acid KW - pentosan polysulfate KW - N3 11028:Neuropharmacology & toxicology KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20237623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+Letters&rft.atitle=Comparison+of+protease-resistant+prion+protein+inhibitors+in+cell+cultures+infected+with+two+strains+of+mouse+and+sheep+scrapie&rft.au=Kocisko%2C+DA%3BEngel%2C+AL%3BHarbuck%2C+K%3BArnold%2C+K+M%3BOlsen%2C+E+A%3BRaymond%2C+L+D%3BVilette%2C+D%3BCaughey%2C+B&rft.aulast=Kocisko&rft.aufirst=DA&rft.date=2005-11-11&rft.volume=388&rft.issue=2&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Neuroscience+Letters&rft.issn=03043940&rft_id=info:doi/10.1016%2Fj.neulet.2005.06.053 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Transmissible spongiform encephalopathy; Neurodegenerative diseases; Nervous system; Prion protein; Cell culture; Tannic acid; Scrapie; pentosan polysulfate DO - http://dx.doi.org/10.1016/j.neulet.2005.06.053 ER - TY - JOUR T1 - Selection of control genes for quantitative RT-PCR based on microarray data AN - 17404665; 6524202 AB - Use of internal reference gene(s) is necessary for adequate quantification of target gene expression by RT-PCR. Herein, we elaborated a strategy of control gene selection based on microarray data and illustrated it by analyzing endomyocardial biopsies with acute cardiac rejection and infection. Using order statistics and binomial distribution we evaluated the probability of finding low-varying genes by chance. For analysis, the microarray data were divided into two sample subsets. Among the first 10% of genes with the lowest standard deviations, we found 14 genes common to both subsets. After normalization using two selected genes, high correlation was observed between expression of target genes evaluated by microarray and RT-PCR, and in independent dataset by RT-PCR (r=0.9, p<0.001). In conclusion, we showed a simple and reliable strategy of selection and validation of control genes for RT-PCR from microarray data that can be easily applied for different experimental designs and tissues. JF - Biochemical and Biophysical Research Communications AU - Shulzhenko, N AU - Yambartsev, A AU - Goncalves-Primo, A AU - Gerbase-DeLima, M AU - Morgun, A AD - Pediatrics Department, Universidade Federal de Sao Paulo-UNIFESP, Sao Paulo, SP, Brazil, morguna@niaid.nih.gov Y1 - 2005/11/11/ PY - 2005 DA - 2005 Nov 11 SP - 306 EP - 312 PB - Elsevier Inc. VL - 337 IS - 1 SN - 0006-291X, 0006-291X KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Heart KW - Data processing KW - Statistics KW - Standard deviation KW - Statistical analysis KW - Polymerase chain reaction KW - Biopsy KW - Infection KW - N 14025:RNA/DNA role in infection & immune response KW - W 30960:Bioinformatics & Computer Applications KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17404665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Selection+of+control+genes+for+quantitative+RT-PCR+based+on+microarray+data&rft.au=Shulzhenko%2C+N%3BYambartsev%2C+A%3BGoncalves-Primo%2C+A%3BGerbase-DeLima%2C+M%3BMorgun%2C+A&rft.aulast=Shulzhenko&rft.aufirst=N&rft.date=2005-11-11&rft.volume=337&rft.issue=1&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1016%2Fj.bbrc.2005.09.048 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Heart; Standard deviation; Statistics; Data processing; Statistical analysis; Polymerase chain reaction; Biopsy; Infection DO - http://dx.doi.org/10.1016/j.bbrc.2005.09.048 ER - TY - JOUR T1 - Visualization of the Phosphorylated Active Site Loop of the Cytoplasmic B Domain of the Mannitol Transporter II super(M) super(a) super(n) super(n) super(i) super(t) super(o) super(l) of the Escherichia coli Phosphotransferase System by NMR Spectroscopy and Residual Dipolar Couplings AN - 17403643; 6523617 AB - The solution structure of a stably phosphorylated form of the cytoplasmic B domain of the mannitol-specific transporter (IIB super(M) super(t) super(l)) of the Escherichia coli phosphotransferase system, containing a mutation of the active site Cys384 to Ser, has been solved by NMR. The strategy employed relies principally on backbone residual dipolar couplings recorded in three different alignment media, supplemented by nuclear Overhauser enhancement data and torsion angle restraints related specifically to the active site loop (residues 383-393). As judged from the dipolar coupling data, the remainder of the structure is unchanged upon phosphorylation within the errors of the coordinates of the previously determined solution structure of unphosphorylated wild-type IIB super(M) super(t) super(l). Thus, only the active site loop was refined. Phosphorylation results in a backbone atomic rms shift of } .7A in the active site loop. The resulting conformation is less than 0.5A away from the equivalent P-loop in both the low and high molecular mass eukaryotic tyrosine phosphatases. super(3)J sub(N) sub(P) coupling constant measurements using quantitative J-correlation spectroscopy provide a direct demonstration of a hydrogen bond between the phosphoryl group and the backbone amide of Ser391 at position i+7 from phospho-Ser384, with an approximately linear P-O-H sub(N) bond angle. The structure also reveals additional hydrogen bonding interactions involving the backbone amides of residues at positions i+4 and i+5, and the hydroxyl groups of two serine residues at positions i+6 and i+7 that stabilize the phosphoryl group. respectively, of II super(M) super(t) super(l) JF - Journal of Molecular Biology AU - Suh, J Y AU - Tang, C AU - Cai, M AU - Clore, G AD - Building 5, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA, mariusc@intra.niddk.nih.gov Y1 - 2005/11/11/ PY - 2005 DA - 2005 Nov 11 SP - 1129 EP - 1136 VL - 353 IS - 5 SN - 0022-2836, 0022-2836 KW - Microbiology Abstracts B: Bacteriology KW - Wild type KW - phosphotransferase KW - Spectroscopy KW - Protein-tyrosine-phosphatase KW - Phosphorylation KW - Mannitol KW - Hydrogen bonding KW - Magnetic resonance spectroscopy KW - Escherichia coli KW - N.M.R. KW - Active sites KW - Mutation KW - amides KW - Conformation KW - J 02728:Enzymes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17403643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Visualization+of+the+Phosphorylated+Active+Site+Loop+of+the+Cytoplasmic+B+Domain+of+the+Mannitol+Transporter+II+super%28M%29+super%28a%29+super%28n%29+super%28n%29+super%28i%29+super%28t%29+super%28o%29+super%28l%29+of+the+Escherichia+coli+Phosphotransferase+System+by+NMR+Spectroscopy+and+Residual+Dipolar+Couplings&rft.au=Suh%2C+J+Y%3BTang%2C+C%3BCai%2C+M%3BClore%2C+G&rft.aulast=Suh&rft.aufirst=J&rft.date=2005-11-11&rft.volume=353&rft.issue=5&rft.spage=1129&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2005.09.033 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Wild type; phosphotransferase; Spectroscopy; Protein-tyrosine-phosphatase; Phosphorylation; Hydrogen bonding; Mannitol; Magnetic resonance spectroscopy; N.M.R.; Active sites; amides; Mutation; Conformation; Escherichia coli DO - http://dx.doi.org/10.1016/j.jmb.2005.09.033 ER - TY - CPAPER T1 - Inflammatory Protein Profile During Systemic High Dose Interleukin-2 Administration T2 - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AN - 39814967; 4074306 JF - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AU - Rossi, Leonardo Y1 - 2005/11/10/ PY - 2005 DA - 2005 Nov 10 KW - Interleukin 2 KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39814967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.atitle=Inflammatory+Protein+Profile+During+Systemic+High+Dose+Interleukin-2+Administration&rft.au=Rossi%2C+Leonardo&rft.aulast=Rossi&rft.aufirst=Leonardo&rft.date=2005-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/meetings/am05/presentations.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Factors that Influence Responses to Adoptive Cancer Immunotherapy T2 - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AN - 39809602; 4074291 JF - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AU - Robbins, Paul F Y1 - 2005/11/10/ PY - 2005 DA - 2005 Nov 10 KW - Cancer KW - Immunotherapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39809602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.atitle=Factors+that+Influence+Responses+to+Adoptive+Cancer+Immunotherapy&rft.au=Robbins%2C+Paul+F&rft.aulast=Robbins&rft.aufirst=Paul&rft.date=2005-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/meetings/am05/presentations.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hematopoietic Stem Cell Transplant with Lymphodepletion Augments T Cell-Based Adoptive Immunotherapy T2 - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AN - 39796400; 4074317 JF - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AU - Wrzesinski, Claudia Y1 - 2005/11/10/ PY - 2005 DA - 2005 Nov 10 KW - Adoptive immunotherapy KW - Transplants KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39796400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.atitle=Hematopoietic+Stem+Cell+Transplant+with+Lymphodepletion+Augments+T+Cell-Based+Adoptive+Immunotherapy&rft.au=Wrzesinski%2C+Claudia&rft.aulast=Wrzesinski&rft.aufirst=Claudia&rft.date=2005-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/meetings/am05/presentations.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Profiling of BCC Treated with the Immunomodifier Imiquimod (ALDARA @@uTM@) Reveals Key Signatures of Tumor Rejection T2 - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AN - 39796273; 4074304 JF - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AU - Panelli, Monica Y1 - 2005/11/10/ PY - 2005 DA - 2005 Nov 10 KW - Imiquimod KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39796273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.atitle=Gene+Profiling+of+BCC+Treated+with+the+Immunomodifier+Imiquimod+%28ALDARA+%40%40uTM%40%29+Reveals+Key+Signatures+of+Tumor+Rejection&rft.au=Panelli%2C+Monica&rft.aulast=Panelli&rft.aufirst=Monica&rft.date=2005-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/meetings/am05/presentations.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytokines and Tumor Immunology T2 - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AN - 39789372; 4074327 JF - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AU - Wigginton, Jon M Y1 - 2005/11/10/ PY - 2005 DA - 2005 Nov 10 KW - Immunology KW - Cytokines KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39789372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.atitle=Cytokines+and+Tumor+Immunology&rft.au=Wigginton%2C+Jon+M&rft.aulast=Wigginton&rft.aufirst=Jon&rft.date=2005-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/meetings/am05/presentations.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IL-2 Paradoxically Controls Tolerance and Immunity to a Tumor/Self-Antigen T2 - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AN - 39774790; 4074278 JF - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AU - Antony, Paul A Y1 - 2005/11/10/ PY - 2005 DA - 2005 Nov 10 KW - Interleukin 2 KW - Immunity KW - Autoantigens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39774790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.atitle=IL-2+Paradoxically+Controls+Tolerance+and+Immunity+to+a+Tumor%2FSelf-Antigen&rft.au=Antony%2C+Paul+A&rft.aulast=Antony&rft.aufirst=Paul&rft.date=2005-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/meetings/am05/presentations.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Treatment of Patients with Metastatic Melanoma by Infusion of Anti-MART-1 TCR-Gene Engineered Lymphocytes T2 - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AN - 39763201; 4074315 JF - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AU - Morgan, Richard Y1 - 2005/11/10/ PY - 2005 DA - 2005 Nov 10 KW - Lymphocytes KW - T-cell receptor KW - Melanoma KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39763201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.atitle=Treatment+of+Patients+with+Metastatic+Melanoma+by+Infusion+of+Anti-MART-1+TCR-Gene+Engineered+Lymphocytes&rft.au=Morgan%2C+Richard&rft.aulast=Morgan&rft.aufirst=Richard&rft.date=2005-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/meetings/am05/presentations.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proteasome Inhibition Upregulates the Cell Surface Expression of Receptors for IFN-a and TNF-a on Murine Neuroblastoma Cells and Enhances the Proapoptotic and Overall Antitumor Activity of Systemic Cytokine Therapy in Murine Neuroblastoma Tumors T2 - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AN - 39755259; 4074286 JF - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AU - Khan, Tahira Y1 - 2005/11/10/ PY - 2005 DA - 2005 Nov 10 KW - Cytokines KW - Antitumor activity KW - Proteasomes KW - Neuroblastoma cells KW - Cell surface KW - Neuroblastoma KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39755259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.atitle=Proteasome+Inhibition+Upregulates+the+Cell+Surface+Expression+of+Receptors+for+IFN-a+and+TNF-a+on+Murine+Neuroblastoma+Cells+and+Enhances+the+Proapoptotic+and+Overall+Antitumor+Activity+of+Systemic+Cytokine+Therapy+in+Murine+Neuroblastoma+Tumors&rft.au=Khan%2C+Tahira&rft.aulast=Khan&rft.aufirst=Tahira&rft.date=2005-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/meetings/am05/presentations.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CD4 Cells can be More Efficient at Tumor Rejection than CD8 Cells T2 - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AN - 39752385; 4074311 JF - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AU - Perez-Diez, Ainhoa Y1 - 2005/11/10/ PY - 2005 DA - 2005 Nov 10 KW - CD8 antigen KW - CD4 antigen KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39752385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.atitle=CD4+Cells+can+be+More+Efficient+at+Tumor+Rejection+than+CD8+Cells&rft.au=Perez-Diez%2C+Ainhoa&rft.aulast=Perez-Diez&rft.aufirst=Ainhoa&rft.date=2005-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/meetings/am05/presentations.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phase I Trial of Siplizumab in CD2-Positive Lymphoproliferative Disease T2 - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AN - 39752336; 4074300 JF - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AU - Janik, John Y1 - 2005/11/10/ PY - 2005 DA - 2005 Nov 10 KW - Immunoproliferative diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39752336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.atitle=Phase+I+Trial+of+Siplizumab+in+CD2-Positive+Lymphoproliferative+Disease&rft.au=Janik%2C+John&rft.aulast=Janik&rft.aufirst=John&rft.date=2005-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/meetings/am05/presentations.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expansion of CD4 + CD25 + Regulatory T Cells During Lymphopenia and Following IL2 Therapy T2 - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AN - 39752290; 4074298 JF - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AU - Mackall, Crystal Y1 - 2005/11/10/ PY - 2005 DA - 2005 Nov 10 KW - Interleukin 2 KW - Lymphocytes T KW - Immunoregulation KW - CD25 antigen KW - CD4 antigen KW - Lymphopenia KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39752290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.atitle=Expansion+of+CD4+%2B+CD25+%2B+Regulatory+T+Cells+During+Lymphopenia+and+Following+IL2+Therapy&rft.au=Mackall%2C+Crystal&rft.aulast=Mackall&rft.aufirst=Crystal&rft.date=2005-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/meetings/am05/presentations.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tumor Therapy with Proteasome Inhibitor Bortezomib (Velcade, PS- 341) Plus Death Receptor (DR5) Agonist Antibody MD5.1 T2 - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AN - 39741274; 4074283 JF - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AU - Shanker, Anil Y1 - 2005/11/10/ PY - 2005 DA - 2005 Nov 10 KW - Mortality KW - Antibodies KW - Proteasome inhibitors KW - Death receptors KW - Therapy KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39741274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.atitle=Tumor+Therapy+with+Proteasome+Inhibitor+Bortezomib+%28Velcade%2C+PS-+341%29+Plus+Death+Receptor+%28DR5%29+Agonist+Antibody+MD5.1&rft.au=Shanker%2C+Anil&rft.aulast=Shanker&rft.aufirst=Anil&rft.date=2005-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/meetings/am05/presentations.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - How Host Cells Sink Anti-Tumor Responses by Competing for Activating Cytokines T2 - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AN - 39741169; 4074277 JF - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AU - Restifo, Nicholas P Y1 - 2005/11/10/ PY - 2005 DA - 2005 Nov 10 KW - Cytokines KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39741169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.atitle=How+Host+Cells+Sink+Anti-Tumor+Responses+by+Competing+for+Activating+Cytokines&rft.au=Restifo%2C+Nicholas+P&rft.aulast=Restifo&rft.aufirst=Nicholas&rft.date=2005-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/meetings/am05/presentations.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Making Vaccines Work: Translating Basic and Preclinical Immunology into Human Immunotherapies T2 - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AN - 39695322; 4074334 JF - 20th Annual Meeting of the International Society for Biological Therapy of Cancer AU - Restifo, Nicholas P Y1 - 2005/11/10/ PY - 2005 DA - 2005 Nov 10 KW - Vaccines KW - Immunology KW - Immunotherapy KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39695322?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.atitle=Making+Vaccines+Work%3A+Translating+Basic+and+Preclinical+Immunology+into+Human+Immunotherapies&rft.au=Restifo%2C+Nicholas+P&rft.aulast=Restifo&rft.aufirst=Nicholas&rft.date=2005-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Meeting+of+the+International+Society+for+Biological+Therapy+of+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.isbtc.org/meetings/am05/presentations.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Epigenetic mechanisms and gene networks in the nervous system. AN - 68786583; 16280577 JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Colvis, Christine M AU - Pollock, Jonathan D AU - Goodman, Richard H AU - Impey, Soren AU - Dunn, John AU - Mandel, Gail AU - Champagne, Frances A AU - Mayford, Mark AU - Korzus, Edward AU - Kumar, Arvind AU - Renthal, William AU - Theobald, David E H AU - Nestler, Eric J AD - Division of Basic Neurosciences and Behavioral Research, National Institute on Drug Abuse, Bethesda, Maryland 20892, USA. ccolvis@nida.nih.gov Y1 - 2005/11/09/ PY - 2005 DA - 2005 Nov 09 SP - 10379 EP - 10389 VL - 25 IS - 45 KW - Histones KW - 0 KW - Transcription Factors KW - Index Medicus KW - Environment KW - Animals KW - DNA Methylation KW - Models, Molecular KW - Gene Silencing KW - Neurons KW - Histones -- metabolism KW - Genome KW - Substance-Related Disorders -- genetics KW - Epigenesis, Genetic -- physiology KW - Transcription Factors -- metabolism KW - Chromatin Assembly and Disassembly -- physiology KW - Nervous System UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68786583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Epigenetic+mechanisms+and+gene+networks+in+the+nervous+system.&rft.au=Colvis%2C+Christine+M%3BPollock%2C+Jonathan+D%3BGoodman%2C+Richard+H%3BImpey%2C+Soren%3BDunn%2C+John%3BMandel%2C+Gail%3BChampagne%2C+Frances+A%3BMayford%2C+Mark%3BKorzus%2C+Edward%3BKumar%2C+Arvind%3BRenthal%2C+William%3BTheobald%2C+David+E+H%3BNestler%2C+Eric+J&rft.aulast=Colvis&rft.aufirst=Christine&rft.date=2005-11-09&rft.volume=25&rft.issue=45&rft.spage=10379&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-25 N1 - Date created - 2005-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Thyroid hormone receptor beta mutants: Dominant negative regulators of peroxisome proliferator-activated receptor gamma action. AN - 68778117; 16260719 AB - Thyroid hormone (T3) and peroxisome proliferators have overlapping metabolic effects in the maintenance of lipid homeostasis. Their actions are mediated by their respective receptors: thyroid hormone receptors (TR) and peroxisome proliferator-activated receptors (PPAR). We recently found that a dominantly negative TRbeta mutant (PV) that causes a genetic disease, resistance to thyroid hormone, acts to repress the ligand (troglitazone)-mediated transcriptional activity of PPARgamma in cultured thyroid cells. This finding suggests that TRbeta mutants could crosstalk with PPARgamma-signaling pathways. The present study explored the molecular mechanisms by which PV represses the PPARgamma transcriptional activity. Gel-shift assays show that the PV, similar to wild-type TRbeta, bound to the peroxisome proliferator response element (PPRE) as homodimers and heterodimers with PPARgamma or the retinoid X receptor (RXR), thereby competing with PPARgamma for binding to PPRE and for sequestering RXR. Association of PPRE-bound PV with corepressors [e.g., nuclear receptor corepressor (NCoR)] that led to transcriptional repression was independent of T3 and troglitazone. Chromatin immunoprecipitation assay further demonstrated that, despite the presence of ligands, NCoR was recruited to PPRE-bound PV on a PPARgamma-target gene, the lipoprotein lipase, in vivo, suggesting the dominant action of PV on PPARgamma-mediated transcriptional activity. Thus, the dominant negative action of PV is not limited on the wild-type TRs. The findings that TRbeta mutants affect PPARgamma functions through dominant negative action provide insights into the molecular mechanisms by which TR regulates the PPARgamma-target genes involved in metabolic pathways, lipid homeostasis, and carcinogenesis. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Araki, Osamu AU - Ying, Hao AU - Furuya, Fumihiko AU - Zhu, Xuguang AU - Cheng, Sheue-Yann AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA. Y1 - 2005/11/08/ PY - 2005 DA - 2005 Nov 08 SP - 16251 EP - 16256 VL - 102 IS - 45 SN - 0027-8424, 0027-8424 KW - Chromans KW - 0 KW - PPAR gamma KW - Retinoid X Receptors KW - Thiazolidinediones KW - Thyroid Hormone Receptors beta KW - Transcription Factors KW - Histone Acetyltransferases KW - EC 2.3.1.48 KW - Ncoa1 protein, mouse KW - Nuclear Receptor Coactivator 1 KW - troglitazone KW - I66ZZ0ZN0E KW - Index Medicus KW - Transcription Factors -- physiology KW - Animals KW - Dimerization KW - Mice KW - Retinoid X Receptors -- chemistry KW - Transcriptional Activation KW - Promoter Regions, Genetic KW - Chromans -- pharmacology KW - Cells, Cultured KW - Thiazolidinediones -- pharmacology KW - Response Elements KW - Mutation KW - Signal Transduction KW - Retinoid X Receptors -- metabolism KW - Thyroid Hormone Receptors beta -- physiology KW - Thyroid Hormone Receptors beta -- genetics KW - PPAR gamma -- physiology KW - PPAR gamma -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68778117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Thyroid+hormone+receptor+beta+mutants%3A+Dominant+negative+regulators+of+peroxisome+proliferator-activated+receptor+gamma+action.&rft.au=Araki%2C+Osamu%3BYing%2C+Hao%3BFuruya%2C+Fumihiko%3BZhu%2C+Xuguang%3BCheng%2C+Sheue-Yann&rft.aulast=Araki&rft.aufirst=Osamu&rft.date=2005-11-08&rft.volume=102&rft.issue=45&rft.spage=16251&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-12 N1 - Date created - 2005-11-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Endocr Rev. 1993 Jun;14(3):348-99 [8319599] Trends Endocrinol Metab. 2005 May-Jun;16(4):176-82 [15860414] Dev Biol. 1994 Oct;165(2):654-69 [7958429] J Biol Chem. 1995 Jul 28;270(30):18117-22 [7629123] Biochemistry. 1995 Aug 22;34(33):10591-9 [7544615] Cell. 1995 Dec 15;83(6):841-50 [8521508] Mol Pharmacol. 1996 Feb;49(2):276-87 [8632760] Mol Cell Endocrinol. 1996 Feb 5;116(2):213-21 [8647322] EMBO J. 1996 Oct 1;15(19):5336-48 [8895578] Annu Rev Cell Dev Biol. 1996;12:335-63 [8970730] J Biol Chem. 1997 Apr 4;272(14):9048-54 [9083030] Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13209-14 [11069286] Rev Endocr Metab Disord. 2000 Jan;1(1-2):9-18 [11704997] J Biol Chem. 2002 Jul 26;277(30):26821-30 [12015306] Mol Endocrinol. 2002 Sep;16(9):2077-92 [12198244] Thyroid. 2002 Nov;12(11):963-9 [12490073] Carcinogenesis. 2003 Sep;24(9):1467-79 [12869418] Cancer Res. 2003 Sep 1;63(17):5274-80 [14500358] Endocr Rev. 2004 Feb;25(1):45-71 [14769827] Cell. 1987 Nov 6;51(3):445-53 [3664642] J Clin Endocrinol Metab. 1991 Nov;73(5):990-4 [1682340] J Clin Invest. 1991 Dec;88(6):2123-30 [1661299] Mol Endocrinol. 1992 Feb;6(2):248-58 [1569968] Mol Endocrinol. 1997 Apr;11(4):470-80 [9092799] J Biol Chem. 1997 Aug 8;272(32):20108-17 [9242684] Endocrinology. 1998 Feb;139(2):640-50 [9449636] Endocr Rev. 1999 Oct;20(5):649-88 [10529898] Genes Dev. 2005 Feb 15;19(4):453-61 [15681609] J Biol Chem. 1994 Apr 22;269(16):11683-6 [8163464] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The ETV6-NTRK3 chimeric tyrosine kinase suppresses TGF-beta signaling by inactivating the TGF-beta type II receptor. AN - 68776049; 16258068 AB - An emerging theme in cancer biology is that although some malignancies occur through the sequential acquisition of different genetic alterations, certain dominantly acting oncoproteins such as those associated with chromosomal translocations have multiple functions and do not require additional mutations for cell transformation. The ETV6-NTRK3 (EN) chimeric tyrosine kinase, a potent oncoprotein expressed in tumors derived from multiple cell lineages, functions as a constitutively active protein tyrosine kinase. Here, we show that EN suppresses TGF-beta signaling by directly binding to the type II TGF-beta receptor, thereby preventing it from interacting with the type I TGF-beta receptor. This activity requires a functional EN protein tyrosine kinase, and type II TGF-beta receptor appears to be a direct target of EN. Our findings provide evidence for a previously undescribed mechanism by which oncogenic tyrosine kinases can block TGF-beta tumor suppressor activity. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Jin, Wook AU - Kim, Byung-Chul AU - Tognon, Cristina AU - Lee, Ho-Jae AU - Patel, Sejal AU - Lannon, Chris L AU - Maris, John M AU - Triche, Timothy J AU - Sorensen, Poul H B AU - Kim, Seong-Jin AD - Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, MD 20892-5055, USA. Y1 - 2005/11/08/ PY - 2005 DA - 2005 Nov 08 SP - 16239 EP - 16244 VL - 102 IS - 45 SN - 0027-8424, 0027-8424 KW - ETV6-NTRK3 fusion protein, human KW - 0 KW - Oncogene Proteins, Fusion KW - Receptors, Transforming Growth Factor beta KW - Smad2 Protein KW - Smad3 Protein KW - Transforming Growth Factor beta KW - TGF-beta type I receptor KW - EC 2.7.1.11 KW - Protein-Serine-Threonine Kinases KW - EC 2.7.11.1 KW - Activin Receptors, Type I KW - EC 2.7.11.30 KW - transforming growth factor-beta type II receptor KW - Index Medicus KW - Animals KW - Smad2 Protein -- metabolism KW - Phosphorylation KW - Activin Receptors, Type I -- physiology KW - Humans KW - Smad3 Protein -- metabolism KW - Molecular Sequence Data KW - Mice KW - Amino Acid Sequence KW - NIH 3T3 Cells KW - Cell Transformation, Neoplastic KW - Signal Transduction -- physiology KW - Oncogene Proteins, Fusion -- physiology KW - Receptors, Transforming Growth Factor beta -- physiology KW - Receptors, Transforming Growth Factor beta -- antagonists & inhibitors KW - Transforming Growth Factor beta -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68776049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=The+ETV6-NTRK3+chimeric+tyrosine+kinase+suppresses+TGF-beta+signaling+by+inactivating+the+TGF-beta+type+II+receptor.&rft.au=Jin%2C+Wook%3BKim%2C+Byung-Chul%3BTognon%2C+Cristina%3BLee%2C+Ho-Jae%3BPatel%2C+Sejal%3BLannon%2C+Chris+L%3BMaris%2C+John+M%3BTriche%2C+Timothy+J%3BSorensen%2C+Poul+H+B%3BKim%2C+Seong-Jin&rft.aulast=Jin&rft.aufirst=Wook&rft.date=2005-11-08&rft.volume=102&rft.issue=45&rft.spage=16239&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-12 N1 - Date created - 2005-11-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell. 1992 Dec 11;71(6):1003-14 [1333888] Cell. 1992 Feb 21;68(4):775-85 [1310899] EMBO J. 1995 May 15;14(10):2199-208 [7774578] Nat Genet. 1998 Feb;18(2):184-7 [9462753] Mol Cell. 1998 Mar;1(4):611-7 [9660945] J Biol Chem. 1998 Aug 14;273(33):21145-52 [9694870] Mol Cell. 1998 Jul;2(1):109-20 [9702197] Am J Pathol. 1998 Nov;153(5):1451-8 [9811336] Cancer Res. 1998 Nov 15;58(22):5046-8 [9823307] Blood. 1999 Feb 15;93(4):1355-63 [9949179] BJU Int. 1999 Sep;84(4):495-502 [10468769] Clin Cancer Res. 1999 Aug;5(8):2205-12 [10473107] Oncogene. 2000 Feb 17;19(7):906-15 [10702799] EMBO J. 2000 Apr 17;19(8):1827-38 [10775267] J Natl Cancer Inst. 2000 Sep 6;92(17):1388-402 [10974075] Cancer Res. 2001 Dec 15;61(24):8909-16 [11751416] Cytokine Growth Factor Rev. 2002 Feb;13(1):11-7 [11750876] Cancer Cell. 2002 Mar;1(2):117-23 [12086869] Oncogene. 2002 Aug 22;21(37):5684-95 [12173038] Cancer Cell. 2002 Nov;2(5):367-76 [12450792] Science. 2003 May 9;300(5621):949 [12738854] Cell. 2003 Jun 13;113(6):685-700 [12809600] Leukemia. 2003 Sep;17(9):1731-7 [12970772] Nature. 2003 Oct 9;425(6958):577-84 [14534577] J Biol Chem. 2004 Feb 20;279(8):6225-34 [14668342] Mol Cell Biol. 2004 Jun;24(11):4636-50 [15143160] Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12867-71 [7809137] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nucleoid remodeling by an altered HU protein: Reorganization of the transcription program AN - 19395313; 7144985 AB - Bacterial nucleoid organization is believed to have minimal influence on the global transcription program. Using an altered bacterial histone-like protein, HU alpha , we show that reorganization of the nucleoid configuration can dynamically modulate the cellular transcription pattern. The mutant protein transformed the loosely packed nucleoid into a densely condensed structure. The nucleoid compaction, coupled with increased global DNA supercoiling, generated radical changes in the morphology, physiology, and metabolism of wild-type K-12 Escherichia coli. Many constitutive housekeeping genes involved in nutrient utilization were repressed, whereas many quiescent genes associated with virulence were activated in the mutant. We propose that, as in eukaryotes, the nucleoid architecture dictates the global transcription profile and, consequently, the behavior pattern in bacteria. JF - Proceedings of the National Academy of Sciences, USA AU - Kar, Sudeshna AU - Edgar, Rotem AU - Adhya, Sankar AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264 Y1 - 2005/11/08/ PY - 2005 DA - 2005 Nov 08 SP - 16397 EP - 16402 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 102 IS - 45 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Virulence KW - Supercoiling KW - Escherichia coli KW - DNA KW - Transcription KW - Nucleoids KW - double prime HU protein KW - Nutrient utilization KW - Compaction KW - Metabolism KW - Radicals KW - J 02330:Biochemistry KW - N 14835:Protein-Nucleic Acids Association UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19395313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Nucleoid+remodeling+by+an+altered+HU+protein%3A+Reorganization+of+the+transcription+program&rft.au=Kar%2C+Sudeshna%3BEdgar%2C+Rotem%3BAdhya%2C+Sankar&rft.aulast=Kar&rft.aufirst=Sudeshna&rft.date=2005-11-08&rft.volume=102&rft.issue=45&rft.spage=16397&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Virulence; Supercoiling; DNA; Transcription; Nucleoids; Nutrient utilization; double prime HU protein; Compaction; Metabolism; Radicals; Escherichia coli ER - TY - JOUR T1 - Inhibition of mitochondrial aldehyde dehydrogenase by nitric oxide-mediated S-nitrosylation. AN - 68763885; 16242127 AB - Mitochondrial aldehyde dehydrogenase (ALDH2) is responsible for the metabolism of acetaldehyde and other toxic lipid aldehydes. Despite many reports about the inhibition of ALDH2 by toxic chemicals, it is unknown whether nitric oxide (NO) can alter the ALDH2 activity in intact cells or in vivo animals. The aim of this study was to investigate the effects of NO on ALDH2 activity in H4IIE-C3 rat hepatoma cells. NO donors such as S-nitrosoglutathione (GSNO), S-nitroso-N-acetylpenicillamine, and 3-morpholinosydnonimine significantly increased the nitrite concentration while they inhibited the ALDH2 activity. Addition of GSH-ethylester (GSH-EE) completely blocked the GSNO-mediated ALDH2 inhibition and increased nitrite concentration. To directly demonstrate the NO-mediated S-nitrosylation and inactivation, ALDH2 was immunopurified from control or GSNO-treated cells and subjected to immunoblot analysis. The anti-nitrosocysteine antibody recognized the immunopurified ALDH2 only from the GSNO-treated samples. All these results indicate that S-nitrosylation of ALDH2 in intact cells leads to reversible inhibition of ALDH2 activity. JF - FEBS letters AU - Moon, Kwan-Hoon AU - Kim, Bong-Jo AU - Song, Byoung J AD - Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892-9410, USA. Y1 - 2005/11/07/ PY - 2005 DA - 2005 Nov 07 SP - 6115 EP - 6120 VL - 579 IS - 27 SN - 0014-5793, 0014-5793 KW - Antibodies KW - 0 KW - Mitochondrial Proteins KW - Nitric Oxide Donors KW - Nitrites KW - Nitric Oxide KW - 31C4KY9ESH KW - S-Nitrosoglutathione KW - 57564-91-7 KW - linsidomine KW - 5O5U71P6VQ KW - S-Nitroso-N-Acetylpenicillamine KW - 79032-48-7 KW - Molsidomine KW - D46583G77X KW - Aldehyde Dehydrogenase KW - EC 1.2.1.3 KW - Aldehyde Dehydrogenase, Mitochondrial KW - Aldh2 protein, rat KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Rats KW - S-Nitroso-N-Acetylpenicillamine -- pharmacology KW - Nitrites -- analysis KW - Antibodies -- immunology KW - Animals KW - Cysteine -- metabolism KW - Tumor Cells, Cultured KW - S-Nitrosoglutathione -- pharmacology KW - Molsidomine -- analogs & derivatives KW - Molsidomine -- pharmacology KW - Nitric Oxide Donors -- pharmacology KW - Mitochondria -- enzymology KW - Aldehyde Dehydrogenase -- immunology KW - Mitochondria -- drug effects KW - Mitochondrial Proteins -- antagonists & inhibitors KW - Nitric Oxide -- metabolism KW - Aldehyde Dehydrogenase -- antagonists & inhibitors KW - Aldehyde Dehydrogenase -- analysis KW - Mitochondrial Proteins -- analysis KW - Mitochondrial Proteins -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68763885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+letters&rft.atitle=Inhibition+of+mitochondrial+aldehyde+dehydrogenase+by+nitric+oxide-mediated+S-nitrosylation.&rft.au=Moon%2C+Kwan-Hoon%3BKim%2C+Bong-Jo%3BSong%2C+Byoung+J&rft.aulast=Moon&rft.aufirst=Kwan-Hoon&rft.date=2005-11-07&rft.volume=579&rft.issue=27&rft.spage=6115&rft.isbn=&rft.btitle=&rft.title=FEBS+letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-23 N1 - Date created - 2005-11-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Pharmacol. 2001 Mar 1;61(5):537-45 [11239496] Sci STKE. 2001 Jun 12;2001(86):re1 [11752656] Int J Cancer. 2002 Jan 10;97(2):261-5 [11774273] Free Radic Biol Med. 2002 Feb 15;32(4):350-9 [11841925] Mol Pharmacol. 2003 Feb;63(2):401-8 [12527812] Toxicol Lett. 2003 Oct 15;144(3):279-88 [12927346] Alcohol. 2003 Aug-Oct;31(1-2):19-24 [14615007] J Clin Invest. 2004 Feb;113(3):352-4 [14755331] J Clin Invest. 2004 Feb;113(3):482-9 [14755345] Biochem Pharmacol. 2004 Jun 1;67(11):2167-74 [15135311] J Biol Chem. 2004 May 21;279(21):21749-58 [15031298] Biochem Pharmacol. 1981 Dec 15;30(24):3265-75 [7034733] Anal Biochem. 1982 Oct;126(1):131-8 [7181105] Toxicol Appl Pharmacol. 1983 Feb;67(2):159-65 [6836571] Arch Biochem Biophys. 1985 Jan;236(1):36-46 [3966800] Hepatology. 1985 Mar-Apr;5(2):260-3 [3979959] Alcohol. 1987 Sep-Oct;4(5):413-8 [3675864] J Biol Chem. 1989 Feb 25;264(6):3568-72 [2914964] Hepatology. 1991 Apr;13(4):728-34 [2010168] Free Radic Biol Med. 1991;11(1):81-128 [1937131] Hepatology. 1991 Nov;14(5):798-801 [1937384] J Biol Chem. 1993 Aug 25;268(24):17878-82 [8349672] Arch Biochem Biophys. 1995 Jan 10;316(1):197-205 [7840616] Biochemistry. 1995 Feb 28;34(8):2592-8 [7873540] J Biol Chem. 1995 Jul 14;270(28):16487-90 [7622447] Biochemistry. 1995 Sep 12;34(36):11494-9 [7547878] Alcohol Clin Exp Res. 1995 Dec;19(6):1414-9 [8749803] Toxicol Appl Pharmacol. 1996 Nov;141(1):299-307 [8917703] Alcohol. 1997 Mar-Apr;14(2):181-9 [9085720] Hepatology. 1997 Jun;25(6):1418-24 [9185762] Hepatology. 1997 Dec;26(6):1386-92 [9397975] Carcinogenesis. 1998 Aug;19(8):1383-7 [9744533] J Biol Chem. 1999 Apr 2;274(14):9427-30 [10092623] Proteomics. 2004 Nov;4(11):3401-12 [15449375] Nat Rev Mol Cell Biol. 2005 Feb;6(2):150-66 [15688001] J Biol Chem. 2005 Feb 4;280(5):3125-8 [15590625] Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12159-64 [16103363] J Hepatol. 1999 Nov;31(5):887-94 [10580587] Mol Pharmacol. 2000 Sep;58(3):535-41 [10953046] Arch Biochem Biophys. 2000 Dec 1;384(1):81-7 [11147839] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Ultrasound, a Tool for Detection of Cardiotoxicity T2 - 2005 Annual Meeting of the American College of Toxicology AN - 39693341; 4038894 JF - 2005 Annual Meeting of the American College of Toxicology AU - Johnson, Kennita Y1 - 2005/11/06/ PY - 2005 DA - 2005 Nov 06 KW - Ultrasound KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39693341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Meeting+of+the+American+College+of+Toxicology&rft.atitle=Ultrasound%2C+a+Tool+for+Detection+of+Cardiotoxicity&rft.au=Johnson%2C+Kennita&rft.aulast=Johnson&rft.aufirst=Kennita&rft.date=2005-11-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Meeting+of+the+American+College+of+Toxicology&rft.issn=&rft_id=info:doi/ L2 - http://www.actox.org/attmtg/PROGRAM05a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Calindol, a positive allosteric modulator of the human Ca(2+) receptor, activates an extracellular ligand-binding domain-deleted rhodopsin-like seven-transmembrane structure in the absence of Ca(2+). AN - 68740969; 16135510 AB - The extracellular calcium-sensing human Ca(2+) receptor (hCaR),2 a member of the family-3 G-protein-coupled receptors (GPCR) possesses a large amino-terminal extracellular ligand-binding domain (ECD) in addition to a seven-transmembrane helical domain (7TMD) characteristic of all GPCRs. Two calcimimetic allosteric modulators, NPS R-568 and Calindol ((R)-2-{1-(1-naphthyl)ethyl-aminom-ethyl}indole), that bind the 7TMD of the hCaR have been reported to potentiate Ca(2+) activation without independently activating the wild type receptor. Because agonists activate rhodopsin-like family-1 GPCRs by binding within the 7TMD, we examined the ability of Calindol, a novel chemically distinct calcimimetic, to activate a Ca(2+) receptor construct (T903-Rhoc) in which the ECD and carboxyl-terminal tail have been deleted to produce a rhodopsin-like 7TMD. Here we report that although Calindol has little or no agonist activity in the absence of extracellular Ca(2+) for the ECD-containing wild type or carboxyl-terminal deleted receptors, it acts as a strong agonist of the T903-Rhoc. In addition, Ca(2+) alone displays little or no agonist activity for the hCaR 7TMD, but potentiates the activation by Calindol. We confirm that activation of Ca(2+) T903-Rhoc by Calindol truly the is independent using in vitro reconstitution with purified G(q). These findings demonstrate distinct allosteric linkages between Ca(2+) site(s) in the ECD and 7TMD and the 7TMD site(s) for calcimimetics. JF - The Journal of biological chemistry AU - Ray, Kausik AU - Tisdale, Justin AU - Dodd, Robert H AU - Dauban, Philippe AU - Ruat, Martial AU - Northup, John K AD - Laboratory of Cellular Biology, NIDCD, National Institutes of Health, Bethesda, Maryland 20892, USA. rayk@nidcd.nih.gov Y1 - 2005/11/04/ PY - 2005 DA - 2005 Nov 04 SP - 37013 EP - 37020 VL - 280 IS - 44 SN - 0021-9258, 0021-9258 KW - (R)-2-(1-(1-naphthyl)ethyl-aminom-ethyl)indole KW - 0 KW - Aniline Compounds KW - Indoles KW - Ligands KW - Membrane Proteins KW - N-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylamine KW - Naphthalenes KW - Phenethylamines KW - Propylamines KW - RHOC protein, human KW - Receptors, Calcium-Sensing KW - Rhodopsin KW - 9009-81-8 KW - rho GTP-Binding Proteins KW - EC 3.6.5.2 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Kidney -- metabolism KW - Aniline Compounds -- pharmacology KW - Membrane Proteins -- chemistry KW - Humans KW - Membrane Proteins -- metabolism KW - Calcium -- pharmacology KW - Mutagenesis, Site-Directed KW - Calcium -- agonists KW - Cells, Cultured KW - Protein Structure, Tertiary KW - rho GTP-Binding Proteins -- metabolism KW - Sequence Deletion KW - Naphthalenes -- pharmacology KW - Receptors, Calcium-Sensing -- chemistry KW - Receptors, Calcium-Sensing -- genetics KW - Receptors, Calcium-Sensing -- metabolism KW - Indoles -- pharmacology KW - Allosteric Regulation KW - Rhodopsin -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68740969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Calindol%2C+a+positive+allosteric+modulator+of+the+human+Ca%282%2B%29+receptor%2C+activates+an+extracellular+ligand-binding+domain-deleted+rhodopsin-like+seven-transmembrane+structure+in+the+absence+of+Ca%282%2B%29.&rft.au=Ray%2C+Kausik%3BTisdale%2C+Justin%3BDodd%2C+Robert+H%3BDauban%2C+Philippe%3BRuat%2C+Martial%3BNorthup%2C+John+K&rft.aulast=Ray&rft.aufirst=Kausik&rft.date=2005-11-04&rft.volume=280&rft.issue=44&rft.spage=37013&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-28 N1 - Date created - 2005-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Binding of Escherichia coli Hemolysin and Activation of the Target Cells Is Not Receptor-dependent AN - 17660554; 6503661 AB - Production of a single cysteine substitution mutant, S177C, allowed Escherichia coli hemolysin (HlyA) to be radioactively labeled with tritiated N-ethylmaleimide without affecting biological activity. It thus became possible to study the binding characteristics of HlyA as well as of toxin mutants in which one or both acylation sites were deleted. All toxins bound to erythrocytes and granulocytes in a nonsaturable manner. Only wild-type toxin and the lytic monoacylated mutant stimulated production of superoxide anions in granulocytes. An oxidative burst coincided with elevation of intracellular Ca super(2+), which was likely because of passive influx of Ca super(2+) through the toxin pores. Competition experiments showed that binding to the cells was receptor-independent, and preloading of cells with a nonlytic HlyA mutant did not abrogate the respiratory burst provoked by a subsequent application of wild-type HlyA. In contrast to a previous report, expression or activation of the beta sub(2) integrin lymphocyte function-associated antigen-1 did not affect binding of HlyA. We conclude that HlyA binds nonspecifically to target cells and a receptor is involved neither in causing hemolysis nor in triggering cellular reactions. JF - Journal of Biological Chemistry AU - Valeva, Angela AU - Walev, Ivan AU - Kemmer, Helene AU - Weis, Silvia AU - Siegel, Isabel AU - Boukhallouk, Fatima AU - Wassenaar, Trudy M AU - Chavakis, Triantafyllos AU - Bhakdi, Sucharit AD - Institute of Medical Microbiology and Hygiene, University of Mainz, D-55101 Mainz, Germany, Molecular Microbiology and Genomics Consultants 55576, Zotzenheim, Germany, and Experimental Immunology Branch, NCI, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2005/11/04/ PY - 2005 DA - 2005 Nov 04 SP - 36657 EP - 36663 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 280 IS - 44 SN - 0021-9258, 0021-9258 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - G 07240:Immunogenetics KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17660554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Binding+of+Escherichia+coli+Hemolysin+and+Activation+of+the+Target+Cells+Is+Not+Receptor-dependent&rft.au=Valeva%2C+Angela%3BWalev%2C+Ivan%3BKemmer%2C+Helene%3BWeis%2C+Silvia%3BSiegel%2C+Isabel%3BBoukhallouk%2C+Fatima%3BWassenaar%2C+Trudy+M%3BChavakis%2C+Triantafyllos%3BBhakdi%2C+Sucharit&rft.aulast=Valeva&rft.aufirst=Angela&rft.date=2005-11-04&rft.volume=280&rft.issue=44&rft.spage=36657&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Quantitative Lingual, Pharyngeal and Laryngeal Ultrasonography in Swallowing Research: A Technical Review AN - 85624069; 200513279 AB - Because of its distinct advantage in radiation-free soft tissue imaging, ultrasonography has been widely used to study lingual, pharyngeal, hyoid, laryngeal, & even esophageal action during swallowing in individuals of all ages. Qualitative ultrasonographic observations have made considerable contributions to our understanding of deglutition. Quantitative ultrasonographic swallowing research has also grown by leaps & bounds over the years with advances in imaging technologies & analytical methodologies. As a technical primer for new investigators, this paper reviews the modern methods for quantitative analysis in ultrasonographic swallowing research. The intended outcome is a basic understanding of the application of ultrasonography with various analysis options to the quantitative study of the deglutitive action of selected upper aerodigestive structures. Though proven useful for swallowing research, ultrasonography has inherent limitations & methodological issues. Future technological advancement & sophisticated image processing & analysis algorithms will resolve some of these issues. Figures, References. Adapted from the source document JF - Clinical Linguistics & Phonetics AU - Chi-Fishman, Gloria AD - National Instit Health, Bethesda, MD gcf@nih.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 589 EP - 604 VL - 19 IS - 6-7 SN - 0269-9206, 0269-9206 KW - Articulatory Measurement Techniques (04730) KW - Oral Cavity (61200) KW - Vocal Tract (94900) KW - Phonation Structures (64550) KW - Research Design (72950) KW - article KW - 6210: hearing and speech physiology; hearing and speech physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85624069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Linguistics+%26+Phonetics&rft.atitle=Quantitative+Lingual%2C+Pharyngeal+and+Laryngeal+Ultrasonography+in+Swallowing+Research%3A+A+Technical+Review&rft.au=Chi-Fishman%2C+Gloria&rft.aulast=Chi-Fishman&rft.aufirst=Gloria&rft.date=2005-11-01&rft.volume=19&rft.issue=6-7&rft.spage=589&rft.isbn=&rft.btitle=&rft.title=Clinical+Linguistics+%26+Phonetics&rft.issn=02699206&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2012-03-01 N1 - Last updated - 2016-09-27 N1 - CODEN - CLLPEZ N1 - SubjectsTermNotLitGenreText - Phonation Structures (64550); Oral Cavity (61200); Articulatory Measurement Techniques (04730); Research Design (72950); Vocal Tract (94900) ER - TY - JOUR T1 - Clinical prognostic factors in malignant parotid gland tumors. AN - 85391989; pmid-16274796 AB - To analyze the factors in parotid malignant epithelial tumors influencing recurrences and disease-specific survival.We retrospectively reviewed the files of 150 patients treated at our institution, from 1974 to 1998. Twenty-four patients were not treated by surgery and were excluded from this study. The remaining 126 patients were treated with surgery and 74 patients had postoperative radiotherapy. Thirty-three patients were treated with parotidectomy plus neck dissection. Neck lymph node metastasis was found in 22 patients, 5 patients had occult neck metastasis, and 4 periparotid lymph nodes metastasis. The mean age was 49 years old. According to the UICC/1997 TNM Classification, 49 patients were stage I, 27 stage II, 22 stage III, and 28 stage IV. The influence of selected factors on the 10 year disease-specific survival was analyzed using the Kaplan-Meier actuarial method and the log-rank test.Forty patients had mucoepidermoid carcinoma, 18 patients adenocarcinoma NOS, 18 patients acinic cell carcinoma, 15 patients adenoid cystic carcinoma, 11 patients malignant mixed tumor, 11 patients salivary duct carcinoma, and 13 patients other pathology. Twenty-five patients had recurrences: 17 had local recurrences, 4 patients had neck recurrences, and 4 were loco-regional recurrences. Five factors influenced negatively the prognosis: 1) T stage (p.00001), 2) grade (p.00001), 3) + lymph nodes (p.0007), 4) facial nerve dysfunction (p.0001), and 5) age (p.004). Patients with high-grade tumors and high-stage tumors had the worst prognosis according to the multivariate analysis. The 10-year disease-specific survival was 97% for stage I, 81% for stage II, 56% for stage III, and 20% for stage IV.The grade of the tumor and stage were the most important prognostic factor.C. JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery AU - Lima, Roberto A AU - Tavares, Marcos R AU - Dias, Fernando L AU - Kligerman, Jacob AU - Nascimento, Marilene F AU - Barbosa, Mauro M AU - Cernea, Claudio R AU - Soares, Jose R AU - Santos, Izabella C AU - Salviano, Scheylla AD - Department of Head and Neck Surgery, Brazilian National Cancer Institute/INCA, Rio de Janeiro, Brazil. rlimamd@globo.com Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 702 EP - 708 VL - 133 IS - 5 SN - 0194-5998, 0194-5998 KW - Index Medicus KW - National Library of Medicine KW - *Adenocarcinoma: mortality KW - Adenocarcinoma: pathology KW - *Adenocarcinoma: therapy KW - Adolescent KW - Adult KW - Age Factors KW - Aged KW - Aged, 80 and over KW - Child KW - Child, Preschool KW - Cohort Studies KW - Combined Modality Therapy KW - Female KW - Follow-Up Studies KW - Humans KW - Male KW - Middle Aged KW - Multivariate Analysis KW - Neck Dissection: methods KW - *Neoplasm Invasiveness: pathology KW - Neoplasm Staging KW - Parotid Gland: radiation effects KW - Parotid Gland: surgery KW - *Parotid Neoplasms: mortality KW - Parotid Neoplasms: pathology KW - *Parotid Neoplasms: therapy KW - Probability KW - Proportional Hazards Models KW - Radiotherapy, Adjuvant KW - Retrospective Studies KW - Risk Assessment KW - Sex Factors KW - Survival Analysis KW - Time Factors KW - Treatment Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85391989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.atitle=Clinical+prognostic+factors+in+malignant+parotid+gland+tumors.&rft.au=Lima%2C+Roberto+A%3BTavares%2C+Marcos+R%3BDias%2C+Fernando+L%3BKligerman%2C+Jacob%3BNascimento%2C+Marilene+F%3BBarbosa%2C+Mauro+M%3BCernea%2C+Claudio+R%3BSoares%2C+Jose+R%3BSantos%2C+Izabella+C%3BSalviano%2C+Scheylla&rft.aulast=Lima&rft.aufirst=Roberto&rft.date=2005-11-01&rft.volume=133&rft.issue=5&rft.spage=702&rft.isbn=&rft.btitle=&rft.title=Otolaryngology--head+and+neck+surgery+%3A+official+journal+of+American+Academy+of+Otolaryngology-Head+and+Neck+Surgery&rft.issn=01945998&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Inhibition of core histones acetylation by carcinogenic nickel(II) AN - 839694232; 13863789 AB - Nickel, a well-established human carcinogen, was shown to decrease acetylation of histones H4 and H3 in cultured cells. Such a decrease is expected to suppress gene expression. However, nickel is known to not only suppress but also enhance the expression of many genes. So, perhaps, nickel can alter histone acetylation in a more complex way? In a first step of testing this presumption, we examined acetylation status of histones H2A, H2B, H3 and H4, in human (HAE) and rat (NRK) cells exposed to nickel(II) under various conditions. In both cell lines, acetylation of all four histones was down-regulated by nickel(II) in a concentration- and time-dependent manner. Acetylation of histone H2B was suppressed to greater extent than that of the others, with histone H3 being relatively least affected. The analysis of acetylation status of each of the four lysine sites at the N-terminal tail of histone H2B revealed decreases consistent with those observed in the total acetylation patterns, with the K12 and K20 residues being markedly more affected than K5 and K15 residues. Thus, the decrease in acetylation was to some degree site specific. In NRK cells, the observed uniform down-regulation of histone acetylation was consistent with a marked suppression of global gene transcription measured as [ super(3)H]-uridine incorporation into mRNA. However, in HAE cells, global RNA expression was transiently increased (in 24 h) before dropping below control after longer exposure (3 days). In conclusion, the effects of Ni(II) on histone acetylation are inhibitory, with their extent depending on the dose and exposure time. This uniform inhibition, however, is not consistently reflected in global RNA expression that in HAE cells may include both increase and decrease of the expression, clearly indicating the involvement of factors other than histone acetylation. The observed effects may contribute to neoplastic transformation of Ni(II)-exposed cells. JF - Molecular and Cellular Biochemistry AU - Golebiowski, Filip AU - Kasprzak, Kazimierz S AD - Laboratory of Comparative Carcinogenesis, NCI at Frederick, Frederick, MD, 21702-1201, USA, filip@ncifcrf.gov Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 133 EP - 139 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 279 IS - 1-2 SN - 0300-8177, 0300-8177 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Gene expression KW - Transformation KW - Acetylation KW - Histone H4 KW - Nickel KW - Lysine KW - Transcription KW - Histone H2B KW - Carcinogens KW - Histone H3 KW - Histone H2A KW - N 14820:DNA Metabolism & Structure KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/839694232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biochemistry&rft.atitle=Inhibition+of+core+histones+acetylation+by+carcinogenic+nickel%28II%29&rft.au=Golebiowski%2C+Filip%3BKasprzak%2C+Kazimierz+S&rft.aulast=Golebiowski&rft.aufirst=Filip&rft.date=2005-11-01&rft.volume=279&rft.issue=1-2&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Biochemistry&rft.issn=03008177&rft_id=info:doi/10.1007%2Fs11010-005-8285-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-01-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Transformation; Gene expression; Acetylation; Histone H4; Nickel; Transcription; Lysine; Histone H2B; Carcinogens; Histone H3; Histone H2A DO - http://dx.doi.org/10.1007/s11010-005-8285-1 ER - TY - JOUR T1 - The role of copper in development of drug resistance in murine carcinoma. AN - 70163261; 16787340 AB - Multidrug resistance (MDR) is a major obstacle to successful application of cancer chemotherapy and also a basic problem in cancer biology. Studies on the molecular basis of MDR have revealed that a number of proteins over express in multidrug resistant cells viz., multidrug resistant MDR1 gene product P-glycoprotein, the multidrug resistance-associated protein (MRP) and enzymes associated with the glutathione (GSH) metabolism. Decreased expression or altered activity of topoisomerase II has also been implicated in MDR. In the present investigation a number of changes in phase II detoxification parameters have been noticed in drug resistant cells but the novel aspect of the present report is the observation that the metal copper is involved in drug resistance. Although copper plays important roles in many human and other biological systems and even in the treatment of cancer but the relation of Cu and drug resistance has not so far been studied in detailed. The present report describes the novel findings that the level of copper increases with the development of drug resistance in Ehrlich ascites carcinoma and in Lewis lung carcinoma cells and also in serum of mice bearing drug resistant cancer cells compared to mice bearing drug sensitive cells; the work indicates the important aspect of treating drug resistant cancer patients by lowering Cu level in the cancerous cells and serum prior to treatment. JF - Medicinal chemistry (Shariqah (United Arab Emirates)) AU - Majumder, S AU - Dutta, P AU - Choudhuri, S K AD - Department of Environmental Carcinogenesis and Toxicology (ECT), Chittaranjan National Cancer Institute, CNCI, Calcutta-700026, India. Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 563 EP - 573 VL - 1 IS - 6 SN - 1573-4064, 1573-4064 KW - Copper KW - 789U1901C5 KW - Catalase KW - EC 1.11.1.6 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Index Medicus KW - Superoxide Dismutase -- analysis KW - Animals KW - Disease Progression KW - Kidney -- enzymology KW - Superoxide Dismutase -- metabolism KW - Liver -- metabolism KW - Cell Line, Tumor KW - Mice KW - Kidney -- chemistry KW - Liver -- chemistry KW - Catalase -- analysis KW - Structure-Activity Relationship KW - Catalase -- metabolism KW - Male KW - Carcinoma, Lewis Lung -- drug therapy KW - Carcinoma, Lewis Lung -- blood KW - Carcinoma, Ehrlich Tumor -- drug therapy KW - Carcinoma, Lewis Lung -- chemistry KW - Carcinoma, Ehrlich Tumor -- chemistry KW - Drug Resistance, Neoplasm KW - Carcinoma, Ehrlich Tumor -- blood KW - Copper -- blood KW - Copper -- chemistry KW - Drug Resistance, Multiple UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70163261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medicinal+chemistry+%28Shariqah+%28United+Arab+Emirates%29%29&rft.atitle=The+role+of+copper+in+development+of+drug+resistance+in+murine+carcinoma.&rft.au=Majumder%2C+S%3BDutta%2C+P%3BChoudhuri%2C+S+K&rft.aulast=Majumder&rft.aufirst=S&rft.date=2005-11-01&rft.volume=1&rft.issue=6&rft.spage=563&rft.isbn=&rft.btitle=&rft.title=Medicinal+chemistry+%28Shariqah+%28United+Arab+Emirates%29%29&rft.issn=15734064&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-24 N1 - Date created - 2006-06-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The epidemiology of social anxiety disorder in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 69072266; 16420070 AB - To present nationally representative data on 12-month and lifetime prevalence, correlates and comorbidity of social anxiety disorder (SAD) among adults in the United States as determined by the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions. Face-to-face survey. The United States. Adults (aged 18 and over) residing in households and group quarters (N = 43,093). Prevalence and associations of SAD with sociodemographic and psychiatric correlates and Axis I and II disorders. The prevalence of 12-month and lifetime DSM-IV SAD was 2.8% (95% CI = 2.5 to 3.1) and 5.0% (95% CI = 4.6 to 5.4), respectively. Being Native American, being young, or having low income increased risk, while being male, being of Asian, Hispanic, or black race/ethnicity, or living in urban or more populated regions reduced risk. Mean age at onset of SAD was 15.1 years, with a mean duration of 16.3 years. Over 80% of individuals with SAD received no treatment, and the mean age at first treatment was 27.2 years. Current and lifetime SAD were significantly related to other specific psychiatric disorders, most notably generalized anxiety, bipolar I, and avoidant and dependent personality disorders. The mean number of feared social situations among individuals with SAD was 7.0, with the majority reporting anxiety in performance situations. Social anxiety disorder was associated with substantial unremitting course and extremely early age at onset. Social anxiety disorder often goes untreated, underscoring the need for health care initiatives geared toward increasing recognition and treatment. Comprehensive evaluation of patients with SAD should include a systematic assessment of comorbid disorders, and novel approaches to the treatment of comorbid SAD are needed. JF - The Journal of clinical psychiatry AU - Grant, Bridget F AU - Hasin, Deborah S AU - Blanco, Carlos AU - Stinson, Frederick S AU - Chou, S Patricia AU - Goldstein, Rise B AU - Dawson, Deborah A AU - Smith, Sharon AU - Saha, Tulshi D AU - Huang, Boji AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism (NIAAA), NIH/DHHS, 5635 Fishers Lane, Bethesda, MD 20892-9304, USA. bgrant@willco.niaaa.nih.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 1351 EP - 1361 VL - 66 IS - 11 SN - 0160-6689, 0160-6689 KW - Index Medicus KW - Mental Disorders -- therapy KW - Age of Onset KW - Humans KW - Mental Disorders -- epidemiology KW - Aged KW - Mental Disorders -- etiology KW - Comorbidity KW - Ethnic Groups -- statistics & numerical data KW - Mental Disorders -- diagnosis KW - Psychiatric Status Rating Scales KW - Adult KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Female KW - Male KW - Prevalence KW - Alcohol-Related Disorders -- epidemiology KW - Phobic Disorders -- therapy KW - Health Surveys KW - Phobic Disorders -- epidemiology KW - Phobic Disorders -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69072266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=The+epidemiology+of+social+anxiety+disorder+in+the+United+States%3A+results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Grant%2C+Bridget+F%3BHasin%2C+Deborah+S%3BBlanco%2C+Carlos%3BStinson%2C+Frederick+S%3BChou%2C+S+Patricia%3BGoldstein%2C+Rise+B%3BDawson%2C+Deborah+A%3BSmith%2C+Sharon%3BSaha%2C+Tulshi+D%3BHuang%2C+Boji&rft.aulast=Grant&rft.aufirst=Bridget&rft.date=2005-11-01&rft.volume=66&rft.issue=11&rft.spage=1351&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-30 N1 - Date created - 2006-01-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Evid Based Ment Health. 2006 Aug;9(3):88 [16868207] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Immunotherapeutic approaches in ocular inflammatory diseases. AN - 69068467; 16407781 AB - This comprehensive review discusses immunotherapeutic approaches to ocular inflammatory diseases, updates information provided in the literature, and presents clinical experiences with an emphasis on autoimmune uveitis at the National Eye Institute, United States. Current medical and surgical therapeutic approaches, including medications such as corticosteroids, anti-metabolites, alkylating agents, calcineurin and purine synthesis inhibitors, biologics as well as some anti-infectious agents, are reviewed along with new modalities and experimental approaches. Most immunosuppressive therapies have significant adverse effects. Physicians must be familiar with the pharmacology of the available drugs and aware of the philosophies behind the treatment. JF - Archivum immunologiae et therapiae experimentalis AU - Kurup, Shree K AU - Chan, Chi-Chao AD - National Eye Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892-1857, USA. PY - 2005 SP - 484 EP - 496 VL - 53 IS - 6 SN - 0004-069X, 0004-069X KW - Anti-Inflammatory Agents KW - 0 KW - Antimetabolites KW - Calcineurin Inhibitors KW - Glucocorticoids KW - Purines KW - Index Medicus KW - Purines -- metabolism KW - Humans KW - Antimetabolites -- therapeutic use KW - Glucocorticoids -- therapeutic use KW - Plasmapheresis KW - Stem Cell Transplantation KW - Uveitis -- therapy KW - Anti-Inflammatory Agents -- therapeutic use KW - Uveitis -- diagnosis KW - Uveitis -- physiopathology KW - Uveitis -- immunology KW - Immunotherapy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69068467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archivum+immunologiae+et+therapiae+experimentalis&rft.atitle=Immunotherapeutic+approaches+in+ocular+inflammatory+diseases.&rft.au=Kurup%2C+Shree+K%3BChan%2C+Chi-Chao&rft.aulast=Kurup&rft.aufirst=Shree&rft.date=2005-11-01&rft.volume=53&rft.issue=6&rft.spage=484&rft.isbn=&rft.btitle=&rft.title=Archivum+immunologiae+et+therapiae+experimentalis&rft.issn=0004069X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-02 N1 - Date created - 2006-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development of novel anticancer agents in older patients: pharmacokinetic, pharmacodynamic, and other considerations. AN - 69065744; 16393482 AB - The development of novel anticancer agents in older patients presents both challenges and unique opportunities. Intrapatient variability due to comorbid conditions and the use of multiple concomitant medications may overshadow other age-related differences in pharmacokinetics. The increasing interest in oral agents may be especially problematic in older patients who have difficulty with adherence, particularly if the oral agents are given in combination or according to complex schedules. Polypharmacy, chronic comorbid conditions, and impaired organ reserve in the elderly can lead to pharmacodynamic differences such as increased toxicity and, possibly, reduced efficacy. Hampered immune responsiveness is an important area warranting further research. The development of novel agents to treat older patients with cancer cannot be successfully accomplished without increasing the proportion of elderly patients entered into clinical trials. Furthermore, data obtained from studies in older patients may provide valuable information applicable to the development of novel agents in younger patients and to a better understanding of cancer biology and treatment in general. JF - Cancer journal (Sudbury, Mass.) AU - Murgo, Anthony J AU - Espinoza-Delgado, Igor AD - National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA. murgoa@mail.nih.gov PY - 2005 SP - 481 EP - 487 VL - 11 IS - 6 SN - 1528-9117, 1528-9117 KW - Antineoplastic Agents KW - 0 KW - Drugs, Investigational KW - Index Medicus KW - Aged -- physiology KW - Immune System -- drug effects KW - Humans KW - Clinical Trials as Topic KW - Comorbidity KW - Drugs, Investigational -- pharmacokinetics KW - Neoplasms -- drug therapy KW - Drugs, Investigational -- pharmacology KW - Drug Evaluation KW - Antineoplastic Agents -- pharmacokinetics KW - Neoplasms -- epidemiology KW - Drugs, Investigational -- adverse effects KW - Antineoplastic Agents -- pharmacology KW - Neoplasms -- immunology KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69065744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+journal+%28Sudbury%2C+Mass.%29&rft.atitle=Development+of+novel+anticancer+agents+in+older+patients%3A+pharmacokinetic%2C+pharmacodynamic%2C+and+other+considerations.&rft.au=Murgo%2C+Anthony+J%3BEspinoza-Delgado%2C+Igor&rft.aulast=Murgo&rft.aufirst=Anthony&rft.date=2005-11-01&rft.volume=11&rft.issue=6&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=Cancer+journal+%28Sudbury%2C+Mass.%29&rft.issn=15289117&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-30 N1 - Date created - 2006-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Stability regulation of mRNA and the control of gene expression. AN - 69062758; 16394137 AB - Microarray technology has become highly valuable for identifying complex global changes in gene expression patterns. Standard techniques measure changes in total cellular poly(A) mRNA levels. The assumption that changes in gene expression as measured by these techniques are directly and well correlated with changes in rates of new gene synthesis form the basis of attempts to connect coordinated changes in gene expression with shared transcription regulatory elements. Yet systematic attempts at this approach remain difficult to demonstrate convincingly. One reason for this difficulty may result from the intricate convergence of both transcriptional and mRNA turnover events which, together, directly influence steady-state mRNA levels. Recent technical advances have led to the successful scale-up and application of nuclear run-on procedures directly to microarrays. This development has allowed a gene-by-gene comparison between new gene synthesis in the nucleus and measured changes in total cellular polyA mRNA. Results from these studies have begun to challenge the strict interpretation of changes in gene expression measured by conventional microarrays as being closely correlated with changes in mRNA transcription rate, but rather they tend to support the significant expansion of the role played by changes in mRNA stability regulation to standard analyses of gene expression. Gene expression profiles obtained from both polyA mRNA (whole-cell) and nuclear run-on (newly transcribed) RNA across a time course of one hour following the activation of human Jurkat T cells with PMA plus ionomycin revealed that regulation of mRNA stability may account for as much as 50% of all measurements of changes in total cellular polyA mRNA in this system. Stability regulation was inferred by the absence of corresponding regulation of nuclear gene transcription activity for groups of genes strongly regulated at the whole cell level and which were also resistant to inhibition by Actinomycin D pre-treatment. Consistent patterns across the time course were observed for both transcribed and stability-regulated genes. It is proposed that the regulation of mRNA stability in response to external stimuli contributes significantly to observed changes in gene expression as measured by high throughput systems. JF - Annals of the New York Academy of Sciences AU - Cheadle, Chris AU - Fan, Jinshui AU - Cho-Chung, Yoon S AU - Werner, Thomas AU - Ray, Jill AU - Do, Lana AU - Gorospe, Myriam AU - Becker, Kevin G AD - Cellular Biochemistry Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. cheadlec@mail.nih.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 196 EP - 204 VL - 1058 SN - 0077-8923, 0077-8923 KW - Phorbol Esters KW - 0 KW - RNA, Messenger KW - Dactinomycin KW - 1CC1JFE158 KW - phorbol-12-myristate KW - 20839-06-9 KW - Ionomycin KW - 56092-81-0 KW - RNA KW - 63231-63-0 KW - Index Medicus KW - Phorbol Esters -- chemistry KW - Dactinomycin -- pharmacology KW - Oligonucleotide Array Sequence Analysis KW - RNA -- metabolism KW - Cell Nucleus -- metabolism KW - Humans KW - Jurkat Cells KW - Gene Expression KW - Transcription, Genetic KW - Ionomycin -- pharmacology KW - Cell Line, Tumor KW - Time Factors KW - RNA, Messenger -- metabolism KW - Gene Expression Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69062758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Stability+regulation+of+mRNA+and+the+control+of+gene+expression.&rft.au=Cheadle%2C+Chris%3BFan%2C+Jinshui%3BCho-Chung%2C+Yoon+S%3BWerner%2C+Thomas%3BRay%2C+Jill%3BDo%2C+Lana%3BGorospe%2C+Myriam%3BBecker%2C+Kevin+G&rft.aulast=Cheadle&rft.aufirst=Chris&rft.date=2005-11-01&rft.volume=1058&rft.issue=&rft.spage=196&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-26 N1 - Date created - 2006-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Methamphetamine-induced neuronal apoptosis involves the activation of multiple death pathways. Review. AN - 68917057; 16371314 AB - The abuse of the illicit drug methamphetamine (METH) is a major concern because it can cause terminal degeneration and neuronal cell death in the brain. METH-induced cell death occurs via processes that resemble apoptosis. In the present review, we discuss the role of various apoptotic events in the causation of METH-induced neuronal apoptosis in vitro and in vivo. Studies using comprehensive approaches to gene expression profiling have allowed for the identification of several genes that are up-regulated or down-regulated after an apoptosis-inducing dose of the drug. Further experiments have also documented the fact that the drug can cause demise of striatal enkephalinergic neurons by cross-talks between mitochondria-, endoplasmic reticulum- and receptor-mediated apoptotic events. These neuropathological observations have also been reported in models of drug-induced neuroplastic alterations used to mimic drug addiction (Nestler, 2001). JF - Neurotoxicity research AU - Cadet, Jean Lud AU - Jayanthi, Subramaniam AU - Deng, Xiaolin AD - Molecular Neuropsychiatry Branch, NIH/NIDA, Intramural Research Program, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. JCADET@intra.nida.nih.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 199 EP - 206 VL - 8 IS - 3-4 SN - 1029-8428, 1029-8428 KW - Central Nervous System Stimulants KW - 0 KW - Transcription Factors KW - Methamphetamine KW - 44RAL3456C KW - Index Medicus KW - Models, Animal KW - Animals KW - Transcription Factors -- metabolism KW - Humans KW - Mitochondria -- drug effects KW - Enzyme Activation -- drug effects KW - Models, Biological KW - Endoplasmic Reticulum -- drug effects KW - Central Nervous System Stimulants -- toxicity KW - Neurons -- drug effects KW - Signal Transduction -- drug effects KW - Neurons -- cytology KW - Apoptosis -- drug effects KW - Methamphetamine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68917057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicity+research&rft.atitle=Methamphetamine-induced+neuronal+apoptosis+involves+the+activation+of+multiple+death+pathways.+Review.&rft.au=Cadet%2C+Jean+Lud%3BJayanthi%2C+Subramaniam%3BDeng%2C+Xiaolin&rft.aulast=Cadet&rft.aufirst=Jean&rft.date=2005-11-01&rft.volume=8&rft.issue=3-4&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Neurotoxicity+research&rft.issn=10298428&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-27 N1 - Date created - 2005-12-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The husbandry and care of dendrobatid frogs. AN - 68911237; 16370573 AB - Dendrobatid frogs are studied primarily for the bioactive alkaloids found in their skin. Also known as poison-dart frogs, these animals accumulate toxic alkaloids from dietary sources. The function and uses of the many alkaloids, the alkaloid accumulation system, and the basic biology and physiology of the frogs themselves are of research interest. Here we overview the taxonomy of these frogs and some of the unique aspects of their natural biology and reproduction. We also describe the components of a successful laboratory housing system, including temperature, lighting, humidity, ventilation, nutrition, health considerations, and handling. A brief summary of dendrobatid research highlights is provided. JF - Contemporary topics in laboratory animal science AU - St Claire, Mark B AU - Kennett, Mary J AU - Thomas, Marvin L AU - Daly, John W AD - Laboratory Animal Science Section and Laboratory of Bioorganic Chemistry, NIDDK, DHHS, NIH, Bethesda, Maryland, USA. Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 8 EP - 14 VL - 44 IS - 6 SN - 1060-0558, 1060-0558 KW - Index Medicus KW - Animals KW - Male KW - Larva -- growth & development KW - Female KW - Environment KW - Animal Nutritional Physiological Phenomena KW - Reproduction -- physiology KW - Animal Husbandry -- methods KW - Housing, Animal KW - Anura -- genetics KW - Anura -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68911237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contemporary+topics+in+laboratory+animal+science&rft.atitle=The+husbandry+and+care+of+dendrobatid+frogs.&rft.au=St+Claire%2C+Mark+B%3BKennett%2C+Mary+J%3BThomas%2C+Marvin+L%3BDaly%2C+John+W&rft.aulast=St+Claire&rft.aufirst=Mark&rft.date=2005-11-01&rft.volume=44&rft.issue=6&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Contemporary+topics+in+laboratory+animal+science&rft.issn=10600558&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-22 N1 - Date created - 2005-12-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Animal models of melanoma. AN - 68907429; 16358815 JF - The journal of investigative dermatology. Symposium proceedings AU - Ha, Linan AU - Noonan, Frances P AU - De Fabo, Edward C AU - Merlino, Glenn AD - Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892, USA. Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 86 EP - 88 VL - 10 IS - 2 SN - 1087-0024, 1087-0024 KW - Hepatocyte Growth Factor KW - 67256-21-7 KW - Index Medicus KW - Animals KW - Humans KW - Mice KW - Mice, Transgenic KW - Hepatocyte Growth Factor -- physiology KW - Ultraviolet Rays KW - Melanoma -- pathology KW - Skin Neoplasms -- etiology KW - Melanoma -- etiology KW - Hepatocyte Growth Factor -- genetics KW - Disease Models, Animal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68907429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+journal+of+investigative+dermatology.+Symposium+proceedings&rft.atitle=Animal+models+of+melanoma.&rft.au=Ha%2C+Linan%3BNoonan%2C+Frances+P%3BDe+Fabo%2C+Edward+C%3BMerlino%2C+Glenn&rft.aulast=Ha&rft.aufirst=Linan&rft.date=2005-11-01&rft.volume=10&rft.issue=2&rft.spage=86&rft.isbn=&rft.btitle=&rft.title=The+journal+of+investigative+dermatology.+Symposium+proceedings&rft.issn=10870024&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-28 N1 - Date created - 2005-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - CLIC4, an intracellular chloride channel protein, is a novel molecular target for cancer therapy. AN - 68905779; 16358817 AB - Chloride intracellular channel (CLIC)4 is a p53- and tumor necrosis factor alpha (TNFalpha)-regulated chloride channel protein that is localized to the mitochondria and cytoplasm of mouse and human keratinocytes. CLIC4 protein increases in differentiating keratinocytes and in keratinocytes exposed to DNA-damaging agents and metabolic inhibitors. Increasing CLIC4 levels by transduction of recombinant CLIC4 causes apoptosis. CLIC4 translocates to the nucleus under a variety of conditions of cell stress, and nuclear CLIC4 is associated with cell cycle arrest and accelerated apoptosis. Reduction of CLIC4 and several other CLIC family members by expressing a doxycycline-regulated CLIC4 antisense also causes apoptosis in squamous cancer cell lines. Expressing antisense CLIC4 in tumors derived from transplanting these cells into nude mice inhibits tumor growth, increases tumor apoptosis, and reduces tumor cell proliferation. Co-administration of TNFalpha intraperitoneally enhances the tumor-inhibitory influence of CLIC4 antisense expression. Together, these results suggest that CLIC4 is important for keratinocyte viability and may be a novel target for anti-cancer therapy. JF - The journal of investigative dermatology. Symposium proceedings AU - Suh, Kwang S AU - Mutoh, Michihiro AU - Gerdes, Michael AU - Yuspa, Stuart H AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-4255, USA. Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 105 EP - 109 VL - 10 IS - 2 SN - 1087-0024, 1087-0024 KW - CLIC4 protein, human KW - 0 KW - Chloride Channels KW - Oligonucleotides, Antisense KW - Index Medicus KW - Animals KW - Humans KW - Keratinocytes -- cytology KW - Cell Differentiation KW - Oligonucleotides, Antisense -- pharmacology KW - Mice KW - Chloride Channels -- physiology KW - Neoplasms -- therapy KW - Chloride Channels -- antagonists & inhibitors KW - Chloride Channels -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68905779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+journal+of+investigative+dermatology.+Symposium+proceedings&rft.atitle=CLIC4%2C+an+intracellular+chloride+channel+protein%2C+is+a+novel+molecular+target+for+cancer+therapy.&rft.au=Suh%2C+Kwang+S%3BMutoh%2C+Michihiro%3BGerdes%2C+Michael%3BYuspa%2C+Stuart+H&rft.aulast=Suh&rft.aufirst=Kwang&rft.date=2005-11-01&rft.volume=10&rft.issue=2&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=The+journal+of+investigative+dermatology.+Symposium+proceedings&rft.issn=10870024&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-28 N1 - Date created - 2005-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Paclitaxel pharmacokinetics and response to chemotherapy in patients with advanced cancer treated with a weekly regimen. AN - 68873709; 16334120 AB - Paclitaxel pharmacokinetics were shown to be related to toxicity and survival. We evaluated the effects of time above paclitaxel concentrations of 0.05 micromol/l (T(>0.05) and systemic exposures (AUC) to total and unbound paclitaxel (tPAC, uPAC) on response in patients with advanced cancer treated with weekly 1-h or 3-h infusions. After 6 weeks of therapy (WOT), 13 out of 21 assessable patients showed either partial response (PR) or stable disease (SD), while 8 had progressive disease (PD). As compared to patients with PD, those with PR or SD showed similar AUCs to uPAC and tPAC but higher (p 0.05). Patients with T(>0.05) > or = 20.7 hours had lower probability (p < 0.05) to progress within 12 WOT. Taking the heterogeneity of the studied tumor types into account, we found T(>0.05) to be associated with response to treatment. This emphasizes the value of threshold models for the investigation of paclitaxel pharmacodynamics. JF - Anticancer research AU - Mielke, Stephan AU - Sparreboom, Alex AU - Behringer, Dirk AU - Mross, Klaus AD - Department of Hematology and Oncology, University of Freiburg Medical Center, Freiburg i. Br., Germany. mielkes@nhlbi.nih.gov PY - 2005 SP - 4423 EP - 4427 VL - 25 IS - 6C SN - 0250-7005, 0250-7005 KW - Antineoplastic Agents, Phytogenic KW - 0 KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Drug Administration Schedule KW - Prospective Studies KW - Infusions, Intravenous KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Peripheral Nervous System Diseases -- chemically induced KW - Male KW - Female KW - Paclitaxel -- administration & dosage KW - Antineoplastic Agents, Phytogenic -- pharmacokinetics KW - Neoplasms -- drug therapy KW - Paclitaxel -- adverse effects KW - Antineoplastic Agents, Phytogenic -- adverse effects KW - Paclitaxel -- pharmacokinetics KW - Antineoplastic Agents, Phytogenic -- administration & dosage KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68873709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anticancer+research&rft.atitle=Paclitaxel+pharmacokinetics+and+response+to+chemotherapy+in+patients+with+advanced+cancer+treated+with+a+weekly+regimen.&rft.au=Mielke%2C+Stephan%3BSparreboom%2C+Alex%3BBehringer%2C+Dirk%3BMross%2C+Klaus&rft.aulast=Mielke&rft.aufirst=Stephan&rft.date=2005-11-01&rft.volume=25&rft.issue=6C&rft.spage=4423&rft.isbn=&rft.btitle=&rft.title=Anticancer+research&rft.issn=02507005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-25 N1 - Date created - 2005-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Loading and unloading: orchestrating centrosome duplication and spindle assembly by Ran/Crm1. AN - 68830100; 16294017 AB - The cell cycle is an intricate process of DNA replication and cell division that concludes with the formation of two genetically equivalent daughter cells. In this progression, the centrosome is duplicated once and only once during the G1/S transition to produce the bipolar spindle and ensure proper chromosome segregation. The presence of multiple centrosomes in cancer cells suggests that this process is mis-regulated during carcinogenesis. This suggests that certain factors exist that license the progression of centrosome duplication and serve to inhibit further duplications during a single cell cycle. Recent studies suggest that the Ran/Crm1 complex not only regulates nucleocytoplasmic transport but is also independently involved in mitotic spindle assembly. Factors that are capable of interacting with Ran/Crm1 through their nuclear export sequences, such as cyclins/cdks, p53 and Brca1/2, may potentially function as centrosome checkpoints akin to the G1/S and G2/M checkpoints of the cell cycle. Our recent findings indicate that nucleophosmin, a protein whose trafficking is mediated by the Ran/Crm1 network, is one of such checkpoint factors for maintaining proper centrosome duplication. We propose that Ran/Crm1 may act as a 'loading dock' to coordinate various checkpoint factors in regulating the fidelity of centrosome duplication during cell cycle progression, and the disruption of these processes may lead to genomic instability and an acceleration of oncogenesis. JF - Cell cycle (Georgetown, Tex.) AU - Budhu, Anuradha S AU - Wang, Xin W AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, NCI, NIH, Bethesda, Maryland 20892-4255, USA. Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 1510 EP - 1514 VL - 4 IS - 11 KW - Cell Cycle Proteins KW - 0 KW - Karyopherins KW - Receptors, Cytoplasmic and Nuclear KW - exportin 1 protein KW - ran GTP-Binding Protein KW - EC 3.6.5.2 KW - Index Medicus KW - Animals KW - Humans KW - Protein Transport -- physiology KW - Cell Cycle Proteins -- physiology KW - Receptors, Cytoplasmic and Nuclear -- physiology KW - Karyopherins -- metabolism KW - Karyopherins -- chemistry KW - ran GTP-Binding Protein -- chemistry KW - ran GTP-Binding Protein -- physiology KW - Cell Cycle Proteins -- metabolism KW - ran GTP-Binding Protein -- metabolism KW - Cell Cycle Proteins -- chemistry KW - Karyopherins -- physiology KW - Receptors, Cytoplasmic and Nuclear -- chemistry KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Centrosome -- physiology KW - Spindle Apparatus -- metabolism KW - Centrosome -- chemistry KW - Spindle Apparatus -- physiology KW - Spindle Apparatus -- chemistry KW - Centrosome -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68830100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+cycle+%28Georgetown%2C+Tex.%29&rft.atitle=Loading+and+unloading%3A+orchestrating+centrosome+duplication+and+spindle+assembly+by+Ran%2FCrm1.&rft.au=Budhu%2C+Anuradha+S%3BWang%2C+Xin+W&rft.aulast=Budhu&rft.aufirst=Anuradha&rft.date=2005-11-01&rft.volume=4&rft.issue=11&rft.spage=1510&rft.isbn=&rft.btitle=&rft.title=Cell+cycle+%28Georgetown%2C+Tex.%29&rft.issn=1551-4005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-12 N1 - Date created - 2005-11-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 2005 Apr 28;352(17):1819-20; author reply 1819-20 [15858195] Nat Cell Biol. 2005 Aug;7(8):823-30 [16041368] Bioessays. 2005 Sep;27(9):884-93 [16108063] Nature. 2005 Sep 1;437(7055):147-53 [16007073] Curr Biol. 1999 Oct 7;9(19):1107-10 [10531007] Cell. 2000 Jan 7;100(1):57-70 [10647931] Cell. 2000 Jan 7;100(1):71-8 [10647932] Genes Dev. 2000 Sep 15;14(18):2277-82 [10995385] Curr Top Dev Biol. 2000;49:267-89 [11005023] Cell. 2000 Sep 29;103(1):127-40 [11051553] Trends Cell Biol. 2001 Jan;11(1):18-21 [11146294] Nature. 2001 Jan 18;409(6818):355-9 [11201745] Breast Cancer Res. 1999;1(1):41-7 [11250682] Nat Cell Biol. 2001 Apr;3(4):433-8 [11283620] Science. 2001 Jun 8;292(5523):1910-5 [11397945] J Biol Chem. 2001 Jun 22;276(25):22797-803 [11287420] Curr Opin Cell Biol. 2002 Feb;14(1):25-34 [11792541] Curr Opin Cell Biol. 2002 Feb;14(1):35-43 [11792542] FEBS Lett. 2002 Jun 19;521(1-3):9-13 [12067716] Nat Cell Biol. 2002 Jul;4(7):529-33 [12080348] Mol Cell. 2002 Sep;10(3):439-40 [12408813] Nat Rev Cancer. 2002 Nov;2(11):815-25 [12415252] Cell Cycle. 2002 Jan;1(1):75-81 [12429912] Cell. 2003 Feb 21;112(4):441-51 [12600309] J Cell Sci. 2003 Aug 15;116(Pt 16):3399-411 [12840069] Mol Cell Biol. 2003 Aug;23(15):5282-92 [12861014] Mol Biol Cell. 2003 Oct;14(10):4260-71 [14517334] Cell. 1989 Feb 10;56(3):379-90 [2914325] Cell. 1992 Nov 13;71(4):587-97 [1423616] Science. 1995 Jan 20;267(5196):316-7 [7824924] Blood. 1996 Feb 1;87(3):882-6 [8562957] Oncogene. 1996 Jan 18;12(2):265-75 [8570204] Science. 1996 Mar 22;271(5256):1744-7 [8596939] Nature. 1996 Jun 20;381(6584):643-4 [8649505] Science. 1996 Dec 6;274(5293):1664-72 [8939848] EMBO J. 1998 May 15;17(10):2728-35 [9582266] Genes Dev. 1998 Jul 15;12(14):2131-43 [9679058] EMBO J. 1999 Mar 15;18(6):1660-72 [10075936] Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3706-11 [10097101] Mol Cell. 1999 Mar;3(3):389-95 [10198641] Oncogene. 1999 May 6;18(18):2892-900 [10362260] Oncogene. 2005 Apr 18;24(17):2909-15 [15838524] Biol Cell. 1999 Jul;91(6):413-27 [10519003] Biol Cell. 1999 Jul;91(6):451-60 [10519005] N Engl J Med. 2005 Jan 20;352(3):254-66 [15659725] Curr Biol. 1999 Apr 22;9(8):429-32 [10226033] Oncogene. 1999 Mar 18;18(11):1935-44 [10208415] Cell. 1999 May 28;97(5):575-86 [10367887] Nat Genet. 1999 Oct;23(2):176-84 [10508513] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Modulating molecular chaperone Hsp90 functions through reversible acetylation. AN - 68817977; 16199163 AB - The molecular chaperone protein Hsp90 is a key regulator of approximately 100 'client' proteins crucial for numerous cell signaling processes. Consequently, understanding the molecular underpinnings that regulate Hsp90 activity is an important biological endeavor. Exciting new results now suggest that, at least for nuclear receptor activity, Hsp90 function is directly regulated by histone deacetylase 6 (HDAC6). These observations have consequences for various biological processes and potentially important implications for the development of cancer therapeutics. JF - Trends in cell biology AU - Aoyagi, Sayura AU - Archer, Trevor K AD - Chromatin and Gene Expression Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, P.O. Box 12233, Research Triangle Park, NC 27709, USA. Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 565 EP - 567 VL - 15 IS - 11 SN - 0962-8924, 0962-8924 KW - HSP90 Heat-Shock Proteins KW - 0 KW - Receptors, Glucocorticoid KW - HDAC6 protein, human KW - EC 3.5.1.98 KW - Hdac6 protein, mouse KW - Histone Deacetylases KW - Index Medicus KW - Animals KW - Acetylation KW - Humans KW - Protein Processing, Post-Translational KW - Mice KW - Receptors, Glucocorticoid -- metabolism KW - Models, Biological KW - Histone Deacetylases -- metabolism KW - HSP90 Heat-Shock Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68817977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+cell+biology&rft.atitle=Modulating+molecular+chaperone+Hsp90+functions+through+reversible+acetylation.&rft.au=Aoyagi%2C+Sayura%3BArcher%2C+Trevor+K&rft.aulast=Aoyagi&rft.aufirst=Sayura&rft.date=2005-11-01&rft.volume=15&rft.issue=11&rft.spage=565&rft.isbn=&rft.btitle=&rft.title=Trends+in+cell+biology&rft.issn=09628924&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-27 N1 - Date created - 2005-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characteristics of metals in nano/ultrafine/fine/coarse particles collected beside a heavily trafficked road. AN - 68804532; 16294844 AB - Fine particles emitted from vehicles have adverse health effects because of their sizes and chemical compositions. Therefore, this study attempted to characterize the metals in nano (0.010 < Dp < 0.056 microm), ultrafine (Dp < 0.1 microm), fine (Dp < 2.5 microm), and coarse (2.5 < Dp < 10 microm) particles collected near a busy road using a microorifice uniform deposition impactor (MOUDI) and a Nano-MOUDI. The nano particles were found to contain more of traffic-related metals (Pb, Cd, Cu, Zn, Ba, and Ni) than particles of other sizes, although crustal metals accounted for over 90% of all the particulate metals. Most crustal metals, Ba, Ni, Pb, and Zn in ultrafine particles displayed Aitken modes due to their local origins. The Ag, Cd, Cr, Ni, Pb, Sb, V, and Zn were 37, 50, 28, 30, 24, 64, 38, and 22% by mass, respectively, in < 0.1-microm particles, with submicron mass median diameters (MMDs) in PM(0.01-18) (except Zn) (particularly the < 0.1-microm MMDs for Cd and Sb). These levels raise potential health issues. Particle-bound Zn was more abundant in the accumulation mode than in the nucleation/condensation mode, but the opposite was true for Ag, Cd, and Sb. The Ag, Ba, Cd, Pb, Sb, V, and Zn contents in nano particles were strongly associated with diesel fuel, while the Cu, Mn, and Sr in particles < 0.1 microm were more strongly associated with gasoline. The high content of Si in nano particles, more associated with diesel soot than with gasoline exhaust, is another health concern. JF - Environmental science & technology AU - Lin, Chih-Chung AU - Chen, Shui-Jen AU - Huang, Kuo-Lin AU - Hwang, Wen-Ing AU - Chang-Chien, Guo-Ping AU - Lin, Wen-Yinn AD - Department of Environmental Engineering and Science, National Pingtung University of Science and Technology, Nei Pu, PingTung 91201, Taiwan. Y1 - 2005/11/01/ PY - 2005 DA - 2005 Nov 01 SP - 8113 EP - 8122 VL - 39 IS - 21 SN - 0013-936X, 0013-936X KW - Air Pollutants KW - 0 KW - Metals KW - Vehicle Emissions KW - Index Medicus KW - Particle Size KW - Air Pollutants -- analysis KW - Air Pollutants -- toxicity KW - Italy KW - Nanotechnology KW - Metals -- chemistry KW - Vehicle Emissions -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68804532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=Characteristics+of+metals+in+nano%2Fultrafine%2Ffine%2Fcoarse+particles+collected+beside+a+heavily+trafficked+road.&rft.au=Lin%2C+Chih-Chung%3BChen%2C+Shui-Jen%3BHuang%2C+Kuo-Lin%3BHwang%2C+Wen-Ing%3BChang-Chien%2C+Guo-Ping%3BLin%2C+Wen-Yinn&rft.aulast=Lin&rft.aufirst=Chih-Chung&rft.date=2005-11-01&rft.volume=39&rft.issue=21&rft.spage=8113&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=0013936X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-03 N1 - Date created - 2005-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interindividual variation in nucleotide excision repair genes and risk of endometrial cancer. AN - 68796140; 16284373 AB - Exposure to estrogens is a likely cause of endometrial cancer, but the means by which estrogens exert this effect are not entirely clear. One hypothesis is that certain estrogen metabolites bind to the DNA, forming bulky adducts that damage the DNA and initiate carcinogenesis. A woman's reduced capacity to repair such damage may increase her risk of endometrial cancer. We conducted a population-based case-control study in western Washington State to address the role of variation in nucleotide excision repair genes on the risk of endometrial cancer. Case women (n = 371), ages 50 to 69 years, were diagnosed with invasive endometrial cancer between 1994 and 1999. Control women (n = 420) were selected using random-digit dialing (ages 50-65 years) and by random selection from Health Care Financing Administration data files (ages 66-69 years). Genotyping assays were done for ERCC1, ERCC2 (XPD), ERCC4 (XPF), ERCC5 (XPG), XPA, and XPC. No appreciable differences between cases and controls were observed in the genotype distributions of ERCC1 (c8092a and c19007t), ERCC2 (D312N, K751Q, and c22541a), ERCC4 (R415Q and t30028c), or ERCC5 (D1104H). Carriage of at least one variant allele for XPA G23A was associated with decreased risk of endometrial cancer [odds ratio (OR), 0.70; 95% confidence interval (95% CI), 0.53-0.93]. Carriage of at least one XPC A499V variant allele was associated with a modest decrease in risk (OR, 0.79; 95% CI, 0.59-1.05). Women with variant alleles at both XPC A499V and K939Q had 58% of the risk of women with no XPC variant alleles (OR, 0.58; 95% CI, 0.35-0.96). Our data suggest that interindividual variation in XPA and XPC influences a woman's risk of endometrial cancer. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Weiss, Jocelyn M AU - Weiss, Noel S AU - Ulrich, Cornelia M AU - Doherty, Jennifer A AU - Voigt, Lynda F AU - Chen, Chu AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Occupational and Environmental Epidemiology Branch, 6120 Executive Boulevard, EPS 8123, MSC 7240, Rockville, MD 20852, USA. weissjoc@mail.nih.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 2524 EP - 2530 VL - 14 IS - 11 Pt 1 SN - 1055-9965, 1055-9965 KW - DNA Adducts KW - 0 KW - DNA-Binding Proteins KW - Index Medicus KW - Genetic Variation KW - DNA Damage KW - Humans KW - Aged KW - Genotype KW - Polymorphism, Restriction Fragment Length KW - Risk Factors KW - Case-Control Studies KW - Middle Aged KW - Genetic Predisposition to Disease KW - Cell Transformation, Neoplastic KW - Female KW - DNA Repair -- genetics KW - DNA-Binding Proteins -- genetics KW - Endometrial Neoplasms -- genetics KW - Endometrial Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68796140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Interindividual+variation+in+nucleotide+excision+repair+genes+and+risk+of+endometrial+cancer.&rft.au=Weiss%2C+Jocelyn+M%3BWeiss%2C+Noel+S%3BUlrich%2C+Cornelia+M%3BDoherty%2C+Jennifer+A%3BVoigt%2C+Lynda+F%3BChen%2C+Chu&rft.aulast=Weiss&rft.aufirst=Jocelyn&rft.date=2005-11-01&rft.volume=14&rft.issue=11+Pt+1&rft.spage=2524&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-11-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):261 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The AUDIT-C: screening for alcohol use disorders and risk drinking in the presence of other psychiatric disorders. AN - 68776638; 16275207 AB - This article examines the performance of the AUDIT-C, as embedded in a large national survey, as a screener for alcohol use disorders (AUDs) and risk drinking among individuals with past-year psychopathology. The analysis is based on data collected in personal interviews from a representative population sample of US adults. The study population consisted of past-year drinkers with any past-year mood disorder (n = 2818), any past-year anxiety disorder (n = 3173), or any personality disorder (n = 4389). Screening performance was evaluated by means of sensitivity, specificity, and areas under receiver operating characteristic curves (AUCs). The AUCs for the AUDIT-C were from 0.888 to 0.893 for alcohol dependence, from 0.864 to 0.876 for any AUD, and from 0.941 to 0.951 for any AUD or risk drinking-all on a par with those observed in the general population. Among men, cut points of either > or =5 or > or =6 points (the former favoring sensitivity and the latter favoring specificity) were optimal for detecting dependence, and cut points of > or =5 points were optimal for any AUD and for any AUD or risk drinking. Among women, a cut point of > or =4 points was optimal for the outcomes of both alcohol dependence and any AUD, whereas a cut point of > or =3 points was preferable for detecting any AUD or risk drinking. JF - Comprehensive psychiatry AU - Dawson, Deborah A AU - Grant, Bridget F AU - Stinson, Frederick S AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-9304, USA. ddawson@mail.nih.gov PY - 2005 SP - 405 EP - 416 VL - 46 IS - 6 SN - 0010-440X, 0010-440X KW - Index Medicus KW - United States KW - Sensitivity and Specificity KW - Risk-Taking KW - Humans KW - Aged KW - Adult KW - Health Surveys KW - Alcohol Drinking -- psychology KW - Middle Aged KW - Adolescent KW - Sex Distribution KW - Female KW - Male KW - Alcoholism -- diagnosis KW - Surveys and Questionnaires KW - Mass Screening -- instrumentation KW - Mental Disorders -- complications KW - Alcoholism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68776638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comprehensive+psychiatry&rft.atitle=The+AUDIT-C%3A+screening+for+alcohol+use+disorders+and+risk+drinking+in+the+presence+of+other+psychiatric+disorders.&rft.au=Dawson%2C+Deborah+A%3BGrant%2C+Bridget+F%3BStinson%2C+Frederick+S&rft.aulast=Dawson&rft.aufirst=Deborah&rft.date=2005-11-01&rft.volume=46&rft.issue=6&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=Comprehensive+psychiatry&rft.issn=0010440X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-16 N1 - Date created - 2005-11-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of (76)Br-FBAU as a PET reporter probe for HSV1-tk gene expression imaging using mouse models of human glioma. AN - 68766432; 16269608 AB - The utility of 5-(76)Br-bromo-2'-fluoro-2'-deoxyuridine ((76)Br-FBAU), a uracil analog, as a PET reporter probe for use with the herpes simplex virus type 1 thymidine kinase (HSV1-tk) reporter gene system for gene expression imaging was evaluated in vivo and in vitro using human and rat glioma cells. Human glioma cell lines U87 and U251 were transduced with replication-defective adenovirus constitutively expressing HSV1-tk (Ad.TK) or a control expressing green fluorescent protein (Ad.GFP). These cells were incubated with (76)Br-FBAU for 20-120 min to determine the percentage of total dose uptake. In vitro uptake of equimolar concentrations (1.8 x 10(-8) mol/L) of (76)Br-FBAU and 2'-fluoro-2'-deoxy-5-iodouracil-beta-d-arabinofuranoside ((14)C-FIAU) was also determined in RG2-TK rat glioma cells stably expressing HSV1-tk and in control RG2 cells at 30-120 min. In vivo uptake of (76)Br-FBAU was determined in subcutaneous U87 tumor intratumorally transduced with Ad.TK by ex vivo biodistribution. Uptake in intracranial U87 tumors transduced with Ad.TK expressing HSV1-tk was measured by brain autoradiography. In vivo PET was performed on subcutaneous and intracranial U87 tumors transduced with Ad.TK and on subcutaneous and intracranial stably expressing RG2-TK tumors. U87 and U251 cells transduced with Ad.TK had significantly increased uptake of (76)Br-FBAU compared with cells transduced with Ad.GFP over 20-120 min. In stably expressing cells at 120 min, (14)C-FIAU uptake in RG2-TK tumor cells was 11.3 %ID (percentage injected dose) and in RG2 control cells was 1.7 %ID, and (76)Br-FBAU uptake in RG2-TK tumor cells was 14.2 %ID and in RG2 control cells was 1.5 %ID. Ex vivo biodistribution of subcutaneous U87 tumors transduced with Ad.TK accumulated (76)Br-FBAU significantly more than in the control Ad.GFP transduced tumor and normal tissue, with the lowest uptake in brain. Autoradiography showed localized uptake in intracranial U87 and U251 cells transduced with Ad.TK. PET image analyses of mice with RG2-TK tumors resulted in an increased tumor-to-background ratio of 13 and 26 from 2 to 6 h after injection, respectively, in intracranial tumors. (76)Br-FBAU accumulates in glioma cells constitutively expressing HSV1-tk by either adenoviral transduction or in stably expressing cell lines both in vitro and in vivo. (76)Br-FBAU shows promise as a PET reporter probe for use with the HSV1-tk in vivo gene expression imaging system. JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine AU - Cho, Steve Y AU - Ravasi, Laura AU - Szajek, Lawrence P AU - Seidel, Jurgen AU - Green, Michael V AU - Fine, Howard A AU - Eckelman, William C AD - NeuroOncology Branch, National Cancer Institute and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 1923 EP - 1930 VL - 46 IS - 11 SN - 0161-5505, 0161-5505 KW - 1-(2-fluoro-2-deoxyarabinofuranosyl)-5-bromouracil KW - 0 KW - Radiopharmaceuticals KW - Recombinant Proteins KW - Viral Proteins KW - Bromouracil KW - 4HK400G5UO KW - thymidine kinase, Canid herpesvirus 1 KW - EC 2.7.1.- KW - Thymidine Kinase KW - EC 2.7.1.21 KW - Index Medicus KW - Radiopharmaceuticals -- pharmacokinetics KW - Animals KW - Humans KW - Disease Models, Animal KW - Metabolic Clearance Rate KW - Mice KW - Mice, Nude KW - Organ Specificity KW - Tissue Distribution KW - Recombinant Proteins -- genetics KW - Radionuclide Imaging KW - Gene Expression Regulation, Neoplastic KW - Recombinant Proteins -- metabolism KW - Genes, Reporter KW - Drug Evaluation, Preclinical KW - Molecular Probe Techniques KW - Viral Proteins -- genetics KW - Transfection -- methods KW - Glioma -- diagnostic imaging KW - Viral Proteins -- metabolism KW - Thymidine Kinase -- metabolism KW - Gene Expression Profiling -- methods KW - Bromouracil -- analogs & derivatives KW - Thymidine Kinase -- genetics KW - Bromouracil -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68766432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.atitle=Evaluation+of+%2876%29Br-FBAU+as+a+PET+reporter+probe+for+HSV1-tk+gene+expression+imaging+using+mouse+models+of+human+glioma.&rft.au=Cho%2C+Steve+Y%3BRavasi%2C+Laura%3BSzajek%2C+Lawrence+P%3BSeidel%2C+Jurgen%3BGreen%2C+Michael+V%3BFine%2C+Howard+A%3BEckelman%2C+William+C&rft.aulast=Cho&rft.aufirst=Steve&rft.date=2005-11-01&rft.volume=46&rft.issue=11&rft.spage=1923&rft.isbn=&rft.btitle=&rft.title=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-03 N1 - Date created - 2005-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cardiac and extracardiac sympathetic denervation in Parkinson's disease with orthostatic hypotension and in pure autonomic failure. AN - 68765353; 16269589 AB - The uptake of 6-(18)F-fluorodopamine by cardiac noradrenergic nerves enables visualization of the sympathetic innervation of the left ventricular myocardium by PET. Patients with Parkinson's disease (PD) and orthostatic hypotension (OH) (PD+OH) or with pure autonomic failure (PAF) have markedly decreased myocardial 6-(18)F-fluorodopamine-derived radioactivity, consistent with cardiac sympathetic denervation, a phenomenon that neurochemical, neuropharmacologic, and, most recently, postmortem neuropathologic studies have confirmed. In this study, we examined whether 6-(18)F-fluorodopamine can visualize sympathetic innervation in extracardiac organs and, if so, whether patients with PD+OH or PAF have neuroimaging evidence of extracardiac noradrenergic denervation. To validate the method, healthy volunteers underwent 6-(18)F-fluorodopamine scanning of the head, thorax, and abdomen, with or without treatment with desipramine to block sympathoneural uptake of catecholamines. (13)N-Ammonia scanning was used to address possible group differences in 6-(18)F-fluorodopamine delivery by blood perfusion. Desipramine treatment was associated with decreased 6-(18)F-fluorodopamine-derived radioactivity in the heart, renal cortex, and thyroid gland but not in the liver, spleen, renal pelvis, or salivary glands. Both the PD+OH group and the PAF group had decreased 6-(18)F-fluorodopamine-derived radioactivity in the heart (P < 0.0001) and renal cortex (P = 0.02 and P = 0.005, respectively). The PD+OH group also had decreased radioactivity in the thyroid gland (P = 0.01). Neither group had decreased radioactivity in the other organs, after correction for (13)N-ammonia-derived radioactivity. 6-(18)F-Fluorodopamine scanning visualizes sympathetic innervation in the heart, renal cortex, and thyroid gland. Both PD+OH and PAF involve decreased noradrenergic innervation that is most prominent in the heart but is also detectable in extracardiac organs. JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine AU - Tipre, Dnyanesh N AU - Goldstein, David S AD - Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. dnyanesht@yahoo.com Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 1775 EP - 1781 VL - 46 IS - 11 SN - 0161-5505, 0161-5505 KW - Fluorine Radioisotopes KW - 0 KW - Radiopharmaceuticals KW - 6-fluorodopamine KW - 59043-70-8 KW - Desipramine KW - TG537D343B KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Sensitivity and Specificity KW - Reproducibility of Results KW - Heart Ventricles -- diagnostic imaging KW - Humans KW - Heart Ventricles -- drug effects KW - Heart Ventricles -- innervation KW - Adult KW - Aged KW - Middle Aged KW - Radionuclide Imaging KW - Dopamine -- analogs & derivatives KW - Autonomic Nervous System -- drug effects KW - Autonomic Nervous System -- diagnostic imaging KW - Sympathetic Nervous System -- drug effects KW - Shy-Drager Syndrome -- diagnostic imaging KW - Parkinsonian Disorders -- chemically induced KW - Shy-Drager Syndrome -- chemically induced KW - Parkinsonian Disorders -- diagnostic imaging KW - Autonomic Nervous System Diseases -- diagnostic imaging KW - Autonomic Nervous System Diseases -- chemically induced KW - Sympathetic Nervous System -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68765353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.atitle=Cardiac+and+extracardiac+sympathetic+denervation+in+Parkinson%27s+disease+with+orthostatic+hypotension+and+in+pure+autonomic+failure.&rft.au=Tipre%2C+Dnyanesh+N%3BGoldstein%2C+David+S&rft.aulast=Tipre&rft.aufirst=Dnyanesh&rft.date=2005-11-01&rft.volume=46&rft.issue=11&rft.spage=1775&rft.isbn=&rft.btitle=&rft.title=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-03 N1 - Date created - 2005-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells. AN - 68764596; 16227988 AB - CD4(+)CD25(+) regulatory T (T(reg)) cells have a crucial role in maintaining immune tolerance. Mice and humans born lacking T(reg) cells develop severe autoimmune disease, and depletion of T(reg) cells in lymphopenic mice induces autoimmunity. Interleukin (IL)-2 signaling is required for thymic development, peripheral expansion and suppressive activity of T(reg) cells. Animals lacking IL-2 die of autoimmunity, which is prevented by administration of IL-2-responsive T(reg) cells. In light of the emerging evidence that one of the primary physiologic roles of IL-2 is to generate and maintain T(reg) cells, the question arises as to the effects of IL-2 therapy on them. We monitored T(reg) cells during immune reconstitution in individuals with cancer who did or did not receive IL-2 therapy. CD4(+)CD25(hi) cells underwent homeostatic peripheral expansion during immune reconstitution, and in lymphopenic individuals receiving IL-2, the T(reg) cell compartment was markedly increased. Mouse studies showed that IL-2 therapy induced expansion of existent T(reg) cells in normal hosts, and IL-2-induced T(reg) cell expansion was further augmented by lymphopenia. On a per-cell basis, T(reg) cells generated by IL-2 therapy expressed similar levels of FOXP3 and had similar potency for suppression compared to T(reg) cells present in normal hosts. These studies suggest that IL-2 and lymphopenia are primary modulators of CD4(+)CD25(+) T(reg) cell homeostasis. JF - Nature medicine AU - Zhang, Hua AU - Chua, Kevin S AU - Guimond, Martin AU - Kapoor, Veena AU - Brown, Margaret V AU - Fleisher, Thomas A AU - Long, Lauren M AU - Bernstein, Donna AU - Hill, Brenna J AU - Douek, Daniel C AU - Berzofsky, Jay A AU - Carter, Charles S AU - Read, E J AU - Helman, Lee J AU - Mackall, Crystal L AD - Pediatric Oncology Branch, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA. Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 1238 EP - 1243 VL - 11 IS - 11 SN - 1078-8956, 1078-8956 KW - Forkhead Transcription Factors KW - 0 KW - Foxp3 protein, mouse KW - Interleukin-2 KW - Receptors, Interleukin-2 KW - Recombinant Proteins KW - Index Medicus KW - Animals KW - Homeostasis -- immunology KW - Humans KW - Child KW - Mice KW - Sarcoma -- drug therapy KW - Mice, Knockout KW - Lymphocyte Transfusion KW - Adult KW - Mice, Inbred C57BL KW - Sarcoma -- complications KW - Middle Aged KW - Adolescent KW - Recombinant Proteins -- therapeutic use KW - Female KW - Forkhead Transcription Factors -- analysis KW - Receptors, Interleukin-2 -- metabolism KW - Interleukin-2 -- administration & dosage KW - T-Lymphocytes, Regulatory -- drug effects KW - Lymphopenia -- chemically induced KW - Interleukin-2 -- therapeutic use KW - CD4-Positive T-Lymphocytes -- immunology KW - Lymphopenia -- immunology KW - Interleukin-2 -- immunology KW - CD4-Positive T-Lymphocytes -- drug effects KW - Lymphopenia -- drug therapy KW - Receptors, Interleukin-2 -- immunology KW - T-Lymphocytes, Regulatory -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68764596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+medicine&rft.atitle=Lymphopenia+and+interleukin-2+therapy+alter+homeostasis+of+CD4%2BCD25%2B+regulatory+T+cells.&rft.au=Zhang%2C+Hua%3BChua%2C+Kevin+S%3BGuimond%2C+Martin%3BKapoor%2C+Veena%3BBrown%2C+Margaret+V%3BFleisher%2C+Thomas+A%3BLong%2C+Lauren+M%3BBernstein%2C+Donna%3BHill%2C+Brenna+J%3BDouek%2C+Daniel+C%3BBerzofsky%2C+Jay+A%3BCarter%2C+Charles+S%3BRead%2C+E+J%3BHelman%2C+Lee+J%3BMackall%2C+Crystal+L&rft.aulast=Zhang&rft.aufirst=Hua&rft.date=2005-11-01&rft.volume=11&rft.issue=11&rft.spage=1238&rft.isbn=&rft.btitle=&rft.title=Nature+medicine&rft.issn=10788956&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-28 N1 - Date created - 2005-11-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Opposing effects of amygdala and orbital prefrontal cortex lesions on the extinction of instrumental responding in macaque monkeys. AN - 68756769; 16262672 AB - Extinction is a well-known behavioural phenomenon that allows organisms to respond flexibly to a changing environment. Although recent work implicates the amygdala and orbital prefrontal cortex (PFo) in extinction of Pavlovian conditioned fear and aversion, much less is known about the neural bases of instrumental extinction. To explore the contribution of the macaque amygdala to flexible responding in the face of changing reward contingency, we tested the effects of selective, excitotoxic lesions of the amygdala on extinction of an instrumental response. For comparison, we evaluated the effects of ablation of PFo on the same task. Amygdala lesions facilitated the extinction of instrumental responses, whereas lesions of PFo had the opposite effect. JF - The European journal of neuroscience AU - Izquierdo, Alicia AU - Murray, Elisabeth A AD - Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA. Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 2341 EP - 2346 VL - 22 IS - 9 SN - 0953-816X, 0953-816X KW - Excitatory Amino Acid Agonists KW - 0 KW - Ibotenic Acid KW - 2552-55-8 KW - Index Medicus KW - Animals KW - Suction -- methods KW - Reward KW - Macaca mulatta KW - Ibotenic Acid -- toxicity KW - Excitatory Amino Acid Agonists -- toxicity KW - Male KW - Behavior, Animal KW - Prefrontal Cortex -- injuries KW - Conditioning, Classical -- physiology KW - Prefrontal Cortex -- physiology KW - Amygdala -- physiology KW - Extinction, Psychological -- physiology KW - Amygdala -- injuries KW - Amygdala -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68756769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+European+journal+of+neuroscience&rft.atitle=Opposing+effects+of+amygdala+and+orbital+prefrontal+cortex+lesions+on+the+extinction+of+instrumental+responding+in+macaque+monkeys.&rft.au=Izquierdo%2C+Alicia%3BMurray%2C+Elisabeth+A&rft.aulast=Izquierdo&rft.aufirst=Alicia&rft.date=2005-11-01&rft.volume=22&rft.issue=9&rft.spage=2341&rft.isbn=&rft.btitle=&rft.title=The+European+journal+of+neuroscience&rft.issn=0953816X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-17 N1 - Date created - 2005-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The role of IL-6 and STAT3 in inflammation and cancer. AN - 68755428; 16199153 AB - The defense of the host from foreign pathogens is the commonly accepted function of the vertebrate immune system. A complex system consisting of many differing cells and structures communicating by both soluble and cell bound ligands, serves to protect the host from infection, and plays a role in preventing the development of certain types of tumours. Numerous signalling pathways are involved in the coordination of the immune system, serving both to activate and attenuate its responses to attack. The ability of the immune system, specifically those cells involved in acute inflammatory responses, to mediate the directed (and sometimes indirect) killing of cells and pathogens, make it a potential threat to host survival. Furthermore, the production and release of various survival factors such as the pleiotropic cytokine IL-6, a major mediator of inflammation and activator of signal transducer and activator of transcription 3, serves to block apoptosis in cells during the inflammatory process, keeping them alive in very toxic environments. Unfortunately, these same pathways serve also to maintain cells progressing towards neoplastic growth, protecting them from cellular apoptotic deletion and chemotherapeutic drugs. Here, we discuss the relationships between cancer and inflammation, and some of the molecular mechanisms involved in mediating the unintended consequences of host defense and tumour survival. JF - European journal of cancer (Oxford, England : 1990) AU - Hodge, David R AU - Hurt, Elaine M AU - Farrar, William L AD - Laboratory of Molecular Immunoregulation, Cytokine Molecular Mechanisms Section, Center for Cancer Research, The National Cancer Institute at Frederick, Frederick, MD 21702, USA. Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 2502 EP - 2512 VL - 41 IS - 16 SN - 0959-8049, 0959-8049 KW - Interleukin-6 KW - 0 KW - STAT Transcription Factors KW - STAT3 Transcription Factor KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Index Medicus KW - Humans KW - Signal Transduction -- genetics KW - Signal Transduction -- immunology KW - Drug Resistance, Neoplasm -- immunology KW - STAT Transcription Factors -- physiology KW - Immunotherapy -- methods KW - STAT3 Transcription Factor -- physiology KW - Interleukin-6 -- physiology KW - Inflammation -- genetics KW - Inflammation -- immunology KW - Neoplasms -- therapy KW - Protein-Tyrosine Kinases -- physiology KW - Neoplasms -- genetics KW - Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68755428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+cancer+%28Oxford%2C+England+%3A+1990%29&rft.atitle=The+role+of+IL-6+and+STAT3+in+inflammation+and+cancer.&rft.au=Hodge%2C+David+R%3BHurt%2C+Elaine+M%3BFarrar%2C+William+L&rft.aulast=Hodge&rft.aufirst=David&rft.date=2005-11-01&rft.volume=41&rft.issue=16&rft.spage=2502&rft.isbn=&rft.btitle=&rft.title=European+journal+of+cancer+%28Oxford%2C+England+%3A+1990%29&rft.issn=09598049&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-15 N1 - Date created - 2005-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Meeting report: Structural determination of environmentally responsive proteins. AN - 68751564; 16263521 AB - The three-dimensional structure of gene products continues to be a missing lynchpin between linear genome sequences and our understanding of the normal and abnormal function of proteins and pathways. Enhanced activity in this area is likely to lead to better understanding of how discrete changes in molecular patterns and conformation underlie functional changes in protein complexes and, with it, sensitivity of an individual to an exposure. The National Institute of Environmental Health Sciences convened a workshop of experts in structural determination and environmental health to solicit advice for future research in structural resolution relative to environmentally responsive proteins and pathways. The highest priorities recommended by the workshop were to support studies of structure, analysis, control, and design of conformational and functional states at molecular resolution for environmentally responsive molecules and complexes; promote understanding of dynamics, kinetics, and ligand responses; investigate the mechanisms and steps in posttranslational modifications, protein partnering, impact of genetic polymorphisms on structure/function, and ligand interactions; and encourage integrated experimental and computational approaches. The workshop participants also saw value in improving the throughput and purity of protein samples and macromolecular assemblies; developing optimal processes for design, production, and assembly of macromolecular complexes; encouraging studies on protein-protein and macromolecular interactions; and examining assemblies of individual proteins and their functions in pathways of interest for environmental health. JF - Environmental health perspectives AU - Reinlib, Leslie AD - Division of Extramural Research and Training, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina 27709-2233, USA. reinlib@niehs.nih.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 1622 EP - 1626 VL - 113 IS - 11 SN - 0091-6765, 0091-6765 KW - Ligands KW - 0 KW - Macromolecular Substances KW - Proteins KW - Index Medicus KW - Environmental Health KW - Protein Processing, Post-Translational KW - Toxicogenetics KW - Protein Binding KW - Proteins -- chemistry KW - Proteins -- metabolism KW - Protein Conformation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68751564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Meeting+report%3A+Structural+determination+of+environmentally+responsive+proteins.&rft.au=Reinlib%2C+Leslie&rft.aulast=Reinlib&rft.aufirst=Leslie&rft.date=2005-11-01&rft.volume=113&rft.issue=11&rft.spage=1622&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-26 N1 - Date created - 2005-11-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Struct Biol. 2001 Oct;8(10):822-4 [11573079] Bioinformatics. 2005 Jun 15;21(12):2814-20 [15827081] Annu Rev Genomics Hum Genet. 2002;3:243-62 [12194989] Nature. 2003 Jan 23;421(6921):431-5 [12540917] Curr Opin Struct Biol. 2003 Dec;13(6):748-57 [14675554] Nucleic Acids Res. 2004 Jan 1;32(Database issue):D217-22 [14681398] Biochemistry. 2004 Feb 24;43(7):1950-62 [14967035] Curr Med Chem. 2004 Mar;11(5):525-38 [15032601] Curr Top Med Chem. 2004;4(7):687-700 [15032682] Curr Med Chem. 2004 Apr;11(8):1065-84 [15078166] Mol Interv. 2004 Jun;4(3):147-56 [15210868] Nature. 2004 Oct 21;431(7011):931-45 [15496913] Genomics Proteomics Bioinformatics. 2004 Feb;2(1):1-5 [15629037] FEBS J. 2005 Jan;272(2):293-312 [15654870] Curr Opin Struct Biol. 2005 Feb;15(1):15-22 [15718128] Bioinformatics. 2005 May 1;21(9):1901-7 [15657096] Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14274-9 [11724958] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Recovery of erection after pelvic urologic surgery: our experience. AN - 68744912; 15889123 AB - The incidence of erectile dysfunction (ED) in patients undergoing pelvic urologic surgery, the efficacy and tolerability of vardenafil-based rehabilitative treatment as first option in these patients, the role of spontaneous erection (SE) as a possible positive predictive factor to erection recovery after such treatment, and the role of second-line therapies in those nonresponders are evaluated. All the patients undergoing pelvic urologic surgery at our Institution between November 2002 and December 2003 were considered. Preoperative erectile function (EF) was evaluated by using the abridged five-item version of the International Index of Erectile Function (IIEF5) questionnaire. Study population was divided into separate groups considering grade of preoperative EF, nerve sparing (NS) surgery and type of procedure (radical prostatectomy, radical cystectomy (RC) or nerve and seminal sparing cystectomy). In total, 86 patients were evaluated. After 6 months, an increase in mean IIEF5 score of 12.9 points was found in those who had undergone a bilateral NSRP after vardenafil therapy, of 8.0 points in those who had undergone unilateral NSRP, of 11.3 in those who had undergone NSRC and of 11.5 in nerve and seminal sparing cistectomies. A better vardenafil response was found in patients with SE+(P<0.001). Among those vardenafil notresponders, 13 were treated by using intracavernous injections, one by vacuum device and three with penile prosthesis implant. In conclusion, in our experience, vardenafil showed to be well tolerated and effective for recovery of EF in patients undergoing pelvic urologic surgery. This drug was particularly effective for those with a normal preoperative EF undergoing an NS procedure. Of course, it should be recognized that the absence of a control group in the study represents an important limitation. However, based on the data from the literature, there is a strong belief that such an approach will lead to an earlier recovery of EF than without rehabilitative treatment. JF - International journal of impotence research AU - Gallo, L AU - Perdonã, S AU - Autorino, R AU - Celentano, E AU - Menna, L AU - Di Lorenzo, G AU - Gallo, A AD - Division of Urology, National Cancer Institute, Fondazione Pascale, Naples, Italy. gigginogallo@tin.it PY - 2005 SP - 484 EP - 493 VL - 17 IS - 6 SN - 0955-9930, 0955-9930 KW - Imidazoles KW - 0 KW - Phosphodiesterase Inhibitors KW - Piperazines KW - Sulfones KW - Triazines KW - Vardenafil Dihydrochloride KW - 5O8R96XMH7 KW - Index Medicus KW - Cystectomy -- adverse effects KW - Humans KW - Piperazines -- therapeutic use KW - Urinary Bladder Neoplasms -- surgery KW - Aged KW - Piperazines -- adverse effects KW - Phosphodiesterase Inhibitors -- therapeutic use KW - Phosphodiesterase Inhibitors -- adverse effects KW - Cystectomy -- methods KW - Sulfones -- adverse effects KW - Prostatectomy -- methods KW - Prostatectomy -- adverse effects KW - Sulfones -- therapeutic use KW - Prostatic Neoplasms -- surgery KW - Surveys and Questionnaires KW - Imidazoles -- therapeutic use KW - Middle Aged KW - Triazines -- adverse effects KW - Triazines -- therapeutic use KW - Imidazoles -- adverse effects KW - Male KW - Urologic Surgical Procedures, Male -- adverse effects KW - Erectile Dysfunction -- drug therapy KW - Erectile Dysfunction -- etiology KW - Erectile Dysfunction -- epidemiology KW - Penile Erection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68744912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+impotence+research&rft.atitle=Recovery+of+erection+after+pelvic+urologic+surgery%3A+our+experience.&rft.au=Gallo%2C+L%3BPerdon%C3%A3%2C+S%3BAutorino%2C+R%3BCelentano%2C+E%3BMenna%2C+L%3BDi+Lorenzo%2C+G%3BGallo%2C+A&rft.aulast=Gallo&rft.aufirst=L&rft.date=2005-11-01&rft.volume=17&rft.issue=6&rft.spage=484&rft.isbn=&rft.btitle=&rft.title=International+journal+of+impotence+research&rft.issn=09559930&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-31 N1 - Date created - 2005-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Redundant roles for nucleocapsid and matrix RNA-binding sequences in human immunodeficiency virus type 1 assembly. AN - 68740344; 16254319 AB - RNA appears to be required for the assembly of retroviruses. This is likely due to binding of RNA by multiple Gags, which in turn organizes and stabilizes the Gag-Gag interactions that form the virion. While the nucleocapsid (NC) domain is the most conspicuous RNA-binding region of the human immunodeficiency virus type 1 (HIV-1) Gag polyprotein, we have previously shown that NC is not strictly required for efficient particle production. To determine if an RNA requirement for HIV-1 assembly exists, we analyzed virions produced by an NC deletion mutant for the presence of RNA. The results revealed that virions without NC still contained significant amounts of RNA. Since these packaged RNAs are probably incorporated by other RNA-binding sequences in Gag, an RNA-binding site in the matrix protein (MA) of Gag was mutated. While this mutation did not interfere with HIV-1 replication, a construct with both MA and NC mutations (MX/NX) failed to produce particles. The MX/NX mutant was rescued in trans by coassembly with several forms of Gag: wild-type Gag, either of the single-mutant Gags, or Gag truncations that contain MA or NC sequences. Addition of basic sequences to the MX/NX mutant partially restored particle production, consistent with a requirement for Gag-RNA binding in addition to Gag-Gag interactions. Together, these results support an RNA-binding requirement for Gag assembly, which relies on binding of RNA by MA or NC sequences to condense, organize, and stabilize the HIV-1 Gag-Gag interactions that form the virion. JF - Journal of virology AU - Ott, David E AU - Coren, Lori V AU - Gagliardi, Tracy D AD - Basic Research Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702-1201, USA. ott@ncifcrf.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 13839 EP - 13847 VL - 79 IS - 22 SN - 0022-538X, 0022-538X KW - Gene Products, gag KW - 0 KW - RNA, Viral KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Gene Products, gag -- genetics KW - Virion -- genetics KW - Transfection KW - Proviruses -- genetics KW - Molecular Sequence Data KW - Genetic Complementation Test KW - Amino Acid Sequence KW - Cloning, Molecular KW - HIV-1 -- genetics KW - Nucleocapsid -- genetics KW - RNA, Viral -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68740344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Redundant+roles+for+nucleocapsid+and+matrix+RNA-binding+sequences+in+human+immunodeficiency+virus+type+1+assembly.&rft.au=Ott%2C+David+E%3BCoren%2C+Lori+V%3BGagliardi%2C+Tracy+D&rft.aulast=Ott&rft.aufirst=David&rft.date=2005-11-01&rft.volume=79&rft.issue=22&rft.spage=13839&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-27 N1 - Date created - 2005-10-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 1993 Nov 26;262(5138):1401-7 [8248779] Proc Natl Acad Sci U S A. 1991 May 15;88(10):4528-32 [2034693] Virology. 2000 Jan 5;266(1):42-51 [10612659] J Virol. 2000 Apr;74(7):3046-57 [10708419] J Virol. 2000 Jun;74(12):5395-402 [10823843] J Virol. 2000 Aug;74(15):6734-40 [10888611] J Virol. 2000 Aug;74(16):7238-49 [10906178] Virology. 2000 Dec 5;278(1):111-21 [11112487] Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5246-51 [11320254] RNA. 2001 Apr;7(4):576-84 [11345436] Virology. 2002 Feb 15;293(2):368-78 [11886257] J Virol. 2002 Apr;76(8):4131-7 [11907255] J Virol. 2002 Jun;76(11):5452-62 [11991973] J Virol. 2002 Nov;76(22):11177-85 [12388677] J Virol. 2002 Nov;76(22):11405-13 [12388701] J Virol. 2003 May;77(10):5547-56 [12719547] J Virol. 2004 Jan;78(1):52-60 [14671087] J Virol. 2004 Jan;78(2):716-23 [14694103] J Virol. 2004 Aug;78(16):8486-95 [15280457] J Biol Chem. 2004 Aug 20;279(34):35822-8 [15210704] J Virol. 2004 Nov;78(22):12378-85 [15507624] J Mol Biol. 1970 Sep 14;52(2):387-90 [4320940] Virology. 1973 Apr;52(2):456-67 [4705382] J Virol. 1979 Jan;29(1):328-35 [219227] Nature. 1981 Oct 15-21;293(5833):543-8 [6169994] J Gen Virol. 1992 Dec;73 ( Pt 12):3079-86 [1469349] J Virol. 1993 Nov;67(11):6487-98 [8411352] J Virol. 1987 Jan;61(1):209-13 [3640832] Proc Natl Acad Sci U S A. 1988 Nov;85(22):8420-4 [3141927] J Virol. 1989 Apr;63(4):1558-68 [2926863] J Virol. 1990 Jul;64(7):3207-11 [2191147] Biotechniques. 1990 May;8(5):528-35 [2357375] Curr Top Microbiol Immunol. 1990;157:125-52 [2394131] J Virol. 1991 Jan;65(1):71-80 [1985218] Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3213-7 [2014242] Virology. 1995 Feb 1;206(2):854-65 [7856098] J Virol. 1995 Oct;69(10):6487-97 [7666550] J Virol. 1996 Aug;70(8):5106-14 [8764018] Curr Top Microbiol Immunol. 1996;214:177-218 [8791728] J Virol. 1996 Oct;70(10):6607-16 [8794295] J Virol. 1996 Oct;70(10):6820-5 [8794322] Virology. 1996 Dec 15;226(2):294-305 [8955049] J Virol. 1997 Feb;71(2):1443-52 [8995670] Virology. 1997 Mar 31;230(1):125-33 [9126268] Virology. 1997 Mar 31;230(1):134-44 [9126269] J Virol. 1997 Jun;71(6):4425-35 [9151833] Nucleic Acids Res. 1997 Jul 15;25(14):2902-10 [9207041] Eur J Biochem. 1997 Oct 15;249(2):592-600 [9370371] J Virol. 1998 Mar;72(3):1782-9 [9499028] J Virol. 1998 Mar;72(3):1902-9 [9499042] Trends Biochem Sci. 1998 Aug;23(8):297-301 [9757830] Virology. 1998 Nov 10;251(1):1-15 [9813197] J Mol Biol. 1999 Jan 8;285(1):1-32 [9878383] Science. 1999 Jan 1;283(5398):80-3 [9872746] J Virol. 1999 Mar;73(3):2270-9 [9971810] J Virol. 1999 Jul;73(7):5388-401 [10364286] J Virol. 1999 Oct;73(10):8527-40 [10482606] Mol Cell. 2005 Jan 7;17(1):137-43 [15629724] J Virol. 2005 Apr;79(7):4055-65 [15767407] J Virol. 2005 Jul;79(14):9038-45 [15994797] J Virol. 1994 Oct;68(10):6782-6 [8084015] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function. AN - 68737641; 16222229 AB - Mitochondrial dysfunction has emerged as a common theme that underlies numerous neurological disorders, including Down syndrome. Down syndrome cultures and tissues show mitochondrial damage such as impaired mitochondrial enzyme activities, defective mitochondrial DNA repairs and accumulation of toxic free radicals, but the cause of mitochondrial dysfunction remains elusive. Here we demonstrate that the Drosophila melanogaster homolog of human Down syndrome critical region gene 1 (DSCR1), nebula (also known as sarah, sra), has a crucial role in the maintenance of mitochondrial function and integrity. We report that nebula protein is located in the mitochondria. An alteration in the abundance of nebula affects mitochondrial enzyme activities, mitochondrial DNA content, and the number and size of mitochondria. Furthermore, nebula interacts with the ADP/ATP translocator and influences its activity. These results identify nebula/DSCR1 as a regulator of mitochondrial function and integrity and further suggest that an increased level of DSCR1 may contribute to the mitochondrial dysfunction seen in Down syndrome. JF - Nature neuroscience AU - Chang, Karen T AU - Min, Kyung-Tai AD - Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 1577 EP - 1585 VL - 8 IS - 11 SN - 1097-6256, 1097-6256 KW - DNA, Mitochondrial KW - 0 KW - DSC1 protein, human KW - Desmocollins KW - Drosophila Proteins KW - Membrane Glycoproteins KW - Reactive Oxygen Species KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Mitochondrial ADP, ATP Translocases KW - 9068-80-8 KW - Prostaglandin-Endoperoxide Synthases KW - EC 1.14.99.1 KW - Succinate Dehydrogenase KW - EC 1.3.99.1 KW - Calcineurin KW - EC 3.1.3.16 KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Age Factors KW - Calcineurin -- metabolism KW - Drosophila melanogaster -- chemistry KW - Larva KW - Humans KW - Blotting, Western -- methods KW - Brain -- metabolism KW - Immunohistochemistry -- methods KW - Animals, Genetically Modified KW - Neuropil -- metabolism KW - Neuropil -- ultrastructure KW - Mitochondrial ADP, ATP Translocases -- metabolism KW - Microscopy, Electron, Transmission -- methods KW - Prostaglandin-Endoperoxide Synthases -- metabolism KW - Photoreceptor Cells, Invertebrate -- ultrastructure KW - Microscopy, Immunoelectron -- methods KW - Adenosine Triphosphate -- metabolism KW - DNA, Mitochondrial -- metabolism KW - Immunoprecipitation -- methods KW - Subcellular Fractions -- metabolism KW - Succinate Dehydrogenase -- metabolism KW - Mutation KW - Mitochondria -- physiology KW - Drosophila Proteins -- chemistry KW - Mitochondria -- ultrastructure KW - Membrane Glycoproteins -- physiology KW - Drosophila Proteins -- genetics KW - Membrane Glycoproteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68737641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+neuroscience&rft.atitle=Drosophila+melanogaster+homolog+of+Down+syndrome+critical+region+1+is+critical+for+mitochondrial+function.&rft.au=Chang%2C+Karen+T%3BMin%2C+Kyung-Tai&rft.aulast=Chang&rft.aufirst=Karen&rft.date=2005-11-01&rft.volume=8&rft.issue=11&rft.spage=1577&rft.isbn=&rft.btitle=&rft.title=Nature+neuroscience&rft.issn=10976256&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-25 N1 - Date created - 2005-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The role of neuroadaptations in relapse to drug seeking. AN - 68737607; 16251983 AB - One of the most difficult problems in treating addiction is not withdrawing addicts from drugs, but preventing relapse. Persistent neuroadaptations are thought to underlie aspects of addiction, including relapse. This commentary assesses the degree to which these neuroadaptations, primarily identified in preclinical studies on cocaine, induce relapse. JF - Nature neuroscience AU - Shaham, Yavin AU - Hope, Bruce T AD - Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA. yshaham@intra.nida.nih.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 1437 EP - 1439 VL - 8 IS - 11 SN - 1097-6256, 1097-6256 KW - Index Medicus KW - Animals KW - Amygdala -- physiopathology KW - Humans KW - Time Factors KW - Recurrence KW - Cocaine-Related Disorders -- psychology KW - Cocaine-Related Disorders -- physiopathology KW - Adaptation, Physiological KW - Cocaine-Related Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68737607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+neuroscience&rft.atitle=The+role+of+neuroadaptations+in+relapse+to+drug+seeking.&rft.au=Shaham%2C+Yavin%3BHope%2C+Bruce+T&rft.aulast=Shaham&rft.aufirst=Yavin&rft.date=2005-11-01&rft.volume=8&rft.issue=11&rft.spage=1437&rft.isbn=&rft.btitle=&rft.title=Nature+neuroscience&rft.issn=10976256&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-25 N1 - Date created - 2005-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Laboratory models of alcoholism: treatment target identification and insight into mechanisms. AN - 68737436; 16251990 AB - Laboratory models, including animal tissues and live animals, have proven useful for discovery of molecular targets of alcohol action as well as for characterization of genetic and environmental factors that influence alcohol's neural actions. Here we consider strengths and weaknesses of laboratory models used in alcohol research and analyze the limitations of using animals to model a complex human disease. We describe targets for the neural actions of alcohol, and we review studies in which animal models were used to examine excessive alcohol drinking and to discover genes that may contribute to risk for alcoholism. Despite some limitations of the laboratory models used in alcohol research, these experimental approaches are likely to contribute to the development of new therapies for alcohol abuse and alcoholism. JF - Nature neuroscience AU - Lovinger, David M AU - Crabbe, John C AD - Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland 20852, USA. lovindav@mail.nih.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 1471 EP - 1480 VL - 8 IS - 11 SN - 1097-6256, 1097-6256 KW - Index Medicus KW - Environment KW - Animals KW - Models, Genetic KW - Humans KW - Genetic Predisposition to Disease KW - Models, Biological KW - Alcoholism -- therapy KW - Disease Models, Animal KW - Alcoholism -- metabolism KW - Alcoholism -- physiopathology KW - Alcoholism -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68737436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+neuroscience&rft.atitle=Laboratory+models+of+alcoholism%3A+treatment+target+identification+and+insight+into+mechanisms.&rft.au=Lovinger%2C+David+M%3BCrabbe%2C+John+C&rft.aulast=Lovinger&rft.aufirst=David&rft.date=2005-11-01&rft.volume=8&rft.issue=11&rft.spage=1471&rft.isbn=&rft.btitle=&rft.title=Nature+neuroscience&rft.issn=10976256&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-25 N1 - Date created - 2005-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The neuroscience of addiction. AN - 68735315; 16251981 JF - Nature neuroscience AU - Volkow, Nora AU - Li, Ting-Kai AD - National Institute on Drug Abuse, USA. Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 1429 EP - 1430 VL - 8 IS - 11 SN - 1097-6256, 1097-6256 KW - Index Medicus KW - Humans KW - Neurobiology KW - Substance-Related Disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68735315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+neuroscience&rft.atitle=The+neuroscience+of+addiction.&rft.au=Volkow%2C+Nora%3BLi%2C+Ting-Kai&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2005-11-01&rft.volume=8&rft.issue=11&rft.spage=1429&rft.isbn=&rft.btitle=&rft.title=Nature+neuroscience&rft.issn=10976256&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-25 N1 - Date created - 2005-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bacillus anthracis edema toxin causes extensive tissue lesions and rapid lethality in mice. AN - 68733801; 16251415 AB - Bacillus anthracis edema toxin (ET), an adenylyl cyclase, is an important virulence factor that contributes to anthrax disease. The role of ET in anthrax pathogenesis is, however, poorly understood. Previous studies using crude toxin preparations associated ET with subcutaneous edema, and ET-deficient strains of B. anthracis showed a reduction in virulence. We report the first comprehensive study of ET-induced pathology in an animal model. Highly purified ET caused death in BALB/cJ mice at lower doses and more rapidly than previously seen with the other major B. anthracis virulence factor, lethal toxin. Observations of gross pathology showed intestinal intralumenal fluid accumulation followed by focal hemorrhaging of the ileum and adrenal glands. Histopathological analyses of timed tissue harvests revealed lesions in several tissues including adrenal glands, lymphoid organs, bone, bone marrow, gastrointestinal mucosa, heart, and kidneys. Concomitant blood chemistry analyses supported the induction of tissue damage. Several cytokines increased after ET administration, including granulocyte colony-stimulating factor, eotaxin, keratinocyte-derived cytokine, MCP-1/JE, interleukin-6, interleukin-10, and interleukin-1beta. Physiological measurements also revealed a concurrent hypotension and bradycardia. These studies detail the extensive pathological lesions caused by ET and suggest that it causes death due to multiorgan failure. JF - The American journal of pathology AU - Firoved, Aaron M AU - Miller, Georgina F AU - Moayeri, Mahtab AU - Kakkar, Rahul AU - Shen, Yuequan AU - Wiggins, Jason F AU - McNally, Elizabeth M AU - Tang, Wei-Jen AU - Leppla, Stephen H AD - National Institute of Allergy and Infectious Diseases, Office of Research Services, National Institutes of Health, 30 Convent Dr., Building 30, Room 303, Bethesda, MD 20892-4349, USA. Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 1309 EP - 1320 VL - 167 IS - 5 SN - 0002-9440, 0002-9440 KW - Antigens, Bacterial KW - 0 KW - Bacterial Toxins KW - Cytokines KW - Virulence Factors KW - anthrax toxin KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Bone Marrow -- pathology KW - Kidney -- pathology KW - Lymphoid Tissue -- pathology KW - Myocardium -- pathology KW - Virulence Factors -- toxicity KW - Cytokines -- biosynthesis KW - Mice KW - Ileum -- pathology KW - Mice, Inbred BALB C KW - Hemorrhage KW - Adrenal Glands -- pathology KW - Gastric Mucosa -- pathology KW - Bone and Bones -- pathology KW - Multiple Organ Failure KW - Adenylyl Cyclases -- toxicity KW - Intestinal Mucosa -- pathology KW - Antigens, Bacterial -- toxicity KW - Bacillus anthracis -- pathogenicity KW - Bacterial Toxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68733801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+pathology&rft.atitle=Bacillus+anthracis+edema+toxin+causes+extensive+tissue+lesions+and+rapid+lethality+in+mice.&rft.au=Firoved%2C+Aaron+M%3BMiller%2C+Georgina+F%3BMoayeri%2C+Mahtab%3BKakkar%2C+Rahul%3BShen%2C+Yuequan%3BWiggins%2C+Jason+F%3BMcNally%2C+Elizabeth+M%3BTang%2C+Wei-Jen%3BLeppla%2C+Stephen+H&rft.aulast=Firoved&rft.aufirst=Aaron&rft.date=2005-11-01&rft.volume=167&rft.issue=5&rft.spage=1309&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+pathology&rft.issn=00029440&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-26 N1 - Date created - 2005-10-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Chest. 1999 Nov;116(5):1369-76 [10559102] Rev Physiol Biochem Pharmacol. 2004;152:135-64 [15549606] Hypertension. 2000 Nov;36(5):912-6 [11082166] Biochem J. 2000 Dec 15;352 Pt 3:739-45 [11104681] J Leukoc Biol. 2001 Apr;69(4):513-21 [11310836] Mod Pathol. 2001 May;14(5):482-95 [11353060] AJR Am J Roentgenol. 2001 Aug;177(2):357-8 [11461861] Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1122-7 [11701424] Emerg Infect Dis. 2001 Nov-Dec;7(6):933-44 [11747719] Nature. 2002 Jan 24;415(6870):396-402 [11807546] JAMA. 2002 Feb 20;287(7):863-8 [11851578] Annu Rev Immunol. 2002;20:125-63 [11861600] Int J Mol Med. 2002 Jul;10(1):3-10 [12060844] J Clin Invest. 2002 Jul;110(2):203-8 [12122112] Curr Top Microbiol Immunol. 2002;271:1-19 [12224519] FEBS Lett. 2002 Nov 20;531(3):384-8 [12435580] Clin Infect Dis. 2003 Feb 1;36(3):328-36 [12539075] J Allergy Clin Immunol. 2003 Feb;111(2 Suppl):S460-75 [12592293] J Endocrinol. 2003 Jun;177(3):357-64 [12773115] J Biol Chem. 2003 Jul 11;278(28):25990-7 [12676933] J Pathol. 2003 Jul;200(4):516-25 [12845619] Am J Pathol. 2003 Aug;163(2):701-9 [12875989] Eur J Immunol. 2003 Aug;33(8):2287-96 [12884304] Lab Invest. 2003 Aug;83(8):1201-9 [12920249] J Clin Invest. 2003 Sep;112(5):670-82 [12952916] AJR Am J Roentgenol. 2003 Oct;181(4):1071-8 [14500233] Annu Rev Cell Dev Biol. 2003;19:45-70 [14570563] Lancet. 2004 Jan 17;363(9404):223-33 [14738797] Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3242-7 [14978283] Clin Sci (Lond). 2004 Aug;107(2):111-23 [15113280] Infect Immun. 2004 Aug;72(8):4439-47 [15271901] Infect Immun. 2004 Aug;72(8):4801-9 [15271942] Cardiovasc Res. 2004 Aug 15;63(3):414-22 [15276466] J Pharmacol Exp Ther. 1977 Jun;201(3):678-88 [194027] Proc Natl Acad Sci U S A. 1982 May;79(10):3162-6 [6285339] Biochem Biophys Res Commun. 1987 Jan 30;142(2):454-60 [3493003] J Biol Chem. 1991 May 5;266(13):8595-603 [2022671] Infect Immun. 1991 Oct;59(10):3472-7 [1910002] Microb Pathog. 1991 Mar;10(3):183-98 [1654495] Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2291-4 [8460135] Infect Immun. 1994 Oct;62(10):4432-9 [7927706] Lab Invest. 1995 Nov;73(5):691-702 [7474943] Exp Anim. 1995 Oct;44(4):285-91 [8575542] Mol Med. 1998 Feb;4(2):87-95 [9508786] Science. 1998 May 1;280(5364):734-7 [9563949] Mol Microbiol. 1998 Jul;29(2):581-91 [9720874] Psychoneuroendocrinology. 1998 Jul;23(5):505-17 [9802125] Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13899-904 [9811898] Clin Sci (Lond). 1999 May;96(5):513-23 [10209084] Trends Microbiol. 1999 Apr;7(4):172-6 [10217833] J Gen Microbiol. 1961 Sep;26:49-63 [13916257] Infect Immun. 2000 Apr;68(4):1781-6 [10722564] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pharmacokinetics, safety, and tolerability of caspofungin in children and adolescents. AN - 68733470; 16251293 AB - Caspofungin is a parenteral antifungal that inhibits beta-1,3-D-glucan synthesis. Although licensed for adult use, the appropriate caspofungin dosing regimen in pediatric patients is not yet known. We therefore investigated the pharmacokinetics and safety of caspofungin in pediatric patients. Thirty-nine children (ages 2 to 11 years) and adolescents (ages 12 to 17 years) with neutropenia were administered caspofungin using either a weight-based regimen (1 mg/kg of body weight/day) or a body surface area regimen (50 mg/m2/day or 70 mg/m2/day). Plasma samples for caspofungin profiles were collected on days 1 and 4. These results were compared to those from adults treated with either 50 or 70 mg/day for mucosal candidiasis. In children receiving 1 mg/kg/day (maximum, 50 mg/day), the area under the concentration-time curve over 24 h (AUC(0-24)) was significantly smaller (46% after multiple doses) than that observed in adults receiving 50 mg/day (P < 0.001). In children and adolescents receiving 50 mg/m2/day (maximum, 70 mg/day), the AUC(0-24) following multiple doses was similar to that for the exposure in adults receiving 50 mg/day. The AUC(0-24) and concentration trough (at 24 h) in pediatric patients receiving the 50-mg/m2 daily regimen were consistent across the range of ages. Caspofungin was generally well tolerated in this study. None of the patients developed a serious drug-related adverse event or were discontinued for toxicity. These results demonstrate that caspofungin at 1 mg/kg/day in pediatric patients is suboptimal. Caspofungin administration at 50 mg/m2/day provides a comparable exposure to that of adult patients treated with 50 mg/day. JF - Antimicrobial agents and chemotherapy AU - Walsh, Thomas J AU - Adamson, Peter C AU - Seibel, Nita L AU - Flynn, Patricia M AU - Neely, Michael N AU - Schwartz, Cindy AU - Shad, Aziza AU - Kaplan, Sheldon L AU - Roden, Maureen M AU - Stone, Julie A AU - Miller, Alisha AU - Bradshaw, Susan K AU - Li, Susan X AU - Sable, Carole A AU - Kartsonis, Nicholas A AD - Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bldg. 10-CRC, Room 1W-5750, 10 Center Drive, Bethesda, Maryland 20892, USA. walsht@mail.nih.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 4536 EP - 4545 VL - 49 IS - 11 SN - 0066-4804, 0066-4804 KW - Antifungal Agents KW - 0 KW - Echinocandins KW - Lipopeptides KW - Peptides, Cyclic KW - caspofungin KW - F0XDI6ZL63 KW - Index Medicus KW - Humans KW - Body Surface Area KW - Adult KW - Child KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Peptides, Cyclic -- administration & dosage KW - Antifungal Agents -- pharmacokinetics KW - Peptides, Cyclic -- adverse effects KW - Peptides, Cyclic -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68733470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Pharmacokinetics%2C+safety%2C+and+tolerability+of+caspofungin+in+children+and+adolescents.&rft.au=Walsh%2C+Thomas+J%3BAdamson%2C+Peter+C%3BSeibel%2C+Nita+L%3BFlynn%2C+Patricia+M%3BNeely%2C+Michael+N%3BSchwartz%2C+Cindy%3BShad%2C+Aziza%3BKaplan%2C+Sheldon+L%3BRoden%2C+Maureen+M%3BStone%2C+Julie+A%3BMiller%2C+Alisha%3BBradshaw%2C+Susan+K%3BLi%2C+Susan+X%3BSable%2C+Carole+A%3BKartsonis%2C+Nicholas+A&rft.aulast=Walsh&rft.aufirst=Thomas&rft.date=2005-11-01&rft.volume=49&rft.issue=11&rft.spage=4536&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-18 N1 - Date created - 2005-10-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Antimicrob Agents Chemother. 1996 May;40(5):1277-9 [8723483] Leuk Lymphoma. 1993 Jul;10(4-5):369-76 [8220136] J Med Vet Mycol. 1997 Jul-Aug;35(4):285-7 [9292427] Antimicrob Agents Chemother. 1997 Nov;41(11):2326-32 [9371328] Antimicrob Agents Chemother. 1997 Nov;41(11):2333-8 [9371329] Bone Marrow Transplant. 1998 Apr;21 Suppl 2:S78-80 [9630334] Pediatr Infect Dis J. 1998 Nov;17(11):1007-11 [9849983] Eur J Clin Microbiol Infect Dis. 1999 Apr;18(4):302-4 [10385023] Clin Infect Dis. 2004 Dec 1;39(11):1563-71 [15578352] Bone Marrow Transplant. 1996 Dec;18 Suppl 3:S15-20 [8971401] Clin Infect Dis. 2001 Nov 1;33(9):1529-35 [11588698] Clin Infect Dis. 2002 Jan 1;34(1):7-14 [11731939] Antimicrob Agents Chemother. 2002 Jan;46(1):12-23 [11751105] Antimicrob Agents Chemother. 2002 Feb;46(2):451-7 [11796357] J Antimicrob Chemother. 2002 Feb;49 Suppl 1:69-73 [11801585] Antimicrob Agents Chemother. 2002 Mar;46(3):739-45 [11850256] Transpl Infect Dis. 2002 Mar;4(1):25-30 [12123423] Am J Med. 2002 Sep;113(4):294-9 [12361815] J Acquir Immune Defic Syndr. 2002 Oct 1;31(2):183-7 [12394797] Eur J Clin Microbiol Infect Dis. 2002 Nov;21(11):767-74 [12461585] N Engl J Med. 2002 Dec 19;347(25):2020-9 [12490683] Antimicrob Agents Chemother. 2003 Apr;47(4):1187-92 [12654645] Pediatr Infect Dis J. 2003 Aug;22(8):747-9 [12938676] Pediatrics. 2003 Sep;112(3 Pt 1):634-40 [12949295] Antimicrob Agents Chemother. 2004 Mar;48(3):815-23 [14982770] J Infect Dis. 2004 Oct 15;190(8):1464-71 [15378439] N Engl J Med. 2004 Sep 30;351(14):1391-402 [15459300] N Engl J Med. 1987 Oct 22;317(17):1098 [3657876] J Clin Oncol. 1990 Feb;8(2):280-6 [2299371] Clin Infect Dis. 1992 Feb;14(2):485-91 [1554835] Adv Pediatr Infect Dis. 1996;11:187-290 [8718464] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dynamic structure of the SPANX gene cluster mapped to the prostate cancer susceptibility locus HPCX at Xq27. AN - 68732380; 16251457 AB - Genetic linkage studies indicate that germline variations in a gene or genes on chromosome Xq27-28 are implicated in prostate carcinogenesis. The linkage peak of prostate cancer overlies a region of approximately 750 kb containing five SPANX genes (SPANX-A1, -A2, -B, -C, and -D) encoding sperm proteins associated with the nucleus; their expression was also detected in a variety of cancers. SPANX genes are >95% identical and reside within large segmental duplications (SDs) with a high level of similarity, which confounds mutational analysis of this gene family by routine PCR methods. In this work, we applied transformation-associated recombination cloning (TAR) in yeast to characterize individual SPANX genes from prostate cancer patients showing linkage to Xq27-28 and unaffected controls. Analysis of genomic TAR clones revealed a dynamic nature of the replicated region of linkage. Both frequent gene deletion/duplication and homology-based sequence transfer events were identified within the region and were presumably caused by recombinational interactions between SDs harboring the SPANX genes. These interactions contribute to diversity of the SPANX coding regions in humans. We speculate that the predisposition to prostate cancer in X-linked families is an example of a genomic disease caused by a specific architecture of the SPANX gene cluster. JF - Genome research AU - Kouprina, Natalay AU - Pavlicek, Adam AU - Noskov, Vladimir N AU - Solomon, Greg AU - Otstot, John AU - Isaacs, William AU - Carpten, John D AU - Trent, Jeffrey M AU - Schleutker, Joanna AU - Barrett, J Carl AU - Jurka, Jerzy AU - Larionov, Vladimir AD - Laboratory of Biosystems and Cancer, National Cancer Institute, Bethesda, Maryland 20892, USA. Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 1477 EP - 1486 VL - 15 IS - 11 SN - 1088-9051, 1088-9051 KW - Nuclear Proteins KW - 0 KW - SPANXA1 protein, human KW - SPANXA2 protein, human KW - SPANXD protein, human KW - Index Medicus KW - Yeasts KW - Base Sequence KW - Gene Components KW - Genomics -- methods KW - Recombination, Genetic -- genetics KW - Humans KW - Molecular Sequence Data KW - Sequence Analysis, DNA KW - Male KW - Cloning, Molecular KW - Gene Duplication KW - Nuclear Proteins -- genetics KW - Genetic Linkage -- genetics KW - Chromosomes, Human, X -- genetics KW - Prostatic Neoplasms -- genetics KW - Genetic Predisposition to Disease KW - Chromosome Mapping UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68732380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genome+research&rft.atitle=Dynamic+structure+of+the+SPANX+gene+cluster+mapped+to+the+prostate+cancer+susceptibility+locus+HPCX+at+Xq27.&rft.au=Kouprina%2C+Natalay%3BPavlicek%2C+Adam%3BNoskov%2C+Vladimir+N%3BSolomon%2C+Greg%3BOtstot%2C+John%3BIsaacs%2C+William%3BCarpten%2C+John+D%3BTrent%2C+Jeffrey+M%3BSchleutker%2C+Joanna%3BBarrett%2C+J+Carl%3BJurka%2C+Jerzy%3BLarionov%2C+Vladimir&rft.aulast=Kouprina&rft.aufirst=Natalay&rft.date=2005-11-01&rft.volume=15&rft.issue=11&rft.spage=1477&rft.isbn=&rft.btitle=&rft.title=Genome+research&rft.issn=10889051&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-02 N1 - Date created - 2005-10-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Gene. 2003 May 8;309(2):125-33 [12758128] Genome Res. 2003 May;13(5):781-93 [12727898] Nature. 2003 Jun 19;423(6942):825-37 [12815422] J Theor Biol. 2003 Sep 7;224(1):27-42 [12900202] Mod Pathol. 2004 Mar;17(3):380-8 [14752525] Int J Androl. 2004 Jun;27(3):134-9 [15139967] Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W48-9 [15215348] Virchows Arch. 2004 Jun;444(6):503-8 [15045584] Science. 2004 Jul 23;305(5683):525-8 [15273396] J Natl Cancer Inst. 2004 Aug 18;96(16):1240-7 [15316059] Genome Res. 2004 Oct;14(10A):1861-9 [15466286] Mol Biol Evol. 1989 Sep;6(5):526-38 [2677599] J Mol Biol. 1990 Oct 5;215(3):403-10 [2231712] Comput Chem. 1996 Mar;20(1):119-21 [8867843] Prostate. 2003 Dec 1;57(4):320-5 [14601028] Eur J Epidemiol. 2003;18(11):1027-36 [14620936] FEMS Microbiol Rev. 2003 Dec;27(5):629-49 [14638416] Genome Res. 2003 Dec;13(12):2519-32 [14656960] Br J Cancer. 2004 Jan 26;90(2):510-4 [14735201] Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):101-12 [14734458] Cancer Immun. 2004 Jan 23;4:1 [14738373] Hum Mol Genet. 2004 Apr 1;13 Spec No 1:R103-21 [14749351] Hum Mol Genet. 2004 Apr 1;13 Spec No 1:R57-64 [14764619] Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3077-82 [14973187] Genome Res. 2004 Apr;14(4):693-9 [15060012] Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4469-74 [9539761] Nat Genet. 1998 Oct;20(2):175-9 [9771711] Genes Dev. 1998 Dec 15;12(24):3831-42 [9869637] Cancer Lett. 1999 Jun 1;140(1-2):227-34 [10403563] Hum Genet. 2005 Feb;116(3):179-85 [15592687] FEBS Lett. 2005 Jan 31;579(3):604-8 [15670815] Nature. 2005 Mar 17;434(7031):325-37 [15772651] Hum Genet. 2005 Aug;117(4):307-16 [15906096] Mol Cell Biol. 2000 Jan;20(1):54-60 [10594008] Cancer Res. 1999 Dec 15;59(24):6223-9 [10626816] Clin Cancer Res. 1999 Dec;5(12):4013-20 [10632333] Biol Reprod. 2000 Aug;63(2):469-81 [10906052] Trends Genet. 2000 Sep;16(9):418-20 [10973072] Mol Cell Biol. 2000 Dec;20(23):9068-75 [11074004] Mol Genet Metab. 2000 Nov;71(3):463-9 [11073713] Biol Reprod. 2001 Jan;64(1):345-58 [11133693] J Surg Res. 2001 Jun 15;98(2):76-80 [11397121] Genomics. 2002 Jan;79(1):41-50 [11827456] Genome Res. 2002 Apr;12(4):656-64 [11932250] Nat Rev Genet. 2002 Apr;3(4):262-73 [11967551] Prostate. 2002 Jun 1;52(1):12-9 [11992616] Science. 2002 Aug 9;297(5583):1003-7 [12169732] Blood. 2003 Feb 1;101(3):955-60 [12393489] Nucleic Acids Res. 2003 Mar 15;31(6):e29 [12626728] Int J Cancer. 2003 Jul 1;105(4):454-8 [12712434] Genes Chromosomes Cancer. 2003 Aug;37(4):381-8 [12800149] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hepatitis C virus-NS3P in relation to p53, p21waf, mdm2, p21-ras and c-erbB2 in hepatocarcinogenesis. AN - 68730908; 16246194 AB - The non-structural protein 3 (NS3P) of hepatitis C virus (HCV) genome was linked to the neoplastic transformation of normal hepatocytes in chronically infected patients. However, the exact mechanisms involved in this process are unidentified yet, especially in the Egyptian population where the commonest type is genotype 4. We investigated 32 HCV reverse transcriptase-polymerase chain reaction (RT-PCR) positive hepatocellular carcinoma (HCC) cases and 18 morphologically normal hepatic tissues distant to tumors (MNT) for the correlation between HCV-NS3P, p53, p21(waf), mdm2, p21ras and c-erbB2 and DNA content by immunohistochemistry and image analysis. The NS3P expression was lower in HCC (65.6%) than in MNT (94.4%) patients. The expression level of studied genes in HCC was: p53 (56.25%), p21(waf) (43.7%), mdm2 (59.4%), p21-ras (73.3%) and c-erbB2 (75%). Whereas in MNT, it was 22.2, 61.1, 44.4, 41.2 and 77.8%, respectively. The NS3P expression showed a significant correlation with the presence of cirrhosis, chronic active hepatitis (CAH) and tumor grade (P < 0.05). c-erbB2 overexpression and p21(waf) loss were higher in MNT than in HCC patients, however, this did not reach a statistically significant level. There was a statistically significant correlation between NS3P, c-erbB2 and p21(waf) (P < 0.01). There was also a significant correlation between p21(waf) loss and CAH (P = 0.01) as well as between mdm2, c-erbB2 and cirrhosis (P = 0.025 and 0.001) in HCC cases. There was a statistically significant difference in the ploidy status between HCC and MNT, but there was no significant relationship between the ploidy status and other clinicopathological features. The carcinogenic effect of NS3P is probably exerted at an early stage of HCC possibly through a pathway involving c-erbB2 and p21(waf) alterations. In contrast, p53, p21ras and mdm2 alterations are late events in hepatocarcinogenesis and are usually associated with an aggressive phenotype. JF - Journal of gastroenterology and hepatology AU - Bahnassi, Abeer A AU - Zekri, Abdel-Rahman N AU - El-Houssini, Soumaya AU - Mokhtar, Nadia M AU - Abdel-Aziz, Asraf O AU - Sherif, Ghada M AU - El-Mishad, Abla M AU - Khaled, Hussein M AD - Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt. Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 1731 EP - 1740 VL - 20 IS - 11 SN - 0815-9319, 0815-9319 KW - CDKN1A protein, human KW - 0 KW - Cyclin-Dependent Kinase Inhibitor p21 KW - DNA, Neoplasm KW - NS3 protein, hepatitis C virus KW - Proto-Oncogene Proteins KW - Tumor Suppressor Protein p53 KW - Viral Nonstructural Proteins KW - MDM2 protein, human KW - EC 2.3.2.27 KW - Proto-Oncogene Proteins c-mdm2 KW - Receptor, ErbB-2 KW - EC 2.7.10.1 KW - Serine Endopeptidases KW - EC 3.4.21.- KW - Proto-Oncogene Proteins p21(ras) KW - EC 3.6.5.2 KW - Index Medicus KW - Proto-Oncogene Proteins p21(ras) -- metabolism KW - Receptor, ErbB-2 -- metabolism KW - Humans KW - Aged KW - Child KW - Tumor Suppressor Protein p53 -- metabolism KW - Adult KW - Cyclin-Dependent Kinase Inhibitor p21 -- metabolism KW - DNA, Neoplasm -- genetics KW - Middle Aged KW - Proto-Oncogene Proteins c-mdm2 -- metabolism KW - Adolescent KW - Ploidies KW - Female KW - Male KW - Viral Nonstructural Proteins -- genetics KW - Serine Endopeptidases -- metabolism KW - Carcinoma, Hepatocellular -- etiology KW - Serine Endopeptidases -- genetics KW - Carcinoma, Hepatocellular -- genetics KW - Hepatitis C, Chronic -- complications KW - Proto-Oncogene Proteins -- metabolism KW - Liver Neoplasms -- etiology KW - Viral Nonstructural Proteins -- metabolism KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68730908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+gastroenterology+and+hepatology&rft.atitle=Hepatitis+C+virus-NS3P+in+relation+to+p53%2C+p21waf%2C+mdm2%2C+p21-ras+and+c-erbB2+in+hepatocarcinogenesis.&rft.au=Bahnassi%2C+Abeer+A%3BZekri%2C+Abdel-Rahman+N%3BEl-Houssini%2C+Soumaya%3BMokhtar%2C+Nadia+M%3BAbdel-Aziz%2C+Asraf+O%3BSherif%2C+Ghada+M%3BEl-Mishad%2C+Abla+M%3BKhaled%2C+Hussein+M&rft.aulast=Bahnassi&rft.aufirst=Abeer&rft.date=2005-11-01&rft.volume=20&rft.issue=11&rft.spage=1731&rft.isbn=&rft.btitle=&rft.title=Journal+of+gastroenterology+and+hepatology&rft.issn=08159319&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-23 N1 - Date created - 2005-10-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phenotype of ENAM mutations is dosage-dependent. AN - 68728777; 16246937 AB - Five mutations in the ENAM gene have been found to cause hypoplastic amelogenesis imperfecta (AI), with phenotypes ranging from localized enamel pitting in carriers to severe hypoplastic AI. To determine the generality of ENAM mutations in hypoplastic AI, we sequenced the ENAM gene in ten Turkish families segregating autosomal hypoplastic AI. In two families, ENAM mutations were found. A novel nonsense mutation (g.12663C>A; p.S246X) was identified in one family segregating local hypoplastic AI as a dominant trait. Affected individuals in a second family segregating autosomal-recessive AI were compound heterozygotes for a novel insertion mutation (g.12946_12947insAGTCAGTACCAGTACTGTGTC) and a previously described insertion (g.13185_13186insAG) mutation. Heterozygous carriers of either insertion had a localized enamel-pitting phenotype. These findings substantiate that enamel phenotypes of ENAM mutations may be dose-dependent, with generalized hypoplastic AI segregating as a recessive trait and localized enamel pitting segregating as a dominant trait. JF - Journal of dental research AU - Ozdemir, D AU - Hart, P S AU - Firatli, E AU - Aren, G AU - Ryu, O H AU - Hart, T C AD - Clinical Research Core, NIDCR/National Institutes of Health, 10 Center Drive, Building 10, Room 5-2531, Bethesda, MD 20892-1432, USA. Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 1036 EP - 1041 VL - 84 IS - 11 SN - 0022-0345, 0022-0345 KW - Codon, Nonsense KW - 0 KW - Dental Enamel Proteins KW - tuftelin KW - Cytosine KW - 8J337D1HZY KW - Adenine KW - JAC85A2161 KW - Dentistry KW - Index Medicus KW - Pedigree KW - Genes, Dominant -- genetics KW - Genes, Recessive -- genetics KW - Humans KW - Child KW - Sequence Analysis, Protein KW - Phenotype KW - Heterozygote KW - Adolescent KW - Female KW - Mutagenesis, Insertional -- genetics KW - Codon, Nonsense -- genetics KW - Amelogenesis Imperfecta -- genetics KW - Dental Enamel Proteins -- genetics KW - Mutation -- genetics KW - Gene Dosage -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68728777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+dental+research&rft.atitle=Phenotype+of+ENAM+mutations+is+dosage-dependent.&rft.au=Ozdemir%2C+D%3BHart%2C+P+S%3BFiratli%2C+E%3BAren%2C+G%3BRyu%2C+O+H%3BHart%2C+T+C&rft.aulast=Ozdemir&rft.aufirst=D&rft.date=2005-11-01&rft.volume=84&rft.issue=11&rft.spage=1036&rft.isbn=&rft.btitle=&rft.title=Journal+of+dental+research&rft.issn=00220345&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-15 N1 - Date created - 2005-10-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arch Oral Biol. 2003 Aug;48(8):589-96 [12828988] Oral Dis. 2003 Jan;9(1):19-23 [12617253] Crit Rev Oral Biol Med. 2003;14(6):387-98 [14656895] J Med Genet. 2003 Dec;40(12):900-6 [14684688] Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004 Feb;97(2):220-30 [14970781] J Dent Res. 2004 May;83(5):378-83 [15111628] J Med Genet. 2004 Jul;41(7):545-9 [15235027] Acta Odontol Scand. 1982;40(3):135-44 [6957136] Community Dent Oral Epidemiol. 1986 Aug;14(4):211-6 [3461907] J Oral Pathol. 1988 Nov;17(9-10):547-53 [3150442] Ciba Found Symp. 1997;205:175-82; discussion 183-6 [9189624] Adv Dent Res. 1996 Nov;10(2):111-8 [9206327] J Dent Res. 2005 Mar;84(3):278-82 [15723871] J Med Genet. 2005 Mar;42(3):271-5 [15744043] Arch Oral Biol. 2005 Jul;50(7):611-23 [15892947] J Craniofac Genet Dev Biol. 1999 Jul-Sep;19(3):148-56 [10589396] Hum Mol Genet. 2001 Aug 1;10(16):1673-7 [11487571] Arch Oral Biol. 2002 Apr;47(4):255-60 [11922868] Arch Oral Biol. 2002 Apr;47(4):261-5 [11922869] Hum Mol Genet. 2002 May 1;11(9):1069-74 [11978766] J Dent Res. 2002 Nov;81(11):738-42 [12407086] Connect Tissue Res. 2003;44 Suppl 1:72-8 [12952177] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In situ expression of brain-derived neurotrophic factor or neurotrophin-3 promotes sprouting of cortical serotonergic axons following a neurotoxic lesion. AN - 68713819; 16206279 AB - Neurotrophins promote sprouting and elongation of central nervous system (CNS) axons following injury. Consequently, it has been suggested that neurotrophins could be used to repair the CNS by inducing axonal sprouting from nearby intact axons, thereby compensating for the loss of recently injured axons. We tested whether long-term overexpression of neurotrophins in the rat cortex would induce sprouting of cortical serotonergic axons following a neurotoxic injury. After a single subcutaneous injection of para-chloroamphetamine (PCA; 9 mg/ml) that lesions the majority of serotonergic axons in the rat cortex, we injected adenoviral vectors containing cDNAs for brain-derived neurotrophic factor (Adv.BDNF), neurotrophin-3 (Adv.NT-3), or nerve growth factor (Adv.NGF) into the rat frontal cortex. Nine days later, we measured significant increases in the concentration of the respective neurotrophins surrounding the vector injection sites, as measured by ELISA. Immunohistochemical localization of serotonin revealed a fourfold increase in the density of serotonergic fibers surrounding the injection sites of Adv.BDNF and Adv.NT-3, corresponding to a 50% increase in cortical serotonin concentration, compared with a control vector containing the cDNA for enhanced green fluorescent protein (Adv.EGFP). In contrast, there was no difference in serotonergic fiber density or cortical serotonin concentration surrounding the injection of Adv.NGF compared with Adv.EGFP. These data demonstrate that localized overexpression of BDNF or NT-3, but not NGF, is sufficient to promote sprouting of serotonergic axons in the cortex following an experimental neurotoxic injury. Copyright (c) 2005 Wiley-Liss, Inc. JF - Journal of neuroscience research AU - Grider, M H AU - Mamounas, L A AU - Le, W AU - Shine, H D AD - Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, and NINDS, NIH, Bethesda, MD, USA. Y1 - 2005/11/01/ PY - 2005 DA - 2005 Nov 01 SP - 404 EP - 412 VL - 82 IS - 3 SN - 0360-4012, 0360-4012 KW - Brain-Derived Neurotrophic Factor KW - 0 KW - Neurotoxins KW - Neurotrophin 3 KW - enhanced green fluorescent protein KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Serotonin KW - 333DO1RDJY KW - p-Chloroamphetamine KW - 64-12-0 KW - Nerve Growth Factor KW - 9061-61-4 KW - Index Medicus KW - Animals KW - Neural Pathways -- physiopathology KW - Neuronal Plasticity -- genetics KW - Neural Pathways -- metabolism KW - Disease Models, Animal KW - Up-Regulation -- genetics KW - Brain Diseases -- drug therapy KW - Brain Diseases -- metabolism KW - Green Fluorescent Proteins -- genetics KW - Rats KW - Transfection KW - Brain Diseases -- chemically induced KW - Genetic Vectors -- genetics KW - Serotonin -- metabolism KW - Green Fluorescent Proteins -- metabolism KW - Nerve Growth Factor -- genetics KW - Female KW - Neurotrophin 3 -- genetics KW - Brain-Derived Neurotrophic Factor -- metabolism KW - Growth Cones -- metabolism KW - Neurotrophin 3 -- metabolism KW - Cerebral Cortex -- metabolism KW - Raphe Nuclei -- physiopathology KW - Raphe Nuclei -- metabolism KW - Nerve Regeneration -- genetics KW - Cerebral Cortex -- physiopathology KW - Brain-Derived Neurotrophic Factor -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68713819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroscience+research&rft.atitle=In+situ+expression+of+brain-derived+neurotrophic+factor+or+neurotrophin-3+promotes+sprouting+of+cortical+serotonergic+axons+following+a+neurotoxic+lesion.&rft.au=Grider%2C+M+H%3BMamounas%2C+L+A%3BLe%2C+W%3BShine%2C+H+D&rft.aulast=Grider&rft.aufirst=M&rft.date=2005-11-01&rft.volume=82&rft.issue=3&rft.spage=404&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroscience+research&rft.issn=03604012&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-24 N1 - Date created - 2005-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Motivational effects of cannabinoids and opioids on food reinforcement depend on simultaneous activation of cannabinoid and opioid systems. AN - 68711071; 15812567 AB - Strong functional interactions exist between endogenous cannabinoid and opioid systems. Here, we investigated whether cannabinoid-opioid interactions modulate motivational effects of food reinforcement. In rats responding for food under a progressive-ratio schedule, the maximal effort (break point) expended to obtain 45 mg pellets depended on the level of food deprivation, with free-feeding reducing break points and food-deprivation increasing break points. Delta-9-tetrahydrocannabinol (THC; 0.3-5.6 mg/kg intrapeitoneally (i.p.)) and morphine (1-10 mg/kg i.p.) dose-dependently increased break points for food reinforcement, while the cannabinoid CB1 receptor antagonist rimonabant (SR-141716A; 0.3-3 mg/kg i.p.) and the preferential mu-opioid receptor antagonist naloxone (0.3-3 mg/kg i.p.) dose-dependently decreased break points. THC and morphine only increased break points when food was delivered during testing, suggesting that these treatments directly influenced reinforcing effects of food, rather than increasing behavior in a nonspecific manner. Effects of THC were blocked by rimonabant and effects of morphine were blocked by naloxone, demonstrating that THC's effects depended on cannabinoid CB1 receptor activation and morphine's effects depended on opioid-receptor activation. Furthermore, THC's effects were blocked by naloxone and morphine's effects were blocked by rimonabant, demonstrating that mu-opioid receptors were involved in the effects of THC and cannabinoid CB1 receptors were involved in the effects of morphine on food-reinforced behavior. Thus, activation of both endogenous cannabinoid and opioid systems appears to jointly facilitate motivational effects of food measured under progressive-ratio schedules of reinforcement and this facilitatory modulation appears to critically depend on interactions between these two systems. These findings support the proposed therapeutic utility of cannabinoid agonists and antagonists in eating disorders. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Solinas, Marcello AU - Goldberg, Steven R AD - Preclinical Pharmacology Section, Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD, USA. msolinas@intra.nida.nih.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 2035 EP - 2045 VL - 30 IS - 11 SN - 0893-133X, 0893-133X KW - Analgesics, Non-Narcotic KW - 0 KW - Analgesics, Opioid KW - Cannabinoid Receptor Agonists KW - Cannabinoid Receptor Antagonists KW - Cannabinoids KW - Central Nervous System Stimulants KW - Drug Combinations KW - Narcotics KW - Piperidines KW - Pyrazoles KW - Receptors, Cannabinoid KW - Receptors, Opioid KW - Methamphetamine KW - 44RAL3456C KW - Morphine KW - 76I7G6D29C KW - Dronabinol KW - 7J8897W37S KW - rimonabant KW - RML78EN3XE KW - Index Medicus KW - Eating -- drug effects KW - Conditioning, Operant -- drug effects KW - Animals KW - Drug Interactions KW - Analgesics, Non-Narcotic -- pharmacology KW - Analysis of Variance KW - Central Nervous System Stimulants -- pharmacology KW - Reinforcement Schedule KW - Dose-Response Relationship, Drug KW - Food Deprivation -- physiology KW - Dronabinol -- pharmacology KW - Behavior, Animal KW - Morphine -- pharmacology KW - Rats KW - Piperidines -- pharmacology KW - Pyrazoles -- pharmacology KW - Rats, Sprague-Dawley KW - Analgesics, Opioid -- pharmacology KW - Methamphetamine -- pharmacology KW - Time Factors KW - Male KW - Receptors, Cannabinoid -- physiology KW - Motivation KW - Food KW - Reinforcement (Psychology) KW - Narcotics -- pharmacology KW - Cannabinoids -- pharmacology KW - Receptors, Opioid -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68711071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Motivational+effects+of+cannabinoids+and+opioids+on+food+reinforcement+depend+on+simultaneous+activation+of+cannabinoid+and+opioid+systems.&rft.au=Solinas%2C+Marcello%3BGoldberg%2C+Steven+R&rft.aulast=Solinas&rft.aufirst=Marcello&rft.date=2005-11-01&rft.volume=30&rft.issue=11&rft.spage=2035&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-24 N1 - Date created - 2005-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Curcumin suppresses interleukin 1beta-mediated microsomal prostaglandin E synthase 1 by altering early growth response gene 1 and other signaling pathways. AN - 68709211; 16081677 AB - Curcumin (diferuloylmethane) is one of the phytophenolic compounds found in the turmeric plant with anti-inflammatory and anticarcinogenic activities. One possible mechanism for these activities is the inhibition of prostaglandin (PG) E(2) formation. In this study and other reports, curcumin suppresses interleukin-1beta-induced formation of prostaglandin E(2) in a concentration-dependent manner. Interleukin-1beta-induced microsomal prostaglandin E synthase 1 (mPGES-1) and cyclooxygenase-2 were attenuated by curcumin at the protein and mRNA levels, but a more dramatic inhibition of mPGES-1 expression was observed at lower concentrations of curcumin in A549 human lung epithelial cells. The inhibition of mPGES-1 expression by curcumin shifted the arachidonic acid profile from PGE(2) to PGF(2alpha) and 6-keto-PGF(1alpha) as major metabolites. The expression of early growth response gene 1 (EGR-1), a key transcription factor of cytokine-induced mPGES-1, was inhibited by curcumin. Incubation with siRNA for EGR-1 inhibited interleukin (IL)-1beta-induced mPGES-1, and the controlled expression of EGR-1 increased the mPGES-1 expression. Several proinflammatory signaling molecules, such as nuclear factor kappaB (NF-kappaB) and mitogen-activated protein kinases, are also known to affect curcumin-regulated gene expression. Curcumin inhibited IkappaBalpha phosphorylation and degradation and thus reduced the expression of mPGES-1. Curcumin suppressed cytokine-induced mPGES-1 by inhibiting phosphorylation of Jun N-terminal kinase (JNK)1/2. However, EGR-1 expression was suppressed by lower concentrations of curcumin, as compared with JNK1/2 and IkappaBalpha. These results indicate that curcumin inhibits IL-1beta-induced PGE(2) formation by inhibiting the expression of mPGES-1 that is mediated by suppression of EGR-1 expression as well as NF-kappaB and JNK1/2. JF - The Journal of pharmacology and experimental therapeutics AU - Moon, Yuseok AU - Glasgow, Wayne C AU - Eling, Thomas E AD - Eicosanoid Biochemistry Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 788 EP - 795 VL - 315 IS - 2 SN - 0022-3565, 0022-3565 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Anticarcinogenic Agents KW - Early Growth Response Protein 1 KW - Interleukin-1 KW - NF-kappa B KW - RNA, Small Interfering KW - Arachidonic Acid KW - 27YG812J1I KW - Luciferases KW - EC 1.13.12.- KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - Mitogen-Activated Protein Kinase 9 KW - EC 2.7.1.24 KW - Mitogen-Activated Protein Kinase 8 KW - EC 2.7.11.24 KW - Intramolecular Oxidoreductases KW - EC 5.3.- KW - PTGES protein, human KW - EC 5.3.99.3 KW - Prostaglandin-E Synthases KW - Curcumin KW - IT942ZTH98 KW - Index Medicus KW - Plasmids -- genetics KW - Cyclooxygenase 2 -- genetics KW - Humans KW - Cyclooxygenase 2 -- biosynthesis KW - Cell Line, Tumor KW - Mitogen-Activated Protein Kinase 8 -- metabolism KW - Mitogen-Activated Protein Kinase 9 -- metabolism KW - Reverse Transcriptase Polymerase Chain Reaction KW - Arachidonic Acid -- metabolism KW - Luciferases -- biosynthesis KW - Blotting, Western KW - Cell Survival -- drug effects KW - Transfection KW - RNA, Small Interfering -- pharmacology KW - Luciferases -- genetics KW - NF-kappa B -- metabolism KW - Interleukin-1 -- physiology KW - Intramolecular Oxidoreductases -- metabolism KW - Signal Transduction -- drug effects KW - Microsomes, Liver -- enzymology KW - Anticarcinogenic Agents -- pharmacology KW - Microsomes, Liver -- drug effects KW - Early Growth Response Protein 1 -- genetics KW - Curcumin -- pharmacology KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68709211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Curcumin+suppresses+interleukin+1beta-mediated+microsomal+prostaglandin+E+synthase+1+by+altering+early+growth+response+gene+1+and+other+signaling+pathways.&rft.au=Moon%2C+Yuseok%3BGlasgow%2C+Wayne+C%3BEling%2C+Thomas+E&rft.aulast=Moon&rft.aufirst=Yuseok&rft.date=2005-11-01&rft.volume=315&rft.issue=2&rft.spage=788&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-12 N1 - Date created - 2005-10-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene. AN - 68707748; 16079301 AB - Previously, our laboratory identified activating transcription factor 3 (ATF3) as up-regulated by nonsteroidal anti-inflammatory drugs using microarray analysis of mRNA from human colorectal cancer cells treated with sulindac sulfide. ATF3 is a transcription factor involved in cell growth, apoptosis, and invasion and is induced by a variety of anticancer and dietary compounds. However, the regulation of ATF3 by anticancer agents is not known. The promoter of ATF3 contains several transcription factor binding sites. We identified three putative Egr-1 binding sites in the promoter of ATF3 and report for the first time that the molecular mechanism responsible for the transcriptional regulation of ATF3 by two divergent pharmaceutical compounds, sulindac sulfide and troglitazone, involved the early growth response gene-1 (Egr-1). For example, overexpression of Egr-1 protein induced ATF3 mRNA 3.5-fold and transcriptional activity of an ATF3 promoter construct more than 20-fold. ATF3 and Egr-1 mRNA and protein and ATF3 promoter activity were induced by these compounds, whereas induction of ATF3 by these compounds was blocked by Egr-1 small interfering RNA. Sulindac sulfide and troglitazone regulated ATF3 promoter activity, which was suppressed when the two Egr-1 sites were mutated. These compounds induced phosphorylation of extracellular signal-regulated kinase1/2 (Erk1/2), whereas a dominant-negative inhibitor of mitogen-activate protein kinase kinase (MEK) 1 blocked the induction of ATF3. The MEK1/2 inhibitor PD98059 (2'-amino-3'-methoxyflavone) blocked the induction of ATF3 and Egr-1 mRNA expression and ATF3 promoter activity by these compounds. Therefore, this is a novel first report demonstrating that the expression of ATF3 occurs via Egr-1 downstream of Erk1/2. JF - The Journal of pharmacology and experimental therapeutics AU - Bottone, Frank G AU - Moon, Yuseok AU - Alston-Mills, Brenda AU - Eling, Thomas E AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA. Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 668 EP - 677 VL - 315 IS - 2 SN - 0022-3565, 0022-3565 KW - Activating Transcription Factor 3 KW - 0 KW - Anti-Inflammatory Agents, Non-Steroidal KW - Chromans KW - Early Growth Response Protein 1 KW - Thiazolidinediones KW - Sulindac KW - 184SNS8VUH KW - RNA KW - 63231-63-0 KW - Luciferases KW - EC 1.13.12.- KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - MAP Kinase Kinase 1 KW - EC 2.7.12.2 KW - troglitazone KW - I66ZZ0ZN0E KW - Index Medicus KW - MAP Kinase Kinase 1 -- genetics KW - Mitogen-Activated Protein Kinases -- metabolism KW - Humans KW - Reverse Transcriptase Polymerase Chain Reaction KW - Autoradiography KW - RNA -- biosynthesis KW - Blotting, Western KW - Gene Expression Regulation -- physiology KW - Chromans -- pharmacology KW - Signal Transduction -- drug effects KW - Thiazolidinediones -- pharmacology KW - Sulindac -- pharmacology KW - RNA -- isolation & purification KW - Genes, Reporter KW - Promoter Regions, Genetic -- genetics KW - Luciferases -- genetics KW - Cell Line KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology KW - Densitometry KW - Early Growth Response Protein 1 -- physiology KW - Early Growth Response Protein 1 -- genetics KW - Activating Transcription Factor 3 -- genetics KW - Activating Transcription Factor 3 -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68707748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Transcriptional+regulation+of+activating+transcription+factor+3+involves+the+early+growth+response-1+gene.&rft.au=Bottone%2C+Frank+G%3BMoon%2C+Yuseok%3BAlston-Mills%2C+Brenda%3BEling%2C+Thomas+E&rft.aulast=Bottone&rft.aufirst=Frank&rft.date=2005-11-01&rft.volume=315&rft.issue=2&rft.spage=668&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-12 N1 - Date created - 2005-10-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cannabinoid agonists but not inhibitors of endogenous cannabinoid transport or metabolism enhance the reinforcing efficacy of heroin in rats. AN - 68698420; 15870833 AB - Accumulating evidence suggests that the endogenous cannabinoid system is involved in the reinforcing effects of heroin. In rats intravenously self-administering heroin, we investigated effects of cannabinoid CB1 receptor agonists and compounds that block transport or metabolism of the endogenous cannabinoid anandamide. The natural cannnabinoid CB1 receptor agonist delta-9-tetrahydrocannabinol (THC, 0.3-3 mg/kg i.p.) did not alter self-administration of heroin under a fixed-ratio one (FR1) schedule, except at a high 3 mg/kg dose which decreased heroin self-administration. Under a progressive-ratio schedule, however, THC dose-dependently increased the number of 50 mug/kg heroin injections self-administered per session and the maximal ratio completed (break-point), with peak increases at 1 mg/kg THC. In addition, 1 mg/kg THC increased break-points and injections self-administered over a wide range of heroin injection doses (25-100 microg/kg), indicating an increase in heroin's reinforcing efficacy and not its potency. The synthetic cannabinoid CB1 receptor agonist WIN55,212-2 (0.3-3 mg/kg i.p.) had effects similar to THC under the progressive-ratio schedule. In contrast, AM-404 (1-10 mg/kg i.p.), an inhibitor of transport of anandamide, and URB-597 (0.01-0.3 mg/kg i.p.), an inhibitor of the enzyme fatty acid amide hydrolase (FAAH) that degrades anandamide, or their combination, did not increase reinforcing efficacy of heroin at any dose tested. Thus, activation of cannabinoid CB1 receptors facilitates the reinforcing efficacy of heroin and this appears to be mediated by interactions between cannabinoid CB1 receptors and mu-opioid receptors and their signaling pathways, rather than by an opioid-induced release of endogenous cannabinoids. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Solinas, Marcello AU - Panlilio, Leigh V AU - Tanda, Gianluigi AU - Makriyannis, Alexandros AU - Matthews, Stephanie A AU - Goldberg, Steven R AD - Preclinical Pharmacology Section, Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA. Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 2046 EP - 2057 VL - 30 IS - 11 SN - 0893-133X, 0893-133X KW - Arachidonic Acids KW - 0 KW - Benzamides KW - Benzoxazines KW - Cannabinoid Receptor Modulators KW - Cannabinoids KW - Carbamates KW - Morpholines KW - N-(4-hydroxyphenyl)arachidonylamide KW - Naphthalenes KW - Narcotics KW - cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester KW - Win 55212-2 KW - 5H31GI9502 KW - Heroin KW - 70D95007SX KW - Dronabinol KW - 7J8897W37S KW - Index Medicus KW - Carbamates -- pharmacology KW - Naphthalenes -- pharmacology KW - Reaction Time -- drug effects KW - Animals KW - Drug Interactions KW - Reinforcement Schedule KW - Dose-Response Relationship, Drug KW - Dronabinol -- pharmacology KW - Morpholines -- pharmacology KW - Self Administration -- psychology KW - Behavior, Animal KW - Arachidonic Acids -- pharmacology KW - Rats KW - Rats, Sprague-Dawley KW - Benzamides -- pharmacology KW - Time Factors KW - Male KW - Conditioning, Operant -- drug effects KW - Cannabinoid Receptor Modulators -- agonists KW - Cannabinoids -- agonists KW - Reinforcement (Psychology) KW - Narcotics -- administration & dosage KW - Cannabinoid Receptor Modulators -- antagonists & inhibitors KW - Heroin -- administration & dosage KW - Cannabinoids -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68698420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Cannabinoid+agonists+but+not+inhibitors+of+endogenous+cannabinoid+transport+or+metabolism+enhance+the+reinforcing+efficacy+of+heroin+in+rats.&rft.au=Solinas%2C+Marcello%3BPanlilio%2C+Leigh+V%3BTanda%2C+Gianluigi%3BMakriyannis%2C+Alexandros%3BMatthews%2C+Stephanie+A%3BGoldberg%2C+Steven+R&rft.aulast=Solinas&rft.aufirst=Marcello&rft.date=2005-11-01&rft.volume=30&rft.issue=11&rft.spage=2046&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-24 N1 - Date created - 2005-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Historical limitations of determinant based exposure groupings in the rubber manufacturing industry. AN - 68697214; 16234406 AB - To study the validity of using a cross-sectional industry-wide exposure survey to develop exposure groupings for epidemiological purposes that extend beyond the time period in which the exposure data were collected. Exposure determinants were used to group workers into high, medium, and low exposure groups. The contrast of this grouping and other commonly used grouping schemes based on plant and department within this exposure survey and a previously conducted survey within the same industry (and factories) were estimated and compared. Grouping of inhalable and dermal exposure based on exposure determinants resulted in the highest, but still modest, contrast (epsilon approximately 0.3). Classifying subjects based on a combination of plant and department resulted in a slightly lower contrast (epsilon approximately 0.2). If the determinant based grouping derived from the 1997 exposure survey was used to classify workers in the 1988 survey the average contrast decreased significantly for both exposures (epsilon approximately 0.1). On the contrary, the exposure classification based on plant and department increased in contrast (from epsilon approximately 0.2 to epsilon approximately 0.3) and retained its relative ranking overtime. Although determinant based groupings seem to result in more efficient groupings within a cross-sectional survey, they have to be used with caution as they might result in significant less contrast beyond the studied population or time period. It is concluded that a classification based on plant and department might be more desirable for retrospective studies in the rubber manufacturing industry, as they seem to have more historical relevance and are most likely more accurately recorded historically than information on exposure determinants in a particular industry. JF - Occupational and environmental medicine AU - Vermeulen, R AU - Kromhout, H AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20892, USA. vermeulr@mail.nih.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 793 EP - 799 VL - 62 IS - 11 KW - Air Pollutants, Occupational KW - 0 KW - Dust KW - Rubber KW - 9006-04-6 KW - Index Medicus KW - Inhalation Exposure -- analysis KW - Epidemiologic Methods KW - Air Pollutants, Occupational -- analysis KW - Skin Absorption KW - Humans KW - Epidemiological Monitoring KW - Environmental Monitoring -- methods KW - Industry KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68697214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+environmental+medicine&rft.atitle=Historical+limitations+of+determinant+based+exposure+groupings+in+the+rubber+manufacturing+industry.&rft.au=Vermeulen%2C+R%3BKromhout%2C+H&rft.aulast=Vermeulen&rft.aufirst=R&rft.date=2005-11-01&rft.volume=62&rft.issue=11&rft.spage=793&rft.isbn=&rft.btitle=&rft.title=Occupational+and+environmental+medicine&rft.issn=1470-7926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-15 N1 - Date created - 2005-10-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Occup Hyg. 2000 Jan;44(1):43-56 [10689758] Occup Environ Med. 1997 Oct;54(10):714-9 [9404318] Mutat Res. 2000 Jul 10;468(2):165-71 [10882893] Ann Occup Hyg. 2000 Aug;44(5):325-7 [10930496] Ann Occup Hyg. 2000 Aug;44(5):343-54 [10930498] Risk Anal. 2000 Oct;20(5):653-63 [11110212] Mutat Res. 2001 Jan 25;490(1):27-34 [11152969] Ann Occup Hyg. 2002 Jan;46(1):69-77 [12005135] Ann Occup Hyg. 1993 Apr;37(2):117-34 [8317851] Am Ind Hyg Assoc J. 1993 Nov;54(11):654-62 [8256689] Ann Occup Hyg. 1994 Feb;38(1):3-22 [8161092] Am J Ind Med. 1995 Feb;27(2):171-85 [7755008] Scand J Work Environ Health. 1996 Apr;22(2):94-101 [8738886] Ann Occup Hyg. 1997 Apr;41(2):135-53 [9155236] Ann Occup Hyg. 1997 Jun;41(3):287-96 [9204756] Epidemiology. 1997 Mar;8(2):218-9 [9229220] Ann Occup Hyg. 2000 Jan;44(1):57-66 [10689759] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inability of a fusion protein of IL-2 and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes in patients with melanoma. AN - 68689235; 16224276 AB - Elimination of regulatory T lymphocytes may provide a way to break self-tolerance and unleash the anti-tumor properties of circulating lymphocytes. The use of fusion proteins, which link cytotoxic molecules to receptor targets, provides one approach to this problem. This study examined the ability of a fusion protein of interleukin-2 (IL-2) and diphtheria toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to eliminate regulatory T lymphocytes based on their expression of high-affinity IL-2 receptors. Thirteen patients (12 with metastatic melanoma, 1 with metastatic renal cell carcinoma) were treated at one of the two Food and Drug Administration-approved doses of Denileukin Diftitox (seven patients at 9 microg/kg, six patients at 18 microg/kg). None of the patients experienced an objective clinical response. Foxp3 expression did not decrease significantly overall, although it did decrease minimally among patients receiving 18 microg/kg (-2.01+/-0.618 copies of Foxp3/10(3) copies of beta-actin; P=0.031). Denileukin Diftitox did not decrease the suppressive ability of CD4CD25 cells as quantified by an in vitro co-culture suppression assay. Furthermore, the increased numbers of lymphocytes in patients resulting from treatment with IL-2 were not susceptible to Denileukin Diftitox. Administration of Denileukin Diftitox does not appear to eliminate regulatory T lymphocytes or cause regression of metastatic melanoma. JF - Journal of immunotherapy (Hagerstown, Md. : 1997) AU - Attia, Peter AU - Maker, Ajay V AU - Haworth, Leah R AU - Rogers-Freezer, Linda AU - Rosenberg, Steven A AD - Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1201, USA. PY - 2005 SP - 582 EP - 592 VL - 28 IS - 6 SN - 1524-9557, 1524-9557 KW - Antineoplastic Agents KW - 0 KW - Diphtheria Toxin KW - FOXP3 protein, human KW - Forkhead Transcription Factors KW - Interleukin-2 KW - RNA, Messenger KW - Receptors, Interleukin-2 KW - Recombinant Fusion Proteins KW - denileukin diftitox KW - 25E79B5CTM KW - Index Medicus KW - Kidney Neoplasms -- pathology KW - Kidney Neoplasms -- drug therapy KW - CD8-Positive T-Lymphocytes -- drug effects KW - Humans KW - Carcinoma, Renal Cell -- drug therapy KW - Cell Line, Tumor KW - Receptors, Interleukin-2 -- immunology KW - Gene Expression Regulation, Neoplastic KW - Forkhead Transcription Factors -- genetics KW - RNA, Messenger -- metabolism KW - CD8-Positive T-Lymphocytes -- immunology KW - Adult KW - Carcinoma, Renal Cell -- secondary KW - Neoplasm Metastasis KW - Middle Aged KW - Forkhead Transcription Factors -- metabolism KW - Recombinant Fusion Proteins -- therapeutic use KW - Carcinoma, Renal Cell -- immunology KW - Male KW - Female KW - Kidney Neoplasms -- immunology KW - Skin Neoplasms -- drug therapy KW - T-Lymphocytes, Regulatory -- drug effects KW - Antineoplastic Agents -- administration & dosage KW - Skin Neoplasms -- immunology KW - Melanoma -- secondary KW - Interleukin-2 -- therapeutic use KW - Melanoma -- drug therapy KW - Diphtheria Toxin -- therapeutic use KW - Melanoma -- immunology KW - Antineoplastic Agents -- therapeutic use KW - Skin Neoplasms -- secondary KW - T-Lymphocytes, Regulatory -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68689235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.atitle=Inability+of+a+fusion+protein+of+IL-2+and+diphtheria+toxin+%28Denileukin+Diftitox%2C+DAB389IL-2%2C+ONTAK%29+to+eliminate+regulatory+T+lymphocytes+in+patients+with+melanoma.&rft.au=Attia%2C+Peter%3BMaker%2C+Ajay+V%3BHaworth%2C+Leah+R%3BRogers-Freezer%2C+Linda%3BRosenberg%2C+Steven+A&rft.aulast=Attia&rft.aufirst=Peter&rft.date=2005-11-01&rft.volume=28&rft.issue=6&rft.spage=582&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.issn=15249557&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-28 N1 - Date created - 2005-10-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 2004 Feb 1;172(3):1531-9 [14734731] Am J Health Syst Pharm. 2005 Feb 15;62(4):391-6 [15745891] Novartis Found Symp. 2004;256:149-52; discussion 152-7, 259-69 [15027488] Annu Rev Immunol. 2004;22:531-62 [15032588] Semin Immunol. 2004 Apr;16(2):73-80 [15036230] Semin Immunol. 2004 Apr;16(2):135-43 [15036237] J Immunol. 2004 May 1;172(9):5213-21 [15100259] Br J Haematol. 2004 Jul;126(1):81-4 [15198736] Int Immunol. 2004 Aug;16(8):1189-201 [15237110] Blood. 2004 Aug 15;104(4):1224-6 [15113758] J Clin Oncol. 2004 Oct 15;22(20):4095-102 [15353540] Fed Proc. 1976 Jul;35(9):2067-72 [1084293] Immunogenetics. 1981;14(1-2):15-27 [7035348] J Exp Med. 1988 Feb 1;167(2):612-22 [3126255] J Immunol. 1989 Jan 15;142(2):471-80 [2783437] J Natl Cancer Inst. 2000 Feb 2;92(3):205-16 [10655437] J Exp Med. 2000 Jul 17;192(2):303-10 [10899917] Nat Genet. 2001 Jan;27(1):20-1 [11137993] J Clin Oncol. 2001 Jan 15;19(2):376-88 [11208829] J Immunol. 2001 Aug 1;167(3):1245-53 [11466340] J Clin Oncol. 2001 Aug 1;19(15):3477-82 [11481353] Immunogenetics. 2001 Aug;53(6):435-9 [11685453] Clin Lymphoma. 2000 Sep;1(2):110-6; discussion 117 [11707818] Clin Lymphoma. 2000 Nov;1 Suppl 1:S27-31 [11707860] Curr Opin Pediatr. 2001 Dec;13(6):533-8 [11753102] Arthritis Res. 2002;4(4):241-6 [12106494] J Clin Invest. 2002 Jul;110(2):185-92 [12122110] J Immunol. 2002 Sep 1;169(5):2756-61 [12193750] J Immunol. 2002 Oct 15;169(8):4183-9 [12370347] Science. 2002 Oct 25;298(5594):850-4 [12242449] J Immunol. 2002 Dec 1;169(11):6210-7 [12444126] J Immunother. 2003 Jan-Feb;26(1):85-93 [12514432] Adv Dermatol. 2002;18:29-43 [12528401] Eur J Immunol. 2002 Nov;32(11):3267-75 [12555672] Nat Immunol. 2003 Apr;4(4):330-6 [12612578] Cancer Chemother Biol Response Modif. 2002;20:301-13 [12703211] Expert Opin Biol Ther. 2003 Feb;3(1):179-86 [12718740] Cancer Immun. 2002 Feb 22;2:1 [12747746] Leuk Lymphoma. 2003 Apr;44(4):731-3 [12769354] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8372-7 [12826605] Nat Rev Cancer. 2003 Sep;3(9):666-75 [12951585] Clin Cancer Res. 2003 Sep 1;9(10 Pt 1):3555-61 [14506141] J Leukoc Biol. 2003 Oct;74(4):471-8 [14519757] Protein Eng. 1987 Dec;1(6):493-8 [3334101] Ann Surg. 1989 Oct;210(4):474-84; discussion 484-5 [2679456] Proc Natl Acad Sci U S A. 1989 Dec;86(23):9485-8 [2594781] Nature. 1992 May 21;357(6375):216-22 [1589020] J Exp Med. 1996 Aug 1;184(2):387-96 [8760792] Essays Biochem. 1995;30:119-31 [8822152] Blood. 1998 Jan 15;91(2):399-405 [9427692] J Immunol. 1998 Feb 1;160(3):1212-8 [9570536] Am J Hematol. 1998 May;58(1):87-90 [9590158] Curr Top Microbiol Immunol. 1998;234:63-81 [9670613] Ann Surg. 1998 Sep;228(3):307-19 [9742914] Methods Mol Med. 2005;109:285-96 [15585928] J Immunol. 2005 Jan 1;174(1):90-8 [15611231] Infect Immun. 2005 Jan;73(1):523-31 [15618192] J Immunother. 2005 Mar-Apr;28(2):120-8 [15725955] J Immunol. 2005 Mar 1;174(5):2591-601 [15728465] J Surg Res. 2005 Mar;124(1):151-7 [15734494] Immunity. 2004 Jan;20(1):107-18 [14738769] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer. AN - 68688511; 16224277 AB - Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is an immunoregulatory molecule expressed by activated T cells and resting CD4CD25 T cells. In patients with advanced melanoma, our group reported that administration of anti-CTLA-4 antibody mediated objective cancer regression in 13% of patients. This study also established that the blockade of CTLA-4 was associated with grade III/IV autoimmune manifestations that included dermatitis, enterocolitis, hepatitis, uveitis, and a single case of hypophysitis. Since this initial report, 7 additional patients with anti-CTLA-4 antibody-induced autoimmune hypophysitis have been accumulated. The characteristics, clinical course, laboratory values, radiographic findings, and treatment of these 8 patients are the focus of this report. JF - Journal of immunotherapy (Hagerstown, Md. : 1997) AU - Blansfield, Joseph A AU - Beck, Kimberly E AU - Tran, Khoi AU - Yang, James C AU - Hughes, Marybeth S AU - Kammula, Udai S AU - Royal, Richard E AU - Topalian, Suzanne L AU - Haworth, Leah R AU - Levy, Catherine AU - Rosenberg, Steven A AU - Sherry, Richard M AD - Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1201, USA. PY - 2005 SP - 593 EP - 598 VL - 28 IS - 6 SN - 1524-9557, 1524-9557 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, CD KW - Antigens, Differentiation KW - CTLA-4 Antigen KW - CTLA4 protein, human KW - Index Medicus KW - Magnetic Resonance Imaging KW - Kidney Neoplasms -- drug therapy KW - Kidney Neoplasms -- pathology KW - Humans KW - Melanoma -- secondary KW - Skin Neoplasms -- pathology KW - Carcinoma, Renal Cell -- drug therapy KW - Skin Neoplasms -- drug therapy KW - Adult KW - Carcinoma, Renal Cell -- secondary KW - Melanoma -- drug therapy KW - Neoplasm Metastasis KW - Middle Aged KW - Male KW - Pituitary Gland -- pathology KW - Antigens, Differentiation -- immunology KW - Autoimmune Diseases -- pathology KW - Autoimmune Diseases -- therapy KW - Autoimmune Diseases -- chemically induced KW - Autoimmune Diseases -- blood KW - Antibodies, Monoclonal -- adverse effects KW - Antibodies, Monoclonal -- administration & dosage KW - Pituitary Gland -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68688511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.atitle=Cytotoxic+T-lymphocyte-associated+antigen-4+blockage+can+induce+autoimmune+hypophysitis+in+patients+with+metastatic+melanoma+and+renal+cancer.&rft.au=Blansfield%2C+Joseph+A%3BBeck%2C+Kimberly+E%3BTran%2C+Khoi%3BYang%2C+James+C%3BHughes%2C+Marybeth+S%3BKammula%2C+Udai+S%3BRoyal%2C+Richard+E%3BTopalian%2C+Suzanne+L%3BHaworth%2C+Leah+R%3BLevy%2C+Catherine%3BRosenberg%2C+Steven+A%3BSherry%2C+Richard+M&rft.aulast=Blansfield&rft.aufirst=Joseph&rft.date=2005-11-01&rft.volume=28&rft.issue=6&rft.spage=593&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.issn=15249557&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-28 N1 - Date created - 2005-10-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4712-7 [12682289] Nature. 2003 May 29;423(6939):506-11 [12724780] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8372-7 [12826605] Singapore Med J. 2004 Feb;45(2):93-4 [14985851] Neurosurgery. 1995 May;36(5):1016-9 [7791966] J Clin Endocrinol Metab. 1995 Aug;80(8):2302-11 [7629223] J Clin Oncol. 2005 Sep 1;23(25):6043-53 [16087944] Science. 1995 Nov 10;270(5238):985-8 [7481803] Immunity. 1995 Nov;3(5):541-7 [7584144] Immunity. 1997 Dec;7(6):885-95 [9430233] J Clin Endocrinol Metab. 1999 Mar;84(3):844-52 [10084559] J Neurol Neurosurg Psychiatry. 1999 Sep;67(3):398-402 [10449568] J Clin Oncol. 2005 Feb 1;23(4):741-50 [15613700] Immunol Today. 1995 Jun;16(6):289-94 [7662098] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Conversion of Fas-resistant to Fas-sensitive MCF-7 breast cancer cells by the synergistic interaction of interferon-gamma and all-trans retinoic acid. AN - 68670557; 16136269 AB - The membrane receptor Fas (Apo-1/CD95) is an important initiator of programmed cell death induced by anti-Fas antibody or Fas ligand. MCF-7 human breast cancer cells have low levels of Fas receptor (FasR) and are resistant to anti-FasR antibody mediated apoptosis, however two naturally occurring substances, interferon and all-trans retinoic acid (AT), act synergistically to enhance antiproliferative processes in these cells, suggesting this combination may also be an effective means for enhancing FasR expression. When this was studied, it was found that IFN-gamma and AT in combination acted synergistically to induce expression of FasR mRNA and FasR protein in a time-dependent and dose-dependent manner. This induction required continuous protein synthesis, and STAT1 protein, but not PKR or TR1 protein, was induced in a manner quantitatively and temporally related to FasR protein induction, and consistent with STAT1 mediation of the synergistic effect of IFN-gamma and AT on FasR expression. FasR-induced cells were resistant to stimulation of apoptosis by anti-FasR antibody, however treatment with cycloheximide rendered these cells sensitive to antibody-induced apoptosis, suggesting endogenous blockade to signaling. These cells did not express caspase 3, or FLIP(L), but strongly expressed the endogenous inhibitor of apoptosis Bcl-2, indicating a type II Fas signaling pathway. Expression of these proteins was not modulated by IFN/AT, however treatment of Fas-induced cells with Bcl-2 specific small interfering RNA (SiRNA) downregulated Bcl-2 protein expression and rendered these cells sensitive to the cytotoxic effects of anti-Fas antibody. These findings indicate that IFN-gamma+AT in combination modulate Fas signaling and provide a novel mechanism for the promotion of cell death in breast cancer cells. JF - Breast cancer research and treatment AU - Danforth, David N AU - Zhu, Yuelin AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. David_Danforth@nih.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 81 EP - 91 VL - 94 IS - 1 SN - 0167-6806, 0167-6806 KW - Antigens, CD95 KW - 0 KW - Proto-Oncogene Proteins c-bcl-2 KW - Tretinoin KW - 5688UTC01R KW - Interferon-gamma KW - 82115-62-6 KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Proto-Oncogene Proteins c-bcl-2 -- drug effects KW - Humans KW - Signal Transduction -- drug effects KW - Apoptosis -- drug effects KW - Cell Line, Tumor KW - Drug Synergism KW - Time Factors KW - Statistics, Nonparametric KW - Breast Neoplasms -- drug therapy KW - Tretinoin -- pharmacology KW - Interferon-gamma -- pharmacology KW - Antigens, CD95 -- drug effects KW - Drug Resistance, Neoplasm -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68670557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Breast+cancer+research+and+treatment&rft.atitle=Conversion+of+Fas-resistant+to+Fas-sensitive+MCF-7+breast+cancer+cells+by+the+synergistic+interaction+of+interferon-gamma+and+all-trans+retinoic+acid.&rft.au=Danforth%2C+David+N%3BZhu%2C+Yuelin&rft.aulast=Danforth&rft.aufirst=David&rft.date=2005-11-01&rft.volume=94&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Breast+cancer+research+and+treatment&rft.issn=01676806&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-27 N1 - Date created - 2005-10-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Induction of suppressors of cytokine signaling (SOCS) in the retina during experimental autoimmune uveitis (EAU): potential neuroprotective role of SOCS proteins. AN - 68666909; 16154209 AB - Suppressors of cytokine signaling (SOCS) are implicated in immunopathogenic mechanisms of autoimmune diseases. We show here that SOCS expression in retina is temporarily correlated with progression of experimental autoimmune uveitis (EAU), an organ-specific autoimmune disease that serves as model of human uveitis. Peak of EAU correlates with highest SOCS genes expression while disease resolution coincides with their down-regulation. Surprisingly, SOCS5 is constitutively expressed in retina. SOCS5 expression increases significantly during EAU and remains elevated even after disease resolution. Our data suggest that cytokine-inducible SOCS members may be involved in negative regulation of inflammatory cytokines activities during EAU, while constitutively expressed SOCS5 may have neuroprotective functions. JF - Journal of neuroimmunology AU - Takase, H AU - Yu, C-R AU - Liu, X AU - Fujimoto, C AU - Gery, I AU - Egwuagu, C E AD - Experimental Immunology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Building 10, Room 10N116, 10 Center Drive, Bethesda, Maryland 20892-1857, USA. Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 118 EP - 127 VL - 168 IS - 1-2 SN - 0165-5728, 0165-5728 KW - Antigens, CD4 KW - 0 KW - Cytokines KW - Neuroprotective Agents KW - RNA, Messenger KW - Retinol-Binding Proteins KW - Suppressor of Cytokine Signaling Proteins KW - interphotoreceptor retinoid binding protein, rat KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Disease Models, Animal KW - Blotting, Western -- methods KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction -- methods KW - Cell Proliferation KW - RNA, Messenger -- biosynthesis KW - Antigens, CD4 -- metabolism KW - Enzyme-Linked Immunosorbent Assay -- methods KW - T-Lymphocytes -- metabolism KW - Electrophoretic Mobility Shift Assay -- methods KW - Time Factors KW - Uveitis -- prevention & control KW - Retina -- metabolism KW - Cytokines -- genetics KW - Retina -- physiology KW - Retina -- drug effects KW - Cytokines -- metabolism KW - Neuroprotective Agents -- pharmacology KW - Suppressor of Cytokine Signaling Proteins -- pharmacology KW - Signal Transduction -- physiology KW - Suppressor of Cytokine Signaling Proteins -- therapeutic use KW - Uveitis -- metabolism KW - Neuroprotective Agents -- therapeutic use KW - Uveitis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68666909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroimmunology&rft.atitle=Induction+of+suppressors+of+cytokine+signaling+%28SOCS%29+in+the+retina+during+experimental+autoimmune+uveitis+%28EAU%29%3A+potential+neuroprotective+role+of+SOCS+proteins.&rft.au=Takase%2C+H%3BYu%2C+C-R%3BLiu%2C+X%3BFujimoto%2C+C%3BGery%2C+I%3BEgwuagu%2C+C+E&rft.aulast=Takase&rft.aufirst=H&rft.date=2005-11-01&rft.volume=168&rft.issue=1-2&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroimmunology&rft.issn=01655728&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-17 N1 - Date created - 2005-10-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differential expression of CYP1A, 2B, and 3A genes in the F344 rat following exposure to a polybrominated diphenyl ether mixture or individual components. AN - 68658074; 16107549 AB - Polybrominated diphenyl ethers (PBDEs), used as flame retardants, have been detected in the environment and in mammalian tissues and fluids. Evidence indicates that PBDE mixtures induce CYPs through aryl hydrocarbon receptor (AhR)-dependent and -independent pathways. The present work has investigated the effects of individual components of a commercial PBDE mixture (DE71) on expression of CYP1A1, a biomarker for activation of the AhR (dioxin-like), and CYP2B and CYP3A, biomarkers for activation of the constitutive androstane and pregnanexreceptors (CAR and PXR), respectively, in the rat. Male F344 rats were dosed orally on three consecutive days with either DE71, PBDE components, 2,2',4,4'-tetraBDE (BDE47), 2,2',4,4',5-pentaBDE (BDE99), 2,2',4,4',5,5'-hexaBDE (BDE153), representative polybrominated dibenzofurans (PBDFs) present in DE71, or reference PCBs. Differential expression of target genes was determined in liver 24 h after the last dose. Quantitative PCR analysis indicated up-regulation of CYP1A1 by DE71; however, the response was weak compared to that for dioxin-like PCB126. Individual PBDE components of DE71 up-regulated CYP1A1 only at the highest administered dose (100 micromol/kg/day). Representative PBDFs efficiently up-regulated CYP1A1; therefore, they, along with other PBDFs and polybrominated dibenzodioxins detected in DE71 and individual PBDE components, may be responsible for most, if not all, dioxin-like properties previously observed for PBDEs. Conversely, PBDEs appear capable of up-regulating CYP2B and CYP3A in rats at doses similar to that for non-dioxin-like PCB153. These results indicate that in vivo PBDE-mediated toxicity would be better categorized by AhR-independent mechanisms, rather than the well-characterized AhR-dependent mechanism associated with exposure to dioxin-like chemicals. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Sanders, J M AU - Burka, L T AU - Smith, C S AU - Black, W AU - James, R AU - Cunningham, M L AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina 27709, USA. sander10@niehs.nih.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 127 EP - 133 VL - 88 IS - 1 SN - 1096-6080, 1096-6080 KW - Complex Mixtures KW - 0 KW - Flame Retardants KW - Halogenated Diphenyl Ethers KW - Phenyl Ethers KW - Polybrominated Biphenyls KW - RNA, Messenger KW - pentabromodiphenyl ether KW - 7REL09ZX35 KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP1A1 KW - Cytochrome P-450 CYP2B1 KW - Cytochrome P-450 CYP3A KW - Oxidoreductases, N-Demethylating KW - EC 1.5.- KW - Index Medicus KW - Rats KW - Administration, Oral KW - Animals KW - Rats, Inbred F344 KW - RNA, Messenger -- metabolism KW - Up-Regulation KW - Reverse Transcriptase Polymerase Chain Reaction KW - Male KW - Oxidoreductases, N-Demethylating -- genetics KW - Cytochrome P-450 CYP2B1 -- genetics KW - Cytochrome P-450 CYP1A1 -- genetics KW - Aryl Hydrocarbon Hydroxylases -- metabolism KW - Phenyl Ethers -- toxicity KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Cytochrome P-450 CYP2B1 -- metabolism KW - Cytochrome P-450 CYP1A1 -- metabolism KW - Aryl Hydrocarbon Hydroxylases -- genetics KW - Polybrominated Biphenyls -- toxicity KW - Oxidoreductases, N-Demethylating -- metabolism KW - Flame Retardants -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68658074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Differential+expression+of+CYP1A%2C+2B%2C+and+3A+genes+in+the+F344+rat+following+exposure+to+a+polybrominated+diphenyl+ether+mixture+or+individual+components.&rft.au=Sanders%2C+J+M%3BBurka%2C+L+T%3BSmith%2C+C+S%3BBlack%2C+W%3BJames%2C+R%3BCunningham%2C+M+L&rft.aulast=Sanders&rft.aufirst=J&rft.date=2005-11-01&rft.volume=88&rft.issue=1&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-15 N1 - Date created - 2005-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A comparison of a prototype PCR assay and hybrid capture 2 for detection of carcinogenic human papillomavirus DNA in women with equivocal or mildly abnormal papanicolaou smears. AN - 68649093; 16203281 AB - We evaluated Hybrid Capture 2 (HC2) and polymerase chain reaction (PCR) results for paired specimens collected at 19,187 visits from 5,026 of 5,060 women participating in the Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesion Triage Study (ALTS). We examined the test agreement between HC2 and PCR detection for any of 13 carcinogenic human papillomavirus types targeted by HC2 and compared clinical performance of the 2 tests for detecting concurrent and follow-up cervical intraepithelial neoplasia (CIN) 3 or cancer. The k value for the 2 assays was 0.65 (95% confidence interval, 0.64-0.66), with 82.7% crude agreement. HC2 was more sensitive (93.6% vs 89.3%; P < .0005) but less specific (41.2% vs 48.5%; P < .0005) than PCR for detecting 2-year cumulative CIN 3 or cancer (n = 503). The presence of multiple types as detected by PCR and/or cytologic abnormality increased the likelihood of an HC2+ result. Increased sensitivity of HC2 compared with PCR was surprising, given the theoretical advantages of PCR-based methods for analytic sensitivity. Smaller amounts of material used in PCR could have limited its sensitivity, but our results demonstrate the importance of optimization and standardization of PCR-based assays for clinical applications. JF - American journal of clinical pathology AU - Schiffman, Mark AU - Wheeler, Cosette M AU - Dasgupta, Abhijit AU - Solomon, Diane AU - Castle, Philip E AU - ALTS Group AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-7234, USA. ; ALTS Group Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 722 EP - 732 VL - 124 IS - 5 SN - 0002-9173, 0002-9173 KW - DNA, Viral KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - Female KW - Papillomavirus Infections -- diagnosis KW - DNA, Viral -- analysis KW - Papillomaviridae -- isolation & purification KW - Polymerase Chain Reaction -- methods KW - Uterine Cervical Neoplasms -- diagnosis KW - Vaginal Smears KW - Papillomaviridae -- genetics KW - Cervical Intraepithelial Neoplasia -- diagnosis KW - Papanicolaou Test UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68649093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+clinical+pathology&rft.atitle=A+comparison+of+a+prototype+PCR+assay+and+hybrid+capture+2+for+detection+of+carcinogenic+human+papillomavirus+DNA+in+women+with+equivocal+or+mildly+abnormal+papanicolaou+smears.&rft.au=Schiffman%2C+Mark%3BWheeler%2C+Cosette+M%3BDasgupta%2C+Abhijit%3BSolomon%2C+Diane%3BCastle%2C+Philip+E%3BALTS+Group&rft.aulast=Schiffman&rft.aufirst=Mark&rft.date=2005-11-01&rft.volume=124&rft.issue=5&rft.spage=722&rft.isbn=&rft.btitle=&rft.title=American+journal+of+clinical+pathology&rft.issn=00029173&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-22 N1 - Date created - 2005-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antitumor activity and distribution of pyrroloiminoquinones in the sponge genus Zyzzya. AN - 68623094; 16009557 AB - A detailed analysis of four different collections of the sponge genus Zyzzya yielded nine pyrroloiminoquinones of the makaluvamine, batzelline, and isobatzelline/damirone classes. Dereplication analyses of additional Zyzzya extracts did not disclose more potent or additional new compounds. Comparative testing of these compounds in the National Cancer Institute's 60 cell line human tumor screen revealed varying levels of potency and differential cytotoxicity, apparently related to the unsaturation levels in and substitution patterns on the core ring system. Further studies on the topoisomerase II-mediated DNA cleavage were conducted. Reductive activation of the pyrroloiminoquinones led to DNA damage in vitro, which correlated with half wave potentials and reversibility parameters. DNA damage could be abrogated by ascorbate. Fluorescence displacement was used to measure intercalation with DNA; intercalation efficiency did not correlate with DNA-damaging proficiency. Makaluvamine H (5) emerged as the most potent and differential of our isolates, roughly comparable to makaluvamines C (in vitro) and I (in vivo). 3,7-Dimethyl guanine was isolated from one of the Zyzzya collections and from the sponge Latrunculia purpurea. JF - Bioorganic & medicinal chemistry AU - Dijoux, Marie-Geneviève AU - Schnabel, Peter C AU - Hallock, Yali F AU - Boswell, Jamie L AU - Johnson, Tanya R AU - Wilson, Jennifer A AU - Ireland, Chris M AU - van Soest, Rob AU - Boyd, Michael R AU - Barrows, Louis R AU - Cardellina, John H AD - Laboratory of Drug Discovery Research and Development, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute-Frederick Cancer Research & Development Center, Frederick, MD 21702-1201, USA. Y1 - 2005/11/01/ PY - 2005 DA - 2005 Nov 01 SP - 6035 EP - 6044 VL - 13 IS - 21 SN - 0968-0896, 0968-0896 KW - Antineoplastic Agents KW - 0 KW - Pyrroloiminoquinones KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Molecular Structure KW - Animals KW - Spectrometry, Fluorescence KW - Humans KW - DNA -- metabolism KW - DNA -- chemistry KW - Cell Line, Tumor KW - Inhibitory Concentration 50 KW - Magnetic Resonance Spectroscopy KW - DNA -- drug effects KW - Pyrroloiminoquinones -- isolation & purification KW - Antineoplastic Agents -- isolation & purification KW - Porifera -- chemistry KW - Antineoplastic Agents -- chemistry KW - Pyrroloiminoquinones -- chemistry KW - Antineoplastic Agents -- pharmacology KW - Pyrroloiminoquinones -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68623094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+%26+medicinal+chemistry&rft.atitle=Antitumor+activity+and+distribution+of+pyrroloiminoquinones+in+the+sponge+genus+Zyzzya.&rft.au=Dijoux%2C+Marie-Genevi%C3%A8ve%3BSchnabel%2C+Peter+C%3BHallock%2C+Yali+F%3BBoswell%2C+Jamie+L%3BJohnson%2C+Tanya+R%3BWilson%2C+Jennifer+A%3BIreland%2C+Chris+M%3Bvan+Soest%2C+Rob%3BBoyd%2C+Michael+R%3BBarrows%2C+Louis+R%3BCardellina%2C+John+H&rft.aulast=Dijoux&rft.aufirst=Marie-Genevi%C3%A8ve&rft.date=2005-11-01&rft.volume=13&rft.issue=21&rft.spage=6035&rft.isbn=&rft.btitle=&rft.title=Bioorganic+%26+medicinal+chemistry&rft.issn=09680896&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-23 N1 - Date created - 2005-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Twelve-Month Prevalence and Changes in Driving after Drinking: United States, 1991-1992 and 2001-2002 AN - 59984061; 200605891 AB - Background: Drinking & driving has been identified as one of the most important contributors of motor vehicle fatalities. This paper addressed the existing gap in our public health knowledge regarding the current prevalence of driving after drinking & how this has changed over the past decade. Methods: Prevalence rates of drinking & driving in 2001-2002, & changes in those prevalence rates between 1991-1992 & 2001-2002 were examined in two large nationally representative surveys of the U.S. population. Results: Overall, the prevalence of driving after drinking was 2.9% in 2001-2002 representing approximately six million U.S. adults. This rate was about three quarters of the rate observed in 1991-1992 (3.7%), reflecting a 22% reduction. Generally, the male-female differentials in the rate of driving after drinking decreased over the past decade. However, the sex ratios increased substantially for underaged youth over the past decade, reflecting the sharp decrease in prevalence of driving after drinking among 18-20-year-old women. Constant & emerging subgroups at high risk for drinking & driving included Whites, Native Americans, males, underaged young adults & 21-25-year-olds. Conclusions: The results of this study highlighted the need to continue to monitor prevalence & changes in driving after drinking. Results are discussed in the context of strengthening existing prevention & intervention efforts & developing new programs with the sociodemographic differentials observed in this study in mind. Tables, References. [Copyright 2006 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Chou, S Patricia AU - Grant, Bridget F AU - Dawson, Deborah A AU - Stinson, Frederick S AU - Saha, Tulshi AU - Pickering, Roger P AD - Laboratory Epidemiology & Biometry, Division Intramural Clnical & Biological Research, National Instit Alcohol Abuse & Alcoholism, National Instit Health, Dept Health & Human Services, Bethesda, MD pchou@mail.nih.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 223 EP - 230 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 80 IS - 2 SN - 0376-8716, 0376-8716 KW - Alcohol-impaired driving KW - Drinking and driving KW - Sociodemographic characteristics KW - High-risk subgroups KW - Changes in Drinking and Driving KW - Fatalities KW - Drinking Behavior KW - United States of America KW - Young Adults KW - Automobiles KW - Sociodemographic Characteristics KW - article KW - 2079: sociology of health and medicine; substance use/abuse & compulsive behaviors (drug abuse, addiction, alcoholism, gambling, eating disorders, etc.) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59984061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Twelve-Month+Prevalence+and+Changes+in+Driving+after+Drinking%3A+United+States%2C+1991-1992+and+2001-2002&rft.au=Chou%2C+S+Patricia%3BGrant%2C+Bridget+F%3BDawson%2C+Deborah+A%3BStinson%2C+Frederick+S%3BSaha%2C+Tulshi%3BPickering%2C+Roger+P&rft.aulast=Chou&rft.aufirst=S&rft.date=2005-11-01&rft.volume=80&rft.issue=2&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2005.03.013 LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-28 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Automobiles; Drinking Behavior; Sociodemographic Characteristics; United States of America; Young Adults; Fatalities DO - http://dx.doi.org/10.1016/j.drugalcdep.2005.03.013 ER - TY - JOUR T1 - Reducing HIV/AIDS and Criminal Justice Involvement in African Americans as a Consequence of Drug Abuse AN - 57147708; 200602337 AB - Despite a similarity in drug use across ethnic groups in the United States, there are differences in the impact of drug involvement on the health and well being of racial/ethnic minority groups. For instance, minority and ethnic groups are at higher risk for addiction than their white counterparts. African Americans have disproportionately experienced the negative impacts of substance use, including high addiction rates, HIV/AIDS infection rates and criminal justice involvement. D. Miller JF - Journal of Health Care for the Poor and Underserved AU - Beatty, Lula AU - Jones, Dionne AU - Doctor, LeKhessa AD - Special Populations Office, National Instit Drug Abuse, National Instits Health, Bethesda, MD lbeatty@nida.nih.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 1 EP - 5 VL - 16 IS - supp B SN - 1049-2089, 1049-2089 KW - Black American people KW - Criminal justice KW - AIDS KW - HIV KW - Drug addiction KW - Drug abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57147708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.atitle=Reducing+HIV%2FAIDS+and+Criminal+Justice+Involvement+in+African+Americans+as+a+Consequence+of+Drug+Abuse&rft.au=Beatty%2C+Lula%3BJones%2C+Dionne%3BDoctor%2C+LeKhessa&rft.aulast=Beatty&rft.aufirst=Lula&rft.date=2005-11-01&rft.volume=16&rft.issue=supp+B&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.issn=10492089&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-04-07 N1 - Last updated - 2016-09-27 N1 - CODEN - JHCUEK N1 - SubjectsTermNotLitGenreText - Black American people; Drug abuse; Drug addiction; HIV; AIDS; Criminal justice ER - TY - JOUR T1 - Oral Language and Reading: Reply to Bracken (2005) AN - 57147221; 200604056 AB - Early language competence in preschool relates both directly & indirectly to elementary school reading in both 1st & 3rd grades. Further, comprehensive language skills are more strongly related to early reading than are vocabulary scores alone. In response to a challenge by S. A. Bracken (2005), the current article reaffirms the National Institute of Child Health & Human Development Early Child Care Research Network's (2005) findings. 9 References. [Copyright 2005 American Psychological Association] JF - Developmental Psychology AU - Steering Committee AD - Steering Committee; National Instit of Child Health & Human Development Early Child Care Research Network, NICHD Rockville, MD Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 1000 EP - 1002 VL - 41 IS - 6 SN - 0012-1649, 0012-1649 KW - emergent literacy, language, literacy KW - Young children KW - Language skills KW - Preschool children KW - Early childhood education KW - Literacy skills KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57147221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+Psychology&rft.atitle=Oral+Language+and+Reading%3A+Reply+to+Bracken+%282005%29&rft.au=Steering+Committee&rft.aulast=Steering+Committee&rft.aufirst=&rft.date=2005-11-01&rft.volume=41&rft.issue=6&rft.spage=1000&rft.isbn=&rft.btitle=&rft.title=Developmental+Psychology&rft.issn=00121649&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-04-07 N1 - Last updated - 2016-09-27 N1 - CODEN - DEVPA9 N1 - SubjectsTermNotLitGenreText - Preschool children; Young children; Language skills; Literacy skills; Early childhood education ER - TY - JOUR T1 - Validation of Scales Measuring Attitudes and Norms Related to Mammography Screening in Women Veterans AN - 57143080; 200605812 AB - Validation of psychosocial measures for use in mammography screening research has been given inadequate attention in the literature. The authors report on the validation of 5 measures examining 4 attitudinal constructs (i.e., pros, cons, outcome expectations, & cancer worries) & 1 social influence construct (i.e., subjective norms) in a 22-item inventory. The study participants consisted of a national, randomly sampled population of women veterans (n = 2,910). After minor revision of scales, the authors found independent measures for 4 constructs: pros, cons, cancer worries, & subjective norms. The authors concluded that these scales have acceptable psychometric properties; support construct validity; & provide brief, reliable, & valid measures of attitudes toward & norms regarding mammography screening. These scales may be useful for intervention research. 5 Tables, 1 Figure, 1 Appendix, 79 References. [Copyright 2005 The American Psychological Association.] JF - Health Psychology AU - Tiro, Jasmin A AU - Diamond, Pamela M AU - Perz, Catherine A AU - Fernandez, Maria AU - Rakowski, William AU - DiClemente, Carlo C AU - Vernon, Sally W AD - Division Cancer Control & Population Sciences, National Cancer Instit, Bethesda, MD tiroj@mail.nih.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 555 EP - 566 PB - American Psychological Association, Washington DC VL - 24 IS - 6 SN - 0278-6133, 0278-6133 KW - mammography, attitudes, subjective norms, construct validation KW - Norms KW - Attitudes KW - Mammography KW - Women KW - Construct validity KW - Psychometrics KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57143080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Psychology&rft.atitle=Validation+of+Scales+Measuring+Attitudes+and+Norms+Related+to+Mammography+Screening+in+Women+Veterans&rft.au=Tiro%2C+Jasmin+A%3BDiamond%2C+Pamela+M%3BPerz%2C+Catherine+A%3BFernandez%2C+Maria%3BRakowski%2C+William%3BDiClemente%2C+Carlo+C%3BVernon%2C+Sally+W&rft.aulast=Tiro&rft.aufirst=Jasmin&rft.date=2005-11-01&rft.volume=24&rft.issue=6&rft.spage=555&rft.isbn=&rft.btitle=&rft.title=Health+Psychology&rft.issn=02786133&rft_id=info:doi/10.1037%2F0278-6133.24.6.555 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-05-02 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Mammography; Attitudes; Psychometrics; Women; Construct validity; Norms DO - http://dx.doi.org/10.1037/0278-6133.24.6.555 ER - TY - JOUR T1 - Unraveling Health Disparities: Examining the Dimensions of Hypertension and Diabetes through Community Engagement AN - 57119655; 200602254 AB - The contexts of people's lives can perpetuate racial & ethnic health disparities. In this work, community members from four racial/ethnic groups (Hispanic, Native American, African American, Asian) engaged in an investigative process to analyze their own life conditions, & to explore dimensions of their health behaviors & lifestyles when managing diabetes &/or hypertension. Principal conclusions of the researchers: (1) Respondents were knowledgeable about their health conditions, but had no knowledge of health disparities. (2) Respondents felt the media portrays members of racial/ethnic minorities as hopeless & helpless; this discourages them from believing they can live healthier or better lives. (3) The over-abundance of fast food & unhealthy food eateries in minority communities contradicts the advice of the public health industry. (4) The majority of all respondents were in one of two stages relative to their willingness to change unhealthy behaviors: not interested or already doing it. 9 Figures, 1 Appendix. [Reprinted by permission of Sage Publications Inc., copyright 2005.] JF - Journal of Health Care for the Poor and Underserved AU - Anderson, Julia B AD - National Instit Child Health & Human Development, National Instits Health, Bethesda, MD Andersju@mail.nih.gov Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 91 EP - 117 VL - 16 IS - supplement A SN - 1049-2089, 1049-2089 KW - Health disparities, community-based participatory research, stages of change, health attitudes and beliefs KW - Health inequalities KW - Health beliefs KW - Community participation KW - Ethnic groups KW - Hypertension KW - Diabetes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57119655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.atitle=Unraveling+Health+Disparities%3A+Examining+the+Dimensions+of+Hypertension+and+Diabetes+through+Community+Engagement&rft.au=Anderson%2C+Julia+B&rft.aulast=Anderson&rft.aufirst=Julia&rft.date=2005-11-01&rft.volume=16&rft.issue=supplement+A&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.issn=10492089&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-04-07 N1 - Last updated - 2016-09-27 N1 - CODEN - JHCUEK N1 - SubjectsTermNotLitGenreText - Ethnic groups; Community participation; Health inequalities; Health beliefs; Diabetes; Hypertension ER - TY - JOUR T1 - Oral language and reading: reply to Bracken (2005) AN - 38200459; 2988851 AB - Early language competence in preschool relates both directly and indirectly to elementary school reading in both 1st and 3rd grades. Further, comprehensive language skills are more strongly related to early reading than are vocabulary scores alone. In response to a challenge by S. A. Bracken (2005), the current article reaffirms the National Institute of Child Health and Human Development Early Child Care Research Network's (2005) findings. Reprinted by permission of the American Psychological Association JF - Developmental psychology Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 1000 EP - 1002 VL - 41 IS - 6 SN - 0012-1649, 0012-1649 KW - Sociology KW - Reading KW - Oral tradition KW - Psychology KW - Language KW - Literacy KW - Public policy KW - Developmental psychology KW - Child development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/38200459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+psychology&rft.atitle=Oral+language+and+reading%3A+reply+to+Bracken+%282005%29&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2005-11-01&rft.volume=41&rft.issue=6&rft.spage=1000&rft.isbn=&rft.btitle=&rft.title=Developmental+psychology&rft.issn=00121649&rft_id=info:doi/10.1037%2F0012-1649.41.6.1000 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 8978 12867; 7226; 10627 11713; 2197 2212 6075 3483; 7454 7353 4049; 3518 10404; 10472; 10404 DO - http://dx.doi.org/10.1037/0012-1649.41.6.1000 ER - TY - JOUR T1 - Theoretical and methodological issues in studying families AN - 38195231; 2986068 JF - Journal of marriage and the family AU - White, Lynn AU - Matthews, Sarah H AU - Furstenberg, Frank F AU - Voydanoff, Patricia AU - LaRossa, Ralph AU - MacMillan, Ross AU - Copher, Ronda AU - O'Brien, Marion AU - Hofferth, Sandra L AU - Seltzer, Judith A AU - Bachrach, Christine A AU - Bianchi, Suzanne M AU - Bledsoe, Caroline H AU - Casper, Lynne M AU - Chase-Lansdale, P Lindsay AU - DiPrete, Thomas A AU - Hotz, V Joseph AU - Morgan, S Philip AU - Sanders, Seth G AU - Thomas, Duncan AU - Cheng, Simon AU - Powell, Brian AU - Small, Stephen A AU - Uttal, Lynet AU - Dodson, Lisa AU - Schmalzbauer, Leah AU - Saltzman, Linda E AU - Mahendra, Reshma R AU - Ikeda, Robin M AU - Ingram, Eben M AU - Roosa, Mark W AU - Deng, Shiying AU - Nair, Rajni L AU - Burrell, Ginger Lockhart AU - Manning, Wendy D AU - Smock, Pamela J AU - Ganong, Lawrence AU - Coleman, Marilyn AU - Acock, Alan C AU - Wu, Zheng AU - Lyons, Karen S AU - Sayer, Aline G AU - Johnson, David AU - Stolz, Heidi E AU - Barber, Brian K AU - Olsen, Joseph A AD - University of Nebraska ; Cleveland State University ; University of Pennsylvania ; University of Dayton ; Georgia State University ; University of Minnesota ; University of North Carolina ; University of Maryland ; University of California ; National Institute of Child Health and Human Development ; Northwestern University ; University of Southern California ; Columbia University ; Duke University ; University of Connecticut ; Indiana University ; University of Wisconsin ; Boston College ; Montana State University ; Centers for Disease Control and Prevention ; Arizona State University ; Bowling Green State University ; University of Michigan ; University of Missouri ; Oregon State University ; University of Victoria Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 791 EP - 1092 VL - 67 IS - 4 SN - 0022-2445, 0022-2445 KW - Sociology KW - Anthropology KW - Longitudinal studies KW - Qualitative analysis KW - Measurement KW - Parent-child relations KW - Statistical analysis KW - Interracial marriages KW - Linear models KW - Sociological theory KW - Research methods KW - Regression analysis KW - Family relations KW - Applied research KW - Data collection KW - Intergenerational relations KW - Action research KW - U.S.A. KW - Data analysis KW - Error KW - Methodology KW - Family studies KW - Social science research KW - Cohabitation KW - Poverty KW - Demographic change KW - Domestic violence KW - Dyad KW - Bias KW - Homosexuals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/38195231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+marriage+and+the+family&rft.atitle=Theoretical+and+methodological+issues+in+studying+families&rft.au=White%2C+Lynn%3BMatthews%2C+Sarah+H%3BFurstenberg%2C+Frank+F%3BVoydanoff%2C+Patricia%3BLaRossa%2C+Ralph%3BMacMillan%2C+Ross%3BCopher%2C+Ronda%3BO%27Brien%2C+Marion%3BHofferth%2C+Sandra+L%3BSeltzer%2C+Judith+A%3BBachrach%2C+Christine+A%3BBianchi%2C+Suzanne+M%3BBledsoe%2C+Caroline+H%3BCasper%2C+Lynne+M%3BChase-Lansdale%2C+P+Lindsay%3BDiPrete%2C+Thomas+A%3BHotz%2C+V+Joseph%3BMorgan%2C+S+Philip%3BSanders%2C+Seth+G%3BThomas%2C+Duncan%3BCheng%2C+Simon%3BPowell%2C+Brian%3BSmall%2C+Stephen+A%3BUttal%2C+Lynet%3BDodson%2C+Lisa%3BSchmalzbauer%2C+Leah%3BSaltzman%2C+Linda+E%3BMahendra%2C+Reshma+R%3BIkeda%2C+Robin+M%3BIngram%2C+Eben+M%3BRoosa%2C+Mark+W%3BDeng%2C+Shiying%3BNair%2C+Rajni+L%3BBurrell%2C+Ginger+Lockhart%3BManning%2C+Wendy+D%3BSmock%2C+Pamela+J%3BGanong%2C+Lawrence%3BColeman%2C+Marilyn%3BAcock%2C+Alan+C%3BWu%2C+Zheng%3BLyons%2C+Karen+S%3BSayer%2C+Aline+G%3BJohnson%2C+David%3BStolz%2C+Heidi+E%3BBarber%2C+Brian+K%3BOlsen%2C+Joseph+A&rft.aulast=White&rft.aufirst=Lynn&rft.date=2005-11-01&rft.volume=67&rft.issue=4&rft.spage=791&rft.isbn=&rft.btitle=&rft.title=Journal+of+marriage+and+the+family&rft.issn=00222445&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - SuppNotes - Collection of 21 articles N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4783; 548 10902; 1168 10902; 10519 3279 971 3286; 10739 12228 10919; 12224 971; 3279 971 3286; 3286; 7419 8163; 7541 7537 971; 7854; 7994; 10919; 3782 5636 5676 971; 1565 1362 2688 2449 10404; 4387; 12004 12008; 11919 10902; 3407 3412 9859; 4777 6093; 9178 4777 6093 6823; 3708 13325; 9962; 5971; 6826 7748 6823; 6645 6823; 2454 6823 6040 5676; 433 293 14 ER - TY - JOUR T1 - Explaining family change and variation: challenges for family demographers AN - 38193431; 2985883 AB - Twenty years ago, the National Institute of Child Health and Human Development (NICHD) issued a request for proposals that resulted in the National Survey of Families and Households (NSFH), a unique survey valuable to a wide range of family scholars. This paper describes the efforts of an interdisciplinary group of family demographers to build on the progress enabled by the NSFH and many other theoretical and methodological innovations. Our work, also supported by NICHD, will develop plans for research and data collection to address the central question of what causes family change and variation. We outline the group's initial assessments of orienting frameworks, key aspects of family life to study, and theoretical and methodological challenges for research on family change. Finally, we invite family scholars to follow our progress and to help develop this shared public good. Reprinted by permission of National Council on Family Relations JF - Journal of marriage and the family AU - Seltzer, Judith A AU - Bachrach, Christine A AU - Bianchi, Suzanne M AU - Bledsoe, Caroline H AU - Casper, Lynne M AU - Chase-Lansdale, P Lindsay AU - DiPrete, Thomas A AU - Hotz, V Joseph AU - Morgan, S Philip AU - Sanders, Seth G AU - Thomas, Duncan AD - University of California ; National Institute of Child Health and Human Development ; University of Maryland ; Northwestern University ; University of Southern California ; Columbia University ; Duke University Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 908 EP - 925 VL - 67 IS - 4 SN - 0022-2445, 0022-2445 KW - Sociology KW - Anthropology KW - Social science research KW - Data collection KW - Interdisciplinary research KW - Research methods KW - Demographic change KW - Methodology KW - Family studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/38193431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+marriage+and+the+family&rft.atitle=Explaining+family+change+and+variation%3A+challenges+for+family+demographers&rft.au=Seltzer%2C+Judith+A%3BBachrach%2C+Christine+A%3BBianchi%2C+Suzanne+M%3BBledsoe%2C+Caroline+H%3BCasper%2C+Lynne+M%3BChase-Lansdale%2C+P+Lindsay%3BDiPrete%2C+Thomas+A%3BHotz%2C+V+Joseph%3BMorgan%2C+S+Philip%3BSanders%2C+Seth+G%3BThomas%2C+Duncan&rft.aulast=Seltzer&rft.aufirst=Judith&rft.date=2005-11-01&rft.volume=67&rft.issue=4&rft.spage=908&rft.isbn=&rft.btitle=&rft.title=Journal+of+marriage+and+the+family&rft.issn=00222445&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 3407 3412 9859; 4783; 6631 10902; 7994; 3286; 10919; 11919 10902 ER - TY - JOUR T1 - High frequency transformation of Cryptococcus neoformans and Cryptococcus gattii by Agrobacterium tumefaciens AN - 20789821; 6633990 AB - Cryptococcus neoformans and Cryptococcus gattii are the caus-ative agents of cryptococcal meningoencephalitis and are amenable to genetic manipulations, making them important models of pathogenic fungi. To improve the efficiency of Agrobacterium tumefaciens mediated transformation (ATMT) in C. neoformans, we optimized various co-cultivation conditions including incubation time and temperature, and bacteria to yeast ratio. ATMT was also applied to both serotypes (B and C) of C. gattii. Transformation efficiency by ATMT in C. neoformans was comparable to either electroporation or biolistic transformation and gave superior efficiencies in serotypes B and C, but unlike Saccharomyces cerevisiae, adenine auxotrophy did not increase ATMT efficiency in C. neoformans or C. gattii. All transformants tested were stable, with a majority containing only a single T-DNA insertion; however, homologous recombination was not observed. Additionally, we isolated adenine auxotrophs containing a single T-DNA insertion in the ADE2 gene for representative serotype B and C strains. JF - Fungal Genetics and Biology AU - McClelland, C M AU - Chang, Y C AU - Kwon-Chung, K J AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA, june_kwon-chung@nih.gov Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 904 EP - 913 VL - 42 IS - 11 SN - 1087-1845, 1087-1845 KW - budding yeast KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Genetics Abstracts KW - Temperature effects KW - Transformation KW - Serotypes KW - Electroporation KW - Auxotrophs KW - ADE2 gene KW - Fungi KW - Meningoencephalitis KW - Auxotrophy KW - Saccharomyces cerevisiae KW - Models KW - Agrobacterium tumefaciens KW - Cryptococcus neoformans KW - Insertion KW - Adenine KW - T-DNA KW - homologous recombination KW - J 02310:Genetics & Taxonomy KW - G 07330:Fungal genetics KW - K 03079:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20789821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fungal+Genetics+and+Biology&rft.atitle=High+frequency+transformation+of+Cryptococcus+neoformans+and+Cryptococcus+gattii+by+Agrobacterium+tumefaciens&rft.au=McClelland%2C+C+M%3BChang%2C+Y+C%3BKwon-Chung%2C+K+J&rft.aulast=McClelland&rft.aufirst=C&rft.date=2005-11-01&rft.volume=42&rft.issue=11&rft.spage=904&rft.isbn=&rft.btitle=&rft.title=Fungal+Genetics+and+Biology&rft.issn=10871845&rft_id=info:doi/10.1016%2Fj.fgb.2005.07.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Transformation; Temperature effects; Serotypes; Electroporation; Auxotrophs; Fungi; ADE2 gene; Meningoencephalitis; Auxotrophy; Models; Insertion; Adenine; T-DNA; homologous recombination; Agrobacterium tumefaciens; Cryptococcus neoformans; Saccharomyces cerevisiae DO - http://dx.doi.org/10.1016/j.fgb.2005.07.003 ER - TY - JOUR T1 - Essential Role of the MyD88 Pathway, but Nonessential Roles of TLRs 2, 4, and 9, in the Adjuvant Effect Promoting Th1-Mediated Autoimmunity AN - 20726475; 7143892 AB - Induction of tissue-specific experimental autoimmune diseases involves an obligatory adjuvant effect to trigger an innate response of a type that will drive a Th1-biased adaptive response. This is achieved by use of CFA containing mycobacteria (Mycobacterium tuberculosis), whose recognition by cells of the innate immune system depends on TLRs that signal through the adaptor molecule MyD88. We examined the role of selected components of the MyD88 pathway in promoting experimental autoimmune uveitis (EAU). Mice deficient in MyD88, TLR2, TLR4, or TLR9 were immunized with the retinal Ag interphotoreceptor retinoid-binding protein in CFA, and their EAU scores and associated immunological responses were examined. MyD88 super(-/-) mice were completely resistant to EAU and had a profound defect in Th1, but not Th2, responses to autoantigen challenge. Surprisingly, TLR2 super(-/-), TLR4 super(-/-), and TLR9 super(-/-) mice were fully susceptible to EAU and had unaltered adaptive responses to interphotoreceptor retinoid-binding protein. Examination of IL-1R family members, which share the common adaptor MyD88 with the TLR family, revealed that IL-1R-deficient mice, but not IL-18-deficient mice, are resistant to EAU and have profoundly reduced Th1 and Th2 responses. These data are compatible with the interpretation that TLR9, TLR4, and TLR2 signaling is either not needed, or, more likely, redundant in the adjuvant effect needed to induce EAU. In contrast, signaling through the IL-1R plays a necessary and nonredundant role in EAU and can by itself account for the lack of EAU development in MyD88 mice. JF - Journal of Immunology AU - Su, Shao Bo AU - Silver, Phyllis B AU - Grajewski, Rafael S AU - Agarwal, Rajeev K AU - Tang, Jun AU - Chan, Chi-Chao AU - Caspi, Rachel R AD - Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 6303 EP - 6310 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 175 IS - 10 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Data processing KW - Retina KW - MyD88 protein KW - TLR9 protein KW - Helper cells KW - Immune system KW - TLR2 protein KW - Autoimmune diseases KW - Adjuvants KW - Autoantigens KW - adaptor proteins KW - interphotoreceptor retinoid-binding protein KW - experimental autoimmune uveitis KW - Lymphocytes T KW - Interleukin 1 receptors KW - Experimental autoimmune uveoretinitis KW - TLR4 protein KW - Toll-like receptors KW - Mycobacterium tuberculosis KW - Signal transduction KW - J 02350:Immunology KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20726475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Essential+Role+of+the+MyD88+Pathway%2C+but+Nonessential+Roles+of+TLRs+2%2C+4%2C+and+9%2C+in+the+Adjuvant+Effect+Promoting+Th1-Mediated+Autoimmunity&rft.au=Su%2C+Shao+Bo%3BSilver%2C+Phyllis+B%3BGrajewski%2C+Rafael+S%3BAgarwal%2C+Rajeev+K%3BTang%2C+Jun%3BChan%2C+Chi-Chao%3BCaspi%2C+Rachel+R&rft.aulast=Su&rft.aufirst=Shao&rft.date=2005-11-01&rft.volume=175&rft.issue=10&rft.spage=6303&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Data processing; Retina; MyD88 protein; Immune system; Helper cells; TLR9 protein; Autoimmune diseases; TLR2 protein; Adjuvants; Autoantigens; adaptor proteins; interphotoreceptor retinoid-binding protein; experimental autoimmune uveitis; Lymphocytes T; Interleukin 1 receptors; Experimental autoimmune uveoretinitis; TLR4 protein; Toll-like receptors; Signal transduction; Mycobacterium tuberculosis ER - TY - JOUR T1 - Estimated Urine pH and Bladder Cancer Risk in a Cohort of Male Smokers (Finland)* AN - 20718660; 6871954 AB - Objective:Low urine pH may be an important risk factor for bladder cancer, although few studies have evaluated this association. We examined the relationship between estimated renal net acid excretion (NAE), an indirect measure of urine pH based on nutrient intake and anthropometry, and bladder cancer risk in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study.Methods: At baseline, 27,096 male smokers 50-69 years old completed a dietary questionnaire that assessed usual frequency of consumption and portion sizes for the previous 12 months, had height and weight measured, and provided a history of smoking. A total of 446 incident bladder cancer cases were identified during up to 17.4 years of follow-up.Results: In multivariate proportional hazards models, the relative risk (RR) for bladder cancer was 1.15 (95% confidence interval (CI)=0.86-1.55) for individuals in the highest (i.e., most acidic) versus the lowest (i.e., least acidic) NAE quintile (p=0.38). Among men who smoked for more than 45 years, there was a suggestion of increased risk with higher NAE levels (RR=1.72, 95% CI=0.96-3.10, p=0.08).Conclusions: These findings do not indicate that urine pH is a major risk factor for bladder cancer, although certain subsets of individuals may be at increased risk. JF - Cancer Causes & Control AU - Wright, Margaret E AU - Michaud, Dominique S AU - Pietinen, Pirjo AU - Taylor, Philip R AU - Virtamo, Jarmo AU - Albanes, Demetrius AD - National Cancer Institute, NIH, DHHS, 6120 Executive Blvd., EPS 212D, Rockville, MD, 20852, USA, wrighmar@mail.nih.gov Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 1117 EP - 1123 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 16 IS - 9 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - Diets KW - urinary bladder KW - Historical account KW - Smoking KW - Finland KW - Urine KW - prevention KW - males KW - Excretion KW - Cancer KW - pH KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20718660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Estimated+Urine+pH+and+Bladder+Cancer+Risk+in+a+Cohort+of+Male+Smokers+%28Finland%29*&rft.au=Wright%2C+Margaret+E%3BMichaud%2C+Dominique+S%3BPietinen%2C+Pirjo%3BTaylor%2C+Philip+R%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius&rft.aulast=Wright&rft.aufirst=Margaret&rft.date=2005-11-01&rft.volume=16&rft.issue=9&rft.spage=1117&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-005-0348-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diets; Smoking; Historical account; urinary bladder; Urine; prevention; males; Excretion; pH; Cancer; Finland DO - http://dx.doi.org/10.1007/s10552-005-0348-9 ER - TY - JOUR T1 - Prevalence of Impaired Fasting Glucose and Its Relationship With Cardiovascular Disease Risk Factors in US Adolescents, 1999-2000 AN - 20717855; 6505410 AB - OBJECTIVE: PEDIATRICS (ISSN 0031 4005). Published in the public domain by the American Academy of Pediatrics.Several studies have reported increases in the occurrence of type 2 diabetes in youths. People with prediabetic states such as impaired fasting glucose (IFG) are at increased risk for developing diabetes and cardiovascular disease (CVD). The objective of this study was to examine the prevalence of IFG and its relationship with overweight and CVD risk factors in a nationally representative sample of US adolescents who were aged 12 to 19 years. METHODS: We used data from the 1999-2000 National Health and Nutrition Examination Survey (NHANES). Adolescents who had fasted for 8 hours or more were included in the study (n = 915). IFG was defined as a fasting glucose of 100 to 125 mg/dL. Participants were classified as overweight when their age- and gender-specific BMI was greater than or equal to 95th percentile and as at-risk for overweight when their BMI was greater than or equal to 85th and <95th percentile. RESULTS: In 1999-2000, the prevalence of IFG in US adolescents was 7.0% and was higher in boys than in girls (10.0% vs 4.0%). Prevalence of IFG was higher in overweight adolescents (17.8%) but was similar in those with normal weight and those who were at risk for overweight (5.4% vs 2.8%). The prevalence of IFG was significantly different across racial/ethnic groups (13.0%, 4.2%, and 7% in Mexican Americans, non-Hispanic black individuals, and non-Hispanic white individuals, respectively). Adolescents with IFG had significantly higher mean hemoglobin A1c, fasting insulin, total and low-density lipoprotein cholesterol, triglycerides, and systolic blood pressure and lower high-density lipoprotein cholesterol than those with normal fasting glucose concentrations. CONCLUSIONS: These data, representing 27 million US adolescents, reveal a very high prevalence of IFG (1 in 10 boys and 1 in 25 girls) among adolescents; the condition affects 1 in every 6 overweight adolescents. Adolescents with IFG have features of insulin resistance and worsened CVD risk factors. Evidence for prevention is still forthcoming in this age group. JF - Pediatrics AU - Williams, Desmond E AU - Cadwell, Betsy L AU - Cheng, Yiling J AU - Cowie, Catherine C AU - Gregg, Edward W AU - Geiss, Linda S AU - Engelgau, Michael M AU - Narayan, KMVenkat AU - Imperatore, Giuseppina AD - Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 1122 EP - 1126 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 116 IS - 5 SN - 0031-4005, 0031-4005 KW - Risk Abstracts KW - Age KW - insulin KW - obesity KW - cholesterol KW - Nutrition KW - USA KW - diabetes mellitus KW - Gender KW - prevention KW - Cardiovascular diseases KW - Adolescents KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20717855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Prevalence+of+Impaired+Fasting+Glucose+and+Its+Relationship+With+Cardiovascular+Disease+Risk+Factors+in+US+Adolescents%2C+1999-2000&rft.au=Williams%2C+Desmond+E%3BCadwell%2C+Betsy+L%3BCheng%2C+Yiling+J%3BCowie%2C+Catherine+C%3BGregg%2C+Edward+W%3BGeiss%2C+Linda+S%3BEngelgau%2C+Michael+M%3BNarayan%2C+KMVenkat%3BImperatore%2C+Giuseppina&rft.aulast=Williams&rft.aufirst=Desmond&rft.date=2005-11-01&rft.volume=116&rft.issue=5&rft.spage=1122&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Age; diabetes mellitus; insulin; Gender; prevention; obesity; Cardiovascular diseases; Nutrition; cholesterol; Ethnic groups; Adolescents; USA ER - TY - JOUR T1 - Immunodeficiency in the Absence of High Viral Load in Pig-Tailed Macaques Infected with Simian Immunodeficiency Virus SIVsun or SIVlhoest AN - 20717842; 6504757 AB - Simian immunodeficiency virus (SIV) is known to result in an asymptomatic infection of its natural African monkey host. However, some SIV strains are capable of inducing AIDS-like symptoms and death upon experimental infection of Asian macaques. To further investigate the virulence of natural SIV isolates from African monkeys, pig-tailed (PT) macaques were inoculated intravenously with either of two recently discovered novel lentiviruses, SIVlhoest and SIVsun. Both viruses were apparently apathogenic in their natural hosts but caused immunodeficiency in PT macaques. Infection was characterized by a progressive loss of CD4 super(+) lymphocytes in the peripheral blood and lymph nodes, generalized lymphoid depletion, a wasting syndrome, and opportunistic infections, such as Mycobacterium avium or Pneumocystis carinii infections. However, unlike SIVsm/mac infection of macaques, SIVlhoest and SIVsun infections in PT macaques were not accompanied by high viral loads during the chronic disease stage. In addition, no significant correlation between the viral load at set point (12 weeks postinfection) and survival could be found. Five out of eight SIVlhoest-infected and three out of four SIVsun-infected macaques succumbed to AIDS during the first 5 years of infection. Thus, the survival of SIVsun- and SIVlhoest-infected animals was significantly longer than that of SIVagm- or SIVsm-infected macaques. All PT macaques maintained strong SIV antibody responses despite progression to SIV-induced AIDS. The development of immunodeficiency in the face of low viremia suggests that SIVlhoest and SIVsun infections of macaques may model unique aspects of the pathogenesis of human immunodeficiency virus infection in humans. JF - Journal of Virology AU - Beer, Brigitte E AU - Brown, Charles R AU - Whitted, Sonya AU - Goldstein, Simoy AU - Goeken, Robert AU - Plishka, Ronald AU - Buckler-White, Alicia AU - Hirsch, Vanessa M AD - Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852 Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 14044 EP - 14056 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 79 IS - 22 SN - 0022-538X, 0022-538X KW - HIV KW - Macaques KW - SIV KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Virology & AIDS Abstracts KW - Experimental infection KW - Acquired immune deficiency syndrome KW - Mycobacterium avium KW - Pneumocystis carinii KW - Macaca KW - Animal models KW - Immunodeficiency KW - Survival KW - Peripheral blood KW - Asymptomatic infection KW - Lymphocytes KW - Lymph nodes KW - Opportunist infection KW - Virulence KW - CD4 antigen KW - Antibodies KW - Lentivirus KW - Human immunodeficiency virus KW - Chronic infection KW - Viremia KW - Simian immunodeficiency virus KW - F 06308:Clinical: AIDS KW - V 22005:AIDS: Epidemiological aspects KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20717842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Immunodeficiency+in+the+Absence+of+High+Viral+Load+in+Pig-Tailed+Macaques+Infected+with+Simian+Immunodeficiency+Virus+SIVsun+or+SIVlhoest&rft.au=Beer%2C+Brigitte+E%3BBrown%2C+Charles+R%3BWhitted%2C+Sonya%3BGoldstein%2C+Simoy%3BGoeken%2C+Robert%3BPlishka%2C+Ronald%3BBuckler-White%2C+Alicia%3BHirsch%2C+Vanessa+M&rft.aulast=Beer&rft.aufirst=Brigitte&rft.date=2005-11-01&rft.volume=79&rft.issue=22&rft.spage=14044&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; Experimental infection; Immunodeficiency; Animal models; Survival; Asymptomatic infection; Peripheral blood; Lymphocytes; Lymph nodes; Opportunist infection; Virulence; Antibodies; CD4 antigen; Chronic infection; Viremia; Pneumocystis carinii; Mycobacterium avium; Lentivirus; Human immunodeficiency virus; Macaca; Simian immunodeficiency virus ER - TY - JOUR T1 - Drinking-Water Nitrate and Health-Recent Findings and Research Needs AN - 20582130; 6737368 AB - Human alteration of the nitrogen cycle has resulted in steadily accumulating nitrate in our water resources. The U.S. maximum contaminant level and World Health Organization guidelines for nitrate in drinking water were promulgated to protect infants from developing methemoglobine-mia, an acute condition. Some scientists have recently suggested that the regulatory limit for nitrate is overly conservative; however, they have not thoroughly considered chronic health outcomes. In August 2004, a symposium on drinking-water nitrate and health was held at the International Society for Environmental Epidemiology meeting to evaluate nitrate exposures and associated health effects in relation to the current regulatory limit. The contribution of drinking-water nitrate toward endogenous formation of N-nitroso compounds was evaluated with a focus toward identifying subpopulations with increased rates of nitrosation. Adverse health effects may be the result of a complex interaction of the amount of nitrate ingested, the concomitant ingestion of nitrosation cofactors and precursors, and specific medical conditions that increase nitrosation. Workshop participants concluded that more experimental studies are needed and that a particularly fruitful approach may be to conduct epidemiologic studies among susceptible subgroups with increased endogenous nitrosation. The few epidemiologic studies that have evaluated intake of nitrosation precursors and/or nitrosation inhibitors have observed elevated risks for colon cancer and neural tube defects associated with drinking-water nitrate concentrations below the regulatory limit. The role of drinking-water nitrate exposure as a risk factor for specific cancers, reproductive outcomes, and other chronic health effects must be studied more thoroughly before changes to the regulatory level for nitrate in drinking water can be considered. JF - Environmental Health Perspectives AU - Ward, M H AU - deKok, TM AU - Levallois, P AU - Brender, J AU - Gulis, G AU - Nolan, B T AU - VanDerslice, J AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., EPS 8104, Bethesda, MD 20892 USA, wardm@mail.nih.gov Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 1607 EP - 1614 VL - 113 IS - 11 SN - 0091-6765, 0091-6765 KW - Pollution Abstracts; Risk Abstracts; Toxicology Abstracts; Aqualine Abstracts; Water Resources Abstracts; Health & Safety Science Abstracts KW - Intakes KW - Water resources KW - Neural tube defects KW - Research Priorities KW - Exposure KW - Subpopulations KW - Nitrogen Cycle KW - Colon cancer KW - Ingestion KW - N-Nitroso compounds KW - Cofactors KW - Epidemiology KW - Water Pollution Effects KW - Nitrogen cycle KW - Standards KW - Nitrosation KW - Contaminants KW - Water Resources KW - Infants KW - Nitrate KW - Organizations KW - Tubes KW - Drinking Water KW - Pollutants KW - Risk factors KW - Inhibitors KW - Nitrates KW - Cancer KW - Risk KW - USA KW - Drinking water KW - Symposium KW - X 24120:Food, additives & contaminants KW - P 2000:FRESHWATER POLLUTION KW - AQ 00008:Effects of Pollution KW - SW 3030:Effects of pollution KW - H 12000:Epidemiology and Public Health KW - R2 23050:Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20582130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Drinking-Water+Nitrate+and+Health-Recent+Findings+and+Research+Needs&rft.au=Ward%2C+M+H%3BdeKok%2C+TM%3BLevallois%2C+P%3BBrender%2C+J%3BGulis%2C+G%3BNolan%2C+B+T%3BVanDerslice%2C+J&rft.aulast=Ward&rft.aufirst=M&rft.date=2005-11-01&rft.volume=113&rft.issue=11&rft.spage=1607&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.8043 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Nitrate; Subpopulations; Water resources; Colon cancer; Neural tube defects; N-Nitroso compounds; Cofactors; Epidemiology; Risk factors; Nitrogen cycle; Nitrosation; Drinking water; Contaminants; Infants; Nitrates; Ingestion; Cancer; Organizations; Intakes; Nitrogen Cycle; Tubes; Risk; Research Priorities; Drinking Water; Pollutants; Exposure; Water Pollution Effects; Inhibitors; Standards; Symposium; Water Resources; USA DO - http://dx.doi.org/10.1289/ehp.8043 ER - TY - JOUR T1 - Mutant Brca2/p53 mice exhibit altered radiation responses in the developing mammary gland AN - 20466071; 7911784 AB - Appropriate balance between proliferation and apoptosis is critical for mammary gland development and is often altered during tumorigenesis. Carcinogens like radiation induce DNA damage and activate protective responses such as cell cycle arrest and apoptosis. We used mice carrying Brca2-/- and/or p53-/- mutations to evaluate the individual and combined effects of these genes on cell proliferation and apoptosis in the developing mammary gland. Mice were exposed to 5Gy of radiation or chamber exposure (controls) followed by injection with BrdU. Mammary glands were collected 6h post-radiation exposure and evaluated for proliferation (BrdU) and apoptosis (TUNEL) in terminal end buds (TEB) and ducts. Under control conditions, the Brca2 mutation reduced proliferation and apoptosis in TEB but not ducts, whereas the p53 mutation reduced apoptosis in TEB and ducts but did not influence proliferation. Despite these alterations in proliferation and/or apoptosis, neither mutation, either individually or combined, significantly altered the overall balance between the two as measured by the proliferation to apoptosis ratio (growth index). Following irradiation, the Brca2 mutation had no significant effect on proliferation or apoptosis, whereas the p53 mutation resulted in reduced apoptosis in TEB and ducts but did not significantly influence proliferation. Neither mutation by itself altered the growth index in the TEB after irradiation although combined Brca2/p53 mutation caused significantly increased proliferation, reduced apoptosis, and an elevated growth index in TEB and ducts. These results reveal both independent and collaborative growth regulatory roles for Brca2 and p53 under normal and adverse environmental conditions. Additionally, we demonstrate the importance of gene-environment interactions by showing that Brca2- and p53-deficient mice can compensate for their genetic deficiencies under control conditions but not after exposure to radiation. We also demonstrate distinct spatial differences in the cellular functions of Brca2 and p53 and show that combined mutation of both genes is more detrimental than loss of either gene alone. JF - Experimental and Toxicologic Pathology AU - Houle, Christopher D AU - Peddada, Shyamal D AU - McAllister, Kimberly A AU - Ward, Toni AU - Malphurs, Jason AU - Gersch, William D AU - Davis, Barbara J AD - Laboratory of Women's Health, National Institute of Environmental Health Sciences, NIH, P.O. Box 12233, Research Triangle Park, NC 27709, USA, choule@epl-inc.com Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 105 EP - 115 PB - Elsevier GmbH, Office Jena, P.O. Box 100537 Jena D-07705 Germany, [mailto:journals@elsevier.com], [URL:http://www.elsevier.de/] VL - 57 IS - 2 SN - 0940-2993, 0940-2993 KW - Toxicology Abstracts KW - Brca2 KW - p53 KW - Apoptosis KW - Proliferation KW - Radiation KW - Mammary gland KW - Post-radiation KW - Tumorigenesis KW - Cell cycle KW - Carcinogens KW - BRCA2 protein KW - Buds KW - p53 protein KW - DNA damage KW - Environmental conditions KW - Cell proliferation KW - Mutation KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20466071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+Toxicologic+Pathology&rft.atitle=Mutant+Brca2%2Fp53+mice+exhibit+altered+radiation+responses+in+the+developing+mammary+gland&rft.au=Houle%2C+Christopher+D%3BPeddada%2C+Shyamal+D%3BMcAllister%2C+Kimberly+A%3BWard%2C+Toni%3BMalphurs%2C+Jason%3BGersch%2C+William+D%3BDavis%2C+Barbara+J&rft.aulast=Houle&rft.aufirst=Christopher&rft.date=2005-11-01&rft.volume=57&rft.issue=2&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Experimental+and+Toxicologic+Pathology&rft.issn=09402993&rft_id=info:doi/10.1016%2Fj.etp.2005.06.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Apoptosis; Post-radiation; Mammary gland; Cell cycle; Tumorigenesis; BRCA2 protein; Carcinogens; p53 protein; Buds; DNA damage; Radiation; Cell proliferation; Environmental conditions; Mutation DO - http://dx.doi.org/10.1016/j.etp.2005.06.001 ER - TY - JOUR T1 - Nanoparticle Formulation Increases Oral Bioavailability of Poorly Soluble Drugs: Approaches, Experimental Evidences and Theory AN - 20368787; 7729187 AB - The increasing frequency at which poorly soluble new chemical entities are being discovered raises concerns in the pharmaceutical industry about drugability associated with erratic dissolution and low bioavailability of these hydrophobic compounds. Nanonization provides a plausible pharmaceutical basis for enhancing oral bioavailability and therapeutic effectiveness of these compounds by increasing their surface area. This paper surveys methods available to pharmaceutical manufacturing nanoparticles, including wet chemical processes, media milling, high pressure homogenization, gas-phase synthesis, and form-in-place processes, and elaborates physicochemical rational and gastrointestinal physiological basis upon which nano-drugs can be readily absorbed. Relevant examples are illustrated to show that nano- drugs permeate Caco-2 cell monolayer fast and are well absorbed into animal systemic circulation with high Tmax and AUC, resulting in oral bioavailability higher than their counterpart micro-drugs. The size-dependent permeability and bioavailability should be given particular consideration in the development of potent and selective drug candidates with poor aqueous solubility. JF - Current Nanoscience AU - Jia, Lee AD - EPN, Rm 8042, 6130 Executive Blvd., National Cancer Institute, NIH, Rockville, MD 20852, USA. Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 237 EP - 243 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 1 IS - 3 SN - 1573-4137, 1573-4137 KW - Biotechnology and Bioengineering Abstracts KW - Permeability KW - Solubility KW - Surface area KW - Dissolution KW - Pharmaceuticals KW - Hydrophobicity KW - Drug development KW - Pressure KW - Media (selective) KW - nanoparticles KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20368787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Nanoscience&rft.atitle=Nanoparticle+Formulation+Increases+Oral+Bioavailability+of+Poorly+Soluble+Drugs%3A+Approaches%2C+Experimental+Evidences+and+Theory&rft.au=Jia%2C+Lee&rft.aulast=Jia&rft.aufirst=Lee&rft.date=2005-11-01&rft.volume=1&rft.issue=3&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=Current+Nanoscience&rft.issn=15734137&rft_id=info:doi/10.2174%2F157341305774642939 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Pharmaceuticals; Drug development; Hydrophobicity; nanoparticles; Solubility; Surface area; Media (selective); Permeability; Dissolution; Pressure DO - http://dx.doi.org/10.2174/157341305774642939 ER - TY - JOUR T1 - Novel Phase I Dose De-escalation Design Trial to Determine the Biological Modulatory Dose of the Antiangiogenic Agent SU5416 AN - 20241799; 7142102 AB - PURPOSE: To determine the biological modulatory dose of SU5416, we employed a novel trial design, where "dose de-escalation" was based on demonstrable biological changes observed at the maximum tolerated dose. If such an effect was shown, dose de-escalation to a predefined dose level would occur to determine if the lower dose exhibited the same amount of pharmacodynamic effect as the higher dose. Experimental Design: Ten patients with advanced solid tumors were enrolled at each dose level. One of the following pharmacodynamic effects was considered significant: (a) a 35% decrease in microvessel density in sequential tumor biopsies and (b) a 35% decrease in blood flow within tumor as assessed by dynamic contrast-enhanced magnetic resonance imaging. In addition, soluble E-selectin, soluble intercellular adhesion molecule, soluble vascular cell adhesion molecule, and plasma vascular endothelial growth factor were measured sequentially. RESULTS: Nineteen patients were enrolled. Sequential tumor biopsies in all evaluable patients showed an increase in microvessel density. Only one patient met the intended pharmacodynamic end point of >35% reduction in blood flow. There was a significant increase in both soluble E-selectin and soluble intercellular adhesion molecule levels pretreatment versus levels at the time of removal of patients from study (P = 0.04 and P = 0.0007, respectively). Levels of serum fibrinogen rose with therapy. There was a trend toward increase in plasma vascular endothelial growth factor levels. CONCLUSION: SU5416 does not result in decreased blood flow in tumors or a decrease in microvessel density. This corresponds to the lack of clinical activity seen with this agent. Our clinical trial design termed dose de-escalation is a novel approach to determine the in vivo biological effects of targeted therapies in cancer patients. JF - Clinical Cancer Research AU - Dowlati, Afshin AU - Robertson, Kelly AU - Radivoyevitch, Tomas AU - Waas, John AU - Ziats, Nicholas P AU - Hartman, Paul AU - Abdul-Karim, Fadi W AU - Wasman, Jay K AU - Jesberger, Jack AU - Lewin, Jonathan AU - McCrae, Keith AU - Ivy, Percy AU - Remick, Scot C AD - Authors' Affiliations: Developmental Therapeutics Program, Case Comprehensive Cancer Center and Division of Hematology/Oncology, Department of Pathology and Radiology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio and National Cancer Institute, Bethesda, Maryland Y1 - 2005/11/01/ PY - 2005 DA - 2005 Nov 01 SP - 7938 EP - 7944 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 11 IS - 21 SN - 1078-0432, 1078-0432 KW - Biotechnology and Bioengineering Abstracts KW - Vascular endothelial growth factor KW - antiangiogenic agents KW - Solid tumors KW - Fibrinogen KW - Magnetic resonance imaging KW - Biopsy KW - Tumors KW - Clinical trials KW - Cell adhesion molecules KW - Pharmacodynamics KW - E-selectin KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20241799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Novel+Phase+I+Dose+De-escalation+Design+Trial+to+Determine+the+Biological+Modulatory+Dose+of+the+Antiangiogenic+Agent+SU5416&rft.au=Dowlati%2C+Afshin%3BRobertson%2C+Kelly%3BRadivoyevitch%2C+Tomas%3BWaas%2C+John%3BZiats%2C+Nicholas+P%3BHartman%2C+Paul%3BAbdul-Karim%2C+Fadi+W%3BWasman%2C+Jay+K%3BJesberger%2C+Jack%3BLewin%2C+Jonathan%3BMcCrae%2C+Keith%3BIvy%2C+Percy%3BRemick%2C+Scot+C&rft.aulast=Dowlati&rft.aufirst=Afshin&rft.date=2005-11-01&rft.volume=11&rft.issue=21&rft.spage=7938&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Vascular endothelial growth factor; antiangiogenic agents; Solid tumors; Magnetic resonance imaging; Fibrinogen; Biopsy; Tumors; Clinical trials; E-selectin; Pharmacodynamics; Cell adhesion molecules ER - TY - JOUR T1 - Development of Resistance to RNAi in Mammalian Cells AN - 20239992; 6663369 AB - The discovery of RNA interference (RNAi) in C. elegans and in plants has revolutionized current approaches to biology and medicine. RNAi silences genes in a sequence-specific manner through the actions of small pieces of double-stranded RNAs (siRNAs and miRNAs). RNAi has been found as a widespread natural phenomenon in eukaryotic cells and is also being used as a powerful experimental tool to explore gene function. Most importantly, it has many potential therapeutic applications. Viral gene-specific siRNAs are theoretically very promising antiviral inhibitors and have been examined in a broad range of medically important viruses. However, many RNA viruses escape RNAi-mediated suppression by counteracting the RNAi machinery through mutation of the targeted region, by encoding viral suppressors, or both. DNA viruses also counteract the RNAi machinery, preferentially using viral suppressors. Cellular factors may also contribute to RNAi resistance; ADAR1 was the first cellular factor found to be responsible for editing-mediated RNAi resistance. Because siRNAs can be used as potent small-molecule inhibitors of any cellular gene, the best way for a cell to maintain expression of essential genes for its long-term survival is to develop a program to resist the detrimental effects of RNAi. JF - Annals of the New York Academy of Sciences AU - Zheng, Zhi-Ming AU - Tang, Shuang AU - Tao, Mingfang AD - HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 105 EP - 118 PB - New York Academy of Sciences, 2 East 63rd Street New York NY 10021 USA, [mailto:publications@nyas.org], [URL:http://www.nyas.org] VL - 1058 SN - 0077-8923, 0077-8923 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Cell survival KW - Double-stranded RNA KW - Medicinal plants KW - miRNA KW - Therapeutic applications KW - RNA viruses KW - DNA viruses KW - siRNA KW - Mammalian cells KW - RNA-mediated interference KW - Mutation KW - Gene silencing KW - W 30940:Products KW - V 22340:Antiviral Agents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20239992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Development+of+Resistance+to+RNAi+in+Mammalian+Cells&rft.au=Zheng%2C+Zhi-Ming%3BTang%2C+Shuang%3BTao%2C+Mingfang&rft.aulast=Zheng&rft.aufirst=Zhi-Ming&rft.date=2005-11-01&rft.volume=1058&rft.issue=&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell survival; Mammalian cells; siRNA; Double-stranded RNA; miRNA; Medicinal plants; Therapeutic applications; RNA-mediated interference; RNA viruses; Mutation; DNA viruses; Gene silencing ER - TY - JOUR T1 - Chemoprevention with Protein Kinase A RI alpha Antisense in DMBA-Mammary Carcinogenesis AN - 20223282; 6663382 AB - Cancer is potentially preventable disease. A surprising variety of intracellular pathways can be a target for chemoprevention. Earlier it was discovered that cAMP-mediated system can play important role in prevention of DMBA-mammary carcinogenesis. There are two types of cAMP-dependent protein kinases (PKA), type I (PKA-I) and type II (PKA-II), which share a common catalytic (C) subunits, but contain distinct regulatory (R) ones, RI versus RII, respectively. Evidence suggests that increased expression of PKA-I and its regulatory subunit (RI alpha ) correlates with tumorogenesis and tumor growth. It was found that downregulation of RI alpha by 21-mer antisense oligonucleotide led to growth arrest of cancer cells. The effect of RI alpha antisense oligonucleotide correlated with a decrease in RI alpha protein and a concomitant increase in RII beta protein level. It was shown that antisense RI alpha can protect in a sequence-specific manner from 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinogenesis. At 90 days after DMBA intubation, RI alpha -antisense-treated rats exhibited significantly lower number of tumors per rat, than untreated control animals. The antisense also delayed the first tumor appearance. An increase in RI alpha and PKA-I levels in the mammary gland and liver preceded tumor production, and antisense downregulation of RI alpha restored normal levels of PKA-I and PKA-II in these tissues. Antisense RI alpha in the liver induced the phase II enzymes, glutathione S-transferase and quinone oxidoreductase, c-fos protein, and activator protein-1 (AP-1)- and cAMP response element (CRE)-directed transcription. In the mammary gland, antisense RI alpha promoted DNA repair processes. In contrast, the CRE transcription-factor decoy could not mimic these effects of antisense RI alpha . The results demonstrate that RI alpha antisense produces dual anticarcinogenic effects : (a) increasing DMBA detoxification in the liver by increasing phase II enzyme activities, increasing CRE-binding-protein phosphorylation and enhancing CRE- and AP-1 directed transcription; and (b) activating DNA repair processes in the mammary gland by downregulating of PKA-1. JF - Annals of the New York Academy of Sciences AU - Nesterova, Maria V AU - Cho-Chung, Yoon S AD - Cellular Biochemistry Section, Basic Research Laboratory, CCR, National Cancer Institute, Bethesda, Maryland 20892, USA Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 255 EP - 264 PB - New York Academy of Sciences, 2 East 63rd Street New York NY 10021 USA, [mailto:publications@nyas.org], [URL:http://www.nyas.org] VL - 1058 SN - 0077-8923, 0077-8923 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts KW - Detoxification KW - Protein kinase A KW - Mammary gland KW - Regulatory sequences KW - Activator protein 1 KW - Cyclic AMP KW - Enzymes KW - Transcription KW - Antisense DNA KW - Tumors KW - c-Fos protein KW - DNA repair KW - Intubation KW - Glutathione transferase KW - Cancer KW - Antisense oligonucleotides KW - Phosphorylation KW - Regulatory subunits KW - 9,10-Dimethyl-1,2-benzanthracene KW - Transcription factors KW - Carcinogenesis KW - Liver KW - quinone oxidoreductase KW - X 24310:Pharmaceuticals KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20223282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Chemoprevention+with+Protein+Kinase+A+RI+alpha+Antisense+in+DMBA-Mammary+Carcinogenesis&rft.au=Nesterova%2C+Maria+V%3BCho-Chung%2C+Yoon+S&rft.aulast=Nesterova&rft.aufirst=Maria&rft.date=2005-11-01&rft.volume=1058&rft.issue=&rft.spage=255&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Detoxification; Protein kinase A; Mammary gland; Regulatory sequences; Cyclic AMP; Activator protein 1; Antisense DNA; Transcription; Enzymes; c-Fos protein; Tumors; Glutathione transferase; Intubation; DNA repair; Cancer; Antisense oligonucleotides; Phosphorylation; Transcription factors; 9,10-Dimethyl-1,2-benzanthracene; Regulatory subunits; Carcinogenesis; Liver; quinone oxidoreductase ER - TY - JOUR T1 - Human beta -Defensins Suppress Human Immunodeficiency Virus Infection: Potential Role in Mucosal Protection AN - 20118744; 6504784 AB - beta -Defensins are small (3 to 5 kDa in size) secreted antimicrobial and antiviral proteins that are components of innate immunity. beta -Defensins are secreted by epithelial cells, and they are expressed at high levels in several mucosae, including the mouth, where the concentration of these proteins can reach 100 mu g/ml. Because of these properties, we wondered whether they could be part of the defenses that lower oral transmission of human immunodeficiency virus (HIV) compared to other mucosal sites. Our data show that select beta -defensins, especially human beta -defensin 2 (hBD2) and hBD3, inhibit R5 and X4 HIV infection in a dose-dependent manner at doses that are compatible with or below those measured in the oral cavity. We observed that beta -defensin treatment inhibited accumulation of early products of reverse transcription, as detected by PCR. We could not, however, detect any reproducible inhibition of env-mediated fusion, and we did not observe any modulation of HIV coreceptors following treatment with hBD1 and hBD2, in both resting and phytohemagglutinin-activated cells. Our data instead suggest that, besides a direct inactivation of HIV virions, hBD2 inhibits HIV replication in the intracellular environment. Therefore, we speculate that beta -defensins mediate a novel antiretroviral mechanism that contributes to prevention of oral HIV transmission in the oral cavity. Immunohistochemical data on hBD2 expression in oral mucosal tissue shows that hBD2 is constitutively expressed, forming a barrier layer across the epithelium in healthy subjects, while in HIV-positive subjects levels of hBD2 expression are dramatically diminished. This may predispose HIV-positive subjects to increased incidence of oral complications associated with HIV infection. JF - Journal of Virology AU - Sun, Lingling AU - Finnegan, Catherine M AU - Kish-Catalone, Tina AU - Blumenthal, Robert AU - Garzino-Demo, Paolo AU - La Terra Maggiore, Gian M AU - Berrone, Sid AU - Kleinman, Carol AU - Wu, Zhibin AU - Abdelwahab, Sayed AU - Lu, Wuyuan AU - Garzino-Demo, Alfredo AD - Division of Basic Science, Institute of Human Virology, University of Maryland Biotechnology Institute, 725 West Lombard Street, Baltimore, Maryland 21201. Center for Cancer Research Nanobiology Program, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702. Department of Maxillofacial Surgery, S. Giovanni Battista Hospital, University of Torino, Turin, Italy Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 14318 EP - 14329 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 79 IS - 22 SN - 0022-538X, 0022-538X KW - HIV KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts KW - Virions KW - Epithelial cells KW - Data processing KW - Mucosal immunity KW - Replication KW - Mucosa KW - Immunity KW - Infection KW - Oral cavity KW - Reverse transcription KW - Disease transmission KW - Antimicrobial agents KW - Defensins KW - Antiviral agents KW - Human immunodeficiency virus KW - Polymerase chain reaction KW - Epithelium KW - Mouth KW - A 01340:Antibiotics & Antimicrobials KW - V 22003:AIDS: Immunological aspects KW - F 06104:Virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20118744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Human+beta+-Defensins+Suppress+Human+Immunodeficiency+Virus+Infection%3A+Potential+Role+in+Mucosal+Protection&rft.au=Sun%2C+Lingling%3BFinnegan%2C+Catherine+M%3BKish-Catalone%2C+Tina%3BBlumenthal%2C+Robert%3BGarzino-Demo%2C+Paolo%3BLa+Terra+Maggiore%2C+Gian+M%3BBerrone%2C+Sid%3BKleinman%2C+Carol%3BWu%2C+Zhibin%3BAbdelwahab%2C+Sayed%3BLu%2C+Wuyuan%3BGarzino-Demo%2C+Alfredo&rft.aulast=Sun&rft.aufirst=Lingling&rft.date=2005-11-01&rft.volume=79&rft.issue=22&rft.spage=14318&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Virions; Epithelial cells; Data processing; Mucosal immunity; Replication; Mucosa; Immunity; Infection; Oral cavity; Antimicrobial agents; Disease transmission; Reverse transcription; Defensins; Antiviral agents; Polymerase chain reaction; Epithelium; Mouth; Human immunodeficiency virus ER - TY - JOUR T1 - Dietary Determinants of One-Carbon Metabolism and the Risk of Non-Hodgkin's Lymphoma: NCI-SEER Case-Control Study, 1998-2000 AN - 19998216; 7140970 AB - The role of dietary one-carbon determinants remains largely unexplored for non-Hodgkin's lymphoma (NHL). In a population-based case-control study of non-African-American adult (aged 20-74 years) women and men from four US Surveillance, Epidemiology, and End Results study centers (Detroit, Michigan; Iowa; Los Angeles, California; and Seattle, Washington; 1998-2000), the authors examined folate; vitamins B sub(2), B sub(6), and B sub(12); methionine; and a one-carbon antagonist, alcohol, in 425 incident NHL cases and 359 controls who completed a detailed food frequency questionnaire. Adjusted odds ratios and 95% confidence intervals were estimated by using unconditional logistic regression. Higher intake of one-carbon determinants from food was associated with a lower risk of NHL, but that for only vitamin B sub(6) (highest vs. lowest quartile: odds ratio = 0.57, 95% confidence interval: 0.34, 0.95; p trend = 0.01) and methionine (odds ratio = 0.49, 95% confidence interval: 0.31, 0.76; p trend = 0.002) reached statistical significance. Folate from food was inversely associated with diffuse subtype (odds ratio = 0.47, 95% confidence interval: 0.23, 0.94; p trend = 0.03). The authors found no association between total (food plus supplement) vitamins and NHL. Nonusers of alcohol had an elevated NHL risk compared with users, and alcohol did not modify other nutrient-NHL associations. Findings suggest that one-carbon nutrients, particularly vitamin B sub(6) and methionine, may be protective against NHL. JF - American Journal of Epidemiology AU - Lim, U AU - Schenk, M AU - Kelemen, LE AU - Davis, S AU - Cozen, W AU - Hartge, P AU - Ward, M H AU - Stolzenberg-Solomon, R AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 953 EP - 964 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 162 IS - 10 SN - 0002-9262, 0002-9262 KW - Immunology Abstracts; Risk Abstracts KW - Statistics KW - Food KW - Vitamin B6 KW - Nutrients KW - Methionine KW - Non-Hodgkin's lymphoma KW - Risk factors KW - alcohols KW - Folic acid KW - Lymphoma KW - Ethanol KW - Diets KW - USA, California, Los Angeles KW - Alcohol KW - Inventories KW - USA, Michigan, Detroit KW - Vitamin B12 KW - Epidemiology KW - USA, Iowa KW - Dietary supplements KW - INE, USA, Washington, Seattle KW - Metabolism KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19998216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Dietary+Determinants+of+One-Carbon+Metabolism+and+the+Risk+of+Non-Hodgkin%27s+Lymphoma%3A+NCI-SEER+Case-Control+Study%2C+1998-2000&rft.au=Lim%2C+U%3BSchenk%2C+M%3BKelemen%2C+LE%3BDavis%2C+S%3BCozen%2C+W%3BHartge%2C+P%3BWard%2C+M+H%3BStolzenberg-Solomon%2C+R&rft.aulast=Lim&rft.aufirst=U&rft.date=2005-11-01&rft.volume=162&rft.issue=10&rft.spage=953&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Inventories; Statistics; Food; Vitamin B6; Nutrients; Methionine; Non-Hodgkin's lymphoma; Epidemiology; Vitamin B12; Dietary supplements; Risk factors; alcohols; Folic acid; Metabolism; Ethanol; Diets; Alcohol; Lymphoma; USA, California, Los Angeles; USA, Michigan, Detroit; USA, Iowa; INE, USA, Washington, Seattle ER - TY - JOUR T1 - Molecular genetics of Staphylococcus epidermidis biofilms on indwelling medical devices AN - 19974084; 7051720 AB - Staphylococcus epidermidis is an opportunistic pathogen associated with foreign body infections and nosocomial sepsis. The pathogenicity of S. epidermidis is mostly due to its ability to colonize indwelling polymeric devices and form a thick, multilayered biofilm. Biofilm formation is a major problem in treating S. epidermidis infection as biofilms provide significant resistance to antibiotics and to components of the innate host defenses. Various cell surface associated bacterial factors play a role in adherence and accumulation of the biofilm such as the polysaccharide Intercellular adhesin and the autolysin AtlE. Furthermore, recent studies have shown that global regulators such as the agr quorum sensing system, the transcriptional regulator sarA and the alternative sigma factor sigB have an important function in the regulation of biofilm formation. Understanding the many complex mechanisms involved in biofilm formation is a key factor in the search for new anti-staphyiococcal therapeutics. JF - International Journal of Artificial Organs AU - Vadyvaloo, V AU - Otto, M AD - Rocky Mountain Laboratories, NIAID/NIH, Hamilton, MT - USA Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 1069 EP - 1078 VL - 28 IS - 11 SN - 0391-3988, 0391-3988 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Adhesins KW - Cell surface KW - quorum sensing KW - Transcription KW - Antibiotics KW - Pathogens KW - Polysaccharides KW - Infection KW - Opportunist infection KW - Autolysins KW - Sepsis KW - Pathogenicity KW - Biofilms KW - Sigma factor KW - Staphylococcus epidermidis KW - Foreign bodies KW - Hospitals KW - J 02320:Cell Biology KW - W 30920:Tissue Engineering KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19974084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Artificial+Organs&rft.atitle=Molecular+genetics+of+Staphylococcus+epidermidis+biofilms+on+indwelling+medical+devices&rft.au=Vadyvaloo%2C+V%3BOtto%2C+M&rft.aulast=Vadyvaloo&rft.aufirst=V&rft.date=2005-11-01&rft.volume=28&rft.issue=11&rft.spage=1069&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Artificial+Organs&rft.issn=03913988&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell surface; Adhesins; quorum sensing; Transcription; Antibiotics; Pathogens; Infection; Polysaccharides; Opportunist infection; Autolysins; Sepsis; Pathogenicity; Biofilms; Sigma factor; Foreign bodies; Hospitals; Staphylococcus epidermidis ER - TY - JOUR T1 - Microbial Risk Indicators of Early Childhood Caries AN - 19967071; 7143721 AB - The aim of this study was to use molecular identification methods, such as 16S RNA gene sequence and reverse-capture checkerboard hybridization, for identification of the bacteria associated with dental caries and with dental health in a subset of 204 twins aged 1.5 to 7 years old. A total of 448 plaque samples (118 collected from caries-free subjects and 330 from caries-active subjects) were used for analysis. We compared the bacteria found in biofilms of children exhibiting severe dental caries, with different degrees of lesion severity, with those found in biofilms of caries-free children. A panel of 82 bacterial species was selected, and a PCR-based reverse-capture checkerboard method was used for detection. A simple univariate test was used to determine the overabundance and underabundance of bacterial species in the diseased and in the healthy groups. Features identified with this univariate test were used to construct a probabilistic disease prediction model. Furthermore, a method for the analysis of global patterns of gene expression was performed to permit simultaneous analysis of the abundance of significant species by allowing cross-bacterial comparisons of abundance profiles between caries-active and caries-free subjects. Our results suggested that global patterns of microbial abundance in this population are very distinctive. The top bacterial species found to be overabundant in the caries-active group were Actinomyces sp. strain B19SC, Streptococcus mutans, and Lactobacillus spp., which exhibited an inverse relationship to beneficial bacterial species, such as Streptococcus parasanguinis, Abiotrophia defectiva, Streptococcus mitis, Streptococcus oralis, and Streptococcus sanguinis. JF - Journal of Clinical Microbiology AU - Corby, P M AU - Lyons-Weiler, J AU - Bretz, WA AU - Hart, T C AU - Aas, JA AU - Boumenna, T AU - Goss, J AU - Corby, AL AU - Junior, H M AU - Weyant, R J AU - Paster, B J AD - University of Pittsburgh, School of Dental Medicine, Pittsburgh, Pennsylvania. Harvard University, School of Dental Medicine, Boston, Massachusetts. University of Pittsburgh, Hillman Cancer Center, Pittsburgh, Pennsylvania. National Institute of Dental and Craniofacial Research, NIH, Division of Intramural Clinical Research, Bethesda, Maryland. Forsyth Institute, Boston, Massachusetts. University of Oslo, Institute of Oral Biology, Oslo, Norway. Twins Institute for Genetics Research, Montes Claros, Brazil. UNIMONTES, Montes Claros, Brazil Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 5753 EP - 5759 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 43 IS - 11 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Calcium & Calcified Tissue Abstracts KW - Nucleotide sequence KW - Abundance KW - Streptococcus parasanguinis KW - Children KW - Abiotrophia defectiva KW - Models KW - Gene expression KW - Dental caries KW - Lactobacillus KW - Twins KW - RNA KW - Streptococcus sanguinis KW - Plaques KW - Biofilms KW - Streptococcus mutans KW - Streptococcus mitis KW - Actinomyces KW - Streptococcus oralis KW - T 2045:Teeth KW - J 02400:Human Diseases KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19967071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Microbial+Risk+Indicators+of+Early+Childhood+Caries&rft.au=Corby%2C+P+M%3BLyons-Weiler%2C+J%3BBretz%2C+WA%3BHart%2C+T+C%3BAas%2C+JA%3BBoumenna%2C+T%3BGoss%2C+J%3BCorby%2C+AL%3BJunior%2C+H+M%3BWeyant%2C+R+J%3BPaster%2C+B+J&rft.aulast=Corby&rft.aufirst=P&rft.date=2005-11-01&rft.volume=43&rft.issue=11&rft.spage=5753&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Gene expression; Dental caries; Twins; RNA; Nucleotide sequence; Abundance; Plaques; Biofilms; Children; Models; Lactobacillus; Streptococcus sanguinis; Streptococcus parasanguinis; Streptococcus mutans; Streptococcus mitis; Abiotrophia defectiva; Actinomyces; Streptococcus oralis ER - TY - JOUR T1 - Moraxella catarrhalis Bacterium without Endotoxin, a Potential Vaccine Candidate AN - 19941422; 6503148 AB - Lipooligosaccharide (LOS) is a major surface component of Moraxella catarrhalis and a possible virulence factor in the pathogenesis of human infections caused by this organism. The presence of LOS on the bacterium is an obstacle to the development of vaccines derived from whole cells or outer membrane components of the bacterium. An lpxA gene encoding UDP-N-acetylglucosamine acyltransferase responsible for the first step of lipid A biosynthesis was identified by the construction and characterization of an isogenic M. catarrhalis lpxA mutant in strain O35E. The resulting mutant was viable despite the complete loss of LOS. The mutant strain showed significantly decreased toxicity by the Limulus amebocyte lysate assay, reduced resistance to normal human serum, reduced adherence to human epithelial cells, and enhanced clearance in lungs and nasopharynx in a mouse aerosol challenge model. Importantly, the mutant elicited high levels of antibodies with bactericidal activity and provided protection against a challenge with the wild-type strain. These data suggest that the null LOS mutant is attenuated and may be a potential vaccine candidate against M. catarrhalis. JF - Infection and Immunity AU - Peng, Daxin AU - Hong, Wenzhou AU - Choudhury, Biswa P AU - Carlson, Russell W AU - Gu, Xin-Xing AD - Vaccine Research Section, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20850. Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602 Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 7569 EP - 7577 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 73 IS - 11 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Endotoxins KW - Amebocytes KW - Epithelial cells KW - Bacteria KW - Aerosols KW - Data processing KW - virulence factors KW - Outer membranes KW - Moraxella catarrhalis KW - Animal models KW - Nasopharynx KW - Toxicity KW - Infection KW - Lipooligosaccharides KW - Antibodies KW - Limulus KW - Acyltransferase KW - Lung KW - Lipid A KW - Vaccines KW - Bactericidal activity KW - J 02834:Vaccination and immunization KW - A 01340:Antibiotics & Antimicrobials KW - G 07320:Bacterial genetics KW - F 06100:Vaccines - active immunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19941422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Moraxella+catarrhalis+Bacterium+without+Endotoxin%2C+a+Potential+Vaccine+Candidate&rft.au=Peng%2C+Daxin%3BHong%2C+Wenzhou%3BChoudhury%2C+Biswa+P%3BCarlson%2C+Russell+W%3BGu%2C+Xin-Xing&rft.aulast=Peng&rft.aufirst=Daxin&rft.date=2005-11-01&rft.volume=73&rft.issue=11&rft.spage=7569&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Amebocytes; Endotoxins; Bacteria; Epithelial cells; Aerosols; Data processing; virulence factors; Outer membranes; Animal models; Nasopharynx; Toxicity; Infection; Lipooligosaccharides; Antibodies; Lung; Acyltransferase; Lipid A; Vaccines; Bactericidal activity; Limulus; Moraxella catarrhalis ER - TY - JOUR T1 - Detection of Lymph Node Involvement in Hematologic Malignancies Using Micromagnetic Resonance Lymphangiography with a Gadolinum-Labeled Dendrimer Nanoparticle AN - 19936045; 7076548 AB - Animal models of lymphoma should reflect their counterparts in humans; however, it can be difficult to ascertain whether an induced disease is intralymphatic or extralymphatic based on direct visualization. Current imaging methods are insufficient for identifying lymphatic and intralymphatic involvement. To differentiate intralymphatic from extralymphatic involvement, we have developed a magnetic resonance imaging-based lymphangiography method and tested it on two animal models of lymphoma. A gadolinium (Gd)-labeled dendrimer nanoparticle (generation-6; similar to 220 kDa/ similar to 10 nm) was injected interstitially into mice bearing hematologic malignancies to perform dynamic micromagnetic resonance lymphangiography (micro-MRL). Both a standard T1-weighted 3D fast spoiled gradient echo and a T2/Tl-weighted 3D fast imaging employing steady-state acquisition (3D-FIESTA-C) were compared in an imaging study to differentiate intralymphatic from extralymphatic involvement of tumors. The lymphatics and lymph nodes were visualized with both methods in all cases. In addition, 3D-FIESTA-C depicted both the lymphatic system and the extralymphatic tumor. In an animal model, 3D-FIESTA-C demonstrated that the bulk of the tumor thought to be intralymphatic was actually extralymphatic. In conclusion, micro-MRL, using Gd-labeled dendrimer nanoparticles with the combined method, can define both the normal and abnormal lymphatics and can distinguish intralymphatic from extralymphatic diseases in mouse models of malignant lymphoma. JF - Neoplasia AU - Kobayashi, H AU - Kawamoto, S AU - Brechbiel, M W AU - Bernardo, M AU - Sato, N AU - Waldmann, T A AU - Tagaya, Y AU - Choyke, P L AD - Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 984 EP - 991 VL - 7 IS - 11 SN - 1522-8002, 1522-8002 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Malignancy KW - Gadolinium KW - Magnetic resonance imaging KW - Animal models KW - Tumors KW - imaging KW - Lymphoma KW - nanoparticles KW - Lymph nodes KW - Lymphatic system KW - Lymphangiography KW - W 30905:Medical Applications KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19936045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neoplasia&rft.atitle=Detection+of+Lymph+Node+Involvement+in+Hematologic+Malignancies+Using+Micromagnetic+Resonance+Lymphangiography+with+a+Gadolinum-Labeled+Dendrimer+Nanoparticle&rft.au=Kobayashi%2C+H%3BKawamoto%2C+S%3BBrechbiel%2C+M+W%3BBernardo%2C+M%3BSato%2C+N%3BWaldmann%2C+T+A%3BTagaya%2C+Y%3BChoyke%2C+P+L&rft.aulast=Kobayashi&rft.aufirst=H&rft.date=2005-11-01&rft.volume=7&rft.issue=11&rft.spage=984&rft.isbn=&rft.btitle=&rft.title=Neoplasia&rft.issn=15228002&rft_id=info:doi/10.1593%2Fneo.05454 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Malignancy; Magnetic resonance imaging; Gadolinium; Animal models; Tumors; nanoparticles; Lymphoma; imaging; Lymphatic system; Lymph nodes; Lymphangiography DO - http://dx.doi.org/10.1593/neo.05454 ER - TY - JOUR T1 - Modeling genome evolution with a diffusion approximation of a birth-and-death process AN - 19883459; 7873098 AB - Motivation: In our previous studies, we developed discrete-space birth, death and innovation models (BDIMs) of genome evolution. These models explain the origin of the characteristic Pareto distribution of paralogous gene family sizes in genomes, and model parameters that provide for the evolution of these distributions within a realistic time frame have been identified. However, extracting the temporal dynamics of genome evolution from discrete-space BDIM was not technically feasible. We were interested in obtaining dynamic portraits of the genome evolution process by developing a diffusion approximation of BDIM. Results: The diffusion version of BDIM belongs to a class of continuous-state models whose dynamics is described by the Fokker-Plank equation and the stationary solution could be any specified Pareto function. The diffusion models have time-dependent solutions of a special kind, namely, generalized self-similar solutions, which describe the transition from one stationary distribution of the system to another; this provides for the possibility of examining the temporal dynamics of genome evolution. Analysis of the generalized self-similar solutions of the diffusion BDIM reveals a biphasic curve of genome growth in which the initial, relatively short, self-accelerating phase is followed by a prolonged phase of slow deceleration. This evolutionary dynamics was observed both when genome growth started from zero and proceeded via innovation (a potential model of primordial evolution), and when evolution proceeded from one stationary state to another. In biological terms, this regime of evolution can be tentatively interpreted as a punctuated-equilibrium-like phenomenon whereby evolutionary transitions are accompanied by rapid gene amplification and innovation, followed by slow relaxation to a new stationary state. JF - Bioinformatics AU - Karev, Georgy P AU - Berezovskaya, Faina S AU - Koonin, Eugene V Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 1 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 21 IS - S3 SN - 1367-4803, 1367-4803 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Genomes KW - Birth KW - Mathematical models KW - Gene amplification KW - Diffusion KW - Bioinformatics KW - Gene families KW - Models KW - G 07740:Evolution KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19883459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Modeling+genome+evolution+with+a+diffusion+approximation+of+a+birth-and-death+process&rft.au=Karev%2C+Georgy+P%3BBerezovskaya%2C+Faina+S%3BKoonin%2C+Eugene+V&rft.aulast=Karev&rft.aufirst=Georgy&rft.date=2005-11-01&rft.volume=21&rft.issue=S3&rft.spage=iii12&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Birth; Genomes; Mathematical models; Gene amplification; Diffusion; Bioinformatics; Gene families; Models ER - TY - JOUR T1 - Pooled ORF Expression Technology (POET): Using Proteomics to Screen Pools of Open Reading Frames for Protein Expression AN - 19770431; 7144614 AB - We have developed a pooled ORF expression technology, POET, that uses recombinational cloning and proteomic methods (two-dimensional gel electrophoresis and mass spectrometry) to identify ORFs that when expressed are likely to yield high levels of soluble, purified protein. Because the method works on pools of ORFs, the procedures needed to subclone, express, purify, and assay protein expression for hundreds of clones are greatly simplified. Small scale expression and purification of 12 positive clones identified by POET from a pool of 688 Caenorhabditis elegans ORFs expressed in Escherichia coli yielded on average 6 times as much protein as 12 negative clones. Larger scale expression and purification of six of the positive clones yielded 47-374 mg of purified protein/liter. Using POET, pools of ORFs can be constructed, and the pools of the resulting proteins can be analyzed and manipulated to rapidly acquire information about the attributes of hundreds of proteins simultaneously. JF - Molecular and Cellular Proteomics AU - Gillette, William K AU - Esposito, Dominic AU - Frank, Peter H AU - Zhou, Ming AU - Yu, Li-Rong AU - Jozwik, Catherine AU - Zhang, Xiuying AU - McGowan, Brighid AU - Jacobowitz, David M AU - Pollard, Harvey B AU - Hao, Tong AU - Hill, David E AU - Vidal, Marc AU - Conrads, Thomas P AU - Veenstra, Timothy D AU - Hartley, James L AD - Protein Expression Laboratory and Laboratory of Proteomics and Analytical Technologies, Research Technology Program, SAIC-Frederick, Inc./NCI, National Institutes of Health, Frederick, Maryland 21702, Department of Anatomy, Physiology, and Genetics, Uniformed Services University, Bethesda, Maryland 20814, Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, and Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20892 Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 1647 EP - 1652 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.asbmb.org/] VL - 4 IS - 11 SN - 1535-9476, 1535-9476 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Caenorhabditis elegans KW - Escherichia coli KW - proteomics KW - protein purification KW - Open reading frames KW - Gel electrophoresis KW - Mass spectroscopy KW - J 02310:Genetics & Taxonomy KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19770431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Proteomics&rft.atitle=Pooled+ORF+Expression+Technology+%28POET%29%3A+Using+Proteomics+to+Screen+Pools+of+Open+Reading+Frames+for+Protein+Expression&rft.au=Gillette%2C+William+K%3BEsposito%2C+Dominic%3BFrank%2C+Peter+H%3BZhou%2C+Ming%3BYu%2C+Li-Rong%3BJozwik%2C+Catherine%3BZhang%2C+Xiuying%3BMcGowan%2C+Brighid%3BJacobowitz%2C+David+M%3BPollard%2C+Harvey+B%3BHao%2C+Tong%3BHill%2C+David+E%3BVidal%2C+Marc%3BConrads%2C+Thomas+P%3BVeenstra%2C+Timothy+D%3BHartley%2C+James+L&rft.aulast=Gillette&rft.aufirst=William&rft.date=2005-11-01&rft.volume=4&rft.issue=11&rft.spage=1647&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Proteomics&rft.issn=15359476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - protein purification; proteomics; Mass spectroscopy; Gel electrophoresis; Open reading frames; Caenorhabditis elegans; Escherichia coli ER - TY - JOUR T1 - The observed effects of teenage passengers on the risky driving behavior of teenage drivers AN - 19719254; 7511129 AB - The association between teenage passengers and crash risks among young drivers may be due to risky driving behavior. We investigated the effect on two measures of risky driving in the presence of young male and female passengers. Vehicles exiting from parking lots at 10 high schools were observed and the occupants were identified by gender and age (teen or adult). At a nearby site, the speed and headway of passing traffic were recorded using video and LIDAR technology. Teenage drivers drove faster than the general traffic and allowed shorter headways, particularly in the presence of a male teenage passenger. Both male and female teenage drivers allowed shorter headways (relative to no passenger or a female passenger) in the presence of a male teenage passenger, while the presence of a female teenage passenger resulted in longer headways for male teenage drivers. Overall, the observed rate of high risk driving (defined as speed >=15mph or more above the posted speed limit and/or headway of <=1.0s) for the teen male driver/male passenger condition was about double that of general traffic. In conclusion, the presence of male teenage passengers was associated with risky driving behavior among teenage drivers. JF - Accident Analysis & Prevention AU - Simons-Morton, Bruce AU - Lerner, Neil AU - Singer, Jeremiah AD - Prevention Research Branch, Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, 6100 Executive Blvd RM#7B13M, Bethesda, MD 20892-7510, USA, Mortonb@mail.nih.gov Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 973 EP - 982 PB - Elsevier Science Ltd., Pergamon, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 37 IS - 6 SN - 0001-4575, 0001-4575 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Motor vehicles KW - Adolescents KW - Risk taking KW - Social influences KW - Speeding KW - Passengers KW - Accidents KW - Behavior KW - driving ability KW - Gender KW - prevention KW - Traffic safety KW - decision making KW - H 2000:Transportation KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19719254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Accident+Analysis+%26+Prevention&rft.atitle=The+observed+effects+of+teenage+passengers+on+the+risky+driving+behavior+of+teenage+drivers&rft.au=Simons-Morton%2C+Bruce%3BLerner%2C+Neil%3BSinger%2C+Jeremiah&rft.aulast=Simons-Morton&rft.aufirst=Bruce&rft.date=2005-11-01&rft.volume=37&rft.issue=6&rft.spage=973&rft.isbn=&rft.btitle=&rft.title=Accident+Analysis+%26+Prevention&rft.issn=00014575&rft_id=info:doi/10.1016%2Fj.aap.2005.04.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Accidents; Behavior; driving ability; Gender; prevention; decision making; Traffic safety; Adolescents DO - http://dx.doi.org/10.1016/j.aap.2005.04.014 ER - TY - JOUR T1 - Multicontrast delayed enhancement provides improved contrast between myocardial infarction and blood pool AN - 19687218; 7456794 AB - To develop and test a delayed-enhancement imaging method for improving the contrast between myocardial infarction (MI) and blood pool. The T sub(2) of blood is significantly longer than that of acute or chronic MI. The proposed multicontrast delayed-enhancement (MCODE) imaging method produces a series of images with both T sub(1) and T sub(2) weightings, which provides both excellent contrast between normal and infarcted myocardium, and between blood and MI. The subendocardial border between MI and blood pool was easily discriminated in the T sub(2)-weighted image. The measured MI-to-blood contrast-to-noise ratio (CNR) was better in the T sub(2)-weighted image than in the T sub(1)-weighted image (22.5 +/- 8.7 vs. 2.9 +/- 3.1, mean +/- SD, N = 11, P < 0.001, for TrueFISP, and 19.4 +/- 10.8 vs. 3.9 +/- 2.3, N = 11, P < 0.001, for TurboFLASH). The MCODE method provides a significant improvement in the ability to easily discriminate subendocardial MI by providing a T sub(2)-weighted image with high contrast between blood and MI. MCODE should improve both the detection and accurate sizing of MI. J. Magn. Reson. Imaging 2005. Published by Wiley-Liss, Inc. JF - Journal of Magnetic Resonance Imaging AU - Kellman, Peter AU - Chung, Yiu-Cho AU - Simonetti, Orlando P AU - McVeigh, Elliot R AU - Arai, Andrew E AD - Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland, USA, kellman@nih.gov Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 605 EP - 613 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 22 IS - 5 SN - 1053-1807, 1053-1807 KW - Biotechnology and Bioengineering Abstracts KW - Blood KW - Magnetic resonance imaging KW - Myocardial infarction KW - Myocardium KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19687218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Magnetic+Resonance+Imaging&rft.atitle=Multicontrast+delayed+enhancement+provides+improved+contrast+between+myocardial+infarction+and+blood+pool&rft.au=Kellman%2C+Peter%3BChung%2C+Yiu-Cho%3BSimonetti%2C+Orlando+P%3BMcVeigh%2C+Elliot+R%3BArai%2C+Andrew+E&rft.aulast=Kellman&rft.aufirst=Peter&rft.date=2005-11-01&rft.volume=22&rft.issue=5&rft.spage=605&rft.isbn=&rft.btitle=&rft.title=Journal+of+Magnetic+Resonance+Imaging&rft.issn=10531807&rft_id=info:doi/10.1002%2Fjmri.20426 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Blood; Myocardial infarction; Magnetic resonance imaging; Myocardium DO - http://dx.doi.org/10.1002/jmri.20426 ER - TY - JOUR T1 - The Progress and Promise of Molecular Imaging Probes in Oncologic Drug Development AN - 19464576; 7142108 AB - As addressed by the recent Food and Drug Administration Critical Path Initiative, tools are urgently needed to increase the speed, efficiency, and cost-effectiveness of drug development for cancer and other diseases. Molecular imaging probes developed based on recent scientific advances have great potential as oncologic drug development tools. Basic science studies using molecular imaging probes can help to identify and characterize disease-specific targets for oncologic drug therapy. Imaging end points, based on these disease-specific biomarkers, hold great promise to better define, stratify, and enrich study groups and to provide direct biological measures of response. Imaging-based biomarkers also have promise for speeding drug evaluation by supplementing or replacing preclinical and clinical pharmacokinetic and pharmacodynamic evaluations, including target interaction and modulation. Such analyses may be particularly valuable in early comparative studies among candidates designed to interact with the same molecular target. Finally, as response biomarkers, imaging end points that characterize tumor vitality, growth, or apoptosis can also serve as early surrogates of therapy success. This article outlines the scientific basis of oncology imaging probes and presents examples of probes that could facilitate progress. The current regulatory opportunities for new and existing probe development and testing are also reviewed, with a focus on recent Food and Drug Administration guidance to facilitate early clinical development of promising probes. JF - Clinical Cancer Research AU - Kelloff, Gary J AU - Krohn, Kenneth A AU - Larson, Steven M AU - Weissleder, Ralph AU - Mankoff, David A AU - Hoffman, John M AU - Link, Jeanne M AU - Guyton, Kathryn Z AU - Eckelman, William C AU - Scher, Howard I AU - O'Shaughnessy, Joyce AU - Cheson, Bruce D AU - Sigman, Caroline C AU - Tatum, James L AU - Mills, George Q AU - Sullivan, Daniel C AU - Woodcock, Janet AD - Authors' Affiliations: Cancer Imaging Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 7967 EP - 7985 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 11 IS - 22 SN - 1078-0432, 1078-0432 KW - Biotechnology and Bioengineering Abstracts KW - Apoptosis KW - Reviews KW - Oncology KW - Drug development KW - Tumors KW - biomarkers KW - imaging KW - Pharmacodynamics KW - Pharmacokinetics KW - Cancer KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19464576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=The+Progress+and+Promise+of+Molecular+Imaging+Probes+in+Oncologic+Drug+Development&rft.au=Kelloff%2C+Gary+J%3BKrohn%2C+Kenneth+A%3BLarson%2C+Steven+M%3BWeissleder%2C+Ralph%3BMankoff%2C+David+A%3BHoffman%2C+John+M%3BLink%2C+Jeanne+M%3BGuyton%2C+Kathryn+Z%3BEckelman%2C+William+C%3BScher%2C+Howard+I%3BO%27Shaughnessy%2C+Joyce%3BCheson%2C+Bruce+D%3BSigman%2C+Caroline+C%3BTatum%2C+James+L%3BMills%2C+George+Q%3BSullivan%2C+Daniel+C%3BWoodcock%2C+Janet&rft.aulast=Kelloff&rft.aufirst=Gary&rft.date=2005-11-01&rft.volume=11&rft.issue=22&rft.spage=7967&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - imaging; Drug development; biomarkers; Reviews; Cancer; Tumors; Pharmacokinetics; Pharmacodynamics; Oncology; Apoptosis ER - TY - JOUR T1 - Impact of Hysterectomy on Endometrial Carcinoma Rates in the United States AN - 19461278; 7144218 AB - In the United States, endometrial carcinoma incidence rates, uncorrected for hysterectomy prevalence, are higher among white women than black women. We estimated corrected endometrial carcinoma rates by racial/ethnic groups and age (30-74 years) for 1992-2000 using data from the Surveillance, Epidemiology, and End Results program and the Behavioral Risk Factor Surveillance Survey. Hysterectomy prevalence was higher among black women than among Hispanic and white non-Hispanic women. Correcting for hysterectomy prevalence increased age-adjusted endometrial carcinoma rates per 10 super(5) woman-years from 29.2 to 48.7 (66.8% increase) overall, from 14.6 to 28.5 (95.3% increase) in blacks, from 18.8 to 29.6 (57.6% increase) in Hispanics, and from 33.2 to 54.9 (65.1%) in white non-Hispanics. This correction reduced the rate ratio for white non-Hispanics compared with blacks from 2.27 to 1.93. Among blacks but not Hispanics or white non-Hispanics, the endometrial carcinoma risk factors of obesity and diabetes were more prevalent among hysterectomized than nonhysterectomized women. Failure to correct for hysterectomy prevalence may lead to underestimates of endometrial carcinoma risk, especially among blacks.The high prevalence of hysterectomy among blacks with strong endometrial cancer risk factors may partly account for lower cancer rates in this group. JF - Journal of the National Cancer Institute AU - Sherman, Mark E AU - Carreon, Joseph D AU - Lacey, James VJr AU - Devesa, Susan S AD - Hormonal and Reproductive Epidemiology (MES, JDC, JVL) and Biostatistics (SSD) Branches, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 1700 EP - 1702 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 97 IS - 22 SN - 0027-8874, 0027-8874 KW - hysterectomy KW - Risk Abstracts KW - USA KW - obesity KW - Females KW - Cancer KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19461278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Impact+of+Hysterectomy+on+Endometrial+Carcinoma+Rates+in+the+United+States&rft.au=Sherman%2C+Mark+E%3BCarreon%2C+Joseph+D%3BLacey%2C+James+VJr%3BDevesa%2C+Susan+S&rft.aulast=Sherman&rft.aufirst=Mark&rft.date=2005-11-01&rft.volume=97&rft.issue=22&rft.spage=1700&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - obesity; Females; Ethnic groups; Cancer; USA ER - TY - JOUR T1 - Activity of anchored human matrix metalloproteinase-1 catalytic domain on Au (111) surfaces monitored by ESI-MS AN - 19422977; 6673152 AB - Matrix metalloproteinases (MMPs) are a family of Zn-dependent endo- peptidases known for their ability to cleave several components of the extracellular matrix, but which can also cleave many non-matrix proteins. There are many evidences that MMPs are involved in physiological and pathological processes, and a huge effort has been put in the development of possible inhibitors that could reduce the activity of MMPs, as it is clear that the ability to monitor and control such activity plays a pivotal role in the search for potential drugs aimed at finding a cure for several diseases such as pulmonary emphysema, rheumatoid arthritis, fibrotic disorders and cancer. JF - Journal of Mass Spectrometry AU - Grasso, Giuseppe AU - D'Agata, Roberta AU - Rizzarelli, Enrico AU - Spoto, Giuseppe AU - D'Andrea, Luca AU - Pedone, Carlo AU - Picardi, Andrea AU - Romanelli, Alessandra AU - Fragai, Marco AU - Yeo, Kwon Joo AD - Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici, Via C. Ulpiani 27, 70126, Bari, Italy, gspoto@dipchi.unict.it Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 1565 EP - 1571 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 40 IS - 12 SN - 1076-5174, 1076-5174 KW - Biotechnology and Bioengineering Abstracts KW - Emphysema KW - Rheumatoid arthritis KW - Extracellular matrix KW - Lung diseases KW - Matrix metalloproteinase KW - Drug development KW - peptidase KW - Cancer KW - Mass spectroscopy KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19422977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Mass+Spectrometry&rft.atitle=Activity+of+anchored+human+matrix+metalloproteinase-1+catalytic+domain+on+Au+%28111%29+surfaces+monitored+by+ESI-MS&rft.au=Grasso%2C+Giuseppe%3BD%27Agata%2C+Roberta%3BRizzarelli%2C+Enrico%3BSpoto%2C+Giuseppe%3BD%27Andrea%2C+Luca%3BPedone%2C+Carlo%3BPicardi%2C+Andrea%3BRomanelli%2C+Alessandra%3BFragai%2C+Marco%3BYeo%2C+Kwon+Joo&rft.aulast=Grasso&rft.aufirst=Giuseppe&rft.date=2005-11-01&rft.volume=40&rft.issue=12&rft.spage=1565&rft.isbn=&rft.btitle=&rft.title=Journal+of+Mass+Spectrometry&rft.issn=10765174&rft_id=info:doi/10.1002%2Fjms.929 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Drug development; peptidase; Mass spectroscopy; Emphysema; Cancer; Lung diseases; Extracellular matrix; Matrix metalloproteinase; Rheumatoid arthritis DO - http://dx.doi.org/10.1002/jms.929 ER - TY - JOUR T1 - Analysis of mass spectral serum profiles for biomarker selection AN - 19419657; 6509140 AB - MOTIVATION: Mass spectrometric profiles of peptides and proteins obtained by current technologies are characterized by complex spectra, high dimensionality and substantial noise. These characteristics generate challenges in the discovery of proteins and protein-profiles that distinguish disease states, e.g. cancer patients from healthy individuals. We present low-level methods for the processing of mass spectral data and a machine learning method that combines support vector machines, with particle swarm optimization for biomarker selection. RESULTS: The proposed method identified mass points that achieved high prediction accuracy in distinguishing liver cancer patients from healthy individuals in SELDI-QqTOF profiles of serum. AVAILABILITY: MATLAB scripts to implement the methods described in this paper are available from the HWR's lab website http://lombardi.georgetown.edu/labpage CONTACT: hwreorgetown.edu JF - Bioinformatics AU - Ressom, Habtom W AU - Varghese, Rency S AU - Abdel-Hamid, Mohamed AU - Eissa, Sohair Abdel-Latif AU - Saha, Daniel AU - Goldman, Lenka AU - Petricoin, Emanuel F AU - Conrads, Thomas P AU - Veenstra, Timothy D AU - Loffredo, Christopher A AU - Goldman, Radoslav AD - Lombardi Comprehensive Cancer Center, Georgetown University Washington, DC, USA. Viral Hepatitis Research Laboratory, NHTMRI Cairo, Egypt. Natinal Cancer Institute Cairo, Egypt. Clinical Proteomics Program, NCI/FDA, Center for Biologics Evaluation, FDA USA. SAIC-Frederick and Biomedical Proteomics Program, NCI Frederick, MD, USA Y1 - 2005/11/01/ PY - 2005 DA - 2005 Nov 01 SP - 4039 EP - 4045 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 21 IS - 21 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Swarms KW - Bioinformatics KW - Learning algorithms KW - biomarkers KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19419657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Analysis+of+mass+spectral+serum+profiles+for+biomarker+selection&rft.au=Ressom%2C+Habtom+W%3BVarghese%2C+Rency+S%3BAbdel-Hamid%2C+Mohamed%3BEissa%2C+Sohair+Abdel-Latif%3BSaha%2C+Daniel%3BGoldman%2C+Lenka%3BPetricoin%2C+Emanuel+F%3BConrads%2C+Thomas+P%3BVeenstra%2C+Timothy+D%3BLoffredo%2C+Christopher+A%3BGoldman%2C+Radoslav&rft.aulast=Ressom&rft.aufirst=Habtom&rft.date=2005-11-01&rft.volume=21&rft.issue=21&rft.spage=4039&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - biomarkers; Learning algorithms; Bioinformatics; Swarms ER - TY - JOUR T1 - A Family Portrait of the RIO Kinases AN - 19376981; 7143124 AB - The RIO family of atypical serine protein kinases has been first characterized only recently. It consists of enzymes that contain a unique domain with a characteristic kinase sequence motif and usually some additional domains. At least two RIO proteins, Rio1 and Rio2, are present in organisms varying from Archaea to humans, with a third Rio3 subfamily present only in multicellular eukaryotes. Yeast Rio1 and Rio2 proteins have been implicated in the processing of 20 S pre-rRNA and are necessary for survival of the cells. Crystal structures of Archaeoglobus fulgidus Rio1 and Rio2 have shown that whereas the overall fold of these enzymes resembles typical protein kinases, some of the structural domains, particularly those involved in peptide substrate binding, are not present. The mode of binding of nucleotides also differs from that found in typical protein kinases. Although it has been shown that both Rio1 and Rio2 have the enzymatic activity of kinases and are capable of autophosphorylation, the biological substrates of RIO proteins and their full biological role still remain to be discovered. JF - Journal of Biological Chemistry AU - LaRonde-LeBlanc, Nicole AU - Wlodawer, Alexander AD - Protein Structure Section, Macromolecular Crystallography Laboratory, NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702-1201 Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 37297 EP - 37300 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 280 IS - 45 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology KW - Cell survival KW - Archaea KW - Archaeoglobus fulgidus KW - Crystal structure KW - Protein kinase KW - Enzymes KW - Enzymatic activity KW - Serine KW - Nucleotides KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19376981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=A+Family+Portrait+of+the+RIO+Kinases&rft.au=LaRonde-LeBlanc%2C+Nicole%3BWlodawer%2C+Alexander&rft.aulast=LaRonde-LeBlanc&rft.aufirst=Nicole&rft.date=2005-11-01&rft.volume=280&rft.issue=45&rft.spage=37297&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cell survival; Crystal structure; Enzymes; Protein kinase; Enzymatic activity; Nucleotides; Serine; Archaea; Archaeoglobus fulgidus ER - TY - JOUR T1 - Toll-like Receptor 4 Signaling Regulates Cytosolic Phospholipase A sub(2) Activation and Lipid Generation in Lipopolysaccharide-stimulated Macrophages AN - 19375330; 7143319 AB - Inflammatory lipid mediators such as prostaglandins and leukotrienes play crucial roles in the pathogenesis of bacterial lipopolysaccharide (LPS)-induced inflammation. Cytosolic phospholipase A sub(2) (cPLA sub(2)) is a key enzyme in the generation of pro-inflammatory lipid mediators. Here, we found that Toll-like receptor 4 (TLR4) is essential for LPS-induced cPLA sub(2) activation and lipid release. Inhibition of TLR4 protein expression by TLR4 small interfering RNA or neutralization of TLR4 by the specific antibody against TLR4/MD2 blocked cPLA sub(2) phosphorylation and cPLA sub(2)-hydrolyzed arachidonic acid release. Furthermore, activation of the TLR4 signaling pathway by LPS regulated cPLA sub(2) activation and lipid release. cPLA sub(2) phosphorylation and cPLA sub(2)-hydrolyzed lipid release were significantly impaired when TLR4 adaptor protein, either MyD88 or TRIF, was knocked down in LPS-stimulated macrophages. Similarly, LPS-induced arachidonate release was inhibited in cells transfected with a dominant-negative MyD88 or TRIF construct. Subsequently, cPLA sub(2) activation could be suppressed by inhibition of the TLR4 adaptor protein-directed p38 and ERK MAPK pathways. These findings suggest that, in LPS-induced inflammation, the TLR4-mediated MyD88- and TRIF-dependent MAPK pathways result in cPLA sub(2) activation and production of pro-inflammatory lipid mediators. JF - Journal of Biological Chemistry AU - Qi, Hai-Yan AU - Shelhamer, James H AD - Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 38969 EP - 38975 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 280 IS - 47 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Leukotrienes KW - MAP kinase KW - MyD88 protein KW - Phospholipase A2 KW - Lipids KW - Prostaglandins KW - Enzymes KW - Arachidonic acid KW - Inflammation KW - Cell activation KW - Extracellular signal-regulated kinase KW - adaptor proteins KW - Antibodies KW - Phosphorylation KW - siRNA KW - Lipopolysaccharides KW - TLR4 protein KW - Toll-like receptors KW - Signal transduction KW - J 02350:Immunology KW - F 06965:Immune Cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19375330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Toll-like+Receptor+4+Signaling+Regulates+Cytosolic+Phospholipase+A+sub%282%29+Activation+and+Lipid+Generation+in+Lipopolysaccharide-stimulated+Macrophages&rft.au=Qi%2C+Hai-Yan%3BShelhamer%2C+James+H&rft.aulast=Qi&rft.aufirst=Hai-Yan&rft.date=2005-11-01&rft.volume=280&rft.issue=47&rft.spage=38969&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Leukotrienes; Macrophages; MAP kinase; Phospholipase A2; MyD88 protein; Lipids; Prostaglandins; Arachidonic acid; Enzymes; Cell activation; Inflammation; Extracellular signal-regulated kinase; Antibodies; adaptor proteins; siRNA; Phosphorylation; Lipopolysaccharides; TLR4 protein; Toll-like receptors; Signal transduction ER - TY - JOUR T1 - Epidemiology of Pediatric Tuberculosis Using Traditional and Molecular Techniques: Houston, Texas AN - 19288808; 6505413 AB - OBJECTIVE: To investigate the transmission dynamics of pediatric tuberculosis (TB) by analyzing the clinical characteristics with the molecular profiles of Mycobacterium tuberculosis isolates during a 5-year period. METHODS: A retrospective review of a prospective population-based active surveillance and molecular epidemiology project was conducted in private and public pediatric clinics within Houston and Harris County, Texas. The study population consisted of patients who had pediatric TB diagnosed from October 1, 1995, through September 30, 2000. Cases and potential source cases (PSC) were interviewed using a standardized questionnaire. Available Mycobacterium tuberculosis isolates from cases and PSCs were characterized and compared by IS6110 restriction fragment length polymorphism, spoligotyping, and genetic group assignment. Clinical characteristics were described, and molecular characterizations were compared. Data were analyzed by using EpiInfo 6.02b and SAS 8.2. RESULTS: A total of 220 (92%) of 238 pediatric TB cases were included. Epidemiologic and clinical findings were consistent with previous studies. Molecular profiles from 3 cases did not match the profile of PSC. Four previously unknown PSCs were identified using molecular techniques. Fifty-one (71.8%) of 71 isolates matched at least 1 other Houston Tuberculosis Initiative TB database isolate and were grouped into 33 molecular clusters. Cases were more likely to be clustered when the patients were younger than 5 years, identified a source case, or were US born. CONCLUSIONS: Traditional contact tracing may not always be accurate, and molecular characterization can lead to identification of previously unrecognized source cases. Recent transmission plays a significant role in the transmission of TB to children as evident by the high degree of clustering found in our study population. JF - Pediatrics AU - Wootton, Susan H AU - Gonzalez, Blanca E AU - Pawlak, Rebecca AU - Teeter, Larry D AU - Smith, Kim Connelly AU - Musser, James M AU - Starke, Jeffrey R AU - Graviss, Edward A AD - Department of Pediatrics, Infectious Disease Section, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas. Pathology. Medicine, Baylor College of Medicine, Houston, Texas. Department of Pediatrics, University of Texas-Houston Medical School, Houston, Texas. Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 1141 EP - 1147 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 116 IS - 5 SN - 0031-4005, 0031-4005 KW - Microbiology Abstracts B: Bacteriology KW - Inventories KW - Data processing KW - Pediatrics KW - Restriction fragment length polymorphism KW - Population studies KW - Contact tracing KW - Children KW - spoligotyping KW - Disease transmission KW - Databases KW - Epidemiology KW - Tuberculosis KW - Mycobacterium tuberculosis KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19288808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Epidemiology+of+Pediatric+Tuberculosis+Using+Traditional+and+Molecular+Techniques%3A+Houston%2C+Texas&rft.au=Wootton%2C+Susan+H%3BGonzalez%2C+Blanca+E%3BPawlak%2C+Rebecca%3BTeeter%2C+Larry+D%3BSmith%2C+Kim+Connelly%3BMusser%2C+James+M%3BStarke%2C+Jeffrey+R%3BGraviss%2C+Edward+A&rft.aulast=Wootton&rft.aufirst=Susan&rft.date=2005-11-01&rft.volume=116&rft.issue=5&rft.spage=1141&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Databases; Inventories; Data processing; Epidemiology; Pediatrics; Restriction fragment length polymorphism; Population studies; Tuberculosis; Children; Contact tracing; Disease transmission; spoligotyping; Mycobacterium tuberculosis ER - TY - JOUR T1 - Disposition of Cocaine and Its Metabolites in Human Sweat after Controlled Cocaine Administration AN - 17663267; 6502872 AB - BACKGROUND: Sweat testing is a noninvasive technique for monitoring drug exposure in treatment, criminal justice, and employment settings. METHODS: We evaluated cocaine excretion in 9 participants' sweat after they received 3 low doses (75 mg/70 kg) of cocaine HCl subcutaneously within 1 week and, 3 weeks later, 3 high doses (150 mg/70 kg). Six additional participants completed portions of the study. PharmChek registered sweat patches (n = 1390) were collected throughout a 3-week washout period, reflecting previously self-administered drugs, and during and after controlled dosing. RESULTS: Cocaine was the primary analyte detected with 24% of patches positive at the gas chromatography-mass spectrometry limit of quantification of 2.5 ng/patch and 7% of patches at the proposed Substance Abuse and Mental Health Services Administration cutoff of 25 ng/patch. Ecgonine methyl ester (EME) was detected more often and at generally higher concentrations than benzoylecgonine. In patches containing both metabolites, there was no statistically significant difference in the benzoylecgonine/EME ratio based on length of patch wear. During washout, 2 participants' weekly patches tested positive ( greater than or equal to 25 ng/patch) during the first week; one remained positive during week 2; and none were positive during week 3. Cocaine and EME were detectable within 2 h; benzoylecgonine was not detected until 4-8 h after low doses and slightly sooner after high doses. The majority of drug was excreted within 24 h. Over 70% of weekly patches worn during low doses were positive for cocaine ( greater than or equal to 25 ng/patch), increasing to 100% during high doses. CONCLUSION: Sweat testing is an effective and reliable method of monitoring cocaine exposure. JF - Clinical Chemistry AU - Kacinko, Sherri L AU - Barnes, Allan J AU - Schwilke, Eugene W AU - Cone, Edward J AU - Moolchan, Eric T AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD. Johns Hopkins School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 2085 EP - 2094 PB - American Association for Clinical Chemistry, Inc. VL - 51 IS - 11 SN - 0009-9147, 0009-9147 KW - Toxicology Abstracts KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17663267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Chemistry&rft.atitle=Disposition+of+Cocaine+and+Its+Metabolites+in+Human+Sweat+after+Controlled+Cocaine+Administration&rft.au=Kacinko%2C+Sherri+L%3BBarnes%2C+Allan+J%3BSchwilke%2C+Eugene+W%3BCone%2C+Edward+J%3BMoolchan%2C+Eric+T%3BHuestis%2C+Marilyn+A&rft.aulast=Kacinko&rft.aufirst=Sherri&rft.date=2005-11-01&rft.volume=51&rft.issue=11&rft.spage=2085&rft.isbn=&rft.btitle=&rft.title=Clinical+Chemistry&rft.issn=00099147&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Multipartite Regulation of rctB, the Replication Initiator Gene of Vibrio cholerae Chromosome II AN - 17662192; 6503238 AB - Replication initiator proteins in bacteria not only allow DNA replication but also often regulate the rate of replication initiation as well. The regulation is mediated by limiting the synthesis or availability of initiator proteins. The applicability of this principle is demonstrated here for RctB, the replication initiator for the smaller of the two chromosomes of Vibrio cholerae. A strong promoter for the rctB gene named rctBp was identified and found to be autoregulated in Escherichia coli. Promoter activity was lower in V. cholerae than in E. coli, and a part of this reduction is likely to be due to autorepression. Sequences upstream of rctBp, implicated earlier in replication control, enhanced the repression. The action of the upstream sequences required that they be present in cis, implying long-range interactions in the control of the promoter activity. A second gene specific for chromosome II replication, rctA, reduced rctB translation, most likely by antisense RNA control. Finally, optimal rctBp activity was found to be dependent on Dam. Increasing RctB in trans increased the copy number of a miniplasmid carrying oriCII sub(VC), implying that RctB can be rate limiting for chromosome II replication. The multiple modes of control on RctB are expected to reduce fluctuations in the initiator concentration and thereby help maintain chromosome copy number homeostasis. JF - Journal of Bacteriology AU - Pal, Debasish AU - Venkova-Canova, Tatiana AU - Srivastava, Preeti AU - Chattoraj, Dhruba K AD - Laboratory of Biochemistry, Center for Cancer Research, NCI, NIH, Bethesda, Maryland 20892 Y1 - 2005/11/01/ PY - 2005 DA - 2005 Nov 01 SP - 7167 EP - 7175 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 187 IS - 21 SN - 0021-9193, 0021-9193 KW - rctB gene KW - Microbiology Abstracts B: Bacteriology KW - J 02725:DNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17662192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Multipartite+Regulation+of+rctB%2C+the+Replication+Initiator+Gene+of+Vibrio+cholerae+Chromosome+II&rft.au=Pal%2C+Debasish%3BVenkova-Canova%2C+Tatiana%3BSrivastava%2C+Preeti%3BChattoraj%2C+Dhruba+K&rft.aulast=Pal&rft.aufirst=Debasish&rft.date=2005-11-01&rft.volume=187&rft.issue=21&rft.spage=7167&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-12-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Optimization of IPG strip equilibration for the basic membrane protein mABC1 AN - 17541180; 6399636 AB - Many proteins with extreme physical properties, including basic and acidic proteins, membrane proteins, and very large proteins, present specific challenges to 2-DE separation. Using a pressure-blotting approach, we demonstrate that a basic integral membrane protein, mitochondrial ATP-binding cassette protein 1 (mABC1), focuses in the IPG strip, but fails to enter into the 2-D SDS-PAGE gel. Through modifying the equilibration conditions between the IPG strip and 2nd dimension, we demonstrate that only by increasing both the volume (from 3 to 6 mL for a 7-cm strip) and SDS concentration (from 2 to 10%) of the equilibration buffer is migration of mABC1 into the 2nd dimension achieved. While 2-DE remains one of the core separation technologies of proteomic analysis, proteins that are extremely basic, hydrophobic, or of large mass present significant challenges to 2-DE separation due to aggregation, oxidation, precipitation, and the physical limitations of the 1-D IPG strip (for recent reviews, see [1-7]). Since the advent of commercially available IPG strips, numerous groups have experimented with IEF conditions using various detergents alone or in combination [8], alternative denaturants [9], and thiol oxidation agents [10] to improve protein focusing. Effective 2-DE separation of membrane proteins has been affected dramatically by these advances in protein solubilization, as well as improvements in isolation of membranes, delipidation, and active in-gel rehydration [11, for recent reviews see 4, 5, 7]. Since the development of commercially available basic IPG strips, the most significant advance in the separation of basic proteins has been the introduction of hydroxyethyldisulfides, either alone or in combination with DTT [10]. While hydrophobic proteins were once virtually absent from the 2-D gel, and basic proteins were only visible as dense streaks, now many groups are undertaking large-scale analyses of membranes and basic proteins. Using this base of experimental tools, we embarked on a proteomic analysis of cardiac mitochondrial membranes, hoping to combine the knowledge gained from ongoing targeted protein chemistry and molecular biology studies with a broader-based proteomic analysis. Of particular interest is the inner mitochondrial membrane protein mABC1 (mitochondrial ATP-binding cassette protein 1), which may play a significant role in cardioprotection as part of the mitochondrial ATP-sensitive potassium channels [12-14]. Therefore, in designing our 2-DE approach, it was crucial to ensure that mABC1 is focused, observable, and quantifiable, despite being an integral membrane protein of pI 9.37. JF - Proteomics AU - McDonough, Jason AU - Marban, Eduardo AD - Division of Cardiology, NHLBI Proteomics Center, Johns Hopkins University, Baltimore, MD, USA, marban@jhmi.edu Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 2892 EP - 2895 PB - Wiley-VCH, Postfach 101161 Weinheim 69451 Germany, [mailto:info@wiley-vch.de], [URL:http://www.wiley-vch.de/publish/en/] VL - 5 IS - 11 SN - 1615-9853, 1615-9853 KW - ABC1 protein KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Heart KW - Rehydration KW - Mitochondria KW - Hydrophobicity KW - Precipitation KW - Membrane proteins KW - Migration KW - Reviews KW - Thiols KW - Oxidation KW - proteomics KW - Potassium channels KW - W3 33340:Other proteins, peptides, amino acids KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17541180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics&rft.atitle=Optimization+of+IPG+strip+equilibration+for+the+basic+membrane+protein+mABC1&rft.au=McDonough%2C+Jason%3BMarban%2C+Eduardo&rft.aulast=McDonough&rft.aufirst=Jason&rft.date=2005-11-01&rft.volume=5&rft.issue=11&rft.spage=2892&rft.isbn=&rft.btitle=&rft.title=Proteomics&rft.issn=16159853&rft_id=info:doi/10.1002%2Fpmic.200401155 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Membrane proteins; Mitochondria; proteomics; Hydrophobicity; Reviews; Oxidation; Migration; Precipitation; Potassium channels; Rehydration; Heart; Thiols DO - http://dx.doi.org/10.1002/pmic.200401155 ER - TY - JOUR T1 - DDT serum concentration and menstruation among young Chinese women AN - 17464035; 6633889 AB - High DDE and DDT concentrations were found to be associated with shortened menstrual cycle length in Laotian immigrants to the United States. We examined this issue in a sample of young Chinese women. A total of 60 women aged 20-24 years were enrolled in three maternal and child health clinics (20 from urban, 20 from suburban, 20 from rural) in Shanghai, China, and vicinity, in 1998. Of these women, 47 who did not use hormonal contraceptives and had valid menstrual cycle characteristics were included in the analysis for associations among serum DDE and DDT concentration and menstrual cycle length, duration of menses, and heaviness of menstrual flow. In univariate analysis, higher p,p'-DDE concentration was associated with longer menstrual cycle length (0.66 day per 10 mu g /L, 95% confidence interval [CI]: 0.21, 1.11 day). With adjustment for age, body mass index, education, occupation, and resident location, the estimate was 0.42 day (95% CI: -0.35, 1.19 day). p,p'-DDE was not associated with duration of menses or heaviness of menstrual flow. Neither p,p'-DDT nor o,p'-DDT were associated with menstrual cycle length, duration of menses or heaviness of menstrual flow. The study largely suggests no association between DDE and DDT concentrations and menstrual cycle characteristics in young Chinese women, though the weak-to-no correlation of DDE with menstrual cycle length merits further study. JF - Environmental Research AU - Chen, A AU - Zhang, J AU - Zhou, L AU - Gao, Es AU - Chen, L AU - Rogan, W J AU - Wolff AD - National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA, zhangj@mail.nih.gov Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 397 EP - 402 VL - 99 IS - 3 SN - 0013-9351, 0013-9351 KW - Toxicology Abstracts KW - Menstrual cycle KW - DDE KW - DDT KW - Immigrants KW - Menstruation KW - China, People's Rep. KW - Body mass index KW - Contraceptives KW - X 24136:Environmental impact UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17464035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Research&rft.atitle=DDT+serum+concentration+and+menstruation+among+young+Chinese+women&rft.au=Chen%2C+A%3BZhang%2C+J%3BZhou%2C+L%3BGao%2C+Es%3BChen%2C+L%3BRogan%2C+W+J%3BWolff&rft.aulast=Chen&rft.aufirst=A&rft.date=2005-11-01&rft.volume=99&rft.issue=3&rft.spage=397&rft.isbn=&rft.btitle=&rft.title=Environmental+Research&rft.issn=00139351&rft_id=info:doi/10.1016%2Fj.envres.2004.12.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Menstrual cycle; DDT; DDE; Immigrants; Menstruation; Body mass index; Contraceptives; China, People's Rep. DO - http://dx.doi.org/10.1016/j.envres.2004.12.015 ER - TY - JOUR T1 - Current Review in Basic Science: Update on the Neurobiology of Alcohol Withdrawal Seizures AN - 17449216; 6546177 AB - Abrupt cessation of alcohol intake after prolonged heavy drinking may trigger alcohol withdrawal seizures. Generalized tonic-clonic seizures are the most characteristic and severe type of seizure that occur in this setting. Generalized seizures also occur in rodent models of alcohol withdrawal. In these models, the withdrawal seizures are triggered by neuronal networks in the brainstem, including the inferior colliculus; similar brainstem mechanisms may contribute to alcohol withdrawal seizures in humans. Alcohol causes intoxication through effects on diverse ion channels and neurotransmitter receptors, including GABA sub(A) receptors-particularly those containing delta subunits that are localized extrasynaptically and mediate tonic inhibition-and N-methyl-D-aspartate (NMDA) receptors. Alcohol dependence results from compensatory changes during prolonged alcohol exposure, including internalization of GABA sub(A) receptors, which allows adaptation to these effects. Withdrawal seizures are believed to reflect unmasking of these changes and may also involve specific withdrawal-induced cellular events, such as rapid increases in alpha 4 subunit-containing GABA sub(A) receptors that confer reduced inhibitory function. Optimizing approaches to the prevention of alcohol withdrawal seizures requires an understanding of the distinct neurobiologic mechanisms that underlie these seizures. JF - Epilepsy Currents AU - Rogawski, Michael A AD - Michael A. Rogawski, MD, PhD, Epilepsy Research Section, Porter Neuroscience Research Center, NINDS, NIH, Building 35, Room 1C-1002, 35 Convent Drive MSC 3702, Bethesda, MD 20892-3702, michael.rogawski@nih.gov Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 225 EP - 230 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 5 IS - 6 SN - 1535-7597, 1535-7597 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Intoxication KW - Drinking KW - Inferior colliculus KW - N-Methyl-D-aspartic acid receptors KW - Adaptations KW - Neural networks KW - Brain stem KW - Seizures KW - Glutamic acid receptors KW - Drug dependence KW - Epilepsy KW - Reviews KW - Neurotransmitter receptors KW - gamma -Aminobutyric acid A receptors KW - Ion channels KW - Ethanol KW - N3 11106:Neurobiology of drug abuse KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17449216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epilepsy+Currents&rft.atitle=Current+Review+in+Basic+Science%3A+Update+on+the+Neurobiology+of+Alcohol+Withdrawal+Seizures&rft.au=Rogawski%2C+Michael+A&rft.aulast=Rogawski&rft.aufirst=Michael&rft.date=2005-11-01&rft.volume=5&rft.issue=6&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Epilepsy+Currents&rft.issn=15357597&rft_id=info:doi/10.1111%2Fj.1535-7511.2005.00071.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - SuppNotes - Tables, 1; references, 96. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Drinking; Intoxication; Inferior colliculus; N-Methyl-D-aspartic acid receptors; Adaptations; Neural networks; Seizures; Brain stem; Glutamic acid receptors; Drug dependence; Epilepsy; Neurotransmitter receptors; Reviews; Ion channels; gamma -Aminobutyric acid A receptors; Ethanol DO - http://dx.doi.org/10.1111/j.1535-7511.2005.00071.x ER - TY - JOUR T1 - Accelerometer Data Reduction: A Comparison of Four Reduction Algorithms on Select Outcome Variables AN - 17421418; 6537843 AB - Accelerometers are recognized as a valid and objective tool to assess free-living physical activity. Despite the widespread use of accelerometers, there is no standardized way to process and summarize data from them, which limits our ability to compare results across studies. This paper a) reviews decision rules researchers have used in the past, b) compares the impact of using different decision rules on a common data set, and c) identifies issues to consider for accelerometer data reduction. The methods sections of studies published in 2003 and 2004 were reviewed to determine what decision rules previous researchers have used to identify wearing period, minimal wear requirement for a valid day, spurious data, number of days used to calculate the outcome variables, and extract bouts of moderate to vigorous physical activity (MVPA). For this study, four data reduction algorithms that employ different decision rules were used to analyze the same data set. The review showed that among studies that reported their decision rules, much variability was observed. Overall, the analyses suggested that using different algorithms impacted several important outcome variables. The most stringent algorithm yielded significantly lower wearing time, the lowest activity counts per minute and counts per day, and fewer minutes of MVPA per day. An exploratory sensitivity analysis revealed that the most stringent inclusion criterion had an impact on sample size and wearing time, which in turn affected many outcome variables. These findings suggest that the decision rules employed to process accelerometer data have a significant impact on important outcome variables. Until guidelines are developed, it will remain difficult to compare findings across studies. JF - Medicine & Science in Sports & Exercise AU - Masse, L C AU - Fuemmeler, B F AU - Anderson, C B AU - Matthews, CE AU - Trost, S G AU - Catellier, D J AU - Treuth, M AD - Health Promotion Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Executive Plaza North, Room 4080, 6130 Executive Boulevard, MSC 7335, Bethesda, MD 20892-7335, USA, massel@mail.nih.gov Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - S544 EP - S554 VL - 37 IS - 11 SN - 0195-9131, 0195-9131 KW - Physical Education Index KW - Issues KW - Analysis KW - Mainstreaming KW - Exercise KW - Rules KW - PE 070:Measurement & Evaluation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17421418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medicine+%26+Science+in+Sports+%26+Exercise&rft.atitle=Accelerometer+Data+Reduction%3A+A+Comparison+of+Four+Reduction+Algorithms+on+Select+Outcome+Variables&rft.au=Masse%2C+L+C%3BFuemmeler%2C+B+F%3BAnderson%2C+C+B%3BMatthews%2C+CE%3BTrost%2C+S+G%3BCatellier%2C+D+J%3BTreuth%2C+M&rft.aulast=Masse&rft.aufirst=L&rft.date=2005-11-01&rft.volume=37&rft.issue=11&rft.spage=S544&rft.isbn=&rft.btitle=&rft.title=Medicine+%26+Science+in+Sports+%26+Exercise&rft.issn=01959131&rft_id=info:doi/10.1249%2F01.mss.0000185674.09066.8a LA - English DB - Physical Education Index N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Issues; Analysis; Mainstreaming; Exercise; Rules DO - http://dx.doi.org/10.1249/01.mss.0000185674.09066.8a ER - TY - JOUR T1 - A Timely Meeting: Objective Measurement of Physical Activity AN - 17414468; 6537837 AB - Accurate and reliable assessment of physical activity remains an important challenge for epidemiologists, exercise scientists, clinicians, and behavioral researchers. The desire to explain and stem the dramatic increase in overweight and obesity prevalence observed among youths and adults has focused attention on the need for better measures of physical activity. These measures fall into three general categories: direct observation, subjective reports, and portable monitors, such as accelerometers. These monitors measure body movement in terms of acceleration, which can then be used to estimate physical activity intensity. As recently as 1999, accelerometry was still considered to be in the developmental stage. In October of that year, the Cooper Institute hosted a meeting titled "Measurement of Physical Activity." One of the conclusions from the meeting was that objective motion sensors were not practical for large-scale studies because of high cost, uncertain reliability, and difficulties in the interpretation of data. JF - Medicine & Science in Sports & Exercise AU - Troiano, R P AD - US Public Health Service, Risk Factor Monitoring and Methods Branch, Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, EPN 4005, 6130 Executive Blvd., MSC 7344, Bethesda, MD 20892-7344, USA, troianor@mail.nih.gov Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - S487 EP - S489 VL - 37 IS - 11 SN - 0195-9131, 0195-9131 KW - Physical Education Index KW - Measurement KW - Obesity KW - Reliability KW - Sport science KW - Observation KW - Exercise KW - Adults KW - Movement KW - Acceleration KW - Evaluation KW - Objectives KW - Youth KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17414468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medicine+%26+Science+in+Sports+%26+Exercise&rft.atitle=A+Timely+Meeting%3A+Objective+Measurement+of+Physical+Activity&rft.au=Troiano%2C+R+P&rft.aulast=Troiano&rft.aufirst=R&rft.date=2005-11-01&rft.volume=37&rft.issue=11&rft.spage=S487&rft.isbn=&rft.btitle=&rft.title=Medicine+%26+Science+in+Sports+%26+Exercise&rft.issn=01959131&rft_id=info:doi/10.1249%2F01.mss.0000185473.32846.c3 LA - English DB - Physical Education Index N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Evaluation; Obesity; Measurement; Reliability; Objectives; Sport science; Observation; Adults; Exercise; Acceleration; Movement; Youth DO - http://dx.doi.org/10.1249/01.mss.0000185473.32846.c3 ER - TY - JOUR T1 - Agricultural pesticide use and risk of glioma in Nebraska, United States AN - 17399374; 6508845 AB - BACKGROUND: To evaluate the risk of the adult glioma associated with farming and agricultural pesticide use, the authors conducted a population based case control study in eastern Nebraska. METHODS: Telephone interviews were conducted with men and women diagnosed with gliomas (n = 251) between 1988 and 1993 and controls (n = 498) randomly selected from the same geographical area. Unconditional logistic regression was used to calculate adjusted odds ratios (ORs) for farming and for use of individual and chemical classes of insecticides and herbicides, including pesticides classified as nitrosatable (able to form N-nitroso compounds upon reaction with nitrite). Non-farmers were used as the reference category for all analyses. RESULTS: Among men, ever living or working on a farm and duration of farming were associated with significantly increased risks of glioma ( greater than or equal to 55 years on a farm OR = 3.9, 95% CI 1.8 to 8.6); however, positive findings were limited to proxy respondents. Among women, there were no positive associations with farming activities among self or proxy respondents. Specific pesticide families and individual pesticides were associated with significantly increased risks among male farmers; however, most of the positive associations were limited to proxy respondents. For two herbicides and three insecticides, use was positively associated with risk among both self and proxy respondents. Based on a small number of exposed cases, ORs were significantly increased for the herbicides metribuzin (OR = 3.4, 95% CI 1.2 to 9.7) and paraquat (OR = 11.1, 95% CI 1.2 to 101), and for the insecticides bufencarb (OR = 18.9, 95% CI 1.9 to 187), chlorpyrifos (OR = 22.6, 95% CI 2.7 to 191), and coumaphos (OR = 5.9, 95% CI 1.1 to 32). CONCLUSION: The authors found significant associations between some specific agricultural pesticide exposures and the risk of glioma among male farmers but not among female farmers in Nebraska; however, most of the positive associations were limited to proxy respondents. These findings warrant further evaluation in prospective cohort studies where issues of recall bias are not a concern. JF - Occupational and Environmental Medicine AU - Lee, W J AU - Colt, J S AU - Heineman, E F AU - McComb, R AU - Weisenburger, D D AU - Lijinsky, W AU - Ward, M H AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 786 EP - 792 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 62 IS - 11 SN - 1351-0711, 1351-0711 KW - glioma KW - Risk Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - Farms KW - Herbicides KW - Agrochemicals KW - Brain tumors KW - Chlorpyrifos KW - N-Nitroso compounds KW - Insecticides KW - Nitrites KW - metribuzin KW - Pesticides KW - USA, Nebraska KW - Coumaphos KW - Glioma KW - Nitrite KW - Occupational exposure KW - Paraquat KW - R2 23080:Industrial and labor KW - H 5000:Pesticides KW - X 24136:Environmental impact UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17399374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Agricultural+pesticide+use+and+risk+of+glioma+in+Nebraska%2C+United+States&rft.au=Lee%2C+W+J%3BColt%2C+J+S%3BHeineman%2C+E+F%3BMcComb%2C+R%3BWeisenburger%2C+D+D%3BLijinsky%2C+W%3BWard%2C+M+H&rft.aulast=Lee&rft.aufirst=W&rft.date=2005-11-01&rft.volume=62&rft.issue=11&rft.spage=786&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-01-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Chlorpyrifos; Brain tumors; N-Nitroso compounds; Farms; Insecticides; metribuzin; Pesticides; Coumaphos; Herbicides; Glioma; Nitrite; Paraquat; Nitrites; Agrochemicals; Occupational exposure; USA, Nebraska ER - TY - JOUR T1 - Recombinant Newcastle Disease Virus Expressing a Foreign Viral Antigen Is Attenuated and Highly Immunogenic in Primates AN - 17394573; 6504680 AB - Paramyxoviruses such as human parainfluenza viruses that bear inserts encoding protective antigens of heterologous viruses can induce an effective immunity against the heterologous viruses in experimental animals. However, vectors based on common human pathogens would be expected to be restricted in replication in the adult human population due to high seroprevalence, an effect that would reduce vector immunogenicity. To address this issue, we evaluated Newcastle disease virus (NDV), an avian paramyxovirus that is serotypically distinct from common human pathogens, as a vaccine vector. Two strains were evaluated: the attenuated vaccine strain LaSota (NDV-LS) that replicates mostly in the chicken respiratory tract and the Beaudette C (NDV-BC) strain of intermediate virulence that produces mild systemic infection in chickens. A recombinant version of each virus was modified by the insertion, between the P and M genes, of a gene cassette encoding the human parainfluenza virus type 3 (HPIV3) hemagglutinin-neuraminidase (HN) protein, a test antigen with considerable historic data. The recombinant viruses were administered to African green monkeys (NDV-BC and NDV-LS) and rhesus monkeys (NDV-BC only) by combined intranasal and intratracheal routes at a dose of 10 super(6.5) PFU per site, with a second equivalent dose administered 28 days later. Little or no virus shedding was detected in nose-throat swabs or tracheal lavages following immunization with either strain. In a separate experiment, direct examination of lung tissue confirmed a highly attenuated, restricted pattern of replication by parental NDV-BC. The serum antibody response to the foreign HN protein induced by the first immunization with either NDV vector was somewhat less than that observed following a wild-type HPIV3 infection; however, the titer following the second dose exceeded that observed with HPIV3 infection, even though HPIV3 replicates much more efficiently than NDV in these animals. NDV appears to be a promising vector for the development of vaccines for humans; one application would be in controlling localized outbreaks of emerging pathogens. JF - Journal of Virology AU - Bukreyev, Alexander AU - Huang, Zhuhui AU - Yang, Lijuan AU - Elankumaran, Subbiah AU - St Claire, Marisa AU - Murphy, Brian R AU - Samal, Siba K AU - Collins, Peter L AD - Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892. Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland 20742. Bioqual, Rockville, Maryland 20850 Y1 - 2005/11/01/ PY - 2005 DA - 2005 Nov 01 SP - 13275 EP - 13284 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 79 IS - 21 SN - 0022-538X, 0022-538X KW - Rhesus macaque KW - Rhesus monkey KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - Data processing KW - Replication KW - Disseminated infection KW - protective antigen KW - Paramyxovirus KW - Newcastle disease KW - Pathogens KW - Immunity KW - Antibody response KW - Primates KW - Immunization KW - Parainfluenza virus KW - Parainfluenza KW - Virulence KW - Newcastle disease virus KW - Immunogenicity KW - Lung KW - Insertion KW - Macaca mulatta KW - Vaccines KW - Trachea KW - Respiratory tract KW - double prime HN protein KW - W3 33365:Vaccines (other) KW - G 07313:Viruses KW - F 06100:Vaccines - active immunity KW - W 30965:Miscellaneous, Reviews KW - V 22092:Viral antigenic properties UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17394573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Recombinant+Newcastle+Disease+Virus+Expressing+a+Foreign+Viral+Antigen+Is+Attenuated+and+Highly+Immunogenic+in+Primates&rft.au=Bukreyev%2C+Alexander%3BHuang%2C+Zhuhui%3BYang%2C+Lijuan%3BElankumaran%2C+Subbiah%3BSt+Claire%2C+Marisa%3BMurphy%2C+Brian+R%3BSamal%2C+Siba+K%3BCollins%2C+Peter+L&rft.aulast=Bukreyev&rft.aufirst=Alexander&rft.date=2005-11-01&rft.volume=79&rft.issue=21&rft.spage=13275&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Data processing; Replication; protective antigen; Disseminated infection; Antibody response; Immunity; Pathogens; Newcastle disease; Immunization; Parainfluenza; Virulence; Insertion; Lung; Immunogenicity; Vaccines; Trachea; double prime HN protein; Respiratory tract; Newcastle disease virus; Paramyxovirus; Macaca mulatta; Primates; Parainfluenza virus ER - TY - JOUR T1 - Combinations of Polyclonal or Monoclonal Antibodies to Proteins of the Outer Membranes of the Two Infectious Forms of Vaccinia Virus Protect Mice against a Lethal Respiratory Challenge AN - 17394199; 6504696 AB - Previous studies demonstrated that antibodies to live vaccinia virus infection are needed for optimal protection against orthopoxvirus infection. The present report is the first to compare the protective abilities of individual and combinations of specific polyclonal and monoclonal antibodies that target proteins of the intracellular (IMV) and extracellular (EV) forms of vaccinia virus. The antibodies were directed to one IMV membrane protein, L1, and to two outer EV membrane proteins, A33 and B5. In vitro studies showed that the antibodies to L1 neutralized IMV and that the antibodies to A33 and B5 prevented the spread of EV in liquid medium. Prophylactic administration of individual antibodies to BALB/c mice partially protected them against disease following intranasal challenge with lethal doses of vaccinia virus. Combinations of antibodies, particularly anti-L1 and -A33 or -L1 and -B5, provided enhanced protection when administered 1 day before or 2 days after challenge. Furthermore, the protection was superior to that achieved with pooled immune gamma globulin from human volunteers inoculated with live vaccinia virus. In addition, single injections of anti-L1 plus anti-A33 antibodies greatly delayed the deaths of severe combined immunodeficiency mice challenged with vaccinia virus. These studies suggest that antibodies to two or three viral membrane proteins optimally derived from the outer membranes of IMV and EV, may be beneficial for prophylaxis or therapy of orthopoxvirus infections. JF - Journal of Virology AU - Lustig, Shlomo AU - Fogg, Christiana AU - Whitbeck, JCharles AU - Eisenberg, Roselyn J AU - Cohen, Gary H AU - Moss, Bernard AD - Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland. Schools of Dental and Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Y1 - 2005/11/01/ PY - 2005 DA - 2005 Nov 01 SP - 13454 EP - 13462 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 79 IS - 21 SN - 0022-538X, 0022-538X KW - mice KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Virology & AIDS Abstracts KW - Orthopoxvirus KW - Monoclonal antibodies KW - Outer membranes KW - Globulins KW - Membrane proteins KW - Vaccinia virus KW - Prophylaxis KW - Severe combined immunodeficiency KW - Lethal dose KW - W3 33160:Antibody based KW - V 22091:Immunological techniques & reagents KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17394199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Combinations+of+Polyclonal+or+Monoclonal+Antibodies+to+Proteins+of+the+Outer+Membranes+of+the+Two+Infectious+Forms+of+Vaccinia+Virus+Protect+Mice+against+a+Lethal+Respiratory+Challenge&rft.au=Lustig%2C+Shlomo%3BFogg%2C+Christiana%3BWhitbeck%2C+JCharles%3BEisenberg%2C+Roselyn+J%3BCohen%2C+Gary+H%3BMoss%2C+Bernard&rft.aulast=Lustig&rft.aufirst=Shlomo&rft.date=2005-11-01&rft.volume=79&rft.issue=21&rft.spage=13454&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Vaccinia virus; Orthopoxvirus; Membrane proteins; Monoclonal antibodies; Outer membranes; Prophylaxis; Globulins; Lethal dose; Severe combined immunodeficiency ER - TY - JOUR T1 - Intranasal Immunization Strategy To Impede Pilin-Mediated Binding of Pseudomonas aeruginosa to Airway Epithelial Cells AN - 17394145; 6503163 AB - Prevention of pulmonary Pseudomonas aeruginosa infections represents a critical unmet medical need for cystic fibrosis (CF) patients. We have examined the tenet that a mucosal immunization approach can reduce interactions of a piliated form of this opportunistic pathogen with respiratory epithelial cells. Vaccinations were performed using ntPEpilinPAK, a protein chimera composed of a nontoxic form of P. aeruginosa exotoxin A (ntPE), where the C-terminal loop amino acid sequence of the PAK strain pilin protein was inserted in place of the ntPE Ib domain. Intranasal (i.n.) immunization of BALB/c mice with ntPEpilinPAK generated both serum and saliva immune responses. A series of in vitro studies showed that diluted samples of saliva obtained from immunized mice reduced pilin-dependent P. aeruginosa binding to polarized human tracheal epithelial cells, protected human pulmonary epithelial cells from cytotoxic actions associated with bacterial challenge, and reduced exotoxin A toxicity. Overall, i.n. administration of ntPEpilinPAK induced mucosal and systemic immune responses that may be beneficial for blocking early stage adhesion and/or infection events of epithelial cell-P. aeruginosa interactions at oropharyngeal surfaces. JF - Infection and Immunity AU - Hsieh, Jennifer C AU - Tham, Doris M AU - Feng, Weijun AU - Huang, Fan AU - Embaie, Selamawit AU - Liu, Keyi AU - Dean, Deborah AU - Hertle, Ralf AU - FitzGerald, David J AU - Mrsny, Randall J AD - Trinity BioSystems, Inc., 1455 Adams Dr., Suite 1317, Menlo Park, California 94025-1438. Department of Medicine, University of California at San Francisco School of Medicine, San Francisco, California 94143, and Children's Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, California 94609. Biotherapy Section, Laboratory of Molecular Biology, CCR, National Cancer Institute, Bethesda, Maryland 20892-4255. University of Tuebingen, Institute of Microbiology/Membrane Physiology, Auf der Morgenstelle 28, D-72076 Tuebingen, Germany Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 7705 EP - 7717 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 73 IS - 11 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Epithelial cells KW - Mucosal immunity KW - pilin KW - Pathogens KW - Toxicity KW - Infection KW - Vaccination KW - exotoxin A KW - Immunization KW - Chimeras KW - Cytotoxicity KW - Lung KW - Saliva KW - Pseudomonas aeruginosa KW - Cystic fibrosis KW - Respiratory tract KW - Amino acid sequence KW - J 02834:Vaccination and immunization KW - F 06100:Vaccines - active immunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17394145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Intranasal+Immunization+Strategy+To+Impede+Pilin-Mediated+Binding+of+Pseudomonas+aeruginosa+to+Airway+Epithelial+Cells&rft.au=Hsieh%2C+Jennifer+C%3BTham%2C+Doris+M%3BFeng%2C+Weijun%3BHuang%2C+Fan%3BEmbaie%2C+Selamawit%3BLiu%2C+Keyi%3BDean%2C+Deborah%3BHertle%2C+Ralf%3BFitzGerald%2C+David+J%3BMrsny%2C+Randall+J&rft.aulast=Hsieh&rft.aufirst=Jennifer&rft.date=2005-11-01&rft.volume=73&rft.issue=11&rft.spage=7705&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Mucosal immunity; pilin; Toxicity; Pathogens; Infection; exotoxin A; Vaccination; Immunization; Chimeras; Cytotoxicity; Lung; Saliva; Cystic fibrosis; Amino acid sequence; Respiratory tract; Pseudomonas aeruginosa ER - TY - JOUR T1 - Laser-Capture Microdissection: Refining Estimates of the Quantity and Distribution of Latent Herpes Simplex Virus 1 and Varicella-Zoster Virus DNA in Human Trigeminal Ganglia at the Single-Cell Level AN - 17394012; 6504760 AB - There remains uncertainty and some controversy about the percentages and types of cells in human sensory nerve ganglia that harbor latent herpes simplex virus 1 (HSV-1) and varicella-zoster virus (VZV) DNA. We developed and validated laser-capture microdissection and real-time PCR (LCM/PCR) assays for the presence and copy numbers of HSV-1 gG and VZV gene 62 sequences in single cells recovered from sections of human trigeminal ganglia (TG) obtained at autopsy. Among 970 individual sensory neurons from five subjects, 2.0 to 10.5% were positive for HSV-1 DNA, with a median of 11.3 copies/positive cell, compared with 0.2 to 1.5% of neurons found to be positive by in situ hybridization (ISH) for HSV-1 latency-associated transcripts (LAT), the classical surrogate marker for HSV latency. This indicates a more pervasive latent HSV-1 infection of human TG neurons than originally thought. Combined ISH/LCM/PCR assays revealed that the majority of the latently infected neurons do not accumulate LAT to detectable levels. We detected VZV DNA in 1.0 to 6.9% of individual neurons from 10 subjects. Of the total 1,722 neurons tested, 4.1% were VZV DNA positive, with a median of 6.9 viral genomes/positive cell. After removal by LCM of all visible neurons on a slide, all surrounding nonneuronal cells were harvested and assayed: 21 copies of HSV-1 DNA were detected in similar to 5,200 nonneuronal cells, while nine VZV genomes were detected in similar to 14,200 nonneuronal cells. These data indicate that both HSV-1 and VZV DNAs persist in human TG primarily, if not exclusively, in a moderate percentage of neuronal cells. JF - Journal of Virology AU - Wang, Kening AU - Lau, Tsz Y AU - Morales, Melissa AU - Mont, Erik K AU - Straus, Stephen E AD - Medical Virology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 14079 EP - 14087 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 79 IS - 22 SN - 0022-538X, 0022-538X KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Genomes KW - Autopsy KW - Infection KW - Polymerase chain reaction KW - Latent infection KW - Sensory neurons KW - Herpes simplex virus 1 KW - Trigeminal ganglion KW - copy number KW - Varicella-zoster virus KW - Ganglia KW - N 14025:RNA/DNA role in infection & immune response KW - V 22022:Virus assay KW - W 30965:Miscellaneous, Reviews KW - W3 33250:Methods: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17394012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Laser-Capture+Microdissection%3A+Refining+Estimates+of+the+Quantity+and+Distribution+of+Latent+Herpes+Simplex+Virus+1+and+Varicella-Zoster+Virus+DNA+in+Human+Trigeminal+Ganglia+at+the+Single-Cell+Level&rft.au=Wang%2C+Kening%3BLau%2C+Tsz+Y%3BMorales%2C+Melissa%3BMont%2C+Erik+K%3BStraus%2C+Stephen+E&rft.aulast=Wang&rft.aufirst=Kening&rft.date=2005-11-01&rft.volume=79&rft.issue=22&rft.spage=14079&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Herpes simplex virus 1; Varicella-zoster virus; Polymerase chain reaction; Sensory neurons; Genomes; Trigeminal ganglion; copy number; Ganglia; Latent infection; Autopsy; Infection ER - TY - JOUR T1 - Liver-Directed Gamma Interferon Gene Delivery in Chronic Hepatitis C AN - 17392307; 6504692 AB - Gamma interferon (IFN- gamma ) has been shown to inhibit replication of subgenomic and genomic hepatitis C virus (HCV) RNAs in vitro and to noncytolytically suppress hepatitis B virus (HBV) replication in vivo. IFN- gamma is also known for its immunomodulatory effects and as a marker of a successful cellular immune response to HCV. Therapeutic expression of IFN- gamma in the liver may therefore facilitate resolution of chronic hepatitis C, an infection that is rarely resolved spontaneously. To analyze immunomodulatory and antiviral effects of liver-specific IFN- gamma expression in vivo, we intravenously injected two persistently HCV-infected chimpanzees twice with a recombinant, replication-deficient HBV vector and subsequently with a recombinant adenoviral vector. These vectors expressed human IFN- gamma under control of HBV- and liver-specific promoters, respectively. Gene transfer resulted in a transient increase of intrahepatic IFN- gamma mRNA, without increase in serum alanine aminotransferase levels. Ex vivo analysis of peripheral blood lymphocytes demonstrated enhanced CD16 expression on T cells and upregulation of the liver-homing marker CXCR3. Moreover, an increased frequency of HCV-specific T cells was detected ex vivo in the peripheral blood and in vitro in liver biopsy-derived, antigen-nonspecifically expanded T-cell lines. None of these immunologic effects were observed in the third chimpanzee injected with an HBV control vector. Despite these immunologic effects of the experimental vector, however, IFN- gamma gene transfer did not result in a significant and long-lasting decrease of HCV titers. In conclusion, liver-directed IFN- gamma gene delivery resulted in HCV-specific and nonspecific activation of cellular immune responses but did not result in effective control of HCV replication. JF - Journal of Virology AU - Shin, Eui-Cheol AU - Protzer, Ulrike AU - Untergasser, Andreas AU - Feinstone, Stephen M AU - Rice, Charles M AU - Hasselschwert, Dana AU - Rehermann, Barbara AD - Liver Diseases Branch, NIDDK, National Institutes of Health, DHHS, Bethesda, Maryland Y1 - 2005/11/01/ PY - 2005 DA - 2005 Nov 01 SP - 13412 EP - 13420 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 79 IS - 21 SN - 0022-538X, 0022-538X KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Bioengineering Abstracts; Virology & AIDS Abstracts KW - gamma -Interferon KW - Hepatitis B virus KW - CD16 antigen KW - CXCR3 protein KW - Replication KW - Peripheral blood KW - Alanine transaminase KW - Immunomodulation KW - Pan troglodytes KW - mRNA KW - Expression vectors KW - Promoters KW - Hepatitis C virus KW - Gene transfer KW - Chronic infection KW - Liver KW - Lymphocytes T KW - genomics KW - Hepatitis C KW - Immune response KW - G 07720:Immunogenetics KW - W3 33181:Gene therapy vectors KW - W 30965:Miscellaneous, Reviews KW - V 22095:Interferon KW - F 06104:Virus KW - W4 120:Genetic Engineering in Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17392307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Liver-Directed+Gamma+Interferon+Gene+Delivery+in+Chronic+Hepatitis+C&rft.au=Shin%2C+Eui-Cheol%3BProtzer%2C+Ulrike%3BUntergasser%2C+Andreas%3BFeinstone%2C+Stephen+M%3BRice%2C+Charles+M%3BHasselschwert%2C+Dana%3BRehermann%2C+Barbara&rft.aulast=Shin&rft.aufirst=Eui-Cheol&rft.date=2005-11-01&rft.volume=79&rft.issue=21&rft.spage=13412&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-01-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; CD16 antigen; Replication; CXCR3 protein; Peripheral blood; Alanine transaminase; Immunomodulation; mRNA; Expression vectors; Promoters; Gene transfer; Chronic infection; Lymphocytes T; Liver; Immune response; Hepatitis C; genomics; Hepatitis C virus; Hepatitis B virus; Pan troglodytes ER - TY - JOUR T1 - Crystal structure of the N-terminal domain of E. coli Lon protease AN - 17384087; 6508287 AB - We report here the first crystal structure of the N-terminal domain of an A-type Lon protease. Lon proteases are ubiquitous, multidomain, ATP-dependent enzymes with both highly specific and non-specific protein binding, unfolding, and degrading activities. We expressed and purified a stable, monomeric 119-amino acid N-terminal subdomain of the Escherichia coli A-type Lon protease and determined its crystal structure at 2.03 Aa (Protein Data Bank [PDB] code 2ANE). The structure was solved in two crystal forms, yielding 14 independent views. The domain exhibits a unique fold consisting primarily of three twisted beta -sheets and a single long alpha -helix. Analysis of recent PDB depositions identified a similar fold in BPP1347 (PDB code 1ZBO), a 203-amino acid protein of unknown function from Bordetella parapertussis, crystallized as part of a structural genomics effort. BPP1347 shares sequence homology with Lon N-domains and with a family of other independently expressed proteins of unknown functions. We postulate that, as is the case in Lon proteases, this structural domain represents a general protein and polypeptide interaction domain. JF - Protein Science AU - Li, Mi AU - Rasulova, Fatima AU - Melnikov, Edward E AU - Rotanova, Tatyana V AU - Gustchina, Alla AU - Maurizi, Michael R AU - Wlodawer, Alexander AD - Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, Maryland 21702-1201, USA. Basic Research Program, SAIC-Frederick, Frederick, Maryland 21702, USA. Laboratory of Cell Biology, National Cancer Institute, Bethesda, Maryland 20892, USA. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russia Y1 - 2005/11// PY - 2005 DA - Nov 2005 SP - 2895 EP - 2900 PB - Cold Spring Harbor Laboratory Press, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 14 IS - 11 SN - 0961-8368, 0961-8368 KW - Microbiology Abstracts B: Bacteriology KW - Data banks KW - Protein folding KW - Bordetella parapertussis KW - Escherichia coli KW - Crystal structure KW - Proteinase KW - genomics KW - J 02728:Enzymes KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17384087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Science&rft.atitle=Crystal+structure+of+the+N-terminal+domain+of+E.+coli+Lon+protease&rft.au=Li%2C+Mi%3BRasulova%2C+Fatima%3BMelnikov%2C+Edward+E%3BRotanova%2C+Tatyana+V%3BGustchina%2C+Alla%3BMaurizi%2C+Michael+R%3BWlodawer%2C+Alexander&rft.aulast=Li&rft.aufirst=Mi&rft.date=2005-11-01&rft.volume=14&rft.issue=11&rft.spage=2895&rft.isbn=&rft.btitle=&rft.title=Protein+Science&rft.issn=09618368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Data banks; Protein folding; Crystal structure; Proteinase; genomics; Escherichia coli; Bordetella parapertussis ER - TY - JOUR T1 - Efficient secretion of a folded protein domain by a monomeric bacterial autotransporter AN - 1439223009; 18436322 AB - Bacterial autotransporters are proteins that contain a small C-terminal ' beta domain' that facilitates translocation of a large N-terminal 'passenger domain' across the outer membrane (OM) by an unknown mechanism. Here we used EspP, an autotransporter produced by Escherichia coli 0157:H7, as a model protein to gain insight into the transport reaction. Initially we found that the passenger domain of a truncated version of EspP (EspP Delta 1-851) was translocated efficiently across the OM. Blue Native polyacrylamide gel electrophoresis, analytical ultracentrifugation and other biochemical methods showed that EspP Delta 1-851 behaves as a compact monomer and strongly suggest that the channel formed by the beta domain is too narrow to accommodate folded polypeptides. Surprisingly, we found that a folded protein domain fused to the N-terminus of EspP Delta 1-851 was efficiently translocated across the OM. Further analysis revealed that the passenger domain of wild-type EspP also folds at least partially in the periplasm. To reconcile these data, we propose that the EspP beta domain functions primarily to target and anchor the protein and that an external factor transports the passenger domain across the OM. JF - Molecular Microbiology AU - Skillman, Kristen M AU - Barnard, Travis J AU - Peterson, Janine H AU - Ghirlando, Rodolfo AU - Bernstein, Harris D AD - Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2005/11// PY - 2005 DA - November 2005 SP - 945 EP - 958 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 IS - 4 SN - 0950-382X, 0950-382X KW - Microbiology Abstracts B: Bacteriology KW - Monomers KW - Data processing KW - Secretion KW - Outer membranes KW - Escherichia coli KW - Ultracentrifugation KW - Translocation KW - periplasm KW - Gel electrophoresis KW - Models KW - N-Terminus KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1439223009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Efficient+secretion+of+a+folded+protein+domain+by+a+monomeric+bacterial+autotransporter&rft.au=Skillman%2C+Kristen+M%3BBarnard%2C+Travis+J%3BPeterson%2C+Janine+H%3BGhirlando%2C+Rodolfo%3BBernstein%2C+Harris+D&rft.aulast=Skillman&rft.aufirst=Kristen&rft.date=2005-11-01&rft.volume=58&rft.issue=4&rft.spage=945&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2005.04885.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-10-01 N1 - Document feature - figure 6 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Monomers; Data processing; Secretion; Outer membranes; periplasm; Translocation; Ultracentrifugation; Gel electrophoresis; N-Terminus; Models; Escherichia coli DO - http://dx.doi.org/10.1111/j.1365-2958.2005.04885.x ER - TY - CPAPER T1 - The Epidemiology of Second Cancers T2 - Fourth Annual AACR International Conference on Frontiers in Cancer Prevention Research AN - 40130915; 4016251 JF - Fourth Annual AACR International Conference on Frontiers in Cancer Prevention Research AU - Travis, Lois B Y1 - 2005/10/30/ PY - 2005 DA - 2005 Oct 30 KW - Cancer KW - Epidemiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40130915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fourth+Annual+AACR+International+Conference+on+Frontiers+in+Cancer+Prevention+Research&rft.atitle=The+Epidemiology+of+Second+Cancers&rft.au=Travis%2C+Lois+B&rft.aulast=Travis&rft.aufirst=Lois&rft.date=2005-10-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fourth+Annual+AACR+International+Conference+on+Frontiers+in+Cancer+Prevention+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/page4372.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chemoprevention of Lung Cancer: Whats Next? T2 - Fourth Annual AACR International Conference on Frontiers in Cancer Prevention Research AN - 40111758; 4016240 JF - Fourth Annual AACR International Conference on Frontiers in Cancer Prevention Research AU - Szabo, Eva Y1 - 2005/10/30/ PY - 2005 DA - 2005 Oct 30 KW - Lung cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40111758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fourth+Annual+AACR+International+Conference+on+Frontiers+in+Cancer+Prevention+Research&rft.atitle=Chemoprevention+of+Lung+Cancer%3A+Whats+Next%3F&rft.au=Szabo%2C+Eva&rft.aulast=Szabo&rft.aufirst=Eva&rft.date=2005-10-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fourth+Annual+AACR+International+Conference+on+Frontiers+in+Cancer+Prevention+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/page4372.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Targeting the PI3K/Akt/mTOR Pathway for Cancer Prevention T2 - Fourth Annual AACR International Conference on Frontiers in Cancer Prevention Research AN - 40101047; 4016249 JF - Fourth Annual AACR International Conference on Frontiers in Cancer Prevention Research AU - Dennis, Phillip A Y1 - 2005/10/30/ PY - 2005 DA - 2005 Oct 30 KW - prevention KW - 1-Phosphatidylinositol 3-kinase KW - Cancer KW - AKT protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40101047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fourth+Annual+AACR+International+Conference+on+Frontiers+in+Cancer+Prevention+Research&rft.atitle=Targeting+the+PI3K%2FAkt%2FmTOR+Pathway+for+Cancer+Prevention&rft.au=Dennis%2C+Phillip+A&rft.aulast=Dennis&rft.aufirst=Phillip&rft.date=2005-10-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fourth+Annual+AACR+International+Conference+on+Frontiers+in+Cancer+Prevention+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/page4372.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genomic and Proteomic Approaches for Cancer "Signatures" and Antiangiogenic Therapy T2 - Fourth Annual AACR International Conference on Frontiers in Cancer Prevention Research AN - 40100829; 4016192 JF - Fourth Annual AACR International Conference on Frontiers in Cancer Prevention Research AU - Kohn, Elise C Y1 - 2005/10/30/ PY - 2005 DA - 2005 Oct 30 KW - Therapy KW - proteomics KW - Cancer KW - genomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40100829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fourth+Annual+AACR+International+Conference+on+Frontiers+in+Cancer+Prevention+Research&rft.atitle=Genomic+and+Proteomic+Approaches+for+Cancer+%22Signatures%22+and+Antiangiogenic+Therapy&rft.au=Kohn%2C+Elise+C&rft.aulast=Kohn&rft.aufirst=Elise&rft.date=2005-10-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fourth+Annual+AACR+International+Conference+on+Frontiers+in+Cancer+Prevention+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/page4372.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Trends and Determinants of Cancer Screening Uptake T2 - Fourth Annual AACR International Conference on Frontiers in Cancer Prevention Research AN - 40067720; 4016216 JF - Fourth Annual AACR International Conference on Frontiers in Cancer Prevention Research AU - Meissner, Helen I Y1 - 2005/10/30/ PY - 2005 DA - 2005 Oct 30 KW - Screening KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40067720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fourth+Annual+AACR+International+Conference+on+Frontiers+in+Cancer+Prevention+Research&rft.atitle=Trends+and+Determinants+of+Cancer+Screening+Uptake&rft.au=Meissner%2C+Helen+I&rft.aulast=Meissner&rft.aufirst=Helen&rft.date=2005-10-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fourth+Annual+AACR+International+Conference+on+Frontiers+in+Cancer+Prevention+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/page4372.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - U.S. Demographic Imperative: Implication for the Science and Practice of Cancer Prevention in Older Persons T2 - Fourth Annual AACR International Conference on Frontiers in Cancer Prevention Research AN - 40056016; 4016273 JF - Fourth Annual AACR International Conference on Frontiers in Cancer Prevention Research AU - Yancik, Rosemary Y1 - 2005/10/30/ PY - 2005 DA - 2005 Oct 30 KW - USA KW - prevention KW - Demography KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40056016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fourth+Annual+AACR+International+Conference+on+Frontiers+in+Cancer+Prevention+Research&rft.atitle=U.S.+Demographic+Imperative%3A+Implication+for+the+Science+and+Practice+of+Cancer+Prevention+in+Older+Persons&rft.au=Yancik%2C+Rosemary&rft.aulast=Yancik&rft.aufirst=Rosemary&rft.date=2005-10-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fourth+Annual+AACR+International+Conference+on+Frontiers+in+Cancer+Prevention+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/page4372.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SNP Selection for Genome Wide Association Studies T2 - Fourth Annual AACR International Conference on Frontiers in Cancer Prevention Research AN - 40049367; 4016199 JF - Fourth Annual AACR International Conference on Frontiers in Cancer Prevention Research AU - Thomas, Gilles Y1 - 2005/10/30/ PY - 2005 DA - 2005 Oct 30 KW - Genomes KW - Single-nucleotide polymorphism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40049367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fourth+Annual+AACR+International+Conference+on+Frontiers+in+Cancer+Prevention+Research&rft.atitle=SNP+Selection+for+Genome+Wide+Association+Studies&rft.au=Thomas%2C+Gilles&rft.aulast=Thomas&rft.aufirst=Gilles&rft.date=2005-10-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fourth+Annual+AACR+International+Conference+on+Frontiers+in+Cancer+Prevention+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/page4372.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Macrophage Differentiation and Foam Cell Formation T2 - 6th International Congress on Coronary Artery Disease: from Prevention to Intervention AN - 39741662; 4018768 JF - 6th International Congress on Coronary Artery Disease: from Prevention to Intervention AU - Kruth, H S AU - Zhao, B AU - Li, Y F AU - Waldo, S W AU - Buono, C AU - Jones, N L Y1 - 2005/10/29/ PY - 2005 DA - 2005 Oct 29 KW - Differentiation KW - Macrophages KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39741662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+International+Congress+on+Coronary+Artery+Disease%3A+from+Prevention+to+Intervention&rft.atitle=Macrophage+Differentiation+and+Foam+Cell+Formation&rft.au=Kruth%2C+H+S%3BZhao%2C+B%3BLi%2C+Y+F%3BWaldo%2C+S+W%3BBuono%2C+C%3BJones%2C+N+L&rft.aulast=Kruth&rft.aufirst=H&rft.date=2005-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+International+Congress+on+Coronary+Artery+Disease%3A+from+Prevention+to+Intervention&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/cad6/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - A single pair of acidic residues in the kinase major groove mediates strong substrate preference for P-2 or P-5 arginine in the AGC, CAMK, and STE kinase families. AN - 68719290; 16131491 AB - Most basophilic serine/threonine kinases preferentially phosphorylate substrates with Arg at P-3 but vary greatly in additional strong preference for Arg at P-2 or P-5. The structural basis for P-2 or P-5 preference is known for two AGC kinases (family of protein kinases A, G, and C) in which it is mediated by a single pair of acidic residues (PEN+1 and YEM+1). We sought a general understanding of P-2 and P-5 Arg preference. The strength of Arg preference at each position was assessed in 15 kinases using a new degenerate peptide library approach. Strong P-2 or P-5 Arg preference occurred not only in AGC kinases (7 of 8 studied) but also in calmodulin-dependent protein kinase (CAMK, 1 of 3) and Ste20 (STE) kinases (2 of 4). Analysis of sequence conservation demonstrated almost perfect correlation between (a) strong P-2 or P-5 Arg preference and (b) acidic residues at both PEN+1 and YEM+1. Mutation of two kinases (PKC-theta and p21-activated kinase 1 (PAK1)) confirmed critical roles of both PEN+1 and YEM+1 residues in determining strong R-2 Arg preference. PAK kinases were unique in having exceptionally strong Arg preference at P-2 but lacking strong Arg preference at P-3. Preference for Arg at P-2 was so critical to PAK recognition that PAK1 activity was virtually eliminated by mutating the PEN+1 or YEM+1 residues. The fact that this specific pair of acidic residues has been repeatedly and exclusively used by evolution for conferring strong Arg preference at two different substrate positions in three different kinase families implies it is uniquely well suited to mediate sufficiently good substrate binding without unduly restricting product release. JF - The Journal of biological chemistry AU - Zhu, Guozhi AU - Fujii, Koichi AU - Liu, Yin AU - Codrea, Vlad AU - Herrero, Juan AU - Shaw, Stephen AD - Experimental Immunology Branch, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2005/10/28/ PY - 2005 DA - 2005 Oct 28 SP - 36372 EP - 36379 VL - 280 IS - 43 SN - 0021-9258, 0021-9258 KW - Isoenzymes KW - 0 KW - Peptides KW - PRKCQ protein, human KW - 148374-93-0 KW - Arginine KW - 94ZLA3W45F KW - Protein Kinases KW - EC 2.7.- KW - protein kinase C zeta KW - EC 2.7.11.1 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Calcium-Calmodulin-Dependent Protein Kinases KW - EC 2.7.11.17 KW - Index Medicus KW - Animals KW - Chromatography KW - Models, Molecular KW - Humans KW - Amino Acid Sequence KW - Mice KW - Protein Binding KW - Biotinylation KW - Isoenzymes -- metabolism KW - Mutagenesis KW - Protein Kinase C -- metabolism KW - Mutagenesis, Site-Directed KW - Protein Kinases -- metabolism KW - Blotting, Western KW - Phosphorylation KW - Kinetics KW - Molecular Sequence Data KW - Peptides -- chemistry KW - Calcium-Calmodulin-Dependent Protein Kinases -- chemistry KW - Sequence Homology, Amino Acid KW - Protein Structure, Tertiary KW - Mutation KW - Protein Conformation KW - Arginine -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68719290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=A+single+pair+of+acidic+residues+in+the+kinase+major+groove+mediates+strong+substrate+preference+for+P-2+or+P-5+arginine+in+the+AGC%2C+CAMK%2C+and+STE+kinase+families.&rft.au=Zhu%2C+Guozhi%3BFujii%2C+Koichi%3BLiu%2C+Yin%3BCodrea%2C+Vlad%3BHerrero%2C+Juan%3BShaw%2C+Stephen&rft.aulast=Zhu&rft.aufirst=Guozhi&rft.date=2005-10-28&rft.volume=280&rft.issue=43&rft.spage=36372&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-04 N1 - Date created - 2005-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lysophosphatidic acid and endothelin-induced proliferation of ovarian cancer cell lines is mitigated by neutralization of granulin-epithelin precursor (GEP), a prosurvival factor for ovarian cancer. AN - 68736427; 16044162 AB - Granulin-epithelin precursor (GEP/progranulin) is an autocrine growth factor for ovarian cancer. We examined the production and function of GEP and report that: (1) GEP production is regulated by endothelin (ET-1), lysophosphatidic acid (LPA), and cAMP; (2) cAMP signals GEP production through exchange protein activated by cAMP (EPAC); (3) ET-1 and cAMP/EPAC induce GEP through ERK1/2; and (4) neutralization of GEP results in apoptosis. Exposure of HEY-A8 and OVCAR3 ovarian cancer cells to LPA and ET-1 yielded GEP production and secretion in a dose- and time-dependent fashion; neither stimulated significant concentrations of cAMP directly. Stimulation of cAMP production with pertussis and cholera toxin, or forskolin induced GEP in a PKA-independent fashion. EPAC, an intracellular cAMP receptor, is activated specifically by the cAMP analog, 8-CPT-2'-O-Me-cAMP (8-CPT); 8-CPT treatment stimulated GEP production and secretion. The MEK inhibitor, U0126, abrogated GEP production in response to ET-1 and 8-CPT, confirming involvement of MAPK. A partial inhibition of basal and stimulated GEP production was observed when cells were treated with a internal calcium chelator, BAPTA. Neutralizing anti-GEP antibody reversed basal as well as LPA, ET-1 and 8-CPT-induced ovarian cancer cell growth and induced apoptosis as demonstrated by caspase-3 and PARP cleavage, DNA fragmentation, and nuclear condensation. These results indicate that GEP is a growth and survival factor for ovarian cancer, induced by LPA and ET-1 and cAMP/EPAC through ERK1/2. JF - Oncogene AU - Kamrava, Mitchell AU - Simpkins, Fiona AU - Alejandro, Emilyn AU - Michener, Chad AU - Meltzer, Elizabeth AU - Kohn, Elise C AD - Howard Hughes Medical Institute/National Institutes of Health Research Scholars Program, National Institutes of Health, Bethesda, MD, USA. Y1 - 2005/10/27/ PY - 2005 DA - 2005 Oct 27 SP - 7084 EP - 7093 VL - 24 IS - 47 SN - 0950-9232, 0950-9232 KW - Adjuvants, Immunologic KW - 0 KW - Chelating Agents KW - Endothelins KW - Guanine Nucleotide Exchange Factors KW - Intercellular Signaling Peptides and Proteins KW - Lysophospholipids KW - RAPGEF3 protein, human KW - granulin precursor protein KW - 134710-81-9 KW - Colforsin KW - 1F7A44V6OU KW - Egtazic Acid KW - 526U7A2651 KW - Cholera Toxin KW - 9012-63-9 KW - Cyclic AMP KW - E0399OZS9N KW - Poly(ADP-ribose) Polymerases KW - EC 2.4.2.30 KW - Pertussis Toxin KW - EC 2.4.2.31 KW - Cyclic AMP-Dependent Protein Kinases KW - EC 2.7.11.11 KW - Mitogen-Activated Protein Kinase 1 KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinase 3 KW - MAP Kinase Kinase 1 KW - EC 2.7.12.2 KW - CASP3 protein, human KW - EC 3.4.22.- KW - Caspase 3 KW - Caspases KW - 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid KW - K22DDW77C0 KW - lysophosphatidic acid KW - PG6M3969SG KW - Index Medicus KW - Cyclic AMP-Dependent Protein Kinases -- metabolism KW - Egtazic Acid -- analogs & derivatives KW - Blotting, Northern KW - Cell Nucleus -- metabolism KW - Humans KW - Guanine Nucleotide Exchange Factors -- metabolism KW - Cholera Toxin -- pharmacology KW - Pertussis Toxin -- pharmacology KW - Cell Nucleus -- drug effects KW - Poly(ADP-ribose) Polymerases -- metabolism KW - Caspases -- metabolism KW - Mitogen-Activated Protein Kinase 3 -- metabolism KW - Chelating Agents -- pharmacology KW - Blotting, Western KW - Colforsin -- pharmacology KW - Tumor Cells, Cultured KW - Mitogen-Activated Protein Kinase 1 -- metabolism KW - Cyclic AMP -- metabolism KW - Adjuvants, Immunologic -- pharmacology KW - MAP Kinase Kinase 1 -- metabolism KW - Egtazic Acid -- pharmacology KW - Female KW - Cell Proliferation -- drug effects KW - Ovarian Neoplasms -- metabolism KW - Endothelins -- pharmacology KW - Intercellular Signaling Peptides and Proteins -- immunology KW - Ovarian Neoplasms -- pathology KW - Apoptosis -- drug effects KW - Lysophospholipids -- pharmacology KW - Intercellular Signaling Peptides and Proteins -- chemistry KW - Intercellular Signaling Peptides and Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68736427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Lysophosphatidic+acid+and+endothelin-induced+proliferation+of+ovarian+cancer+cell+lines+is+mitigated+by+neutralization+of+granulin-epithelin+precursor+%28GEP%29%2C+a+prosurvival+factor+for+ovarian+cancer.&rft.au=Kamrava%2C+Mitchell%3BSimpkins%2C+Fiona%3BAlejandro%2C+Emilyn%3BMichener%2C+Chad%3BMeltzer%2C+Elizabeth%3BKohn%2C+Elise+C&rft.aulast=Kamrava&rft.aufirst=Mitchell&rft.date=2005-10-27&rft.volume=24&rft.issue=47&rft.spage=7084&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-15 N1 - Date created - 2005-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - p53, Senescence and Cancer T2 - 2005 Symposium on Stem Cells, Senescence and Cancer (D5) AN - 40006472; 3987884 JF - 2005 Symposium on Stem Cells, Senescence and Cancer (D5) AU - Harris, Curtis C Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - p53 protein KW - Cancer KW - Senescence KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40006472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Symposium+on+Stem+Cells%2C+Senescence+and+Cancer+%28D5%29&rft.atitle=p53%2C+Senescence+and+Cancer&rft.au=Harris%2C+Curtis+C&rft.aulast=Harris&rft.aufirst=Curtis&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Symposium+on+Stem+Cells%2C+Senescence+and+Cancer+%28D5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=764 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Histopathological Improvement of Severe Acute Graft Versus Host Disease of the Gut with Unrelated Mesenchymal Stem Cells T2 - 2005 Symposium on Stem Cells, Senescence and Cancer (D5) AN - 40003874; 3987860 JF - 2005 Symposium on Stem Cells, Senescence and Cancer (D5) AU - Balakumaran, Arun Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Hosts KW - Stem cells KW - Digestive tract KW - Mesenchyme KW - Histopathology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40003874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Symposium+on+Stem+Cells%2C+Senescence+and+Cancer+%28D5%29&rft.atitle=Histopathological+Improvement+of+Severe+Acute+Graft+Versus+Host+Disease+of+the+Gut+with+Unrelated+Mesenchymal+Stem+Cells&rft.au=Balakumaran%2C+Arun&rft.aulast=Balakumaran&rft.aufirst=Arun&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Symposium+on+Stem+Cells%2C+Senescence+and+Cancer+%28D5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=764 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic and Evolutionary Analysis of the ABCC6 Gene and Pseudoxanthoma Elasticum (PXE) T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39866328; 4038645 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Lou, H AU - Bergeron, J AU - Thomas, L AU - Terry, S F AU - Terry, P F AU - Dean, M Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - ABCC6 gene KW - Evolution KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39866328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Genetic+and+Evolutionary+Analysis+of+the+ABCC6+Gene+and+Pseudoxanthoma+Elasticum+%28PXE%29&rft.au=Lou%2C+H%3BBergeron%2C+J%3BThomas%2C+L%3BTerry%2C+S+F%3BTerry%2C+P+F%3BDean%2C+M&rft.aulast=Lou&rft.aufirst=H&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evidence for Constraint in Telomere Stability Genes T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39836102; 4037655 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Savage, S A AU - Yeager, M AU - Liao, J AU - Chanock, S J Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Telomeres KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39836102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Evidence+for+Constraint+in+Telomere+Stability+Genes&rft.au=Savage%2C+S+A%3BYeager%2C+M%3BLiao%2C+J%3BChanock%2C+S+J&rft.aulast=Savage&rft.aufirst=S&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Physicians' Beliefs about the Role of Genetics in Health Differences and the Importance of Race/Ethnicity and Gender in Clinical Decision Making T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39835624; 4037545 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Warshauer-Baker, E AU - Bonham, V L AU - Jenkins, J AU - Stevens, N AU - Page, Z AU - Odunlami, A AU - McBride, C Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Ethnic groups KW - Subpopulations KW - Races KW - Sex KW - Genetics KW - Decision making KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39835624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Physicians%27+Beliefs+about+the+Role+of+Genetics+in+Health+Differences+and+the+Importance+of+Race%2FEthnicity+and+Gender+in+Clinical+Decision+Making&rft.au=Warshauer-Baker%2C+E%3BBonham%2C+V+L%3BJenkins%2C+J%3BStevens%2C+N%3BPage%2C+Z%3BOdunlami%2C+A%3BMcBride%2C+C&rft.aulast=Warshauer-Baker&rft.aufirst=E&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DOCK9, a Candidate Bipolar Disorder Susceptibility Gene on Chromosome 13@Q32.3 T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39817338; 4038275 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Detera-Wadleigh, S AU - Liu, C AU - Badner, J AU - Corona, W AU - Akula, N AU - Cardona, I AU - Kundu, M AU - Steele, C.J.M. AU - Maheshwari, M AU - Bonner, T AU - Gibbs, R AU - Gershon, E AU - Mcmahon, F Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Chromosome 13 KW - Chromosomes KW - Bipolar disorder KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39817338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=DOCK9%2C+a+Candidate+Bipolar+Disorder+Susceptibility+Gene+on+Chromosome+13%40Q32.3&rft.au=Detera-Wadleigh%2C+S%3BLiu%2C+C%3BBadner%2C+J%3BCorona%2C+W%3BAkula%2C+N%3BCardona%2C+I%3BKundu%2C+M%3BSteele%2C+C.J.M.%3BMaheshwari%2C+M%3BBonner%2C+T%3BGibbs%2C+R%3BGershon%2C+E%3BMcmahon%2C+F&rft.aulast=Detera-Wadleigh&rft.aufirst=S&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PRKAR1A Mutations Leading to Carney Complex, PPNAD and Related Disorders: Analysis of the Largest Database to Date, Identification of Large Gene Rearrangments and Other Novel Disease-Causing Alterations, and Functional Characterization of Expressed Mutants T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39807555; 4036397 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Horvath, A AU - Boikos, S AU - Weinberg, F AU - Meoli, E AU - Stergiopoulos, S AU - Bei, T AU - Matyakhina, L AU - Bossis, I AU - Stratakis, C Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Mutants KW - Mutation KW - Carney complex KW - Databases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39807555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=PRKAR1A+Mutations+Leading+to+Carney+Complex%2C+PPNAD+and+Related+Disorders%3A+Analysis+of+the+Largest+Database+to+Date%2C+Identification+of+Large+Gene+Rearrangments+and+Other+Novel+Disease-Causing+Alterations%2C+and+Functional+Characterization+of+Expressed+Mutants&rft.au=Horvath%2C+A%3BBoikos%2C+S%3BWeinberg%2C+F%3BMeoli%2C+E%3BStergiopoulos%2C+S%3BBei%2C+T%3BMatyakhina%2C+L%3BBossis%2C+I%3BStratakis%2C+C&rft.aulast=Horvath&rft.aufirst=A&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Design of a National Resource for Gene Discovery in Parkinsons Disease T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39804969; 4038096 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Horsford, D J AU - Keen, J AU - Beck, J AU - Murphy, D AU - Scudder, Q AU - Royds, C AU - Gwinn-Hardy, K AU - Rich, S Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Neurodegenerative diseases KW - Parkinson's disease KW - Movement disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39804969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Design+of+a+National+Resource+for+Gene+Discovery+in+Parkinsons+Disease&rft.au=Horsford%2C+D+J%3BKeen%2C+J%3BBeck%2C+J%3BMurphy%2C+D%3BScudder%2C+Q%3BRoyds%2C+C%3BGwinn-Hardy%2C+K%3BRich%2C+S&rft.aulast=Horsford&rft.aufirst=D&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Familial Autoimmune Myasthenia Gravis - Results of a Genome-Wide Scan T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39772922; 4038687 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Knight, M A AU - Landoure, G AU - Taye, A A AU - Fischbeck, K H Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Myasthenia gravis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39772922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Familial+Autoimmune+Myasthenia+Gravis+-+Results+of+a+Genome-Wide+Scan&rft.au=Knight%2C+M+A%3BLandoure%2C+G%3BTaye%2C+A+A%3BFischbeck%2C+K+H&rft.aulast=Knight&rft.aufirst=M&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Consortium for Osteogenesis Imperfecta Mutations: Lethal Regions in the Helical Portion of Type I Collagen Chains Align with Collagen Binding Sites for Integrin and Proteoglycans T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39772019; 4038544 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Marini, J AU - Forlino, A AU - Cabral, W AU - Barnes, A AU - San Antonio, J AU - Milgrom, S AU - Hyland, J AU - Korkko, J AU - Prockop, D AU - DePaepe, A AU - Coucke, P AU - Glorieux, F AU - Roughley, P AU - Lund, A AU - Kuurila, K AU - Cohn, D AU - Krakow, D AU - Mottes, M AU - Dalgleish, R AU - Byers, P Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Collagen (type I) KW - Mutation KW - Osteogenesis imperfecta KW - Integrins KW - Proteoglycans KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39772019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Consortium+for+Osteogenesis+Imperfecta+Mutations%3A+Lethal+Regions+in+the+Helical+Portion+of+Type+I+Collagen+Chains+Align+with+Collagen+Binding+Sites+for+Integrin+and+Proteoglycans&rft.au=Marini%2C+J%3BForlino%2C+A%3BCabral%2C+W%3BBarnes%2C+A%3BSan+Antonio%2C+J%3BMilgrom%2C+S%3BHyland%2C+J%3BKorkko%2C+J%3BProckop%2C+D%3BDePaepe%2C+A%3BCoucke%2C+P%3BGlorieux%2C+F%3BRoughley%2C+P%3BLund%2C+A%3BKuurila%2C+K%3BCohn%2C+D%3BKrakow%2C+D%3BMottes%2C+M%3BDalgleish%2C+R%3BByers%2C+P&rft.aulast=Marini&rft.aufirst=J&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Animal Study of Direct Central Nervous System Administration of Copper Histidine: Prelude to Clinical Trial in Menkes Disease T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39771241; 4038134 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Lem, K AU - Brinster, L R AU - Tjurmina, O AU - Kaler, S G Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Menkes disease KW - Clinical trials KW - Histidine KW - Copper KW - Central nervous system KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39771241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Animal+Study+of+Direct+Central+Nervous+System+Administration+of+Copper+Histidine%3A+Prelude+to+Clinical+Trial+in+Menkes+Disease&rft.au=Lem%2C+K%3BBrinster%2C+L+R%3BTjurmina%2C+O%3BKaler%2C+S+G&rft.aulast=Lem&rft.aufirst=K&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Autosomal Dominant Inheritance of Stuttering in a West African Population T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39770833; 4038036 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Levis, B AU - Lukong, J AU - Mundorff, J AU - Drayna, D Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Africa KW - Heredity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39770833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Autosomal+Dominant+Inheritance+of+Stuttering+in+a+West+African+Population&rft.au=Levis%2C+B%3BLukong%2C+J%3BMundorff%2C+J%3BDrayna%2C+D&rft.aulast=Levis&rft.aufirst=B&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NIEHS Environmental Genome Project: Functional Significance of Environmentally-Responsive Genotypes for Human Disease. T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39762539; 4037417 JF - 55th Annual Meeting of the American Society of Human Genetics AU - McAllister, K AU - Tyson, F AU - Maull, L AU - Gray, K AU - Srinivasan, S AU - Reinlib, L AU - Collman, G Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Genomes KW - Genotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39762539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=NIEHS+Environmental+Genome+Project%3A+Functional+Significance+of+Environmentally-Responsive+Genotypes+for+Human+Disease.&rft.au=McAllister%2C+K%3BTyson%2C+F%3BMaull%2C+L%3BGray%2C+K%3BSrinivasan%2C+S%3BReinlib%2C+L%3BCollman%2C+G&rft.aulast=McAllister&rft.aufirst=K&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NCBI Entrez Phenotype Resources. T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39762509; 4037415 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Mailman, M D AU - Sherry, S T AU - Maglott, D R Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39762509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=NCBI+Entrez+Phenotype+Resources.&rft.au=Mailman%2C+M+D%3BSherry%2C+S+T%3BMaglott%2C+D+R&rft.aulast=Mailman&rft.aufirst=M&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using Hispanic Genetic Diversity to Infer the Haplotype Structure of Native Americans T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39761654; 4037632 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Tarazona-Santos, E AU - Yeager, M AU - Staats, B AU - Welch, R AU - Burdette, L AU - Packer, B AU - Chanock, S Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Ethnic groups KW - Haplotypes KW - Genetic diversity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39761654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Using+Hispanic+Genetic+Diversity+to+Infer+the+Haplotype+Structure+of+Native+Americans&rft.au=Tarazona-Santos%2C+E%3BYeager%2C+M%3BStaats%2C+B%3BWelch%2C+R%3BBurdette%2C+L%3BPacker%2C+B%3BChanock%2C+S&rft.aulast=Tarazona-Santos&rft.aufirst=E&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Use of Nude and Identifiable Photographs in Medical Genetics Textbooks: Ethical Considerations T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39761016; 4037549 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Burchett, M E AU - Gustafson, A L AU - Francomano, C A AU - McDonnell, N B Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Photographs KW - Ethics KW - Genetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39761016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=The+Use+of+Nude+and+Identifiable+Photographs+in+Medical+Genetics+Textbooks%3A+Ethical+Considerations&rft.au=Burchett%2C+M+E%3BGustafson%2C+A+L%3BFrancomano%2C+C+A%3BMcDonnell%2C+N+B&rft.aulast=Burchett&rft.aufirst=M&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comprehensive Analysis of Sequence Variation in the Peptidyl Arginine Deiminase Type IV Gene (PADI4) Suggests a Novel Intronic Variant is Associated with Rheumatoid Arthritis in the North American Caucasian Population T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39756277; 4038336 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Remmers, E AU - Plenge, R AU - Le, J. AU - Lee, A AU - Aksentijevich, I AU - Kastner, D AU - Gregersen, P Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - North America KW - Rheumatoid arthritis KW - Arginine deiminase KW - Arginine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39756277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Comprehensive+Analysis+of+Sequence+Variation+in+the+Peptidyl+Arginine+Deiminase+Type+IV+Gene+%28PADI4%29+Suggests+a+Novel+Intronic+Variant+is+Associated+with+Rheumatoid+Arthritis+in+the+North+American+Caucasian+Population&rft.au=Remmers%2C+E%3BPlenge%2C+R%3BLe%2C+J.%3BLee%2C+A%3BAksentijevich%2C+I%3BKastner%2C+D%3BGregersen%2C+P&rft.aulast=Remmers&rft.aufirst=E&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association of SNP Haplotypes of Interleukin-1 Beta with Persistent Sciatica Following Lumbar Diskectomy T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39756055; 4038468 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Wu, T. AU - Kingman, A AU - Bollettino, A AU - Hipp, H AU - Scully, M AU - Belfer, I AU - Atlas, S AU - Buzas, B AU - McKnight, C AU - Keller, R AU - Goldman, D AU - Max, M Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Haplotypes KW - Interleukin 1 KW - Single-nucleotide polymorphism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39756055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Association+of+SNP+Haplotypes+of+Interleukin-1+Beta+with+Persistent+Sciatica+Following+Lumbar+Diskectomy&rft.au=Wu%2C+T.%3BKingman%2C+A%3BBollettino%2C+A%3BHipp%2C+H%3BScully%2C+M%3BBelfer%2C+I%3BAtlas%2C+S%3BBuzas%2C+B%3BMcKnight%2C+C%3BKeller%2C+R%3BGoldman%2C+D%3BMax%2C+M&rft.aulast=Wu&rft.aufirst=T.&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Arg16Gly Polymorphism in Beta2-Adrenoreceptor is Associated with Severe Obesity in Pima Indian Women T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39755494; 4037929 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Guo, T AU - Muller, Y AU - Ma, L. AU - Valenzuela, R AU - Hanson, R AU - Kobes, S AU - Bogardus, C AU - Baier, L Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Obesity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39755494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=The+Arg16Gly+Polymorphism+in+Beta2-Adrenoreceptor+is+Associated+with+Severe+Obesity+in+Pima+Indian+Women&rft.au=Guo%2C+T%3BMuller%2C+Y%3BMa%2C+L.%3BValenzuela%2C+R%3BHanson%2C+R%3BKobes%2C+S%3BBogardus%2C+C%3BBaier%2C+L&rft.aulast=Guo&rft.aufirst=T&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Susceptibility to Neonatal-Onset Multisystem Inflammatory Disease (NOMID/CINCA): Novel CIAS1 Mutations and Genomic Strategies to Resolve Locus Heterogeneity T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39754108; 4038740 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Aksentijevich, I AU - Balow Jr, J AU - Jones, J AU - Dailey, N AU - Canna, S AU - Remmers, E F AU - Goldbach-Mansky, R AU - Kastner, D L Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Inflammatory diseases KW - Mutation KW - Genomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39754108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Genetic+Susceptibility+to+Neonatal-Onset+Multisystem+Inflammatory+Disease+%28NOMID%2FCINCA%29%3A+Novel+CIAS1+Mutations+and+Genomic+Strategies+to+Resolve+Locus+Heterogeneity&rft.au=Aksentijevich%2C+I%3BBalow+Jr%2C+J%3BJones%2C+J%3BDailey%2C+N%3BCanna%2C+S%3BRemmers%2C+E+F%3BGoldbach-Mansky%2C+R%3BKastner%2C+D+L&rft.aulast=Aksentijevich&rft.aufirst=I&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Caspase-1-Mediated Cleavage of Pyrin, the Familial Mediterranean Fever Protein, Activates NF-? T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39754053; 4038739 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Chae, B J AU - Richard, K AU - Wood, G AU - Jaffe, H AU - Gumucio, D AU - Shoham, N AU - Kastner, D Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Mediterranean KW - Pyrin KW - Fever KW - Mediterranean region KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39754053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Caspase-1-Mediated+Cleavage+of+Pyrin%2C+the+Familial+Mediterranean+Fever+Protein%2C+Activates+NF-%3F&rft.au=Chae%2C+B+J%3BRichard%2C+K%3BWood%2C+G%3BJaffe%2C+H%3BGumucio%2C+D%3BShoham%2C+N%3BKastner%2C+D&rft.aulast=Chae&rft.aufirst=B&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A VCAM1 Promoter Mutation that Affects Transcription Factor Binding is Observed with Increased Prevalence in Adults with Sickle Cell Anemia T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39752613; 4038667 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Taylor, J G AU - Chen, R A AU - Haudenschild, C AU - Ragavachari, N AU - Bernig, T AU - Garcia-Rossi, D AU - Hutchinson, A AU - Hoppe, C AU - Gladwin, M T AU - Chanock, S J Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Mutation KW - Sickle cell disease KW - Promoters KW - Transcription factors KW - Anemia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39752613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=A+VCAM1+Promoter+Mutation+that+Affects+Transcription+Factor+Binding+is+Observed+with+Increased+Prevalence+in+Adults+with+Sickle+Cell+Anemia&rft.au=Taylor%2C+J+G%3BChen%2C+R+A%3BHaudenschild%2C+C%3BRagavachari%2C+N%3BBernig%2C+T%3BGarcia-Rossi%2C+D%3BHutchinson%2C+A%3BHoppe%2C+C%3BGladwin%2C+M+T%3BChanock%2C+S+J&rft.aulast=Taylor&rft.aufirst=J&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Possible Founder Mutation for Juvenile Hyaline Fibromatosis in Brazil T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39746326; 4037579 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Ramaswami, M D AU - Hart, P S AU - Acevedo, A C AU - Pallos, D AU - Hart, T C Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Brazil KW - Mutation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39746326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Possible+Founder+Mutation+for+Juvenile+Hyaline+Fibromatosis+in+Brazil&rft.au=Ramaswami%2C+M+D%3BHart%2C+P+S%3BAcevedo%2C+A+C%3BPallos%2C+D%3BHart%2C+T+C&rft.aulast=Ramaswami&rft.aufirst=M&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Mouse Inner Ear MPSS Libraries to Select for Rare and Novel Expressed Genes. T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39746072; 4037308 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Peters, L M AU - Belyantseva, I A AU - Battey, J F AU - Friedman, T B AU - Morell, R J Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Inner ear KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39746072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Analysis+of+Mouse+Inner+Ear+MPSS+Libraries+to+Select+for+Rare+and+Novel+Expressed+Genes.&rft.au=Peters%2C+L+M%3BBelyantseva%2C+I+A%3BBattey%2C+J+F%3BFriedman%2C+T+B%3BMorell%2C+R+J&rft.aulast=Peters&rft.aufirst=L&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evolution and Distribution of Haplotypes in the Complement Factor H (HF1/CFH) Gene that Predispose to Age-Related Macular Degeneration T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39744596; 4037693 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Dean, M AU - Gold, B AU - Bergeron, J AU - Anderson, D H AU - Johnson, L V AU - Allikmets, R AU - Hageman, G Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Evolutionary genetics KW - Haplotypes KW - Macular degeneration KW - Complement factor H KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39744596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Evolution+and+Distribution+of+Haplotypes+in+the+Complement+Factor+H+%28HF1%2FCFH%29+Gene+that+Predispose+to+Age-Related+Macular+Degeneration&rft.au=Dean%2C+M%3BGold%2C+B%3BBergeron%2C+J%3BAnderson%2C+D+H%3BJohnson%2C+L+V%3BAllikmets%2C+R%3BHageman%2C+G&rft.aulast=Dean&rft.aufirst=M&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recruitment to a Familial Cancer Study: Balancing Privacy Protection and Research Quality T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39744019; 4037543 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Slutsman, J AU - Graubard, B AU - Garceau, A AU - Willis, G AU - Wideroff, L Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Recruitment KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39744019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Recruitment+to+a+Familial+Cancer+Study%3A+Balancing+Privacy+Protection+and+Research+Quality&rft.au=Slutsman%2C+J%3BGraubard%2C+B%3BGarceau%2C+A%3BWillis%2C+G%3BWideroff%2C+L&rft.aulast=Slutsman&rft.aufirst=J&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adipokine Gene Variants Associated with Type 2 Diabetes in the Aboriginal Sakha (Yakut) Population of Eastern Siberia T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39743751; 4038322 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Sambuughin, N AU - Platonov, F AU - Ignatiev, P AU - Osakovskiy, V AU - Sivtseva, T AU - De Bantel, A AU - Shatunov, A AU - Krivoshapkin, V AU - Goldfarb, L Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Russia, Siberia KW - Russia, Sakha KW - Diabetes mellitus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39743751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Adipokine+Gene+Variants+Associated+with+Type+2+Diabetes+in+the+Aboriginal+Sakha+%28Yakut%29+Population+of+Eastern+Siberia&rft.au=Sambuughin%2C+N%3BPlatonov%2C+F%3BIgnatiev%2C+P%3BOsakovskiy%2C+V%3BSivtseva%2C+T%3BDe+Bantel%2C+A%3BShatunov%2C+A%3BKrivoshapkin%2C+V%3BGoldfarb%2C+L&rft.aulast=Sambuughin&rft.aufirst=N&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Polymorphisms in Catechol O-Methyltransferase Gene (COMT) Affect Acute Post-Surgical Pain in Humans T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39743228; 4038187 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Kim, H AU - Mittal, D AU - Brahim, J AU - Rowan, J AU - Dionne, R Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Pain KW - Gene polymorphism KW - Catechol O-methyltransferase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39743228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Genetic+Polymorphisms+in+Catechol+O-Methyltransferase+Gene+%28COMT%29+Affect+Acute+Post-Surgical+Pain+in+Humans&rft.au=Kim%2C+H%3BMittal%2C+D%3BBrahim%2C+J%3BRowan%2C+J%3BDionne%2C+R&rft.aulast=Kim&rft.aufirst=H&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evidence for Linkage of Serum Alkaline Phosphatase Levels: A Genome-Wide Scan in the Framingham Offspring Study T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39740560; 4037876 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Lin, J-P AU - Cupples, A AU - O'Donnell, C Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Progeny KW - Phosphatase KW - Alkaline phosphatase KW - Offspring KW - Serum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39740560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Evidence+for+Linkage+of+Serum+Alkaline+Phosphatase+Levels%3A+A+Genome-Wide+Scan+in+the+Framingham+Offspring+Study&rft.au=Lin%2C+J-P%3BCupples%2C+A%3BO%27Donnell%2C+C&rft.aulast=Lin&rft.aufirst=J-P&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Haplotype Diversity and Population Histories in the CEPH Human Genome Diversity Panel Based Upon Variation in Four Cytochrome P450 Genes and COMT T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39740422; 4037679 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Modi, W AU - Sicotte, H AU - Garcia-Ross, D AU - Yeager-Jeffery, M AU - Welch, R AU - Burdette, L AU - Cann, H AU - Thomas, G AU - Chanock, S Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Haplotypes KW - Genomes KW - Genetic diversity KW - Historical account KW - Cytochrome P450 KW - Population genetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39740422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Haplotype+Diversity+and+Population+Histories+in+the+CEPH+Human+Genome+Diversity+Panel+Based+Upon+Variation+in+Four+Cytochrome+P450+Genes+and+COMT&rft.au=Modi%2C+W%3BSicotte%2C+H%3BGarcia-Ross%2C+D%3BYeager-Jeffery%2C+M%3BWelch%2C+R%3BBurdette%2C+L%3BCann%2C+H%3BThomas%2C+G%3BChanock%2C+S&rft.aulast=Modi&rft.aufirst=W&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of Glycine Substitutions in the Amino End of Type I Collagen by Biochemical Screening of Fibroblast Collagen Requires Supplementation by Direct Sequencing for Osteogenesis Imperfecta Probands. T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39739498; 4037197 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Cabral, W A AU - Milgrom, S AU - Moriarty, E AU - Marini, J C Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Collagen (type I) KW - Supplementation KW - Glycine KW - Osteogenesis imperfecta KW - Fibroblasts KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39739498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Detection+of+Glycine+Substitutions+in+the+Amino+End+of+Type+I+Collagen+by+Biochemical+Screening+of+Fibroblast+Collagen+Requires+Supplementation+by+Direct+Sequencing+for+Osteogenesis+Imperfecta+Probands.&rft.au=Cabral%2C+W+A%3BMilgrom%2C+S%3BMoriarty%2C+E%3BMarini%2C+J+C&rft.aulast=Cabral&rft.aufirst=W&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Morphologic Characteristics in Hemizygous Fabry Disease Patients T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39738357; 4036934 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Ries, M AU - Moore, D F AU - Robinson, C AU - Tifft, C AU - Rosenbaum, K AU - Brady, R O AU - Schiffmann, R AU - Krasnewich, D Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Fabry's disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39738357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Morphologic+Characteristics+in+Hemizygous+Fabry+Disease+Patients&rft.au=Ries%2C+M%3BMoore%2C+D+F%3BRobinson%2C+C%3BTifft%2C+C%3BRosenbaum%2C+K%3BBrady%2C+R+O%3BSchiffmann%2C+R%3BKrasnewich%2C+D&rft.aulast=Ries&rft.aufirst=M&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Late Evening Settling and Early Morning Sleep Maintenance Differentiate the Sleep Patterns of Adolescents and Younger Children with Smith-Magenis Syndrome (SMS) T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39737988; 4036820 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Duncan, W C AU - Morse, R S AU - Krasnewich, D AU - Smith, A.C.M. Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Symptoms KW - Children KW - Adolescents KW - Sleep KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39737988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Late+Evening+Settling+and+Early+Morning+Sleep+Maintenance+Differentiate+the+Sleep+Patterns+of+Adolescents+and+Younger+Children+with+Smith-Magenis+Syndrome+%28SMS%29&rft.au=Duncan%2C+W+C%3BMorse%2C+R+S%3BKrasnewich%2C+D%3BSmith%2C+A.C.M.&rft.aulast=Duncan&rft.aufirst=W&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FH Mutation Analysis, Enzyme Activity, Protein Modeling and Early Functional Study in Hereditary Leiomyomatosis and Renal Cell Cancer T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39736457; 4036536 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Pithukpakorn, M AU - Wei, M H AU - Toure, O AU - Glenn, G M AU - Middelton, L AU - Merino, M AU - Zbar, B AU - Neckers, L AU - Linehan, W M AU - Toro, J R Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Enzymatic activity KW - Kidneys KW - Mutation KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39736457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=FH+Mutation+Analysis%2C+Enzyme+Activity%2C+Protein+Modeling+and+Early+Functional+Study+in+Hereditary+Leiomyomatosis+and+Renal+Cell+Cancer&rft.au=Pithukpakorn%2C+M%3BWei%2C+M+H%3BToure%2C+O%3BGlenn%2C+G+M%3BMiddelton%2C+L%3BMerino%2C+M%3BZbar%2C+B%3BNeckers%2C+L%3BLinehan%2C+W+M%3BToro%2C+J+R&rft.aulast=Pithukpakorn&rft.aufirst=M&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Twin Study Heritability Estimates of Central Auditory Processing Functions T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39736000; 4038385 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Drayna, D AU - Brewer, C AU - Snieder, H AU - Zalewski, C AU - Friedman, T AU - Morell, R Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Information processing KW - Twins KW - Heritability KW - Auditory system KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39736000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Twin+Study+Heritability+Estimates+of+Central+Auditory+Processing+Functions&rft.au=Drayna%2C+D%3BBrewer%2C+C%3BSnieder%2C+H%3BZalewski%2C+C%3BFriedman%2C+T%3BMorell%2C+R&rft.aulast=Drayna&rft.aufirst=D&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SNPdetector: A Software Tool for Sensitive and Accurate Detection of Single Nucleotide Polymorphisms and Mutations in Fluorescence-Based Resequencing T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39733364; 4037578 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Zhang, J AU - Wheeler, D AU - Yakub, I AU - Wei, S AU - Sood, R AU - Rowe, W AU - Liu, P AU - Gibbs, R AU - Buetow, K Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Nucleotides KW - Mutation KW - Single-nucleotide polymorphism KW - Computer programs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39733364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=SNPdetector%3A+A+Software+Tool+for+Sensitive+and+Accurate+Detection+of+Single+Nucleotide+Polymorphisms+and+Mutations+in+Fluorescence-Based+Resequencing&rft.au=Zhang%2C+J%3BWheeler%2C+D%3BYakub%2C+I%3BWei%2C+S%3BSood%2C+R%3BRowe%2C+W%3BLiu%2C+P%3BGibbs%2C+R%3BBuetow%2C+K&rft.aulast=Zhang&rft.aufirst=J&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Mutation Spectrum of MYO7A Associated with Usher Syndrome Type 1 and Evidence for the Existence of DFNB2 T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39729433; 4038502 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Riazuddin, S AU - Nazli, S AU - Sheikh, R S AU - Khan, S N AU - Sabir, F AU - Javid, F T AU - Wilcox, E R AU - Ahmed, Z A AU - Friedman, T B Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Symptoms KW - Mutation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39729433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=A+Mutation+Spectrum+of+MYO7A+Associated+with+Usher+Syndrome+Type+1+and+Evidence+for+the+Existence+of+DFNB2&rft.au=Riazuddin%2C+S%3BNazli%2C+S%3BSheikh%2C+R+S%3BKhan%2C+S+N%3BSabir%2C+F%3BJavid%2C+F+T%3BWilcox%2C+E+R%3BAhmed%2C+Z+A%3BFriedman%2C+T+B&rft.aulast=Riazuddin&rft.aufirst=S&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Glucocerebrosidase Alterations E326K and T369M in Subjects with and without Parkinsonism T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39728553; 4038325 DE: JF - 55th Annual Meeting of the American Society of Human Genetics AU - Eblan, M J AU - Hruska, K AU - Nguyen, J AU - Walker, J AU - Sidransky, E Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39728553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Glucocerebrosidase+Alterations+E326K+and+T369M+in+Subjects+with+and+without+Parkinsonism&rft.au=Eblan%2C+M+J%3BHruska%2C+K%3BNguyen%2C+J%3BWalker%2C+J%3BSidransky%2C+E&rft.aulast=Eblan&rft.aufirst=M&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genome-Wide Scan for Familial Cutaneous Malignant Melanoma (CMM) Susceptibility Loci in A Northeastern Italian Population T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39727456; 4037819 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Kerstann, K F AU - Steighner, R AU - Ter-Minassian, M AU - Calista, D AU - Minghetti, P AU - Landi, G AU - Goldstein, A M AU - Landi, M T Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Melanoma KW - Population genetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39727456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Genome-Wide+Scan+for+Familial+Cutaneous+Malignant+Melanoma+%28CMM%29+Susceptibility+Loci+in+A+Northeastern+Italian+Population&rft.au=Kerstann%2C+K+F%3BSteighner%2C+R%3BTer-Minassian%2C+M%3BCalista%2C+D%3BMinghetti%2C+P%3BLandi%2C+G%3BGoldstein%2C+A+M%3BLandi%2C+M+T&rft.aulast=Kerstann&rft.aufirst=K&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of Long-Term Treatment for Hypertension Using Human Skin Gene Therapy to Deliver Systemic Atrial Natriuretic Peptide (ANP) T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39723701; 4038292 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Therrien, J-P AU - Tock, C L AU - Ohyama, M AU - Voge, J C Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Gene therapy KW - Atrial natriuretic peptide KW - Peptides KW - Hypertension KW - Skin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39723701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Development+of+Long-Term+Treatment+for+Hypertension+Using+Human+Skin+Gene+Therapy+to+Deliver+Systemic+Atrial+Natriuretic+Peptide+%28ANP%29&rft.au=Therrien%2C+J-P%3BTock%2C+C+L%3BOhyama%2C+M%3BVoge%2C+J+C&rft.aulast=Therrien&rft.aufirst=J-P&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fine Mapping of a Putative Type II Diabetes Susceptibility Gene on 1Q in Native American Pimas T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39723268; 4038148 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Singer, J M AU - Ossowski, V AU - Mccarthy, M I AU - Deloukas, P AU - Zeggini, E AU - Rayner, W AU - Bogardus, C AU - Prochazka, M Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Ethnic groups KW - Chromosome 1 KW - Diabetes mellitus KW - Gene mapping KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39723268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Fine+Mapping+of+a+Putative+Type+II+Diabetes+Susceptibility+Gene+on+1Q+in+Native+American+Pimas&rft.au=Singer%2C+J+M%3BOssowski%2C+V%3BMccarthy%2C+M+I%3BDeloukas%2C+P%3BZeggini%2C+E%3BRayner%2C+W%3BBogardus%2C+C%3BProchazka%2C+M&rft.aulast=Singer&rft.aufirst=J&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dysfunction of Endocytic and Autophagic Pathways in a Lysosomal Storage Disease T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39722371; 4037070 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Fukuda, T AU - Zaal, K AU - Ralston, E AU - Plotz, P AU - Raben, N Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Lysosomal storage diseases KW - Storage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39722371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Dysfunction+of+Endocytic+and+Autophagic+Pathways+in+a+Lysosomal+Storage+Disease&rft.au=Fukuda%2C+T%3BZaal%2C+K%3BRalston%2C+E%3BPlotz%2C+P%3BRaben%2C+N&rft.aulast=Fukuda&rft.aufirst=T&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Case-Control Statistical Comparison of LD Patterns for Genetic Association Studies T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39721948; 4038536 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Zaykin, D V AU - Meng, Z Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Statistics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39721948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Case-Control+Statistical+Comparison+of+LD+Patterns+for+Genetic+Association+Studies&rft.au=Zaykin%2C+D+V%3BMeng%2C+Z&rft.aulast=Zaykin&rft.aufirst=D&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Myotilin Mutations are Associated with a Significant Number of Myofibrillar Myopathy Cases T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39721936; 4036968 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Shatunov, A AU - Olive, M AU - Hilton-Jones, D AU - Ferrer, I AU - Dalakas, M C AU - Goldfarb, L G Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Mutation KW - Myopathy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39721936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Myotilin+Mutations+are+Associated+with+a+Significant+Number+of+Myofibrillar+Myopathy+Cases&rft.au=Shatunov%2C+A%3BOlive%2C+M%3BHilton-Jones%2C+D%3BFerrer%2C+I%3BDalakas%2C+M+C%3BGoldfarb%2C+L+G&rft.aulast=Shatunov&rft.aufirst=A&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Linkage Scans for HDL-C, Triglycerides and Apolipoprotein AI in Three Populations and Comparison with the NHLBI Genelink Meta-Analyses T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39720190; 4037966 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Klos, K.L.E. AU - Kardia, S.L.R. AU - Turner, S T AU - Hanis, C AU - Cupples, L A AU - Hunt, S C AU - Mahaney, M C AU - Pate, S R AU - Province, M A AU - Rice, T AU - Berenson, G S AU - Boerwinkle, E Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Triglycerides KW - Apolipoproteins KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39720190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Linkage+Scans+for+HDL-C%2C+Triglycerides+and+Apolipoprotein+AI+in+Three+Populations+and+Comparison+with+the+NHLBI+Genelink+Meta-Analyses&rft.au=Klos%2C+K.L.E.%3BKardia%2C+S.L.R.%3BTurner%2C+S+T%3BHanis%2C+C%3BCupples%2C+L+A%3BHunt%2C+S+C%3BMahaney%2C+M+C%3BPate%2C+S+R%3BProvince%2C+M+A%3BRice%2C+T%3BBerenson%2C+G+S%3BBoerwinkle%2C+E&rft.aulast=Klos&rft.aufirst=K.L.E.&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - How to Use the Online NCI/NCBI Entrez Cancer Chromosomes Search Database T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39719879; 4036346 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Knutsen, T AU - Gobu, V AU - Ried, T AU - Sirotkin, K Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Chromosomes KW - Databases KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39719879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=How+to+Use+the+Online+NCI%2FNCBI+Entrez+Cancer+Chromosomes+Search+Database&rft.au=Knutsen%2C+T%3BGobu%2C+V%3BRied%2C+T%3BSirotkin%2C+K&rft.aulast=Knutsen&rft.aufirst=T&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Factors Associated with an Increased Frequency of CDKN2A Mutations in Melanoma-Prone Families T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39719705; 4036507 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Goldstein, A M Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Mutation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39719705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Factors+Associated+with+an+Increased+Frequency+of+CDKN2A+Mutations+in+Melanoma-Prone+Families&rft.au=Goldstein%2C+A+M&rft.aulast=Goldstein&rft.aufirst=A&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of IL-4, MxA, and IRF-1 Genes in Filipino Patients with Subacute Sclerosing Panencephalitis T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39717876; 4038621 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Silao, C.L.T. AU - Pipo-Deveza, J R AU - Kusuhara, K AU - Salonga, A M AU - Lukban, M B AU - Sanchez, B C AU - Kira, R AU - Torisu, H AU - Hara, T Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Interferon regulatory factor 1 KW - Interleukin 4 KW - Subacute sclerosing panencephalitis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39717876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Analysis+of+IL-4%2C+MxA%2C+and+IRF-1+Genes+in+Filipino+Patients+with+Subacute+Sclerosing+Panencephalitis&rft.au=Silao%2C+C.L.T.%3BPipo-Deveza%2C+J+R%3BKusuhara%2C+K%3BSalonga%2C+A+M%3BLukban%2C+M+B%3BSanchez%2C+B+C%3BKira%2C+R%3BTorisu%2C+H%3BHara%2C+T&rft.aulast=Silao&rft.aufirst=C.L.T.&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Profiling of Murine Spermatogenesis Leads to the Identification of mArd2, a Novel Mouse Ard1 Homolog that is Preferentially Expressed Starting from Meiosis. T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39716077; 4037110 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Pang, A.L.Y. AU - Johnson, W AU - Bear, D H AU - Rennert, O M AU - Chan, W Y Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Profiling KW - Spermatogenesis KW - Gene expression KW - Meiosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39716077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Gene+Expression+Profiling+of+Murine+Spermatogenesis+Leads+to+the+Identification+of+mArd2%2C+a+Novel+Mouse+Ard1+Homolog+that+is+Preferentially+Expressed+Starting+from+Meiosis.&rft.au=Pang%2C+A.L.Y.%3BJohnson%2C+W%3BBear%2C+D+H%3BRennert%2C+O+M%3BChan%2C+W+Y&rft.aulast=Pang&rft.aufirst=A.L.Y.&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Discoveries with Computational Analysis of SAGE Data of Mouse Germ-Cell Transcriptome at different Stages of Spermatogenesis T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39713486; 4037482 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Lee, T L AU - Alba, D AU - Baxendale, V AU - Rennert, O M AU - Chan, W Y Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Spermatogenesis KW - Computer applications KW - Data processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39713486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Discoveries+with+Computational+Analysis+of+SAGE+Data+of+Mouse+Germ-Cell+Transcriptome+at+different+Stages+of+Spermatogenesis&rft.au=Lee%2C+T+L%3BAlba%2C+D%3BBaxendale%2C+V%3BRennert%2C+O+M%3BChan%2C+W+Y&rft.aulast=Lee&rft.aufirst=T&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High Density Mapping Studies On Chromosomal Regions 1, 3, 6, 12, 13 and 17 in 28 Families with Chronic Lymphocytic Leukemia. T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39712911; 4037732 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Ng, D. AU - Marti, G E AU - Fontaine, L AU - Toro, J R AU - Caporaso, N AU - Goldin, L R Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Chromosomes KW - Chronic lymphatic leukemia KW - Gene mapping KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39712911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=High+Density+Mapping+Studies+On+Chromosomal+Regions+1%2C+3%2C+6%2C+12%2C+13+and+17+in+28+Families+with+Chronic+Lymphocytic+Leukemia.&rft.au=Ng%2C+D.%3BMarti%2C+G+E%3BFontaine%2C+L%3BToro%2C+J+R%3BCaporaso%2C+N%3BGoldin%2C+L+R&rft.aulast=Ng&rft.aufirst=D.&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Genetic Variant in the Neuropeptide Y Gene (NPY) is Associated with Energy Balance and Obesity in Pima Indians T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39712414; 4038113 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Muller, Y L AU - Bogardus, C AU - Baier, L Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Energy balance KW - Obesity KW - Neuropeptide Y KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39712414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=A+Genetic+Variant+in+the+Neuropeptide+Y+Gene+%28NPY%29+is+Associated+with+Energy+Balance+and+Obesity+in+Pima+Indians&rft.au=Muller%2C+Y+L%3BBogardus%2C+C%3BBaier%2C+L&rft.aulast=Muller&rft.aufirst=Y&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association of Variants in the CD244 Gene with Type 2 Diabetes in Pima Indians T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39711061; 4036927 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Guo, Y AU - Ossowski, V AU - Wolford, J AU - Hanson, R L AU - Kobes, S AU - Bogardus, C AU - Prochazka, M Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Diabetes mellitus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39711061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Association+of+Variants+in+the+CD244+Gene+with+Type+2+Diabetes+in+Pima+Indians&rft.au=Guo%2C+Y%3BOssowski%2C+V%3BWolford%2C+J%3BHanson%2C+R+L%3BKobes%2C+S%3BBogardus%2C+C%3BProchazka%2C+M&rft.aulast=Guo&rft.aufirst=Y&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cognitive and Language Deficits Among Children with Chronic Neuronopathic Gaucher Disease T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39710543; 4036797 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Schiffmann, R AU - Goker-Alpan, O AU - Wiggs, E AU - Eblan, M AU - Sidransky, E Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Children KW - Language KW - Cognitive ability KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39710543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Cognitive+and+Language+Deficits+Among+Children+with+Chronic+Neuronopathic+Gaucher+Disease&rft.au=Schiffmann%2C+R%3BGoker-Alpan%2C+O%3BWiggs%2C+E%3BEblan%2C+M%3BSidransky%2C+E&rft.aulast=Schiffmann&rft.aufirst=R&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Occipital Horn Syndrome in Brothers with a Missense Mutation in the ATP-binding domain of ATP7A T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39708414; 4036454 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Tang, J AU - Robertson, S AU - Kaler, S G Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Symptoms KW - Horns KW - Missense mutation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39708414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Occipital+Horn+Syndrome+in+Brothers+with+a+Missense+Mutation+in+the+ATP-binding+domain+of+ATP7A&rft.au=Tang%2C+J%3BRobertson%2C+S%3BKaler%2C+S+G&rft.aulast=Tang&rft.aufirst=J&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Perfect Sensitivity and Specificity of Plasma Catechol Measurements for Neonatal Diagnosis of Menkes Disease T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39708182; 4038363 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Holmes, C S AU - Kaler, S G Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Specificity KW - Menkes disease KW - Neonates KW - Catechol KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39708182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Perfect+Sensitivity+and+Specificity+of+Plasma+Catechol+Measurements+for+Neonatal+Diagnosis+of+Menkes+Disease&rft.au=Holmes%2C+C+S%3BKaler%2C+S+G&rft.aulast=Holmes&rft.aufirst=C&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evidence for Multiple Distinct Obesity/Type 2 Diabetes Mellitus Loci Under A Single Peak of Linkage On Chromosome 11Q23: Replication in Ethnically Diverse Populations. T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39706177; 4037774 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Baier, L AU - Muller, Y AU - Ma, L. AU - Traurig, M AU - Kovacs, P AU - Bottner, A AU - Stone, S AU - Timms, K AU - Groves, C J AU - McCarthy, M AU - Erdos, M AU - Conneely, K AU - Boehnke, M AU - Miyake, K AU - Atwood, L AU - Johansson, L AU - Ridderstale, M AU - Knowler, W AU - Hanson, R AU - Bogardus, C Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Obesity KW - Chromosomes KW - Chromosome 11 KW - Replication KW - Population genetics KW - Diabetes mellitus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39706177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Evidence+for+Multiple+Distinct+Obesity%2FType+2+Diabetes+Mellitus+Loci+Under+A+Single+Peak+of+Linkage+On+Chromosome+11Q23%3A+Replication+in+Ethnically+Diverse+Populations.&rft.au=Baier%2C+L%3BMuller%2C+Y%3BMa%2C+L.%3BTraurig%2C+M%3BKovacs%2C+P%3BBottner%2C+A%3BStone%2C+S%3BTimms%2C+K%3BGroves%2C+C+J%3BMcCarthy%2C+M%3BErdos%2C+M%3BConneely%2C+K%3BBoehnke%2C+M%3BMiyake%2C+K%3BAtwood%2C+L%3BJohansson%2C+L%3BRidderstale%2C+M%3BKnowler%2C+W%3BHanson%2C+R%3BBogardus%2C+C&rft.aulast=Baier&rft.aufirst=L&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New dbSNP Resources to Support Genotype and Haplotype Submissions T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39704253; 4037586 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Sherry, S T Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Haplotypes KW - Genotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39704253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=New+dbSNP+Resources+to+Support+Genotype+and+Haplotype+Submissions&rft.au=Sherry%2C+S+T&rft.aulast=Sherry&rft.aufirst=S&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cost-Benefit Analysis of the Newborn Screening Program of the Philippines T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39701247; 4037546 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Padilla, C D AU - Dans, L F AU - Estrada, S C AU - Tamondong, M R AU - Bernal, R.M.S. Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Philippines KW - Neonates KW - Screening KW - Cost-benefit analysis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39701247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Cost-Benefit+Analysis+of+the+Newborn+Screening+Program+of+the+Philippines&rft.au=Padilla%2C+C+D%3BDans%2C+L+F%3BEstrada%2C+S+C%3BTamondong%2C+M+R%3BBernal%2C+R.M.S.&rft.aulast=Padilla&rft.aufirst=C&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Methods for Stratified Analysis of Association Studies in Fine-Mapping Type 2 Diabetes in Multiple Populations for Chromosome 1q T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39699908; 4038422 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Hanson, R AU - Zeggini, E AU - Rayner, W AU - Mitchell, B AU - O'Connell, J AU - Shuldiner, A AU - Elbein, S AU - Ng, M.C.Y. AU - Xiang, K AU - Froguel, P AU - Deloukas, P AU - McCarthy, M AU - Knowler, W Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Chromosome 1 KW - Chromosomes KW - Diabetes mellitus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39699908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Comparison+of+Methods+for+Stratified+Analysis+of+Association+Studies+in+Fine-Mapping+Type+2+Diabetes+in+Multiple+Populations+for+Chromosome+1q&rft.au=Hanson%2C+R%3BZeggini%2C+E%3BRayner%2C+W%3BMitchell%2C+B%3BO%27Connell%2C+J%3BShuldiner%2C+A%3BElbein%2C+S%3BNg%2C+M.C.Y.%3BXiang%2C+K%3BFroguel%2C+P%3BDeloukas%2C+P%3BMcCarthy%2C+M%3BKnowler%2C+W&rft.aulast=Hanson&rft.aufirst=R&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Chaperones in Gaucher Disease T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39692944; 4038744 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Urban, D AU - Goker-Alpan, O AU - Stubblefield, B K AU - Sidransky, E Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Chaperones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39692944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Molecular+Chaperones+in+Gaucher+Disease&rft.au=Urban%2C+D%3BGoker-Alpan%2C+O%3BStubblefield%2C+B+K%3BSidransky%2C+E&rft.aulast=Urban&rft.aufirst=D&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Conserved Regulatory Elements in the Glucocerebrosidase Gene Locus. T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39686808; 4037130 DE: JF - 55th Annual Meeting of the American Society of Human Genetics AU - Hruska, K S AU - LaMarca, M E AU - Ziegler, S G AU - Portnoy, M E AU - Green, E D AU - Sidransky, E Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39686808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Analysis+of+Conserved+Regulatory+Elements+in+the+Glucocerebrosidase+Gene+Locus.&rft.au=Hruska%2C+K+S%3BLaMarca%2C+M+E%3BZiegler%2C+S+G%3BPortnoy%2C+M+E%3BGreen%2C+E+D%3BSidransky%2C+E&rft.aulast=Hruska&rft.aufirst=K&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Auditory and Vision Phenotype of Waltzer Cdh23v-6J and Ames Waltzer Pcdh15av-Jfb Double Mutant Mice: No Evidence of Retinitis Pigmentosa or Digenic Inheritance of Progressive Hearing Loss. T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39686634; 4037083 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Ahmed, Z AU - Haywood-Watson II, R.J.L. AU - Riazuddin, S AU - Kjellstrom, S AU - Bush, R A AU - Hampton, L L AU - Battey, J F AU - Sieving, P A AU - Frolenkov, G AU - Friedman, T B Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Vision KW - Phenotypes KW - Mutants KW - Mice KW - Retinitis pigmentosa KW - Heredity KW - Hearing loss KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39686634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Auditory+and+Vision+Phenotype+of+Waltzer+Cdh23v-6J+and+Ames+Waltzer+Pcdh15av-Jfb+Double+Mutant+Mice%3A+No+Evidence+of+Retinitis+Pigmentosa+or+Digenic+Inheritance+of+Progressive+Hearing+Loss.&rft.au=Ahmed%2C+Z%3BHaywood-Watson+II%2C+R.J.L.%3BRiazuddin%2C+S%3BKjellstrom%2C+S%3BBush%2C+R+A%3BHampton%2C+L+L%3BBattey%2C+J+F%3BSieving%2C+P+A%3BFrolenkov%2C+G%3BFriedman%2C+T+B&rft.aulast=Ahmed&rft.aufirst=Z&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Mouse Model Employing the tet-off System in an Antisense Construct to Prkar1A Confirms tTA-Independent Expression of the Transgene and Develops Tumors Consistent with Carney Complex (MIM160980) T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39684284; 4036398 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Griffin, K J AU - Weinberg, F AU - Stergiopoulos, S AU - Matyakhina, L AU - Kirschner, L AU - Stratakis, C Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Animal models KW - Carney complex KW - Antisense KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39684284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=A+Mouse+Model+Employing+the+tet-off+System+in+an+Antisense+Construct+to+Prkar1A+Confirms+tTA-Independent+Expression+of+the+Transgene+and+Develops+Tumors+Consistent+with+Carney+Complex+%28MIM160980%29&rft.au=Griffin%2C+K+J%3BWeinberg%2C+F%3BStergiopoulos%2C+S%3BMatyakhina%2C+L%3BKirschner%2C+L%3BStratakis%2C+C&rft.aulast=Griffin&rft.aufirst=K&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association of Common Variation in AGTR1 with Left Ventricular Mass in the Framingham Heart Study T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39678882; 4036420 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Hirschhorn, J N Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Heart KW - Circulatory system KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39678882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Association+of+Common+Variation+in+AGTR1+with+Left+Ventricular+Mass+in+the+Framingham+Heart+Study&rft.au=Hirschhorn%2C+J+N&rft.aulast=Hirschhorn&rft.aufirst=J&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Investigation of Cholesterol Biosynthesis by Cortisol-Producing, Benign Tumors of the Adrenal Gland T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39675482; 4036492 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Wassif, C AU - Horvath, A AU - Sterner, A AU - Porter, F AU - Stratakis, C Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Cholesterol KW - Adrenal glands KW - Benign KW - Biosynthesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39675482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=An+Investigation+of+Cholesterol+Biosynthesis+by+Cortisol-Producing%2C+Benign+Tumors+of+the+Adrenal+Gland&rft.au=Wassif%2C+C%3BHorvath%2C+A%3BSterner%2C+A%3BPorter%2C+F%3BStratakis%2C+C&rft.aulast=Wassif&rft.aufirst=C&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Variations of Non-Synonymous Mutations in MBL2 in different Human Populations Provide Evidence for Recent Natural Selection T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39647818; 4037615 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Bernig, T AU - Tarazona-Santos, E AU - Modi, W S AU - Yeager, M AU - Welch, R A AU - Chanock, S Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Natural selection KW - Mutation KW - Population genetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39647818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=Genetic+Variations+of+Non-Synonymous+Mutations+in+MBL2+in+different+Human+Populations+Provide+Evidence+for+Recent+Natural+Selection&rft.au=Bernig%2C+T%3BTarazona-Santos%2C+E%3BModi%2C+W+S%3BYeager%2C+M%3BWelch%2C+R+A%3BChanock%2C+S&rft.aulast=Bernig&rft.aufirst=T&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MtDNA Sequence Heterogeneity in Single Cells from Leukemia Patients T2 - 55th Annual Meeting of the American Society of Human Genetics AN - 39631614; 4036615 JF - 55th Annual Meeting of the American Society of Human Genetics AU - Yao, Y G AU - Ogasawara, Y AU - Kajigaya, S AU - Molldrem, J J AU - Falcao, R P AU - Pintao, M C AU - McCoy, J P AU - Keyvanafar, K AU - Rizzatti, E G AU - Young, N S Y1 - 2005/10/25/ PY - 2005 DA - 2005 Oct 25 KW - Leukemia KW - Mitochondrial DNA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39631614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.atitle=MtDNA+Sequence+Heterogeneity+in+Single+Cells+from+Leukemia+Patients&rft.au=Yao%2C+Y+G%3BOgasawara%2C+Y%3BKajigaya%2C+S%3BMolldrem%2C+J+J%3BFalcao%2C+R+P%3BPintao%2C+M+C%3BMcCoy%2C+J+P%3BKeyvanafar%2C+K%3BRizzatti%2C+E+G%3BYoung%2C+N+S&rft.aulast=Yao&rft.aufirst=Y&rft.date=2005-10-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Human+Genetics&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/menu-annmeet.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association of the CYP1B1*3 Allele with Survival in Patients with Prostate Cancer Receiving Docetaxel T2 - 2005 Annual Meeting of the American College of Clinical Pharmacy AN - 39796172; 4039538 JF - 2005 Annual Meeting of the American College of Clinical Pharmacy AU - Sissung, Tristan M AU - Danesi, Romano AU - Price, Douglas K AU - Steinberg, Seth M AU - Wit, Ronald De AU - Cox, Michael C AU - Dahut, William AU - Figg, William Sr AU - Sparreboom, Alex Y1 - 2005/10/23/ PY - 2005 DA - 2005 Oct 23 KW - Survival KW - Allelles KW - Prostate cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39796172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Meeting+of+the+American+College+of+Clinical+Pharmacy&rft.atitle=Association+of+the+CYP1B1*3+Allele+with+Survival+in+Patients+with+Prostate+Cancer+Receiving+Docetaxel&rft.au=Sissung%2C+Tristan+M%3BDanesi%2C+Romano%3BPrice%2C+Douglas+K%3BSteinberg%2C+Seth+M%3BWit%2C+Ronald+De%3BCox%2C+Michael+C%3BDahut%2C+William%3BFigg%2C+William+Sr%3BSparreboom%2C+Alex&rft.aulast=Sissung&rft.aufirst=Tristan&rft.date=2005-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Meeting+of+the+American+College+of+Clinical+Pharmacy&rft.issn=&rft_id=info:doi/ L2 - http://www.accp.com/am05_abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polymorphism in the Hypoxia-Inducible Factor 1A Gene May Confer Susceptibility to Androgen-Independent Prostate Cancer T2 - 2005 Annual Meeting of the American College of Clinical Pharmacy AN - 39728226; 4039495 JF - 2005 Annual Meeting of the American College of Clinical Pharmacy AU - Chau, Cindy H AU - Permenter, Matthew G AU - Steinberg, Seth M AU - Retter, Avi S AU - Dahut, William L AU - Price, Douglas K AU - Figg, William D Y1 - 2005/10/23/ PY - 2005 DA - 2005 Oct 23 KW - Prostate cancer KW - Gene polymorphism KW - Hypoxia-inducible factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39728226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Meeting+of+the+American+College+of+Clinical+Pharmacy&rft.atitle=Polymorphism+in+the+Hypoxia-Inducible+Factor+1A+Gene+May+Confer+Susceptibility+to+Androgen-Independent+Prostate+Cancer&rft.au=Chau%2C+Cindy+H%3BPermenter%2C+Matthew+G%3BSteinberg%2C+Seth+M%3BRetter%2C+Avi+S%3BDahut%2C+William+L%3BPrice%2C+Douglas+K%3BFigg%2C+William+D&rft.aulast=Chau&rft.aufirst=Cindy&rft.date=2005-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Meeting+of+the+American+College+of+Clinical+Pharmacy&rft.issn=&rft_id=info:doi/ L2 - http://www.accp.com/am05_abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Pharmacokinetic (PK) Study of Oral CC-5013, a Novel Thalidomide Analogue, in Patients with Refractory Metastatic Cancer. T2 - 2005 Annual Meeting of the American College of Clinical Pharmacy AN - 39727996; 4039421 JF - 2005 Annual Meeting of the American College of Clinical Pharmacy AU - Tohnya, Tanyifor AU - Sparreboom, Alex AU - Venitz, Jurgen AU - Parker, Catherine AU - Dahut, William L AU - Figg, William D Y1 - 2005/10/23/ PY - 2005 DA - 2005 Oct 23 KW - Pharmacokinetics KW - Metastases KW - Cancer KW - Thalidomide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39727996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Meeting+of+the+American+College+of+Clinical+Pharmacy&rft.atitle=A+Pharmacokinetic+%28PK%29+Study+of+Oral+CC-5013%2C+a+Novel+Thalidomide+Analogue%2C+in+Patients+with+Refractory+Metastatic+Cancer.&rft.au=Tohnya%2C+Tanyifor%3BSparreboom%2C+Alex%3BVenitz%2C+Jurgen%3BParker%2C+Catherine%3BDahut%2C+William+L%3BFigg%2C+William+D&rft.aulast=Tohnya&rft.aufirst=Tanyifor&rft.date=2005-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Meeting+of+the+American+College+of+Clinical+Pharmacy&rft.issn=&rft_id=info:doi/ L2 - http://www.accp.com/am05_abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association of Genetic Variants in ABCB1 and CYP3A4/5 with the Pharmacokinetics of Erlotinib T2 - 2005 Annual Meeting of the American College of Clinical Pharmacy AN - 39709693; 4039542 JF - 2005 Annual Meeting of the American College of Clinical Pharmacy AU - Scripture, Charity D AU - Sissung, Tristan M AU - Permenter, Matthew G AU - Price, Douglas K AU - Swain, Sandra M AU - Sparreboom, Alex AU - Figg, William D Y1 - 2005/10/23/ PY - 2005 DA - 2005 Oct 23 KW - Pharmacokinetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39709693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Meeting+of+the+American+College+of+Clinical+Pharmacy&rft.atitle=Association+of+Genetic+Variants+in+ABCB1+and+CYP3A4%2F5+with+the+Pharmacokinetics+of+Erlotinib&rft.au=Scripture%2C+Charity+D%3BSissung%2C+Tristan+M%3BPermenter%2C+Matthew+G%3BPrice%2C+Douglas+K%3BSwain%2C+Sandra+M%3BSparreboom%2C+Alex%3BFigg%2C+William+D&rft.aulast=Scripture&rft.aufirst=Charity&rft.date=2005-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Meeting+of+the+American+College+of+Clinical+Pharmacy&rft.issn=&rft_id=info:doi/ L2 - http://www.accp.com/am05_abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Human mitochondrial ClpP is a stable heptamer that assembles into a tetradecamer in the presence of ClpX. AN - 68693876; 16115876 AB - The functional form of ClpP, the proteolytic component of ATP-dependent Clp proteases, is a hollow-cored particle composed of two heptameric rings joined face-to-face forming an aqueous chamber containing the proteolytic active sites. We have found that isolated human mitochondrial ClpP (hClpP) is stable as a heptamer and remains a monodisperse species (s(20,w) 7.0 S; M(app) 169, 200) at concentrations > or = 3 mg/ml. Heptameric hClpP has no proteolytic activity and very low peptidase activity. In the presence of ATP, hClpX interacts with hClpP forming a complex, which by equilibrium sedimentation measurements has a M(app) of 1 x 10(6). Electron microscopy confirmed that the complex consisted of a double ring of hClpP with an hClpX ring axially aligned on each end. The hClpXP complex has protease activity and greatly increased peptidase activity, indicating that interaction with hClpX affects the conformation of the hClpP catalytic active site. A mutant of hClpP, in which a cysteine residue was introduced into the handle region at the interface between the two rings formed stable tetradecamers under oxidizing conditions but spontaneously dissociated into two heptamers upon reduction. Thus, hClpP rings interact transiently but very weakly in solution, and hClpX must exert an allosteric effect on hClpP to promote a conformation that stabilizes the tetradecamer. These data suggest that hClpX can regulate the appearance of hClpP peptidase activity in mitochondria and might affect the nature of the degradation products released during ATP-dependent proteolytic cycles. JF - The Journal of biological chemistry AU - Kang, Sung Gyun AU - Dimitrova, Mariana N AU - Ortega, Joaquin AU - Ginsburg, Ann AU - Maurizi, Michael R AD - Laboratory of Cell Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2005/10/21/ PY - 2005 DA - 2005 Oct 21 SP - 35424 EP - 35432 VL - 280 IS - 42 SN - 0021-9258, 0021-9258 KW - Cross-Linking Reagents KW - 0 KW - Disulfides KW - Recombinant Proteins KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Histidine KW - 4QD397987E KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Peptide Hydrolases KW - EC 3.4.- KW - Trypsin KW - EC 3.4.21.4 KW - Endopeptidase Clp KW - EC 3.4.21.92 KW - Cysteine KW - K848JZ4886 KW - Glutaral KW - T3C89M417N KW - Index Medicus KW - Animals KW - Humans KW - Hydrogen-Ion Concentration KW - Liver -- metabolism KW - Mutagenesis KW - Rats KW - Cysteine -- chemistry KW - Chromatography, Gel KW - Chromatin Immunoprecipitation KW - Microscopy, Electron KW - Recombinant Proteins -- chemistry KW - Time Factors KW - Protein Conformation KW - Peptide Hydrolases -- chemistry KW - Green Fluorescent Proteins -- chemistry KW - Glutaral -- pharmacology KW - Dimerization KW - Cross-Linking Reagents -- pharmacology KW - Ultracentrifugation KW - Hydrolysis KW - Protein Binding KW - Binding Sites KW - Adenosine Triphosphate -- chemistry KW - Histidine -- chemistry KW - Disulfides -- chemistry KW - Allosteric Site KW - Protein Structure, Tertiary KW - Trypsin -- pharmacology KW - Mutation KW - Mitochondria -- enzymology KW - Mitochondria -- metabolism KW - Endopeptidase Clp -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68693876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Human+mitochondrial+ClpP+is+a+stable+heptamer+that+assembles+into+a+tetradecamer+in+the+presence+of+ClpX.&rft.au=Kang%2C+Sung+Gyun%3BDimitrova%2C+Mariana+N%3BOrtega%2C+Joaquin%3BGinsburg%2C+Ann%3BMaurizi%2C+Michael+R&rft.aulast=Kang&rft.aufirst=Sung&rft.date=2005-10-21&rft.volume=280&rft.issue=42&rft.spage=35424&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-13 N1 - Date created - 2005-10-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mutational analysis of the catalytic domain of O-linked N-acetylglucosaminyl transferase. AN - 68692561; 16105839 AB - O-Linked N-acetylglucosaminyltransferase (OGT) catalyzes the transfer of O-linked GlcNAc to serine/threonine residues of a variety of target proteins, many of which have been implicated in such diseases as diabetes and neurodegeneration. The addition of O-GlcNAc to proteins occurs in response to fluctuations in cellular concentrations of UDP-GlcNAc, which result from nutrients entering the hexosamine biosynthetic pathway. However, the molecular mechanisms involved in sugar nucleotide recognition and transfer to protein are poorly understood. We employed site-directed mutagenesis to target potentially important amino acid residues within the two conserved catalytic domains of OGT (CD I and CD II), followed by an in vitro glycosylation assay to evaluate N-acetylglucosaminyltransferase activity after bacterial expression. Although many of the amino acid substitutions caused inactivation of the enzyme, we identified three amino acid residues (two in CD I and one in CD II) that produced viable enzymes when mutated. Structure-based homology modeling revealed that these permissive mutants may be either in or near the sugar nucleotide-binding site. Our findings suggest a model in which the two conserved regions of the catalytic domain, CD I and CD II, contribute to the formation of a UDP-GlcNAc-binding pocket that catalyzes the transfer of O-GlcNAc to substrate proteins. Identification of viable OGT mutants may facilitate examination of its role in nutrient sensing and signal transduction cascades. JF - The Journal of biological chemistry AU - Lazarus, Brooke D AU - Roos, Mark D AU - Hanover, John A AD - Laboratory of Cell Biology and Biochemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2005/10/21/ PY - 2005 DA - 2005 Oct 21 SP - 35537 EP - 35544 VL - 280 IS - 42 SN - 0021-9258, 0021-9258 KW - Hexosamines KW - 0 KW - Nucleotides KW - N-Acetylglucosaminyltransferases KW - EC 2.4.1.- KW - O-GlcNAc transferase KW - Index Medicus KW - Hexosamines -- chemistry KW - Electrophoresis, Polyacrylamide Gel KW - Models, Molecular KW - Humans KW - Nuclear Pore -- chemistry KW - Catalytic Domain KW - Nucleotides -- chemistry KW - Amino Acid Sequence KW - Glycosylation KW - Protein Binding KW - Binding Sites KW - Mutagenesis, Site-Directed KW - Genetic Vectors KW - Kinetics KW - Point Mutation KW - Molecular Sequence Data KW - Insulin Resistance KW - Sequence Homology, Amino Acid KW - Protein Structure, Tertiary KW - Mutation KW - Signal Transduction KW - Protein Conformation KW - N-Acetylglucosaminyltransferases -- metabolism KW - DNA Mutational Analysis KW - N-Acetylglucosaminyltransferases -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68692561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Mutational+analysis+of+the+catalytic+domain+of+O-linked+N-acetylglucosaminyl+transferase.&rft.au=Lazarus%2C+Brooke+D%3BRoos%2C+Mark+D%3BHanover%2C+John+A&rft.aulast=Lazarus&rft.aufirst=Brooke&rft.date=2005-10-21&rft.volume=280&rft.issue=42&rft.spage=35537&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-13 N1 - Date created - 2005-10-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Changing Sequence Specificity of Human Pumilio-Homology Domain T2 - VI Symposium on RNA Biology AN - 39758428; 4032357 JF - VI Symposium on RNA Biology AU - Cheong, Cheom-gil AU - Hall, Traci M. Tanaka Y1 - 2005/10/21/ PY - 2005 DA - 2005 Oct 21 KW - Specificity KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39758428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=VI+Symposium+on+RNA+Biology&rft.atitle=Changing+Sequence+Specificity+of+Human+Pumilio-Homology+Domain&rft.au=Cheong%2C+Cheom-gil%3BHall%2C+Traci+M.+Tanaka&rft.aulast=Cheong&rft.aufirst=Cheom-gil&rft.date=2005-10-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=VI+Symposium+on+RNA+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.med.unc.edu/pmbb/Schedule_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Small RNAs as Part of the Cellular Stress Response T2 - VI Symposium on RNA Biology AN - 39758275; 4032335 JF - VI Symposium on RNA Biology AU - Gottesman, Susan AU - Guillier, Maude AU - Vanderpool, Carin AU - Thompson, Karl AU - Majdalani, Nadim Y1 - 2005/10/21/ PY - 2005 DA - 2005 Oct 21 KW - Stress KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39758275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=VI+Symposium+on+RNA+Biology&rft.atitle=Small+RNAs+as+Part+of+the+Cellular+Stress+Response&rft.au=Gottesman%2C+Susan%3BGuillier%2C+Maude%3BVanderpool%2C+Carin%3BThompson%2C+Karl%3BMajdalani%2C+Nadim&rft.aulast=Gottesman&rft.aufirst=Susan&rft.date=2005-10-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=VI+Symposium+on+RNA+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.med.unc.edu/pmbb/Schedule_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exon Definition Regulates Alternative RNA Splicing in DNA Tumor Virus Gene Expression T2 - VI Symposium on RNA Biology AN - 39754833; 4032402 JF - VI Symposium on RNA Biology AU - Zheng, Zhi-Ming Y1 - 2005/10/21/ PY - 2005 DA - 2005 Oct 21 KW - Nucleic acids KW - Alternative splicing KW - Exons KW - Gene expression KW - RNA KW - DNA tumor viruses KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39754833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=VI+Symposium+on+RNA+Biology&rft.atitle=Exon+Definition+Regulates+Alternative+RNA+Splicing+in+DNA+Tumor+Virus+Gene+Expression&rft.au=Zheng%2C+Zhi-Ming&rft.aulast=Zheng&rft.aufirst=Zhi-Ming&rft.date=2005-10-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=VI+Symposium+on+RNA+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.med.unc.edu/pmbb/Schedule_Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Phase I study of O6-benzylguanine and temozolomide administered daily for 5 days to pediatric patients with solid tumors. AN - 68700934; 16234526 AB - This pediatric phase I trial of O6-benzylguanine (O6BG) and temozolomide (TMZ) on a daily schedule for 5 days, every 28 days was performed to determine the maximum-tolerated dose of TMZ when given with a biologically active dose of O6BG and to define the toxicity profile of the combination in children with solid tumors. Patients < or = 21 years old with refractory solid tumors were eligible. O6BG was administered intravenously over 60 minutes daily for 5 days. TMZ was administered orally 30 minutes after completion of each O6BG infusion. Starting doses of O6BG and TMZ were 60 mg/m2/d and 28 mg/m2/d, respectively. O6BG was escalated to 90 and 120 mg/m2/d; TMZ was subsequently escalated to 40, 55, 75, and 100 mg/m2/d. Cycles were repeated every 28 days. Forty-one patients were enrolled; 32 patients were assessable for toxicity. The combination of O6BG and TMZ was tolerable at TMZ doses less than half of the conventional dose of 200 mg/m2/d. Myelosuppression occurred sporadically at all dose levels and was the dose-limiting toxicity (DLT) at 100 mg/m2/d of TMZ combined with 120 mg/m2/d O6BG. Nonhematologic toxicities were generally mild. Evidence of antitumor activity was observed at 120 mg/m2/d O6BG combined with TMZ doses of 55 mg/m2/d and above. The recommended doses of O6BG administered with TMZ on a 5-day schedule in children are 120 mg/m2/d of O6BG and 75 mg/m2/d of TMZ. Evidence of activity was observed at these doses. Myelosuppression was the DLT. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Warren, Katherine E AU - Aikin, Alberta A AU - Libucha, Madeleine AU - Widemann, Brigitte C AU - Fox, Elizabeth AU - Packer, Roger J AU - Balis, Frank M AD - National Cancer Institute Neuro-Oncology Branch, Building 82, Room 219, 9030 Old Georgetown Rd, Bethesda, MD 20892-8200, USA. warrenk@mail.nih.gov Y1 - 2005/10/20/ PY - 2005 DA - 2005 Oct 20 SP - 7646 EP - 7653 VL - 23 IS - 30 SN - 0732-183X, 0732-183X KW - O(6)-benzylguanine KW - 01KC87F8FE KW - Guanine KW - 5Z93L87A1R KW - Dacarbazine KW - 7GR28W0FJI KW - temozolomide KW - YF1K15M17Y KW - Index Medicus KW - Drug Administration Schedule KW - Injections, Intravenous KW - Dose-Response Relationship, Drug KW - Humans KW - Prognosis KW - Child KW - Guanine -- administration & dosage KW - Child, Preschool KW - Dacarbazine -- analogs & derivatives KW - Adult KW - Dacarbazine -- administration & dosage KW - Guanine -- analogs & derivatives KW - Maximum Tolerated Dose KW - Adolescent KW - Male KW - Female KW - Neoplasms -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68700934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Phase+I+study+of+O6-benzylguanine+and+temozolomide+administered+daily+for+5+days+to+pediatric+patients+with+solid+tumors.&rft.au=Warren%2C+Katherine+E%3BAikin%2C+Alberta+A%3BLibucha%2C+Madeleine%3BWidemann%2C+Brigitte+C%3BFox%2C+Elizabeth%3BPacker%2C+Roger+J%3BBalis%2C+Frank+M&rft.aulast=Warren&rft.aufirst=Katherine&rft.date=2005-10-20&rft.volume=23&rft.issue=30&rft.spage=7646&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-21 N1 - Date created - 2005-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pegylated arginine deiminase treatment of patients with metastatic melanoma: results from phase I and II studies. AN - 68699758; 16234528 AB - Individuals with metastatic melanoma have a poor prognosis. Many human melanomas are auxotrophic for arginine, and arginine is not an essential amino acid in humans. We hypothesized that this auxotrophy may be therapeutically exploited. A novel amino acid-degrading enzyme (arginine deiminase) conjugated to polyethylene glycol (ADI-SS PEG 20,000 mw) was used to lower plasma arginine in individuals with metastatic melanoma. Two cohort dose-escalation studies were performed. A phase I study in the United States enrolled 15 patients, and a phase I to II study in Italy enrolled 24 patients. The Italian patients also received two subsequent cycles of treatment, each consisting of four once-weekly injections of 160 U/m2. The goals of these studies were to determine pharmacokinetics (PK), pharmacodynamics (PD), safety, and the antitumor activity of ADI-SS PEG 20,000 mw. PK and PD studies indicated that a dose of 160 U/m2 lowered plasma arginine from a resting level of approximately 130 micromol/L to less than 2 micromol/L for at least 7 days; nitric oxide levels also were lowered. There were no grade 3 or 4 toxicities directly attributable to the drug. Six of 24 phase I to II patients responded to treatment (five partial responses and one complete response; 25% response rate) and also had prolonged survival. CONCLUSION Elimination of all detectable plasma arginine in patients with metastatic melanoma was well tolerated and may be effective in the treatment of this cancer. Further testing of ADI-SS PEG 20,000 mw in a larger population of individuals with metastatic melanoma is warranted. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Ascierto, Paolo A AU - Scala, Stefania AU - Castello, Giuseppe AU - Daponte, Antonio AU - Simeone, Ester AU - Ottaiano, Alessandro AU - Beneduce, Gerardo AU - De Rosa, Vincenzo AU - Izzo, Francesco AU - Melucci, Maria Teresa AU - Ensor, C Mark AU - Prestayko, Archie W AU - Holtsberg, Frederick W AU - Bomalaski, John S AU - Clark, Mike A AU - Savaraj, Niramol AU - Feun, Lynn G AU - Logan, Theodore F AD - Pascale National Cancer Institute, Naples, Italy. Y1 - 2005/10/20/ PY - 2005 DA - 2005 Oct 20 SP - 7660 EP - 7668 VL - 23 IS - 30 SN - 0732-183X, 0732-183X KW - Polyethylene Glycols KW - 30IQX730WE KW - Nitric Oxide KW - 31C4KY9ESH KW - Arginine KW - 94ZLA3W45F KW - Hydrolases KW - EC 3.- KW - arginine deiminase KW - EC 3.5.3.6 KW - Index Medicus KW - United States KW - Survival Rate KW - Aged, 80 and over KW - Humans KW - Adult KW - Treatment Outcome KW - Nitric Oxide -- metabolism KW - Aged KW - Middle Aged KW - Arginine -- blood KW - Maximum Tolerated Dose KW - Male KW - Italy KW - Female KW - Skin Neoplasms -- drug therapy KW - Skin Neoplasms -- enzymology KW - Hydrolases -- pharmacology KW - Melanoma -- genetics KW - Melanoma -- enzymology KW - Polyethylene Glycols -- pharmacokinetics KW - Melanoma -- drug therapy KW - Hydrolases -- pharmacokinetics KW - Hydrolases -- administration & dosage KW - Polyethylene Glycols -- pharmacology KW - Polyethylene Glycols -- administration & dosage KW - Skin Neoplasms -- secondary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68699758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Pegylated+arginine+deiminase+treatment+of+patients+with+metastatic+melanoma%3A+results+from+phase+I+and+II+studies.&rft.au=Ascierto%2C+Paolo+A%3BScala%2C+Stefania%3BCastello%2C+Giuseppe%3BDaponte%2C+Antonio%3BSimeone%2C+Ester%3BOttaiano%2C+Alessandro%3BBeneduce%2C+Gerardo%3BDe+Rosa%2C+Vincenzo%3BIzzo%2C+Francesco%3BMelucci%2C+Maria+Teresa%3BEnsor%2C+C+Mark%3BPrestayko%2C+Archie+W%3BHoltsberg%2C+Frederick+W%3BBomalaski%2C+John+S%3BClark%2C+Mike+A%3BSavaraj%2C+Niramol%3BFeun%2C+Lynn+G%3BLogan%2C+Theodore+F&rft.aulast=Ascierto&rft.aufirst=Paolo&rft.date=2005-10-20&rft.volume=23&rft.issue=30&rft.spage=7660&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-21 N1 - Date created - 2005-10-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J Clin Oncol. 2006 Aug 20;24(24):4047 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Interferon Regulation of IL-15 and IL-15 Receptor Alpha Expression: Implications for Immunotherapy T2 - 2005 Annual Meeting of the International Society for Interferon and Cytokine Research AN - 39905190; 4076223 JF - 2005 Annual Meeting of the International Society for Interferon and Cytokine Research AU - Waldmann, Thomas A Y1 - 2005/10/20/ PY - 2005 DA - 2005 Oct 20 KW - Immunotherapy KW - Interleukin 15 receptors KW - Interferon KW - Interleukin 15 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39905190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.atitle=Interferon+Regulation+of+IL-15+and+IL-15+Receptor+Alpha+Expression%3A+Implications+for+Immunotherapy&rft.au=Waldmann%2C+Thomas+A&rft.aulast=Waldmann&rft.aufirst=Thomas&rft.date=2005-10-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.sibcb.ac.cn/Final%20Announcement.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - GATA3 and the Induction and Maintenance of Th2 Function T2 - 2005 Annual Meeting of the International Society for Interferon and Cytokine Research AN - 39905076; 4076197 JF - 2005 Annual Meeting of the International Society for Interferon and Cytokine Research AU - Paul, William E Y1 - 2005/10/20/ PY - 2005 DA - 2005 Oct 20 KW - Lymphocytes T KW - GATA-3 protein KW - Helper cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39905076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.atitle=GATA3+and+the+Induction+and+Maintenance+of+Th2+Function&rft.au=Paul%2C+William+E&rft.aulast=Paul&rft.aufirst=William&rft.date=2005-10-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.sibcb.ac.cn/Final%20Announcement.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Glucocorticoid Receptor: One Gene, Many Proteins, Extensive Post Translational Modifications: Mechanisms Tissue Specific Anti-Inflammatory Actions T2 - 2005 Annual Meeting of the International Society for Interferon and Cytokine Research AN - 39830828; 4076208 JF - 2005 Annual Meeting of the International Society for Interferon and Cytokine Research AU - Cidlowski, John A Y1 - 2005/10/20/ PY - 2005 DA - 2005 Oct 20 KW - Translation KW - Glucocorticoid receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39830828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.atitle=The+Glucocorticoid+Receptor%3A+One+Gene%2C+Many+Proteins%2C+Extensive+Post+Translational+Modifications%3A+Mechanisms+Tissue+Specific+Anti-Inflammatory+Actions&rft.au=Cidlowski%2C+John+A&rft.aulast=Cidlowski&rft.aufirst=John&rft.date=2005-10-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.sibcb.ac.cn/Final%20Announcement.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytokines as Critical Co-Stimulatory Molecules in Modulating the Immune Response of Natural Killer Cells T2 - 2005 Annual Meeting of the International Society for Interferon and Cytokine Research AN - 39813826; 4076198 JF - 2005 Annual Meeting of the International Society for Interferon and Cytokine Research AU - Young, Howard A Y1 - 2005/10/20/ PY - 2005 DA - 2005 Oct 20 KW - Immune response KW - Cytokines KW - Natural killer cells KW - Immunity KW - Defense mechanisms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39813826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.atitle=Cytokines+as+Critical+Co-Stimulatory+Molecules+in+Modulating+the+Immune+Response+of+Natural+Killer+Cells&rft.au=Young%2C+Howard+A&rft.aulast=Young&rft.aufirst=Howard&rft.date=2005-10-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.sibcb.ac.cn/Final%20Announcement.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Interferon alphas: Structure and Function T2 - 2005 Annual Meeting of the International Society for Interferon and Cytokine Research AN - 39805881; 4076213 JF - 2005 Annual Meeting of the International Society for Interferon and Cytokine Research AU - Zoon, Kathryn C Y1 - 2005/10/20/ PY - 2005 DA - 2005 Oct 20 KW - Interferon KW - Structure-function relationships KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39805881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.atitle=Human+Interferon+alphas%3A+Structure+and+Function&rft.au=Zoon%2C+Kathryn+C&rft.aulast=Zoon&rft.aufirst=Kathryn&rft.date=2005-10-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.sibcb.ac.cn/Final%20Announcement.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Decreased Expression of Interferon-g in CD4@@u+@T Cells Due to Hypermethylation of Following HAART Treatment in Normal and HIV Infected Donors T2 - 2005 Annual Meeting of the International Society for Interferon and Cytokine Research AN - 39799584; 4076244 JF - 2005 Annual Meeting of the International Society for Interferon and Cytokine Research AU - Ruscetti, Frank Y1 - 2005/10/20/ PY - 2005 DA - 2005 Oct 20 KW - ^g-Interferon KW - Highly active antiretroviral therapy KW - Disease control KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39799584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.atitle=Decreased+Expression+of+Interferon-g+in+CD4%40%40u%2B%40T+Cells+Due+to+Hypermethylation+of+Following+HAART+Treatment+in+Normal+and+HIV+Infected+Donors&rft.au=Ruscetti%2C+Frank&rft.aulast=Ruscetti&rft.aufirst=Frank&rft.date=2005-10-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.sibcb.ac.cn/Final%20Announcement.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dendritic Cells and Type I Interferon: Virus Infection and More T2 - 2005 Annual Meeting of the International Society for Interferon and Cytokine Research AN - 39785931; 4076199 JF - 2005 Annual Meeting of the International Society for Interferon and Cytokine Research AU - Trinchieri, Giorgio Y1 - 2005/10/20/ PY - 2005 DA - 2005 Oct 20 KW - Infection KW - Interferon KW - Dendritic cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39785931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.atitle=Dendritic+Cells+and+Type+I+Interferon%3A+Virus+Infection+and+More&rft.au=Trinchieri%2C+Giorgio&rft.aulast=Trinchieri&rft.aufirst=Giorgio&rft.date=2005-10-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.sibcb.ac.cn/Final%20Announcement.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of IRF-8 in the Development of Dendritic Cell Subtypes and Type I IFN Transcription T2 - 2005 Annual Meeting of the International Society for Interferon and Cytokine Research AN - 39777390; 4076188 JF - 2005 Annual Meeting of the International Society for Interferon and Cytokine Research AU - Ozato, Keiko Y1 - 2005/10/20/ PY - 2005 DA - 2005 Oct 20 KW - Transcription KW - Dendritic cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39777390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.atitle=The+Role+of+IRF-8+in+the+Development+of+Dendritic+Cell+Subtypes+and+Type+I+IFN+Transcription&rft.au=Ozato%2C+Keiko&rft.aulast=Ozato&rft.aufirst=Keiko&rft.date=2005-10-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.sibcb.ac.cn/Final%20Announcement.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Alternative p38 Activation Pathway in T Cells: Regulation by the Autoimmune Suppressor Gadd45 a T2 - 2005 Annual Meeting of the International Society for Interferon and Cytokine Research AN - 39758720; 4076201 JF - 2005 Annual Meeting of the International Society for Interferon and Cytokine Research AU - Ashwell, Jonathan D Y1 - 2005/10/20/ PY - 2005 DA - 2005 Oct 20 KW - GADD45 protein KW - Lymphocytes T KW - Cell activation KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39758720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Annual+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.atitle=Alternative+p38+Activation+Pathway+in+T+Cells%3A+Regulation+by+the+Autoimmune+Suppressor+Gadd45+a&rft.au=Ashwell%2C+Jonathan+D&rft.aulast=Ashwell&rft.aufirst=Jonathan&rft.date=2005-10-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Annual+Meeting+of+the+International+Society+for+Interferon+and+Cytokine+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.sibcb.ac.cn/Final%20Announcement.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - The eIF1A C-terminal domain promotes initiation complex assembly, scanning and AUG selection in vivo. AN - 68704218; 16193068 AB - Translation initiation factor 1A stimulates 40S-binding of the eukaryotic initiation factor 2 (eIF2)/GTP/Met-tRNA(iMet) ternary complex (TC) and promotes scanning in vitro. eIF1A contains an OB-fold present in bacterial IF1 plus N- and C-terminal extensions. Truncating the C-terminus (deltaC) or mutating OB-fold residues (66-70) of eIF1A reduced general translation in vivo but increased GCN4 translation (Gcd- phenotype) in a manner suppressed by overexpressing TC. Consistent with this, both mutations diminished 40S-bound TC, eIF5 and eIF3 in vivo, and deltaC impaired TC recruitment in vitro. The assembly defects of the OB-fold mutation can be attributed to reduced 40S-binding of eIF1A, whereas deltaC impairs eIF1A function on the ribosome. A substitution in the C-terminal helix (98-101) also reduced 43S assembly in vivo. Rather than producing a Gcd- phenotype, however, 98-101 impairs GCN4 derepression in a manner consistent with defective scanning by reinitiating ribosomes. Indeed, 98-101 allows formation of aberrant 48S complexes in vitro and increases utilization of non-AUG codons in vivo. Thus, the OB-fold is crucial for ribosome-binding and the C-terminal domain of eIF1A has eukaryotic-specific functions in TC recruitment and scanning. JF - The EMBO journal AU - Fekete, Christie A AU - Applefield, Drew J AU - Blakely, Stephen A AU - Shirokikh, Nikolay AU - Pestova, Tatyana AU - Lorsch, Jon R AU - Hinnebusch, Alan G AD - Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA. Y1 - 2005/10/19/ PY - 2005 DA - 2005 Oct 19 SP - 3588 EP - 3601 VL - 24 IS - 20 SN - 0261-4189, 0261-4189 KW - Codon, Initiator KW - 0 KW - Eukaryotic Initiation Factor-1 KW - Saccharomyces cerevisiae Proteins KW - eukaryotic peptide initiation factor-1A KW - Index Medicus KW - Protein Structure, Tertiary -- genetics KW - Mutation KW - Sequence Deletion KW - Mutagenesis KW - Codon, Initiator -- metabolism KW - Saccharomyces cerevisiae Proteins -- metabolism KW - Saccharomyces cerevisiae Proteins -- genetics KW - Peptide Chain Initiation, Translational KW - Eukaryotic Initiation Factor-1 -- metabolism KW - Eukaryotic Initiation Factor-1 -- chemistry KW - Saccharomyces cerevisiae Proteins -- chemistry KW - Eukaryotic Initiation Factor-1 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68704218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+EMBO+journal&rft.atitle=The+eIF1A+C-terminal+domain+promotes+initiation+complex+assembly%2C+scanning+and+AUG+selection+in+vivo.&rft.au=Fekete%2C+Christie+A%3BApplefield%2C+Drew+J%3BBlakely%2C+Stephen+A%3BShirokikh%2C+Nikolay%3BPestova%2C+Tatyana%3BLorsch%2C+Jon+R%3BHinnebusch%2C+Alan+G&rft.aulast=Fekete&rft.aufirst=Christie&rft.date=2005-10-19&rft.volume=24&rft.issue=20&rft.spage=3588&rft.isbn=&rft.btitle=&rft.title=The+EMBO+journal&rft.issn=02614189&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-20 N1 - Date created - 2005-10-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Mol Biol. 1995 Apr 28;248(2):207-10 [7739034] Mol Cell Biol. 1991 May;11(5):2723-35 [2017175] EMBO J. 1997 Mar 17;16(6):1436-43 [9135158] Yeast. 1997 Jun 15;13(7):647-53 [9200814] Genes Dev. 1997 Sep 15;11(18):2396-413 [9308967] Electrophoresis. 1997 Dec;18(15):2714-23 [9504803] Mol Cell Biol. 1998 Aug;18(8):4935-46 [9671501] Nature. 1998 Aug 27;394(6696):854-9 [9732867] EMBO J. 1999 Mar 15;18(6):1673-88 [10075937] J Biol Chem. 2004 Nov 26;279(48):49644-55 [15377664] Mol Cell. 2005 Jan 21;17(2):265-75 [15664195] RNA. 2005 Apr;11(4):470-86 [15703437] Mol Cell Biol. 2005 Jul;25(13):5480-91 [15964804] Mol Cell. 2000 Jan;5(1):109-19 [10678173] Mol Cell Biol. 2000 Oct;20(19):7183-91 [10982835] Genes Dev. 2000 Oct 1;14(19):2534-46 [11018020] Cell. 1992 Feb 7;68(3):585-96 [1739968] Mol Cell Biol. 1994 Apr;14(4):2616-28 [8139562] Nucleic Acids Res. 1994 Nov 11;22(22):4673-80 [7984417] Science. 2001 Jan 19;291(5503):498-501 [11228145] EMBO J. 2001 May 1;20(9):2326-37 [11331597] RNA. 2002 Mar;8(3):382-97 [12008673] EMBO J. 2002 Nov 1;21(21):5886-98 [12411506] Genes Dev. 2002 Nov 15;16(22):2906-22 [12435632] EMBO J. 2003 Jan 15;22(2):193-204 [12514125] J Biol Chem. 2003 Feb 21;278(8):6580-7 [12493757] Genes Dev. 2003 Mar 15;17(6):786-99 [12651896] J Mol Biol. 2003 Jul 25;330(5):917-24 [12860115] Mol Cell Biol. 2003 Aug;23(15):5431-45 [12861028] EMBO J. 2004 Mar 10;23(5):1166-77 [14976554] Mol Cell Biol. 2004 Nov;24(21):9437-55 [15485912] Mol Cell Biol. 1985 Sep;5(9):2349-60 [3915540] Mol Cell Biol. 1988 Jul;8(7):2955-63 [3043200] Yeast. 1985 Dec;1(2):83-138 [3916863] Gene. 1988 Dec 30;74(2):527-34 [3073106] Proc Natl Acad Sci U S A. 1990 Nov;87(21):8301-5 [2236042] Mol Cell Biol. 1991 Jan;11(1):486-96 [1986242] Mol Cell Biol. 1995 Nov;15(11):6351-63 [7565788] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Diazeniumdiolate ions as leaving groups in anomeric displacement reactions: a protection-deprotection strategy for ionic diazeniumdiolates. AN - 68684924; 16218605 AB - Diazeniumdiolate ions [R2N-N(O)=N-O-] are of growing interest pharmacologically for their ability to generate up to two molar equivalents of bioactive nitric oxide (NO) spontaneously on protonating the amino nitrogen. Accordingly, their stability increases as the pH is raised. Here we show that the corresponding beta-glucosides [R2N-N(O)=N-O-Glc] decreased in stability with pH; when R2N was diethylamino, the rate equation was kobs = ko + kOH- [OH-], where ko = 7.8 x 10-7 s-1 and kOH- = 5.3 x 10-3 M-1 s-1. The primary products were 1,6-anhydroglucose and the regenerated R2N-N(O)=N-O- ion. The results were qualitatively similar to those of beta-glucosyl fluoride and p-nitrophenoxide, whose hydrolyses have been rationalized as proceeding via a glycal oxide intermediate. This chemistry offers a convenient strategy for protecting heat- and acid-sensitive diazeniumdiolate ions during manipulations that would otherwise destroy them. As an example, a poly(urethane) film that generated NO in physiological buffer at a surface flux comparable to that of the mammalian vascular endothelium was prepared by glucosylating the ionic diazeniumdiolate group attached to the diol monomer before reacting it with the bis-isocyanate, then removing the saccharide with base when the protecting group was no longer needed. JF - Journal of the American Chemical Society AU - Showalter, Brett M AU - Reynolds, Melissa M AU - Valdez, Carlos A AU - Saavedra, Joseph E AU - Davies, Keith M AU - Klose, John R AU - Chmurny, Gwendolyn N AU - Citro, Michael L AU - Barchi, Joseph J AU - Merz, Scott I AU - Meyerhoff, Mark E AU - Keefer, Larry K AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA. Y1 - 2005/10/19/ PY - 2005 DA - 2005 Oct 19 SP - 14188 EP - 14189 VL - 127 IS - 41 SN - 0002-7863, 0002-7863 KW - Azo Compounds KW - 0 KW - diazeniumdiolate KW - Index Medicus KW - Molecular Structure KW - Hydrogen-Ion Concentration KW - Time Factors KW - Hydrolysis KW - Azo Compounds -- chemical synthesis KW - Azo Compounds -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68684924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Chemical+Society&rft.atitle=Diazeniumdiolate+ions+as+leaving+groups+in+anomeric+displacement+reactions%3A+a+protection-deprotection+strategy+for+ionic+diazeniumdiolates.&rft.au=Showalter%2C+Brett+M%3BReynolds%2C+Melissa+M%3BValdez%2C+Carlos+A%3BSaavedra%2C+Joseph+E%3BDavies%2C+Keith+M%3BKlose%2C+John+R%3BChmurny%2C+Gwendolyn+N%3BCitro%2C+Michael+L%3BBarchi%2C+Joseph+J%3BMerz%2C+Scott+I%3BMeyerhoff%2C+Mark+E%3BKeefer%2C+Larry+K&rft.aulast=Showalter&rft.aufirst=Brett&rft.date=2005-10-19&rft.volume=127&rft.issue=41&rft.spage=14188&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Chemical+Society&rft.issn=00027863&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-24 N1 - Date created - 2005-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Introduction to Nci'S Integrative Cancer Biology Program T2 - Sixth International Conference on Systems Biology (ICSB 2005) AN - 40053581; 4017306 JF - Sixth International Conference on Systems Biology (ICSB 2005) AU - Gallahan, Dan Y1 - 2005/10/19/ PY - 2005 DA - 2005 Oct 19 KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40053581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+International+Conference+on+Systems+Biology+%28ICSB+2005%29&rft.atitle=Introduction+to+Nci%27S+Integrative+Cancer+Biology+Program&rft.au=Gallahan%2C+Dan&rft.aulast=Gallahan&rft.aufirst=Dan&rft.date=2005-10-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+International+Conference+on+Systems+Biology+%28ICSB+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://csbi.mit.edu/icsb-2005/program/program.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Assessing the Health Effects of Dietary Supplements and Food Ingredients T2 - 6th International Conference and Exhibition on Nutraceuticals and Functional Foods (WORLDNUTRA 2005) AN - 40105917; 4001175 JF - 6th International Conference and Exhibition on Nutraceuticals and Functional Foods (WORLDNUTRA 2005) AU - Coates, Paul M Y1 - 2005/10/16/ PY - 2005 DA - 2005 Oct 16 KW - Food KW - Dietary supplements KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40105917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+International+Conference+and+Exhibition+on+Nutraceuticals+and+Functional+Foods+%28WORLDNUTRA+2005%29&rft.atitle=Assessing+the+Health+Effects+of+Dietary+Supplements+and+Food+Ingredients&rft.au=Coates%2C+Paul+M&rft.aulast=Coates&rft.aufirst=Paul&rft.date=2005-10-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+International+Conference+and+Exhibition+on+Nutraceuticals+and+Functional+Foods+%28WORLDNUTRA+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.worldnutra.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Challenges in Identyfying and Characterizing Bioactive Components in Foods and Supplements T2 - 6th International Conference and Exhibition on Nutraceuticals and Functional Foods (WORLDNUTRA 2005) AN - 40056709; 4001231 JF - 6th International Conference and Exhibition on Nutraceuticals and Functional Foods (WORLDNUTRA 2005) AU - Betz, Joseph M Y1 - 2005/10/16/ PY - 2005 DA - 2005 Oct 16 KW - Food KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40056709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+International+Conference+and+Exhibition+on+Nutraceuticals+and+Functional+Foods+%28WORLDNUTRA+2005%29&rft.atitle=Challenges+in+Identyfying+and+Characterizing+Bioactive+Components+in+Foods+and+Supplements&rft.au=Betz%2C+Joseph+M&rft.aulast=Betz&rft.aufirst=Joseph&rft.date=2005-10-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+International+Conference+and+Exhibition+on+Nutraceuticals+and+Functional+Foods+%28WORLDNUTRA+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.worldnutra.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Latest on Dietary Supplement Research and Development T2 - 6th International Conference and Exhibition on Nutraceuticals and Functional Foods (WORLDNUTRA 2005) AN - 40002627; 4001146 JF - 6th International Conference and Exhibition on Nutraceuticals and Functional Foods (WORLDNUTRA 2005) AU - Coates, Paul M Y1 - 2005/10/16/ PY - 2005 DA - 2005 Oct 16 KW - Research KW - Dietary supplements KW - Development KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40002627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+International+Conference+and+Exhibition+on+Nutraceuticals+and+Functional+Foods+%28WORLDNUTRA+2005%29&rft.atitle=The+Latest+on+Dietary+Supplement+Research+and+Development&rft.au=Coates%2C+Paul+M&rft.aulast=Coates&rft.aufirst=Paul&rft.date=2005-10-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+International+Conference+and+Exhibition+on+Nutraceuticals+and+Functional+Foods+%28WORLDNUTRA+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.worldnutra.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Kinetics of tempol for prevention of xerostomia following head and neck irradiation in a mouse model. AN - 68709412; 16243832 AB - Radiotherapy is commonly used to treat the majority of patients with head and neck cancers. Salivary glands in the radiation field are dramatically affected by this procedure. The purpose of this study was to examine pharmacokinetic characteristics of the stable nitroxide 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (tempol) with respect to radioprotection of the salivary glands. To evaluate the effect of different doses and times of administration, the heads of C3H mice were exposed to a single irradiation dose of 15 Gy, with i.p. tempol injection. To analyze other routes of administration, we injected 275 mg/kg tempol by an i.m., i.v., or s.c. route, 10 minutes before irradiation. We also tested whether oral administration of tempol in a topical form (either in a mouthwash or gel) provided any salivary gland protection. Tempol treatment (137.5 or 275 mg/kg, i.p., 10 minutes before irradiation) significantly reduced irradiation-induced salivary hypofunction (approximately 50-60%). I.v. or s.c. administration of tempol also showed significant radioprotection, whereas i.m. administration proved to be ineffective. Topical use of tempol, either as a mouthwash or gel, also was radioprotective. Our results strongly suggest that tempol is a promising candidate for clinical application to protect salivary glands in patients undergoing radiotherapy for head and neck cancers. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Cotrim, Ana P AU - Sowers, Anastasia L AU - Lodde, Beatrijs M AU - Vitolo, Joseph M AU - Kingman, Albert AU - Russo, Angelo AU - Mitchell, James B AU - Baum, Bruce J AD - Gene Therapy and Therapeutics Branch and Biostatistics Core, Division of Clinical Research and Health Promotion, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland 20892, USA. acotrim@nidcr.nih.gov Y1 - 2005/10/15/ PY - 2005 DA - 2005 Oct 15 SP - 7564 EP - 7568 VL - 11 IS - 20 SN - 1078-0432, 1078-0432 KW - Cyclic N-Oxides KW - 0 KW - Radiation-Protective Agents KW - Spin Labels KW - tempol KW - U78ZX2F65X KW - Index Medicus KW - Models, Animal KW - Injections, Intraperitoneal KW - Salivary Glands -- radiation effects KW - Animals KW - Salivary Glands -- drug effects KW - Salivation -- radiation effects KW - Salivation -- drug effects KW - Salivary Glands -- pathology KW - Mice, Inbred C3H KW - Injections, Subcutaneous KW - Mice KW - Female KW - Drug Administration Routes KW - Xerostomia -- etiology KW - Xerostomia -- prevention & control KW - Radiation-Protective Agents -- administration & dosage KW - Radiation-Protective Agents -- pharmacokinetics KW - Cranial Irradiation -- adverse effects KW - Cyclic N-Oxides -- administration & dosage KW - Xerostomia -- metabolism KW - Cyclic N-Oxides -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68709412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Kinetics+of+tempol+for+prevention+of+xerostomia+following+head+and+neck+irradiation+in+a+mouse+model.&rft.au=Cotrim%2C+Ana+P%3BSowers%2C+Anastasia+L%3BLodde%2C+Beatrijs+M%3BVitolo%2C+Joseph+M%3BKingman%2C+Albert%3BRusso%2C+Angelo%3BMitchell%2C+James+B%3BBaum%2C+Bruce+J&rft.aulast=Cotrim&rft.aufirst=Ana&rft.date=2005-10-15&rft.volume=11&rft.issue=20&rft.spage=7564&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-13 N1 - Date created - 2005-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Polymorphisms in cytokine and cellular adhesion molecule genes and susceptibility to hematotoxicity among workers exposed to benzene. AN - 68699300; 16230423 AB - Benzene is a recognized hematotoxin and leukemogen but its mechanism of action and the role of genetic susceptibility are still unclear. Cytokines, chemokines, and cellular adhesion molecules are soluble proteins that play an important regulatory role in hematopoiesis. We therefore hypothesized that variation in these genes could influence benzene-induced hematotoxicity. We analyzed common, well-studied single-nucleotide polymorphisms (SNPs) in 20 candidate genes drawn from these pathways in a study of 250 workers exposed to benzene and 140 unexposed controls in China. After accounting for multiple comparisons, SNPs in five genes were associated with a statistically significant decrease in total WBC counts among exposed workers [IL-1A (-889C>T), IL-4 (-1098T>G), IL-10 (-819T>C), IL-12A (8685G>A), and VCAM1 (-1591T>C)], and one SNP [CSF3 (Ex4-165C>T)] was associated with an increase in WBC counts. The adhesion molecule VCAM1 variant was particularly noteworthy as it was associated with a decrease in B cells, natural killer cells, CD4+ T cells, and monocytes. Further, VCAM1 (-1591T>C) and CSF3 (Ex4-165C>T) were associated, respectively, with decreased (P = 0.041) and increased (P = 0.076) CFU-GEMM progenitor cell colony formation in 29 benzene-exposed workers. This is the first report to provide evidence that SNPs in genes that regulate hematopoiesis influence benzene-induced hematotoxicity. JF - Cancer research AU - Lan, Qing AU - Zhang, Luoping AU - Shen, Min AU - Smith, Martyn T AU - Li, Guilan AU - Vermeulen, Roel AU - Rappaport, Stephen M AU - Forrest, Matthew S AU - Hayes, Richard B AU - Linet, Martha AU - Dosemeci, Mustafa AU - Alter, Blanche P AU - Weinberg, Rona S AU - Yin, Songnian AU - Yeager, Meredith AU - Welch, Robert AU - Waidyanatha, Suramya AU - Kim, Sungkyoon AU - Chanock, Stephen AU - Rothman, Nathaniel AD - Division of Cancer Epidemiology, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD 20892-7240, USA. qingl@mail.nih.gov Y1 - 2005/10/15/ PY - 2005 DA - 2005 Oct 15 SP - 9574 EP - 9581 VL - 65 IS - 20 SN - 0008-5472, 0008-5472 KW - Cell Adhesion Molecules KW - 0 KW - Cytokines KW - Benzene KW - J64922108F KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Hematopoiesis -- drug effects KW - Humans KW - Adult KW - Male KW - Hematopoiesis -- genetics KW - Female KW - Occupational Exposure KW - Hematologic Diseases -- genetics KW - Hematologic Diseases -- chemically induced KW - Occupational Diseases -- genetics KW - Cytokines -- genetics KW - Cell Adhesion Molecules -- genetics KW - Occupational Diseases -- chemically induced KW - Benzene -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68699300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Polymorphisms+in+cytokine+and+cellular+adhesion+molecule+genes+and+susceptibility+to+hematotoxicity+among+workers+exposed+to+benzene.&rft.au=Lan%2C+Qing%3BZhang%2C+Luoping%3BShen%2C+Min%3BSmith%2C+Martyn+T%3BLi%2C+Guilan%3BVermeulen%2C+Roel%3BRappaport%2C+Stephen+M%3BForrest%2C+Matthew+S%3BHayes%2C+Richard+B%3BLinet%2C+Martha%3BDosemeci%2C+Mustafa%3BAlter%2C+Blanche+P%3BWeinberg%2C+Rona+S%3BYin%2C+Songnian%3BYeager%2C+Meredith%3BWelch%2C+Robert%3BWaidyanatha%2C+Suramya%3BKim%2C+Sungkyoon%3BChanock%2C+Stephen%3BRothman%2C+Nathaniel&rft.aulast=Lan&rft.aufirst=Qing&rft.date=2005-10-15&rft.volume=65&rft.issue=20&rft.spage=9574&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-19 N1 - Date created - 2005-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Less efficient g2-m checkpoint is associated with an increased risk of lung cancer in African Americans. AN - 68699250; 16230422 AB - Cell cycle checkpoints play critical roles in the maintenance of genomic integrity. The inactivation of checkpoint genes by genetic and epigenetic mechanisms is frequent in all cancer types, as a less-efficient cell cycle control can lead to genetic instability and tumorigenesis. In an on-going case-control study consisting of 216 patients with non-small cell lung cancer, 226 population-based controls, and 114 hospital-based controls, we investigated the relationship of gamma-radiation-induced G2-M arrest and lung cancer risk. Peripheral blood lymphocytes were cultured for 90 hours, exposed to 1.0 Gy gamma-radiation, and harvested at 3 hours after gamma-radiation treatment. gamma-Radiation-induced G2-M arrest was measured as the percentage of mitotic cells in untreated cultures minus the percentage of mitotic cells in gamma-radiation-treated cultures from the same subject. The mean percentage of gamma-radiation-induced G2-M arrest was significantly lower in cases than in population controls (1.18 versus 1.44, P < 0.01) and hospital controls (1.18 versus 1.40, P = 0.01). When dichotomized at the 50th percentile value in combined controls (population and hospital controls), a lower level of gamma-radiation-induced G2-M arrest was associated with an increased risk of lung cancer among African Americans after adjusting for baseline mitotic index, age, gender, and pack-years of smoking [adjusted odd ratio (OR), 2.25; 95% confidence interval (95% CI), 0.97-5.20]. A significant trend of an increased risk of lung cancer with a decreased level of G2-M arrest was observed (P(trend) = 0.02) among African Americans, with a lowest-versus-highest quartile adjusted OR of 3.74 (95% CI, 0.98-14.3). This trend was most apparent among African American females (P(trend) < 0.01), with a lowest-versus-highest quartile adjusted OR of 11.75 (95% CI, 1.47-94.04). The results suggest that a less-efficient DNA damage-induced G2-M checkpoint is associated with an increased risk of lung cancer among African Americans. Interestingly, we observed a stronger association of DNA damage-induced G2-M arrest and lung cancer among African Americans when compared with Caucasians. If replicated, these results may provide clues to the exceedingly high lung cancer incidence experienced by African Americans. JF - Cancer research AU - Zheng, Yun-Ling AU - Loffredo, Christopher A AU - Alberg, Anthony J AU - Yu, Zhipeng AU - Jones, Raymond T AU - Perlmutter, Donna AU - Enewold, Lindsey AU - Krasna, Mark J AU - Yung, Rex AU - Shields, Peter G AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, MD 20892-4255, USA. Y1 - 2005/10/15/ PY - 2005 DA - 2005 Oct 15 SP - 9566 EP - 9573 VL - 65 IS - 20 SN - 0008-5472, 0008-5472 KW - Index Medicus KW - Gamma Rays KW - Risk Factors KW - Humans KW - Lymphocytes -- radiation effects KW - Case-Control Studies KW - Aged KW - African Americans KW - Middle Aged KW - Lymphocytes -- cytology KW - Dose-Response Relationship, Radiation KW - Male KW - Female KW - G2 Phase -- radiation effects KW - Carcinoma, Non-Small-Cell Lung -- blood KW - G2 Phase -- genetics KW - Lung Neoplasms -- blood KW - Carcinoma, Non-Small-Cell Lung -- genetics KW - Lung Neoplasms -- genetics KW - African Continental Ancestry Group KW - Cell Division -- genetics KW - Lung Neoplasms -- pathology KW - Cell Division -- radiation effects KW - Carcinoma, Non-Small-Cell Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68699250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Less+efficient+g2-m+checkpoint+is+associated+with+an+increased+risk+of+lung+cancer+in+African+Americans.&rft.au=Zheng%2C+Yun-Ling%3BLoffredo%2C+Christopher+A%3BAlberg%2C+Anthony+J%3BYu%2C+Zhipeng%3BJones%2C+Raymond+T%3BPerlmutter%2C+Donna%3BEnewold%2C+Lindsey%3BKrasna%2C+Mark+J%3BYung%2C+Rex%3BShields%2C+Peter+G%3BHarris%2C+Curtis+C&rft.aulast=Zheng&rft.aufirst=Yun-Ling&rft.date=2005-10-15&rft.volume=65&rft.issue=20&rft.spage=9566&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-19 N1 - Date created - 2005-10-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pathol Biol (Paris). 2000 Apr;48(3):174-81 [10858951] Cancer Res. 2005 Jan 1;65(1):349-57 [15665313] Cell Prolif. 2000 Oct;33(5):261-74 [11063129] Pharmacogenetics. 2000 Dec;10(9):761-6 [11221602] Lung Cancer. 2001 Feb-Mar;31(2-3):157-62 [11165394] Nat Genet. 2001 Apr;27(4):383-91 [11279519] Cancer Epidemiol Biomarkers Prev. 2001 Mar;10(3):217-22 [11303590] Science. 1999 Dec 24;286(5449):2528-31 [10617473] Mol Diagn. 1999 Dec;4(4):299-307 [10671640] Nature. 2000 Mar 30;404(6777):510-4 [10761921] J Clin Oncol. 2000 Jun;18(11):2309-15 [10829052] Genes Chromosomes Cancer. 2002 Jan;33(1):17-21 [11746983] Neoplasma. 2001;48(5):407-11 [11845987] J Natl Cancer Inst. 2002 May 1;94(9):681-90 [11983757] Semin Oncol. 2002 Jun;29(3):246-57 [12063677] Oncogene. 2002 Jun 20;21(27):4191-9 [12082606] Cancer Res. 2002 Aug 15;62(16):4588-91 [12183412] Carcinogenesis. 2003 Feb;24(2):269-74 [12584177] Hum Hered. 2003;55(4):171-8 [14566095] Cancer Res. 2004 Jan 15;64(2):500-8 [14744762] Mol Cancer. 2004 May 4;3:14 [15125777] Mutat Res. 1985 Jan-Feb;148(1-2):71-82 [3969079] Proc Natl Acad Sci U S A. 1985 Aug;82(16):5400-3 [3860870] Int J Cancer. 1989 Mar 15;43(3):403-9 [2466800] Science. 1989 Nov 3;246(4930):629-34 [2683079] Int J Radiat Biol. 1989 Nov;56(5):677-84 [2573663] J Natl Cancer Inst. 1990 Jun 20;82(12):1050-4 [2348470] J Natl Cancer Inst. 1990 Nov 21;82(22):1773-5 [1700135] Science. 1991 Jul 5;253(5015):49-53 [1905840] J Natl Cancer Inst. 1991 Aug 21;83(16):1142-8 [1886147] Cancer Res. 1991 Dec 1;51(23 Pt 1):6304-11 [1933891] Lancet. 1992 May 23;339(8804):1268-78 [1349675] Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7491-5 [1323840] Cell. 1992 Sep 18;70(6):923-35 [1356076] Cancer Epidemiol Biomarkers Prev. 1993 Jan-Feb;2(1):53-7 [8093594] Proc Natl Acad Sci U S A. 1993 May 1;90(9):3988-92 [8387205] Int J Cancer. 1993 Jun 19;54(4):589-93 [8514450] Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9026-30 [8415648] Oncogene. 1999 Nov 1;18(45):6135-44 [10557105] Science. 1994 Dec 16;266(5192):1821-8 [7997877] Cancer Epidemiol Biomarkers Prev. 1995 Mar;4(2):99-103 [7537995] Br Med Bull. 1996 Jan;52(1):12-21 [8746293] Cancer Epidemiol Biomarkers Prev. 1996 Jul;5(7):577-8 [8827363] Int J Radiat Biol. 1997 Jan;71(1):41-9 [9020962] Cell. 1997 Feb 7;88(3):315-21 [9039258] Cancer Res. 1998 Jan 1;58(1):65-70 [9426059] Mol Cell. 1997 Dec;1(1):3-11 [9659898] Carcinogenesis. 1998 Aug;19(8):1329-32 [9744524] Oncogene. 1998 Dec 24;17(25):3301-8 [9916992] Biochem Soc Symp. 1999;64:91-104 [10207623] Carcinogenesis. 1999 Aug;20(8):1465-9 [10426793] Anticancer Res. 1999 May-Jun;19(3A):1827-32 [10470122] J Natl Cancer Inst. 2000 Nov 1;92(21):1764-72 [11058619] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of aspartate 298 in mouse 5-HT3A receptor gating and modulation by extracellular Ca2+. AN - 68689155; 16096341 AB - The TM2-TM3 extracellular loop is critical for activation of the Cys-loop family of ligand-gated ion channels. The contribution of aspartate 298 (D298), an amino acid that links the transmembrane domain 2 (TM2) to the TM2-TM3 loop, in mouse 5-hydroxytryptamine(3A) (5-HT(3A)) receptor function was probed with site-directed mutagenesis in the present study. This negatively charged residue was replaced with an alanine to neutralize the charge, with a glutamate to conserve the charge, or with an arginine to reverse the charge. Human embryonic kidney 293 (HEK 293) cells transfected with the wild-type and mutant receptors were studied by combining whole-cell patch-clamp recording with fast agonist application. The D-->A or D-->R mutations resulted in a receptor with reduced 5-HT potency, and accelerated kinetics of desensitization and deactivation. In addition, the efficacy of partial agonists was reduced by the D-->A mutation. The D-->E mutation produced a receptor with properties similar to those of the wild-type receptor. In addition, the potential role of this residue in modulation of the receptor by extracellular calcium ([Ca(2)(+)](o)) was investigated. Increasing [Ca(2)(+)](o) inhibited 5-HT-activated currents and altered receptor kinetics in a similar manner in the wild-type and D298E receptors, and this alteration was eliminated by the D-->A and D-->R mutations. Our data suggest that the charge at D298 participates in transitions between functional states of the 5-HT(3A) receptor, and provide evidence that the charge of the side-chain at residue D298 contributes to channel gating kinetics and is crucial for Ca(2)(+) modulation. JF - The Journal of physiology AU - Hu, Xiang-Qun AU - Lovinger, David M AD - Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20852, USA. Y1 - 2005/10/15/ PY - 2005 DA - 2005 Oct 15 SP - 381 EP - 396 VL - 568 SN - 0022-3751, 0022-3751 KW - Receptors, Serotonin, 5-HT3 KW - 0 KW - Serotonin 5-HT3 Receptor Agonists KW - Serotonin Receptor Agonists KW - Aspartic Acid KW - 30KYC7MIAI KW - Serotonin KW - 333DO1RDJY KW - 2-methyl-5-HT KW - 78263-90-8 KW - Calcium KW - SY7Q814VUP KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Serotonin Receptor Agonists -- pharmacology KW - Serotonin -- pharmacology KW - Animals KW - Dopamine -- pharmacology KW - Dose-Response Relationship, Drug KW - Humans KW - Serotonin -- analogs & derivatives KW - Amino Acid Sequence KW - Mice KW - Transfection KW - Molecular Sequence Data KW - Point Mutation KW - Membrane Potentials -- drug effects KW - Protein Structure, Tertiary KW - Cell Line KW - Aspartic Acid -- metabolism KW - Kidney -- metabolism KW - Receptors, Serotonin, 5-HT3 -- metabolism KW - Kidney -- drug effects KW - Calcium -- pharmacology KW - Receptors, Serotonin, 5-HT3 -- genetics KW - Receptors, Serotonin, 5-HT3 -- chemistry KW - Aspartic Acid -- chemistry KW - Ion Channel Gating -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68689155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+physiology&rft.atitle=Role+of+aspartate+298+in+mouse+5-HT3A+receptor+gating+and+modulation+by+extracellular+Ca2%2B.&rft.au=Hu%2C+Xiang-Qun%3BLovinger%2C+David+M&rft.aulast=Hu&rft.aufirst=Xiang-Qun&rft.date=2005-10-15&rft.volume=568&rft.issue=&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+physiology&rft.issn=00223751&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-27 N1 - Date created - 2005-10-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Physiol. 1998 Jan 1;506 ( Pt 1):53-72 [9481672] Biophys J. 1999 Apr;76(4):1856-67 [10096884] Mol Pharmacol. 1998 Mar;53(3):511-23 [9495819] J Physiol. 1998 Mar 15;507 ( Pt 3):653-65 [9508827] Pflugers Arch. 1999 Dec;439(1-2):86-92 [10651004] J Biol Chem. 2000 Jul 28;275(30):22764-8 [10801806] J Gen Physiol. 2000 Sep;116(3):327-40 [10962011] Mol Pharmacol. 2001 Apr;59(4):844-51 [11259629] J Neurosci. 2001 Apr 15;21(8):2589-99 [11306612] J Neurosci. 2001 Jun 15;21(12):4143-53 [11404399] Eur J Pharmacol. 2001 Oct 5;428(2):153-61 [11675031] J Biol Chem. 2001 Nov 9;276(45):42035-42 [11557761] J Neurosci. 2001 Dec 1;21(23):9083-91 [11717341] Nat Rev Neurosci. 2002 Feb;3(2):102-14 [11836518] Mol Membr Biol. 2002 Jan-Mar;19(1):11-26 [11989819] J Neurosci. 2002 Oct 1;22(19):8411-21 [12351715] J Biol Chem. 2002 Nov 8;277(45):43002-10 [12226083] J Neurosci. 2002 Dec 1;22(23):10209-16 [12451122] J Biol Chem. 2003 Jan 10;278(2):712-7 [12381728] Nature. 2003 Jan 16;421(6920):272-5 [12529644] Neuron. 2003 Jan 23;37(2):287-97 [12546823] J Neurophysiol. 2003 Apr;89(4):1864-9 [12611954] Nature. 2003 Jun 26;423(6943):949-55 [12827192] J Biol Chem. 2003 Nov 21;278(47):46583-9 [12970351] FEBS Lett. 2003 Nov 27;555(1):91-5 [14630325] J Biol Chem. 2003 Dec 12;278(50):50151-7 [14525990] J Biol Chem. 2004 Jun 11;279(24):25598-604 [15066993] Nature. 2004 Aug 19;430(7002):896-900 [15318223] Pflugers Arch. 1981 Aug;391(2):85-100 [6270629] J Neurophysiol. 1985 Jan;53(1):1-16 [2857775] Adv Neurol. 1986;44:619-39 [3518349] Nature. 1988 Oct 13;335(6191):645-8 [2459620] Eur J Pharmacol. 1988 Jul 14;151(3):491-5 [2463926] Science. 1991 Oct 18;254(5030):432-7 [1718042] EMBO J. 1994 Sep 15;13(18):4223-8 [7925268] J Biol Chem. 1994 Nov 25;269(47):29557-64 [7961941] Nature. 1995 Jan 5;373(6509):37-43 [7800037] Neuron. 1995 Jan;14(1):169-75 [7826634] Trends Neurosci. 1995 Mar;18(3):121-7 [7754520] Neuron. 1995 Jul;15(1):181-91 [7542462] Br J Pharmacol. 1995 Mar;114(6):1211-21 [7620711] Proc Natl Acad Sci U S A. 1996 Jun 11;93(12):6118-23 [8650229] Br J Pharmacol. 1996 Mar;117(5):839-46 [8851499] EMBO J. 1997 Jan 2;16(1):110-20 [9009272] Biophys J. 1997 May;72(5):2103-16 [9129812] J Neurophysiol. 1997 Nov;78(5):2493-502 [9356400] J Physiol. 1998 Mar 1;507 ( Pt 2):335-52 [9518697] Neuroreport. 1998 Jun 22;9(9):1997-2000 [9674581] J Gen Physiol. 1998 Aug;112(2):181-97 [9689026] FEBS Lett. 1998 Aug 14;433(1-2):89-92 [9738939] Br J Pharmacol. 1998 Nov;125(5):924-47 [9846630] J Physiol. 1998 Feb 15;507 ( Pt 1):25-40 [9490812] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Selective cellular effects of overexpressed pleckstrin-homology domains that recognize PtdIns(3,4,5)P3 suggest their interaction with protein binding partners. AN - 68679933; 16219693 AB - Several pleckstrin-homology (PH) domains with the ability to bind phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5)P3, PIP3] were expressed as green fluorescent protein (GFP) fusion proteins to determine their effects on various cellular responses known to be activated by PIP3. These proteins comprised the PH domains of Akt, ARNO, Btk or GRP1, and were found to show growth-factor-stimulated and wortmannin-sensitive translocation from the cytosol to the plasma membrane in several cell types, indicating their ability to recognize PIP3. Remarkably, although overexpressed Akt-PH-GFP and Btk-PH-GFP were quite potent in antagonizing the PIP3-mediated activation of the Akt protein kinase, such inhibition was not observed with the other PH domains. By contrast, expression of the PH domains of GRP1 and ARNO, but not of Akt or Btk, inhibited the attachment and spreading of freshly seeded cells to culture dishes. Activation of PLCgamma by epidermal growth factor (EGF) was attenuated by the PH domains of GRP1, ARNO and Akt, but was significantly enhanced by the Btk PH domain. By following the kinetics of expression of the various GFP-fused PH domains for several days, only the PH domain of Akt showed a lipid-binding-dependent self-elimination, consistent with its interference with the anti-apoptotic Akt signaling pathway. Mutations of selective residues that do not directly participate in PIP3 binding in the GRP1-PH and Akt-PH domain were able to reduce the dominant-negative effects of these constructs yet retain their lipid binding. These data suggest that interaction with and sequestration of PIP3 may not be the sole mechanism by which PH domains interfere with cellular responses and that their interaction with other membrane components, most probably with proteins, allows a more specific participation in the regulation of specific signaling pathways. JF - Journal of cell science AU - Várnai, Péter AU - Bondeva, Tzvetanka AU - Tamás, Péter AU - Tóth, Balázs AU - Buday, László AU - Hunyady, László AU - Balla, Tamas AD - Endocrinology and Reproduction Research Branch, National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2005/10/15/ PY - 2005 DA - 2005 Oct 15 SP - 4879 EP - 4888 VL - 118 SN - 0021-9533, 0021-9533 KW - Androstadienes KW - 0 KW - Blood Proteins KW - Phosphatidylinositol Phosphates KW - Phosphoproteins KW - Receptors, Cytoplasmic and Nuclear KW - phosphatidylinositol 3,4,5-triphosphate KW - phosphatidylinositol receptors KW - platelet protein P47 KW - Epidermal Growth Factor KW - 62229-50-9 KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Phospholipase C gamma KW - EC 3.1.4.3 KW - wortmannin KW - XVA4O219QW KW - Index Medicus KW - Cell Movement KW - Animals KW - Fibroblasts -- drug effects KW - COS Cells KW - Humans KW - Androstadienes -- pharmacology KW - Gene Expression KW - Fibroblasts -- cytology KW - Mice KW - Proto-Oncogene Proteins c-akt -- chemistry KW - Protein Binding KW - NIH 3T3 Cells KW - Mutagenesis KW - Phospholipase C gamma -- metabolism KW - Transfection KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Cercopithecus aethiops KW - Protein Structure, Tertiary KW - Proto-Oncogene Proteins c-akt -- antagonists & inhibitors KW - Epidermal Growth Factor -- metabolism KW - Cell Adhesion KW - Phosphatidylinositol Phosphates -- biosynthesis KW - Phosphoproteins -- chemistry KW - Phosphatidylinositol Phosphates -- metabolism KW - Blood Proteins -- chemistry KW - Blood Proteins -- metabolism KW - Phosphoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68679933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cell+science&rft.atitle=Selective+cellular+effects+of+overexpressed+pleckstrin-homology+domains+that+recognize+PtdIns%283%2C4%2C5%29P3+suggest+their+interaction+with+protein+binding+partners.&rft.au=V%C3%A1rnai%2C+P%C3%A9ter%3BBondeva%2C+Tzvetanka%3BTam%C3%A1s%2C+P%C3%A9ter%3BT%C3%B3th%2C+Bal%C3%A1zs%3BBuday%2C+L%C3%A1szl%C3%B3%3BHunyady%2C+L%C3%A1szl%C3%B3%3BBalla%2C+Tamas&rft.aulast=V%C3%A1rnai&rft.aufirst=P%C3%A9ter&rft.date=2005-10-15&rft.volume=118&rft.issue=&rft.spage=4879&rft.isbn=&rft.btitle=&rft.title=Journal+of+cell+science&rft.issn=00219533&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-24 N1 - Date created - 2005-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mutations in dopachrome tautomerase (Dct) affect eumelanin/pheomelanin synthesis, but do not affect intracellular trafficking of the mutant protein. AN - 68669845; 15960609 AB - Dopachrome tautomerase (Dct) is a type I membrane protein and an important regulatory enzyme that plays a pivotal role in the biosynthesis of melanin and in the rapid metabolism of its toxic intermediates. Dct-mutant melanocytes carrying the slaty or slaty light mutations were derived from the skin of newborn congenic C57BL/6J non-agouti black mice and were used to study the effect(s) of these mutations on the intracellular trafficking of Dct and on the pigmentation of the cells. Dct activity is 3-fold lower in slaty cells compared with non-agouti black melanocytes, whereas slaty light melanocytes have a surprisingly 28-fold lower Dct activity. Homology modelling of the active site of Dct suggests that the slaty mutation [R194Q (Arg194-->Gln)] is located in the active site and may alter the ability of the enzyme to transform the substrate. Transmembrane prediction methods indicate that the slaty light mutation [G486R (Gly486-->Arg)] may result in the sliding of the transmembrane domain towards the N-terminus, thus interfering with Dct function. Chemical analysis showed that both Dct mutations increase pheomelanin and reduce eumelanin produced by melanocytes in culture. Thus the enzymatic activity of Dct may play a role in determining whether the eumelanin or pheomelanin pathway is preferred for pigment biosynthesis. JF - The Biochemical journal AU - Costin, Gertrude-E AU - Valencia, Julio C AU - Wakamatsu, Kazumasa AU - Ito, Shosuke AU - Solano, Francisco AU - Milac, Adina L AU - Vieira, Wilfred D AU - Yamaguchi, Yuji AU - Rouzaud, François AU - Petrescu, Andrei-J AU - Lamoreux, M Lynn AU - Hearing, Vincent J AD - Pigment Cell Biology Section, Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD 20892, USA. Y1 - 2005/10/15/ PY - 2005 DA - 2005 Oct 15 SP - 249 EP - 259 VL - 391 KW - Melanins KW - 0 KW - pheomelanin KW - eumelanin KW - 12627-86-0 KW - Intramolecular Oxidoreductases KW - EC 5.3.- KW - dopachrome isomerase KW - EC 5.3.3.12 KW - Index Medicus KW - Animals KW - Gene Expression Regulation, Enzymologic KW - Cells, Cultured KW - Molecular Sequence Data KW - Mice KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - Protein Transport KW - Protein Conformation KW - Binding Sites KW - Melanins -- biosynthesis KW - Intramolecular Oxidoreductases -- genetics KW - Melanocytes -- metabolism KW - Intramolecular Oxidoreductases -- metabolism KW - Melanocytes -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68669845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Biochemical+journal&rft.atitle=Mutations+in+dopachrome+tautomerase+%28Dct%29+affect+eumelanin%2Fpheomelanin+synthesis%2C+but+do+not+affect+intracellular+trafficking+of+the+mutant+protein.&rft.au=Costin%2C+Gertrude-E%3BValencia%2C+Julio+C%3BWakamatsu%2C+Kazumasa%3BIto%2C+Shosuke%3BSolano%2C+Francisco%3BMilac%2C+Adina+L%3BVieira%2C+Wilfred+D%3BYamaguchi%2C+Yuji%3BRouzaud%2C+Fran%C3%A7ois%3BPetrescu%2C+Andrei-J%3BLamoreux%2C+M+Lynn%3BHearing%2C+Vincent+J&rft.aulast=Costin&rft.aufirst=Gertrude-E&rft.date=2005-10-15&rft.volume=391&rft.issue=&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=The+Biochemical+journal&rft.issn=1470-8728&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-26 N1 - Date created - 2005-10-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Hered. 1963 Mar-Apr;54:47-50 [13943454] Nucleic Acids Res. 1988 Nov 25;16(22):10881-90 [2849754] J Biol Chem. 2000 Mar 17;275(11):8169-75 [10713140] J Mol Biol. 2000 Jun 2;299(2):499-520 [10860755] Bioinformatics. 2000 Apr;16(4):404-5 [10869041] Pigment Cell Res. 2000 Oct;13(5):364-74 [11041214] Pigment Cell Res. 2000;13 Suppl 8:103-9 [11041366] J Mol Biol. 2001 Jan 19;305(3):567-80 [11152613] Pigment Cell Res. 2001 Feb;14(1):23-31 [11277491] Biochem J. 2001 Apr 15;355(Pt 2):259-69 [11284711] Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10698-703 [11526213] FASEB J. 2001 Oct;15(12):2149-61 [11641241] Proteins. 2002 May 1;47(2):228-35 [11933069] Pigment Cell Res. 2002 Jun;15(3):174-83 [12028581] J Cell Sci. 2003 Aug 1;116(Pt 15):3203-12 [12829739] Pigment Cell Res. 2003 Aug;16(4):333-44 [12859616] Glycobiology. 2004 Feb;14(2):103-14 [14514716] Mol Cell Biol. 2004 Apr;24(8):3396-403 [15060160] Science. 1969 May 16;164(3881):838-9 [4976615] Biochem J. 1976 Sep 1;157(3):549-57 [825109] J Invest Dermatol. 1980 Aug;75(2):192-5 [6774031] J Cell Biol. 1982 Apr;93(1):97-102 [7068762] Biochim Biophys Acta. 1987 Aug 13;925(2):203-9 [3113493] J Biol Chem. 1989 Feb 25;264(6):3397-403 [2492536] Cell. 1990 Jun 29;61(7):1349-57 [2194670] J Cutan Pathol. 1991 Dec;18(6):432-5 [1774353] EMBO J. 1992 Feb;11(2):519-26 [1537333] EMBO J. 1992 Feb;11(2):527-35 [1537334] Biochim Biophys Acta. 1994 Apr 28;1221(3):272-8 [8167148] J Invest Dermatol. 1994 Aug;103(2):196-201 [8040609] Biochem Biophys Res Commun. 1994 Jul 29;202(2):1060-8 [8048919] Proteins. 1994 May;19(1):55-72 [8066087] Pigment Cell Res. 1994 Jun;7(3):141-4 [7971746] Comput Appl Biosci. 1994 Dec;10(6):685-6 [7704669] J Invest Dermatol. 1995 Sep;105(3):361-6 [7665913] Genomics. 1995 Sep 1;29(1):35-43 [8530099] Biochem J. 1996 Jan 15;313 ( Pt 2):447-53 [8573077] Pigment Cell Res. 1996 Oct;9(5):265-70 [9014213] EMBO J. 1997 Jun 16;16(12):3544-52 [9218796] J Invest Dermatol. 1997 Aug;109(2):207-12 [9242509] Protein Eng. 1997 Jun;10(6):673-6 [9278280] Biochem Biophys Res Commun. 1998 Jan 26;242(3):579-85 [9464259] Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7374-8 [9636156] Bioinformatics. 1998;14(10):846-56 [9927713] Anal Biochem. 2004 Dec 1;335(1):171-4 [15519586] J Chromatogr. 1987 Sep 25;420(2):404-10 [3693511] Biochem Biophys Res Commun. 2005 Mar 25;328(4):914-21 [15707965] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Invited Commentary: Why DDT matters now. AN - 68639666; 16120697 JF - American journal of epidemiology AU - Longnecker, Matthew P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. longnec1@niehs.nih.gov Y1 - 2005/10/15/ PY - 2005 DA - 2005 Oct 15 SP - 726 EP - 728 VL - 162 IS - 8 SN - 0002-9262, 0002-9262 KW - Biomarkers KW - 0 KW - DDT KW - CIW5S16655 KW - Index Medicus KW - Maternal Exposure -- adverse effects KW - Global Health KW - Humans KW - Infant, Newborn KW - Incidence KW - Biomarkers -- blood KW - Female KW - Pregnancy KW - DDT -- blood KW - Pregnancy Complications -- chemically induced KW - DDT -- adverse effects KW - Birth Weight -- drug effects KW - Pregnancy Complications -- blood KW - Environmental Exposure -- adverse effects KW - Pregnancy Complications -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68639666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Invited+Commentary%3A+Why+DDT+matters+now.&rft.au=Longnecker%2C+Matthew+P&rft.aulast=Longnecker&rft.aufirst=Matthew&rft.date=2005-10-15&rft.volume=162&rft.issue=8&rft.spage=726&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-01 N1 - Date created - 2005-10-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Am J Epidemiol. 2005 Oct 15;162(8):709-16 [16120699] Am J Epidemiol. 2005 Oct 15;162(8):717-25 [16120698] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prooxidant activity of resveratrol in the presence of copper ions: mutagenicity in plasmid DNA. AN - 68596064; 15913925 AB - Resveratrol, a polyphenolic compound of plant origin, has been of much interest to researchers because of its anticancer and cardiovascular properties. Although antioxidant action of this compound is believed responsible for its reported properties, it has also been shown to exhibit prooxidant properties, especially in the presence of copper ions. Here we report the mutagenicity of resveratrol in plasmid DNA. Plasmid bluescript SK(+) DNA was treated with increasing concentrations of resveratrol in the presence and absence of copper ions, transformed into competent DH5alpha cells and sequenced. We looked for mutations caused by resveratrol treatment by comparing the sequences of treated plasmids versus control (untreated plasmid). The results show a decrease in the transformation efficiency of the plasmid after resveratrol treatment, and although all types of mutations were recorded, point mutations (deletions/substitutions) were found to be the predominant ones. Resveratrol alone resulted in deletion of mainly guanine bases. Since copper ions are known to be found in the nucleus, bound to guanine bases in chromatin, our results suggest mobilization of such endogenous copper by resveratrol resulting in prooxidant DNA cleavage at the site. Concentration of copper is reported to be elevated in various malignancies and the present studies might explain the reported anticancer activity of resveratrol in various cancer cell lines. JF - Toxicology letters AU - Ahmad, Aamir AU - Syed, Farhan Asad AU - Singh, Saurabh AU - Hadi, S M AD - Department of Biochemistry, Faculty of Life Sciences, AMU, Aligarh, UP 202002, India. ahmada@mail.nih.gov Y1 - 2005/10/15/ PY - 2005 DA - 2005 Oct 15 SP - 1 EP - 12 VL - 159 IS - 1 SN - 0378-4274, 0378-4274 KW - Antineoplastic Agents, Phytogenic KW - 0 KW - Mutagens KW - Oxidants KW - Stilbenes KW - Guanine KW - 5Z93L87A1R KW - Copper KW - 789U1901C5 KW - DNA KW - 9007-49-2 KW - resveratrol KW - Q369O8926L KW - Index Medicus KW - Lac Operon -- genetics KW - Spectrometry, Fluorescence KW - Guanine -- chemistry KW - DNA Mutational Analysis KW - Apoptosis -- drug effects KW - Escherichia coli -- drug effects KW - Escherichia coli -- genetics KW - Gene Deletion KW - DNA Damage -- drug effects KW - DNA -- isolation & purification KW - Antineoplastic Agents, Phytogenic -- toxicity KW - Plasmids -- genetics KW - DNA -- genetics KW - Stilbenes -- toxicity KW - Plasmids -- drug effects KW - Copper -- chemistry KW - DNA -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68596064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Prooxidant+activity+of+resveratrol+in+the+presence+of+copper+ions%3A+mutagenicity+in+plasmid+DNA.&rft.au=Ahmad%2C+Aamir%3BSyed%2C+Farhan+Asad%3BSingh%2C+Saurabh%3BHadi%2C+S+M&rft.aulast=Ahmad&rft.aufirst=Aamir&rft.date=2005-10-15&rft.volume=159&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=03784274&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-09 N1 - Date created - 2005-09-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Synthesis and evaluation of antioxidative properties of a series of organoselenium compounds. AN - 68554328; 16019215 AB - A series of organoselenocyanate compounds 4a-d were synthesized utilizing 1,8-naphthalic anhydride as the building unit. These compounds were evaluated for their antioxidative activities against DMBA-PMA-induced oxidative stress in a two-stage mouse skin carcinogenic model. Compound 4d was found to have the maximum antioxidative property in comparison with the other compounds. Also, the pretreatment group showed better results than the concomitant treatment groups. JF - Bioorganic & medicinal chemistry AU - Hossain, Sk Ugir AU - Sengupta, Sumitra AU - Bhattacharya, Sudin AD - Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, 37, SP Mukherjee Road, Kolkata 700 026, India. Y1 - 2005/10/15/ PY - 2005 DA - 2005 Oct 15 SP - 5750 EP - 5758 VL - 13 IS - 20 SN - 0968-0896, 0968-0896 KW - Antioxidants KW - 0 KW - Organoselenium Compounds KW - Index Medicus KW - Animals KW - Microsomes, Liver -- drug effects KW - Mice KW - Lipid Peroxidation KW - Spectrometry, Mass, Fast Atom Bombardment KW - Female KW - Magnetic Resonance Spectroscopy KW - Organoselenium Compounds -- pharmacology KW - Antioxidants -- chemical synthesis KW - Antioxidants -- pharmacology KW - Organoselenium Compounds -- chemical synthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68554328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+%26+medicinal+chemistry&rft.atitle=Synthesis+and+evaluation+of+antioxidative+properties+of+a+series+of+organoselenium+compounds.&rft.au=Hossain%2C+Sk+Ugir%3BSengupta%2C+Sumitra%3BBhattacharya%2C+Sudin&rft.aulast=Hossain&rft.aufirst=Sk&rft.date=2005-10-15&rft.volume=13&rft.issue=20&rft.spage=5750&rft.isbn=&rft.btitle=&rft.title=Bioorganic+%26+medicinal+chemistry&rft.issn=09680896&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-22 N1 - Date created - 2005-09-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Absence of acrylamide-induced genotoxicity in CYP2E1-null mice: Evidence consistent with a glycidamide-mediated effect AN - 20830616; 6523789 AB - Acrylamide, an animal carcinogen and germ cell mutagen present at low (ppm) levels in heated carbohydrate-containing foodstuffs, is oxidized by cytochrome P4502E1 (CYP2E1) to the epoxide glycidamide, which is believed to be responsible for the mutagenic and carcinogenic activity of acrylamide. We recently reported a comparison of the effects of acrylamide on the genetic integrity of germ cells of male wild-type and CYP2E1-null mice [B.I. Ghanayem, K.L. Witt, L. El-Hadri, U. Hoffler, G.E. Kissling, M.D. Shelby, J.B. Bishop, Comparison of germ-cell mutagenicity in male CYP2E1-null and wild-type mice treated with acrylamide: evidence supporting a glycidamide-mediated effect, Biol. Reprod. 72 (2005) 157-163]. In those experiments, dose-related increases in dominant lethal mutations were detected in uterine contents of female mice mated to acrylamide-treated wild-type males but not CYP2E1-null males, clearly implicating CYP2E1-mediated formation of glycidamide in the induction of genetic damage in male germ cells. We hypothesized that acrylamide-induced somatic cell damage is also caused by glycidamide. Therefore, to examine this hypothesis, female wild-type and CYP2E1-null mice were administered acrylamide (0, 25, 50mg/kg) by intraperitoneal injection once daily for 5 consecutive days. Twenty-four hours after the final treatment, blood and tissue samples were collected. Erythrocyte micronucleus frequencies were determined using flow cytometry and DNA damage was assessed in leukocytes, liver, and lung using the alkaline (pH>13) single cell gel electrophoresis (Comet) assay. Results were consistent with the earlier observations in male germ cells: significant dose-related increases in micronucleated erythrocytes and DNA damage in somatic cells were induced in acrylamide-treated wild-type but not in the CYP2E1-null mice. These results support the hypothesis that genetic damage in somatic and germ cells of mice-treated with acrylamide is dependent upon metabolism of the parent compound by CYP2E1. This dependency on metabolism has implications for the assessment of human risks resulting from occupational or dietary exposure to acrylamide. CYP2E1 polymorphisms and variability in CYP2E1 activity associated with, for example, diabetes, obesity, starvation, and alcohol consumption, may result in altered metabolic efficiencies leading to differential susceptibilities to acrylamide toxicities in humans. JF - Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis AU - Ghanayem, B I AU - Witt, K L AU - Kissling, GE AU - Tice, R R AU - Recio, L AD - National Institute of Environmental Health Sciences, National Institutes of Health, P.O. Box 12233, Research Triangle Park, NC 27709, USA, ghanayem@niehs.nih.gov Y1 - 2005/10/15/ PY - 2005 DA - 2005 Oct 15 SP - 284 EP - 297 VL - 578 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Genetics Abstracts; Toxicology Abstracts KW - Risk assessment KW - Mutagens KW - Molecular modelling KW - Epoxides KW - Food KW - Erythrocytes KW - Carcinogens KW - Somatic cells KW - Mutagenesis KW - Flow cytometry KW - Occupational exposure KW - Ethanol KW - Starvation KW - Obesity KW - Uterus KW - Mutagenicity KW - Leukocytes KW - Genotoxicity KW - Germ cells KW - Toxicity KW - Gel electrophoresis KW - Diabetes mellitus KW - DNA damage KW - Blood KW - Acrylamide KW - Lung KW - Liver KW - Comet assay KW - Mutation KW - Metabolism KW - X 24120:Food, additives & contaminants KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20830616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research-Fundamental+and+Molecular+Mechanisms+of+Mutagenesis&rft.atitle=Absence+of+acrylamide-induced+genotoxicity+in+CYP2E1-null+mice%3A+Evidence+consistent+with+a+glycidamide-mediated+effect&rft.au=Ghanayem%2C+B+I%3BWitt%2C+K+L%3BKissling%2C+GE%3BTice%2C+R+R%3BRecio%2C+L&rft.aulast=Ghanayem&rft.aufirst=B&rft.date=2005-10-15&rft.volume=578&rft.issue=1-2&rft.spage=284&rft.isbn=&rft.btitle=&rft.title=Mutation+Research-Fundamental+and+Molecular+Mechanisms+of+Mutagenesis&rft.issn=00275107&rft_id=info:doi/10.1016%2Fj.mrfmmm.2005.05.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-01-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Risk assessment; Molecular modelling; Mutagens; Epoxides; Food; Erythrocytes; Carcinogens; Somatic cells; Mutagenesis; Flow cytometry; Occupational exposure; Ethanol; Starvation; Obesity; Mutagenicity; Uterus; Genotoxicity; Leukocytes; Germ cells; Toxicity; Gel electrophoresis; Diabetes mellitus; Blood; DNA damage; Acrylamide; Lung; Liver; Comet assay; Mutation; Metabolism DO - http://dx.doi.org/10.1016/j.mrfmmm.2005.05.004 ER - TY - JOUR T1 - Measuring Fifteen Endogenous Estrogens Simultaneously in Human Urine by High-Performance Liquid Chromatography-Mass Spectrometry AN - 19419636; 6538323 AB - A sensitive, specific, accurate, and precise high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry method for measuring the absolute quantities of 15 endogenous estrogens and their metabolites in human urine has been developed and validated. The method requires a single hydrolysis/extraction/derivatization step and only 0.5 mL of urine, yet is capable of simultaneously quantifying estrone and its 2-, 4-methoxy and 2-, 4-, and 16 alpha -hydroxy derivatives, and 2-hydroxyestrone-3-methyl ether; estradiol and its 2-, 4-methoxy and 2-, 16 alpha -hydroxy derivatives, 16-epiestriol, 17-epiestriol, and 16-ketoestradiol in pre- and postmenopausal women as well as men. Standard curves are linear over a 10 super(3)-fold concentration range with the standard error of the estimate (SEE) and the relative standard error of the estimate (RSEE) for the linear regression line ranging from 0.0131 to 0.1760 and 1.2 to 7.3%, respectively. The lower limit of quantitation for each estrogen is 0.02 ng/0.5 mL urine sample (2 pg on column), with the percent recovery of a known added amount of compound (accuracy) of 96-107% and an overall precision, including the hydrolysis, extraction, and derivatization steps, of 1-5% relative standard deviation (RSD) for samples prepared concurrently and 1-12% RSD for samples prepared in separate batches. Since individual patterns of estrogen metabolism may influence the risk of breast cancer, accurate, precise, and specific measurement of endogenous estrogen metabolites in biological matrixes will facilitate future research on breast cancer prevention, screening, and treatment. JF - Analytical Chemistry (Washington) AU - Xu, X AU - Veenstra, T D AU - Fox, S D AU - Roman, J M AU - Issaq, HJ AU - Falk, R AU - Saavedra, JE AU - Keefer, L K AU - Ziegler, R G AD - Laboratory of Proteomics and Analytical Technologies, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland 21702, USA Y1 - 2005/10/15/ PY - 2005 DA - 2005 Oct 15 SP - 6646 EP - 6654 VL - 77 IS - 20 SN - 0003-2700, 0003-2700 KW - Biotechnology and Bioengineering Abstracts KW - Estrogens KW - Metabolites KW - Hydrolysis KW - Mass spectroscopy KW - Estradiol KW - Spectrometry KW - Standard deviation KW - Post-menopause KW - Urine KW - Breast cancer KW - Ethers KW - Quantitation KW - Metabolism KW - Estrone KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19419636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Chemistry+%28Washington%29&rft.atitle=Measuring+Fifteen+Endogenous+Estrogens+Simultaneously+in+Human+Urine+by+High-Performance+Liquid+Chromatography-Mass+Spectrometry&rft.au=Xu%2C+X%3BVeenstra%2C+T+D%3BFox%2C+S+D%3BRoman%2C+J+M%3BIssaq%2C+HJ%3BFalk%2C+R%3BSaavedra%2C+JE%3BKeefer%2C+L+K%3BZiegler%2C+R+G&rft.aulast=Xu&rft.aufirst=X&rft.date=2005-10-15&rft.volume=77&rft.issue=20&rft.spage=6646&rft.isbn=&rft.btitle=&rft.title=Analytical+Chemistry+%28Washington%29&rft.issn=00032700&rft_id=info:doi/10.1021%2Fac050697c LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Estrogens; Urine; Hydrolysis; Breast cancer; Metabolites; Estradiol; Spectrometry; Ethers; Standard deviation; Mass spectroscopy; Post-menopause; Metabolism; Estrone; Quantitation DO - http://dx.doi.org/10.1021/ac050697c ER - TY - JOUR T1 - Identification of an agonist-induced conformational change occurring adjacent to the ligand-binding pocket of the M(3) muscarinic acetylcholine receptor. AN - 68673487; 16093246 AB - To study the conformational changes that convert G protein-coupled receptors (GPCRs) from their resting to their active state, we used the M(3) muscarinic acetylcholine receptor, a prototypical class A GPCR, as a model system. Specifically, we employed a recently developed in situ disulfide cross-linking strategy that allows the formation of disulfide bonds in Cys-substituted mutant M(3) muscarinic receptors present in their native membrane environment. At present, little is known about the conformational changes that GPCR ligands induce in the immediate vicinity of the ligand-binding pocket. To address this issue, we generated 11 Cys-substituted mutant M(3) muscarinic receptors and characterized these receptors in transfected COS-7 cells. All analyzed mutant receptors contained an endogenous Cys residue (Cys-532(7.42)) located within the exofacial segment of transmembrane domain (TM) VII, close to the agonist-binding site. In addition, all mutant receptors harbored a second Cys residue that was introduced into the exofacial segment of TM III, within the sequence Leu-142(3.27)-Asn-152(3.37). Disulfide cross-linking studies showed that muscarinic agonists, but not antagonists, promoted the formation of a disulfide bond between S151(3.36)C and Cys-532. A three-dimensional model of the inactive state of the M(3) muscarinic receptor indicated that Cys-532 and Ser-151 face each other in the center of the TM receptor core. Our cross-linking data therefore support the concept that agonist activation pulls the exofacial segments of TMs VII and III closer to each other. This structural change may represent one of the early conformational events triggering the more pronounced structural reorganization of the intracellular receptor surface. To the best of our knowledge, this is the first direct demonstration of a conformational change occurring in the immediate vicinity of the binding site of a GPCR activated by a diffusible ligand. JF - The Journal of biological chemistry AU - Han, Sung-Jun AU - Hamdan, Fadi F AU - Kim, Soo-Kyung AU - Jacobson, Kenneth A AU - Bloodworth, Lanh M AU - Li, Bo AU - Wess, Jürgen AD - Molecular Signaling and Molecular Recognition Sections, Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-0810, USA. Y1 - 2005/10/14/ PY - 2005 DA - 2005 Oct 14 SP - 34849 EP - 34858 VL - 280 IS - 41 SN - 0021-9258, 0021-9258 KW - Cross-Linking Reagents KW - 0 KW - Disulfides KW - Ligands KW - Phosphatidylinositols KW - Receptors, Muscarinic KW - Serine KW - 452VLY9402 KW - Asparagine KW - 7006-34-0 KW - Carbachol KW - 8Y164V895Y KW - Luciferases KW - EC 1.13.12.- KW - Leucine KW - GMW67QNF9C KW - Cysteine KW - K848JZ4886 KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Phosphatidylinositols -- chemistry KW - Animals KW - COS Cells KW - Leucine -- chemistry KW - Carbachol -- chemistry KW - Rats KW - Mutagenesis, Site-Directed KW - Cysteine -- chemistry KW - Molecular Sequence Data KW - Protein Conformation KW - Dose-Response Relationship, Drug KW - Models, Molecular KW - Cross-Linking Reagents -- pharmacology KW - Luciferases -- metabolism KW - Amino Acid Sequence KW - Protein Binding KW - Serine -- chemistry KW - Binding Sites KW - Blotting, Western KW - Disulfides -- chemistry KW - Transfection KW - Kinetics KW - Cercopithecus aethiops KW - Oxygen -- chemistry KW - Models, Chemical KW - Cell Membrane -- metabolism KW - Protein Structure, Tertiary KW - Carbachol -- pharmacology KW - Mutation KW - Asparagine -- chemistry KW - Receptors, Muscarinic -- chemistry KW - Receptors, Muscarinic -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68673487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Identification+of+an+agonist-induced+conformational+change+occurring+adjacent+to+the+ligand-binding+pocket+of+the+M%283%29+muscarinic+acetylcholine+receptor.&rft.au=Han%2C+Sung-Jun%3BHamdan%2C+Fadi+F%3BKim%2C+Soo-Kyung%3BJacobson%2C+Kenneth+A%3BBloodworth%2C+Lanh+M%3BLi%2C+Bo%3BWess%2C+J%C3%BCrgen&rft.aulast=Han&rft.aufirst=Sung-Jun&rft.date=2005-10-14&rft.volume=280&rft.issue=41&rft.spage=34849&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-13 N1 - Date created - 2005-10-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Whole-Body Hypothermia for Neonates with Hypoxic-Ischemic Encephalopathy AN - 223942405; 16221780 AB - Background Hypothermia is protective against brain injury after asphyxiation in animal models. However, the safety and effectiveness of hypothermia in term infants with encephalopathy is uncertain. Methods We conducted a randomized trial of hypothermia in infants with a gestational age of at least 36 weeks who were admitted to the hospital at or before six hours of age with either severe acidosis or perinatal complications and resuscitation at birth and who had moderate or severe encephalopathy. Infants were randomly assigned to usual care (control group) or whole-body cooling to an esophageal temperature of 33.5°C for 72 hours, followed by slow rewarming (hypothermia group). Neurodevelopmental outcome was assessed at 18 to 22 months of age. The primary outcome was a combined end point of death or moderate or severe disability. Results Of 239 eligible infants, 102 were assigned to the hypothermia group and 106 to the control group. Adverse events were similar in the two groups during the 72 hours of cooling. Primary outcome data were available for 205 infants. Death or moderate or severe disability occurred in 45 of 102 infants (44 percent) in the hypothermia group and 64 of 103 infants (62 percent) in the control group (risk ratio, 0.72; 95 percent confidence interval, 0.54 to 0.95; P=0.01). Twenty-four infants (24 percent) in the hypothermia group and 38 (37 percent) in the control group died (risk ratio, 0.68; 95 percent confidence interval, 0.44 to 1.05; P=0.08). There was no increase in major disability among survivors; the rate of cerebral palsy was 15 of 77 (19 percent) in the hypothermia group as compared with 19 of 64 (30 percent) in the control group (risk ratio, 0.68; 95 percent confidence interval, 0.38 to 1.22; P=0.20). Conclusions Whole-body hypothermia reduces the risk of death or disability in infants with moderate or severe hypoxic-ischemic encephalopathy. JF - The New England Journal of Medicine AU - Shankaran, Seetha, MD AU - Laptook, Abbot R, MD AU - Ehrenkranz, Richard A, MD AU - Tyson, Jon E, MD, MPH AU - McDonald, Scott A, BS AU - Donovan, Edward F, MD AU - Fanaroff, Avroy A, MD AU - Poole, W Kenneth, PhD AU - Wright, Linda L, MD AU - Higgins, Rosemary D, MD AU - Finer, Neil N, MD AU - Carlo, Waldemar A, MD AU - Duara, Shahnaz, MD AU - Oh, William, MD AU - Cotten, C Michael, MD AU - Stevenson, David K, MD AU - Stoll, Barbara J, MD AU - Lemons, James A, MD AU - Guillet, Ronnie, MD, PhD AU - Jobe, Alan H, MD, PhD Y1 - 2005/10/13/ PY - 2005 DA - 2005 Oct 13 SP - 1574 EP - 84 CY - Boston PB - Massachusetts Medical Society VL - 353 IS - 15 SN - 00284793 KW - Medical Sciences KW - Babies KW - Brain damage KW - Age KW - Cooling KW - Nitric oxide KW - Ischemia KW - Brain research KW - Consciousness KW - Consent KW - Intensive care KW - Pregnancy Complications KW - Asphyxia Neonatorum -- complications KW - Hypoxia-Ischemia, Brain -- mortality KW - Blindness -- prevention & control KW - Humans KW - Infant, Newborn KW - Obstetric Labor Complications KW - Pregnancy KW - Hearing Loss -- prevention & control KW - Acidosis -- etiology KW - Follow-Up Studies KW - Hypoxia-Ischemia, Brain -- complications KW - Female KW - Male KW - Cerebral Palsy -- prevention & control KW - Developmental Disabilities -- prevention & control KW - Hypoxia-Ischemia, Brain -- therapy KW - Hypothermia, Induced -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/223942405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+Journal+of+Medicine&rft.atitle=Whole-Body+Hypothermia+for+Neonates+with+Hypoxic-Ischemic+Encephalopathy&rft.au=Shankaran%2C+Seetha%2C+MD%3BLaptook%2C+Abbot+R%2C+MD%3BEhrenkranz%2C+Richard+A%2C+MD%3BTyson%2C+Jon+E%2C+MD%2C+MPH%3BMcDonald%2C+Scott+A%2C+BS%3BDonovan%2C+Edward+F%2C+MD%3BFanaroff%2C+Avroy+A%2C+MD%3BPoole%2C+W+Kenneth%2C+PhD%3BWright%2C+Linda+L%2C+MD%3BHiggins%2C+Rosemary+D%2C+MD%3BFiner%2C+Neil+N%2C+MD%3BCarlo%2C+Waldemar+A%2C+MD%3BDuara%2C+Shahnaz%2C+MD%3BOh%2C+William%2C+MD%3BCotten%2C+C+Michael%2C+MD%3BStevenson%2C+David+K%2C+MD%3BStoll%2C+Barbara+J%2C+MD%3BLemons%2C+James+A%2C+MD%3BGuillet%2C+Ronnie%2C+MD%2C+PhD%3BJobe%2C+Alan+H%2C+MD%2C+PhD&rft.aulast=Shankaran&rft.aufirst=Seetha&rft.date=2005-10-13&rft.volume=353&rft.issue=15&rft.spage=1574&rft.isbn=&rft.btitle=&rft.title=The+New+England+Journal+of+Medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright © 2005 Massachusetts Medical Society. All rights reserved. N1 - Document feature - Tables; Graphs; References N1 - Last updated - 2014-04-29 N1 - CODEN - NEJMAG ER - TY - JOUR T1 - Influence of nonameric AU-rich tristetraprolin-binding sites on mRNA deadenylation and turnover. AN - 68646264; 16061475 AB - Tristetraprolin (TTP), a member of the tandem CCCH zinc finger protein family, promotes deadenylation of tumor necrosis factor-alpha and granulocyte-macrophage colony-stimulating factor mRNAs after binding to the AU-rich elements (ARE) in their 3'-untranslated regions. The high affinity TTP-ARE binding occurs between the tandem zinc finger domain and the preferred nonamer UUAUUUAUU. By mutating a well defined core sequence of 24 bases from the tumor necrosis factor-alpha ARE, we compared the influence of four possible nonameric TTP-binding sites in the wild-type ARE with that of a single binding site in the mutated probe on the binding of TTP to the RNA and the subsequent deadenylation of the poly(A) tail. By inserting this 24-base ARE into an otherwise stable transcript, we also attempted to determine the extent of the instability conferred by the presence of one or two TTP-binding sites. These sites were created or modified by mutating the As in the UUAUUUAUU nonamer or by changing the central U in the nonamer, in both cases to C residues. The results suggest that even a single nonamer TTP-binding site can confer at least partial sensitivity to the TTP-mediated mRNA turnover on an otherwise stable mRNA, but that two binding sites make the transcript much more unstable. Even though the central U of the nonamer binding site was predicted by structural studies possibly to permit base substitution, mutation of this U to C greatly inhibited the binding of TTP to the ARE, thus reducing the ability of the TTP to promote deadenylation and instability of the mRNA. JF - The Journal of biological chemistry AU - Lai, Wi S AU - Carrick, Danielle M AU - Blackshear, Perry J AD - Laboratory of Neurobiology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2005/10/07/ PY - 2005 DA - 2005 Oct 07 SP - 34365 EP - 34377 VL - 280 IS - 40 SN - 0021-9258, 0021-9258 KW - RNA, Messenger KW - 0 KW - Tristetraprolin KW - Uracil KW - 56HH86ZVCT KW - Adenine KW - JAC85A2161 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Base Sequence KW - Genomic Instability KW - Molecular Sequence Data KW - Binding Sites -- physiology KW - RNA, Messenger -- metabolism KW - Tristetraprolin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68646264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Influence+of+nonameric+AU-rich+tristetraprolin-binding+sites+on+mRNA+deadenylation+and+turnover.&rft.au=Lai%2C+Wi+S%3BCarrick%2C+Danielle+M%3BBlackshear%2C+Perry+J&rft.aulast=Lai&rft.aufirst=Wi&rft.date=2005-10-07&rft.volume=280&rft.issue=40&rft.spage=34365&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-02 N1 - Date created - 2005-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anthrax Biosensor, Protective Antigen Ion Channel Asymmetric Blockade AN - 17393875; 6503357 AB - The significant threat posed by biological agents (e.g. anthrax, tetanus, botulinum, and diphtheria toxins) requires innovative technologies and approaches to understand the mechanisms of toxin action and to develop better therapies. Anthrax toxins are formed from three proteins secreted by fully virulent Bacillus anthracis, protective antigen (PA, 83 kDa), lethal factor (LF, 90 kDa), and edema factor (EF, 89 kDa). Here we present electrophysiological measurements demonstrating that full-length LF and EF convert the current-voltage relationship of the heptameric PA sub(63) ion channel from slightly nonlinear to highly rectifying and diode-like at pH 6.6. This effect provides a novel method for characterizing functional toxin interactions. The method confirms that a previously well characterized PA sub(63) monoclonal antibody, which neutralizes anthrax lethal toxin in animals in vivo and in vitro, prevents the binding of LF to the PA sub(63) pore. The technique can also detect the presence of anthrax lethal toxin complex from plasma of infected animals. The latter two results suggest the potential application of PA sub(63) nanopore-based biosensors in anthrax therapeutics and diagnostics. JF - Journal of Biological Chemistry AU - Halverson, Kelly M AU - Panchal, Rekha G AU - Nguyen, Tam L AU - Gussio, Rick AU - Little, Stephen F AU - Misakian, Martin AU - Bavari, Sina AU - Kasianowicz, John J AD - United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702-5011, Developmental Therapeutics Program, Target Structure-based Drug Discovery Group, National Cancer Institute-Science Applications International Corporation, Frederick, Maryland 21702, National Institute of Standards and Technology, Electronics and Electrical Engineering Laboratory, Gaithersburg, Maryland 20899-8172, and National Institute of Standards and Technology, Advanced Chemical Sciences Laboratory and the Electronics and Electrical Engineering Laboratory, Semiconductor Engineering Division, Gaithersburg, Maryland 20899-8120 Y1 - 2005/10/07/ PY - 2005 DA - 2005 Oct 07 SP - 34056 EP - 34062 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 280 IS - 40 SN - 0021-9258, 0021-9258 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology; Bioengineering Abstracts KW - Anthrax lethal toxin KW - Channel pores KW - Monoclonal antibodies KW - Lethal factor KW - protective antigen KW - Edema KW - Bacillus anthracis KW - Tetanus KW - Diphtheria toxin KW - Biosensors KW - Ion channels KW - Anthrax KW - pH effects KW - J 02822:Biosynthesis and physicochemical properties KW - W4 140:Bioinformatics & Computers in Health & Medicine KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17393875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Anthrax+Biosensor%2C+Protective+Antigen+Ion+Channel+Asymmetric+Blockade&rft.au=Halverson%2C+Kelly+M%3BPanchal%2C+Rekha+G%3BNguyen%2C+Tam+L%3BGussio%2C+Rick%3BLittle%2C+Stephen+F%3BMisakian%2C+Martin%3BBavari%2C+Sina%3BKasianowicz%2C+John+J&rft.aulast=Halverson&rft.aufirst=Kelly&rft.date=2005-10-07&rft.volume=280&rft.issue=40&rft.spage=34056&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Biosensors; Anthrax lethal toxin; Monoclonal antibodies; Channel pores; Lethal factor; protective antigen; Ion channels; Edema; Anthrax; Tetanus; pH effects; Diphtheria toxin; Bacillus anthracis ER - TY - JOUR T1 - Cumulative Absolute Breast Cancer Risk for Young Women Treated for Hodgkin Lymphoma AN - 20716196; 6505273 AB - BACKGROUND: Many women develop breast cancer after treatment for Hodgkin lymphoma (HL) at a young age. We estimated this future risk, taking into account age and calendar year of HL diagnosis, HL treatment information, population breast cancer incidence rates, and competing causes of death. METHODS: Relative risks of breast cancer for categories defined by radiation dose to the chest (0, 20-<40 Gy, or greater than or equal to 40 Gy) and use of alkylating agents (yes or no) were estimated from a case-control study conducted within an international population-based cohort of 3817 female 1-year survivors of HL diagnosed at age 30 years or younger from January 1, 1965, through December 31, 1994. To compute cumulative absolute risks of breast cancer, we used modified standardized incidence ratios to relate cohort breast cancer risks to those in the general population, enabling application of population-based breast cancer rates, and we allowed for competing risks by using population-based mortality rates in female HL survivors. RESULTS: Cumulative absolute risks of breast cancer increased with age at end of follow-up, time since HL diagnosis, and radiation dose. For an HL survivor who was treated at age 25 years with a chest radiation dose of at least 40 Gy without alkylating agents, estimated cumulative absolute risks of breast cancer by age 35, 45, and 55 years were 1.4% (95% confidence interval [CI] = 0.9% to 2.1%), 11.1% (95% CI = 7.4% to 16.3%), and 29.0% (95% CI = 20.2% to 40.1%), respectively. Cumulative absolute risks were lower in women treated with alkylating agents. CONCLUSIONS: Breast cancer projections varied considerably by type of HL therapy, time since HL diagnosis, and age at end of follow-up. These estimates are applicable to HL survivors treated with regimens of the past and can be used to counsel such patients and plan management and preventive strategies. Projections should be used with caution, however, in patients treated with more recent approaches, including limited-field radiotherapy and/or ovary-sparing chemotherapy. JF - Journal of the National Cancer Institute AU - Travis, Lois B AU - Hill, Deirdre AU - Dores, Graca M AU - Gospodarowicz, Mary AU - van Leeuwen, Flora E AU - Holowaty, Eric AU - Glimelius, Bengt AU - Andersson, Michael AU - Pukkala, Eero AU - Lynch, Charles F AU - Pee, David AU - Smith, Susan A AU - Van't Veer, Mars B AU - Joensuu, Timo AU - Storm, Hans AU - Stovall, Marilyn AU - Boice, John DJr AU - Gilbert, Ethel AU - Gail, Mitchell H AD - Division of Cancer Epidemiology and Genetics (LBT, DH, EG, MHG) and Division of Cancer Prevention (GMD), National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD Y1 - 2005/10/05/ PY - 2005 DA - 2005 Oct 05 SP - 1428 EP - 1437 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 97 IS - 19 SN - 0027-8874, 0027-8874 KW - Risk Abstracts; Immunology Abstracts KW - Alkylating agents KW - Risk assessment KW - Mortality KW - Age KW - Hodgkin's disease KW - Chemotherapy KW - Radiotherapy KW - Chest KW - radiotherapy KW - Cancer KW - chemotherapy KW - Radiation KW - Risk factors KW - risk taking KW - Breast cancer KW - Standards KW - Females KW - lymphoma KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20716196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Cumulative+Absolute+Breast+Cancer+Risk+for+Young+Women+Treated+for+Hodgkin+Lymphoma&rft.au=Travis%2C+Lois+B%3BHill%2C+Deirdre%3BDores%2C+Graca+M%3BGospodarowicz%2C+Mary%3Bvan+Leeuwen%2C+Flora+E%3BHolowaty%2C+Eric%3BGlimelius%2C+Bengt%3BAndersson%2C+Michael%3BPukkala%2C+Eero%3BLynch%2C+Charles+F%3BPee%2C+David%3BSmith%2C+Susan+A%3BVan%27t+Veer%2C+Mars+B%3BJoensuu%2C+Timo%3BStorm%2C+Hans%3BStovall%2C+Marilyn%3BBoice%2C+John+DJr%3BGilbert%2C+Ethel%3BGail%2C+Mitchell+H&rft.aulast=Travis&rft.aufirst=Lois&rft.date=2005-10-05&rft.volume=97&rft.issue=19&rft.spage=1428&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Risk assessment; Alkylating agents; Mortality; Age; Hodgkin's disease; Radiation; Chemotherapy; Risk factors; Radiotherapy; Breast cancer; Chest; risk taking; Standards; Females; radiotherapy; lymphoma; chemotherapy; Cancer ER - TY - JOUR T1 - Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells. AN - 68655455; 16203869 AB - The relative contribution to cytotoxicity of each of the multiple NK cell activation receptors has been difficult to assess. Using Drosophila insect cells, which express ligands of human NK cell receptors, we show that target cell lysis by resting NK cells is controlled by different receptor signals for cytolytic granule polarization and degranulation. Intercellular adhesion molecule (ICAM)-1 on insect cells was sufficient to induce polarization of granules, but not degranulation, in resting NK cells. Conversely, engagement of the Fc receptor CD16 by rabbit IgG on insect cells induced degranulation without specific polarization. Lysis by resting NK cells occurred when polarization and degranulation were induced by the combined presence of ICAM-1 and IgG on insect cells. Engagement of receptor 2B4 by CD48 on insect cells induced weak polarization and no degranulation. However, coengagement of 2B4 and CD16 by their respective ligands resulted in granule polarization and cytotoxicity in the absence of leukocyte functional antigen-1-mediated adhesion to target cells. These data show that cytotoxicity by resting NK cells is controlled tightly by separate or cooperative signals from different receptors for granule polarization and degranulation. JF - The Journal of experimental medicine AU - Bryceson, Yenan T AU - March, Michael E AU - Barber, Domingo F AU - Ljunggren, Hans-Gustaf AU - Long, Eric O AD - Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA. Y1 - 2005/10/03/ PY - 2005 DA - 2005 Oct 03 SP - 1001 EP - 1012 VL - 202 IS - 7 SN - 0022-1007, 0022-1007 KW - Antigens, CD KW - 0 KW - CD244 protein, human KW - DNA Primers KW - Membrane Glycoproteins KW - Receptors, IgG KW - Receptors, Immunologic KW - Signaling Lymphocytic Activation Molecule Family KW - Intercellular Adhesion Molecule-1 KW - 126547-89-5 KW - Index Medicus KW - Animals KW - Humans KW - Receptors, IgG -- metabolism KW - Cloning, Molecular KW - Cells, Cultured KW - Receptors, Immunologic -- metabolism KW - Antigens, CD -- metabolism KW - Cytotoxicity Tests, Immunologic KW - Enzyme-Linked Immunosorbent Assay KW - Cell Adhesion -- immunology KW - Drosophila KW - Membrane Glycoproteins -- metabolism KW - Signal Transduction -- immunology KW - Intercellular Adhesion Molecule-1 -- genetics KW - Cytotoxicity, Immunologic -- immunology KW - Killer Cells, Natural -- metabolism KW - Cytoplasmic Granules -- metabolism KW - Intercellular Adhesion Molecule-1 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68655455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+experimental+medicine&rft.atitle=Cytolytic+granule+polarization+and+degranulation+controlled+by+different+receptors+in+resting+NK+cells.&rft.au=Bryceson%2C+Yenan+T%3BMarch%2C+Michael+E%3BBarber%2C+Domingo+F%3BLjunggren%2C+Hans-Gustaf%3BLong%2C+Eric+O&rft.aulast=Bryceson&rft.aufirst=Yenan&rft.date=2005-10-03&rft.volume=202&rft.issue=7&rft.spage=1001&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+experimental+medicine&rft.issn=00221007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-02 N1 - Date created - 2005-10-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Opin Cell Biol. 2003 Oct;15(5):547-56 [14519389] Cancer J. 2003 Jul-Aug;9(4):232-7 [12967130] J Cell Sci. 2003 Dec 1;116(Pt 23):4695-705 [14600256] Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14145-50 [14610278] J Clin Invest. 2004 Jan;113(1):49-57 [14702108] EMBO J. 2004 Jan 28;23(2):255-9 [14685277] J Exp Med. 2004 Apr 5;199(7):925-36 [15051762] Mol Cell Biol. 2004 Jun;24(12):5144-56 [15169881] Mol Immunol. 2004 Jul;41(6-7):569-75 [15219995] Blood. 2004 Aug 15;104(4):1083-93 [15113754] J Immunol. 2004 Sep 15;173(6):3653-9 [15356110] Clin Cancer Res. 2004 Sep 15;10(18 Pt 1):6248-55 [15448014] Eur J Immunol. 1983 Mar;13(3):202-8 [6339253] Eur J Immunol. 1984 Jun;14(6):518-23 [6610556] Cell. 1990 Jun 29;61(7):1303-13 [1694723] Immunol Today. 1990 Jul;11(7):237-44 [2201309] Nature. 1990 Sep 13;347(6289):189-91 [2203969] J Exp Med. 1991 May 1;173(5):1099-109 [2022921] J Exp Med. 1993 Oct 1;178(4):1397-406 [8376943] Immunity. 1995 Dec;3(6):801-9 [8777725] Immunity. 1997 Jun;6(6):655-61 [9208838] Curr Opin Cell Biol. 1997 Oct;9(5):643-50 [9330867] Curr Top Microbiol Immunol. 1998;230:63-88 [9586351] Curr Top Microbiol Immunol. 1998;230:89-99 [9586352] J Immunol. 1998 Jun 15;160(12):5781-9 [9637488] J Exp Med. 1998 Aug 3;188(3):549-59 [9687532] Immunol Rev. 1998 Jun;163:197-215 [9700512] J Immunol. 1998 Dec 1;161(11):5809-12 [9834056] J Exp Med. 1998 Dec 7;188(11):2083-90 [9841922] Nat Med. 1999 Jan;5(1):90-6 [9883845] Eur J Immunol. 1999 May;29(5):1676-83 [10359122] Mol Immunol. 2005 Feb;42(4):477-84 [15607802] Annu Rev Immunol. 2005;23:225-74 [15771571] Nat Immunol. 2005 May;6(5):515-23 [15821739] Leukemia. 2005 May;19(5):835-40 [15744340] Proc Natl Acad Sci U S A. 2005 May 3;102(18):6437-42 [15851656] Blood. 2005 Jun 1;105(11):4416-23 [15728129] Blood. 2005 Jun 15;105(12):4722-9 [15713798] Eur J Immunol. 2000 Mar;30(3):787-93 [10741393] Curr Opin Cell Biol. 2000 Oct;12(5):542-7 [10978887] Eur J Immunol. 2000 Dec;30(12):3723-31 [11169416] Nature. 2001 Feb 22;409(6823):1055-60 [11234016] J Biol Chem. 2001 May 11;276(19):16469-77 [11297532] Eur J Immunol. 2001 Oct;31(10):3121-7 [11592089] Trends Immunol. 2001 Nov;22(11):633-40 [11698225] Curr Opin Hematol. 2002 Jan;9(1):30-5 [11753075] Annu Rev Immunol. 2002;20:323-70 [11861606] Nat Rev Immunol. 2001 Oct;1(1):41-9 [11905813] Nat Rev Immunol. 2002 Oct;2(10):735-47 [12360212] J Immunol. 2003 Jan 1;170(1):294-9 [12496412] Nat Immunol. 2003 May;4(5):399-403 [12719728] J Exp Med. 2003 Aug 4;198(3):469-74 [12885870] Mol Cell Biol. 2003 Sep;23(17):6291-9 [12917349] J Immunol Methods. 2003 Oct 1;281(1-2):65-78 [14580882] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - DNA damage among thyroid cancer and multiple cancer cases, controls, and long-lived individuals AN - 21044660; 6500578 AB - Variation in the detection, signaling, and repair of DNA damage contributes to human cancer risk. To assess capacity to modulate endogenous DNA damage among radiologic technologists who had been diagnosed with breast cancer and another malignancy (breast-other, n=42), early-onset breast cancer (early-onset, age approximately equal to 35; n=38), thyroid cancer (n=68), long-lived cancer-free individuals (hyper-normals, n=20) and cancer-free controls (n=49) we quantified DNA damage (single strand breaks and abasic sites) in untreated lymphoblastoid cell lines using the alkaline comet assay. Komet(TM) software provided comet tail length, % DNA in tail (tail DNA), comet distributed moment (CDM), and Olive tail moment (OTM) summarized as the geometric mean of 100 cells. Category cut-points (median and 75th percentile) were determined from the distribution among controls. Tail length (for >=75% versus below the median, age-adjusted) was most consistently associated with the highest odds ratios in the breast-other, early-onset, and thyroid cancer groups (with risk increased 10-, 5- or 19-fold, respectively, with wide confidence intervals) and decreased risk among the hyper-normal group. For the other three comet measures, risk of breast-other was elevated approximately three-fold. Risk of early-onset breast cancer was mixed and risk of thyroid cancer ranged from null to a two-fold increase. The hyper-normal group showed decreased odds ratios for tail DNA and OTM, but not CDM. DNA damage, as estimated by all comet measures, was relatively unaffected by survival time, reproductive factors, and prior radiation treatment. We detected a continuum of endogenous DNA damage that was highest among cancer cases, less in controls, and suggestively lowest in hyper-normal individuals. Measuring this DNA damage phenotype may contribute to the identification of susceptible sub-groups. Our observations require replication in a prospective study with a large number of pre-diagnostic samples. JF - Mutation Research-Genetic Toxicology and Environmental Mutagenesis AU - Sigurdson, A J AU - Hauptmann, M AU - Alexander, B H AU - Doody, M M AU - Thomas, C B AU - Struewing, J P AU - Jones, I M AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, EPS 7092, MSC 7238, Bethesda, MD 20892-7238, USA, sigurdsa@mail.nih.gov Y1 - 2005/10/03/ PY - 2005 DA - 2005 Oct 03 SP - 173 EP - 188 PB - Elsevier B.V. VL - 586 IS - 2 SN - 1383-5718, 1383-5718 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Olea KW - Age KW - Replication KW - Tails KW - Survival KW - Mutagenesis KW - Computer programs KW - DNA damage KW - software KW - Malignancy KW - Lymphoblastoid cell lines KW - Radiation KW - thyroid cancer KW - Breast cancer KW - Comet assay KW - Signal transduction KW - N 14100:Reviews KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21044660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research-Genetic+Toxicology+and+Environmental+Mutagenesis&rft.atitle=DNA+damage+among+thyroid+cancer+and+multiple+cancer+cases%2C+controls%2C+and+long-lived+individuals&rft.au=Sigurdson%2C+A+J%3BHauptmann%2C+M%3BAlexander%2C+B+H%3BDoody%2C+M+M%3BThomas%2C+C+B%3BStruewing%2C+J+P%3BJones%2C+I+M&rft.aulast=Sigurdson&rft.aufirst=A&rft.date=2005-10-03&rft.volume=586&rft.issue=2&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Mutation+Research-Genetic+Toxicology+and+Environmental+Mutagenesis&rft.issn=13835718&rft_id=info:doi/10.1016%2Fj.mrgentox.2005.07.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-01-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Age; Tails; Replication; Survival; Mutagenesis; DNA damage; Computer programs; Malignancy; software; Radiation; Lymphoblastoid cell lines; thyroid cancer; Breast cancer; Comet assay; Signal transduction; Olea DO - http://dx.doi.org/10.1016/j.mrgentox.2005.07.001 ER - TY - CPAPER T1 - Does Treatment-Induced Recovery from Hepatitis C Result in the Same Immunological Memory as Spontaneous Recovery? T2 - 12th International Symposium on Hepatitis C Virus and Related Viruses AN - 40121190; 4001109 JF - 12th International Symposium on Hepatitis C Virus and Related Viruses AU - Weiler-Normann, Christina Y1 - 2005/10/02/ PY - 2005 DA - 2005 Oct 02 KW - Immunological memory KW - Spontaneous recovery KW - Hepatitis C KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40121190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+International+Symposium+on+Hepatitis+C+Virus+and+Related+Viruses&rft.atitle=Does+Treatment-Induced+Recovery+from+Hepatitis+C+Result+in+the+Same+Immunological+Memory+as+Spontaneous+Recovery%3F&rft.au=Weiler-Normann%2C+Christina&rft.aulast=Weiler-Normann&rft.aufirst=Christina&rft.date=2005-10-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+International+Symposium+on+Hepatitis+C+Virus+and+Related+Viruses&rft.issn=&rft_id=info:doi/ L2 - http://www.hcv2005.com/ProgramThemes.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Production of Infectious Hepatitis C Virus in Cell Culture T2 - 12th International Symposium on Hepatitis C Virus and Related Viruses AN - 40093951; 4001066 JF - 12th International Symposium on Hepatitis C Virus and Related Viruses AU - Kato, Takanobu Y1 - 2005/10/02/ PY - 2005 DA - 2005 Oct 02 KW - Viral diseases KW - Cell culture KW - Hepatitis KW - Hepatitis C virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40093951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+International+Symposium+on+Hepatitis+C+Virus+and+Related+Viruses&rft.atitle=Production+of+Infectious+Hepatitis+C+Virus+in+Cell+Culture&rft.au=Kato%2C+Takanobu&rft.aulast=Kato&rft.aufirst=Takanobu&rft.date=2005-10-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+International+Symposium+on+Hepatitis+C+Virus+and+Related+Viruses&rft.issn=&rft_id=info:doi/ L2 - http://www.hcv2005.com/ProgramThemes.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunization of Chimpanzees with Hepatitis C Virus-Like Particles Induces Partial Protection Against Hepatitis C Virus Infection T2 - 12th International Symposium on Hepatitis C Virus and Related Viruses AN - 40044806; 4001112 JF - 12th International Symposium on Hepatitis C Virus and Related Viruses AU - Elmowalid, Gamal Y1 - 2005/10/02/ PY - 2005 DA - 2005 Oct 02 KW - Virus-like particles KW - Particulates KW - Infectious diseases KW - Immunization KW - Hepatitis C KW - Hepatitis C virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40044806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+International+Symposium+on+Hepatitis+C+Virus+and+Related+Viruses&rft.atitle=Immunization+of+Chimpanzees+with+Hepatitis+C+Virus-Like+Particles+Induces+Partial+Protection+Against+Hepatitis+C+Virus+Infection&rft.au=Elmowalid%2C+Gamal&rft.aulast=Elmowalid&rft.aufirst=Gamal&rft.date=2005-10-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+International+Symposium+on+Hepatitis+C+Virus+and+Related+Viruses&rft.issn=&rft_id=info:doi/ L2 - http://www.hcv2005.com/ProgramThemes.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Only the C- Terminal Subunit of the Gbv-B P13 Protein is Required for Infectivity in Tamarins: Generation of a Recombinant Gbv-B Virus with a P7 Protein T2 - 12th International Symposium on Hepatitis C Virus and Related Viruses AN - 40044572; 4001069 JF - 12th International Symposium on Hepatitis C Virus and Related Viruses AU - Takikawa, Shingo Y1 - 2005/10/02/ PY - 2005 DA - 2005 Oct 02 KW - Recombinants KW - Infectivity KW - p7 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40044572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+International+Symposium+on+Hepatitis+C+Virus+and+Related+Viruses&rft.atitle=Only+the+C-+Terminal+Subunit+of+the+Gbv-B+P13+Protein+is+Required+for+Infectivity+in+Tamarins%3A+Generation+of+a+Recombinant+Gbv-B+Virus+with+a+P7+Protein&rft.au=Takikawa%2C+Shingo&rft.aulast=Takikawa&rft.aufirst=Shingo&rft.date=2005-10-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+International+Symposium+on+Hepatitis+C+Virus+and+Related+Viruses&rft.issn=&rft_id=info:doi/ L2 - http://www.hcv2005.com/ProgramThemes.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Sustained cadherin 23 expression in young and adult cochlea of normal and hearing-impaired mice. AN - 85395695; pmid-16005171 AB - Cadherin 23 encodes a single-pass transmembrane protein with 27 extracellular cadherin-domains and localizes to stereocilia where it functions as an inter-stereocilia link. Cadherin 23-deficient mice show congenital deafness in combination with circling behavior as a result of organizational defects in the stereocilia hair bundle; common inbred mouse strains carrying the hypomorphic Cdh23(753A) allele are highly susceptible to sensorineural hearing loss. Here, we show that an antibody (N1086) directed against the intracellular carboxyterminus reacts specifically with cadherin 23 and detects with high sensitivity the isoform devoid of the peptide encoded by exon 68 (CDH23Delta68). Cochlea, vestibule, eye, brain and testis produce the CDH23Delta68 isoform in abundance and form moieties with different molecular weight due to variations in glycosylation content. In the cochlea, CDH23Delta68 expression is highest at postnatal day 1 (P1) and P7; expression is down regulated through P14 and P21 and persists at a low steady-state level throughout adulthood (P160). Furthermore, CDH23Delta68 expression levels in young and adult cochlea are similar among normal and hearing deficient strains (C3HeB/FeJ, C57BL/6J and BUB/BnJ). Finally, by immunofluorescence using an antibody (Pb240) specific for ectodomain 14, we show that cadherin 23 localizes to stereocilia during hair bundle development in late gestation and early postnatal days. Cadherin 23-specific labeling becomes weaker as the hair bundle matures but faint labeling concentrated near the top of stereocilia is still detectable at P35. No labeling of cochlea stereocilia was observed with N1086. In conclusion, our data describe a cadherin 23-specific antibody with high affinity to the CDH23Delta68 isoform, reveal a dynamic cochlea expression and localization profile and show sustained cadherin 23 levels in adult cochlea of normal and hearing-impaired mice. JF - Hearing research AU - Rzadzinska, Agnieszka K AU - Derr, Adam AU - Kachar, Bechara AU - Noben-Trauth, Konrad AD - Section on Structural Cell Biology, Laboratory of Cellular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 114 EP - 121 VL - 208 IS - 1-2 SN - 0378-5955, 0378-5955 KW - Index Medicus KW - National Library of Medicine KW - Amino Acid Sequence KW - Animals KW - Animals, Newborn KW - Antibody Specificity KW - Base Sequence KW - Cadherins: chemistry KW - *Cadherins: genetics KW - Cadherins: immunology KW - Cadherins: metabolism KW - Cochlea: embryology KW - Cochlea: growth & development KW - Cochlea: metabolism KW - Cochlea: pathology KW - DNA, Complementary: genetics KW - Female KW - Gene Expression Regulation, Developmental KW - Glycosylation KW - *Hearing Loss, Sensorineural: genetics KW - Hearing Loss, Sensorineural: metabolism KW - Hearing Loss, Sensorineural: pathology KW - Male KW - Mice KW - Mice, Inbred C3H KW - Mice, Inbred CBA KW - Mice, Knockout KW - Mice, Mutant Strains KW - Rats KW - Rats, Sprague-Dawley KW - Tissue Distribution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85395695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hearing+research&rft.atitle=Sustained+cadherin+23+expression+in+young+and+adult+cochlea+of+normal+and+hearing-impaired+mice.&rft.au=Rzadzinska%2C+Agnieszka+K%3BDerr%2C+Adam%3BKachar%2C+Bechara%3BNoben-Trauth%2C+Konrad&rft.aulast=Rzadzinska&rft.aufirst=Agnieszka&rft.date=2005-10-01&rft.volume=208&rft.issue=1-2&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Hearing+research&rft.issn=03785955&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Role of the liver-specific transporters OATP1B1 and OATP1B3 in governing drug elimination. AN - 70182647; 16863454 AB - Members of the organic anion transporting polypeptide (OATP) family are responsible for the cellular uptake of a broad range of endogenous compounds and xenobiotics in multiple tissues. This review focuses on OATP1B1 and -1B3, which are specifically expressed in the liver and considered to be of particular importance for hepatic drug elimination and drug pharmacokinetics. Recent literature has indicated that inhibition of these transporters may result in drug-drug interactions. Furthermore, genetic polymorphisms in the genes encoding OATP1B1 and -1B3 have been described that increase or decrease transport in vitro and in vivo. Alteration of transporter function by either of these mechanisms may contribute to interindividual variability in drug disposition and response. In this review an update of this rapidly emerging field is provided. JF - Expert opinion on drug metabolism & toxicology AU - Smith, Nicola F AU - Figg, William D AU - Sparreboom, Alex AD - National Cancer Institute, Molecular Pharmacology Section, Medical Oncology Branch, Center for Cancer Research, 9000 Rockville Pike, Bethesda, MD 20892, USA. smithni@mail.nih.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 429 EP - 445 VL - 1 IS - 3 SN - 1742-5255, 1742-5255 KW - Organic Anion Transporters KW - 0 KW - Organic Anion Transporters, Sodium-Independent KW - Pharmaceutical Preparations KW - SLCO1B1 protein, human KW - SLCO1B3 protein, human KW - Solute Carrier Organic Anion Transporter Family Member 1b1 KW - Index Medicus KW - Animals KW - Drug Interactions KW - Humans KW - Pharmacogenetics KW - Organic Anion Transporters, Sodium-Independent -- metabolism KW - Organic Anion Transporters, Sodium-Independent -- genetics KW - Pharmaceutical Preparations -- metabolism KW - Organic Anion Transporters -- genetics KW - Organic Anion Transporters -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70182647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.atitle=Role+of+the+liver-specific+transporters+OATP1B1+and+OATP1B3+in+governing+drug+elimination.&rft.au=Smith%2C+Nicola+F%3BFigg%2C+William+D%3BSparreboom%2C+Alex&rft.aulast=Smith&rft.aufirst=Nicola&rft.date=2005-10-01&rft.volume=1&rft.issue=3&rft.spage=429&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.issn=17425255&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-29 N1 - Date created - 2006-07-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CONF T1 - Predictive ADME-Tox London, UK, 27 -- 28 April 2005. AN - 70182495; 16863462 AB - The Predictive ADME-Tox conference brought together scientists responsible for innovative in vitro and in silico screens to predict particular chemical liabilities. Oral bioavailability without adverse effects requires good absorption, distribution, metabolism and excretion (ADME) and minimal toxicity. Traditionally, these properties are measured late in development, when sufficient material is available for classical assays. Although these assays remain the gold standard, the conference focused on novel methods to predict liabilities early in the development pipeline, when a course change has less impact in the development timeline. Emerging themes from the meeting were i) integration - of data from a number of predictive assays into a 'profile' of a new class, and of safety scientists into discovery teams, in order to guide interpretation of the profile and identify tests to include in the hit-to-lead process; and ii) collaboration. As in silico predictive models are increasingly accepted, from reactivity and genetic toxicity to models for hERG inhibition, kinase crossreactivity and cytochrome P450 reactivity, increasing amounts of high-quality data will be needed to 'feed' the models. Such data will soon be beyond the capabilities of individual organisations to generate, and methods for pooling data are needed to advance the generation of predictive models for new toxicities. In addition, collaboration to apply novel methods such as metabonomics profiling to withdrawn drugs may permit the identification of new safety biomarkers to prevent such costly failures. JF - Expert opinion on drug metabolism & toxicology AU - Fostel, Jennifer Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 565 EP - 570 VL - 1 IS - 3 KW - Pharmaceutical Preparations KW - 0 KW - Index Medicus KW - Computer Simulation KW - Pharmacology KW - Toxicogenetics KW - Drug Design KW - Pharmaceutical Preparations -- metabolism KW - Biotransformation KW - Tissue Distribution KW - Pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70182495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.atitle=Predictive+ADME-Tox+London%2C+UK%2C+27+--+28+April+2005.&rft.au=Fostel%2C+Jennifer&rft.aulast=Fostel&rft.aufirst=Jennifer&rft.date=2005-10-01&rft.volume=1&rft.issue=3&rft.spage=565&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.issn=17425255&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-29 N1 - Date created - 2006-07-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Usefulness of salivary trans-3'-hydroxycotinine concentration and trans-3'-hydroxycotinine/cotinine ratio as biomarkers of cigarette smoke in pregnant women. AN - 69071253; 16419402 AB - Nicotine is rapidly and extensively metabolized in humans and negatively impacts the developing fetus. The concentrations of nicotine, cotinine, trans-3'-hydroxycotinine (hydroxycotinine), and norcotinine in pregnant smokers' oral fluid were evaluated to determine usefulness as biomarkers of cigarette smoking. Sixteen participants were divided into two groups: eight light smokers (LS) who smoked or =20 cigarettes/day. Oral fluid specimens (n=415) were collected throughout pregnancy and analyzed with solid-phase extraction followed by gas chromatography-mass spectrometry-electron impact selected ion monitoring. Median concentrations of nicotine, cotinine, and hydroxycotinine in oral fluid of LS ranged from 241.1 to 622.0, 80.6 to 387.5, and 14.4 to 117.7 ng/mL and for HS 146.5-1372.2, 66.0-245.8, and 38.3-184.4 ng/mL, respectively. Salivary cotinine and hydroxycotinine concentrations were significantly correlated in LS (r = 0.55, p < 0.01) and HS (r = 0.74, p < 0.01). Ratios of hydroxycotinine/cotinine in oral fluid from pregnant women averaged 0.30 +/- 0.18 (range, 0.07-1.05) for LS and 0.68 +/- 0.25 (range, 0.29-1.83) for HS. Based on these preliminary data, the best ratio to differentiate light from heavy pregnant smokers was 0.41. Salivary hydroxycotinine and cotinine concentrations are both good biomarkers of cigarette smoking. Determining the hydroxycotinine/cotinine ratio may differentiate light from heavy tobacco use and help predict increased fetal tobacco exposure. JF - Journal of analytical toxicology AU - Kim, Insook AU - Wtsadik, Abraham AU - Choo, Robin E AU - Jones, Hendrée E AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA. Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 689 EP - 695 VL - 29 IS - 7 SN - 0146-4760, 0146-4760 KW - Biomarkers KW - 0 KW - hydroxycotinine KW - 27323-64-4 KW - Cotinine KW - K5161X06LL KW - Index Medicus KW - Tobacco Use Disorder -- metabolism KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Tobacco Use Disorder -- prevention & control KW - Female KW - Pregnancy KW - Cotinine -- analysis KW - Smoking KW - Saliva -- chemistry KW - Biomarkers -- analysis KW - Cotinine -- analogs & derivatives KW - Saliva -- metabolism KW - Cotinine -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69071253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+analytical+toxicology&rft.atitle=Usefulness+of+salivary+trans-3%27-hydroxycotinine+concentration+and+trans-3%27-hydroxycotinine%2Fcotinine+ratio+as+biomarkers+of+cigarette+smoke+in+pregnant+women.&rft.au=Kim%2C+Insook%3BWtsadik%2C+Abraham%3BChoo%2C+Robin+E%3BJones%2C+Hendr%C3%A9e+E%3BHuestis%2C+Marilyn+A&rft.aulast=Kim&rft.aufirst=Insook&rft.date=2005-10-01&rft.volume=29&rft.issue=7&rft.spage=689&rft.isbn=&rft.btitle=&rft.title=Journal+of+analytical+toxicology&rft.issn=01464760&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-03 N1 - Date created - 2006-01-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mode of action: impaired fetal leydig cell function--effects on male reproductive development produced by certain phthalate esters. AN - 69070513; 16417038 AB - Certain phthalate esters (di-2-ethylhexyl; di-n-butyl and butyl benzyl) have profound effects on the developing male reproductive system when administered orally to pregnant experimental animals during a critical window of development. These esters produce a syndrome of adverse effects that are characteristic of a disturbance in androgen-mediated development and include a variety of reproductive tract malformations and effects on developmental phenotypic markers. A testicular dysgenesis syndrome has been proposed to explain the secular increases in a number of human male reproductive deficits, including decreased semen parameters, increased incidence of cryptorchidism and hypospadias (two of the most common human birth defects), and increased incidence of testicular (germ cell derived) cancer. The rodent phthalate data lend support to the hypothesis. This example illustrates a number of points in the use of the Human Relevance Framework. First, chemical agents may have more than one mode of action (MOA): for example, phthalate-induced peroxisome proliferation leading to hepatocarcinogensis, compared with the induction of developmental effects via effects on androgen signaling. Second, the case demonstrates the life-stage sensitivity of the response to these compounds. Third, because humans may be exposed to multiple phthalate esters producing adverse effects on reproductive development, these compounds may be useful in testing the utility of the Human Relevance Framework (HRF) approach for evaluating cumulative and aggregate risk. JF - Critical reviews in toxicology AU - Foster, Paul M D AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. foster2@niehs.nih.gov PY - 2005 SP - 713 EP - 719 VL - 35 IS - 8-9 SN - 1040-8444, 1040-8444 KW - Phthalic Acids KW - 0 KW - Teratogens KW - Index Medicus KW - Animals KW - Humans KW - Species Specificity KW - Male KW - Female KW - Pregnancy KW - Abnormalities, Drug-Induced -- pathology KW - Leydig Cells -- physiology KW - Genitalia, Male -- embryology KW - Genitalia, Male -- drug effects KW - Fetus -- physiology KW - Leydig Cells -- drug effects KW - Phthalic Acids -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69070513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+toxicology&rft.atitle=Mode+of+action%3A+impaired+fetal+leydig+cell+function--effects+on+male+reproductive+development+produced+by+certain+phthalate+esters.&rft.au=Foster%2C+Paul+M+D&rft.aulast=Foster&rft.aufirst=Paul+M&rft.date=2005-10-01&rft.volume=35&rft.issue=8-9&rft.spage=713&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+toxicology&rft.issn=10408444&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-08 N1 - Date created - 2006-01-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Symptomatological structure of volatile solvent-induced psychosis: is "solvent psychosis" a discernible syndrome? AN - 68853533; 16316074 AB - Solvent-induced psychosis has been clinically identified among patients suffering from dependence on volatile solvents and those in psychotic state due to chronic solvent use. To clarify the symptomatological difference between solvent-induced psychosis and schizophrenia, the principal component analysis with VARIMAX rotation was applied to the point and duration estimates of symptoms observed among the solvent group and among the schizophrenic group. There were no significant group differences in age and family history of any psychosis. The study findings are as follows: (1) It is difficult to distinguish two groups based on the prevalence rates of symptoms alone. (2) However, the principal component VARIMAX rotation analysis of the prevalence and duration observing among the solvent group revealed seven factors consisting of "amotivation", "intoxication", "emotional instability", "delusion", "hallucination", "disinhibition" and "memory". The seven factors explained 75.4% of the variance of the symptoms in this group. (3) The same analysis applied to the data from the schizophrenic group showed six factors consisting of "thought progression", "emotional instability", "amotivation (or negative symptoms)", "delusion", "hallucination" and "anxiety". These factors explained 62.9% of the variance in the data of the schizophrenic group. These results support clinical observations the "amotivational syndrome" may be a characteristic feature of patients suffering from solvent-induced psychosis. The results also suggest "solvent psychosis" is a discernible syndrome, and is distinctive from psychotic symptoms of typical schizophrenia. JF - Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence AU - Wada, Kiyoshi AU - Nakayama, Kazuhiro AU - Koishikawa, Hiraki AU - Katayama, Masafumi AU - Hirai, Shinji AU - Yabana, Tatsuo AU - Aoki, Tsutomu AU - Iwashita, Satoru AD - National Institute of Mental Health, NCNP, 4-1-1 Ogawahigashi-cho, Kodairashi, Tokyo 187-8553, Japan. Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 471 EP - 484 VL - 40 IS - 5 SN - 1341-8963, 1341-8963 KW - Solvents KW - 0 KW - Index Medicus KW - Schizophrenia -- classification KW - Humans KW - Adult KW - Male KW - Female KW - Solvents -- adverse effects KW - Psychoses, Substance-Induced -- etiology KW - Psychoses, Substance-Induced -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68853533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nihon+Arukoru+Yakubutsu+Igakkai+zasshi+%3D+Japanese+journal+of+alcohol+studies+%26+drug+dependence&rft.atitle=Symptomatological+structure+of+volatile+solvent-induced+psychosis%3A+is+%22solvent+psychosis%22+a+discernible+syndrome%3F&rft.au=Wada%2C+Kiyoshi%3BNakayama%2C+Kazuhiro%3BKoishikawa%2C+Hiraki%3BKatayama%2C+Masafumi%3BHirai%2C+Shinji%3BYabana%2C+Tatsuo%3BAoki%2C+Tsutomu%3BIwashita%2C+Satoru&rft.aulast=Wada&rft.aufirst=Kiyoshi&rft.date=2005-10-01&rft.volume=40&rft.issue=5&rft.spage=471&rft.isbn=&rft.btitle=&rft.title=Nihon+Arukoru+Yakubutsu+Igakkai+zasshi+%3D+Japanese+journal+of+alcohol+studies+%26+drug+dependence&rft.issn=13418963&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-19 N1 - Date created - 2005-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A phase II study of perifosine in androgen independent prostate cancer. AN - 68825438; 16138006 AB - Perifosine is an alkylphospholipid that has exhibited broad antineoplastic activity in preclinical studies. The primary objective of this study was to determine the clinical efficacy of this agent in the treatment of androgen-independent prostate cancer (AIPC) using PSA and clinical criteria. Nineteen patients with progressive, metastatic AIPC were treated with oral perifosine. Cycles were 28 days in length. A loading dose of 900 mg was given on day 1 of cycle 1 followed by a maintenance dose of 150 mg daily for the next 20 days. A loading dose of 600 mg was administered on the first day of subsequent cycles by the maintenance dose of 150 mg daily for the next 20 days. Pharmacokinetic measurements were made throughout the course of the study. Circulating epithelial cells were collected via leukapheresis on day 0, 3, and 28. Median patient age was 67 years and median PSA was 180 ng/mL (range: 19-904 ng/ml). Grade 1-2 fatigue and gastrointestinal toxicities were common. Pharmacokinetic studies showed an average minimum concentration at steady-state of approximately 4059 ng/ml which correlated well with previous studies. Median time to progression was four weeks. There were no radiographic responses or PSA declines of 50% or greater related to perifosine. Treatment with perifosine was complicated by fatigue and gastrointestinal toxicity. No significant clinical activity against prostate cancer was observed. This agent does not merit further study in the setting of monotherapy in this population. JF - Cancer biology & therapy AU - Posadas, Edwin M AU - Gulley, James AU - Arlen, Philip M AU - Trout, Alisa AU - Parnes, Howard L AU - Wright, John AU - Lee, Min-Jung AU - Chung, Eun Joo AU - Trepel, Jane B AU - Sparreboom, Alex AU - Chen, Clara AU - Jones, Elizabeth AU - Steinberg, Seth M AU - Daniels, Andrew AU - Figg, William D AU - Dahut, William L AD - Medical Oncology Clinical Research Unit, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 1133 EP - 1137 VL - 4 IS - 10 SN - 1538-4047, 1538-4047 KW - Androgens KW - 0 KW - Antineoplastic Agents KW - Phosphorylcholine KW - 107-73-3 KW - perifosine KW - 2GWV496552 KW - Prostate-Specific Antigen KW - EC 3.4.21.77 KW - Index Medicus KW - Leukapheresis KW - Drug Administration Schedule KW - Aged, 80 and over KW - Humans KW - Prostate-Specific Antigen -- blood KW - Treatment Outcome KW - Neoplasm Metastasis KW - Disease Progression KW - Aged KW - Middle Aged KW - Time Factors KW - Male KW - Prostatic Neoplasms -- pathology KW - Phosphorylcholine -- administration & dosage KW - Antineoplastic Agents -- administration & dosage KW - Antineoplastic Agents -- pharmacokinetics KW - Prostatic Neoplasms -- blood KW - Androgens -- physiology KW - Phosphorylcholine -- pharmacokinetics KW - Phosphorylcholine -- pharmacology KW - Prostatic Neoplasms -- drug therapy KW - Antineoplastic Agents -- pharmacology KW - Phosphorylcholine -- analogs & derivatives KW - Phosphorylcholine -- adverse effects KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68825438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+biology+%26+therapy&rft.atitle=A+phase+II+study+of+perifosine+in+androgen+independent+prostate+cancer.&rft.au=Posadas%2C+Edwin+M%3BGulley%2C+James%3BArlen%2C+Philip+M%3BTrout%2C+Alisa%3BParnes%2C+Howard+L%3BWright%2C+John%3BLee%2C+Min-Jung%3BChung%2C+Eun+Joo%3BTrepel%2C+Jane+B%3BSparreboom%2C+Alex%3BChen%2C+Clara%3BJones%2C+Elizabeth%3BSteinberg%2C+Seth+M%3BDaniels%2C+Andrew%3BFigg%2C+William+D%3BDahut%2C+William+L&rft.aulast=Posadas&rft.aufirst=Edwin&rft.date=2005-10-01&rft.volume=4&rft.issue=10&rft.spage=1133&rft.isbn=&rft.btitle=&rft.title=Cancer+biology+%26+therapy&rft.issn=15384047&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-22 N1 - Date created - 2005-11-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hodgkin lymphoma in temporal association with growth hormone replacement. AN - 68796226; 16284435 AB - The association between growth hormone (GH) replacement and malignancy has long been debated. We report a case of Hodgkin lymphoma that developed in temporal association with the initiation of GH replacement in a 57-year-old woman with panhypopituitarism secondary to a non-secretory pituitary macroadenoma. Treatment of her pituitary tumor included transphenoidal surgery, external beam radiation, Bromocriptine and Cabergaline therapy. In addition to replacement steroid, thyroid and sex hormones, she insisted on GH replacement. Approximately 2 years after GH initiation, the diagnosis of Hodgkin lymphoma was made. Although the exact contribution of GH to the development of Hodgkin disease in our patient is unclear and a causal effect cannot be concluded, the temporal association is suggestive, and warrants reporting as part of ongoing surveillance for potential complications of GH replacement. JF - Endocrine journal AU - Freedman, Renee J AU - Malkovska, Vera AU - LeRoith, Derek AU - Collins, Michael T AD - Developmental Endocrinology Branch, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA. Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 571 EP - 575 VL - 52 IS - 5 SN - 0918-8959, 0918-8959 KW - Human Growth Hormone KW - 12629-01-5 KW - Index Medicus KW - Humans KW - Adult KW - Middle Aged KW - Female KW - Adenoma -- therapy KW - Pituitary Neoplasms -- therapy KW - Human Growth Hormone -- therapeutic use KW - Hodgkin Disease -- chemically induced KW - Human Growth Hormone -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68796226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrine+journal&rft.atitle=Hodgkin+lymphoma+in+temporal+association+with+growth+hormone+replacement.&rft.au=Freedman%2C+Renee+J%3BMalkovska%2C+Vera%3BLeRoith%2C+Derek%3BCollins%2C+Michael+T&rft.aulast=Freedman&rft.aufirst=Renee&rft.date=2005-10-01&rft.volume=52&rft.issue=5&rft.spage=571&rft.isbn=&rft.btitle=&rft.title=Endocrine+journal&rft.issn=09188959&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-26 N1 - Date created - 2005-11-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification and treatment of patients with nicotine problems in routine clinical psychiatry practice. AN - 68747058; 16257881 AB - The aim of this study is to assess the rates of nicotine problems diagnosed by psychiatrists, the characteristics of psychiatric patients who smoke, and the services provided to them in routine psychiatric practice. Data were obtained by asking psychiatrists participating in the American Psychiatric Institute for Psychiatric Research and Education's Practice Research Network to complete a self-administered questionnaire to provide detailed sociodemographic, clinical, and health plan information on three of their patients seen during routine clinical practice. A total of 615 psychiatrists provided information on 1,843 patients, of which 280 (16.6%) were reported to have a current nicotine problem. Of these, 9.1% were reported to receive treatment for nicotine dependence. Patients with nicotine problems were significantly more likely to be males, divorced or separated, disabled, and uninsured, and have fewer years of education. They also had significantly more co-morbid psychiatric disorders, particularly schizophrenia or alcohol/substance use disorders; a lower Global Assessment Functioning score; and poorer treatment compliance than their counterparts. The results suggest a very low rate of identification and treatment of nicotine problems among patients treated by psychiatrists, even though psychiatric patients who smoke seem to have more clinical and psychosocial stressors and more severe psychiatric problems than those who do not smoke. Programs should be developed to raise the awareness and ability of psychiatrists to diagnose and treat patients with nicotine problems, with a particular emphasis on the increased medical and psychosocial needs of psychiatric patients who smoke. JF - The American journal on addictions AU - Montoya, Ivan D AU - Herbeck, Diane M AU - Svikis, Dace S AU - Pincus, Harold Alan AD - National Institute on Drug Abuse, Division of Pharmacotherapies and Medical Consequences of Drug Abuse, 6001 Executive Blvd., Bethesda, MD 20892-9551, USA. imontoya@mail.nih.gov PY - 2005 SP - 441 EP - 454 VL - 14 IS - 5 SN - 1055-0496, 1055-0496 KW - Index Medicus KW - United States KW - Humans KW - Adult KW - Diagnosis, Dual (Psychiatry) KW - Aged KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Mental Disorders -- diagnosis KW - Mental Disorders -- therapy KW - Tobacco Use Disorder -- therapy KW - Mental Disorders -- psychology KW - Tobacco Use Disorder -- diagnosis KW - Psychiatry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68747058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=Identification+and+treatment+of+patients+with+nicotine+problems+in+routine+clinical+psychiatry+practice.&rft.au=Montoya%2C+Ivan+D%3BHerbeck%2C+Diane+M%3BSvikis%2C+Dace+S%3BPincus%2C+Harold+Alan&rft.aulast=Montoya&rft.aufirst=Ivan&rft.date=2005-10-01&rft.volume=14&rft.issue=5&rft.spage=441&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-30 N1 - Date created - 2005-10-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Psychiatry. 1996 Oct;153(10):1247-8 [8831429] Am J Psychiatry. 1996 Oct;153(10 Suppl):1-31 [8831466] Psychiatr Serv. 1995 May;46(5):435-6 [7627666] Prev Med. 1992 Mar;21(2):262-9 [1579560] Psychiatr Serv. 1997 Jan;48(1):100-2 [9117487] Schizophr Bull. 1997;23(2):247-54 [9165635] J Addict Dis. 1998;17(1):47-54 [9549602] Am J Psychiatry. 1998 Jul;155(7):974-6 [9659869] Subst Use Misuse. 1998 Aug;33(10):2021-47 [9744841] Am J Psychiatry. 1999 Mar;156(3):451-7 [10080563] Arch Gen Psychiatry. 1999 May;56(5):441-9 [10232299] J Subst Abuse Treat. 1999 Jun;16(4):315-20 [10349604] Med Care. 1999 Jan;37(1):104-11 [10413398] Ann Clin Psychiatry. 1999 Sep;11(3):129-36 [10482122] Aust N Z J Psychiatry. 1999 Dec;33(6):869-73 [10619214] J Clin Psychiatry. 2000 Sep;61(9):698-705; quiz 706 [11030495] JAMA. 2000 Nov 22-29;284(20):2606-10 [11086367] Am J Public Health. 2000 Dec;90(12):1898-904 [11111263] Nicotine Tob Res. 2001 Aug;3(3):225-34 [11506766] Arch Gen Psychiatry. 2001 Sep;58(9):810-6 [11545662] Prog Neuropsychopharmacol Biol Psychiatry. 2002 Apr;26(3):529-37 [11999904] Addiction. 2002 Jul;97(7):861-9 [12133125] Psychiatr Serv. 2002 Sep;53(9):1166-70 [12221317] J Clin Oncol. 2003 Jan 15;21(2):355-65 [12525530] Arch Gen Psychiatry. 1986 Mar;43(3):289-94 [3954551] Am J Psychiatry. 1986 Aug;143(8):993-7 [3487983] Psychiatr J Univ Ott. 1988 Mar;13(1):25-7 [3283798] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevalence, correlates, and comorbidity of bipolar I disorder and axis I and II disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 68746613; 16259532 AB - To present nationally representative data on 12-month and lifetime prevalence, correlates, and comorbidity of bipolar I disorder. The data were derived from the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (N = 43,093). Prevalences and associations of bipolar I disorder with sociodemographic correlates and Axis I and II disorders were determined. Prevalences of 12-month and lifetime DSM-IV bipolar I disorder were 2.0% (95% CI = 1.82 to 2.18) and 3.3% (95% CI = 2.76 to 3.84), respectively, and no sex differences were observed. The odds of bipolar I disorder were significantly greater among Native Americans, younger adults, and respondents who were widowed/separated/divorced and of lower socioeconomic status and significantly lower among Asians and Hispanics (p < .05). Men were significantly (p < .05) more likely to have unipolar mania and earlier onset and longer duration of manic episodes, while women were more likely to have mixed and major depressive episodes and to be treated for manic, mixed, and major depressive episodes. Bipolar I disorder was found to be highly and significantly related (p < .05) to substance use, anxiety, and personality disorders, but not to alcohol abuse. Bipolar I disorder is more prevalent in the U.S. population than previously estimated, highlighting the underestimation of the economic costs associated with this illness. Associations between bipolar I disorder and Axis I and II disorders were all significant, underscoring the need for systematic assessment of comorbidity among bipolar I patients. JF - The Journal of clinical psychiatry AU - Grant, Bridget F AU - Stinson, Frederick S AU - Hasin, Deborah S AU - Dawson, Deborah A AU - Chou, S Patricia AU - Ruan, W June AU - Huang, Boji AD - Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-9304, USA. bgrant@willco.niaaa.nih.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 1205 EP - 1215 VL - 66 IS - 10 SN - 0160-6689, 0160-6689 KW - Index Medicus KW - Age of Onset KW - Humans KW - Aged KW - Child KW - Comorbidity KW - Age Distribution KW - Health Care Costs KW - Adult KW - Middle Aged KW - Psychiatric Status Rating Scales -- statistics & numerical data KW - Adolescent KW - United States -- epidemiology KW - Sex Distribution KW - Male KW - Diagnostic and Statistical Manual of Mental Disorders KW - Female KW - Prevalence KW - Alcohol-Related Disorders -- epidemiology KW - Mental Disorders -- diagnosis KW - Bipolar Disorder -- epidemiology KW - Mental Disorders -- epidemiology KW - Health Surveys KW - Bipolar Disorder -- classification KW - Mental Disorders -- economics KW - Bipolar Disorder -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68746613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Prevalence%2C+correlates%2C+and+comorbidity+of+bipolar+I+disorder+and+axis+I+and+II+disorders%3A+results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Grant%2C+Bridget+F%3BStinson%2C+Frederick+S%3BHasin%2C+Deborah+S%3BDawson%2C+Deborah+A%3BChou%2C+S+Patricia%3BRuan%2C+W+June%3BHuang%2C+Boji&rft.aulast=Grant&rft.aufirst=Bridget&rft.date=2005-10-01&rft.volume=66&rft.issue=10&rft.spage=1205&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-09 N1 - Date created - 2005-11-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alkaloids from amphibian skin: a tabulation of over eight-hundred compounds. AN - 68740940; 16252926 AB - A diverse array of biologically active, lipid-soluble alkaloids have been discovered in amphibian skin. Such alkaloids include the following: the steroidal samandarines from salamanders, the batrachotoxins, histrionicotoxins, gephyrotoxins, and epibatidine from neotropical poison frogs (Dendrobatidae), the pumiliotoxins, allopumiliotoxins, homopumiliotoxins, and decahydroquinolines from certain genera of anurans from four families (Dendrobatidae, Mantellidae, Bufonidae, and Myobatrachidae), a variety of izidines (pyrrolizidines, indolizidines, quinolizidines, lehmizidines), pyrrolidines, piperidines, various tricyclics (related in structures to the coccinellines), and spiropyrrolizidines from the first three of these four families, the pseudophrynamines from one genus of Australian frogs, and a variety of unclassified alkaloids as yet of undetermined structure. With the exception of the samandarines and the pseudophrynamines, all alkaloids appear to be derived from dietary sources. Although only a few of the over 800 amphibian skin alkaloids have been detected in arthropods, putative arthropod sources for the batrachotoxins and coccinelline-like tricyclics (beetles), the pumiliotoxins (ants, mites), the decahydroquinolines, izidines, pyrrolidines, and piperidines (ants), and the spiropyrrolizidines (millipedes) have been discovered. Ants are likely sources for histrionicotoxins, lehmizidines, and tricyclic gephyrotoxins. Epibatidines represent an important alkaloid class without a putative dietary source. The structures for many of these alkaloids have been rigorously established, while the structures of others represent tentative proposals, based only on mass spectral and FTIR spectral data, along with analogies to structures of well-defined alkaloids. JF - Journal of natural products AU - Daly, John W AU - Spande, Thomas F AU - Garraffo, H Martin AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-0820, USA. jdaly@nih.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 1556 EP - 1575 VL - 68 IS - 10 SN - 0163-3864, 0163-3864 KW - Alkaloids KW - 0 KW - Amphibian Venoms KW - Index Medicus KW - Molecular Structure KW - Animals KW - Amphibians -- physiology KW - Skin -- chemistry KW - Amphibian Venoms -- isolation & purification KW - Amphibian Venoms -- chemistry KW - Alkaloids -- chemistry KW - Alkaloids -- pharmacology KW - Alkaloids -- isolation & purification KW - Amphibian Venoms -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68740940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+natural+products&rft.atitle=Alkaloids+from+amphibian+skin%3A+a+tabulation+of+over+eight-hundred+compounds.&rft.au=Daly%2C+John+W%3BSpande%2C+Thomas+F%3BGarraffo%2C+H+Martin&rft.aulast=Daly&rft.aufirst=John&rft.date=2005-10-01&rft.volume=68&rft.issue=10&rft.spage=1556&rft.isbn=&rft.btitle=&rft.title=Journal+of+natural+products&rft.issn=01633864&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-30 N1 - Date created - 2005-10-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Integration of pharmacotherapy for opioid addiction into HIV primary care for HIV/hepatitis C virus-co-infected patients. AN - 68734149; 16251822 AB - Pharmacotherapy for substance abuse is a rapidly evolving field comprising both old and new effective treatments for substance use. Opiate agonist therapy has been shown to diminish and often eliminate opiate use. This behavior change has resulted in the reduced transmission of many infections, including HIV, hepatitis C virus (HCV), and an enhanced quality of life. For the past 35 years, the provision of opioid agonist therapy has been limited to opioid treatment programmes. Opioid treatment programmes treat approximately 200,000 of the estimated million opiate-addicted individuals in the United States. With the need to increase the number of treatment opportunities available for opioid-dependent patients, Congress passed the Drug Addiction Treatment Act of 2000, which allows for the treatment of opioid dependence using buprenorphine by a properly licensed physician, including HIV primary care physicians. The integration of buprenorphine treatment for opioid addiction into HIV primary care thus provides a new treatment paradigm to address substance abuse in patients with HIV and HCV infections. JF - AIDS (London, England) AU - Kresina, Thomas F AU - Eldred, Lois AU - Bruce, R Douglas AU - Francis, Henry AD - Center on AIDS and other Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA. tk13v@nih.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - S221 EP - S226 VL - 19 Suppl 3 SN - 0269-9370, 0269-9370 KW - Narcotic Antagonists KW - 0 KW - Buprenorphine KW - 40D3SCR4GZ KW - Index Medicus KW - AIDS/HIV KW - United States KW - Buprenorphine -- therapeutic use KW - Narcotic Antagonists -- therapeutic use KW - Humans KW - Substance Abuse Treatment Centers -- organization & administration KW - HIV Infections -- complications KW - Opioid-Related Disorders -- complications KW - Hepatitis C -- complications KW - Opioid-Related Disorders -- rehabilitation KW - Primary Health Care -- organization & administration KW - Delivery of Health Care, Integrated UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68734149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+%28London%2C+England%29&rft.atitle=Integration+of+pharmacotherapy+for+opioid+addiction+into+HIV+primary+care+for+HIV%2Fhepatitis+C+virus-co-infected+patients.&rft.au=Kresina%2C+Thomas+F%3BEldred%2C+Lois%3BBruce%2C+R+Douglas%3BFrancis%2C+Henry&rft.aulast=Kresina&rft.aufirst=Thomas&rft.date=2005-10-01&rft.volume=19+Suppl+3&rft.issue=&rft.spage=S221&rft.isbn=&rft.btitle=&rft.title=AIDS+%28London%2C+England%29&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-29 N1 - Date created - 2005-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - HIV/hepatitis C virus co-infection: its human face. AN - 68733814; 16251804 JF - AIDS (London, England) AU - Cargill, Victoria A AD - Office of AIDS Research, National Institutes of Health, DHHS, Bethesda, MD, USA. Y1 - 2005/10// PY - 2005 DA - October 2005 SP - S1 EP - S2 VL - 19 Suppl 3 SN - 0269-9370, 0269-9370 KW - Antiviral Agents KW - 0 KW - Index Medicus KW - AIDS/HIV KW - Antiviral Agents -- therapeutic use KW - Humans KW - Antiviral Agents -- adverse effects KW - Hepatitis C -- drug therapy KW - HIV Infections -- complications KW - Hepatitis C -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68733814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+%28London%2C+England%29&rft.atitle=HIV%2Fhepatitis+C+virus+co-infection%3A+its+human+face.&rft.au=Cargill%2C+Victoria+A&rft.aulast=Cargill&rft.aufirst=Victoria&rft.date=2005-10-01&rft.volume=19+Suppl+3&rft.issue=&rft.spage=S1&rft.isbn=&rft.btitle=&rft.title=AIDS+%28London%2C+England%29&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-29 N1 - Date created - 2005-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Integrating care for patients with infectious, psychiatric, and substance use disorders: concepts and approaches. AN - 68732727; 16251823 AB - Patients with chronic viral infections such as HIV/AIDS or hepatitis C often have multiple co-existing problems such as psychiatric and addictive disorders, as well as social problems such as lack of housing, transportation and income that present challenging obstacles to successful management. Because services for these different problems are usually provided by different disciplines in varying locations, fragmentation of care can lead to treatment dropouts, lack of adherence, and poor outcomes. Integration strategies, ranging from simple efforts to improve communication and coordinate care to fully integrated multidisciplinary teams have been used to improve disease management. Although evidence for effectiveness is comprised primarily of observational studies of demonstration programmes, integration may be desirable on a pragmatic basis alone. Quality improvement strategies are attractive vehicles for implementing care integration and measuring its impact. Careful assessment of the problem to be solved and the development of targeted strategies will maximize chances of a successful outcome. JF - AIDS (London, England) AU - Willenbring, Mark L AD - National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892-9304, USA. mlw@niaaa.nih.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - S227 EP - S237 VL - 19 Suppl 3 SN - 0269-9370, 0269-9370 KW - Index Medicus KW - AIDS/HIV KW - Substance-Related Disorders -- therapy KW - Humans KW - Disease Management KW - Diagnosis, Dual (Psychiatry) KW - Substance-Related Disorders -- complications KW - Comorbidity KW - Hepatitis C -- therapy KW - Mental Disorders -- therapy KW - Patient Care Team KW - HIV Infections -- complications KW - Hepatitis C -- complications KW - HIV Infections -- therapy KW - Mental Disorders -- complications KW - Delivery of Health Care, Integrated UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68732727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+%28London%2C+England%29&rft.atitle=Integrating+care+for+patients+with+infectious%2C+psychiatric%2C+and+substance+use+disorders%3A+concepts+and+approaches.&rft.au=Willenbring%2C+Mark+L&rft.aulast=Willenbring&rft.aufirst=Mark&rft.date=2005-10-01&rft.volume=19+Suppl+3&rft.issue=&rft.spage=S227&rft.isbn=&rft.btitle=&rft.title=AIDS+%28London%2C+England%29&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-29 N1 - Date created - 2005-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Framework for environmental exposure research: the disease-first approach. AN - 68729464; 16249520 JF - Molecular interventions AU - Wilson, Samuel H AU - Suk, William A AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. wilson5@niehs.nih.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 262 EP - 267 VL - 5 IS - 5 SN - 1534-0384, 1534-0384 KW - Index Medicus KW - Information Systems KW - Environmental Health KW - Humans KW - Research Design KW - Risk Assessment KW - Population Surveillance KW - Health Status KW - Disease Susceptibility -- etiology KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68729464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+interventions&rft.atitle=Framework+for+environmental+exposure+research%3A+the+disease-first+approach.&rft.au=Wilson%2C+Samuel+H%3BSuk%2C+William+A&rft.aulast=Wilson&rft.aufirst=Samuel&rft.date=2005-10-01&rft.volume=5&rft.issue=5&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=Molecular+interventions&rft.issn=15340384&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-24 N1 - Date created - 2005-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alpha-particle radioimmunotherapy of disseminated peritoneal disease using a (212)Pb-labeled radioimmunoconjugate targeting HER2. AN - 68729142; 16248771 AB - These studies demonstrate the feasibility of targeted therapy for the treatment of disseminated peritoneal disease using (212)Pb-labeled Herceptin as an in vivo generator of (212)Bi. In vitro studies compare the potential of the bismuth radioisotopes, (213)Bi and (212)Bi, to that of (212)Pb. Overall, (212)Pb results in a higher therapeutic index than either bismuth radioisotope, requiring lower radioactivity (microCi) for effective cytotoxic response. A pilot radioimmunotherapy (RIT) experiment treating mice bearing 5 d LS-174T intraperitoneally (i.p.) xenografts determined a maximum tolerated dose (MTD) of 20-40 microCi with i.p. administration. A specific dose response was observed and 10 microCi was selected as the effective operating dose for future experiments. Median survival of tumor-bearing mice receiving 10 microCi increased from 19 to 56 days (p = 0.008). The efficacy of (212)Pb-Herceptin was also assessed in a human pancreatic carcinoma xenograft (Shaw; i.p.) animal model previously reported as unresponsive to 213Bi-Herceptin (p = 0.002). Multiple dosing of (212)Pb-Herceptin was evaluated in both animal models. The median survival of mice bearing 3 d LS-174T i.p. xenografts increased to 110 days, with up to 3 doses of (212)Pb-Herceptin given at approximately monthly intervals; however, there was no evidence of a correlation with the second and third doses (p = 0.98). No improvement in median survival was noted with a similar regimen in the Shaw xenograft model. JF - Cancer biotherapy & radiopharmaceuticals AU - Milenic, Diane E AU - Garmestani, Kayhan AU - Brady, Erik D AU - Albert, Paul S AU - Ma, Dangshe AU - Abdulla, Alia AU - Brechbiel, Martin W AD - Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, MSC-1088, Building 10, Bethesda, MD 20892, USA. dm71q@nih.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 557 EP - 568 VL - 20 IS - 5 SN - 1084-9785, 1084-9785 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Immunoconjugates KW - Lead Radioisotopes KW - Receptor, ErbB-2 KW - EC 2.7.10.1 KW - Trastuzumab KW - P188ANX8CK KW - Index Medicus KW - Animals KW - Genes, erbB-2 KW - Humans KW - Cell Line, Tumor KW - Mice KW - Antibodies, Monoclonal -- chemistry KW - Radioimmunoassay KW - Neoplasm Transplantation KW - Immunoconjugates -- chemistry KW - Alpha Particles KW - Flow Cytometry KW - Maximum Tolerated Dose KW - Time Factors KW - Receptor, ErbB-2 -- metabolism KW - Receptor, ErbB-2 -- immunology KW - Peritoneal Diseases -- therapy KW - Radioimmunotherapy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68729142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+biotherapy+%26+radiopharmaceuticals&rft.atitle=Alpha-particle+radioimmunotherapy+of+disseminated+peritoneal+disease+using+a+%28212%29Pb-labeled+radioimmunoconjugate+targeting+HER2.&rft.au=Milenic%2C+Diane+E%3BGarmestani%2C+Kayhan%3BBrady%2C+Erik+D%3BAlbert%2C+Paul+S%3BMa%2C+Dangshe%3BAbdulla%2C+Alia%3BBrechbiel%2C+Martin+W&rft.aulast=Milenic&rft.aufirst=Diane&rft.date=2005-10-01&rft.volume=20&rft.issue=5&rft.spage=557&rft.isbn=&rft.btitle=&rft.title=Cancer+biotherapy+%26+radiopharmaceuticals&rft.issn=10849785&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-27 N1 - Date created - 2005-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drosophila ATM and Mre11 are essential for the G2/M checkpoint induced by low-dose irradiation. AN - 68728942; 16020777 AB - Others have suggested recently that the conserved ATM checkpoint kinase is minimally involved in controlling the G(2)/M checkpoint in Drosophila that serves to prevent mitotic entry in the presence of DNA damage. Our data indicate that both ATM and its regulator Mre11 are important for the checkpoint and that their roles become essential when animals are challenged with a low dose of X rays or when they have compromised checkpoint function of the ATM-related ATR kinase. JF - Genetics AU - Bi, Xiaolin AU - Gong, Min AU - Srikanta, Deepa AU - Rong, Yikang S AD - Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 845 EP - 847 VL - 171 IS - 2 SN - 0016-6731, 0016-6731 KW - Cell Cycle Proteins KW - 0 KW - Drosophila Proteins KW - Protein-Serine-Threonine Kinases KW - EC 2.7.11.1 KW - meiotic 41 protein, Drosophila KW - Endodeoxyribonucleases KW - EC 3.1.- KW - Mre11 protein, Drosophila KW - Index Medicus KW - Animals KW - Cell Cycle Proteins -- genetics KW - Models, Genetic KW - Protein-Serine-Threonine Kinases -- genetics KW - Dose-Response Relationship, Radiation KW - Mutagenesis KW - Mitosis -- genetics KW - Genes, cdc KW - Mitosis -- radiation effects KW - Endodeoxyribonucleases -- genetics KW - Drosophila Proteins -- genetics KW - Drosophila -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68728942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genetics&rft.atitle=Drosophila+ATM+and+Mre11+are+essential+for+the+G2%2FM+checkpoint+induced+by+low-dose+irradiation.&rft.au=Bi%2C+Xiaolin%3BGong%2C+Min%3BSrikanta%2C+Deepa%3BRong%2C+Yikang+S&rft.aulast=Bi&rft.aufirst=Xiaolin&rft.date=2005-10-01&rft.volume=171&rft.issue=2&rft.spage=845&rft.isbn=&rft.btitle=&rft.title=Genetics&rft.issn=00166731&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-27 N1 - Date created - 2005-10-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Radiat Biol. 1996 May;69(5):527-37 [8648240] Curr Biol. 2004 Aug 10;14(15):1354-9 [15296752] Genes Dev. 2000 Mar 15;14(6):666-78 [10733527] Mol Cell Biol. 2001 Aug;21(15):5214-22 [11438675] Genes Dev. 2001 Sep 1;15(17):2177-96 [11544175] Mol Cell Biol. 2002 Feb;22(4):1049-59 [11809797] Nat Cell Biol. 2002 Dec;4(12):993-7 [12447390] Mol Cell. 2003 Jan;11(1):203-13 [12535533] Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4696-701 [12672954] Science. 2003 Jun 6;300(5625):1542-8 [12791985] Genetics. 2003 Jun;164(2):589-601 [12807779] Mol Cell Biol. 2004 Nov;24(22):10016-25 [15509802] Cell. 1995 Sep 8;82(5):815-21 [7671309] Mol Cell. 2003 Dec;12(6):1511-23 [14690604] Genes Dev. 2004 Aug 1;18(15):1850-61 [15256487] Curr Biol. 2004 Aug 10;14(15):1341-7 [15296750] Curr Biol. 2004 Aug 10;14(15):1348-53 [15296751] Cell. 1998 Jun 26;93(7):1183-93 [9657151] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anticholinesterase and pharmacokinetic profile of phenserine in healthy elderly human subjects. AN - 68725880; 16248851 AB - To evaluate the safety, maximum tolerated dose (MTD), pharmacokinetics (PK), and pharmacodynamics (PD) of the acetyl-selective anticholinesterase, phenserine tartrate, in healthy elderly subjects. 32 healthy elderly volunteers received single oral doses of phenserine tartrate (5-20 mg). Physical and vital signs were monitored over the ensuing 24 hours. Analyses were performed on plasma samples to determine PK, and PD were assessed using an erythrocyte acetylcholinesterase (AChE) inhibition assay. No serious adverse events (AEs) occurred; the most common were headache and vomiting. The MTD of phenserine tartrate was 10 mg. The Cmax and AUC(0-24) of phenserine increased with dose, but neither were dose-proportional. Subjects receiving 10 mg of phenserine tartrate had a Cmax of 1.95 ng/mL at 1.5 hours, and the mean peak inhibition (Imax) of AChE was 26% (range: 18-34%) at 1.75 hours (tImax) following dosing. The half-life of AChE inhibition (tI1/2) was 11 hours. Evaluation of PK/PD relationships suggested a linear correlation between plasma phenserine concentration and AChE inhibition in the blood. Phenserine tartrate was safe and well tolerated when administered as a single oral dose of either 5 mg or 10 mg. An increase in the severity and frequency of AEs occurred at the 20 mg dose level. JF - Current Alzheimer research AU - Greig, Nigel H AU - Ruckle, Jon AU - Comer, Patrick AU - Brownell, Lidia AU - Holloway, Harold W AU - Flanagan, Douglas R AU - Canfield, Craig J AU - Burford, Robert G AD - Drug Design & Development Section, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 USA. Greign@grc.nia.nih.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 483 EP - 492 VL - 2 IS - 4 SN - 1567-2050, 1567-2050 KW - Cholinesterase Inhibitors KW - 0 KW - phenserine KW - Physostigmine KW - 9U1VM840SP KW - Acetylcholinesterase KW - EC 3.1.1.7 KW - Index Medicus KW - Erythrocytes -- drug effects KW - Erythrocytes -- enzymology KW - Area Under Curve KW - Humans KW - Aged KW - Middle Aged KW - Maximum Tolerated Dose KW - Male KW - Female KW - Acetylcholinesterase -- drug effects KW - Cholinesterase Inhibitors -- adverse effects KW - Physostigmine -- analogs & derivatives KW - Cholinesterase Inhibitors -- pharmacokinetics KW - Physostigmine -- adverse effects KW - Physostigmine -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68725880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Alzheimer+research&rft.atitle=Anticholinesterase+and+pharmacokinetic+profile+of+phenserine+in+healthy+elderly+human+subjects.&rft.au=Greig%2C+Nigel+H%3BRuckle%2C+Jon%3BComer%2C+Patrick%3BBrownell%2C+Lidia%3BHolloway%2C+Harold+W%3BFlanagan%2C+Douglas+R%3BCanfield%2C+Craig+J%3BBurford%2C+Robert+G&rft.aulast=Greig&rft.aufirst=Nigel&rft.date=2005-10-01&rft.volume=2&rft.issue=4&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Current+Alzheimer+research&rft.issn=15672050&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-30 N1 - Date created - 2005-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The impact of reward, punishment, and frustration on attention in pediatric bipolar disorder. AN - 68709106; 15953589 AB - Theories in affective neuroscience suggest that mood disorders involve perturbations in attention-emotion interactions. We tested the hypothesis that frustration adversely impacts attention and behavior in children with bipolar disorder (BPD). Thirty-five children with BPD and 26 normal control subjects completed: 1) a Posner attention task with feedback but no contingencies; 2) an affective Posner with contingencies; and 3) an affective Posner that used rigged feedback to induce frustration. Reaction time (RT) and event-related potential (ERP) data were collected. At baseline (task 1), there were no between-group differences in behavior or ERPs. Children with BPD exhibited reduced parietal P3 amplitude on task 3 only. On trials occurring after negative feedback, control subjects showed decreased RT when contingencies were introduced (task 2), whereas BPD subjects did not. The introduction of contingencies was associated with impaired performance of children with BPD, suggesting deficits in their ability to adapt to changing contingencies. In addition, frustration was associated with disrupted attention allocation in children with BPD. We hypothesize that children with BPD inappropriately deployed attention to their internal frustration rather than to the task, causing impaired performance. JF - Biological psychiatry AU - Rich, Brendan A AU - Schmajuk, Mariana AU - Perez-Edgar, Koraly E AU - Pine, Daniel S AU - Fox, Nathan A AU - Leibenluft, Ellen AD - Pediatrics and Developmental Neuropsychiatry Branch, Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1255, USA. brendanrich@mail.nih.gov Y1 - 2005/10/01/ PY - 2005 DA - 2005 Oct 01 SP - 532 EP - 539 VL - 58 IS - 7 SN - 0006-3223, 0006-3223 KW - Antimanic Agents KW - 0 KW - Index Medicus KW - Reproducibility of Results KW - Affect -- physiology KW - Humans KW - Antimanic Agents -- adverse effects KW - Electroencephalography KW - Evoked Potentials -- physiology KW - Child KW - Reaction Time -- physiology KW - Psychomotor Performance -- physiology KW - Psychiatric Status Rating Scales KW - Emotions -- physiology KW - Antimanic Agents -- therapeutic use KW - Adolescent KW - Female KW - Male KW - Reward KW - Punishment KW - Frustration KW - Bipolar Disorder -- drug therapy KW - Bipolar Disorder -- psychology KW - Attention -- physiology KW - Bipolar Disorder -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68709106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=The+impact+of+reward%2C+punishment%2C+and+frustration+on+attention+in+pediatric+bipolar+disorder.&rft.au=Rich%2C+Brendan+A%3BSchmajuk%2C+Mariana%3BPerez-Edgar%2C+Koraly+E%3BPine%2C+Daniel+S%3BFox%2C+Nathan+A%3BLeibenluft%2C+Ellen&rft.aulast=Rich&rft.aufirst=Brendan&rft.date=2005-10-01&rft.volume=58&rft.issue=7&rft.spage=532&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-30 N1 - Date created - 2005-10-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Complementary and alternative medicine patients are talking about: black cohosh. AN - 68707766; 16235591 JF - Clinical journal of oncology nursing AU - Lee, Colleen O AD - Office of Cancer Complementary and Alternative Medicine at the National Cancer Institute in Bethesda, MD, USA. leeco@mail.nih.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 628 EP - 629 VL - 9 IS - 5 SN - 1092-1095, 1092-1095 KW - Nursing KW - United States KW - Patient Education as Topic KW - Evidence-Based Medicine KW - Drug Interactions KW - United States Food and Drug Administration KW - Menstruation Disturbances -- drug therapy KW - Drug and Narcotic Control KW - Menopause -- drug effects KW - Humans KW - Clinical Trials as Topic KW - Patient Selection KW - Female KW - Phytotherapy -- methods KW - Cimicifuga KW - Phytotherapy -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68707766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+journal+of+oncology+nursing&rft.atitle=Complementary+and+alternative+medicine+patients+are+talking+about%3A+black+cohosh.&rft.au=Lee%2C+Colleen+O&rft.aulast=Lee&rft.aufirst=Colleen&rft.date=2005-10-01&rft.volume=9&rft.issue=5&rft.spage=628&rft.isbn=&rft.btitle=&rft.title=Clinical+journal+of+oncology+nursing&rft.issn=10921095&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-15 N1 - Date created - 2005-10-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - WMC-79, a potent agent against colon cancers, induces apoptosis through a p53-dependent pathway. AN - 68696927; 16227412 AB - WMC-79 is a synthetic agent with potent activity against colon and hematopoietic tumors. In vitro, the agent is most potent against colon cancer cells that carry the wild-type p53 tumor suppressor gene (HCT-116 and RKO cells: GI50<1 nmol/L, LC50 approximately 40 nmol/L). Growth arrest of HCT-116 and RKO cells occurs at the G1 and G2-M check points at sublethal concentrations (10 nmol/L) but the entire cell population was killed at 100 nmol/L. WMC-79 is localized to the nucleus where it binds to DNA. We hypothesized that WMC-79 binding to DNA is recognized as an unrepairable damage in the tumor cells, which results in p53 activation. This triggers transcriptional up-regulation of p53-dependent genes involved in replication, cell cycle progression, growth arrest, and apoptosis as evidenced by DNA microarrays. The change in the transcriptional profile of HCT-116 cells is followed by a change in the levels of cell cycle regulatory proteins and apoptosis. The recruitment of the p53-dependent apoptosis pathway was suggested by the up-regulation of p53, p21, Bax, DR-4, DR-5, and p53 phosphorylated on Ser15; down-regulation of Bcl-2; and activation of caspase-8, -9, -7, and -3 in cells treated with 100 nmol/L WMC-79. Apoptosis was also evident from the flow cytometric studies of drug-treated HCT-116 cells as well as from the appearance of nuclear fragmentation. However, whereas this pathway is important in wild-type p53 colon tumors, other pathways are also in operation because colon cancer cell lines in which the p53 gene is mutated are also affected by higher concentrations of WMC-79. JF - Molecular cancer therapeutics AU - Kosakowska-Cholody, Teresa AU - Cholody, W Marek AU - Monks, Anne AU - Woynarowska, Barbara A AU - Michejda, Christopher J AD - Molecular Aspects of Drug Design, Structural Biophysics Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA. Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 1617 EP - 1627 VL - 4 IS - 10 SN - 1535-7163, 1535-7163 KW - Heterocyclic Compounds, 4 or More Rings KW - 0 KW - RNA, Messenger KW - Tumor Suppressor Protein p53 KW - WMC-79 KW - Index Medicus KW - Microscopy, Confocal KW - Blotting, Western KW - Humans KW - Cell Line, Tumor KW - HCT116 Cells KW - RNA, Messenger -- genetics KW - Gene Expression Regulation, Neoplastic -- drug effects KW - RNA, Messenger -- biosynthesis KW - Cell Cycle -- drug effects KW - Tumor Suppressor Protein p53 -- physiology KW - Colonic Neoplasms -- genetics KW - Colonic Neoplasms -- drug therapy KW - Apoptosis -- drug effects KW - Heterocyclic Compounds, 4 or More Rings -- pharmacology KW - Colonic Neoplasms -- metabolism KW - Heterocyclic Compounds, 4 or More Rings -- pharmacokinetics KW - Colonic Neoplasms -- pathology KW - Tumor Suppressor Protein p53 -- deficiency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68696927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=WMC-79%2C+a+potent+agent+against+colon+cancers%2C+induces+apoptosis+through+a+p53-dependent+pathway.&rft.au=Kosakowska-Cholody%2C+Teresa%3BCholody%2C+W+Marek%3BMonks%2C+Anne%3BWoynarowska%2C+Barbara+A%3BMichejda%2C+Christopher+J&rft.aulast=Kosakowska-Cholody&rft.aufirst=Teresa&rft.date=2005-10-01&rft.volume=4&rft.issue=10&rft.spage=1617&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-18 N1 - Date created - 2005-10-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Suppression of tumor cell invasion by cyclooxygenase inhibitors is mediated by thrombospondin-1 via the early growth response gene Egr-1. AN - 68696277; 16227405 AB - Cyclooxygenase (COX) inhibitors have antitumorigenic activity and increase the expression of the early growth response gene Egr-1, a tumor suppressor gene and transcription factor. In this study, we have investigated the gene regulatory and anti-invasive activity of two traditional nonsteroidal anti-inflammatory drugs (NSAID), sulindac sulfide and indomethacin. These compounds inhibited tumor cell invasion and induced Egr-1 expression in lung adenocarcinoma A549 cells. Overexpression of Egr-1 reduced cellular invasion in the Matrigel system, whereas suppression of Egr-1 by small interference RNA (siRNA) attenuated the inhibition of Matrigel invasion by these compounds, indicating that Egr-1 is responsible for the decrease in invasion reported following treatment with NSAIDs. Egr-1-overexpressing cells were analyzed for genes involved in invasion and metastasis. Thrombospondin-1 (TSP-1) an antiangiogenic and anti-invasion protein was up-regulated by Egr-1 overexpression, which was confirmed following treatment with sulindac sulfide. Furthermore, the induction of TSP-1 by sulindac sulfide was blocked by Egr-1 siRNA. When TSP-1 was sequestered by the addition of anti-TSP-1 antibody, the inhibition of invasion by sulindac sulfide was attenuated, indicating that TSP-1 is involved in the inhibition of invasion by NSAIDs. We used the Min mouse model to determine if sulindac sulfide would increase Egr-1 and TSP-1 in vivo, because this model is widely used to study the effects of NSAIDs on tumor formation. Treatment of Min mice with concentrations of sulindac sulfide that inhibit tumor formation increased the expression of Egr-1 and TSP-1 in colonic tissues and in the polyps of these mice. This is the first report suggesting that COX inhibitors suppress tumor cell invasion via TSP-1, which occurs downstream of Egr-1. JF - Molecular cancer therapeutics AU - Moon, Yuseok AU - Bottone, Frank G AU - McEntee, Michael F AU - Eling, Thomas E AD - Eicosanoid Biochemistry Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA. Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 1551 EP - 1558 VL - 4 IS - 10 SN - 1535-7163, 1535-7163 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Cyclooxygenase Inhibitors KW - Early Growth Response Protein 1 KW - RNA, Messenger KW - RNA, Small Interfering KW - Thrombospondin 1 KW - Sulindac KW - 184SNS8VUH KW - sulindac sulfide KW - 6UVA8S2DEY KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Neoplasm Invasiveness KW - Animals KW - Humans KW - Sulindac -- pharmacology KW - Sulindac -- analogs & derivatives KW - RNA, Small Interfering -- genetics KW - Mice KW - Cell Line, Tumor KW - RNA, Messenger -- genetics KW - RNA, Messenger -- biosynthesis KW - Indomethacin -- pharmacology KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology KW - Adenocarcinoma -- metabolism KW - Colorectal Neoplasms -- metabolism KW - Lung Neoplasms -- drug therapy KW - Thrombospondin 1 -- metabolism KW - Early Growth Response Protein 1 -- genetics KW - Adenocarcinoma -- genetics KW - Colorectal Neoplasms -- genetics KW - Colorectal Neoplasms -- drug therapy KW - Thrombospondin 1 -- biosynthesis KW - Adenocarcinoma -- pathology KW - Cyclooxygenase Inhibitors -- pharmacology KW - Genes, Tumor Suppressor -- drug effects KW - Colorectal Neoplasms -- pathology KW - Early Growth Response Protein 1 -- biosynthesis KW - Lung Neoplasms -- genetics KW - Genes, Tumor Suppressor -- physiology KW - Adenocarcinoma -- drug therapy KW - Lung Neoplasms -- pathology KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68696277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Suppression+of+tumor+cell+invasion+by+cyclooxygenase+inhibitors+is+mediated+by+thrombospondin-1+via+the+early+growth+response+gene+Egr-1.&rft.au=Moon%2C+Yuseok%3BBottone%2C+Frank+G%3BMcEntee%2C+Michael+F%3BEling%2C+Thomas+E&rft.aulast=Moon&rft.aufirst=Yuseok&rft.date=2005-10-01&rft.volume=4&rft.issue=10&rft.spage=1551&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-18 N1 - Date created - 2005-10-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Advances in antifungal therapy. AN - 68688461; 16220093 JF - The Pediatric infectious disease journal AU - Pannaraj, Pia S AU - Walsh, Thomas J AU - Baker, Carol J AD - National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 921 EP - 922 VL - 24 IS - 10 SN - 0891-3668, 0891-3668 KW - Antifungal Agents KW - 0 KW - ER 30346 KW - Echinocandins KW - Fungal Proteins KW - Lipopeptides KW - Lipoproteins KW - Peptides, Cyclic KW - Pyrimidines KW - Thiazoles KW - Triazoles KW - echinocandin B KW - 54651-05-7 KW - posaconazole KW - 6TK1G07BHZ KW - anidulafungin KW - 9HLM53094I KW - caspofungin KW - F0XDI6ZL63 KW - Voriconazole KW - JFU09I87TR KW - micafungin KW - R10H71BSWG KW - Index Medicus KW - Fungal Proteins -- therapeutic use KW - Pyrimidines -- adverse effects KW - Animals KW - Lipoproteins -- pharmacology KW - Pyrimidines -- therapeutic use KW - Lipoproteins -- therapeutic use KW - Humans KW - Lipoproteins -- adverse effects KW - Aged KW - Child KW - Infant KW - Peptides, Cyclic -- therapeutic use KW - Aged, 80 and over KW - Adult KW - Treatment Outcome KW - Fungal Proteins -- adverse effects KW - Triazoles -- therapeutic use KW - Peptides, Cyclic -- pharmacokinetics KW - Fungal Proteins -- pharmacology KW - Adolescent KW - Peptides, Cyclic -- pharmacology KW - Peptides, Cyclic -- adverse effects KW - Clinical Trials as Topic KW - Infant, Newborn KW - Pyrimidines -- pharmacology KW - Triazoles -- pharmacology KW - Triazoles -- adverse effects KW - Thiazoles -- adverse effects KW - Pyrimidines -- pharmacokinetics KW - Triazoles -- pharmacokinetics KW - Child, Preschool KW - Thiazoles -- pharmacology KW - Middle Aged KW - Thiazoles -- therapeutic use KW - Antifungal Agents -- pharmacokinetics KW - Antifungal Agents -- adverse effects KW - Mycoses -- microbiology KW - Mycoses -- drug therapy KW - Antifungal Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68688461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Pediatric+infectious+disease+journal&rft.atitle=Advances+in+antifungal+therapy.&rft.au=Pannaraj%2C+Pia+S%3BWalsh%2C+Thomas+J%3BBaker%2C+Carol+J&rft.aulast=Pannaraj&rft.aufirst=Pia&rft.date=2005-10-01&rft.volume=24&rft.issue=10&rft.spage=921&rft.isbn=&rft.btitle=&rft.title=The+Pediatric+infectious+disease+journal&rft.issn=08913668&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-05 N1 - Date created - 2005-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Proteomic signature of myeloproliferation and neutrophilia: analysis of serum and plasma from healthy subjects given granulocyte colony-stimulating factor. AN - 68681850; 16219533 AB - Proteomic analysis could improve our understanding of the mechanisms and consequences of myeloproliferation. Healthy subjects treated with granulocyte colony-stimulating factor (G-CSF) were used as a model of myeloproliferation. Levels of 80 soluble factors were measured by enzyme-linked immunosorbent assay before and after 5 days of G-CSF. Both serum and plasma levels were measured to generate a comprehensive profile and determine whether serum or plasma best portrays biological and physiological changes. Comparison of samples collected prior to G-CSF demonstrated that 44 factors differed between serum and plasma. Concentrations of several growth factors and chemokines were greater in serum than in plasma, while the opposite was true for several interleukins. Following G-CSF serum levels of 14 factors and plasma levels of 15 factors changed. Eleven increased in both serum and plasma, including cell adhesion molecules (vascular cell adhesion molecule-1, E-selectin, and L-selectin), matrix metalloproteases (MMP-1, -8, and -13), cytokine receptors (tumor necrosis factor receptor 1 and 2, and interleukin-2 receptor), the acute phase reactant, serum amyloid A, and a growth factor, hepatocyte growth factor. Some protein levels differ markedly in serum and plasma. Myeloproliferation is associated with changes in the levels of several proteases, adhesion molecules, and cytokines. JF - Experimental hematology AU - Stroncek, David AU - Slezak, Stefanie AU - Khuu, Hanh AU - Basil, Christopher AU - Tisdale, John AU - Leitman, Susan F AU - Marincola, Francesco M AU - Panelli, Monica C AD - Department of Transfusion Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. dstroncek@cc.nih.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 1109 EP - 1117 VL - 33 IS - 10 SN - 0301-472X, 0301-472X KW - Blood Proteins KW - 0 KW - Recombinant Proteins KW - Granulocyte Colony-Stimulating Factor KW - 143011-72-7 KW - Filgrastim KW - PVI5M0M1GW KW - Index Medicus KW - Enzyme-Linked Immunosorbent Assay -- methods KW - Humans KW - Male KW - Female KW - Granulocyte Colony-Stimulating Factor -- blood KW - Leukocytosis -- chemically induced KW - Leukocytosis -- blood KW - Granulocyte Colony-Stimulating Factor -- administration & dosage KW - Blood Proteins -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68681850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+hematology&rft.atitle=Proteomic+signature+of+myeloproliferation+and+neutrophilia%3A+analysis+of+serum+and+plasma+from+healthy+subjects+given+granulocyte+colony-stimulating+factor.&rft.au=Stroncek%2C+David%3BSlezak%2C+Stefanie%3BKhuu%2C+Hanh%3BBasil%2C+Christopher%3BTisdale%2C+John%3BLeitman%2C+Susan+F%3BMarincola%2C+Francesco+M%3BPanelli%2C+Monica+C&rft.aulast=Stroncek&rft.aufirst=David&rft.date=2005-10-01&rft.volume=33&rft.issue=10&rft.spage=1109&rft.isbn=&rft.btitle=&rft.title=Experimental+hematology&rft.issn=0301472X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-02 N1 - Date created - 2005-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Targeting the epigenome for the treatment and prevention of lung cancer. AN - 68673352; 16210090 AB - Alterations in chromatin structure resulting from aberrant DNA methylation and perturbations of the histone code profoundly influence gene expression during pulmonary carcinogenesis. Recent studies indicate that DNA demethylating agents and histone deacetylase (HDAC) inhibitors synergistically induce gene expression and apoptosis in cultured lung cancer cells, and prevent lung cancer development in animals following exposure to tobacco carcinogens. Preliminary clinical trials have established proof of principle regarding the use of DNA demethylating agents and HDAC inhibitors for enhancing immunogenicity and apoptosis of lung cancer cells, and have revealed the complexities concerning the mechanisms by which chromatin remodeling agents mediate antitumor effects in vivo. These data support additional investigations pertaining to the epigenetics of lung cancer, and the evaluation of chromatin remodeling agents for the treatment and prevention of this disease. JF - Seminars in oncology AU - Schrump, David S AU - Nguyen, Dao M AD - Thoracic Oncology Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892-1201, USA. David_Schrump@nih.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 488 EP - 502 VL - 32 IS - 5 SN - 0093-7754, 0093-7754 KW - Antineoplastic Agents KW - 0 KW - Chromatin KW - Enzyme Inhibitors KW - Histone Deacetylase Inhibitors KW - Histones KW - Index Medicus KW - Animals KW - Apoptosis KW - Chromatin -- metabolism KW - Humans KW - Clinical Trials as Topic KW - Cell Line, Tumor KW - DNA Methylation KW - Histones -- metabolism KW - Enzyme Inhibitors -- pharmacology KW - Flow Cytometry KW - Time Factors KW - Antineoplastic Agents -- pharmacology KW - Gene Expression Regulation, Neoplastic KW - Lung Neoplasms -- prevention & control KW - Lung Neoplasms -- drug therapy KW - Lung Neoplasms -- genetics KW - Epigenesis, Genetic KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68673352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+oncology&rft.atitle=Targeting+the+epigenome+for+the+treatment+and+prevention+of+lung+cancer.&rft.au=Schrump%2C+David+S%3BNguyen%2C+Dao+M&rft.aulast=Schrump&rft.aufirst=David&rft.date=2005-10-01&rft.volume=32&rft.issue=5&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=Seminars+in+oncology&rft.issn=00937754&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-08 N1 - Date created - 2005-10-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors. AN - 68668607; 16170321 AB - Tumor necrosis factor (TNF)-alpha has an important role in the pathogenesis of autoimmune and inflammatory diseases such as rheumatoid and septic arthritis. The biological effects of TNF-alpha are mediated by binding to TNF receptors TNFR1 (also known as P60) or TNFR2 (also known as P80). The pre-ligand assembly domain (PLAD) is a portion of the extracellular region of TNFRs that mediates receptor-chain association essential for signaling. We found that soluble versions of PLAD, especially those derived from P60, block the biochemical effects of TNF-alpha in vitro and potently inhibit arthritis in animal models. Thus, targeting the PLAD may have clinical value in the treatment of human arthritis and other disorders involving receptors of the TNFR superfamily. JF - Nature medicine AU - Deng, Guo-Min AU - Zheng, Lixin AU - Chan, Francis Ka-Ming AU - Lenardo, Michael AD - Laboratory of Immunology, Building 10, Room 11N311, 10 Center Drive, MSC 1892, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 1066 EP - 1072 VL - 11 IS - 10 SN - 1078-8956, 1078-8956 KW - Ligands KW - 0 KW - Receptors, Tumor Necrosis Factor KW - Receptors, Tumor Necrosis Factor, Type I KW - Receptors, Tumor Necrosis Factor, Type II KW - Recombinant Fusion Proteins KW - Tumor Necrosis Factor-alpha KW - Collagen KW - 9007-34-5 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Receptors, Tumor Necrosis Factor, Type I -- antagonists & inhibitors KW - Animals KW - Receptors, Tumor Necrosis Factor, Type I -- therapeutic use KW - DNA -- pharmacology KW - Mice KW - Receptors, Tumor Necrosis Factor, Type I -- chemistry KW - Mice, Transgenic KW - Cell Death -- drug effects KW - Receptors, Tumor Necrosis Factor, Type II -- metabolism KW - Binding Sites KW - Mice, Knockout KW - Recombinant Fusion Proteins -- metabolism KW - Receptors, Tumor Necrosis Factor, Type II -- therapeutic use KW - Receptors, Tumor Necrosis Factor, Type I -- metabolism KW - Binding, Competitive KW - DNA -- genetics KW - Recombinant Fusion Proteins -- genetics KW - CpG Islands -- genetics KW - Receptors, Tumor Necrosis Factor, Type II -- antagonists & inhibitors KW - Protein Structure, Tertiary KW - Receptors, Tumor Necrosis Factor, Type II -- chemistry KW - Cell Line KW - Arthritis -- pathology KW - Receptors, Tumor Necrosis Factor -- therapeutic use KW - Receptors, Tumor Necrosis Factor -- metabolism KW - Arthritis -- chemically induced KW - Tumor Necrosis Factor-alpha -- metabolism KW - Arthritis -- drug therapy KW - Receptors, Tumor Necrosis Factor -- antagonists & inhibitors KW - Receptors, Tumor Necrosis Factor -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68668607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+medicine&rft.atitle=Amelioration+of+inflammatory+arthritis+by+targeting+the+pre-ligand+assembly+domain+of+tumor+necrosis+factor+receptors.&rft.au=Deng%2C+Guo-Min%3BZheng%2C+Lixin%3BChan%2C+Francis+Ka-Ming%3BLenardo%2C+Michael&rft.aulast=Deng&rft.aufirst=Guo-Min&rft.date=2005-10-01&rft.volume=11&rft.issue=10&rft.spage=1066&rft.isbn=&rft.btitle=&rft.title=Nature+medicine&rft.issn=10788956&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-07 N1 - Date created - 2005-10-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Therapeutics development for triplet repeat expansion diseases. AN - 68664747; 16205715 AB - The underlying genetic mutations for many inherited neurodegenerative disorders have been identified in recent years. One frequent type of mutation is trinucleotide repeat expansion. Depending on the location of the repeat expansion, the mutation might result in a loss of function of the disease gene, a toxic gain of function or both. Disease gene identification has led to the development of model systems for investigating disease mechanisms and evaluating treatments. Examination of experimental findings reveals similarities in disease mechanisms as well as possibilities for treatment. JF - Nature reviews. Genetics AU - Di Prospero, Nicholas A AU - Fischbeck, Kenneth H AD - Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-3705, USA. DiProsperN@ninds.nih.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 756 EP - 765 VL - 6 IS - 10 SN - 1471-0056, 1471-0056 KW - Peptides KW - 0 KW - polyalanine KW - 25191-17-7 KW - polyglutamine KW - 26700-71-0 KW - Index Medicus KW - Fragile X Syndrome -- genetics KW - Humans KW - Gene Expression Regulation KW - Peptides -- genetics KW - Huntington Disease -- genetics KW - Trinucleotide Repeats KW - Heredodegenerative Disorders, Nervous System -- therapy KW - Heredodegenerative Disorders, Nervous System -- genetics KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68664747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+reviews.+Genetics&rft.atitle=Therapeutics+development+for+triplet+repeat+expansion+diseases.&rft.au=Di+Prospero%2C+Nicholas+A%3BFischbeck%2C+Kenneth+H&rft.aulast=Di+Prospero&rft.aufirst=Nicholas&rft.date=2005-10-01&rft.volume=6&rft.issue=10&rft.spage=756&rft.isbn=&rft.btitle=&rft.title=Nature+reviews.+Genetics&rft.issn=14710056&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-10-19 N1 - Date created - 2005-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fundamental flaws of hormesis for public health decisions. AN - 68663711; 16203233 AB - Hormesis (defined operationally as low-dose stimulation, high-dose inhibition) is often used to promote the notion that while high-level exposures to toxic chemicals could be detrimental to human health, low-level exposures would be beneficial. Some proponents claim hormesis is an adaptive, generalizable phenomenon and argue that the default assumption for risk assessments should be that toxic chemicals induce stimulatory (i.e., "beneficial") effects at low exposures. In many cases, nonmonotonic dose-response curves are called hormetic responses even in the absence of any mechanistic characterization of that response. Use of the term "hormesis," with its associated descriptors, distracts from the broader and more important questions regarding the frequency and interpretation of nonmonotonic dose responses in biological systems. A better understanding of the biological basis and consequences of nonmonotonic dose-response curves is warranted for evaluating human health risks. The assumption that hormesis is generally adaptive is an oversimplification of complex biological processes. Even if certain low-dose effects were sometimes considered beneficial, this should not influence regulatory decisions to allow increased environmental exposures to toxic and carcinogenic agents, given factors such as interindividual differences in susceptibility and multiplicity in exposures. In this commentary we evaluate the hormesis hypothesis and potential adverse consequences of incorporating low-dose beneficial effects into public health decisions. Key words: biphasic dose response, hormesis, individual susceptibility, low-dose exposures, nonmonotonic dose response, nonlinear dose response, public health, regulation, risk assessment. JF - Environmental health perspectives AU - Thayer, Kristina A AU - Melnick, Ronald AU - Burns, Kathy AU - Davis, Devra AU - Huff, James AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. thayer@niehs.nih.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 1271 EP - 1276 VL - 113 IS - 10 SN - 0091-6765, 0091-6765 KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Health Status KW - Occupational Exposure KW - Public Health KW - Environmental Exposure KW - Decision Making, Organizational UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68663711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Fundamental+flaws+of+hormesis+for+public+health+decisions.&rft.au=Thayer%2C+Kristina+A%3BMelnick%2C+Ronald%3BBurns%2C+Kathy%3BDavis%2C+Devra%3BHuff%2C+James&rft.aulast=Thayer&rft.aufirst=Kristina&rft.date=2005-10-01&rft.volume=113&rft.issue=10&rft.spage=1271&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-23 N1 - Date created - 2005-10-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Fam Pract. 2004 Feb;53(2):146-50 [14764301] Toxicol Appl Pharmacol. 1978 Nov;46(2):279-303 [734660] Acta Oncol. 2003;42(8):809-15 [14968941] BMJ. 2004 Feb 21;328(7437):434 [14976098] Environ Sci Technol. 2004 Mar 1;38(5):90A-95A [15046324] JAMA. 2004 Apr 28;291(16):1987-93 [15113817] Environ Health Perspect. 2004 Jul;112(10):1099-103 [15238284] Br J Pharmacol. 1980 May;69(1):151-7 [6247004] Obstet Gynecol. 1981 Nov;58(5 Suppl):35S-40S [7031540] Leuk Res. 1986;10(7):749-54 [3736109] Am J Clin Nutr. 1987 Jan;45(1 Suppl):252-60 [3799516] Radiat Res. 1988 Feb;113(2):300-17 [3340735] Cancer Res. 1988 Aug 15;48(16):4656-63 [3396014] JAMA. 1990 Aug 1;264(5):605-9 [2366301] Chem Res Toxicol. 1991 Mar-Apr;4(2):168-79 [1664256] Health Phys. 1995 Feb;68(2):157-74 [7814250] Toxicol Appl Pharmacol. 1997 Jan;142(1):40-6 [9007032] Int J Radiat Biol. 1998 Aug;74(2):159-71 [9712546] Toxicol Sci. 1999 Feb;47(2):135-43 [10220849] J Natl Cancer Inst. 1964 Nov;33:855-65 [14231158] J Natl Cancer Inst. 1963 Aug;31:425-55 [14046632] Hum Exp Toxicol. 1999 Nov;18(11):653-8 [10602389] Radiat Res. 2000 May;153(5 Pt 1):557-69 [10790277] Br J Cancer. 2001 Jan 5;84(1):126-33 [11139327] Toxicol Sci. 2001 Aug;62(2):330-8 [11452146] Pediatrics. 2001 Aug;108(2):E34 [11483844] Toxicol Sci. 2002 Apr;66(2):185-200 [11896285] Environ Res. 2002 Mar;88(3):156-63 [12051793] Hum Exp Toxicol. 2002 Feb;21(2):91-7 [12102503] Trends Pharmacol Sci. 2002 Jul;23(7):331-7 [12119154] Alcohol Alcohol. 2002 Sep-Oct;37(5):409-15 [12217928] Toxicol Appl Pharmacol. 2002 Aug 15;183(1):10-22 [12217638] Annu Rev Pharmacol Toxicol. 2003;43:175-97 [12195028] Diabetes Care. 2003 Feb;26(2):468-70 [12547882] Nature. 2003 Feb 13;421(6924):691-2 [12610596] Mol Pharmacol. 2003 Apr;63(4):945-56 [12644596] Fed Regist. 2003 Apr 17;68(74):18861-9 [12701599] Health Phys. 2003 Apr;84(4):526-32 [12705451] Arch Biochem Biophys. 2003 May 15;413(2):213-20 [12729619] Crit Rev Toxicol. 2003;33(3-4):355-405 [12809429] Biol Trace Elem Res. 2003 Summer;93(1-3):189-200 [12835501] Hum Exp Toxicol. 2003 Jun;22(6):290-306; discussion 307, 315-7, 319-23 [12856953] Environ Health Perspect. 2003 Aug;111(11):1403-9 [12928148] Science. 2003 Oct 17;302(5644):376-9 [14563981] Science. 2003 Oct 17;302(5644):378 [14563982] Environ Health Perspect. 2003 Nov;111(14):1723-9 [14594622] JAMA. 2003 Dec 10;290(22):2996-9 [14665662] BMJ. 2004 Jan 3;328(7430):19 [14703539] Environ Health Perspect. 2004 Aug;112(11):1152-8 [15289159] Clin Pharmacol Ther. 1973 Jan-Feb;14(1):41-7 [4734200] Int J Mol Med. 2004 Mar;13(3):445-50 [14767577] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The need for exposure health sciences. AN - 68659506; 16203220 JF - Environmental health perspectives AU - Schwartz, David A AU - Weis, Brenda AU - Wilson, Samuel H AD - NIEHS, Durham, North Carolina, USA. Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 1 VL - 113 IS - 10 SN - 0091-6765, 0091-6765 KW - Index Medicus KW - Genome, Human KW - Humans KW - Research KW - Risk Assessment KW - Health Status KW - Environmental Exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68659506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=The+need+for+exposure+health+sciences.&rft.au=Schwartz%2C+David+A%3BWeis%2C+Brenda%3BWilson%2C+Samuel+H&rft.aulast=Schwartz&rft.aufirst=David&rft.date=2005-10-01&rft.volume=113&rft.issue=10&rft.spage=A650&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-23 N1 - Date created - 2005-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Carboxylesterase isoform 2 mRNA expression in peripheral blood mononuclear cells is a predictive marker of the irinotecan to SN38 activation step in colorectal cancer patients. AN - 68655438; 16203781 AB - Irinotecan (CPT11) is a prodrug activated in humans mainly by carboxylesterase 2 (CES2) generating the SN38 metabolite responsible for the drug efficacy and toxicity. The interpatients variability in CPT11 activation step could cause unpredictable toxicity. To identify a predictive molecular marker for CPT11 activation in cancer patients, we investigated the CES2 mRNA expression in peripheral blood mononuclear cells (PBMC) and correlated it to CPT11 activation rate, toxic effects, and response. Forty-five colorectal cancer patients were treated with a CPT11-including regimen (FOLFIRI). CES2 mRNA expression in PBMC was quantified by reverse transcription-PCR in real time. Plasma concentrations of CPT11, SN38, and SN38-glucuronide were determined by high-performance liquid chromatography and the pharmacokinetic variables calculated adopting the noncompartmental model. Toxicity was evaluated by the National Cancer Institute Common Toxicity Criteria scale and response by the WHO criteria. A high interindividual variability in CES2 mRNA relative expression was observed (median, 1.45; range, 0.01-28.21). CES2 mRNA expression level was significantly associated with CPT11 activation ratio [(AUC(SN38) + AUC(SN38G))/AUC(CPT11)]. Patients with CES2 mRNA expression above the median cutoff value presented an activation ratio higher (median, 0.25; range, 0.15-0.42) than those with CES2 mRNA below the median (median, 0.20; range, 0.10-0.40; P = 0.013). This was associated with a nonsignificant trend of 1.34-fold increase of SN38 AUC in the group of patients with high CES2 mRNA expression (mean, 1.03 +/- 0.62 versus 0.77 +/- 0.32 micromol/L hour). Eight of 23 high CES2 mRNA-expressing patients (34.8%) developed grade 3 to 4 neutropenia or diarrhea compared with 2 of 22 (9.1%) in the low CES2-expressing group (P = 0.071). Our data support a predictive power of CES2 mRNA expression in PBMC for the activation rate of CPT11. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Cecchin, Erika AU - Corona, Giuseppe AU - Masier, Sara AU - Biason, Paola AU - Cattarossi, Giulio AU - Frustaci, Sergio AU - Buonadonna, Angela AU - Colussi, Annamaria AU - Toffoli, Giuseppe AD - Experimental and Clinical Pharmacology, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy. Y1 - 2005/10/01/ PY - 2005 DA - 2005 Oct 01 SP - 6901 EP - 6907 VL - 11 IS - 19 Pt 1 SN - 1078-0432, 1078-0432 KW - Protein Isoforms KW - 0 KW - RNA, Messenger KW - irinotecan KW - 0H43101T0J KW - Carboxylesterase KW - EC 3.1.1.1 KW - DNA Topoisomerases, Type I KW - EC 5.99.1.2 KW - Leucovorin KW - Q573I9DVLP KW - Fluorouracil KW - U3P01618RT KW - Camptothecin KW - XT3Z54Z28A KW - Index Medicus KW - Area Under Curve KW - Humans KW - Leucovorin -- administration & dosage KW - Aged KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Reverse Transcriptase Polymerase Chain Reaction KW - Chromatography, High Pressure Liquid KW - Fluorouracil -- administration & dosage KW - Kinetics KW - Middle Aged KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Time Factors KW - DNA Topoisomerases, Type I -- metabolism KW - Female KW - Male KW - RNA, Messenger -- metabolism KW - Camptothecin -- pharmacology KW - Colorectal Neoplasms -- metabolism KW - Leukocytes, Mononuclear -- metabolism KW - Camptothecin -- analogs & derivatives KW - Colorectal Neoplasms -- drug therapy KW - Leukocytes, Mononuclear -- cytology KW - Camptothecin -- administration & dosage KW - Carboxylesterase -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68655438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Carboxylesterase+isoform+2+mRNA+expression+in+peripheral+blood+mononuclear+cells+is+a+predictive+marker+of+the+irinotecan+to+SN38+activation+step+in+colorectal+cancer+patients.&rft.au=Cecchin%2C+Erika%3BCorona%2C+Giuseppe%3BMasier%2C+Sara%3BBiason%2C+Paola%3BCattarossi%2C+Giulio%3BFrustaci%2C+Sergio%3BBuonadonna%2C+Angela%3BColussi%2C+Annamaria%3BToffoli%2C+Giuseppe&rft.aulast=Cecchin&rft.aufirst=Erika&rft.date=2005-10-01&rft.volume=11&rft.issue=19+Pt+1&rft.spage=6901&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-08 N1 - Date created - 2005-10-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Clin Cancer Res. 2006 Mar 15;12(6):1942; author reply 1942-3 [16551882] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regulating SWI/SNF subunit levels via protein-protein interactions and proteasomal degradation: BAF155 and BAF170 limit expression of BAF57. AN - 68654957; 16199878 AB - The mammalian SWI/SNF chromatin remodeling complex, whose function is of critical importance in transcriptional regulation, contains approximately 10 protein components. The expression levels of the core SWI/SNF subunits, including BRG1/Brm, BAF155, BAF170, BAF60, hSNF/Ini1, and BAF57, are stoichiometric, with few to no unbound molecules in the cell. Here we report that exogenous expression of the wild type or certain deletion mutants of BAF57, a key subunit that mediates the interaction between the remodeling complex and transcription factors, results in diminished expression of endogenous BAF57. This down-regulation process is mediated by an increase in proteasome-dependent degradation of the BAF57 protein. Furthermore, the protein levels of BAF155/170 dictate the maximum cellular amount of BAF57. We mapped the domains responsible for the interaction between BAF57 and BAF155 and demonstrated that protein-protein interactions between them play an important role in this regulatory process. These findings provide insights into the physiological mechanisms responsible for maintaining the proper stoichiometric levels of the protein components comprising multimeric enzyme complexes. JF - Molecular and cellular biology AU - Chen, Jianguang AU - Archer, Trevor K AD - Chromatin and Gene Expression Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 9016 EP - 9027 VL - 25 IS - 20 SN - 0270-7306, 0270-7306 KW - Chromosomal Proteins, Non-Histone KW - 0 KW - DNA-Binding Proteins KW - Multiprotein Complexes KW - Protein Subunits KW - Recombinant Proteins KW - SMARCC1 protein, human KW - SMARCC2 protein, human KW - SMARCE1 protein, human KW - Transcription Factors KW - DNA KW - 9007-49-2 KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Index Medicus KW - Humans KW - Recombinant Proteins -- genetics KW - Protein Binding KW - Base Sequence KW - Down-Regulation KW - Proteasome Endopeptidase Complex -- metabolism KW - Recombinant Proteins -- metabolism KW - DNA -- genetics KW - Recombinant Proteins -- chemistry KW - Protein Structure, Tertiary KW - Cell Line KW - Sequence Deletion KW - DNA-Binding Proteins -- chemistry KW - Transcription Factors -- metabolism KW - Transcription Factors -- chemistry KW - DNA-Binding Proteins -- genetics KW - Transcription Factors -- genetics KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68654957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Regulating+SWI%2FSNF+subunit+levels+via+protein-protein+interactions+and+proteasomal+degradation%3A+BAF155+and+BAF170+limit+expression+of+BAF57.&rft.au=Chen%2C+Jianguang%3BArcher%2C+Trevor+K&rft.aulast=Chen&rft.aufirst=Jianguang&rft.date=2005-10-01&rft.volume=25&rft.issue=20&rft.spage=9016&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-21 N1 - Date created - 2005-10-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2002 Jul 11;418(6894):195-9 [12110891] Curr Opin Genet Dev. 2002 Feb;12(1):73-9 [11790558] Genome Biol. 2002 Jul 24;3(8):RESEARCH0039 [12186646] Nat Struct Biol. 2003 Feb;10(2):141-5 [12524530] Rev Med Virol. 2003 Mar-Apr;13(2):99-110 [12627393] Curr Opin Genet Dev. 2003 Apr;13(2):136-42 [12672490] J Biol Chem. 2003 May 16;278(20):17876-84 [12637547] Mol Cell Biol. 2003 Nov;23(21):7475-87 [14559996] Nature. 2003 Dec 18;426(6968):895-9 [14685250] J Biol Chem. 2004 Feb 6;279(6):4180-5 [14630919] Nat Rev Mol Cell Biol. 2004 Feb;5(2):158-63 [15040448] Mol Cell Biol. 2004 Apr;24(8):3347-58 [15060156] Genes Dev. 2004 Mar 15;18(6):602-16 [15075289] Oncogene. 2004 Apr 22;23(19):3462-73 [14990991] Mol Cell Biol. 2004 Jun;24(11):4651-63 [15143161] Genes Dev. 2004 Aug 1;18(15):1862-74 [15289458] Biochimie. 1994;76(9):867-79 [7880904] Genes Dev. 1996 Sep 1;10(17):2117-30 [8804307] Trends Biochem Sci. 1996 Mar;21(3):87-8 [8882580] EMBO J. 1996 Oct 1;15(19):5370-82 [8895581] Proc Natl Acad Sci U S A. 1998 Jan 20;95(2):492-8 [9435219] Nature. 1998 May 7;393(6680):88-91 [9590696] Cell. 1998 Jul 24;94(2):217-27 [9695950] EMBO J. 1998 Dec 1;17(23):6979-91 [9843504] RNA. 1999 Mar;5(3):409-19 [10094309] Nat Genet. 2005 Mar;37(3):254-64 [15696166] Mol Cell Biol. 2005 Mar;25(6):2200-15 [15743818] Cell. 2005 Mar 25;120(6):803-15 [15797381] J Mol Endocrinol. 2005 Apr;34(2):281-97 [15821097] Mol Cell Biol. 2005 May;25(10):3997-4009 [15870273] Mol Cell Biol. 2000 Mar;20(6):1899-910 [10688638] J Biol Chem. 2000 Jun 9;275(23):17771-7 [10748103] J Cell Physiol. 2001 Jan;186(1):136-45 [11147808] Proc Natl Acad Sci U S A. 2001 May 8;98(10):5728-33 [11331758] Oncogene. 2001 May 28;20(24):3067-75 [11420722] Chem Biol. 2001 Aug;8(8):739-58 [11514224] EMBO J. 2002 Aug 1;21(15):4094-103 [12145209] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - N-methyl-D-aspartate subunit expression during mouse development altered by in utero alcohol exposure. AN - 68651465; 16202752 AB - Alcohol-related neurodevelopmental disorders are contributors to long-term learning disabilities. By using a model for fetal alcohol syndrome, we have shown that prenatal alcohol exposure results in adult learning deficits of unknown mechanisms. In the developing hippocampus, the N-methyl-D-aspartate (NMDA) receptor subunit NR2B triggers long-term potentiation, fundamental to learning and memory; this is supplemented by the less plastic NR2A subunit in the adult. To understand the mechanism of learning deficits in FAS, we evaluated NR2B and NR2A expression in embryonic and adult mice. Pregnant C57Bl6/J mice were treated on gestational day 8 with alcohol or control (saline solution). Embryos were harvested at 6 hours, 24 hours, and 10 days, and brains from adult offspring were collected at 3 months (after evaluation for learning deficit). Calibrator-normalized relative real-time polymerase chain reaction was performed for NR2B and NR2A with glyceraldehyde-3-phosphate dehydrogenase standardization. Statistical analysis included analysis of variance. At 6 hours, NR2B expression in the alcohol-exposed embryos was higher than in controls (P < .01). NR2A was not expressed in either group. By 24 hours there was no difference in NR2B (P = .3). However, at 10 days NR2B was lower in alcohol-exposed animals (P = .02). In the adult brains there was a relative decrease in NR2B (P = .03) and an increase in NR2A (P < .01). Prenatal alcohol exposure during development induces NR2B expression deregulation in the embryos that persists until adulthood, when a relative increase in the less modifiable subunit NR2A occurs. This alteration in NMDA receptor subunits may underlie the learning abnormalities in fetal alcohol syndrome. JF - American journal of obstetrics and gynecology AU - Toso, Laura AU - Poggi, Sarah H AU - Abebe, Daniel AU - Roberson, Robin AU - Dunlap, Veronica AU - Park, Jane AU - Spong, Catherine Y AD - NICHD, National Institutes of Health, Bethesda, MD 20892-0925, USA. laura_toso@hotmail.com Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 1534 EP - 1539 VL - 193 IS - 4 KW - NR2A NMDA receptor KW - 0 KW - NR2B NMDA receptor KW - Receptors, N-Methyl-D-Aspartate KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Mice, Inbred C57BL KW - Fetal Development -- drug effects KW - Mice KW - Female KW - Pregnancy KW - Receptors, N-Methyl-D-Aspartate -- biosynthesis KW - Fetal Alcohol Spectrum Disorders -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68651465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+obstetrics+and+gynecology&rft.atitle=N-methyl-D-aspartate+subunit+expression+during+mouse+development+altered+by+in+utero+alcohol+exposure.&rft.au=Toso%2C+Laura%3BPoggi%2C+Sarah+H%3BAbebe%2C+Daniel%3BRoberson%2C+Robin%3BDunlap%2C+Veronica%3BPark%2C+Jane%3BSpong%2C+Catherine+Y&rft.aulast=Toso&rft.aufirst=Laura&rft.date=2005-10-01&rft.volume=193&rft.issue=4&rft.spage=1534&rft.isbn=&rft.btitle=&rft.title=American+journal+of+obstetrics+and+gynecology&rft.issn=1097-6868&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-19 N1 - Date created - 2005-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Medications development: successes and challenges. AN - 68617832; 16083966 AB - The National Institute on Drug Abuse has funded a medications program that has concentrated on the development of medications for opiate and cocaine dependence. Levomethadyl acetate (LAAM) and buprenorphine and buprenorphine/naloxone sublingual tablets were developed in conjunction with pharmaceutical partners and approved by the Food and Drug Administration. The remaining challenges for medications development for opiate dependence involves Phase IV studies in special populations, for example, pregnant opiate-dependent patients, and to translate neuroscience-based findings into treatments. Several marketed medications have shown initial efficacy to reduce cocaine use in well-controlled clinical trials. Disulfiram has been shown to reduce cocaine use in several clinical trials, while baclofen, modafinil, naltrexone, ondansetron, tiagabine, and topiramate have shown preliminary efficacy in initial clinical studies. Confirmatory studies of many of these medications is underway. More recently, the NIDA medications program has evaluated medications for their ability to reduce methamphetamine use. To date, no medications tested have shown efficacy to reduce methamphetamine use. Both marketed medications and investigational agents will be tested. Finally, NIDA has begun to test medications for efficacy to reduce cannabis use. Initial studies are underway. Both agonist and antagonist approaches will be evaluated. Additionally, medications will be tested in cannabis-dependent patients for the management of insomnia, withdrawal, and concurrent depression. JF - Pharmacology & therapeutics AU - Vocci, Frank AU - Ling, Walter AD - Division of Pharmacotherapies and Medical Consequences of Drug Abuse, National Institute on Drug Abuse, National Institutes of Health, 6001 Executive Boulevard, Ste 4123, MSC 9551, Bethesda, MD 20892, USA. fv6k@nih.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 94 EP - 108 VL - 108 IS - 1 SN - 0163-7258, 0163-7258 KW - Narcotic Antagonists KW - 0 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Animals KW - Humans KW - Methadone -- administration & dosage KW - Narcotic Antagonists -- therapeutic use KW - Substance-Related Disorders -- drug therapy KW - Substance-Related Disorders -- rehabilitation KW - Drug Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68617832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology+%26+therapeutics&rft.atitle=Medications+development%3A+successes+and+challenges.&rft.au=Vocci%2C+Frank%3BLing%2C+Walter&rft.aulast=Vocci&rft.aufirst=Frank&rft.date=2005-10-01&rft.volume=108&rft.issue=1&rft.spage=94&rft.isbn=&rft.btitle=&rft.title=Pharmacology+%26+therapeutics&rft.issn=01637258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-05 N1 - Date created - 2005-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drugs and alcohol: treating and preventing abuse, addiction and their medical consequences. AN - 68616853; 16098597 AB - Recent advances in the fields of genetics, molecular biology, behavioral neuropharmacology, and brain imaging have dramatically changed our understanding of the addictive process and why relapse occurs even in the face of catastrophic consequences. Addiction is now recognized as a chronic brain disease that involves complex interactions between repeated exposure to drugs, biological (i.e., genetic and developmental), and environmental (i.e., drug availability, social, and economic variables) factors. Its treatment, therefore, requires, in general, not only a long-term intervention but also a multipronged approach that addresses the psychiatric, medical, legal, and social consequences of addiction. Also, because addiction usually starts in adolescence or early adulthood and is frequently comorbid with mental illness, we need to expand our treatment interventions in this age group both for substance abuse and psychiatric disorders. JF - Pharmacology & therapeutics AU - Volkow, Nora D AU - Li, Ting-Kai AD - National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA. nvolkow@nida.nih.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 3 EP - 17 VL - 108 IS - 1 SN - 0163-7258, 0163-7258 KW - Index Medicus KW - Humans KW - Alcoholism -- therapy KW - Alcoholism -- prevention & control KW - Alcoholism -- complications KW - Substance-Related Disorders -- therapy KW - Brain -- drug effects KW - Substance-Related Disorders -- complications KW - Substance-Related Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68616853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology+%26+therapeutics&rft.atitle=Drugs+and+alcohol%3A+treating+and+preventing+abuse%2C+addiction+and+their+medical+consequences.&rft.au=Volkow%2C+Nora+D%3BLi%2C+Ting-Kai&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2005-10-01&rft.volume=108&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Pharmacology+%26+therapeutics&rft.issn=01637258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-05 N1 - Date created - 2005-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Charting a course for health services research at the National Institute on Drug Abuse. AN - 68608469; 16183465 AB - Through research, we continue to develop and refine an array of safe and efficacious interventions to prevent and treat drug abuse; however, these interventions have not led to widespread improvements in prevention and treatment services in nonresearch settings. In addition, investigator-initiated research rarely examine or refine interventions that practitioners have found relevant and that are widely practiced. To address these problems, the National Institute on Drug Abuse convened a blue ribbon task force to examine its health services research program. The report served as a catalyst for the institute to promote a vigorous program of research that seeks to examine prevention and treatment intervention delivery systems and policies that facilitate provision of effective care in a range of real world settings. Findings from this research should help address the translational bottleneck of bringing evidence-based interventions into the community. JF - Journal of substance abuse treatment AU - Compton, Wilson M AU - Stein, Jack B AU - Robertson, Elizabeth B AU - Pintello, Denise AU - Pringle, Beverly AU - Volkow, Nora D AD - National Institute on Drug Abuse, Bethesda, MD 20892-9589, USA. Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 167 EP - 172 VL - 29 IS - 3 SN - 0740-5472, 0740-5472 KW - Index Medicus KW - United States KW - Humans KW - Research Design KW - United States Substance Abuse and Mental Health Services Administration KW - Health Services Research KW - Health Planning Guidelines KW - Substance-Related Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68608469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=Charting+a+course+for+health+services+research+at+the+National+Institute+on+Drug+Abuse.&rft.au=Compton%2C+Wilson+M%3BStein%2C+Jack+B%3BRobertson%2C+Elizabeth+B%3BPintello%2C+Denise%3BPringle%2C+Beverly%3BVolkow%2C+Nora+D&rft.aulast=Compton&rft.aufirst=Wilson&rft.date=2005-10-01&rft.volume=29&rft.issue=3&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=07405472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-22 N1 - Date created - 2005-09-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Clin Exp Hypn. 2002 Apr;50(2):114-48 [11939275] Eval Rev. 2002 Dec;26(6):575-601 [12465571] Qual Saf Health Care. 2003 Feb;12(1):47-52 [12571345] Am J Public Health. 2003 Aug;93(8):1261-7 [12893608] N Engl J Med. 2003 Aug 28;349(9):868-74 [12944573] Health Policy. 2003 Dec;66(3):247-60 [14637010] Prev Sci. 2004 Mar;5(1):31-9 [15058910] Arch Phys Med Rehabil. 2004 Apr;85(4 Suppl 2):S3-12 [15083417] Health Serv Res. 1974 Fall;9(3):208-20 [4436074] J Health Soc Behav. 1995 Mar;36(1):1-10 [7738325] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nephrotic syndrome: an under-recognised immune-mediated complication of non-myeloablative allogeneic haematopoietic cell transplantation. AN - 68607270; 16173966 AB - Nephrotic syndrome (NS) is an extremely rare complication of myeloablative allogeneic haematopoietic cell transplantation (HCT) that usually occurs in association with chronic graft-versus-host disease (C-GVHD). We observed an unexpectedly high incidence of NS in a cohort of 163 consecutive patients undergoing non-myeloablative HCT from a related human leucocyte antigen-compatible donor. Seven patients developed NS at a median 318 d post-transplant (range 119-1203 d; cumulative incidence 6.1%). The median age at onset of NS was 46 years (range 33-59 years); three of the seven patients had no evidence of C-GVHD while four had accompanying limited C-GVHD. At diagnosis, median proteinuria was 16.5 g/24 h (range 3-24 g/24 h). Renal biopsy was performed in four cases and revealed membranous nephropathy. NS was not always associated with other symptoms of C-GVHD, and in contrast to previous reports, usually did not improve with the re-initiation of aggressive immunosuppression, resulting in progressive renal failure necessitating dialysis in three of seven cases. Membranous nephropathy resulting in NS is a previously unrecognised and clinically significant complication of non-myeloablative HCT. JF - British journal of haematology AU - Srinivasan, R AU - Balow, J E AU - Sabnis, S AU - Lundqvist, A AU - Igarashi, T AU - Takahashi, Y AU - Austin, H AU - Tisdale, J AU - Barrett, J AU - Geller, N AU - Childs, R AD - Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, MD 20892-1652, USA. Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 74 EP - 79 VL - 131 IS - 1 SN - 0007-1048, 0007-1048 KW - Immunosuppressive Agents KW - 0 KW - Cyclophosphamide KW - 8N3DW7272P KW - Vidarabine KW - FA2DM6879K KW - fludarabine KW - P2K93U8740 KW - Index Medicus KW - Vidarabine -- analogs & derivatives KW - Humans KW - Aged KW - Kidney Failure, Chronic -- therapy KW - Kidney Failure, Chronic -- etiology KW - Transplantation, Homologous KW - Proteinuria -- etiology KW - Cyclophosphamide -- therapeutic use KW - Adult KW - Graft vs Host Disease KW - Middle Aged KW - Chronic Disease KW - Vidarabine -- therapeutic use KW - Adolescent KW - Time Factors KW - Immunosuppressive Agents -- therapeutic use KW - Kidney Glomerulus -- pathology KW - T-Lymphocytes -- immunology KW - Male KW - Female KW - Hematologic Neoplasms -- therapy KW - Nephrotic Syndrome -- immunology KW - Transplantation Conditioning -- methods KW - Nephrotic Syndrome -- pathology KW - Hematologic Neoplasms -- immunology KW - Hematopoietic Stem Cell Transplantation -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68607270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+haematology&rft.atitle=Nephrotic+syndrome%3A+an+under-recognised+immune-mediated+complication+of+non-myeloablative+allogeneic+haematopoietic+cell+transplantation.&rft.au=Srinivasan%2C+R%3BBalow%2C+J+E%3BSabnis%2C+S%3BLundqvist%2C+A%3BIgarashi%2C+T%3BTakahashi%2C+Y%3BAustin%2C+H%3BTisdale%2C+J%3BBarrett%2C+J%3BGeller%2C+N%3BChilds%2C+R&rft.aulast=Srinivasan&rft.aufirst=R&rft.date=2005-10-01&rft.volume=131&rft.issue=1&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=British+journal+of+haematology&rft.issn=00071048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-15 N1 - Date created - 2005-09-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Br J Haematol. 2007 Mar;136(6):857-9; author reply 859-60 [17341274] Br J Haematol. 2006 Mar;132(6):801-2; author reply 802-3 [16487189] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adverse effects on female development and reproduction in CD-1 mice following neonatal exposure to the phytoestrogen genistein at environmentally relevant doses. AN - 68606288; 15930323 AB - Outbred female CD-1 mice were treated with genistein (Gen), the primary phytoestrogen in soy, by s.c. injections on Neonatal Days 1-5 at doses of 0.5, 5, or 50 mg/kg per day (Gen-0.5, Gen-5, and Gen-50). The day of vaginal opening was observed in mice treated with Gen and compared with controls, and although there were some differences, they were not statistically significant. Gen-treated mice had prolonged estrous cycles with a dose- and age-related increase in severity of abnormal cycles. Females treated with Gen-0.5 or Gen-5 bred to control males at 2, 4, and 6 mo showed statistically significant decreases in the number of live pups over time with increasing dose; at 6 mo, 60% of the females in the Gen-0.5 group and 40% in the Gen-5 group delivered live pups compared with 100% of controls. Mice treated with Gen-50 did not deliver live pups. At 2 mo, >60% of the mice treated with Gen-50 were fertile as determined by uterine implantation sites, but pregnancy was not maintained; pregnancy loss was characterized by fewer, smaller implantation sites and increased reabsorptions. Mice treated with lower doses of Gen had increased numbers of corpora lutea compared with controls, while mice treated with the highest dose had decreased numbers; however, superovulation with eCG/hCG yielded similar numbers of oocytes as controls. Serum levels of progesterone, estradiol, and testosterone were similar between Gen-treated and control mice when measured before puberty and during pregnancy. In summary, neonatal treatment with Gen caused abnormal estrous cycles, altered ovarian function, early reproductive senescence, and subfertility/infertility at environmentally relevant doses. JF - Biology of reproduction AU - Jefferson, Wendy N AU - Padilla-Banks, Elizabeth AU - Newbold, Retha R AD - Developmental Endocrinology Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. jeffers1@niehs.nih.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 798 EP - 806 VL - 73 IS - 4 SN - 0006-3363, 0006-3363 KW - Phytoestrogens KW - 0 KW - Genistein KW - DH2M523P0H KW - Index Medicus KW - Environment KW - Animals KW - Animals, Outbred Strains KW - Embryo Implantation KW - Dose-Response Relationship, Drug KW - Mice KW - Pregnancy KW - Animals, Newborn KW - Litter Size KW - Abortion, Spontaneous KW - Female KW - Male KW - Phytoestrogens -- adverse effects KW - Pregnancy Outcome KW - Ovary -- growth & development KW - Reproduction -- drug effects KW - Genistein -- adverse effects KW - Ovary -- drug effects KW - Ovary -- physiology KW - Estrous Cycle -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68606288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+of+reproduction&rft.atitle=Adverse+effects+on+female+development+and+reproduction+in+CD-1+mice+following+neonatal+exposure+to+the+phytoestrogen+genistein+at+environmentally+relevant+doses.&rft.au=Jefferson%2C+Wendy+N%3BPadilla-Banks%2C+Elizabeth%3BNewbold%2C+Retha+R&rft.aulast=Jefferson&rft.aufirst=Wendy&rft.date=2005-10-01&rft.volume=73&rft.issue=4&rft.spage=798&rft.isbn=&rft.btitle=&rft.title=Biology+of+reproduction&rft.issn=00063363&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-23 N1 - Date created - 2005-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Testosterone suppression of CRH-stimulated cortisol in men. AN - 68603005; 15841103 AB - Despite observations of age-dependent sexual dimorphisms in hypothalamic-pituitary-adrenal (HPA) axis activity, the role of androgens in the regulation of HPA axis activity in men has not been examined. We assessed this role by performing CRH stimulation tests in 10 men (ages 18-45 years) during gonadal suppression with leuprolide acetate and during testosterone addition to leuprolide. CRH-stimulated cortisol levels as well as peak cortisol and greatest cortisol excursion were significantly lower (p<0.05, 0.005, and 0.01, respectively) during testosterone replacement compared with the induced hypogonadal condition (leuprolide plus placebo); cortisol area under the curve was lower at a trend level (p<0.1). Paradoxically, CRH-stimulated corticotropin (ACTH) was increased significantly during testosterone replacement (p<0.05). The cortisol : ACTH ratio, a measure of adrenal sensitivity, was lower during testosterone replacement (p<0.1). A mixed effects regression model showed that testosterone but not estradiol or CBG significantly contributed to the variance of cortisol. These data demonstrate that testosterone regulates CRH-stimulated HPA axis activity in men, with the divergent effects on ACTH and cortisol suggesting a peripheral (adrenal) locus for the suppressive effects on cortisol. Our results further demonstrate that the enhanced stimulated HPA axis activity previously described in young men compared with young women cannot be ascribed to an activational upregulation of the axis by testosterone. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Rubinow, David R AU - Roca, Catherine A AU - Schmidt, Peter J AU - Danaceau, Merry A AU - Putnam, Karen AU - Cizza, Giovanni AU - Chrousos, George AU - Nieman, Lynnette AD - Behavioral Endocrinology Branch, National Institute of Mental Health, Building 10-CRC, 10 Center Drive MSC 1276, Bethesda, MD 20892-1276, USA. rubinowd@mail.nih.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 1906 EP - 1912 VL - 30 IS - 10 SN - 0893-133X, 0893-133X KW - Testosterone KW - 3XMK78S47O KW - Adrenocorticotropic Hormone KW - 9002-60-2 KW - Corticotropin-Releasing Hormone KW - 9015-71-8 KW - Leuprolide KW - EFY6W0M8TG KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Drug Interactions KW - Drug Administration Schedule KW - Testosterone -- pharmacology KW - Double-Blind Method KW - Area Under Curve KW - Humans KW - Adult KW - Radioimmunoassay -- methods KW - Middle Aged KW - Adolescent KW - Time Factors KW - Male KW - Adrenocorticotropic Hormone -- blood KW - Corticotropin-Releasing Hormone -- antagonists & inhibitors KW - Corticotropin-Releasing Hormone -- administration & dosage KW - Leuprolide -- administration & dosage KW - Hydrocortisone -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68603005?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Testosterone+suppression+of+CRH-stimulated+cortisol+in+men.&rft.au=Rubinow%2C+David+R%3BRoca%2C+Catherine+A%3BSchmidt%2C+Peter+J%3BDanaceau%2C+Merry+A%3BPutnam%2C+Karen%3BCizza%2C+Giovanni%3BChrousos%2C+George%3BNieman%2C+Lynnette&rft.aulast=Rubinow&rft.aufirst=David&rft.date=2005-10-01&rft.volume=30&rft.issue=10&rft.spage=1906&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-29 N1 - Date created - 2005-09-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Psychosom Med. 1995 Jan-Feb;57(1):23-31 [7732155] J Endocrinol. 1995 Feb;144(2):311-21 [7706984] J Neurosci. 1996 Mar 1;16(5):1866-76 [8774455] J Neurosci. 1996 Nov 1;16(21):7077-84 [8824343] J Clin Endocrinol Metab. 1996 Oct;81(10):3639-43 [8855815] Am J Physiol. 1998 Oct;275(4 Pt 1):E671-8 [9755087] Neuropsychopharmacology. 1999 May;20(5):434-46 [10192824] Psychosom Med. 1999 Mar-Apr;61(2):154-62 [10204967] J Neurosci. 1999 Aug 1;19(15):6684-93 [10414997] Endocrinol Jpn. 1961 Mar;8:43-9 [13702522] Endocrinology. 1961 May;68:818-24 [13756461] Nature. 1961 Oct 28;192:358-9 [14456548] Endocrinology. 1963 Aug;73:253-60 [14076206] Biol Reprod. 2000 May;62(5):1445-51 [10775199] Neuroimmunomodulation. 2000;8(1):39-44 [10859487] J Neuroendocrinol. 2000 Aug;12(8):784-94 [10929091] Psychoneuroendocrinology. 2001 Apr;26(3):225-40 [11166486] Neuropsychopharmacology. 2001 Dec;25(6):881-91 [11750181] Steroids. 2002 Jul;67(8):721-31 [12117620] Stress. 2002 Dec;5(4):235-47 [12475728] J Clin Endocrinol Metab. 2003 Jul;88(7):3057-63 [12843143] Psychoneuroendocrinology. 2004 Jan;29(1):83-98 [14575731] J Neuroendocrinol. 2004 Mar;16(3):272-8 [15049858] Neurosci Lett. 2004 Jul 15;365(1):43-7 [15234470] Am J Physiol. 1963 Nov;205(5):807-15 [4291060] Endocrinology. 1969 Dec;85(6):1097-102 [4310485] Steroids. 1971 Jul;18(1):91-111 [5107186] J Human Stress. 1978 Jun;4(2):43-8 [659855] Endocrinology. 1979 Sep;105(3):812-7 [223834] Pharmacol Biochem Behav. 1982 Sep;17(3):555-62 [7146052] Neurobiol Aging. 1983 Summer;4(2):133-8 [6685230] J Comp Neurol. 1985 Mar 8;233(2):236-54 [3882778] Psychophysiology. 1987 Mar;24(2):127-31 [3602263] Exp Clin Endocrinol. 1988 Sep;92(1):1-6 [2852600] Clin Endocrinol (Oxf). 1990 Jan;32(1):127-34 [2158868] Res Exp Med (Berl). 1990;190(2):95-103 [2161554] Endocrinology. 1991 Oct;129(4):2166-74 [1915097] Endocrinology. 1991 Nov;129(5):2503-11 [1657578] Steroids. 1992 Jan;57(1):37-43 [1585392] Endocrinology. 1992 Sep;131(3):1261-9 [1324155] Psychosom Med. 1992 Nov-Dec;54(6):648-57 [1454958] J Gerontol. 1993 May;48(3):M72-7 [8387077] J Clin Endocrinol Metab. 1993 Jul;77(1):234-40 [8392084] Health Psychol. 1993 Sep;12(5):420-5 [8223368] Physiol Behav. 1994 Jan;55(1):117-24 [8140154] Neuroendocrinology. 1994 Mar;59(3):228-34 [8159272] Neuroendocrinology. 1994 Aug;60(2):113-23 [7969768] Neurobiol Aging. 1994 Mar-Apr;15(2):227-31 [7838296] Life Sci. 1995;57(9):833-7 [7630311] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cooperating cancer-gene identification through oncogenic-retrovirus-induced insertional mutagenesis. AN - 68596621; 15961513 AB - Multiple cooperating mutations that deregulate different signaling pathways are required to induce cancer. Identifying these cooperating mutations is a prerequisite for developing better combinatorial therapies for treating cancer. Here we show that cooperating cancer mutations can be identified through oncogenic-retrovirus-induced insertional mutagenesis. Among 13 myeloid leukemias induced by transplanting into mice bone marrow cells infected in vitro with a replication-defective retrovirus carrying the Sox4 oncogene, 9 contained insertional mutations at known or suspected cancer genes. This likely occurred because rare bone marrow cells, in which the oncogenic retrovirus happened to integrate and in which it mutated a cooperating cancer gene, were selected because the host harbored a cooperating cancer mutation. Cooperativity between Sox4 and another gene, Mef2c, was subsequently confirmed in transplantation studies, in which deregulated Mef2c expression was shown to accelerate the myeloid leukemia induced by Sox4. Insertional mutagenesis of cooperating cancer genes by a defective oncogenic retrovirus provides a new method for identifying cooperating cancer genes and could aid in the development of better therapies for treating cancer. JF - Blood AU - Du, Yang AU - Spence, Sally E AU - Jenkins, Nancy A AU - Copeland, Neal G AD - Mouse Cancer Genetics Program, National Cancer Institute, Center for Cancer Research, Frederick, MD, USA. Y1 - 2005/10/01/ PY - 2005 DA - 2005 Oct 01 SP - 2498 EP - 2505 VL - 106 IS - 7 SN - 0006-4971, 0006-4971 KW - High Mobility Group Proteins KW - 0 KW - SOXC Transcription Factors KW - Sox4 protein, mouse KW - Trans-Activators KW - Abridged Index Medicus KW - Index Medicus KW - Trans-Activators -- metabolism KW - Animals KW - Blotting, Northern KW - Humans KW - Leukemia, Myeloid -- genetics KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - Polymerase Chain Reaction KW - Bone Marrow Cells -- metabolism KW - Stem Cells -- cytology KW - High Mobility Group Proteins -- genetics KW - Trans-Activators -- genetics KW - Blotting, Southern KW - Models, Genetic KW - Genetic Vectors KW - Mice, Inbred C57BL KW - Genetic Therapy -- methods KW - Bone Marrow Cells -- cytology KW - Cell Transplantation KW - Time Factors KW - Mutation KW - High Mobility Group Proteins -- metabolism KW - Bone Marrow Transplantation KW - Genetic Techniques KW - Retroviridae -- genetics KW - Neoplasms -- genetics KW - Mutagenesis, Insertional KW - Oncogenic Viruses -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68596621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Cooperating+cancer-gene+identification+through+oncogenic-retrovirus-induced+insertional+mutagenesis.&rft.au=Du%2C+Yang%3BSpence%2C+Sally+E%3BJenkins%2C+Nancy+A%3BCopeland%2C+Neal+G&rft.aulast=Du&rft.aufirst=Yang&rft.date=2005-10-01&rft.volume=106&rft.issue=7&rft.spage=2498&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-28 N1 - Date created - 2005-09-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Genet. 1999 Nov;23(3):348-53 [10610183] Blood. 2005 Jun 1;105(11):4235-46 [15713797] Hum Mol Genet. 2000 Sep 22;9(15):2297-304 [11001933] Cancer Res. 2000 Nov 15;60(22):6303-6 [11103788] Genesis. 2001 Jun;30(2):82-8 [11416868] Trends Biochem Sci. 2002 Jan;27(1):40-7 [11796223] Nat Cell Biol. 2002 Jul;4(7):540-4 [12080349] J Neurooncol. 2002 May;57(3):201-14 [12125983] Blood. 2002 Aug 1;100(3):998-1007 [12130514] Dev Cell. 2002 Aug;3(2):167-70 [12194848] Nat Genet. 2002 Sep;32(1):166-74 [12185365] Am J Pathol. 2002 Oct;161(4):1315-23 [12368205] Nucleic Acids Res. 2003 Jan 1;31(1):51-4 [12519945] J Virol. 2003 Feb;77(3):2056-62 [12525640] N Engl J Med. 2003 Jan 16;348(3):255-6 [12529469] Gene. 2003 Mar 13;306:1-12 [12657462] Adv Cancer Res. 2003;88:53-99 [12665053] Nat Immunol. 2003 Jun;4(6):525-32 [12717432] Science. 2003 Oct 17;302(5644):415-9 [14564000] Science. 2004 Jan 16;303(5656):333 [14726584] Oncogene. 2004 Apr 22;23(19):3444-53 [15064731] Nat Genet. 2004 Jun;36(6):624-30 [15146183] Cancer Sci. 2004 Jun;95(6):503-7 [15182431] Cytogenet Genome Res. 2004;105(2-4):442-7 [15237232] Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11334-7 [15273287] Oncogene. 1989 Jun;4(6):789-94 [2734021] Nature. 1994 Feb 17;367(6464):645-8 [7509044] Nat Genet. 1996 Feb;12(2):149-53 [8563752] Nature. 1996 Apr 25;380(6576):711-4 [8614465] Eur J Immunol. 1997 May;27(5):1292-5 [9174623] Cancer Res. 1998 Jan 15;58(2):198-203 [9443391] Nat Genet. 1999 Oct;23(2):166-75 [10508512] Blood. 2004 Dec 1;104(12):3437-44 [15304397] Cancer Res. 2005 Jan 1;65(1):166-76 [15665292] Cell. 2000 Jan 7;100(1):57-70 [10647931] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells. AN - 68596253; 15933056 AB - Recent reports linking insertional activation of LMO2 following gene therapy for X-linked severe combined immunodeficiency (X-SCID) have led to a re-evaluation of risks following gene therapy with retroviral vectors. In our analysis of 702 integration sites in rhesus macaques that underwent transplantation up to 7 years earlier with autologous CD34+ cells transduced with amphotropic murine leukemia virus (MLV)-derived retroviral vectors containing marker genes, we detected insertion into one locus, the Mds1/Evi1 region, a total of 14 times in 9 animals. Mds1/Evi1 integrations were observed stably long term, primarily in myeloid cells. We hypothesize that this over-representation likely results from an impact on the self-renewal and engraftment potential of CD34+ progenitor cells via insertional mutagenesis at this specific locus. There is no evidence of ongoing in vivo clonal expansion of the Mds1/Evi1 populations, and all animals are hematologically normal without evidence for leukemia. Characterization of integration sites in this relevant preclinical model provides critical information for gene therapy risk assessment as well as identification of genes controlling hematopoiesis. JF - Blood AU - Calmels, Boris AU - Ferguson, Cole AU - Laukkanen, Mikko O AU - Adler, Rima AU - Faulhaber, Marion AU - Kim, Hyeoung-Joon AU - Sellers, Stephanie AU - Hematti, Peiman AU - Schmidt, Manfred AU - von Kalle, Christof AU - Akagi, Keiko AU - Donahue, Robert E AU - Dunbar, Cynthia E AD - Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA. Y1 - 2005/10/01/ PY - 2005 DA - 2005 Oct 01 SP - 2530 EP - 2533 VL - 106 IS - 7 SN - 0006-4971, 0006-4971 KW - Antigens, CD34 KW - 0 KW - DNA-Binding Proteins KW - MECOM protein, human KW - Transcription Factors KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Leukemia Virus, Murine -- genetics KW - Humans KW - Antigens, CD34 -- biosynthesis KW - Disease Progression KW - Primates KW - Hematopoiesis KW - Leukemia -- genetics KW - Risk KW - Genetic Vectors KW - Genetic Therapy -- methods KW - Macaca mulatta KW - Stem Cells KW - Time Factors KW - Mutagenesis, Insertional KW - Leukocytes, Mononuclear -- cytology KW - Granulocytes -- cytology KW - Proto-Oncogenes -- genetics KW - DNA-Binding Proteins -- genetics KW - Retroviridae -- genetics KW - Hematopoietic Stem Cells -- metabolism KW - Transcription Factors -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68596253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Recurrent+retroviral+vector+integration+at+the+Mds1%2FEvi1+locus+in+nonhuman+primate+hematopoietic+cells.&rft.au=Calmels%2C+Boris%3BFerguson%2C+Cole%3BLaukkanen%2C+Mikko+O%3BAdler%2C+Rima%3BFaulhaber%2C+Marion%3BKim%2C+Hyeoung-Joon%3BSellers%2C+Stephanie%3BHematti%2C+Peiman%3BSchmidt%2C+Manfred%3Bvon+Kalle%2C+Christof%3BAkagi%2C+Keiko%3BDonahue%2C+Robert+E%3BDunbar%2C+Cynthia+E&rft.aulast=Calmels&rft.aufirst=Boris&rft.date=2005-10-01&rft.volume=106&rft.issue=7&rft.spage=2530&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-28 N1 - Date created - 2005-09-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Histol Histopathol. 2000 Jan;15(1):109-17 [10668202] Blood. 2005 Dec 1;106(12):3932-9 [16109773] Mol Ther. 2000 Mar;1(3):285-93 [10933944] Hum Gene Ther. 2001 Apr 10;12(6):607-17 [11426461] J Clin Invest. 2001 Aug;108(3):447-55 [11489938] Br J Haematol. 2001 Sep;114(3):566-73 [11552981] Science. 2002 Apr 19;296(5567):497 [11964471] Nat Genet. 2002 Sep;32(1):166-74 [12185365] Blood. 2002 Oct 15;100(8):2737-43 [12351380] Blood. 2003 Feb 1;101(3):837-45 [12393383] Blood. 2003 Mar 15;101(6):2199-205 [12424191] Blood. 2003 Mar 15;101(6):2099-114 [12511419] Blood Cells Mol Dis. 2003 Sep-Oct;31(2):206-12 [12972028] Science. 2003 Oct 17;302(5644):415-9 [14564000] Nucleic Acids Res. 2004 Jan 1;32(Database issue):D523-7 [14681473] Mol Ther. 2004 Jan;9(1):5-13 [14741772] J Gene Med. 2004 Apr;6(4):367-73 [15079811] Exp Hematol. 2004 Feb;32(2):163-70 [15102477] J Clin Invest. 2004 Sep;114(5):713-9 [15343390] Nat Med. 1996 Feb;2(2):190-7 [8574964] PLoS Biol. 2004 Dec;2(12):e423 [15550989] Blood. 2000 Jul 1;96(1):1-8 [10891424] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Carbohydrate engineering of the recognition motifs in streptococcal co-aggregation receptor polysaccharides. AN - 68589364; 16164562 AB - The cell wall polysaccharides of certain oral streptococci function as receptors for the lectin-like surface adhesins on other members of the oral biofilm community. Recognition of these receptor polysaccharides (RPS) depends on the presence of a host-like motif, either GalNAcbeta1-3Gal (Gn) or Galbeta1-3GalNAc (G), within the oligosaccharide repeating units of different RPS structural types. Type 2Gn RPS of Streptococcus gordonii 38 and type 2G RPS of Streptococcus oralis J22 are composed of heptasaccharide repeats that are identical except for their host-like motifs. In the current investigation, the genes for the glycosyltransferases that synthesize these motifs were identified by high-resolution nuclear magnetic resonance (NMR) analysis of genetically altered polysaccharides. RPS production was switched from type 2Gn to 2G by replacing wefC and wefD in the type 2Gn gene cluster of S. gordonii 38 with wefF and wefG from the type 2G cluster of S. oralis J22. Disruption of either wefC or wefF abolished cell surface RPS production. In contrast, disruption of wefD in the type 2Gn cluster or wefG in the type 2G cluster eliminated beta-GalNAc from the Gn motif or beta-Gal from the G motif, resulting in mutant polysaccharides with hexa- rather than heptasaccharide subunits. The mutant polysaccharides reacted like wild-type RPS with rabbit antibodies against type 2Gn or 2G RPS but were inactive as co-aggregation receptors. Additional mutant polysaccharides with GalNAcbeta1-3GalNAc or Galbeta1-3Gal recognition motifs were engineered by replacing wefC in the type 2Gn cluster with wefF or wefF in the type 2G cluster with wefC respectively. The reactions of these genetically modified polysaccharides as antigens and receptors provide further insight into the structural basis of RPS function. JF - Molecular microbiology AU - Yoshida, Yasuo AU - Ganguly, Soumya AU - Bush, C Allen AU - Cisar, John O AD - Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 244 EP - 256 VL - 58 IS - 1 SN - 0950-382X, 0950-382X KW - DNA, Bacterial KW - 0 KW - Polysaccharides, Bacterial KW - Receptors, Cell Surface KW - Glycosyltransferases KW - EC 2.4.- KW - Index Medicus KW - Genes, Bacterial KW - Genetic Engineering KW - Cell Wall -- chemistry KW - Glycosyltransferases -- genetics KW - Sequence Analysis, DNA KW - Receptors, Cell Surface -- chemistry KW - Gene Deletion KW - Magnetic Resonance Spectroscopy KW - Bacterial Adhesion -- genetics KW - Amino Acid Motifs KW - Recombination, Genetic KW - Carbohydrate Sequence KW - Molecular Sequence Data KW - Receptors, Cell Surface -- genetics KW - Mutagenesis, Insertional KW - Streptococcus -- genetics KW - Polysaccharides, Bacterial -- chemistry KW - Polysaccharides, Bacterial -- metabolism KW - Streptococcus -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68589364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+microbiology&rft.atitle=Carbohydrate+engineering+of+the+recognition+motifs+in+streptococcal+co-aggregation+receptor+polysaccharides.&rft.au=Yoshida%2C+Yasuo%3BGanguly%2C+Soumya%3BBush%2C+C+Allen%3BCisar%2C+John+O&rft.aulast=Yoshida&rft.aufirst=Yasuo&rft.date=2005-10-01&rft.volume=58&rft.issue=1&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=Molecular+microbiology&rft.issn=0950382X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-13 N1 - Date created - 2005-09-16 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - AB181235; GENBANK N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adverse events among patients in a behavioral treatment trial for heroin and cocaine dependence: effects of age, race, and gender. AN - 68579258; 16157230 AB - Safety monitoring is a critical element of clinical trials evaluating treatment for substance dependence, but is complicated by participants' high levels of medical and psychiatric comorbidity. This paper describes AEs reported in a large (N = 286), 29-week outpatient study of behavioral interventions for heroin and cocaine dependence in methadone-maintained outpatients. A total of 884 AEs were reported (3.1 per patient, 0.12 per patient-week), the most common being infections (26.8%), gastrointestinal (20.5%), musculoskeletal (12.3%), and general (10%) disorders. Serious AEs were uncommon (1.6% of total). Female participants reported significantly higher rates of AEs (incidence density ratio, IDR = 1.38, p < 0.0001); lower rates of AEs were reported by African Americans (IDR = 0.73, p<0.0001) and participants over age 40 reported lower rates of AEs (IDR = 0.84, p = 0.0095). AE incidence was not associated with the study intervention or with psychiatric comorbidity. Further work is needed to adapt AE coding systems for behavioral trials for substance dependence; the standard Medical Dictionary for Regulatory Activities, International Federation of Pharmaceutical Manufacturers Associations (MedDRA) coding system used in this report did not contain a separate category for one of the most common types of AE, dental problems. Nonetheless, the data reported here should help provide a context in which investigators and IRBs can interpret the patterns of AEs they encounter. JF - Drug and alcohol dependence AU - Schroeder, Jennifer R AU - Schmittner, John P AU - Epstein, David H AU - Preston, Kenzie L AD - Intramural Research Program, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. jschroed@intra.nida.nih.gov Y1 - 2005/10/01/ PY - 2005 DA - 2005 Oct 01 SP - 45 EP - 51 VL - 80 IS - 1 SN - 0376-8716, 0376-8716 KW - Narcotics KW - 0 KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Administration, Oral KW - Motivation KW - Combined Modality Therapy KW - Humans KW - Narcotics -- administration & dosage KW - Methadone -- administration & dosage KW - Counseling KW - Comorbidity KW - Ambulatory Care KW - Psychotherapy, Group KW - Risk Factors KW - Adult KW - Incidence KW - Middle Aged KW - Female KW - Male KW - Heroin Dependence -- ethnology KW - Heroin Dependence -- epidemiology KW - Cognitive Therapy KW - Cocaine-Related Disorders -- ethnology KW - Health Status KW - European Continental Ancestry Group -- psychology KW - Heroin Dependence -- rehabilitation KW - European Continental Ancestry Group -- statistics & numerical data KW - Cocaine-Related Disorders -- epidemiology KW - African Continental Ancestry Group -- psychology KW - Cocaine-Related Disorders -- rehabilitation KW - African Continental Ancestry Group -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68579258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Adverse+events+among+patients+in+a+behavioral+treatment+trial+for+heroin+and+cocaine+dependence%3A+effects+of+age%2C+race%2C+and+gender.&rft.au=Schroeder%2C+Jennifer+R%3BSchmittner%2C+John+P%3BEpstein%2C+David+H%3BPreston%2C+Kenzie+L&rft.aulast=Schroeder&rft.aufirst=Jennifer&rft.date=2005-10-01&rft.volume=80&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-27 N1 - Date created - 2005-09-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Advances in pediatric asthma and atopic dermatitis. AN - 68572752; 16160544 AB - Allergic diseases, including asthma, allergic rhinitis, atopic dermatitis, food allergy, and urticaria are common in general pediatric practice. This review highlights several significant advances in pediatric allergy over the past year, focusing on asthma and atopic dermatitis. With increasing options for the treatment of allergic diseases, much work is now focused on methods for individualizing treatments to a patient's phenotype and genotype. Progress over the past year includes the characterization of effects of regular albuterol use in patients with genetic variations in the beta-adrenergic receptor. Maintenance asthma regimens for children in the first years of life are also an ongoing focus. The relation between upper airway allergic inflammation and asthma has continued to accumulate support and now extends to the middle ear. Environmental influences on asthma and interventions have been described, including environmental controls for asthma and the role of air pollution on lung development in children. Finally, concerns have been raised regarding the use of topical immunomodulators in young children with atopic dermatitis. Progress continues in the care of children with atopic diseases. Attention to treatment with appropriate medications, patient-individualized environmental controls, and extensive education are the keys to successfully treating atopic children. This review highlights several recent advances but is not intended to be a comprehensive review. JF - Current opinion in pediatrics AU - Foroughi, Shabnam AU - Thyagarajan, Ananth AU - Stone, Kelly D AD - Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 658 EP - 663 VL - 17 IS - 5 SN - 1040-8703, 1040-8703 KW - Bronchodilator Agents KW - 0 KW - Calcineurin Inhibitors KW - Dermatologic Agents KW - Albuterol KW - QF8SVZ843E KW - Index Medicus KW - Albuterol -- administration & dosage KW - Nebulizers and Vaporizers KW - Humans KW - Bronchodilator Agents -- administration & dosage KW - Lymphoma -- chemically induced KW - Child KW - Dermatologic Agents -- adverse effects KW - Dermatitis, Atopic -- therapy KW - Asthma -- genetics KW - Asthma -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68572752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+pediatrics&rft.atitle=Advances+in+pediatric+asthma+and+atopic+dermatitis.&rft.au=Foroughi%2C+Shabnam%3BThyagarajan%2C+Ananth%3BStone%2C+Kelly+D&rft.aulast=Foroughi&rft.aufirst=Shabnam&rft.date=2005-10-01&rft.volume=17&rft.issue=5&rft.spage=658&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+pediatrics&rft.issn=10408703&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-14 N1 - Date created - 2005-09-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Occupation, hobbies, and acute leukemia in adults. AN - 68504568; 16111530 AB - Occupational and industrial exposures have been implicated in the etiology of leukemia, yet uncertainty remains regarding potential high risk occupations. We examined the associations between self-reported occupations and hobbies and acute leukemia risk using data from 811 cases and 637 controls participating in a case-control study in the U.S. and Canada. We found that several occupations may increase the risk of acute leukemia, particularly occupations related to petroleum products, rubber, nuclear energy, munitions, plastics, and electronics manufacturing. Differences were noted according to histological type. Other occupations and hobbies were not clearly associated with risk. JF - Leukemia research AU - Terry, Paul D AU - Shore, David L AU - Rauscher, Garth H AU - Sandler, Dale P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, Research, Triangle Park, NC 27709, USA. pdterry@sph.emory.edu Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 1117 EP - 1130 VL - 29 IS - 10 SN - 0145-2126, 0145-2126 KW - Index Medicus KW - Canada -- epidemiology KW - Acute Disease KW - Odds Ratio KW - Risk Factors KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Female KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- epidemiology KW - Occupational Exposure KW - Leukemia, Myeloid -- epidemiology KW - Hobbies KW - Leukemia, Myeloid -- etiology KW - Occupations KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68504568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia+research&rft.atitle=Occupation%2C+hobbies%2C+and+acute+leukemia+in+adults.&rft.au=Terry%2C+Paul+D%3BShore%2C+David+L%3BRauscher%2C+Garth+H%3BSandler%2C+Dale+P&rft.aulast=Terry&rft.aufirst=Paul&rft.date=2005-10-01&rft.volume=29&rft.issue=10&rft.spage=1117&rft.isbn=&rft.btitle=&rft.title=Leukemia+research&rft.issn=01452126&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-10-18 N1 - Date created - 2005-08-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Leuk Res. 2005 Oct;29(10):1105-6 [15913775] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interactive role of the toll-like receptor 4 and reactive oxygen species in LPS-induced microglia activation. AN - 68501361; 15920727 AB - Microglia are activated by lipopolysaccharide (LPS) to produce neurotoxic pro-inflammatory factors and reactive oxygen species (ROS). While a multitude of LPS receptors and corresponding pathways have been identified, the detailed mechanisms mediating the microglial response to LPS are unclear. Using mice lacking a functional toll-like receptor 4 (TLR4), we demonstrate that TLR4 and ROS work in concert to mediate microglia activation, where the contribution from each pathway is dependent on the concentration of LPS. Immunocytochemical staining of microglia in neuron-glia cultures with antibodies against F4/80 revealed that while TLR4(+/+) microglia were activated the low concentration of 1 ng/ml of LPS, TLR4(-/-) microglia exhibit activated morphology in response to LPS only at higher concentrations (100-1,000 ng/ml). Additionally, tumor necrosis factor-alpha (TNF-alpha) was only produced from higher concentrations (100-1,000 ng/ml) of LPS in TLR4(-/-) enriched microglia cultures. Diphenylene iodonium (DPI), an inhibitor of NADPH oxidase, reduced TNF-alpha production from TLR4(-/-) microglia. The influence of TLR4 on LPS-induced superoxide production was tested in rat enriched microglia cultures, where the presence or absence of serum failed to show any effect on the superoxide production. Further, both TLR4(-/-) and TLR4(+/+) microglia showed a similar increase in extracellular superoxide production when exposed to LPS (1-1,000 ng/ml). These data indicate that LPS-induced superoxide production in microglia is independent of TLR4 and that ROS derived from the production of extracellular superoxide in microglia mediates the LPS-induced TNF-alpha response of both the TLR4-dependent and independent pathway. (c) 2005 Wiley-Liss, Inc. JF - Glia AU - Qin, Liya AU - Li, Guorong AU - Qian, Xun AU - Liu, Yuxin AU - Wu, Xuefei AU - Liu, Bin AU - Hong, Jau-Shyong AU - Block, Michelle L AD - Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 78 EP - 84 VL - 52 IS - 1 SN - 0894-1491, 0894-1491 KW - Enzyme Inhibitors KW - 0 KW - Inflammation Mediators KW - Lipopolysaccharides KW - Reactive Oxygen Species KW - Tlr4 protein, mouse KW - Toll-Like Receptor 4 KW - Tumor Necrosis Factor-alpha KW - Superoxides KW - 11062-77-4 KW - NADPH Oxidase KW - EC 1.6.3.1 KW - Index Medicus KW - Neurodegenerative Diseases -- physiopathology KW - Animals KW - Coculture Techniques KW - Dose-Response Relationship, Drug KW - Lipopolysaccharides -- pharmacology KW - Mice KW - Mice, Knockout KW - Rats KW - Animals, Newborn KW - Superoxides -- metabolism KW - Rats, Inbred F344 KW - Oxidative Stress -- physiology KW - Cells, Cultured KW - Neurodegenerative Diseases -- metabolism KW - Oxidative Stress -- drug effects KW - Inflammation Mediators -- pharmacology KW - Mice, Inbred C3H KW - Mice, Inbred C57BL KW - Enzyme Inhibitors -- pharmacology KW - Tumor Necrosis Factor-alpha -- metabolism KW - Female KW - NADPH Oxidase -- metabolism KW - Reactive Oxygen Species -- metabolism KW - Gliosis -- metabolism KW - Gliosis -- physiopathology KW - Encephalitis -- physiopathology KW - NADPH Oxidase -- antagonists & inhibitors KW - Toll-Like Receptor 4 -- genetics KW - Gliosis -- genetics KW - Encephalitis -- chemically induced KW - Encephalitis -- genetics KW - Gliosis -- chemically induced KW - Encephalitis -- metabolism KW - Microglia -- drug effects KW - Microglia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68501361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Glia&rft.atitle=Interactive+role+of+the+toll-like+receptor+4+and+reactive+oxygen+species+in+LPS-induced+microglia+activation.&rft.au=Qin%2C+Liya%3BLi%2C+Guorong%3BQian%2C+Xun%3BLiu%2C+Yuxin%3BWu%2C+Xuefei%3BLiu%2C+Bin%3BHong%2C+Jau-Shyong%3BBlock%2C+Michelle+L&rft.aulast=Qin&rft.aufirst=Liya&rft.date=2005-10-01&rft.volume=52&rft.issue=1&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=Glia&rft.issn=08941491&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-09 N1 - Date created - 2005-08-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Expression pattern of four membrane-type matrix metalloproteinases in the normal and diseased mouse mammary gland. AN - 68436278; 15895410 AB - Both mammary gland development and mammary carcinogenesis involve extensive remodeling of the mammary gland extracellular matrix. The expression of four membrane-type matrix metalloproteinases (MT-MMPs) with matrix remodeling potential in development and tumorigenesis was evaluated by in-situ hybridization on mouse mammary gland sections. MT1-MMP and MT3-MMP were found in the mammary stroma mainly around epithelial structures in both developing and mature mammary gland. In contrast, MT2-MMP was found exclusively in the mammary epithelium. Lactating gland expressed none of the examined MT-MMPs. Mammary gland tumors expressed MT1-MMP, MT2-MMP, and MT3-MMP while MT4-MMP was not expressed in any developmental or cancerous stage analyzed here. Our results suggest that MT1-MMP, MT2-MMP, and MT3-MMP may be involved in remodeling of both the normal and diseased mammary gland either directly or indirectly by activation of other MMPs. JF - Journal of cellular physiology AU - Szabova, Ludmila AU - Yamada, Susan S AU - Birkedal-Hansen, Henning AU - Holmbeck, Kenn AD - Craniofacial and Skeletal Diseases Branch, Matrix Metalloproteinase Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 123 EP - 132 VL - 205 IS - 1 SN - 0021-9541, 0021-9541 KW - Mmp14 protein, mouse KW - 0 KW - Mmp15 protein, mouse KW - Mmp16 protein, mouse KW - Matrix Metalloproteinase 15 KW - EC 3.4.24.- KW - Matrix Metalloproteinase 16 KW - Matrix Metalloproteinases, Membrane-Associated KW - Metalloendopeptidases KW - Matrix Metalloproteinase 14 KW - EC 3.4.24.80 KW - Index Medicus KW - Aging -- physiology KW - Animals KW - Lactation -- genetics KW - Lactation -- metabolism KW - Mice KW - Health KW - Female KW - Pregnancy KW - Gene Expression Profiling KW - Gene Expression Regulation, Enzymologic -- genetics KW - Mammary Neoplasms, Animal -- pathology KW - Mammary Glands, Animal -- cytology KW - Mammary Neoplasms, Animal -- genetics KW - Mammary Glands, Animal -- pathology KW - Mammary Neoplasms, Animal -- enzymology KW - Mammary Glands, Animal -- enzymology KW - Metalloendopeptidases -- metabolism KW - Metalloendopeptidases -- genetics KW - Metalloendopeptidases -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68436278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+physiology&rft.atitle=Expression+pattern+of+four+membrane-type+matrix+metalloproteinases+in+the+normal+and+diseased+mouse+mammary+gland.&rft.au=Szabova%2C+Ludmila%3BYamada%2C+Susan+S%3BBirkedal-Hansen%2C+Henning%3BHolmbeck%2C+Kenn&rft.aulast=Szabova&rft.aufirst=Ludmila&rft.date=2005-10-01&rft.volume=205&rft.issue=1&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+physiology&rft.issn=00219541&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-04 N1 - Date created - 2005-08-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comorbidity between DSM-IV Alcohol and Specific Drug Use Disorders in the United States: Results from the National Epidemiologic Survey on Alcohol and Related Conditions AN - 57082474; 200600826 AB - Background: To date, there have been no published data on 12-month comorbidity of DSM-IV alcohol and drug use disorders in the general U.S. population. The purposes of the present study were to examine the prevalence and comorbidity of alcohol and specific drug use disorders, and to identify sociodemographic and psychopathologic correlates and treatment seeking among three groups of respondents: (1) those with alcohol use disorders only; (2) those with drug use disorders only; (3) those with comorbid alcohol and drug use disorders. Methods: Information on 12-month alcohol and specific drug use disorders in the United States was derived from face-to-face interviews in the National Institute on Alcohol Abuse and Alcoholism's (NIAAA) 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC: n = 43,093). Results: Prevalences were 7.35% for alcohol use disorders only, 0.90% for drug use disorder only and 1.10% for comorbid alcohol and drug use disorders. Sociodemographic and psychopathologic correlates of these three groups were quite different, with the drug use disorder and comorbid groups significantly more likely to be young, male, never married and of lower socioeconomic status than the alcohol use disorder only group. Associations between current alcohol use disorders and 25 specific drug use disorders were generally positive and statistically significant. The 12-month prevalence of treatment seeking significantly increased from 6.06% for those with an alcohol use disorder only to 15.63% for those with a drug use disorder only, and to 21.76% for those with comorbid alcohol and drug use disorders. Conclusions: This study provides detailed data on the homotypic comorbidity of alcohol use disorders and 25 different drug use disorders and confirms the high levels of association seen in previous studies based on lifetime measures. Implications of this study are discussed in terms of integrating alcohol and drug treatment services and refining prevention and intervention efforts. Tables, References. [Copyright 2005 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Stinson, Frederick S AU - Grant, Bridget F AU - Dawson, Deborah A AU - Ruan, W June AU - Huang, Boji AU - Saha, Tulshi AD - Laboratory Epidemiology & Biometry, Division Intramural Clinical & Biological Research, National Instit Alco fstinson@mail.nih.gov Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 105 EP - 116 VL - 80 IS - 1 SN - 0376-8716, 0376-8716 KW - DSM-IV alcohol abuse KW - DSM-IV alcohol dependence KW - Epidemiology KW - Comorbidity KW - Socioeconomic factors KW - Diagnostic and Statistical Manual IV KW - Alcohol abuse KW - Alcohol dependence KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57082474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Comorbidity+between+DSM-IV+Alcohol+and+Specific+Drug+Use+Disorders+in+the+United+States%3A+Results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions&rft.au=Stinson%2C+Frederick+S%3BGrant%2C+Bridget+F%3BDawson%2C+Deborah+A%3BRuan%2C+W+June%3BHuang%2C+Boji%3BSaha%2C+Tulshi&rft.aulast=Stinson&rft.aufirst=Frederick&rft.date=2005-10-01&rft.volume=80&rft.issue=1&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2005.03.009 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-04-07 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Alcohol abuse; Alcohol dependence; Diagnostic and Statistical Manual IV; Socioeconomic factors; Epidemiology; Comorbidity DO - http://dx.doi.org/10.1016/j.drugalcdep.2005.03.009 ER - TY - JOUR T1 - Co-Occurring DSM-IV Drug Abuse in DSM-IV Drug Dependence: Results from the National Epidemiologic Survey on Alcohol and Related Conditions AN - 57081008; 200600358 AB - The extent to which dependence occurs with or without abuse is important because of the potential for underestimation and biased estimates of drug dependence in surveys that rely on abuse as a screening method for dependence. The purpose of this paper was to present the prevalence of DSM-IV drug dependence with and without drug abuse in a nationally representative sample, as well as in subgroups defined by sex, age and race/ethnicity. Among all respondents with current drug dependence, 22.0% did not additionally meet criteria for abuse (19.5% among males and 27.8% among females). Current drug dependence without abuse was especially common among females age 45-64 (52.6% of all cases). Among those with lifetime diagnoses of drug dependence, a small proportion overall, 5.0% had no symptoms of abuse, with the highest proportion again found among females aged 45-64 (19.5% of all cases). The use of drug abuse as a screening method for drug dependence in large epidemiologic studies will differentially underestimate the prevalence of dependence by subgroup, affecting many types of research. Dependence with and without abuse may represent heterogeneous phenotypes for genetic and gene-environment research, which should be explored. Tables, References. [Copyright 2005 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Hasin, Deborah S AU - Hatzenbueler, Mark AU - Smith, Sharon AU - Grant, Bridget F AD - Laboratory Epidemiology & Biometry, Division Clinical & Biological Intramural Research, National Instit Alco Y1 - 2005/10// PY - 2005 DA - October 2005 SP - 117 EP - 123 VL - 80 IS - 1 SN - 0376-8716, 0376-8716 KW - Alcohol abuse KW - Drug abuse KW - Alcohol dependence KW - Drug dependence KW - Epidemiology KW - Drug dependency KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57081008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Co-Occurring+DSM-IV+Drug+Abuse+in+DSM-IV+Drug+Dependence%3A+Results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions&rft.au=Hasin%2C+Deborah+S%3BHatzenbueler%2C+Mark%3BSmith%2C+Sharon%3BGrant%2C+Bridget+F&rft.aulast=Hasin&rft.aufirst=Deborah&rft.date=2005-10-01&rft.volume=80&rft.issue=1&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2005.03.010 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-04-07 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Alcohol abuse; Drug abuse; Alcohol dependence; Epidemiology; Drug dependency DO - http://dx.doi.org/10.1016/j.drugalcdep.2005.03.010 ER - TY - JOUR T1 - Hypnotic disgust makes moral judgments more severe AN - 37718111; 3264474 AB - Highly hypnotizable participants were given a posthypnotic suggestion to feel a flash of disgust whenever they read an arbitrary word. They were then asked to rate moral transgressions described in vignettes that either did or did not include the disgust-inducing word. Two studies show that moral judgments can be made more severe by the presence of a flash of disgust. These findings suggest that moral judgments may be grounded in affectively laden moral intuitions. Reprinted by permission of Sage Publications JF - Psychological science AU - Wheatley, Thalia AU - Haidt, Jonathan AD - National Institutes of Health ; University of Virginia Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 780 EP - 784 VL - 16 IS - 10 SN - 0956-7976, 0956-7976 KW - Sociology KW - Morals KW - Sight KW - Psychology KW - Regression analysis KW - Empirical research KW - Judgement UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37718111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+science&rft.atitle=Hypnotic+disgust+makes+moral+judgments+more+severe&rft.au=Wheatley%2C+Thalia%3BHaidt%2C+Jonathan&rft.aulast=Wheatley&rft.aufirst=Thalia&rft.date=2005-10-01&rft.volume=16&rft.issue=10&rft.spage=780&rft.isbn=&rft.btitle=&rft.title=Psychological+science&rft.issn=09567976&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 10404; 8282 8281 6085; 7007 3322 6071 1542 11325 4551; 4200 10902; 10739 12228 10919; 11650 11505 1678 ER - TY - JOUR T1 - A new tool to assess treatment fidelity and evaluation of treatment fidelity across 10 years of health behavior research AN - 36494664; 3305211 AB - A. Bellg, B. Borrelli, et al. (2004) previously developed a framework that consisted of strategies to enhance treatment fidelity of health behavior interventions. The present study used this framework to (a) develop a measure of treatment fidelity and (b) use the measure to evaluate treatment fidelity in articles published in 5 journals over 10 years. Three hundred forty-two articles met inclusion criteria: 22% reported strategies to maintain provider skills, 27% reported checking adherence to protocol, 35% reported using a treatment manual. 54% reported using none of these strategies, and 12% reported using all 3 strategies. The mean proportion adherence to treatment fidelity strategies was 55; 15.5% of articles achieved greater than or equal to .80. This tool may be useful for researchers, grant reviewers, and editors planning and evaluating trials. Reprinted by permission of the American Psychological Association JF - Journal of consulting and clinical psychology AU - Borrelli, Belinda AU - Sepinwall, Deborah AU - Ernst, Denise AU - Bellg, Albert J AU - Czajkowski, Susan AU - Breger, Rosemary AU - DeFrancesco, Carol AU - Levesque, Chantal AU - Sharp, Daryl L AU - Ogedegbe, Gbenga AU - Resnick, Barbara AU - Orwig, Denise AD - Brown University ; University of New Mexico ; Appleton Heart Institute ; National Institutes of Health ; University of Oregon ; Southwest Missouri State University ; University of Rochester ; Columbia University ; University of Maryland Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 852 EP - 860 VL - 73 IS - 5 SN - 0022-006X, 0022-006X KW - Sociology KW - Evaluation KW - Conceptualization KW - Medical treatment KW - Clinical psychology KW - Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36494664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+consulting+and+clinical+psychology&rft.atitle=A+new+tool+to+assess+treatment+fidelity+and+evaluation+of+treatment+fidelity+across+10+years+of+health+behavior+research&rft.au=Borrelli%2C+Belinda%3BSepinwall%2C+Deborah%3BErnst%2C+Denise%3BBellg%2C+Albert+J%3BCzajkowski%2C+Susan%3BBreger%2C+Rosemary%3BDeFrancesco%2C+Carol%3BLevesque%2C+Chantal%3BSharp%2C+Daryl+L%3BOgedegbe%2C+Gbenga%3BResnick%2C+Barbara%3BOrwig%2C+Denise&rft.aulast=Borrelli&rft.aufirst=Belinda&rft.date=2005-10-01&rft.volume=73&rft.issue=5&rft.spage=852&rft.isbn=&rft.btitle=&rft.title=Journal+of+consulting+and+clinical+psychology&rft.issn=0022006X&rft_id=info:doi/10.1037%2F0022-006X.73.5.852 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4551; 7994; 7890 5792 10484; 2688 2449 10404; 2388 10404 DO - http://dx.doi.org/10.1037/0022-006X.73.5.852 ER - TY - JOUR T1 - Epidemiology of HIV/AIDS among Asians and Pacific islanders in the United States AN - 36440010; 3331506 AB - Although the percentage of overall AIDS diagnoses remains low among Asian and Pacific Islanders (APIs) in the United States compared with other racial/ethnic groups, research on API risk behaviors and health status suggest that the low number of AIDS cases may not provide a full picture of the epidemic and issues faced by this understudied and underserved population. Data from national HIV/AIDS surveillance systems and the Behavioral Risk Factor Surveillance System (BRFSS) were examined to delineate the magnitude and course of the HIV/AIDS epidemic among APIs in the United States. Same-sex sexual activity is the main HIV risk for API men, whereas heterosexual contact is for API women. APIs are significantly less likely to report being tested for HIV despite the fact that a similar proportion of APIs and other racial/ethnic groups reported having HIV risk in the past 12 months. Given the enormous diversity among APIs in the United States it is important to collect detailed demographic information to improve race/ethnicity and HIV risk classification, conduct better behavioral and disease monitoring for informing prevention planning, and addressing cultural, linguistic, economic and legal barriers to HIV prevention among APIs. Reprinted by permission of Guilford Publications Inc., New York City JF - AIDS education and prevention AU - Zaidi, Irum F AU - Crepaz, Nicole AU - Song, Ruiguang AU - Wan, Choi K AU - Lin, Lillian S AU - Hu, Dale J AU - Sy, Francisco S AD - Centers for Disease Control and Prevention ; National Institutes of Health Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 405 EP - 417 VL - 17 IS - 5 SN - 0899-9546, 0899-9546 KW - Sociology KW - Epidemiology KW - AIDS KW - Health KW - Diseases KW - U.S.A. KW - HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36440010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+education+and+prevention&rft.atitle=Epidemiology+of+HIV%2FAIDS+among+Asians+and+Pacific+islanders+in+the+United+States&rft.au=Zaidi%2C+Irum+F%3BCrepaz%2C+Nicole%3BSong%2C+Ruiguang%3BWan%2C+Choi+K%3BLin%2C+Lillian+S%3BHu%2C+Dale+J%3BSy%2C+Francisco+S&rft.aulast=Zaidi&rft.aufirst=Irum&rft.date=2005-10-01&rft.volume=17&rft.issue=5&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=AIDS+education+and+prevention&rft.issn=08999546&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4357 7894; 3617 6220; 482 3617 6220; 5703 3617 6220; 5772; 433 293 14 ER - TY - JOUR T1 - HIV/AIDS among Asians and Pacific islanders in the United States AN - 36438819; 3331559 JF - AIDS education and prevention AU - Choi, Kyung-Hee AU - Wong, Frank AU - Zaidi, Irum F AU - Crepaz, Nicole AU - Song, Ruiguang AU - Wan, Choi K AU - Lin, Lillian S AU - Hu, Dale J AU - Sy, Francisco S AU - Operario, Don AU - Gregorich, Steven E AU - McFarland, Willi AU - MacKellar, Duncan AU - Valleroy, Linda AU - Nemoto, Tooru AU - Iwamoto, Mariko AU - Oh, Hyun Joo AU - Wong, Serena AU - Nguyen, Hongmai AU - So, Dominicus W AU - DeLeon, Jordana M AU - Lin, Peter AU - Simoni, Jane M AU - Zemon, Vance AU - Chin, John J AU - Mantell, Joanne AU - Weiss, Linda AU - Bhagavan, Mamatha AU - Luo, Xiaoting AD - University of California ; Georgetown University ; Centers for Disease Control and Prevention ; National Institutes of Health ; University California ; San Francisco Department of Public Health ; Howard University ; Columbia University ; University of Washington ; Yeshiva University ; New York Academy of Medicine Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 405 EP - 502 VL - 17 IS - 5 SN - 0899-9546, 0899-9546 KW - Sociology KW - Sexual behaviour KW - AIDS KW - Immigrants KW - Health KW - Homosexuality KW - U.S.A. KW - Students KW - Models KW - Risk KW - Prevention KW - Sex workers KW - Epidemiology KW - Transsexuality KW - Religious institutions KW - Drug use KW - HIV KW - Sexual intercourse KW - Sex UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36438819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+education+and+prevention&rft.atitle=HIV%2FAIDS+among+Asians+and+Pacific+islanders+in+the+United+States&rft.au=Choi%2C+Kyung-Hee%3BWong%2C+Frank%3BZaidi%2C+Irum+F%3BCrepaz%2C+Nicole%3BSong%2C+Ruiguang%3BWan%2C+Choi+K%3BLin%2C+Lillian+S%3BHu%2C+Dale+J%3BSy%2C+Francisco+S%3BOperario%2C+Don%3BGregorich%2C+Steven+E%3BMcFarland%2C+Willi%3BMacKellar%2C+Duncan%3BValleroy%2C+Linda%3BNemoto%2C+Tooru%3BIwamoto%2C+Mariko%3BOh%2C+Hyun+Joo%3BWong%2C+Serena%3BNguyen%2C+Hongmai%3BSo%2C+Dominicus+W%3BDeLeon%2C+Jordana+M%3BLin%2C+Peter%3BSimoni%2C+Jane+M%3BZemon%2C+Vance%3BChin%2C+John+J%3BMantell%2C+Joanne%3BWeiss%2C+Linda%3BBhagavan%2C+Mamatha%3BLuo%2C+Xiaoting&rft.aulast=Choi&rft.aufirst=Kyung-Hee&rft.date=2005-10-01&rft.volume=17&rft.issue=5&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=AIDS+education+and+prevention&rft.issn=08999546&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - SuppNotes - Collection of 7 articles N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4357 7894; 3753 3755; 5969 11579 11538; 11567 11563 1025 1542 11325 6071; 11035; 11563 1025 1542 11325 6071; 12947 11579 11538; 11556 13682; 11538; 12334 4049; 8163; 6232 8037; 10072; 10813 6590; 482 3617 6220; 5703 3617 6220; 5772; 433 293 14 ER - TY - JOUR T1 - Prolonged Hospital Stay for Extremely Premature Infants: Risk Factors, Center Differences, and the Impact of Mortality on Selecting a Best-Performing Center AN - 220439406; 16079906 AB - The first objective was to identify factors associated with prolonged hospital stay (PHS: hospitalized >42 weeks postmenstrual age) in extremely premature (EP: born less than or equal to 28 weeks gestation) infants. The second objective was to identify a PHS best-performing benchmark center. This study was a retrospective cohort analysis of infants born < or =28 weeks gestation and admitted to one of 12 tertiary centers between January 1998 and October 2001. Risk-adjusted odds of PHS, defined as hospitalization beyond 42 weeks postmenstrual age, and the competing outcome, mortality, were assessed using logistic regression models. Among 3892 EP survivors who had complete data for multivariable analysis, 685 (18%) had PHS. Variables contributing to PHS included chronic lung disease (oxygen use at discharge home or 36 week postmenstrual age) (OR 6.75; 95% CI: 5.04 to 9.03), necrotizing enterocolitis requiring surgery (OR 13.83; 95% CI: 8.05 to 23.76), and >two episodes of late-onset sepsis (OR 2.39; 95% CI: 1.66 to 3.44). Centers' risk-adjusted PHS odds differed from the reference center, which had the lowest incidence of PHS and mortality (overall P-value <0.0001). Mortality contributed to PHS, but in an opposite direction compared to other factors. Centers with lowest PHS odds were among those with highest mortality. These findings suggest that reduction of CLD, surgical NEC, and late onset sepsis could reduce PHS in EP infants. Risk adjusted odds of PHS and mortality are both crucial for selecting a PHS best-performing center. JF - Journal of Perinatology AU - Cotten, C Michael AU - Oh, William AU - McDonald, Scott AU - Carlo, Waldemar AU - Fanaroff, Avroy A AU - Duara, Shahnaz AU - Stoll, Barbara AU - Abbot Laptook AU - Poole, Kenneth AU - Wright, Linda L AU - Goldberg, Ronald N Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 650 EP - 5 CY - New York PB - Nature Publishing Group VL - 25 IS - 10 SN - 07438346 KW - Medical Sciences--Pediatrics KW - Logistic Models KW - Risk Factors KW - Humans KW - Treatment Outcome KW - Retrospective Studies KW - Infant, Newborn KW - Length of Stay KW - Infant Mortality KW - Health Facilities -- classification KW - Infant, Premature UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/220439406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Perinatology&rft.atitle=Prolonged+Hospital+Stay+for+Extremely+Premature+Infants%3A+Risk+Factors%2C+Center+Differences%2C+and+the+Impact+of+Mortality+on+Selecting+a+Best-Performing+Center&rft.au=Cotten%2C+C+Michael%3BOh%2C+William%3BMcDonald%2C+Scott%3BCarlo%2C+Waldemar%3BFanaroff%2C+Avroy+A%3BDuara%2C+Shahnaz%3BStoll%2C+Barbara%3BAbbot+Laptook%3BPoole%2C+Kenneth%3BWright%2C+Linda+L%3BGoldberg%2C+Ronald+N&rft.aulast=Cotten&rft.aufirst=C&rft.date=2005-10-01&rft.volume=25&rft.issue=10&rft.spage=650&rft.isbn=&rft.btitle=&rft.title=Journal+of+Perinatology&rft.issn=07438346&rft_id=info:doi/10.1038%2Fsj.jp.7211369 LA - English DB - ProQuest Central N1 - Copyright - Copyright Nature Publishing Group Oct 2005 N1 - Last updated - 2014-04-30 DO - http://dx.doi.org/10.1038/sj.jp.7211369 ER - TY - JOUR T1 - Rehospitalization of Extremely Low Birth Weight (ELBW) Infants: Are There Racial/Ethnic Disparities? AN - 220407556; 16107873 AB - Premature infants are at increased risk for rehospitalization after discharge from the hospital. Racial disparities are known to exist in pediatric health care. To evaluate whether racial disparities exist in the proportion of extremely low birth weight (ELBW) infants rehospitalized prior to 18 months corrected age and the causes of rehospitalization. The National Institute of Child Health and Human Development Neonatal Research Network database was used to identify all ELBW infants (n=2446) who were born between November 1, 1998 and May 31, 2000 at the 14 participating centers and discharged alive (n=1591). Infants were seen at 18-22 months corrected age for followup. Data related to maternal variables, race, socioeconomic status, medical morbidities, insurance, and rehospitalizations were recorded from the medical record and parent interview. Logistic regression analyses were used to examine the relationship of race/ethnicity and rehospitalization while controlling for gestational age, gender, center, maternal education, family income, bronchopulmonary dysplasia (BPD), necrotizing enterocolitis, ventriculoperitoneal (VP) shunt, respiratory syncytial virus (RSV) prophylaxis, and insurance type. In all, 1405 (88%) infants were evaluated at followup. The racial distribution of infants admitted, discharged, seen at followup, and rehospitalized were similar. Rehospitalization occurred at least once in 49% of the infants. In the logistic regression analyses, race was not a significant predictor for rehospitalization. The odds of rehospitalization were related to low family income, type of insurance, BPD, VP shunt, RSV prophylaxis, and center. Race was not a predominant variable in the risk of rehospitalization in this cohort of ELBW infants. Medical morbidities and low family income appear to be the major risk factors for rehospitalization. JF - Journal of Perinatology AU - Morris, Brenda H AU - Gard, Charlotte C AU - Kennedy, Kathleen Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 656 EP - 63 CY - New York PB - Nature Publishing Group VL - 25 IS - 10 SN - 07438346 KW - Medical Sciences--Pediatrics KW - United States KW - Regression Analysis KW - Humans KW - Infant, Newborn KW - African Americans KW - Morbidity KW - Income KW - Socioeconomic Factors KW - Infant KW - Hispanic Americans KW - Insurance, Health KW - Databases, Factual KW - Female KW - Male KW - Patient Readmission -- statistics & numerical data KW - Infant, Very Low Birth Weight KW - Continental Population Groups UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/220407556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Perinatology&rft.atitle=Rehospitalization+of+Extremely+Low+Birth+Weight+%28ELBW%29+Infants%3A+Are+There+Racial%2FEthnic+Disparities%3F&rft.au=Morris%2C+Brenda+H%3BGard%2C+Charlotte+C%3BKennedy%2C+Kathleen&rft.aulast=Morris&rft.aufirst=Brenda&rft.date=2005-10-01&rft.volume=25&rft.issue=10&rft.spage=656&rft.isbn=&rft.btitle=&rft.title=Journal+of+Perinatology&rft.issn=07438346&rft_id=info:doi/10.1038%2Fsj.jp.7211361 LA - English DB - ProQuest Central N1 - Copyright - Copyright Nature Publishing Group Oct 2005 N1 - Last updated - 2014-04-30 DO - http://dx.doi.org/10.1038/sj.jp.7211361 ER - TY - JOUR T1 - Summary Report: Early Reproductive Events and Breast Cancer Workshop AN - 215288747; 16419725 AB - A summary report on Reproductive Events and Breast Cancer Workshop is presented. The Workshop was established to provide an integrated scientific assessment of the association between reproductive events and the risk of breast cancer. JF - Issues in Law & Medicine AU - Anonymous Y1 - 2005///Fall PY - 2005 DA - Fall 2005 SP - 161 EP - 5 CY - Terre Haute PB - National Legal Center for the Medically Dependent and Disabled Inc. VL - 21 IS - 2 SN - 87568160 KW - Medical Sciences KW - Workshops KW - Breast cancer KW - Health risk assessment KW - Pregnancy KW - United States KW - Education KW - Humans KW - Health Knowledge, Attitudes, Practice KW - Female KW - Reproductive Behavior KW - Breast Neoplasms -- etiology KW - Risk Assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/215288747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acriminaljusticeperiodicals&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Issues+in+Law+%26+Medicine&rft.atitle=Summary+Report%3A+Early+Reproductive+Events+and+Breast+Cancer+Workshop&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2005-10-01&rft.volume=21&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Issues+in+Law+%26+Medicine&rft.issn=87568160&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright National Legal Center for the Medically Dependent & Disabled Inc. Fall 2005 N1 - Last updated - 2014-12-13 ER - TY - JOUR T1 - Cancer Facts: Abortion, Miscarriage, and Breast Cancer Risk AN - 215288670; 16419724 AB - A woman's hormone levels normally change throughout her life for a variety of reasons, and these hormonal change can lead to changes in her breasts. Here, several extensive research on the relationship between induced and spontaneous abortion and breast cancer risk later in life are described. JF - Issues in Law & Medicine AU - Anonymous Y1 - 2005///Fall PY - 2005 DA - Fall 2005 SP - 159 EP - 60 CY - Terre Haute PB - National Legal Center for the Medically Dependent and Disabled Inc. VL - 21 IS - 2 SN - 87568160 KW - Medical Sciences KW - Medical research KW - Abortion KW - Miscarriage KW - Breast cancer KW - Women KW - Health risk assessment KW - United States KW - Risk Factors KW - Humans KW - Female KW - Abortion, Induced KW - Breast Neoplasms -- etiology KW - Abortion, Spontaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/215288670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acriminaljusticeperiodicals&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Issues+in+Law+%26+Medicine&rft.atitle=Cancer+Facts%3A+Abortion%2C+Miscarriage%2C+and+Breast+Cancer+Risk&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2005-10-01&rft.volume=21&rft.issue=2&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Issues+in+Law+%26+Medicine&rft.issn=87568160&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright National Legal Center for the Medically Dependent & Disabled Inc. Fall 2005 N1 - Last updated - 2014-12-13 ER - TY - JOUR T1 - A model of lysosomal metabolism of dextran coated superparamagnetic iron oxide (SPIO) nanoparticles: implications for cellular magnetic resonance imaging AN - 21067493; 8632077 AB - Ferumoxides, dextran-coated superparamagnetic iron oxide (SPIO) particles, form ferumoxide-transfection agent (FE-TA) complexes that are internalized into endosomes/lysosomes and have been used to label cells for in vivo MRI tracking and localization studies. A better understanding of the physical state of the FE-TA complexes during endocytosis could improve their use. The purpose of this study was to measure the rate of the degradation of iron particles under varying physiological conditions. FE-TA complexes were incubated in seven different buffers containing different chelates with different pH. Reducible iron concentrations, T2 relaxation rates and gradient echo (GRE) magnetic resonance images (MRI) were obtained from each condition immediately after incubation and at 6, 24, 48, 72 and 96h and days 7, 14 and 21. The dynamics of FE-TA in the endosome/lysomes within the cells were visualized with electron microscopy. Sodium citrate buffer at pH 4.5 rapidly dissolved FE-TA complexes. However, FE-TA complexes were less soluble in the same buffer at pH 5.5. Similarly, FE-TA complexes were not readily soluble in any of the other buffers with or without chelates, regardless of pH. Electron microscopic images showed degraded FE-TA in some intracellular endosome/lysosomes between days 3 and 5. In the cellular environment, some of the FE-TA-containing endosomes were found to fuse with lysosomes, causing rapid dissociation at low pH and exposing the iron core to chelates that resulted in soluble Fe(III) within the lysosomes. The studies presented represent a first step in identifying the important cellular environmental parameters affecting the integrity of FE-TA complexes. Published in 2005 by John Wiley & Sons, Ltd. JF - NMR in Biomedicine AU - Arbab, Ali S AU - Wilson, Lindsey B AU - Ashari, Parwana AU - Jordan, Elaine K AU - Lewis, Bobbi K AU - Frank, Joseph A AD - Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, National Institutes of Health, Bethesda, Maryland, USA, Saali@rad.hfh.edu Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 383 EP - 389 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 18 IS - 6 SN - 0952-3480, 0952-3480 KW - Biotechnology and Bioengineering Abstracts KW - sodium citrate KW - Dextran KW - iron oxides KW - Magnetic resonance imaging KW - Endocytosis KW - endosomes KW - N.M.R. KW - Chelates KW - nanoparticles KW - Iron KW - pH effects KW - Electron microscopy KW - Metabolism KW - Lysosomes KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21067493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=A+model+of+lysosomal+metabolism+of+dextran+coated+superparamagnetic+iron+oxide+%28SPIO%29+nanoparticles%3A+implications+for+cellular+magnetic+resonance+imaging&rft.au=Arbab%2C+Ali+S%3BWilson%2C+Lindsey+B%3BAshari%2C+Parwana%3BJordan%2C+Elaine+K%3BLewis%2C+Bobbi+K%3BFrank%2C+Joseph+A&rft.aulast=Arbab&rft.aufirst=Ali&rft.date=2005-10-01&rft.volume=18&rft.issue=6&rft.spage=383&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=09523480&rft_id=info:doi/10.1002%2Fnbm.970 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - pH effects; Lysosomes; endosomes; Magnetic resonance imaging; Iron; Chelates; iron oxides; nanoparticles; N.M.R.; Metabolism; Dextran; Endocytosis; Electron microscopy; sodium citrate DO - http://dx.doi.org/10.1002/nbm.970 ER - TY - JOUR T1 - Normal and Cystic Fibrosis Airway Surface Liquid Homeostasis: THE EFFECTS OF PHASIC SHEAR STRESS AND VIRAL INFECTIONS AN - 21044834; 6503552 AB - Mammalian airways normally regulate the volume of a thin liquid layer, the periciliary liquid (PCL), to facilitate the mucus clearance component of lung defense. Studies under standard (static) culture conditions revealed that normal airway epithelia possess an adenosine-regulated pathway that blends Na super(+) absorption and Cl super(-) secretion to optimize PCL volume. In cystic fibrosis (CF), the absence of CF transmembrane conductance regulator results in a failure of adenosine regulation of PCL volume, which is predicted to initiate mucus stasis and infection. However, under conditions that mimic the phasic motion of the lung in vivo, ATP release into PCL was increased, CF ion transport was rebalanced, and PCL volume was restored to levels adequate for lung defense. This ATP signaling system was vulnerable, however, to insults that trigger CF bacterial infections, such as viral (respiratory syncitial virus) infections, which up-regulated extracellular ATPase activity and abolished motion-dependent ATP regulation of CF PCL height. These studies demonstrate (i) how the normal coordination of opposing ion transport pathways to maintain PCL volume is disrupted in CF, (ii) the hitherto unknown role of phasic motion in regulating key aspects of normal and CF innate airways defense, and (iii) that maneuvers directed at increasing motion-induced nucleotide release may be therapeutic in CF patients. JF - Journal of Biological Chemistry AU - Tarran, Robert AU - Button, Brian AU - Picher, Maryse AU - Paradiso, Anthony M AU - Ribeiro, Carla M AU - Lazarowski, Eduardo R AU - Zhang, Liqun AU - Collins, Peter L AU - Pickles, Raymond J AU - Fredberg, Jeffrey J AU - Boucher, Richard C AD - Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7248, Laboratory of Infectious Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892-0720, and School of Public Health, Harvard University, Boston, Massachusetts 02115 Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 35751 EP - 35759 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 280 IS - 42 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Adenosinetriphosphatase KW - Secretion KW - ATP KW - Chloride KW - Mucus KW - Homeostasis KW - Infection KW - Nucleotides KW - Mechanical stimuli KW - Lung KW - Adenosine KW - Cystic fibrosis KW - Signal transduction KW - Respiratory tract KW - J 02410:Animal Diseases KW - V 22320:Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21044834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Normal+and+Cystic+Fibrosis+Airway+Surface+Liquid+Homeostasis%3A+THE+EFFECTS+OF+PHASIC+SHEAR+STRESS+AND+VIRAL+INFECTIONS&rft.au=Tarran%2C+Robert%3BButton%2C+Brian%3BPicher%2C+Maryse%3BParadiso%2C+Anthony+M%3BRibeiro%2C+Carla+M%3BLazarowski%2C+Eduardo+R%3BZhang%2C+Liqun%3BCollins%2C+Peter+L%3BPickles%2C+Raymond+J%3BFredberg%2C+Jeffrey+J%3BBoucher%2C+Richard+C&rft.aulast=Tarran&rft.aufirst=Robert&rft.date=2005-10-01&rft.volume=280&rft.issue=42&rft.spage=35751&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Adenosinetriphosphatase; Secretion; ATP; Mucus; Chloride; Homeostasis; Infection; Nucleotides; Mechanical stimuli; Lung; Cystic fibrosis; Adenosine; Respiratory tract; Signal transduction ER - TY - JOUR T1 - Variable Tick Protein in Two Genomic Groups of the Relapsing Fever Spirochete Borrelia hermsii in Western North America AN - 20983771; 6527448 AB - Borrelia hermsii is the primary cause of tick-borne relapsing fever in North America. When its tick vector, Ornithodoros hermsi, acquires these spirochetes from the blood of an infected mammal, the bacteria switch their outer surface from one of many bloodstream variable major proteins (Vmps) to a unique protein, Vtp (Vsp33). Vtp may be critical for successful tick transmission of B. hermsii; however, the gene encoding this protein has been described previously in only one isolate. Here we identified and sequenced the vtp gene in 31 isolates of B. hermsii collected over 40 years from localities throughout much of its known geographic distribution. Seven major Vtp types were found. Little or no sequence variation existed within types, but between them significant variation was observed, similar to the pattern of diversity described for the outer surface protein C (OspC) gene in Lyme disease spirochetes. The pattern of sequence relatedness among the Vtp types was incongruent in two branches compared to two genomic groups identified among the isolates by multilocus sequence typing of the 16S rRNA, flaB, gyrB, and glpQ genes. Therefore, both horizontal transfer and recombination within and between the two genomic groups were responsible for some of the variation observed in the vtp gene. O. hermsi ticks were capable of transmitting spirochetes in the newly identified genomic group. Therefore, given the longevity of the tick vector and persistent infection of spirochetes in ticks, these arthropods rather than mammals may be the likely host where the exchange of spirochetal DNA occurs. JF - Infection and Immunity AU - Porcella, Stephen F AU - Raffel, Sandra J AU - Anderson, Donald EJr AU - Gilk, Stacey D AU - Bono, James L AU - Schrumpf, Merry E AU - Schwan, Tom G AD - Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, Montana. Sacred Heart Medical Center, Spokane, Washington Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 6647 EP - 6658 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 73 IS - 10 SN - 0019-9567, 0019-9567 KW - Genetics Abstracts; Entomology Abstracts; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Borrelia hermsii KW - Geographical distribution KW - Relapsing fever KW - Persistent infection KW - Disease transmission KW - Recombination KW - outer surface protein C KW - tick-borne diseases KW - ospC gene KW - genomics KW - Lyme disease KW - North America KW - tick-borne relapsing fever KW - Ixodidae KW - DNA topoisomerase KW - Vectors KW - Horizontal transfer KW - Longevity KW - multilocus sequence typing KW - Blood KW - Spirochetes KW - Arthropoda KW - DNA KW - rRNA 16S KW - Ornithodoros KW - J 02870:Invertebrate bacteriology KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - F 06910:Microorganisms & Parasites KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20983771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Variable+Tick+Protein+in+Two+Genomic+Groups+of+the+Relapsing+Fever+Spirochete+Borrelia+hermsii+in+Western+North+America&rft.au=Porcella%2C+Stephen+F%3BRaffel%2C+Sandra+J%3BAnderson%2C+Donald+EJr%3BGilk%2C+Stacey+D%3BBono%2C+James+L%3BSchrumpf%2C+Merry+E%3BSchwan%2C+Tom+G&rft.aulast=Porcella&rft.aufirst=Stephen&rft.date=2005-10-01&rft.volume=73&rft.issue=10&rft.spage=6647&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-01-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Geographical distribution; tick-borne relapsing fever; Relapsing fever; DNA topoisomerase; Vectors; Persistent infection; Longevity; Horizontal transfer; multilocus sequence typing; Disease transmission; Spirochetes; Blood; Recombination; outer surface protein C; tick-borne diseases; DNA; ospC gene; genomics; rRNA 16S; Lyme disease; Borrelia hermsii; Arthropoda; Ixodidae; Ornithodoros; North America ER - TY - JOUR T1 - S5FP: Spectrally selective suppression with steady state free precession AN - 20855769; 8367905 AB - A method is presented that employs the inherent spectral selectivity of the Steady-State Free Precession (SSFP) pulse sequence to provide a spectral band of suppression. At TE = TR/2, SSFP partitions the magnetization into two phase-opposed spectral components. Z-storing one of these components simultaneously further excites the other, which is then suppressed by gradient crushing and RF spoiling. The Spectrally Selective Suppression with SSFP (S5FP) method is shown to provide significant attenuation of fat signals, while the water signals are essentially unaffected and provide the normal SSFP contrast. Fat suppression is achieved with relatively little temporal overhead (less than 10% reduction in temporal resolution). S5FP was validated using simulations, phantoms, and human studies. JF - Magnetic Resonance in Medicine AU - Derbyshire, J A AU - Herzka, D A AU - McVeigh, E R AD - Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, MD 20892-1061, USA, jad11@nih.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 918 EP - 928 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 54 IS - 4 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - N.M.R. KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20855769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=S5FP%3A+Spectrally+selective+suppression+with+steady+state+free+precession&rft.au=Derbyshire%2C+J+A%3BHerzka%2C+D+A%3BMcVeigh%2C+E+R&rft.aulast=Derbyshire&rft.aufirst=J&rft.date=2005-10-01&rft.volume=54&rft.issue=4&rft.spage=918&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20633 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - N.M.R. DO - http://dx.doi.org/10.1002/mrm.20633 ER - TY - JOUR T1 - Evolutionary and functional genomics of the Archaea AN - 20851273; 8336564 AB - In the past two years, archaeal genomics has achieved several breakthroughs. On the evolutionary front the most exciting development was the sequencing and analysis of the genome of Nanoarchaeum equitans, a tiny parasitic organism that has only 540 genes. The genome of Nanoarchaeum shows signs of extreme rearrangement including the virtual absence of conserved operons and the presence of several split genes. Nanoarchaeum is distantly related to other archaea, and it has been proposed to represent a deep archaeal branch that is distinct from Euryarchaeota and Crenarchaeota. This would imply that many features of its gene repertoire and genome organization might be ancestral. However, additional genome analysis has provided a more conservative suggestion - that Nanoarchaeum is a highly derived euryarchaeon. Also there have been substantial developments in functional genomics, including the discovery of the elusive aminoacyl-tRNA synthetase that is involved in both the biosynthesis of cysteine and its incorporation into proteins in methanogens, and the first experimental validation of the predicted archaeal exosome. JF - Current Opinion in Microbiology AU - Makarova, Kira S AU - Koonin, Eugene V AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, koonin@ncbi.nlm.nih.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 586 EP - 594 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 8 IS - 5 SN - 1369-5274, 1369-5274 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Archaea KW - exosomes KW - Nanoarchaeum equitans KW - Methanogenic bacteria KW - Crenarchaeota KW - Cysteine KW - Reviews KW - Euryarchaeota KW - genomics KW - Aminoacyl-tRNA ligase KW - Operons KW - Evolution KW - J 02310:Genetics & Taxonomy KW - N 14845:Miscellaneous KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20851273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Microbiology&rft.atitle=Evolutionary+and+functional+genomics+of+the+Archaea&rft.au=Makarova%2C+Kira+S%3BKoonin%2C+Eugene+V&rft.aulast=Makarova&rft.aufirst=Kira&rft.date=2005-10-01&rft.volume=8&rft.issue=5&rft.spage=586&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Microbiology&rft.issn=13695274&rft_id=info:doi/10.1016%2Fj.mib.2005.08.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - exosomes; Cysteine; Reviews; Aminoacyl-tRNA ligase; genomics; Operons; Methanogenic bacteria; Evolution; Crenarchaeota; Archaea; Nanoarchaeum equitans; Euryarchaeota DO - http://dx.doi.org/10.1016/j.mib.2005.08.003 ER - TY - JOUR T1 - Radiosyntheses and reactivities of novel [ super(18)F]2-fluoroethyl arylsulfonates AN - 20796092; 6462915 AB - [ super(18)F]2-Fluoroethyl tosylate ([ super(18)F]FEOX, X=Ts) is widely used for labeling radiotracers for positron emission tomography (PET). Little work has been reported on syntheses of other [ super(18)F]2-fluoroethyl arylsulfonates ([ super(18)F]FEOX) that bear a less electron-rich aryl group, even though these might offer enhanced reactivities. Thus, a series of novel [ super(18)F]FEOX (X=benzenesulfonyl, brosyl, nosyl, 3,4-dibromobenzenesulfonyl) were synthesized and reactivities compared to [ super(18)F]FEOTs. Precursors for radiolabeling (bis- ethylene glycol arylsulfonates) and reference FEOX were synthesized (alcohol+arylsulfonyl chloride+KOSiMe sub(3) in THF). Regardless of substitution pattern, [ super(18)F]FEOX (110 degree C, 5 min, acetonitrile) were obtained in similar decay-corrected isolated radiochemical yields (RCY; 47-53%). All [ super(18)F]FEOX gave excellent RCYs (64-87%) of the dopamine uptake radioligand, [ super(18)F]FECNT (130 degree C, 10 min, acetonitrile). The 3,4-dibromobenzensulfonate gave the highest RCY of [ super(18)F]FECNT (87%) and this HPLC-purified labeling agent was used directly for efficient [ super(18)F]FECNT production. When the secondary aniline of an amyloid probe (HM-IMPY) or p-nitrophenol was reacted with [ super(18)F]FEOX, RCYs were appreciably higher for brosylate and nosylate than for tosylate, while 3,4- dibromobenzenesulfonate again gave the highest RCY. Owing to the high reactivity of the new [ super(18)F]FEOX and their ease of syntheses via stable precursors, such agents (particularly 3,4-dibromobenzenesulfonate) should be considered as alternatives to [ super(18)F]FEOTs. JF - Journal of Labelled Compounds and Radiopharmaceuticals AU - Musachio, John L AU - Shah, Jay AU - Pike, Victor W AD - PET Radiopharmaceutical Sciences, Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3 C346, 10 Center Drive, Bethesda, MD 20892-1003, USA, john.musachio@nih.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 735 EP - 747 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 48 IS - 10 SN - 0362-4803, 0362-4803 KW - Biotechnology and Bioengineering Abstracts KW - Dopamine KW - Probes KW - Positron emission tomography KW - p-Nitrophenol KW - Ethylene glycol KW - Acetonitrile KW - Aniline KW - Amyloid KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20796092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Labelled+Compounds+and+Radiopharmaceuticals&rft.atitle=Radiosyntheses+and+reactivities+of+novel+%5B+super%2818%29F%5D2-fluoroethyl+arylsulfonates&rft.au=Musachio%2C+John+L%3BShah%2C+Jay%3BPike%2C+Victor+W&rft.aulast=Musachio&rft.aufirst=John&rft.date=2005-10-01&rft.volume=48&rft.issue=10&rft.spage=735&rft.isbn=&rft.btitle=&rft.title=Journal+of+Labelled+Compounds+and+Radiopharmaceuticals&rft.issn=03624803&rft_id=info:doi/10.1002%2Fjlcr.991 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Acetonitrile; Positron emission tomography; Probes; Amyloid; Aniline; Ethylene glycol; p-Nitrophenol; Dopamine DO - http://dx.doi.org/10.1002/jlcr.991 ER - TY - JOUR T1 - Radiation Sensitivity of Human Carcinoma Cells Transfected with Small Interfering RNA Targeted against Cyclooxygenase-2 AN - 20715213; 6508654 AB - PURPOSE: Cyclooxygenase-2 (COX-2) is considered a potential target for cancer therapy, because COX-2 levels are elevated in the majority of human tumors compared with the normal tissues. COX-2 inhibitors inhibit tumor growth and enhance radiation response in vitro as well as in vivo. However, the precise role of COX-2 in radiation response is not clear. The purpose of the present study was to investigate the in vitro radiosensitivity of tumor cells as a function of COX-2 expression. Experimental Design and Results: PC3 and HeLa cells express COX-2 protein constitutively. We silenced the COX-2 gene in these cells using small interfering RNA (siRNA). Transfection of PC3 cells with 100 nmol/L siRNA targeted against COX-2 resulted in reduction of COX-2 protein by 75% and inhibition of arachidonic acid-induced prostaglandin E sub(2) synthesis by similar to 50% compared with the vehicle control. In HeLa cells, 100 nmol/L COX-2 siRNA inhibited COX-2 protein expression by 80%. Cell cycle analysis showed that transfection with COX-2 siRNA did not alter the cell cycle distribution. Radiosensitivity was determined by clonogenic cell survival assay. There was no significant difference in the radiosensitivity of cells in which COX-2 was silenced compared with the cells transfected vehicle or with negative control siRNAs (enhancement ratio = 1.1). CONCLUSIONS: These data indicate that the in vitro radiosensitivity of tumor cells is minimally dependent on the cellular COX-2 status. Given that a number of potential mechanisms are attributed to COX-2 inhibitors for radiosensitization, specific intervention of COX-2 by RNA interference could help elucidate the precise role of COX-2 in cancer therapy and to optimize strategies for COX-2 inhibition. JF - Clinical Cancer Research AU - Palayoor, Sanjeewani T AU - Arayankalayil, Moly J AU - Shoaibi, Azadeh AU - Coleman, CNorman AD - Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2005/10/01/ PY - 2005 DA - 2005 Oct 01 SP - 6980 EP - 6986 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 11 IS - 19 SN - 1078-0432, 1078-0432 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Cell survival KW - Cyclooxygenase-2 KW - Data processing KW - Cell cycle KW - Radiosensitization KW - Prostaglandin E2 KW - Tumors KW - Tumor cells KW - Cancer KW - Carcinoma KW - Radiation KW - siRNA KW - Transfection KW - RNA-mediated interference KW - Radiosensitivity KW - Gene silencing KW - N 14830:RNA KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20715213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Radiation+Sensitivity+of+Human+Carcinoma+Cells+Transfected+with+Small+Interfering+RNA+Targeted+against+Cyclooxygenase-2&rft.au=Palayoor%2C+Sanjeewani+T%3BArayankalayil%2C+Moly+J%3BShoaibi%2C+Azadeh%3BColeman%2C+CNorman&rft.aulast=Palayoor&rft.aufirst=Sanjeewani&rft.date=2005-10-01&rft.volume=11&rft.issue=19&rft.spage=6980&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cyclooxygenase-2; Cell survival; Data processing; Cell cycle; Radiosensitization; Tumors; Prostaglandin E2; Tumor cells; Cancer; Carcinoma; siRNA; Radiation; Transfection; Radiosensitivity; RNA-mediated interference; Gene silencing ER - TY - JOUR T1 - Rational Development of Histone Deacetylase Inhibitors as Anticancer Agents: A Review AN - 20220856; 6528637 AB - The epigenome is defined by DNA methylation patterns and the associated post-translational modifications of histones. This histone code determines the expression status of individual genes dependent upon their localization on the chromatin. The histone deacetylases (HDACs) play a major role in keeping the balance between the acetylated and deacetylated states of chromatin and eventually regulate gene expression. Recent developments in understanding the cancer cell cycle, specifically the interplay with chromatin control, are providing opportunities for developing mechanism-based therapeutic drugs. Inhibitors of HDACs are under considerable exploration, in part because of their potential roles in reversing the silenced genes in transformed tumor cells by modulating transcriptional processes. This review is an effort to summarize the nonclinical and clinical status of HDAC inhibitors currently under development in anticancer therapy. JF - Molecular Pharmacology AU - Acharya, Milin R AU - Sparreboom, Alex AU - Venitz, Juergen AU - Figg, William D AD - Clinical Pharmacology Research Core, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (M.R.A., A.S., W.D.F.) Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 917 EP - 932 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 USA, [URL:http://www.lww.com/] VL - 68 IS - 4 SN - 0026-895X, 0026-895X KW - Biotechnology and Bioengineering Abstracts KW - Histone deacetylase KW - Chromatin KW - Post-translation KW - Reviews KW - Cell cycle KW - DNA methylation KW - Transcription KW - Antitumor agents KW - Tumor cells KW - Cancer KW - Gene silencing KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20220856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Pharmacology&rft.atitle=Rational+Development+of+Histone+Deacetylase+Inhibitors+as+Anticancer+Agents%3A+A+Review&rft.au=Acharya%2C+Milin+R%3BSparreboom%2C+Alex%3BVenitz%2C+Juergen%3BFigg%2C+William+D&rft.aulast=Acharya&rft.aufirst=Milin&rft.date=2005-10-01&rft.volume=68&rft.issue=4&rft.spage=917&rft.isbn=&rft.btitle=&rft.title=Molecular+Pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Histone deacetylase; Post-translation; Chromatin; Reviews; Cell cycle; DNA methylation; Transcription; Tumor cells; Antitumor agents; Cancer; Gene silencing ER - TY - JOUR T1 - Diminished Lipoxin Biosynthesis in Severe Asthma AN - 199579013; 15961693 AB - Severe asthma is characterized by increased airway inflammation that persists despite therapy with corticosteroids. It is not, however, merely an exaggeration of the eosinophilic inflammation that characterizes mild to moderate asthma; rather, severe asthma presents unique features. Although arachidonic acid metabolism is well appreciated to regulate airway inflammation and reactivity, alterations in the biosynthetic capacity for both pro- and antiinflammatory eicosanoids in severe asthma have not been determined. Patients with severe asthma were identified according to National Heart, Lung, and Blood Institute Severe Asthma Research Program criteria. Samples of whole blood from individuals with severe or moderate asthma were assayed for biosynthesis of lipoxygenase-derived eicosanoids. The counterregulatory mediator lipoxin A4 was detectable in low picogram amounts, using a novel fluorescence-based detection system. In activated whole blood, mean lipoxin A4 levels were decreased in severe compared with moderate asthma (0.4 [SD 0.4] ng/ml vs. 1.8 [SD 0.8] ng/ml, p=0.001). In sharp contrast, mean levels of prophlogistic cysteinyl leukotrienes were increased in samples from severe compared with moderate asthma (112.5 [SD 53.7] pg/ml vs. 64.4 [SD 24.8] pg/ml, p=0.03). Basal circulating levels of lipoxin A4 were also decreased in severe relative to moderate asthma. The marked imbalance in lipoxygenase-derived eicosanoid biosynthesis correlated with the degree of airflow obstruction. Mechanisms underlying airway responses in severe asthma include underproduction of lipoxins. This is the first report of a defect in lipoxin biosynthesis in severe asthma, and suggests an alternative therapeutic strategy that emphasizes natural counterregulatory pathways in the airways. JF - American Journal of Respiratory and Critical Care Medicine AU - Levy, Bruce D AU - Bonnans, Caroline AU - Silverman, Eric S AU - Palmer, Lyle J AU - et al Y1 - 2005/10/01/ PY - 2005 DA - 2005 Oct 01 SP - 824 EP - 30 CY - New York PB - American Thoracic Society VL - 172 IS - 7 SN - 1073449X KW - Medical Sciences--Respiratory Diseases KW - Lipoxins KW - Membrane Proteins KW - Receptors, Leukotriene KW - leukotriene D4 receptor KW - lipoxin A4 KW - Sputum -- chemistry KW - Membrane Proteins -- metabolism KW - Humans KW - Adult KW - Chromatography, High Pressure Liquid -- methods KW - Receptors, Leukotriene -- metabolism KW - Forced Expiratory Volume KW - Male KW - Female KW - Asthma -- physiopathology KW - Asthma -- metabolism KW - Lipoxins -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/199579013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Diminished+Lipoxin+Biosynthesis+in+Severe+Asthma&rft.au=Levy%2C+Bruce+D%3BBonnans%2C+Caroline%3BSilverman%2C+Eric+S%3BPalmer%2C+Lyle+J%3Bet+al&rft.aulast=Levy&rft.aufirst=Bruce&rft.date=2005-10-01&rft.volume=172&rft.issue=7&rft.spage=824&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Thoracic Society Oct 1, 2005 N1 - Last updated - 2017-01-07 ER - TY - JOUR T1 - Transvenous Access to the Pericardial Space: An Approach to Epicardial Lead Implantation for Cardiac Resynchronization Therapy AN - 19929413; 6563776 AB - Background: Percutaneous access to the pericardial space (PS) may be useful for a number of therapeutic modalities including implantation of epicardial pacing leads. We have developed a catheter-based transvenous method to access the PS for implanting chronic medical devices. Methods: In eight pigs, a transseptal Mullins sheath and Brockenbrough needle were introduced into the right atrium (RA) from the jugular vein under fluoroscopic guidance. The PS was entered through a controlled puncture of the terminal anterior superior vena cava (SVC) (n = 7) or right atrial appendage (n = 1). A guidewire was advanced through the transseptal sheath, which was then removed leaving the wire in PS. The guidewire was used to direct both passive and active fixation pacing leads into the PS. Pacing was attempted and lead position was confirmed by cine fluoroscopy. Animals were sacrificed acutely and at 2 and 6 weeks. Results: All animals survived the procedure. Pericardial effusion (PE) during the procedure was hemodynamically significant in four of the eight animals. At necropsy, lead exit sites appeared to heal without complication at 2 and 6 weeks. Volume of pericardial fluid was 10.8 plus or minus 6.2 mL and appeared normal in four of the six chronic animals. Moderate fibrinous deposition was observed in two animals, which had exhibited significant over-procedural PE. Conclusions: Access to the PS via a transvenous approach is feasible. Pacing leads can be negotiated into this region. The puncture site heals with the lead in place. Further development should focus on eliminating PE and performing this technique in appropriate heart failure models. JF - Pacing and Clinical Electrophysiology AU - Mickelsen, Steven R AU - Ashikaga, Hiroshi AU - Desilva, Ranil AU - Raval, Amish N AU - Mcveigh, Elliot AU - Kusumoto, Fred AD - Address for reprints: Steven R. Mickelsen, B.A., Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute Bldg. 10 Rm. B1D412 10 Center Drive, Bethesda, MD 20892, smickelsen@salud.unm.edu Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 1018 EP - 1024 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 28 IS - 10 SN - 0147-8389, 0147-8389 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Autopsy KW - Effusion KW - Jugular vein KW - Sheaths KW - Electrophysiology KW - Development KW - Appendages KW - Models KW - fluoroscopy KW - Atrium KW - Heart diseases KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19929413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pacing+and+Clinical+Electrophysiology&rft.atitle=Transvenous+Access+to+the+Pericardial+Space%3A+An+Approach+to+Epicardial+Lead+Implantation+for+Cardiac+Resynchronization+Therapy&rft.au=Mickelsen%2C+Steven+R%3BAshikaga%2C+Hiroshi%3BDesilva%2C+Ranil%3BRaval%2C+Amish+N%3BMcveigh%2C+Elliot%3BKusumoto%2C+Fred&rft.aulast=Mickelsen&rft.aufirst=Steven&rft.date=2005-10-01&rft.volume=28&rft.issue=10&rft.spage=1018&rft.isbn=&rft.btitle=&rft.title=Pacing+and+Clinical+Electrophysiology&rft.issn=01478389&rft_id=info:doi/10.1111%2Fj.1540-8159.2005.00236.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - SuppNotes - Figures, 5; references, 21. N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Autopsy; Effusion; Jugular vein; fluoroscopy; Appendages; Development; Electrophysiology; Sheaths; Atrium; Models; Heart diseases DO - http://dx.doi.org/10.1111/j.1540-8159.2005.00236.x ER - TY - JOUR T1 - Craniospinal Reduced Dose Radiotherapy After Myeoablative Chemotherapy with Peripheral Blood Stem Cells Rescue, in High Risk Medulloblastoma: Results of a Mono-Institutional Study in Italy AN - 19898561; 8067651 JF - International Journal of Radiation Oncology, Biology, & Physics AU - Barra, S AU - Vitale, V AU - Dallorso, S AU - Milanaccio, C AU - Foppiano, F AU - Guenzi, M AU - Rossi, A AU - Pavanello, M AU - Nozza, P AU - Cama, A AU - Garre', M AD - Radiotherapy, National Cancer Institute, Genova, Italy Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 1 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 63 SN - 0360-3016, 0360-3016 KW - Biotechnology and Bioengineering Abstracts KW - Stem cells KW - Chemotherapy KW - Risk factors KW - Medulloblastoma KW - Radiotherapy KW - Peripheral blood KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19898561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Radiation+Oncology%2C+Biology%2C+%26+Physics&rft.atitle=Craniospinal+Reduced+Dose+Radiotherapy+After+Myeoablative+Chemotherapy+with+Peripheral+Blood+Stem+Cells+Rescue%2C+in+High+Risk+Medulloblastoma%3A+Results+of+a+Mono-Institutional+Study+in+Italy&rft.au=Barra%2C+S%3BVitale%2C+V%3BDallorso%2C+S%3BMilanaccio%2C+C%3BFoppiano%2C+F%3BGuenzi%2C+M%3BRossi%2C+A%3BPavanello%2C+M%3BNozza%2C+P%3BCama%2C+A%3BGarre%27%2C+M&rft.aulast=Barra&rft.aufirst=S&rft.date=2005-10-01&rft.volume=63&rft.issue=&rft.spage=S25&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Radiation+Oncology%2C+Biology%2C+%26+Physics&rft.issn=03603016&rft_id=info:doi/10.1016%2Fj.ijrobp.2005.07.050 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Stem cells; Risk factors; Chemotherapy; Medulloblastoma; Radiotherapy; Peripheral blood DO - http://dx.doi.org/10.1016/j.ijrobp.2005.07.050 ER - TY - JOUR T1 - Lymphomatoid Granulomatosis: Abnormalities of the Brain at MR Imaging AN - 19896219; 6529004 AB - PURPOSE: To retrospectively evaluate the magnetic resonance (MR) imaging features of lymphomatoid granulomatosis in the brain. MATERIALS AND METHODS: The study, including retrospective analysis of data, was approved by the institutional review board of the National Cancer Institute and complied with Health Insurance Portability and Accountability Act. All patients gave written informed consent. Thirty-one patients with pathologically confirmed lymphomatoid granulomatosis were enrolled in a natural history and treatment study at the National Institutes of Health. Twenty-five patients (median age, 50 years; range, 18-62 years; 18 men, seven women) were evaluated with MR imaging of the brain at study entry for the presence of brain lesions and enhancing characteristics. Patients with abnormal findings were reexamined at intervals ranging from 2 to 19 months, as medically indicated. Cytologic analysis and flow cytometry of cerebrospinal fluid (CSF) were performed. Statistical analysis was performed to compare neurologic and CSF findings in patients with brain MR imaging abnormalities and in patients without abnormalities. The sensitivity of brain MR imaging was compared with that of CSF studies. RESULTS: Thirteen (52%) of 25 patients evaluated with MR imaging had a variety of brain abnormalities. Multiple focal intraparenchymal lesions, which exhibited T2 prolongation and commonly punctate or linear enhancement, were the most frequent abnormalities, and they were encountered in seven patients. The second most common finding was involvement of leptomeninges and cranial nerves, which manifested as abnormal enhancement on MR images obtained after contrast agent administration. This abnormality was seen in six patients. Involvement of dura mater was noted in another. Four patients had brain masses. Two had abnormal engorgement and intense enhancement of the choroid plexus. Most lesions resolved after treatment, but seven resulted in lacunar infarctions. Abnormal B cells were detected in the CSF with either cytologic techniques or flow cytometry in five patients. CONCLUSION: Lymphomatoid granulomatosis has a high rate of central nervous system involvement and a variable spectrum of lesions at MR imaging. Findings in this study suggest that MR imaging is more sensitive than CSF cytologic analysis or flow cytometry for detection of central nervous system involvement from lymphomatoid granulomatosis. [copy ] RSNA, 2005 JF - Radiology AU - Patsalides, Athos D AU - Atac, Gokce AU - Hedge, Upendra AU - Janik, John AU - Grant, Nicole AU - Jaffe, Elaine S AU - Dwyer, Andrew AU - Patronas, Nicholas J AU - Wilson, Wyndham H AD - Department of Diagnostic Radiology, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bldg 10, Room 1C660, 9000 Rockville Pike, Bethesda, MD 20892-1182 (A.D.P., G.A., A.D., N.J.P.) Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 265 EP - 273 PB - Radiological Society of North America, 820 Jorie Blvd. Oak Brook Illinois 60523-2251 USA VL - 237 IS - 1 SN - 0033-8419, 0033-8419 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Central nervous system KW - Age KW - Neuroimaging KW - Magnetic resonance imaging KW - Statistical analysis KW - Flow cytometry KW - Cerebrospinal fluid KW - Contrast media KW - Dura mater KW - Cranial nerves KW - Granulomatosis KW - Data processing KW - Lymphocytes B KW - Brain KW - Choroid plexus KW - Cancer KW - Infarction KW - Engorgement KW - W 30910:Imaging KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19896219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Lymphomatoid+Granulomatosis%3A+Abnormalities+of+the+Brain+at+MR+Imaging&rft.au=Patsalides%2C+Athos+D%3BAtac%2C+Gokce%3BHedge%2C+Upendra%3BJanik%2C+John%3BGrant%2C+Nicole%3BJaffe%2C+Elaine+S%3BDwyer%2C+Andrew%3BPatronas%2C+Nicholas+J%3BWilson%2C+Wyndham+H&rft.aulast=Patsalides&rft.aufirst=Athos&rft.date=2005-10-01&rft.volume=237&rft.issue=1&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; Cerebrospinal fluid; Granulomatosis; Neuroimaging; Brain; Flow cytometry; Central nervous system; Choroid plexus; Data processing; Contrast media; Statistical analysis; Cranial nerves; Lymphocytes B; Engorgement; Dura mater; Age; Infarction; Cancer ER - TY - JOUR T1 - Viral and cellular RNA helicases as antiviral targets AN - 19890946; 7964374 AB - Although there has been considerable progress in the development of antiviral agents in recent years, there is still a pressing need for new drugs both to improve on the properties of existing agents and to combat the problem of viral resistance. Helicases, both viral and human, have recently emerged as novel targets for the treatment of viral infections. Here, we discuss the role of these enzymes, factors affecting their potential as drug targets and progress in the development of agents that inhibit their activity using the hepatitis C virus-encoded helicase NS3 and the cellular helicase DDX3 adopted for use by HIV-1 as examples. JF - Nature Reviews: Drug Discovery AU - Kwong, Ann D AU - Rao, BGovinda AU - Jeang, Kuan-Teh AD - Vertex Pharmaceuticals Inc., 130 Waverly Street, Cambridge, Massachusetts 02139, USA., kj7e@nih.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 845 EP - 853 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 4 IS - 10 SN - 1474-1784, 1474-1784 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - RNA helicase KW - Antiviral agents KW - Human immunodeficiency virus 1 KW - Enzymes KW - Drug development KW - Hepatitis C KW - Infection KW - DNA helicase KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19890946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Drug+Discovery&rft.atitle=Viral+and+cellular+RNA+helicases+as+antiviral+targets&rft.au=Kwong%2C+Ann+D%3BRao%2C+BGovinda%3BJeang%2C+Kuan-Teh&rft.aulast=Kwong&rft.aufirst=Ann&rft.date=2005-10-01&rft.volume=4&rft.issue=10&rft.spage=845&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Drug+Discovery&rft.issn=14741784&rft_id=info:doi/10.1038%2Fnrd1853 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - RNA helicase; Antiviral agents; Enzymes; Drug development; Hepatitis C; Infection; DNA helicase; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1038/nrd1853 ER - TY - JOUR T1 - HLA-A*0201, HLA-A*1101, and HLA-B*0702 Transgenic Mice Recognize Numerous Poxvirus Determinants from a Wide Variety of Viral Gene Products AN - 19818419; 6504277 AB - In virus models explored in detail in mice, CTL typically focus on a few immunodominant determinants. In this study we use a multipronged approach to understand the diversity of CTL responses to vaccinia virus, a prototypic poxvirus with a genome similar to 20-fold larger than that of the model RNA viruses typically studied in mice. Based on predictive computational algorithms for peptide binding to HLA supertypes, we synthesized a panel of 2889 peptides to begin to create an immunomic map of human CTL responses to poxviruses. Using this panel in conjunction with CTLs from vaccinia virus-infected HLA transgenic mice, we identified 14 HLA-A*0201-, 4 HLA-A*1101-, and 3 HLA-B*0702-restricted CD8 super(+) T cell determinants distributed over 20 distinct proteins. These peptides were capable of binding one or multiple A2, A3, and B7 supertype molecules with affinities typical of viral determinants. Surprisingly, many of the viral proteins recognized are predicted to be late gene products, in addition to the early intermediate gene products expected. Nearly all of the determinants identified have identical counterparts encoded by modified vaccinia virus Ankara as well as variola virus, the agent of smallpox. These findings have implications for the design of new smallpox vaccines and the understanding of immune responses to large DNA viruses in general. JF - Journal of Immunology AU - Pasquetto, Valerie AU - Bui, Huynh-Hoa AU - Giannino, Rielle AU - Mirza, Fareed AU - Sidney, John AU - Oseroff, Carla AU - Tscharke, David C AU - Irvine, Kari AU - Bennink, Jack R AU - Peters, Bjoern AU - Southwood, Scott AU - Cerundolo, Vincenzo AU - Grey, Howard AU - Yewdell, Jonathan W AU - Sette, Alessandro AD - La Jolla Institute for Allergy and Immunology, San Diego, CA 92109. Tumor Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford, United Kingdom. Epimmune Incorporated, San Diego, CA 92121. Laboratory of Viral Diseases, National Institutes of Health, Bethesda, MD 20892. Division of Immunology and Infectious Diseases, Queensland Institute of Medical Research, Herston, Queensland, Australia Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 5504 EP - 5515 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 175 IS - 8 SN - 0022-1767, 0022-1767 KW - smallpox virus KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Genomes KW - Histocompatibility antigen HLA KW - Vaccinia KW - Algorithms KW - RNA viruses KW - CD8 antigen KW - Transgenic mice KW - Computer applications KW - DNA viruses KW - B7 antigen KW - Smallpox KW - Cytotoxicity KW - Vaccinia virus KW - Poxvirus KW - Antigenic determinants KW - Lymphocytes T KW - Vaccines KW - Immune response KW - Variola virus KW - V 22099:Immune response & immune mechanisms KW - F 06100:Vaccines - active immunity KW - G 07730:Development & Cell Cycle KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19818419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=HLA-A*0201%2C+HLA-A*1101%2C+and+HLA-B*0702+Transgenic+Mice+Recognize+Numerous+Poxvirus+Determinants+from+a+Wide+Variety+of+Viral+Gene+Products&rft.au=Pasquetto%2C+Valerie%3BBui%2C+Huynh-Hoa%3BGiannino%2C+Rielle%3BMirza%2C+Fareed%3BSidney%2C+John%3BOseroff%2C+Carla%3BTscharke%2C+David+C%3BIrvine%2C+Kari%3BBennink%2C+Jack+R%3BPeters%2C+Bjoern%3BSouthwood%2C+Scott%3BCerundolo%2C+Vincenzo%3BGrey%2C+Howard%3BYewdell%2C+Jonathan+W%3BSette%2C+Alessandro&rft.aulast=Pasquetto&rft.aufirst=Valerie&rft.date=2005-10-01&rft.volume=175&rft.issue=8&rft.spage=5504&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-01-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Genomes; Vaccinia; Algorithms; RNA viruses; CD8 antigen; Computer applications; Transgenic mice; DNA viruses; B7 antigen; Smallpox; Cytotoxicity; Antigenic determinants; Lymphocytes T; Immune response; Vaccines; Vaccinia virus; Poxvirus; Variola virus ER - TY - JOUR T1 - Unravelling the structure of the pneumococcal autolytic lysozyme AN - 19792538; 7195779 AB - The LytC lysozyme of Streptococcus pneumoniae forms part of the autolytic system of this important pathogen. This enzyme is composed of a C-terminal CM (catalytic module), belonging to the GH25 family of glycosyl hydrolases, and an N-terminal CBM (choline-binding module), made of eleven homologous repeats, that specifically recognizes the choline residues that are present in pneumococcal teichoic and lipoteichoic acids. This arrangement inverts the general assembly pattern of the major pneumococcal autolysin, LytA, and the lytic enzymes encoded by pneumococcal bacteriophages that place the CBM (made of six repeats) at the C-terminus. In the present paper, a three-dimensional model of LytC built by homology modelling of each module and consistent with spectroscopic and hydrodynamic studies is shown. In addition, the putative catalytic-pair residues are identified. Despite the inversion in the modular arrangement, LytC and the bacteriophage-encoded Cpl-1 lysozyme most probably adopt a similar global fold. However, the distinct choline-binding ability and their substrate-binding surfaces may reflect a divergent evolution directed by the different roles played by them in the host (LytC) or in the bacteriophage (Cpl-1). The tight binding of LytC to the pneumococcal envelope, mediated by the acquisition of additional choline-binding repeats, could facilitate the regulation of the potentially suicidal activity of this autolysin. In contrast, a looser attachment of Cpl-1 to the cell wall and the establishment of more favourable interactions between its highly negatively charged catalytic surface and the positively charged chains of pneumococcal murein could enhance the lytic activity of the parasite-encoded enzyme and therefore liberation of the phage progeny. JF - Biochemical Journal AU - Monterroso, B AU - Lopez-Zumel, C AU - Garcia, J L AU - Salz, J L AU - Garcia, P AU - Campillo, N E AU - Menendez, M AD - Section on Physical Biochemistry, Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA, nuria@suricata.iqm.csic.es Y1 - 2005/10/01/ PY - 2005 DA - 2005 Oct 01 SP - 41 EP - 49 VL - 391 IS - 1 SN - 0264-6021, 0264-6021 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology KW - Phages KW - Lysozyme KW - Choline KW - Murein KW - Hydrodynamics KW - C-Terminus KW - Enzymes KW - Pathogens KW - Lipoteichoic acid KW - Lytic enzymes KW - Autolysins KW - Streptococcus pneumoniae KW - Envelopes KW - Homology KW - Inversion KW - Glycosyl hydrolase KW - Progeny KW - Evolution KW - Cell walls KW - V 22320:Replication KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19792538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+Journal&rft.atitle=Unravelling+the+structure+of+the+pneumococcal+autolytic+lysozyme&rft.au=Monterroso%2C+B%3BLopez-Zumel%2C+C%3BGarcia%2C+J+L%3BSalz%2C+J+L%3BGarcia%2C+P%3BCampillo%2C+N+E%3BMenendez%2C+M&rft.aulast=Monterroso&rft.aufirst=B&rft.date=2005-10-01&rft.volume=391&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Biochemical+Journal&rft.issn=02646021&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Phages; Lysozyme; Choline; Murein; Hydrodynamics; C-Terminus; Enzymes; Pathogens; Lytic enzymes; Lipoteichoic acid; Autolysins; Envelopes; Homology; Inversion; Progeny; Glycosyl hydrolase; Evolution; Cell walls; Streptococcus pneumoniae ER - TY - JOUR T1 - An assessment of hepatitis C virus infection among health-care workers of the National Cancer Institute of Naples, Southern Italy AN - 19774150; 6734928 AB - As many people with chronic hepatitis C virus (HCV) infection are asymptomatic, HCV infection could spread easily among the health-care workers of the National Cancer Institute of Naples (especially before the identification of HCV and in the absence of good, effective preventative measures, e.g. sterile syringe use, gloves, protective glasses). In order to determine whether there is a transmission risk for HCV infection from patient to health-care worker, we carried out a cross-sectional study of a cohort of National Cancer Institute health-care workers in Naples, Southern Italy. The chi super(2)-test was not significant; we did not find any significant risk for HCV in the 'other untrained staff group [odds ratio (OR) 2.2; 95% confidence interval (CI) 0.4-10.9] or in the health-care workers group (OR 1.6; 95% CI 0.4-7.0). In the health-care worker subgroups, doctors were the reference category because of the low prevalence of HCV in this subgroup (3.3%). A non-significant association was found in the professional nurses group (OR 2.7; 95% CI 0.8-8.8), as well as in the categories of technicians and biologists. No excessive risk was found among the health-care workers as a whole or among the different categories of personnel, confirming that health-care employees have benefited sufficiently from preventative measures. JF - European Journal of Public Health AU - Montella, M AU - Crispo, A AU - Grimaldi, M AU - Ruffolo, P AU - Ronga, D AU - Izzo, F AU - Mastro, A A AD - Epidemiology Unit, National Cancer Institute, Via Mariano Semmola, 80131 Naples, Italy, epidemiologia.int@tin.it Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 467 EP - 469 VL - 15 IS - 5 SN - 1101-1262, 1101-1262 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - needles KW - Medical personnel KW - Public health KW - Protective clothing KW - Prevention KW - Hepatitis C virus KW - Personnel KW - Italy, Naples KW - Chronic infection KW - Gloves KW - Syringes KW - Hepatitis C KW - Occupational exposure KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19774150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Public+Health&rft.atitle=An+assessment+of+hepatitis+C+virus+infection+among+health-care+workers+of+the+National+Cancer+Institute+of+Naples%2C+Southern+Italy&rft.au=Montella%2C+M%3BCrispo%2C+A%3BGrimaldi%2C+M%3BRuffolo%2C+P%3BRonga%2C+D%3BIzzo%2C+F%3BMastro%2C+A+A&rft.aulast=Montella&rft.aufirst=M&rft.date=2005-10-01&rft.volume=15&rft.issue=5&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Public+Health&rft.issn=11011262&rft_id=info:doi/10.1093%2Feurpub%2Fcki032 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Personnel; Chronic infection; Syringes; Gloves; Public health; Prevention; Protective clothing; needles; Hepatitis C; Occupational exposure; Medical personnel; Hepatitis C virus; Italy, Naples DO - http://dx.doi.org/10.1093/eurpub/cki032 ER - TY - JOUR T1 - Monitoring Differentiation of Human Embryonic Stem Cells Using Real-Time PCR AN - 19772258; 7145383 AB - There is a general lack of rapid, sensitive, and quantitative methods for the detection of differentiating human embryonic stem cells (hESCs). Using light microscopy and immunohistochemistry, we observed that morphological changes of differentiating hESCs precede any major alterations in the expression of several commonly used hESC markers (SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, Oct-4, and Nanog). In an attempt to quantify the changes during stochastic differentiation of hESCs, we developed a robust and sensitive multi-marker quantitative real-time polymerase chain reaction (QPCR) method. To maximize the sensitivity of the method, we measured the expression of up- and downregulated genes before and after differentiation of the hESCs. Out of the 12 genes assayed, we found it clearly sufficient to determine the relative differentiation state of the cells by calculating a collective expression index based on the mRNA levels of Oct-4, Nanog, Cripto, and alpha -fetoprotein. We evaluated the method using different hESC lines maintained in either feeder-dependent or feeder-free culture conditions. The QPCR method is very flexible, and by appropriately selecting reporter genes, the method can be designed for various applications. The combination of QPCR with hESC-based technologies opens novel avenues for high-throughput analysis of hESCs in, for example, pharmacological and cytotoxicity screening. JF - Stem Cells AU - Noaksson, Karin AU - Zoric, Neven AU - Zeng, Xianmin AU - Rao, Mahendra S AU - Hyllner, Johan AU - Semb, Henrik AU - Kubista, Mikael AU - Sartipy, Peter AD - Cellartis AB, Goeteborg, Sweden. TATAA Biocenter, Lundberg Laboratory, Goeteborg, Sweden. Cellular Neurobiology Branch, National Institute on Drug Abuse, Department of Health and Human Services, Baltimore, Maryland, USA. Laboratory of Neurosciences, National Institute of Aging, Department of Health and Human Services, Baltimore, Maryland, USA. Section of Endocrinology, Lund University, Lund, Sweden Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 1460 EP - 1467 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 23 IS - 10 SN - 1066-5099, 1066-5099 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Differentiation KW - Stem cells KW - Cytotoxicity KW - Embryo cells KW - alpha -fetoprotein KW - Polymerase chain reaction KW - Cell culture KW - Oct-4 protein KW - Immunohistochemistry KW - Stochasticity KW - mRNA KW - G 07720:Immunogenetics KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19772258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Monitoring+Differentiation+of+Human+Embryonic+Stem+Cells+Using+Real-Time+PCR&rft.au=Noaksson%2C+Karin%3BZoric%2C+Neven%3BZeng%2C+Xianmin%3BRao%2C+Mahendra+S%3BHyllner%2C+Johan%3BSemb%2C+Henrik%3BKubista%2C+Mikael%3BSartipy%2C+Peter&rft.aulast=Noaksson&rft.aufirst=Karin&rft.date=2005-10-01&rft.volume=23&rft.issue=10&rft.spage=1460&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Differentiation; Cytotoxicity; Stem cells; Embryo cells; alpha -fetoprotein; Polymerase chain reaction; Cell culture; Oct-4 protein; Stochasticity; Immunohistochemistry; mRNA ER - TY - JOUR T1 - Expression of human peripheral cannabinoid receptor for structural studies AN - 19766983; 6508261 AB - Human peripheral-type cannabinoid receptor (CB2) was expressed in Escherichia coli as a fusion with the maltose-binding protein, thioredoxin, and a deca-histidine tag. Functional activity and structural integrity of the receptor in bacterial protoplast membranes was confirmed by extensive binding studies with a variety of natural and synthetic cannabinoid ligands. E. coli membranes expressing CB2 also activated cognate G-proteins in an in vitro coupled assay. Detergent-solubilized receptor was purified to 80%-90% homogeneity by affinity chromatography followed by ion-exchange chromatography. By high-resolution NMR on the receptor in DPC micelles, it was determined that purified CB2 forms 1:1 complexes with the ligands CP-55,940 and anandamide. The receptor was successfully reconstituted into phosphatidylcholine bilayers and the membranes were deposited into a porous substrate as tubular lipid bilayers for structural studies by NMR and scattering techniques. JF - Protein Science AU - Yeliseev, Alexei A AU - Wong, Karen K AU - Soubias, Olivier AU - Gawrisch, Klaus AD - Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 2638 EP - 2653 PB - Cold Spring Harbor Laboratory Press, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 14 IS - 10 SN - 0961-8368, 0961-8368 KW - Microbiology Abstracts B: Bacteriology KW - Thioredoxin KW - Lipid bilayers KW - Anandamide KW - Ion-exchange chromatography KW - Lecithin KW - Guanine nucleotide-binding protein KW - Affinity chromatography KW - Micelles KW - Structure-function relationships KW - Cannabinoid CB2 receptors KW - Escherichia coli KW - Protoplasts KW - N.M.R. KW - maltose-binding protein KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19766983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Science&rft.atitle=Expression+of+human+peripheral+cannabinoid+receptor+for+structural+studies&rft.au=Yeliseev%2C+Alexei+A%3BWong%2C+Karen+K%3BSoubias%2C+Olivier%3BGawrisch%2C+Klaus&rft.aulast=Yeliseev&rft.aufirst=Alexei&rft.date=2005-10-01&rft.volume=14&rft.issue=10&rft.spage=2638&rft.isbn=&rft.btitle=&rft.title=Protein+Science&rft.issn=09618368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Thioredoxin; Lipid bilayers; Anandamide; Lecithin; Ion-exchange chromatography; Guanine nucleotide-binding protein; Affinity chromatography; Structure-function relationships; Micelles; Cannabinoid CB2 receptors; Protoplasts; N.M.R.; maltose-binding protein; Escherichia coli ER - TY - JOUR T1 - Nuclear Magnetic Resonance Solution Structure of the Escherichia coli DNA Polymerase III theta Subunit AN - 19762664; 6503228 AB - The catalytic core of Escherichia coli DNA polymerase III holoenzyme contains three subunits: alpha , epsilon , and theta . The alpha subunit contains the polymerase, and the epsilon subunit contains the exonucleolytic proofreading function. The small (8-kDa) theta subunit binds only to epsilon . Its function is not well understood, although it was shown to exert a small stabilizing effect on the epsilon proofreading function. In order to help elucidate its function, we undertook a determination of its solution structure. In aqueous solution, theta yielded poor-quality nuclear magnetic resonance spectra, presumably due to conformational exchange and/or protein aggregation. Based on our recently determined structure of the theta homolog from bacteriophage P1, named HOT, we constructed a homology model of theta . This model suggested that the unfavorable behavior of theta might arise from exposed hydrophobic residues, particularly toward the end of alpha -helix 3. In gel filtration studies, theta elutes later than expected, indicating that aggregation is potentially responsible for these problems. To address this issue, we recorded super(1)H- super(15)N heteronuclear single quantum correlation (HSQC) spectra in water-alcohol mixed solvents and observed substantially improved dispersion and uniformity of peak intensities, facilitating a structural determination under these conditions. The structure of theta in 60/40 (vol/vol) water-methanol is similar to that of HOT but differs significantly from a previously reported theta structure. The new theta structure is expected to provide additional insight into its physiological role and its effect on the epsilon proofreading subunit. JF - Journal of Bacteriology AU - Mueller, Geoffrey A AU - Kirby, Thomas W AU - DeRose, Eugene F AU - Li, Dawei AU - Schaaper, Roel M AU - London, Robert E AD - Laboratory of Structural Biology. Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Box 12233, Research Triangle Park, North Carolina 27709 Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 7081 EP - 7089 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 187 IS - 20 SN - 0021-9193, 0021-9193 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Phages KW - Filtration KW - Homology KW - DNA-directed DNA polymerase KW - Escherichia coli KW - Solvents KW - N.M.R. KW - Hydrophobicity KW - Protein interaction KW - Proofreading KW - Models KW - J 02725:DNA KW - N 14085:DNA: Transcription factors, repressors, nucleoproteins & DNA-binding proteins KW - V 22320:Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19762664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Nuclear+Magnetic+Resonance+Solution+Structure+of+the+Escherichia+coli+DNA+Polymerase+III+theta+Subunit&rft.au=Mueller%2C+Geoffrey+A%3BKirby%2C+Thomas+W%3BDeRose%2C+Eugene+F%3BLi%2C+Dawei%3BSchaaper%2C+Roel+M%3BLondon%2C+Robert+E&rft.aulast=Mueller&rft.aufirst=Geoffrey&rft.date=2005-10-01&rft.volume=187&rft.issue=20&rft.spage=7081&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Phages; Filtration; Homology; DNA-directed DNA polymerase; Solvents; Hydrophobicity; N.M.R.; Protein interaction; Models; Proofreading; Escherichia coli ER - TY - JOUR T1 - Enduring representational plasticity after somatosensory stimulation AN - 19437509; 6676548 AB - Somatosensory stimulation (SS), leading to increases in motor cortical excitability, influences motor performance in patients with brain lesions like stroke. The mechanisms by which SS modulates motor function are incompletely understood. Here, we used functional magnetic resonance imaging (fMRI, blood- oxygenation-level-dependent (BOLD), and perfusion imagings simultaneously acquired in a 3 T magnet) to assess the effects of SS on thumb-movement-related activation in three regions of interest (ROI) in the motor network: primary motor cortex (M1), primary somatosensory cortex (S1), and dorsal premotor cortex (PMd) in healthy volunteers. Scans were obtained in different sessions before and after 2-h electrical stimulation applied to the median nerve at the wrist (MNS), to the skin overlying the shoulder deltoid muscle (DMS), and in the absence of stimulation (NOSTIM) in a counterbalanced design. We found that baseline perfusion intensity was comparable within and across sessions. MNS but not DMS nor NOSTIM led to an increase in signal intensity and number of voxels activated by performance of median nerve-innervated thumb movements in M1, S1, and PMd for up to 60 min. Task-related fMRI activation changes were most prominent in M1 followed by S1 and to a lesser extent in PMd. MNS elicited a displacement of the center of gravity for the thumb movement representation towards the other finger representations within S1. These results indicate that MNS leads to an expansion of the thumb representation towards other finger representations within S1, a form of plasticity that may underlie the influence of SS on motor cortical function, possibly supporting beneficial effects on motor control. JF - NeuroImage AU - Wu, Carolyn W-H AU - Van Gelderen, Peter AU - Hanakawa, Takashi AU - Yaseen, Zaneb AU - Cohen, Leonardo G AD - Human Cortical Physiology Section, NINDS, NIH, Bethesda, MD 20892, USA, wuwh@ninds.nih.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 872 EP - 884 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 27 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Neuroimaging KW - Functional magnetic resonance imaging KW - Wrist KW - Excitability KW - Electrical stimuli KW - Cortex KW - Cortex (premotor) KW - Shoulder KW - Cortex (motor) KW - Perfusion KW - Skin KW - median nerve KW - Plasticity (cortical) KW - Stroke KW - Motor task performance KW - Muscles KW - Brain KW - Finger KW - Cortex (somatosensory) KW - W 30910:Imaging KW - N3 11004:Motor & sensory systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19437509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Enduring+representational+plasticity+after+somatosensory+stimulation&rft.au=Wu%2C+Carolyn+W-H%3BVan+Gelderen%2C+Peter%3BHanakawa%2C+Takashi%3BYaseen%2C+Zaneb%3BCohen%2C+Leonardo+G&rft.aulast=Wu&rft.aufirst=Carolyn&rft.date=2005-10-01&rft.volume=27&rft.issue=4&rft.spage=872&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2005.05.055ZZ%3A LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Functional magnetic resonance imaging; Cortex (somatosensory); Finger; Cortex (premotor); Motor task performance; Cortex (motor); Neuroimaging; Stroke; Shoulder; Wrist; Plasticity (cortical); Excitability; median nerve; Electrical stimuli; Brain; Muscles; Skin; Cortex; Perfusion DO - http://dx.doi.org/10.1016/j.neuroimage.2005.05.055ZZ: ER - TY - JOUR T1 - High-resolution cDNA microarray-based comparative genomic hybridization analysis in neuroblastoma AN - 19418528; 6676642 AB - Neuroblastoma (NB) is one of the most common pediatric solid tumors and displays a broad variety of genomic alterations. Array-based comparative genomic hybridization (A-CGH) is a novel technology enabling the high-resolution detection of DNA copy number aberrations. In this article, we outline features of this new technology and approaches of data analysis. We focus on stage specific DNA copy number variations in neuroblastoma detected by cDNA array- based comparative genomic hybridization (A-CGH). We also discuss hypothetic evolutionary models of neuroblastoma progression that can be derived from A-CGH data. JF - Cancer Letters AU - Chen, Qing-Rong AU - Bilke, Sven AU - Khan, Javed AD - Oncogenomics Section, Pediatric Oncology Branch, Advanced Technology Center, National Cancer Institute, 8717 Government Circle, Gaithersburg, MD 20877, USA, chenqi@mail.nih.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 71 EP - 81 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 228 IS - 1-2 SN - 0304-3835, 0304-3835 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Neuroblastoma KW - Array CGH KW - Microarray KW - Tumor evolution KW - DNA copy number KW - Genomic alteration KW - Amplification KW - MYCN KW - Data processing KW - Pediatrics KW - Solid tumors KW - DNA KW - genomics KW - DNA microarrays KW - Evolution KW - Hybridization analysis KW - copy number KW - W 30900:Methods KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19418528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Letters&rft.atitle=High-resolution+cDNA+microarray-based+comparative+genomic+hybridization+analysis+in+neuroblastoma&rft.au=Chen%2C+Qing-Rong%3BBilke%2C+Sven%3BKhan%2C+Javed&rft.aulast=Chen&rft.aufirst=Qing-Rong&rft.date=2005-10-01&rft.volume=228&rft.issue=1-2&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Cancer+Letters&rft.issn=03043835&rft_id=info:doi/10.1016%2Fj.canlet.2004.12.056 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Data processing; Solid tumors; Pediatrics; DNA; genomics; DNA microarrays; Hybridization analysis; Evolution; Neuroblastoma; copy number DO - http://dx.doi.org/10.1016/j.canlet.2004.12.056 ER - TY - JOUR T1 - Recovery of Stem Cells from Cryopreserved Periodontal Ligament AN - 19418044; 6492151 AB - Human post-natal stem cells possess a great potential to be utilized in stem-cell-mediated clinical therapies and tissue engineering. It is not known whether cryopreserved human tissues contain functional post-natal stem cells. In this study, we utilized human periodontal ligament to test the hypothesis that cryopreserved human periodontal ligament contains retrievable post-natal stem cells. These cryopreserved periodontal ligament stem cells maintained normal periodontal ligament stem cell characteristics, including expression of the mesenchymal stem cell surface molecule STRO-1, single-colony-strain generation, multipotential differentiation, cementum/periodontal-ligament-like tissue regeneration, and a normal diploid karyotype. Collectively, this study provides valuable evidence demonstrating a practical approach to the preservation of solid-frozen human tissues for subsequent post-natal stem cell isolation and tissue regeneration. The present study demonstrates that human post-natal stem cells can be recovered from cryopreserved human periodontal ligament, thereby providing a practical clinical approach for the utilization of frozen tissues for stem cell isolation. JF - Journal of Dental Research AU - Seo, B-M AU - Miura, M AU - Sonoyama, W AU - Coppe, C AU - Stanyon, R AU - Shi, S AD - Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, Building 30, Room 131, 30 Convent Drive MSC-4320, and Comparative Molecular Cytogenetics Core, Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, sshi@dir.nidcr.nih.gov Y1 - 2005/10/01/ PY - 2005 DA - 2005 Oct 01 SP - 907 EP - 912 VL - 84 IS - 10 SN - 0022-0345, 0022-0345 KW - Biotechnology and Bioengineering Abstracts KW - Differentiation KW - Cell surface KW - Stem cells KW - Diploids KW - periodontal ligament KW - Cementum KW - Preservation KW - Tissue engineering KW - Mesenchyme KW - Karyotypes KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19418044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Dental+Research&rft.atitle=Recovery+of+Stem+Cells+from+Cryopreserved+Periodontal+Ligament&rft.au=Seo%2C+B-M%3BMiura%2C+M%3BSonoyama%2C+W%3BCoppe%2C+C%3BStanyon%2C+R%3BShi%2C+S&rft.aulast=Seo&rft.aufirst=B-M&rft.date=2005-10-01&rft.volume=84&rft.issue=10&rft.spage=907&rft.isbn=&rft.btitle=&rft.title=Journal+of+Dental+Research&rft.issn=00220345&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Stem cells; periodontal ligament; Cell surface; Mesenchyme; Tissue engineering; Cementum; Karyotypes; Differentiation; Diploids; Preservation ER - TY - JOUR T1 - SNPdetector: A Software Tool for Sensitive and Accurate SNP Detection AN - 19417191; 6514396 AB - Identification of single nucleotide polymorphisms (SNPs) and mutations is important for the discovery of genetic predisposition to complex diseases. PCR resequencing is the method of choice for de novo SNP discovery. However, manual curation of putative SNPs has been a major bottleneck in the application of this method to high-throughput screening. Therefore it is critical to develop a more sensitive and accurate computational method for automated SNP detection. We developed a software tool, SNPdetector, for automated identification of SNPs and mutations in fluorescence-based resequencing reads. SNPdetector was designed to model the process of human visual inspection and has a very low false positive and false negative rate. We demonstrate the superior performance of SNPdetector in SNP and mutation analysis by comparing its results with those derived by human inspection, PolyPhred (a popular SNP detection tool), and independent genotype assays in three large-scale investigations. The first study identified and validated inter- and intra-subspecies variations in 4,650 traces of 25 inbred mouse strains that belong to either the Mus musculus species or the M. spretus species. Unexpected heterozgyosity in CAST/Ei strain was observed in two out of 1,167 mouse SNPs. The second study identified 11,241 candidate SNPs in five ENCODE regions of the human genome covering 2.5 Mb of genomic sequence. Approximately 50% of the candidate SNPs were selected for experimental genotyping; the validation rate exceeded 95%. The third study detected ENU- induced mutations (at 0.04% allele frequency) in 64,896 traces of 1,236 zebra fish. Our analysis of three large and diverse test datasets demonstrated that SNPdetector is an effective tool for genome-scale research and for large-sample clinical studies. SNPdetector runs on Unix/Linux platform and is available publicly (http://lpg.nci.nih.gov JF - PLoS Computational Biology AU - Zhang, Jinghui AU - Wheeler, David A AU - Yakub, Imtiaz AU - Wei, Sharon AU - Sood, Raman AU - Rowe, William AU - Liu, Paul P AU - Gibbs, Richard A AU - Buetow, Kenneth H AD - Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America, jinghuiz@mail.nih.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 PB - Public Library of Science, 185 Berry Street Suite 1300 San Francisco CA 94107 USA, [mailto:plos@plos.org], [URL:http://www.plos.org] VL - 1 IS - 5 SN - 1553-734X, 1553-734X KW - Biotechnology and Bioengineering Abstracts KW - Genomes KW - Nucleotide sequence KW - Genotyping KW - Animal models KW - Computer applications KW - Mus musculus KW - Models KW - Computer programs KW - Danio rerio KW - software KW - Single-nucleotide polymorphism KW - Polymerase chain reaction KW - high-throughput screening KW - genomics KW - Mutation KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19417191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Computational+Biology&rft.atitle=SNPdetector%3A+A+Software+Tool+for+Sensitive+and+Accurate+SNP+Detection&rft.au=Zhang%2C+Jinghui%3BWheeler%2C+David+A%3BYakub%2C+Imtiaz%3BWei%2C+Sharon%3BSood%2C+Raman%3BRowe%2C+William%3BLiu%2C+Paul+P%3BGibbs%2C+Richard+A%3BBuetow%2C+Kenneth+H&rft.aulast=Zhang&rft.aufirst=Jinghui&rft.date=2005-10-01&rft.volume=1&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Computational+Biology&rft.issn=1553734X&rft_id=info:doi/10.1371%2Fjournal.pcbi.0010053 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Danio rerio; Mus musculus; Single-nucleotide polymorphism; Mutation; Computer programs; software; Computer applications; genomics; Genotyping; Models; Animal models; Genomes; Nucleotide sequence; high-throughput screening; Polymerase chain reaction DO - http://dx.doi.org/10.1371/journal.pcbi.0010053 ER - TY - JOUR T1 - ORIOGEN: order restricted inference for ordered gene expression data AN - 19414738; 6509121 AB - SUMMARY: ORIOGEN is a user-friendly Java-based software package for selecting and clustering genes according to their profiles across various treatment groups. In particular, ORIOGEN is useful for analyzing data obtained from time-course or dose-response type experiments. AVAILABILITY: The ORIOGEN software can be downloaded freely from http://dir.niehs.nih.gov/dirbb/oriogen/index.cfm. Supplementary information: ORIOGEN has a full set of help files. Also, an example input file is provided with the download. JF - Bioinformatics AU - Peddada, S AU - Harris, S AU - Zajd, J AU - Harvey, E AD - Biostatistics Branch, National Institute of Environmental Health Sciences Durham, NC 27713, USA. Constella Group, LLC Durham, NC 27713, USA, peddada@niehs.nih.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 3933 EP - 3934 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 21 IS - 20 SN - 1367-4803, 1367-4803 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Computer programs KW - software KW - Data processing KW - Statistics KW - Bioinformatics KW - G 07880:Human Genetics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19414738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=ORIOGEN%3A+order+restricted+inference+for+ordered+gene+expression+data&rft.au=Peddada%2C+S%3BHarris%2C+S%3BZajd%2C+J%3BHarvey%2C+E&rft.aulast=Peddada&rft.aufirst=S&rft.date=2005-10-01&rft.volume=21&rft.issue=20&rft.spage=3933&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gene expression; Computer programs; software; Statistics; Data processing; Bioinformatics ER - TY - JOUR T1 - Robust accurate identification of peptides (RAId): deciphering MS super(2) data using a structured library search with de novo based statistics AN - 19413408; 6509088 AB - MOTIVATION: The key to MS -based proteomics is peptide sequencing. The major challenge in peptide sequencing, whether library search or de novo, is to better infer statistical significance and better attain noise reduction. Since the noise in a spectrum depends on experimental conditions, the instrument used and many other factors, it cannot be predicted even if the peptide sequence is known. The characteristics of the noise can only be uncovered once a spectrum is given. We wish to overcome such issues. RESULTS: We designed RAId to identify peptides from their associated tandem mass spectrometry data. RAId performs a novel de novo sequencing followed by a search in a peptide library that we created. Through de novo sequencing, we establish the spectrum-specific background score statistics for the library search. When the database search fails to return significant hits, the top-ranking de novo sequences become potential candidates for new peptides that are not yet in the database. The use of spectrum-specific background statistics seems to enable RAId to perform well even when the spectral quality is marginal. Other important features of RAId include its potential in de novo sequencing alone and the ease of incorporating post-translational modifications. AVAILABILITY: Programs implementing the methods described are available from the authors on request. CONTACT: yyucbi.nlm.nih.gov Supplementary information: ftp://ftp.ncbi.nih.gov/pub/yyu/Proteomics/MSMS/RAId/MSMS_bioinfo_s u pp.pdf JF - Bioinformatics AU - Alves, Gelio AU - Yu, Yi-Kuo AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health Bethesda, MD 20894, USA Y1 - 2005/10/01/ PY - 2005 DA - 2005 Oct 01 SP - 3726 EP - 3732 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 21 IS - 19 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - Databases KW - Statistics KW - Post-translation KW - Bioinformatics KW - proteomics KW - Peptide libraries KW - Mass spectroscopy KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19413408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Robust+accurate+identification+of+peptides+%28RAId%29%3A+deciphering+MS+super%282%29+data+using+a+structured+library+search+with+de+novo+based+statistics&rft.au=Alves%2C+Gelio%3BYu%2C+Yi-Kuo&rft.aulast=Alves&rft.aufirst=Gelio&rft.date=2005-10-01&rft.volume=21&rft.issue=19&rft.spage=3726&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Statistics; proteomics; Databases; Peptide libraries; Mass spectroscopy; Post-translation; Computer programs; Bioinformatics ER - TY - JOUR T1 - Immunoassay Interference by a Commonly Used Blood Collection Tube Additive, the Organosilicone Surfactant Silwet L-720 AN - 19412133; 6502826 AB - BACKGROUND: A small number of immunoassays on several different types of analyzers were recently adversely affected by tube additives in Becton Dickinson (BD) Vacutainer registered SST super(TM), SST II, and Microtainer super(TM) blood collection tubes. We examined the effect of a commonly used tube surfactant, Silwet super(TM) L-720, on immunoassays and the mechanism for the interference. METHODS: Immunoassays were performed on serum supplemented with Silwet L-720 on the IMMULITE super(TM) 2500 and AxSYM super(TM) analyzers. Direct effects of the surfactant on the chemiluminescent detection step of immunoassays and on antibody immobilization on the solid phase were examined. RESULTS: Increasing the final surfactant concentration from 0 to 400 mg/L in serum significantly increased ( similar to 51%) the apparent total triiodothyronine (TT sub(3)) concentrations measured on the IMMULITE 2500 but not the AxSYM analyzer. Several other competitive, but not noncompetitive, assays were also significantly affected by the surfactant on the IMMULITE 2500 analyzer. The effect was independent of serum components, and the surfactant had no direct effect on chemiluminescence reactions. The capture antibody, however, was displaced from the solid phase by incubation with solutions containing surfactant under conditions similar to the IMMULITE TT sub(3) assay. CONCLUSIONS: The Silwet L-720 surfactant, which is used to coat the inner surfaces of tubes, appears to account for previously reported immunoassay interference by BD Vacutainer SST blood collection tubes. One of the mechanisms for the interference is the desorption of antibodies from the solid phase by the surfactant. The results identify an important factor in the selection of suitable blood collection tube surfactants and provide an approach for solving similar tube-assay interference problems in the future. JF - Clinical Chemistry AU - Bowen, Raffick AR AU - Chan, Yung AU - Ruddel, Mark E AU - Hortin, Glen L AU - Csako, Gyorgy AU - Demosky, Stephen JJr AU - Remaley, Alan T AD - Department of Laboratory Medicine, Warren Grant Magnuson Clinical Center, and Molecular Disease Section, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 1874 EP - 1882 PB - American Association for Clinical Chemistry, Inc. VL - 51 IS - 10 SN - 0009-9147, 0009-9147 KW - Biotechnology and Bioengineering Abstracts KW - Thyroid hormones KW - Blood KW - Antibodies KW - Desorption KW - Triiodothyronine KW - Chemiluminescence KW - Immunoassays KW - Surfactants KW - Immobilization KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19412133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Chemistry&rft.atitle=Immunoassay+Interference+by+a+Commonly+Used+Blood+Collection+Tube+Additive%2C+the+Organosilicone+Surfactant+Silwet+L-720&rft.au=Bowen%2C+Raffick+AR%3BChan%2C+Yung%3BRuddel%2C+Mark+E%3BHortin%2C+Glen+L%3BCsako%2C+Gyorgy%3BDemosky%2C+Stephen+JJr%3BRemaley%2C+Alan+T&rft.aulast=Bowen&rft.aufirst=Raffick&rft.date=2005-10-01&rft.volume=51&rft.issue=10&rft.spage=1874&rft.isbn=&rft.btitle=&rft.title=Clinical+Chemistry&rft.issn=00099147&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Surfactants; Immunoassays; Blood; Antibodies; Chemiluminescence; Thyroid hormones; Triiodothyronine; Desorption; Immobilization ER - TY - JOUR T1 - Matrigel: Basement membrane matrix with biological activity AN - 19410407; 6501529 AB - The basement membrane extracellular matrix contacts epithelial, endothelial, fat and smooth muscle cells. Because this extracellular matrix is so thin, it had been hard to study its composition, structure, and function. An extract of a tumor was found to contain all of the components present in basement and to be very biologically active. This extract, termed Matrigel, Cultrex, or EHS matrix, promotes cell differentiation, and is used to measure the invasive activity of tumor cells. In vivo, it is used for measuring angiogenic inhibitors and stimulators, to improve graft survival, repair damaged tissues, and increase tumor growth. JF - Seminars in Cancer Biology AU - Kleinman, H K AU - Martin, G R AD - NIDCR, 30/433, 30 Convent Dr. MSC 4370, Bethesda, MD 20892-4370, USA, hkleinman@dir.nidcr.nih.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 378 EP - 386 VL - 15 IS - 5 SN - 1044-579X, 1044-579X KW - Biotechnology and Bioengineering Abstracts KW - Smooth muscle KW - Differentiation KW - Basement membranes KW - Structure-function relationships KW - Extracellular matrix KW - Angiogenesis KW - Tumors KW - Tumor cells KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19410407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+Cancer+Biology&rft.atitle=Matrigel%3A+Basement+membrane+matrix+with+biological+activity&rft.au=Kleinman%2C+H+K%3BMartin%2C+G+R&rft.aulast=Kleinman&rft.aufirst=H&rft.date=2005-10-01&rft.volume=15&rft.issue=5&rft.spage=378&rft.isbn=&rft.btitle=&rft.title=Seminars+in+Cancer+Biology&rft.issn=1044579X&rft_id=info:doi/10.1016%2Fj.semcancer.2005.05.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Tumors; Extracellular matrix; Basement membranes; Tumor cells; Structure-function relationships; Differentiation; Angiogenesis; Smooth muscle DO - http://dx.doi.org/10.1016/j.semcancer.2005.05.004 ER - TY - JOUR T1 - Cnu, a Novel oriC-Binding Protein of Escherichia coli AN - 17663358; 6503219 AB - We have found, using a newly developed genetic method, a protein (named Cnu, for oriC-binding nucleoid-associated) that binds to a specific 26-base-pair sequence (named cnb) in the origin of replication of Escherichia coli, oriC. Cnu is composed of 71 amino acids (8.4 kDa) and shows extensive amino acid identity to a group of proteins belonging to the Hha/YmoA family. Cnu was previously discovered as a protein that, like Hha, complexes with H-NS in vitro. Our in vivo and in vitro assays confirm the results and further suggest that the complex formation with H-NS is involved in Cnu/Hha binding to cnb. Unlike the hns mutants, elimination of either the cnu or hha gene did not disturb the growth rate, origin content, and synchrony of DNA replication initiation of the mutants compared to the wild-type cells. However, the cnu hha double mutant was moderately reduced in origin content. The Cnu/Hha complex with H-NS thus could play a role in optimal activity of oriC. JF - Journal of Bacteriology AU - Kim, Myung Suk AU - Bae, Sung-Hun AU - Yun, Sang Hoon AU - Lee, Hee Jung AU - Ji, Sang Chun AU - Lee, Ji Hyun AU - Srivastava, Preeti AU - Lee, Seol-Hoon AU - Chae, Huiseok AU - Lee, Younghoon AU - Choi, Byong-Seok AU - Chattoraj, Dhruba K AU - Lim, Heon M AD - Department of Biology, School of Biological Sciences and Biotechnology, Chungnam National University, Taejon, 305-764 Korea. Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255. Department of Chemistry, Korea Advanced Institute of Science and Technology, Taejon, 305-701, Korea Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 6998 EP - 7008 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 187 IS - 20 SN - 0021-9193, 0021-9193 KW - Cnu protein KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - J 02725:DNA KW - G 07320:Bacterial genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17663358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Cnu%2C+a+Novel+oriC-Binding+Protein+of+Escherichia+coli&rft.au=Kim%2C+Myung+Suk%3BBae%2C+Sung-Hun%3BYun%2C+Sang+Hoon%3BLee%2C+Hee+Jung%3BJi%2C+Sang+Chun%3BLee%2C+Ji+Hyun%3BSrivastava%2C+Preeti%3BLee%2C+Seol-Hoon%3BChae%2C+Huiseok%3BLee%2C+Younghoon%3BChoi%2C+Byong-Seok%3BChattoraj%2C+Dhruba+K%3BLim%2C+Heon+M&rft.aulast=Kim&rft.aufirst=Myung&rft.date=2005-10-01&rft.volume=187&rft.issue=20&rft.spage=6998&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-12-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Factors associated with bicycle helmet use among young adolescents in a multinational sample AN - 17660447; 6508890 AB - OBJECTIVE: To determine factors associated with variation in bicycle helmet use by youth of different industrialized countries. DESIGN: A multinational cross sectional nationally representative survey of health behaviors including symptoms, risk taking, school setting, and family context. SETTING: School based survey of 26 countries. SUBJECTS: School students, ages 11, 13, and 15 years totaling 112 843. OUTCOME MEASURES: Reported frequency of bicycle helmet use among bicycle riders. RESULTS: Reported helmet use varied greatly by country from 39.2% to 1.9%, with 12 countries reporting less than 10% of the bicycle riders as frequent helmet users and 14 countries more than 10%. Reported helmet use was highest at 11 years and decreased as children's age increased. Use was positively associated with other healthy behaviors, with parental involvement, and with per capita gross domestic product of the country. It is negatively associated with risk taking behaviors. Countries reported to have interventions promoting helmet use, exemplified by helmet giveaway programmes, had greater frequency of reported helmet use than those without programmes. CONCLUSIONS: Bicycle helmet use among young adolescents varies greatly between countries; however, helmet use does not reach 50% in any country. Age is the most significant individual factor associated with helmet for helmet using countries. The observation that some helmet promotion programmes are reported for countries with relatively higher student helmet use and no programmes reported for the lowest helmet use countries, suggests the possibility of a relation and the need for objective evaluation of programme effectiveness. JF - Injury Prevention AU - Klein, K S AU - Thompson, D AU - Scheidt, P C AU - Overpeck, M D AU - Gross, L A AD - National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 288 EP - 293 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 11 IS - 5 SN - 1353-8047, 1353-8047 KW - Physical Education Index; Health & Safety Science Abstracts KW - H 11000:Diseases/Injuries/Trauma KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17660447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Injury+Prevention&rft.atitle=Factors+associated+with+bicycle+helmet+use+among+young+adolescents+in+a+multinational+sample&rft.au=Klein%2C+K+S%3BThompson%2C+D%3BScheidt%2C+P+C%3BOverpeck%2C+M+D%3BGross%2C+L+A&rft.aulast=Klein&rft.aufirst=K&rft.date=2005-10-01&rft.volume=11&rft.issue=5&rft.spage=288&rft.isbn=&rft.btitle=&rft.title=Injury+Prevention&rft.issn=13538047&rft_id=info:doi/ LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2005-12-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Cancer Mortality among Men Occupationally Exposed to Dichlorodiphenyltrichloroethane AN - 17657043; 6502512 AB - Several studies have evaluated cancer risk associated with occupational and environmental exposure to dichlorodiphenyltrichloroethane (DDT). Results are mixed. To further inquire into human carcinogenicity of DDT, we conducted a mortality follow-up study of 4,552 male workers, exposed to DDT during antimalarial operations in Sardinia, Italy, conducted in 1946 to 1950. Detailed information on DDT use during the operations provided the opportunity to develop individual estimates of average and cumulative exposure. Mortality of the cohort was first compared with that of the Sardinian population. Overall mortality in the cohort was about as expected, but there was a deficit for death from cardiovascular disease and a slight excess for nonmalignant respiratory diseases and lymphatic cancer among the unexposed subcohort. For internal comparisons, we used Poisson regression analysis to calculate relative risks of selected malignant and nonmalignant diseases with the unexposed subcohort as the reference. Cancer mortality was decreased among DDT-exposed workers, mainly due to a reduction in lung cancer deaths. Birth outside from the study area was a strong predictor of mortality from leukemia. Mortality from stomach cancer increased up to 2-fold in the highest quartile of cumulative exposure (relative risk, 2.0; 95% confidence interval, 0.9-4.4), but no exposure-response trend was observed. Risks of liver cancer, pancreatic cancer, and leukemia were not elevated among DDT-exposed workers. No effect of latency on risk estimates was observed over the 45 years of follow-up and within selected time windows. Adjusting risks by possible exposure to chlordane in the second part of the antimalarial operations did not change the results. In conclusion, we found little evidence for a link between occupational exposure to DDT and mortality from any of the cancers previously suggested to be associated. JF - Cancer Research AU - Cocco, Pierluigi AU - Fadda, Domenica AU - Billai, Beatrice AU - D'Atri, Mario AU - Melis, Massimo AU - Blair, Aaron AD - Occupational Health Section, Department of Public Health, University of Cagliari, Cagliari, Italy and Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 9588 EP - 9594 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 65 IS - 20 SN - 0008-5472, 0008-5472 KW - Toxicology Abstracts KW - X 24136:Environmental impact UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17657043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Cancer+Mortality+among+Men+Occupationally+Exposed+to+Dichlorodiphenyltrichloroethane&rft.au=Cocco%2C+Pierluigi%3BFadda%2C+Domenica%3BBillai%2C+Beatrice%3BD%27Atri%2C+Mario%3BMelis%2C+Massimo%3BBlair%2C+Aaron&rft.aulast=Cocco&rft.aufirst=Pierluigi&rft.date=2005-10-01&rft.volume=65&rft.issue=20&rft.spage=9588&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2005-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - An updated catalogue of salivary gland transcripts in the adult female mosquito, Anopheles gambiae AN - 17647012; 6504104 AB - Salivary glands of blood-sucking arthropods contain a variety of compounds that prevent platelet and clotting functions and modify inflammatory and immunological reactions in the vertebrate host. In mosquitoes, only the adult female takes blood meals, while both sexes take sugar meals. With the recent description of the Anopheles gambiae genome, and with a set of similar to 3000 expressed sequence tags from a salivary gland cDNA library from adult female mosquitoes, we attempted a comprehensive description of the salivary transcriptome of this most important vector of malaria transmission. In addition to many transcripts associated with housekeeping functions, we found an active transposable element, a set of Wolbachia-like proteins, several transcription factors, including Forkhead, Hairy and doublesex, extracellular matrix components and 71 genes coding for putative secreted proteins. Fourteen of these 71 proteins had matching Edman degradation sequences obtained from SDS-PAGE experiments. Overall, 33 transcripts are reported for the first time as coding for salivary proteins. The tissue and sex specificity of these protein-coding transcripts were analyzed by RT-PCR and microarray experiments for insight into their possible function. Notably, two gene products appeared to be differentially spliced in the adult female salivary glands, whereas 13 contigs matched predicted intronic regions and may include additional alternatively spliced transcripts. Most An. gambiae salivary proteins represent novel protein families of unknown function, potentially coding for pharmacologically or microbiologically active substances. Supplemental data to this work can be found at http://www.ncbi.nlm.nih.gov/projects/omes/index.html#Ag2. JF - Journal of Experimental Biology AU - Arca, Bruno AU - Lombardo, Fabrizio AU - Valenzuela, Jesus G AU - Francischetti, Ivo MB AU - Marinotti, Osvaldo AU - Coluzzi, Mario AU - Ribeiro, Jose MC AD - Department of Structural and Functional Biology, University "Federico II", 80126 Naples, Italy Parasitology Section, Department of Public Health, University "La Sapienza", 00185 Rome, Italy Medical Entomology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20852, USA Department of Molecular Biology and Biochemistry and Department of Biological Chemistry, University of California, Irvine, CA 92697, USA Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 3971 EP - 3986 PB - Company of Biologists, 140 Cowley Road Cambridge CB4 0DL UK, [URL:http://www.biologists.com/web/index.html] VL - 208 IS - 20 SN - 0022-0949, 0022-0949 KW - Mosquitoes KW - Salivary glands KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Entomology Abstracts KW - Q5 01524:Public health, medicines, dangerous organisms KW - Z 05206:Medical & veterinary entomology KW - Q1 01305:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17647012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Biology&rft.atitle=An+updated+catalogue+of+salivary+gland+transcripts+in+the+adult+female+mosquito%2C+Anopheles+gambiae&rft.au=Arca%2C+Bruno%3BLombardo%2C+Fabrizio%3BValenzuela%2C+Jesus+G%3BFrancischetti%2C+Ivo+MB%3BMarinotti%2C+Osvaldo%3BColuzzi%2C+Mario%3BRibeiro%2C+Jose+MC&rft.aulast=Arca&rft.aufirst=Bruno&rft.date=2005-10-01&rft.volume=208&rft.issue=20&rft.spage=3971&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Biology&rft.issn=00220949&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - The association between stress and drinking: Modifying effects of gender and vulnerability AN - 17597655; 6509958 AB - To assess the relationship between number and type of past-year stressful experiences and alcohol consumption, with a focus on how gender, poverty, and psychological vulnerability moderate this association. Data from 26 946 US past-year drinkers 18 years of age and over, interviewed in the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), were used to construct multivariate linear regression models predicting six measures of drinking pattern and volume. There was a consistent positive relationship between number of past-year Stressors experienced and all measures of heavy drinking. Frequency of heavy (5+ drinks for men; 4+ drinks for women) drinking increased by 24% with each additional Stressor reported by men and by 13% with each additional Stressor reported by women. In contrast, the frequency of moderate drinking (<5 drinks for men; <4 drinks for women) decreased as stress levels increased. Job-related and legal sources of stress were more strongly associated with alcohol consumption than were social and health-related stress. Men showed a stronger association than women between the number of Stressors and the most consumption measures; they also responded more strongly to the presence of any legal and job-related stress. Having an income below the poverty level intensified the effects of job-related stress, but having a mood or anxiety disorder did not affect any of the associations between stress and consumption. Stress does not so much lead individuals to drink more often as to substitute larger quantities of alcohol on the days when they do drink. Treatment and brief interventions aimed at problem drinkers might benefit from addressing the issue of tension alleviation and the development of alternative coping mechanisms. JF - Alcohol and Alcoholism AU - Dawson, DA AU - Grant, B F AU - Ruan, W J AD - NIAAA/LEB Room 3083, 5635 Fishers Lane MSC 9304, Bethesda, MD 20892-9304, USA, ddawson@mail.nih.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 453 EP - 460 VL - 40 IS - 5 SN - 0735-0414, 0735-0414 KW - Risk Abstracts KW - Alcohol KW - Stress KW - Working conditions KW - Gender KW - Substance abuse KW - Occupational health KW - R2 23080:Industrial and labor UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17597655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+and+Alcoholism&rft.atitle=The+association+between+stress+and+drinking%3A+Modifying+effects+of+gender+and+vulnerability&rft.au=Dawson%2C+DA%3BGrant%2C+B+F%3BRuan%2C+W+J&rft.aulast=Dawson&rft.aufirst=DA&rft.date=2005-10-01&rft.volume=40&rft.issue=5&rft.spage=453&rft.isbn=&rft.btitle=&rft.title=Alcohol+and+Alcoholism&rft.issn=07350414&rft_id=info:doi/10.1093%2Falcalc%2Fagh176 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Stress; Alcohol; Substance abuse; Occupational health; Gender; Working conditions DO - http://dx.doi.org/10.1093/alcalc/agh176 ER - TY - JOUR T1 - The potential for gene-targeted radiation therapy of cancers AN - 17589493; 6513230 AB - Targeted cancer therapy is the mantra now chanted by oncologists of all types. Everyone hopes that the rapid expansion in the knowledge of cancer cell genetics, signaling, regulatory factors and other changes that underlie malignant transformation and metastasis will lead to innovative approaches for the treatment of cancers. To date, successful targeted therapies have been derived from pharmaceutical chemistry - designing chemical compounds intended to disrupt a crucial pathway for malignant cells to survive, grow and metastasize. Radiotherapy also has a goal of more-selective targeting of therapeutic radiation effects to only tumor cells. In this review, we describe our efforts to create a form of gene-targeted radiation therapy by using the unique radiation effects of radionuclides that decay by the Auger process attached to oligonucleotide carrier-molecules that are capable of forming triplex DNA structures with target sequences in the genome of the human cancer cell. JF - Trends in Biotechnology AU - Panyutin, I G AU - Neumann, R D Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 492 EP - 496 PB - Elsevier Ltd VL - 23 IS - 10 SN - 0167-7799, 0167-7799 KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Metastases KW - Transformation KW - DNA structure KW - Gene therapy KW - Reviews KW - Radioisotopes KW - Radiotherapy KW - Tumor cells KW - Oligonucleotides KW - Cancer KW - Signal transduction KW - W 30965:Miscellaneous, Reviews KW - W3 33180:Gene based (protocols, clinical trials, and animal models) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17589493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Biotechnology&rft.atitle=The+potential+for+gene-targeted+radiation+therapy+of+cancers&rft.au=Panyutin%2C+I+G%3BNeumann%2C+R+D&rft.aulast=Panyutin&rft.aufirst=I&rft.date=2005-10-01&rft.volume=23&rft.issue=10&rft.spage=492&rft.isbn=&rft.btitle=&rft.title=Trends+in+Biotechnology&rft.issn=01677799&rft_id=info:doi/10.1016%2Fj.tibtech.2005.08.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cancer; Reviews; Oligonucleotides; Gene therapy; Signal transduction; Transformation; DNA structure; Tumor cells; Metastases; Radiotherapy; Radioisotopes DO - http://dx.doi.org/10.1016/j.tibtech.2005.08.001 ER - TY - JOUR T1 - Green fluorescent protein tagging: A novel tool in biomedical research AN - 17425428; 6549508 AB - In recent years, the green fluorescent protein (GFP) isolated from the jellyfish, Aequorea victoria, has become a novel tool in biomedical research. The tagging of GFP to proteins of interest has widely been used in studies involving various biological events both in vitro and in vivo. In this report, the authors demonstrate the utility of GFP tagging for studying localization of protein kinase C (PKC alpha ), and pleckstrin homology (PH) domains of phospholipase C (PLC delta 1), and Akt in mouse neuroblastoma (Neuro 2A) cells. The authors also show the real time translocation of PKC alpha and Akt-PH-EGFP to the membrane upon stimulation with either 12-phorbal myristate acetate (PMA) or insulin growth factor (IGF). Pretreatment of cells expressing PKC alpha -EGFP or Akt-PH-EGFP with staurosporine (a protein kinase inhibitor) or wortmanin (a phosphatidylinositol 3-kinase inhibitor), prevented the translocation of these proteins to the membrane. These data demonstrate that, GFP tagging could be employed as a tool to study sub cellular localization and distribution of signaling proteins in response to external stimuli in real time. JF - Indian Journal of Biotechnology AU - Akbar, M AU - Kim, Hee Yong AD - Section of Mass Spectrometry, Laboratory of Membrane Biochemistry and Biophysics NIAAA, NIH, Rockville, MD 20852, USA, akbarm@exchange.nih.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 466 EP - 470 VL - 4 IS - 4 SN - 0972-5849, 0972-5849 KW - Water jellyfish KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Protein kinase C KW - Phorbol esters KW - Phospholipase C KW - Green fluorescent protein KW - pleckstrin KW - Acetic acid KW - Neuroblastoma KW - Insulin KW - 1-Phosphatidylinositol 3-kinase KW - Staurosporine KW - Insulin-like growth factors KW - AKT protein KW - Aequorea victoria KW - W3 33340:Other proteins, peptides, amino acids KW - W 30965:Miscellaneous, Reviews KW - W3 33250:Methods: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17425428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+Journal+of+Biotechnology&rft.atitle=Green+fluorescent+protein+tagging%3A+A+novel+tool+in+biomedical+research&rft.au=Akbar%2C+M%3BKim%2C+Hee+Yong&rft.aulast=Akbar&rft.aufirst=M&rft.date=2005-10-01&rft.volume=4&rft.issue=4&rft.spage=466&rft.isbn=&rft.btitle=&rft.title=Indian+Journal+of+Biotechnology&rft.issn=09725849&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Aequorea victoria; Protein kinase C; Green fluorescent protein; Phospholipase C; pleckstrin; Phorbol esters; AKT protein; Acetic acid; Insulin-like growth factors; Insulin; Neuroblastoma; Staurosporine; 1-Phosphatidylinositol 3-kinase ER - TY - JOUR T1 - Mutator Phenotype Resulting from DNA Polymerase IV Overproduction in Escherichia coli: Preferential Mutagenesis on the Lagging Strand AN - 17423722; 6527578 AB - We investigated the mutator effect resulting from overproduction of Escherichia coli DNA polymerase IV. Using lac mutational targets in the two possible orientations on the chromosome, we observed preferential mutagenesis during lagging strand synthesis. The mutator activity likely results from extension of mismatches produced by polymerase III holoenzyme. JF - Journal of Bacteriology AU - Kuban, Wojciech AU - Banach-Orlowska, Magdalena AU - Bialoskorska, Malgorzata AU - Lipowska, Aleksandra AU - Schaaper, Roel M AU - Jonczyk, Piotr AU - Fijalkowska, Iwona J AD - Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02 106 Warsaw, Poland. Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 Y1 - 2005/10/01/ PY - 2005 DA - 2005 Oct 01 SP - 6862 EP - 6866 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 187 IS - 19 SN - 0021-9193, 0021-9193 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Chromosomes KW - DNA-directed DNA polymerase KW - Escherichia coli KW - Mutagenesis KW - N 14835:Protein-Nucleic Acids Association KW - J 02740:Genetics and evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17423722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Mutator+Phenotype+Resulting+from+DNA+Polymerase+IV+Overproduction+in+Escherichia+coli%3A+Preferential+Mutagenesis+on+the+Lagging+Strand&rft.au=Kuban%2C+Wojciech%3BBanach-Orlowska%2C+Magdalena%3BBialoskorska%2C+Malgorzata%3BLipowska%2C+Aleksandra%3BSchaaper%2C+Roel+M%3BJonczyk%2C+Piotr%3BFijalkowska%2C+Iwona+J&rft.aulast=Kuban&rft.aufirst=Wojciech&rft.date=2005-10-01&rft.volume=187&rft.issue=19&rft.spage=6862&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-01-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Chromosomes; DNA-directed DNA polymerase; Mutagenesis; Escherichia coli ER - TY - JOUR T1 - Role of RcsF in Signaling to the Rcs Phosphorelay Pathway in Escherichia coli AN - 17419839; 6527566 AB - The rcs phosphorelay pathway components were originally identified as regulators of capsule synthesis. In addition to the transmembrane sensor kinase RcsC, the RcsA coregulator, and the response regulator RcsB, two new components have been characterized, RcsD and RcsF. RcsD, the product of the yojN gene, now renamed rcsD, acts as a phosphorelay between RcsC and RcsB. Transcription of genes for capsule synthesis (cps) requires both RcsA and RcsB; transcription of other promoters, including that for the small RNA RprA, requires only RcsB. RcsF was described as an alternative sensor kinase for RcsB. We have examined the role of RcsF in the activation of both the rprA and cps promoters. We find that a number of signals that lead to activation of the phosphorelay require both RcsF and RcsC; epistasis experiments place RcsF upstream of RcsC. The RcsF sequence is characteristic of lipoproteins, consistent with a role in sensing cell surface perturbation and transmitting this signal to RcsC. Activation of RcsF does not require increased transcription of the gene, suggesting that modification of the RcsF protein may act as an activating signal. Signals from RcsC require RcsD to activate RcsB. Sequencing of an rcsC allele, rcsC137, that leads to high-level constitutive expression of both cps and rprA suggests that the response regulator domain of RcsC plays a role in negatively regulating the kinase activity of RcsC. The phosphorelay and the variation in the activation mechanism (dependent upon or independent of RcsA) provide multiple steps for modulating the output from this system. JF - Journal of Bacteriology AU - Majdalani, Nadim AU - Heck, Michael AU - Stout, Valerie AU - Gottesman, Susan AD - Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892. School of Life Sciences, Arizona State University, Tempe, Arizona 85287-4501 Y1 - 2005/10/01/ PY - 2005 DA - 2005 Oct 01 SP - 6770 EP - 6778 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 187 IS - 19 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Promoters KW - Cell surface KW - RNA KW - Epistasis KW - Lipoproteins KW - Escherichia coli KW - Transcription KW - Signal transduction KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17419839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Role+of+RcsF+in+Signaling+to+the+Rcs+Phosphorelay+Pathway+in+Escherichia+coli&rft.au=Majdalani%2C+Nadim%3BHeck%2C+Michael%3BStout%2C+Valerie%3BGottesman%2C+Susan&rft.aulast=Majdalani&rft.aufirst=Nadim&rft.date=2005-10-01&rft.volume=187&rft.issue=19&rft.spage=6770&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-01-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cell surface; Promoters; RNA; Epistasis; Lipoproteins; Transcription; Signal transduction; Escherichia coli ER - TY - JOUR T1 - Modifying the NH sub(2) and COOH Termini of Aquaporin-5: Effects on Localization in Polarized Epithelial Cells AN - 17416101; 6537910 AB - To reengineer polarized epithelial cell functions directly in situ, or ex vivo in the fabrication of an artificial organ, it is necessary to understand mechanisms that account for polarized membrane sorting. We have used the aquaporins (AQPs), a family of homotetrameric water channel proteins, as model membrane proteins for this purpose. AQP monomers contain six transmembrane-spanning domains linked by five interconnecting loops, with the NH sub(2) and COOH termini residing in the cytosol. AQP5 is localized in the apical membranes of several different epithelia in vivo, and in stably transfected MDCK-II cells grown as a polarized monolayer. We wished to identify a structural region(s) within rat AQP5 (rAQP5) important for apical localization, and to study the MDCK-II cell localization of rAQP5s modified in either their NH sub(2) or COOH terminus. We show that the NH sub(2)- terminal region does not play a major role in apical localization as deletion of the NH sub(2) terminus produced a modified rAQP5 construct (AQP5- NT sub(del)) that was stably expressed and localized primarily to the apical membranes of MDCK-II cells. Attachment of a FLAG epitope to the NH sub(2) terminus of AQP5 (AQP5 sub(flag) construct) also did not perturb apical localization. In addition, we found that the exchange of NH sub(2)-terminal regions between rAQP5 and human AQP1 (hAQP1; a nonpolarized AQP isoform) produced a modified rAQP5 construct (AQP5-1NT) and a modified hAQP1 construct (AQP1-5NT), each of which localized as the parental AQP (apically, and to both apical and basolateral membranes, respectively). In contrast, we found that deletion of the COOH terminus resulted in a modified rAQP5 construct (AQP5-CT sub(del)) that was unstably expressed and localized to intracellular site(s) in MDCK-II cells. Substitution of the COOH terminus of AQP1 with the COOH terminus of AQP5 also produced a construct (AQP1-5CT) transiently expressed in intracellular compartment(s). However, substitution of the COOH terminus of rAQP5 with the COOH terminus of hAQP1 produced a modified rAQP5 construct (AQP5-1CT) that was stably expressed and localized to basolateral membranes, suggesting the loss of an apical targeting/retention signal from rAQP5, the gain of a basolateral targeting/retention signal from hAQP1, or a combination of these two possibilities. JF - Tissue Engineering AU - Wellner, R B AU - Hong, Sohee AU - Cotrim, A P AU - Swaim, W D AU - Baum, B J AD - Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 10, Room 1N113, 10 Center Drive, MSC 1190, Bethesda, MD 20892-1190, USA, bbaum@dir.nidcr.nih.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 1449 EP - 1458 VL - 11 IS - 9-10 SN - 1076-3279, 1076-3279 KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Epithelial cells KW - Clonal deletion KW - Aquaporin 1 KW - aquaporins KW - Membrane proteins KW - Polarization KW - Tissue engineering KW - Monomers KW - Cytosol KW - Epitopes KW - artificial organs KW - W 30965:Miscellaneous, Reviews KW - W3 33220:Cell culture KW - W4 110:Biomedical Materials & Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17416101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering&rft.atitle=Modifying+the+NH+sub%282%29+and+COOH+Termini+of+Aquaporin-5%3A+Effects+on+Localization+in+Polarized+Epithelial+Cells&rft.au=Wellner%2C+R+B%3BHong%2C+Sohee%3BCotrim%2C+A+P%3BSwaim%2C+W+D%3BBaum%2C+B+J&rft.aulast=Wellner&rft.aufirst=R&rft.date=2005-10-01&rft.volume=11&rft.issue=9-10&rft.spage=1449&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering&rft.issn=10763279&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Clonal deletion; Aquaporin 1; Epithelial cells; artificial organs; Cytosol; Monomers; Tissue engineering; Membrane proteins; Epitopes; aquaporins; Polarization ER - TY - JOUR T1 - Anti-IFN- gamma Autoantibodies in Disseminated Nontuberculous Mycobacterial Infections AN - 17410141; 6528263 AB - Although many patients with disseminated nontuberculous mycobacterial disease have molecular defects in the IFN- gamma /IL-12 axis, recent case reports have shown autoantibodies against IFN- gamma associated with severe nontuberculous mycobacterial infections. To check this finding in an independent population, we screened 35 patients with either disseminated or pulmonary nontuberculous mycobacterial infections for whom no molecular defect was known. We identified high-titer-neutralizing anti-IFN- gamma IgG in the plasma of six patients. All six patients were female, parous, of East Asian descent, and had disseminated infection, predominantly with rapidly growing mycobacteria. The anti-IFN- gamma IgG had in vitro biological activity on the IFN- gamma -dependent phosphorylation of STAT-1 as well as on the IFN- gamma -dependent up-regulation of TNF- alpha and IL-12. In contrast, this anti-IFN- gamma Ab had no effect on IFN- alpha -dependent STAT-1 phosphorylation. These patients confirm a novel syndrome linking autoimmunity and immunodeficiency. JF - Journal of Immunology AU - Patel, Smita Y AU - Ding, Li AU - Brown, Margaret R AU - Lantz, Larry AU - Gay, Ted AU - Cohen, Stuart AU - Martyak, Lenna A AU - Kubak, Bernard AU - Holland, Steven M AD - Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892. Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD 20892. Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892. Tri City Medical Center, Oceanside, CA 92056. University of California, Davis School of Medicine, Sacramento, CA 95817. University of California, Los Angeles School of Medicine, Los Angeles, CA 90095 Y1 - 2005/10/01/ PY - 2005 DA - 2005 Oct 01 SP - 4769 EP - 4776 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 175 IS - 7 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - gamma -Interferon KW - Disseminated infection KW - Immunodeficiency KW - Autoimmunity KW - Interleukin 12 KW - Phosphorylation KW - Autoantibodies KW - Case reports KW - Stat1 protein KW - Lung KW - Immunoglobulin G KW - Tumor necrosis factor- alpha KW - F 06366:Respiratory System: Clinical KW - J 02845:Ear, nose and respiratory tract UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17410141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Anti-IFN-+gamma+Autoantibodies+in+Disseminated+Nontuberculous+Mycobacterial+Infections&rft.au=Patel%2C+Smita+Y%3BDing%2C+Li%3BBrown%2C+Margaret+R%3BLantz%2C+Larry%3BGay%2C+Ted%3BCohen%2C+Stuart%3BMartyak%2C+Lenna+A%3BKubak%2C+Bernard%3BHolland%2C+Steven+M&rft.aulast=Patel&rft.aufirst=Smita&rft.date=2005-10-01&rft.volume=175&rft.issue=7&rft.spage=4769&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Interleukin 12; gamma -Interferon; Case reports; Autoantibodies; Phosphorylation; Lung; Stat1 protein; Disseminated infection; Immunodeficiency; Immunoglobulin G; Autoimmunity; Tumor necrosis factor- alpha ER - TY - JOUR T1 - Habitual physical activity in children: the role of genes and the environment AN - 17407114; 6511748 AB - Background: Understanding the factors that contribute to physical inactivity in children is important because sedentary behavior strongly relates to metabolic disorders such as obesity and diabetes. Objective: We aimed to quantify the genetic and environmental influences on physical activity energy expenditure (PAEE) in 100 sex-concordant dizygotic (n = 38) and monozygotic (n = 62) twin pairs aged 4-10 y. Design: Resting metabolic rate (RMR) was assessed by using respiratory gas exchange, total energy expenditure (TEE) by using doubly labeled water, and body composition by using dual-energy X-ray absorptiometry. Structural equation modeling was used to partition the phenotypic variance into additive genetic (a super(2)) and common (c super(2)) and unshared (e super(2)) environmental components. Results: Because PAEE [TEE - (RMR + 0.1 x TEE)] depends on body weight, which is highly heritable, we tested several models: 1) after adjustment for age, sex, ethnicity, study date, season, and weight, a super(2) explained none of the phenotypic variance in PAEE (95% CI: 0%, 38%), whereas c super(2) and e super(2) accounted for 69% (33%, 77%; P = 0.001) and 31% (23%, 39%; P < 0.001) of the variance, respectively; 2) after adjustment for the cofactors in model 1, a super(2) explained 19% of the phenotypic variance in TEE (0%, 60%; P = 0.13), whereas c super(2) and e super(2) accounted for 59% (16%, 79%; P = 0.007) and 23% (17%, 31%; P < 0.0001) of the variance, respectively; 3) in models adjusted as above (excluding weight), a super(2) explained no variance in physical activity level (TEE/RMR) (0%, 32%; P = 0.50), whereas c super(2) and e super(2) explained 65% (34%, 60%; P = 0.001) and 35% (28%, 45%; P < 0.0001) of the variance, respectively. Conclusions: Our data suggest that the familial resemblance in physical activity in these children is explained. JF - American Journal of Clinical Nutrition AU - Franks, P W AU - Ravussin, E AU - Hanson, R L AU - Harper, I T AU - Allison, D B AU - Knowler, W C AU - Tataranni, P A AU - Salbe, AD AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA Y1 - 2005/10/01/ PY - 2005 DA - 2005 Oct 01 SP - 901 EP - 908 VL - 82 IS - 4 SN - 0002-9165, 0002-9165 KW - Genetics Abstracts; Physical Education Index KW - Gas exchange KW - Age KW - Physical activity KW - Metabolic rate KW - Dual energy X-ray absorptiometry KW - Nutrition KW - Water KW - Models KW - Genetics KW - Body weight KW - Weight KW - Body composition KW - Ethnic groups KW - Sex KW - Obesity KW - Mathematical models KW - Data processing KW - Metabolic disorders KW - Basal metabolic rate KW - Exercise KW - Children KW - Diabetes KW - Diabetes mellitus KW - Energy cost KW - X-Ray KW - Twins KW - Energy expenditure KW - Cofactors KW - Behavior KW - Modeling KW - G 07880:Human Genetics KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17407114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Clinical+Nutrition&rft.atitle=Habitual+physical+activity+in+children%3A+the+role+of+genes+and+the+environment&rft.au=Franks%2C+P+W%3BRavussin%2C+E%3BHanson%2C+R+L%3BHarper%2C+I+T%3BAllison%2C+D+B%3BKnowler%2C+W+C%3BTataranni%2C+P+A%3BSalbe%2C+AD&rft.aulast=Franks&rft.aufirst=P&rft.date=2005-10-01&rft.volume=82&rft.issue=4&rft.spage=901&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Clinical+Nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Gas exchange; Obesity; Age; Basal metabolic rate; Exercise; Children; Nutrition; Water; Diabetes; X-Ray; Energy cost; Genetics; Weight; Behavior; Body composition; Modeling; Sex; Data processing; Mathematical models; Metabolic disorders; Physical activity; Dual energy X-ray absorptiometry; Metabolic rate; Models; Diabetes mellitus; Cofactors; Energy expenditure; Twins; Body weight; Ethnic groups ER - TY - JOUR T1 - Inactivation of Retroviruses with Preservation of Structural Integrity by Targeting the Hydrophobic Domain of the Viral Envelope AN - 17405288; 6528592 AB - We describe a new approach for the preparation of inactivated retroviruses for vaccine application. The lipid domain of the viral envelope was selectively targeted to inactivate proteins and lipids therein and block fusion of the virus with the target cell membrane. In this way, complete elimination of the infectivity of human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) could be achieved with preservation of antigenic determinants on the surface of the viral envelope. Inactivation was accomplished by modification of proteins and lipids in the viral envelope using the hydrophobic photoinduced alkylating probe 1,5 iodonaphthylazide (INA). Treatment of HIV and SIV isolates with INA plus light completely blocked fusion of the viral envelope and abolished infectivity. The inactivated virus remained structurally unchanged, with no detectable loss of viral proteins. Modifications to envelope and nucleocapsid proteins were detected by changes in their elution pattern on reverse-phase high-performance liquid chromatography. These modifications had no effect on primary and secondary structure epitopes as determined by monoclonal antibodies. Likewise, the inactivated HIV reacted as well as the live virus with the conformation-sensitive and broadly neutralizing anti-HIV type 1 monoclonal antibodies 2G12, b12, and 4E10. Targeting the lipid domain of biological membranes with hydrophobic alkylating compounds could be used as a general approach for inactivation of enveloped viruses and other pathogenic microorganisms for vaccine application. JF - Journal of Virology AU - Raviv, Yossef AU - Viard, Mathias AU - Bess, Julian W, Jr AU - Chertova, Elena AU - Blumenthal, Robert AD - Center for Cancer Research Nanobiology Program. Basic Research Program, SAIC. AIDS Vaccine Program, SAIC, National Cancer Institute, Frederick, Maryland Y1 - 2005/10/01/ PY - 2005 DA - 2005 Oct 01 SP - 12394 EP - 12400 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 79 IS - 19 SN - 0022-538X, 0022-538X KW - HIV KW - SIV KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - High-performance liquid chromatography KW - Monoclonal antibodies KW - Lipids KW - Secondary structure KW - Probes KW - Hydrophobicity KW - Light effects KW - Protein structure KW - Infectivity KW - Retrovirus KW - Envelopes KW - Human immunodeficiency virus KW - Antigenic determinants KW - Nucleocapsids KW - Microorganisms KW - Vaccines KW - Preservation KW - Simian immunodeficiency virus KW - Epitopes KW - A 01340:Antibiotics & Antimicrobials KW - V 22002:AIDS: Molecular and in vitro aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17405288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Inactivation+of+Retroviruses+with+Preservation+of+Structural+Integrity+by+Targeting+the+Hydrophobic+Domain+of+the+Viral+Envelope&rft.au=Raviv%2C+Yossef%3BViard%2C+Mathias%3BBess%2C+Julian+W%2C+Jr%3BChertova%2C+Elena%3BBlumenthal%2C+Robert&rft.aulast=Raviv&rft.aufirst=Yossef&rft.date=2005-10-01&rft.volume=79&rft.issue=19&rft.spage=12394&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-01-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Monoclonal antibodies; Lipids; Secondary structure; Probes; Hydrophobicity; Light effects; Protein structure; Infectivity; Envelopes; Antigenic determinants; Microorganisms; Nucleocapsids; Preservation; Vaccines; Epitopes; Retrovirus; Human immunodeficiency virus; Simian immunodeficiency virus ER - TY - JOUR T1 - EVOPRINTER, a multigenomic comparative tool for rapid identification of functionally important DNA AN - 17400084; 6505009 AB - Here, we describe a multigenomic DNA sequence-analysis tool, EVOPRINTER, that facilitates the rapid identification of evolutionary conserved sequences within the context of a single species. The EVOPRINTER output identifies multispecies-conserved DNA sequences as they exist in a reference DNA. This identification is accomplished by superimposing multiple reference DNA vs. test-genome pairwise BLAT (BLAST-like alignment tool) readouts of the reference DNA to identify conserved nucleotides that are shared by all orthologous DNAs. EVOPRINTER analysis of well characterized genes reveals that most, if not all, of the conserved sequences are essential for gene function. For example, analysis of orthologous genes that are shared by many vertebrates identifies conserved DNA in both protein-encoding sequences and noncoding cis-regulatory regions, including enhancers and mRNA microRNA binding sites. In Drosophila, the combined mutational histories of five or more species affords near-base pair resolution of conserved transcription factor DNA-binding sites, and essential amino acids are revealed by the nucleotide flexibility of their codon-wobble position(s). Conserved small peptide-encoding genes, which had been undetected by conventional gene-prediction algorithms, are identified by the codon-wobble signatures of invariant amino acids. Also, EVOPRINTER allows one to assess the degree of evolutionary divergence between orthologous DNAs by highlighting differences between a selected species and the other test species. JF - Proceedings of the National Academy of Sciences, USA AU - Odenwald, Ward F AU - Rasband, Wayne AU - Kuzin, Alexander AU - Brody, Thomas AD - Neural Cell-Fate Determinants Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 14700 EP - 14705 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 102 IS - 41 SN - 0027-8424, 0027-8424 KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Entomology Abstracts KW - Algorithms KW - DNA sequencing KW - Amino acids KW - miRNA KW - Assays KW - Enhancers KW - Transcription factors KW - Bioinformatics KW - Drosophila KW - Evolution KW - N 14010:Physical & Computer Methods & Assays KW - Z 05216:Biochemical genetics KW - W 30965:Miscellaneous, Reviews KW - W4 350:Bioinformatics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17400084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=EVOPRINTER%2C+a+multigenomic+comparative+tool+for+rapid+identification+of+functionally+important+DNA&rft.au=Odenwald%2C+Ward+F%3BRasband%2C+Wayne%3BKuzin%2C+Alexander%3BBrody%2C+Thomas&rft.aulast=Odenwald&rft.aufirst=Ward&rft.date=2005-10-01&rft.volume=102&rft.issue=41&rft.spage=14700&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Drosophila; DNA sequencing; Amino acids; Bioinformatics; Assays; Evolution; Algorithms; miRNA; Enhancers; Transcription factors ER - TY - JOUR T1 - Induction of Invasive Mouse Skin Carcinomas in Transgenic Mice with Mutations in Both H-ras and p53 AN - 17400064; 6509469 AB - Synergistic interaction between H-ras and p53 were systematically examined during skin tumorigenesis. Concurrent expression of an activated H-ras gene and a mutant p53 gene was accomplished by crossing p53 super(Val135/wt) mice with TG.AC mice. Topical application to wild-type mice with benzo(a)pyrene (BaP) alone produced similar to 26% skin tumor incidence, whereas BaP treatment of p53 super(wt/wt)Hras super(TG.AC/wt), p53 super(Val135/wt)Hras super(wt/wt), and p53 super(Val135/wt)Hras super(TG.AC/wt) mice produced a 75%, 77%, and 100% incidence of skin tumors, respectively. An average of 0.33 tumor per mouse was observed in wild-type (p53 super(wt/wt)Hras super(wt/wt)) mice, whereas similar to 1.54, 1.96, and 3.08 tumors per mouse were seen in BaP-treated p53 super(wt/wt)Hras super(TG.AC/wt), p53 super(Val135/wt)Hras super(wt/wt), and p53 super(Val135/wt)Hras super(TG.AC/wt) mice, respectively. The effects on total tumor volume were even more striking with 7-, 48-, and 588-fold increases in tumor volume compared with wild-type (p53 super(wt/wt)Hras super(wt/wt)) in p53 super(wt/wt)Hras super(TG.AC/wt), p53 super(Val135/wt)Hras super(wt/wt), and p53 super(Val135/wt)Hras super(TG.AC/wt) mice, respectively. Histopathologically, all tumors from p53 super(wt/wt)Hras super(wt/wt) mice were either papillomas or well-differentiated squamous cell carcinomas, whereas the tumors in p53 super(wt/wt)Hras super(TG.AC/wt), p53 super(Val135/wt)Hras super(wt/wt), and p53 super(Val135/wt)Hras super(TG.AC/wt) mice were principally squamous cell carcinomas with varying degree of invasiveness. Particularly, tumors in p53 super(Val135/wt)Hras super(TG.AC/wt) mice exhibited the most rapid growth and the extreme form of tumor invasion. Microarray analysis revealed that dominant-negative p53 (Val super(135)) and activated H-ras affected several cellular processes involved in tumorigenesis possibly through its effects on apoptosis, cell cycle arrest, and Ras-mitogen-activated protein kinase pathways. The present study provides the first in vivo evidence that a germ line p53 mutation and activated H-ras act synergistically to profoundly enhance tumor progression. JF - Molecular Cancer Research AU - Zhang, Zhongqiu AU - Yao, Ruisheng AU - Li, Jie AU - Wang, Yian AU - Boone, Charles W AU - Lubet, Ronald A AU - You, Ming AD - Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri and Chemoprevention Branch, National Cancer Institute, Bethesda, Maryland Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 563 EP - 574 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 3 IS - 10 SN - 1541-7786, 1541-7786 KW - Genetics Abstracts; Oncogenes & Growth Factors Abstracts; Biotechnology and Bioengineering Abstracts KW - Invasiveness KW - Skin KW - Apoptosis KW - H-Ras protein KW - Cell cycle KW - Tumorigenesis KW - squamous cell carcinoma KW - Transgenic mice KW - skin carcinoma KW - p53 protein KW - Topical application KW - Protein kinase KW - Benzo(a)pyrene KW - Papilloma KW - Mutation KW - Hras gene KW - W 30925:Genetic Engineering KW - B 26670:Tumor Suppressors KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17400064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cancer+Research&rft.atitle=Induction+of+Invasive+Mouse+Skin+Carcinomas+in+Transgenic+Mice+with+Mutations+in+Both+H-ras+and+p53&rft.au=Zhang%2C+Zhongqiu%3BYao%2C+Ruisheng%3BLi%2C+Jie%3BWang%2C+Yian%3BBoone%2C+Charles+W%3BLubet%2C+Ronald+A%3BYou%2C+Ming&rft.aulast=Zhang&rft.aufirst=Zhongqiu&rft.date=2005-10-01&rft.volume=3&rft.issue=10&rft.spage=563&rft.isbn=&rft.btitle=&rft.title=Molecular+Cancer+Research&rft.issn=15417786&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Invasiveness; Apoptosis; Skin; H-Ras protein; Tumorigenesis; Cell cycle; squamous cell carcinoma; Transgenic mice; Topical application; p53 protein; skin carcinoma; Protein kinase; Benzo(a)pyrene; Papilloma; Mutation; Hras gene ER - TY - JOUR T1 - Recombination Hotspots and Population Structure in Plasmodium falciparum AN - 17398750; 6514407 AB - Understanding the influences of population structure, selection, and recombination on polymorphism and linkage disequilibrium (LD) is integral to mapping genes contributing to drug resistance or virulence in Plasmodium falciparum. The parasites short generation time, coupled with a high cross-over rate, can cause rapid LD break-down. However, observations of low genetic variation have led to suggestions of effective clonality: selfing, population admixture, and selection may preserve LD in populations. Indeed, extensive LD surrounding drug-resistant genes has been observed, indicating that recombination and selection play important roles in shaping recent parasite genome evolution. These studies, however, provide only limited information about haplotype variation at local scales. Here we describe the first (to our knowledge) chromosome-wide SNP haplotype and population recombination maps for a global collection of malaria parasites, including the 3D7 isolate, whose genome has been sequenced previously. The parasites are clustered according to continental origin, but alternative groupings were obtained using SNPs at 37 putative transporter genes that are potentially under selection. Geographic isolation and highly variable multiple infection rates are the major factors affecting haplotype structure. Variation in effective recombination rates is high, both among populations and along the chromosome, with recombination hotspots conserved among populations at chromosome ends. This study supports the feasibility of genome-wide association studies in some parasite populations. JF - PLoS Biology AU - Mu, Jianbing AU - Awadalla, Philip AU - Duan, Junhui AU - McGee, Kate M AU - Joy, Deirdre A AU - McVean, Gilean AT AU - Su, Xin-Zhuan AD - Laboratory of Malaria and Vector Research, National Institutes of Health, Rockville, Maryland, United States of America, xsu@niaid.nih.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 PB - Public Library of Science, 185 Berry Street Suite 1300 San Francisco CA 94107 USA, [mailto:plos@plos.org], [URL:http://www.plos.org] VL - 3 IS - 10 SN - 1544-9173, 1544-9173 KW - Ecology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Genetics Abstracts KW - Hot spots KW - Gene polymorphism KW - Drug resistance KW - Genetic diversity KW - Malaria KW - Plasmodium falciparum KW - Virulence KW - Linkage disequilibrium KW - Recombination KW - Chromosomes KW - Haplotypes KW - Single-nucleotide polymorphism KW - Population structure KW - Evolutionary genetics KW - Gene mapping KW - G 07361:Protozoans/slime molds KW - D 04655:Invertebrates - general KW - K 03081:Protozoa UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17398750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Biology&rft.atitle=Recombination+Hotspots+and+Population+Structure+in+Plasmodium+falciparum&rft.au=Mu%2C+Jianbing%3BAwadalla%2C+Philip%3BDuan%2C+Junhui%3BMcGee%2C+Kate+M%3BJoy%2C+Deirdre+A%3BMcVean%2C+Gilean+AT%3BSu%2C+Xin-Zhuan&rft.aulast=Mu&rft.aufirst=Jianbing&rft.date=2005-10-01&rft.volume=3&rft.issue=10&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Biology&rft.issn=15449173&rft_id=info:doi/10.1371%2Fjournal.pbio.0030335 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Hot spots; Drug resistance; Gene polymorphism; Genetic diversity; Malaria; Virulence; Recombination; Linkage disequilibrium; Chromosomes; Haplotypes; Single-nucleotide polymorphism; Population structure; Evolutionary genetics; Gene mapping; Plasmodium falciparum DO - http://dx.doi.org/10.1371/journal.pbio.0030335 ER - TY - JOUR T1 - Crystal structure of the Yersinia type III secretion protein YscE AN - 17392323; 6508274 AB - The plague-causing bacterium Yersinia pestis utilizes a contact-dependent (type III) secretion system (T3SS) to transport virulence factors from the bacterial cytosol directly into the interior of mammalian cells where they interfere with signal transduction pathways that mediate phagocytosis and the inflammatory response. The type III secretion apparatus is composed of 20-25 different Yersinia secretion (Ysc) proteins. We report here the structure of YscE, the smallest Ysc protein, which is a dimer in solution. The probable mode of oligomerization is discussed. JF - Protein Science AU - Phan, Jason AU - Austin, Brian P AU - Waugh, David S AD - Macromolecular Crystallography Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702-1201, USA Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 2759 EP - 2763 PB - Cold Spring Harbor Laboratory Press, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 14 IS - 10 SN - 0961-8368, 0961-8368 KW - YscE protein KW - Microbiology Abstracts B: Bacteriology KW - virulence factors KW - Mammalian cells KW - Secretion KW - Oligomerization KW - Cytosol KW - Crystal structure KW - Yersinia pestis KW - Plague KW - Phagocytosis KW - Inflammation KW - Signal transduction KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17392323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Science&rft.atitle=Crystal+structure+of+the+Yersinia+type+III+secretion+protein+YscE&rft.au=Phan%2C+Jason%3BAustin%2C+Brian+P%3BWaugh%2C+David+S&rft.aulast=Phan&rft.aufirst=Jason&rft.date=2005-10-01&rft.volume=14&rft.issue=10&rft.spage=2759&rft.isbn=&rft.btitle=&rft.title=Protein+Science&rft.issn=09618368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Mammalian cells; virulence factors; Secretion; Oligomerization; Crystal structure; Cytosol; Plague; Phagocytosis; Signal transduction; Inflammation; Yersinia pestis ER - TY - JOUR T1 - High-Resolution Serum Proteomic Profiling of Alzheimer Disease Samples Reveals Disease-Specific, Carrier-Protein-Bound Mass Signatures AN - 17385924; 6502847 AB - BACKGROUND: Researchers typically search for disease markers using a "targeted" approach in which a hypothesis about the disease mechanism is tested and experimental results either confirm or disprove the involvement of a particular gene or protein in the disease. Recently, there has been interest in developing disease diagnostics based on unbiased quantification of differences in global patterns of protein and peptide masses, typically in blood from individuals with and without disease. We combined a suite of methods and technologies, including novel sample preparation based on carrier-protein capture and biomarker enrichment, high-resolution mass spectrometry, a unique cohort of well-characterized persons with and without Alzheimer disease (AD), and powerful bioinformatic analysis, that add statistical and procedural robustness to biomarker discovery from blood. METHODS: Carrier-protein-bound peptides were isolated from serum samples by affinity chromatography, and peptide mass spectra were acquired by a matrix-assisted laser desorption/ionization (MALDI) orthogonal time-of-flight (O-TOF) mass spectrometer capable of collecting data over a broad mass range (100 to >300 000 Da) in a single acquisition. Discriminatory analysis of mass spectra was used to process and analyze the raw mass spectral data. RESULTS: Coupled with the biomarker enrichment protocol, the high-resolution MALDI O-TOF mass spectra provided informative, reproducible peptide signatures. The raw mass spectra were analyzed and used to build discriminant disease models that were challenged with blinded samples for classification. CONCLUSIONS: Carrier-protein enrichment of disease biomarkers coupled with high-resolution mass spectrometry and discriminant pattern analysis is a powerful technology for diagnostics and population screening. The mass fingerprint model successfully classified blinded AD patient and control samples with high sensitivity and specificity. JF - Clinical Chemistry AU - Lopez, Mary F AU - Mikulskis, Alvydas AU - Kuzdzal, Scott AU - Bennett, David A AU - Kelly, Jeremiah AU - Golenko, Eva AU - DiCesare, Joseph AU - Denoyer, Eric AU - Patton, Wayne F AU - Ediger, Richard AU - Sapp, Lisa AU - Ziegert, Tillmann AU - Lynch, Christopher AU - Kramer, Susan AU - Whiteley, Gordon R AU - Wall, Michael R AU - Mannion, David P AU - della Cioppa, Guy AU - Rakitan, John S AU - Wolfe, Gershon M AD - PerkinElmer Life and Analytical Sciences, Boston, MA. PerkinElmer Life and Analytical Sciences, Shelton, CT. Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL. PerkinElmer Life and Analytical Sciences, Beaconsfield, Bucks, United Kingdom. Clinical Proteomics Reference Laboratory, SAIC-Frederick, Inc., NCI Frederick, Gaithersburg, MD. Predictive Diagnostics, Inc., Vacaville, CA Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 1946 EP - 1954 PB - American Association for Clinical Chemistry, Inc. VL - 51 IS - 10 SN - 0009-9147, 0009-9147 KW - man KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Bioengineering Abstracts KW - Alzheimer's disease KW - Statistical analysis KW - biomarkers KW - Blood KW - proteomics KW - Bioinformatics KW - W4 130:General Biomedical Engineering: Tools & Techniques KW - G 07433:Miscellaneous KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17385924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Chemistry&rft.atitle=High-Resolution+Serum+Proteomic+Profiling+of+Alzheimer+Disease+Samples+Reveals+Disease-Specific%2C+Carrier-Protein-Bound+Mass+Signatures&rft.au=Lopez%2C+Mary+F%3BMikulskis%2C+Alvydas%3BKuzdzal%2C+Scott%3BBennett%2C+David+A%3BKelly%2C+Jeremiah%3BGolenko%2C+Eva%3BDiCesare%2C+Joseph%3BDenoyer%2C+Eric%3BPatton%2C+Wayne+F%3BEdiger%2C+Richard%3BSapp%2C+Lisa%3BZiegert%2C+Tillmann%3BLynch%2C+Christopher%3BKramer%2C+Susan%3BWhiteley%2C+Gordon+R%3BWall%2C+Michael+R%3BMannion%2C+David+P%3Bdella+Cioppa%2C+Guy%3BRakitan%2C+John+S%3BWolfe%2C+Gershon+M&rft.aulast=Lopez&rft.aufirst=Mary&rft.date=2005-10-01&rft.volume=51&rft.issue=10&rft.spage=1946&rft.isbn=&rft.btitle=&rft.title=Clinical+Chemistry&rft.issn=00099147&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Alzheimer's disease; biomarkers; Blood; Statistical analysis; Bioinformatics; proteomics ER - TY - JOUR T1 - A live-cell assay to detect antigen-specific CD4 super(+) T cells with diverse cytokine profiles AN - 17238807; 6986618 AB - Recently activated, but not resting, CD4 super(+) T cells express CD154, providing costimulatory signals to B cells and antigen-presenting cells (APCs). Therefore, de novo CD154 expression after stimulation identifies antigen- specific CD4 super(+) T cells. Previous assays were limited by the transient nature of surface CD154 expression; we overcame this by including fluorescently conjugated CD154-specific antibody during stimulation. Our assay is fully compatible with intracellular cytokine staining, and can be used for stimulations as long as 24 h. Notably, it is nonlethal, providing a means to purify viable antigen-specific CD4 super(+) T cells for further analysis. Using this assay, we found that stimulated cells expressing tumor necrosis factor (TNF)- [alpha], interleukin (IL)-2 or interferon (IFN)-[gamma] were predominantly CD154 super(+). Furthermore, some cells expressing none of these cytokines also expressed CD154, suggesting that CD154 marks cells with other effector functions. For vaccine- or pathogen-specific responses, we found substantial heterogeneity in expression of CD154 and cytokines, suggesting previously unrecognized diversity in abilities of responding cells to stimulate APCs through CD40. JF - Nature Medicine AU - Chattopadhyay, Pratip K AU - Yu, Joanne AU - Roederer, Mario AD - ImmunoTechnology Section, Vaccine Research Center, National Institute of Allergy and Infectious Disease, National Institutes of Health, 40 Convent Drive, Room 5509, Bethesda, Maryland 20892, USA., roederer@nih.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 1113 EP - 1117 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 11 IS - 10 SN - 1078-8956, 1078-8956 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Interleukins KW - CD4 antigen KW - adenomatous polyposis coli KW - Lymphocytes T KW - Cytokines KW - Antigen-presenting cells KW - CD40 antigen KW - CD154 antigen KW - g-Interferon KW - Lymphocytes B KW - Tumor necrosis factor-a KW - Effector cells KW - Antibodies KW - ^g-Interferon KW - Tumor necrosis factor-^a KW - W3 33240:Immunology KW - F 06704:Immunoassays KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17238807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Medicine&rft.atitle=A+live-cell+assay+to+detect+antigen-specific+CD4+super%28%2B%29+T+cells+with+diverse+cytokine+profiles&rft.au=Chattopadhyay%2C+Pratip+K%3BYu%2C+Joanne%3BRoederer%2C+Mario&rft.aulast=Chattopadhyay&rft.aufirst=Pratip&rft.date=2005-10-01&rft.volume=11&rft.issue=10&rft.spage=1113&rft.isbn=&rft.btitle=&rft.title=Nature+Medicine&rft.issn=10788956&rft_id=info:doi/10.1038%2Fnm1293 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - CD154 antigen; CD40 antigen; CD4 antigen; Lymphocytes T; adenomatous polyposis coli; Effector cells; Antigen-presenting cells; Cytokines; Antibodies; Lymphocytes B; g-Interferon; Interleukins; Tumor necrosis factor-a; ^g-Interferon; Tumor necrosis factor-^a DO - http://dx.doi.org/10.1038/nm1293 ER - TY - JOUR T1 - Carbohydrate-binding molecules inhibit viral fusion and entry by crosslinking membrane glycoproteins AN - 17082812; 6709216 AB - Defensins are peptides that protect the host against microorganisms. Here we show that the theta-defensin retrocyclin 2 (RC2) inhibited influenza virus infection by blocking membrane fusion mediated by the viral hemagglutinin. RC2 was effective even after hemagglutinin attained a fusogenic conformation or had induced membrane hemifusion. RC2, a multivalent lectin, prevented hemagglutinin- mediated fusion by erecting a network of crosslinked and immobilized surface glycoproteins. RC2 also inhibited fusion mediated by Sindbis virus and baculovirus. Human beta-defensin 3 and mannan-binding lectin also blocked viral fusion by creating a protective barricade of immobilized surface proteins. This general mechanism might explain the broad-spectrum antiviral activity of many multivalent lectins of the innate immune system. JF - Nature Immunology AU - Leikina, Eugenia AU - Delanoe-Ayari, Helene AU - Melikov, Kamran AU - Cho, Myoung-Soon AU - Chen, Andrew AU - Waring, Alan J AU - Wang, Wei AU - Xie, Yongming AU - Loo, Joseph A AU - Lehrer, Robert I AU - Chernomordik, Leonid V AD - Section on Membrane Biology, Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, Bethesda, Maryland 20892-1855, USA., chernoml@mail.nih.gov Y1 - 2005/10// PY - 2005 DA - Oct 2005 SP - 995 EP - 1001 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 6 IS - 10 SN - 1529-2908, 1529-2908 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts KW - Membrane fusion KW - Immune system KW - Hemagglutinins KW - Antiviral activity KW - Infection KW - Influenza KW - Mannose-binding lectin KW - Defensins KW - Influenza virus KW - Sindbis virus KW - Microorganisms KW - mannose-binding lectin KW - Glycoproteins KW - Baculovirus KW - Membrane glycoproteins KW - Conformation KW - A 01340:Antibiotics & Antimicrobials KW - V 22094:Hemagglutinin & neuraminidase KW - V 22042:Adsorption, penetration & uncoating KW - F 06104:Virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17082812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Immunology&rft.atitle=Carbohydrate-binding+molecules+inhibit+viral+fusion+and+entry+by+crosslinking+membrane+glycoproteins&rft.au=Leikina%2C+Eugenia%3BDelanoe-Ayari%2C+Helene%3BMelikov%2C+Kamran%3BCho%2C+Myoung-Soon%3BChen%2C+Andrew%3BWaring%2C+Alan+J%3BWang%2C+Wei%3BXie%2C+Yongming%3BLoo%2C+Joseph+A%3BLehrer%2C+Robert+I%3BChernomordik%2C+Leonid+V&rft.aulast=Leikina&rft.aufirst=Eugenia&rft.date=2005-10-01&rft.volume=6&rft.issue=10&rft.spage=995&rft.isbn=&rft.btitle=&rft.title=Nature+Immunology&rft.issn=15292908&rft_id=info:doi/10.1038%2Fni1248 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Membrane fusion; Hemagglutinins; Immune system; Infection; Antiviral activity; Influenza; Mannose-binding lectin; Defensins; Microorganisms; mannose-binding lectin; Glycoproteins; Membrane glycoproteins; Conformation; Influenza virus; Sindbis virus; Baculovirus DO - http://dx.doi.org/10.1038/ni1248 ER - TY - JOUR T1 - Induction of transplantation tolerance in non-human primate preclinical models. AN - 68565719; 16147537 AB - Short-term outcomes following organ transplantation have improved considerably since the availability of cyclosporine ushered in the modern era of immunosuppression. In spite of this, many of the current limitations to progress in the field are directly related to the existing practice of relatively non-specific immunosuppression. These include increased risks of opportunistic infection and cancer, and toxicity associated with long-term immunosuppressive drug exposure. In addition, long-term graft loss continues to result in part from a failure to adequately control the anti-donor immune response. The development of a safe and reliable means of inducing tolerance would ameliorate these issues and improve the lives of transplant recipients, yet given the improving clinical standard of care, the translation of new therapies has become appropriately more cautious and dependent on increasingly predictive preclinical models. While convenient and easy to use, rodent tolerance models have not to date been reliably capable of predicting a therapy's potential efficacy in humans. Non-human primates possess an immune system that more closely approximates that found in humans, and have served as a more rigorous preclinical testing ground for novel therapies. Prior to clinical adaptation therefore, tolerance regimens should be vetted in non-human primates to ensure that there is sufficient potential for efficacy to justify the risk of its application. JF - Philosophical transactions of the Royal Society of London. Series B, Biological sciences AU - Hale, Douglas A AU - Dhanireddy, Kiran AU - Bruno, David AU - Kirk, Allan D AD - Digestive and Kidney Diseases, National Institute of Diabetes, NIH, Transplantation Branch, Bethesda, MD 20892, USA. douglash@intra.niddk.nih.gov Y1 - 2005/09/29/ PY - 2005 DA - 2005 Sep 29 SP - 1723 EP - 1737 VL - 360 IS - 1461 SN - 0962-8436, 0962-8436 KW - Antibodies, Monoclonal KW - 0 KW - Antilymphocyte Serum KW - Index Medicus KW - Animals KW - Transplantation Chimera -- immunology KW - Primates KW - Antilymphocyte Serum -- therapeutic use KW - Antibodies, Monoclonal -- therapeutic use KW - Transplantation Tolerance -- immunology KW - Models, Animal KW - Models, Immunological KW - Signal Transduction -- immunology KW - Immunosuppression -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68565719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Philosophical+transactions+of+the+Royal+Society+of+London.+Series+B%2C+Biological+sciences&rft.atitle=Induction+of+transplantation+tolerance+in+non-human+primate+preclinical+models.&rft.au=Hale%2C+Douglas+A%3BDhanireddy%2C+Kiran%3BBruno%2C+David%3BKirk%2C+Allan+D&rft.aulast=Hale&rft.aufirst=Douglas&rft.date=2005-09-29&rft.volume=360&rft.issue=1461&rft.spage=1723&rft.isbn=&rft.btitle=&rft.title=Philosophical+transactions+of+the+Royal+Society+of+London.+Series+B%2C+Biological+sciences&rft.issn=09628436&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-06 N1 - Date created - 2005-09-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Transplant. 2004 Sep;4(9):1391-8 [15307826] Acta Derm Venereol. 1968;48(5):429-34 [4177566] Acta Derm Venereol. 1968;48(5):435-52 [4177567] Fed Proc. 1970 Jan-Feb;29(1):151-2 [4391648] Transplantation. 1971 Sep;12(3):202-10 [4105459] Transplant Proc. 1971 Mar;3(1):676-9 [4398508] Transplantation. 1972 Aug;14(2):227-35 [4626074] Transplant Proc. 1973 Mar;5(1):597-600 [4633092] Eur Surg Res. 1970;2(6):408-14 [4950503] Transplantation. 1974 Aug;18(2):155-62 [4152539] Cell Transplant. 1996 Jan-Feb;5(1):49-52 [8665076] J Cell Biochem. 2003 Feb 1;88(2):227-33 [12520519] Transplantation. 1998 Mar 15;65(5):632-41 [9521196] J Immunol. 1997 Dec 1;159(11):5187-91 [9548454] JPEN J Parenter Enteral Nutr. 1998 May-Jun;22(3):152-5 [9586793] Transplantation. 1998 May 15;65(9):1159-69 [9603161] J Clin Invest. 1998 Jun 1;101(11):2446-55 [9616216] J Exp Med. 1998 Jun 15;187(12):2037-44 [9625763] Transplant Proc. 1998 Jun;30(4):1163 [9636469] Transpl Int. 1998;11 Suppl 1:S303-9 [9665002] Transplantation. 1998 Jul 15;66(1):5-13 [9679815] Lancet. 1998 Jun 6;351(9117):1701-2 [9734890] Transplantation. 1998 Nov 27;66(10):1285-91 [9846510] Acta Derm Venereol. 1968;48(5):453-64 [4177568] Lancet. 1970 Jan 24;1(7639):167-70 [4189240] Nat Med. 1999 Nov;5(11):1303-7 [10545998] Transplantation. 1999 Nov 15;68(9):1348-55 [10573075] J Immunol. 2000 Jan 1;164(1):512-21 [10605049] Transplantation. 1999 Dec 15;68(11):1660-73 [10609942] Transplantation. 1999 Dec 15;68(11):1767-75 [10609955] Transplantation. 1999 Dec 15;68(11):1800-5 [10609959] N Engl J Med. 2000 Mar 2;342(9):605-12 [10699159] J Exp Med. 2000 Feb 21;191(4):651-60 [10684857] Transplantation. 2000 Mar 27;69(6):1137-46 [10762219] Transplantation. 2000 Jun 15;69(11):2304-14 [10868630] Transplantation. 2000 Jun 27;69(12):2497-503 [10910269] Transplantation. 2000 Jul 27;70(2):368-74 [10933165] J Rheumatol. 2001 Jan;28(1):95-101 [11196549] Transplant Proc. 2001 Feb-Mar;33(1-2):116-7 [11266735] Transplant Proc. 2001 Feb-Mar;33(1-2):223-4 [11266788] Transplant Proc. 2001 Feb-Mar;33(1-2):675-6 [11267012] Philos Trans R Soc Lond B Biol Sci. 2001 May 29;356(1409):681-9 [11375071] Immunol Res. 2001;23(2-3):253-62 [11444390] Transplantation. 2001 Jul 27;72(2):351-4 [11477369] J Immunol. 2001 Aug 15;167(4):1945-53 [11489974] Transplantation. 2001 Aug 15;72(3):377-84 [11502964] Transplantation. 2001 Aug 27;72(4):581-7 [11544415] Transplantation. 2001 Aug 27;72(4):587-97 [11544416] Transplantation. 2001 Sep 27;72(6):1128-37 [11579312] Transplantation. 2001 Nov 15;72(9):1473-8 [11707732] Immunol Rev. 2001 Oct;183:214-22 [11782259] Immunol Rev. 2001 Oct;183:223-33 [11782260] J Immunol. 2002 Feb 1;168(3):1123-30 [11801646] Diabetes. 2002 Feb;51(2):265-70 [11812731] Transplantation. 2002 Mar 27;73(6):862-6 [11923684] Transplantation. 2002 Jun 15;73(11):1757-64 [12084998] Am J Transplant. 2002 Apr;2(4):381-5 [12118862] Am J Transplant. 2002 Sep;2(8):745-57 [12243495] Transplantation. 2002 Oct 15;74(7):933-40 [12394833] Transplantation. 2002 Nov 27;74(10):1365-9 [12451232] Transplantation. 2002 Nov 27;74(10):1405-9 [12451240] J Immunol. 2003 Mar 1;170(5):2776-82 [12594309] Am J Transplant. 2003 Jun;3(6):722-30 [12780564] J Clin Invest. 2003 Jun;111(12):1887-95 [12813024] Transplantation. 2003 Jun 27;75(12):2106-13 [12829920] Transplantation. 2003 Jul 15;76(1):120-9 [12865797] Transplantation. 2003 Aug 15;76(3):524-30 [12923438] Am J Transplant. 2003 Nov;3(11):1350-4 [14525594] Transpl Immunol. 2003 Oct-Nov;12(1):41-8 [14551031] Transplant Proc. 2003 Nov;35(7):2477-8 [14611990] Immunol Rev. 2003 Dec;196:147-60 [14617203] Immunol Rev. 2003 Dec;196:176-96 [14617205] Am J Transplant. 2004 Mar;4(3):378-83 [14961990] Transplantation. 2004 Feb 15;77(3):460-2 [14966427] Transplantation. 2004 Mar 27;77(6):936-9 [15077042] J Immunol. 2004 May 1;172(9):5753-64 [15100322] Transplantation. 1999 Jan 15;67(1):18-30 [9921791] J Am Soc Nephrol. 1999 Feb;10(2):374-81 [10215338] Transplant Proc. 1999 Feb-Mar;31(1-2):680 [10083292] Transplant Proc. 1999 May;31(3B Suppl):27S-28S [10330966] Nat Med. 1999 Jun;5(6):686-93 [10371508] Diabetes. 1999 Jul;48(7):1473-81 [10389857] Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8132-7 [10393960] Transplantation. 1999 Aug 27;68(4):459-67 [10480398] Am J Transplant. 2005 May;5(5):1032-41 [15816883] Transplantation. 2005 Oct 27;80(8):1051-9 [16278585] Transplant Proc. 2003 Dec;35(8):3156-9 [14698002] Transplant Proc. 1997 Sep;29(6):2546-7 [9290735] Transplant Proc. 1979 Mar;11(1):923-7 [109974] Transplantation. 1979 Oct;28(4):347-50 [116401] Surg Forum. 1979;30:282-3 [120017] Transplantation. 1980 May;29(5):401-4 [6769184] Transplantation. 1980 May;29(5):405-8 [6769185] Transplant Proc. 1981 Mar;13(1 Pt 1):434-8 [7022867] Transplantation. 1981 Dec;32(6):467-73 [7041345] Transplantation. 1983 Jul;36(1):104-6 [6346606] Folia Biol (Praha). 1983;29(3):230-7 [6347731] Ann Surg. 1983 Sep;198(3):370-8 [6351775] J Immunol. 1984 Feb;132(2):1019-25 [6228586] J Immunol. 1986 Aug 15;137(4):1127-32 [3090139] Transplantation. 1989 Feb;47(2):209-15 [2645699] Immunol Today. 1988 Jan;9(1):23-7 [3076756] Transplantation. 1989 Nov;48(5):732-41 [2573179] Surgery. 1990 Aug;108(2):406-13; discussion 413-4 [2382234] Science. 1990 Sep 14;249(4974):1293-5 [2119056] Transplantation. 1991 Jan;51(1):198-207 [1824804] Crit Rev Immunol. 1990;10(2):113-30 [1981679] Semin Immunol. 1990 Nov;2(6):401-17 [2104278] Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2585-9 [1372981] Science. 1992 Aug 7;257(5071):789-92 [1323143] Ann Surg. 1992 Oct;216(4):409-14; discussion 414-6 [1417190] Immunol Res. 1993;12(1):48-64 [8099942] Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6586-90 [7688125] Ann Surg. 1993 Oct;218(4):492-501; discussion 501-3 [8215640] Br J Surg. 1993 Nov;80(11):1389-92 [8252344] Transplantation. 1994 Jan;57(1):101-15 [8291095] Transplantation. 1994 Mar 27;57(6):788-93 [7908767] Transplantation. 1994 Apr 15;57(7):1103-10 [8165709] Transplantation. 1994 Jul 27;58(2):261-4 [7913778] Immunol Today. 1994 Jul;15(7):321-31 [7522010] Transplantation. 1995 Jan 27;59(2):256-62 [7839449] Transplantation. 1995 Jul 15;60(1):71-6 [7624946] Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9560-4 [7568172] J Urol. 1995 Dec;154(6):2197-202 [7500488] Transplantation. 1995 Nov 27;60(10):1171-8 [7482727] Nature. 1996 May 30;381(6581):434-8 [8632801] Transplantation. 1996 Jul 15;62(1):117-22 [8693525] Exp Clin Endocrinol Diabetes. 1995;103 Suppl 2:129-32 [8839269] Immunogenetics. 1997;45(3):171-9 [8995183] Transplantation. 1997 Jan 15;63(1):1-6 [9000652] Transplant Proc. 1997 Feb-Mar;29(1-2):1158 [9123249] Transplant Proc. 1997 Feb-Mar;29(1-2):1218 [9123281] Transpl Int. 1997;10(2):141-4 [9090001] Transplantation. 1997 May 15;63(9):1339-45 [9158030] Transplantation. 1997 Jul 15;64(1):124-35 [9233712] Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8789-94 [9238056] Transplant Proc. 1997 Sep;29(6):2624-5 [9290767] Transplantation. 1997 Sep 15;64(5):709-16 [9311707] Transplantation. 1997 Oct 27;64(8):1181-7 [9355837] Tissue Antigens. 1997 Dec;50(6):657-61 [9458122] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Involvement of poly(ADP-ribose) polymerase activity in regulating Chk1-dependent apoptotic cell death. AN - 68592903; 16002346 AB - The activity of poly(ADP-ribose) polymerase (PARP) is highly stimulated following DNA damage resulting in formation of DNA nicks and strand breaks. This leads to modification of numerous proteins, including itself, using NAD(+) as substrate and to exhaustion of intracellular ATP. A highly cytotoxic concentration of the DNA methylating agent methyl methanesulfonate (MMS) results in cellular ATP depletion and cell death primarily by necrosis in both wild-type and DNA polymerase beta null mouse fibroblasts. The loss of ATP can be prevented by the PARP inhibitor 4-amino-1,8-naphthalimide (4-AN), and now cells die by an energy-dependent apoptotic pathway. We find that inhibition of PARP activity transforms a sub-lethal exposure to MMS into a highly cytotoxic event. Under this condition, ATP is not depleted and cell death is by apoptosis. The caspase inhibitor, Z-VAD, shifts the mechanism of cell death to necrosis indicating a caspase-dependent component of the apoptotic cell death. Co-exposure to the Chk1 inhibitor UCN-01 also produces a decrease in apoptotic cell death, but now there is an increase in viable cells and an enhancement in long-term survival. Taken together, our results suggest that inhibition of PARP activity, induced as a result of low dose MMS exposure, signals via a Chk1-dependent pathway for cell death by apoptosis. JF - DNA repair AU - Horton, Julie K AU - Stefanick, Donna F AU - Wilson, Samuel H AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2005/09/28/ PY - 2005 DA - 2005 Sep 28 SP - 1111 EP - 1120 VL - 4 IS - 10 SN - 1568-7864, 1568-7864 KW - Amino Acid Chloromethyl Ketones KW - 0 KW - Caspase Inhibitors KW - Poly(ADP-ribose) Polymerase Inhibitors KW - benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - DNA KW - 9007-49-2 KW - Methyl Methanesulfonate KW - AT5C31J09G KW - Poly(ADP-ribose) Polymerases KW - EC 2.4.2.30 KW - Protein Kinases KW - EC 2.7.- KW - Checkpoint Kinase 1 KW - EC 2.7.11.1 KW - Chek1 protein, mouse KW - Index Medicus KW - Animals KW - Fibroblasts -- drug effects KW - Fibroblasts -- enzymology KW - Mice KW - DNA -- drug effects KW - Necrosis KW - Methyl Methanesulfonate -- toxicity KW - Cells, Cultured KW - Adenosine Triphosphate -- metabolism KW - Amino Acid Chloromethyl Ketones -- pharmacology KW - Mutation KW - Protein Kinases -- metabolism KW - Poly(ADP-ribose) Polymerases -- genetics KW - Apoptosis KW - Poly(ADP-ribose) Polymerases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68592903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+repair&rft.atitle=Involvement+of+poly%28ADP-ribose%29+polymerase+activity+in+regulating+Chk1-dependent+apoptotic+cell+death.&rft.au=Horton%2C+Julie+K%3BStefanick%2C+Donna+F%3BWilson%2C+Samuel+H&rft.aulast=Horton&rft.aufirst=Julie&rft.date=2005-09-28&rft.volume=4&rft.issue=10&rft.spage=1111&rft.isbn=&rft.btitle=&rft.title=DNA+repair&rft.issn=15687864&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-04 N1 - Date created - 2005-09-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - REV1 mediated mutagenesis in base excision repair deficient mouse fibroblast. AN - 68592824; 15950550 AB - The DNA polymerase beta (Pol beta) null background renders mouse embryonic fibroblast (MEF) cells base excision repair deficient and hyper-mutagenic upon treatment with the monofunctional alkylating agent, methyl methanesulfonate (MMS). This effect involves an increase in all types of base substitutions, with a modest predominance of G to A transitions. In the present study, we examined the hypothesis that the MMS-induced mutagenesis in the Pol beta null MEF system is due to a lesion bypass mechanism. We studied the effect of RNAi mediated down-regulation of the lesion bypass factor REV1. The steady-state level of REV1 protein was reduced by more than 95% using stable expression of a siRNA construct in a Pol beta null cell line. We found that REV1 expression is required for the MMS-induced mutagenesis phenotype of Pol beta null MEF cells. In contrast, cell survival after MMS treatment is not reduced in the absence of REV1. JF - DNA repair AU - Poltoratsky, Vladimir AU - Horton, Julie K AU - Prasad, Rajendra AU - Wilson, Samuel H AD - Laboratory of Structural Biology, NIEHS, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2005/09/28/ PY - 2005 DA - 2005 Sep 28 SP - 1182 EP - 1188 VL - 4 IS - 10 SN - 1568-7864, 1568-7864 KW - RNA, Small Interfering KW - 0 KW - Methyl Methanesulfonate KW - AT5C31J09G KW - DNA Polymerase beta KW - EC 2.7.7.- KW - Nucleotidyltransferases KW - Rev1l protein, mouse KW - Index Medicus KW - Fibroblasts -- drug effects KW - Animals KW - Methyl Methanesulfonate -- toxicity KW - Down-Regulation KW - RNA, Small Interfering -- genetics KW - Mice KW - Mutation KW - Fibroblasts -- metabolism KW - DNA Repair -- genetics KW - Nucleotidyltransferases -- metabolism KW - Nucleotidyltransferases -- genetics KW - DNA Polymerase beta -- genetics KW - Mutagenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68592824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+repair&rft.atitle=REV1+mediated+mutagenesis+in+base+excision+repair+deficient+mouse+fibroblast.&rft.au=Poltoratsky%2C+Vladimir%3BHorton%2C+Julie+K%3BPrasad%2C+Rajendra%3BWilson%2C+Samuel+H&rft.aulast=Poltoratsky&rft.aufirst=Vladimir&rft.date=2005-09-28&rft.volume=4&rft.issue=10&rft.spage=1182&rft.isbn=&rft.btitle=&rft.title=DNA+repair&rft.issn=15687864&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-04 N1 - Date created - 2005-09-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Probing Specific Lipid-Protein Interaction by Saturation Transfer Difference NMR Spectroscopy AN - 17421563; 6538465 AB - We studied the interaction of mono- and polyunsaturated phosphatidylcholines with rhodopsin by super(1)H NMR saturation transfer difference spectroscopy with magic angle spinning (STD-MAS NMR). The results indicate a strong preference for interaction of rhodopsin with the polyunsaturated docosahexaenoic acid. JF - Journal of the American Chemical Society AU - Soubias, O AU - Gawrisch, K AD - Laboratory of Membrane Biochemistry and Biophysics, NIAAA, National Institutes of Health, Bethesda, Maryland 20892, USA, gawrisch@helix.nih.gov Y1 - 2005/09/28/ PY - 2005 DA - 2005 Sep 28 SP - 13110 EP - 13111 VL - 127 IS - 38 SN - 1272-7863, 1272-7863 KW - phosphatidylcholines KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts KW - Docosahexaenoic acid KW - Rhodopsin KW - Lipids KW - Magnetic resonance spectroscopy KW - Lecithin KW - Proteins KW - N.M.R. KW - Spectroscopy KW - Spinning KW - W4 150:Medical Imaging KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17421563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Chemical+Society&rft.atitle=Probing+Specific+Lipid-Protein+Interaction+by+Saturation+Transfer+Difference+NMR+Spectroscopy&rft.au=Soubias%2C+O%3BGawrisch%2C+K&rft.aulast=Soubias&rft.aufirst=O&rft.date=2005-09-28&rft.volume=127&rft.issue=38&rft.spage=13110&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Chemical+Society&rft.issn=12727863&rft_id=info:doi/10.1021%2Fja0538942 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - N.M.R.; Rhodopsin; Spinning; Lecithin; Spectroscopy; Docosahexaenoic acid; Magnetic resonance spectroscopy; Lipids; Proteins DO - http://dx.doi.org/10.1021/ja0538942 ER - TY - JOUR T1 - LRP 1 B functions as a receptor for Pseudomonas exotoxin. AN - 68621362; 16095885 AB - Pseudomonas aeruginosa is an opportunistic pathogen that produces several virulence factors, among them Pseudomonas Exotoxin A (PE). Previously, low-density lipoprotein receptor-related protein 1 (LRP 1) was shown to be the primary receptor for PE. In this report, we show that a close family member, LRP 1B, can also function as a receptor. JF - Biochimica et biophysica acta AU - Pastrana, Diana V AU - Hanson, Alison J AU - Knisely, Jane AU - Bu, Guojun AU - Fitzgerald, David J AD - Laboratory of Molecular Biology, CCR, National Cancer Institute, Bethesda, MD 20892-4263, USA. Y1 - 2005/09/25/ PY - 2005 DA - 2005 Sep 25 SP - 234 EP - 239 VL - 1741 IS - 3 SN - 0006-3002, 0006-3002 KW - Bacterial Proteins KW - 0 KW - LRP1B protein, human KW - Membranes, Artificial KW - Polyvinyls KW - Protein Synthesis Inhibitors KW - Receptors, LDL KW - pseudomonas exoprotein A protein, Pseudomonas aeruginosa KW - polyvinylidene fluoride KW - 24937-79-9 KW - Index Medicus KW - Animals KW - Gene Transfer Techniques KW - Cricetulus KW - Electrophoresis, Polyacrylamide Gel KW - Protein Binding -- drug effects KW - Toxicity Tests KW - Mutation -- genetics KW - CHO Cells KW - Cricetinae KW - Bacterial Proteins -- toxicity KW - Protein Synthesis Inhibitors -- metabolism KW - Protein Synthesis Inhibitors -- toxicity KW - Bacterial Proteins -- genetics KW - Bacterial Proteins -- metabolism KW - Receptors, LDL -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68621362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=LRP+1+B+functions+as+a+receptor+for+Pseudomonas+exotoxin.&rft.au=Pastrana%2C+Diana+V%3BHanson%2C+Alison+J%3BKnisely%2C+Jane%3BBu%2C+Guojun%3BFitzgerald%2C+David+J&rft.aulast=Pastrana&rft.aufirst=Diana&rft.date=2005-09-25&rft.volume=1741&rft.issue=3&rft.spage=234&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-13 N1 - Date created - 2005-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Age and Results of Treatment of Atypical Glandular Cells T2 - 14th International Meeting of the European Society of Gynaecological Oncology (ESGO 14) AN - 39804247; 3987527 JF - 14th International Meeting of the European Society of Gynaecological Oncology (ESGO 14) AU - Figueiredo, E.M.A. AU - Giorgi, R AU - Magalhaes, C.M.G. AU - Moralez, G M Y1 - 2005/09/25/ PY - 2005 DA - 2005 Sep 25 KW - Oncology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39804247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+International+Meeting+of+the+European+Society+of+Gynaecological+Oncology+%28ESGO+14%29&rft.atitle=Age+and+Results+of+Treatment+of+Atypical+Glandular+Cells&rft.au=Figueiredo%2C+E.M.A.%3BGiorgi%2C+R%3BMagalhaes%2C+C.M.G.%3BMoralez%2C+G+M&rft.aulast=Figueiredo&rft.aufirst=E.M.A.&rft.date=2005-09-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+International+Meeting+of+the+European+Society+of+Gynaecological+Oncology+%28ESGO+14%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/esgo14prog/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gynecology Oncology Subspecialty Training in Brazil T2 - 14th International Meeting of the European Society of Gynaecological Oncology (ESGO 14) AN - 39742215; 3987594 JF - 14th International Meeting of the European Society of Gynaecological Oncology (ESGO 14) AU - Figueiredo, E.M.A. AU - Koch, H A AU - Moralez, G M Y1 - 2005/09/25/ PY - 2005 DA - 2005 Sep 25 KW - Brazil KW - Gynecology KW - Oncology KW - Training KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39742215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+International+Meeting+of+the+European+Society+of+Gynaecological+Oncology+%28ESGO+14%29&rft.atitle=Gynecology+Oncology+Subspecialty+Training+in+Brazil&rft.au=Figueiredo%2C+E.M.A.%3BKoch%2C+H+A%3BMoralez%2C+G+M&rft.aulast=Figueiredo&rft.aufirst=E.M.A.&rft.date=2005-09-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+International+Meeting+of+the+European+Society+of+Gynaecological+Oncology+%28ESGO+14%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/esgo14prog/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - En Block Laparoscopic Pelvic and Aortic Lymphadenectomy in Gynaecologic oncology: Experience with 90 Patients T2 - 14th International Meeting of the European Society of Gynaecological Oncology (ESGO 14) AN - 39694315; 3987833 JF - 14th International Meeting of the European Society of Gynaecological Oncology (ESGO 14) AU - Vizza, E AU - Corrado, G AU - Diotallevi, F AU - Vincenzoni, C AU - Grasso, M AU - Costaggini, I AU - Sbiroli, C Y1 - 2005/09/25/ PY - 2005 DA - 2005 Sep 25 KW - Laparoscopy KW - Oncology KW - Pelvis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39694315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+International+Meeting+of+the+European+Society+of+Gynaecological+Oncology+%28ESGO+14%29&rft.atitle=En+Block+Laparoscopic+Pelvic+and+Aortic+Lymphadenectomy+in+Gynaecologic+oncology%3A+Experience+with+90+Patients&rft.au=Vizza%2C+E%3BCorrado%2C+G%3BDiotallevi%2C+F%3BVincenzoni%2C+C%3BGrasso%2C+M%3BCostaggini%2C+I%3BSbiroli%2C+C&rft.aulast=Vizza&rft.aufirst=E&rft.date=2005-09-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+International+Meeting+of+the+European+Society+of+Gynaecological+Oncology+%28ESGO+14%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/esgo14prog/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Piver II Versus Piver III Nerve Sparing Radical Hysterectomy: Comparison of Lower Urinary Tract Dysfunctions and Morbidity T2 - 14th International Meeting of the European Society of Gynaecological Oncology (ESGO 14) AN - 39671908; 3987378 JF - 14th International Meeting of the European Society of Gynaecological Oncology (ESGO 14) AU - Raspagliesi, F AU - Ditto, A AU - Fontanelli, R AU - Hanozet, F AU - Zanaboni, F AU - Solima, E AU - Spatti, G AU - Vecchione, F AU - Rossi, G AU - Kusamura, S Y1 - 2005/09/25/ PY - 2005 DA - 2005 Sep 25 KW - Urine KW - Urinary tract KW - Morbidity KW - Nerves KW - Radicals KW - Hysterectomy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39671908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+International+Meeting+of+the+European+Society+of+Gynaecological+Oncology+%28ESGO+14%29&rft.atitle=Piver+II+Versus+Piver+III+Nerve+Sparing+Radical+Hysterectomy%3A+Comparison+of+Lower+Urinary+Tract+Dysfunctions+and+Morbidity&rft.au=Raspagliesi%2C+F%3BDitto%2C+A%3BFontanelli%2C+R%3BHanozet%2C+F%3BZanaboni%2C+F%3BSolima%2C+E%3BSpatti%2C+G%3BVecchione%2C+F%3BRossi%2C+G%3BKusamura%2C+S&rft.aulast=Raspagliesi&rft.aufirst=F&rft.date=2005-09-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+International+Meeting+of+the+European+Society+of+Gynaecological+Oncology+%28ESGO+14%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/esgo14prog/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neoadjuvant Chemotherapy with Paclitaxel, Ifosfamide and Cisplatin in Locally Advanced Cervical Cancer: Phase Ii Trial T2 - 14th International Meeting of the European Society of Gynaecological Oncology (ESGO 14) AN - 39668547; 3987520 JF - 14th International Meeting of the European Society of Gynaecological Oncology (ESGO 14) AU - Raspagliesi, F AU - Zanaboni, F AU - Vecchione , F. AU - Ditto, A AU - Hanozet, F AU - Anghileri, C AU - Kusamura, S Y1 - 2005/09/25/ PY - 2005 DA - 2005 Sep 25 KW - Cervical cancer KW - Cisplatin KW - Ifosfamide KW - Paclitaxel KW - Chemotherapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39668547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+International+Meeting+of+the+European+Society+of+Gynaecological+Oncology+%28ESGO+14%29&rft.atitle=Neoadjuvant+Chemotherapy+with+Paclitaxel%2C+Ifosfamide+and+Cisplatin+in+Locally+Advanced+Cervical+Cancer%3A+Phase+Ii+Trial&rft.au=Raspagliesi%2C+F%3BZanaboni%2C+F%3BVecchione+%2C+F.%3BDitto%2C+A%3BHanozet%2C+F%3BAnghileri%2C+C%3BKusamura%2C+S&rft.aulast=Raspagliesi&rft.aufirst=F&rft.date=2005-09-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+International+Meeting+of+the+European+Society+of+Gynaecological+Oncology+%28ESGO+14%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/esgo14prog/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sentinel Node Detection in Endometrial Cancer T2 - 14th International Meeting of the European Society of Gynaecological Oncology (ESGO 14) AN - 39667580; 3987741 JF - 14th International Meeting of the European Society of Gynaecological Oncology (ESGO 14) AU - Raspagliesi, F AU - Solima, E AU - Ditto, A AU - Hanozet, F AU - Vecchione, F AU - Anghileri, C AU - Kusamura, S Y1 - 2005/09/25/ PY - 2005 DA - 2005 Sep 25 KW - Cancer KW - Nodes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39667580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+International+Meeting+of+the+European+Society+of+Gynaecological+Oncology+%28ESGO+14%29&rft.atitle=Sentinel+Node+Detection+in+Endometrial+Cancer&rft.au=Raspagliesi%2C+F%3BSolima%2C+E%3BDitto%2C+A%3BHanozet%2C+F%3BVecchione%2C+F%3BAnghileri%2C+C%3BKusamura%2C+S&rft.aulast=Raspagliesi&rft.aufirst=F&rft.date=2005-09-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+International+Meeting+of+the+European+Society+of+Gynaecological+Oncology+%28ESGO+14%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/esgo14prog/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Photodynamic Therapy in Recurrent Vulvar Paget Disease: a Pilot Study T2 - 14th International Meeting of the European Society of Gynaecological Oncology (ESGO 14) AN - 39661434; 3987432 JF - 14th International Meeting of the European Society of Gynaecological Oncology (ESGO 14) AU - Raspagliesi, F AU - Fontanelli, R AU - Di Naro, E AU - Ditto, A AU - Solima, E AU - Vecchione, F AU - Hanozet, F AU - Rossi, G Y1 - 2005/09/25/ PY - 2005 DA - 2005 Sep 25 KW - Photodynamic therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39661434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+International+Meeting+of+the+European+Society+of+Gynaecological+Oncology+%28ESGO+14%29&rft.atitle=Photodynamic+Therapy+in+Recurrent+Vulvar+Paget+Disease%3A+a+Pilot+Study&rft.au=Raspagliesi%2C+F%3BFontanelli%2C+R%3BDi+Naro%2C+E%3BDitto%2C+A%3BSolima%2C+E%3BVecchione%2C+F%3BHanozet%2C+F%3BRossi%2C+G&rft.aulast=Raspagliesi&rft.aufirst=F&rft.date=2005-09-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+International+Meeting+of+the+European+Society+of+Gynaecological+Oncology+%28ESGO+14%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/esgo14prog/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition. AN - 68614337; 16179259 AB - The antiviral protein kinase PKR inhibits protein synthesis by phosphorylating the translation initiation factor eIF2alpha on Ser51. Binding of double-stranded RNA to the regulatory domains of PKR promotes dimerization, autophosphorylation, and the functional activation of the kinase. Herein, we identify mutations that activate PKR in the absence of its regulatory domains and map the mutations to a recently identified dimerization surface on the kinase catalytic domain. Mutations of other residues on this surface block PKR autophosphorylation and eIF2alpha phosphorylation, while mutating Thr446, an autophosphorylation site within the catalytic-domain activation segment, impairs eIF2alpha phosphorylation and viral pseudosubstrate binding. Mutational analysis of catalytic-domain residues preferentially conserved in the eIF2alpha kinase family identifies helix alphaG as critical for the specific recognition of eIF2alpha. We propose an ordered mechanism of PKR activation in which catalytic-domain dimerization triggers Thr446 autophosphorylation and specific eIF2alpha substrate recognition. JF - Cell AU - Dey, Madhusudan AU - Cao, Chune AU - Dar, Arvin C AU - Tamura, Tomohiko AU - Ozato, Keiko AU - Sicheri, Frank AU - Dever, Thomas E AD - Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2005/09/23/ PY - 2005 DA - 2005 Sep 23 SP - 901 EP - 913 VL - 122 IS - 6 SN - 0092-8674, 0092-8674 KW - Eukaryotic Initiation Factor-2 KW - 0 KW - RNA, Double-Stranded KW - eIF-2 Kinase KW - EC 2.7.11.1 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Protein Structure, Secondary KW - Saccharomyces cerevisiae -- metabolism KW - RNA, Double-Stranded -- chemistry KW - Phosphorylation KW - Dimerization KW - Protein Binding KW - RNA, Double-Stranded -- metabolism KW - Protein Conformation KW - Catalysis KW - eIF-2 Kinase -- metabolism KW - Eukaryotic Initiation Factor-2 -- metabolism KW - Eukaryotic Initiation Factor-2 -- genetics KW - eIF-2 Kinase -- genetics KW - Eukaryotic Initiation Factor-2 -- chemistry KW - eIF-2 Kinase -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68614337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell&rft.atitle=Mechanistic+link+between+PKR+dimerization%2C+autophosphorylation%2C+and+eIF2alpha+substrate+recognition.&rft.au=Dey%2C+Madhusudan%3BCao%2C+Chune%3BDar%2C+Arvin+C%3BTamura%2C+Tomohiko%3BOzato%2C+Keiko%3BSicheri%2C+Frank%3BDever%2C+Thomas+E&rft.aulast=Dey&rft.aufirst=Madhusudan&rft.date=2005-09-23&rft.volume=122&rft.issue=6&rft.spage=901&rft.isbn=&rft.btitle=&rft.title=Cell&rft.issn=00928674&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-22 N1 - Date created - 2005-09-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Cell. 2005 Sep 23;122(6):823-5 [16179248] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Second cancers among 40,576 testicular cancer patients: focus on long-term survivors. AN - 68611677; 16174857 AB - Although second primary cancers are a leading cause of death among men with testicular cancer, few studies have quantified risks among long-term survivors. Within 14 population-based tumor registries in Europe and North America (1943-2001), we identified 40,576 1-year survivors of testicular cancer and ascertained data on any new incident solid tumors among these patients. We used Poisson regression analysis to model relative risks (RRs) and excess absolute risks (EARs) of second solid cancers. All statistical tests were two-sided. A total of 2,285 second solid cancers were reported in the cohort. The relative risk and EAR decreased with increasing age at testicular cancer diagnosis (P < .001); the EAR increased with attained age (P < .001) but the excess RR decreased. Among 10-year survivors diagnosed with testicular cancer at age 35 years, the risk of developing a second solid tumor was increased (RR = 1.9, 95% confidence interval [CI] = 1.8 to 2.1). Risk remained statistically significantly elevated for 35 years (RR = 1.7, 95% CI = 1.5 to 2.0; P < .001). We observed statistically significantly elevated risks, for the first time, for cancers of the pleura (malignant mesothelioma; RR = 3.4, 95% CI = 1.7 to 5.9) and esophagus (RR = 1.7, 95% CI = 1.0 to 2.6). Cancers of the lung (RR = 1.5, 95% CI = 1.2 to 1.7), colon (RR = 2.0, 95% CI = 1.7 to 2.5), bladder (RR = 2.7, 95% CI = 2.2 to 3.1), pancreas (RR = 3.6, 95% CI = 2.8 to 4.6), and stomach (RR = 4.0, 95% CI = 3.2 to 4.8) accounted for almost 60% of the total excess. Overall patterns were similar for seminoma and nonseminoma patients, with lower risks observed for nonseminoma patients treated after 1975. Statistically significantly increased risks of solid cancers were observed among patients treated with radiotherapy alone (RR = 2.0, 95% CI = 1.9 to 2.2), chemotherapy alone (RR = 1.8, 95% CI = 1.3 to 2.5), and both (RR = 2.9, 95% CI = 1.9 to 4.2). For patients diagnosed with seminomas or nonseminomatous tumors at age 35 years, cumulative risks of solid cancer 40 years later (i.e., to age 75 years) were 36% and 31%, respectively, compared with 23% for the general population. Testicular cancer survivors are at statistically significantly increased risk of solid tumors for at least 35 years after treatment. Young patients may experience high levels of risk as they reach older ages. The statistically significantly increased risk of malignant mesothelioma in testicular cancer survivors has, to our knowledge, not been observed previously in a cohort of patients treated with radiotherapy. JF - Journal of the National Cancer Institute AU - Travis, Lois B AU - Fosså, Sophie D AU - Schonfeld, Sara J AU - McMaster, Mary L AU - Lynch, Charles F AU - Storm, Hans AU - Hall, Per AU - Holowaty, Eric AU - Andersen, Aage AU - Pukkala, Eero AU - Andersson, Michael AU - Kaijser, Magnus AU - Gospodarowicz, Mary AU - Joensuu, Timo AU - Cohen, Randi J AU - Boice, John D AU - Dores, Graça M AU - Gilbert, Ethel S AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. travisl@mail.nih.gov Y1 - 2005/09/21/ PY - 2005 DA - 2005 Sep 21 SP - 1354 EP - 1365 VL - 97 IS - 18 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Mesothelioma -- epidemiology KW - Odds Ratio KW - Urinary Bladder Neoplasms -- epidemiology KW - Humans KW - Pleural Neoplasms -- epidemiology KW - Aged KW - Poisson Distribution KW - Esophageal Neoplasms -- epidemiology KW - Antineoplastic Agents -- adverse effects KW - Risk Assessment KW - Lung Neoplasms -- epidemiology KW - North America -- epidemiology KW - Adult KW - Pancreatic Neoplasms -- epidemiology KW - Stomach Neoplasms -- epidemiology KW - Male KW - Kidney Neoplasms -- epidemiology KW - Europe -- epidemiology KW - Radiotherapy, Adjuvant -- adverse effects KW - Chemotherapy, Adjuvant -- adverse effects KW - Radiotherapy -- adverse effects KW - Registries KW - Colonic Neoplasms -- epidemiology KW - Incidence KW - Confidence Intervals KW - Middle Aged KW - Survivors -- statistics & numerical data KW - Testicular Neoplasms -- drug therapy KW - Testicular Neoplasms -- radiotherapy KW - Neoplasms, Second Primary -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68611677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Second+cancers+among+40%2C576+testicular+cancer+patients%3A+focus+on+long-term+survivors.&rft.au=Travis%2C+Lois+B%3BFoss%C3%A5%2C+Sophie+D%3BSchonfeld%2C+Sara+J%3BMcMaster%2C+Mary+L%3BLynch%2C+Charles+F%3BStorm%2C+Hans%3BHall%2C+Per%3BHolowaty%2C+Eric%3BAndersen%2C+Aage%3BPukkala%2C+Eero%3BAndersson%2C+Michael%3BKaijser%2C+Magnus%3BGospodarowicz%2C+Mary%3BJoensuu%2C+Timo%3BCohen%2C+Randi+J%3BBoice%2C+John+D%3BDores%2C+Gra%C3%A7a+M%3BGilbert%2C+Ethel+S&rft.aulast=Travis&rft.aufirst=Lois&rft.date=2005-09-21&rft.volume=97&rft.issue=18&rft.spage=1354&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-09-30 N1 - Date created - 2005-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Applied Proteomics in HCV/HIV co-infection: Differential Expression of Serum Proteins Prior to Treatment is Associated with Response to HCV Therapy in HIV Co-infected individuals. T2 - 45th Interscience Conference on Antimicrobial Agents and Chemotherapy AN - 40078585; 3986993 JF - 45th Interscience Conference on Antimicrobial Agents and Chemotherapy AU - Kottilil Y1 - 2005/09/21/ PY - 2005 DA - 2005 Sep 21 KW - Therapy KW - proteomics KW - Serum proteins KW - Hepatitis C virus KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40078585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy&rft.atitle=Applied+Proteomics+in+HCV%2FHIV+co-infection%3A+Differential+Expression+of+Serum+Proteins+Prior+to+Treatment+is+Associated+with+Response+to+HCV+Therapy+in+HIV+Co-infected+individuals.&rft.au=Kottilil&rft.aulast=Kottilil&rft.aufirst=&rft.date=2005-09-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy&rft.issn=&rft_id=info:doi/ L2 - http://www.icaac.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selective Suppression by Synthetic siRNA Duplexes of Human Papillomavirus 16 and 18 E6 and E7 Oncogene Expression T2 - 45th Interscience Conference on Antimicrobial Agents and Chemotherapy AN - 40078529; 3986979 JF - 45th Interscience Conference on Antimicrobial Agents and Chemotherapy AU - Zheng Y1 - 2005/09/21/ PY - 2005 DA - 2005 Sep 21 KW - siRNA KW - Oncogenes KW - Human papillomavirus 16 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40078529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy&rft.atitle=Selective+Suppression+by+Synthetic+siRNA+Duplexes+of+Human+Papillomavirus+16+and+18+E6+and+E7+Oncogene+Expression&rft.au=Zheng&rft.aulast=Zheng&rft.aufirst=&rft.date=2005-09-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy&rft.issn=&rft_id=info:doi/ L2 - http://www.icaac.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Antagonistic Interaction Between Amphotericin B (AB) and Ravuconazole (RAV) Using the Bliss Independence Drug Interaction (BIDI) Model: In Vitro and In Vivo Correlations T2 - 45th Interscience Conference on Antimicrobial Agents and Chemotherapy AN - 40055304; 3987021 JF - 45th Interscience Conference on Antimicrobial Agents and Chemotherapy AU - Meletiadis Y1 - 2005/09/21/ PY - 2005 DA - 2005 Sep 21 KW - Models KW - Amphotericin B KW - Drug interaction KW - ravuconazole KW - Antibodies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40055304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy&rft.atitle=Antagonistic+Interaction+Between+Amphotericin+B+%28AB%29+and+Ravuconazole+%28RAV%29+Using+the+Bliss+Independence+Drug+Interaction+%28BIDI%29+Model%3A+In+Vitro+and+In+Vivo+Correlations&rft.au=Meletiadis&rft.aulast=Meletiadis&rft.aufirst=&rft.date=2005-09-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy&rft.issn=&rft_id=info:doi/ L2 - http://www.icaac.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multi-dimensional Volumetric Imaging Method (MDVIM) in Assessment of Pulmonary Infiltrates in Response to Antifungal Therapy in Experimental Invasive Pulmonary Aspergillosis (IPA) T2 - 45th Interscience Conference on Antimicrobial Agents and Chemotherapy AN - 40045662; 3987012 JF - 45th Interscience Conference on Antimicrobial Agents and Chemotherapy AU - Petraitis Y1 - 2005/09/21/ PY - 2005 DA - 2005 Sep 21 KW - Therapy KW - Fungicides KW - Lung KW - Aspergillosis KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40045662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy&rft.atitle=Multi-dimensional+Volumetric+Imaging+Method+%28MDVIM%29+in+Assessment+of+Pulmonary+Infiltrates+in+Response+to+Antifungal+Therapy+in+Experimental+Invasive+Pulmonary+Aspergillosis+%28IPA%29&rft.au=Petraitis&rft.aulast=Petraitis&rft.aufirst=&rft.date=2005-09-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy&rft.issn=&rft_id=info:doi/ L2 - http://www.icaac.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sympathetic Noradrenergic Denervation in Parkinson Disease T2 - 59th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research in association with the Council on the Kidney in Cardiovascular Disease AN - 39710148; 4023271 JF - 59th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research in association with the Council on the Kidney in Cardiovascular Disease AU - Goldstein, David S AU - Holmes, Courtney AU - Sharabi, Yehonatan Y1 - 2005/09/21/ PY - 2005 DA - 2005 Sep 21 KW - Parkinson's disease KW - Movement disorders KW - Neurodegenerative diseases KW - Norepinephrine KW - Denervation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39710148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=59th+Annual+Fall+Conference+and+Scientific+Sessions+of+the+Council+for+High+Blood+Pressure+Research+in+association+with+the+Council+on+the+Kidney+in+Cardiovascular+Disease&rft.atitle=Sympathetic+Noradrenergic+Denervation+in+Parkinson+Disease&rft.au=Goldstein%2C+David+S%3BHolmes%2C+Courtney%3BSharabi%2C+Yehonatan&rft.aulast=Goldstein&rft.aufirst=David&rft.date=2005-09-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=59th+Annual+Fall+Conference+and+Scientific+Sessions+of+the+Council+for+High+Blood+Pressure+Research+in+association+with+the+Council+on+the+Kidney+in+Cardiovascular+Disease&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/downloadable/heart/1126889314397Final%20Progra m.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hypokalemia in Thiazide-Sensitive Na-Cl Cotransporter Knockout Mice T2 - 59th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research in association with the Council on the Kidney in Cardiovascular Disease AN - 39666364; 4023356 JF - 59th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure Research in association with the Council on the Kidney in Cardiovascular Disease AU - Morris, Ryan G AU - Hoorn, Ewout J AU - Knepper, Mark A Y1 - 2005/09/21/ PY - 2005 DA - 2005 Sep 21 KW - Mice KW - Hypokalemia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39666364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=59th+Annual+Fall+Conference+and+Scientific+Sessions+of+the+Council+for+High+Blood+Pressure+Research+in+association+with+the+Council+on+the+Kidney+in+Cardiovascular+Disease&rft.atitle=Hypokalemia+in+Thiazide-Sensitive+Na-Cl+Cotransporter+Knockout+Mice&rft.au=Morris%2C+Ryan+G%3BHoorn%2C+Ewout+J%3BKnepper%2C+Mark+A&rft.aulast=Morris&rft.aufirst=Ryan&rft.date=2005-09-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=59th+Annual+Fall+Conference+and+Scientific+Sessions+of+the+Council+for+High+Blood+Pressure+Research+in+association+with+the+Council+on+the+Kidney+in+Cardiovascular+Disease&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/downloadable/heart/1126889314397Final%20Progra m.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Phase I trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with B-cell malignancies. AN - 68594802; 16061911 AB - To conduct a phase I trial of recombinant immunotoxin BL22, an anti-CD22 Fv fragment fused to truncated Pseudomonas exotoxin. Forty-six pretreated patients with CD22+ non-Hodgkin's lymphoma (NHL; n = 4), chronic lymphocytic leukemia (CLL; n = 11), and hairy cell leukemia (HCL; n = 31) received 265 cycles at 3 to 50 microg/Kg every other day x 3 doses. BL22 was active in HCL, with 19 complete remissions (CRs; 61%) and six partial responses (PRs; 19%) in 31 patients. Of 19 CRs, 11 were achieved after one cycle and eight after two to 14 cycles. All 25 responders benefited clinically with one cycle. The CR rate was 86% in patients enrolled at > or = 40 microg/Kg every other day x 3, and 41% at lower doses (P = .011). The median duration for CR was 36 months (range, 5 to 66 months), and eight patients remain in CR at 45 months (range, 29 to 66 months). Lower but significant activity occurred in CLL. Neutralizing antibodies occurred in 11 (24%) of 46 patients (all HCL). A reversible hemolytic uremic syndrome requiring plasmapheresis was observed in one patient with NHL during cycle 1 and in four patients with HCL during cycle 2 or 3. The maximum-tolerated dose (MTD) evaluated at cycle 1 was 40 microg/Kg IV. QOD x 3. The most common toxicities at 30 to 50 microg/Kg every other day x 3 included hypoalbuminemia, transaminase elevations, fatigue, and edema. BL22 was well tolerated and highly effective in HCL, even after one cycle. Phase II testing is underway to define the efficacy with one cycle and to study safety when additional cycles are needed for optimal response. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Kreitman, Robert J AU - Squires, David R AU - Stetler-Stevenson, Maryalice AU - Noel, Pierre AU - FitzGerald, David J P AU - Wilson, Wyndham H AU - Pastan, Ira AD - Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bldg 5124b, 9000 Rockville Pike, Bethesda, MD 20892, USA. kreitmar@mail.nih.gov Y1 - 2005/09/20/ PY - 2005 DA - 2005 Sep 20 SP - 6719 EP - 6729 VL - 23 IS - 27 SN - 0732-183X, 0732-183X KW - Antibodies KW - 0 KW - Enterotoxins KW - Immunotoxins KW - RFB4(dsFv)-PE38 recombinant immunotoxin KW - Index Medicus KW - Severity of Illness Index KW - Drug Administration Schedule KW - Infusions, Intravenous KW - Dose-Response Relationship, Drug KW - Humans KW - Aged KW - Risk Assessment KW - Aged, 80 and over KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Follow-Up Studies KW - Maximum Tolerated Dose KW - Female KW - Male KW - Survival Analysis KW - Lymphoma, Non-Hodgkin -- drug therapy KW - Lymphoma, Non-Hodgkin -- diagnosis KW - Leukemia, Lymphocytic, Chronic, B-Cell -- diagnosis KW - Leukemia, Hairy Cell -- mortality KW - Lymphoma, Non-Hodgkin -- mortality KW - Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy KW - Leukemia, Hairy Cell -- drug therapy KW - Immunotoxins -- therapeutic use KW - Leukemia, Lymphocytic, Chronic, B-Cell -- mortality KW - Leukemia, Hairy Cell -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68594802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Phase+I+trial+of+recombinant+immunotoxin+RFB4%28dsFv%29-PE38+%28BL22%29+in+patients+with+B-cell+malignancies.&rft.au=Kreitman%2C+Robert+J%3BSquires%2C+David+R%3BStetler-Stevenson%2C+Maryalice%3BNoel%2C+Pierre%3BFitzGerald%2C+David+J+P%3BWilson%2C+Wyndham+H%3BPastan%2C+Ira&rft.aulast=Kreitman&rft.aufirst=Robert&rft.date=2005-09-20&rft.volume=23&rft.issue=27&rft.spage=6719&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=0732183X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-10-27 N1 - Date created - 2005-09-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cardiac-specific Nkx2.5 homeodomain: conformational stability and specific DNA binding of Nkx2.5(C56S). AN - 68584227; 16156660 AB - The cardiac-specific Nkx2.5 homeodomain has been expressed as a 79-residue protein with the oxidizable Cys(56) replaced with Ser. The Nkx2.5 or Nkx2.5(C56S) homeodomain is 73% identical in sequence to and has the same NMR structure as the vnd (ventral nervous system defective)/NK-2 homeodomain of Drosophila when bound to the same specific DNA. The thermal unfolding of Nkx2.5(C56S) at pH 6.0 or 7.4 is a reversible, two-state process with unit cooperativity, as measured by differential scanning calorimetry (DSC) and far-UV circular dichroism. Adding 100 mM NaCl to Nkx2.5(C56S) at pH 7.4 increases T(m) from 44 to 54 +/- 0.2 degrees C and DeltaH from 34 to 45 +/- 2 kcal/mol (giving a DeltaC(p) of approximately 1.2 kcal K(-)(1) mol(-)(1) for homeodomain unfolding). DSC profiles of Nkx2.5 indicate fluctuating nativelike structures at <37 degrees C. Titrations of specific 18 bp DNA with Nkx2.5(C56S) in buffer at pH 7.4 with 100 mM NaCl yield binding constants of 2-6 x 10(8) M(-)(1) from 10 to 37 degrees C and a stoichiometry of 1:1 for homeodomain binding DNA, using isothermal titration calorimetry. The DNA binding reaction of Nkx2.5 is enthalpically controlled, and the temperature dependence of DeltaH gives a DeltaC(p) of -0.18 +/- 0.01 kcal K(-)(1) mol(-)(1). This corresponds to 648 +/- 36 A(2) of buried apolar surface upon Nkx2.5(C56S) binding duplex B-DNA. Thermodynamic parameters differ for Nkx2.5 and vnd/NK-2 homeodomains binding specific DNA. Unbound NK-2 is more flexible than Nkx2.5. JF - Biochemistry AU - Fodor, Elfrieda AU - Mack, James W AU - Maeng, Jin-Soo AU - Ju, Jeong-Ho AU - Lee, Hyun Sook AU - Gruschus, James M AU - Ferretti, James A AU - Ginsburg, Ann AD - Section on Protein Chemistry, Laboratory of Biochemistry, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-8012, USA. Y1 - 2005/09/20/ PY - 2005 DA - 2005 Sep 20 SP - 12480 EP - 12490 VL - 44 IS - 37 SN - 0006-2960, 0006-2960 KW - Drosophila Proteins KW - 0 KW - Homeodomain Proteins KW - Recombinant Proteins KW - Transcription Factors KW - vnd protein, Drosophila KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Animals KW - Protein Structure, Secondary KW - Thermodynamics KW - Recombinant Proteins -- metabolism KW - Restriction Mapping KW - Protein Denaturation KW - Molecular Sequence Data KW - Calorimetry KW - Mice KW - Amino Acid Sequence KW - Recombinant Proteins -- chemistry KW - Drosophila KW - Myocardium -- metabolism KW - Amino Acid Substitution KW - Protein Conformation KW - Binding Sites KW - Drosophila Proteins -- chemistry KW - Transcription Factors -- metabolism KW - DNA -- metabolism KW - Transcription Factors -- chemistry KW - Homeodomain Proteins -- metabolism KW - Drosophila Proteins -- metabolism KW - Homeodomain Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68584227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Cardiac-specific+Nkx2.5+homeodomain%3A+conformational+stability+and+specific+DNA+binding+of+Nkx2.5%28C56S%29.&rft.au=Fodor%2C+Elfrieda%3BMack%2C+James+W%3BMaeng%2C+Jin-Soo%3BJu%2C+Jeong-Ho%3BLee%2C+Hyun+Sook%3BGruschus%2C+James+M%3BFerretti%2C+James+A%3BGinsburg%2C+Ann&rft.aulast=Fodor&rft.aufirst=Elfrieda&rft.date=2005-09-20&rft.volume=44&rft.issue=37&rft.spage=12480&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-14 N1 - Date created - 2005-09-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Barium potentiates the conditioned aversion to, but not the somatic signs of, morphine withdrawal in mice. AN - 68582210; 16122731 AB - The effect of barium, a putative blocker of G-protein-activated inwardly rectifying potassium (GIRK) channels, on naltrexone-precipitated withdrawal signs in morphine-dependent mice was investigated. Mice were chronically treated with morphine (8-45 mg/kg) for 6 days. The morphine-dependent mice were then given naltrexone (1 and 3 mg/kg), after which they showed several somatic signs of withdrawal, as well as conditioned aversion, increased cortical noradrenaline turnover, and decreased dopamine turnover in the limbic forebrain. Pretreatment with barium (1.25 and 2.5 nmol) significantly potentiated the naltrexone-precipitated conditioned aversion and augmented the decrease in dopamine turnover in the limbic forebrain. However, barium pretreatment did not affect the naltrexone-precipitated somatic signs of withdrawal and increased cortical noradrenaline turnover. These findings suggest that modification of GIRK channels may be involved in the expression of aversion to morphine withdrawal mediated through the dopaminergic system but it is not involved in the somatic signs of morphine withdrawal mediated through the noradrenergic system. JF - European journal of pharmacology AU - Sato, Mio AU - Wada, Kiyoshi AU - Funada, Masahiko AD - Section of Additive Drugs Research, Department of Drug Dependence Research, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-higashi, Kodaira, Tokyo 187-8502, Japan. Y1 - 2005/09/20/ PY - 2005 DA - 2005 Sep 20 SP - 215 EP - 222 VL - 519 IS - 3 SN - 0014-2999, 0014-2999 KW - Narcotic Antagonists KW - 0 KW - Barium KW - 24GP945V5T KW - Naltrexone KW - 5S6W795CQM KW - Morphine KW - 76I7G6D29C KW - Dopamine KW - VTD58H1Z2X KW - Norepinephrine KW - X4W3ENH1CV KW - Index Medicus KW - Animals KW - Cerebral Cortex -- drug effects KW - Mice, Inbred ICR KW - Substance Withdrawal Syndrome -- physiopathology KW - Prosencephalon -- metabolism KW - Cerebral Cortex -- metabolism KW - Substance Withdrawal Syndrome -- prevention & control KW - Dose-Response Relationship, Drug KW - Dopamine -- metabolism KW - Mice KW - Behavior, Animal -- drug effects KW - Norepinephrine -- metabolism KW - Prosencephalon -- drug effects KW - Naltrexone -- pharmacology KW - Drug Synergism KW - Narcotic Antagonists -- pharmacology KW - Male KW - Conditioning, Operant -- drug effects KW - Morphine -- toxicity KW - Barium -- pharmacology KW - Morphine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68582210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+pharmacology&rft.atitle=Barium+potentiates+the+conditioned+aversion+to%2C+but+not+the+somatic+signs+of%2C+morphine+withdrawal+in+mice.&rft.au=Sato%2C+Mio%3BWada%2C+Kiyoshi%3BFunada%2C+Masahiko&rft.aulast=Sato&rft.aufirst=Mio&rft.date=2005-09-20&rft.volume=519&rft.issue=3&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=European+journal+of+pharmacology&rft.issn=00142999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-10-25 N1 - Date created - 2005-09-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Polymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, China. AN - 68070858; 15849729 AB - The lung cancer mortality rate in Xuan Wei County is among the highest in China and has been attributed to exposure to indoor smoky coal emissions that contain very high levels of polycyclic aromatic hydrocarbons (PAHs). Nucleotide excision repair (NER) plays a key role in reversing DNA damage from exposure to environmental carcinogens, such as PAHs, that form bulky DNA adducts. We studied single nucleotide polymorphisms (SNPs) and their corresponding haplotypes in 6 genes (ERCC1, ERCC2/XPD, ERCC4/XPF, ERCC5/XPG, RAD23B and XPC) involved in NER in a population-based case-control study of lung cancer in Xuan Wei. A total of 122 incident primary lung cancer cases and 122 individually matched controls were enrolled. Three linked SNPs in ERCC2 were associated with lung cancer with similar ORs; e.g., persons with the Gln allele at codon 751 had a 60% reduction of lung cancer (OR = 0.40, 95% CI 0.18-0.89). Moreover, one haplotype in ERCC2 was associated with a decreased risk of lung cancer (OR = 0.40, 95% CI 0.19-0.85) compared to the most common haplotype. In addition, subjects with one or 2 copies of the Val allele at codon 249 of RAD23B had a 2-fold increased risk of lung cancer (OR = 1.91, 95% CI 1.12-3.24). In summary, our results suggest that genetic variants in genes involved in the NER pathway may play a role in lung cancer susceptibility in Xuan Wei. However, due to the small sample size, additional studies are needed to evaluate these associations within Xuan Wei and in other populations with substantial environmental exposure to PAHs. (c) 2005 Wiley-Liss, Inc. JF - International journal of cancer AU - Shen, Min AU - Berndt, Sonja I AU - Rothman, Nathaniel AU - Demarini, David M AU - Mumford, Judy L AU - He, Xingzhou AU - Bonner, Matthew R AU - Tian, Linwei AU - Yeager, Meredith AU - Welch, Robert AU - Chanock, Stephen AU - Zheng, Tongzhang AU - Caporaso, Neil AU - Lan, Qing AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7240, USA. shenmi@mail.nih.gov Y1 - 2005/09/20/ PY - 2005 DA - 2005 Sep 20 SP - 768 EP - 773 VL - 116 IS - 5 SN - 0020-7136, 0020-7136 KW - DNA excision repair protein ERCC-5 KW - 0 KW - DNA-Binding Proteins KW - Nuclear Proteins KW - RAD23B protein, human KW - Transcription Factors KW - xeroderma pigmentosum group F protein KW - RAD23A protein, human KW - 156533-33-4 KW - XPC protein, human KW - 156533-34-5 KW - ERCC1 protein, human KW - EC 3.1.- KW - Endonucleases KW - DNA Helicases KW - EC 3.6.4.- KW - Xeroderma Pigmentosum Group D Protein KW - EC 3.6.4.12 KW - ERCC2 protein, human KW - EC 5.99.- KW - DNA Repair Enzymes KW - EC 6.5.1.- KW - Index Medicus KW - Nuclear Proteins -- genetics KW - Humans KW - DNA-Binding Proteins -- genetics KW - Aged KW - Endonucleases -- genetics KW - Transcription Factors -- genetics KW - Linkage Disequilibrium KW - Risk KW - Adult KW - Case-Control Studies KW - DNA Helicases -- genetics KW - Middle Aged KW - Female KW - Male KW - DNA Repair -- genetics KW - Polymorphism, Single Nucleotide KW - Lung Neoplasms -- etiology KW - Lung Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68070858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Polymorphisms+in+the+DNA+nucleotide+excision+repair+genes+and+lung+cancer+risk+in+Xuan+Wei%2C+China.&rft.au=Shen%2C+Min%3BBerndt%2C+Sonja+I%3BRothman%2C+Nathaniel%3BDemarini%2C+David+M%3BMumford%2C+Judy+L%3BHe%2C+Xingzhou%3BBonner%2C+Matthew+R%3BTian%2C+Linwei%3BYeager%2C+Meredith%3BWelch%2C+Robert%3BChanock%2C+Stephen%3BZheng%2C+Tongzhang%3BCaporaso%2C+Neil%3BLan%2C+Qing&rft.aulast=Shen&rft.aufirst=Min&rft.date=2005-09-20&rft.volume=116&rft.issue=5&rft.spage=768&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-09-01 N1 - Date created - 2005-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Frontiers in Research with Bioactive Food Components, the Omics and Cancer: Perspectives from the National Cancer Institute T2 - 18th International Nutrition Congress (NUTRITION SAFARI 2005) AN - 39732042; 3985902 JF - 18th International Nutrition Congress (NUTRITION SAFARI 2005) AU - Milner, John Y1 - 2005/09/19/ PY - 2005 DA - 2005 Sep 19 KW - Food KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39732042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+International+Nutrition+Congress+%28NUTRITION+SAFARI+2005%29&rft.atitle=Frontiers+in+Research+with+Bioactive+Food+Components%2C+the+Omics+and+Cancer%3A+Perspectives+from+the+National+Cancer+Institute&rft.au=Milner%2C+John&rft.aulast=Milner&rft.aufirst=John&rft.date=2005-09-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+International+Nutrition+Congress+%28NUTRITION+SAFARI+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.puk.ac.za/fakulteite/voeding/iuns/scientific%20programme.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Opportunities for International Research Collaboration in Maternal and Child Health: NICHD International Nutrition Interests, Mechanisms, and Capacity Building T2 - 18th International Nutrition Congress (NUTRITION SAFARI 2005) AN - 39672340; 3985903 JF - 18th International Nutrition Congress (NUTRITION SAFARI 2005) AU - Raiten, Dan Y1 - 2005/09/19/ PY - 2005 DA - 2005 Sep 19 KW - Nutrition KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39672340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=18th+International+Nutrition+Congress+%28NUTRITION+SAFARI+2005%29&rft.atitle=Opportunities+for+International+Research+Collaboration+in+Maternal+and+Child+Health%3A+NICHD+International+Nutrition+Interests%2C+Mechanisms%2C+and+Capacity+Building&rft.au=Raiten%2C+Dan&rft.aulast=Raiten&rft.aufirst=Dan&rft.date=2005-09-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=18th+International+Nutrition+Congress+%28NUTRITION+SAFARI+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.puk.ac.za/fakulteite/voeding/iuns/scientific%20programme.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Differential Metabolism of 2-Amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhlP) in Mice Humanized for CYP1A1 and CYP1A2 AN - 17471971; 6674237 AB - The procarcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the most abundant heterocyclic amine formed during the cooking of foods. Metabolism of PhIP by CYP1A2 differs substantially between humans and rodents, with more N super(2)-hydroxylation (activation) and less 4'-hydroxylation (detoxication) in humans. Therefore, the human response to PhIP and other heterocyclic amine exposure may not be accurately reflected in the laboratory rodent. By generating mouse models expressing the human genes, species differences in heterocyclic amine metabolism can be addressed. Two transgenic mouse lines were developed, one expressing the human CYP1A1 CYP1A2 transgene in a mouse Cyplal-null background (hCYPlAl) and another expressing human CYP1A1 CYP1A2 in a mouse Cypla2-null background (hCYPIA2). Expression of human CYP1A2 protein was detected in the liver and also at considerably lower levels in extrahepatic tissues such as lung, kidney, colon, and heart. In the hCYPlAl and HCYP1A2 mice, 3-methylcholanthrene (3-MC) induced both human CYP1A1 and CYP1A2 protein in the liver. Differences in the metabolism of the heterocyclic amine PhIP were observed between wild-type and hCYPlA2 mice. PhIP was preferentially metabolized by N super(2)-hydroxylation in hCYPlA2 mice, whereas in wild-type mice, 4'-hydroxylation was the predominant pathway. Since the N super(2)-hydroxylation pathway for PhIP metabolism has been reported to be predominant in humans, these results illustrate the potential effectiveness of using these transgenic, humanized mice as models for determining human health risks to PhIP and other heterocyclic amines instead of wild-type mice. JF - Chemical Research in Toxicology AU - Cheung, C AU - Ma, X AU - Krausz, K W AU - Kimura, S AU - Feigenbaum, L AU - Dalton, T P AU - Nebert, D W AU - Idle, J R AU - Gonzalez, F J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2005/09/19/ PY - 2005 DA - 2005 Sep 19 SP - 1471 EP - 1478 VL - 18 IS - 9 SN - 0893-228X, 0893-228X KW - Toxicology Abstracts KW - Heart KW - Heterocyclic amines KW - CYP1A2 protein KW - 3-Methylcholanthrene KW - Transgenic mice KW - Colon KW - Lung KW - Cooking KW - Liver KW - Kidney KW - Cytochrome P450 KW - Metabolism KW - X 24153:Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17471971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Research+in+Toxicology&rft.atitle=Differential+Metabolism+of+2-Amino-1-methyl-6-phenylimidazo+%5B4%2C5-b%5Dpyridine+%28PhlP%29+in+Mice+Humanized+for+CYP1A1+and+CYP1A2&rft.au=Cheung%2C+C%3BMa%2C+X%3BKrausz%2C+K+W%3BKimura%2C+S%3BFeigenbaum%2C+L%3BDalton%2C+T+P%3BNebert%2C+D+W%3BIdle%2C+J+R%3BGonzalez%2C+F+J&rft.aulast=Cheung&rft.aufirst=C&rft.date=2005-09-19&rft.volume=18&rft.issue=9&rft.spage=1471&rft.isbn=&rft.btitle=&rft.title=Chemical+Research+in+Toxicology&rft.issn=0893228X&rft_id=info:doi/10.1021%2Ftx050136g LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Heart; Heterocyclic amines; CYP1A2 protein; Colon; Lung; Cooking; Kidney; 3-Methylcholanthrene; Liver; Cytochrome P450; Transgenic mice; Metabolism DO - http://dx.doi.org/10.1021/tx050136g ER - TY - CPAPER T1 - Understanding the Simple Complexities of Drug Resistance T2 - Second International Meeting on Tumor Progression and Therapeutic Resistance (TPTR 2005) AN - 39704401; 4016892 JF - Second International Meeting on Tumor Progression and Therapeutic Resistance (TPTR 2005) AU - Fojo, Tito Y1 - 2005/09/18/ PY - 2005 DA - 2005 Sep 18 KW - Drug resistance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39704401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+International+Meeting+on+Tumor+Progression+and+Therapeutic+Resistance+%28TPTR+2005%29&rft.atitle=Understanding+the+Simple+Complexities+of+Drug+Resistance&rft.au=Fojo%2C+Tito&rft.aulast=Fojo&rft.aufirst=Tito&rft.date=2005-09-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+International+Meeting+on+Tumor+Progression+and+Therapeutic+Resistance+%28TPTR+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://gtcbio.com/ebrochure/tptr.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biomarkers and Imaging Endpoints to Accelerate Oncologic Drug Development T2 - Second International Meeting on Tumor Progression and Therapeutic Resistance (TPTR 2005) AN - 39644004; 4016906 JF - Second International Meeting on Tumor Progression and Therapeutic Resistance (TPTR 2005) AU - Kelloff, Gary Y1 - 2005/09/18/ PY - 2005 DA - 2005 Sep 18 KW - Biomarkers KW - Drug development KW - Bioindicators KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39644004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+International+Meeting+on+Tumor+Progression+and+Therapeutic+Resistance+%28TPTR+2005%29&rft.atitle=Biomarkers+and+Imaging+Endpoints+to+Accelerate+Oncologic+Drug+Development&rft.au=Kelloff%2C+Gary&rft.aulast=Kelloff&rft.aufirst=Gary&rft.date=2005-09-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+International+Meeting+on+Tumor+Progression+and+Therapeutic+Resistance+%28TPTR+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://gtcbio.com/ebrochure/tptr.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Survey of oxaliplatin-associated neurotoxicity using an interview-based questionnaire in patients with metastatic colorectal cancer. AN - 68725793; 16168057 AB - New chemotherapy regimens for patients with colorectal cancer have improved survival, but at the cost of clinical toxicity. Oxaliplatin, an agent used in first-line therapy for metastatic colorectal cancer, causes acute and chronic neurotoxicity. This study was performed to carefully assess the incidence, type and duration of oxaliplatin neurotoxicity. A detailed questionnaire was completed after each chemotherapy cycle for patients with metastatic colorectal cancer enrolled in a phase I trial of oxaliplatin and capecitabine. An oxaliplatin specific neurotoxicity scale was used to grade toxicity. Eighty-six adult patients with colorectal cancer were evaluated. Acute neuropathy symptoms included voice changes, visual alterations, pharyngo-laryngeal dysesthesia (lack of awareness of breathing); peri-oral or oral numbness, pain and symptoms due to muscle contraction (spasm, cramps, tremors). When the worst neurotoxicity per patient was considered, grade 1/2/3/4 dysesthesias and paresthesias were seen in 71/12/5/0 and 66/20/7/1 percent of patients. By cycles 3, 6, 9, and 12, oxaliplatin dose reduction or discontinuation was needed in 2.7%, 20%, 37.5% and 62.5% of patients. Oxaliplatin-associated acute neuropathy causes a variety of distressing, but transient, symptoms due to peripheral sensory and motor nerve hyperexcitability. Chronic neuropathy may be debilitating and often necessitates dose reductions or discontinuation of oxaliplatin. Patients should be warned of the possible spectrum of symptoms and re-assured about the transient nature of acute neurotoxicity. Ongoing studies are addressing the treatment and prophylaxis of oxaliplatin neurotoxicity. JF - BMC cancer AU - Leonard, Gregory D AU - Wright, Maurice A AU - Quinn, Mary G AU - Fioravanti, Suzanne AU - Harold, Nancy AU - Schuler, Barbara AU - Thomas, Rebecca R AU - Grem, Jean L AD - Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, National Naval Medical Center, Bethesda, MD 20889-5105, USA. LeonardG@Sehb.ie Y1 - 2005/09/16/ PY - 2005 DA - 2005 Sep 16 SP - 116 VL - 5 KW - Antimetabolites, Antineoplastic KW - 0 KW - Antineoplastic Agents KW - Organoplatinum Compounds KW - oxaliplatin KW - 04ZR38536J KW - Deoxycytidine KW - 0W860991D6 KW - Capecitabine KW - 6804DJ8Z9U KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Antimetabolites, Antineoplastic -- adverse effects KW - Humans KW - Paresthesia -- chemically induced KW - Clinical Trials as Topic KW - Aged KW - Antimetabolites, Antineoplastic -- pharmacology KW - Antineoplastic Agents -- adverse effects KW - Adult KW - Fluorouracil -- analogs & derivatives KW - Treatment Outcome KW - Surveys and Questionnaires KW - Neoplasm Metastasis KW - Middle Aged KW - Time Factors KW - Antineoplastic Agents -- pharmacology KW - Neurotoxicity Syndromes -- pathology KW - Female KW - Male KW - Organoplatinum Compounds -- adverse effects KW - Organoplatinum Compounds -- pharmacology KW - Deoxycytidine -- adverse effects KW - Colorectal Neoplasms -- pathology KW - Deoxycytidine -- analogs & derivatives KW - Deoxycytidine -- pharmacology KW - Colorectal Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68725793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+cancer&rft.atitle=Survey+of+oxaliplatin-associated+neurotoxicity+using+an+interview-based+questionnaire+in+patients+with+metastatic+colorectal+cancer.&rft.au=Leonard%2C+Gregory+D%3BWright%2C+Maurice+A%3BQuinn%2C+Mary+G%3BFioravanti%2C+Suzanne%3BHarold%2C+Nancy%3BSchuler%2C+Barbara%3BThomas%2C+Rebecca+R%3BGrem%2C+Jean+L&rft.aulast=Leonard&rft.aufirst=Gregory&rft.date=2005-09-16&rft.volume=5&rft.issue=&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=BMC+cancer&rft.issn=1471-2407&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-27 N1 - Date created - 2005-10-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Colorectal Cancer. 2002 May;2(1):54-8 [12453338] Semin Oncol. 2002 Oct;29(5 Suppl 15):21-33 [12422305] J Clin Oncol. 2003 Jun 1;21(11):2059-69 [12775730] Clin Colorectal Cancer. 2003 Aug;3(2):121-3 [12952569] Ann Oncol. 2003 Sep;14(9):1378-82 [12954576] Semin Oncol. 2003 Aug;30(4 Suppl 15):5-13 [14523789] J Clin Oncol. 2004 Jan 1;22(1):23-30 [14665611] J Clin Oncol. 2004 Jan 15;22(2):229-37 [14657227] Cancer. 2004 Feb 1;100(3):531-7 [14745869] CA Cancer J Clin. 2004 Jan-Feb;54(1):8-29 [14974761] Muscle Nerve. 2004 Mar;29(3):387-92 [14981738] J Clin Oncol. 2004 Jun 1;22(11):2084-91 [15169795] N Engl J Med. 2004 Jun 3;350(23):2343-51 [15175436] Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):4055-61 [15217938] Anticancer Drugs. 2004 Aug;15(7):733-5 [15269607] Anticancer Drugs. 2004 Sep;15(8):767-71 [15494638] J Natl Cancer Inst. 1994 Nov 2;86(21):1608-17 [7932825] Am J Clin Oncol. 1998 Jun;21(3):248-9 [9626791] Toxicol Sci. 1998 Dec;46(2):342-51 [10048138] Ann Oncol. 1999 Jun;10(6):663-9 [10442188] Ann Oncol. 1999 Sep;10(9):1125-8 [10572615] J Clin Oncol. 2000 Jan;18(1):136-47 [10623704] J Clin Oncol. 2000 Aug;18(16):2938-47 [10944126] Oncology (Williston Park). 2000 Dec;14(12 Suppl 11):33-7 [11204661] Ann Oncol. 2001 Mar;12(3):421-2 [11332158] J Neurophysiol. 2001 May;85(5):2293-7 [11353042] Anticancer Drugs. 2001 Jul;12(6):525-31 [11459999] Eur J Cancer. 2001 Dec;37(18):2457-63 [11720843] J Clin Oncol. 2002 Apr 1;20(7):1759-66 [11919232] J Clin Oncol. 2002 Apr 1;20(7):1767-74 [11919233] J Clin Oncol. 2002 Apr 15;20(8):2031-7 [11956262] Ann Oncol. 2002 May;13(5):716-20 [12075739] J Clin Oncol. 2002 Aug 1;20(15):3359-61 [12149316] J Clin Oncol. 2002 Aug 15;20(16):3478-83 [12177109] J Clin Oncol. 2003 Apr 1;21(7):1307-12 [12663719] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The synaptic localization of NR2B-containing NMDA receptors is controlled by interactions with PDZ proteins and AP-2. AN - 68583684; 16157279 AB - The NMDA receptor (NMDAR) is a component of excitatory synapses and a key participant in synaptic plasticity. We investigated the role of two domains in the C terminus of the NR2B subunit--the PDZ binding domain and the clathrin adaptor protein (AP-2) binding motif--in the synaptic localization of NMDA receptors. NR2B subunits lacking functional PDZ binding are excluded from the synapse. Mutations in the AP-2 binding motif, YEKL, significantly increase the number of synaptic receptors and allow the synaptic localization of NR2B subunits lacking PDZ binding. Peptides corresponding to YEKL increase the synaptic response within minutes. In contrast, the NR2A subunit localizes to the synapse in the absence of PDZ binding and is not altered by mutations in its motif corresponding to YEKL of NR2B. This study identifies a dynamic regulation of synaptic NR2B-containing NMDARs through PDZ protein-mediated stabilization and AP-2-mediated internalization that is modulated by phosphorylation by Fyn kinase. JF - Neuron AU - Prybylowski, Kate AU - Chang, Kai AU - Sans, Nathalie AU - Kan, Lilly AU - Vicini, Stefano AU - Wenthold, Robert J AD - Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, Room 4148/Bldg. 50, National Institutes of Health, Bethesda Maryland 20892, USA. prybylow@nidcd.nih.gov Y1 - 2005/09/15/ PY - 2005 DA - 2005 Sep 15 SP - 845 EP - 857 VL - 47 IS - 6 SN - 0896-6273, 0896-6273 KW - DNA Probes KW - 0 KW - NR2B NMDA receptor KW - Nerve Tissue Proteins KW - Receptors, N-Methyl-D-Aspartate KW - Tyrosine KW - 42HK56048U KW - Index Medicus KW - Animals KW - Fluorescent Antibody Technique -- methods KW - Two-Hybrid System Techniques KW - Mutagenesis -- physiology KW - Amino Acid Sequence KW - Blotting, Western -- methods KW - Rats KW - Animals, Newborn KW - Cerebellum -- cytology KW - Amino Acid Motifs -- physiology KW - Transfection KW - Mutation -- physiology KW - Cells, Cultured KW - DNA Probes -- physiology KW - Immunoprecipitation -- methods KW - Tyrosine -- metabolism KW - Models, Neurological KW - Time Factors KW - Excitatory Postsynaptic Potentials -- physiology KW - Neurons -- physiology KW - Nerve Tissue Proteins -- metabolism KW - Receptors, N-Methyl-D-Aspartate -- metabolism KW - Synapses -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68583684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuron&rft.atitle=The+synaptic+localization+of+NR2B-containing+NMDA+receptors+is+controlled+by+interactions+with+PDZ+proteins+and+AP-2.&rft.au=Prybylowski%2C+Kate%3BChang%2C+Kai%3BSans%2C+Nathalie%3BKan%2C+Lilly%3BVicini%2C+Stefano%3BWenthold%2C+Robert+J&rft.aulast=Prybylowski&rft.aufirst=Kate&rft.date=2005-09-15&rft.volume=47&rft.issue=6&rft.spage=845&rft.isbn=&rft.btitle=&rft.title=Neuron&rft.issn=08966273&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-07 N1 - Date created - 2005-09-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuron. 2002 Oct 24;36(3):435-49 [12408846] J Neurosci. 2002 Oct 15;22(20):8902-10 [12388597] Trends Neurosci. 2003 Feb;26(2):81-9 [12536131] Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1340-5 [12552130] Nat Neurosci. 2003 Mar;6(3):231-42 [12577062] Nature. 2003 Mar 20;422(6929):302-7 [12646920] J Biol Chem. 2003 Mar 28;278(13):11020-5 [12536146] Nat Rev Neurosci. 2003 Apr;4(4):251-65 [12671642] Annu Rev Biochem. 2003;72:395-447 [12651740] Neuropharmacology. 2003 Nov;45(6):729-37 [14529712] Eur J Neurosci. 2003 Dec;18(12):3207-17 [14686895] Cell Struct Funct. 2003 Oct;28(5):419-29 [14745134] J Biol Chem. 2004 Mar 12;279(11):9673-6 [14742424] J Neurosci. 1997 Jan 1;17(1):107-16 [8987740] Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4761-5 [9114065] Neuron. 1997 Oct;19(4):801-12 [9354327] Science. 1998 Nov 13;282(5392):1327-32 [9812899] Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):435-40 [9892651] EMBO J. 1999 May 4;18(9):2489-99 [10228163] J Neurosci. 1999 May 15;19(10):4180-8 [10234045] J Biol Chem. 1999 Sep 17;274(38):27211-8 [10480938] J Neurosci. 2004 Nov 10;24(45):10248-59 [15537897] Science. 2004 May 14;304(5673):1021-4 [15143284] Curr Opin Neurobiol. 2004 Jun;14(3):353-61 [15194116] J Neurosci. 2004 Jul 14;24(28):6383-91 [15254094] Nat Neurosci. 2004 Sep;7(9):917-8 [15322548] J Biol Chem. 1996 Jun 7;271(23):13297-9 [8663153] Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10452-6 [8816821] Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10457-60 [8816822] J Physiol. 1996 Apr 15;492 ( Pt 2):445-52 [9019541] Neuron. 1999 Nov;24(3):649-58 [10595516] J Neurosci. 1999 Dec 15;19(24):10603-10 [10594044] J Neurosci. 2000 Feb 1;20(3):1260-71 [10648730] J Neurosci. 2000 Jun 15;20(12):4573-81 [10844027] Neuron. 2000 Jun;26(3):659-70 [10896161] Nat Neurosci. 2000 Dec;3(12):1282-90 [11100149] J Biol Chem. 2001 Jan 5;276(1):693-9 [11024032] Neuron. 2000 Nov;28(2):511-25 [11144360] Neuron. 2001 Jan;29(1):157-69 [11182088] Nat Rev Neurosci. 2000 Nov;1(2):133-41 [11252776] Nat Neurosci. 2001 Jun;4(6):587-96 [11369939] Curr Opin Neurobiol. 2001 Jun;11(3):327-35 [11399431] Curr Opin Neurobiol. 2001 Jun;11(3):336-42 [11399432] J Neurosci. 2001 Jul 15;21(14):5079-88 [11438583] J Neurosci. 2001 Aug 1;21(15):5546-58 [11466426] Nat Neurosci. 2001 Aug;4(8):794-802 [11477425] Nat Neurosci. 2001 Nov;4(11):1079-85 [11687813] Science. 2002 Jan 18;295(5554):491-5 [11799243] J Neurochem. 2002 Feb;80(4):589-97 [11841566] J Biol Chem. 2002 Feb 22;277(8):5699-702 [11741967] Neuron. 2002 Feb 28;33(5):765-77 [11879653] Neuron. 2002 Apr 11;34(2):255-64 [11970867] Annu Rev Neurosci. 2002;25:103-26 [12052905] J Biol Chem. 2002 Jun 14;277(24):21697-711 [11937501] J Neurosci. 2002 Jul 15;22(14):6208-17 [12122079] Neuron. 2002 Jul 18;35(2):345-53 [12160751] Nat Neurosci. 2002 Sep;5(9):833-4 [12195433] Neuron. 2002 Nov 14;36(4):661-74 [12441055] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fixed dose-rate gemcitabine infusion as first-line treatment for advanced-stage carcinoma of the pancreas and biliary tree. AN - 68556690; 16078261 AB - Gemcitabine infusion at the fixed dose rate of 10 mg/m(2) per minute (FDR-gemcitabine) has pharmacokinetic advantages and may result in improved therapeutic efficacy. Between April 2002 and September 2003, 40 patients with advanced-stage pancreatic adenocarcinoma (PDAC; n = 27) or biliary tree carcinoma (BTC; n = 13) were treated with weekly FDR-gemcitabine (1000 mg/m(2)). The primary end point was the response rate. The secondary end points were progression-free and overall survival (PFS and OS), tumor marker response, and clinical benefit response (CBR). The overall response rate (ORR) on an intent-to-treat basis was 15% (95% confidence interval [95% CI], 4-26%). A positive CBR was obtained in 14 of 29 (48%) patients. Seventeen of 25 (68%) patients had a reduction in carbohydrate antigen 19-9 (CA 19-9) of > 25%. The median time to treatment failure and the median PFS were 17 weeks (95% CI, 13-22 weeks) and 19 weeks (95% CI, 15-23 weeks), respectively. The median OS was 40 weeks (95% CI, 36-45 weeks) and the 1-year actuarial survival rate was 25.8%. Multivariate analysis showed that a performance status score of 0-1 at study entry and locally advanced disease were the only independent predictors of longer PFS and OS, whereas a reduction in CA 19-9 serum levels > 75% was an independent predictor of longer PFS, but had no impact on OS. Toxicity was mild with Grade 3-4 neutropenia (according to the National Cancer Institute-Common Toxicity Criteria [version 2.0]) in 18 of 427 treatment weeks (4.2%), and Grade 3 anemia and thrombocytopenia in 6 of 427 treatment weeks (1.4%) and 9 of 427 treatment weeks (2.1%), respectively, and asymptomatic Grade 3-4 transaminase elevation in 21 of 427 treatment weeks (4.9%). FDR-gemcitabine at the weekly dose of 1000 mg/m(2) demonstrated promising activity, despite negligible toxicity, in patients with advanced-stage PDAC and BTC. Copyright 2005 American Cancer Society. JF - Cancer AU - Gelibter, Alain AU - Malaguti, Paola AU - Di Cosimo, Serena AU - Bria, Emilio AU - Ruggeri, Enzo Maria AU - Carlini, Paolo AU - Carboni, Fabio AU - Ettorre, Giuseppe Maria AU - Pellicciotta, Mario AU - Giannarelli, Diana AU - Terzoli, Edmondo AU - Cognetti, Francesco AU - Milella, Michele AD - Division of Medical Oncology A, Regina Elena National Cancer Institute, Rome, Italy. Y1 - 2005/09/15/ PY - 2005 DA - 2005 Sep 15 SP - 1237 EP - 1245 VL - 104 IS - 6 SN - 0008-543X, 0008-543X KW - CA-19-9 Antigen KW - 0 KW - Deoxycytidine KW - 0W860991D6 KW - gemcitabine KW - B76N6SBZ8R KW - Abridged Index Medicus KW - Index Medicus KW - CA-19-9 Antigen -- blood KW - Survival Rate KW - Humans KW - Male KW - Female KW - Pancreatic Neoplasms -- mortality KW - Deoxycytidine -- adverse effects KW - Deoxycytidine -- analogs & derivatives KW - Deoxycytidine -- therapeutic use KW - Deoxycytidine -- administration & dosage KW - Pancreatic Neoplasms -- drug therapy KW - Biliary Tract Neoplasms -- mortality KW - Adenocarcinoma -- drug therapy KW - Biliary Tract Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68556690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Fixed+dose-rate+gemcitabine+infusion+as+first-line+treatment+for+advanced-stage+carcinoma+of+the+pancreas+and+biliary+tree.&rft.au=Gelibter%2C+Alain%3BMalaguti%2C+Paola%3BDi+Cosimo%2C+Serena%3BBria%2C+Emilio%3BRuggeri%2C+Enzo+Maria%3BCarlini%2C+Paolo%3BCarboni%2C+Fabio%3BEttorre%2C+Giuseppe+Maria%3BPellicciotta%2C+Mario%3BGiannarelli%2C+Diana%3BTerzoli%2C+Edmondo%3BCognetti%2C+Francesco%3BMilella%2C+Michele&rft.aulast=Gelibter&rft.aufirst=Alain&rft.date=2005-09-15&rft.volume=104&rft.issue=6&rft.spage=1237&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-10-27 N1 - Date created - 2005-09-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Maternal serum levels of polychlorinated biphenyls and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and time to pregnancy. AN - 68538714; 16093292 AB - Polychlorinated biphenyls (PCBs), once used widely in transformers and other applications, and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), the main metabolite of the pesticide 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), are hormonally active agents. Changes in menstrual cycle functioning associated with PCBs and DDE, and increased odds of spontaneous abortion associated with DDE, suggest that these compounds could affect fertility. The authors investigated the association between PCB and DDE exposure and time to pregnancy by using serum levels measured in 390 pregnant women in the Collaborative Perinatal Project enrolled at 12 study centers in the United States from 1959 to 1965. They estimated adjusted fecundability odds ratios by using Cox proportional hazards modeling for discrete time data. Compared with time to pregnancy for women in the lowest exposure category (PCBs or = 5.00 microg/liter = 0.65, 95% confidence interval: 0.36, 1.18) and DDE (fecundability odds ratio for DDE > or = 60 microg/liter = 0.65, 95% confidence interval: 0.32, 1.31). Overall, time to pregnancy increased with increasing serum PCB levels but was less suggestive of an association with DDE. Both trends were imprecise and attenuated when expressed on a lipid basis. Overall, evidence of an association between PCB or DDE exposure and time to pregnancy was weak and inconclusive. JF - American journal of epidemiology AU - Law, Dionne C Gesink AU - Klebanoff, Mark A AU - Brock, John W AU - Dunson, David B AU - Longnecker, Matthew P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2005/09/15/ PY - 2005 DA - 2005 Sep 15 SP - 523 EP - 532 VL - 162 IS - 6 SN - 0002-9262, 0002-9262 KW - Dichlorodiphenyl Dichloroethylene KW - 4M7FS82U08 KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - United States KW - Prospective Studies KW - Humans KW - Adult KW - Follow-Up Studies KW - Time Factors KW - Female KW - Pregnancy KW - Pregnancy Trimester, Third -- blood KW - Polychlorinated Biphenyls -- blood KW - Maternal Exposure KW - Fertility -- physiology KW - Dichlorodiphenyl Dichloroethylene -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68538714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Maternal+serum+levels+of+polychlorinated+biphenyls+and+1%2C1-dichloro-2%2C2-bis%28p-chlorophenyl%29ethylene+%28DDE%29+and+time+to+pregnancy.&rft.au=Law%2C+Dionne+C+Gesink%3BKlebanoff%2C+Mark+A%3BBrock%2C+John+W%3BDunson%2C+David+B%3BLongnecker%2C+Matthew+P&rft.aulast=Law&rft.aufirst=Dionne+C&rft.date=2005-09-15&rft.volume=162&rft.issue=6&rft.spage=523&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-10-20 N1 - Date created - 2005-09-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Synthesis of tripeptides as potent Yersinia protein tyrosine phosphatase inhibitors. AN - 68473349; 16039123 AB - We report the synthesis of a series of monoanionic phosphotyrosyl (pTyr) mimetic-containing tripeptides based on 'Fmoc-Glu(OBn)-Xxx-Leu-amide' (where Xxx = pTyr mimetic) and their N-terminally modified derivatives. The inhibitory potencies of compounds were tested against YopH and human PTP1B enzymes. Several compounds exhibited noteworthy activity against both YopH and PTP1B. Among the N-terminally modified analogues, 5-methylindole derivative 30 was found to be the best moiety to replace base-labile Fmoc group. A mode of binding with YopH is proposed for tripeptides 21, 30, and 31. JF - Bioorganic & medicinal chemistry letters AU - Lee, Kyeong AU - Boovanahalli, Shanthaveerappa K AU - Nam, Ky-Youb AU - Kang, Sang-Uk AU - Lee, Mijeoung AU - Phan, Jason AU - Wu, Li AU - Waugh, David S AU - Zhang, Zhong-Yin AU - No, Kyoung Tai AU - Lee, Jung Jun AU - Burke, Terrence R AD - Laboratory of Medicinal Chemistry, NCI, NIH, NCI-Frederick, Frederick, MD 21702, USA. Y1 - 2005/09/15/ PY - 2005 DA - 2005 Sep 15 SP - 4037 EP - 4042 VL - 15 IS - 18 SN - 0960-894X, 0960-894X KW - Bacterial Outer Membrane Proteins KW - 0 KW - Enzyme Inhibitors KW - Oligopeptides KW - PTPN1 protein, human KW - EC 3.1.3.48 KW - Protein Tyrosine Phosphatase, Non-Receptor Type 1 KW - Protein Tyrosine Phosphatases KW - yopH protein, Yersinia KW - Index Medicus KW - Molecular Structure KW - Models, Molecular KW - Humans KW - Inhibitory Concentration 50 KW - Protein Structure, Tertiary KW - Protein Binding KW - Structure-Activity Relationship KW - Binding Sites KW - Protein Tyrosine Phosphatases -- metabolism KW - Enzyme Inhibitors -- chemistry KW - Oligopeptides -- chemistry KW - Bacterial Outer Membrane Proteins -- metabolism KW - Bacterial Outer Membrane Proteins -- chemistry KW - Oligopeptides -- chemical synthesis KW - Bacterial Outer Membrane Proteins -- antagonists & inhibitors KW - Enzyme Inhibitors -- pharmacology KW - Enzyme Inhibitors -- chemical synthesis KW - Oligopeptides -- pharmacology KW - Yersinia -- enzymology KW - Protein Tyrosine Phosphatases -- chemistry KW - Protein Tyrosine Phosphatases -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68473349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+%26+medicinal+chemistry+letters&rft.atitle=Synthesis+of+tripeptides+as+potent+Yersinia+protein+tyrosine+phosphatase+inhibitors.&rft.au=Lee%2C+Kyeong%3BBoovanahalli%2C+Shanthaveerappa+K%3BNam%2C+Ky-Youb%3BKang%2C+Sang-Uk%3BLee%2C+Mijeoung%3BPhan%2C+Jason%3BWu%2C+Li%3BWaugh%2C+David+S%3BZhang%2C+Zhong-Yin%3BNo%2C+Kyoung+Tai%3BLee%2C+Jung+Jun%3BBurke%2C+Terrence+R&rft.aulast=Lee&rft.aufirst=Kyeong&rft.date=2005-09-15&rft.volume=15&rft.issue=18&rft.spage=4037&rft.isbn=&rft.btitle=&rft.title=Bioorganic+%26+medicinal+chemistry+letters&rft.issn=0960894X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-11-21 N1 - Date created - 2005-08-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Detection of Myocardial Capillary Orientation with Intravascular Nano Iron-Oxide Particles in Spin-echo MRI: R2 Tensor Imaging T2 - 22nd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2005) AN - 40094591; 4000876 JF - 22nd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2005) AU - Vignaud, A C AU - Rodriguez, I AU - Ennis, D B AU - DeSilva, R AU - Kellman, P AU - Taylor, J AU - Bennett, E AU - Wen, H Y1 - 2005/09/15/ PY - 2005 DA - 2005 Sep 15 KW - Particulates KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40094591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=22nd+Annual+Scientific+Meeting+of+the+European+Society+for+Magnetic+Resonance+in+Medicine+and+Biology+%28ESMRMB+2005%29&rft.atitle=Detection+of+Myocardial+Capillary+Orientation+with+Intravascular+Nano+Iron-Oxide+Particles+in+Spin-echo+MRI%3A+R2+Tensor+Imaging&rft.au=Vignaud%2C+A+C%3BRodriguez%2C+I%3BEnnis%2C+D+B%3BDeSilva%2C+R%3BKellman%2C+P%3BTaylor%2C+J%3BBennett%2C+E%3BWen%2C+H&rft.aulast=Vignaud&rft.aufirst=A&rft.date=2005-09-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=22nd+Annual+Scientific+Meeting+of+the+European+Society+for+Magnetic+Resonance+in+Medicine+and+Biology+%28ESMRMB+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.esmrmb.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Carbon-13 Magnetization Transfer Spectroscopy: Detection of Aspartate Aminotransferase reaction in vivo T2 - 22nd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2005) AN - 40094475; 4000846 JF - 22nd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2005) AU - Shen, J Y1 - 2005/09/15/ PY - 2005 DA - 2005 Sep 15 KW - Aspartate aminotransferase KW - Spectroscopy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40094475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=22nd+Annual+Scientific+Meeting+of+the+European+Society+for+Magnetic+Resonance+in+Medicine+and+Biology+%28ESMRMB+2005%29&rft.atitle=Carbon-13+Magnetization+Transfer+Spectroscopy%3A+Detection+of+Aspartate+Aminotransferase+reaction+in+vivo&rft.au=Shen%2C+J&rft.aulast=Shen&rft.aufirst=J&rft.date=2005-09-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=22nd+Annual+Scientific+Meeting+of+the+European+Society+for+Magnetic+Resonance+in+Medicine+and+Biology+%28ESMRMB+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.esmrmb.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regional Strain Mapping of the Carotid Artery Wall in Humans Using DENSE T2 - 22nd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2005) AN - 40059112; 4000845 JF - 22nd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2005) AU - Wen, H AU - Vignaud, A AU - Rodriguez, I Y1 - 2005/09/15/ PY - 2005 DA - 2005 Sep 15 KW - Mapping KW - Carotid artery KW - Strains KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40059112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=22nd+Annual+Scientific+Meeting+of+the+European+Society+for+Magnetic+Resonance+in+Medicine+and+Biology+%28ESMRMB+2005%29&rft.atitle=Regional+Strain+Mapping+of+the+Carotid+Artery+Wall+in+Humans+Using+DENSE&rft.au=Wen%2C+H%3BVignaud%2C+A%3BRodriguez%2C+I&rft.aulast=Wen&rft.aufirst=H&rft.date=2005-09-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=22nd+Annual+Scientific+Meeting+of+the+European+Society+for+Magnetic+Resonance+in+Medicine+and+Biology+%28ESMRMB+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.esmrmb.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Anatomically Guided Shaped Smoothing in Myocardial Strain Data Analysis T2 - 22nd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2005) AN - 40054062; 4000650 JF - 22nd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2005) AU - Wen, H Y1 - 2005/09/15/ PY - 2005 DA - 2005 Sep 15 KW - Data processing KW - Strains KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40054062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=22nd+Annual+Scientific+Meeting+of+the+European+Society+for+Magnetic+Resonance+in+Medicine+and+Biology+%28ESMRMB+2005%29&rft.atitle=Anatomically+Guided+Shaped+Smoothing+in+Myocardial+Strain+Data+Analysis&rft.au=Wen%2C+H&rft.aulast=Wen&rft.aufirst=H&rft.date=2005-09-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=22nd+Annual+Scientific+Meeting+of+the+European+Society+for+Magnetic+Resonance+in+Medicine+and+Biology+%28ESMRMB+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.esmrmb.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TAX, an Element for Increased Receive Array Population Density T2 - 22nd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2005) AN - 40053473; 4000947 JF - 22nd Annual Scientific Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2005) AU - Merkle, H AU - Li, T. AU - Wang, S AU - van Gelderen, P AU - Koretsky, A P AU - Duyn, J H Y1 - 2005/09/15/ PY - 2005 DA - 2005 Sep 15 KW - Population density KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40053473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=22nd+Annual+Scientific+Meeting+of+the+European+Society+for+Magnetic+Resonance+in+Medicine+and+Biology+%28ESMRMB+2005%29&rft.atitle=TAX%2C+an+Element+for+Increased+Receive+Array+Population+Density&rft.au=Merkle%2C+H%3BLi%2C+T.%3BWang%2C+S%3Bvan+Gelderen%2C+P%3BKoretsky%2C+A+P%3BDuyn%2C+J+H&rft.aulast=Merkle&rft.aufirst=H&rft.date=2005-09-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=22nd+Annual+Scientific+Meeting+of+the+European+Society+for+Magnetic+Resonance+in+Medicine+and+Biology+%28ESMRMB+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.esmrmb.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of a Graft-Versus-Host-Like Skin Disease by Intradermal Injection of Ovalbumin-Peptide-Specific CD8+ (OT-I) T Cells into Keratin 14-Ovalbumin-Expressing Transgenic Mice T2 - 9th International Workshop on Langerhans Cells (LC 2005) AN - 39704185; 4016116 JF - 9th International Workshop on Langerhans Cells (LC 2005) AU - Kim, B S AU - Miyagawa, F AU - Katz, S I Y1 - 2005/09/15/ PY - 2005 DA - 2005 Sep 15 KW - Mice KW - Skin diseases KW - Ovalbumin KW - Lymphocytes T KW - Transgenic mice KW - CD8 antigen KW - Keratin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39704185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=9th+International+Workshop+on+Langerhans+Cells+%28LC+2005%29&rft.atitle=Induction+of+a+Graft-Versus-Host-Like+Skin+Disease+by+Intradermal+Injection+of+Ovalbumin-Peptide-Specific+CD8%2B+%28OT-I%29+T+Cells+into+Keratin+14-Ovalbumin-Expressing+Transgenic+Mice&rft.au=Kim%2C+B+S%3BMiyagawa%2C+F%3BKatz%2C+S+I&rft.aulast=Kim&rft.aufirst=B&rft.date=2005-09-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=9th+International+Workshop+on+Langerhans+Cells+%28LC+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.lc2005.at/index.php?open=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oncostatin M Enhances CCL21 Expression by Microvascular Endothelial Cells in Vitro and Increases the Efficiency of Dendritic Cell Trafficking in Vivo T2 - 9th International Workshop on Langerhans Cells (LC 2005) AN - 39704022; 4016078 JF - 9th International Workshop on Langerhans Cells (LC 2005) AU - Cardones, Adela R AU - Sugaya, Makoto AU - Blauvelt, Andrew AU - Hwang, Sam T Y1 - 2005/09/15/ PY - 2005 DA - 2005 Sep 15 KW - Endothelial cells KW - CCL21 protein KW - Microvasculature KW - Oncostatin M KW - Dendritic cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39704022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=9th+International+Workshop+on+Langerhans+Cells+%28LC+2005%29&rft.atitle=Oncostatin+M+Enhances+CCL21+Expression+by+Microvascular+Endothelial+Cells+in+Vitro+and+Increases+the+Efficiency+of+Dendritic+Cell+Trafficking+in+Vivo&rft.au=Cardones%2C+Adela+R%3BSugaya%2C+Makoto%3BBlauvelt%2C+Andrew%3BHwang%2C+Sam+T&rft.aulast=Cardones&rft.aufirst=Adela&rft.date=2005-09-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=9th+International+Workshop+on+Langerhans+Cells+%28LC+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.lc2005.at/index.php?open=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exogenous Administration of IL-15 Breaks Peripheral Tolerance Towards Low Dose Antigen in Experimental Graft VS. Host Disease T2 - 9th International Workshop on Langerhans Cells (LC 2005) AN - 39643924; 4016141 JF - 9th International Workshop on Langerhans Cells (LC 2005) AU - Miyagawa, Fumi AU - Kim, B S AU - Patel, H AU - Tagaya, Y AU - Waldmann, T A AU - Katz, Stephen I Y1 - 2005/09/15/ PY - 2005 DA - 2005 Sep 15 KW - Hosts KW - Immunological tolerance KW - Interleukin 15 KW - Antigens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39643924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=9th+International+Workshop+on+Langerhans+Cells+%28LC+2005%29&rft.atitle=Exogenous+Administration+of+IL-15+Breaks+Peripheral+Tolerance+Towards+Low+Dose+Antigen+in+Experimental+Graft+VS.+Host+Disease&rft.au=Miyagawa%2C+Fumi%3BKim%2C+B+S%3BPatel%2C+H%3BTagaya%2C+Y%3BWaldmann%2C+T+A%3BKatz%2C+Stephen+I&rft.aulast=Miyagawa&rft.aufirst=Fumi&rft.date=2005-09-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=9th+International+Workshop+on+Langerhans+Cells+%28LC+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.lc2005.at/index.php?open=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER -