TY - JOUR T1 - Human P2Y sub(6) Receptor: Molecular Modeling Leads to the Rational Design of a Novel Agonist Based on a Unique Conformational Preference AN - 19387457; 7158854 AB - Combining molecular dynamics (MD) in a hydrated phospholipid (DOPC) bilayer, a Monte Carlo search, and synthesis of locked nucleotide analogues, we discovered that the Southern conformation of the ribose is preferred for ligand recognition by the P2Y sub(6) receptor. 2'-Deoxy-(S)-methanocarbaUDP was found to be a full agonist of the receptor and displayed a 10-fold higher potency than that for the corresponding flexible 2'-deoxyUDP. MD results also suggested a conformational change of the second extracellular loop consequent to agonist binding. JF - Journal of Medicinal Chemistry AU - Costanzi, S AU - Joshi, B V AU - Maddileti, S AU - Mamedova, L AU - Gonzalez-Moa, MJ AU - Marquez, V E AU - Harden, T K AU - Jacobson, KA AD - Computational Chemistry Core Laboratory and Molecular Recognition Section, NIDDK, National Institutes of Health, DHHS, Bethesda, Maryland 20892, USA Y1 - 2005/12/29/ PY - 2005 DA - 2005 Dec 29 SP - 8108 EP - 8111 VL - 48 IS - 26 SN - 0022-2623, 0022-2623 KW - Biotechnology and Bioengineering Abstracts KW - Molecular modelling KW - Ribose KW - Purine P2Y receptors KW - Nucleotide analogs KW - Phospholipids KW - Conformation KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19387457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medicinal+Chemistry&rft.atitle=Human+P2Y+sub%286%29+Receptor%3A+Molecular+Modeling+Leads+to+the+Rational+Design+of+a+Novel+Agonist+Based+on+a+Unique+Conformational+Preference&rft.au=Costanzi%2C+S%3BJoshi%2C+B+V%3BMaddileti%2C+S%3BMamedova%2C+L%3BGonzalez-Moa%2C+MJ%3BMarquez%2C+V+E%3BHarden%2C+T+K%3BJacobson%2C+KA&rft.aulast=Costanzi&rft.aufirst=S&rft.date=2005-12-29&rft.volume=48&rft.issue=26&rft.spage=8108&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medicinal+Chemistry&rft.issn=00222623&rft_id=info:doi/10.1021%2Fjm050911p LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Nucleotide analogs; Purine P2Y receptors; Conformation; Ribose; Phospholipids; Molecular modelling DO - http://dx.doi.org/10.1021/jm050911p ER - TY - JOUR T1 - Semirational Design of (North)-Methanocarba Nucleosides as Dual Acting A sub(1) and A sub(3) Adenosine Receptor Agonists: Novel Prototypes for Cardioprotection AN - 19386734; 7158853 AB - Ring-constrained adenosine analogues have been designed to act as dual agonists at tissue-protective A sub(1) and A sub(3) adenosine receptors (ARs). 9-Ribosides transformed into the ring-constrained (N)-methanocarba-2-chloro-5'-uronamides consistently lost affinity at A sub(1)/A sub(2A)ARs and gained at A sub(3)AR. Among 9-riboside derivatives, only N super(6)-cyclopentyl and 7-norbornyl moieties were extrapolated for mixed A sub(1)/A sub(3) selectivity and rat/human A sub(3)AR equipotency. Consequently, 2 was balanced in affinity and potency at A sub(1)/A sub(3)ARs as envisioned and dramatically protected in an intact heart model of global ischemia and reperfusion. JF - Journal of Medicinal Chemistry AU - Jacobson, KA AU - Gao, Z-G AU - Tchilibon, S AU - Duong, H T AU - Joshi, B V AU - Sonin, D AU - Liang, B T AD - Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2005/12/29/ PY - 2005 DA - 2005 Dec 29 SP - 8103 EP - 8107 VL - 48 IS - 26 SN - 0022-2623, 0022-2623 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Reperfusion KW - Adenosine receptors KW - nucleosides KW - Ischemia KW - Models KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19386734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medicinal+Chemistry&rft.atitle=Semirational+Design+of+%28North%29-Methanocarba+Nucleosides+as+Dual+Acting+A+sub%281%29+and+A+sub%283%29+Adenosine+Receptor+Agonists%3A+Novel+Prototypes+for+Cardioprotection&rft.au=Jacobson%2C+KA%3BGao%2C+Z-G%3BTchilibon%2C+S%3BDuong%2C+H+T%3BJoshi%2C+B+V%3BSonin%2C+D%3BLiang%2C+B+T&rft.aulast=Jacobson&rft.aufirst=KA&rft.date=2005-12-29&rft.volume=48&rft.issue=26&rft.spage=8103&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medicinal+Chemistry&rft.issn=00222623&rft_id=info:doi/10.1021%2Fjm050726b LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Adenosine receptors; Ischemia; Reperfusion; Heart; nucleosides; Models DO - http://dx.doi.org/10.1021/jm050726b ER - TY - JOUR T1 - Antifungal Flavonoids from Hildegardia barteri AN - 19829804; 6674756 AB - A new isoflavan, (3R)-6,2'-dihydroxy-7-methoxy-4',5'-methylenedioxyisoflavan, hildegardiol (1), and two known flavonoids, 2-hydroxymaackiain (2) and farrerol (3), were isolated from the antifungal root extract of Hildegardia barteri. The pterocarpan 2 was largely responsible for the observed antifungal activity. JF - Journal of Natural Products AU - Meragelman, T L AU - Tucker, K D AU - McCloud, T G AU - Cardellina, JH II AU - Shoemaker, R H AD - Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, and SAIC-Frederick, Inc., National Cancer Institute-Frederick, Frederick, Maryland 21702-1201, USA Y1 - 2005/12/26/ PY - 2005 DA - 2005 Dec 26 SP - 1790 EP - 1792 VL - 68 IS - 12 SN - 0163-3864, 0163-3864 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Flavonoids KW - Antifungal activity KW - Roots KW - natural products KW - K 03340:Effects of Physical & Chemical Factors KW - A 01067:Antifungal & fungicidal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19829804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Natural+Products&rft.atitle=Antifungal+Flavonoids+from+Hildegardia+barteri&rft.au=Meragelman%2C+T+L%3BTucker%2C+K+D%3BMcCloud%2C+T+G%3BCardellina%2C+JH+II%3BShoemaker%2C+R+H&rft.aulast=Meragelman&rft.aufirst=T&rft.date=2005-12-26&rft.volume=68&rft.issue=12&rft.spage=1790&rft.isbn=&rft.btitle=&rft.title=Journal+of+Natural+Products&rft.issn=01633864&rft_id=info:doi/10.1021%2Fnp0503000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Flavonoids; Antifungal activity; Roots; natural products DO - http://dx.doi.org/10.1021/np0503000 ER - TY - JOUR T1 - Hormonal contraceptive use, pregnancy and parity, and the risk of cervical intraepithelial neoplasia 3 among oncogenic HPV DNA-positive women with equivocal or mildly abnormal cytology. AN - 68731855; 15986443 AB - Oral contraceptive (OC) use, hormonal contraceptive use and multiparity are potential risk factors for cervical precancer, cervical intraepithelial neoplasia 3 (CIN3), but a limited number of studies have adequately accounted for possible confounding effect of oncogenic human papillomavirus (HPV) infection. To examine the relationships of these factors with CIN3, we conducted an analysis of women (n = 5,060) with minimally abnormal Pap smears who were enrolled in the ASCUS and LSIL Triage Study (ALTS), a clinical trial to evaluate management strategies. Cervical specimens collected at enrollment were tested for HPV DNA using 2 methods. Multivariate logistics regression models were used to assess associations (odds ratio [OR] with 95% confidence intervals [CI]) of the potential risk factors (e.g., OC use and parity) with testing oncogenic HPV positive among controls ( or =7). Total, red, or white meat intake was not associated with prostate cancer risk. More than 10 g/d of very well done meat, compared with no consumption, was associated with a 1.4-fold increased risk of prostate cancer [95% confidence interval (95% CI), 1.05-1.92] and a 1.7-fold increased risk (95% CI, 1.19-2.40) of incident disease. Although there was no association with MeIQx and DiMeIQx, the highest quintile of PhIP was associated with a 1.2-fold increased risk of prostate cancer (95% CI, 1.01-1.48) and a 1.3-fold increased risk of incident disease (95% CI, 1.01-1.61). In conclusion, very well done meat was positively associated with prostate cancer risk. In addition, this study lends epidemiologic support to the animal studies, which have implicated PhIP as a prostate carcinogen. JF - Cancer research AU - Cross, Amanda J AU - Peters, Ulrike AU - Kirsh, Victoria A AU - Andriole, Gerald L AU - Reding, Douglas AU - Hayes, Richard B AU - Sinha, Rashmi AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA. crossa@mail.nih.gov Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 SP - 11779 EP - 11784 VL - 65 IS - 24 SN - 0008-5472, 0008-5472 KW - Imidazoles KW - 0 KW - Mutagens KW - Quinoxalines KW - Benzo(a)pyrene KW - 3417WMA06D KW - 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline KW - 77500-04-0 KW - 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine KW - 909C6UN66T KW - 3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine KW - YRA7G7WU6P KW - Index Medicus KW - Quinoxalines -- chemistry KW - Quinoxalines -- adverse effects KW - Prospective Studies KW - Risk Factors KW - Humans KW - Surveys and Questionnaires KW - Benzo(a)pyrene -- chemistry KW - Aged KW - Middle Aged KW - Benzo(a)pyrene -- adverse effects KW - Male KW - Imidazoles -- adverse effects KW - Imidazoles -- chemistry KW - Prostatic Neoplasms -- etiology KW - Meat KW - Prostatic Neoplasms -- epidemiology KW - Mutagens -- adverse effects KW - Cooking KW - Diet KW - Mutagens -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68900059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=A+prospective+study+of+meat+and+meat+mutagens+and+prostate+cancer+risk.&rft.au=Cross%2C+Amanda+J%3BPeters%2C+Ulrike%3BKirsh%2C+Victoria+A%3BAndriole%2C+Gerald+L%3BReding%2C+Douglas%3BHayes%2C+Richard+B%3BSinha%2C+Rashmi&rft.aulast=Cross&rft.aufirst=Amanda&rft.date=2005-12-15&rft.volume=65&rft.issue=24&rft.spage=11779&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-23 N1 - Date created - 2005-12-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Upregulation of estrogen receptor expression in the uterus of ovariectomized B6C3F1 mice and Ishikawa cells treated with bromoethane. AN - 68865104; 15922381 AB - In a 2-year NTP bioassay, Bromoethane (BE) was found to induce endometrial neoplasms in the uterus of B6C3F1 mice [; ]. In women, hormonal influences, such as "unopposed" estrogenic stimulus, have been implicated as important etiologic factors in uterine cancer. BE, however, does not affect the serum concentrations of sex hormones in female B6C3F1 mice [] and the mechanism of BE-induced uterine carcinogenesis still remains unclear. In the present study, we examined the estrogenic effects of BE on the uterus of ovariectomized B6C3F1 mice and on Ishikawa cells. Groups of 6 mice were given daily s.c. injections of 0, 100, 500 or 1000 mg BE/kg for 3 consecutive days. Mice treated with 17beta-estradiol served as positive controls. Mice were necropsied 24 h after the final injection, and uteri were weighed and examined histologically and immunohistochemically along with the vagina. Changes observed in the estrogen-treated mice included increased uterine weights, edema and inflammation of the endometrium, increased epithelial layers of the uterine and vaginal lumens and keratinization of the vaginal epithelium. In the BE-treated mice, no such changes occurred; however, immunohistochemical staining of the uterus revealed a significant increase in immunoexpression of the estrogen receptor alpha (ERalpha) in the two higher dose groups. Analysis of mRNA also showed slightly increased uterine ERalpha expression in these groups. Upregulated expression of ERalpha was confirmed in BE-treated Ishikawa cells, in which Western blotting analyses identified an intense signal at approximately 66 kDa, which is consistent with ERalpha. These data suggest that upregulated expression of ERalpha may be important in the induction of endometrial neoplasms in BE-treated mice. JF - Toxicology and applied pharmacology AU - Aoyama, Hiroaki AU - Couse, John F AU - Hewitt, Sylvia C AU - Haseman, Joseph K AU - He, Hong AU - Zheng, Xiaolin AU - Majstoravich, Sonja AU - Korach, Kenneth S AU - Dixon, D AD - Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, P.O. Box 12233, MD C2-09, Research Triangle Park, NC 27709, USA. Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 SP - 226 EP - 235 VL - 209 IS - 3 SN - 0041-008X, 0041-008X KW - Estrogen Receptor alpha KW - 0 KW - Hydrocarbons, Brominated KW - Proliferating Cell Nuclear Antigen KW - Estradiol KW - 4TI98Z838E KW - Hypoxanthine Phosphoribosyltransferase KW - EC 2.4.2.8 KW - Ribonucleases KW - EC 3.1.- KW - bromoethane KW - LI8384T9PH KW - Index Medicus KW - Animals KW - Endometritis -- chemically induced KW - Ribonucleases -- antagonists & inhibitors KW - Dose-Response Relationship, Drug KW - Estradiol -- pharmacology KW - Hypoxanthine Phosphoribosyltransferase -- metabolism KW - Proliferating Cell Nuclear Antigen -- analysis KW - Mice KW - Cell Line, Tumor KW - Ribonucleases -- metabolism KW - Mice, Inbred Strains KW - Blotting, Western KW - Endometrium -- drug effects KW - Up-Regulation -- drug effects KW - Endometrium -- chemistry KW - Injections, Subcutaneous KW - Endometrium -- pathology KW - Immunochemistry -- methods KW - Endometritis -- pathology KW - Female KW - Organ Size -- drug effects KW - Uterus -- metabolism KW - Estrogen Receptor alpha -- biosynthesis KW - Hydrocarbons, Brominated -- administration & dosage KW - Ovariectomy KW - Uterus -- drug effects KW - Hydrocarbons, Brominated -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68865104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Upregulation+of+estrogen+receptor+expression+in+the+uterus+of+ovariectomized+B6C3F1+mice+and+Ishikawa+cells+treated+with+bromoethane.&rft.au=Aoyama%2C+Hiroaki%3BCouse%2C+John+F%3BHewitt%2C+Sylvia+C%3BHaseman%2C+Joseph+K%3BHe%2C+Hong%3BZheng%2C+Xiaolin%3BMajstoravich%2C+Sonja%3BKorach%2C+Kenneth+S%3BDixon%2C+D&rft.aulast=Aoyama&rft.aufirst=Hiroaki&rft.date=2005-12-15&rft.volume=209&rft.issue=3&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-17 N1 - Date created - 2005-12-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prednisolone pharmacokinetics in the presence and absence of ritonavir after oral prednisone administration to healthy volunteers. AN - 68796678; 16284534 AB - Corticosteroid therapy has been associated with bone toxicities (eg, osteonecrosis) and Cushing syndrome in HIV-infected patients; this may be partially attributable to a pharmacokinetic drug interaction between HIV protease inhibitors and corticosteroids. The purpose of this study was to characterize the influence of low-dose ritonavir on prednisolone pharmacokinetics in healthy subjects. Ten HIV-seronegative volunteers were given single oral doses of prednisone, 20 mg, before (baseline) and after receiving ritonavir, 200 mg, twice daily for 4 and 14 days. After each prednisone dose, serial blood samples were collected and prednisolone concentrations were determined; pharmacokinetic parameter values were compared between the groups. Geometric mean ratios (GMRs, 90% confidence interval [CI]) of the prednisolone area under the plasma concentration versus time curve (AUC0-infinity) after 4 and 14 days of ritonavir versus baseline were 1.41 (90% CI: 1.08 to 1.74) and 1.30 (90% CI: 1.09 to 1.49), respectively (P = 0.002 and P = 0.004, respectively). GMRs of prednisolone apparent oral clearance (Cl/F) were 0.71 (09% CI: 0.57 to 0.93) and 0.77 (90% CI: 0.67 to 0.92) after 4 and 14 days of ritonavir versus baseline, respectively (P = 0.0004 and P = 0.0003, respectively). Ritonavir significantly increased the systemic exposure of prednisolone in healthy subjects. Results from this investigation suggest that corticosteroid exposure is likely elevated in HIV-infected patients receiving protease inhibitors. JF - Journal of acquired immune deficiency syndromes (1999) AU - Penzak, Scott R AU - Formentini, Elizabeth AU - Alfaro, Raul M AU - Long, Michael AU - Natarajan, Ven AU - Kovacs, Joseph AD - Warren G. Magnuson Clinical Center, Pharmacy Department, National Institutes of Health, Bethesda, MD 20892, USA. Spenzak@mail.cc.nih.gov Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 SP - 573 EP - 580 VL - 40 IS - 5 SN - 1525-4135, 1525-4135 KW - Glucocorticoids KW - 0 KW - HIV Protease Inhibitors KW - Prednisolone KW - 9PHQ9Y1OLM KW - Ritonavir KW - O3J8G9O825 KW - Index Medicus KW - AIDS/HIV KW - Drug Interactions KW - Area Under Curve KW - Humans KW - Adult KW - HIV Seronegativity KW - Male KW - Female KW - Prednisolone -- pharmacokinetics KW - Glucocorticoids -- pharmacokinetics KW - Ritonavir -- pharmacokinetics KW - Ritonavir -- pharmacology KW - Glucocorticoids -- administration & dosage KW - Ritonavir -- administration & dosage KW - HIV Protease Inhibitors -- pharmacology KW - HIV Protease Inhibitors -- pharmacokinetics KW - Prednisolone -- administration & dosage KW - HIV Protease Inhibitors -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68796678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.atitle=Prednisolone+pharmacokinetics+in+the+presence+and+absence+of+ritonavir+after+oral+prednisone+administration+to+healthy+volunteers.&rft.au=Penzak%2C+Scott+R%3BFormentini%2C+Elizabeth%3BAlfaro%2C+Raul+M%3BLong%2C+Michael%3BNatarajan%2C+Ven%3BKovacs%2C+Joseph&rft.aulast=Penzak&rft.aufirst=Scott&rft.date=2005-12-15&rft.volume=40&rft.issue=5&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.issn=15254135&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-23 N1 - Date created - 2005-11-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Uptake and Trafficking of Exogenous Sterol in Saccharomyces Cerevisiae T2 - 2005 Biochemical Society Focused Meeting on Non-Vesicular Intracellular Traffic AN - 39824813; 4040165 JF - 2005 Biochemical Society Focused Meeting on Non-Vesicular Intracellular Traffic AU - Prinz, Will Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Sterols KW - Saccharomyces cerevisiae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39824813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+consulting+and+clinical+psychology&rft.atitle=A+new+tool+to+assess+treatment+fidelity+and+evaluation+of+treatment+fidelity+across+10+years+of+health+behavior+research&rft.au=Borrelli%2C+Belinda%3BSepinwall%2C+Deborah%3BErnst%2C+Denise%3BBellg%2C+Albert+J%3BCzajkowski%2C+Susan%3BBreger%2C+Rosemary%3BDeFrancesco%2C+Carol%3BLevesque%2C+Chantal%3BSharp%2C+Daryl+L%3BOgedegbe%2C+Gbenga%3BResnick%2C+Barbara%3BOrwig%2C+Denise&rft.aulast=Borrelli&rft.aufirst=Belinda&rft.date=2005-10-01&rft.volume=73&rft.issue=5&rft.spage=852&rft.isbn=&rft.btitle=&rft.title=Journal+of+consulting+and+clinical+psychology&rft.issn=0022006X&rft_id=info:doi/10.1037%2F0022-006X.73.5.852 L2 - http://www.biochemistry.org/meetings/programme.cfm?Meeting_No=SA053 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Amazing Versatility of Proteins - Structural Polymorphism and Evolution T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39823201; 4060133 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Gronenborn, A M AU - Byeon, I L AU - Louis, J M Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Gene polymorphism KW - Evolution KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39823201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=The+Amazing+Versatility+of+Proteins+-+Structural+Polymorphism+and+Evolution&rft.au=Gronenborn%2C+A+M%3BByeon%2C+I+L%3BLouis%2C+J+M&rft.aulast=Gronenborn&rft.aufirst=A&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Direct Effects of Ionizing Radiation on Supercoiled Plasmid DNA T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39808881; 4060927 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Kempner, E S AU - Anchordoquy, T AU - Molina, M Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Ionizing radiation KW - Plasmids KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39808881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Direct+Effects+of+Ionizing+Radiation+on+Supercoiled+Plasmid+DNA&rft.au=Kempner%2C+E+S%3BAnchordoquy%2C+T%3BMolina%2C+M&rft.aulast=Kempner&rft.aufirst=E&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Solution Structure of the Phosphoryl Transfer Complex Between the Cytoplasmic A Domain and B Domain of the Mannitol Transporter II: Mannitol of the E. Coli Phosphotransferase System T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39808578; 4058040 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Suh, J AU - Cai, M AU - Williams Jr, D AU - Clore, M Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Mannitol KW - Phosphotransferase KW - Escherichia coli KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39808578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Solution+Structure+of+the+Phosphoryl+Transfer+Complex+Between+the+Cytoplasmic+A+Domain+and+B+Domain+of+the+Mannitol+Transporter+II%3A+Mannitol+of+the+E.+Coli+Phosphotransferase+System&rft.au=Suh%2C+J%3BCai%2C+M%3BWilliams+Jr%2C+D%3BClore%2C+M&rft.aulast=Suh&rft.aufirst=J&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Continued Importance of Medicinal Plants and International Collaboration in the Discovery of Novel Drug Leads T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39806338; 4064226 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Cragg, G M Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Medicinal plants KW - Drug discovery KW - Lead KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39806338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Continued+Importance+of+Medicinal+Plants+and+International+Collaboration+in+the+Discovery+of+Novel+Drug+Leads&rft.au=Cragg%2C+G+M&rft.aulast=Cragg&rft.aufirst=G&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Visualizing Structural Dynamics in Proteins withPicosecond Time-Resolved Laue Crystallography T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39784870; 4064466 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Anfinrud, P AU - Schotte, F AU - Hummer, G AU - Wulff, M Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Crystallography KW - Structural dynamics KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39784870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Visualizing+Structural+Dynamics+in+Proteins+withPicosecond+Time-Resolved+Laue+Crystallography&rft.au=Anfinrud%2C+P%3BSchotte%2C+F%3BHummer%2C+G%3BWulff%2C+M&rft.aulast=Anfinrud&rft.aufirst=P&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chromatographic Chiral Recognition on Immobilized Cellular Membrane-based Stationary Phase: The Enantioselective Binding of Noncompetitive Inhibitors to Neuronal Nicotinic Acetylcholine Receptors T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39780037; 4059238 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Wainer, I W Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Acetylcholine receptors (nicotinic) KW - Stationary phase KW - Neurotransmitters KW - Inhibitors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39780037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Chromatographic+Chiral+Recognition+on+Immobilized+Cellular+Membrane-based+Stationary+Phase%3A+The+Enantioselective+Binding+of+Noncompetitive+Inhibitors+to+Neuronal+Nicotinic+Acetylcholine+Receptors&rft.au=Tarran%2C+Robert%3BButton%2C+Brian%3BPicher%2C+Maryse%3BParadiso%2C+Anthony+M%3BRibeiro%2C+Carla+M%3BLazarowski%2C+Eduardo+R%3BZhang%2C+Liqun%3BCollins%2C+Peter+L%3BPickles%2C+Raymond+J%3BFredberg%2C+Jeffrey+J%3BBoucher%2C+Richard+C&rft.aulast=Tarran&rft.aufirst=Robert&rft.date=2005-10-01&rft.volume=280&rft.issue=42&rft.spage=35751&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NIH Dietary Supplements Methods and Reference Materials Program T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39777812; 4058646 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Betz, J M Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Dietary supplements KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39777812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=NIH+Dietary+Supplements+Methods+and+Reference+Materials+Program&rft.au=Betz%2C+J+M&rft.aulast=Betz&rft.aufirst=J&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recent Developments with Anti-HIV Cyclotides and Other Naturally Occurring Cyclized Peptides" T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39775900; 4060136 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Gustafson, K Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Peptides KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39775900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Recent+Developments+with+Anti-HIV+Cyclotides+and+Other+Naturally+Occurring+Cyclized+Peptides%22&rft.au=Gustafson%2C+K&rft.aulast=Gustafson&rft.aufirst=K&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of an Open Tubular Column Containing Immobilized P-glycoprotein with Caco-2 Cell Monolayers for the Identification of Pgp Substrates T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39773250; 4059052 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Wainer, I W AU - Moaddel, R AU - Bullock, P Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - P-Glycoprotein KW - Monomolecular films KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39773250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Comparison+of+an+Open+Tubular+Column+Containing+Immobilized+P-glycoprotein+with+Caco-2+Cell+Monolayers+for+the+Identification+of+Pgp+Substrates&rft.au=Wainer%2C+I+W%3BMoaddel%2C+R%3BBullock%2C+P&rft.aulast=Wainer&rft.aufirst=I&rft.date=2005-12-15&rft.volume=187&rft.issue=20&rft.spage=7081&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV-1 Integrase Inhibitor Development Based on Model of Full-Length HIV-1 Integrase Complexed with Viral DNA T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39772741; 4059646 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Nicklaus, M C AU - Karki, R G Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Integrase KW - Models KW - Inhibitors KW - Human immunodeficiency virus 1 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39772741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=HIV-1+Integrase+Inhibitor+Development+Based+on+Model+of+Full-Length+HIV-1+Integrase+Complexed+with+Viral+DNA&rft.au=Nicklaus%2C+M+C%3BKarki%2C+R+G&rft.aulast=Nicklaus&rft.aufirst=M&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Molecular Target Modulating Metabolites from Marine Sponges and Bryozoans T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39769995; 4063612 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Gustafson, K AU - Oku, N AU - Milanowski, D AU - McMahon, J Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Porifera KW - Metabolites KW - Marine invertebrates KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39769995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=New+Molecular+Target+Modulating+Metabolites+from+Marine+Sponges+and+Bryozoans&rft.au=Gustafson%2C+K%3BOku%2C+N%3BMilanowski%2C+D%3BMcMahon%2C+J&rft.aulast=Gustafson&rft.aufirst=K&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chemotherapeutic Potentiation of Targeted a-Particle Therapy T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39764645; 4067400 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Brechbiel, M AU - Milenic, D AU - Garmestani, K AU - Abdulla, A AU - Overstreet, T Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Potentiation KW - Therapy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39764645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Chemotherapeutic+Potentiation+of+Targeted+a-Particle+Therapy&rft.au=Brechbiel%2C+M%3BMilenic%2C+D%3BGarmestani%2C+K%3BAbdulla%2C+A%3BOverstreet%2C+T&rft.aulast=Brechbiel&rft.aufirst=M&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Value of Natural Products as Leads to Drug Candidates T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39762796; 4058002 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Newman, D J Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Drugs KW - Natural products KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39762796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Value+of+Natural+Products+as+Leads+to+Drug+Candidates&rft.au=Newman%2C+D+J&rft.aulast=Newman&rft.aufirst=D&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structure, Dynamics and Function of Water in Hydrophobic Confinement T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39757041; 4065375 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Hummer, G Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Structure-function relationships KW - Hydrophobicity KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39757041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Structure%2C+Dynamics+and+Function+of+Water+in+Hydrophobic+Confinement&rft.au=Hummer%2C+G&rft.aulast=Hummer&rft.aufirst=G&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Marine Natural Products in Current Screening Approaches at the National Cancer Institute T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39754226; 4063037 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Cardellina, J H AU - Scudiero, D A AU - McCloud, T G AU - Shoemaker, R H Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Cancer KW - Natural products KW - Screening KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39754226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Marine+Natural+Products+in+Current+Screening+Approaches+at+the+National+Cancer+Institute&rft.au=Cardellina%2C+J+H%3BScudiero%2C+D+A%3BMcCloud%2C+T+G%3BShoemaker%2C+R+H&rft.aulast=Cardellina&rft.aufirst=J&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Examining Reaction Processes in Macromolecular Systems T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39746039; 4065634 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Woodcock, H L AU - Hodoscek, M AU - Brooks, B R Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Macromolecules KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39746039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Examining+Reaction+Processes+in+Macromolecular+Systems&rft.au=Woodcock%2C+H+L%3BHodoscek%2C+M%3BBrooks%2C+B+R&rft.aulast=Woodcock&rft.aufirst=H&rft.date=2005-12-15&rft.volume=&rft.issue=19&rft.spage=6862&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fish are Contaminated with Mercury and PCBs: Collaborating with the Hmong Community in Milwaukee to Communicate the Risks and Benefits of Local Fish Consumption T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39721561; 4058648 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Petering, D H AU - Kiatousaysy, L AU - McAvoy, P AU - Rostenkowski, A AU - Weber, D AU - Gallun, T AU - Dellinger, J AU - Driscoll, M AU - Percy, S Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - USA, Wisconsin, Milwaukee KW - Pisces KW - Heavy metals KW - Mercury KW - PCB KW - Polychlorinated biphenyls KW - Fish consumption KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39721561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Fish+are+Contaminated+with+Mercury+and+PCBs%3A+Collaborating+with+the+Hmong+Community+in+Milwaukee+to+Communicate+the+Risks+and+Benefits+of+Local+Fish+Consumption&rft.au=Petering%2C+D+H%3BKiatousaysy%2C+L%3BMcAvoy%2C+P%3BRostenkowski%2C+A%3BWeber%2C+D%3BGallun%2C+T%3BDellinger%2C+J%3BDriscoll%2C+M%3BPercy%2C+S&rft.aulast=Petering&rft.aufirst=D&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Weak Alignment Offers New Opportunities in NMR Structure Determination T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39720494; 4059971 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Bax, A AU - Grishaev, A AU - Bryce, D AU - Jaroniec, C AU - Wu, J. AU - Baber, J AU - Ulmer, T AU - Delaglio, F Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - N.M.R. KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39720494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Weak+Alignment+Offers+New+Opportunities+in+NMR+Structure+Determination&rft.au=Bax%2C+A%3BGrishaev%2C+A%3BBryce%2C+D%3BJaroniec%2C+C%3BWu%2C+J.%3BBaber%2C+J%3BUlmer%2C+T%3BDelaglio%2C+F&rft.aulast=Bax&rft.aufirst=A&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role and Value of Natural Products T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39719901; 4057895 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Newman, D J Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Natural products KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39719901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Role+of+RcsF+in+Signaling+to+the+Rcs+Phosphorelay+Pathway+in+Escherichia+coli&rft.au=Majdalani%2C+Nadim%3BHeck%2C+Michael%3BStout%2C+Valerie%3BGottesman%2C+Susan&rft.aulast=Majdalani&rft.aufirst=Nadim&rft.date=2005-10-01&rft.volume=187&rft.issue=19&rft.spage=6770&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanism of Sonodynamic Therapy of Cancer Cells T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39711926; 4059452 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Miyoshi, N AU - Sostaric, J Z AU - Tuziuti, T AU - Kyuichi, Y AU - Iida, Y AU - Peter, R Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Cancer KW - Therapy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39711926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Mechanism+of+Sonodynamic+Therapy+of+Cancer+Cells&rft.au=Miyoshi%2C+N%3BSostaric%2C+J+Z%3BTuziuti%2C+T%3BKyuichi%2C+Y%3BIida%2C+Y%3BPeter%2C+R&rft.aulast=Miyoshi&rft.aufirst=N&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Marine Natural Products: Inhibitors in Infectious Diseases T2 - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AN - 39708302; 4063044 JF - 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2005) AU - Bewley, C Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 KW - Infectious diseases KW - Natural products KW - Inhibitors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39708302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.atitle=Marine+Natural+Products%3A+Inhibitors+in+Infectious+Diseases&rft.au=Bewley%2C+C&rft.aulast=Bewley&rft.aufirst=C&rft.date=2005-12-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+International+Chemical+Congress+of+Pacific+Basin+Societies+%28PACIFICHEM+2005%29&rft.issn=&rft_id=info:doi/ L2 - http://www.pacifichem.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Progress and New Directions in Genetics of Tuberculosis: An NHLBI Working Group Report AN - 199606419; 16192449 AB - Tuberculosis (TB), along with AIDS and malaria, is one of the three major killers among infectious diseases. New approaches to preventing, diagnosing, and curing TB are needed, which depend on a better understanding of Mycobacterium tuberculosis and the host. The National Heart, Lung, and Blood Institute convened a working group to develop recommendations for future TB research, including genetic aspects of the disease. The following areas were identified: (1) animal model research to improve understanding of persistence, reactivation, and granulomatous reactions; (2) preclinical studies aimed at shortening treatment of TB; (3) new resources for manipulating and characterizing the M. tuberculosis genome, proteome chips for more specific diagnoses, and studies of genes that appear to be essential but whose functions are not known; (4) prospective studies associated with clinical trials in populations with or at risk of TB to advance development of diagnostics and prognostics; (5) new quantitative and bioinformatic approaches to study the interaction between M. tuberculosis and the infected host and how this influences the infection process; (6) molecular characterization of M. tuberculosis genome diversity and phylogenetic analysis; (7) coordinated studies of human genome scans; (8) genetic epidemiology studies; (9) activities to foster knowledge dissemination, education, and training; and (10) coordination between the National Institutes of Health, the Gates Foundation, the Global Alliance for Tuberculosis Drug Development, and other organizations. JF - American Journal of Respiratory and Critical Care Medicine AU - Smith, Issar AU - Nathan, Carl AU - Peavy, Hannah H Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 SP - 1491 EP - 6 CY - New York PB - American Thoracic Society VL - 172 IS - 12 SN - 1073449X KW - Medical Sciences--Respiratory Diseases KW - Animals KW - Tuberculosis -- therapy KW - Humans KW - Tuberculosis -- physiopathology KW - Biomedical Research -- trends KW - Tuberculosis -- genetics KW - Mycobacterium tuberculosis -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/199606419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Progress+and+New+Directions+in+Genetics+of+Tuberculosis%3A+An+NHLBI+Working+Group+Report&rft.au=Smith%2C+Issar%3BNathan%2C+Carl%3BPeavy%2C+Hannah+H&rft.aulast=Smith&rft.aufirst=Issar&rft.date=2005-12-15&rft.volume=172&rft.issue=12&rft.spage=1491&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Thoracic Society Dec 15, 2005 N1 - Last updated - 2017-01-07 ER - TY - JOUR T1 - Biological, cellular, and molecular characteristics of an inducible transgenic skin tumor model: a review AN - 19742040; 6687887 AB - The genetically initiated Tg.AC transgenic mouse carries a transgene consisting of an oncogenic v-Ha-ras coding region flanked 5' by a mouse xi -globin promoter and 3' by an SV-40 polyadenylation sequence. Located on chromosome 11, the transgene is transcriptionally silent until activated by chemical carcinogens, UV light, or full-thickness wounding. Expression of the transgene is an early event that drives cellular proliferation resulting in clonal expansion and tumor formation, the unique characteristics now associated with the Tg.AC mouse. This ras-dependent phenotype has resulted in the widespread interest and use of the Tg.AC mouse in experimental skin carcinogenesis and as an alternative carcinogenesis assay. This review examines the general biology of the tumorigenic responses observed in Tg.AC mice, the genetic interactions of the ras transgene, and explores the cellular and molecular regulation of xi -globin promoted transgene expression. As a prototype alternative model to the current long-term rodent bioassays, the Tg.AC has generated a healthy discussion on the future of transgenic bioassays, and opened the doors for subsequent models for toxicity testing. The further exploration and elucidation of the molecular controls of transgene expression will enhance the usefulness of this mouse and enable a better understanding of the Tg. AC's discriminate response to chemical carcinogens. JF - Oncogene AU - Humble, M C AU - Trempus, C S AU - Spalding, J W AU - Cannon, R E AU - Tennant, R W AD - National Center for Toxicogenomics, National Institute of Environmental Health Sciences, PO Box 12233, MD F1-05, 111 Alexander Drive, Research Triangle Park, NC 27709, USA Y1 - 2005/12/15/ PY - 2005 DA - 2005 Dec 15 SP - 8217 EP - 8228 VL - 24 IS - 56 SN - 0950-9232, 0950-9232 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Oncogenes & Growth Factors Abstracts KW - Ras protein KW - chromosome 11 KW - Molecular modelling KW - Skin KW - Animal models KW - Skin cancer KW - Transcription KW - Polyadenylation KW - Carcinogens KW - Tumors KW - Transgenic mice KW - Promoters KW - Globins KW - U.V. radiation KW - Ha-Ras protein KW - Reviews KW - Carcinogenesis KW - Exploration KW - Toxicity testing KW - Wounding KW - W 30925:Genetic Engineering KW - B 26130:Ras and Ras related oncogenes (Rho/Rac/Ral) KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19742040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Biological%2C+cellular%2C+and+molecular+characteristics+of+an+inducible+transgenic+skin+tumor+model%3A+a+review&rft.au=Humble%2C+M+C%3BTrempus%2C+C+S%3BSpalding%2C+J+W%3BCannon%2C+R+E%3BTennant%2C+R+W&rft.aulast=Humble&rft.aufirst=M&rft.date=2005-12-15&rft.volume=24&rft.issue=56&rft.spage=8217&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/10.1038%2Fsj.onc.1209000 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Ras protein; Molecular modelling; chromosome 11; Skin; Animal models; Transcription; Skin cancer; Polyadenylation; Tumors; Carcinogens; Transgenic mice; Globins; Promoters; U.V. radiation; Reviews; Ha-Ras protein; Carcinogenesis; Exploration; Toxicity testing; Wounding DO - http://dx.doi.org/10.1038/sj.onc.1209000 ER - TY - JOUR T1 - Cardiovascular phenotyping of fetal mice by noninvasive high-frequency ultrasound facilitates recovery of ENU-induced mutations causing congenital cardiac and extracardiac defects. AN - 68896708; 16174781 AB - As part of a large-scale noninvasive fetal ultrasound screen to recover ethylnitrosourea (ENU)-induced mutations causing congenital heart defects in mice, we established a high-throughput ultrasound scanning strategy for interrogating fetal mice in utero utilizing three orthogonal imaging planes defined by the fetus' vertebral column and body axes, structures readily seen by ultrasound. This contrasts with the difficulty of acquiring clinical ultrasound imaging planes which are defined by the fetal heart. By use of the three orthogonal imaging planes for two-dimensional (2D) imaging together with color flow, spectral Doppler, and M-mode imaging, all of the major elements of the heart can be evaluated. In this manner, 10,091 ENU-mutagenized mouse fetuses were ultrasound scanned between embryonic days 12.5 and 19.5, with 324 fetuses found to die prenatally and 425 exhibiting cardiovascular defects. Further analysis by necropsy and histology showed heart defects that included conotruncal anomalies, obstructive lesions, and shunt lesions as well as other complex heart diseases. Ultrasound imaging also identified craniofacial/head defects and body wall closure defects, which necropsy revealed as encephalocele, holoprosencephaly, omphalocele, or gastroschisis. Genome scanning mapped one ENU-induced mutation associated with persistence truncus arteriosus and holoprosencephaly to mouse chromosome 2, while another mutation associated with cardiac defects and omphalocele was mapped to mouse chromosome 17. These studies show the efficacy of this novel ultrasound scanning strategy for noninvasive ultrasound phenotyping to facilitate the recovery of ENU-induced mutations causing congenital heart defects and other extracardiac anomalies. JF - Physiological genomics AU - Shen, Yuan AU - Leatherbury, L AU - Rosenthal, J AU - Yu, Qing AU - Pappas, M A AU - Wessels, A AU - Lucas, J AU - Siegfried, B AU - Chatterjee, B AU - Svenson, Karen AU - Lo, C W AD - Laboratory of Developmental Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-8019, USA. Y1 - 2005/12/14/ PY - 2005 DA - 2005 Dec 14 SP - 23 EP - 36 VL - 24 IS - 1 KW - Ethylnitrosourea KW - P8M1T4190R KW - Index Medicus KW - Animals KW - Mice KW - Female KW - Pregnancy KW - Fetus -- radiation effects KW - Cardiovascular Physiological Phenomena KW - Ultrasonography, Prenatal KW - Heart Defects, Congenital -- diagnostic imaging KW - Ethylnitrosourea -- toxicity KW - Abnormalities, Multiple -- embryology KW - Heart Defects, Congenital -- embryology KW - Abnormalities, Multiple -- diagnostic imaging KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68896708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physiological+genomics&rft.atitle=Cardiovascular+phenotyping+of+fetal+mice+by+noninvasive+high-frequency+ultrasound+facilitates+recovery+of+ENU-induced+mutations+causing+congenital+cardiac+and+extracardiac+defects.&rft.au=Shen%2C+Yuan%3BLeatherbury%2C+L%3BRosenthal%2C+J%3BYu%2C+Qing%3BPappas%2C+M+A%3BWessels%2C+A%3BLucas%2C+J%3BSiegfried%2C+B%3BChatterjee%2C+B%3BSvenson%2C+Karen%3BLo%2C+C+W&rft.aulast=Shen&rft.aufirst=Yuan&rft.date=2005-12-14&rft.volume=24&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Physiological+genomics&rft.issn=1531-2267&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-02 N1 - Date created - 2005-12-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Role of Telomeres in Cancer and Aging: A Matter of Bad Ends T2 - 2005 Conference on Genes and Cancer AN - 39782539; 4055496 JF - 2005 Conference on Genes and Cancer AU - Blasco, Maria Y1 - 2005/12/12/ PY - 2005 DA - 2005 Dec 12 KW - Aging KW - Cancer KW - Telomeres KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39782539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Conference+on+Genes+and+Cancer&rft.atitle=Role+of+Telomeres+in+Cancer+and+Aging%3A+A+Matter+of+Bad+Ends&rft.au=Blasco%2C+Maria&rft.aulast=Blasco&rft.aufirst=Maria&rft.date=2005-12-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Conference+on+Genes+and+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://science.cancerresearchuk.org/genes_and_cancer/2005/programme?version =3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The TGF-b System in Breast Cancer: A Double-Edged Sword T2 - 2005 Conference on Genes and Cancer AN - 39730389; 4055489 JF - 2005 Conference on Genes and Cancer AU - Wakefield, Lalage Y1 - 2005/12/12/ PY - 2005 DA - 2005 Dec 12 KW - Breast cancer KW - Transforming growth factor-^b KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39730389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Conference+on+Genes+and+Cancer&rft.atitle=The+TGF-b+System+in+Breast+Cancer%3A+A+Double-Edged+Sword&rft.au=Wakefield%2C+Lalage&rft.aulast=Wakefield&rft.aufirst=Lalage&rft.date=2005-12-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Conference+on+Genes+and+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://science.cancerresearchuk.org/genes_and_cancer/2005/programme?version =3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Development of cancer chemopreventive drugs based on mechanistic approaches. AN - 68827011; 16083917 AB - One of the most important medical practices of the 21st century is the chemoprevention of cancer. Much progress has been made in this new emerging field, but much work remains before widespread use and practice of cancer prevention becomes commonplace. Cancer chemoprevention includes the concepts of inhibition, reversal, and retardation of the cancer process. The process of carcinogenesis requires 20-40 years to reach invasive cancer. This process follows multiple, diverse, and complex pathways in a stochastic process, called clonal evolution. Many of these pathways appear amenable to inhibition, reversal, or retardation at various points. It is urgent that we identify key pathways in the evolution of the cancer cell, which can be exploited to prevent this carcinogenesis process. Basic researchers are identifying many genetic lesions and epigenetic processes associated with the progression of precancer to invasive disease. These precancer lesions are also called intraepithelial neoplasia (IEN). Many of these early precancerous lesions favor cell division over quiescence and protect cells against apoptosis when signals are present. Many oncogenes, which are active during early development, are reactivated in adulthood by aberrant gene promoting errors. Normal regulatory genes can become mutated, making them insensitive to normal regulatory signals. Tumor suppressor genes are deleted or mutated rendering them inactive. These are several of a wide range of defects in cellular machinery, which can lead to evolution of the cancer phenotype. Errors may not have to appear in a defined order for cells to progress along the cancer pathway. To conquer this diverse disease, it is necessary to attack multiple key pathways at once for a predetermined period of time. Agent combination prevention strategies are, therefore, essential to decrease cancer morbidity. Each cancer type, organ location, or individual genetic background may require a custom combination of prevention strategies to be successful. JF - Mutation research AU - Steele, Vernon E AU - Kelloff, Gary J AD - National Cancer Institute, EPN 2108, MSC 7322, 9000 Rockville Pike, National Institutes of Health, Bethesda, MD 20892-7322, USA. vs1y@nih.gov Y1 - 2005/12/11/ PY - 2005 DA - 2005 Dec 11 SP - 16 EP - 23 VL - 591 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Anticarcinogenic Agents KW - 0 KW - Index Medicus KW - Humans KW - Anticarcinogenic Agents -- therapeutic use KW - Neoplasms -- prevention & control KW - Mutation KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68827011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Development+of+cancer+chemopreventive+drugs+based+on+mechanistic+approaches.&rft.au=Steele%2C+Vernon+E%3BKelloff%2C+Gary+J&rft.aulast=Steele&rft.aufirst=Vernon&rft.date=2005-12-11&rft.volume=591&rft.issue=1-2&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-15 N1 - Date created - 2005-11-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Translating Evidence-Based Practices into Health Policy: A Tool to Reduce Cancer Health Disparities T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39933087; 4084997 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Cooper, Leslie C AU - McCrae, Tarsha AU - Wingrove, Barbara K Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Cancer KW - Policies KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39933087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Translating+Evidence-Based+Practices+into+Health+Policy%3A+A+Tool+to+Reduce+Cancer+Health+Disparities&rft.au=Cooper%2C+Leslie+C%3BMcCrae%2C+Tarsha%3BWingrove%2C+Barbara+K&rft.aulast=Cooper&rft.aufirst=Leslie&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tobacco Dependence and Psychiatric Comorbidity: Possible Mechanisms of Association T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39922692; 4085209 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Riley, William Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Tobacco KW - Morbidity KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39922692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Tobacco+Dependence+and+Psychiatric+Comorbidity%3A+Possible+Mechanisms+of+Association&rft.au=Riley%2C+William&rft.aulast=Riley&rft.aufirst=William&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Education Level and Drinking Behavior Among Racial/Ethnic Groups: Results from the 20012002 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39920939; 4085275 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Yoon, Young-Hee AU - Yi, Hsiao-ye AU - Chen, Chiung M AU - Breslow, Rosalind Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Alcohols KW - Ethnic groups KW - Education KW - Drinking behavior KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39920939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Education+Level+and+Drinking+Behavior+Among+Racial%2FEthnic+Groups%3A+Results+from+the+20012002+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions+%28NESARC%29&rft.au=Yoon%2C+Young-Hee%3BYi%2C+Hsiao-ye%3BChen%2C+Chiung+M%3BBreslow%2C+Rosalind&rft.aulast=Yoon&rft.aufirst=Young-Hee&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - More Research will not Solve Health Disparities; Using Health Policy to Sustain Evidence-Based Practices T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39867618; 4084998 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Wingrove, Barbara K Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Policies KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39867618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=More+Research+will+not+Solve+Health+Disparities%3B+Using+Health+Policy+to+Sustain+Evidence-Based+Practices&rft.au=Wingrove%2C+Barbara+K&rft.aulast=Wingrove&rft.aufirst=Barbara&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fruit and Vegetable Consumption Among African American Adult Males: Correlates of Awareness and Consumption T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39852048; 4086733 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Robinson, JaMuir M AU - Massett, Holly AU - DiSogra, Lorelei AU - Moser, Richard P AU - Maibach, Edward AU - Weber, Deanne Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Africa KW - Ethnic groups KW - Vegetables KW - Fruits KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39852048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Fruit+and+Vegetable+Consumption+Among+African+American+Adult+Males%3A+Correlates+of+Awareness+and+Consumption&rft.au=Robinson%2C+JaMuir+M%3BMassett%2C+Holly%3BDiSogra%2C+Lorelei%3BMoser%2C+Richard+P%3BMaibach%2C+Edward%3BWeber%2C+Deanne&rft.aulast=Robinson&rft.aufirst=JaMuir&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Promoting the Body and Soul Program: Lessons Learned from the Nationwide Dissemination of a Health Promotion Program for African American Churches T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39851922; 4088585 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Williams, Alexis M AU - DiSogra, Lorelei Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Africa KW - Health promotion KW - Ethnic groups KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39851922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Injury+Prevention&rft.atitle=Factors+associated+with+bicycle+helmet+use+among+young+adolescents+in+a+multinational+sample&rft.au=Klein%2C+K+S%3BThompson%2C+D%3BScheidt%2C+P+C%3BOverpeck%2C+M+D%3BGross%2C+L+A&rft.aulast=Klein&rft.aufirst=K&rft.date=2005-10-01&rft.volume=11&rft.issue=5&rft.spage=288&rft.isbn=&rft.btitle=&rft.title=Injury+Prevention&rft.issn=13538047&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Associations Between Craving for Tobacco Cigarettes and Illicit Drugs T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39850588; 4085208 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Heishman, Stephen J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Tobacco KW - Drug addiction KW - Cigarettes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39850588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Associations+Between+Craving+for+Tobacco+Cigarettes+and+Illicit+Drugs&rft.au=Heishman%2C+Stephen+J&rft.aulast=Heishman&rft.aufirst=Stephen&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Community Environmnetal forum Theater: Tox and Risk Take the Stage T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39849469; 4086242 DE: JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Sullivan, john Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39849469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Community+Environmnetal+forum+Theater%3A+Tox+and+Risk+Take+the+Stage&rft.au=Sullivan%2C+john&rft.aulast=Sullivan&rft.aufirst=john&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of the Checkpoints Program on Parent-Imposed Driving Limits and Crash Outcomes Among Novice Teen Drivers at 6-Months Post-Licensure T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39842823; 4087776 DE: JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Simons-Morton, Bruce G Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39842823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Effects+of+the+Checkpoints+Program+on+Parent-Imposed+Driving+Limits+and+Crash+Outcomes+Among+Novice+Teen+Drivers+at+6-Months+Post-Licensure&rft.au=Simons-Morton%2C+Bruce+G&rft.aulast=Simons-Morton&rft.aufirst=Bruce&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of the Adaptations Index for Women with Pelvic Floor Disorders: The Value of the Patients Voice T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39842613; 4088642 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Wren, Patricia A Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Adaptations KW - Pelvis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39842613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Development+of+the+Adaptations+Index+for+Women+with+Pelvic+Floor+Disorders%3A+The+Value+of+the+Patients+Voice&rft.au=Wren%2C+Patricia+A&rft.aulast=Wren&rft.aufirst=Patricia&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Public Health in Public Housing: Improving Health, Changing Lives Results of a Strategic Planning Workshop to Address CVD and Asthma in Public Housing Settings T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39841833; 4088475 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Simon, Lenee N AU - Fulwood, Robinson AU - Morosco, Gregory J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Housing KW - Respiratory diseases KW - Asthma KW - Public health KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39841833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Public+Health+in+Public+Housing%3A+Improving+Health%2C+Changing+Lives+Results+of+a+Strategic+Planning+Workshop+to+Address+CVD+and+Asthma+in+Public+Housing+Settings&rft.au=Simon%2C+Lenee+N%3BFulwood%2C+Robinson%3BMorosco%2C+Gregory+J&rft.aulast=Simon&rft.aufirst=Lenee&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evidence Base for Cancer Screening Promotion: How Good a Fit for Public Health Practice? T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39833430; 4086007 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Breen, Nancy AU - Meissner, Helen Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Public health KW - Cancer KW - Screening KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39833430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Evidence+Base+for+Cancer+Screening+Promotion%3A+How+Good+a+Fit+for+Public+Health+Practice%3F&rft.au=Breen%2C+Nancy%3BMeissner%2C+Helen&rft.aulast=Breen&rft.aufirst=Nancy&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Dynamic Panel Study of the Linkages Between Smoking Behavior and Health Expenditures T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39828536; 4085326 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Shaw, James W AU - Horrace, William C Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Smoking KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39828536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=A+Dynamic+Panel+Study+of+the+Linkages+Between+Smoking+Behavior+and+Health+Expenditures&rft.au=Shaw%2C+James+W%3BHorrace%2C+William+C&rft.aulast=Shaw&rft.aufirst=James&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Drinking Patterns of Recovering Alcoholics: Results from the 20012002 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39828092; 4085235 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Chen, Chiung M AU - Yi, Hsiao-ye AU - Hilton, Michael E Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Alcohols KW - Ethanol KW - Alcoholics KW - Drinking KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39828092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Drinking+Patterns+of+Recovering+Alcoholics%3A+Results+from+the+20012002+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions+%28NESARC%29&rft.au=Chen%2C+Chiung+M%3BYi%2C+Hsiao-ye%3BHilton%2C+Michael+E&rft.aulast=Chen&rft.aufirst=Chiung&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Software for Survival Analysis of Studies Nested within Cohorts to Estimate Relative, Absolute, and Attributable Risks T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39827192; 4086582 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Katki, Hormuzd AU - Mark, Steven D Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Computer programs KW - Software KW - Survival KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39827192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Software+for+Survival+Analysis+of+Studies+Nested+within+Cohorts+to+Estimate+Relative%2C+Absolute%2C+and+Attributable+Risks&rft.au=Katki%2C+Hormuzd%3BMark%2C+Steven+D&rft.aulast=Katki&rft.aufirst=Hormuzd&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vesicular Trafficking And Signal Relay During Chemotaxis T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39824367; 4033803 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Kriebel, P W AU - Barr, V A AU - Mihaylov, V A AU - Parent, C A Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Chemotaxis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39824367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Vesicular+Trafficking+And+Signal+Relay+During+Chemotaxis&rft.au=Kriebel%2C+P+W%3BBarr%2C+V+A%3BMihaylov%2C+V+A%3BParent%2C+C+A&rft.aulast=Kriebel&rft.aufirst=P&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Look at Patterns of Tobacco and Alcohol Comorbidities in the U.S. Population T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39821741; 4085206 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Chiapella, Page AU - Fertig, Joanne Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - USA KW - Alcohols KW - Tobacco KW - Morbidity KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39821741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Glia&rft.atitle=Interactive+role+of+the+toll-like+receptor+4+and+reactive+oxygen+species+in+LPS-induced+microglia+activation.&rft.au=Qin%2C+Liya%3BLi%2C+Guorong%3BQian%2C+Xun%3BLiu%2C+Yuxin%3BWu%2C+Xuefei%3BLiu%2C+Bin%3BHong%2C+Jau-Shyong%3BBlock%2C+Michelle+L&rft.aulast=Qin&rft.aufirst=Liya&rft.date=2005-10-01&rft.volume=52&rft.issue=1&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=Glia&rft.issn=08941491&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Poverty, Perceived Discrimination, and Parenting Stress in African American mothers of Young Children T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39821163; 4088302 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Siefert, Kristine AU - Finlayson, Tracy L AU - Ismail, Amid AU - Delva, Jorge AU - Williams, David R AU - Amaya, Ashley AU - Lepkowski, James Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Africa KW - Children KW - Stress KW - Discrimination KW - Ethnic groups KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39821163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Poverty%2C+Perceived+Discrimination%2C+and+Parenting+Stress+in+African+American+mothers+of+Young+Children&rft.au=Siefert%2C+Kristine%3BFinlayson%2C+Tracy+L%3BIsmail%2C+Amid%3BDelva%2C+Jorge%3BWilliams%2C+David+R%3BAmaya%2C+Ashley%3BLepkowski%2C+James&rft.aulast=Siefert&rft.aufirst=Kristine&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cigarette Smoking Among Low-Income African American Women: A Hidden, Neglected, and Growing Public Health Problem T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39820661; 4085417 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Delva, Jorge AU - Tellez, Marisol AU - Finlayson, Tracy L AU - Gretebeck, Kimberlee AU - Siefert, Kristine AU - Williams, David R AU - Ismail, Amid Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Africa KW - Public health KW - Socio-economic aspects KW - Ethnic groups KW - Cigarette smoking KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39820661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Cigarette+Smoking+Among+Low-Income+African+American+Women%3A+A+Hidden%2C+Neglected%2C+and+Growing+Public+Health+Problem&rft.au=Delva%2C+Jorge%3BTellez%2C+Marisol%3BFinlayson%2C+Tracy+L%3BGretebeck%2C+Kimberlee%3BSiefert%2C+Kristine%3BWilliams%2C+David+R%3BIsmail%2C+Amid&rft.aulast=Delva&rft.aufirst=Jorge&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NIDCR: Addressing Oral Health Disparities through Research T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39820229; 4086116 DE: JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Nowjack-Raymer, Ruth Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39820229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=NIDCR%3A+Addressing+Oral+Health+Disparities+through+Research&rft.au=Nowjack-Raymer%2C+Ruth&rft.aulast=Nowjack-Raymer&rft.aufirst=Ruth&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuroglia Specific Expression of a FRET-based Calcium Indicator in Transgenic Mice T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39819514; 4033516 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Atkin, S D AU - Holtzclaw, L A AU - Pickel, J M AU - Russell, J T Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Mice KW - Calcium KW - Transgenic mice KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39819514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Neuroglia+Specific+Expression+of+a+FRET-based+Calcium+Indicator+in+Transgenic+Mice&rft.au=Atkin%2C+S+D%3BHoltzclaw%2C+L+A%3BPickel%2C+J+M%3BRussell%2C+J+T&rft.aulast=Atkin&rft.aufirst=S&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Changes in Chromatin Structure and Mobility in Living Cells at Sites of DNA Double-strand Breaks T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39818552; 4033320 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Kruhlak, M J AU - Celeste, A AU - Fernandez-Capetillo, O AU - Dellaire, AU - Muller, G W AU - McNally, J G AU - Bazett-Jones, D P AU - Nussenzweig, A Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Mobility KW - Chromatin KW - DNA damage KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39818552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Changes+in+Chromatin+Structure+and+Mobility+in+Living+Cells+at+Sites+of+DNA+Double-strand+Breaks&rft.au=Kruhlak%2C+M+J%3BCeleste%2C+A%3BFernandez-Capetillo%2C+O%3BDellaire%2C%3BMuller%2C+G+W%3BMcNally%2C+J+G%3BBazett-Jones%2C+D+P%3BNussenzweig%2C+A&rft.aulast=Kruhlak&rft.aufirst=M&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Unexpected Role of Bcl-2 Family Members in Mitochondrial Morphogenesis T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39818238; 4032445 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Youle, R J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Morphogenesis KW - Bcl-2 protein KW - Mitochondria KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39818238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=An+Unexpected+Role+of+Bcl-2+Family+Members+in+Mitochondrial+Morphogenesis&rft.au=Youle%2C+R+J&rft.aulast=Youle&rft.aufirst=R&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Diet, Activity, and Smoking: What do Data from Various Studies Reveal Regarding Their Relation? T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39817239; 4085207 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Augustson, Erik M AU - Wanke, Kay L AU - Bergen, Andrew W AU - Lanza, Elaine AU - Caporaso, Neil E Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Smoking KW - Diets KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39817239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Diet%2C+Activity%2C+and+Smoking%3A+What+do+Data+from+Various+Studies+Reveal+Regarding+Their+Relation%3F&rft.au=Augustson%2C+Erik+M%3BWanke%2C+Kay+L%3BBergen%2C+Andrew+W%3BLanza%2C+Elaine%3BCaporaso%2C+Neil+E&rft.aulast=Augustson&rft.aufirst=Erik&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hemoglobin Genotype-dependent Erythrocyte Membrane Potential Correlates to Innate Protection Against Severe Malaria T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39816027; 4033579 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Tokumasu, F AU - Dvorak, J A Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Malaria KW - Membrane potential KW - Hemoglobin KW - Erythrocytes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39816027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Hemoglobin+Genotype-dependent+Erythrocyte+Membrane+Potential+Correlates+to+Innate+Protection+Against+Severe+Malaria&rft.au=Tokumasu%2C+F%3BDvorak%2C+J+A&rft.aulast=Tokumasu&rft.aufirst=F&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modeling the Relationship Between Healthy People 2010 Upstream (Risk Factors and Screening) and Downstream (Mortality) Goals for Cancer T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39815446; 4086564 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Feuer, Eric J AU - Cronin, Kathleen Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Mortality KW - Cancer KW - Risk factors KW - Screening KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39815446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Modeling+the+Relationship+Between+Healthy+People+2010+Upstream+%28Risk+Factors+and+Screening%29+and+Downstream+%28Mortality%29+Goals+for+Cancer&rft.au=Feuer%2C+Eric+J%3BCronin%2C+Kathleen&rft.aulast=Feuer&rft.aufirst=Eric&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lessons Learned: Environmental Health Information Outreach to Native Americans T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39813844; 4086281 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Love, Cynthia AU - Dutcher, Gale AU - Arnesen, Stacey J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Ethnic groups KW - Environmental health KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39813844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Lessons+Learned%3A+Environmental+Health+Information+Outreach+to+Native+Americans&rft.au=Love%2C+Cynthia%3BDutcher%2C+Gale%3BArnesen%2C+Stacey+J&rft.aulast=Love&rft.aufirst=Cynthia&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Plasma Membrane ABCG1 Mediates Cellular Cholesterol Efflux to Lipoproteins T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39812018; 4034682 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Neufeld, E B AU - O'Brien, K AU - Demosky, S J AU - Stonik, J A AU - Sabol, S L AU - Malide, D AU - Combs, C A AU - Remaley, A T AU - Santamaina-Fojo, S AU - Brewer, H B Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Cholesterol KW - Plasma membranes KW - Lipoproteins KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39812018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Plasma+Membrane+ABCG1+Mediates+Cellular+Cholesterol+Efflux+to+Lipoproteins&rft.au=Neufeld%2C+E+B%3BO%27Brien%2C+K%3BDemosky%2C+S+J%3BStonik%2C+J+A%3BSabol%2C+S+L%3BMalide%2C+D%3BCombs%2C+C+A%3BRemaley%2C+A+T%3BSantamaina-Fojo%2C+S%3BBrewer%2C+H+B&rft.aulast=Neufeld&rft.aufirst=E&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of DetaD Endocytosis and Recycling T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39811741; 4034633 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Palardy, G AU - Goswami, M AU - Chitnis, A Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Protein turnover KW - Recycling KW - Endocytosis KW - Waste management KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39811741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Characterization+of+DetaD+Endocytosis+and+Recycling&rft.au=Palardy%2C+G%3BGoswami%2C+M%3BChitnis%2C+A&rft.aulast=Palardy&rft.aufirst=G&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - What Do Alcohol, Tobacco, Other Drugs, Physical Inactivity, and Mental Health Disorders Have in Common? T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39806038; 4085205 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Backinger, Cathy L AU - Chiapella, Page AU - Augustson, Erik M AU - Heishman, Stephen J AU - Riley, William Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Physical activity KW - Alcohols KW - Tobacco KW - Drugs KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39806038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=What+Do+Alcohol%2C+Tobacco%2C+Other+Drugs%2C+Physical+Inactivity%2C+and+Mental+Health+Disorders+Have+in+Common%3F&rft.au=Backinger%2C+Cathy+L%3BChiapella%2C+Page%3BAugustson%2C+Erik+M%3BHeishman%2C+Stephen+J%3BRiley%2C+William&rft.aulast=Backinger&rft.aufirst=Cathy&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Level and Concentration of Alcohol Consumption by Beverage Type and Demographic Characteristics: Results from the 20012002 NESARC T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39774878; 4085239 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Yi, Hsiao-ye AU - Chen, Chiung M AU - Hilton, Michael E Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Alcohols KW - Ethanol KW - Demography KW - Beverages KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39774878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Level+and+Concentration+of+Alcohol+Consumption+by+Beverage+Type+and+Demographic+Characteristics%3A+Results+from+the+20012002+NESARC&rft.au=Yi%2C+Hsiao-ye%3BChen%2C+Chiung+M%3BHilton%2C+Michael+E&rft.aulast=Yi&rft.aufirst=Hsiao-ye&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=0301472X&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Taking a Systems Approach to Tobacco Research: Modeling Dynamic Processes for a Complex World T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39773539; 4085324 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Leischow, Scott J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Tobacco KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39773539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Taking+a+Systems+Approach+to+Tobacco+Research%3A+Modeling+Dynamic+Processes+for+a+Complex+World&rft.au=Leischow%2C+Scott+J&rft.aulast=Leischow&rft.aufirst=Scott&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multi-Morbid DSM-IV Axis I Psychological and Axis II Personality Disorders and Their Association with Substance Use Disorders and Hazardous Drinking: Results from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39768732; 4085237 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Falk, Daniel E AU - Yi, Hsiao-ye AU - Breslow, Rosalind Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Psychology KW - Alcohols KW - Personality KW - Drinking KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39768732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Multi-Morbid+DSM-IV+Axis+I+Psychological+and+Axis+II+Personality+Disorders+and+Their+Association+with+Substance+Use+Disorders+and+Hazardous+Drinking%3A+Results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions+%28NESARC%29&rft.au=Falk%2C+Daniel+E%3BYi%2C+Hsiao-ye%3BBreslow%2C+Rosalind&rft.aulast=Falk&rft.aufirst=Daniel&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Question of Whether DSM-IV Alcohol Dependence is a Categorical or a Continuous Variable T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39768696; 4085236 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Yahr, Harold T Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Alcohols KW - Drug dependence KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39768696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Question+of+Whether+DSM-IV+Alcohol+Dependence+is+a+Categorical+or+a+Continuous+Variable&rft.au=Yahr%2C+Harold+T&rft.aulast=Yahr&rft.aufirst=Harold&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interactions between HIV-1 and HIV-2 Gag Polyproteins in vivo T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39765071; 4035164 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Boyko, V P Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Polyproteins KW - Human immunodeficiency virus 2 KW - Human immunodeficiency virus 1 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39765071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Interactions+between+HIV-1+and+HIV-2+Gag+Polyproteins+in+vivo&rft.au=Boyko%2C+V+P&rft.aulast=Boyko&rft.aufirst=V&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Findings from the National Cancer Institute and Vietnamese American Medical Association Pap Test Barriers Survey for Health Care Providers T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39765038; 4087930 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Solomon, Felicia M AU - DeJoice, Rhonda W AU - Nguyen, Si V AU - Kwon, Harry T AU - Berlin, Nina Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Health care KW - Cancer KW - Barriers KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39765038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Findings+from+the+National+Cancer+Institute+and+Vietnamese+American+Medical+Association+Pap+Test+Barriers+Survey+for+Health+Care+Providers&rft.au=Solomon%2C+Felicia+M%3BDeJoice%2C+Rhonda+W%3BNguyen%2C+Si+V%3BKwon%2C+Harry+T%3BBerlin%2C+Nina&rft.aulast=Solomon&rft.aufirst=Felicia&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Disparities in the Consequences of Drug Use Among Minority Populations: Need for Culture-Specific Interventions T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39764894; 4085611 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Jones, Dionne AU - Fernandez, M Isabel AU - Harrison, Murelle G AU - McCoy, Clyde B AU - Devieux, Jessy G Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Drug abuse KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39764894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Disparities+in+the+Consequences+of+Drug+Use+Among+Minority+Populations%3A+Need+for+Culture-Specific+Interventions&rft.au=Jones%2C+Dionne%3BFernandez%2C+M+Isabel%3BHarrison%2C+Murelle+G%3BMcCoy%2C+Clyde+B%3BDevieux%2C+Jessy+G&rft.aulast=Jones&rft.aufirst=Dionne&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural Mechanism for Sterol Sensing and Transport by OSBP-related Proteins T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39764795; 4033929 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Im, Y. AU - Raychaudhuri, S AU - Prinz, W A AU - Hurley, J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Sterols KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39764795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Structural+Mechanism+for+Sterol+Sensing+and+Transport+by+OSBP-related+Proteins&rft.au=Im%2C+Y.%3BRaychaudhuri%2C+S%3BPrinz%2C+W+A%3BHurley%2C+J&rft.aulast=Im&rft.aufirst=Y.&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oral Cancer Knowledge, Attitudes, and Behaviors of At-Risk African American Men in Washington, D.C T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39760676; 4088377 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Boehm, Karina AU - Daum, Mary AU - Bobbin, Marilyn Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - USA, Washington KW - Africa KW - Ethnic groups KW - Cancer KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39760676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Oral+Cancer+Knowledge%2C+Attitudes%2C+and+Behaviors+of+At-Risk+African+American+Men+in+Washington%2C+D.C&rft.au=Boehm%2C+Karina%3BDaum%2C+Mary%3BBobbin%2C+Marilyn&rft.aulast=Boehm&rft.aufirst=Karina&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - National Cancer Institute's Cancer Information Service Research Program: Integrating Health Communication Research into Service T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39759349; 4088442 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Vanderpool, Robin Cline AU - Squiers, Linda Brafford Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Cancer KW - Communication KW - Research programs KW - Information services KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39759349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=National+Cancer+Institute%27s+Cancer+Information+Service+Research+Program%3A+Integrating+Health+Communication+Research+into+Service&rft.au=Vanderpool%2C+Robin+Cline%3BSquiers%2C+Linda+Brafford&rft.aulast=Vanderpool&rft.aufirst=Robin&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Thread-to-Grain Transition of Mitochondria Induced by Cytomegalovirus-Encoded vMIA is Independent of Pro-Apoptotic Bcl-2 Family Member, Bax T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39756524; 4033519 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Norris, K L AU - Karbowski, M AU - Dlouhy, B AU - Youle, R J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Bax protein KW - Bcl-2 protein KW - Mitochondria KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39756524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Thread-to-Grain+Transition+of+Mitochondria+Induced+by+Cytomegalovirus-Encoded+vMIA+is+Independent+of+Pro-Apoptotic+Bcl-2+Family+Member%2C+Bax&rft.au=Norris%2C+K+L%3BKarbowski%2C+M%3BDlouhy%2C+B%3BYoule%2C+R+J&rft.aulast=Norris&rft.aufirst=K&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chromogranin A Deficiency in Transgenic Mice Leads to Aberrant Chromaffin Granule Biogenesis T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39755746; 4033498 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Kim, T AU - Zhang, C AU - Sun, Z AU - Wu, H. AU - Loh, Y P Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Chromaffin granules KW - Biogenesis KW - Mice KW - Chromogranins KW - Evolution KW - Transgenic mice KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39755746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Chromogranin+A+Deficiency+in+Transgenic+Mice+Leads+to+Aberrant+Chromaffin+Granule+Biogenesis&rft.au=Kim%2C+T%3BZhang%2C+C%3BSun%2C+Z%3BWu%2C+H.%3BLoh%2C+Y+P&rft.aulast=Kim&rft.aufirst=T&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MAD1 Haplo-insufficiency and Tumor Development in Mice T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39755181; 4033379 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Iwanaga, Y AU - Miyazato, A AU - Chi, Y AU - Haller, K AU - Ward, J M AU - Jeang, K Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Mice KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39755181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=MAD1+Haplo-insufficiency+and+Tumor+Development+in+Mice&rft.au=Iwanaga%2C+Y%3BMiyazato%2C+A%3BChi%2C+Y%3BHaller%2C+K%3BWard%2C+J+M%3BJeang%2C+K&rft.aulast=Iwanaga&rft.aufirst=Y&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Patient Recruitment to a Phase III Complementary and Alternative Medicine Clinical Trial: Overcoming Challenges T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39753698; 4088092 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Cotler, Alyssa AU - Arciniega, Jacqueline AU - Doner, Lynne AU - Lange, Amy AU - Liu, Irene AU - Nahin, Richard AU - Tisch, Jennifer AU - Lamas, Gervasio AU - Lambe, Lindsay AU - Clapp-Channing, Nancy Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Clinical trials KW - Recruitment KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39753698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Patient+Recruitment+to+a+Phase+III+Complementary+and+Alternative+Medicine+Clinical+Trial%3A+Overcoming+Challenges&rft.au=Cotler%2C+Alyssa%3BArciniega%2C+Jacqueline%3BDoner%2C+Lynne%3BLange%2C+Amy%3BLiu%2C+Irene%3BNahin%2C+Richard%3BTisch%2C+Jennifer%3BLamas%2C+Gervasio%3BLambe%2C+Lindsay%3BClapp-Channing%2C+Nancy&rft.aulast=Cotler&rft.aufirst=Alyssa&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ezrin is Activated by PKC and Contributes to Metastatic Phenotype of Osteosarcoma Cells T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39752698; 4032573 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Ren, L AU - Hong, S AU - Cassavaugh, J AU - Khanna, C Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Ezrin KW - Osteosarcoma cells KW - Phenotypes KW - Metastases KW - Protein kinase C KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39752698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Ezrin+is+Activated+by+PKC+and+Contributes+to+Metastatic+Phenotype+of+Osteosarcoma+Cells&rft.au=Ren%2C+L%3BHong%2C+S%3BCassavaugh%2C+J%3BKhanna%2C+C&rft.aulast=Ren&rft.aufirst=L&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Perturbation of the Endocytic Pathway Affects Expression and Translocation of Salmonella-effector Proteins in Cultured Epithelial Cells T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39744792; 4033598 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Fuentes, P AU - Drecktrah, D AU - Knodler, L A AU - Steele-Mortimer, O Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Translocation KW - Fish culture KW - Epithelial cells KW - Salmonidae KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39744792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Perturbation+of+the+Endocytic+Pathway+Affects+Expression+and+Translocation+of+Salmonella-effector+Proteins+in+Cultured+Epithelial+Cells&rft.au=Fuentes%2C+P%3BDrecktrah%2C+D%3BKnodler%2C+L+A%3BSteele-Mortimer%2C+O&rft.aulast=Fuentes&rft.aufirst=P&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a Polarized Epithelial Cell Model to Study the Role of Akt/PKB in Salmonella Enterica Interactions with the Intestinal Epithelium T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39744709; 4033597 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Ireland, R AU - Steele-Mortimer, O Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Intestine KW - Cell culture KW - Epithelium KW - AKT protein KW - Epithelial cells KW - Salmonella enterica KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39744709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Development+of+a+Polarized+Epithelial+Cell+Model+to+Study+the+Role+of+Akt%2FPKB+in+Salmonella+Enterica+Interactions+with+the+Intestinal+Epithelium&rft.au=Ireland%2C+R%3BSteele-Mortimer%2C+O&rft.aulast=Ireland&rft.aufirst=R&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2005.03.009 L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - K-165: An Organelle Motor in the Squid Giant Axon T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39741974; 4034277 JF - 45th Annual Meeting of the American Society for Cell Biology AU - DeGiorgis, J A AU - Gallant, P E AU - Reese, T S AU - Galbraith, J A Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Organelles KW - Neurons KW - Giant axons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39741974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=K-165%3A+An+Organelle+Motor+in+the+Squid+Giant+Axon&rft.au=DeGiorgis%2C+J+A%3BGallant%2C+P+E%3BReese%2C+T+S%3BGalbraith%2C+J+A&rft.aulast=DeGiorgis&rft.aufirst=J&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fibroblast Growth Factor (FGF) Signaling Regulates the Expression and the Activity of Matrix Metalloproteases (MMPs) during Mouse Submandibular Gland (SMG) Branching Morphogenesis T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39738747; 4034884 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Rebustini, I T AU - Hoffman, M P Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Fibroblast growth factor KW - Morphogenesis KW - Glands KW - Signal transduction KW - Submandibular gland KW - Matrix metalloproteinase KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39738747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Fibroblast+Growth+Factor+%28FGF%29+Signaling+Regulates+the+Expression+and+the+Activity+of+Matrix+Metalloproteases+%28MMPs%29+during+Mouse+Submandibular+Gland+%28SMG%29+Branching+Morphogenesis&rft.au=Rebustini%2C+I+T%3BHoffman%2C+M+P&rft.aulast=Rebustini&rft.aufirst=I&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Curing of Yeast [PSI@@u+@] Prion by Guanidine Inactivation of Hsp104 Does Not Require Cell Division T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39736717; 4034737 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Wu, Y. AU - Greene, L E AU - Masison, D C AU - Eisenberg, E Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Curing KW - Cell division KW - Prion protein KW - Guanidine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39736717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Curing+of+Yeast+%5BPSI%40%40u%2B%40%5D+Prion+by+Guanidine+Inactivation+of+Hsp104+Does+Not+Require+Cell+Division&rft.au=Wu%2C+Y.%3BGreene%2C+L+E%3BMasison%2C+D+C%3BEisenberg%2C+E&rft.aulast=Wu&rft.aufirst=Y.&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Expression of Cdh23 Isoforms in the Cochlea and Retina of Wild Type and Waltzer Mice T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39735260; 4034899 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Lagziel, A AU - Ahmed, Z M AU - Peters, L M AU - Friedman, T B AU - Morell, R J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Mice KW - Cochlea KW - Retina KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39735260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Differential+Expression+of+Cdh23+Isoforms+in+the+Cochlea+and+Retina+of+Wild+Type+and+Waltzer+Mice&rft.au=Lagziel%2C+A%3BAhmed%2C+Z+M%3BPeters%2C+L+M%3BFriedman%2C+T+B%3BMorell%2C+R+J&rft.aulast=Lagziel&rft.aufirst=A&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Conditional Ablation of Nonmuscle Myosin II-B in the Mouse Heart T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39733297; 4032757 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Singh, A K AU - Wei, Q AU - Takeda, K AU - Zerfas, P AU - Birdsall, C AU - Sidenko, S AU - Adelstein, R S Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Myosin KW - Ablation KW - Heart KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39733297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Conditional+Ablation+of+Nonmuscle+Myosin+II-B+in+the+Mouse+Heart&rft.au=Singh%2C+A+K%3BWei%2C+Q%3BTakeda%2C+K%3BZerfas%2C+P%3BBirdsall%2C+C%3BSidenko%2C+S%3BAdelstein%2C+R+S&rft.aulast=Singh&rft.aufirst=A&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of GlUT1 in HTLV Infection T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39733146; 4033753 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Lisinski, I M AU - Takenouchi, N AU - Kazunori, F AU - Yao, K AU - Ruscetti, F W AU - Jones, K AU - Cushman, S W AU - Jacobsen, S Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Infection KW - Human T-lymphotropic virus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39733146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Role+of+GlUT1+in+HTLV+Infection&rft.au=Lisinski%2C+I+M%3BTakenouchi%2C+N%3BKazunori%2C+F%3BYao%2C+K%3BRuscetti%2C+F+W%3BJones%2C+K%3BCushman%2C+S+W%3BJacobsen%2C+S&rft.aulast=Lisinski&rft.aufirst=I&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Six1 Promotes Rhabdomyosarcoma Metastasis through Ezrin T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39732291; 4033855 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Yu, Y. Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Ezrin KW - Metastases KW - Rhabdomyosarcoma KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39732291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Six1+Promotes+Rhabdomyosarcoma+Metastasis+through+Ezrin&rft.au=Yu%2C+Y.&rft.aulast=Yu&rft.aufirst=Y.&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Examination of Endothelial Lumenization Processes in vivo Using Zebrafish Danio rerio T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39732155; 4033835 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Kamei, M AU - Bayless, K J AU - Davis, G E AU - Weinstein, B M Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Freshwater fish KW - Danio rerio KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39732155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Examination+of+Endothelial+Lumenization+Processes+in+vivo+Using+Zebrafish+Danio+rerio&rft.au=Kamei%2C+M%3BBayless%2C+K+J%3BDavis%2C+G+E%3BWeinstein%2C+B+M&rft.aulast=Kamei&rft.aufirst=M&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Targeted Disruption of N-RAP Gene Function by RNA Interference: A Role for N-RAP in Myofibril Organization T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39727805; 4034257 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Dhume, A AU - Horowits, R Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - RNA-mediated interference KW - Myofibrils KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39727805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Targeted+Disruption+of+N-RAP+Gene+Function+by+RNA+Interference%3A+A+Role+for+N-RAP+in+Myofibril+Organization&rft.au=Dhume%2C+A%3BHorowits%2C+R&rft.aulast=Dhume&rft.aufirst=A&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Centrosome and Golgi Complex Reorganization during Myogenesis Can Proceed without a Coherent, Dynamic Microtubule Network T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39727518; 4033718 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Zaal, K J M AU - Reid, E AU - Gundersen, G G AU - Zhang, T AU - Ralston, E Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Microtubules KW - Golgi apparatus KW - Myogenesis KW - Centrosomes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39727518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Centrosome+and+Golgi+Complex+Reorganization+during+Myogenesis+Can+Proceed+without+a+Coherent%2C+Dynamic+Microtubule+Network&rft.au=Zaal%2C+K+J+M%3BReid%2C+E%3BGundersen%2C+G+G%3BZhang%2C+T%3BRalston%2C+E&rft.aulast=Zaal&rft.aufirst=K+J&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transcription Factor Sp3 and DNA Methylation Regulate the Nonmuscle Myosin Heavy Chain II-C Promoter T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39726235; 4032759 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Chung, M AU - Adelstein, R S AU - Kawamoto, S Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - DNA methylation KW - Promoters KW - Myosin KW - Transcription factors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39726235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Transcription+Factor+Sp3+and+DNA+Methylation+Regulate+the+Nonmuscle+Myosin+Heavy+Chain+II-C+Promoter&rft.au=Chung%2C+M%3BAdelstein%2C+R+S%3BKawamoto%2C+S&rft.aulast=Chung&rft.aufirst=M&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reduction of ss-Integrin Expression and Cell Attachments in Nonmucle Myosin II-B Null Mouse Embryonic Fibroblasts T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39726194; 4032755 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Kim, K AU - Adelstein, R S Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Myosin KW - Embryo fibroblasts KW - Embryos KW - Fibroblasts KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39726194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Reduction+of+ss-Integrin+Expression+and+Cell+Attachments+in+Nonmucle+Myosin+II-B+Null+Mouse+Embryonic+Fibroblasts&rft.au=Kim%2C+K%3BAdelstein%2C+R+S&rft.aulast=Kim&rft.aufirst=K&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cellular Regulation of the Hematopoietic Stem Cell Niche T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39726156; 4033097 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Gillette, J M AU - Lippincott-Schwartz, J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Stem cells KW - Niches KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39726156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Cellular+Regulation+of+the+Hematopoietic+Stem+Cell+Niche&rft.au=Gillette%2C+J+M%3BLippincott-Schwartz%2C+J&rft.aulast=Gillette&rft.aufirst=J&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a Novel Monoclonal Antibody to a Cell Surface Antigen that Isolates Neuronal Stem Cells From Murine and Pig Adult Skeletal Muscle and Murine Embryo T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39724401; 4034658 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Winitsky, S O AU - Gopal, T V AU - Hassanzadeh, S AU - Kassahun, Y A AU - Epstein, N D Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Stem cells KW - Skeletal muscle KW - Embryos KW - Monoclonal antibodies KW - Antigens KW - Cell surface KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39724401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Identification+of+a+Novel+Monoclonal+Antibody+to+a+Cell+Surface+Antigen+that+Isolates+Neuronal+Stem+Cells+From+Murine+and+Pig+Adult+Skeletal+Muscle+and+Murine+Embryo&rft.au=Winitsky%2C+S+O%3BGopal%2C+T+V%3BHassanzadeh%2C+S%3BKassahun%2C+Y+A%3BEpstein%2C+N+D&rft.aulast=Winitsky&rft.aufirst=S&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Sub-cellular Localization of NGEP, a Prostate Specific Protein in Two Prostate Cancer Cell Lines. T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39724094; 4033191 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Das, S AU - Nagata, S AU - Bera, T AU - Pastan, I Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Tumor cell lines KW - Prostate cancer KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39724094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Differential+Sub-cellular+Localization+of+NGEP%2C+a+Prostate+Specific+Protein+in+Two+Prostate+Cancer+Cell+Lines.&rft.au=Das%2C+S%3BNagata%2C+S%3BBera%2C+T%3BPastan%2C+I&rft.aulast=Das&rft.aufirst=S&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Elucidating the Structural Role of Dnm1 in Mitochondrial Fission T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39723804; 4034508 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Mears, J A AU - Ingerman, E AU - Marino, M AU - Nunnari, J AU - Hinshaw, J E Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Mitochondria KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39723804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Elucidating+the+Structural+Role+of+Dnm1+in+Mitochondrial+Fission&rft.au=Mears%2C+J+A%3BIngerman%2C+E%3BMarino%2C+M%3BNunnari%2C+J%3BHinshaw%2C+J+E&rft.aulast=Mears&rft.aufirst=J&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Truncated Leishmania K39 Kinesin Protein Binds Along Cortical Microtubules in an ATP-Dependant Manner and Accumulates at the Tip of the Cell T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39722001; 4034276 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Gerald, N J AU - Dwyer, D M Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Microtubules KW - Kinesin KW - Leishmania KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39722001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=A+Truncated+Leishmania+K39+Kinesin+Protein+Binds+Along+Cortical+Microtubules+in+an+ATP-Dependant+Manner+and+Accumulates+at+the+Tip+of+the+Cell&rft.au=Gerald%2C+N+J%3BDwyer%2C+D+M&rft.aulast=Gerald&rft.aufirst=N&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Probing Arf Guanine Nucleotide Exchange Factor (GEF) Specificity with Chimeric Proteins T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39718071; 4033262 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Cohen, L A AU - Donaldson, J G Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Nucleotides KW - Specificity KW - Guanine nucleotide exchange factor KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39718071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Probing+Arf+Guanine+Nucleotide+Exchange+Factor+%28GEF%29+Specificity+with+Chimeric+Proteins&rft.au=Cohen%2C+L+A%3BDonaldson%2C+J+G&rft.aulast=Cohen&rft.aufirst=L&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Calcium Signaling Protein Complexes in Oligodendrocyte Precursor (OP Cell) Membranes Isolated from Rat Cortices T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39715200; 4034154 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Weerth, S H AU - Hauser, J AU - Russell, J T Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Oligodendrocytes KW - Calcium signalling KW - Cell membranes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39715200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Calcium+Signaling+Protein+Complexes+in+Oligodendrocyte+Precursor+%28OP+Cell%29+Membranes+Isolated+from+Rat+Cortices&rft.au=Weerth%2C+S+H%3BHauser%2C+J%3BRussell%2C+J+T&rft.aulast=Weerth&rft.aufirst=S&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nitric Oxide Activates Peroxisome Proliferator-Activated Receptor Gamma through a p38 MAPK Signaling Pathway T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39712448; 4034577 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Ptasinska, A AU - Wang, S AU - Zhang, J AU - Danner, R L Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Peroxisome proliferator-activated receptors KW - MAP kinase KW - Signal transduction KW - Nitric oxide KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39712448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Nitric+Oxide+Activates+Peroxisome+Proliferator-Activated+Receptor+Gamma+through+a+p38+MAPK+Signaling+Pathway&rft.au=Ptasinska%2C+A%3BWang%2C+S%3BZhang%2C+J%3BDanner%2C+R+L&rft.aulast=Ptasinska&rft.aufirst=A&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rab11a is Required for Canalicular Biogenesis in WIF-B9 Hepatic Cells T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39712379; 4034557 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Wakabayashi, Y AU - Dutt, P AU - Lippincott-Schwartz, J AU - Arias, I M Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Biogenesis KW - Liver KW - Evolution KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39712379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Rab11a+is+Required+for+Canalicular+Biogenesis+in+WIF-B9+Hepatic+Cells&rft.au=Wakabayashi%2C+Y%3BDutt%2C+P%3BLippincott-Schwartz%2C+J%3BArias%2C+I+M&rft.aulast=Wakabayashi&rft.aufirst=Y&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Racial/Ethnic Variation in Colorectal Cancer Diagnosis: Should Screening Guidelines Consider Race/Ethnicity? T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39711388; 4085000 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Shavers, Vickie L Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Ethnic groups KW - Colorectal cancer KW - Races KW - Screening KW - Subpopulations KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39711388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Racial%2FEthnic+Variation+in+Colorectal+Cancer+Diagnosis%3A+Should+Screening+Guidelines+Consider+Race%2FEthnicity%3F&rft.au=Shavers%2C+Vickie+L&rft.aulast=Shavers&rft.aufirst=Vickie&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Metabolism of Tasidotin (ILX-651) by Cancer Cells: Mechanisms of Activation and Resistance T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39710995; 4033936 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Bai, R AU - Edler, M C AU - Copeland, T D AU - Schmid, S AU - Arthaud, L E AU - Hamel, E Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Metabolism KW - Cancer KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39710995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Chemistry&rft.atitle=High-Resolution+Serum+Proteomic+Profiling+of+Alzheimer+Disease+Samples+Reveals+Disease-Specific%2C+Carrier-Protein-Bound+Mass+Signatures&rft.au=Lopez%2C+Mary+F%3BMikulskis%2C+Alvydas%3BKuzdzal%2C+Scott%3BBennett%2C+David+A%3BKelly%2C+Jeremiah%3BGolenko%2C+Eva%3BDiCesare%2C+Joseph%3BDenoyer%2C+Eric%3BPatton%2C+Wayne+F%3BEdiger%2C+Richard%3BSapp%2C+Lisa%3BZiegert%2C+Tillmann%3BLynch%2C+Christopher%3BKramer%2C+Susan%3BWhiteley%2C+Gordon+R%3BWall%2C+Michael+R%3BMannion%2C+David+P%3Bdella+Cioppa%2C+Guy%3BRakitan%2C+John+S%3BWolfe%2C+Gershon+M&rft.aulast=Lopez&rft.aufirst=Mary&rft.date=2005-10-01&rft.volume=51&rft.issue=10&rft.spage=1946&rft.isbn=&rft.btitle=&rft.title=Clinical+Chemistry&rft.issn=00099147&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gonadotropin Receptor-Mediated Activation of G Protein-Activated Inwardly Rectifying K@@u+@ (GIRK) Channels in Hypothalamic GnRH Neurons. T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39710919; 4033515 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Hu, L. AU - Krsmanovic, L Z AU - Catt, K J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Potassium channels (inwardly-rectifying) KW - Pituitary (anterior) KW - Potassium KW - Channels KW - Neurons KW - Hypothalamus KW - Gonadotropin-releasing hormone KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39710919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Gonadotropin+Receptor-Mediated+Activation+of+G+Protein-Activated+Inwardly+Rectifying+K%40%40u%2B%40+%28GIRK%29+Channels+in+Hypothalamic+GnRH+Neurons.&rft.au=Hu%2C+L.%3BKrsmanovic%2C+L+Z%3BCatt%2C+K+J&rft.aulast=Hu&rft.aufirst=L.&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The szy-20 (bs52) Mutation is a Suppressor of zyg-1 and Defines a Novel Regulator of the Cell Cycle T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39710413; 4033389 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Song, M Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Mutation KW - Suppressors KW - Cell cycle KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39710413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+szy-20+%28bs52%29+Mutation+is+a+Suppressor+of+zyg-1+and+Defines+a+Novel+Regulator+of+the+Cell+Cycle&rft.au=Song%2C+M&rft.aulast=Song&rft.aufirst=M&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Cyclin Dependent Kinase 5 Activator p39 Binds Myosin Essential Light Chain T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39708509; 4032764 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Tripathi, B K AU - Ledee, D R AU - Zelenka, P S Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Myosin KW - Light chains KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39708509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Cyclin+Dependent+Kinase+5+Activator+p39+Binds+Myosin+Essential+Light+Chain&rft.au=Tripathi%2C+B+K%3BLedee%2C+D+R%3BZelenka%2C+P+S&rft.aulast=Tripathi&rft.aufirst=B&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Increased Expression of the Inserted Myosin II-C Isoform in Tumor Cell Lines T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39708424; 4032760 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Jana, S S AU - Adelstein, R S Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Myosin KW - Tumor cell lines KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39708424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Increased+Expression+of+the+Inserted+Myosin+II-C+Isoform+in+Tumor+Cell+Lines&rft.au=Jana%2C+S+S%3BAdelstein%2C+R+S&rft.aulast=Jana&rft.aufirst=S&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intracellular Dynamics of Drosophila Myosin-V T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39705120; 4032686 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Toth, J AU - Sellers, J R Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Drosophila KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39705120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Intracellular+Dynamics+of+Drosophila+Myosin-V&rft.au=Toth%2C+J%3BSellers%2C+J+R&rft.aulast=Toth&rft.aufirst=J&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tobacco and Alcohol Use Among Homosexual and Bisexual Adults in California T2 - 133rd Annual Meeting and Exposition of the American Public Health Association AN - 39705017; 4085420 JF - 133rd Annual Meeting and Exposition of the American Public Health Association AU - Grauman, Alyssa R AU - Lawrence, Deirdre M AU - Allen, Nathaniel AU - Davis, William Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - USA, California KW - Alcohols KW - Homosexuality KW - Tobacco KW - Bisexual KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39705017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Tobacco+and+Alcohol+Use+Among+Homosexual+and+Bisexual+Adults+in+California&rft.au=Grauman%2C+Alyssa+R%3BLawrence%2C+Deirdre+M%3BAllen%2C+Nathaniel%3BDavis%2C+William&rft.aulast=Grauman&rft.aufirst=Alyssa&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=133rd+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/133am/techprogram/meeting.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Monitoring the ER Luminal and the Cytosolic Face of the ERAD Substrate CD3delta T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39695995; 4033288 DE: JF - 45th Annual Meeting of the American Society for Cell Biology AU - Lorenz, H AU - Lippincott-Schwartz, J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39695995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Monitoring+the+ER+Luminal+and+the+Cytosolic+Face+of+the+ERAD+Substrate+CD3delta&rft.au=Lorenz%2C+H%3BLippincott-Schwartz%2C+J&rft.aulast=Lorenz&rft.aufirst=H&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Avian Malaria Parasite Plasmodium gallinaceum Modifies the Surface Topography of Infected Erythrocytes T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39693376; 4033580 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Arie, T AU - Dorward, D W AU - Dvorak, J A Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Parasites KW - Malaria KW - Erythrocytes KW - Topography KW - Surface topography KW - Plasmodium gallinaceum KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39693376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Avian+Malaria+Parasite+Plasmodium+gallinaceum+Modifies+the+Surface+Topography+of+Infected+Erythrocytes&rft.au=Arie%2C+T%3BDorward%2C+D+W%3BDvorak%2C+J+A&rft.aulast=Arie&rft.aufirst=T&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Src-kinase Expression Inhibits Compensatory Endocytosis During Early Sea Urchin Development T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39689323; 4033263 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Covian-Nares, J F AU - Vogel, S S Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Endocytosis KW - Echinoidea KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39689323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Src-kinase+Expression+Inhibits+Compensatory+Endocytosis+During+Early+Sea+Urchin+Development&rft.au=Covian-Nares%2C+J+F%3BVogel%2C+S+S&rft.aulast=Covian-Nares&rft.aufirst=J&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Folding of Nascent SecM within the Ribosome Exit Tunnel is Required for Translation Arrest T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39688961; 4033166 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Woolhead, C A AU - Johnson, A E AU - Bernstein, H D Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Translation KW - Tunnels KW - Ribosomes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39688961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Folding+of+Nascent+SecM+within+the+Ribosome+Exit+Tunnel+is+Required+for+Translation+Arrest&rft.au=Woolhead%2C+C+A%3BJohnson%2C+A+E%3BBernstein%2C+H+D&rft.aulast=Woolhead&rft.aufirst=C&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Rap-GEF/Rap GTPase Signaling Controls Stem Cell Niche Formation through Regulating Adherens Junctions in the Drosophila Testis T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39687447; 4034851 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Hou, S X AU - Wang, H AU - Singh, S AU - Zheng, Z AU - Oh, S. AU - Chen, X Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Adherens junctions KW - Stem cells KW - Guanosinetriphosphatase KW - Signal transduction KW - Niches KW - Testes KW - Drosophila KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39687447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=A+Rap-GEF%2FRap+GTPase+Signaling+Controls+Stem+Cell+Niche+Formation+through+Regulating+Adherens+Junctions+in+the+Drosophila+Testis&rft.au=Hou%2C+S+X%3BWang%2C+H%3BSingh%2C+S%3BZheng%2C+Z%3BOh%2C+S.%3BChen%2C+X&rft.aulast=Hou&rft.aufirst=S&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phosphatases and Kinases Regulate AP2 Binding and Release from Plasma Membrane T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39683854; 4034995 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Yim, Y AU - Scarselletta, S AU - Eisenberg, E AU - Greene, L E Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Plasma membranes KW - Phosphatase KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39683854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Phosphatases+and+Kinases+Regulate+AP2+Binding+and+Release+from+Plasma+Membrane&rft.au=Yim%2C+Y%3BScarselletta%2C+S%3BEisenberg%2C+E%3BGreene%2C+L+E&rft.aulast=Yim&rft.aufirst=Y&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Syntabulin-Mediated Anterograde Transport of Mitochondria Along Neuronal Processes T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39682783; 4033541 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Cai, Q AU - Sheng, Z Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Anterograde transport KW - Mitochondria KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39682783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Caplan%2C+Bryan&rft.aulast=Caplan&rft.aufirst=Bryan&rft.date=2007-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=0-691-12942-8&rft.btitle=The+myth+of+the+rational+voter%3A+Why+democracies+choose+bad+policies&rft.title=The+myth+of+the+rational+voter%3A+Why+democracies+choose+bad+policies&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Mammary Stem Cell Niche Modulates the Repertoire of Testicular Stem Cells T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39681415; 4034854 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Boulanger, C A AU - Mack, D L AU - Booth, B W AU - Smith, G H Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Stem cells KW - Niches KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39681415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Mammary+Stem+Cell+Niche+Modulates+the+Repertoire+of+Testicular+Stem+Cells&rft.au=Boulanger%2C+C+A%3BMack%2C+D+L%3BBooth%2C+B+W%3BSmith%2C+G+H&rft.aulast=Boulanger&rft.aufirst=C&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The SPG3A Hereditary Spastic Paraplegia Protein Atlastin-1 is Enriched in Axonal Growth Cones T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39680851; 4034742 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Zhu, P AU - Tao-Cheng, S J H AU - Smith, C L AU - Stadler, J AU - Yang, S M AU - Blackstone, C Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Growth cones KW - Spastic paraplegia KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39680851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+SPG3A+Hereditary+Spastic+Paraplegia+Protein+Atlastin-1+is+Enriched+in+Axonal+Growth+Cones&rft.au=Zhu%2C+P%3BTao-Cheng%2C+S+J+H%3BSmith%2C+C+L%3BStadler%2C+J%3BYang%2C+S+M%3BBlackstone%2C+C&rft.aulast=Zhu&rft.aufirst=P&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Displacement of the Bromodomain Protein Brd4 from Chromosomes is Required for the Recovery from Anti-Microtubule Drug Induced Mitotic Arrest T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39680360; 4035054 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Nishiyama, A AU - Ozato, K Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Drugs KW - Chromosomes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39680360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Displacement+of+the+Bromodomain+Protein+Brd4+from+Chromosomes+is+Required+for+the+Recovery+from+Anti-Microtubule+Drug+Induced+Mitotic+Arrest&rft.au=Nishiyama%2C+A%3BOzato%2C+K&rft.aulast=Nishiyama&rft.aufirst=A&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Drosophila Myosin V T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39679090; 4034615 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Hong, A AU - Toth, J AU - Sellers, J R Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Myosin KW - Drosophila KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39679090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Drosophila+Myosin+V&rft.au=Hong%2C+A%3BToth%2C+J%3BSellers%2C+J+R&rft.aulast=Hong&rft.aufirst=A&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Agrin-induced Formation of Filopodia Depends on GAG Chains and Cdc42 T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39678178; 4034396 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Lin, L AU - McCroskery, S AU - Ross, J M AU - Daniels, M P Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Pseudopodia KW - Cdc42 protein KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39678178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Agrin-induced+Formation+of+Filopodia+Depends+on+GAG+Chains+and+Cdc42&rft.au=Lin%2C+L%3BMcCroskery%2C+S%3BRoss%2C+J+M%3BDaniels%2C+M+P&rft.aulast=Lin&rft.aufirst=L&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Over Expression of Human ClpP Reduces AIF Levels and Inhibits Cisplatin-Induced Apoptosis in Huh4 Cells. T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39674273; 4032496 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Zhang, Y AU - Barr, V AU - Maurizi1, M. R. Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Apoptosis-inducing factor KW - Apoptosis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39674273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Over+Expression+of+Human+ClpP+Reduces+AIF+Levels+and+Inhibits+Cisplatin-Induced+Apoptosis+in+Huh4+Cells.&rft.au=Zhang%2C+Y%3BBarr%2C+V%3BMaurizi1%2C+M.+R.&rft.aulast=Zhang&rft.aufirst=Y&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activated AKT Regulates Nf-?B Activation, P53 Inhibition and Cell Survival in HTLV-1-transformed Cells T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39674142; 4032454 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Jeong, S AU - Pise-Masison, C A AU - Radonovich, M F AU - Park, H AU - Brady, J N Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - AKT protein KW - Cell survival KW - P53 protein KW - Human T-lymphotropic virus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39674142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Activated+AKT+Regulates+Nf-%3FB+Activation%2C+P53+Inhibition+and+Cell+Survival+in+HTLV-1-transformed+Cells&rft.au=Jeong%2C+S%3BPise-Masison%2C+C+A%3BRadonovich%2C+M+F%3BPark%2C+H%3BBrady%2C+J+N&rft.aulast=Jeong&rft.aufirst=S&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Actin Rockets Guide Membrane Protrusion and Position Primed Integrins to Direct Pathfinding T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39673028; 4032846 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Galbraith, C G AU - Yamada, K M AU - Galbraith, J A Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Membranes KW - Integrins KW - Actin KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39673028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Actin+Rockets+Guide+Membrane+Protrusion+and+Position+Primed+Integrins+to+Direct+Pathfinding&rft.au=Galbraith%2C+C+G%3BYamada%2C+K+M%3BGalbraith%2C+J+A&rft.aulast=Galbraith&rft.aufirst=C&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dissecting the Role of Rho-Mediated Signaling in Contractile Ring Formation T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39668551; 4032541 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Kamijo, K AU - Ohara, N AU - Abe, M AU - Uchimura, T AU - Hosoya, H AU - Lee, J AU - Miki, T Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Signal transduction KW - Contractility KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39668551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Dissecting+the+Role+of+Rho-Mediated+Signaling+in+Contractile+Ring+Formation&rft.au=Kamijo%2C+K%3BOhara%2C+N%3BAbe%2C+M%3BUchimura%2C+T%3BHosoya%2C+H%3BLee%2C+J%3BMiki%2C+T&rft.aulast=Kamijo&rft.aufirst=K&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Peroxisomal Membrane Protein, Pex16p, is Involved in the Formation Peroxisomes at the Endoplasmic Reticulum T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39637007; 4033186 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Kim, P K AU - Mullen, R T AU - Lippincott-Schwartz, J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Peroxisomal membrane protein KW - Peroxisomes KW - Endoplasmic reticulum KW - Membranes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39637007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Peroxisomal+Membrane+Protein%2C+Pex16p%2C+is+Involved+in+the+Formation+Peroxisomes+at+the+Endoplasmic+Reticulum&rft.au=Kim%2C+P+K%3BMullen%2C+R+T%3BLippincott-Schwartz%2C+J&rft.aulast=Kim&rft.aufirst=P&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Transmembrane Domain of the PC3: A Key Motif for Targeting to the Regulated Secretory Pathway T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39636956; 4033177 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Lou, H AU - Smith, A M AU - Coates, L C AU - Birch, N P AU - Loh, Y P Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Transmembrane domains KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39636956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Transmembrane+Domain+of+the+PC3%3A+A+Key+Motif+for+Targeting+to+the+Regulated+Secretory+Pathway&rft.au=Lou%2C+H%3BSmith%2C+A+M%3BCoates%2C+L+C%3BBirch%2C+N+P%3BLoh%2C+Y+P&rft.aulast=Lou&rft.aufirst=H&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bcl-XL Enhances the Effect of GM-CSF in the in Vitro Development of the Monocyte/Macrophage Lineage T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39636385; 4033406 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Antignani, A AU - Youle, R J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Granulocyte-macrophage colony-stimulating factor KW - Macrophages KW - Bcl-x protein KW - Monocytes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39636385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Bcl-XL+Enhances+the+Effect+of+GM-CSF+in+the+in+Vitro+Development+of+the+Monocyte%2FMacrophage+Lineage&rft.au=Antignani%2C+A%3BYoule%2C+R+J&rft.aulast=Antignani&rft.aufirst=A&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activities of Dolastatin 15 Peptide Analogs as Inhibitors of Tubulin Assembly and Vinblastine Binding T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39634706; 4032769 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Edler, M C AU - Bai, R AU - Hamel, E Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Vinblastine KW - Peptides KW - Analogs KW - Inhibitors KW - Tubulin KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39634706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Activities+of+Dolastatin+15+Peptide+Analogs+as+Inhibitors+of+Tubulin+Assembly+and+Vinblastine+Binding&rft.au=Edler%2C+M+C%3BBai%2C+R%3BHamel%2C+E&rft.aulast=Edler&rft.aufirst=M&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of Macroautophagy by Proteasome Inhibition in Living Cells T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39633683; 4034675 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Hailey, D W AU - Whiteman, E L AU - Lorenz, H AU - Lippincott-Schwartz, J Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Proteasomes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39633683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Induction+of+Macroautophagy+by+Proteasome+Inhibition+in+Living+Cells&rft.au=Hailey%2C+D+W%3BWhiteman%2C+E+L%3BLorenz%2C+H%3BLippincott-Schwartz%2C+J&rft.aulast=Hailey&rft.aufirst=D&rft.date=2005-12-10&rft.volume=14&rft.issue=4&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nonverbal+Behavior&rft.issn=01915886&rft_id=info:doi/10.1007%2FBF00989320 L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Sulfation Pattern of Chondroitin Regulates Axonal Guidance T2 - 45th Annual Meeting of the American Society for Cell Biology AN - 39632645; 4034877 JF - 45th Annual Meeting of the American Society for Cell Biology AU - Katagiri, Y AU - Wang, H AU - Geller, H M Y1 - 2005/12/10/ PY - 2005 DA - 2005 Dec 10 KW - Axon guidance KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39632645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Differential+Sulfation+Pattern+of+Chondroitin+Regulates+Axonal+Guidance&rft.au=Katagiri%2C+Y%3BWang%2C+H%3BGeller%2C+H+M&rft.aulast=Katagiri&rft.aufirst=Y&rft.date=2005-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/am2005/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Neuroscience. Synaptic membranes bend to the will of a neurotoxin. AN - 68892494; 16339436 JF - Science (New York, N.Y.) AU - Zimmerberg, Joshua AU - Chernomordik, Leonid V AD - Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1855, USA. joshz@helix.nih.gov Y1 - 2005/12/09/ PY - 2005 DA - 2005 Dec 09 SP - 1626 EP - 1627 VL - 310 IS - 5754 KW - Fatty Acids KW - 0 KW - Lipid Bilayers KW - Lysophospholipids KW - Membrane Lipids KW - Micelles KW - Neurotoxins KW - Neurotransmitter Agents KW - Phospholipases A KW - EC 3.1.1.32 KW - Index Medicus KW - Animals KW - Neurotoxins -- metabolism KW - Membrane Lipids -- metabolism KW - Exocytosis KW - Mice KW - Neuromuscular Junction -- physiology KW - Neurotoxins -- toxicity KW - Hydrolysis KW - Neuromuscular Junction -- drug effects KW - Neurotransmitter Agents -- metabolism KW - Membrane Lipids -- analysis KW - Membrane Fusion KW - Synaptic Vesicles -- physiology KW - Phospholipases A -- toxicity KW - Synaptic Membranes -- chemistry KW - Lysophospholipids -- metabolism KW - Synaptic Membranes -- physiology KW - Phospholipases A -- metabolism KW - Fatty Acids -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68892494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28New+York%2C+N.Y.%29&rft.atitle=Neuroscience.+Synaptic+membranes+bend+to+the+will+of+a+neurotoxin.&rft.au=Zimmerberg%2C+Joshua%3BChernomordik%2C+Leonid+V&rft.aulast=Zimmerberg&rft.aufirst=Joshua&rft.date=2005-12-09&rft.volume=310&rft.issue=5754&rft.spage=1626&rft.isbn=&rft.btitle=&rft.title=Science+%28New+York%2C+N.Y.%29&rft.issn=1095-9203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-19 N1 - Date created - 2005-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Science. 2005 Dec 9;310(5754):1678-80 [16339444] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Multifunctional roles of the conserved Arg residues in the second region of homology of p97/valosin-containing protein. AN - 68859656; 16216872 AB - The 97-kDa molecular chaperone valosin-containing protein (VCP) belongs to a highly conserved AAA family and forms a hexameric structure that is essential for its biological functions. The AAA domain contains highly conserved motifs, the Walker A, Walker B, and the second region of homology (SRH). Although Walker A and B motifs mediate ATP binding and hydrolysis, respectively, the function of the SRH in VCP is not clear. We examined the significance of the SRH in VCP, especially the conserved Arg(359) and Arg(362) in the first AAA domain, D1 and Arg(635) and Arg(638) in the second AAA domain, D2. We show that Arg(359) and Arg(362) in D1 are critical for maintaining the hexameric structure and the ability to bind the polyubiquitin chains. Although the rest of the tested SRH mutants retain the hexameric structure, all of them exhibit severely reduced ATPase activity. Tryptophan fluorescence analysis showed that all of the tested mutants can bind to ATP or ADP. Thus, the reduced ATPase activity likely results from the hampered communications among protomers during hydrolysis. Moreover, when the ATPase-defective mutant R635A or R638A is mixed with the Walker A mutant of D2, the ATPase activity is partially restored, suggesting that Arg(635) and Arg(638) can stimulate the ATPase activity of the neighboring protomer. Interestingly, mutation of Arg(359) and Arg(362) uncouples the inhibitory effect of p47, a VCP co-factor, on the ATPase activity of VCP. Therefore, the Arg residues allow D1 to take on a specific conformation that is required for substrate binding and co-factor communications. Taken together, these results demonstrate that the conserved Arg residues in the SRH of both D1 and D2 play critical roles in communicating the conformational changes required for ATP hydrolysis, and SRH in D1 also contributes to substrate binding and co-factor communications. JF - The Journal of biological chemistry AU - Wang, Qing AU - Song, Changcheng AU - Irizarry, Lauren AU - Dai, Renming AU - Zhang, Xiaodong AU - Li, Chou-Chi H AD - Laboratory of Cancer Prevention, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA. qwang@ncifcrf.gov Y1 - 2005/12/09/ PY - 2005 DA - 2005 Dec 09 SP - 40515 EP - 40523 VL - 280 IS - 49 SN - 0021-9258, 0021-9258 KW - Cell Cycle Proteins KW - 0 KW - Recombinant Fusion Proteins KW - Polyubiquitin KW - 120904-94-1 KW - Tryptophan KW - 8DUH1N11BX KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Arginine KW - 94ZLA3W45F KW - Adenosine Triphosphatases KW - EC 3.6.1.- KW - CDC48 protein KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Polyubiquitin -- metabolism KW - Spectrometry, Fluorescence KW - Adenosine Triphosphate -- metabolism KW - Molecular Sequence Data KW - Adenosine Triphosphatases -- metabolism KW - Amino Acid Sequence KW - Tryptophan -- chemistry KW - Hydrolysis KW - Adenosine Triphosphatases -- genetics KW - Structure-Activity Relationship KW - Protein Conformation KW - Cell Cycle Proteins -- physiology KW - Cell Cycle Proteins -- chemistry KW - Conserved Sequence KW - Cell Cycle Proteins -- genetics KW - Arginine -- genetics KW - Arginine -- chemistry KW - Arginine -- physiology KW - Sequence Homology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68859656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Multifunctional+roles+of+the+conserved+Arg+residues+in+the+second+region+of+homology+of+p97%2Fvalosin-containing+protein.&rft.au=Wang%2C+Qing%3BSong%2C+Changcheng%3BIrizarry%2C+Lauren%3BDai%2C+Renming%3BZhang%2C+Xiaodong%3BLi%2C+Chou-Chi+H&rft.aulast=Wang&rft.aufirst=Qing&rft.date=2005-12-09&rft.volume=280&rft.issue=49&rft.spage=40515&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-06 N1 - Date created - 2005-12-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Induction of apoptosis in human leukemia cells by black tea and its polyphenol theaflavin. AN - 68734903; 16253767 AB - Treatment of human leukemic cell lines HL-60 and K-562 with extracts of green and black tea and their polyphenols epigallocatechin gallate and theaflavins, respectively, showed a dose dependent inhibition of growth as a result of cytotoxicity and suppression of cell proliferation. Based on the IC50 values obtained from cytotoxicity data it was clearly evident that black tea was as efficient as green tea. Analysis of polyphenol contents of tea extracts revealed that not only epigallocatechin gallate, which is a predominant polyphenol of green tea, but also theaflavin that is abundantly present in black tea affords significant chemotherapeutic action by imparting cytotoxicity to human leukemic cells. Electrophoretic analysis of fragmented DNA from treated cells displayed characteristic ladder pattern. Flow cytometric analysis revealed the dose dependent increase in sub-G1 peak. These criteria confirmed that cytotoxic activity of green and black tea was due to induction of apoptosis. Such induction was found to be mediated through activation of caspases 3 and 8, particularly caspase 3 and by altering apoptosis related genes as evident by down-regulation of Bcl-2 and up-regulation of Bax proteins. JF - Cancer letters AU - Kundu, Trina AU - Dey, Subhabrata AU - Roy, Madhumita AU - Siddiqi, M AU - Bhattacharya, R K AD - Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, 37 S.P. Mukherjee Road, Kolkata 700 026, India. Y1 - 2005/12/08/ PY - 2005 DA - 2005 Dec 08 SP - 111 EP - 121 VL - 230 IS - 1 SN - 0304-3835, 0304-3835 KW - Antioxidants KW - 0 KW - Biflavonoids KW - Flavonoids KW - Phenols KW - Polyphenols KW - Tea KW - bcl-2-Associated X Protein KW - theaflavin KW - 1IA46M0D13 KW - Catechin KW - 8R1V1STN48 KW - CASP3 protein, human KW - EC 3.4.22.- KW - CASP8 protein, human KW - Caspase 3 KW - Caspase 8 KW - Caspases KW - Index Medicus KW - Phenols -- pharmacology KW - HL-60 Cells KW - Humans KW - Caspases -- metabolism KW - Phenols -- analysis KW - Flavonoids -- analysis KW - Genes, bcl-2 KW - Down-Regulation KW - Flow Cytometry KW - Caspases -- drug effects KW - Flavonoids -- pharmacology KW - Antioxidants -- pharmacology KW - Apoptosis -- drug effects KW - Biflavonoids -- pharmacology KW - Tea -- chemistry KW - Catechin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68734903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Induction+of+apoptosis+in+human+leukemia+cells+by+black+tea+and+its+polyphenol+theaflavin.&rft.au=Kundu%2C+Trina%3BDey%2C+Subhabrata%3BRoy%2C+Madhumita%3BSiddiqi%2C+M%3BBhattacharya%2C+R+K&rft.aulast=Kundu&rft.aufirst=Trina&rft.date=2005-12-08&rft.volume=230&rft.issue=1&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-23 N1 - Date created - 2005-10-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Diphenylmethyl selenocyanate inhibits DMBA-croton oil induced two-stage mouse skin carcinogenesis by inducing apoptosis and inhibiting cutaneous cell proliferation. AN - 68733085; 16253765 AB - Numerous epidemiological and experimental studies have showed the inverse relationship between dietary selenium intake and different types of cancer. Continuous efforts are going on to develop suitable organoselenium compounds, which can be used as cancer chemopreventive agents for human. In the present study, a synthetic organoselenium compound diphenylmethyl selenocyanate was evaluated for its ability to arrest cell proliferation and to induce apoptosis against 7,12-dimethylbenz[a]anthracene-croton oil induced two-stage mouse skin carcinogenesis model. Reduction in the incidence and number of papilloma, the preneoplastic lesion, was considered to be the mean of assessment. Significant decrease in the level of cell proliferation (p<0.01) and significant enhancement in the level of apoptosis (p<0.01) were found. Caspase-3, which contribute a part in the process of cellular apoptosis to prevent further cellular differentiation was also elevated significantly (P<0.01) during the treatment with the Se compound. These observations seem to be correlated with the significant reduction in the corresponding number of skin papilloma formation after 12 weeks of experiment. Thus the compound, diphenylmethyl selenocyanate may be considered for further research to establish it as an effective cancer chemopreventive agent. JF - Cancer letters AU - Das, Rajat Kumar AU - Hossain, S K Ugir AU - Bhattacharya, Sudin AD - Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700 026, India. Y1 - 2005/12/08/ PY - 2005 DA - 2005 Dec 08 SP - 90 EP - 101 VL - 230 IS - 1 SN - 0304-3835, 0304-3835 KW - Carcinogens KW - 0 KW - Dermatologic Agents KW - Organoselenium Compounds KW - diphenylmethyl selenocyanate KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Croton Oil KW - 8001-28-3 KW - CASP3 protein, human KW - EC 3.4.22.- KW - Casp3 protein, mouse KW - Caspase 3 KW - Caspases KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Animals KW - Caspases -- analysis KW - Apoptosis -- drug effects KW - Caspases -- biosynthesis KW - Mice KW - Chemoprevention KW - Female KW - Skin Neoplasms -- physiopathology KW - Organoselenium Compounds -- pharmacology KW - Croton Oil -- toxicity KW - Papilloma -- prevention & control KW - 9,10-Dimethyl-1,2-benzanthracene -- toxicity KW - Skin Neoplasms -- chemically induced KW - Carcinogens -- toxicity KW - Papilloma -- physiopathology KW - Skin Neoplasms -- prevention & control KW - Papilloma -- chemically induced KW - Dermatologic Agents -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68733085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Diphenylmethyl+selenocyanate+inhibits+DMBA-croton+oil+induced+two-stage+mouse+skin+carcinogenesis+by+inducing+apoptosis+and+inhibiting+cutaneous+cell+proliferation.&rft.au=Das%2C+Rajat+Kumar%3BHossain%2C+S+K+Ugir%3BBhattacharya%2C+Sudin&rft.aulast=Das&rft.aufirst=Rajat&rft.date=2005-12-08&rft.volume=230&rft.issue=1&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-23 N1 - Date created - 2005-10-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adjuvant chemotherapy for stage III colon cancer: implications of race/ethnicity, age, and differentiation. AN - 68879390; 16333005 AB - A 1990 National Institutes of Health Consensus Conference recommended that patients with stage III colon cancer receive adjuvant chemotherapy because survival was improved in clinical trials in patients who received a 5-fluorouracil-based regimen. To determine whether adjuvant chemotherapy is used in the community as a standard of practice that improves outcome and whether it failed to benefit any specific sets of patients. Prospective data from 85 934 patients with stage III colon cancer from 560 hospital cancer registries were entered into the National Cancer Data Base between 1990 and 2002 and included standard clinical, pathological, and first course of treatment variables. Prevalence of adjuvant chemotherapy usage and 5-year survival in patients treated in US hospitals. Adjuvant chemotherapy use increased from 39% in 1991 to 64% in 2002 but was lower in black, female, and elderly patients. It improved 5-year survival from almost 8% in 1991 to more than 16% in 1997 compared with surgery alone. Adjuvant chemotherapy increases survival in elderly patients as much as it does in younger patients. However, the benefit of adjuvant chemotherapy in blacks and those with high-grade cancers is not as great. Adjuvant chemotherapy use has increased from 1990 to 2002 for patients with stage III colon cancer with an associated increase in 5-year survival of 16%. The benefit of adjuvant chemotherapy seems to be lower in black patients and high-grade cancers. Women have the same benefit but are less often treated. Elderly patients have the same benefit as younger patients but are less frequently treated. New options for adjuvant therapy in 2004-2005 may further improve the outcome of patients with stage III colon cancer. JF - JAMA AU - Jessup, J Milburn AU - Stewart, Andrew AU - Greene, Frederick L AU - Minsky, Bruce D AD - Department of Oncology, Georgetown University Medical Center, Washington, DC, USA. jessupj@mail.nih.gov Y1 - 2005/12/07/ PY - 2005 DA - 2005 Dec 07 SP - 2703 EP - 2711 VL - 294 IS - 21 KW - Adjuvants, Immunologic KW - 0 KW - Antimetabolites, Antineoplastic KW - Levamisole KW - 2880D3468G KW - Fluorouracil KW - U3P01618RT KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Age Factors KW - Sex Factors KW - Neoplasm Staging KW - Humans KW - Prognosis KW - Aged KW - European Continental Ancestry Group -- statistics & numerical data KW - African Continental Ancestry Group -- statistics & numerical data KW - Drug Utilization KW - Fluorouracil -- therapeutic use KW - Aged, 80 and over KW - Middle Aged KW - Antimetabolites, Antineoplastic -- therapeutic use KW - Male KW - Adjuvants, Immunologic -- therapeutic use KW - Female KW - Survival Analysis KW - Proportional Hazards Models KW - Levamisole -- therapeutic use KW - Chemotherapy, Adjuvant -- utilization KW - Colonic Neoplasms -- mortality KW - Colonic Neoplasms -- drug therapy KW - Colonic Neoplasms -- ethnology KW - Colonic Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68879390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Adjuvant+chemotherapy+for+stage+III+colon+cancer%3A+implications+of+race%2Fethnicity%2C+age%2C+and+differentiation.&rft.au=Jessup%2C+J+Milburn%3BStewart%2C+Andrew%3BGreene%2C+Frederick+L%3BMinsky%2C+Bruce+D&rft.aulast=Jessup&rft.aufirst=J&rft.date=2005-12-07&rft.volume=294&rft.issue=21&rft.spage=2703&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=1538-3598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-09 N1 - Date created - 2005-12-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: JAMA. 2005 Dec 7;294(21):2758-60 [16333012] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toll-like receptor 4 in butylated hydroxytoluene-induced mouse pulmonary inflammation and tumorigenesis. AN - 68874081; 16333033 AB - Because chronic pulmonary diseases predispose to lung neoplasia, the identification of the molecular mechanisms involved could provide novel preventive, diagnostic, and therapeutic strategies. Toll-like receptors (TLRs) transduce exogenous and endogenous signals into the production of inflammatory cytokines to coordinate adaptive immune responses. To determine the role of Tlr4 in chronic lung inflammation, we compared lung permeability, leukocyte infiltration, and nuclear factor kappa B (NFkappaB) and activator protein 1 (AP-1) DNA binding in butylated hydroxytoluene (BHT)-treated (four weekly injections of 125-200 mg/kg each) inbred mouse strains with functional Tlr4 (OuJ and BALB) and mutated Tlr4 (HeJ and BALB(Lps-d)). We also measured primary tumor formation in these mice after single-carcinogen injection (3-methylcholanthrene; 10 microg/kg), followed by BHT treatment (six weekly injections of 125-200 mg/kg each). Mice with functional Tlr4 had reduced lung permeability, leukocyte inflammation, and primary tumor formation (BALB(Lps-d), mean = 22.3 tumors/mouse, versus BALB, mean = 13.9 tumors/mouse, difference = 8.4 tumors/mouse, 95% confidence interval = 4.6 to 12.1 tumors/mouse; P = .025) compared with mice with mutated Tlr4. NFkappaB DNA binding activity was higher in OuJ than in HeJ mice; however, AP-1 activity was elevated in HeJ mice. To our knowledge, this is the first model to demonstrate a modulatory role for Tlr4 in chronic lung inflammation and tumorigenesis. JF - Journal of the National Cancer Institute AU - Bauer, Alison K AU - Dixon, Darlene AU - DeGraff, Laura M AU - Cho, Hye-Youn AU - Walker, Christopher R AU - Malkinson, Alvin M AU - Kleeberger, Steven R AD - Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. bauer1@niehs.nih.gov Y1 - 2005/12/07/ PY - 2005 DA - 2005 Dec 07 SP - 1778 EP - 1781 VL - 97 IS - 23 KW - NF-kappa B KW - 0 KW - Tlr4 protein, mouse KW - Toll-Like Receptor 4 KW - Transcription Factor AP-1 KW - Butylated Hydroxytoluene KW - 1P9D0Z171K KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Transcription Factor AP-1 -- metabolism KW - Disease Models, Animal KW - Mice KW - Mutation KW - NF-kappa B -- metabolism KW - Pneumonia -- chemically induced KW - Toll-Like Receptor 4 -- genetics KW - Toll-Like Receptor 4 -- metabolism KW - Lung Neoplasms -- chemically induced KW - Pneumonia -- metabolism KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68874081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Toll-like+receptor+4+in+butylated+hydroxytoluene-induced+mouse+pulmonary+inflammation+and+tumorigenesis.&rft.au=Bauer%2C+Alison+K%3BDixon%2C+Darlene%3BDeGraff%2C+Laura+M%3BCho%2C+Hye-Youn%3BWalker%2C+Christopher+R%3BMalkinson%2C+Alvin+M%3BKleeberger%2C+Steven+R&rft.aulast=Bauer&rft.aufirst=Alison&rft.date=2005-12-07&rft.volume=97&rft.issue=23&rft.spage=1778&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-15 N1 - Date created - 2005-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mutational analysis of the Arf1*GTP/Arf GAP interface reveals an Arf1 mutant that selectively affects the Arf GAP ASAP1. AN - 68876671; 16332543 AB - Arf1 is a GTP binding protein that functions at a number of cellular sites to control membrane traffic and actin remodeling. Arf1 is regulated by site-specific GTPase-activating proteins (GAPs). The combined results of crystallographic and biochemical studies have led to the proposal that Arf1 GAPs differ in the specific interface formed with Arf1. To test this hypothesis, we have used mutagenesis to examine the interaction of three Arf GAPs (ASAP1, AGAP1, and ArfGAP1) with switch 1, switch 2, and alpha helix3 of Arf1. The GAPs were similar in being affected by mutations in switch 1 and 2. However, effects of a mutation within alpha helix3 and specific mutations within switch 1 and 2 differed among the GAPs. The largest differences were observed with a change of isoleucine 46 to aspartate ([I46D]Arf1), which reduced ASAP1-induced catalysis by approximately 10,000-fold but had a 3-fold effect on AGAP1. The reduction was due to an isolated effect on the catalytic rate, k(cat). In vivo [I46D]Arf1 had no detectable effect on the Golgi apparatus but, instead, functioned as a constitutively active mutant in the cell periphery, affecting the localization of ASAP1 and paxillin. Based on our results, we conclude that the contribution of specific residues within switch 1 of Arf to binding and achieving a transition state toward GTP hydrolysis differs among Arf GAPs. JF - Current biology : CB AU - Luo, Ruibai AU - Jacques, Kerry AU - Ahvazi, Bijan AU - Stauffer, Stacey AU - Premont, Richard T AU - Randazzo, Paul A AD - Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2005/12/06/ PY - 2005 DA - 2005 Dec 06 SP - 2164 EP - 2169 VL - 15 IS - 23 SN - 0960-9822, 0960-9822 KW - AGAP1 protein, human KW - 0 KW - ASAP1 protein, human KW - Adaptor Proteins, Signal Transducing KW - GTPase-Activating Proteins KW - Guanosine Triphosphate KW - 86-01-1 KW - ADP-Ribosylation Factor 1 KW - EC 3.6.5.2 KW - ADP-Ribosylation Factors KW - Index Medicus KW - Animals KW - Humans KW - DNA Mutational Analysis KW - Mutation -- genetics KW - Mice KW - Golgi Apparatus -- metabolism KW - Fluorescent Antibody Technique KW - NIH 3T3 Cells KW - Guanosine Triphosphate -- metabolism KW - Catalysis KW - Adaptor Proteins, Signal Transducing -- metabolism KW - GTPase-Activating Proteins -- metabolism KW - Models, Molecular KW - ADP-Ribosylation Factors -- metabolism KW - ADP-Ribosylation Factor 1 -- metabolism KW - ADP-Ribosylation Factor 1 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68876671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+biology+%3A+CB&rft.atitle=Mutational+analysis+of+the+Arf1*GTP%2FArf+GAP+interface+reveals+an+Arf1+mutant+that+selectively+affects+the+Arf+GAP+ASAP1.&rft.au=Luo%2C+Ruibai%3BJacques%2C+Kerry%3BAhvazi%2C+Bijan%3BStauffer%2C+Stacey%3BPremont%2C+Richard+T%3BRandazzo%2C+Paul+A&rft.aulast=Luo&rft.aufirst=Ruibai&rft.date=2005-12-06&rft.volume=15&rft.issue=23&rft.spage=2164&rft.isbn=&rft.btitle=&rft.title=Current+biology+%3A+CB&rft.issn=09609822&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-12 N1 - Date created - 2005-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - The "Binding Site Barrier" and other Factors that Limit Antibody Penetration into Tumors T2 - 16th Annual International Antibody Engineering Conference (Antibody Engineering) AN - 39828293; 4041305 JF - 16th Annual International Antibody Engineering Conference (Antibody Engineering) AU - Weinstein, John N Y1 - 2005/12/05/ PY - 2005 DA - 2005 Dec 05 KW - Barriers KW - Antibodies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39828293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Annual+International+Antibody+Engineering+Conference+%28Antibody+Engineering%29&rft.atitle=The+%22Binding+Site+Barrier%22+and+other+Factors+that+Limit+Antibody+Penetration+into+Tumors&rft.au=Weinstein%2C+John+N&rft.aulast=Weinstein&rft.aufirst=John&rft.date=2005-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Annual+International+Antibody+Engineering+Conference+%28Antibody+Engineering%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ibclifesciences.com/antibodyeng LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Integrating Hypothesis-Driven and "Omic" Approaches to Cancer Biology, Biomarkers, and Therapeutics T2 - 16th Annual International Antibody Engineering Conference (Antibody Engineering) AN - 39752940; 4041290 JF - 16th Annual International Antibody Engineering Conference (Antibody Engineering) AU - Weinstein, John N Y1 - 2005/12/05/ PY - 2005 DA - 2005 Dec 05 KW - Bioindicators KW - Biomarkers KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39752940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=16th+Annual+International+Antibody+Engineering+Conference+%28Antibody+Engineering%29&rft.atitle=Integrating+Hypothesis-Driven+and+%22Omic%22+Approaches+to+Cancer+Biology%2C+Biomarkers%2C+and+Therapeutics&rft.au=Weinstein%2C+John+N&rft.aulast=Weinstein&rft.aufirst=John&rft.date=2005-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=16th+Annual+International+Antibody+Engineering+Conference+%28Antibody+Engineering%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ibclifesciences.com/antibodyeng LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Error-prone translesion synthesis by human DNA polymerase eta on DNA-containing deoxyadenosine adducts of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene. AN - 68839904; 16188888 AB - When human DNA polymerase eta (pol eta) encounters N6-deoxyadenosine adducts formed by trans epoxide ring opening of the 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BaP DE) isomer with (+)-7R,8S,9S,10R configuration ((+)-BaP DE-2), misincorporation of A or G and incorporation of the correct T are equally likely to occur. On the other hand, the enzyme exhibits a 3-fold preference for correct T incorporation opposite adducts formed by trans ring opening of the (-)-(7S,8R,9R,10S)-DE-2 enantiomer. Adducts at dA formed by cis ring opening of these two BaP DE-2 isomers exhibit a 2-3-fold preference for A over T incorporation, with G intermediate between the two. Extension one nucleotide beyond these adducts is generally weaker than incorporation across from them, but among mismatches the (adducted A*) x A mispair is the most favored for extension. Because mutations can only occur if mispairs are extended, this observation is consistent with the occurrence of A x T to T x A transversions as common mutations in animal cells treated with BaP DE-2 isomers. Adducts with S absolute configuration at the point of attachment of the hydrocarbon to the base inhibit incorporation and extension by pol eta to a lesser extent than their R counterparts. Template-primers containing each of the four isomeric dA adducts derived from BaP DE-2 and two adducts derived from 9,10-epoxy-7,8,9,10-tetrahydrobenzo-[a]pyrene in which the 7- and 8-hydroxyl groups of the DEs are replaced with hydrogens exhibit reduced electrophoretic mobilities relative to the unadducted oligonucleotides. This effect is largely independent of DNA sequence. Decreased mobility correlates with an increased rate of incorporation by pol eta, suggesting a systematic relationship between the overall DNA structure and efficiency of the enzyme. JF - The Journal of biological chemistry AU - Chiapperino, Dominic AU - Cai, Mangmang AU - Sayer, Jane M AU - Yagi, Haruhiko AU - Kroth, Heiko AU - Masutani, Chikahide AU - Hanaoka, Fumio AU - Jerina, Donald M AU - Cheh, Albert M AD - Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, DHHS, Bethesda, Maryland 20892, USA. Y1 - 2005/12/02/ PY - 2005 DA - 2005 Dec 02 SP - 39684 EP - 39692 VL - 280 IS - 48 SN - 0021-9258, 0021-9258 KW - DNA Adducts KW - 0 KW - DNA Primers KW - Deoxyadenosines KW - Hydrocarbons KW - Oligonucleotides KW - 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide KW - 55097-80-8 KW - Hydrogen KW - 7YNJ3PO35Z KW - DNA KW - 9007-49-2 KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Rad30 protein KW - Index Medicus KW - Hydrocarbons -- chemistry KW - Oligonucleotides -- chemistry KW - Hydrogen -- chemistry KW - Electrophoresis, Polyacrylamide Gel KW - Kinetics KW - Humans KW - Models, Chemical KW - Sequence Analysis, DNA KW - Nucleic Acid Conformation KW - Mutation KW - DNA Primers -- chemistry KW - DNA-Directed DNA Polymerase -- physiology KW - DNA Repair KW - Base Pair Mismatch KW - DNA -- chemistry KW - Deoxyadenosines -- chemistry KW - 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide -- chemistry KW - DNA-Directed DNA Polymerase -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68839904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Error-prone+translesion+synthesis+by+human+DNA+polymerase+eta+on+DNA-containing+deoxyadenosine+adducts+of+7%2C8-dihydroxy-9%2C10-epoxy-7%2C8%2C9%2C10-tetrahydrobenzo%5Ba%5Dpyrene.&rft.au=Chiapperino%2C+Dominic%3BCai%2C+Mangmang%3BSayer%2C+Jane+M%3BYagi%2C+Haruhiko%3BKroth%2C+Heiko%3BMasutani%2C+Chikahide%3BHanaoka%2C+Fumio%3BJerina%2C+Donald+M%3BCheh%2C+Albert+M&rft.aulast=Chiapperino&rft.aufirst=Dominic&rft.date=2005-12-02&rft.volume=69&rft.issue=2&rft.spage=430&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Politics&rft.issn=00223816&rft_id=info:doi/10.1111%2Fj.1468-2508.2007.00541.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-03 N1 - Date created - 2005-11-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reactive oxygen species and p38 phosphorylation regulate the protective effect of Delta9-tetrahydrocannabinol in the apoptotic response to NMDA. AN - 68554545; 16098661 AB - NMDA causes oxidative stress in neurons, and produces cell death involving elements of both necrosis and apoptosis. To examine the neuroprotective mechanism of Delta9-tetrahydrocannabinol (THC) in NMDA-induced death of AF5 cells, we measured reactive oxygen species (ROS) formation after exposure to NMDA. ROS generation was increased by NMDA, and NMDA-induced ROS generation was significantly decreased by THC. Western blotting revealed an increase in phosphorylated p38 MAPK after NMDA treatment, which was also blocked by pretreatment with THC. The time course of ROS generation and activation of MAPK signaling pathways were similar. SB203580, a p38 inhibitor, partially blocked glutamate excitotoxicity in AF5 cells. The present data suggest that THC protects against NMDA-induced apoptosis in AF5 cells by blocking ROS generation and inhibiting the activation of p38-MAPK. JF - Neuroscience letters AU - Chen, Jia AU - Errico, Stacie L AU - Freed, William J AD - Development and Plasticity Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA. jchen@intra.nida.nih.gov Y1 - 2005/12/02/ PY - 2005 DA - 2005 Dec 02 SP - 99 EP - 103 VL - 389 IS - 2 SN - 0304-3940, 0304-3940 KW - Enzyme Inhibitors KW - 0 KW - Neuroprotective Agents KW - Neurotoxins KW - Reactive Oxygen Species KW - N-Methylaspartate KW - 6384-92-5 KW - Dronabinol KW - 7J8897W37S KW - p38 Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Animals KW - MAP Kinase Signaling System -- drug effects KW - Neurodegenerative Diseases -- physiopathology KW - MAP Kinase Signaling System -- physiology KW - Dose-Response Relationship, Drug KW - Enzyme Activation -- physiology KW - Phosphorylation -- drug effects KW - Neuroprotective Agents -- pharmacology KW - Oxidative Stress -- physiology KW - Cell Survival -- drug effects KW - Neurodegenerative Diseases -- metabolism KW - Oxidative Stress -- drug effects KW - Enzyme Activation -- drug effects KW - Enzyme Inhibitors -- pharmacology KW - Cell Line, Transformed KW - Cell Survival -- physiology KW - Reactive Oxygen Species -- metabolism KW - p38 Mitogen-Activated Protein Kinases -- antagonists & inhibitors KW - Dronabinol -- pharmacology KW - Apoptosis -- physiology KW - Apoptosis -- drug effects KW - N-Methylaspartate -- toxicity KW - N-Methylaspartate -- antagonists & inhibitors KW - Neurotoxins -- toxicity KW - p38 Mitogen-Activated Protein Kinases -- metabolism KW - Neurotoxins -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68554545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Reactive+oxygen+species+and+p38+phosphorylation+regulate+the+protective+effect+of+Delta9-tetrahydrocannabinol+in+the+apoptotic+response+to+NMDA.&rft.au=Chen%2C+Jia%3BErrico%2C+Stacie+L%3BFreed%2C+William+J&rft.aulast=Chen&rft.aufirst=Jia&rft.date=2005-12-02&rft.volume=389&rft.issue=2&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=03043940&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-24 N1 - Date created - 2005-09-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Physiol Heart Circ Physiol. 2003 Aug;285(2):H822-32 [12714335] Neurosci Res. 2003 Jul;46(3):349-58 [12804796] J Neurochem. 2003 Feb;84(3):566-75 [12558976] J Cell Physiol. 2002 Jul;192(1):1-15 [12115731] Exp Neurol. 2002 Jun;175(2):318-37 [12061863] J Neurochem. 2002 Feb;80(3):448-56 [11905991] Neurochem Res. 2001 May;26(5):525-32 [11513480] J Neurochem. 2001 May;77(3):957-60 [11331425] J Neurosci. 2000 Aug 1;20(15):5715-23 [10908611] Mol Pharmacol. 2000 Oct;58(4):814-20 [10999952] J Physiol. 2001 Feb 15;531(Pt 1):147-63 [11179399] Trends Pharmacol Sci. 1999 Nov;20(11):441-4 [10542441] Neuroreport. 2003 Oct 6;14(14):1815-9 [14534426] Exp Cell Res. 2003 Nov 15;291(1):251-66 [14597424] Neurosci Lett. 1986 May 15;66(2):193-8 [3014386] Brain Res Mol Brain Res. 2005 Apr 4;134(2):215-25 [15836919] Anesth Analg. 2005 Apr;100(4):929-36 [15781500] Rev Pneumol Clin. 2005 Feb;61(1 Pt 1):16-21 [15772575] Mol Cell Neurosci. 2005 Jan;28(1):189-94 [15607953] Annu Rev Physiol. 1998;60:619-42 [9558479] J Biol Chem. 1997 Jul 25;272(30):18518-21 [9228012] Neuron. 1995 Feb;14(2):303-15 [7857640] FEBS Lett. 1995 May 8;364(2):229-33 [7750577] J Biol Chem. 1986 Oct 25;261(30):14201-8 [2876985] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Distinct Protein Classes Including Novel Merozoite Surface Antigens in Raft-like Membranes of Plasmodium falciparum AN - 20254325; 7143458 AB - Glycosylphosphatidylinositol (GPI)-anchored proteins coat the surface of extracellular Plasmodium falciparum merozoites, of which several are highly validated candidates for inclusion in a blood-stage malaria vaccine. Here we determined the proteome of gradient-purified detergent-resistant membranes of mature blood-stage parasites and found that these membranes are greatly enriched in GPI-anchored proteins and their putative interacting partners. Also prominent in detergent-resistant membranes are apical organelle (rhoptry), multimembrane-spanning, and proteins destined for export into the host erythrocyte cytosol. Four new GPI-anchored proteins were identified, and a number of other novel proteins that are predicted to localize to the merozoite surface and/or apical organelles were detected. Three of the putative surface proteins possessed six-cysteine (Cys sub(6)) motifs, a distinct fold found in adhesive surface proteins expressed in other life stages. All three Cys sub(6) proteins, termed Pf12, Pf38, and Pf41, were validated as merozoite surface antigens recognized strongly by antibodies present in naturally infected individuals. In addition to the merozoite surface, Pf38 was particularly prominent in the secretory apical organelles. A different cysteine-rich putative GPI-anchored protein, Pf92, was also localized to the merozoite surface. This insight into merozoite surfaces provides new opportunities for understanding both erythrocyte invasion and anti-parasite immunity. JF - Journal of Biological Chemistry AU - Sanders, Paul R AU - Gilson, Paul R AU - Cantin, Greg T AU - Greenbaum, Doron C AU - Nebl, Thomas AU - Carucci, Daniel J AU - McConville, Malcolm J AU - Schofield, Louis AU - Hodder, Anthony N AU - Yates, John RIII AU - Crabb, Brendan S AD - The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3050 Australia, The Co-operative Research Centre for Vaccine Technology, Australia and the Department of Medical Biology, The University of Melbourne, VIC 3010 Australia, the Department of Cell Biology, The Scripps Research Institute, La, Jolla, California 92037, The Foundation for the National Institutes of Health, Bethesda, Maryland 20814, and the Department of Biochemistry and Molecular Biology, The University of Melbourne, VIC 3050 Australia Y1 - 2005/12/02/ PY - 2005 DA - 2005 Dec 02 SP - 40169 EP - 40176 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org] VL - 280 IS - 48 SN - 0021-9258, 0021-9258 KW - ASFA 3: Aquatic Pollution & Environmental Quality; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Parasites KW - Human diseases KW - Erythrocytes KW - Disease control KW - Malaria KW - Antigens KW - Protein folding KW - Glycosylphosphatidylinositol KW - Adhesives KW - Protein transport KW - Developmental stages KW - Plasmodium falciparum KW - Immunity KW - Antibodies KW - surface antigens KW - Cytosol KW - Merozoites KW - Vaccines KW - Organelles KW - K 03330:Biochemistry KW - W 30915:Pharmaceuticals & Vaccines KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20254325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Distinct+Protein+Classes+Including+Novel+Merozoite+Surface+Antigens+in+Raft-like+Membranes+of+Plasmodium+falciparum&rft.au=Sanders%2C+Paul+R%3BGilson%2C+Paul+R%3BCantin%2C+Greg+T%3BGreenbaum%2C+Doron+C%3BNebl%2C+Thomas%3BCarucci%2C+Daniel+J%3BMcConville%2C+Malcolm+J%3BSchofield%2C+Louis%3BHodder%2C+Anthony+N%3BYates%2C+John+RIII%3BCrabb%2C+Brendan+S&rft.aulast=Sanders&rft.aufirst=Paul&rft.date=2005-12-02&rft.volume=280&rft.issue=48&rft.spage=40169&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Parasites; Human diseases; Antigens; Erythrocytes; Disease control; Malaria; Immunity; Vaccines; Protein transport; Developmental stages; Antibodies; Protein folding; surface antigens; Cytosol; Merozoites; Glycosylphosphatidylinositol; Organelles; Adhesives; Plasmodium falciparum ER - TY - JOUR T1 - Conservation and variation of gene regulation in embryonic stem cells assessed by comparative genomics AN - 864949249; 13857308 AB - We have examined the gene structure and regulatory regions of octamer-binding transcription factor 3/4 (Oct 3/4), sex determining region Y box 2 (Sox2), signal transducer and activator of transcription 3 (Stat3), embryonal stem cell-specific gene 1 (ESG), nanog homeobox (Nanog), and several other genes highly expressed in embryonic stem (ES) cells across different species. Our analysis showed that ES cell-expressed Ras (ERAS) was orthologous to a human pseudogene Harvey Ras (HRASP) and that the promoter and other regulatory sequences were highly divergent. No ortholog of (ES) cell-derived homeobox containing gene (Ehox) could be identified in human, and the closest paralogs PEPP gene subfamily 1 (PEPP1), PEPP2, and extraembryonic, spermatogenesis, homeobox 1 (Esx1) were not expressed by ES cells and shared little homology. The Sox2 promoter was the most conserved across species and the Oct3/4 promoter region showed significant homology particularly in the distal enhancer active in ES cells. Analysis suggested common and divergent pathways of regulation. Conserved Oct3/4 and Sox2 co-binding domains were identified in most ES expressed genes, highlighting the importance of this transcriptional pathway. Conserved fibroblast growth factor response element sites were identified in regulatory regions, suggesting a potential parallel pathway for regulation by FGFs. A central role of Stat3 activation in self-renewal and in a regulatory feedback loop was suggested by the identification of the conserved binding sites in most pathways. Although most pathways were evolutionarily conserved, promoters and genomic structure of the leukemia inhibitory factor (LIF) pathway components were divergent, likely explaining the differential requirement of LIF for human and rodent cells. Our analysis further suggested that the Nanog regulatory pathway was relatively independent of the LIF/Oct pathway and may interact with the Nodal/transforming growth factor-b pathway. These results provide a framework for examining the current reported differences between rodent and human ES cells and define targets for future perturbation studies. JF - Cell Biochemistry and Biophysics AU - Zhan, Ming AU - Miura, Takumi AU - Xu, Xiangru AU - Rao, Mahendra S AD - Stem Cell Section, Laboratory of Neurosciences, National Institute on Aging, NIH, 21224, Baltimore, MD Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 379 EP - 405 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 43 IS - 3 SN - 1085-9195, 1085-9195 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Ras protein KW - Pseudogenes KW - Stat3 protein KW - Leukemia inhibitory factor KW - Regulatory sequences KW - Homeobox KW - Spermatogenesis KW - Promoters KW - Enhancers KW - Stem cells KW - Homology KW - Embryo cells KW - Gene regulation KW - Transcription factors KW - Fibroblast growth factor KW - Transforming growth factor- beta KW - Conservation KW - Transforming growth factor-b KW - Feedback KW - genomics KW - Oct-4 protein KW - Evolution KW - Sex KW - N 14835:Protein-Nucleic Acids Association KW - G 07730:Development & Cell Cycle KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864949249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+Biochemistry+and+Biophysics&rft.atitle=Conservation+and+variation+of+gene+regulation+in+embryonic+stem+cells+assessed+by+comparative+genomics&rft.au=Zhan%2C+Ming%3BMiura%2C+Takumi%3BXu%2C+Xiangru%3BRao%2C+Mahendra+S&rft.aulast=Zhan&rft.aufirst=Ming&rft.date=2005-12-01&rft.volume=43&rft.issue=3&rft.spage=379&rft.isbn=&rft.btitle=&rft.title=Cell+Biochemistry+and+Biophysics&rft.issn=10859195&rft_id=info:doi/10.1385%2FCBB%3A43%3A3%3A379 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-05-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Ras protein; Pseudogenes; Leukemia inhibitory factor; Stat3 protein; Regulatory sequences; Homeobox; Spermatogenesis; Enhancers; Promoters; Stem cells; Embryo cells; Homology; Transcription factors; Gene regulation; Transforming growth factor- beta; Fibroblast growth factor; Transforming growth factor-b; Conservation; Feedback; genomics; Oct-4 protein; Evolution; Sex DO - http://dx.doi.org/10.1385/CBB:43:3:379 ER - TY - JOUR T1 - Automatic Priming of Semantically Related Words Reduces Activity in the Fusiform Gyrus AN - 85632733; 200609750 AB - We used rapid, event-related fMRI to identify the neural systems underlying object semantics. During scanning, subjects silently read rapidly presented word pairs (150 msec, SOA = 250 msec) that were either unrelated in meaning (ankle-carrot), semantically related (fork-cup), or identical (crow-crow). Activity in the left posterior region of the fusiform gyrus & left inferior frontal cortex was modulated by word-pair relationship. Semantically related pairs yielded less activity than unrelated pairs, but greater activity than identical pairs, mirroring the pattern of behavioral facilitation as measured by word reading times. These findings provide strong support for the involvement of these areas in the automatic processing of object meaning. In addition, words referring to animate objects produced greater activity in the lateral region of the fusiform gyri, right superior temporal sulcus, & medial region of the occipital lobe relative to manmade, manipulable objects, whereas words referring to manmade, manipulable objects produced greater activity in the left ventral premotor, left anterior cingulate, & bilateral parietal cortices relative to animate objects. These findings are consistent with the dissociation between these areas based on sensory- & motor-related object properties, providing further evidence that conceptual object knowledge is housed, in part, in the same neural systems that subserve perception & action. 3 Tables, 3 Figures, 1 Appendix, 98 References. Adapted from the source document JF - Journal of Cognitive Neuroscience AU - Wheatley, Thalia AU - Weisberg, Jill AU - Beauchamp, Michael S AU - Martin, Alex AD - Laboratory Brain & Cognition, National Instit Mental Health, National Instits Health, Bethesda MD wheatley@nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1871 EP - 1885 VL - 17 IS - 12 SN - 0898-929X, 0898-929X KW - Animacy and Inanimacy (03100) KW - Cerebral Dominance (11500) KW - Priming (67670) KW - Meaning (52200) KW - Semantic Categories (76580) KW - Semantic Processing (76760) KW - Neuroimaging Techniques (57245) KW - Reading Rate (71250) KW - article KW - 4018: psycholinguistics; neurolinguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85632733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cognitive+Neuroscience&rft.atitle=Automatic+Priming+of+Semantically+Related+Words+Reduces+Activity+in+the+Fusiform+Gyrus&rft.au=Wheatley%2C+Thalia%3BWeisberg%2C+Jill%3BBeauchamp%2C+Michael+S%3BMartin%2C+Alex&rft.aulast=Wheatley&rft.aufirst=Thalia&rft.date=2005-12-01&rft.volume=17&rft.issue=12&rft.spage=1871&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cognitive+Neuroscience&rft.issn=0898929X&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2006-09-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JCONEO N1 - SubjectsTermNotLitGenreText - Neuroimaging Techniques (57245); Priming (67670); Semantic Processing (76760); Semantic Categories (76580); Cerebral Dominance (11500); Meaning (52200); Reading Rate (71250); Animacy and Inanimacy (03100) ER - TY - JOUR T1 - Validity of a modified Parkinson's disease screening questionnaire in India: effects of literacy of participants and medical training of screeners and implications for screening efforts in developing countries. AN - 85396222; pmid-16078206 AB - The prevalence of Parkinson's disease (PD) is low among Indians, except in the Parsis. Data for Indians come from studies using different screening tools and criteria to detect PD. An epidemiological study in India, which has nearly a billion people, more than 18 spoken languages, and varying levels of literacy, requires development and validation of a screening tool for PD. The objectives of this study are to (1) validate a modified version of a widely used screening questionnaire for PD to suit the needs of the Indian population; (2) compare the use of a nonmedical assistant (NMA) with the use of a medical person during screening; and (3) compare the effect of literacy of participants on the validity of the screening tool. The validity of the questionnaire was tested on 125 participants from a home for the elderly. NMAs of similar background and medical personnel administered the modified screening questionnaire. A movement disorder neurologist blind to the responses on the questionnaire, examined participants independently and diagnosed if participants had PD. The questionnaire was validated in the movement disorders clinic, on known PD patients and their family members without PD. In the movement disorders clinic, sensitivity and specificity of the questionnaire were 100% and 89%, respectively. Fifty-seven participants were included for analysis. The questionnaire had a higher sensitivity when NMAs (75%) rather than the medical personnel (61%) administered it, and its specificity was higher with the medical personnel (61%) than with NMAs (55% and 25%). The questionnaire had a higher specificity in literates than illiterates, whereas sensitivity varied considerably. The modified questionnaire translated in a local Indian language had reasonable sensitivity and can be used to screen individuals for PD in epidemiological studies in India. This questionnaire can be administered by NMAs to screen PD and this strategy would reduce manpower costs. Literacy may influence epidemiological estimates when screening PD. JF - Movement disorders : official journal of the Movement Disorder Society AU - Sarangmath, Nagaraja AU - Rattihalli, Rohini AU - Ragothaman, Mona AU - Gopalkrishna, Gururaj AU - Doddaballapur, Subbakrishna AU - Louis, Elan D AU - Muthane, Uday B AD - Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India. Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1550 EP - 1556 VL - 20 IS - 12 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Aged, 80 and over KW - *Developing Countries: statistics & numerical data KW - *Educational Status KW - Female KW - Humans KW - India: epidemiology KW - India: ethnology KW - Interviews as Topic: methods KW - Male KW - *Mass Screening KW - Movement Disorders: diagnosis KW - *Parkinson Disease: diagnosis KW - Parkinson Disease: epidemiology KW - *Professional Role KW - *Questionnaires KW - Reproducibility of Results KW - Sensitivity and Specificity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85396222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Validity+of+a+modified+Parkinson%27s+disease+screening+questionnaire+in+India%3A+effects+of+literacy+of+participants+and+medical+training+of+screeners+and+implications+for+screening+efforts+in+developing+countries.&rft.au=Sarangmath%2C+Nagaraja%3BRattihalli%2C+Rohini%3BRagothaman%2C+Mona%3BGopalkrishna%2C+Gururaj%3BDoddaballapur%2C+Subbakrishna%3BLouis%2C+Elan+D%3BMuthane%2C+Uday+B&rft.aulast=Sarangmath&rft.aufirst=Nagaraja&rft.date=2005-12-01&rft.volume=20&rft.issue=12&rft.spage=1550&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Neural correlates of script event knowledge: a neuropsychological study following prefrontal injury. AN - 85395373; pmid-16350660 AB - Scripts sequentially link information about daily activities and event knowledge. Patients have difficulty sequencing script events following lesions of the prefrontal cortex while showing intact access to selective aspects of script knowledge. It has been suggested that the sequencing impairment is due to a deficit in an inhibitory gating mechanisms that usually enables selection of an item from competing alternatives. If this is the case, then an inhibitory task should reveal script processing impairments on a script categorization task that is not normally associated with poor performance following prefrontal damage. To test this hypothesis, we administered a simple untimed classification task and a modified Go/NoGo task in which subjects classified events from social and non-social activities (e.g., read the menu, order the food) and related semantic items (e.g., menu, order) in terms of whether they belonged to a target activity. Participants were patients with lesions of the prefrontal cortex and matched controls. The results showed that damage to the right orbitofrontal cortex was associated with social item classification errors in the simple untimed classification task. In addition, the damage to the right prefrontal cortex was associated with increased response times to respond correctly to Go trials in the modified Go/NoGo task. The data demonstrate that damage to the right orbitofrontal cortex results in impairment in the accessibility of script and semantic representations of social activities. This impairment is exacerbated by an inefficient inhibitory gating mechanism. JF - Cortex; a journal devoted to the study of the nervous system and behavior AU - Wood, Jacqueline N AU - Tierney, Michael AU - Bidwell, Laura A AU - Grafman, Jordan AD - Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1440, USA. Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 796 EP - 804 VL - 41 IS - 6 SN - 0010-9452, 0010-9452 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - Female KW - *Functional Laterality: physiology KW - Humans KW - Magnetic Resonance Imaging KW - Male KW - *Mental Processes: physiology KW - Middle Aged KW - *Neuropsychological Tests KW - *Prefrontal Cortex: pathology KW - Prefrontal Cortex: radiography KW - Psychomotor Performance: physiology KW - Reaction Time: physiology KW - Social Behavior KW - Stroke: pathology KW - *Stroke: psychology KW - Stroke: radiography KW - Tomography, X-Ray Computed UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85395373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cortex%3B+a+journal+devoted+to+the+study+of+the+nervous+system+and+behavior&rft.atitle=Neural+correlates+of+script+event+knowledge%3A+a+neuropsychological+study+following+prefrontal+injury.&rft.au=Wood%2C+Jacqueline+N%3BTierney%2C+Michael%3BBidwell%2C+Laura+A%3BGrafman%2C+Jordan&rft.aulast=Wood&rft.aufirst=Jacqueline&rft.date=2005-12-01&rft.volume=41&rft.issue=6&rft.spage=796&rft.isbn=&rft.btitle=&rft.title=Cortex%3B+a+journal+devoted+to+the+study+of+the+nervous+system+and+behavior&rft.issn=00109452&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Taiwanese cases of SCA2 are derived from a single founder. AN - 85391554; pmid-16078202 AB - We have assessed the haplotypes at the ATXN2 locus in Taiwanese controls and in individuals with SCA2 ataxia with both ataxic and parkinsonian features. Our intention was to determine whether a different ataxin 2 haplotypes predisposed to the two phenotypes. In fact, our analysis showed that all SCA2 mutations carriers had the same ataxin 2 haplotype: haplotype B, which accounts for only 15% of control haplotypes, implying that there is a common founder for all Taiwanese SCA2 patients. JF - Movement disorders : official journal of the Movement Disorder Society AU - Momeni, Parastoo AU - Lu, Chin-Song AU - Chou, Yah-Huei Wu AU - Chang, Hsiu-Chen AU - Chen, Rou-Shayn AU - Chen, Chiung-Chu AU - Hsu, Jin-Tian AU - Singleton, Andrew AU - Hardy, John AD - Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20952, USA. momeni@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1633 EP - 1636 VL - 20 IS - 12 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - *Ataxia: genetics KW - DNA Mutational Analysis KW - Female KW - Gene Frequency KW - Genetic Predisposition to Disease KW - Haplotypes KW - Humans KW - Male KW - Middle Aged KW - *Nerve Tissue Proteins: genetics KW - Parkinson Disease: genetics KW - *Polymorphism, Single Nucleotide: genetics KW - Taiwan: ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85391554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Taiwanese+cases+of+SCA2+are+derived+from+a+single+founder.&rft.au=Momeni%2C+Parastoo%3BLu%2C+Chin-Song%3BChou%2C+Yah-Huei+Wu%3BChang%2C+Hsiu-Chen%3BChen%2C+Rou-Shayn%3BChen%2C+Chiung-Chu%3BHsu%2C+Jin-Tian%3BSingleton%2C+Andrew%3BHardy%2C+John&rft.aulast=Momeni&rft.aufirst=Parastoo&rft.date=2005-12-01&rft.volume=20&rft.issue=12&rft.spage=1633&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Normal tissue radiosensitivity: prediction on deterministic or stochastic basis? AN - 70180125; 17102816 AB - For the same standardized physical radiation dose there is considerable variation, among different patients, of the magnitude of early and late normal tissue reactions. Technical and clinical factors account for about one third only of these variations. Genetic or epigenetic differences between patients account for the greater proportion of interpatient radiosensitivity differences. Attempts have been made to correlate differences in the tissue radiosensitivity with the in vitro radiosensitivity of fibroblasts or lymphocytes as well as with other biological cellular processes related to cell death (mainly DNA repair and chromosomal aberrations). Apart from some genetic diseases such as ataxia telangiectasia, there were positive results in some studies that could not be reproduced in others. It is now realized that for normal tissue radiation-induced morbidity (a) cell kill is not the only factor, (b) interaction with a large number of gene products, such as IL-2, IL-6, TGF-beta, is involved, and (c) radiosensitivity differences can reflect genetic differences. Polymorphism in a wide range of genes can now be demonstrated and analyzed as a source of variations in the radiation response. cDNA microarray procedures can also allow simultaneous measurement, in the same sample, of thousands of genes and thus avoiding basing the investigation on a restricted number of genes. Preliminary results could show retrospectively a correlation between late normal tissue reactions and expression of certain genes. Using cDNA microarray before radiotherapy to predict the occurrence of serious late reactions is still under consideration. Theoretically, an efficient predictor procedure may serve in (a) detection of hypersensitive patients before submitting them to highly toxic radiotherapy regimes such as whole body irradiation, (b) detection of hypersensitive patients in clinical situations where radiotherapy can be effectively replaced by other modalities, and (c) selection of patients for elaborate radiotherapy techniques involving dose escalation to high levels. JF - Journal of the Egyptian National Cancer Institute AU - Awwad, Hassan K AD - The Department of Radiotherapy, National Cancer Institute, Cairo University. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 221 EP - 230 VL - 17 IS - 4 SN - 1110-0362, 1110-0362 KW - Index Medicus KW - Polymorphism, Genetic KW - Dose Fractionation KW - Humans KW - Dose-Response Relationship, Radiation KW - Radiation Tolerance -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70180125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Diminished+Lipoxin+Biosynthesis+in+Severe+Asthma&rft.au=Levy%2C+Bruce+D%3BBonnans%2C+Caroline%3BSilverman%2C+Eric+S%3BPalmer%2C+Lyle+J%3Bet+al&rft.aulast=Levy&rft.aufirst=Bruce&rft.date=2005-10-01&rft.volume=172&rft.issue=7&rft.spage=824&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-06 N1 - Date created - 2006-11-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Abatement by naringenin of doxorubicin-induced cardiac toxicity in rats. AN - 70178993; 17102822 AB - Doxorubicin is one of the most active cytotoxic agents in current use. It has proven efficacy in various malignancies either alone or combined with other cytocidal agents. The clinical usefulness of the anthracycline drug has been precluded by cardiac toxicity. Many therapeutic interventions have been attempted to improve the therapeutic benefits of the drug. Few, however, have been efficacious in this setting. We have addressed in the current study the possible protective effects of naringenin, a flavonoid known to have anti-oxidant properties, on doxorubicin-induced cardiac toxicity in male Swiss albino rats. Forty male Swiss albino rats were used in this study. Naringenin (25 mg/kg body weight) was administered daily by gavage for 7 consecutive days before a cumulative single dose of doxorubicin (15 mg/kg body weight, ip). Doxorubicin induced marked biochemical alterations characteristic of cardiac toxicity including, elevated activities of serum total lactate dehydrogenase (LDH) and creatine phosphokinase (CPK), enhanced lipid peroxidation measured as malondialdehyde (MDA). The anthracycline drug has also reduced the cardiac enzymatic activities of superoxide dismutase (SOD), glutathione-S-transferase (GST) and catalase (CAT). Besides, it reduced significantly the reduced glutathione (GSH) level, but it increased the total NO content in heart tissue. Prior administration of naringenin ahead of doxorubicin challenge ameliorated all these biochemical markers. Taken together, one could conclude that naringenin has a protective role in the abatement of doxorubicin-induced cardiac toxicity that resides, at least in part, on its anti-radical effects and regulatory role on NO production. JF - Journal of the Egyptian National Cancer Institute AU - Arafa, Hossam M AU - Abd-Ellah, Mohamed F AU - Hafez, Hafez F AD - The Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, National Cancer Institute, Cairo University. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 291 EP - 300 VL - 17 IS - 4 SN - 1110-0362, 1110-0362 KW - Antibiotics, Antineoplastic KW - 0 KW - Antioxidants KW - Flavanones KW - Nitric Oxide KW - 31C4KY9ESH KW - Doxorubicin KW - 80168379AG KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Catalase KW - EC 1.11.1.6 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Creatine Kinase KW - EC 2.7.3.2 KW - naringenin KW - HN5425SBF2 KW - Index Medicus KW - Animals KW - Creatine Kinase -- drug effects KW - L-Lactate Dehydrogenase -- drug effects KW - Glutathione Transferase -- metabolism KW - Lipid Peroxidation -- drug effects KW - Superoxide Dismutase -- metabolism KW - Nitric Oxide -- metabolism KW - Superoxide Dismutase -- drug effects KW - Rats KW - Catalase -- metabolism KW - Creatine Kinase -- blood KW - L-Lactate Dehydrogenase -- blood KW - Catalase -- drug effects KW - Glutathione Transferase -- drug effects KW - Male KW - Doxorubicin -- adverse effects KW - Flavanones -- therapeutic use KW - Heart Diseases -- chemically induced KW - Antioxidants -- therapeutic use KW - Heart Diseases -- prevention & control KW - Antibiotics, Antineoplastic -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70178993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Egyptian+National+Cancer+Institute&rft.atitle=Abatement+by+naringenin+of+doxorubicin-induced+cardiac+toxicity+in+rats.&rft.au=Arafa%2C+Hossam+M%3BAbd-Ellah%2C+Mohamed+F%3BHafez%2C+Hafez+F&rft.aulast=Arafa&rft.aufirst=Hossam&rft.date=2005-12-01&rft.volume=17&rft.issue=4&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Egyptian+National+Cancer+Institute&rft.issn=11100362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-06 N1 - Date created - 2006-11-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of neurotoxic potential by use of in vitro systems. AN - 70170689; 16863434 AB - In vitro systems have been proposed, but not yet demonstrated, as a method to assess the neurotoxicity of compounds in an efficient and rapid manner. Although such tests are desired both for pharmaceuticals and environmental agents, such a battery has yet to be developed that is based on known processes of nervous system dysfunction. In this review article, characteristics and potential limitations associated with in vitro methods are discussed. Many of these features have been identified from a larger body of work examining the neurotoxicity of environmental agents and the mechanisms underlying activity of known neurotoxicants. These issues include relevant drug concentrations, factors that limit or alter drug accessibility to the nervous system, and the need for assays to reflect biologically meaningful end points. This commentary briefly surveys in vitro systems of increasing biological complexity currently available for toxicity testing, from single cell types to systems that preserve some aspects of tissue structure and function. A small number of studies to evaluate drugs for cytotoxicity and biological responses in vitro are presented as representative of the current state of the field and to provide a reference and direction for additional development of methods to assess a compound's potential for neurotoxicity. JF - Expert opinion on drug metabolism & toxicology AU - Harry, Gaylia Jean AU - Tiffany-Castiglioni, Evelyn AD - National Institutes of Health, Laboratory of Neurobiology, National Institute of Environmental Health Sciences, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. harry@niehs.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 701 EP - 713 VL - 1 IS - 4 SN - 1742-5255, 1742-5255 KW - Index Medicus KW - Animals KW - Animal Testing Alternatives KW - Cell Survival -- drug effects KW - Neurites -- drug effects KW - Humans KW - Learning -- drug effects KW - Neurites -- physiology KW - Organ Culture Techniques KW - Cell Line KW - Blood-Brain Barrier KW - Nervous System -- drug effects KW - Toxicity Tests -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70170689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.atitle=Evaluation+of+neurotoxic+potential+by+use+of+in+vitro+systems.&rft.au=Harry%2C+Gaylia+Jean%3BTiffany-Castiglioni%2C+Evelyn&rft.aulast=Harry&rft.aufirst=Gaylia&rft.date=2005-12-01&rft.volume=1&rft.issue=4&rft.spage=701&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.issn=17425255&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-16 N1 - Date created - 2006-07-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of loss of heterozygosity on chromosomes 8 and 9 in the development and progression of cancer bladder. AN - 70168569; 17102820 AB - Loss of heterozygosity (LOH) in tumor samples is believed to be a marker for the absence of a functional tumor suppressor gene. Non-random chromosome deletion and LOH at specific chromosomal regions are identified in a number of common human cancers including carcinoma of the bladder, which is considered the most predominant cancer in Egypt due to the prevalence of schistosomiasis. The main objective of the present study is to clarify the role of chromosomes 8 and 9 in the establishment and/or progression of schistosomiasis-related bladder cancer through detection of LOH of 8 microsatellite markers on both chromosomes. It also aims to compare the LOH pattern of the tested markers between schistosomiasis- associated and non schistosomiasis-associated bladder cancer. To achieve this purpose, DNA was extracted from the tumor specimens and the corresponding peripheral blood samples of 42 primary bladder cancer patients (schistosomal and non schistosomal). Twenty nine of these were diagnosed as squamous cell type (SCC), 11 were transitional (TCC), and 2 were adenocarcinoma (with different stages and grades). LOH at chromosomes 8 and 9 was evaluated for 8 highly polymorphic microsatellite markers distributed at different regions of both chromosomes using the dinucleotide repeat-PCR technique. The overall percentage of LOH in chromosome 8 was 74% in at least one marker. The highest incidence of LOH was recorded for D8S84 (41%) followed by 37% for D8S87, 29% for D8S85, and 25% for D8S88. Deletions at chromosome 8 were shown to be associated with high grade of the tumor and LOH at D8S85 was associated with metastatic lymph nodes. The overall percentage of LOH in chromosome 9 was 54% and its highest incidence was for D9S126 (36%), followed by 26%, 21%, 19% for D9S166, D9S128 and D9S180, respectively. Fifty nine percent (59%) of the cases with LOH at 9q were diagnosed as squamous cell type (SCC), whereas 9% only were transitional cell type (TCC). No significant association was recorded between the presence of schistosomiasis and LOH detected in all markers used in this study. Our data indicate that more than one tumor suppressor gene on chromosomes 8 and 9 are involved in high grades of bladder carcinogenesis, one at 8p12 and another at 8q21.1 regions. Also, a region at 8q23-quarter may harbor tumor suppressor gene that involved in metastasis of bladder cancer. Our study also revealed that 9p21 (p16INK4) region is involved in both types of the tumor (SCC & TCC). PTCH located at 9q22.3, as well as the TSC gene at 9q34 are involved in squamous cell carcinoma rather than transitional carcinoma. Region 9q12-13 is considered to be a critical region of urothelial tumor suppressor genes. Finally, the present study shows no line of demarcation between schistosomiasis-associate and non schistosomiasis-associated bladder cancer in terms of LOH of the tested microsatellite markers on chromosome 8 and 9. This suggests that data obtained from schistosoma-associated bladder cancer can be extrapolated to bladder cancer induced by a schistosomiasis independent mechanism. JF - Journal of the Egyptian National Cancer Institute AU - Abdel Wahab, Abdel Hady A AU - Abo-Zeid, Hamdy I AU - El-Husseini, Motawa I AU - Ismail, Mohsein AU - El-Khor, Akmal M AD - The Department of Biochemistry & Molecular Biology Unit, NCI, Cairo University. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 260 EP - 269 VL - 17 IS - 4 SN - 1110-0362, 1110-0362 KW - DNA, Neoplasm KW - 0 KW - Index Medicus KW - Polymerase Chain Reaction KW - Microsatellite Repeats KW - Humans KW - Disease Progression KW - DNA, Neoplasm -- analysis KW - Loss of Heterozygosity KW - Schistosomiasis haematobia -- complications KW - Urinary Bladder Neoplasms -- genetics KW - Chromosomes, Human, Pair 8 -- genetics KW - Urinary Bladder Neoplasms -- microbiology KW - Chromosomes, Human, Pair 9 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70168569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Egyptian+National+Cancer+Institute&rft.atitle=Role+of+loss+of+heterozygosity+on+chromosomes+8+and+9+in+the+development+and+progression+of+cancer+bladder.&rft.au=Abdel+Wahab%2C+Abdel+Hady+A%3BAbo-Zeid%2C+Hamdy+I%3BEl-Husseini%2C+Motawa+I%3BIsmail%2C+Mohsein%3BEl-Khor%2C+Akmal+M&rft.aulast=Abdel+Wahab&rft.aufirst=Abdel+Hady&rft.date=2005-12-01&rft.volume=17&rft.issue=4&rft.spage=260&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Egyptian+National+Cancer+Institute&rft.issn=11100362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-06 N1 - Date created - 2006-11-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Weight of evidence: a review of concept and methods. AN - 70146526; 16506981 AB - "Weight of evidence" (WOE) is a common term in the published scientific and policy-making literature, most often seen in the context of risk assessment (RA). Its definition, however, is unclear. A systematic review of the scientific literature was undertaken to characterize the concept. For the years 1994 through 2004, PubMed was searched for publications in which "weight of evidence" appeared in the abstract and/or title. Of the 276 papers that met these criteria, 92 were selected for review: 71 papers published in 2003 and 2004 (WOE appeared in abstract/title) and 21 from 1994 through 2002 (WOE appeared in title). WOE has three characteristic uses in this literature: (1) metaphorical, where WOE refers to a collection of studies or to an unspecified methodological approach; (2) methodological, where WOE points to established interpretative methodologies (e.g., systematic narrative review, meta-analysis, causal criteria, and/or quality criteria for toxicological studies) or where WOE means that "all" rather than some subset of the evidence is examined, or rarely, where WOE points to methods using quantitative weights for evidence; and (3) theoretical, where WOE serves as a label for a conceptual framework. Several problems are identified: the frequent lack of definition of the term "weight of evidence," multiple uses of the term and a lack of consensus about its meaning, and the many different kinds of weights, both qualitative and quantitative, which can be used in RA. A practical recommendation emerges: the WOE concept and its associated methods should be fully described when used. A research agenda should examine the advantages of quantitative versus qualitative weighting schemes, how best to improve existing methods, and how best to combine those methods (e.g., epidemiology's causal criteria with toxicology's quality criteria). JF - Risk analysis : an official publication of the Society for Risk Analysis AU - Weed, Douglas L AD - National Cancer Institute, Rockville, MD 20852, USA. dw102i@nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1545 EP - 1557 VL - 25 IS - 6 SN - 0272-4332, 0272-4332 KW - Index Medicus KW - Public Health KW - Epidemiology KW - Humans KW - Meta-Analysis as Topic KW - Toxicology KW - Risk Assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70146526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+education+and+prevention&rft.atitle=Epidemiology+of+HIV%2FAIDS+among+Asians+and+Pacific+islanders+in+the+United+States&rft.au=Zaidi%2C+Irum+F%3BCrepaz%2C+Nicole%3BSong%2C+Ruiguang%3BWan%2C+Choi+K%3BLin%2C+Lillian+S%3BHu%2C+Dale+J%3BSy%2C+Francisco+S&rft.aulast=Zaidi&rft.aufirst=Irum&rft.date=2005-10-01&rft.volume=17&rft.issue=5&rft.spage=405&rft.isbn=&rft.btitle=&rft.title=AIDS+education+and+prevention&rft.issn=08999546&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-20 N1 - Date created - 2006-03-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Risk Anal. 2006 Jun;26(3):573-5; author reply 577 [16834614] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A slow disengagement from platinum-based chemotherapy for patients with advanced non-small cell lung cancer. AN - 70112277; 16434876 JF - Cancer biology & therapy AU - Ballas, Marc S AU - Dennis, Phillip A AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20889, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1316 EP - 1317 VL - 4 IS - 12 SN - 1538-4047, 1538-4047 KW - irinotecan KW - 0H43101T0J KW - Platinum KW - 49DFR088MY KW - Paclitaxel KW - P88XT4IS4D KW - Camptothecin KW - XT3Z54Z28A KW - Index Medicus KW - Paclitaxel -- administration & dosage KW - Drug Administration Schedule KW - Diarrhea -- chemically induced KW - Paclitaxel -- adverse effects KW - Survival Rate KW - Humans KW - Camptothecin -- analogs & derivatives KW - Neutropenia -- chemically induced KW - Maximum Tolerated Dose KW - Camptothecin -- adverse effects KW - Time Factors KW - Camptothecin -- administration & dosage KW - Carcinoma, Non-Small-Cell Lung -- mortality KW - Platinum -- therapeutic use KW - Lung Neoplasms -- drug therapy KW - Lung Neoplasms -- mortality KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Lung Neoplasms -- pathology KW - Carcinoma, Non-Small-Cell Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70112277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+biology+%26+therapy&rft.atitle=A+slow+disengagement+from+platinum-based+chemotherapy+for+patients+with+advanced+non-small+cell+lung+cancer.&rft.au=Ballas%2C+Marc+S%3BDennis%2C+Phillip+A&rft.aulast=Ballas&rft.aufirst=Marc&rft.date=2005-12-01&rft.volume=4&rft.issue=12&rft.spage=1316&rft.isbn=&rft.btitle=&rft.title=Cancer+biology+%26+therapy&rft.issn=15384047&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-22 N1 - Date created - 2006-02-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Cancer Biol Ther. 2005 Dec;4(12):1311-5 [16258263] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Imatinib synergizes with donor lymphocyte infusions to achieve rapid molecular remission of CML relapsing after allogeneic stem cell transplantation. AN - 69062281; 16205732 AB - Donor lymphocyte infusions (DLI) have been the mainstay of treatment for chronic myeloid leukemia (CML) relapsing after allogeneic stem cell transplantation (allo-SCT). Imatinib mesylate (IM) is also effective in these patients. However, advanced phase relapse (APRel) responds poorly with either treatment. To test the possibility that combinations of DLI and IM might be more effective, 37 patients with CML relapsing after allo-SCT between August 1994 and May 2004 were studied. Ten had molecular relapse (MRel), 14 hematological relapse (HRel) and 13 APRel. Thirteen received DLI, 9 IM and 11 DLI+IM. Four patients received DLI+IM but not concurrently. Thirty (81%) patients responded (actuarial survival and current leukemia-free survival of 80.6 +/- 6.7% and 69.1 +/- 7.7%). Of 30 patients, 26 are in molecular remission (MR), median follow-up of 1,226 days (range 249-3257) since relapse. Ten of 11 patients (including four with APRel) treated with DLI+IM achieved MR in 3 months and all are alive in MR. In contrast, only two of 22 treated with either modality (1/13 DLI and 1/9 IM) achieved MR at 3 months, 15 are alive, 11 in MR. Four patients receiving nonconcurrent DLI+IM are also alive in MR. In conclusion, DLI appears to synergize with IM to induce rapid and durable MR. JF - Bone marrow transplantation AU - Savani, B N AU - Montero, A AU - Kurlander, R AU - Childs, R AU - Hensel, N AU - Barrett, A J AD - Stem Cell Allogeneic Transplantation Section, Hematology Branch, NHLBI, National Institutes of Health, Building 10, Hatfield CRC, 10 Center Drive MSC 1202, Bethesda, MD 20892-1202, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1009 EP - 1015 VL - 36 IS - 11 SN - 0268-3369, 0268-3369 KW - Benzamides KW - 0 KW - Piperazines KW - Pyrimidines KW - Imatinib Mesylate KW - 8A1O1M485B KW - Index Medicus KW - Humans KW - Adult KW - Retrospective Studies KW - Aged KW - Remission Induction -- methods KW - Middle Aged KW - Transplantation, Homologous KW - Drug Synergism KW - Adolescent KW - Recurrence KW - Male KW - Female KW - Survival Analysis KW - Lymphocyte Transfusion KW - Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- mortality KW - Hematopoietic Stem Cell Transplantation KW - Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- therapy KW - Pyrimidines -- administration & dosage KW - Piperazines -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69062281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bone+marrow+transplantation&rft.atitle=Imatinib+synergizes+with+donor+lymphocyte+infusions+to+achieve+rapid+molecular+remission+of+CML+relapsing+after+allogeneic+stem+cell+transplantation.&rft.au=Savani%2C+B+N%3BMontero%2C+A%3BKurlander%2C+R%3BChilds%2C+R%3BHensel%2C+N%3BBarrett%2C+A+J&rft.aulast=Savani&rft.aufirst=B&rft.date=2005-12-01&rft.volume=36&rft.issue=11&rft.spage=1009&rft.isbn=&rft.btitle=&rft.title=Bone+marrow+transplantation&rft.issn=02683369&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-03 N1 - Date created - 2006-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of fluorenhymustine as a rationally designed novel anticancer agent. AN - 69061070; 16404347 AB - To develop a rationally designed new nitrogen mustard namely Fluorenhymustine (compound 2), where N,N'-bis(2chloro-ethyl)amino group, the established anticancer functionality, is attached to the 2-ethyl fluorenone hydantoin moiety. Starting from fluorenone hydantoin, a 3-step synthetic procedure was followed to obtain the title compound. 4-(4-Nitrobenzyl)pyridine was used to assess its chemical alkylating activity. Murine tumors (Ehrlich ascites carcinoma (EAC) and Sarcoma-180 (S-180)) were used to assess its in vivo activity. Its cytotoxicity was determined in vitro in MCF-7 human breast tumor cell line, toxicity - in vivo in normal and EAC bearing mice. 3H-Thymidine and 3H-Uridine were employed to study its inhibitory effect on DNA and RNA synthesis respectively in S-180 tumor cells in vitro. Alkylating activity of fluorenmustine exceeded that of N-di(2-chloroethyl)amine used as a standard alkylating compound. It has displayed an excellent and reproducible antitumor activity in vivo against EAC and S-180 comparable to that of 5-fluorouracil judging by the increase in median survival times of treated animals. It also significantly increased the life span of mice bearing advanced tumors for 6 days before the drug challenge. However in vitro screening in MCF-7 did not reveal any significant cytotoxicity. The compound did not adversely affect hematopoiesis at its optimum dose. Drug-induced hepatotoxicity and nephrotoxicity were also not detected. It inhibited the synthesis of DNA and RNA in S-180 tumor cells at 8 microM concentration. Results indicated promising chemotherapeutic potential of Fluorenhymustine. JF - Experimental oncology AU - Samanta, S AU - Pain, A AU - Ghosh, M AU - Dutta, S AU - Sanyal, U AD - Department of Anticancer Drug Development, Chittaranjan National Cancer Institute, Calcutta 700026, India. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 279 EP - 285 VL - 27 IS - 4 SN - 1812-9269, 1812-9269 KW - Antineoplastic Agents, Alkylating KW - 0 KW - Nitrogen Mustard Compounds KW - fluorenhymustine KW - Index Medicus KW - Drug Screening Assays, Antitumor KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Mice KW - Cell Line, Tumor KW - Drug Evaluation, Preclinical KW - Antineoplastic Agents, Alkylating -- chemical synthesis KW - Antineoplastic Agents, Alkylating -- pharmacology KW - Nitrogen Mustard Compounds -- chemical synthesis KW - Neoplasms, Experimental -- drug therapy KW - Nitrogen Mustard Compounds -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69061070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+oncology&rft.atitle=Evaluation+of+fluorenhymustine+as+a+rationally+designed+novel+anticancer+agent.&rft.au=Samanta%2C+S%3BPain%2C+A%3BGhosh%2C+M%3BDutta%2C+S%3BSanyal%2C+U&rft.aulast=Samanta&rft.aufirst=S&rft.date=2005-12-01&rft.volume=27&rft.issue=4&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Experimental+oncology&rft.issn=18129269&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-02 N1 - Date created - 2006-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - [Social aspects and cancer: information dedicated to cancer patients and relatives]. TT - Démarches sociales et cancer Information à l'usage des personnes malades et de leurs proches. AN - 69054045; 16396756 AB - In response to the evolution of the information-seeking behaviour of patients and concerns from health professionals regarding cancer patient information, the French National Federation of Comprehensive Cancer Centres (FNCLCC) introduced, in 1998, an information and education program dedicated to patients and relatives, the SOR SAVOIR PATIENT program (SSP). The methodology of this program adheres to established quality criteria regarding the elaboration of patient information. Cancer patient information, developed in this program, is based on clinical practice guidelines produced by the FNCLCC and the twenty French regional cancer centres, the National League against Cancer, The National Cancer Institute, the French Hospital Federation, the National Oncology Federation of Regional and University Hospitals, the French Oncology Federation of General Hospitals, many learned societies, as well as an active participation of patients, former patients and caregivers. The information and dialogue handbook SOR SAVOIR PATIENT Social aspects & cancer partly published in this edition of the Bulletin du cancer, provides specific information regarding patient social rights and benefits extracted from the texts of laws currently in force in France. It also relies on the handbook A "Prévoir Demain, La réinsertion des patients traités pour cancers A", realised in partnership with the FNCLCC, the Coloplast foundation for quality of life and the National League against Cancer. This document is available from the FNCLCC (101, rue de Tolbiac, 75013 Paris, Tel. (0033) 1 44 23 04 68, www.fnclcc.fr). The handbook A "Social aspects & cancer A" was worked out and published in 2004. Information may change with new legal regulations. It is therefore strongly advised to refer to the texts of laws in force to check for possible amendments. This article aims to help patients and relatives to be better aware of their social rights, to locate the different social and administrative services concerned (CAF, Cotorep, etc.) and to turn to the right person and the appropriate agency in the event of social difficulties during and after the disease. This document is designed to offer health professionals a validated information digest of all resources available in order to better communicate with the patient on social aspects of cancer. JF - Bulletin du cancer AU - FNCLCC AU - French regional cancer centres AU - National League against Cancer AU - National Cancer Institute AU - French Hospital Federation AU - National Oncology Federation of Regional and University Hospitals AU - French Oncology Federation of General Hospitals AD - FNCLCC ; French regional cancer centres ; National League against Cancer ; National Cancer Institute ; French Hospital Federation ; National Oncology Federation of Regional and University Hospitals ; French Oncology Federation of General Hospitals Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1093 EP - 1113 VL - 92 IS - 12 KW - Index Medicus KW - France KW - Humans KW - Program Development KW - Home Care Services -- organization & administration KW - Guidelines as Topic KW - Occupational Diseases -- therapy KW - Patient Education as Topic KW - Family KW - Neoplasms -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69054045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bulletin+du+cancer&rft.atitle=%5BSocial+aspects+and+cancer%3A+information+dedicated+to+cancer+patients+and+relatives%5D.&rft.au=FNCLCC%3BFrench+regional+cancer+centres%3BNational+League+against+Cancer%3BNational+Cancer+Institute%3BFrench+Hospital+Federation%3BNational+Oncology+Federation+of+Regional+and+University+Hospitals%3BFrench+Oncology+Federation+of+General+Hospitals&rft.aulast=FNCLCC&rft.aufirst=&rft.date=2005-12-01&rft.volume=92&rft.issue=12&rft.spage=1093&rft.isbn=&rft.btitle=&rft.title=Bulletin+du+cancer&rft.issn=1769-6917&rft_id=info:doi/ LA - fre DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-19 N1 - Date created - 2006-01-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A pilot study to evaluate the vascular endothelial growth factor receptor tyrosine kinase inhibitor AZD2171 and chemotherapy in locally advanced and inflammatory breast cancer. AN - 69047013; 16381631 JF - Clinical breast cancer AU - Denduluri, Neelima AU - Tan, Antoinette R AU - Walshe, Janice AU - Berman, Arlene AU - Yang, Sherry X AU - Chow, Catherine K AU - Swain, Sandra M AD - Breast Cancer Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 460 EP - 463 VL - 6 IS - 5 SN - 1526-8209, 1526-8209 KW - Enzyme Inhibitors KW - 0 KW - Quinazolines KW - Receptors, Vascular Endothelial Growth Factor KW - EC 2.7.10.1 KW - cediranib KW - NQU9IPY4K9 KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Clinical Trials, Phase II as Topic KW - Humans KW - Inflammation -- drug therapy KW - Pilot Projects KW - Female KW - Breast Neoplasms -- drug therapy KW - Enzyme Inhibitors -- adverse effects KW - Receptors, Vascular Endothelial Growth Factor -- antagonists & inhibitors KW - Enzyme Inhibitors -- therapeutic use KW - Quinazolines -- therapeutic use KW - Breast Neoplasms -- etiology KW - Quinazolines -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69047013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+breast+cancer&rft.atitle=A+pilot+study+to+evaluate+the+vascular+endothelial+growth+factor+receptor+tyrosine+kinase+inhibitor+AZD2171+and+chemotherapy+in+locally+advanced+and+inflammatory+breast+cancer.&rft.au=Denduluri%2C+Neelima%3BTan%2C+Antoinette+R%3BWalshe%2C+Janice%3BBerman%2C+Arlene%3BYang%2C+Sherry+X%3BChow%2C+Catherine+K%3BSwain%2C+Sandra+M&rft.aulast=Denduluri&rft.aufirst=Neelima&rft.date=2005-12-01&rft.volume=6&rft.issue=5&rft.spage=460&rft.isbn=&rft.btitle=&rft.title=Clinical+breast+cancer&rft.issn=15268209&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-26 N1 - Date created - 2005-12-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Concepts and clinical trials of dose-dense chemotherapy for breast cancer . AN - 69043758; 16381623 AB - This article will review the strategy of dose-dense administration of chemotherapy for breast cancer. Increased dose density is achieved by reducing the interval between each dose of chemotherapy. The cumulative drug dose remains constant, but the same amount of drug is administered over a shorter period. Mathematical models of tumor growth have provided the basis for the clinical application of dose-dense chemotherapy. The Norton-Simon model suggests that increasing the dose density of chemotherapy will increase efficacy by minimizing the opportunity for regrowth of tumor cells between cycles of chemotherapy. Intergroup trial 9741, coordinated by the Cancer and Leukemia Group B (CALGB), tested the 2 hypotheses that dose-dense and sequential administration of chemotherapy regimens incorporating doxorubicin, cyclophosphamide, and paclitaxel would improve disease-free survival and overall survival. A statistically significant 4-year disease-free survival advantage was detected for the 2 dose-dense regimens compared with the regimens administered every 3 weeks. The mathematical concepts and previous clinical trials of dose density that contributed to the design of CALGB 9741 will be reviewed. The strengths and limitations of CALGB 9741 will then be discussed before the presentation of future directions of research and recommendations for clinical practice today. JF - Clinical breast cancer AU - Orzano, Jennifer A AU - Swain, Sandra M AD - Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Department of Health & Human Services, Bethesda, MD, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 402 EP - 411 VL - 6 IS - 5 SN - 1526-8209, 1526-8209 KW - Taxoids KW - 0 KW - Index Medicus KW - Humans KW - Clinical Trials as Topic KW - Models, Biological KW - Female KW - Mathematics KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- pathology KW - Dose-Response Relationship, Drug KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Taxoids -- toxicity KW - Taxoids -- therapeutic use KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Taxoids -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69043758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Philosophical+transactions+of+the+Royal+Society+of+London.+Series+B%2C+Biological+sciences&rft.atitle=Induction+of+transplantation+tolerance+in+non-human+primate+preclinical+models.&rft.au=Hale%2C+Douglas+A%3BDhanireddy%2C+Kiran%3BBruno%2C+David%3BKirk%2C+Allan+D&rft.aulast=Hale&rft.aufirst=Douglas&rft.date=2005-09-29&rft.volume=360&rft.issue=1461&rft.spage=1723&rft.isbn=&rft.btitle=&rft.title=Philosophical+transactions+of+the+Royal+Society+of+London.+Series+B%2C+Biological+sciences&rft.issn=09628436&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-26 N1 - Date created - 2005-12-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Local distribution and toxicity of prolonged hippocampal infusion of muscimol. AN - 69043209; 16381190 AB - The activity of gamma-aminobutyric acid (GABA), the principal inhibitory neurotransmitter, is reduced in the hippocampus in patients with complex partial seizures from mesial temporal sclerosis. To provide preliminary safety and distribution data on using convection-enhanced delivery of agents to treat complex partial seizures and to test the efficacy and safety of regional selective neuronal suppression, the authors infused muscimol, a GABA-A receptor agonist, directly into the hippocampus of nonhuman primates using an integrated catheter electrode. Ten rhesus monkeys were divided into three groups: 1) use of catheter electrode alone (four monkeys); 2) infusion of escalating concentrations of muscimol followed by vehicle (three monkeys); and 3) infusion of vehicle and subsequent muscimol mixed with muscimol tracer (three monkeys). Infusions were begun 5 days after catheter electrode placement and continued for 5.6 days before switching to the other agent. Head magnetic resonance (MR) images and electroencephalography recordings were obtained before and during the infusions. Brain histological studies and quantitative autoradiography were performed. Neurological function was normal in controls and when muscimol concentrations were 0.125 mM or less, whereas higher concentrations (0.5 and 1 mM) produced reversible apathy and somnolence. Fluid distribution was demonstrated on MR images and muscimol distribution was demonstrated on autoradiographs throughout the hippocampus and adjacent white matter. Targeted modulation of neuronal activity is a reasonable research strategy for the investigation and treatment of medically intractable epilepsy. JF - Journal of neurosurgery AU - Heiss, John D AU - Walbridge, Stuart AU - Morrison, Paul AU - Hampton, Robert R AU - Sato, Susumu AU - Vortmeyer, Alexander AU - Butman, John A AU - O'Malley, James AU - Vidwan, Param AU - Dedrick, Robert L AU - Oldfield, Edward H AD - Surgical Neurology Branch, Electroencephalography Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1414, USA. heissj@ninds.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1035 EP - 1045 VL - 103 IS - 6 SN - 0022-3085, 0022-3085 KW - GABA Agonists KW - 0 KW - Muscimol KW - 2763-96-4 KW - Abridged Index Medicus KW - Index Medicus KW - Osmolar Concentration KW - Magnetic Resonance Imaging KW - Animals KW - Drug Administration Schedule KW - Dose-Response Relationship, Drug KW - Brain -- pathology KW - Electroencephalography KW - Macaca mulatta KW - Drug Delivery Systems -- adverse effects KW - Tissue Distribution KW - Autoradiography KW - Male KW - Female KW - Muscimol -- administration & dosage KW - Hippocampus -- physiology KW - GABA Agonists -- pharmacokinetics KW - GABA Agonists -- administration & dosage KW - Hippocampus -- metabolism KW - Muscimol -- poisoning KW - Muscimol -- pharmacokinetics KW - GABA Agonists -- poisoning KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69043209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurosurgery&rft.atitle=Local+distribution+and+toxicity+of+prolonged+hippocampal+infusion+of+muscimol.&rft.au=Heiss%2C+John+D%3BWalbridge%2C+Stuart%3BMorrison%2C+Paul%3BHampton%2C+Robert+R%3BSato%2C+Susumu%3BVortmeyer%2C+Alexander%3BButman%2C+John+A%3BO%27Malley%2C+James%3BVidwan%2C+Param%3BDedrick%2C+Robert+L%3BOldfield%2C+Edward+H&rft.aulast=Heiss&rft.aufirst=John&rft.date=2005-12-01&rft.volume=103&rft.issue=6&rft.spage=1035&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurosurgery&rft.issn=00223085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-12-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of ramosetron and granisetron for the prevention of acute and delayed emesis in Cisplatin-based chemotherapy: a randomized controlled trial. AN - 69039624; 16319109 AB - A clinical study of ramosetron was carried out to evaluate its efficacy in preventing both acute and delayed emesis in cisplatin-based chemotherapy by using a double-blind method with granisetron as the comparative drug. Cisplatin at a dose of > or =70 mg/m(2) was administered as a single intravenous (i.v.) infusion over 4 h. Patients were randomly assigned to receive either ramosetron (0.3 mg i.v. bolus 30 min before cisplatin on Day 1 and a 0.1 mg tablet in the morning for Days 2 to 5 after completion of chemotherapy; n = 36) or granisetron (3 mg i.v. infusion 30 min before cisplatin on Day 1 and a 1 mg tablet in the morning for Days 2 to 5 after completion of chemotherapy; n = 37). The observation period started with the initiation of chemotherapy (0 h) and continued for 24 h after completion of the chemotherapy for acute emesis, and on Days 2 to 5 for delayed nausea and vomiting. A total of 73 patients were eligible for evaluation, with 36 patients in the ramosetron group and 37 in the granisetron group. The efficacy of both drugs was analyzed in terms of the degree of achievement in each day of treatment. Ramosetron was as effective as granisetron in preventing nausea and vomiting (both acute and delayed emesis). The two drugs had a similar safety profile and adverse events were generally mild and transient. Ramosetron is effective and safe for the control of acute and delayed emesis induced by cisplatin. JF - Japanese journal of clinical oncology AU - Cheirsilpa, Arkom AU - Sinthusake, Tanadej AU - Songsakkaesorn, Apinya AU - Visawaprasit, Somchit AU - Chulaka, Kemachit AU - Changkuingdee, Nunchaporn AD - Division of Medical Oncology, National Cancer Institute, 268/1 Rama 6th Road, Rajthevi, Bangkok 10400, Thailand. silpa@health.moph.go.th Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 695 EP - 699 VL - 35 IS - 12 SN - 0368-2811, 0368-2811 KW - Antiemetics KW - 0 KW - Benzimidazoles KW - ramosetron KW - 7ZRO0SC54Y KW - Cisplatin KW - Q20Q21Q62J KW - Granisetron KW - WZG3J2MCOL KW - Index Medicus KW - Dizziness -- chemically induced KW - Neoplasms -- drug therapy KW - Drug Administration Schedule KW - Double-Blind Method KW - Endpoint Determination KW - Humans KW - Aged KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Headache -- chemically induced KW - Aged, 80 and over KW - Adult KW - Middle Aged KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Male KW - Female KW - Granisetron -- adverse effects KW - Antiemetics -- therapeutic use KW - Granisetron -- therapeutic use KW - Nausea -- prevention & control KW - Benzimidazoles -- adverse effects KW - Vomiting, Anticipatory -- prevention & control KW - Benzimidazoles -- therapeutic use KW - Cisplatin -- adverse effects KW - Antiemetics -- adverse effects KW - Cisplatin -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69039624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Japanese+journal+of+clinical+oncology&rft.atitle=Comparison+of+ramosetron+and+granisetron+for+the+prevention+of+acute+and+delayed+emesis+in+Cisplatin-based+chemotherapy%3A+a+randomized+controlled+trial.&rft.au=Cheirsilpa%2C+Arkom%3BSinthusake%2C+Tanadej%3BSongsakkaesorn%2C+Apinya%3BVisawaprasit%2C+Somchit%3BChulaka%2C+Kemachit%3BChangkuingdee%2C+Nunchaporn&rft.aulast=Cheirsilpa&rft.aufirst=Arkom&rft.date=2005-12-01&rft.volume=35&rft.issue=12&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=Japanese+journal+of+clinical+oncology&rft.issn=03682811&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-03 N1 - Date created - 2005-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reproductive outcomes in men with prenatal exposure to diethylstilbestrol. AN - 68904275; 16359959 AB - To examine prenatal diethylstilbestrol (DES) exposure in relation to male reproductive outcomes. Prospective observational study. Participants were identified through record review, clinical trial participation, or an obstetrics clinic. A total of 1,085 DES-exposed and 1,047 unexposed men. Participants were exposed prenatally to DES through the mother's obstetrics care or clinical trial participation. Infertility; never fathering a pregnancy or live birth; number of pregnancies or live births fathered. We found little evidence that prenatal DES exposure affects the likelihood of never fathering a pregnancy or live birth, or influences the mean number of fathered pregnancies or live births. Our data suggest that DES-exposed men are slightly more likely to experience infertility (relative risk [RR] = 1.3, 95% confidence interval [CI] = 1.0-1.6). The DES dose and gestational timing did not influence infertility or the number of pregnancies or live births fathered, but results were inconsistent for dose effects on the likelihood of never fathering a pregnancy or a live birth. Prenatal DES exposure may be associated with a slightly increased risk of having an infertility experience, but does not increase the likelihood of never fathering a pregnancy or a live birth, or the number of pregnancies or live births fathered. JF - Fertility and sterility AU - Perez, Kimberly M AU - Titus-Ernstoff, Linda AU - Hatch, Elizabeth E AU - Troisi, Rebecca AU - Wactawski-Wende, Jean AU - Palmer, Julie R AU - Noller, Kenneth AU - Hoover, Robert N AU - National Cancer Institute's DES Follow-up Study Group AD - Department of Social and Preventive Medicine, University of Buffalo, State of New York, Buffalo, New York, USA. ; National Cancer Institute's DES Follow-up Study Group Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1649 EP - 1656 VL - 84 IS - 6 KW - Estrogens, Non-Steroidal KW - 0 KW - Diethylstilbestrol KW - 731DCA35BT KW - Index Medicus KW - Prospective Studies KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Interviews as Topic KW - Middle Aged KW - Follow-Up Studies KW - Adolescent KW - Male KW - Female KW - Pregnancy KW - Age Distribution KW - Diethylstilbestrol -- adverse effects KW - Pregnancy Outcome -- epidemiology KW - Prenatal Exposure Delayed Effects -- epidemiology KW - Infertility, Male -- chemically induced KW - Estrogens, Non-Steroidal -- administration & dosage KW - Diethylstilbestrol -- administration & dosage KW - Infertility, Male -- epidemiology KW - Estrogens, Non-Steroidal -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68904275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fertility+and+sterility&rft.atitle=Reproductive+outcomes+in+men+with+prenatal+exposure+to+diethylstilbestrol.&rft.au=Perez%2C+Kimberly+M%3BTitus-Ernstoff%2C+Linda%3BHatch%2C+Elizabeth+E%3BTroisi%2C+Rebecca%3BWactawski-Wende%2C+Jean%3BPalmer%2C+Julie+R%3BNoller%2C+Kenneth%3BHoover%2C+Robert+N%3BNational+Cancer+Institute%27s+DES+Follow-up+Study+Group&rft.aulast=Perez&rft.aufirst=Kimberly&rft.date=2005-12-01&rft.volume=84&rft.issue=6&rft.spage=1649&rft.isbn=&rft.btitle=&rft.title=Fertility+and+sterility&rft.issn=1556-5653&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-08 N1 - Date created - 2005-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Science and society: the Long Island Breast Cancer Study Project. AN - 68885594; 16341086 AB - In the early 1990s, breast cancer advocates petitioned the United States Congress to investigate the high rates of breast cancer on Long Island in the state of New York. The resulting law led to the Long Island Breast Cancer Study Project (LIBCSP)--more than ten research projects designed to study the possible causes of this increased incidence of cancer. This project reported that there was no evidence that environmental exposures were responsible. Controversial from its start, the LIBCSP has had an important role in efforts to understand the reasons for the high rates of breast cancer in some regions of the United States. JF - Nature reviews. Cancer AU - Winn, Deborah M AD - Clinical and Genetic Epidemiology Research Branch, Division of Cancer Control and Population Sciences, Executive Plaza North, Room 5134, MSC 7393, 6130 Executive Boulevard, Bethesda, Maryland 20892-7393, USA. winnde@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 986 EP - 994 VL - 5 IS - 12 SN - 1474-175X, 1474-175X KW - Index Medicus KW - Risk Factors KW - Humans KW - Cohort Studies KW - New York -- epidemiology KW - Cluster Analysis KW - Female KW - Breast Neoplasms -- mortality KW - Environmental Exposure KW - Breast Neoplasms -- etiology KW - Breast Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68885594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+reviews.+Cancer&rft.atitle=Science+and+society%3A+the+Long+Island+Breast+Cancer+Study+Project.&rft.au=Winn%2C+Deborah+M&rft.aulast=Winn&rft.aufirst=Deborah&rft.date=2005-12-01&rft.volume=5&rft.issue=12&rft.spage=986&rft.isbn=&rft.btitle=&rft.title=Nature+reviews.+Cancer&rft.issn=1474175X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-16 N1 - Date created - 2005-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Secondary ion mass spectroscopy demonstrates retention of beryllium in chronic beryllium disease granulomas. AN - 68885496; 16340702 AB - We hypothesized that beryllium (Be) might persist in lung granulomas in patients with chronic beryllium disease (CBD). A total of 33 Be-exposed ceramics workers underwent transbronchial biopsy. They were classified based on histopathology and Be-lymphocyte proliferation test as CBD or other categories. Lung tissue sections were analyzed using secondary ion mass spectroscopy. Be was detected in the lungs of all Be-exposed groups. Be levels were increased within the granulomas of patients with CBD compared with the Be levels outside granulomas. Notably, Be was detectable in the lungs of CBD patients who had ceased exposure to Be an average of 9 years previously. Be was detected in the lungs of all Be-exposed subjects, with the highest levels of persistent Be inside CBD lung granulomas. Be antigen persistence may help explain the chronicity of this granulomatous disorder. JF - Journal of occupational and environmental medicine AU - Sawyer, Richard T AU - Abraham, Jerrold L AU - Daniloff, Elaine AU - Newman, Lee S AD - Division of Environmental and Occupational Health Sciences, Robert Hollis Laboratory of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA. sawyerr@niaid.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1218 EP - 1226 VL - 47 IS - 12 SN - 1076-2752, 1076-2752 KW - Beryllium KW - OW5102UV6N KW - Index Medicus KW - Occupational Exposure KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Chronic Disease KW - Biopsy KW - Male KW - Female KW - Berylliosis KW - Spectrometry, Mass, Secondary Ion -- methods KW - Granuloma, Respiratory Tract KW - Beryllium -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68885496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=LRP+1+B+functions+as+a+receptor+for+Pseudomonas+exotoxin.&rft.au=Pastrana%2C+Diana+V%3BHanson%2C+Alison+J%3BKnisely%2C+Jane%3BBu%2C+Guojun%3BFitzgerald%2C+David+J&rft.aulast=Pastrana&rft.aufirst=Diana&rft.date=2005-09-25&rft.volume=1741&rft.issue=3&rft.spage=234&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-14 N1 - Date created - 2005-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A pilot study of an investigational testosterone transdermal patch system in young women with spontaneous premature ovarian failure. AN - 68873895; 16174721 AB - Evidence suggests that young women with spontaneous premature ovarian failure (sPOF) have significantly lower androgen levels than age-matched regularly menstruating women. The objective of the study was to evaluate an investigational testosterone transdermal patch (TTP) designed to deliver the normal ovarian production rate of testosterone. This was an open-label study (2-month baseline period followed by 2-month treatment period). Nine women with sPOF and a history of regular bleeding patterns on standard estrogen/progestogen cyclic treatment participated in the study. One subject with abnormal baseline levels was excluded. Four consecutive 28-d cycles of transdermal estradiol (E2; 0.1 mg/d) and sequential oral medroxyprogesterone acetate (MPA; 10 mg/d for the last 12 d of each cycle). During cycles 3 and 4, an investigational TTP (nominal delivery 150 microg/d) was applied twice weekly to the abdomen. Steady-state pharmacokinetic profiles of free and total testosterone and scheduled vaginal bleeding patterns were studied. The mean (95% confidence interval) of the time-average free testosterone levels during TTP treatment was 7.5 (4.9-9.9) pg/ml; 26.0 (17.2-34.6) pmol/liter (with E2), and 6.9 (4.9-8.8) pg/ml; 23.9 (17.2-30.5) pmol/liter (with E2 and MPA). The confidence intervals of the means include the upper limit of normal for premenopausal women, i.e. 6.8 pg/ml (23.5 pmol/liter), although the mean values are slightly above this. The addition of TTP to cyclic E2/MPA therapy in women with sPOF produced mean free testosterone levels that approximate the upper limit of normal. A 3-yr study to assess safety and effectiveness in this population is in progress. JF - The Journal of clinical endocrinology and metabolism AU - Kalantaridou, Sophia N AU - Calis, Karim A AU - Mazer, Norman A AU - Godoy, Heidy AU - Nelson, Lawrence M AD - Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 6549 EP - 6552 VL - 90 IS - 12 SN - 0021-972X, 0021-972X KW - Androgens KW - 0 KW - Hormones KW - Testosterone KW - 3XMK78S47O KW - Abridged Index Medicus KW - Index Medicus KW - Administration, Cutaneous KW - Humans KW - Adult KW - Hormones -- blood KW - Pilot Projects KW - Menstrual Cycle -- drug effects KW - Female KW - Androgens -- therapeutic use KW - Testosterone -- therapeutic use KW - Testosterone -- administration & dosage KW - Primary Ovarian Insufficiency -- physiopathology KW - Primary Ovarian Insufficiency -- blood KW - Androgens -- adverse effects KW - Testosterone -- adverse effects KW - Primary Ovarian Insufficiency -- drug therapy KW - Androgens -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68873895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+endocrinology+and+metabolism&rft.atitle=A+pilot+study+of+an+investigational+testosterone+transdermal+patch+system+in+young+women+with+spontaneous+premature+ovarian+failure.&rft.au=Kalantaridou%2C+Sophia+N%3BCalis%2C+Karim+A%3BMazer%2C+Norman+A%3BGodoy%2C+Heidy%3BNelson%2C+Lawrence+M&rft.aulast=Kalantaridou&rft.aufirst=Sophia&rft.date=2005-12-01&rft.volume=90&rft.issue=12&rft.spage=6549&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+endocrinology+and+metabolism&rft.issn=0021972X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Research opportunities on alcohol and liver damage. AN - 68868252; 16317668 JF - Hepatology (Baltimore, Md.) AU - Zakhari, Samir AU - Hoofnagle, Jay H AD - Division of Metabolism and Health Effects NIAAA, National Institutes of Health Bethesda, MD, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1243 VL - 42 IS - 6 SN - 0270-9139, 0270-9139 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - United States KW - Animals KW - Humans KW - National Institute of Mental Health (U.S.) KW - Research KW - Liver -- drug effects KW - Ethanol -- toxicity KW - Ethanol -- metabolism KW - Liver Diseases, Alcoholic -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68868252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Research+opportunities+on+alcohol+and+liver+damage.&rft.au=Zakhari%2C+Samir%3BHoofnagle%2C+Jay+H&rft.aulast=Zakhari&rft.aufirst=Samir&rft.date=2005-12-01&rft.volume=42&rft.issue=6&rft.spage=1243&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-22 N1 - Date created - 2005-12-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hepatitis C virus load and survival among injection drug users in the United States. AN - 68867246; 16317675 AB - Persons chronically infected with hepatitis C virus (HCV), some of whom may be coinfected with HIV and human T-lymphotropic virus type II (HTLV-II), are at high risk for end-stage liver disease (ESLD). We evaluated whether ESLD death was associated with premorbid HCV RNA level or specific HCV protein antibodies among persons with or without HIV/HTLV-II coinfection in a cohort of 6,570 injection drug users who enrolled in 9 US cities between 1987 and 1991. We compared 84 ESLD descendents and 305 randomly selected cohort participants with detectable HCV RNA, stratified by sex, race, HIV, and HTLV-II strata. Relative hazard (RH) of ESLD death was derived from the proportional hazard model. Risk of ESLD death was unrelated to the intensity of antibodies against the HCV c-22(p), c-33(p), c-100(p), and NS5 proteins, individually or combined, but it increased with HCV RNA level (RH(adj) = 2.26 per log(10) IU/mL, 95% CI: 1.45-5.92). The association between HCV RNA level and ESLD death remained significant after adjustment for alcohol consumption (RH(adj) = 2.57 per log(10) IU/mL, 95% CI: 1.50-8.10). Deaths from AIDS (n = 45) and other causes (n = 43) were unrelated to HCV RNA (RH(adj)= 1.14 and 1.29 per log(10) IU/mL, respectively). HIV infection was not associated with ESLD risk in multivariate analyses adjusted for HCV RNA. Men had an increased risk of ESLD death in unadjusted analyses (RH = 1.92, 95% CI: 1.15-3.56) but not in multivariate analysis (RH(adj) = 0.98, 95% CI: 0.48-2.88). Non-black patients were at increased risk for ESLD death (RH(adj)= 2.76, 95% CI: 1.49-10.09). In conclusion, HCV RNA level is a predictor of ESLD death among persons with chronic HCV infection. JF - Hepatology (Baltimore, Md.) AU - Hisada, Michie AU - Chatterjee, Nilanjan AU - Kalaylioglu, Zeynep AU - Battjes, Robert J AU - Goedert, James J AD - Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA. hisadam@exchange.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1446 EP - 1452 VL - 42 IS - 6 SN - 0270-9139, 0270-9139 KW - RNA, Viral KW - 0 KW - Index Medicus KW - HIV Infections -- virology KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - RNA, Viral -- blood KW - Viral Load KW - Substance Abuse, Intravenous -- virology KW - Hepacivirus -- isolation & purification KW - Hepatitis C, Chronic -- virology KW - Substance Abuse, Intravenous -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68867246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Hepatitis+C+virus+load+and+survival+among+injection+drug+users+in+the+United+States.&rft.au=Hisada%2C+Michie%3BChatterjee%2C+Nilanjan%3BKalaylioglu%2C+Zeynep%3BBattjes%2C+Robert+J%3BGoedert%2C+James+J&rft.aulast=Hisada&rft.aufirst=Michie&rft.date=2005-12-01&rft.volume=42&rft.issue=6&rft.spage=1446&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-22 N1 - Date created - 2005-12-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Hepatology. 2005 Dec;42(6):1261-3 [16317702] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Topiramate in chronic lumbar radicular pain. AN - 68863905; 16326371 AB - Chronic lumbar radicular pain is the most common neuropathic pain syndrome. This was a double-blind, randomized, 2-period crossover trial of topiramate (50 to 400 mg) and diphenhydramine (6.25 to 50 mg) as active placebo to assess the efficacy of topiramate. Each period consisted of a 4-week escalation, a 2-week maintenance at the highest tolerated dose, and a 2-week taper. Main outcome was the mean daily leg pain score on a 0 to 10 scale during the maintenance period. Global pain relief was assessed on a 6-level category scale. In the 29 of 42 patients who completed the study, topiramate reduced leg pain by a mean of 19% (P = .065). Global pain relief scores were significantly better on topiramate (P < .005). Mean doses were topiramate 200 mg and diphenhydramine 40 mg. We concluded that topiramate treatment might reduce chronic sciatica in some patients but causes frequent side effects and dropouts. We would not recommend topiramate unless studies of alternative regimens showed a better therapeutic ratio. The anticonvulsant topiramate might reduce chronic lumbar nerve root pain through effects such as blockade of voltage-gated sodium channels and AMPA/kainite glutamate receptors, modulation of voltage-gated calcium channels, and gamma-aminobutyric acid agonist-like effects. JF - The journal of pain : official journal of the American Pain Society AU - Khoromi, Suzan AU - Patsalides, Athos AU - Parada, Suzan AU - Salehi, Vesta AU - Meegan, Jennifer M AU - Max, Mitchell B AD - Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892-1302, USA. khoromisu@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 829 EP - 836 VL - 6 IS - 12 SN - 1526-5900, 1526-5900 KW - Analgesics KW - 0 KW - Anticonvulsants KW - Ion Channels KW - Placebos KW - Receptors, Glutamate KW - topiramate KW - 0H73WJJ391 KW - Fructose KW - 30237-26-4 KW - Diphenhydramine KW - 8GTS82S83M KW - Index Medicus KW - Drug Administration Schedule KW - Double-Blind Method KW - Dose-Response Relationship, Drug KW - Receptors, Glutamate -- drug effects KW - Humans KW - Ion Channels -- drug effects KW - Anticonvulsants -- adverse effects KW - Aged KW - Anticonvulsants -- administration & dosage KW - Analgesics -- adverse effects KW - Patient Compliance -- statistics & numerical data KW - Diphenhydramine -- pharmacology KW - Adult KW - Treatment Outcome KW - Cross-Over Studies KW - Middle Aged KW - Chronic Disease KW - Analgesics -- administration & dosage KW - Male KW - Female KW - Low Back Pain -- drug therapy KW - Fructose -- analogs & derivatives KW - Intervertebral Disc Displacement -- physiopathology KW - Radiculopathy -- physiopathology KW - Fructose -- adverse effects KW - Low Back Pain -- physiopathology KW - Low Back Pain -- etiology KW - Fructose -- administration & dosage KW - Radiculopathy -- drug therapy KW - Intervertebral Disc Displacement -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68863905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+journal+of+pain+%3A+official+journal+of+the+American+Pain+Society&rft.atitle=Topiramate+in+chronic+lumbar+radicular+pain.&rft.au=Khoromi%2C+Suzan%3BPatsalides%2C+Athos%3BParada%2C+Suzan%3BSalehi%2C+Vesta%3BMeegan%2C+Jennifer+M%3BMax%2C+Mitchell+B&rft.aulast=Khoromi&rft.aufirst=Suzan&rft.date=2005-12-01&rft.volume=6&rft.issue=12&rft.spage=829&rft.isbn=&rft.btitle=&rft.title=The+journal+of+pain+%3A+official+journal+of+the+American+Pain+Society&rft.issn=15265900&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-24 N1 - Date created - 2005-12-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gateway vectors for the production of combinatorially-tagged His6-MBP fusion proteins in the cytoplasm and periplasm of Escherichia coli. AN - 68860336; 16322578 AB - Many proteins that accumulate in the form of insoluble aggregates when they are overproduced in Escherichia coli can be rendered soluble by fusing them to E. coli maltose binding protein (MBP), and this will often enable them to fold in to their biologically active conformations. Yet, although it is an excellent solubility enhancer, MBP is not a particularly good affinity tag for protein purification. To compensate for this shortcoming, we have engineered and successfully tested Gateway destination vectors for the production of dual His6MBP-tagged fusion proteins in the cytoplasm and periplasm of E. coli. The MBP moiety improves the yield and solubility of its fusion partners while the hexahistidine tag (His-tag) serves to facilitate their purification. The availability of a vector that targets His6MBP fusion proteins to the periplasm expands the utility of this dual tagging approach to include proteins that contain disulfide bonds or are toxic in the bacterial cytoplasm. JF - Protein science : a publication of the Protein Society AU - Nallamsetty, Sreedevi AU - Austin, Brian P AU - Penrose, Kerri J AU - Waugh, David S AD - National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 2964 EP - 2971 VL - 14 IS - 12 SN - 0961-8368, 0961-8368 KW - Carrier Proteins KW - 0 KW - His-His-His-His-His-His KW - Maltose-Binding Proteins KW - Oligopeptides KW - Recombinant Fusion Proteins KW - Histidine KW - 4QD397987E KW - Ribonucleases KW - EC 3.1.- KW - Index Medicus KW - Recombinant Fusion Proteins -- metabolism KW - Base Sequence KW - Solubility KW - Ribonucleases -- isolation & purification KW - Ribonucleases -- genetics KW - Recombinant Fusion Proteins -- isolation & purification KW - Recombinant Fusion Proteins -- genetics KW - Molecular Sequence Data KW - Gene Expression KW - Ribonucleases -- chemistry KW - Amino Acid Sequence KW - Genetic Vectors -- genetics KW - Ribonucleases -- metabolism KW - Escherichia coli -- metabolism KW - Carrier Proteins -- metabolism KW - Cytoplasm -- metabolism KW - Histidine -- genetics KW - Escherichia coli -- cytology KW - Carrier Proteins -- genetics KW - Periplasm -- metabolism KW - Oligopeptides -- genetics KW - Oligopeptides -- metabolism KW - Escherichia coli -- genetics KW - Histidine -- metabolism KW - Carrier Proteins -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68860336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+International+Meeting+of+the+European+Society+of+Gynaecological+Oncology+%28ESGO+14%29&rft.atitle=Age+and+Results+of+Treatment+of+Atypical+Glandular+Cells&rft.au=Figueiredo%2C+E.M.A.%3BGiorgi%2C+R%3BMagalhaes%2C+C.M.G.%3BMoralez%2C+G+M&rft.aulast=Figueiredo&rft.aufirst=E.M.A.&rft.date=2005-09-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+International+Meeting+of+the+European+Society+of+Gynaecological+Oncology+%28ESGO+14%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-03 N1 - Date created - 2005-12-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Biochem. 2000 Jan;267(2):566-72 [10632727] Trends Biotechnol. 2005 Jun;23(6):316-20 [15922084] Structure. 2000 Sep 15;8(9):R177-85 [10986469] Protein Eng. 2001 Apr;14(4):297-305 [11391022] Toxicon. 2001 Oct;39(10):1595-600 [11478968] J Mol Biol. 2001 Sep 7;312(1):79-93 [11545587] Protein Sci. 2002 Feb;11(2):313-21 [11790841] Protein Eng. 2001 Dec;14(12):993-1000 [11809930] Acta Crystallogr D Biol Crystallogr. 2002 Mar;58(Pt 3):398-406 [11856824] Cancer Lett. 2005 Jul 28;225(2):225-36 [15978327] Methods Mol Biol. 2007;363:1-19 [17272834] Eur J Biochem. 2002 Apr;269(7):1854-65 [11952787] Protein Sci. 2002 Jul;11(7):1714-9 [12070324] Methods Mol Biol. 2003;205:99-117 [12491882] FEBS Lett. 2003 Feb 27;537(1-3):53-7 [12606030] J Struct Funct Genomics. 2002;2(2):83-92 [12836665] Biochemistry. 2003 Nov 18;42(45):13202-11 [14609331] Protein Expr Purif. 2003 Dec;32(2):194-201 [14965764] Curr Opin Struct Biol. 2004 Oct;14(5):577-83 [15465318] Protein Expr Purif. 2004 Nov;38(1):108-15 [15477088] J Bacteriol. 1967 Dec;94(6):1934-45 [4294595] Gene. 1983 Nov;25(2-3):167-78 [6363212] Protein Eng. 1995 Mar;8(3):261-73 [7479688] Protein Expr Purif. 1997 Aug;10(3):309-19 [9268677] Protein Sci. 1999 Aug;8(8):1668-74 [10452611] Mol Biotechnol. 2000 May;15(1):51-63 [10911622] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyte-associated antigen 4 blockade and interleukin 2: a phase I/II study. AN - 68852939; 16283570 AB - Cytotoxic T lymphocyte-associated antigen (CTLA)-4 can inhibit T-cell responses and is involved in tolerance against self antigens. We previously reported autoimmune manifestations and objective cancer regressions in patients with metastatic melanoma treated with CTLA-4 blockade. The possibility of activating tumor-reactive T cells while removing inhibitory activity with CTLA-4 blockade has stimulated interest in using anti-CTLA-4 antibodies in combination with other cancer immunotherapies to improve clinical outcomes. In this study, we assessed the antitumor activity and autoimmune toxicity of CTLA-4 blockade in combination with an immune-activating stimulus, interleukin (IL)-2, in patients with metastatic melanoma. Thirty-six patients received anti-CTLA-4 antibody every 3 weeks. Three patients per cohort received doses of .1, .3, 1.0, and 2.0 mg/kg. Twenty-four patients received 3.0 mg/kg. All patients received IL-2 therapy (720,000 IU/kg every 8 hours to a maximum of 15 doses). Eight patients (22%) experienced objective tumor responses (three complete and five partial), including metastases in the lungs, lymph nodes, mediastinum, and subcutaneous tissues. Six of the eight patients have ongoing objective responses at 11 to 19 months. Five patients (14%) developed grade III/IV autoimmune toxicities secondary to anti-CTLA-4 administration, including four patients with enterocolitis and one with arthritis and uveitis. There is not evidence to support a synergistic effect of CTLA-4 blockade plus IL-2 administration, because the 22% objective response rate is that expected from the sum of these two agents administered alone. Durable cancer regressions were seen in patients treated with this combination. JF - Annals of surgical oncology AU - Maker, Ajay V AU - Phan, Giao Q AU - Attia, Peter AU - Yang, James C AU - Sherry, Richard M AU - Topalian, Suzanne L AU - Kammula, Udai S AU - Royal, Richard E AU - Haworth, Leah R AU - Levy, Catherine AU - Kleiner, David AU - Mavroukakis, Sharon A AU - Yellin, Michael AU - Rosenberg, Steven A AD - Surgery Branch, National Cancer Institute, National Institutes of Health, CRC Room 3-3940, 10 Center Drive, MSC 1201, Bethesda, MD 20814, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1005 EP - 1016 VL - 12 IS - 12 SN - 1068-9265, 1068-9265 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, CD KW - Antigens, Differentiation KW - CTLA-4 Antigen KW - CTLA4 protein, human KW - Immunosuppressive Agents KW - Interleukin-2 KW - ipilimumab KW - 6T8C155666 KW - Index Medicus KW - Drug Therapy, Combination KW - Humans KW - Adult KW - Tomography, X-Ray Computed KW - Autoimmunity KW - Middle Aged KW - Flow Cytometry KW - Male KW - Female KW - Melanoma -- diagnostic imaging KW - Skin Neoplasms -- immunology KW - Melanoma -- secondary KW - Antigens, Differentiation -- therapeutic use KW - Melanoma -- immunology KW - Skin Neoplasms -- secondary KW - Antibodies, Monoclonal -- therapeutic use KW - Immunotherapy -- methods KW - Skin Neoplasms -- drug therapy KW - Antibodies, Monoclonal -- pharmacokinetics KW - Interleukin-2 -- therapeutic use KW - Melanoma -- drug therapy KW - Skin Neoplasms -- diagnostic imaging KW - Immunosuppressive Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68852939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+surgical+oncology&rft.atitle=Tumor+regression+and+autoimmunity+in+patients+treated+with+cytotoxic+T+lymphocyte-associated+antigen+4+blockade+and+interleukin+2%3A+a+phase+I%2FII+study.&rft.au=Maker%2C+Ajay+V%3BPhan%2C+Giao+Q%3BAttia%2C+Peter%3BYang%2C+James+C%3BSherry%2C+Richard+M%3BTopalian%2C+Suzanne+L%3BKammula%2C+Udai+S%3BRoyal%2C+Richard+E%3BHaworth%2C+Leah+R%3BLevy%2C+Catherine%3BKleiner%2C+David%3BMavroukakis%2C+Sharon+A%3BYellin%2C+Michael%3BRosenberg%2C+Steven+A&rft.aulast=Maker&rft.aufirst=Ajay&rft.date=2005-12-01&rft.volume=12&rft.issue=12&rft.spage=1005&rft.isbn=&rft.btitle=&rft.title=Annals+of+surgical+oncology&rft.issn=10689265&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-09 N1 - Date created - 2005-12-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunother. 2001 Jul-Aug;24(4):287-93 [11565830] Nat Immunol. 2002 Jul;3(7):611-8 [12087419] Annu Rev Immunol. 1996;14:233-58 [8717514] J Exp Med. 1996 Jun 1;183(6):2541-50 [8676075] J Exp Med. 1996 Jun 1;183(6):2533-40 [8676074] Science. 1996 Mar 22;271(5256):1734-6 [8596936] Science. 1995 Nov 10;270(5238):985-8 [7481803] J Immunol. 1993 Oct 1;151(7):3489-99 [8397258] J Immunol. 1992 Jul 15;149(2):380-8 [1320641] J Exp Med. 1991 Sep 1;174(3):561-9 [1714933] Science. 1990 Jun 15;248(4961):1349-56 [2113314] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8372-7 [12826605] J Immunol. 1996 Aug 15;157(4):1333-6 [8759711] J Neuroimmunol. 1997 Mar;73(1-2):57-62 [9058759] Immunity. 1997 Oct;7(4):445-50 [9354465] J Exp Med. 1998 Feb 2;187(3):427-32 [9449722] Ann Surg. 1998 Sep;228(3):307-19 [9742914] J Exp Med. 2000 Jul 17;192(2):303-10 [10899917] J Exp Med. 2000 Jul 17;192(2):295-302 [10899916] Cancer Res. 2000 May 1;60(9):2444-8 [10811122] J Clin Oncol. 1999 Jul;17(7):2105-16 [10561265] J Clin Oncol. 2005 Sep 1;23(25):6043-53 [16087944] Eur J Immunol. 2004 Dec;34(12):3485-96 [15484187] J Exp Med. 1999 Aug 2;190(3):355-66 [10430624] J Immunol. 1999 May 15;162(10):5813-20 [10229815] Comment In: Ann Surg Oncol. 2005 Dec;12(12):957-9 [16244797] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tenofovir disoproxil fumarate and an optimized background regimen of antiretroviral agents as salvage therapy for pediatric HIV infection. AN - 68848556; 16291735 AB - Highly active antiretroviral therapy has altered the course of HIV infection among children, but new antiretroviral agents are needed for treatment-experienced children with drug-resistant virus. Tenofovir disoproxil fumarate (DF) is a promising agent for use in pediatric salvage therapy, because of its tolerability, efficacy, and resistance profile. We designed this study to provide preliminary pediatric safety and dosing information on tenofovir DF, while also providing potentially efficacious salvage therapy for heavily treatment-experienced, HIV-infected children. Tenofovir DF, alone and in combination with optimized background antiretroviral regimens, was studied among 18 HIV-infected children (age range: 8.3-16.2 years) who had progressive disease with > or = 2 prior antiretroviral regimens, in a single-center, open-label trial. Tenofovir DF monotherapy for 6 days was followed by the addition of individualized antiretroviral regimens. Subjects were monitored with HIV RNA reverse transcription-polymerase chain reaction, flow cytometry, and routine laboratory studies; monitoring for bone toxicity included measurement of lumbar spine bone mineral density (BMD) with dual-energy x-ray absorptiometry. Subjects were monitored through 48 weeks. Two subjects developed grade 3 elevated hepatic transaminase levels during monotherapy and were removed from the study. The remaining 16 subjects had a median of 4 antiretroviral agents (range: 3-5 agents) added to tenofovir DF. HIV plasma RNA levels decreased from a median pretreatment level of 5.4 log10 copies per mL (range: 4.1-5.9 log10 copies per mL) to 4.21 log10 copies per mL at week 48 (n = 15), with 6 subjects having 6% decrease in BMD for 5 of 15 subjects evaluated at week 48, necessitating the discontinuation of tenofovir DF therapy for 2; all 5 subjects experienced >2 log10 copies per mL decreases in HIV plasma RNA levels. Tenofovir DF-containing, individualized, highly active antiretroviral therapy regimens were well tolerated and effective among heavily treatment-experienced, HIV-infected children. Loss of BMD may limit tenofovir DF use among prepubertal patients. JF - Pediatrics AU - Hazra, Rohan AU - Gafni, Rachel I AU - Maldarelli, Frank AU - Balis, Frank M AU - Tullio, Antonella N AU - DeCarlo, Ellen AU - Worrell, Carol J AU - Steinberg, Seth M AU - Flaherty, John AU - Yale, Kitty AU - Kearney, Brian P AU - Zeichner, Steven L AD - HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - e846 EP - e854 VL - 116 IS - 6 KW - Anti-HIV Agents KW - 0 KW - Organophosphonates KW - Tenofovir KW - 99YXE507IL KW - Adenine KW - JAC85A2161 KW - Abridged Index Medicus KW - Index Medicus KW - Viral Load KW - Drug Resistance, Viral KW - Humans KW - Salvage Therapy KW - Antiretroviral Therapy, Highly Active KW - Child KW - CD4 Lymphocyte Count KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Adenine -- therapeutic use KW - Organophosphonates -- therapeutic use KW - Anti-HIV Agents -- therapeutic use KW - HIV Infections -- drug therapy KW - Adenine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68848556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Tenofovir+disoproxil+fumarate+and+an+optimized+background+regimen+of+antiretroviral+agents+as+salvage+therapy+for+pediatric+HIV+infection.&rft.au=Hazra%2C+Rohan%3BGafni%2C+Rachel+I%3BMaldarelli%2C+Frank%3BBalis%2C+Frank+M%3BTullio%2C+Antonella+N%3BDeCarlo%2C+Ellen%3BWorrell%2C+Carol+J%3BSteinberg%2C+Seth+M%3BFlaherty%2C+John%3BYale%2C+Kitty%3BKearney%2C+Brian+P%3BZeichner%2C+Steven+L&rft.aulast=Hazra&rft.aufirst=Rohan&rft.date=2005-12-01&rft.volume=116&rft.issue=6&rft.spage=e846&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=1098-4275&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-22 N1 - Date created - 2005-12-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hematopoietic stem cell gene therapy: dead or alive? AN - 68847047; 16216357 AB - Despite some reports of toxicity in recent clinical trials, many scientists believe that the use of gene therapy in the treatment of congenital genetic defects and acquired disorders has too much potential to abandon. Hematopoietic stem cells (HSCs) have been primary targets for gene therapy owing to their capacity for differentiation and self-renewal, whereby multiple cell lineages can potentially be corrected for the lifetime of an individual. These efforts represent a long-term investment towards broadening physicians' treatment options for patients whose diseases, in particular certain immunodeficiencies, are fatal and where no other therapy is available. We review the recent progress and clinical triumphs as well as the reported toxicity related to insertional mutagenesis. We also discuss the current risk-to-benefit estimates and future strategies to reduce the risks and allow full realization of clinical potential. Scientists are continually revising protocols: going both from "bench to bedside" and, as strikingly demonstrated by HSC gene therapy, from "bedside to bench." JF - Trends in biotechnology AU - Ferguson, Cole AU - Larochelle, Andre AU - Dunbar, Cynthia E AD - Molecular Hematopoiesis Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 589 EP - 597 VL - 23 IS - 12 SN - 0167-7799, 0167-7799 KW - Index Medicus KW - Animals KW - Severe Combined Immunodeficiency -- therapy KW - Gene Transfer Techniques KW - Humans KW - Clinical Trials as Topic KW - Disease Models, Animal KW - Forecasting KW - Severe Combined Immunodeficiency -- genetics KW - Mutagenesis, Insertional KW - Hematopoietic Stem Cells KW - Genetic Therapy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68847047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+biotechnology&rft.atitle=Hematopoietic+stem+cell+gene+therapy%3A+dead+or+alive%3F&rft.au=Ferguson%2C+Cole%3BLarochelle%2C+Andre%3BDunbar%2C+Cynthia+E&rft.aulast=Ferguson&rft.aufirst=Cole&rft.date=2005-12-01&rft.volume=23&rft.issue=12&rft.spage=589&rft.isbn=&rft.btitle=&rft.title=Trends+in+biotechnology&rft.issn=01677799&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-18 N1 - Date created - 2005-11-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Can experimental paradigms and animal models be used to discover clinically effective medications for alcoholism? AN - 68843169; 16318951 AB - Evaluating medications in animal laboratory paradigms can reveal whether the compound is effective in an established alcoholism model, at clinically relevant doses and exposure conditions, when administered orally (or transdermally) and without serious limiting side effects. Positive outcomes constitute a possible discovery for relevance to alcoholism and, under favorable marketing conditions, encourage further development. Medication testing using animal models of alcoholism might also guide clinical testing by discriminating clinically effective from clinically ineffective compounds. This ability rests on whether there are tests or, more reasonably, batteries of tests having this discriminative ability. The present paper examines this possibility. Effects of naltrexone and acamprosate in animal paradigms which model behavioral aspects of alcoholism are reviewed and compared with the effects of compounds which have limited effects in alcoholics. It is not clear at present whether any single paradigm or combination of paradigms differentiates clinically effective from clinically limited compounds. Steps are suggested to improve the use of preclinical laboratory tests to predict which compounds are likely to be effective medications for reducing drinking and sustaining abstinence in human alcoholics. JF - Addiction biology AU - Egli, Mark AD - Division of Neuroscience and Behavior, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services Bethesda, MD 20892-9304, USA. megli@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 309 EP - 319 VL - 10 IS - 4 SN - 1355-6215, 1355-6215 KW - Alcohol Deterrents KW - 0 KW - Taurine KW - 1EQV5MLY3D KW - Naltrexone KW - 5S6W795CQM KW - acamprosate KW - N4K14YGM3J KW - Index Medicus KW - Taurine -- analogs & derivatives KW - Naltrexone -- administration & dosage KW - Animals KW - Taurine -- toxicity KW - Humans KW - Clinical Trials as Topic KW - Taurine -- administration & dosage KW - Rodentia KW - Drug Evaluation, Preclinical KW - Naltrexone -- toxicity KW - Alcoholism -- rehabilitation KW - Disease Models, Animal KW - Alcohol Deterrents -- administration & dosage KW - Alcohol Deterrents -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68843169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+biology&rft.atitle=Can+experimental+paradigms+and+animal+models+be+used+to+discover+clinically+effective+medications+for+alcoholism%3F&rft.au=Egli%2C+Mark&rft.aulast=Egli&rft.aufirst=Mark&rft.date=2005-12-01&rft.volume=10&rft.issue=4&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Addiction+biology&rft.issn=13556215&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-04-03 N1 - Date created - 2005-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Molecularly targeted therapy for pediatric brain tumors. AN - 68839572; 16195796 AB - Treatment of pediatric brain tumors remains a challenge because of the toxicity associated with conventional treatment and the relative resistance of tumors at the time of recurrence. The traditional approach of administering cytotoxic agents at the maximum tolerated dose is being supplanted by the development of molecularly targeted agents aimed at critical cellular changes that are responsible for the growth and spread of cancer cells. These agents theoretically should be more specific for tumor cells and less toxic to normal cells. While the idea of targeted therapy has generated much excitement in the oncology community, the degree of benefit to patients with central nervous system (CNS) tumors remains unclear. Numerous challenges remain in the development of these agents, including identification of meaningful targets, delivery of agents in sufficient quantity at the target site, and determination of any biologic response to these agents. This article discusses the rationale behind several of these agents and their use in pediatric patients with brain tumors. JF - Journal of neuro-oncology AU - K E, Warren AD - National Cancer Institute, Neuro-Oncology Branch, Bloch Bldg, 82, Rm 224, 9030 Old Georgetown Road, Bethesda, Maryland 20892-8200, USA. warrenk@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 335 EP - 343 VL - 75 IS - 3 SN - 0167-594X, 0167-594X KW - Antineoplastic Agents KW - 0 KW - Enzyme Inhibitors KW - Platelet-Derived Growth Factor KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Receptor, Epidermal Growth Factor -- drug effects KW - Humans KW - Platelet-Derived Growth Factor -- drug effects KW - Receptor, Epidermal Growth Factor -- physiology KW - Child KW - Platelet-Derived Growth Factor -- physiology KW - Enzyme Inhibitors -- therapeutic use KW - Brain Neoplasms -- drug therapy KW - Brain Neoplasms -- genetics KW - Enzyme Inhibitors -- pharmacology KW - Brain Neoplasms -- physiopathology KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68839572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuro-oncology&rft.atitle=Molecularly+targeted+therapy+for+pediatric+brain+tumors.&rft.au=K+E%2C+Warren&rft.aulast=K+E&rft.aufirst=Warren&rft.date=2005-12-01&rft.volume=75&rft.issue=3&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuro-oncology&rft.issn=0167594X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-28 N1 - Date created - 2005-11-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Endogenous PACAP acts as a stress response peptide to protect cerebellar neurons from ethanol or oxidative insult. AN - 68831645; 16009465 AB - The rodent cerebellum is richly supplied with PACAPergic innervation. Exogenous pituitary adenylate cyclase-activating polypeptide (PACAP) increases cerebellar granule cell survival and differentiation in culture, and enhances the number of neuroblasts in the molecular and internal granule cell layers (IGL) when injected postnatally into the cerebellum in vivo. Here, we have investigated the role of endogenous PACAP during cerebellar development by comparing the morphology of normal and PACAP-deficient mouse cerebellum, and the response of cerebellar granule cells from normal and PACAP-deficient mice subjected to neurotoxic insult in culture. There was no difference in cerebellar volume or granule cell number, in 11-day-old wild type versus PACAP-deficient mice. Cultured cerebellar neurons from PACAP-deficient and wild type mice also showed no apparent differences in survival and differentiation either under depolarizing conditions, or non-depolarizing conditions in the presence or absence of either dibutyryl cAMP or 100 nM PACAP. However, cultured cerebellar neurons from PACAP-deficient mice were significantly more sensitive than wild type neurons to ethanol- or hydrogen peroxide-induced toxicity. Differential ethanol toxicity was reversed by addition of 100 nM exogenous PACAP, suggesting that endogenous PACAP has neuroprotective activity in the context of cellular insult or stress. The neuroprotective action of PACAP was mimicked by dibutryl cAMP, indicating that it occurred via activation of adenylate cyclase. These results indicate that PACAP might act to protect the brain from paraphysiological insult, including exposure to toxins or hypoxia. JF - Peptides AU - Vaudry, David AU - Hamelink, Carol AU - Damadzic, Ruslan AU - Eskay, Robert L AU - Gonzalez, Bruno AU - Eiden, Lee E AD - Section on Molecular Neuroscience, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, 49 Convent Drive, Rm. 5A68, MSC 4090, 9000 Rockville Pike, Bethesda, MD 20892-4483, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 2518 EP - 2524 VL - 26 IS - 12 SN - 0196-9781, 0196-9781 KW - Anti-Infective Agents, Local KW - 0 KW - Pituitary Adenylate Cyclase-Activating Polypeptide KW - Ethanol KW - 3K9958V90M KW - Hydrogen Peroxide KW - BBX060AN9V KW - Index Medicus KW - Animals KW - Cells, Cultured KW - Mice KW - Mice, Knockout KW - Hydrogen Peroxide -- toxicity KW - Cerebellum -- cytology KW - Neurons -- metabolism KW - Pituitary Adenylate Cyclase-Activating Polypeptide -- pharmacology KW - Cerebellum -- growth & development KW - Neurons -- cytology KW - Oxidative Stress -- drug effects KW - Ethanol -- toxicity KW - Anti-Infective Agents, Local -- toxicity KW - Pituitary Adenylate Cyclase-Activating Polypeptide -- metabolism KW - Pituitary Adenylate Cyclase-Activating Polypeptide -- deficiency KW - Cerebellum -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68831645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Peptides&rft.atitle=Endogenous+PACAP+acts+as+a+stress+response+peptide+to+protect+cerebellar+neurons+from+ethanol+or+oxidative+insult.&rft.au=Vaudry%2C+David%3BHamelink%2C+Carol%3BDamadzic%2C+Ruslan%3BEskay%2C+Robert+L%3BGonzalez%2C+Bruno%3BEiden%2C+Lee+E&rft.aulast=Vaudry&rft.aufirst=David&rft.date=2005-12-01&rft.volume=26&rft.issue=12&rft.spage=2518&rft.isbn=&rft.btitle=&rft.title=Peptides&rft.issn=01969781&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-28 N1 - Date created - 2005-11-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Novel molecular targeted therapy for esophageal cancer. AN - 68825908; 16299785 AB - Esophageal cancers are highly lethal neoplasms which are generally refractory to conventional multidisciplinary interventions. Recent elucidation of the mechanisms of esophageal carcinogenesis, as well as preclinical studies utilizing chromatin remodeling agents and inhibitors of oncogene signaling in conjunction with conventional chemotherapeutic agents provide new opportunities for the development of potentially efficacious molecular targeted therapies for these malignancies. (c) 2005 Wiley-Liss, Inc. JF - Journal of surgical oncology AU - Schrump, David S AU - Nguyen, Dao M AD - Thoracic Oncology Section, Surgery Branch, National Cancer Institute, Bldg. 10, Rm. 4-3490, 10 Center Drive MSC 1201, Bethesda, MD 20892, USA. David_Schrump@nih.gov Y1 - 2005/12/01/ PY - 2005 DA - 2005 Dec 01 SP - 257 EP - 261 VL - 92 IS - 3 SN - 0022-4790, 0022-4790 KW - Depsipeptides KW - 0 KW - Glycoproteins KW - Histone Deacetylase Inhibitors KW - tissue-factor-pathway inhibitor 2 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Animals KW - Drug Screening Assays, Antitumor KW - Apoptosis KW - Genes, Tumor Suppressor KW - Humans KW - Clinical Trials as Topic KW - Paclitaxel -- pharmacology KW - Adenocarcinoma -- genetics KW - Mitogen-Activated Protein Kinases -- physiology KW - Adenocarcinoma -- pathology KW - Gene Expression Regulation, Neoplastic KW - Barrett Esophagus -- pathology KW - DNA Methylation KW - Glycoproteins -- metabolism KW - Barrett Esophagus -- genetics KW - Depsipeptides -- pharmacology KW - Protein Kinase C -- physiology KW - Signal Transduction KW - Cell Transformation, Neoplastic KW - Esophageal Neoplasms -- prevention & control KW - Esophageal Neoplasms -- metabolism KW - Esophageal Neoplasms -- genetics KW - Esophageal Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68825908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+surgical+oncology&rft.atitle=Novel+molecular+targeted+therapy+for+esophageal+cancer.&rft.au=Schrump%2C+David+S%3BNguyen%2C+Dao+M&rft.aulast=Schrump&rft.aufirst=David&rft.date=2005-12-01&rft.volume=92&rft.issue=3&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Journal+of+surgical+oncology&rft.issn=00224790&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-23 N1 - Date created - 2005-11-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevalence, correlates, co-morbidity, and comparative disability of DSM-IV generalized anxiety disorder in the USA: results from the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 68824459; 16202187 AB - This study addressed the prevalences, correlates, co-morbidity and disability of DSM-IV generalized anxiety disorder (GAD) and other psychiatric disorders in a large national survey of the general population, the National Institute on Alcohol Abuse and Alcoholism's (NIAAA) National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). The study presents nationally representative data, for the first time, on prevalence, correlates, co-morbidity, and comparative disability of DSM-IV GAD. Data are taken from a large (n=43093) representative sample of the adult USA population.R: Prevalences of 12-month and lifetime GAD were 2.1% and 4.1%. Being female, middle-aged, widowed/separated/divorced, and low income increased risk, while being Asian, Hispanic, or Black decreased risk. GAD was highly co-morbid with substance use, and other anxiety, mood, and personality disorders. Co-morbidity in GAD was not substantially greater than for most other Axis I and II disorders. Disability and impairment in pure GAD were equivalent to pure mood disorders, but significantly greater than in pure substance use, and other anxiety and personality disorders. Individuals co-morbid for GAD and each mood disorder were more disabled than those with pure forms of GAD or each mood disorder. When co-morbid with GAD, nicotine dependence and other anxiety and personality disorders were not associated with increased disability over that associated with pure GAD, but GAD did show increased disability over that due to each of these disorders in pure form.Conclusions. Associations between GAD and Axis I and II disorders were strong and significant, with variation among specific disorders. Results strongly support GAD as an independent disorder with significant impairment and disability. JF - Psychological medicine AU - Grant, Bridget F AU - Hasin, Deborah S AU - Stinson, Frederick S AU - Dawson, Deborah A AU - June Ruan, W AU - Goldstein, Risë B AU - Smith, Sharon M AU - Saha, Tulshi D AU - Huang, Boji AD - Laboratory of Epidemiology and Biometry, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-9304, USA. bgrant@willco.niaaa.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1747 EP - 1759 VL - 35 IS - 12 SN - 0033-2917, 0033-2917 KW - Index Medicus KW - United States KW - Severity of Illness Index KW - Humans KW - Adult KW - Middle Aged KW - Adolescent KW - Sex Distribution KW - Male KW - Female KW - Comorbidity KW - Prevalence KW - Alcoholism -- epidemiology KW - Anxiety Disorders -- psychology KW - Alcoholism -- diagnosis KW - Anxiety Disorders -- diagnosis KW - Disability Evaluation KW - Anxiety Disorders -- epidemiology KW - Diagnostic and Statistical Manual of Mental Disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68824459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+medicine&rft.atitle=Prevalence%2C+correlates%2C+co-morbidity%2C+and+comparative+disability+of+DSM-IV+generalized+anxiety+disorder+in+the+USA%3A+results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Grant%2C+Bridget+F%3BHasin%2C+Deborah+S%3BStinson%2C+Frederick+S%3BDawson%2C+Deborah+A%3BJune+Ruan%2C+W%3BGoldstein%2C+Ris%C3%AB+B%3BSmith%2C+Sharon+M%3BSaha%2C+Tulshi+D%3BHuang%2C+Boji&rft.aulast=Grant&rft.aufirst=Bridget&rft.date=2005-12-01&rft.volume=35&rft.issue=12&rft.spage=1747&rft.isbn=&rft.btitle=&rft.title=Psychological+medicine&rft.issn=00332917&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-10 N1 - Date created - 2005-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Childhood exposure to environmental tobacco smoke and chronic respiratory symptoms in non-smoking adults: the Singapore Chinese Health Study. AN - 68819506; 16131525 AB - Childhood exposure to environmental tobacco smoke has been extensively associated with childhood respiratory illness; fewer studies have addressed the effects on adults. Childhood environmental tobacco smoke exposure in relation to chronic cough, phlegm, and asthma diagnosis was studied in never smokers from a cohort of Singaporeans of Chinese ethnicity aged 45-74 years at enrollment from 1993 to 1998. From 1999 to 2004 subjects were interviewed regarding environmental tobacco smoke exposure before and after the age of 18 and the presence and duration of current symptoms of chronic cough and phlegm production and asthma diagnosis. Among 35,000 never smokers, fewer had smoking mothers (19%) than fathers (48%). Although few subjects currently lived (20%) or worked (4%) with smokers, 65% reported living with a daily smoker before the age of 18 years. Living with a smoker before the age of 18 increased the odds of chronic dry cough (149 cases, odds ratio 2.1, 95% CI 1.4 to 3.3) and, to a lesser extent, phlegm, after adjustment for age, sex, dialect group, and current and past exposure to smokers at home and at work after the age of 18. Associations strengthened with higher numbers of smokers in childhood. There was no association with asthma or chronic bronchitis. There was evidence to suggest a stronger association among subjects with a lower adult intake of fibre which has previously been found to be protective for respiratory symptoms. In this large study of non-smokers, living with a smoker in childhood was associated with chronic dry cough and phlegm in adulthood, independent of later exposures to environmental tobacco smoke. JF - Thorax AU - David, G L AU - Koh, W-P AU - Lee, H-P AU - Yu, M C AU - London, S J AD - Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, P O Box 12233, Mail Drop A3-05, Research Triangle Park, NC 27709, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1052 EP - 1058 VL - 60 IS - 12 SN - 0040-6376, 0040-6376 KW - Tobacco Smoke Pollution KW - 0 KW - Index Medicus KW - Humans KW - Infant, Newborn KW - Aged KW - Child KW - Child, Preschool KW - Cough -- etiology KW - Infant KW - Singapore -- epidemiology KW - Adult KW - Cough -- ethnology KW - Middle Aged KW - Chronic Disease KW - Adolescent KW - China -- ethnology KW - Male KW - Female KW - Tobacco Smoke Pollution -- statistics & numerical data KW - Respiratory Tract Diseases -- etiology KW - Respiratory Tract Diseases -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68819506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Thorax&rft.atitle=Childhood+exposure+to+environmental+tobacco+smoke+and+chronic+respiratory+symptoms+in+non-smoking+adults%3A+the+Singapore+Chinese+Health+Study.&rft.au=David%2C+G+L%3BKoh%2C+W-P%3BLee%2C+H-P%3BYu%2C+M+C%3BLondon%2C+S+J&rft.aulast=David&rft.aufirst=G&rft.date=2005-12-01&rft.volume=60&rft.issue=12&rft.spage=1052&rft.isbn=&rft.btitle=&rft.title=Thorax&rft.issn=00406376&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-19 N1 - Date created - 2005-11-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Respir Crit Care Med. 1997 Nov;156(5):1447-52 [9372659] J Asthma. 1997;34(1):67-76 [9033442] Am J Respir Crit Care Med. 1998 Sep;158(3):802-6 [9731008] Am J Respir Crit Care Med. 1998 Nov;158(5 Pt 1):1493-8 [9817698] Am J Respir Crit Care Med. 1999 Apr;159(4 Pt 1):1257-66 [10194174] Thorax. 1999 Apr;54(4):357-66 [10092699] JAMA. 2005 Sep 28;294(12):1505-10 [16189363] QJM. 1999 Sep;92(9):527-30 [10627873] Environ Health Perspect. 2001 Aug;109 Suppl 4:573-8 [11544166] Chest. 2001 Sep;120(3):711-7 [11555497] Nutr Cancer. 2001;39(2):187-95 [11759279] J Epidemiol Community Health. 2002 Mar;56(3):167-70 [11854334] Am J Clin Nutr. 2002 Mar;75(3):492-8 [11864854] Epidemiology. 2002 May;13(3):268-76 [11964927] Scand J Work Environ Health. 2002;28 Suppl 2:52-70 [12058803] Am J Respir Crit Care Med. 2003 Jan 1;167(1):45-9 [12502475] Am J Respir Crit Care Med. 2003 Mar 15;167(6):911-6 [12623860] Cancer Epidemiol Biomarkers Prev. 2003 Sep;12(9):890-8 [14504200] N Engl J Med. 2003 Oct 9;349(15):1414-22 [14534334] Diabetes Care. 2004 Mar;27(3):752-7 [14988297] Thorax. 2004 Apr;59(4):274-6 [15047943] Thorax. 2004 Apr;59(4):295-302 [15047948] J Allergy Clin Immunol. 2004 May;113(5):845-52 [15131565] Am J Respir Crit Care Med. 2004 Aug 1;170(3):279-87 [15117740] Am Rev Respir Dis. 1978 Dec;118(6 Pt 2):1-120 [742764] Am Rev Respir Dis. 1986 Jun;133(6):1171-80 [3717766] Singapore Med J. 1988 Apr;29(2):119-24 [3399913] Singapore Med J. 1988 Jun;29(3):233-9 [3187574] Am Rev Respir Dis. 1988 Aug;138(2):296-9 [3195829] Int J Epidemiol. 1993 Oct;22(5):809-17 [8282459] BMJ. 1994 Jul 9;309(6947):90-3 [8038673] Am J Respir Crit Care Med. 1994 Nov;150(5 Pt 1):1222-8 [7952544] Eur J Clin Nutr. 1994 Jul;48(7):522-4 [7956995] J AOAC Int. 1995 Jan-Feb;78(1):22-36 [7703724] JAMA. 1996 Apr 24;275(16):1233-40 [8601954] BMJ. 1996 May 11;312(7040):1195-9 [8634562] Lancet. 1998 Aug 8;352(9126):453 [9708758] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Incidence of haematopoietic malignancies in US radiologic technologists. AN - 68819095; 16299095 AB - There are limited data on risks of haematopoietic malignancies associated with protracted low-to-moderate dose radiation. To contribute the first incidence risk estimates for haematopoietic malignancies in relation to work history, procedures, practices, and protective measures in a large population of mostly female medical radiation workers. The investigators followed up 71,894 (77.9% female) US radiologic technologists, first certified during 1926-80, from completion of a baseline questionnaire (1983-89) to return of a second questionnaire (1994-98), diagnosis of a first cancer, death, or 31 August 1998 (731,306 person-years), whichever occurred first. Cox proportional hazards regression was used to compute risks. Relative risks (RR) for leukaemias other than chronic lymphocytic leukaemia (non-CLL, 41 cases) were increased among technologists working five or more years before 1950 (RR = 6.6, 95% CI 1.0 to 41.9, based on seven cases) or holding patients 50 or more times for x ray examination (RR = 2.6, 95% CI 1.3 to 5.4). Risks of non-CLL leukaemias were not significantly related to the number of years subjects worked in more recent periods, the year or age first worked, the total years worked, specific procedures or equipment used, or personal radiotherapy. Working as a radiologic technologist was not significantly linked with risk of multiple myeloma (28 cases), non-Hodgkin's lymphoma (118 cases), Hodgkin's lymphoma (31 cases), or chronic lymphocytic leukaemia (23 cases). Similar to results for single acute dose and fractionated high dose radiation exposures, there was increased risk for non-CLL leukaemias decades after initial protracted radiation exposure that likely cumulated to low-to-moderate doses. JF - Occupational and environmental medicine AU - Linet, M S AU - Freedman, D M AU - Mohan, A K AU - Doody, M M AU - Ron, E AU - Mabuchi, K AU - Alexander, B H AU - Sigurdson, A AU - Hauptmann, M AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD 20892, USA. linetm@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 861 EP - 867 VL - 62 IS - 12 KW - Index Medicus KW - Occupational Exposure KW - Radiation Dosage KW - Age Factors KW - Sex Factors KW - Humans KW - Risk Assessment KW - Lymphoma -- mortality KW - Lymphoma -- epidemiology KW - Leukemia -- mortality KW - Leukemia -- epidemiology KW - Multiple Myeloma -- epidemiology KW - Adult KW - Cohort Studies KW - Incidence KW - Middle Aged KW - United States -- epidemiology KW - Time Factors KW - Multiple Myeloma -- mortality KW - Female KW - Male KW - Proportional Hazards Models KW - Personnel, Hospital KW - Neoplasms, Radiation-Induced -- epidemiology KW - Technology, Radiologic -- manpower KW - Neoplasms, Radiation-Induced -- mortality KW - Hematologic Neoplasms -- epidemiology KW - Hematologic Neoplasms -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68819095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+environmental+medicine&rft.atitle=Incidence+of+haematopoietic+malignancies+in+US+radiologic+technologists.&rft.au=Linet%2C+M+S%3BFreedman%2C+D+M%3BMohan%2C+A+K%3BDoody%2C+M+M%3BRon%2C+E%3BMabuchi%2C+K%3BAlexander%2C+B+H%3BSigurdson%2C+A%3BHauptmann%2C+M&rft.aulast=Linet&rft.aufirst=M&rft.date=2005-12-01&rft.volume=62&rft.issue=12&rft.spage=861&rft.isbn=&rft.btitle=&rft.title=Occupational+and+environmental+medicine&rft.issn=1470-7926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-03 N1 - Date created - 2005-11-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Radiol Prot. 2000 Dec;20(4):353-9 [11140709] Nucleonics. 1949 Dec;5(6):63-6 [15394470] Health Phys. 2002 Apr;82(4):455-66 [11906134] Int J Cancer. 2003 Jan 10;103(2):259-67 [12455042] Semin Ultrasound CT MR. 2002 Oct;23(5):428-42 [12509113] Am J Epidemiol. 1975 Mar;101(3):199-210 [1115059] Radiology. 1978 Mar;126(3):677-9 [628739] Br J Radiol. 1981 Mar;54(639):187-94 [7470779] JAMA. 1990 Aug 1;264(5):601-4 [2366300] Br J Radiol. 1991 May;64(761):455-60 [2036572] Cancer. 1992 Jan 15;69(2):586-98 [1728391] Radiat Res. 1995 Apr;142(1):1-11 [7899552] Radiat Res. 1995 May;142(2):117-32 [7724726] Radiat Res. 1995 Nov;144(2):160-9 [7480642] Am J Epidemiol. 1997 Jan 1;145(1):72-80 [8982025] J Radiol Prot. 1999 Mar;19(1):3-26 [10321692] J Epidemiol. 1999 Apr;9(2):61-72 [10337078] Radiat Res. 1999 Sep;152(3):280-92 [10453089] Radiology. 1953 Feb;60(2):186-91 [13112398] Am J Roentgenol Radium Ther Nucl Med. 1957 Dec;78(6):988-92 [13478785] Science. 1963 Dec 13;142(3598):1492-4 [14077037] Br J Radiol. 2001 Jun;74(882):507-19 [11459730] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Epidural fentanyl speeds the onset of sensory and motor blocks during epidural ropivacaine anesthesia. AN - 68816252; 16301269 AB - In this study we examined the onset times of sensory and motor block during epidural ropivacaine anesthesia with and without the addition of fentanyl to the epidural solution. Forty-five young male patients undergoing knee arthroscopic surgery were randomly allocated into 3 groups of 15 patients each: epidural fentanyl (EF; epidural administration of 15 mL of 1% ropivacaine plus 100 mug fentanyl followed by IV injection of 2 mL of normal saline); IV fentanyl (IF; epidural administration of 15 mL of 1% ropivacaine plus 2 mL of normal saline followed by IV injection of 100 mug fentanyl); and control (C; epidural administration of 15 mL of 1% ropivacaine plus 2 mL of normal saline followed by IV injection of 2 mL of normal saline). The sensory and motor blocks were assessed by pinprick and modified Bromage scale, respectively. The hemodynamic changes, postepidural shivering, and side effects of epidural fentanyl were also recorded. There was no difference in the distribution of age, weight, and height among the 3 groups. The onset time of sensory block to the T10 dermatome was significantly more rapid in the EF group (13.0 +/- 3.0 min) than in the IF group (16.2 +/- 3.5 min, P < 0.05) or C group (17.7 +/- 3.6 min, P < 0.05). The onset times of motor block up to Bromage scale 1 and 2 were significantly more rapid in the EF group (11.9 +/- 4.6 and 24.4 +/- 5.9 min) than in the IF group (16.9 +/- 4.7 and 30.8 +/- 5.6 min, P < 0.05) or C group (18.3 +/- 4.9 and 32.7 +/- 5.7 min, P < 0.05). There was no difference in the incidence of shivering among the three groups. Pruritus was observed in three patients of the EF group and one patient of the IF group. No nausea, vomiting, respiratory depression, urinary retention, or hypotension was observed in any patient. We conclude that epidural administration of the mixture of 100 mug fentanyl and 1% ropivacaine solution accelerated the onset of sensory and motor blocks during epidural ropivacaine anesthesia without significant fentanyl-related side effects. JF - Anesthesia and analgesia AU - Cherng, Chen-Hwan AU - Yang, Chih-Ping AU - Wong, Chih-Shung AD - Department of Anesthesiology, Tri-Service General Hospital, No. 325, Sec. 2, Cheng-Gung Road, Nei-Hu, 114, Taipei, Taiwan. cherng1018@yahoo.com.tw Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1834 EP - 1837 VL - 101 IS - 6 SN - 0003-2999, 0003-2999 KW - Amides KW - 0 KW - Analgesics, Opioid KW - Anesthetics, Local KW - ropivacaine KW - 7IO5LYA57N KW - Fentanyl KW - UF599785JZ KW - Abridged Index Medicus KW - Index Medicus KW - Prospective Studies KW - Arthroscopy KW - Double-Blind Method KW - Humans KW - Adult KW - Drug Synergism KW - Sensation KW - Knee -- surgery KW - Amides -- pharmacology KW - Anesthetics, Local -- pharmacology KW - Analgesics, Opioid -- pharmacology KW - Fentanyl -- pharmacology KW - Anesthesia, Epidural -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68816252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesia+and+analgesia&rft.atitle=Epidural+fentanyl+speeds+the+onset+of+sensory+and+motor+blocks+during+epidural+ropivacaine+anesthesia.&rft.au=Cherng%2C+Chen-Hwan%3BYang%2C+Chih-Ping%3BWong%2C+Chih-Shung&rft.aulast=Cherng&rft.aufirst=Chen-Hwan&rft.date=2005-12-01&rft.volume=101&rft.issue=6&rft.spage=1834&rft.isbn=&rft.btitle=&rft.title=Anesthesia+and+analgesia&rft.issn=00032999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-20 N1 - Date created - 2005-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Brain hyperthermia as physiological and pathological phenomena. AN - 68807323; 15890410 AB - Although brain metabolism consumes high amounts of energy and is accompanied by intense heat production, brain temperature is usually considered a stable, tightly "regulated" homeostatic parameter. Current research, however, revealed relatively large and rapid brain temperature fluctuations (3-4 degrees C) in animals during various normal, physiological, and behavioral activities at stable ambient temperatures. This review discusses these data and demonstrates that physiological brain hyperthermia has an intra-brain origin, resulting from enhanced neural metabolism and increased intra-brain heat production. Therefore, brain temperature is an important physiological parameter that both reflects alterations in metabolic neural activity and affects various neural functions. This work also shows that brain hyperthermia may be induced by various drugs of abuse that cause metabolic brain activation and impair heat dissipation. While individual drugs (i.e., heroin, cocaine, methamphetamine, MDMA) have specific, dose-dependent effects on brain and body temperatures, these effects are strongly modulated by an individual's activity state and environmental conditions, and change dramatically during the development of drug self-administration. Thus, brain thermorecording may provide new information on the central effects of various addictive drugs, drug-activity-environment interactions in mediating drugs' adverse effects, and alterations in metabolic neural activity associated with the development of drug-seeking and drug-taking behavior. While ambient temperatures and impairment of heat dissipation may also affect brain temperature, these environmental conditions strongly potentiate thermal effects of psychomotor stimulant drugs, resulting in pathological brain overheating. Since hyperthermia exacerbates drug-induced toxicity and is destructive to neural cells and brain functions, use of these drugs under activated conditions that restrict heat loss may pose a significant health risk, resulting in both acute life-threatening complications and chronic destructive CNS changes. JF - Brain research. Brain research reviews AU - Kiyatkin, Eugene A AD - Cellular Neurobiology Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, DHHS, 5500 Nathan Shock, Baltimore, MD 21224, USA. ekiyatki@intra.nida.nih.gov Y1 - 2005/12/01/ PY - 2005 DA - 2005 Dec 01 SP - 27 EP - 56 VL - 50 IS - 1 KW - Adrenergic Uptake Inhibitors KW - 0 KW - Narcotics KW - Index Medicus KW - Animals KW - Adrenergic Uptake Inhibitors -- adverse effects KW - Humans KW - Narcotics -- adverse effects KW - Body Temperature -- physiology KW - Fever -- pathology KW - Brain Diseases -- chemically induced KW - Fever -- physiopathology KW - Brain Diseases -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68807323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research.+Brain+research+reviews&rft.atitle=Brain+hyperthermia+as+physiological+and+pathological+phenomena.&rft.au=Kiyatkin%2C+Eugene+A&rft.aulast=Kiyatkin&rft.aufirst=Eugene&rft.date=2005-12-01&rft.volume=50&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Brain+research.+Brain+research+reviews&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-30 N1 - Date created - 2005-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Molecular mechanisms of hexavalent chromium-induced apoptosis in human bronchoalveolar cells. AN - 68806698; 16166740 AB - Hexavalent chromium (Cr[VI]) is classified by the International Agency for Research on Cancer as a group I carcinogen. Although the U.S. Occupational Safety and Health Administration was obliged to reduce the permissible exposure limit (PEL), it was reported that U.S. workers continue to be exposed to dangerously high Cr(VI) levels. In this study, we examined the role of p53 and target genes in a bronchoalveolar carcinoma isogenic cell line system and in primary human bronchial epithelial cells. p53-Negative parental H358 cell line, the same line in which the wild-type p53 expression vector (pC53-SN3) was introduced, and cells obtained from biopsies of human bronchus were exposed to chromate. Induction of DNA strand breaks were evaluated by alkaline elution assay, and apoptosis was analyzed by gel ladder, annexin V-PI staining, and ELISA, whereas p53 and target genes were evaluated by Western blots. Although Cr(VI) induced DNA strand breaks in both H358 cell clones, apoptosis was present only in the p53-transfected cells (H358p53(+/+)). In these cells, Cr(VI)-induced apoptosis is mediated by p53 upregulation of p53-upregulated modulator of apoptosis (PUMA), BAX translocation to mitochondria, cytochrome c release, and caspase-3 activation. In primary human bronchial epithelial cells expressing functional p53, Cr(VI) induced expression of PUMA and Noxa, which promote apoptosis through BAX. This result establishes p53 as the "necessary" player in Cr(VI)-induced apoptosis. To the best of our knowledge, this is the first report indicating strict correlation of Cr(VI) apoptosis to PUMA induction on primary human bronchoalveolar cells in short-term cultures. JF - American journal of respiratory cell and molecular biology AU - Russo, Patrizia AU - Catassi, Alessia AU - Cesario, Alfredo AU - Imperatori, Andrea AU - Rotolo, Nicola AU - Fini, Massimo AU - Granone, Pierluigi AU - Dominioni, Lorenzo AD - Department of Integrated Medical Oncology (DOMI), Laboratory of Translational Research B (Lung Cancer), National Cancer Institute, Largo Rosanna Benzi 10, I-16132 Genoa, Italy. patrizia.russo@istge.it Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 589 EP - 600 VL - 33 IS - 6 SN - 1044-1549, 1044-1549 KW - Apoptosis Regulatory Proteins KW - 0 KW - BBC3 protein, human KW - Carcinogens, Environmental KW - Proto-Oncogene Proteins KW - Tumor Suppressor Protein p53 KW - bcl-2-Associated X Protein KW - Chromium KW - 0R0008Q3JB KW - chromium hexavalent ion KW - 18540-29-9 KW - Cytochromes c KW - 9007-43-6 KW - CASP3 protein, human KW - EC 3.4.22.- KW - Caspase 3 KW - Caspases KW - Index Medicus KW - Cytochromes c -- metabolism KW - Humans KW - Biopsy KW - Bronchi -- drug effects KW - Caspases -- metabolism KW - bcl-2-Associated X Protein -- metabolism KW - DNA Damage -- drug effects KW - Epithelial Cells -- metabolism KW - Epithelial Cells -- drug effects KW - Tumor Cells, Cultured KW - Bronchi -- cytology KW - Mitochondria -- drug effects KW - Enzyme Activation -- drug effects KW - Mitochondria -- metabolism KW - Enzyme-Linked Immunosorbent Assay KW - Up-Regulation KW - Bronchi -- metabolism KW - Protein Transport KW - Adenocarcinoma, Bronchiolo-Alveolar -- drug therapy KW - Lung Neoplasms -- drug therapy KW - Apoptosis Regulatory Proteins -- metabolism KW - Apoptosis -- drug effects KW - Proto-Oncogene Proteins -- metabolism KW - Adenocarcinoma, Bronchiolo-Alveolar -- metabolism KW - Carcinogens, Environmental -- toxicity KW - Chromium -- toxicity KW - Tumor Suppressor Protein p53 -- metabolism KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68806698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=Molecular+mechanisms+of+hexavalent+chromium-induced+apoptosis+in+human+bronchoalveolar+cells.&rft.au=Russo%2C+Patrizia%3BCatassi%2C+Alessia%3BCesario%2C+Alfredo%3BImperatori%2C+Andrea%3BRotolo%2C+Nicola%3BFini%2C+Massimo%3BGranone%2C+Pierluigi%3BDominioni%2C+Lorenzo&rft.aulast=Russo&rft.aufirst=Patrizia&rft.date=2005-12-01&rft.volume=33&rft.issue=6&rft.spage=589&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+cell+and+molecular+biology&rft.issn=10441549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-11-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Biophys Res Commun. 2000 Apr 2;270(1):303-10 [10733944] Cancer. 2005 Apr 1;103(7):1503-18 [15700263] Am J Ind Med. 2000 Aug;38(2):115-26 [10893504] Carcinogenesis. 2001 May;22(5):757-62 [11323395] Am J Respir Cell Mol Biol. 2001 Jun;24(6):703-10 [11415935] Mol Cell. 2001 Mar;7(3):673-82 [11463391] Mol Cell. 2001 Mar;7(3):683-94 [11463392] Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11318-23 [11572983] Hum Exp Toxicol. 2001 Sep;20(9):439-51 [11776406] Int J Cancer. 2002 Feb 20;97(6):732-9 [11857347] Mol Carcinog. 2002 Mar;33(3):172-80 [11870883] Carcinogenesis. 2002 Apr;23(4):587-93 [11960910] Am J Ind Med. 2002 Nov;42(5):378-83 [12382250] J Pharmacol Exp Ther. 2003 Jan;304(1):37-47 [12490573] Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1931-6 [12574499] Occup Environ Med. 2003 Jun;60(6):451-7 [12771398] J Thorac Cardiovasc Surg. 2003 Jun;125(6):1321-7 [12830051] Mutat Res. 2003 Dec 10;533(1-2):3-36 [14643411] Cancer Res. 2004 Jan 1;64(1):135-45 [14729617] Am J Ind Med. 2004 Mar;45(3):308-9; author reply 310 [14991859] Oncogene. 2004 Apr 12;23(16):2934-49 [15077155] Mol Cell Biol. 2004 Aug;24(15):6728-41 [15254240] Neoplasma. 2004;51(3):175-80 [15254669] Br J Cancer. 2004 Aug;91 Suppl 2:S31-7 [15340376] Mutat Res. 2004 Oct 4;554(1-2):241-51 [15450422] J Biol Chem. 1977 Sep 25;252(18):6438-42 [893418] Eur J Biochem. 1981 Mar 16;115(1):207-16 [7227366] Cancer Res. 1983 Dec;43(12 Pt 1):5662-7 [6640521] Cancer Res. 1985 Jul;45(7):3179-87 [4005851] Sci Total Environ. 1988 Jun 1;71(3):331-9 [3043655] Am J Ind Med. 1990;17(2):189-215 [2405656] Mutat Res. 1990 Mar;238(2):99-172 [2407950] IARC Monogr Eval Carcinog Risks Hum. 1990;49:1-648 [2232124] Mutat Res. 1993 Apr;299(2):95-102 [7680428] Chest. 1994 Mar;105(3 Suppl):67S-74S [8131616] J Biol Chem. 1995 Jan 27;270(4):1894-8 [7829527] Am J Pathol. 1996 Sep;149(3):845-52 [8780388] Annu Rev Biochem. 1996;65:43-81 [8811174] Crit Rev Toxicol. 1997 Sep;27(5):431-42 [9347224] Nucleic Acids Res. 1998 Apr 15;26(8):2024-30 [9518499] Mol Carcinog. 1998 Dec;23(4):201-6 [9869448] Biochemistry. 2004 Nov 9;43(44):14282-9 [15518579] Cancer Res. 2004 Dec 15;64(24):9217-24 [15604295] J Pathol. 2005 Jan;205(2):221-35 [15643669] Nat Rev Cancer. 2005 Mar;5(3):231-7 [15738985] Toxicol Sci. 2000 May;55(1):60-8 [10788560] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells. AN - 68805980; 16109773 AB - Retroviruses can induce hematopoietic disease via insertional mutagenesis of cancer genes and provide valuable molecular tags for cancer gene discovery. Here we show that insertional mutagenesis can also identify genes that promote the immortalization of hematopoietic cells, which normally have only limited self-renewal. Transduction of mouse bone marrow cells with replication-incompetent murine stem cell virus (MSCV) expressing only neo, followed by serial passage in liquid culture containing stem cell factor (SCF) and interleukin-3 (IL-3), produced immortalized immature myeloid cell lines with neutrophil and macrophage differentiation potential in about 50% of the infected cultures. More than half of the lines have MSCV insertions at Evi1 or Prdm16. These loci encode transcription factor homologs and are validated human myeloid leukemia genes. Integrations are located in intron 1 or 2, where they promote expression of truncated proteins lacking the PRDI-BF1-RIZ1 homologous (PR) domain, similar to what is observed in human leukemias with EVI1 or PRDM16 mutations. Evi1 overexpression alone appears sufficient to immortalize immature myeloid cells and does not seem to require any other cooperating mutations. Genes identified by insertional mutagenesis by their nature could also be involved in immortalization of leukemic stem cells, and thus represent attractive drug targets for treating cancer. JF - Blood AU - Du, Yang AU - Jenkins, Nancy A AU - Copeland, Neal G AD - Mouse Cancer Genetics Program, National Cancer Institute, Center for Cancer Research, Frederick, MD 21702, USA. Y1 - 2005/12/01/ PY - 2005 DA - 2005 Dec 01 SP - 3932 EP - 3939 VL - 106 IS - 12 SN - 0006-4971, 0006-4971 KW - DNA-Binding Proteins KW - 0 KW - MECOM protein, human KW - PRDM16 protein, human KW - Transcription Factors KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Blotting, Northern KW - Humans KW - Transduction, Genetic KW - DNA-Binding Proteins -- genetics KW - Cell Differentiation KW - Mice KW - Transcription Factors -- genetics KW - Leukemia -- genetics KW - Polymerase Chain Reaction KW - Blotting, Southern KW - Zinc Fingers -- genetics KW - Proto-Oncogenes -- genetics KW - Cell Culture Techniques -- methods KW - Flow Cytometry KW - Retroviridae -- genetics KW - Bone Marrow Cells -- virology KW - Hematopoietic Stem Cells -- physiology KW - Hematopoietic Stem Cells -- virology KW - Cell Line, Transformed KW - Mutagenesis, Insertional -- genetics KW - Bone Marrow Cells -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68805980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Insertional+mutagenesis+identifies+genes+that+promote+the+immortalization+of+primary+bone+marrow+progenitor+cells.&rft.au=Du%2C+Yang%3BJenkins%2C+Nancy+A%3BCopeland%2C+Neal+G&rft.aulast=Du&rft.aufirst=Yang&rft.date=2005-12-01&rft.volume=106&rft.issue=12&rft.spage=3932&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-18 N1 - Date created - 2005-11-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Blood. 2000 Feb 1;95(3):1007-13 [10648416] Cell. 2000 Jan 7;100(1):57-70 [10647931] Mol Cell Biol. 2000 Oct;20(20):7419-26 [11003639] Blood. 2000 Nov 1;96(9):3209-14 [11050005] Nat Med. 2000 Nov;6(11):1278-81 [11062542] J Exp Med. 2001 Feb 19;193(4):531-43 [11181704] Genesis. 2001 Jun;30(2):82-8 [11416868] Nature. 2001 Nov 1;414(6859):105-11 [11689955] Haematologica. 2001 Nov;86(11):1124-57 [11694400] Acta Haematol. 2002;107(2):76-94 [11919388] Science. 2002 Apr 19;296(5567):497 [11964471] Mol Cell. 2002 Nov;10(5):1107-17 [12453418] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8 [12629218] Nature. 2003 May 15;423(6937):255-60 [12714970] Nature. 2003 May 15;423(6937):302-5 [12714971] Nat Immunol. 2003 Jun;4(6):525-32 [12717432] Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):10002-7 [12890867] Blood Cells Mol Dis. 2003 Sep-Oct;31(2):206-12 [12972028] Blood. 2003 Nov 1;102(9):3323-32 [12816872] Haematologica. 2003 Nov;88(11):1221-8 [14607750] J Biol Chem. 2003 Dec 12;278(50):49806-11 [14555651] Genes Dev. 2003 Dec 15;17(24):3029-35 [14701873] Cancer Sci. 2004 Jun;95(6):503-7 [15182431] N Engl J Med. 2004 Aug 12;351(7):657-67 [15306667] J Clin Invest. 2004 Sep;114(5):713-9 [15343390] Blood. 1985 Dec;66(6):1362-70 [4063525] Blood. 1986 Sep;68(3):652-7 [3461853] Proc Natl Acad Sci U S A. 1990 Dec;87(23):9202-6 [2251265] Mol Cell Biol. 1992 Jan;12(1):183-9 [1370341] Proc Natl Acad Sci U S A. 1992 May 1;89(9):3937-41 [1570317] J Exp Med. 1992 Oct 1;176(4):1149-63 [1402659] Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6454-8 [8341654] Leukemia. 1993 Oct;7(10):1654-7 [8412328] Blood. 1994 Oct 15;84(8):2681-8 [7919381] Leukemia. 1996 May;10(5):788-94 [8656673] J Exp Med. 1996 May 1;183(5):2283-91 [8642337] Genomics. 1996 Oct 1;37(1):24-8 [8921366] Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14059-64 [8943060] Genes Dev. 1997 Jan 15;11(2):226-40 [9009205] Nat Med. 1997 Jul;3(7):730-7 [9212098] J Biol Chem. 1998 Jun 26;273(26):15933-9 [9632640] Blood. 1998 Jul 1;92(1):83-92 [9639503] Immunity. 1998 Jul;9(1):47-57 [9697835] Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10129-33 [9707612] Haematologica. 1999 Aug;84(8):690-4 [10457403] Cancer Cell. 2004 Dec;6(6):587-96 [15607963] Blood. 2005 Oct 1;106(7):2530-3 [15933056] Nature. 1994 Feb 17;367(6464):645-8 [7509044] Blood. 1994 Aug 15;84(4):1243-8 [8049440] Genes Dev. 1999 Oct 15;13(20):2678-90 [10541554] Leukemia. 1999 Nov;13(11):1639-45 [10557037] Histol Histopathol. 2000 Jan;15(1):109-17 [10668202] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Combined blockade of AMPA and NMDA glutamate receptors reduces levodopa-induced motor complications in animal models of PD. AN - 68805518; 16203001 AB - AMPA and NMDA receptors, abundantly expressed on striatal medium spiny neurons, have been implicated in the regulation of corticostriatal synaptic efficacy. To evaluate the contribution of both glutamate receptor types to the pathogenesis of motor response alterations associated with dopaminergic treatment, we studied the ability of the selective AMPA receptor antagonist GYKI-47261 and the selective NMDA receptor antagonists, MK-801 and amantadine, to mitigate these syndromes in rodent and primate models of Parkinson's disease. The effects of GYKI-47261 and amantadine (or MK-801), alone and in combination, were compared for their ability to modify dyskinesias induced by levodopa. In rats, simultaneous administration of subthreshold doses of AMPA and NMDA receptor antagonists completely normalized the wearing-off response to acute levodopa challenge produced by chronic levodopa treatment (P < 0.05). In primates, the glutamate antagonists GYKI-47261 and amantadine, co-administered at low doses (failing to alter dyskinesia scores), reduced levodopa-induced dyskinesias by 51% (P < 0.05). The simultaneous AMPA and NMDA receptor blockade acts to provide a substantially greater reduction in the response alterations induced by levodopa than inhibition of either of these receptors alone. The results suggest that mechanisms mediated by both ionotropic glutamate receptors make an independent contribution to the pathogenesis of these motor response changes and further that a combination of both drug types may provide relief from these disabling complications at lower and thus safer and more tolerable doses than required when either drug is used alone. JF - Experimental neurology AU - Bibbiani, F AU - Oh, J D AU - Kielaite, A AU - Collins, M A AU - Smith, C AU - Chase, T N AD - ETB, NINDS, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 422 EP - 429 VL - 196 IS - 2 SN - 0014-4886, 0014-4886 KW - Antiparkinson Agents KW - 0 KW - Benzazepines KW - Dopamine Agents KW - Dopamine Agonists KW - Excitatory Amino Acid Antagonists KW - GYKI 47261 KW - Receptors, AMPA KW - Receptors, Glutamate KW - Receptors, N-Methyl-D-Aspartate KW - Benzodiazepines KW - 12794-10-4 KW - Quinpirole KW - 20OP60125T KW - Levodopa KW - 46627O600J KW - Dizocilpine Maleate KW - 6LR8C1B66Q KW - SK&F 82958 KW - 80751-65-1 KW - Amantadine KW - BF4C9Z1J53 KW - Index Medicus KW - Rotarod Performance Test -- methods KW - Animals KW - Benzazepines -- pharmacology KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Receptors, Glutamate -- physiology KW - Disease Models, Animal KW - Haplorhini KW - Behavior, Animal KW - Dizocilpine Maleate -- pharmacology KW - Excitatory Amino Acid Antagonists -- pharmacology KW - Rats KW - Rats, Sprague-Dawley KW - Quinpirole -- pharmacology KW - Dopamine Agonists -- pharmacology KW - Motor Activity -- drug effects KW - Antiparkinson Agents -- pharmacology KW - Amantadine -- pharmacology KW - Benzodiazepines -- pharmacology KW - Time Factors KW - Male KW - Parkinson Disease, Secondary -- chemically induced KW - Receptors, N-Methyl-D-Aspartate -- physiology KW - Receptors, AMPA -- antagonists & inhibitors KW - Receptors, N-Methyl-D-Aspartate -- antagonists & inhibitors KW - Receptors, AMPA -- physiology KW - Dopamine Agents -- adverse effects KW - Levodopa -- adverse effects KW - Parkinson Disease, Secondary -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68805518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+neurology&rft.atitle=Combined+blockade+of+AMPA+and+NMDA+glutamate+receptors+reduces+levodopa-induced+motor+complications+in+animal+models+of+PD.&rft.au=Bibbiani%2C+F%3BOh%2C+J+D%3BKielaite%2C+A%3BCollins%2C+M+A%3BSmith%2C+C%3BChase%2C+T+N&rft.aulast=Bibbiani&rft.aufirst=F&rft.date=2005-12-01&rft.volume=196&rft.issue=2&rft.spage=422&rft.isbn=&rft.btitle=&rft.title=Experimental+neurology&rft.issn=00144886&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-25 N1 - Date created - 2005-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Functional characterization of novel allelic variants of CYP2C9 recently discovered in southeast Asians. AN - 68801576; 16099926 AB - CYP2C9 was recently resequenced in 150 Asian subjects from Singapore. Several new coding variants were reported, and these variants are now named CYP2C9*14 (R125H), CYP2C9*15 (S162X), CYP2C9*16 (T299A), CYP2C9*17 (P382S), CYP2C9*18 (D397A), and CYP2C9*19 (Q454H). The CYP2C9*18 variant also contained an I359L change previously associated with the CYP2C9*3 allele. In this study, we assessed the functional consequences of the new coding changes. cDNAs containing each of the new coding changes were constructed by site-directed mutagenesis and expressed in a bacterial cDNA expression system, the allelic proteins were partially purified, and their ability to hydroxylate a prototype CYP2C9 substrate was assayed. Expression of cDNAs in Escherichia coli containing either the D397A change or the S162X (premature stop codon) could not be detected either spectrally or at the apoprotein level. CYP2C9.14 and CYP2C9.16 exhibited 80 to 90% lower catalytic activity toward tolbutamide at two substrate concentrations compared with wild-type CYP2C9.1. Kinetic analysis confirmed that CYP2C9.14 and CYP2C9.16 have a higher Km and a >90% lower intrinsic clearance of tolbutamide compared with wild-type CYP2C9.1. Both CYP2C9.17 and CYP2C9.19 proteins exhibited modest 30 to 40% decreases in catalytic activity toward tolbutamide. Thus, CYP2C9*15 and CYP2C9*18 may represent null alleles, whereas CYP2C9*14 and CYP2C9*16 allelic variants produce proteins that are clearly catalytically defective in vitro, indicating the existence of new defective putative alleles of CYP2C9 in Asians. JF - The Journal of pharmacology and experimental therapeutics AU - DeLozier, Tracy C AU - Lee, Soo-Chin AU - Coulter, Sherry J AU - Goh, Boon Cher AU - Goldstein, Joyce A AD - Human Metabolism Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1085 EP - 1090 VL - 315 IS - 3 SN - 0022-3565, 0022-3565 KW - DNA, Complementary KW - 0 KW - Recombinant Proteins KW - Tolbutamide KW - 982XCM1FOI KW - CYP2C9 protein, human KW - EC 1.14.13.- KW - Cytochrome P-450 CYP2C9 KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - Index Medicus KW - India -- ethnology KW - Humans KW - Tolbutamide -- pharmacology KW - Tolbutamide -- pharmacokinetics KW - Escherichia coli -- genetics KW - Hydroxylation KW - Mutagenesis, Site-Directed KW - Recombinant Proteins -- isolation & purification KW - Tolbutamide -- metabolism KW - Recombinant Proteins -- metabolism KW - Kinetics KW - Singapore KW - China -- ethnology KW - Catalysis KW - Genetic Variation KW - Polymorphism, Single Nucleotide KW - Aryl Hydrocarbon Hydroxylases -- metabolism KW - Alleles KW - Aryl Hydrocarbon Hydroxylases -- genetics KW - Aryl Hydrocarbon Hydroxylases -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68801576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Functional+characterization+of+novel+allelic+variants+of+CYP2C9+recently+discovered+in+southeast+Asians.&rft.au=DeLozier%2C+Tracy+C%3BLee%2C+Soo-Chin%3BCoulter%2C+Sherry+J%3BGoh%2C+Boon+Cher%3BGoldstein%2C+Joyce+A&rft.aulast=DeLozier&rft.aufirst=Tracy&rft.date=2005-12-01&rft.volume=315&rft.issue=3&rft.spage=1085&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-23 N1 - Date created - 2005-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tau is hyperphosphorylated in the insulin-like growth factor-I null brain. AN - 68799875; 16123158 AB - IGF action has been implicated in the promotion of oxidative stress and aging in invertebrate and murine models. However, some in vitro models suggest that IGF-I specifically prevents neuronal oxidative damage. To investigate whether IGF-I promotes or retards brain aging, we evaluated signs of oxidative stress and neuropathological aging in brains from 400-d-old Igf1-/- and wild-type (WT) mice. Lipofuscin pigment accumulation reflects oxidative stress and aging, but we found no difference in lipofuscin deposition in Igf1-/- and WT brains. Likewise, there was no apparent difference in accumulation of nitrotyrosine residues in Igf1-/- and WT brains, except for layer IV/V of the cerebral cortex, where these proteins were about 20% higher in the Igf1-/- brain (P = 0.03). We found no difference in the levels of oxidative stress-related enzymes, neuronal nitric oxide synthase, inducible nitric oxide synthase, and superoxide dismutase in Igf1-/- and WT brains. Tau is a microtubule-associated protein that causes the formation of neurofibrillary tangles and senile plaques as it becomes hyperphosphorylated in the aging brain. Tau phosphorylation was dramatically increased on two specific residues, Ser-396 and Ser-202, both glycogen synthase kinases target sites implicated in neurodegeneration. These observations indicate that IGF-I has a major role in regulating tau phosphorylation in the aging brain, whereas its role in promoting or preventing oxidative stress remains uncertain. JF - Endocrinology AU - Cheng, Clara M AU - Tseng, Victor AU - Wang, Jie AU - Wang, Daniel AU - Matyakhina, Ludmila AU - Bondy, Carolyn A AD - Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. chengc@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 5086 EP - 5091 VL - 146 IS - 12 SN - 0013-7227, 0013-7227 KW - Lipofuscin KW - 0 KW - tau Proteins KW - 3-nitrotyrosine KW - 3604-79-3 KW - Tyrosine KW - 42HK56048U KW - Insulin-Like Growth Factor I KW - 67763-96-6 KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Aging -- metabolism KW - Phosphorylation KW - Oxidative Stress KW - Drug Residues -- metabolism KW - Mice KW - Tyrosine -- metabolism KW - Tyrosine -- analogs & derivatives KW - Male KW - Lipofuscin -- metabolism KW - Nitric Oxide Synthase -- biosynthesis KW - Mice, Knockout KW - Brain -- enzymology KW - tau Proteins -- metabolism KW - Insulin-Like Growth Factor I -- deficiency KW - Brain -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68799875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+International+Meeting+on+Tumor+Progression+and+Therapeutic+Resistance+%28TPTR+2005%29&rft.atitle=Biomarkers+and+Imaging+Endpoints+to+Accelerate+Oncologic+Drug+Development&rft.au=Kelloff%2C+Gary&rft.aulast=Kelloff&rft.aufirst=Gary&rft.date=2005-09-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+International+Meeting+on+Tumor+Progression+and+Therapeutic+Resistance+%28TPTR+2005%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-05 N1 - Date created - 2005-11-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Assessment of the integrity of study blindness in a pediatric clinical trial of risperidone. AN - 68797858; 16282839 AB - Controlled clinical trials in pediatric psychopharmacology rely on blinded parents and clinical evaluators for outcome data, but little is known about the success of the masking procedures. The blindness of clinical evaluators and parents was examined in a clinical trial of risperidone in autism. Clinical evaluators and parents were asked to guess individual treatment assignments at the end of an 8-week placebo-controlled trial of risperidone in children (aged 5-17 years) with autism. Clinical evaluators did not have access to adverse event data. The rates of correctly guessing individual treatment assignment (risperidone or placebo) were significantly greater than chance for both clinical evaluators and parents (P < 0.001). Clinical evaluators associated improvement with attribution to risperidone, and lack of improvement with attribution to placebo, in both the risperidone and placebo treatment arms. Parents associated improvement with attribution to risperidone only in the placebo treatment arm. Parents reported that adverse events influenced their guesses, but presence of adverse events was not associated with correctness of guess. Improvement was associated with attribution to active treatment regardless of actual treatment assignment, and adverse events did not appear to be a threat to study blindness. JF - Journal of clinical psychopharmacology AU - Vitiello, Benedetto AU - Davies, Mark AU - Arnold, L Eugene AU - McDougle, Christopher J AU - Aman, Michael AU - McCracken, James T AU - Scahill, Lawrence AU - Tierney, Elaine AU - Posey, David J AU - Swiezy, Naomi B AU - Koenig, Kathleen AD - Division of Services and Intervention Research, National Institute of Mental Health, Bethesda, MD 20892-9633, USA. bvitiell@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 565 EP - 569 VL - 25 IS - 6 SN - 0271-0749, 0271-0749 KW - Antipsychotic Agents KW - 0 KW - Risperidone KW - L6UH7ZF8HC KW - Index Medicus KW - Reproducibility of Results KW - Humans KW - Treatment Outcome KW - Child KW - Adolescent KW - Child, Preschool KW - Research Personnel -- psychology KW - Double-Blind Method KW - Antipsychotic Agents -- therapeutic use KW - Autistic Disorder -- drug therapy KW - Risperidone -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Risperidone -- therapeutic use KW - Parents -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68797858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+psychopharmacology&rft.atitle=Assessment+of+the+integrity+of+study+blindness+in+a+pediatric+clinical+trial+of+risperidone.&rft.au=Vitiello%2C+Benedetto%3BDavies%2C+Mark%3BArnold%2C+L+Eugene%3BMcDougle%2C+Christopher+J%3BAman%2C+Michael%3BMcCracken%2C+James+T%3BScahill%2C+Lawrence%3BTierney%2C+Elaine%3BPosey%2C+David+J%3BSwiezy%2C+Naomi+B%3BKoenig%2C+Kathleen&rft.aulast=Vitiello&rft.aufirst=Benedetto&rft.date=2005-12-01&rft.volume=25&rft.issue=6&rft.spage=565&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+psychopharmacology&rft.issn=02710749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-28 N1 - Date created - 2005-11-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Specific recognition and cleavage of the plus-strand primer by reverse transcriptase. AN - 68794383; 16282486 AB - Reverse transcriptases (RTs) of retroviruses and long terminal repeat (LTR)-retrotransposons possess DNA polymerase and RNase H activities. During reverse transcription these activities are necessary for the programmed sequence of events that include template switching and primer processing. Integrase then inserts the completed cDNA into the genome of the host cell. The RT of the LTR-retrotransposon Tf1 was subjected to random mutagenesis, and the resulting transposons were screened with genetic assays to test which mutations reduced reverse transcription and which inhibited integration. We identified a cluster of mutations in the RNase H domain of RT that were surprising because they blocked integration without reducing cDNA levels. The results of immunoblots demonstrated that these mutations did not reduce levels of RT or integrase. DNA blots showed that the mutations did not lower the amounts of full-length cDNA. The sequences of the 3' ends of the cDNA revealed that mutations within the cluster in RNase H specifically reduced the removal of the polypurine tract (PPT) primer from the ends of the cDNA. These results indicate that primer removal is not a necessary component of reverse transcription. The residues mutated in Tf1 RNase H are conserved in human immunodeficiency virus type 1 and make direct contact with DNA opposite the PPT. Thus, our results identify a conserved element in RT that contacts the PPT and is specifically required for PPT removal. JF - Journal of virology AU - Atwood-Moore, Angela AU - Ejebe, Kenechi AU - Levin, Henry L AD - Section on Eukaryotic Transposable Elements, Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 14863 EP - 14875 VL - 79 IS - 23 SN - 0022-538X, 0022-538X KW - DNA, Viral KW - 0 KW - RNA primers KW - RNA KW - 63231-63-0 KW - HIV Reverse Transcriptase KW - EC 2.7.7.49 KW - RNA-Directed DNA Polymerase KW - Ribonuclease H KW - EC 3.1.26.4 KW - Index Medicus KW - Saccharomyces cerevisiae -- genetics KW - HIV Long Terminal Repeat KW - DNA, Viral -- biosynthesis KW - Saccharomyces cerevisiae -- metabolism KW - HIV Reverse Transcriptase -- metabolism KW - Templates, Genetic KW - Substrate Specificity KW - RNA -- metabolism KW - RNA-Directed DNA Polymerase -- chemistry KW - RNA -- chemistry KW - RNA-Directed DNA Polymerase -- metabolism KW - Ribonuclease H -- metabolism KW - RNA-Directed DNA Polymerase -- genetics KW - RNA -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68794383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Specific+recognition+and+cleavage+of+the+plus-strand+primer+by+reverse+transcriptase.&rft.au=Atwood-Moore%2C+Angela%3BEjebe%2C+Kenechi%3BLevin%2C+Henry+L&rft.aulast=Atwood-Moore&rft.aufirst=Angela&rft.date=2005-12-01&rft.volume=79&rft.issue=23&rft.spage=14863&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-23 N1 - Date created - 2005-11-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 2000 May;74(10):4755-64 [10775614] J Virol. 1999 Jun;73(6):5186-90 [10233986] Biochemistry. 2002 Apr 16;41(15):4856-65 [11939780] J Biol Chem. 2002 May 10;277(19):16689-96 [11875059] Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9515-20 [12093908] J Virol. 2002 Aug;76(16):8360-73 [12134040] J Mol Biol. 2003 Dec 5;334(4):653-65 [14636594] Int J Biochem Cell Biol. 2004 Sep;36(9):1752-66 [15183342] Cell. 1990 Aug 24;62(4):829-37 [2167180] Cell. 1990 Oct 5;63(1):87-95 [2170022] EMBO J. 1990 Oct;9(10):3353-62 [1698615] Mol Cell Biol. 1990 Dec;10(12):6791-8 [2174117] Methods Enzymol. 1991;194:795-823 [2005825] J Virol. 1991 Sep;65(9):4636-44 [1870194] J Virol. 1992 Apr;66(4):2359-68 [1548767] Science. 1992 Nov 13;258(5085):1112-8 [1279806] EMBO J. 1993 Dec;12(12):4885-95 [8223497] Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):549-53 [7507249] Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9847-51 [7937903] Virology. 1994 Dec;205(2):470-8 [7975248] Mol Cell Biol. 1995 Jun;15(6):3310-7 [7760826] Mol Cell Biol. 1996 Jan;16(1):338-46 [8524313] Mol Cell Biol. 1996 Oct;16(10):5645-54 [8816477] Genes Dev. 1997 Jan 15;11(2):270-85 [9009208] J Mol Biol. 1997 Jun 6;269(2):225-39 [9191067] J Virol. 1998 Feb;72(2):1324-33 [9445033] Mol Cell Biol. 1998 Feb;18(2):1094-104 [9448007] J Virol. 1998 Aug;72(8):6490-503 [9658092] J Virol. 1998 Nov;72(11):9318-22 [9765482] Mol Cell Biol. 1998 Nov;18(11):6839-52 [9774697] EMBO J. 2001 Mar 15;20(6):1449-61 [11250910] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of CYP2E1 in the epoxidation of acrylamide to glycidamide and formation of DNA and hemoglobin adducts. AN - 68794284; 16141435 AB - Acrylamide (AA) is an animal carcinogen, neurotoxin, and reproductive toxin. AA is formed in baked and fried carbohydrate-rich foods. Metabolism of AA occurs via epoxidation to glycidamide (GA) or direct conjugation with glutathione. Using CYP2E1-null mice, recent studies in this laboratory demonstrated that induction of somatic and germ cell mutagenicity in AA-treated mice is dependent on CYP2E1. We hypothesized that AA metabolism to GA is a prerequisite for the induction of AA-induced mutagenicity. Current studies were undertaken to assess the role of CYP2E1 in the epoxidation of AA to GA and the formation of DNA and hemoglobin (HGB) adducts. AA was administered to CYP2E1-null or wild-type mice at 50 mg/kg ip. Mice were euthanized 6 h later and blood and tissues were collected. Using LC-ES/MS/MS, AA, GA, and DNA- and HGB-adducts were measured. While the plasma levels of AA and GA were 115 +/- 14.0 and 1.7 +/- 0.31 microM in CYP2E1-null mice, they were 0.84 +/- 0.80 and 33.0 +/- 6.3 microM in the plasma of AA-treated wild-type mice. Administration of AA to wild-type mice caused a large increase in N7-GA-Gua and N3-GA-Ade adducts in the liver, lung, and testes. While traces of N7-GA-Gua adducts were measured in the tissues of AA-treated CYP2E1-null mice, these levels were 52- to 66-fold lower than in wild-type mice. Significant elevation of both AA- and GA-HGB adducts was detected in AA-treated wild-type mice. In AA-treated CYP2E1-null mice, levels of AA-HGB adducts were roughly twice as high as those in wild-type mice. In conclusion, current work demonstrated that CYP2E1 is the primary enzyme responsible for the epoxidation of AA to GA, which leads to the formation of GA-DNA and HGB adducts. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Ghanayem, Burhan I AU - McDaniel, L Patrice AU - Churchwell, Mona I AU - Twaddle, Nathan C AU - Snyder, Rodney AU - Fennell, Timothy R AU - Doerge, Daniel R AD - Laboratory of Pharmacology and Chemistry, National Toxicology Program, NIEHS/NIH, Research Triangle Park, NC 27709, USA. ghanayem@niehs.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 311 EP - 318 VL - 88 IS - 2 SN - 1096-6080, 1096-6080 KW - DNA Adducts KW - 0 KW - Epoxy Compounds KW - Hemoglobins KW - Acrylamide KW - 20R035KLCI KW - glycidamide KW - 6G5ELX5XYN KW - DNA KW - 9007-49-2 KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - Index Medicus KW - Animals KW - Liver -- enzymology KW - Lung -- chemistry KW - Mice KW - Liver -- chemistry KW - DNA -- drug effects KW - Mice, Knockout KW - Testis -- drug effects KW - Liver -- drug effects KW - Lung -- drug effects KW - Mice, Inbred C57BL KW - Testis -- enzymology KW - Lung -- enzymology KW - Testis -- chemistry KW - Male KW - Hemoglobins -- metabolism KW - DNA Adducts -- chemistry KW - Cytochrome P-450 CYP2E1 -- deficiency KW - Epoxy Compounds -- metabolism KW - Epoxy Compounds -- chemistry KW - Acrylamide -- metabolism KW - Cytochrome P-450 CYP2E1 -- metabolism KW - Hemoglobins -- chemistry KW - Cytochrome P-450 CYP2E1 -- genetics KW - Acrylamide -- toxicity KW - DNA Adducts -- metabolism KW - Acrylamide -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68794284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Role+of+CYP2E1+in+the+epoxidation+of+acrylamide+to+glycidamide+and+formation+of+DNA+and+hemoglobin+adducts.&rft.au=Ghanayem%2C+Burhan+I%3BMcDaniel%2C+L+Patrice%3BChurchwell%2C+Mona+I%3BTwaddle%2C+Nathan+C%3BSnyder%2C+Rodney%3BFennell%2C+Timothy+R%3BDoerge%2C+Daniel+R&rft.aulast=Ghanayem&rft.aufirst=Burhan&rft.date=2005-12-01&rft.volume=88&rft.issue=2&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chemical effects in biological systems--data dictionary (CEBS-DD): a compendium of terms for the capture and integration of biological study design description, conventional phenotypes, and 'omics data. AN - 68792840; 16150882 AB - A critical component in the design of the Chemical Effects in Biological Systems (CEBS) Knowledgebase is a strategy to capture toxicogenomics study protocols and the toxicity endpoint data (clinical pathology and histopathology). A Study is generally an experiment carried out during a period of time for the purpose of obtaining data, and the Study Design Description captures the methods, timing, and organization of the Study. The CEBS Data Dictionary (CEBS-DD) has been designed to define and organize terms in an attempt to standardize nomenclature needed to describe a toxicogenomics Study in a structured yet intuitive format and provide a flexible means to describe a Study as conceptualized by the investigator. The CEBS-DD will organize and annotate information from a variety of sources, thereby facilitating the capture and display of toxicogenomics data in biological context in CEBS, i.e., associating molecular events detected in highly-parallel data with the toxicology/pathology phenotype as observed in the individual Study Subjects and linked to the experimental treatments. The CEBS-DD has been developed with a focus on acute toxicity studies, but with a design that will permit it to be extended to other areas of toxicology and biology with the addition of domain-specific terms. To illustrate the utility of the CEBS-DD, we present an example of integrating data from two proteomics and transcriptomics studies of the response to acute acetaminophen toxicity (A. N. Heinloth et al., 2004, Toxicol. Sci. 80, 193-202). JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Fostel, Jennifer AU - Choi, Danielle AU - Zwickl, Craig AU - Morrison, Norman AU - Rashid, Asif AU - Hasan, Atif AU - Bao, Wenjun AU - Richard, Ann AU - Tong, Weida AU - Bushel, Pierre R AU - Brown, Roger AU - Bruno, Maribel AU - Cunningham, Michael L AU - Dix, David AU - Eastin, William AU - Frade, Carlos AU - Garcia, Alex AU - Heinloth, Alexandra AU - Irwin, Rick AU - Madenspacher, Jennifer AU - Merrick, B Alex AU - Papoian, Thomas AU - Paules, Richard AU - Rocca-Serra, Philippe AU - Sansone, Assunta-Susanna AU - Stevens, James AU - Tomer, Kenneth AU - Yang, Chihae AU - Waters, Michael AD - LIMT Lockheed Martin Information Technology (LMIT), Research Triangle Park, NC 27709, USA. fostel@niehs.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 585 EP - 601 VL - 88 IS - 2 SN - 1096-6080, 1096-6080 KW - Acetaminophen KW - 362O9ITL9D KW - Index Medicus KW - Administration, Oral KW - Animals KW - Dose-Response Relationship, Drug KW - Proteomics KW - Toxicity Tests KW - Toxicogenetics KW - Acetaminophen -- toxicity KW - Biomedical Research KW - Systems Biology -- methods KW - Databases, Factual KW - Terminology as Topic KW - Research Design KW - Database Management Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68792840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Chemical+effects+in+biological+systems--data+dictionary+%28CEBS-DD%29%3A+a+compendium+of+terms+for+the+capture+and+integration+of+biological+study+design+description%2C+conventional+phenotypes%2C+and+%27omics+data.&rft.au=Fostel%2C+Jennifer%3BChoi%2C+Danielle%3BZwickl%2C+Craig%3BMorrison%2C+Norman%3BRashid%2C+Asif%3BHasan%2C+Atif%3BBao%2C+Wenjun%3BRichard%2C+Ann%3BTong%2C+Weida%3BBushel%2C+Pierre+R%3BBrown%2C+Roger%3BBruno%2C+Maribel%3BCunningham%2C+Michael+L%3BDix%2C+David%3BEastin%2C+William%3BFrade%2C+Carlos%3BGarcia%2C+Alex%3BHeinloth%2C+Alexandra%3BIrwin%2C+Rick%3BMadenspacher%2C+Jennifer%3BMerrick%2C+B+Alex%3BPapoian%2C+Thomas%3BPaules%2C+Richard%3BRocca-Serra%2C+Philippe%3BSansone%2C+Assunta-Susanna%3BStevens%2C+James%3BTomer%2C+Kenneth%3BYang%2C+Chihae%3BWaters%2C+Michael&rft.aulast=Fostel&rft.aufirst=Jennifer&rft.date=2005-12-01&rft.volume=88&rft.issue=2&rft.spage=585&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Research strategies for safety evaluation of nanomaterials, Part III: nanoscale technologies for assessing risk and improving public health. AN - 68787783; 16162851 AB - Risk assessment in the environmental health sciences focuses on understanding the nature of environmental exposures and the potential harm posed by those exposures which in turn is determined by the perturbation of biological pathways and the individual's susceptibility to damage. While there are extensive research efforts ongoing in these areas, progress in each is currently slowed by technological limitations including comprehensive assessment of multiple exposures in real time and dynamic assessment of biological response with high temporal and quantitative resolution. This Forum article discusses recent technological innovations capitalizing on the emergent properties of nanoscale materials and their potential adaptation to improving individual exposure assessment, determination of biological response, and environmental remediation. The ultimate goal is to raise the environmental health science community's awareness of these possibilities and encourage the development of improved strategies for assessing risk and improving public health. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Balshaw, David M AU - Philbert, Martin AU - Suk, William A AD - Center for Risk and Integrated Sciences, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Balshaw@niehs.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 298 EP - 306 VL - 88 IS - 2 SN - 1096-6080, 1096-6080 KW - Environmental Pollutants KW - 0 KW - Index Medicus KW - Biomedical Research KW - Humans KW - Public Health KW - Environmental Pollutants -- toxicity KW - Risk Assessment -- methods KW - Environmental Monitoring -- methods KW - Environmental Health -- methods KW - Nanotechnology KW - Environmental Monitoring -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68787783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Research+strategies+for+safety+evaluation+of+nanomaterials%2C+Part+III%3A+nanoscale+technologies+for+assessing+risk+and+improving+public+health.&rft.au=Balshaw%2C+David+M%3BPhilbert%2C+Martin%3BSuk%2C+William+A&rft.aulast=Balshaw&rft.aufirst=David&rft.date=2005-12-01&rft.volume=88&rft.issue=2&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-10 N1 - Date created - 2005-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Telomeres, telomerase and oral cancer (Review). AN - 68772503; 16273215 AB - Oral squamous cell carcinoma (oral cancer) and many squamous cell carcinomas of the head and neck arise as a consequence of multiple molecular events induced by the effects of various carcinogens related to tobacco use, environmental factors, and viruses in some instances (e.g., mucosal oncogenic human papillomaviruses), against a background of inheritable resistance or susceptibility. Consequent genetic damage affects many chromosomes and genes, and it is the accumulation of these changes that appears to lead to carcinoma. Telomere maintenance by telomerase or, in its absence, alternative lengthening of telomeres protect this acquired altered genetic information ensuring immortality without losing eukaryotic linear DNA; when this does not occur DNA is lost and end-replication problems arise. Telomerase is reactivated in 80-90% of cancers thus attracting the attention of pathologists and clinicians who have explored its use as a target for anticancer therapy and to develop better diagnostic and prognostic markers. In the last few years, valuable research from various laboratories has provided major insights into telomerase and telomeres leading to their use as diagnostic and prognostic markers in several types of cancer. Moreover, many strategies have emerged which inhibit this complex enzyme for anticancer therapy and are one step ahead of clinical trials. This review explains the basic biology and the clinical implications of telomerase-based diagnosis and prognosis, the prospects for its use in anticancer therapy, and the limitations it presents in the context of oral cancer. JF - International journal of oncology AU - Sebastian, Sinto AU - Grammatica, Luciano AU - Paradiso, Angelo AD - Clinical Experimental Oncology Laboratory, Surgery Department, National Cancer Institute, 70126 Bari, Italy. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1583 EP - 1596 VL - 27 IS - 6 SN - 1019-6439, 1019-6439 KW - Telomerase KW - EC 2.7.7.49 KW - Index Medicus KW - Humans KW - Prognosis KW - Models, Biological KW - Mouth Neoplasms -- therapy KW - Telomere -- genetics KW - Mouth Neoplasms -- enzymology KW - Telomerase -- metabolism KW - Mouth Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68772503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+oncology&rft.atitle=Telomeres%2C+telomerase+and+oral+cancer+%28Review%29.&rft.au=Sebastian%2C+Sinto%3BGrammatica%2C+Luciano%3BParadiso%2C+Angelo&rft.aulast=Sebastian&rft.aufirst=Sinto&rft.date=2005-12-01&rft.volume=27&rft.issue=6&rft.spage=1583&rft.isbn=&rft.btitle=&rft.title=International+journal+of+oncology&rft.issn=10196439&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-03 N1 - Date created - 2005-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Thoracic radiation therapy and concomitant low-dose daily paclitaxel in non-small cell lung cancer: a phase I study. AN - 68770255; 16273271 AB - The primary objective of the current study was to determine the maximum tolerated dose of paclitaxel (PTX) that could be added daily to radiation therapy (RT) in patients with non-small cell lung cancer (NSCLC). The secondary objective was to achieve a plasma concentration of PTX estimated to exert a radiosensitizing effect. Eighteen patients with locally advanced NSCLC were treated. 60 Gy of RT were given in 2 Gy fractions, 5 days per week. A daily dose of PTX was delivered by 4-h i.v. infusion before RT. The initial dose level of PTX was 9 mg/m2/day, escalated by 1 mg at each additional patient triplet. Two out of 6 patients experienced acute dose limiting toxicity (DLT) at the 12 mg/m2/day PTX dose level. PTX continuously greater than 10 nM, the estimated radiosensitizing condition, was achieved at the PTX dose level of 12 mg/m2/day. PTX at doses up to 11 mg/m2/day may be safely added to a conventional conformal RT course. Both DLT and the estimated radiosensitizing plasma exposure to PTX were encountered at the 12 mg/m(2)/day dose level. JF - Oncology reports AU - Gobitti, Carlo AU - Franchin, Giovanni AU - Minatel, Emilio AU - Gigante, Marco AU - Basso, Barbara AU - Bujor, Laurentiu AU - Trovò, Mauro G AD - Radiation Oncology Department, Centro di Riferimento Oncologico, National Cancer Institute, 33081 Aviano, Italy. cgobitti@cro.it Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1647 EP - 1653 VL - 14 IS - 6 SN - 1021-335X, 1021-335X KW - Antineoplastic Agents, Phytogenic KW - 0 KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Area Under Curve KW - Infusions, Intravenous KW - Combined Modality Therapy KW - Dose-Response Relationship, Drug KW - Humans KW - Antineoplastic Agents, Phytogenic -- blood KW - Aged KW - Chromatography, High Pressure Liquid KW - Radiotherapy Dosage KW - Antineoplastic Agents, Phytogenic -- therapeutic use KW - Treatment Outcome KW - Middle Aged KW - Antineoplastic Agents, Phytogenic -- administration & dosage KW - Female KW - Male KW - Survival Analysis KW - Paclitaxel -- administration & dosage KW - Lung Neoplasms -- radiotherapy KW - Paclitaxel -- pharmacokinetics KW - Lung Neoplasms -- drug therapy KW - Paclitaxel -- therapeutic use KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Lung Neoplasms -- pathology KW - Carcinoma, Non-Small-Cell Lung -- radiotherapy KW - Carcinoma, Non-Small-Cell Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68770255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology+reports&rft.atitle=Thoracic+radiation+therapy+and+concomitant+low-dose+daily+paclitaxel+in+non-small+cell+lung+cancer%3A+a+phase+I+study.&rft.au=Gobitti%2C+Carlo%3BFranchin%2C+Giovanni%3BMinatel%2C+Emilio%3BGigante%2C+Marco%3BBasso%2C+Barbara%3BBujor%2C+Laurentiu%3BTrov%C3%B2%2C+Mauro+G&rft.aulast=Gobitti&rft.aufirst=Carlo&rft.date=2005-12-01&rft.volume=14&rft.issue=6&rft.spage=1647&rft.isbn=&rft.btitle=&rft.title=Oncology+reports&rft.issn=1021335X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-09 N1 - Date created - 2005-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nitric oxide regulates prolidase activity by serine/threonine phosphorylation. AN - 68766098; 16167338 AB - Prolidase [E.C. 3.4.13.9], a member of the matrix metalloproteinase (MMP) family, is a manganese-dependent cytosolic exopeptidase that cleaves imidodipeptides containing C-terminal proline or hydroxyproline. It plays an important role in collagen metabolism, matrix remodeling and cell growth. Nitric oxide (NO), a versatile signaling molecule, regulates many processes including collagen synthesis and matrix remodeling and, thereby, may modulate angiogenesis, tumor invasiveness, and metastasis. Thus, we considered that prolidase may be an important target of NO regulation. In our study, SIN I and DETA/NO were used as NO donors. Both donors increased prolidase activity in a time-dependent and dose-dependent manner. Prolidase activity increased not only with NO donors but also with endogenous NO in cells transfected with iNOS. The effect of iNOS was abolished by treatment with S-methylisothiourea (SMT), a selective inhibitor of iNOS. However, with either exogenous or endogenous sources of NO, the increase in prolidase activity was not accompanied by increased prolidase expression. Therefore, we suspected phosphorylation of prolidase as a potential mechanism regulating enzyme activation. We observed increased serine/threonine phosphorylation on prolidase protein in cells treated with NO donors and in cells transfected with iNOS. To determinate the pathways that may mediate prolidase induction by NO, we first used 8-Br-cGMP, a cGMP agonist, and found that 8-Br-cGMP strongly and rapidly stimulated prolidase activity accompanied by increased phosphorylation. Rp-8-Br-pCPT-cGMP, an inhibitor of cGMP, reduced NO donor-stimulated prolidase activity to control levels. To test whether the MAPK pathway is involved in this NO-dependent activation, we used an ERK1/2 inhibitor and found that it had no effect on prolidase activity increased by NO donors. These results demonstrate that NO stimulates prolidase activity by increasing serine/threonine phosphorylation through PKG-cGMP pathway, but independent of MAPK and suggest an interaction between inflammatory signaling pathways and regulation of the terminal step of matrix degradation. 2005 Wiley-Liss, Inc. JF - Journal of cellular biochemistry AU - Surazynski, Arkadiusz AU - Liu, Yongmin AU - Miltyk, Wojciech AU - Phang, James M AD - Metabolism and Cancer Susceptibility Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. Y1 - 2005/12/01/ PY - 2005 DA - 2005 Dec 01 SP - 1086 EP - 1094 VL - 96 IS - 5 SN - 0730-2312, 0730-2312 KW - DNA, Complementary KW - 0 KW - Peptides KW - Threonine KW - 2ZD004190S KW - Nitric Oxide KW - 31C4KY9ESH KW - Serine KW - 452VLY9402 KW - Nitric Oxide Synthase Type II KW - EC 1.14.13.39 KW - Mitogen-Activated Protein Kinase 1 KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinase 3 KW - Dipeptidases KW - EC 3.4.13.- KW - proline dipeptidase KW - EC 3.4.13.9 KW - Matrix Metalloproteinases KW - EC 3.4.24.- KW - Thiourea KW - GYV9AM2QAG KW - Cyclic GMP KW - H2D2X058MU KW - Index Medicus KW - Animals KW - Plasmids -- metabolism KW - Dose-Response Relationship, Drug KW - Wound Healing KW - Immunoprecipitation KW - Mice KW - NIH 3T3 Cells KW - Inflammation KW - Mitogen-Activated Protein Kinase 3 -- metabolism KW - Blotting, Western KW - Cyclic GMP -- metabolism KW - Phosphorylation KW - Transfection KW - Matrix Metalloproteinases -- chemistry KW - DNA, Complementary -- metabolism KW - Mitogen-Activated Protein Kinase 1 -- metabolism KW - Peptides -- chemistry KW - Nitric Oxide Synthase Type II -- metabolism KW - Neovascularization, Pathologic KW - Thiourea -- chemistry KW - Time Factors KW - Signal Transduction KW - Dipeptidases -- biosynthesis KW - Threonine -- chemistry KW - Gene Expression Regulation, Enzymologic KW - Nitric Oxide -- metabolism KW - Dipeptidases -- chemistry KW - Serine -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68766098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=9th+International+Workshop+on+Langerhans+Cells+%28LC+2005%29&rft.atitle=Induction+of+a+Graft-Versus-Host-Like+Skin+Disease+by+Intradermal+Injection+of+Ovalbumin-Peptide-Specific+CD8%2B+%28OT-I%29+T+Cells+into+Keratin+14-Ovalbumin-Expressing+Transgenic+Mice&rft.au=Kim%2C+B+S%3BMiyagawa%2C+F%3BKatz%2C+S+I&rft.aulast=Kim&rft.aufirst=B&rft.date=2005-09-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=9th+International+Workshop+on+Langerhans+Cells+%28LC+2005%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-03-20 N1 - Date created - 2005-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), in rats and dogs: potential clinical relevance. AN - 68658649; 15986212 AB - 17-DMAG is a hydrophilic derivative of the molecular chaperone inhibitor 17-(allylamino)-17-demethoxygeldanamycin (17-AAG; NSC-330507), which is currently being evaluated for the treatment of cancer in clinical trials. 17-DMAG offers a potential advantage over 17-AAG because its aqueous solubility eliminates the need for complicated formulations that are currently used for administration of 17-AAG. In addition, 17-DMAG undergoes only limited metabolism compared to 17-AAG. The present results are from preclinical toxicity studies evaluating 17-DMAG in rats and dogs. Doses of 0, 2.4, 12 and 24 mg/m2 per day were administered to rats, while dogs received doses of 0, 8 or 16 mg/m2 per day. In both species, 17-DMAG was administered i.v. (slow bolus for rats; 1-h infusion for dogs) daily for 5 days. An additional cohort of dogs received 16 mg/m2 per day orally for 5 days. Clinical observations were noted, and standard hematology and clinical chemistry parameters were monitored. Selected tissues were evaluated microscopically for drug-related lesions. Tissue and plasma 17-DMAG concentrations were measured by HPLC/MS at selected time-points on days 1 and 5. Daily i.v. administration of 17-DMAG at doses of 24 mg/m2 per day in rats or 16 mg/m2 per day in dogs produced lethality on day 6, approximately 24 h following the last dose. Body weight loss was common in rats and dogs. Drug-related gastrointestinal, bone marrow and hepatic toxicities were also common in rats and dogs. Dogs also exhibited signs of renal and gallbladder toxicity. Plasma concentrations of 17-DMAG increased proportionately with dose in rats and disproportionately with dose in dogs. In rat tissues, however, only fourfold to sixfold increases in 17-DMAG concentrations were observed with a tenfold increase in dose. The highest concentrations of 17-DMAG were found in the liver of rats, with progressively lower concentrations in the spleen, lung, kidney and plasma. Regardless of the route of administration, higher drug concentrations were present in plasma (rat and dog) and tissue (rat) samples obtained on day 5 compared to those obtained on day 1. Although plasma concentrations decreased with time, 17-DMAG was still detected in dog plasma for at least 24 h after drug administration. With the recent approval of 17-DMAG for clinical use, the data generated from these preclinical studies will provide guidance to clinicians as they administer this drug to their patients. The MTD of 17-DMAG was 12 mg/m2 per day in rats and 8 mg/m2 per day in dogs; therefore, the recommended starting dose for phase I trial is 1.3 mg/m2 per day for 5 days. Gastrointestinal and bone marrow toxicity were dose-limiting in rats, and gastrointestinal, renal, gallbladder and bone marrow toxicity were dose-limiting in dogs. All adverse effects were fully reversible in surviving animals after treatment was complete. JF - Cancer chemotherapy and pharmacology AU - Glaze, Elizabeth R AU - Lambert, Amy L AU - Smith, Adaline C AU - Page, John G AU - Johnson, William D AU - McCormick, David L AU - Brown, Alan P AU - Levine, Barry S AU - Covey, Joseph M AU - Egorin, Merrill J AU - Eiseman, Julie L AU - Holleran, Julianne L AU - Sausville, Edward A AU - Tomaszewski, Joseph E AD - Toxicology and Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Executive Plaza North, Room 8040, Rockville, MD 20852, USA. glazee@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 637 EP - 647 VL - 56 IS - 6 SN - 0344-5704, 0344-5704 KW - Antibiotics, Antineoplastic KW - 0 KW - Benzoquinones KW - Lactams, Macrocyclic KW - Quinones KW - 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin KW - 001L2FE0M3 KW - geldanamycin KW - Z3K3VJ16KU KW - Index Medicus KW - Animals KW - Recovery of Function KW - Rats KW - Rats, Inbred F344 KW - Gastrointestinal Tract -- drug effects KW - Clinical Chemistry Tests KW - Bone Marrow -- drug effects KW - Male KW - Administration, Oral KW - Bone Marrow -- pathology KW - Kidney -- pathology KW - Infusions, Intravenous KW - Injections, Intravenous KW - Dose-Response Relationship, Drug KW - Longevity -- drug effects KW - Kidney -- drug effects KW - Gallbladder -- drug effects KW - Hematologic Tests KW - Gastrointestinal Tract -- pathology KW - Body Weight -- drug effects KW - Toxicity Tests KW - Dogs KW - Species Specificity KW - Gallbladder -- pathology KW - Female KW - Quinones -- pharmacokinetics KW - Quinones -- toxicity KW - Antibiotics, Antineoplastic -- pharmacokinetics KW - Antibiotics, Antineoplastic -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68658649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=Preclinical+toxicity+of+a+geldanamycin+analog%2C+17-%28dimethylaminoethylamino%29-17-demethoxygeldanamycin+%2817-DMAG%29%2C+in+rats+and+dogs%3A+potential+clinical+relevance.&rft.au=Glaze%2C+Elizabeth+R%3BLambert%2C+Amy+L%3BSmith%2C+Adaline+C%3BPage%2C+John+G%3BJohnson%2C+William+D%3BMcCormick%2C+David+L%3BBrown%2C+Alan+P%3BLevine%2C+Barry+S%3BCovey%2C+Joseph+M%3BEgorin%2C+Merrill+J%3BEiseman%2C+Julie+L%3BHolleran%2C+Julianne+L%3BSausville%2C+Edward+A%3BTomaszewski%2C+Joseph+E&rft.aulast=Glaze&rft.aufirst=Elizabeth&rft.date=2005-12-01&rft.volume=56&rft.issue=6&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=03445704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-05 N1 - Date created - 2005-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Homozygous germ line mutation in exon 27 of murine Brca2 disrupts the Fancd2-Brca2 pathway in the homologous recombination-mediated DNA interstrand cross-links' repair but does not affect meiosis. AN - 68642130; 16127665 AB - The role of the region encoded by exon 27 of the Brca2 gene in DNA repair was studied in cells and tissues from Brca2Delta27/Delta27 mice. The COOH-terminal truncated Brca2 localized to the nucleus in primary mouse embryo fibroblasts from Brca2Delta27/Delta27 mice. Fluorescence-activated cell sorting (FACS) analysis demonstrated that these fibroblasts were hypersensitive to mitomycin C-induced cross-links, but not to double-strand breaks (DSBs) induced by irradiation. The gammaH2AX appearance kinetics and comet assay showed that DSBs were repaired through non-homologous end joining pathways, while interstrand cross-links were not repaired due to deficient homologous recombination pathways. Immunoprecipitation experiments showed that Fancd2 did not coprecipitate with the mutated Brca2. There were also no detectable Rad51-positive foci formed in these cells after damage. On the other hand, we did not find any difference during gametogenesis in mice harboring exon 27 truncating mutation of the Brca2 gene and control mice, and in both cases, Rad51 localized to the recombination foci. Our results suggest that exon 27 of murine Brca2 is crucial for the interaction of Brca2 and Fancd2 in Rad51-mediated recombination in response to DNA damage, but that this interaction is not taking place in the homologous recombination during meiosis. Published 2005 Wiley-Liss, Inc. JF - Genes, chromosomes & cancer AU - Atanassov, Boyko S AU - Barrett, J Carl AU - Davis, Barbara J AD - Laboratory of Women's Health, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 429 EP - 437 VL - 44 IS - 4 SN - 1045-2257, 1045-2257 KW - BRCA2 Protein KW - 0 KW - Fanconi Anemia Complementation Group D2 Protein KW - Histones KW - gamma-H2AX protein, mouse KW - Mitomycin KW - 50SG953SK6 KW - Rad51 Recombinase KW - EC 2.7.7.- KW - Rad51 protein, mouse KW - Index Medicus KW - Animals KW - Comet Assay KW - Fibroblasts -- drug effects KW - Cell Nucleus -- metabolism KW - Exons KW - Fluorescent Antibody Technique, Indirect KW - Mitomycin -- pharmacology KW - Mice KW - Rad51 Recombinase -- metabolism KW - Blotting, Western KW - Cells, Cultured KW - Kinetics KW - Histones -- metabolism KW - Fibroblasts -- radiation effects KW - Flow Cytometry KW - Embryo, Mammalian KW - Female KW - Radiation, Ionizing KW - DNA Repair KW - BRCA2 Protein -- chemistry KW - Meiosis KW - Recombination, Genetic KW - Fanconi Anemia Complementation Group D2 Protein -- metabolism KW - BRCA2 Protein -- metabolism KW - Germ-Line Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68642130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genes%2C+chromosomes+%26+cancer&rft.atitle=Homozygous+germ+line+mutation+in+exon+27+of+murine+Brca2+disrupts+the+Fancd2-Brca2+pathway+in+the+homologous+recombination-mediated+DNA+interstrand+cross-links%27+repair+but+does+not+affect+meiosis.&rft.au=Atanassov%2C+Boyko+S%3BBarrett%2C+J+Carl%3BDavis%2C+Barbara+J&rft.aulast=Atanassov&rft.aufirst=Boyko&rft.date=2005-12-01&rft.volume=44&rft.issue=4&rft.spage=429&rft.isbn=&rft.btitle=&rft.title=Genes%2C+chromosomes+%26+cancer&rft.issn=10452257&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-06 N1 - Date created - 2005-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Modulation of cytochrome P450 enzymes by organosulfur compounds from garlic. AN - 68622945; 16000231 AB - Organosulfur compounds (OSCs) derived from garlic have been studied for the ability to inhibit experimental cancer in various animal models, primarily through modification of carcinogen detoxification enzymes, such as cytochrome P450 (CYP) enzymes. OSCs vary in structural and physical properties, and a detailed analysis of these properties has not been performed with respect to their ability of inhibit chemically-induced colon cancer development. Gastric intubation of rats with a single dose of 200 mg/kg diallyl sulfide (DAS), diallyl disulfide (DADS), and allyl methyl sulfide (AMS) decreased hepatic CYP2E1 protein by 45%, 25% and 47%, respectively, and this inhibition was sustained after 1, 4 and 8 weeks of treatment by these compounds. Dipropyl sulfide (DPS), dipropyl disulfide (DPDS), propyl methyl sulfide (PMS) and S-allylcysteine (SAC) did not inhibit hepatic CYP2E1 protein expression, nor did any of the OSCs affect CYP2E1 mRNA levels. A single dose of 200 mg/kg DAS and AMS increased hepatic CYP1A2 protein (but not mRNA) by 282% and 70%, and DAS increased CYP1A1 protein levels by 684%. Daily treatment for 1, 4 and 8 weeks with 200 mg/kg DAS and AMS resulted in time-dependent increases in hepatic CYP1A1 and CYP1A2 protein levels to a maximum of 600% and 50% for DAS, and 1600% and 240% for AMS after 8 weeks. Dosing with 200 mg/kg of each of the OSCs used in this study increased hepatic CYP3A2 protein levels at all time points. Dosing for 8 weeks with 200 mg/kg DAS, but not AMS or lower doses of DAS, induced bile duct obstruction and focal areas of necrosis. These results indicate that OSCs present in garlic, including DAS and AMS, may be beneficial in inhibiting chemically-induced colon cancer, but that longer dosing with higher concentrations of DAS may elicit minor hepatic toxicity. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Davenport, Destiny M AU - Wargovich, Michael J AD - Department of Pathology and Microbiology, University of South Carolina, School of Medicine and South Carolina Cancer Center, Columbia, SC 29208, USA. matthew2@niehs.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1753 EP - 1762 VL - 43 IS - 12 SN - 0278-6915, 0278-6915 KW - Allyl Compounds KW - 0 KW - Anticarcinogenic Agents KW - Disulfides KW - Sulfides KW - Sulfur Compounds KW - diallyl disulfide KW - 5HI47O6OA7 KW - allyl sulfide KW - 60G7CF7CWZ KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP1A2 KW - allyl methyl sulfide KW - V7QI1R316C KW - Index Medicus KW - Animals KW - Random Allocation KW - Dose-Response Relationship, Drug KW - Disulfides -- pharmacology KW - Cytochrome P-450 CYP1A2 -- metabolism KW - Allyl Compounds -- pharmacology KW - Cytochrome P-450 CYP1A1 -- metabolism KW - Cytochrome P-450 CYP2E1 -- metabolism KW - Allyl Compounds -- toxicity KW - Rats KW - Cytochrome P-450 CYP1A2 -- drug effects KW - Rats, Inbred F344 KW - Carcinogenicity Tests KW - Sulfides -- toxicity KW - Time Factors KW - Sulfides -- pharmacology KW - Cytochrome P-450 CYP2E1 -- drug effects KW - Male KW - Disulfides -- toxicity KW - Cytochrome P-450 CYP1A1 -- drug effects KW - Anticarcinogenic Agents -- toxicity KW - Liver -- pathology KW - Liver -- enzymology KW - Sulfur Compounds -- toxicity KW - Sulfur Compounds -- pharmacology KW - Liver -- drug effects KW - Anticarcinogenic Agents -- pharmacology KW - Cytochrome P-450 Enzyme System -- metabolism KW - Cytochrome P-450 Enzyme System -- drug effects KW - Garlic -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68622945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=22nd+Annual+Scientific+Meeting+of+the+European+Society+for+Magnetic+Resonance+in+Medicine+and+Biology+%28ESMRMB+2005%29&rft.atitle=Regional+Strain+Mapping+of+the+Carotid+Artery+Wall+in+Humans+Using+DENSE&rft.au=Wen%2C+H%3BVignaud%2C+A%3BRodriguez%2C+I&rft.aulast=Wen&rft.aufirst=H&rft.date=2005-09-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=22nd+Annual+Scientific+Meeting+of+the+European+Society+for+Magnetic+Resonance+in+Medicine+and+Biology+%28ESMRMB+2005%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-29 N1 - Date created - 2005-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Signal transduction during environmental stress: InsP8 operates within highly restricted contexts. AN - 68572328; 15936174 AB - Genetic manipulation of diphosphoinositol polyphosphate synthesis impacts many biological processes (reviewed in S.B. Shears, Biochem. J. 377, 2004, 265-280). These observations lacked a cell-signalling context, until the recent discovery that bis-diphosphoinositol tetrakisphosphate ([PP]2-InsP4 or "InsP8") accumulates rapidly in mammalian cells in response to hyperosmotic stress (X. Pesesse, K. Choi, T. Zhang, and S. B. Shears J. Biol. Chem. 279, 2004, 43378-43381). We now investigate how widely applicable is this new stress-response. [PP]2-InsP4 did not respond to mechanical strain or oxidative stress in mammalian cells. Furthermore, despite tight conservation of many molecular stress responses across the phylogenetic spectrum, we show that cellular [PP]2-InsP4 levels do not respond significantly to osmotic imbalance, heat stress and salt toxicity in Saccharomyces cerevisiae. In contrast, we show that [PP]2-InsP4 is a novel sensor of mild thermal stress in mammalian cells: [PP]2-InsP4 levels increased 3-4 fold when cells were cooled from 37 to 33 degrees C, or heated to 42 degrees C. Increases in [PP]2-InsP4 levels following heat-shock were evident <5 min, and reversible (t(1/2)=7 min) once cells were returned to 37 degrees C. These responses were blocked by pharmacological inhibition of the ERK/MEK pathway. Additional control processes may lie upstream of [PP]2-InsP4 synthesis, which was synergistically activated when heat stress and osmotic stress were combined. Our data add to the repertoire of signaling responses following thermal challenges, a topic of current interest for its possible therapeutic value. JF - Cellular signalling AU - Choi, Kuicheon AU - Mollapour, Elahe AU - Shears, Stephen B AD - Inositide Signaling Group, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, PO Box 12233, NC 27709, USA. Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 1533 EP - 1541 VL - 17 IS - 12 SN - 0898-6568, 0898-6568 KW - Saccharomyces cerevisiae Proteins KW - 0 KW - p38 Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - MAP Kinase Kinase Kinases KW - EC 2.7.11.25 KW - Phosphotransferases (Phosphate Group Acceptor) KW - EC 2.7.4.- KW - KCS1 protein, S cerevisiae KW - EC 2.7.4.21 KW - Acid Anhydride Hydrolases KW - EC 3.6.- KW - diphosphoinositol polyphosphate phosphohydrolase KW - EC 3.6.1.- KW - Index Medicus KW - Saccharomyces cerevisiae Proteins -- metabolism KW - Animals KW - Osmotic Pressure KW - Saccharomyces cerevisiae Proteins -- genetics KW - Heat-Shock Response KW - Humans KW - Saccharomyces cerevisiae -- enzymology KW - Myocytes, Smooth Muscle -- metabolism KW - p38 Mitogen-Activated Protein Kinases -- metabolism KW - Saccharomyces cerevisiae -- genetics KW - MAP Kinase Kinase Kinases -- metabolism KW - MAP Kinase Kinase Kinases -- antagonists & inhibitors KW - p38 Mitogen-Activated Protein Kinases -- antagonists & inhibitors KW - Stress, Mechanical KW - Oxidative Stress KW - Phosphotransferases (Phosphate Group Acceptor) -- metabolism KW - Keratinocytes -- metabolism KW - Phosphotransferases (Phosphate Group Acceptor) -- genetics KW - Cell Line KW - Cricetinae KW - MAP Kinase Signaling System KW - Acid Anhydride Hydrolases -- metabolism KW - Signal Transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68572328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+signalling&rft.atitle=Signal+transduction+during+environmental+stress%3A+InsP8+operates+within+highly+restricted+contexts.&rft.au=Choi%2C+Kuicheon%3BMollapour%2C+Elahe%3BShears%2C+Stephen+B&rft.aulast=Choi&rft.aufirst=Kuicheon&rft.date=2005-12-01&rft.volume=17&rft.issue=12&rft.spage=1533&rft.isbn=&rft.btitle=&rft.title=Cellular+signalling&rft.issn=08986568&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-04 N1 - Date created - 2005-09-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Relationships between Childhood Sexual Abuse, Social Anxiety, and Symptoms of Posttraumatic Stress Disorder in Women AN - 60002281; 200614125 AB - The relationships between childhood sexual abuse, social anxiety, & symptoms of posttraumatic stress disorder were examined in a sample of 313 undergraduate women. Thirty-one percent of the women reported some form of sexual abuse in childhood. Women with a history of sexual abuse reported more symptoms of anxiety, distress in social situations, & posttraumatic stress disorder than other women. Women who experienced attempted or actual intercourse reported more avoidance than women with no history of abuse & women with exposure only, & more PTSD symptoms than all other groups of women. Women who experienced fondling reported more PTSD symptoms than women with no history of abuse. Pressure, age of onset of abuse, abuse by a family friend, & abuse by other perpetrators were all significant abuse characteristics in predicting adult social anxiety. Implications of these results for research & interventions are discussed. Tables, References. Adapted from the source document. JF - Journal of Family Violence AU - Feerick, Margaret M AU - Snow, Kyle L AD - National Instit Child Health & Human Development, National Instit Health, Bethesda, MD feerickm@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 409 EP - 419 PB - Springer Science+Business Media, Inc, New York, NY VL - 20 IS - 6 SN - 0885-7482, 0885-7482 KW - childhood sexual abuse KW - long-term effects KW - social anxiety KW - PTSD KW - Symptoms KW - Anxiety KW - Females KW - Posttraumatic Stress Disorder KW - Child Sexual Abuse KW - article KW - 2190: social problems and social welfare; victimology (rape, family violence, & child abuse) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/60002281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Family+Violence&rft.atitle=The+Relationships+between+Childhood+Sexual+Abuse%2C+Social+Anxiety%2C+and+Symptoms+of+Posttraumatic+Stress+Disorder+in+Women&rft.au=Feerick%2C+Margaret+M%3BSnow%2C+Kyle+L&rft.aulast=Feerick&rft.aufirst=Margaret&rft.date=2005-12-01&rft.volume=20&rft.issue=6&rft.spage=409&rft.isbn=&rft.btitle=&rft.title=Journal+of+Family+Violence&rft.issn=08857482&rft_id=info:doi/10.1007%2Fs10896-005-7802-z LA - English DB - Sociological Abstracts N1 - Date revised - 2007-04-01 N1 - Number of references - 81 N1 - Last updated - 2016-09-28 N1 - CODEN - JFVIEV N1 - SubjectsTermNotLitGenreText - Females; Child Sexual Abuse; Anxiety; Posttraumatic Stress Disorder; Symptoms DO - http://dx.doi.org/10.1007/s10896-005-7802-z ER - TY - JOUR T1 - Physician Migration: Views from Professionals in Colombia, Nigeria, India, Pakistan and the Philippines AN - 57185034; 200610160 AB - There has been much debate recently about several issues related to the migration of physicians from developing to developed countries. However, few studies have been conducted to address these issues in a systematic fashion. In an attempt to begin the process of generating systematic data, we designed & distributed a questionnaire addressing several core issues surrounding physician migration to respondents selected on the basis of their special expertise or experience in India, Nigeria, Pakistan, Colombia, & the Philippines. The issues addressed relate to the reasons physicians migrate to developed countries, how migration is related to the structure of medical education, the effect that migration has on the health care infrastructure of developing countries, & various policy options for dealing with physician migration. Though responses varied somewhat by country, a desire for increased income, greater access to enhanced technology, an atmosphere of general security & stability, & improved prospects for one's children were the primary motivating factors for physician migration. A majority of respondents believed that physicians in developing counties are provided with highly specialized skills that they can better utilize in developed countries, but respondents were ambivalent with respect to the utility of educational reform. Responses varied significantly by country with regard to whether physician migration results in physician shortages, but there was widespread agreement that it exacerbates shortages in rural & public settings. With respect to policy options, increasing physician income, improving working conditions, requiring physicians to work in their home countries for a period following graduation from medical school, & creating increased collaboration between health ministries in developed & developing countries found the most favor with respondents. 4 Tables, 27 References. [Copyright 2005 Elsevier Ltd.] JF - Social Science & Medicine AU - Astor, Avraham AU - Akhtar, Tasleem AU - Matallana, Maria Alexandra AU - Muthuswamy, Vasantha AU - Olowu, Folarin A AU - Tallo, Veronica AU - Lie, Reidar K AD - c/o Lie -- Dept Clinical Bioethics, National Instit Health, Bethesda, MD Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 2492 EP - 2500 PB - Elsevier Science, Amsterdam The Netherlands VL - 61 IS - 12 SN - 0277-9536, 0277-9536 KW - Physician migration KW - Health policy KW - Developing countries KW - India KW - Pakistan KW - Nigeria KW - Columbia KW - The Philippines KW - Doctors KW - Migration KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57185034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=Physician+Migration%3A+Views+from+Professionals+in+Colombia%2C+Nigeria%2C+India%2C+Pakistan+and+the+Philippines&rft.au=Astor%2C+Avraham%3BAkhtar%2C+Tasleem%3BMatallana%2C+Maria+Alexandra%3BMuthuswamy%2C+Vasantha%3BOlowu%2C+Folarin+A%3BTallo%2C+Veronica%3BLie%2C+Reidar+K&rft.aulast=Astor&rft.aufirst=Avraham&rft.date=2005-12-01&rft.volume=61&rft.issue=12&rft.spage=2492&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2005.05.003 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-07-28 N1 - Last updated - 2016-09-27 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Doctors; Migration; Health policy; Developing countries DO - http://dx.doi.org/10.1016/j.socscimed.2005.05.003 ER - TY - JOUR T1 - Dysbindin (DTNBP1, 6p22.3) Is Associated with Childhood-Onset Psychosis and Endophenotypes Measured by the Premorbid Adjustment Scale (PAS) AN - 57044953; 200614510 AB - Straub et al. (2002) recently identified the 6p22.3 gene dysbindin (DTNBP1) through positional cloning as a schizophrenia susceptibility gene. We studied a rare cohort of 102 children with onset of psychosis before age 13. Standardized ratings of early development, medication response, neuropsychological & cognitive performance, premorbid dysfunction & clinical follow-up were obtained. Fourteen SNPs were genotyped in the gene DTNBP1. Family-based pairwise & haplotype transmission disequilibrium test (TDT) analysis with the clinical phenotype, & quantitative transmission disequilibrium test (QTDT) explored endophenotype relationships. One SNP was associated with diagnosis (TDT p=.01). The QTDT analyses showed several significant relationships. Four adjacent SNPs were associated (p values=.0009-.003) with poor premorbid functioning. These findings support the hypothesis that this & other schizophrenia susceptibility genes contribute to early neurodevelopmental impairment. 3 Tables, 38 References. Adapted from the source document. JF - Journal of Autism and Developmental Disorders AU - Gornick, M C AU - Addington, A M AU - Sporn, A AU - Gogtay, N AU - Greenstein, D AU - Lenane, M AU - Gochman, P AU - Ordonez, A AU - Balkissoon, R AU - Vakkalanka, R AU - Weinberger, D R AU - Rapoport, J L AU - Straub, R E AD - c/o Rapoport -- Child Psychiatry Branch, IRP, National Instit Mental Health, Bethesda, MD Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 831 EP - 838 PB - Springer, Dordrecht The Netherlands VL - 35 IS - 6 SN - 0162-3257, 0162-3257 KW - Candidate gene KW - genetic association KW - transmission disequilibrium test KW - quantitative TDT KW - schizophrenia KW - DTNBP1 KW - childhood onset KW - Schizophrenia KW - Genetics KW - Phenotypes KW - Psychoses KW - Childhood onset KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57044953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Dysbindin+%28DTNBP1%2C+6p22.3%29+Is+Associated+with+Childhood-Onset+Psychosis+and+Endophenotypes+Measured+by+the+Premorbid+Adjustment+Scale+%28PAS%29&rft.au=Gornick%2C+M+C%3BAddington%2C+A+M%3BSporn%2C+A%3BGogtay%2C+N%3BGreenstein%2C+D%3BLenane%2C+M%3BGochman%2C+P%3BOrdonez%2C+A%3BBalkissoon%2C+R%3BVakkalanka%2C+R%3BWeinberger%2C+D+R%3BRapoport%2C+J+L%3BStraub%2C+R+E&rft.aulast=Gornick&rft.aufirst=M&rft.date=2005-12-01&rft.volume=35&rft.issue=6&rft.spage=831&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/10.1007%2Fs10803-005-0028-3 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-10-02 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDDQ N1 - SubjectsTermNotLitGenreText - Genetics; Psychoses; Phenotypes; Schizophrenia; Childhood onset DO - http://dx.doi.org/10.1007/s10803-005-0028-3 ER - TY - CPAPER T1 - Genetic Marking Studies in Non-Human Primates: Insights into Hematopoiesis and Leukemogenesis T2 - 2005 Euroconference on Gene and Cell Therapy AN - 40099002; 4041880 JF - 2005 Euroconference on Gene and Cell Therapy AU - Dunbar, Cynthia E Y1 - 2005/12/01/ PY - 2005 DA - 2005 Dec 01 KW - Leukemogenesis KW - Hemopoiesis KW - Primates KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40099002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Euroconference+on+Gene+and+Cell+Therapy&rft.atitle=Genetic+Marking+Studies+in+Non-Human+Primates%3A+Insights+into+Hematopoiesis+and+Leukemogenesis&rft.au=Dunbar%2C+Cynthia+E&rft.aulast=Dunbar&rft.aufirst=Cynthia&rft.date=2005-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Euroconference+on+Gene+and+Cell+Therapy&rft.issn=&rft_id=info:doi/ L2 - http://www.pasteur.fr/applications/euroconf/geneandcelltherapy/gene-program me.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Addiction and its brain science AN - 37698390; 3253554 AB - Aims To illustrate how modern neurobiological approaches will help to identify the neurocircuits and genes involved in addictive behavior. Background The current disorder concept of addiction includes neurobiological foundations and neurobiological research assuming irreversible molecular and structural changes within the brain dopamine reinforcement system, constituting the 'molecular and structural switch' from controlled drug intake to compulsive drug abuse. However, those irreversible changes have not so far been identified and it is suggested that in addition to the mesolimbic dopamine system, other brain systems including the mesocortical and nigrostriatal pathways as well as their non-dopaminergic feedback-loops might be involved in addictive behavior. Neurobiological approach A three-step neurobiological approach is described that allows in a first step via novel animal models and imaging techniques to identify the neuroanatomical sites mediating voluntary drug intake, reinstatement of drug-seeking behavior, relapse, loss of control and drug intake despite negative consequences. In a subsequent step, forward genetic approaches including quantitative trait loci (QTL)-analysis and gene expression profiling are helpful in identifying so-called candidate genes. In a final step, conditional animal mutants and selective pharmacological tools are used to functionally validate candidate genes. Following this validation process, the transfer to the human situation has to be made and candidate genes have to be verified further in well-phenotyped cohorts of addicted patients. Conclusion This three-step neurobiological approach, that must involve an interdisciplinary team including experimental psychologists, geneticists, molecular biologists and finally clinical addiction researchers, will allow us to understand where and how the addicted brain goes awry. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Spanagel, Rainer AU - Heilig, Markus AD - University of Heidelberg ; National Institute on Alcohol Abuse and Alcoholism Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1813 EP - 1822 VL - 100 IS - 12 SN - 0965-2140, 0965-2140 KW - Sociology KW - Genetics KW - Behavioural psychology KW - Brain KW - Social problems KW - Health KW - Addiction KW - Drugs KW - Neurology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37698390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Addiction+and+its+brain+science&rft.au=Spanagel%2C+Rainer%3BHeilig%2C+Markus&rft.aulast=Spanagel&rft.aufirst=Rainer&rft.date=2005-12-01&rft.volume=100&rft.issue=12&rft.spage=1813&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2005.01260.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5772; 11893 11979; 561 6220; 1750 1678; 8635; 1540 1543 10404; 3755; 5460 1615 8573 11325 DO - http://dx.doi.org/10.1111/j.1360-0443.2005.01260.x ER - TY - JOUR T1 - Developmental differences in the function and use of anatomical dolls during interviews with alleged sexual abuse victims AN - 36524710; 3315465 AB - The impact of anatomical dolls on reports provided by 3- to 12-year-old alleged sexual abuse victims (N = 178) was examined. Children produced as many details in response to open-ended invitations with and without the dolls. In response to directive questions, the 3- to 6-year-olds were more likely to reenact behaviorally than to report verbally, whereas the 7- to 12-year-olds produced more verbal details than enactments when using the dolls. With the dolls, the younger children were more likely than the older children to play suggestively and to contradict details provided without the dolls, whereas the older children were more likely to provide details that were consistent. Children in both age groups produced proportionally more fantastic details with the dolls than without the dolls. Reprinted by permission of the American Psychological Association JF - Journal of consulting and clinical psychology AU - Thierry, Karen L AU - Lamb, Michael E AU - Orbach, Yael AU - Pipe, Margaret-Ellen AD - State University of New Jersey ; University of Cambridge ; National Institute of Child Health and Human Development Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1125 EP - 1134 VL - 73 IS - 6 SN - 0022-006X, 0022-006X KW - Sociology KW - Body KW - Memory KW - Social psychology KW - Sexual abuse KW - Childhood KW - Behavioural psychology KW - Interviews KW - Psychopathology KW - Anatomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36524710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+consulting+and+clinical+psychology&rft.atitle=Developmental+differences+in+the+function+and+use+of+anatomical+dolls+during+interviews+with+alleged+sexual+abuse+victims&rft.au=Thierry%2C+Karen+L%3BLamb%2C+Michael+E%3BOrbach%2C+Yael%3BPipe%2C+Margaret-Ellen&rft.aulast=Thierry&rft.aufirst=Karen&rft.date=2005-12-01&rft.volume=73&rft.issue=6&rft.spage=1125&rft.isbn=&rft.btitle=&rft.title=Journal+of+consulting+and+clinical+psychology&rft.issn=0022006X&rft_id=info:doi/10.1037%2F0022-006X.73.6.1125 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 10409; 2211 652 5676 646 6091 2212; 1540 1543 10404; 11901 10404; 11559 11540 3015 11881; 7930; 6832 10919; 981 1615 8573 11325; 1678 DO - http://dx.doi.org/10.1037/0022-006X.73.6.1125 ER - TY - JOUR T1 - Evidence for a gene-environment interaction in predicting behavioral inhibition in middle childhood AN - 36488019; 3298343 AB - Gene-environment interactions are presumed to shape human behavior during early development. However, no human research has demonstrated that such interactions lead to stable individual differences in fear responses. We tested this possibility by focusing on a polymorphism in the promoter region of the gene for the serotonin transporter (5-HTT). This polymorphism has been linked to many indices of serotonin activity. Specifically, we tested the hypothesis that an interaction between children's 5-HTT status and maternal reports of social support predicts inhibited behavior with unfamiliar peers in middle childhood. Results were consistent with this hypothesis: Children with the combination of the short 5-HTT allele and low social support had increased risk for behavioral inhibition in middle childhood. Reprinted by permission of Sage Publications JF - Psychological science AU - Fox, Nathan A AU - Nichols, Kate E AU - Henderson, Heather A AU - Rubin, Kenneth AU - Schmidt, Louis AU - Hamer, Dean AU - Ernst, Monique AU - Pine, Daniel S AD - University of Maryland ; University of Miami ; McMaster University ; National Cancer Institute Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 921 EP - 926 VL - 16 IS - 12 SN - 0956-7976, 0956-7976 KW - Sociology KW - Genetics KW - Childhood KW - Behavioural psychology KW - Social environment KW - Psychopathology KW - Developmental psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36488019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+science&rft.atitle=Evidence+for+a+gene-environment+interaction+in+predicting+behavioral+inhibition+in+middle+childhood&rft.au=Fox%2C+Nathan+A%3BNichols%2C+Kate+E%3BHenderson%2C+Heather+A%3BRubin%2C+Kenneth%3BSchmidt%2C+Louis%3BHamer%2C+Dean%3BErnst%2C+Monique%3BPine%2C+Daniel+S&rft.aulast=Fox&rft.aufirst=Nathan&rft.date=2005-12-01&rft.volume=16&rft.issue=12&rft.spage=921&rft.isbn=&rft.btitle=&rft.title=Psychological+science&rft.issn=09567976&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 10409; 11829 6077 4309; 2211 652 5676 646 6091 2212; 1540 1543 10404; 3518 10404; 5460 1615 8573 11325 ER - TY - JOUR T1 - Opinion: A candidate gene approach to searching for low-penetrance breast and prostate cancer genes AN - 275118034; 16341085 AB - Most cases of breast and prostate cancer are not associated with mutations in known high-penetrance genes, indicating the involvement of multiple low-penetrance risk alleles. Studies that have attempted to identify these genes have met with limited success. The National Cancer Institute Breast and Prostate Cancer Cohort Consortium--a pooled analysis of multiple large cohort studies with a total of more than 5,000 cases of breast cancer and 8,000 cases of prostate cancer--was therefore initiated. The goal of this consortium is to characterize variations in approximately 50 genes that mediate two pathways that are associated with these cancers--the steroid-hormone metabolism pathway and the insulin-like growth factor signalling pathway--and to associate these variations with cancer risk. JF - Nature Reviews. Cancer AU - Hunter, David Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 977 EP - 85 CY - London PB - Nature Publishing Group VL - 5 IS - 12 SN - 1474175X KW - Medical Sciences--Oncology KW - Gonadal Steroid Hormones KW - Prostatic Neoplasms -- metabolism KW - Humans KW - Cohort Studies KW - Gonadal Steroid Hormones -- metabolism KW - Breast Neoplasms -- metabolism KW - Male KW - Female KW - Breast Neoplasms -- genetics KW - Penetrance KW - Genes, Neoplasm KW - Prostatic Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/275118034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews.+Cancer&rft.atitle=Opinion%3A+A+candidate+gene+approach+to+searching+for+low-penetrance+breast+and+prostate+cancer+genes&rft.au=Hunter%2C+David&rft.aulast=Hunter&rft.aufirst=David&rft.date=2005-12-01&rft.volume=5&rft.issue=12&rft.spage=977&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews.+Cancer&rft.issn=1474175X&rft_id=info:doi/10.1038%2Fnrc1754 LA - English DB - ProQuest Central N1 - Copyright - Copyright Nature Publishing Group Dec 2005 N1 - Last updated - 2014-04-30 DO - http://dx.doi.org/10.1038/nrc1754 ER - TY - JOUR T1 - In vivo single-shot, proton-localized 13C MRS of rhesus monkey brain AN - 21067891; 8632097 AB - A single-shot, proton-localized, polarization transfer 13C spectroscopic method was proposed and implemented on a 4.7T scanner for studying rhesus monkey brains. The polarization transfer sequence was mostly adiabatic, minimizing signal loss due to B1 inhomogeneity. RF pulses in polarization transfer were also used for voxel selection of protons with gradient fields. The transferred 13C magnetization was refocused by additional refocusing adiabatic pulses. With the intravenous infusion of D-[1-13C]glucose solution, 13C NMR spectra from a 30mL voxel were acquired for the resonances of C1 of glucose, C2,3,4 of glutamate and glutamine. The time-resolved turnover of glutamate, glutamine and aspartate from intravenously infused D-[1-13C]glucose at a temporal resolution of 12min was demonstrated with excellent spectral resolution and signal-to-noise ratio. Typically, the half-height linewidth of the decoupled 13C peaks was 4Hz. Data obtained with infusion of sodium [2-13C]acetate using the proposed polarization transfer method and data from the carboxylic carbon region using non-localized acquisition are also presented. Published in 2005 by John Wiley & Sons, Ltd. JF - NMR in Biomedicine AU - Li, Shizhe AU - Chen, Zhengguang AU - Zhang, Yan AU - Lizak, Martin AU - Bacher, John AU - Innis, Robert B AU - Shen, Jun AD - National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA, shenj@intra.nimh.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 560 EP - 569 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 18 IS - 8 SN - 0952-3480, 0952-3480 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Glutamine KW - Glucose KW - Carbon KW - N.M.R. KW - Macaca mulatta KW - Intravenous administration KW - Data processing KW - Protons KW - Brain KW - Polarization KW - Sodium KW - Adiabatic KW - Glutamic acid KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21067891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=In+vivo+single-shot%2C+proton-localized+13C+MRS+of+rhesus+monkey+brain&rft.au=Li%2C+Shizhe%3BChen%2C+Zhengguang%3BZhang%2C+Yan%3BLizak%2C+Martin%3BBacher%2C+John%3BInnis%2C+Robert+B%3BShen%2C+Jun&rft.aulast=Li&rft.aufirst=Shizhe&rft.date=2005-12-01&rft.volume=18&rft.issue=8&rft.spage=560&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=09523480&rft_id=info:doi/10.1002%2Fnbm.993 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Macaca mulatta; Polarization; Glutamic acid; Data processing; Brain; N.M.R.; Adiabatic; Glutamine; Carbon; Sodium; Intravenous administration; Glucose; Protons DO - http://dx.doi.org/10.1002/nbm.993 ER - TY - JOUR T1 - A diffusion tensor imaging analysis of gender differences in water diffusivity within human skeletal muscle AN - 21063363; 8632089 AB - The diffusive properties of adjacent muscles at rest were evaluated in male (n=12) and female (n=12) subjects using diffusion tensor imaging (DTI). The principle, second and third eigenvalues, trace of the diffusion tensor [Tr(D)], and two anisotropic parameters, ellipsoid eccentricity (e) and fractional anisotropy (FA), of various muscles in the human calf were calculated from the diffusion tensor. Seven muscles were investigated in this study from images acquired of the left calf: the soleus, lateral gastrocnemius, medial gastrocnemius, posterior tibialis, anterior tibialis, extensor digitorum longus and peroneus longus. A mathematical model was also derived that relates the eigenvalues of the diffusion tensor to the muscle fiber volume fraction, which is defined as the volume of muscle fibers within a well-defined arbitrary muscle volume. Females on average had higher eigenvalues and Tr(D) compared with males, with the majority of muscles being statistically different between the sexes. In contrast, males on average had higher e and FA than females, with the large plantar flexors-soleus, lateral gastrocnemius, and medial gastrocnemius-producing statistically different results. The behavior of the mathematical model for variations in fiber volume fraction produced similar trends to those seen when the experimental data were fit to the model. The model predicts that a larger volume fraction of skeletal muscle in males is devoted to fibers than in females, but the true underlying source of the gender discrepancy remains unclear. Although the model does not fully account for other transport processes, it does provide some insight into the limiting factors that affect the diffusion of water in skeletal muscle measured by DTI. JF - NMR in Biomedicine AU - Galban, Craig J AU - Maderwald, Stefan AU - Uffmann, Kai AU - Ladd, Mark E AD - Department of Diagnostic and Interventional Radiology, University Hospital Essen, Hufelandstrasse 55, D-45122 Essen, Germany, galbanc@ors.od.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 489 EP - 498 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 18 IS - 8 SN - 0952-3480, 0952-3480 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Anisotropy KW - Mathematical models KW - Magnetic resonance imaging KW - Diffusion KW - N.M.R. KW - Skeletal muscle KW - Limiting factors KW - Sex differences KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21063363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=A+diffusion+tensor+imaging+analysis+of+gender+differences+in+water+diffusivity+within+human+skeletal+muscle&rft.au=Galban%2C+Craig+J%3BMaderwald%2C+Stefan%3BUffmann%2C+Kai%3BLadd%2C+Mark+E&rft.aulast=Galban&rft.aufirst=Craig&rft.date=2005-12-01&rft.volume=18&rft.issue=8&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=09523480&rft_id=info:doi/10.1002%2Fnbm.975 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Skeletal muscle; Mathematical models; Anisotropy; Magnetic resonance imaging; Sex differences; Data processing; N.M.R.; Diffusion; Limiting factors DO - http://dx.doi.org/10.1002/nbm.975 ER - TY - JOUR T1 - CpG-containing oligodeoxynucleotide promotes microglial cell uptake of amyloid ss 1-42 peptide by up-regulating the expression of the G-protein-coupled receptor mFPR2 AN - 21053094; 7327148 AB - Inflammation contributes to the pathogenic process of Alzheimer's disease (AD). We previously discovered that a human G-protein-coupled formyl peptide receptor-like 1 (FPRL1) and its mouse homologue mFPR2 mediate the chemotaxis and activation of mononuclear phagocytes in response to a variety of peptide agonists, including amyloid ss 1-42 (Ass sub(42)), which is neurotoxic and a key mediator of inflammatory responses in AD. Since mFPR2 is up-regulated in mouse microglia by lipopolysaccharide (LPS), a Toll-like receptor 4 ligand, the aim of this study is to investigate whether TLR9, which is activated by CpG-containing oligodeoxynucleotide (ODN) as well as by potential agonists released by damaged host cells, may also enhance the expression and function of mFPR2, thereby affecting the progress of AD. JF - FASEB Journal AU - Iribarren, P AU - Chen, K AU - Hu, J AU - Gong, W AU - Cho, E H AU - Lockett, S AU - Uranchimeg, B AU - Wang, J M AD - Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Bldg. 560, Room 31-40, Frederick, MD 21702-1201, USA, wangji@mail.ncifcrf.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 2032 EP - 2034 VL - 19 IS - 14 SN - 0892-6638, 0892-6638 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Alzheimer's disease KW - Chemotaxis KW - Oligonucleotides KW - ^b-Amyloid KW - G protein-coupled receptors KW - Phagocytes KW - Lipopolysaccharides KW - Microglial cells KW - TLR4 protein KW - TLR9 protein KW - Microglia KW - Inflammation KW - Neurodegenerative diseases KW - Neurotoxicity KW - formyl peptide receptor-like 1 KW - ^AG protein-coupled receptors KW - Toll-like receptors KW - b-Amyloid KW - N3 11028:Neuropharmacology & toxicology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21053094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+Journal&rft.atitle=CpG-containing+oligodeoxynucleotide+promotes+microglial+cell+uptake+of+amyloid+ss+1-42+peptide+by+up-regulating+the+expression+of+the+G-protein-coupled+receptor+mFPR2&rft.au=Iribarren%2C+P%3BChen%2C+K%3BHu%2C+J%3BGong%2C+W%3BCho%2C+E+H%3BLockett%2C+S%3BUranchimeg%2C+B%3BWang%2C+J+M&rft.aulast=Iribarren&rft.aufirst=P&rft.date=2005-12-01&rft.volume=19&rft.issue=14&rft.spage=2032&rft.isbn=&rft.btitle=&rft.title=FASEB+Journal&rft.issn=08926638&rft_id=info:doi/10.1096%2Ffj.05-4578fje LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Alzheimer's disease; Neurodegenerative diseases; Oligonucleotides; Lipopolysaccharides; Inflammation; Toll-like receptors; b-Amyloid; Phagocytes; Microglia; formyl peptide receptor-like 1; TLR9 protein; TLR4 protein; Microglial cells; Chemotaxis; G protein-coupled receptors; Neurotoxicity; ^b-Amyloid; ^AG protein-coupled receptors DO - http://dx.doi.org/10.1096/fj.05-4578fje ER - TY - JOUR T1 - Conjugates of Group A and W135 Capsular Polysaccharides of Neisseria meningitidis Bound to Recombinant Staphylococcus aureus Enterotoxin C1: Preparation, Physicochemical Characterization, and Immunological Properties in Mice AN - 20986440; 7142798 AB - Neisseria meningitidis groups A (GAM) and W135 capsular polysaccharides (CPs) were bound to recombinant Staphylococcus aureus enterotoxin C1 (rSEC). The CPs were activated with 1-cyano-4-dimethylaminopyridinium tetrafluoroborate and then bound to adipic acid dihydrazide derivatives of rSEC. Syntheses were conducted with native GAM CP (GAMP), W135 CP (W135P), and ultrasonicated or hydrazine-treated W135P at various concentrations of reactants, pHs, and ionic strengths. The conjugates were characterized by compositional and serologic analyses, high-performance size-exclusion chromatography with multi-angle laser light scattering detection, and immunogenicity in 5- to 6-week-old mice. Conjugates injected subcutaneously in phosphate-buffered saline elicited immunoglobulin G (IgG) responses against their respective CPs and rSEC, whereas GAMP and W135P alone did not induce detectable CP antibodies. The O-acetyl content of W135P was low, and its removal had no adverse effect upon the conjugate's immunogenicity. Reduction of the molecular size of W135P by treatment with hydrazine improved the immunogenicity of W135P-rSEC. IgG anti-CP elicited by the conjugates showed complement-dependent bactericidal activity against their respective organisms, and IgG anti-rSEC neutralized the T-cell proliferative activity of native SEC. A bivalent formulation of GAMP-rSEC and W135P-rSEC elicited IgG anti-CP at comparable levels to those induced by the conjugates administered separately. JF - Infection and Immunity AU - Jin, Zhigang AU - Bohach, Gregory A AU - Shiloach, Joseph AU - Norris, Scott E AU - Freedberg, Daron I AU - Deobald, Claudia AU - Coxon, Bruce AU - Robbins, John B AU - Schneerson, Rachel AD - National Institute of Child Health and Human Development. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892. Department of Microbiology, Molecular Biology and Biochemistry, University of Idaho, Moscow, Idaho 83844. Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892 Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 7887 EP - 7893 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 73 IS - 12 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Ionic strength KW - Hydrazine KW - Chromatography KW - Light scattering KW - Neisseria meningitidis KW - Adipic acid dihydrazide KW - Polysaccharides KW - Immunogenicity KW - Lymphocytes T KW - Immunoglobulin G KW - Lasers KW - Enterotoxins KW - Staphylococcus aureus KW - Bactericidal activity KW - Capsular polysaccharides KW - Side effects KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20986440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Conjugates+of+Group+A+and+W135+Capsular+Polysaccharides+of+Neisseria+meningitidis+Bound+to+Recombinant+Staphylococcus+aureus+Enterotoxin+C1%3A+Preparation%2C+Physicochemical+Characterization%2C+and+Immunological+Properties+in+Mice&rft.au=Jin%2C+Zhigang%3BBohach%2C+Gregory+A%3BShiloach%2C+Joseph%3BNorris%2C+Scott+E%3BFreedberg%2C+Daron+I%3BDeobald%2C+Claudia%3BCoxon%2C+Bruce%3BRobbins%2C+John+B%3BSchneerson%2C+Rachel&rft.aulast=Jin&rft.aufirst=Zhigang&rft.date=2005-12-01&rft.volume=73&rft.issue=12&rft.spage=7887&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Hydrazine; Ionic strength; Chromatography; Light scattering; Polysaccharides; Adipic acid dihydrazide; Immunogenicity; Immunoglobulin G; Lymphocytes T; Enterotoxins; Lasers; Capsular polysaccharides; Bactericidal activity; Side effects; Neisseria meningitidis; Staphylococcus aureus ER - TY - JOUR T1 - PfCG2, a Plasmodium falciparum protein peripherally associated with the parasitophorous vacuolar membrane, is expressed in the period of maximum hemoglobin uptake and digestion by trophozoites AN - 20957324; 8338134 AB - A Plasmodium falciparum gene closely linked to the chloroquine resistance locus encodes PfCG2, a predicted 320-330 kDa protein. In the parasitized erythrocyte, PfCG2 expression rises sharply in the trophozoite stage and is detected in electron-dense patches along the parasitophorous vacuolar membrane (PVM), in the cytoplasm and in the digestive vacuole (DV). Results of extraction and partitioning experiments show that PfCG2 is a peripheral membrane protein. Exposure of trophozoite-infected erythrocytes to trypsin-containing buffer after streptolysin O permeabilization indicates that PfCG2 is exposed to the erythrocyte cytosol at the outer face of the PVM. PfCG2 is highly susceptible to hydrolysis by aspartic and cysteine proteases and shows dose-dependent accumulation in the presence of protease inhibitors. These results suggest that PfCG2 is delivered from the outside face of the PVM to the DV, where it is broken down by parasite proteases. PfCG2 interacts with erythrocyte cytoplasm and may be associated with processes of hemoglobin uptake and digestion by erythrocytic-stage parasites. JF - Molecular and Biochemical Parasitology AU - Cooper, Roland A AU - Papakrivos, Janni AU - Lane, Kristin D AU - Fujioka, Hisashi AU - Lingelbach, Klaus AU - Wellems, Thomas E AD - Laboratory of Malaria and Vector Research, Twinbrook III, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8132, USA, twellems@niaid.nih.gov Y1 - 2005/12// PY - 2005 DA - December 2005 SP - 167 EP - 176 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl] VL - 144 IS - 2 SN - 0166-6851, 0166-6851 KW - Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Malaria KW - Endocytosis KW - Phagocytosis KW - Protein trafficking KW - Proteases KW - Parasites KW - Proteinase inhibitors KW - Erythrocytes KW - Chloroquine KW - Plasmodium falciparum KW - Membrane proteins KW - Hydrolysis KW - Hemoglobin KW - Digestion KW - Bioaccumulation KW - Cysteine KW - Cytoplasm KW - Vacuoles KW - Cytosol KW - Proteins KW - Haemoglobins KW - Trophozoites KW - Cysteine proteinase KW - G 07880:Human Genetics KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08501:General KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20957324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Biochemical+Parasitology&rft.atitle=PfCG2%2C+a+Plasmodium+falciparum+protein+peripherally+associated+with+the+parasitophorous+vacuolar+membrane%2C+is+expressed+in+the+period+of+maximum+hemoglobin+uptake+and+digestion+by+trophozoites&rft.au=Cooper%2C+Roland+A%3BPapakrivos%2C+Janni%3BLane%2C+Kristin+D%3BFujioka%2C+Hisashi%3BLingelbach%2C+Klaus%3BWellems%2C+Thomas+E&rft.aulast=Cooper&rft.aufirst=Roland&rft.date=2005-12-01&rft.volume=144&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Biochemical+Parasitology&rft.issn=01666851&rft_id=info:doi/10.1016%2Fj.molbiopara.2005.07.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Digestion; Parasites; Bioaccumulation; Cysteine; Cytoplasm; Erythrocytes; Proteins; Hydrolysis; Haemoglobins; Hemoglobin; Vacuoles; Proteinase inhibitors; Cytosol; Chloroquine; Membrane proteins; Cysteine proteinase; Trophozoites; Plasmodium falciparum DO - http://dx.doi.org/10.1016/j.molbiopara.2005.07.009 ER - TY - JOUR T1 - Dependence on diffusion time of apparent diffusion tensor of ex vivo calf tongue and heart AN - 20859707; 8367966 AB - The time dependence of the apparent diffusion tensor of ex vivo calf heart and tongue was measured for diffusion times (d) between 32 and 810 ms. The results showed evidence of restricted diffusion in the muscle tissues of both organs. In regions where the myofibers are parallel, the largest eigenvalue (1) of the diffusion tensor remained the same for all diffusion times measured, while the other eigenvalues (2, 3) decreased by 29-36% between d = 32 ms and d = 400 ms. In regions where the fibers cross, the 1 also changed, decreasing by 17% between d = 32 ms and d = 400 ms. The restricting compartment size and volume fraction were effectively estimated by fitting the time courses of the eigenvalues to a model consisting of a nonrestricted compartment and a cylindrically restricted compartment. To our knowledge, this study is the first demonstrating diffusion time dependence of measured water diffusion tensor in muscular tissue. With improvement in scanning technology, future studies may permit noninvasive, in vivo detection of changes in muscle myoarchitecture due to disease, treatment, and exercise. JF - Magnetic Resonance in Medicine AU - Kim, Sungheon AU - Chi-Fishman, Gloria AU - Barnett, Alan S AU - Pierpaoli, Carlo AD - Physical Disabilities Branch, Department of Rehabilitation Medicine, Clinical Research Center, National Institutes of Health, Bethesda, Maryland, USA, sungheonk@cc.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1387 EP - 1396 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 54 IS - 6 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Scanning KW - Muscles KW - N.M.R. KW - Tongue KW - Diffusion KW - Models KW - Physical training KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20859707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Dependence+on+diffusion+time+of+apparent+diffusion+tensor+of+ex+vivo+calf+tongue+and+heart&rft.au=Kim%2C+Sungheon%3BChi-Fishman%2C+Gloria%3BBarnett%2C+Alan+S%3BPierpaoli%2C+Carlo&rft.aulast=Kim&rft.aufirst=Sungheon&rft.date=2005-12-01&rft.volume=54&rft.issue=6&rft.spage=1387&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20676 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Diffusion; Heart; Muscles; Tongue; N.M.R.; Scanning; Physical training; Models DO - http://dx.doi.org/10.1002/mrm.20676 ER - TY - JOUR T1 - Single heartbeat cardiac tagging for the evaluation of transient phenomena AN - 20859474; 8367974 AB - Many cardiac abnormalities are of a transient nature, creating a beat-to-beat variation in myocardial function. This work presents the cardiac imaging technique for the measurement of regional function during transient cardiac phenomena. All information necessary for the reconstruction of a cine loop is acquired within a single heartbeat, avoiding the temporal blurring introduced by segmented imaging due to the assumption of cardiac cycle periodicity. This method incorporates a gradient-optimized, high-efficiency EPI-SSFP sequence and TSENSE parallel imaging. For acquisitions with readout resolutions of 128,160, 192, and 256 points, the technique produced images with average temporal resolution of 35, 39, 43, and 52 ms and average spatial resolutions of 2.65, 2.12, 1.77, and 1.32 mm in the readout direction, respectively, and 2.88 and 2.08 mm in the phase encode direction for acceleration rates of 3 and 4, respectively. Local apparent strains in the single slice and measurements of ventricular end-systolic and end-diastolic areas were used as quantitative measures to validate the single heartbeat technique. To demonstrate the utility of the sequence, movie loops were acquired for multiple heartbeats in non-breath-held acquisitions as well as during a Valsalva maneuver. A heartbeat-interleaved acquisition allowed for the reconstruction of nonaccelerated images from R contiguous heartbeats. Images reconstructed from such data displayed tag blurring and reduced tag persistence due to motion and interheartbeat variability. Images acquired during the Valsalva maneuver demonstrated apparent beat-to-beat variability, visible both in the images and as changing strain patterns and ventricular volumes. JF - Magnetic Resonance in Medicine AU - Herzka, Daniel A AU - Derbyshire, J Andrew AU - Kellman, Peter AU - McVeigh, Elliot R AD - Department of Biomedical Engineering, Johns Hopkins University School of Medicine Baltimore, Maryland, USA, herzkad@nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1455 EP - 1464 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 54 IS - 6 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Data processing KW - Image processing KW - Periodicity KW - spatial discrimination KW - N.M.R. KW - imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20859474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Single+heartbeat+cardiac+tagging+for+the+evaluation+of+transient+phenomena&rft.au=Herzka%2C+Daniel+A%3BDerbyshire%2C+J+Andrew%3BKellman%2C+Peter%3BMcVeigh%2C+Elliot+R&rft.aulast=Herzka&rft.aufirst=Daniel&rft.date=2005-12-01&rft.volume=54&rft.issue=6&rft.spage=1455&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20719 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Heart; imaging; N.M.R.; Data processing; Image processing; spatial discrimination; Periodicity DO - http://dx.doi.org/10.1002/mrm.20719 ER - TY - JOUR T1 - Image reconstruction in SNR units: A general method for SNR measurement AN - 20859112; 8367972 AB - The method for phased array image reconstruction of uniform noise images may be used in conjunction with proper image scaling as a means of reconstructing images directly in SNR units. This facilitates accurate and precise SNR measurement on a per pixel basis. This method is applicable to root-sum-of-squares magnitude combining, B1-weighted combining, and parallel imaging such as SENSE. A procedure for image reconstruction and scaling is presented, and the method for SNR measurement is validated with phantom data. Alternative methods that rely on noise only regions are not appropriate for parallel imaging where the noise level is highly variable across the field-of-view. The purpose of this article is to provide a nuts and bolts procedure for calculating scale factors used for reconstructing images directly in SNR units. The procedure includes scaling for noise equivalent bandwidth of digital receivers, FFTs and associated window functions (raw data filters), and array combining. JF - Magnetic Resonance in Medicine AU - Kellman, Peter AU - McVeigh, Elliot R AD - Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland 20892-1061, USA, kellman@nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1439 EP - 1447 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 54 IS - 6 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Filters KW - Data processing KW - Nuts KW - Image processing KW - N.M.R. KW - imaging KW - Scaling KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20859112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Image+reconstruction+in+SNR+units%3A+A+general+method+for+SNR+measurement&rft.au=Kellman%2C+Peter%3BMcVeigh%2C+Elliot+R&rft.aulast=Kellman&rft.aufirst=Peter&rft.date=2005-12-01&rft.volume=54&rft.issue=6&rft.spage=1439&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20713 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Scaling; Image processing; Data processing; imaging; N.M.R.; Filters; Nuts DO - http://dx.doi.org/10.1002/mrm.20713 ER - TY - JOUR T1 - Absolute oxygen tension (pO2) in murine fatty and muscle tissue as determined by EPR AN - 20856783; 8367981 AB - The absolute partial pressure of oxygen (pO2) in the mammary gland pad and femoral muscle of female mice was measured using EPR oximetry at 700 MHz. A small quantity of lithium phthalocyanine (LiPc) crystals was implanted in both mammary and femoral muscle tissue of female C3H mice. Subsequent EPR measurements were carried out 1-30 days after implantation with or without control of core body temperature. The pO2 values in the tissue became stable 2 weeks after implantation of LiPc crystals. The pO2 level was found to be higher in the femoral muscle than in the mammary tissue. However, the pO2 values showed a strong dependence on the core body temperature of the mice. The pO2 values were responsive to carbogen (95% O2, 5% CO2) breathing even 44-58 days after the implantation of LiPc. The LiPc linewidth was also sensitive to changes in the blood supply even 60 days after implantation of the crystals. This study further validates the use of LiPc crystals and EPR oximetry for long-term non-invasive assessment of pO2 levels in tissues, underscores the importance of maintaining normal body core temperature during the measurements, and demonstrates that mammary tissue functions at a lower pO2 level than muscle in female C3H mice. JF - Magnetic Resonance in Medicine AU - Matsumoto, Atsuko AU - Matsumoto, Shingo AU - Sowers, Anastasia L AU - Koscielniak, Janusz W AU - Trigg, Nancy J AU - Kuppusamy, Periannan AU - Mitchell, James B AU - Subramanian, Sankaran AU - Krishna, Murali C AU - Matsumoto, Ken-ichiro AD - Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA, murali@helix.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1530 EP - 1535 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 54 IS - 6 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Oxygen tension KW - Body temperature KW - Mammary gland KW - Respiration KW - Muscles KW - Crystals KW - Femur KW - Blood KW - N.M.R. KW - Pressure KW - Carbon dioxide KW - Lithium KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20856783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Absolute+oxygen+tension+%28pO2%29+in+murine+fatty+and+muscle+tissue+as+determined+by+EPR&rft.au=Matsumoto%2C+Atsuko%3BMatsumoto%2C+Shingo%3BSowers%2C+Anastasia+L%3BKoscielniak%2C+Janusz+W%3BTrigg%2C+Nancy+J%3BKuppusamy%2C+Periannan%3BMitchell%2C+James+B%3BSubramanian%2C+Sankaran%3BKrishna%2C+Murali+C%3BMatsumoto%2C+Ken-ichiro&rft.aulast=Matsumoto&rft.aufirst=Atsuko&rft.date=2005-12-01&rft.volume=54&rft.issue=6&rft.spage=1530&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20714 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Muscles; Crystals; Femur; Body temperature; Carbon dioxide; Blood; Oxygen tension; N.M.R.; Respiration; Mammary gland; Lithium; Pressure DO - http://dx.doi.org/10.1002/mrm.20714 ER - TY - JOUR T1 - Real-time blood flow imaging using autocalibrated spiral sensitivity encoding AN - 20854987; 8367986 AB - A novel spiral phase contrast (PC) technique was developed for high temporal resolution imaging of blood flow without cardiac gating. An autocalibrated spiral sensitivity encoding (SENSE) method is introduced and used to reconstruct PC images. Numerical simulations and a flow phantom study were performed to validate the technique. To study the accuracy of the flow measurement in vivo, a high-resolution cardiac experiment was performed and a subset of undersampled SENSE reconstructed data were reconstructed. Good agreement between the velocity measurement from the fully-sampled and undersampled data was achieved. Real-time experiments were performed to measure blood velocity in the ascending aorta and aortic valve, and during a Valsalva maneuver. The results demonstrate the potential of this technique for real-time flow imaging. JF - Magnetic Resonance in Medicine AU - Nezafat, Reza AU - Kellman, Peter AU - Derbyshire, J Andrew AU - McVeigh, Elliot R AD - Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA, nezafatr@nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1557 EP - 1561 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 54 IS - 6 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Data processing KW - Aortic valve KW - Aorta KW - Gating KW - N.M.R. KW - imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20854987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Real-time+blood+flow+imaging+using+autocalibrated+spiral+sensitivity+encoding&rft.au=Nezafat%2C+Reza%3BKellman%2C+Peter%3BDerbyshire%2C+J+Andrew%3BMcVeigh%2C+Elliot+R&rft.aulast=Nezafat&rft.aufirst=Reza&rft.date=2005-12-01&rft.volume=54&rft.issue=6&rft.spage=1557&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20690 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - imaging; Data processing; Heart; N.M.R.; Gating; Aortic valve; Aorta DO - http://dx.doi.org/10.1002/mrm.20690 ER - TY - JOUR T1 - In vivo carbon-13 magnetization transfer effect. Detection of aspartate aminotransferase reaction AN - 20852952; 8367958 AB - One of the most remarkable achievements of in vivo NMR spectroscopy has been the detection of rapid enzyme-catalyzed exchange reactions using phosphorus-31 magnetic resonance spectroscopy-based magnetization transfer experiments. In this paper, we report, for the first time, the in vivo carbon magnetization transfer (CMT) effect and in vivo detection of the CMT effects of the -ketoglutarate glutamate and the oxaloacetate aspartate reactions, both of which are catalyzed by aspartate aminotransferase. By saturating the carbonyl carbon of -ketoglutarate at 206 ppm in -chloralose anesthetized adult rat brain, the unidirectional glutamate -ketoglutarate flux was determined to be 78 - 9 mol/g/min (mean - SD, n = 11) following i.v. infusion of [1,6-13C2]D-glucose. Contribution from aspartate aminotransferase-catalyzed partial reactions to the observed CMT effects was emphasized. Because of the large chemical shift separation between the -carbons of the amino acids and the carbonyl carbons of the corresponding cognate keto acids, the spillover of the saturation radiofrequency pulses to the -carbon resonances was negligible. The results indicate that the magnetization transfer effects of aspartate aminotransferase-catalyzed reactions can be used as new biomarkers accessible to non-invasive in vivo magnetic resonance spectroscopy techniques. JF - Magnetic Resonance in Medicine AU - Shen, Jun AD - Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland, USA, shenj@intra.nimh.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1321 EP - 1326 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 54 IS - 6 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Amino acids KW - Carbon KW - Aspartate aminotransferase KW - Acids KW - Magnetic resonance spectroscopy KW - Brain KW - N.M.R. KW - Glutamic acid KW - biomarkers KW - carbonyls KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20852952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=In+vivo+carbon-13+magnetization+transfer+effect.+Detection+of+aspartate+aminotransferase+reaction&rft.au=Shen%2C+Jun&rft.aulast=Shen&rft.aufirst=Jun&rft.date=2005-12-01&rft.volume=54&rft.issue=6&rft.spage=1321&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20709 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Carbon; Magnetic resonance spectroscopy; Glutamic acid; N.M.R.; carbonyls; Aspartate aminotransferase; Amino acids; biomarkers; Brain; Acids DO - http://dx.doi.org/10.1002/mrm.20709 ER - TY - JOUR T1 - Immune-Related Conditions and Immune-Modulating Medications as Risk Factors for Non-Hodgkin's Lymphoma: A Case-Control Study AN - 20715076; 6576056 AB - In immunosuppressed or autoimmune disease states, disordered immune responses may lead to non-Hodgkin's lymphoma (NHL). In a US population-based case-control study of NHL (1998-2000), the authors collected personal histories of immune-related conditions and use of immune-modulating therapies as well as family histories of autoimmune conditions. The study included 1,321 NHL cases and 1,057 controls; only half received some questionnaire components. NHL was associated with Sjoegren's syndrome (odds ratio (OR) = 13, 95% confidence interval (CI): 1.7, 100) and lupus (OR = 4.2, 95% CI: 1.2, 15). Two specific NHL subtypes were strongly associated with Sjoegren's syndrome: salivary gland (OR = 290, 95% CI: 33, 2600) and marginal zone (OR = 75, 95% CI: 9.1, 610). NHL was less convincingly associated with receipt of an organ transplant (OR = 2.0, 95% CI: 0.4, 11). Other autoimmune conditions were too rare to evaluate or not associated with NHL. Corticosteroid use was unrelated to NHL (OR = 1.0, 95% CI: 0.8, 1.2), but methotrexate use was marginally associated (OR = 2.3, 95% CI: 0.7, 7.5). Family history of dermatomyositis was associated with NHL (7 cases vs. 0 controls, OR = infinite; two-sided p = 0.02), but dermatomyositis was absent in cases themselves. Family history of remaining conditions was unrelated to NHL. Results suggest that disordered immunity in some immune-related conditions can lead to NHL. JF - American Journal of Epidemiology AU - Engels, Eric A AU - Cerhan, James R AU - Linet, Martha S AU - Cozen, Wendy AU - Colt, Joanne S AU - Davis, Scott AU - Gridley, Gloria AU - Severson, Richard K AU - Hartge, Patricia AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1153 EP - 1161 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 162 IS - 12 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; Immunology Abstracts KW - non-Hodgkin's lymphoma KW - Historical account KW - Inventories KW - Autoimmune diseases KW - autoimmune diseases KW - Immunity KW - Salivary gland KW - Organs KW - Immunomodulation KW - Sjogren's syndrome KW - Genetics KW - Non-Hodgkin's lymphoma KW - Corticoids KW - Dermatomyositis KW - Risk factors KW - Methotrexate KW - Drugs KW - corticoids KW - R2 23060:Medical and environmental health KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20715076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Immune-Related+Conditions+and+Immune-Modulating+Medications+as+Risk+Factors+for+Non-Hodgkin%27s+Lymphoma%3A+A+Case-Control+Study&rft.au=Engels%2C+Eric+A%3BCerhan%2C+James+R%3BLinet%2C+Martha+S%3BCozen%2C+Wendy%3BColt%2C+Joanne+S%3BDavis%2C+Scott%3BGridley%2C+Gloria%3BSeverson%2C+Richard+K%3BHartge%2C+Patricia&rft.aulast=Engels&rft.aufirst=Eric&rft.date=2005-12-01&rft.volume=162&rft.issue=12&rft.spage=1153&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Sjogren's syndrome; Corticoids; Inventories; Non-Hodgkin's lymphoma; Dermatomyositis; Risk factors; Autoimmune diseases; Methotrexate; Immunity; Salivary gland; Immunomodulation; non-Hodgkin's lymphoma; Historical account; Genetics; autoimmune diseases; Drugs; Organs; corticoids ER - TY - JOUR T1 - Countermeasures to the Bioterrorist Threat of Smallpox AN - 20305551; 7653965 AB - Variola, the agent of smallpox, is a bioterrorist threat, as is monkeypox virus, which also occurs naturally in Africa. Development of countermeasures, in the form of improved vaccines, antiviral drugs, and other therapeutic strategies are a high priority. Recent advances in molecular biology and in animal model development have provided fresh insight into the virulence determinants for smallpox and the pathophysiology of disease. The complex replication cycle for orthopoxviruses, and the pivotal role for viralspecific immunomodulatory proteins which contribute to escape from immunologic surveillance, provide many unique targets for therapeutic intervention. The "toxemia" of smallpox has been elucidated in part by variola- infected primate studies which revealed the central role of apoptosis and the evolution of a cytokine storm leading to hemorrhagic diathesis, resembling fulminent "black" smallpox. This suggests a potential role for therapeutic strategies developed for septic shock, in treatment of smallpox. Drugs licensed for other viruses which share molecular targets with orthopoxviruses (e.g. Cidofovir) or cancer drugs (e.g. Gleevec and other tyrosine kinase inhibitors) have immediate application for treatment of smallpox and monkeypox and provide leads for second generation drugs with higher therapeutic indices. Recent advances in identification of virulence determinants and immune evasion genes facilitate the design of alternative vaccines to replace live vaccinia strains that are unsuitable for a large proportion of individuals in a mass immunization campaign. JF - Current Molecular Medicine AU - Jahrling, Peter B AU - Fritz, Elizabeth A AU - Hensley, Lisa E AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6700-B Rockledge Drive, Bethesda, MD 20892-7609, USA. Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 817 EP - 826 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 5 IS - 8 SN - 1566-5240, 1566-5240 KW - Primates KW - Virology & AIDS Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Therapeutic applications KW - Hemorrhage KW - Virulence KW - Protein-tyrosine kinase KW - Variola KW - Monkeypox virus KW - Replication KW - Vaccinia KW - Drug development KW - Septic shock KW - Immunization KW - Vaccines KW - Apoptosis KW - Animal models KW - Immunosuppressive agents KW - Antiviral agents KW - Cytokines KW - Cidofovir KW - Monkeypox KW - Toxemia KW - Cancer KW - Smallpox KW - Evolution KW - F 06905:Vaccines KW - V 22350:Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20305551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Molecular+Medicine&rft.atitle=Countermeasures+to+the+Bioterrorist+Threat+of+Smallpox&rft.au=Jahrling%2C+Peter+B%3BFritz%2C+Elizabeth+A%3BHensley%2C+Lisa+E&rft.aulast=Jahrling&rft.aufirst=Peter&rft.date=2005-12-01&rft.volume=5&rft.issue=8&rft.spage=817&rft.isbn=&rft.btitle=&rft.title=Current+Molecular+Medicine&rft.issn=15665240&rft_id=info:doi/10.2174%2F156652405774962326 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Monkeypox virus; Variola; Primates; Smallpox; Antiviral agents; Immunosuppressive agents; Vaccines; Virulence; Monkeypox; Protein-tyrosine kinase; Vaccinia; Hemorrhage; Cytokines; Apoptosis; Cancer; Replication; Therapeutic applications; Animal models; Evolution; Drug development; Toxemia; Immunization; Septic shock; Cidofovir DO - http://dx.doi.org/10.2174/156652405774962326 ER - TY - JOUR T1 - Perfusion-based fMRI: Insights from animal models AN - 20243437; 7456810 AB - Modern functional neuroimaging techniques, including functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and optical imaging of intrinsic signals (OIS), rely on a tight coupling between neural activity and cerebral blood flow (CBF) to visualize brain activity using CBF as a surrogate marker. Because CBF is a uniquely defined physiological parameter, fMRI techniques based on CBF contrast have the advantage of being specific to tissue signal change, and the potential to provide more direct and quantitative measures of brain activation than blood oxygenation level-dependent (BOLD)- or cerebral blood volume (CBV)-based techniques. The changes in CBF elicited by increased neural activity are an excellent index of the magnitude of electrical activity. Increases in CBF are more closely localized to the foci of increased electrical activity, and occur more promptly to the stimulus than BOLD- or CBV- based contrast. In addition, CBF-based fMRI is less affected by confounds from venous drainage common to BOLD. Animal studies of brain activation have yielded considerable insights into the advantages of CBF-based fMRI. Based on results provided by animal studies, CBF fMRI may offer a means of better assessing the magnitude, spatial extent, and temporal response of neural activity, and may be more specific to tissue state. These properties are expected to be particularly useful for longitudinal and quantitative fMRI studies. J. Magn. Reson. Imaging 2005. Published 2005 Wiley-Liss, Inc. JF - Journal of Magnetic Resonance Imaging AU - Silva, Afonso C AD - Cerebral Microcirculation Unit, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA, silvaa@ninds.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 745 EP - 750 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 22 IS - 6 SN - 1053-1807, 1053-1807 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - functional magnetic resonance imaging KW - arterial spin labeling KW - animal models KW - cerebral blood flow KW - spatial resolution KW - temporal resolution KW - Brain mapping KW - Neuroimaging KW - Functional magnetic resonance imaging KW - Positron emission tomography KW - Animal models KW - Cerebral blood flow KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20243437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Magnetic+Resonance+Imaging&rft.atitle=Perfusion-based+fMRI%3A+Insights+from+animal+models&rft.au=Silva%2C+Afonso+C&rft.aulast=Silva&rft.aufirst=Afonso&rft.date=2005-12-01&rft.volume=22&rft.issue=6&rft.spage=745&rft.isbn=&rft.btitle=&rft.title=Journal+of+Magnetic+Resonance+Imaging&rft.issn=10531807&rft_id=info:doi/10.1002%2Fjmri.20461 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Brain mapping; Neuroimaging; Functional magnetic resonance imaging; Animal models; Positron emission tomography; Cerebral blood flow DO - http://dx.doi.org/10.1002/jmri.20461 ER - TY - JOUR T1 - Technological advances in MRI measurement of brain perfusion AN - 20242018; 7456807 AB - Measurement of brain perfusion using arterial spin labeling (ASL) or dynamic susceptibility contrast (DSC) based MRI has many potential important clinical applications. However, the clinical application of perfusion MRI has been limited by a number of factors, including a relatively poor spatial resolution, limited volume coverage, and low signal-to-noise ratio (SNR). It is difficult to improve any of these aspects because both ASL and DSC methods require rapid image acquisition. In this report, recent methodological developments are discussed that alleviate some of these limitations and make perfusion MRI more suitable for clinical application. In particular, the availability of high magnetic field strength systems, increased gradient performance, the use of RF coil arrays and parallel imaging, and increasing pulse sequence efficiency allow for increased image acquisition speed and improved SNR. The use of parallel imaging facilitates the trade-off of SNR for increases in spatial resolution. As a demonstration, we obtained DSC and ASL perfusion images at 3.0 T and 7.0 T with multichannel RF coils and parallel imaging, which allowed us to obtain high-quality images with in-plane voxel sizes of 1.5 X 1.5 mm super(2). J. Magn. Reson. Imaging 2005. Published 2005 Wiley-Liss, Inc. JF - Journal of Magnetic Resonance Imaging AU - Duyn, Jeff H AU - Van Gelderen, Peter AU - Talagala, Lalith AU - Koretsky, Alan AU - De Zwart, Jacco A AD - Advanced MRI Laboratory, National Institutes of Health, Bethesda, Maryland, USA, jhd@helix.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 751 EP - 753 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 22 IS - 6 SN - 1053-1807, 1053-1807 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - MR imaging KW - perfusion KW - resolution KW - coil arrays KW - parallel imaging KW - Magnetic fields KW - Neuroimaging KW - Perfusion KW - Magnetic resonance imaging KW - Brain KW - spatial discrimination KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20242018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Magnetic+Resonance+Imaging&rft.atitle=Technological+advances+in+MRI+measurement+of+brain+perfusion&rft.au=Duyn%2C+Jeff+H%3BVan+Gelderen%2C+Peter%3BTalagala%2C+Lalith%3BKoretsky%2C+Alan%3BDe+Zwart%2C+Jacco+A&rft.aulast=Duyn&rft.aufirst=Jeff&rft.date=2005-12-01&rft.volume=22&rft.issue=6&rft.spage=751&rft.isbn=&rft.btitle=&rft.title=Journal+of+Magnetic+Resonance+Imaging&rft.issn=10531807&rft_id=info:doi/10.1002%2Fjmri.20450 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Magnetic fields; Neuroimaging; Perfusion; Magnetic resonance imaging; Brain; spatial discrimination DO - http://dx.doi.org/10.1002/jmri.20450 ER - TY - JOUR T1 - Nano-sized MRI contrast agents with dendrimer cores AN - 20219549; 7199800 AB - Gadolinium-based MRI contrast agents (CAs) can be effective at a 100-fold lower concentration of Gadolinium ions in comparison to the concentration of Iodine atoms required for CT imaging. Therefore, a number of dendrimer based macromolecular MRI CAs of various sizes and properties prepared employing relatively simple chemistry are readily available that can provide sufficient contrast enhancement for various applications. Molecules up to 20 nm in diameter behave differently in the body depending on their size. Even if these molecules possess similar chemical properties, small changes in size can greatly impact their pharmacokinetics. Changes in molecular size up to 15 nm in diameter altered permeability across the vascular wall, excretion route, and recognition by the reticuloendothelial system. Smaller sized polyamidoamine (PAMAM) dendrimer-based contrast agents, i.e., less than 3 nm in diameter, easily "leak" across the vascular wall resulting in rapid perfusion throughout the body. Contrast agents 3-6 nm in diameter were quickly excreted through the kidney indicating these agents to be potentially suitable as functional renal contrast agents. Contrast agents 7-12 nm in diameter were retained in circulation and were better suited for use as blood pool contrast agents. Hydrophobic variants of CAs formed with polypropylenimine diaminobutane (DAB) dendrimer cores quickly accumulated in the liver and potentially have use as liver contrast agents. Larger hydrophilic agents have suitable characteristics for lymphatic imaging. Finally, contrast agents conjugated with either monoclonal antibodies or with avidin are able to function as tumor-specific contrast agents and might also be employed as either gadolinium neutron capture therapy or in conjunction with radioimmunotherapy. JF - Advanced Drug Delivery Reviews AU - Kobayashi, Hisataka AU - Brechbiel, Martin W AD - Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Room 1B40, 10 Center Drive, Bethesda, MD 20892-1088, USA, Kobayash@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 2271 EP - 2286 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 57 IS - 15 SN - 0169-409X, 0169-409X KW - Biotechnology Research Abstracts (through 1992) KW - Drug delivery KW - Ions KW - Macromolecules KW - Perfusion KW - Monoclonal antibodies KW - polyamidoamines KW - Gadolinium KW - Magnetic resonance imaging KW - Hydrophobicity KW - Reticuloendothelial system KW - Pharmacokinetics KW - Neutrons KW - Blood KW - Avidin KW - Permeability KW - Reviews KW - Computed tomography KW - Liver KW - Kidney KW - Contrast media KW - Iodine KW - Excretion KW - Vascular system KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20219549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advanced+Drug+Delivery+Reviews&rft.atitle=Nano-sized+MRI+contrast+agents+with+dendrimer+cores&rft.au=Kobayashi%2C+Hisataka%3BBrechbiel%2C+Martin+W&rft.aulast=Kobayashi&rft.aufirst=Hisataka&rft.date=2005-12-01&rft.volume=57&rft.issue=15&rft.spage=2271&rft.isbn=&rft.btitle=&rft.title=Advanced+Drug+Delivery+Reviews&rft.issn=0169409X&rft_id=info:doi/10.1016%2Fj.addr.2005.09.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Contrast media; Magnetic resonance imaging; Kidney; Gadolinium; Liver; Vascular system; Macromolecules; Hydrophobicity; Reticuloendothelial system; Neutrons; Ions; Perfusion; Excretion; Permeability; Reviews; Avidin; Monoclonal antibodies; Iodine; Drug delivery; Pharmacokinetics; polyamidoamines; Computed tomography; Blood DO - http://dx.doi.org/10.1016/j.addr.2005.09.016 ER - TY - JOUR T1 - Replication of Coxiella burnetii Is Inhibited in CHO K-1 Cells Treated with Inhibitors of Cholesterol Metabolism AN - 20198015; 6715703 AB - Coxiella burnetii directs the synthesis of a large parasitophorous vacuole (PV) that is required for its replication. While some lysosomal characteristics of the PV have been described, the origin and composition of the PV membrane remain largely undefined. Cholesterol is an essential component of mammalian membranes where it lends mechanical stability and serves as a platform for signaling proteins. Using infected Chinese hamster ovary cells as a model, we examined whether cholesterol is trafficked to the C. burnetii PV membrane and the effects of inhibitors of cholesterol metabolism on C. burnetii replication. When infected cells were stained with filipin, a fluorescent polyene antifungal agent that binds cholesterol, obvious staining of PV was observed indicating the PV membrane is cholesterol-rich. Furthermore, replication of C. burnetii was significantly inhibited in cells treated with the cholesterol metabolism inhibitors lovastatin, ketoconazole, imipramine, progesterone, and U18666A. These data suggest that cholesterol is an important component of the C. burnetii PV membrane and that normal cellular cholesterol metabolism is required for optimal C. burnetii replication. JF - Annals of the New York Academy of Sciences AU - Howe, Dale AU - Heinzen, Robert A AD - Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 123 EP - 129 PB - New York Academy of Sciences, 2 East 63rd Street New York NY 10021 USA, [mailto:publications@nyas.org], [URL:http://www.nyas.org] VL - 1063 SN - 0077-8923, 0077-8923 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology KW - Antifungal agents KW - Data processing KW - Progesterone KW - Replication KW - Cholesterol KW - Ketoconazole KW - Lipid metabolism KW - parasitophorous vacuole KW - Coxiella burnetii KW - polyenes KW - imipramine KW - Lovastatin KW - Signal transduction KW - J 02320:Cell Biology KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20198015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Replication+of+Coxiella+burnetii+Is+Inhibited+in+CHO+K-1+Cells+Treated+with+Inhibitors+of+Cholesterol+Metabolism&rft.au=Howe%2C+Dale%3BHeinzen%2C+Robert+A&rft.aulast=Howe&rft.aufirst=Dale&rft.date=2005-12-01&rft.volume=1063&rft.issue=&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - parasitophorous vacuole; Antifungal agents; Data processing; Progesterone; imipramine; polyenes; Replication; Cholesterol; Ketoconazole; Lovastatin; Signal transduction; Lipid metabolism; Coxiella burnetii ER - TY - JOUR T1 - Immunochemical detection of flucloxacillin adduct formation in livers of treated rats AN - 20193767; 6906342 AB - Flucloxacillin is a semi-synthetic penicillin widely used in the prophylaxis and treatment of staphylococcal infections. Severe liver reactions, characterised by delayed cholestatic hepatitis and a prolonged course of recovery, are associated with flucloxacillin therapy. Clinical findings are suggestive of an immune mediated reaction but there exists little supporting experimental evidence. The formation of drug modified hepatic protein adducts has been proposed to play an important role in the hepatotoxicity of many drugs. The aim of the present study was to investigate whether flucloxacillin treatment results in adduct formation in vivo. Flucloxacillin was conjugated to rabbit serum albumin by formation of a penicilloyl determinant and used as an immunogen to raise a polyclonal antiserum specific for flucloxacillin-modified proteins. Antibody specificity was confirmed by competitive enzyme-linked immunosorbent assay (ELISA) with free drug. The antiserum was used in combination with western blotting to detect adduct formation in the livers of flucloxacillin treated rats. Western blot analysis of rat liver subcellular fractions revealed the formation of six flucloxacillin adducts in various subcellular fractions. These studies demonstrate for the first time that treatment with flucloxacillin results in the formation of hepatic protein adducts. JF - Toxicology AU - Carey, Michelle A AU - Van Pelt, Frank NAM AD - Department of Pharmacology & Therapeutics, University College Cork, Ireland, carey1@niehs.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 41 EP - 48 PB - Elsevier Science Ireland Ltd., P.O. Box 85 Limerick Ireland VL - 216 IS - 1 SN - 0300-483X, 0300-483X KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Toxicology Abstracts KW - Flucloxacillin KW - Cholestasis KW - Drug-adduct KW - Immunoblotting KW - ELISA KW - Western blotting KW - Enzyme-linked immunosorbent assay KW - Infection KW - Immunosuppressive agents KW - Penicillin KW - hepatotoxicity KW - Hepatitis KW - Antibodies KW - Protein adducts KW - Albumin KW - Prophylaxis KW - Liver KW - Drugs KW - V 22350:Immunology KW - X 24115:Pathology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20193767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Immunochemical+detection+of+flucloxacillin+adduct+formation+in+livers+of+treated+rats&rft.au=Carey%2C+Michelle+A%3BVan+Pelt%2C+Frank+NAM&rft.aulast=Carey&rft.aufirst=Michelle&rft.date=2005-12-01&rft.volume=216&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2005.07.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Western blotting; Enzyme-linked immunosorbent assay; Infection; Immunosuppressive agents; hepatotoxicity; Penicillin; Hepatitis; Antibodies; Protein adducts; Albumin; Liver; Prophylaxis; Flucloxacillin; Drugs DO - http://dx.doi.org/10.1016/j.tox.2005.07.015 ER - TY - JOUR T1 - An amino acid substitution in a capsid protein enhances phage survival in mouse circulatory system more than a 1000-fold AN - 20156733; 6634439 AB - In experiments with germ free mice, free from adaptive antibodies to the bacterial virus lambda phage, titers of the virus in the circulatory system have been reported to decrease by more than 10 super(9)pfu within 48h of intraperitoneal intravenous or oral administration. Based on these observations, serial passage techniques have been used to select lambda phage mutants, with 13,000-16,000-fold greater capacity to remain in the mouse circulatory system 24h after intraperitoneal injection. In these prior studies the ''long-circulating'' phage, designated lambda Argo phage, had at least three mutations including one in the major phage capsid (E) protein, which resulted in the change of glutamic acid to a lysine at residue 158. In the current study, we demonstrate that this single specific substitution in the E protein is sufficient to confer the ''long-circulating'' phenotype. The isogenic pair of phage developed in this study consisting of the long-circulating marker-rescued lambda Argo phage, and the parental wild type phage can be used for studies of viral recognition mechanisms of the innate immune system and for the development of more effective antibacterial therapeutic phage strains. JF - Virus Research AU - Vitiello, CL AU - Merril, C R AU - Adhya, S AD - National Institutes of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA, merrilc@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 101 EP - 103 VL - 114 IS - 1-2 SN - 0168-1702, 0168-1702 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Phages KW - Capsids KW - Intravenous administration KW - Amino acid substitution KW - Immune system KW - Oral administration KW - Survival KW - Lysine KW - Antibodies KW - double prime E protein KW - Glutamic acid KW - Mutation KW - Capsid protein KW - Circulatory system KW - V 22070:Phage-host interactions including lysogeny & transduction KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20156733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virus+Research&rft.atitle=An+amino+acid+substitution+in+a+capsid+protein+enhances+phage+survival+in+mouse+circulatory+system+more+than+a+1000-fold&rft.au=Vitiello%2C+CL%3BMerril%2C+C+R%3BAdhya%2C+S&rft.aulast=Vitiello&rft.aufirst=CL&rft.date=2005-12-01&rft.volume=114&rft.issue=1-2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Virus+Research&rft.issn=01681702&rft_id=info:doi/10.1016%2Fj.virusres.2005.05.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Capsids; Phages; Intravenous administration; Amino acid substitution; Immune system; Oral administration; Lysine; Survival; Antibodies; double prime E protein; Glutamic acid; Mutation; Circulatory system; Capsid protein DO - http://dx.doi.org/10.1016/j.virusres.2005.05.014 ER - TY - JOUR T1 - Population Pharmacokinetics of Amphotericin B Lipid Complex in Neonates AN - 19983169; 7139858 AB - The pharmacokinetics of amphotericin B lipid complex (ABLC) were investigated in neonates with invasive candidiasis enrolled in a phase II multicenter trial. Sparse blood (153 samples; 1 to 9 per patient, 1 to 254 h after the dose) and random urine and cerebrospinal fluid (CSF) samples of 28 neonates (median weight [WT], 1.06 kg; range, 0.48 to 4.9 kg; median gestational age, 27 weeks; range, 24 to 41 weeks) were analyzed. Patients received intravenous ABLC at 2.5 (n = 15) or 5 (n = 13) mg/kg of body weight once a day over 1 or 2 h, respectively, for a median of 21 days (range, 4 to 47 days). Concentrations of amphotericin B were quantified as total drug by high-performance liquid chromatography. Blood data for time after dose (TAD) of 24 h revealed a terminal half-life of 395 h. Mean concentrations in the urine after 1, 2, and 3 weeks ranged from 0.082 to 0.430 mu g/ml, and those in CSF ranged from undetectable to 0.074 mu g/ml. The disposition of ABLC in neonates was similar to that observed in other age groups: weight was the only factor that influenced clearance. Based on these results and previously published safety and efficacy data, we recommend a daily dosage between 2.5 and 5.0 mg/kg for treatment of invasive Candida infections in neonates. JF - Antimicrobial Agents & Chemotherapy AU - Wuerthwein, Gudrun AU - Groll, Andreas H AU - Hempel, Georg AU - Adler-Shohet, Felice C AU - Lieberman, Jay M AU - Walsh, Thomas J AD - Infectious Disease Research Program, Center for Bone Marrow Transplantation and Department of Pediatric Hematology/Oncology, Children's University Hospital, Muenster, Federal Republic of Germany. Clinical Pharmacokinetics Section, Coordinating Centre for Clinical Trials (KKS), University Hospital, Muenster, Federal Republic of Germany. Millers Children's Hospital, Long Beach, California. Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 5092 EP - 5098 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 49 IS - 12 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - High-performance liquid chromatography KW - Amphotericin B KW - Intravenous administration KW - Age KW - Gestational age KW - Mathematical models KW - Data processing KW - Candidiasis KW - Lipids KW - Candida KW - Disposition KW - Infection KW - Clinical trials KW - Pharmacokinetics KW - Antimicrobial agents KW - Models KW - Blood KW - Cerebrospinal fluid KW - Body weight KW - Urine KW - Neonates KW - Drugs KW - A 01340:Antibiotics & Antimicrobials KW - K 03400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19983169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Population+Pharmacokinetics+of+Amphotericin+B+Lipid+Complex+in+Neonates&rft.au=Wuerthwein%2C+Gudrun%3BGroll%2C+Andreas+H%3BHempel%2C+Georg%3BAdler-Shohet%2C+Felice+C%3BLieberman%2C+Jay+M%3BWalsh%2C+Thomas+J&rft.aulast=Wuerthwein&rft.aufirst=Gudrun&rft.date=2005-12-01&rft.volume=49&rft.issue=12&rft.spage=5092&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Amphotericin B; Age; Intravenous administration; Data processing; Mathematical models; Gestational age; Candidiasis; Lipids; Disposition; Infection; Clinical trials; Pharmacokinetics; Models; Antimicrobial agents; Blood; Cerebrospinal fluid; Body weight; Urine; Neonates; Drugs; Candida ER - TY - JOUR T1 - The Conserved Poxvirus L3 Virion Protein Is Required for Transcription of Vaccinia Virus Early Genes AN - 19964683; 7144483 AB - We provide the initial characterization of the product of the vaccinia virus L3L open reading frame (VACWR090), which is conserved in all sequenced members of the poxvirus family. The predicted polypeptide contains no motifs or other features that provided a clue to the role of the L3 protein, and no functional information was available regarding a homolog discovered in Plasmodium falciparum. The L3 protein was expressed following viral DNA replication, a finding consistent with a putative late promoter sequence, and was packaged as a non-membrane protein in mature virus particles. A recombinant virus, in which the L3L gene was regulated by the Escherichia coli lac operator/repressor system, had a conditional lethal phenotype. The virus replicated in the presence of inducer, but in its absence, the yields of infectious virus were reduced by 99%. When cells were infected without inducer, however, no defect in gene expression or morphogenesis was noted. Virus particles lacking L3, which assembled in the absence of inducer, were indistinguishable from wild-type virions with regard to morphology, major structural proteins, and DNA content but were noninfectious. L3-deficient virions were able to bind and penetrate cells but produced extremely small amounts of viral early mRNA. A defect in transcription was demonstrated by in vitro studies with permeabilized virions, but soluble extracts of L3-deficient virions showed normal levels of template-dependent transcriptional activity, indicating that only transcription of the packaged genome is impaired. JF - Journal of Virology AU - Resch, Wolfgang AU - Moss, Bernard AD - Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2005/12/01/ PY - 2005 DA - 2005 Dec 01 SP - 14719 EP - 14729 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 79 IS - 23 SN - 0022-538X, 0022-538X KW - Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Virions KW - Genomes KW - DNA biosynthesis KW - Replication KW - Nucleotide sequence KW - Morphogenesis KW - Transcription KW - Plasmodium falciparum KW - Structural proteins KW - Operators KW - Promoters KW - Vaccinia virus KW - Poxvirus KW - Escherichia coli KW - Repressors KW - Open reading frames KW - N 14820:DNA Metabolism & Structure KW - J 02320:Cell Biology KW - G 07770:Bacteria KW - V 22310:Genetics, Taxonomy & Structure KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19964683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=The+Conserved+Poxvirus+L3+Virion+Protein+Is+Required+for+Transcription+of+Vaccinia+Virus+Early+Genes&rft.au=Resch%2C+Wolfgang%3BMoss%2C+Bernard&rft.aulast=Resch&rft.aufirst=Wolfgang&rft.date=2005-12-01&rft.volume=79&rft.issue=23&rft.spage=14719&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Operators; Genomes; Virions; DNA biosynthesis; Promoters; Replication; Nucleotide sequence; Morphogenesis; Transcription; Repressors; Structural proteins; Open reading frames; Vaccinia virus; Poxvirus; Escherichia coli; Plasmodium falciparum ER - TY - JOUR T1 - Lack of Dendritic Cell Maturation Following Infection by Coxiella burnetii Synthesizing Different Lipopolysaccharide Chemotypes AN - 19939656; 6715708 AB - Coxiella burnetii is an obligate intracellular bacterium and the etiologic agent of the zoonotic disease Q fever. Symptomatic infection is normally characterized by flu-like symptoms; however, in some cases, a persistent infection can ensue that may reactivate months or years after initial exposure to cause chronic disease. The mechanisms by which this obligate parasite evades clearance by the host immune response during persistent infection are unknown. We have previously demonstrated that lipopolysaccharide (LPS) length is critical in determining the response of human dendritic cells (DC) to C. burnetii. Here, we investigated whether LPS chemotype affects DC maturation or activation. Immature human DC were infected with three virulent strains of C. burnetii (Nine Mile phase I, S, or Priscilla) that produce chemically distinct LPS molecules. None of these strains stimulated significant upregulation of cell surface markers of DC maturation. Moreover, these strains were equally deficient in inducing DC IL-12p70 production or p38 mitogen-activated protein kinase phosphorylation. Infection of DC by virulent C. burnetii without stimulating significant maturation or inflammatory cytokine production may be a mechanism of immune evasion that results in persistent infection of an otherwise immunocompetent host. Our data indicate that LPS chemotype is not a determinant of DC maturation or cytokine production in response to C. burnetii. JF - Annals of the New York Academy of Sciences AU - Shannon, Jeffrey G AU - Howe, Dale AU - Heinzen, Robert A AD - Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840, USA Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 154 EP - 160 PB - New York Academy of Sciences, 2 East 63rd Street New York NY 10021 USA, [mailto:publications@nyas.org], [URL:http://www.nyas.org] VL - 1063 SN - 0077-8923, 0077-8923 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Parasites KW - Cell surface KW - MAP kinase KW - Data processing KW - double prime Q fever KW - Persistent infection KW - Cell activation KW - Inflammation KW - Coxiella burnetii KW - Interleukin 12 KW - Dendritic cells KW - Phosphorylation KW - Chronic infection KW - Cytokines KW - Lipopolysaccharides KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19939656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Lack+of+Dendritic+Cell+Maturation+Following+Infection+by+Coxiella+burnetii+Synthesizing+Different+Lipopolysaccharide+Chemotypes&rft.au=Shannon%2C+Jeffrey+G%3BHowe%2C+Dale%3BHeinzen%2C+Robert+A&rft.aulast=Shannon&rft.aufirst=Jeffrey&rft.date=2005-12-01&rft.volume=1063&rft.issue=&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell surface; Parasites; MAP kinase; Data processing; Persistent infection; double prime Q fever; Inflammation; Cell activation; Dendritic cells; Interleukin 12; Phosphorylation; Chronic infection; Lipopolysaccharides; Cytokines; Coxiella burnetii ER - TY - JOUR T1 - BMP2 and FGF2 cooperate to induce neural-crest-like fates from fetal and adult CNS stem cells AN - 19931233; 6577582 AB - CNS stem cells are best characterized by their ability to self-renew and to generate multiple differentiated derivatives, but the effect of mitogenic signals, such as fibroblast growth factor 2 (FGF2), on the positional identity of these cells is not well understood. Here, we report that bone morphogenetic protein 2 (BMP2) induces telencephalic CNS stem cells to fates characteristic of neural crest and choroid plexus mesenchyme, a cell type of undetermined lineage in rodents. This induction occurs both in dissociated cell culture and cortical explants of embryonic day 14.5 (E14.5) embryos, but only when cells have been exposed to FGF2. Neither EGF nor IGF1 can substitute for FGF2. An early step in this response is activation of beta -catenin, a mediator of Wnt activity. The CNS stem cells first undergo an epithelial-to-mesenchymal transition and subsequently differentiate to smooth-muscle and non-CNS glia cells. Similar responses are seen with stem cells from E14.5 cortex, E18.5 cortex and adult subventricular zone, but with a progressive shift toward gliogenesis that is characteristic of normal development. These data indicate that FGF2 confers competence for dorsalization independently of its mitogenic action. This rapid and efficient induction of dorsal fates may allow identification of positional identity effectors that are co-regulated by FGF2 and BMP2. JF - Journal of Cell Science AU - Sailer, Martin HM AU - Hazel, Thomas G AU - Panchision, David M AU - Hoeppner, Daniel J AU - Schwab, Martin E AU - McKay, Ronald DG AD - Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland. Department of Biology, Swiss Federal Institute of Technology, 8057 Zurich, Switzerland. Center for Neuroscience Research, Children's Research Institute, Children's National Medical Center, Washington DC, 20010, USA Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 5849 EP - 5860 PB - Company of Biologists, 140 Cowley Road Cambridge CB4 0DL UK, [URL:http://www.biologists.com/web/index.html] VL - 118 IS - 24 SN - 0021-9533, 0021-9533 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Smooth muscle KW - Central nervous system KW - Insulin-like growth factor I KW - Wnt protein KW - Data processing KW - subventricular zone KW - Cell culture KW - Choroid plexus KW - Fetuses KW - Stem cells KW - catenin KW - Glia KW - Telencephalon KW - Embryos KW - Bone morphogenetic protein 2 KW - Epidermal growth factor KW - Mesenchyme KW - Fibroblast growth factor 2 KW - Explants KW - Neural crest KW - Gliogenesis KW - N3 11070:Neurochemistry and cellular biology KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19931233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cell+Science&rft.atitle=BMP2+and+FGF2+cooperate+to+induce+neural-crest-like+fates+from+fetal+and+adult+CNS+stem+cells&rft.au=Sailer%2C+Martin+HM%3BHazel%2C+Thomas+G%3BPanchision%2C+David+M%3BHoeppner%2C+Daniel+J%3BSchwab%2C+Martin+E%3BMcKay%2C+Ronald+DG&rft.aulast=Sailer&rft.aufirst=Martin&rft.date=2005-12-01&rft.volume=118&rft.issue=24&rft.spage=5849&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cell+Science&rft.issn=00219533&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Smooth muscle; Insulin-like growth factor I; Central nervous system; Data processing; Wnt protein; subventricular zone; Cell culture; Choroid plexus; Fetuses; Stem cells; catenin; Glia; Embryos; Telencephalon; Bone morphogenetic protein 2; Fibroblast growth factor 2; Mesenchyme; Epidermal growth factor; Explants; Gliogenesis; Neural crest ER - TY - JOUR T1 - Crystal structure of human T cell leukemia virus protease, a novel target for anticancer drug design AN - 19924921; 6578666 AB - The successful development of a number of HIV-1 protease (PR) inhibitors for the treatment of AIDS has validated the utilization of retroviral PRs as drug targets and necessitated their detailed structural study. Here we report the structure of a complex of human T cell leukemia virus type 1 (HTLV-1) PR with a substrate-based inhibitor bound in subsites P5 through P5'. Although HTLV-1 PR exhibits an overall fold similar to other retroviral PRs, significant structural differences are present in several loop areas, which include the functionally important flaps, previously considered to be structurally highly conserved. Potential key residues responsible for the resistance of HTLV-1 PR to anti-HIV drugs are identified. We expect that the knowledge accumulated during the development of anti-HIV drugs, particularly in overcoming drug resistance, will help in designing a novel class of antileukemia drugs targeting HTLV-1 PR and in predicting their drug-resistance profile. The structure presented here can be used as a starting point for the development of such anticancer therapies. JF - Proceedings of the National Academy of Sciences, USA AU - Li, Mi AU - Laco, Gary S AU - Jaskolski, Mariusz AU - Rozycki, Jan AU - Alexandratos, Jerry AU - Wlodawer, Alexander AU - Gustchina, Alla AD - Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, MD 21702 Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 18332 EP - 18337 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 102 IS - 51 SN - 0027-8424, 0027-8424 KW - HIV-1 KW - Biotechnology and Bioengineering Abstracts; Oncogenes & Growth Factors Abstracts; Virology & AIDS Abstracts KW - Drug delivery KW - Acquired immune deficiency syndrome KW - Human immunodeficiency virus KW - Drug resistance KW - Human T-lymphotropic virus 1 KW - Human immunodeficiency virus 1 KW - Proteinase inhibitors KW - Lymphocytes T KW - Crystal structure KW - Drug development KW - Proteinase KW - V 22032:Viral proteins KW - W 30915:Pharmaceuticals & Vaccines KW - B 26285:Retroviruses UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19924921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Crystal+structure+of+human+T+cell+leukemia+virus+protease%2C+a+novel+target+for+anticancer+drug+design&rft.au=Li%2C+Mi%3BLaco%2C+Gary+S%3BJaskolski%2C+Mariusz%3BRozycki%2C+Jan%3BAlexandratos%2C+Jerry%3BWlodawer%2C+Alexander%3BGustchina%2C+Alla&rft.aulast=Li&rft.aufirst=Mi&rft.date=2005-12-01&rft.volume=102&rft.issue=51&rft.spage=18332&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Drug delivery; Acquired immune deficiency syndrome; Drug resistance; Proteinase inhibitors; Crystal structure; Lymphocytes T; Proteinase; Drug development; Human immunodeficiency virus; Human immunodeficiency virus 1; Human T-lymphotropic virus 1 ER - TY - JOUR T1 - Potent Antiviral Activity of North-Methanocarbathymidine against Kaposi's Sarcoma-Associated Herpesvirus AN - 19839571; 7139840 AB - Kaposi's sarcoma-associated herpesvirus (KSHV) infection is a prerequisite for the development of Kaposi's sarcoma (KS). Blocking lytic KSHV replication may hinder KS tumorigenesis. Here, we report potent in vitro anti-KSHV activity of 2'-exo-methanocarbathymidine [North-methanocarbathymidine (N-MCT)], a thymidine analog with a pseudosugar ring locked in the northern conformation, which has previously been shown to block the replication of herpes simplex virus types 1 and 2. N-MCT inhibited KSHV virion production in lytically induced KSHV-infected BCBL-1 cells with a substantially lower 50% inhibitory concentration (IC sub(50)) than those of cidofovir (CDV) and ganciclovir (GCV) (IC sub(50), mean plus or minus standard deviation: 0.08 plus or minus 0.03, 0.42 plus or minus 0.07, and 0.96 plus or minus 0.49 mu M for N-MCT, CDV, and GCV, respectively). The reduction in KSHV virion production was accompanied by a corresponding decrease in KSHV DNA levels in the N-MCT-treated BCBL-1 cells, indicating that the compound blocked lytic KSHV DNA replication. A time- and dose-dependent accumulation of N-MCT-triphosphate (TP) was demonstrated in lytically induced BCBL-1 cells, while uninfected cells showed virtually no accumulation. The levels of N-MCT-TP were significantly decreased in the presence of 5'-ethynylthymidine, a potent inhibitor of herpesvirus thymidine kinase, resulting in the abrogation of anti-KSHV activity of N-MCT. N-MCT-TP more effectively blocked in vitro DNA synthesis by KSHV DNA polymerase with an IC sub(50) of 6.24 plus or minus 0.08 mu M (mean plus or minus standard deviation) compared to CDV-diphosphate (14.70 plus or minus 2.47 mu M) or GCV-TP (24.59 plus or minus 5.60 mu M). Taken together, N-MCT is a highly potent and target-specific anti-KSHV agent which inhibits lytic KSHV DNA synthesis through its triphosphate metabolite produced in KSHV-infected cells expressing a virally encoded thymidine kinase. JF - Antimicrobial Agents & Chemotherapy AU - Zhu, Weimin AU - Burnette, Angela AU - Dorjsuren, Dorjbal AU - Roberts, Paula E AU - Huleihel, Mahmoud AU - Shoemaker, Robert H AU - Marquez, Victor E AU - Agbaria, Riad AU - Sei, Shizuko AD - Laboratory of Antiviral Drug Mechanisms, SAIC-Frederick, Frederick, Maryland. National Institute for Biotechnology and Department of Virology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. Screening Technologies Branch, Developmental Therapeutics Program, NCI-Frederick, Frederick, Maryland. Laboratory of Medicinal Chemistry, Center for Cancer Research, NCI-Frederick, Frederick, Maryland. Department of Clinical Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 4965 EP - 4973 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 49 IS - 12 SN - 0066-4804, 0066-4804 KW - HSV KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Cidofovir KW - Virions KW - DNA biosynthesis KW - Human herpesvirus 8 KW - Replication KW - Tumorigenesis KW - Kaposi's sarcoma-associated herpesvirus KW - Metabolites KW - Ganciclovir KW - Thymidine kinase KW - Infection KW - Antiviral activity KW - Antimicrobial agents KW - Standard deviation KW - Kaposi's sarcoma KW - DNA-directed DNA polymerase KW - Herpes simplex virus KW - Thymidine KW - Conformation KW - A 01340:Antibiotics & Antimicrobials KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19839571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Potent+Antiviral+Activity+of+North-Methanocarbathymidine+against+Kaposi%27s+Sarcoma-Associated+Herpesvirus&rft.au=Zhu%2C+Weimin%3BBurnette%2C+Angela%3BDorjsuren%2C+Dorjbal%3BRoberts%2C+Paula+E%3BHuleihel%2C+Mahmoud%3BShoemaker%2C+Robert+H%3BMarquez%2C+Victor+E%3BAgbaria%2C+Riad%3BSei%2C+Shizuko&rft.aulast=Zhu&rft.aufirst=Weimin&rft.date=2005-12-01&rft.volume=49&rft.issue=12&rft.spage=4965&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Virions; Cidofovir; DNA biosynthesis; Replication; Tumorigenesis; Thymidine kinase; Ganciclovir; Metabolites; Antiviral activity; Infection; Antimicrobial agents; Standard deviation; Kaposi's sarcoma; DNA-directed DNA polymerase; Thymidine; Conformation; Human herpesvirus 8; Kaposi's sarcoma-associated herpesvirus; Herpes simplex virus ER - TY - JOUR T1 - Enzymatic Redesigning of Biologically Active Heparan Sulfate AN - 19825825; 6577430 AB - Heparan sulfate carries a wide range of biological activities, regulating blood coagulation, cell differentiation, and inflammatory responses. The sulfation patterns of the polysaccharide are essential for the biological activities. In this study, we report an enzymatic method for the sulfation of multimilligram amounts of heparan sulfate with specific functions using immobilized sulfotransferases combined with a 3'-phosphoadenosine 5'-phosphosulfate regeneration system. By selecting appropriate enzymatic modification steps, an inactive precursor has been converted to the heparan sulfate having three distinct biological activities, associated with binding to antithrombin, fibroblast growth factor-2, and herpes simplex virus envelope glycoprotein D. Because the recombinant sulfotransferases are expressed in bacteria, and the method uses a low cost sulfo donor, it can be readily utilized to synthesize large quantities of anticoagulant heparin drug or other biologically active heparan sulfates. JF - Journal of Biological Chemistry AU - Chen, Jinghua AU - Avci, Fikri Y AU - Munoz, Eva M AU - McDowell, Lynda M AU - Chen, Miao AU - Pedersen, Lars C AU - Zhang, Lijuan AU - Linhardt, Robert J AU - Liu, Jian AD - Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, the Department of Chemistry and Chemical Biology, Biology and Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, the Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, and the Laboratory of Structural Biology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709 Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 42817 EP - 42825 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 280 IS - 52 SN - 0021-9258, 0021-9258 KW - HSV KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Anticoagulants KW - Sulfotransferase KW - Polysaccharides KW - Heparan sulfate KW - Inflammation KW - glycoprotein D KW - Differentiation KW - Blood coagulation KW - Envelopes KW - Fibroblast growth factor 2 KW - Herpes simplex virus KW - Drugs KW - Heparin KW - antithrombin KW - W 30965:Miscellaneous, Reviews KW - V 22310:Genetics, Taxonomy & Structure KW - W3 33390:Products: Others UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19825825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Enzymatic+Redesigning+of+Biologically+Active+Heparan+Sulfate&rft.au=Chen%2C+Jinghua%3BAvci%2C+Fikri+Y%3BMunoz%2C+Eva+M%3BMcDowell%2C+Lynda+M%3BChen%2C+Miao%3BPedersen%2C+Lars+C%3BZhang%2C+Lijuan%3BLinhardt%2C+Robert+J%3BLiu%2C+Jian&rft.aulast=Chen&rft.aufirst=Jinghua&rft.date=2005-12-01&rft.volume=280&rft.issue=52&rft.spage=42817&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Sulfotransferase; Anticoagulants; Polysaccharides; Heparan sulfate; glycoprotein D; Inflammation; Differentiation; Blood coagulation; Envelopes; Fibroblast growth factor 2; Heparin; Drugs; antithrombin; Herpes simplex virus ER - TY - JOUR T1 - A Role for TLRs in the Regulation of Immune Cell Migration by First Trimester Trophoblast Cells AN - 19820311; 6577908 AB - Normal pregnancy is characterized by the presence of innate immune cells at the maternal-fetal interface. Originally, it was postulated that the presence of these leukocytes was due to an immune response toward paternal Ags expressed by the invading trophoblasts. Instead, we and others postulate that these innate immune cells are necessary for successful implantation and pregnancy. However, elevated leukocyte infiltration may be an underlying cause of pregnancy complications, such as preterm labor or preeclampsia. Furthermore, such conditions have been attributed to an intrauterine infection. Therefore, we hypothesize that first trimester trophoblast cells, upon recognition of microbes through TLRs, may coordinate an immune response by recruiting cells of the innate immune system to the maternal-fetal interface. In this study, we have demonstrated that human first trimester trophoblast cells constitutively secrete the chemokines growth-related oncogene, growth-related oncogene alpha , IL-8, and MCP-1 and are able to recruit monocytes and NK cells, and to a lesser degree, neutrophils. Following the ligation of TLR-3 by the viral ligand, poly(I:C), or TLR-4 by bacterial LPS, trophoblast secretion of chemokines is significantly increased and this in turn results in elevated monocyte and neutrophil chemotaxis. In addition, TLR-3 stimulation also induces trophoblast cells to secrete RANTES. These results suggest a novel mechanism by which first trimester trophoblast cells may differentially modulate the maternal immune system during normal pregnancy and in the presence of an intrauterine infection. Such altered trophoblast cell responses might contribute to the pathogenesis of certain pregnancy complications. JF - Journal of Immunology AU - Abrahams, Vikki M AU - Visintin, Irene AU - Aldo, Paulomi B AU - Guller, Seth AU - Romero, Roberto AU - Mor, Gil AD - Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520. Perinatology Research Branch, National Institute of Child Health and Human Development, Detroit, MI 48202 Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 8096 EP - 8104 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 175 IS - 12 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Chemokines KW - Monocyte chemoattractant protein 1 KW - Immune system KW - Leukocytes (neutrophilic) KW - Natural killer cells KW - Trophoblasts KW - RANTES KW - Infection KW - Chemotaxis KW - Interleukin 8 KW - Pregnancy KW - Gro protein KW - Pregnancy complications KW - Pre-eclampsia KW - Lipopolysaccharides KW - Immune response KW - Monocytes KW - Cell migration KW - V 22350:Immunology KW - J 02350:Immunology KW - F 06378:Reproductive System: Clinical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19820311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=A+Role+for+TLRs+in+the+Regulation+of+Immune+Cell+Migration+by+First+Trimester+Trophoblast+Cells&rft.au=Abrahams%2C+Vikki+M%3BVisintin%2C+Irene%3BAldo%2C+Paulomi+B%3BGuller%2C+Seth%3BRomero%2C+Roberto%3BMor%2C+Gil&rft.aulast=Abrahams&rft.aufirst=Vikki&rft.date=2005-12-01&rft.volume=175&rft.issue=12&rft.spage=8096&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-01-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Chemokines; Monocyte chemoattractant protein 1; Immune system; Natural killer cells; Leukocytes (neutrophilic); RANTES; Trophoblasts; Infection; Chemotaxis; Interleukin 8; Pregnancy; Pregnancy complications; Gro protein; Pre-eclampsia; Lipopolysaccharides; Cell migration; Monocytes; Immune response ER - TY - JOUR T1 - Invasive Infections with Haemophilus influenzae Serotype a Containing an IS1016-bexA Partial Deletion: Possible Association with Virulence AN - 19773333; 6841846 AB - Recent reports of invasive Haemophilus influenzae non-b capsular serotypes in the era since development of conjugate vaccines have prompted concern about serotype replacement. Unusual clusters of invasive infection due to H. influenzae serotype a with clinical features that resemble those of infection due to H. influenzae serotype b have been described. A unique feature often associated with more-virulent H. influenzae serotype a isolates is the IS1016-bexA partial deletion, which was previously identified in the capsule locus of H. influenzae serotype b strains. We report the clinical, epidemiologic, and molecular genetic features of 2 cases of severe disease caused by H. influenzae serotype a. Invasive H. influenzae isolates were serotyped with standard serological methods, and molecular typing was done with PCR. The capsular genotype of each isolate was characterized with PCR, partial sequencing, and Southern blot hybridization. Further strain typing was performed with pulsed-field gel electrophoresis. We identified 2 children with severe invasive disease due to H. influenzae serotype a. Both H. influenzae serotype a isolates contained the identical pulsed-field gel electrophoresis pattern and capsular genotype. An IS1016-bexA partial deletion in the capsule gene locus similar to that found in H. influenzae serotype b was identified in both isolates by means of PCR and sequencing of the IS1016-bexA junction. We describe 2 cases of severe invasive disease due to H. influenzae serotype a with the putative virulence-enhancing IS1016-bexA partial deletion and duplication of the capsule locus. Our data support the hypothesis that this mutation may be associated with virulence in non-b capsular serotypes of H. influenzae. JF - Clinical Infectious Diseases AU - Kapogiannis, B G AU - Satola, S AU - Keyserling, H L AU - Farley, M M AD - Pediatric, Adolescent, and Maternal AIDS Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA Y1 - 2005/12/01/ PY - 2005 DA - 2005 Dec 01 SP - e97 EP - e103 VL - 41 IS - 11 SN - 1058-4838, 1058-4838 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology KW - Haemophilus influenzae KW - Serotypes KW - Data processing KW - Genotypes KW - Children KW - Infection KW - Virulence KW - Gene deletion KW - Typing KW - Pulsed-field gel electrophoresis KW - Polymerase chain reaction KW - Vaccines KW - Mutation KW - J 02834:Vaccination and immunization KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19773333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Invasive+Infections+with+Haemophilus+influenzae+Serotype+a+Containing+an+IS1016-bexA+Partial+Deletion%3A+Possible+Association+with+Virulence&rft.au=Kapogiannis%2C+B+G%3BSatola%2C+S%3BKeyserling%2C+H+L%3BFarley%2C+M+M&rft.aulast=Kapogiannis&rft.aufirst=B&rft.date=2005-12-01&rft.volume=41&rft.issue=11&rft.spage=e97&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Virulence; Gene deletion; Data processing; Typing; Serotypes; Pulsed-field gel electrophoresis; Polymerase chain reaction; Vaccines; Genotypes; Infection; Children; Mutation; Haemophilus influenzae ER - TY - JOUR T1 - Cancer Incidence among Male Pesticide Applicators in the Agricultural Health Study Cohort Exposed to Diazinon AN - 19772670; 7140979 AB - Little is known about the potential carcinogenicity associated with routine application of diazinon, a common organophosphate insecticide. The authors explored a possible association of diazinon exposure with cancer risk in the Agricultural Health Study, a prospective cohort of licensed pesticide applicators in Iowa and North Carolina enrolled in 1993-1997. A total of 23,106 male applicators provided information in a self-administered questionnaire. Among 4,961 applicators who reported using diazinon, 301 incident cancer cases were diagnosed during the follow-up period ending December 2002 compared with 968 cases among 18,145 participants who reported no use. Poisson regression was used to calculate rate ratios and 95% confidence intervals. Two quantitative exposure metrics were used: lifetime exposure days and intensity-weighted lifetime exposure days, a measure that incorporates probability of pesticide exposure with lifetime pesticide application frequency. When lifetime exposure days were used, increased risks for the highest tertile of exposure and significant tests for trend for lung cancer and leukemia were observed. No other cancer site showed an association with diazinon for the highest tertile of exposure. Because these results were based on small numbers, additional analyses are necessary as more cases accrue to clarify whether diazinon is associated with cancer risk in humans. JF - American Journal of Epidemiology AU - Beane Freeman, Laura E AU - Bonner, Matthew R AU - Blair, Aaron AU - Hoppin, Jane A AU - Sandler, Dale P AU - Lubin, Jay H AU - Dosemeci, Mustafa AU - Lynch, Charles F AU - Knott, Charles AU - Alavanja, Michael CR AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD Y1 - 2005/12/01/ PY - 2005 DA - 2005 Dec 01 SP - 1070 EP - 1079 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 162 IS - 11 SN - 0002-9262, 0002-9262 KW - Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Agriculture KW - USA, North Carolina KW - Inventories KW - Organophosphates KW - males KW - organophosphates KW - Cancer KW - Pesticide applications KW - Leukemia KW - Insecticides KW - USA, Iowa KW - Carcinogenicity KW - Risk factors KW - Pesticides KW - Diazinon KW - Occupational exposure KW - Lung cancer KW - H 5000:Pesticides KW - R2 23060:Medical and environmental health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19772670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Cancer+Incidence+among+Male+Pesticide+Applicators+in+the+Agricultural+Health+Study+Cohort+Exposed+to+Diazinon&rft.au=Beane+Freeman%2C+Laura+E%3BBonner%2C+Matthew+R%3BBlair%2C+Aaron%3BHoppin%2C+Jane+A%3BSandler%2C+Dale+P%3BLubin%2C+Jay+H%3BDosemeci%2C+Mustafa%3BLynch%2C+Charles+F%3BKnott%2C+Charles%3BAlavanja%2C+Michael+CR&rft.aulast=Beane+Freeman&rft.aufirst=Laura&rft.date=2005-12-01&rft.volume=162&rft.issue=11&rft.spage=1070&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Inventories; Leukemia; Insecticides; Carcinogenicity; Risk factors; Pesticides; organophosphates; Diazinon; Pesticide applications; Lung cancer; Agriculture; Organophosphates; males; Occupational exposure; Cancer; USA, North Carolina; USA, Iowa ER - TY - JOUR T1 - A review of evidence from short-term studies leading to the prediction that diazoaminobenzene (1,3-diphenyltriazine) is a carcinogen AN - 19727108; 7516658 AB - The National Toxicology Program (NTP) is responsible for providing comprehensive toxicology evaluations of substances, while at the same time incorporating approaches to reduce, refine or replace laboratory animals in routine toxicity/carcinogenicity studies. Consistent with this, a series of metabolism studies in rodents and human liver slices, electron spin resonance spectroscopy (ESR) studies, short-term dermal toxicity studies in rodents, and acute bone marrow micronucleus studies in mice were performed on diazoaminobenzene (DAAB, also known as 1,3-diphenyltriazine). These studies demonstrated that DAAB is metabolized and shares similar genotoxic and toxicological properties to the known human carcinogen, benzene, and the known rodent carcinogen, aniline. These data were used to evaluate the potential carcinogenicity of DAAB without doing a 2-year rodent bioassay. Based on this analysis, DAAB was predicted to be carcinogenic if evaluated in a 2-year rodent bioassay. These data were evaluated to support listing DAAB in the NTP Report on Carcinogens as a substance reasonably anticipated to be a human carcinogen. The purpose of this article is to review the data developed for predicting the carcinogenicity of DAAB. Published in 2005 by John Wiley & Sons, Ltd. JF - Journal of Applied Toxicology AU - Bordelon, Nancy R AU - Chhabra, Rajendra AU - Bucher, John R AD - National Toxicology Program, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA, bucher@niehs.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 514 EP - 521 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 25 IS - 6 SN - 0260-437X, 0260-437X KW - Toxicology Abstracts KW - Skin KW - Genotoxicity KW - Laboratory animals KW - Bone marrow KW - Toxicity KW - Carcinogens KW - Spectroscopy KW - Benzene KW - Carcinogenicity KW - Reviews KW - Liver KW - Metabolism KW - Aniline KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19727108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=A+review+of+evidence+from+short-term+studies+leading+to+the+prediction+that+diazoaminobenzene+%281%2C3-diphenyltriazine%29+is+a+carcinogen&rft.au=Bordelon%2C+Nancy+R%3BChhabra%2C+Rajendra%3BBucher%2C+John+R&rft.aulast=Bordelon&rft.aufirst=Nancy&rft.date=2005-12-01&rft.volume=25&rft.issue=6&rft.spage=514&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.1087 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Skin; Genotoxicity; Bone marrow; Laboratory animals; Carcinogens; Toxicity; Spectroscopy; Benzene; Carcinogenicity; Reviews; Liver; Metabolism; Aniline DO - http://dx.doi.org/10.1002/jat.1087 ER - TY - JOUR T1 - n-Alkyl glucopyranosides completely inhibit ultrasound-induced cytolysis AN - 19467651; 7983929 AB - The mechanism(s) responsible for sudden cytolysis observed when cells are exposed to ultrasound could be mechanical and/or free radical in nature. Free radical reactions are initiated in the core and in the interfacial regions of collapsing acoustic cavitation bubbles. Because cyclic sugars are known to inhibit free radical chain reactions, we investigated the effects of n-alkyl- beta -d-glucopyranosides of varying hydrophobicity on ultrasound (1.057 MHz)-induced cytolysis of HL-60 cells in vitro. n-Alkyl glucopyranosides with hexyl- (5 mM), heptyl- (3 mM), or octyl- (2 mM) n-alkyl chains protected 100% of the cell population from ultrasound-induced cytolysis under a range of conditions that resulted in 35 to 100% cytolysis in the absence of glucopyranosides. The protected cell populations also possessed long-term reproductive viability. However, the hydrophilic methyl- beta -d-glucopyranoside could not protect cells, even up to a concentration of 30 mM. Furthermore, none of the glucopyranosides could prevent cytolysis of cells from a mechanically induced shear stress. Spin trapping and electron spin resonance experiments confirmed the presence of inertial cavitation in cell suspensions both in the presence and in the absence of the surfactants. It is concluded that surface-active glucopyranosides efficiently quench cytotoxic radicals and/or their precursors at the gas/solution interface of collapsing cavitation bubbles. JF - Free Radical Biology and Medicine AU - Sostaric, Joe Z AU - Miyoshi, Norio AU - Riesz, Peter AU - Degraff, William G AU - Mitchell, James B AD - Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1002, USA, sostaric.2@osu.edu Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1539 EP - 1548 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 39 IS - 12 SN - 0891-5849, 0891-5849 KW - Biotechnology and Bioengineering Abstracts KW - Free radicals KW - EKW ESR KW - Sonoporation KW - Sonophoresis KW - Sonochemistry KW - Radiolysis KW - HIFU KW - Ultrasound KW - Surfactants KW - HL-60 KW - Protection KW - Sonoprotection KW - Cytolysis KW - Sonolysis KW - Sonication KW - Glucopyranoside KW - Sugars KW - Bioreactors KW - Cell suspensions KW - Sugar KW - Acoustics KW - Hydrophobicity KW - Trapping KW - Mechanical stimuli KW - Cytotoxicity KW - Cavitation KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19467651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+Radical+Biology+and+Medicine&rft.atitle=n-Alkyl+glucopyranosides+completely+inhibit+ultrasound-induced+cytolysis&rft.au=Sostaric%2C+Joe+Z%3BMiyoshi%2C+Norio%3BRiesz%2C+Peter%3BDegraff%2C+William+G%3BMitchell%2C+James+B&rft.aulast=Sostaric&rft.aufirst=Joe&rft.date=2005-12-01&rft.volume=39&rft.issue=12&rft.spage=1539&rft.isbn=&rft.btitle=&rft.title=Free+Radical+Biology+and+Medicine&rft.issn=08915849&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2005.07.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cell suspensions; Sugar; Cytotoxicity; Cavitation; Acoustics; Free radicals; Cytolysis; Hydrophobicity; Trapping; Surfactants; Ultrasound; Mechanical stimuli DO - http://dx.doi.org/10.1016/j.freeradbiomed.2005.07.020 ER - TY - JOUR T1 - Arginine-rich cell penetrating peptides: from endosomal uptake to nuclear delivery AN - 19440765; 6706627 AB - Delivery of macromolecules into living cells by arginine-rich cell penetrating peptides (AR-CPPs) is an important new avenue for the development of novel therapeutic strategies. However, to date the mechanism of this delivery remains elusive. Recent data implicate endocytosis in the internalization of AR-CPPs and their macromolecular cargo and also indicate limited delivery of macromolecules into the cell cytoplasm and nucleus. Different types of endocytosis - clathrin-dependent endocytosis, raft/caveolin-dependent endocytosis and macropinocytosis - are all implicated in the uptake of AR-CPPs and their cargo into different cells. Cationic AR-CPPs dramatically increase uptake of conjugated molecules through efficient binding to surface proteogly-cans. Whether this increase in binding can assure delivery of a sufficient amount of functionally active macromolecules into the cytoplasm and nucleus or whether there is a specific mechanism by which AR-CPPs facilitate the escape of conjugated cargo from endosomes remains to be understood. JF - Cellular and Molecular Life Sciences AU - Melikov, K AU - Chernomordik, LV AD - Section on Membrane Biology, Laboratory of Cellular and Molecular Biophysics, NICHD, National Institutes of Health, Bldg.10/Rm.10D05, 10 Center Drive, Bethesda, Maryland 20892-1855 (USA), melikovk@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 2739 EP - 2749 VL - 62 IS - 23 SN - 1420-682X, 1420-682X KW - Biotechnology and Bioengineering Abstracts KW - Endocytosis KW - endosomes KW - Macromolecules KW - Cytoplasm KW - Nuclei KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19440765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+and+Molecular+Life+Sciences&rft.atitle=Arginine-rich+cell+penetrating+peptides%3A+from+endosomal+uptake+to+nuclear+delivery&rft.au=Melikov%2C+K%3BChernomordik%2C+LV&rft.aulast=Melikov&rft.aufirst=K&rft.date=2005-12-01&rft.volume=62&rft.issue=23&rft.spage=2739&rft.isbn=&rft.btitle=&rft.title=Cellular+and+Molecular+Life+Sciences&rft.issn=1420682X&rft_id=info:doi/10.1007%2Fs00018-005-5293-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Endocytosis; Macromolecules; Nuclei; Cytoplasm; endosomes DO - http://dx.doi.org/10.1007/s00018-005-5293-y ER - TY - JOUR T1 - Finding New Tricks For Old Drugs: An Efficient Route For Public-Sector Drug Discovery AN - 19427848; 6702402 AB - With the annotation of the human genome approaching completion, public- sector researchers-spurred in part by various National Institutes of Health Roadmap Initiatives-have become increasingly engaged in drug discovery and development efforts. Although large and diverse chemical libraries of 'drug- like' compounds can be readily screened to yield chemically novel scaffolds, transforming these 'chemical probes' into drugs is a daunting endeavour. A more efficient approach involves screening libraries of approved and off-patent medications; both phenotypic- and molecular target-based screening of 'old drugs' can readily yield compounds that could be immediately used in clinical trials. Using case studies, we describe how this approach has rapidly identified candidate medications suitable for clinical trials in disorders such as progressive multifocal leukoencephalopathy and amyotrophic lateral sclerosis. This approach has also led to the discovery of the molecular targets responsible for serious drug side effects, thereby allowing efficient 'counter-screening' to avoid these side effects. JF - Nature Reviews: Drug Discovery AU - O'Connor, Kerry A AU - Roth, Bryan L AD - Departments of Biochemistry, Psychiatry, Neurosciences, Comprehensive Cancer Center and National Institute of Mental Health Psychoactive Drug Screening Program, 2109 Adelbert Road, Case Western Reserve University Medical School, Cleveland, Ohio 44106, USA., bryan.roth@case.edu Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1005 EP - 1014 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 4 IS - 12 SN - 1474-1776, 1474-1776 KW - Biotechnology and Bioengineering Abstracts KW - Genomes KW - Drug discovery KW - Amyotrophic lateral sclerosis KW - DNA probes KW - Reviews KW - Drug screening KW - Progressive multifocal leukoencephalopathy KW - Clinical trials KW - Drugs KW - scaffolds KW - Side effects KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19427848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Drug+Discovery&rft.atitle=Finding+New+Tricks+For+Old+Drugs%3A+An+Efficient+Route+For+Public-Sector+Drug+Discovery&rft.au=O%27Connor%2C+Kerry+A%3BRoth%2C+Bryan+L&rft.aulast=O%27Connor&rft.aufirst=Kerry&rft.date=2005-12-01&rft.volume=4&rft.issue=12&rft.spage=1005&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Drug+Discovery&rft.issn=14741776&rft_id=info:doi/10.1038%2Fnrd1900 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Drugs; Drug discovery; Side effects; Clinical trials; Reviews; Genomes; Drug screening; Progressive multifocal leukoencephalopathy; Amyotrophic lateral sclerosis; scaffolds; DNA probes DO - http://dx.doi.org/10.1038/nrd1900 ER - TY - JOUR T1 - Staphylococcal Protein A Deletes B-1a and Marginal Zone B Lymphocytes Expressing Human Immunoglobulins: An Immune Evasion Mechanism AN - 19379852; 7144053 AB - Protein A (SpA) of Staphylococcus aureus is endowed with the capacity to interact with the H chain variable region (V sub(H)) of human Abs and to target >40% of B lymphocytes. To investigate whether this property represents a virulence factor and to determine the in vivo consequences of the confrontation of SpA with B lymphocytes, we used transgenic mice expressing fully human Abs. We found that administration of soluble SpA reduces B-1a lymphocytes of the peritoneal cavity and marginal zone B lymphocytes of the spleen, resulting in a markedly deficient type 2 humoral response. Single-cell PCR analysis and sequencing of the Ab V sub(H) gene repertoire revealed a significant reduction of V sub(H)3 super(+) marginal zone B cells. Since the two B lymphocyte subsets targeted are involved in innate immune functions, our data suggest that crippling of humoral immunity by S. aureus represents an immune evasion mechanism that may aggravate recurrent infections. JF - Journal of Immunology AU - Viau, Muriel AU - Longo, Nancy S AU - Lipsky, Peter E AU - Zouali, Moncef AD - Institut National de Sante et de Recherche Medicale Unite 430, Immunopathologie Humaine, Paris, France. National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892 Y1 - 2005/12/01/ PY - 2005 DA - 2005 Dec 01 SP - 7719 EP - 7727 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 175 IS - 11 SN - 0022-1767, 0022-1767 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Data processing KW - virulence factors KW - Lymphocytes B KW - protein A KW - Peritoneum KW - Spleen KW - Transgenic mice KW - Immunity (humoral) KW - Polymerase chain reaction KW - Recurrent infection KW - Immune response KW - Staphylococcus aureus KW - Immune response (humoral) KW - Immunoglobulins KW - Variable region KW - V 22350:Immunology KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19379852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Staphylococcal+Protein+A+Deletes+B-1a+and+Marginal+Zone+B+Lymphocytes+Expressing+Human+Immunoglobulins%3A+An+Immune+Evasion+Mechanism&rft.au=Viau%2C+Muriel%3BLongo%2C+Nancy+S%3BLipsky%2C+Peter+E%3BZouali%2C+Moncef&rft.aulast=Viau&rft.aufirst=Muriel&rft.date=2005-12-01&rft.volume=175&rft.issue=11&rft.spage=7719&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Data processing; virulence factors; Lymphocytes B; protein A; Peritoneum; Spleen; Transgenic mice; Immunity (humoral); Polymerase chain reaction; Recurrent infection; Immune response; Immune response (humoral); Variable region; Immunoglobulins; Staphylococcus aureus ER - TY - JOUR T1 - Plant-Based Vaccine: Mice Immunized with Chloroplast-Derived Anthrax Protective Antigen Survive Anthrax Lethal Toxin Challenge AN - 19379141; 7142842 AB - The currently available human vaccine for anthrax, derived from the culture supernatant of Bacillus anthracis, contains the protective antigen (PA) and traces of the lethal and edema factors, which may contribute to adverse side effects associated with this vaccine. Therefore, an effective expression system that can provide a clean, safe, and efficacious vaccine is required. In an effort to produce anthrax vaccine in large quantities and free of extraneous bacterial contaminants, PA was expressed in transgenic tobacco chloroplasts by inserting the pagA gene into the chloroplast genome. Chloroplast integration of the pagA gene was confirmed by PCR and Southern analysis. Mature leaves grown under continuous illumination contained PA as up to 14.2% of the total soluble protein. Cytotoxicity measurements in macrophage lysis assays showed that chloroplast-derived PA was equal in potency to PA produced in B. anthracis. Subcutaneous immunization of mice with partially purified chloroplast-derived or B. anthracis-derived PA with adjuvant yielded immunoglobulin G titers up to 1:320,000, and both groups of mice survived (100%) challenge with lethal doses of toxin. An average yield of about 150 mg of PA per plant should produce 360 million doses of a purified vaccine free of bacterial toxins edema factor and lethal factor from 1 acre of land. Such high expression levels without using fermenters and the immunoprotection offered by the chloroplast-derived PA should facilitate development of a cleaner and safer anthrax vaccine at a lower production cost. These results demonstrate the immunogenic and immunoprotective properties of plant-derived anthrax vaccine antigen. JF - Infection and Immunity AU - Koya, Vijay AU - Moayeri, Mahtab AU - Leppla, Stephen H AU - Daniell, Henry AD - Department of Molecular Biology and Microbiology, University of Central Florida, Biomolecular Science Building 20, Room 336, Orlando, Florida 32816-2364. Microbial Pathogenesis Section, National Institute of Allergy and Infectious Diseases, NIH, Building 30, Room 303, 30 Convent Dr., Bethesda, Maryland 20892-4349 Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 8266 EP - 8274 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 73 IS - 12 SN - 0019-9567, 0019-9567 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Genomes KW - Macrophages KW - Fermenters KW - Plant protection KW - Lethal factor KW - Edema KW - Adjuvants KW - Bacillus anthracis KW - Transgenic plants KW - Integration KW - Tobacco KW - Anthrax KW - Polymerase chain reaction KW - Anthrax lethal toxin KW - protective antigen KW - Leaves KW - Chloroplasts KW - Immunization KW - Cytotoxicity KW - Illumination KW - Immunogenicity KW - Immunoglobulin G KW - Plants KW - Vaccines KW - Contaminants KW - Side effects KW - Lethal dose KW - X 24380:Social Poisons & Drug Abuse KW - F 06905:Vaccines KW - W 30915:Pharmaceuticals & Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19379141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Plant-Based+Vaccine%3A+Mice+Immunized+with+Chloroplast-Derived+Anthrax+Protective+Antigen+Survive+Anthrax+Lethal+Toxin+Challenge&rft.au=Koya%2C+Vijay%3BMoayeri%2C+Mahtab%3BLeppla%2C+Stephen+H%3BDaniell%2C+Henry&rft.aulast=Koya&rft.aufirst=Vijay&rft.date=2005-12-01&rft.volume=73&rft.issue=12&rft.spage=8266&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Genomes; Fermenters; Plant protection; Lethal factor; Edema; Adjuvants; Transgenic plants; Integration; Tobacco; Polymerase chain reaction; Anthrax; Anthrax lethal toxin; protective antigen; Leaves; Chloroplasts; Immunization; Cytotoxicity; Illumination; Immunogenicity; Plants; Immunoglobulin G; Vaccines; Contaminants; Side effects; Lethal dose; Bacillus anthracis ER - TY - JOUR T1 - Drinking Water and Dietary Sources of Nitrate and Nitrite and Risk of Glioma AN - 17481361; 6677734 AB - Dietary nitrite has been associated with increased glioma risk; however, drinking water nitrate has not been extensively evaluated. We conducted a population-based case-control study of adult glioma in Nebraska. Water utility nitrate measurements were linked to residential water source histories. We computed average nitrate exposure over a 20-year period. A food frequency questionnaire was used to assess dietary nitrate and nitrite. Increasing quartiles of the average nitrate level in drinking water were not significantly associated with risk (adjusted odd ratios: 1.4, 1.2, 1.3). Risk was similar among those with both higher and lower intakes of vitamin C, an inhibitor of N-nitroso compound formation. Dietary nitrite intake was not associated with risk. Our study does not support a role for drinking water and dietary sources of nitrate and nitrite in risk of adult glioma. JF - Journal of Occupational and Environmental Medicine AU - Ward, M H AU - Heineman, E F AU - McComb, R D AU - Weisenburger, D D AD - Occupational and Environmental Epidemiology Branch, National Cancer Institute, 6120 Executive Blvd, EPS-8104, Bethesda, MD 20892-7240, USA, wardm@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1260 EP - 1267 VL - 47 IS - 12 SN - 1076-2752, 1076-2752 KW - glioma KW - Water Resources Abstracts; Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts; Pollution Abstracts KW - Nitrate KW - Food KW - Intakes KW - Water quality KW - Dietary intake KW - Utilities KW - Public health KW - Drinking Water KW - History KW - Vitamins KW - Glioma KW - Nitrite KW - Nitrates KW - Ingestion KW - Ascorbic acid KW - Brain tumors KW - Risk KW - Foods KW - N-Nitroso compounds KW - Nitrites KW - USA, Nebraska KW - Drinking water KW - X 24120:Food, additives & contaminants KW - SW 3060:Water treatment and distribution KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17481361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Drinking+Water+and+Dietary+Sources+of+Nitrate+and+Nitrite+and+Risk+of+Glioma&rft.au=Ward%2C+M+H%3BHeineman%2C+E+F%3BMcComb%2C+R+D%3BWeisenburger%2C+D+D&rft.aulast=Ward&rft.aufirst=M&rft.date=2005-12-01&rft.volume=47&rft.issue=12&rft.spage=1260&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2F01.jom.0000184879.67736.ae LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Brain tumors; Nitrate; N-Nitroso compounds; Food; Glioma; Drinking water; Nitrite; Dietary intake; Ascorbic acid; Nitrites; Nitrates; Ingestion; Water quality; Public health; Risk; Foods; Drinking Water; History; Vitamins; Intakes; Utilities; USA, Nebraska DO - http://dx.doi.org/10.1097/01.jom.0000184879.67736.ae ER - TY - JOUR T1 - Metabolism and disposition of juglone in male F344 rats AN - 17474426; 6678353 AB - The metabolism and disposition of super(14)C-labelled juglone in male F344 rats following oral, intravenous and dermal administration were studied. Approximately 40-50% of an oral dose (0.1 to 10 mg kg super(-1)) and less than 20% of the dermal dose (4 mg kg super(-1)) were absorbed within 24 h. Most of the oral dose was excreted in faeces and urine within 24 h and only 1-3% remained in the tissues. High concentrations of juglone-derived radioactivity were found in kidney for all three dosing routes. The accumulation in kidney can be attributed to covalent binding of juglone and/or metabolites to cytosolic protein. Five metabolites were identified in the urine of rats treated with an oral dose: 1,4,5-trihydroxynaphthalene di-glucuronide, 1,4,5-trihydroxynaphthalene mono-glucuronide mono-sulfate, 2-sulfo-2,3-dihydrojuglone, 4,8-dihydroxy-1-tetralone mono-glucuronide and 1,4,5-trihydroxynaphthalene mono-glucuronide. Liver microsomal incubations of juglone in the presence of NAD(P)H and UDP-glucuronic acid gave rise to two 1,4,5-trihydroxynaphthalene mono-glucuronides. JF - Xenobiotica AU - Chen, L-J AU - Lebetkin, E H AU - Burka, L T AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1019 EP - 1034 VL - 35 IS - 10-11 SN - 0049-8254, 0049-8254 KW - Toxicology Abstracts KW - Intravenous administration KW - Skin KW - Urine KW - Kidney KW - Liver KW - Metabolites KW - Disposition KW - Radioactivity KW - Feces KW - Metabolism KW - X 24172:Plants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17474426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenobiotica&rft.atitle=Metabolism+and+disposition+of+juglone+in+male+F344+rats&rft.au=Chen%2C+L-J%3BLebetkin%2C+E+H%3BBurka%2C+L+T&rft.aulast=Chen&rft.aufirst=L-J&rft.date=2005-12-01&rft.volume=35&rft.issue=10-11&rft.spage=1019&rft.isbn=&rft.btitle=&rft.title=Xenobiotica&rft.issn=00498254&rft_id=info:doi/10.1080%2F00498250500356621 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Intravenous administration; Skin; Urine; Liver; Kidney; Disposition; Metabolites; Radioactivity; Feces; Metabolism DO - http://dx.doi.org/10.1080/00498250500356621 ER - TY - JOUR T1 - Resistance and functional training reduces knee extensor position fluctuations in functionally limited older adults AN - 17469256; 6654941 AB - The purpose of this study was to determine the effect of task-specificity on knee extensor steadiness adaptations in functionally limited older adults. Twenty-four functionally limited older adults (74.6 plus or minus 7.6 years: 22 women, 2 men) completed a 10-week control period followed by 10 weeks (2 days/week) of resistance (RT), functional (FT) (practicing everyday tasks, i.e., chair rises) or functional + resistance (FRT) training, which featured both shortening and lengthening movements. During testing, subjects performed a steady isometric [10, 25, 50% of maximal voluntary contraction (MVC)] and shortening/lengthening (5, 30, 65% of MVC) knee extensor contractions. There were no steadiness (isometric, shortening or lengthening contractions) changes in the control period and no adaptations in isometric steadiness due to training. RT induced a 37% reduction in shortening fluctuations at 5% of MVC and 35% reduction in lengthening fluctuations at both 30% and 65% of MVC. FRT induced a 60% reduction in shortening fluctuations at 30% of MVC. No adaptations in dynamic steadiness were observed in the FT group. Further analysis indicated that those who were the least steady at baseline showed the greatest training effects during isometric (RT: R super(2)=0.25, FRT: R super(2)=0.49, FT: R super(2)=0.38), shortening (RT: R super(2)=0.36, FRT: R super(2)=0.36, FT: R super(2)=0.35) and lengthening (RT: r super(2)=0.29, FRT: r super(2)=0.44) contractions. In conclusion, steadiness improvements in groups performing resistance exercise, without a concomitant improvement in the FT group, supports a role for task-specificity in explaining steadiness adaptations, particularly for unsteady older adults. JF - European Journal of Applied Physiology AU - Manini, T M AU - Clark, B C AU - Tracy, B L AU - Burke, J AU - Ploutz-Snyder, L AD - Musculoskeletal Research Laboratory, Syracuse University, Syracuse, NY, USA, maninit@mail.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 436 EP - 446 PB - Springer-Verlag (New York), P.O. Box 2485 Secaucus NJ 07096-2485 USA, [mailto:orders@springer-ny.com], [URL:http://www.springer-ny.com/] VL - 95 IS - 5-6 SN - 1439-6319, 1439-6319 KW - Physical Education Index KW - Exercise physiology KW - Men KW - Analysis KW - Women KW - Gerontology KW - Knees KW - Isometrics KW - Adults KW - Resistance exercise KW - Movement KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17469256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Applied+Physiology&rft.atitle=Resistance+and+functional+training+reduces+knee+extensor+position+fluctuations+in+functionally+limited+older+adults&rft.au=Manini%2C+T+M%3BClark%2C+B+C%3BTracy%2C+B+L%3BBurke%2C+J%3BPloutz-Snyder%2C+L&rft.aulast=Manini&rft.aufirst=T&rft.date=2005-12-01&rft.volume=95&rft.issue=5-6&rft.spage=436&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Applied+Physiology&rft.issn=14396319&rft_id=info:doi/10.1007%2Fs00421-005-0048-x LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Exercise physiology; Men; Analysis; Women; Knees; Gerontology; Isometrics; Resistance exercise; Adults; Movement DO - http://dx.doi.org/10.1007/s00421-005-0048-x ER - TY - JOUR T1 - ORIGINAL ARTICLE: Selective inhibition by rottlerin of macropinocytosis in monocyte-derived dendritic cells AN - 17447082; 6550918 AB - We present here the analysis of fluid-phase endocytosis (FPE) in human blood monocytes and monocyte-derived dendritic cells (MDDC) facilitated by our serendipitous identification of rottlerin as an efficient inhibitor of dendritic cell FPE (IC sub(50) of 0.4 mu M). Rottlerin was found to be an excellent tool for FPE analysis: rapid-acting, irreversible and selective for FPE (as opposed to receptor-mediated endocytosis) at concentrations of 3 mu M and below. The inhibitory effect was not due to toxicity or visible change in membrane ruffles, but affects on cytoskeletal reorganization were evident in MDDC treated with relevant rottlerin concentrations during adhesion. A marked increase in FPE was observed in 1 hr interleukin (IL)-4 and granulocyte macrophage-colony stimulating factor (GM-CSF)-stimulated monocytes. Moreover, rottlerin inhibited the augmented FPE of 1-day cytokine treated monocytes and their augmented ability to induce T cell proliferative responses to tetanus toxoid. We conclude that rottlerin is a useful tool for investigating FPE and its functional importance. JF - Immunology AU - Sarkar, Kakali AU - Kruhlak, Michael J AU - Erlandsen, Stanley L AU - Shaw, Stephen AD - Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, sshaw@nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 513 EP - 524 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 116 IS - 4 SN - 0019-2805, 0019-2805 KW - rottlerin KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Interleukins KW - Granulocyte-macrophage colony-stimulating factor KW - Toxoids KW - Toxicity KW - Tetanus KW - Cytoskeleton KW - Blood KW - Endocytosis KW - Dendritic cells KW - Pinocytosis KW - Lymphocytes T KW - Vaccines KW - Monocytes KW - J 02350:Immunology KW - F 06622:Dendritic cells (plasmacytoid, monocyte-derived, Langerhans) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17447082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunology&rft.atitle=ORIGINAL+ARTICLE%3A+Selective+inhibition+by+rottlerin+of+macropinocytosis+in+monocyte-derived+dendritic+cells&rft.au=Sarkar%2C+Kakali%3BKruhlak%2C+Michael+J%3BErlandsen%2C+Stanley+L%3BShaw%2C+Stephen&rft.aulast=Sarkar&rft.aufirst=Kakali&rft.date=2005-12-01&rft.volume=116&rft.issue=4&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=Immunology&rft.issn=00192805&rft_id=info:doi/10.1111%2Fj.1365-2567.2005.02253.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - SuppNotes - Figures, 10; references, 46. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Granulocyte-macrophage colony-stimulating factor; Interleukins; Toxicity; Toxoids; Tetanus; Cytoskeleton; Dendritic cells; Endocytosis; Blood; Pinocytosis; Lymphocytes T; Monocytes; Vaccines DO - http://dx.doi.org/10.1111/j.1365-2567.2005.02253.x ER - TY - JOUR T1 - Bacterial metal detectors AN - 17438677; 6555897 AB - Gram negative bacteria can detect environmental iron using outer membrane transporters (OMTs), and then regulate certain transport genes to take advantage of a readily available iron source. This process begins with an iron complex being bound by an OMT, and results in a signal being sent across the outer membrane, the periplasmic space, and the inner membrane, to a sigma factor that interacts with RNA polymerase and initiates transcription of relevant genes. Many of the interactions contributing to signalling have been observed by genetic and biochemical studies, but structural studies, which potentially show these interactions in molecular detail, have been limited. In this issue, Garcia-Herrero and Vogel describe an NMR structure of the periplasmic domain of an OMT, which had not been seen in previous X-ray crystal structures. This domain transmits the 'iron availability' signal to the next protein in the signal transduction cascade, which sits in the inner membrane and extends into the periplasm. The new structure extends our knowledge of transporter architecture and suggests how signalling may occur across the outer membrane. JF - Molecular Microbiology AU - Buchanan, Susan K AD - Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA, skbuchan@helix.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1205 EP - 1209 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 58 IS - 5 SN - 0950-382X, 0950-382X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Bacteria KW - Metals KW - Periplasmic space KW - Heavy metals KW - Outer membranes KW - Transcription KW - DNA-directed RNA polymerase KW - Ionizing radiation KW - Gram-negative bacteria KW - Inner membranes KW - Crystal structure KW - N.M.R. KW - Sigma factor KW - Iron KW - periplasm KW - Signal transduction KW - J 02721:Cell cycle, morphology and motility KW - A 01450:Environmental Pollution & Waste Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17438677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Bacterial+metal+detectors&rft.au=Buchanan%2C+Susan+K&rft.aulast=Buchanan&rft.aufirst=Susan&rft.date=2005-12-01&rft.volume=58&rft.issue=5&rft.spage=1205&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2005.04904.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - SuppNotes - Figures, 3; references, 14. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Metals; Heavy metals; Periplasmic space; Outer membranes; Transcription; DNA-directed RNA polymerase; Inner membranes; Gram-negative bacteria; Ionizing radiation; Crystal structure; N.M.R.; Sigma factor; periplasm; Iron; Signal transduction; Bacteria DO - http://dx.doi.org/10.1111/j.1365-2958.2005.04904.x ER - TY - JOUR T1 - Differential cis-regulation of human versus mouse TERT gene expression in vivo: Identification of a human-specific repressive element AN - 17438513; 6578684 AB - In vivo expression of human telomerase is significantly different from that of mouse telomerase. To assess the basis for this difference, a bacterial artificial chromosome clone containing the entire hTERT (human telomerase reverse transcriptase) gene was introduced in mice. In these transgenic mice, expression of the hTERT transgene was similar to that of endogenous hTERT in humans, rather than endogenous mTERT (mouse telomerase reverse transcriptase). In tissues and cells showing a striking difference in expression levels between hTERT in humans and mTERT in mice (i.e., liver, kidney, lung, uterus, and fibroblasts), expression of the hTERT transgene in transgenic mice was repressed, mimicking hTERT in humans. The transcriptional activity of the hTERT promoter was much lower than that of the mTERT promoter in mouse embryonic fibroblasts or human fibroblasts. Mutational analysis of the hTERT and mTERT promoters revealed that a nonconserved GC-box within the hTERT promoter was responsible for the human-specific repression. These results reveal that a difference in cis-regulation of transcription, rather than transacting transcription factors, is critical to species differences in tissue-specific TERT expression. Our data also suggest that the GC-box-mediated, human-specific mechanism for TERT repression is impaired in human cancers. This study represents a detailed characterization of the functional difference in a gene promoter of mice versus humans and provides not only important insight into species-specific regulation of telomerase and telomeres but also an experimental basis for generating mice humanized for telomerase enzyme and its pattern of expression. JF - Proceedings of the National Academy of Sciences, USA AU - Horikawa, Izumi AU - Chiang, YJeffrey AU - Patterson, Tricia AU - Feigenbaum, Lionel AU - Leem, Sun-Hee AU - Michishita, Eriko AU - Larionov, Vladimir AU - Hodes, Richard J AU - Barrett, JCarl AD - Laboratory of Biosystems and Cancer and Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 18437 EP - 18442 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 102 IS - 51 SN - 0027-8424, 0027-8424 KW - mice KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Oncogenes & Growth Factors Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Mimicry KW - Uterus KW - Data processing KW - Transgenes KW - Enzymes KW - telomerase reverse transcriptase KW - Transgenic mice KW - Cancer KW - Fibroblasts KW - Gene expression KW - Bacterial artificial chromosomes KW - Telomeres KW - Promoters KW - Lung KW - Transcription factors KW - Embryo fibroblasts KW - Liver KW - Kidney KW - Embryos KW - Telomerase reverse transcriptase KW - J 02310:Genetics & Taxonomy KW - B 26248:DNA repair KW - N 14045:Transcriptional regulation KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17438513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Differential+cis-regulation+of+human+versus+mouse+TERT+gene+expression+in+vivo%3A+Identification+of+a+human-specific+repressive+element&rft.au=Horikawa%2C+Izumi%3BChiang%2C+YJeffrey%3BPatterson%2C+Tricia%3BFeigenbaum%2C+Lionel%3BLeem%2C+Sun-Hee%3BMichishita%2C+Eriko%3BLarionov%2C+Vladimir%3BHodes%2C+Richard+J%3BBarrett%2C+JCarl&rft.aulast=Horikawa&rft.aufirst=Izumi&rft.date=2005-12-01&rft.volume=102&rft.issue=51&rft.spage=18437&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-04-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Mimicry; Uterus; Data processing; Transgenes; Enzymes; telomerase reverse transcriptase; Transgenic mice; Cancer; Fibroblasts; Bacterial artificial chromosomes; Gene expression; Promoters; Telomeres; Lung; Transcription factors; Embryo fibroblasts; Kidney; Liver; Embryos; Telomerase reverse transcriptase ER - TY - JOUR T1 - Cocaine-induced CREB phosphorylation in nucleus accumbens of cocaine-sensitized rats is enabled by enhanced activation of extracellular signal-related kinase, but not protein kinase A AN - 17435276; 6552992 AB - Repeated cocaine administration to rats outside their home cages sensitizes the behavioral effects of the drug, and enhances induction of the immediate early gene product Fos in nucleus accumbens. We hypothesized that the same treatment regimen would also enhance cocaine-induced activation of intracellular signaling kinases that phosphorylate cyclic AMP-regulated element-binding protein (CREB), an important mediator of c-fos transcription. Phosphorylation levels of extracellular signal-regulated kinase (ERK)-mitogen-activated protein kinase (MAPK), calcium-calmodulin kinases (CaMKs) II and IV, and CREB were used to assess endogenous functional activity of these signaling molecules in rats behaviorally sensitized outside their home cages. Protein kinase A (PKA)-specific phosphorylation of Ser845 in the alpha -amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor subunit GluR1 was used to assess endogenous functional activity of PKA. Using western blots and immunohistochemistry, we detected cocaine-induced CREB phosphorylation after repeated cocaine administration, but not after repeated saline administration. Using western blots and MAPK activity assays, we found that cocaine-induced phosphorylation and activation of ERK, but not of CaMKs II or IV or GluR1, was augmented in nucleus accumbens of cocaine-sensitized rats. Unilateral infusions of the MAPK kinase inhibitor U0126 into nucleus accumbens attenuated cocaine-induced ERK and CREB phosphorylation in cocaine-sensitized rats. In contrast, unilateral infusions of the PKA inhibitor Rp-isomer of adenosine-3',5'-cyclicmonophosphorothioate (Rp-cAMPs) did not affect cocaine-induced CREB phosphorylation. Therefore, enhanced activation of ERK, but not PKA, enables and mediates cocaine-induced CREB phosphorylation in nucleus accumbens of rats that are sensitized by repeated cocaine administration outside their home cages. JF - Journal of Neurochemistry AU - Mattson, Brandi J AU - Bossert, Jennifer M AU - Simmons, Danielle E AU - Nozaki, Naohito AU - Nagarkar, Deepti AU - Kreuter, Justin D AU - Hope, Bruce T AD - Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA, bhope@intra.nida.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1481 EP - 1494 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 95 IS - 5 SN - 0022-3042, 0022-3042 KW - rats KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Intracellular signalling KW - Western blotting KW - Nucleus accumbens KW - MAP kinase KW - Protein kinase A KW - Transcription KW - c-Fos protein KW - Drug abuse KW - alpha -Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors KW - Glutamic acid receptors (ionotropic) KW - Fos protein KW - Extracellular signal-regulated kinase KW - Phosphorylation KW - alpha -Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid KW - Cocaine KW - Ca super(2+)/calmodulin-dependent protein kinase II KW - Immunohistochemistry KW - Cyclic AMP response element-binding protein KW - Signal transduction KW - N3 11106:Neurobiology of drug abuse KW - X 24180:Social poisons & drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17435276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurochemistry&rft.atitle=Cocaine-induced+CREB+phosphorylation+in+nucleus+accumbens+of+cocaine-sensitized+rats+is+enabled+by+enhanced+activation+of+extracellular+signal-related+kinase%2C+but+not+protein+kinase+A&rft.au=Mattson%2C+Brandi+J%3BBossert%2C+Jennifer+M%3BSimmons%2C+Danielle+E%3BNozaki%2C+Naohito%3BNagarkar%2C+Deepti%3BKreuter%2C+Justin+D%3BHope%2C+Bruce+T&rft.aulast=Mattson&rft.aufirst=Brandi&rft.date=2005-12-01&rft.volume=95&rft.issue=5&rft.spage=1481&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurochemistry&rft.issn=00223042&rft_id=info:doi/10.1111%2Fj.1471-4159.2005.03500.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - SuppNotes - Figures, 9; references, 65. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Nucleus accumbens; Western blotting; Intracellular signalling; Protein kinase A; MAP kinase; Transcription; c-Fos protein; Drug abuse; alpha -Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors; Glutamic acid receptors (ionotropic); Fos protein; Extracellular signal-regulated kinase; Phosphorylation; alpha -Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; Cocaine; Immunohistochemistry; Ca super(2+)/calmodulin-dependent protein kinase II; Signal transduction; Cyclic AMP response element-binding protein DO - http://dx.doi.org/10.1111/j.1471-4159.2005.03500.x ER - TY - JOUR T1 - Crystal structures of T cell receptor beta chains related to rheumatoid arthritis AN - 17429726; 6581427 AB - The crystal structures of the V beta 17 super(+) beta chains of two human T cell receptors (TCRs), originally derived from the synovial fluid (SF4) and tissue (C5-1) of a patient with rheumatoid arthritis (RA), have been determined in native (SF4) and mutant (C5-1 sub(F104 arrow right Y/C187 arrow right S)) forms, respectively. These TCR beta chains form homo-dimers in solution and in crystals. Structural comparison reveals that the main-chain conformations in the CDR regions of the C5-1 and SF4 V beta 17 closely resemble those of a V beta 17 JM22 in a bound form; however, the CDR3 region shows different conformations among these three V beta 17 structures. At the side-chain level, conformational differences were observed at the CDR2 regions between our two ligand-free forms and the bound JM22 form. Other significant differences were observed at the V beta regions 8-12, 40-44, and 82-88 between C5-1/SF4 and JM22 V beta 17, implying that there is considerable variability in the structures of very similar beta chains. Structural alignments also reveal a considerable variation in the V beta -C beta associations, and this may affect ligand recognition. The crystal structures also provide insights into the structure basis of T cell recognition of Mycoplasma arthritidis mitogen (MAM), a superantigen that may be implicated in the development of human RA. Structural comparisons of the V beta domains of known TCR structures indicate that there are significant similarities among V beta regions that are MAM-reactive, whereas there appear to be significant structural differences among those V beta regions that lack MAM-reactivity. It further reveals that CDR2 and framework region (FR) 3 are likely to account for the binding of TCR to MAM. JF - Protein Science AU - Li, Hongmin AU - Van Vranken, Sandra AU - Zhao, Yiwei AU - Li, Zhong AU - Guo, Yi AU - Eisele, Leslie AU - Li, Yixin AD - Wadsworth Center, New York State Department of Health, and Department of Biomedical Sciences, School of Public Health, University at Albany, State University of New York, Empire State Plaza, Albany, New York 12201-0509, USA. Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 3025 EP - 3038 PB - Cold Spring Harbor Laboratory Press, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 14 IS - 12 SN - 0961-8368, 0961-8368 KW - Microbiology Abstracts B: Bacteriology KW - complementarity-determining region 3 KW - Rheumatoid arthritis KW - Superantigens KW - Synovial fluid KW - double prime T-cell receptor KW - Mycoplasma arthritidis KW - Crystal structure KW - Lymphocytes T KW - Proteins KW - Mitogens KW - Crystals KW - J 02727:Amino acids, peptides and proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17429726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Science&rft.atitle=Crystal+structures+of+T+cell+receptor+beta+chains+related+to+rheumatoid+arthritis&rft.au=Li%2C+Hongmin%3BVan+Vranken%2C+Sandra%3BZhao%2C+Yiwei%3BLi%2C+Zhong%3BGuo%2C+Yi%3BEisele%2C+Leslie%3BLi%2C+Yixin&rft.aulast=Li&rft.aufirst=Hongmin&rft.date=2005-12-01&rft.volume=14&rft.issue=12&rft.spage=3025&rft.isbn=&rft.btitle=&rft.title=Protein+Science&rft.issn=09618368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-06-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - complementarity-determining region 3; Superantigens; Rheumatoid arthritis; Synovial fluid; double prime T-cell receptor; Lymphocytes T; Crystal structure; Mitogens; Proteins; Crystals; Mycoplasma arthritidis ER - TY - JOUR T1 - TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis AN - 17428442; 6577859 AB - To investigate the role of Toll-like receptor (TLR)9 in the immune response to mycobacteria as well as its cooperation with TLR2, a receptor known to be triggered by several major mycobacterial ligands, we analyzed the resistance of TLR9 super(-/-) as well as TLR2/9 double knockout mice to aerosol infection with Mycobacterium tuberculosis. Infected TLR9 super(-/-) but not TLR2 super(-/-) mice displayed defective mycobacteria-induced interleukin (IL)-12p40 and interferon (IFN)- gamma responses in vivo, but in common with TLR2 super(-/-) animals, the TLR9 super(-/-) mice exhibited only minor reductions in acute resistance to low dose pathogen challenge. When compared with either of the single TLR-deficient animals, TLR2/9 super(-/-) mice displayed markedly enhanced susceptibility to infection in association with combined defects in proinflammatory cytokine production in vitro, IFN- gamma recall responses ex vivo, and altered pulmonary pathology. Cooperation between TLR9 and TLR2 was also evident at the level of the in vitro response to live M. tuberculosis, where dendritic cells and macrophages from TLR2/9 super(-/-) mice exhibited a greater defect in IL-12 response than the equivalent cell populations from single TLR9-deficient animals. These findings reveal a previously unappreciated role for TLR9 in the host response to M. tuberculosis and illustrate TLR collaboration in host resistance to a major human pathogen. JF - Journal of Experimental Medicine AU - Bafica, Andre AU - Scanga, Charles A AU - Feng, Carl G AU - Leifer, Cynthia AU - Cheever, Allen AU - Sher, Alan AD - Immunobiology Section, Laboratory of Parasitic Diseases. Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. Laboratorio de Imunorregulacao e Microbiologia, Centro de Pesquisas Goncalo Moniz, FIOCRUZ, Bahia 40296-710, Brazil. Biomedical Research Institute, Rockville, MD 20852 Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 1715 EP - 1724 PB - Rockefeller University Press, 1114 First Avenue New York NY 10021-8325 USA, [mailto:Bruce.Lyons@rockefeller.edu], [URL:http://www.rockefeller.edu/rupress] VL - 202 IS - 12 SN - 0022-1007, 0022-1007 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - gamma -Interferon KW - Aerosols KW - TLR9 protein KW - TLR2 protein KW - Pathogens KW - Infection KW - Inflammation KW - Interleukin 12 KW - Dendritic cells KW - Tuberculosis KW - Toll-like receptors KW - Mycobacterium tuberculosis KW - J 02833:Immune response and immune mechanisms KW - F 06106:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17428442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Medicine&rft.atitle=TLR9+regulates+Th1+responses+and+cooperates+with+TLR2+in+mediating+optimal+resistance+to+Mycobacterium+tuberculosis&rft.au=Bafica%2C+Andre%3BScanga%2C+Charles+A%3BFeng%2C+Carl+G%3BLeifer%2C+Cynthia%3BCheever%2C+Allen%3BSher%2C+Alan&rft.aulast=Bafica&rft.aufirst=Andre&rft.date=2005-12-01&rft.volume=202&rft.issue=12&rft.spage=1715&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Medicine&rft.issn=00221007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Dendritic cells; Interleukin 12; gamma -Interferon; Aerosols; TLR9 protein; TLR2 protein; Tuberculosis; Pathogens; Infection; Toll-like receptors; Inflammation; Mycobacterium tuberculosis ER - TY - JOUR T1 - The Genome of Bacteriophage K1F, a T7-Like Phage That Has Acquired the Ability To Replicate on K1 Strains of Escherichia coli AN - 17424341; 6577046 AB - Bacteriophage K1F specifically infects Escherichia coli strains that produce the K1 polysaccharide capsule. Like several other K1 capsule-specific phages, K1F encodes an endo-neuraminidase (endosialidase) that is part of the tail structure which allows the phage to recognize and degrade the polysaccharide capsule. The complete nucleotide sequence of the K1F genome reveals that it is closely related to bacteriophage T7 in both genome organization and sequence similarity. The most striking difference between the two phages is that K1F encodes the endosialidase in the analogous position to the T7 tail fiber gene. This is in contrast with bacteriophage K1-5, another K1-specific phage, which encodes a very similar endosialidase which is part of a tail gene "module" at the end of the phage genome. It appears that diverse phages have acquired endosialidase genes by horizontal gene transfer and that these genes or gene products have adapted to different genome and virion architectures. JF - Journal of Bacteriology AU - Scholl, Dean AU - Merril, Carl AD - National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 8499 EP - 8503 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 187 IS - 24 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Virology & AIDS Abstracts KW - phage K1F KW - Phages KW - Virions KW - Endo- alpha -sialidase KW - Genomes KW - Tails KW - Nucleotide sequence KW - Polysaccharides KW - Genetic relationship KW - Gene transfer KW - Escherichia coli KW - Tail fibers KW - Genetic structure KW - G 07312:Phages KW - J 02750:Phage-host interactions KW - V 22070:Phage-host interactions including lysogeny & transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17424341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=The+Genome+of+Bacteriophage+K1F%2C+a+T7-Like+Phage+That+Has+Acquired+the+Ability+To+Replicate+on+K1+Strains+of+Escherichia+coli&rft.au=Scholl%2C+Dean%3BMerril%2C+Carl&rft.aulast=Scholl&rft.aufirst=Dean&rft.date=2005-12-01&rft.volume=187&rft.issue=24&rft.spage=8499&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Endo- alpha -sialidase; Virions; Genetic relationship; Phages; Tails; Gene transfer; Nucleotide sequence; Tail fibers; Polysaccharides; Genetic structure; phage K1F; Escherichia coli ER - TY - JOUR T1 - A detailed behavioral analysis of the acute motor effects of caffeine in the rat: involvement of adenosine A sub(1) and A sub(2A) receptors AN - 17205255; 6889206 AB - Rationale: There is no consensus on the contribution of adenosine A sub(1) and A sub(2A) receptor blockade to motor-activating effects of caffeine. Objective: Our aim was to use a detailed and continuous observational method to compare the motor effects induced by caffeine with those induced by selective A sub(1) and A sub(2A) receptor antagonists. Methods: The behavioral repertoire induced by systemic administration of caffeine (3, 10, and 30 mg/kg), A sub(1) receptor antagonist 8-cyclopentyl-1,3-dimethylxanthine (CPT; 1.2, 4.8 and 7.2 mg/kg), and A sub(2A) receptor antagonist 3-(3-hydroxypropyl)-8-(m-methoxystyryl)-7-methyl-1-propargylxan thine phosphate disodium salt (MSX-3; 1, 3, and 10 mg/kg) was analyzed. The effects of pretreatment with the selective A sub(1) receptor agonist N super(6)-cyclopentyladenosine (CPA; 0.1 mg/g) and the selective A sub(2A) receptor agonist 2-p-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxyamidoad enosine (CGS 21680; 0.2 mg/kg) on the pattern of motor activation induced by caffeine, CPT, or MSX-3 were also examined. Results: The pattern of behavioral activation induced by caffeine was better mimicked by CPT than by MSX-3. Coadministration of CPT and MSX-3 gave different results depending on the dose and the type of behavioral response. CPA was more effective at decreasing the activating effects of caffeine and CPT than those of CGS 21680. On the other hand, CGS 21680 was more effective at decreasing the activating effects of MSX-3 than those of caffeine or CPT. Factor analysis revealed a complex three-dimensional behavioral profile for caffeine that was similar to the profile for CPT and was different from the profile for MSX-3. Conclusions: The results indicate a predominant role for A sub(1) receptors in the motor-activating effects of acutely administered caffeine. JF - Psychopharmacology AU - Antoniou, Katerina AU - Papadopoulou-Daifoti, Zeta AU - Hyphantis, Thomas AU - Papathanasiou, Georgia AU - Bekris, Efstathios AU - Marselos, Marios AU - Panlilio, Leigh AU - Mueller, Christa E AU - Goldberg, Steven R AU - Ferre, Sergi AD - Behavioral Neuroscience Branch, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, MD, 21224, USA, sferre@intra.nida.nih.gov Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 154 EP - 162 PB - Springer-Verlag (Berlin), Heidelberger Platz 3 Berlin 14197 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 183 IS - 2 SN - 0033-3158, 0033-3158 KW - Factor analysis KW - rats KW - CSA Neurosciences Abstracts; Animal Behavior Abstracts; Toxicology Abstracts KW - Motor activity KW - Caffeine KW - Adenosine A1 receptors KW - Adenosine A2A receptors KW - Y 25777:Mammals (excluding primates) KW - X 24180:Social poisons & drug abuse KW - N3 11139:Toxicological and psychoactive drug correlates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17205255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=A+detailed+behavioral+analysis+of+the+acute+motor+effects+of+caffeine+in+the+rat%3A+involvement+of+adenosine+A+sub%281%29+and+A+sub%282A%29+receptors&rft.au=Antoniou%2C+Katerina%3BPapadopoulou-Daifoti%2C+Zeta%3BHyphantis%2C+Thomas%3BPapathanasiou%2C+Georgia%3BBekris%2C+Efstathios%3BMarselos%2C+Marios%3BPanlilio%2C+Leigh%3BMueller%2C+Christa+E%3BGoldberg%2C+Steven+R%3BFerre%2C+Sergi&rft.aulast=Antoniou&rft.aufirst=Katerina&rft.date=2005-12-01&rft.volume=183&rft.issue=2&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/10.1007%2Fs00213-005-0173-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Motor activity; Adenosine A1 receptors; Caffeine; Adenosine A2A receptors DO - http://dx.doi.org/10.1007/s00213-005-0173-6 ER - TY - JOUR T1 - Characterization of Both MTBE and BTEX in the Ambient Air of Night Markets in Southern Taiwan AN - 17135377; 6756488 AB - To characterize concentrations of volatile organic compounds (VOCs) at the night markets in southern Taiwan, four representative night markets and one background location were selected for this study. The VOCs measured included methyl tertiary-butyl ether (MTBE) and BTEX (the acronym for benzene, toluene, ethylbenzene, and xylene). The results indicated that the measured concentrations of MTBE and BTEX were typically on the order of one to two times higher at night market level than at the background site. It is clear that the night market activities in all sampling sites affected the distribution of MTBE and BTEX. During non-night market activities, the average MTBE-BTEX ratios of Liu-Ho, Rui-Guang, Ping-Tung and Chao-Zhou were (13.9: 2.2: 10.1: 1.0: 6.1), (4.9: 3.8: 13.7: 1.0: 7.9), (10.3: 1.7: 8.2: 1.0: 3.9) and (87.4: 10: 46: 1.0: 9.1), respectively. However, during the night market activities, the average MTBE-BTEX ratios shifted to (27.4: 1.9: 21.9: 1.0: 4.3), (23.1: 3.9: 16.5: 1.0: 3.2), (38.6: 6.8: 30.1: 1.0: 14.9), and (38.6: 7.8: 24.3: 1.0: 5.1), respectively. JF - Aerosol and Air Quality Resarch AU - Hsieh, Lien-Te AU - Yang, His-Hsieh AU - Chen, Ho-Wen AD - Department of Environmental Engineering and Science, National Pingtung University of Science and Technology, Nei Pu 912, Ping Tung, Taiwan, Lthsieh@.mail.npust.edu.tw Y1 - 2005/12// PY - 2005 DA - Dec 2005 SP - 154 EP - 170 VL - 5 IS - 2 SN - 1680-8584, 1680-8584 KW - Meteorological & Geoastrophysical Abstracts; Pollution Abstracts KW - Taiwan KW - Aerosols KW - Atmospheric pollution KW - MTBE KW - Toluene KW - Acronyms KW - Air quality KW - Benzene KW - Xylene KW - Chemical speciation KW - Volatile organic compounds KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17135377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aerosol+and+Air+Quality+Resarch&rft.atitle=Characterization+of+Both+MTBE+and+BTEX+in+the+Ambient+Air+of+Night+Markets+in+Southern+Taiwan&rft.au=Hsieh%2C+Lien-Te%3BYang%2C+His-Hsieh%3BChen%2C+Ho-Wen&rft.aulast=Hsieh&rft.aufirst=Lien-Te&rft.date=2005-12-01&rft.volume=5&rft.issue=2&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Aerosol+and+Air+Quality+Resarch&rft.issn=16808584&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Atmospheric pollution; Acronyms; Air quality; Aerosols; Xylene; Toluene; Chemical speciation; MTBE; Benzene; Volatile organic compounds; Taiwan ER - TY - JOUR T1 - Post insult enriched housing improves the 8-arm radial maze performance but not the Morris water maze task in ventral subicular lesioned rats. AN - 68881836; 16324686 AB - The present study attempted to evaluate the efficacy of enriched housing conditions in promoting behavioral recovery following subicular lesion. Rats with bilateral ibotenic acid lesions of ventral subiculum were exposed to either enriched housing conditions or standard housing for 6 h daily for 10 days. The performance of the lesioned rats reared in standard housing conditions was severely impaired in both 8-arm radial maze and water maze tasks. Lesioned rats exposed to enriched housing showed behavioral recovery in the 8-arm radial maze but not in the water maze. Our study suggests the possibility that recovery may be based on the functional demand of spatial tasks and may require more appropriate environmental stimulation. JF - Brain research AU - Bindu, B AU - Rekha, J AU - Kutty, Bindu M AD - Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences (NIMHANS), P.O. Box No.2900, Hosur Road, Bangalore-560 029, India. Y1 - 2005/11/30/ PY - 2005 DA - 2005 Nov 30 SP - 121 EP - 131 VL - 1063 IS - 2 SN - 0006-8993, 0006-8993 KW - Excitatory Amino Acid Agonists KW - 0 KW - Ibotenic Acid KW - 2552-55-8 KW - Index Medicus KW - Rats KW - Animals KW - Housing, Animal KW - Rats, Wistar KW - Recovery of Function -- physiology KW - Ibotenic Acid -- toxicity KW - Excitatory Amino Acid Agonists -- toxicity KW - Male KW - Environment Design KW - Maze Learning -- physiology KW - Nerve Degeneration -- physiopathology KW - Nerve Degeneration -- pathology KW - Nerve Degeneration -- chemically induced KW - Hippocampus -- physiopathology KW - Behavior, Animal -- physiology KW - Hippocampus -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68881836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Post+insult+enriched+housing+improves+the+8-arm+radial+maze+performance+but+not+the+Morris+water+maze+task+in+ventral+subicular+lesioned+rats.&rft.au=Bindu%2C+B%3BRekha%2C+J%3BKutty%2C+Bindu+M&rft.aulast=Bindu&rft.aufirst=B&rft.date=2005-11-30&rft.volume=1063&rft.issue=2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-15 N1 - Date created - 2005-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A quantitative slot blot assay for host cell protein impurities in recombinant proteins expressed in E. coli AN - 17451757; 6637944 AB - Residual host cell protein impurities in recombinant proteins intended for human use must be accurately quantified to help establish their safety. We describe a novel means of host cell protein quantitation, in which a slot blot system was employed together with scanning laser densitometry to allow picogram level sensitivity in detection of residual host cell proteins in unpurified fermentation products and final purified bulk samples. Two allelic forms of merozoite surface protein 1, a promising malaria vaccine candidate antigen currently undergoing evaluation in clinical trials, were expressed in E. coli as clinical grade proteins, refolded, and carried through several chromatographic purification steps. Several lots of these proteins were analyzed with this generic quantitative assay that uses rat polyclonal antibodies generated against soluble and insoluble E. coli proteins. The assay had a detection range of 6.1-1562 ng/mL, with a detection limit of 6.1 ng/mL, comparable to reported ELISA-based methods. This assay proved simple yet very sensitive and accurate, giving highly reproducible results. Thus it is suitable for evaluating host cell protein levels in clinical grade recombinant proteins expressed in E. coli. electrophoresis JF - Journal of Immunological Methods AU - Zhu, D AU - Saul, A J AU - Miles, A P AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA, dzhu@niaid.nih.gov Y1 - 2005/11/30/ PY - 2005 DA - 2005 Nov 30 SP - 40 EP - 50 PB - Elsevier B.V. VL - 306 IS - 1-2 SN - 0022-1759, 0022-1759 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Immunology Abstracts KW - Enzyme-linked immunosorbent assay KW - Electrophoresis KW - Fermentation KW - Impurities KW - Merozoite surface protein 1 KW - Malaria KW - protein purification KW - Clinical trials KW - Antibodies KW - Escherichia coli KW - Vaccines KW - Quantitation KW - Densitometry KW - K 03410:Animal Diseases KW - W 30965:Miscellaneous, Reviews KW - W3 33250:Methods: Others KW - F 06708:Other methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17451757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=A+quantitative+slot+blot+assay+for+host+cell+protein+impurities+in+recombinant+proteins+expressed+in+E.+coli&rft.au=Zhu%2C+D%3BSaul%2C+A+J%3BMiles%2C+A+P&rft.aulast=Zhu&rft.aufirst=D&rft.date=2005-11-30&rft.volume=306&rft.issue=1-2&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2005.07.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-03-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Antibodies; Electrophoresis; Fermentation; Impurities; Malaria; Merozoite surface protein 1; Vaccines; protein purification; Quantitation; Clinical trials; Densitometry; Escherichia coli DO - http://dx.doi.org/10.1016/j.jim.2005.07.021 ER - TY - JOUR T1 - Knockout of caspase-like gene, YCA1, abrogates apoptosis and elevates oxidized proteins in Saccharomyces cerevisiae. AN - 68845691; 16301538 AB - In our previous study, we established that inhibition of apoptosis by the general caspase inhibitor is associated with an increase in the level of oxidized proteins in a multicellular eukaryotic system. To gain further insight into a potential link between oxidative stress and apoptosis, we carried out studies with Saccharomyces cerevisiae, which contains a gene (YCA1) that encodes synthesis of metacaspase, a homologue of the mammalian caspase, and is known to play a crucial role in the regulation of yeast apoptosis. We show that upon exposure to H(2)O(2), the accumulation of protein carbonyls is much greater in a Delta yca1 strain lacking the YCA1 gene than in the wild type and that apoptosis was abrogated in the Delta yca1 strain, whereas wild type underwent apoptosis as measured by externalization of phosphatidylserine and the display of TUNEL-positive nuclei. We also show that H(2)O(2)-mediated stress leads to up-regulation of the 20S proteasome and suppression of ubiquitinylation activities. These findings suggest that deletion of the apoptotic-related caspase-like gene leads to a large H(2)O(2)-dependent accumulation of oxidized proteins and up-regulation of 20S proteasome activity. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Khan, Mohammed A S AU - Chock, P Boon AU - Stadtman, Earl R AD - Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-8012, USA. Y1 - 2005/11/29/ PY - 2005 DA - 2005 Nov 29 SP - 17326 EP - 17331 VL - 102 IS - 48 SN - 0027-8424, 0027-8424 KW - Phosphatidylserines KW - 0 KW - Saccharomyces cerevisiae Proteins KW - Hydrogen Peroxide KW - BBX060AN9V KW - Caspases KW - EC 3.4.22.- KW - MCA1 protein, S cerevisiae KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Index Medicus KW - Protein Carbonylation -- drug effects KW - Hydrogen Peroxide -- toxicity KW - In Situ Nick-End Labeling KW - Immunoblotting KW - Phosphatidylserines -- metabolism KW - Up-Regulation -- drug effects KW - Proteasome Endopeptidase Complex -- drug effects KW - Flow Cytometry KW - Saccharomyces cerevisiae -- genetics KW - Apoptosis -- genetics KW - Saccharomyces cerevisiae -- physiology KW - Saccharomyces cerevisiae Proteins -- genetics KW - Oxidative Stress -- genetics KW - Caspases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68845691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Knockout+of+caspase-like+gene%2C+YCA1%2C+abrogates+apoptosis+and+elevates+oxidized+proteins+in+Saccharomyces+cerevisiae.&rft.au=Khan%2C+Mohammed+A+S%3BChock%2C+P+Boon%3BStadtman%2C+Earl+R&rft.aulast=Khan&rft.aufirst=Mohammed+A&rft.date=2005-11-29&rft.volume=102&rft.issue=48&rft.spage=17326&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-05-22 N1 - Date created - 2005-11-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2000 Mar 10;275(10):7337-42 [10702305] Curr Genet. 2002 Jul;41(4):208-16 [12172961] Annu Rev Neurosci. 2000;23:73-87 [10845059] Biochimie. 2001 Mar-Apr;83(3-4):301-10 [11295490] Mol Biol Cell. 2001 Aug;12(8):2422-32 [11514626] Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):12920-5 [11606777] Electrophoresis. 2004 May;25(9):1334-41 [15174056] Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11560-5 [15284441] FEMS Yeast Res. 2004 Nov;5(2):111-7 [15489193] FEMS Yeast Res. 2004 Nov;5(2):141-7 [15489197] J Biol Chem. 1985 Oct 15;260(23):12600-6 [2864341] Curr Top Cell Regul. 1986;28:291-337 [2878793] J Biol Chem. 1987 Jun 15;262(17):8227-34 [3597373] J Biol Chem. 1987 Jul 15;262(20):9895-901 [3036875] Annu Rev Biochem. 1993;62:797-821 [8352601] FEBS Lett. 2002 Sep 25;528(1-3):23-6 [12297273] Free Radic Biol Med. 2002 Nov 1;33(9):1209-20 [12398929] Science. 2003 Mar 14;299(5613):1751-3 [12610228] Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14327-32 [14623979] J Cell Biol. 2004 Feb 16;164(4):501-7 [14970189] Chem Res Toxicol. 1993 Jul-Aug;6(4):430-3 [8374038] Methods Enzymol. 1994;233:346-57 [8015469] Yeast. 1994 Sep;10(9):1141-55 [7754704] Pharmacol Ther. 1996;72(1):37-50 [8981570] Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15036-40 [8986759] Microsc Res Tech. 1997 Jan 15;36(2):123-9 [9015258] Drug Metab Rev. 1998 May;30(2):225-43 [9606602] Biochem J. 1998 Nov 1;335 ( Pt 3):637-42 [9794805] Nature. 1998 Nov 12;396(6707):119-22 [9823889] Exp Cell Res. 1999 May 1;248(2):381-90 [10222130] J Cell Biol. 1999 May 17;145(4):757-67 [10330404] J Biol Chem. 2004 Dec 10;279(50):52623-9 [15381697] Biochim Biophys Acta. 2005 Jan 17;1703(2):261-6 [15680234] J Biol Chem. 2005 Apr 15;280(15):14691-9 [15691845] Mol Cell. 2002 Apr;9(4):911-7 [11983181] Hum Exp Toxicol. 2002 Feb;21(2):83 [12102501] Arch Biochem Biophys. 2002 Aug 15;404(2):279-84 [12147266] J Gerontol A Biol Sci Med Sci. 2000 May;55(5):B220-7 [10819308] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An inhibitor of TRPV1 channels isolated from funnel Web spider venom. AN - 68812062; 16300403 AB - Capsaicin receptor channels (TRPV1) are nonselective cation channels that integrate multiple noxious stimuli in sensory neurons. In an effort to identify new inhibitors of these channels we screened a venom library for activity against TRPV1 channels and found robust inhibitory activity in venom from Agelenopsis aperta, a north American funnel web spider. Fractionation of the venom using reversed-phase HPLC resulted in the purification of two acylpolyamine toxins, AG489 and AG505, which inhibit TRPV1 channels from the extracellular side of the membrane. The activity of AG489 was characterized further, and the toxin was found to inhibit TRPV1 channels with a K(i) of 0.3 microM at -40 mV. Inhibition of TRPV1 channels by AG489 is strongly voltage-dependent, with relief of inhibition at positive voltages, consistent with the toxin inhibiting the channel through a pore-blocking mechanism. We used scanning mutagenesis throughout the TM5-TM6 linker, a region thought to form the outer pore of TRPV1 channels, to identify pore mutations that alter toxin affinity. Four mutants dramatically decrease toxin affinity and several mutants increase toxin affinity, consistent with the notion that the TM5-TM6 linker forms the outer vestibule of TRPV1 channels and that AG489 is a pore blocker. JF - Biochemistry AU - Kitaguchi, Tetsuya AU - Swartz, Kenton J AD - Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2005/11/29/ PY - 2005 DA - 2005 Nov 29 SP - 15544 EP - 15549 VL - 44 IS - 47 SN - 0006-2960, 0006-2960 KW - Agatoxins KW - 0 KW - FTX, spider toxin KW - Polyamines KW - Spider Venoms KW - TRPV Cation Channels KW - Trpv1 protein, rat KW - agatoxin-489 KW - 128549-96-2 KW - Index Medicus KW - Animals KW - Models, Molecular KW - Chemical Fractionation KW - Spider Venoms -- chemistry KW - Electrophysiology KW - Mutagenesis KW - Rats KW - Transfection KW - Xenopus KW - Oocytes KW - Spider Venoms -- genetics KW - Spider Venoms -- pharmacology KW - Polyamines -- pharmacology KW - Polyamines -- chemistry KW - TRPV Cation Channels -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68812062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=An+inhibitor+of+TRPV1+channels+isolated+from+funnel+Web+spider+venom.&rft.au=Kitaguchi%2C+Tetsuya%3BSwartz%2C+Kenton+J&rft.aulast=Kitaguchi&rft.aufirst=Tetsuya&rft.date=2005-11-29&rft.volume=44&rft.issue=47&rft.spage=15544&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-03 N1 - Date created - 2005-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Modulation of Werner syndrome protein function by a single mutation in the conserved RecQ domain. AN - 68815968; 16150736 AB - Naturally occurring mutations in the human RECQ3 gene result in truncated Werner protein (WRN) and manifest as a rare premature aging disorder, Werner syndrome. Cellular and biochemical studies suggest a multifaceted role of WRN in DNA replication, DNA repair, recombination, and telomere maintenance. The RecQ C-terminal (RQC) domain of WRN was determined previously to be the major site of interaction for DNA and proteins. By using site-directed mutagenesis in the WRN RQC domain, we determined which amino acids might be playing a critical role in WRN function. A site-directed mutation at Lys-1016 significantly decreased WRN binding to fork or bubble DNA substrates. Moreover, the Lys-1016 mutation markedly reduced WRN helicase activity on fork, D-loop, and Holliday junction substrates in addition to reducing significantly the ability of WRN to stimulate FEN-1 incision activities. Thus, DNA binding mediated by the RQC domain is crucial for WRN helicase and its coordinated functions. Our nuclear magnetic resonance data on the three-dimensional structure of the wild-type RQC and Lys-1016 mutant proteins display a remarkable similarity in their structures. JF - The Journal of biological chemistry AU - Lee, Jae Wan AU - Kusumoto, Rika AU - Doherty, Kevin M AU - Lin, Guang-Xin AU - Zeng, Wangyong AU - Cheng, Wen-Hsing AU - von Kobbe, Cayetano AU - Brosh, Robert M AU - Hu, Jin-Shan AU - Bohr, Vilhelm A AD - Laboratory of Molecular Gerontology, NIA, National Institutes of Health, Baltimore, Maryland 21224-6825, USA. Y1 - 2005/11/25/ PY - 2005 DA - 2005 Nov 25 SP - 39627 EP - 39636 VL - 280 IS - 47 SN - 0021-9258, 0021-9258 KW - Recombinant Proteins KW - 0 KW - DNA KW - 9007-49-2 KW - Exodeoxyribonucleases KW - EC 3.1.- KW - Adenosine Triphosphatases KW - EC 3.6.1.- KW - RECQL protein, human KW - DNA Helicases KW - EC 3.6.4.- KW - RecQ Helicases KW - EC 3.6.4.12 KW - WRN protein, human KW - Werner Syndrome Helicase KW - Index Medicus KW - Humans KW - Mutagenesis, Site-Directed KW - Werner Syndrome -- etiology KW - Amino Acid Motifs KW - Recombinant Proteins -- metabolism KW - In Vitro Techniques KW - Molecular Sequence Data KW - Adenosine Triphosphatases -- chemistry KW - Recombinant Proteins -- chemistry KW - Sequence Homology, Amino Acid KW - Adenosine Triphosphatases -- genetics KW - Adenosine Triphosphatases -- metabolism KW - Amino Acid Sequence KW - Recombinant Proteins -- genetics KW - Mutation, Missense KW - Werner Syndrome -- metabolism KW - Base Sequence KW - Conserved Sequence KW - Nuclear Magnetic Resonance, Biomolecular KW - DNA -- genetics KW - Protein Structure, Tertiary KW - Werner Syndrome -- genetics KW - Cell Line KW - DNA Helicases -- chemistry KW - DNA Helicases -- metabolism KW - DNA Helicases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68815968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Modulation+of+Werner+syndrome+protein+function+by+a+single+mutation+in+the+conserved+RecQ+domain.&rft.au=Lee%2C+Jae+Wan%3BKusumoto%2C+Rika%3BDoherty%2C+Kevin+M%3BLin%2C+Guang-Xin%3BZeng%2C+Wangyong%3BCheng%2C+Wen-Hsing%3Bvon+Kobbe%2C+Cayetano%3BBrosh%2C+Robert+M%3BHu%2C+Jin-Shan%3BBohr%2C+Vilhelm+A&rft.aulast=Lee&rft.aufirst=Jae&rft.date=2005-11-25&rft.volume=280&rft.issue=47&rft.spage=39627&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-03 N1 - Date created - 2005-11-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The entomological inoculation rate and Plasmodium falciparum infection in African children AN - 17093271; 6718753 AB - Malaria is an important cause of global morbidity and mortality. The fact that some people are bitten more often than others has a large effect on the relationship between risk factors and prevalence of vector-borne diseases. Here we develop a mathematical framework that allows us to estimate the heterogeneity of infection rates from the relationship between rates of infectious bites and community prevalence. We apply this framework to a large, published data set that combines malaria measurements from more than 90 communities. We find strong evidence that heterogeneous biting or heterogeneous susceptibility to infection are important and pervasive factors determining the prevalence of infection: 20% of people receive 80% of all infections. We also find that individual infections last about six months on average, per infectious bite, and children who clear infections are not immune to new infections. The results have important implications for public health interventions: the success of malaria control will depend heavily on whether efforts are targeted at those who are most at risk of infection. JF - Nature AU - Smith, D L AU - Dushoff, J AU - Snow, R W AU - Hay, SI AD - Fogarty International Center, National Institutes of Health, Building 16, 16 Center Drive, Bethesda, Maryland 20892, USA, smitdave@helix.nih.gov Y1 - 2005/11/24/ PY - 2005 DA - 2005 Nov 24 SP - 492 EP - 495 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com] VL - 438 IS - 7067 SN - 0028-0836, 0028-0836 KW - African children KW - Mosquitoes KW - Entomology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 3: Aquatic Pollution & Environmental Quality KW - Biological vectors KW - Human diseases KW - Vector-borne diseases KW - Disease control KW - Culicidae KW - Malaria KW - Plasmodium falciparum KW - Infection KW - Risks KW - Public health KW - Disease transmission KW - Socioeconomic aspects KW - Biting KW - Africa KW - K 03090:Protozoa: human KW - Z 05206:Medical & veterinary entomology KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17093271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=The+entomological+inoculation+rate+and+Plasmodium+falciparum+infection+in+African+children&rft.au=Smith%2C+D+L%3BDushoff%2C+J%3BSnow%2C+R+W%3BHay%2C+SI&rft.aulast=Smith&rft.aufirst=D&rft.date=2005-11-24&rft.volume=438&rft.issue=7067&rft.spage=492&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/10.1038%2Fnature04024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-05-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Biological vectors; Human diseases; Socioeconomic aspects; Disease control; Malaria; Risks; Disease transmission; Public health; Biting; Vector-borne diseases; Infection; Culicidae; Plasmodium falciparum; Africa DO - http://dx.doi.org/10.1038/nature04024 ER - TY - JOUR T1 - Decreased levels of CXC-chemokines in serum of benzene-exposed workers identified by array-based proteomics. AN - 68821798; 16286641 AB - Benzene is an important industrial chemical and environmental contaminant that causes leukemia. To obtain mechanistic insight into benzene's mechanism of action, we examined the impact of benzene on the human serum proteome in a study of exposed healthy shoe-factory workers and unexposed controls. Two sequential studies were performed, each using sera from 10 workers exposed to benzene (overall mean benzene air level >30 ppm) and 10 controls. Serum samples were subjected to anion-exchange fractionation and bound to three types of ProteinChip arrays (Ciphergen Biosystems, Fremont, CA) [hydrophobic (H50), metal affinity (IMAC3-Cu), and cation exchange (WCX2)]. Protein-expression patterns were detected by surface-enhanced laser desorption/ionization (SELDI)-TOF MS. Three proteins (4.1, 7.7, and 9.3 kDa) were consistently down-regulated in exposed compared with control subjects in both studies. All proteins were highly inversely correlated with individual estimates of benzene exposure (r > 0.75). The 7.7- and 9.3-kDa proteins were subsequently identified as platelet factor (PF)4 and connective tissue activating peptide (CTAP)-III. Initial proteomic results for PF4 and CTAP-III were subsequently confirmed in a single experiment using a ProteinChip-array-based immunoassay(Ciphergen Biosystems). The altered expression of the platelet-derived CXC-chemokines (40% and 63% for PF4 and CTAP-III, respectively) could not be explained by changes in absolute platelet counts. Thus, SELDI-TOF analysis of a limited number of exposed and unexposed subjects revealed that lowered expression of PF4 and CTAP-III proteins is a potential biomarker of benzene's early biologic effects and may play a role in the immunosuppressive effects of benzene. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Vermeulen, Roel AU - Lan, Qing AU - Zhang, Luoping AU - Gunn, Laura AU - McCarthy, Diane AU - Woodbury, Ronald L AU - McGuire, Marielena AU - Podust, Vladimir N AU - Li, Guilan AU - Chatterjee, Nilanjan AU - Mu, Ruidong AU - Yin, Songnian AU - Rothman, Nathaniel AU - Smith, Martyn T AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 6120 Executive Boulevard, Rockville, MD 20852, USA. vermeulr@mail.nih.gov Y1 - 2005/11/22/ PY - 2005 DA - 2005 Nov 22 SP - 17041 EP - 17046 VL - 102 IS - 47 SN - 0027-8424, 0027-8424 KW - Biomarkers KW - 0 KW - Chemokines, CXC KW - Benzene KW - J64922108F KW - Index Medicus KW - Protein Array Analysis KW - Humans KW - Linear Models KW - Biomarkers -- blood KW - Proteomics KW - Occupational Exposure -- adverse effects KW - Chemokines, CXC -- blood KW - Benzene -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68821798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Decreased+levels+of+CXC-chemokines+in+serum+of+benzene-exposed+workers+identified+by+array-based+proteomics.&rft.au=Vermeulen%2C+Roel%3BLan%2C+Qing%3BZhang%2C+Luoping%3BGunn%2C+Laura%3BMcCarthy%2C+Diane%3BWoodbury%2C+Ronald+L%3BMcGuire%2C+Marielena%3BPodust%2C+Vladimir+N%3BLi%2C+Guilan%3BChatterjee%2C+Nilanjan%3BMu%2C+Ruidong%3BYin%2C+Songnian%3BRothman%2C+Nathaniel%3BSmith%2C+Martyn+T&rft.aulast=Vermeulen&rft.aufirst=Roel&rft.date=2005-11-22&rft.volume=102&rft.issue=47&rft.spage=17041&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-12 N1 - Date created - 2005-11-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Epidemiol. 1988 Mar;127(3):419-39 [3277397] Environ Health Perspect. 2005 Jun;113(6):801-7 [15929907] Am J Ind Med. 1996 Mar;29(3):236-46 [8833776] J Leukoc Biol. 2000 Apr;67(4):471-8 [10770278] J Biol Chem. 2000 Jul 7;275(27):20374-81 [10877842] Blood. 2000 Nov 1;96(9):2965-72 [11049972] Immunol Rev. 2000 Oct;177:204-16 [11138777] Curr Opin Rheumatol. 2001 May;13(3):202-8 [11333349] Transfus Med. 2001 Dec;11(6):403-17 [11851938] J Immunol. 2002 Jul 15;169(2):770-7 [12097379] Am J Ind Med. 2002 Oct;42(4):275-85 [12271475] Semin Immunol. 2003 Feb;15(1):15-21 [12495637] Lung Cancer. 2003 Jun;40(3):267-79 [12781425] BJU Int. 2003 Aug;92(3):223-5 [12887471] Arch Otolaryngol Head Neck Surg. 2004 Jan;130(1):98-104 [14732777] Ann Occup Hyg. 2004 Mar;48(2):105-16 [14990432] Novartis Found Symp. 2004;256:173-84; discussion 184-8, 259-69 [15027490] Lab Invest. 2004 Jul;84(7):845-56 [15107802] Am J Ind Med. 1985;7(5-6):395-402 [4003402] Toxicol Appl Pharmacol. 1985 Sep 30;80(3):502-10 [2863880] Environ Health Perspect. 1996 Dec;104 Suppl 6:1339-41 [9118917] Environ Health Perspect. 1996 Dec;104 Suppl 6:1349-52 [9118919] Am J Ind Med. 1997 Mar;31(3):287-95 [9055951] Blood. 1997 Apr 1;89(7):2328-35 [9116276] J Natl Cancer Inst. 1997 Jul 16;89(14):1065-71 [9230889] Science. 2004 Dec 3;306(5702):1774-6 [15576619] Stat Med. 1990 Jul;9(7):811-8 [2218183] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Immunohistochemical evaluation of heat shock proteins in normal and preinvasive lesions of the cervix. AN - 68689266; 16112431 AB - Heat Shock Proteins (HSPs) are molecular chaperons with multiple functions relating to cellular homeostasis. Primary, HSPs are expressed in response to cellular stresses that may also include carcinogenesis. Patterns of expression have not been extensively evaluated in the multi-step carcinogenesis of cervical cancer (Normal --> HPV infection --> Cervical Precancer --> Cancer). We evaluated the expression of HSP40, HSP60, HSP70, and HSP90 in normal tissues (N=30), in cervical intraepithelial neoplasia grade 1 (CIN1)(synonymous with productive HPV infections) (N=32), and in CIN3 (cervical precancer)(N=25) by immunohistochemistry staining (graded 0-3) and compared the results to p16INK4a, a biomarker of oncogenic HPV infections and CIN3. We found strong patterns of increased HSP40, HSP60, and HSP70 immunostaining with increasing severity of the lesion in a manner similar to p16INK4a (P(Trend)<0.0005). No difference in staining intensity by grade of lesion was observed for HSP90 (P(Trend)=0.8). Tissue patterns in CIN3 of diffuse immunostaining for HSP40 and HSP70 were analogous to those observed for p16INK4a; HSP60 immunostaining appeared more punctate within cells than for other antigens although similar tissue patterns were observed. We conclude that HSP40, HSP60, and HSP70 expressions are up-regulated in response to the development of CIN3 akin to p16INK4a expression. JF - Cancer letters AU - Castle, Philip E AU - Ashfaq, Raheela AU - Ansari, Faryal AU - Muller, Carolyn Y AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA. castlep@mail.nih.gov Y1 - 2005/11/18/ PY - 2005 DA - 2005 Nov 18 SP - 245 EP - 252 VL - 229 IS - 2 SN - 0304-3835, 0304-3835 KW - Biomarkers, Tumor KW - 0 KW - Cyclin-Dependent Kinase Inhibitor p16 KW - Heat-Shock Proteins KW - Index Medicus KW - Humans KW - Papillomavirus Infections -- complications KW - Precancerous Conditions -- metabolism KW - Precancerous Conditions -- pathology KW - Precancerous Conditions -- virology KW - Cyclin-Dependent Kinase Inhibitor p16 -- biosynthesis KW - Tumor Virus Infections -- metabolism KW - Biomarkers, Tumor -- analysis KW - Up-Regulation KW - Immunohistochemistry KW - Female KW - Papillomavirus Infections -- metabolism KW - Tumor Virus Infections -- complications KW - Cervical Intraepithelial Neoplasia -- pathology KW - Uterine Cervical Neoplasms -- metabolism KW - Cervical Intraepithelial Neoplasia -- metabolism KW - Heat-Shock Proteins -- biosynthesis KW - Cervical Intraepithelial Neoplasia -- virology KW - Uterine Cervical Neoplasms -- pathology KW - Uterine Cervical Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68689266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Immunohistochemical+evaluation+of+heat+shock+proteins+in+normal+and+preinvasive+lesions+of+the+cervix.&rft.au=Castle%2C+Philip+E%3BAshfaq%2C+Raheela%3BAnsari%2C+Faryal%3BMuller%2C+Carolyn+Y&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2005-11-18&rft.volume=229&rft.issue=2&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-11 N1 - Date created - 2005-10-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Potential hazard of pharmacokinetic interactions between lopinavir-ritonavir protease inhibitors and irinotecan AN - 21046234; 6585921 AB - The use of concomitant chemotherapy and highly active antiretroviral therapy (HAART) has been demonstrated to be feasible and effective in reducing morbidity associated with opportunistic infections and to improve overall survival in patients with HIV-related malignances. However, such combination therapy causes severe toxicity, including neutropenia. It has been hypothesized that such unpredictable toxicity can be related to pharmacokinetic interactions. JF - AIDS AU - Corona, G AU - Vaccher, E AU - Cattarossi, G AU - Sartor, I AU - Toffoli, G AD - Division of Medical Oncology A, National Cancer Institute CRO-IRCCS, Aviano (PN), Italy Y1 - 2005/11/18/ PY - 2005 DA - 2005 Nov 18 SP - 2043 EP - 2044 VL - 19 IS - 17 SN - 0269-9370, 0269-9370 KW - HIV KW - irinotecan KW - lopinavir-ritonavir protease inhibitors KW - Immunology Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts; Virology & AIDS Abstracts KW - Acquired immune deficiency syndrome KW - Chemotherapy KW - Proteinase inhibitors KW - Irinotecan KW - Survival KW - Toxicity KW - chemotherapy KW - Pharmacokinetics KW - Morbidity KW - Opportunist infection KW - Neutropenia KW - Human immunodeficiency virus KW - highly active antiretroviral therapy KW - antiretroviral agents KW - infection KW - Side effects KW - X 24114:Metabolism KW - V 22002:AIDS: Molecular and in vitro aspects KW - F 06910:Microorganisms & Parasites KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21046234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Potential+hazard+of+pharmacokinetic+interactions+between+lopinavir-ritonavir+protease+inhibitors+and+irinotecan&rft.au=Corona%2C+G%3BVaccher%2C+E%3BCattarossi%2C+G%3BSartor%2C+I%3BToffoli%2C+G&rft.aulast=Corona&rft.aufirst=G&rft.date=2005-11-18&rft.volume=19&rft.issue=17&rft.spage=2043&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-02-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Neutropenia; highly active antiretroviral therapy; Chemotherapy; Irinotecan; Proteinase inhibitors; Survival; Toxicity; Morbidity; Pharmacokinetics; Opportunist infection; Acquired immune deficiency syndrome; antiretroviral agents; infection; Side effects; chemotherapy; Human immunodeficiency virus ER - TY - CPAPER T1 - Production of Reactive Oxygen Species in Both Human and Mouse Mast Cells is Lipoxygenase-Dependent and Plays a Facilitatory Role in Antigen Mediated Cytokine Secretion T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39768844; 4051721 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Coleman, John W AU - Metcalfe, Dean D AU - Swindle, Emily J Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Mast cells KW - Reactive oxygen species KW - Cytokines KW - Secretion KW - Antigens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39768844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Production+of+Reactive+Oxygen+Species+in+Both+Human+and+Mouse+Mast+Cells+is+Lipoxygenase-Dependent+and+Plays+a+Facilitatory+Role+in+Antigen+Mediated+Cytokine+Secretion&rft.au=Coleman%2C+John+W%3BMetcalfe%2C+Dean+D%3BSwindle%2C+Emily+J&rft.aulast=Coleman&rft.aufirst=John&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biting the Hand that Feeds: Use of a Novel DMPO-Protein Antibody in Detection of a Drug-Induced Myeloperoxidase Radical Adduct Upon Myeloperoxidase-Catalyzed Peroxidation of Aminoglutethimide T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39768211; 4051644 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Bonini, Marcelo G AU - Mason, Ronald P AU - Siraki, Arno G Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Feeds KW - Adducts KW - Biting KW - Peroxidation KW - Antibodies KW - Radicals KW - Peroxidase KW - Hand KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39768211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Biting+the+Hand+that+Feeds%3A+Use+of+a+Novel+DMPO-Protein+Antibody+in+Detection+of+a+Drug-Induced+Myeloperoxidase+Radical+Adduct+Upon+Myeloperoxidase-Catalyzed+Peroxidation+of+Aminoglutethimide&rft.au=Bonini%2C+Marcelo+G%3BMason%2C+Ronald+P%3BSiraki%2C+Arno+G&rft.aulast=Bonini&rft.aufirst=Marcelo&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Imaging Tissue Redox Staus Using MRI and Redox Sensitive Paramagnetic Contrast Agents: Applications for Tumor Imaging T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39767150; 4051800 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Hyodo, Fuminori AU - Matsumoto, Ken-ichiro AU - Matsumoto, Atsuko AU - Mitchell, James AU - Murali, Cherukuri AU - Subramanian, Sankaran Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Magnetic resonance imaging KW - Contrast media KW - Redox reactions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39767150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Imaging+Tissue+Redox+Staus+Using+MRI+and+Redox+Sensitive+Paramagnetic+Contrast+Agents%3A+Applications+for+Tumor+Imaging&rft.au=Hyodo%2C+Fuminori%3BMatsumoto%2C+Ken-ichiro%3BMatsumoto%2C+Atsuko%3BMitchell%2C+James%3BMurali%2C+Cherukuri%3BSubramanian%2C+Sankaran&rft.aulast=Hyodo&rft.aufirst=Fuminori&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nitrite Regulates Mitochondrial Respiration and Limits Reperfusion Injury T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39763672; 4052082 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Gladwin, Mark AU - Huang, Zhi AU - Lefer, David AU - Ringwood, Lorna AU - Sack, Michael AU - Shiva, Sruti Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Nitrite KW - Respiration KW - Injuries KW - Mitochondria KW - Reperfusion KW - Electron transport KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39763672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Nitrite+Regulates+Mitochondrial+Respiration+and+Limits+Reperfusion+Injury&rft.au=Gladwin%2C+Mark%3BHuang%2C+Zhi%3BLefer%2C+David%3BRingwood%2C+Lorna%3BSack%2C+Michael%3BShiva%2C+Sruti&rft.aulast=Gladwin&rft.aufirst=Mark&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Catalase Inactivation by Hypochlorite Correlates with Protein Radical Formation, Aggregation and Heme Modification T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39755226; 4051626 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Atanassov, Boyko S AU - Bonini, Marcelo G AU - Mason, Ronald P AU - Siraki, Arno G Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Heme KW - Catalase KW - Radicals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39755226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Catalase+Inactivation+by+Hypochlorite+Correlates+with+Protein+Radical+Formation%2C+Aggregation+and+Heme+Modification&rft.au=Atanassov%2C+Boyko+S%3BBonini%2C+Marcelo+G%3BMason%2C+Ronald+P%3BSiraki%2C+Arno+G&rft.aulast=Atanassov&rft.aufirst=Boyko&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mass Spectral Analysis of Protein-Based Radicals Using Stable Nitroxide Radicals: The Spin Scavenging Approach T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39754566; 4051813 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Deterding, Leesa AU - Lardinois, Olivier AU - Mason, Ronald AU - Tomer, Kenneth Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Radicals KW - Nitroxide KW - Spectral analysis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39754566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Mass+Spectral+Analysis+of+Protein-Based+Radicals+Using+Stable+Nitroxide+Radicals%3A+The+Spin+Scavenging+Approach&rft.au=Deterding%2C+Leesa%3BLardinois%2C+Olivier%3BMason%2C+Ronald%3BTomer%2C+Kenneth&rft.aulast=Deterding&rft.aufirst=Leesa&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Pharmacokinetic Measurement Using Electron Paramagnetic Resonance Spectroscopy and Simulation of in Vivo Decay of Various Nitroxyl Radicals in Mouse Blood T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39750890; 4051805 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Krishna, Murali AU - Matsumoto, Ken-ichiro AU - Mitchell, James Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Decay KW - Blood KW - Spectroscopy KW - Simulation KW - Pharmacokinetics KW - E.S.R. KW - Radicals KW - Resonance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39750890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Novel+Pharmacokinetic+Measurement+Using+Electron+Paramagnetic+Resonance+Spectroscopy+and+Simulation+of+in+Vivo+Decay+of+Various+Nitroxyl+Radicals+in+Mouse+Blood&rft.au=Krishna%2C+Murali%3BMatsumoto%2C+Ken-ichiro%3BMitchell%2C+James&rft.aulast=Krishna&rft.aufirst=Murali&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Atorvastatin Therapy Restores Nitric Oxide-Dependent Vascular Responsiveness in Patients with Sickle Cell Disease T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39750799; 4051778 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Cannon, Richard AU - Dejam, Andre AU - Gladwin, Mark AU - Hunter, Christian AU - Hunter, Lori AU - Kato, Gregory AU - Lin, Elaina AU - Machado, Roberto AU - Mack, Kyle AU - Sachdev, Vandana AU - Tremonti, Carole Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Vascular system KW - Sickle cell disease KW - Atorvastatin KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39750799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Atorvastatin+Therapy+Restores+Nitric+Oxide-Dependent+Vascular+Responsiveness+in+Patients+with+Sickle+Cell+Disease&rft.au=Cannon%2C+Richard%3BDejam%2C+Andre%3BGladwin%2C+Mark%3BHunter%2C+Christian%3BHunter%2C+Lori%3BKato%2C+Gregory%3BLin%2C+Elaina%3BMachado%2C+Roberto%3BMack%2C+Kyle%3BSachdev%2C+Vandana%3BTremonti%2C+Carole&rft.aulast=Cannon&rft.aufirst=Richard&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Noninvasive EPR Assessment of Tissue Oxygenation Using Water Soluble Paramagnetic Probes T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39747266; 4051810 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Devasahayam, Nallathamby AU - Hyodo, Fuminori AU - Koscielniak, Janusz AU - Krishna, Murali AU - Matsumoto, Atsuko AU - Matsumoto, Ken-ichiro AU - Mitchell, James AU - Sowers, Anastasia AU - Subramanian, Sankaran Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Oxygenation KW - Probes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39747266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Noninvasive+EPR+Assessment+of+Tissue+Oxygenation+Using+Water+Soluble+Paramagnetic+Probes&rft.au=Devasahayam%2C+Nallathamby%3BHyodo%2C+Fuminori%3BKoscielniak%2C+Janusz%3BKrishna%2C+Murali%3BMatsumoto%2C+Atsuko%3BMatsumoto%2C+Ken-ichiro%3BMitchell%2C+James%3BSowers%2C+Anastasia%3BSubramanian%2C+Sankaran&rft.aulast=Devasahayam&rft.aufirst=Nallathamby&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Estimation of Redox Status of a Tumor Tissue in Mice Using Paramagnetic Nitroxyl Contrast Agent T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39747239; 4051806 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Cook, John AU - Hyodo, Fuminori AU - Krishna, Murali AU - Matsumoto, Ken-ichiro AU - Matsumoto, Atsuko AU - Mitchell, James AU - Murugesan, Ramachandran AU - Sowers, Anastasia AU - Subramanian, Sankaran Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Mice KW - Contrast media KW - Redox reactions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39747239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Estimation+of+Redox+Status+of+a+Tumor+Tissue+in+Mice+Using+Paramagnetic+Nitroxyl+Contrast+Agent&rft.au=Cook%2C+John%3BHyodo%2C+Fuminori%3BKrishna%2C+Murali%3BMatsumoto%2C+Ken-ichiro%3BMatsumoto%2C+Atsuko%3BMitchell%2C+James%3BMurugesan%2C+Ramachandran%3BSowers%2C+Anastasia%3BSubramanian%2C+Sankaran&rft.aulast=Cook&rft.aufirst=John&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Copper Catalyzed Protein Oxidation and its Modulation by Carbon Dioxide: Enhancement of Protein Radicals in Functioning Cells T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39720913; 4052037 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Mejiba, Sandra Gomez AU - Mason, Ronald AU - Ramirez, Dario Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Copper KW - Oxidation KW - Carbon dioxide KW - Radicals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39720913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Copper+Catalyzed+Protein+Oxidation+and+its+Modulation+by+Carbon+Dioxide%3A+Enhancement+of+Protein+Radicals+in+Functioning+Cells&rft.au=Mejiba%2C+Sandra+Gomez%3BMason%2C+Ronald%3BRamirez%2C+Dario&rft.aulast=Mejiba&rft.aufirst=Sandra&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Superoxide Fluxes Control NO-Induced Post-Translational Regulation of sGC, p53, and HIF-1a T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39712942; 4051917 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Thomas, Douglas AU - Wink, David Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Hypoxia-inducible factor 1^a KW - P53 protein KW - Superoxide KW - Post-translation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39712942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Superoxide+Fluxes+Control+NO-Induced+Post-Translational+Regulation+of+sGC%2C+p53%2C+and+HIF-1a&rft.au=Thomas%2C+Douglas%3BWink%2C+David&rft.aulast=Thomas&rft.aufirst=Douglas&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hydroethidine is Efficiently Oxidized by Singlet Oxygen T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39712257; 4051796 DE: JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Bilski, Piotr AU - Chignell, Colin F AU - DeRose, Eugene F AU - Karriker, Brian Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39712257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Hydroethidine+is+Efficiently+Oxidized+by+Singlet+Oxygen&rft.au=Bilski%2C+Piotr%3BChignell%2C+Colin+F%3BDeRose%2C+Eugene+F%3BKarriker%2C+Brian&rft.aulast=Bilski&rft.aufirst=Piotr&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proteomic Identification of Dysregulated Apolipoprotein Expression in Pulmonary Hypertension Secondary to Sickle Cell Disease T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39712164; 4051777 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Gladwin, Mark AU - Hoehn, Gerard AU - Kato, Gregory AU - Munson, Peter AU - Suffredini, Anthony AU - Xu, Xiuli AU - Yuditskaya, Susan Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - Hypertension KW - Apolipoproteins KW - Proteomics KW - Sickle cell disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39712164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Proteomic+Identification+of+Dysregulated+Apolipoprotein+Expression+in+Pulmonary+Hypertension+Secondary+to+Sickle+Cell+Disease&rft.au=Gladwin%2C+Mark%3BHoehn%2C+Gerard%3BKato%2C+Gregory%3BMunson%2C+Peter%3BSuffredini%2C+Anthony%3BXu%2C+Xiuli%3BYuditskaya%2C+Susan&rft.aulast=Gladwin&rft.aufirst=Mark&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nitroxides Inhibit the TNF-Alpha Initiated NF-kB Cytoplasmic to Nuclear Translocation T2 - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AN - 39709074; 4051867 JF - 12th Annual Meeting of Society for Free Radical Biology and Medicine (SFRBM's 12th) AU - Cook, John AU - Grimes, Kelly AU - Mitchell, James Y1 - 2005/11/16/ PY - 2005 DA - 2005 Nov 16 KW - NF-^KB protein KW - Nuclear transport KW - Nitroxide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39709074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.atitle=Nitroxides+Inhibit+the+TNF-Alpha+Initiated+NF-kB+Cytoplasmic+to+Nuclear+Translocation&rft.au=Cook%2C+John%3BGrimes%2C+Kelly%3BMitchell%2C+James&rft.aulast=Cook&rft.aufirst=John&rft.date=2005-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+Annual+Meeting+of+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM%27s+12th%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2005/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammatory stress. AN - 68805004; 16288013 AB - Activation of the p53 network plays a central role in the inflammatory stress response associated with ulcerative colitis and may modulate cancer risk in patients afflicted with this chronic disease. Here, we describe the gene expression profiles associated with four microenvironmental components of the inflammatory response (NO*, H2O2, DNA replication arrest, and hypoxia) that result in p53 stabilization and activation. Isogenic HCT116 and HCT116 TP53-/- colon cancer cells were exposed to the NO* donor Sper/NO, H2O2, hypoxia, or hydroxyurea, and their mRNA was analyzed using oligonucleotide microarrays. Overall, 1,396 genes changed in a p53-dependent manner (P < 0.001), with the majority representing a "unique" profile for each condition. Only 14 genes were common to all four conditions. Included were eight known p53 target genes. Hierarchical sample clustering distinguished early (1 and 4 hours) from late responses (8, 12, and 24 hours), and each treatment was differentiated from the others. Overall, NO* and hypoxia stimulated similar transcriptional responses. Gene ontology analysis revealed cell cycle as a key feature of stress responses and confirmed the similarity between NO* and hypoxia. Cell cycle profiles analyzed by flow cytometry showed that NO* and hypoxia induced quiescent S-phase and G2-M arrest. Using a novel bioinformatic algorithm, we identified several putative p53-responsive elements among the genes induced in a p53-dependent manner, including four [KIAA0247, FLJ12484, p53CSV (HSPC132), and CNK (PLK3)] common to all exposures. In summary, the inflammatory stress response is a complex, integrated biological network in which p53 is a key molecular node regulating gene expression. JF - Cancer research AU - Staib, Frank AU - Robles, Ana I AU - Varticovski, Lyuba AU - Wang, Xin W AU - Zeeberg, Barry R AU - Sirotin, Michail AU - Zhurkin, Victor B AU - Hofseth, Lorne J AU - Hussain, S Perwez AU - Weinstein, John N AU - Galle, Peter R AU - Harris, Curtis C AD - Laboratories of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, USA. Y1 - 2005/11/15/ PY - 2005 DA - 2005 Nov 15 SP - 10255 EP - 10264 VL - 65 IS - 22 SN - 0008-5472, 0008-5472 KW - Nitric Oxide Donors KW - 0 KW - Nitrogen Oxides KW - TP53 protein, human KW - Tumor Suppressor Protein p53 KW - spermine nitric oxide complex KW - 136587-13-8 KW - Spermine KW - 2FZ7Y3VOQX KW - Hydrogen Peroxide KW - BBX060AN9V KW - Index Medicus KW - Humans KW - Oxidative Stress -- genetics KW - HCT116 Cells KW - Cell Hypoxia KW - Reverse Transcriptase Polymerase Chain Reaction KW - Gene Expression Profiling KW - Oxidative Stress -- physiology KW - Spermine -- analogs & derivatives KW - Flow Cytometry KW - Cell Cycle KW - Tumor Suppressor Protein p53 -- biosynthesis KW - Inflammation -- etiology KW - Inflammation -- genetics KW - Inflammation -- metabolism KW - Tumor Suppressor Protein p53 -- genetics KW - Tumor Suppressor Protein p53 -- metabolism KW - Tumor Suppressor Protein p53 -- deficiency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68805004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=The+p53+tumor+suppressor+network+is+a+key+responder+to+microenvironmental+components+of+chronic+inflammatory+stress.&rft.au=Staib%2C+Frank%3BRobles%2C+Ana+I%3BVarticovski%2C+Lyuba%3BWang%2C+Xin+W%3BZeeberg%2C+Barry+R%3BSirotin%2C+Michail%3BZhurkin%2C+Victor+B%3BHofseth%2C+Lorne+J%3BHussain%2C+S+Perwez%3BWeinstein%2C+John+N%3BGalle%2C+Peter+R%3BHarris%2C+Curtis+C&rft.aulast=Staib&rft.aufirst=Frank&rft.date=2005-11-15&rft.volume=65&rft.issue=22&rft.spage=10255&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-18 N1 - Date created - 2005-11-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: BMC Bioinformatics. 2005;6:168 [15998470] Nature. 2005 Apr 28;434(7037):1138-43 [15858576] J Leukoc Biol. 1999 Dec;66(6):889-900 [10614769] Circ Res. 2000 Feb 18;86(3):319-25 [10679484] Genes Dev. 2000 Apr 15;14(8):981-93 [10783169] Cancer Res. 2000 Jul 1;60(13):3333-7 [10910033] Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12770-5 [11050162] Nature. 2000 Nov 16;408(6810):307-10 [11099028] J Biol Chem. 2001 Nov 23;276(47):43604-10 [11571296] Jpn J Cancer Res. 2001 Nov;92(11):1166-74 [11714440] Acta Oncol. 2001;40(6):696-701 [11765063] Mol Cell Biol. 2002 Mar;22(6):1834-43 [11865061] J Korean Med Sci. 2002 Oct;17(5):581-8 [12378005] Brain Res Mol Brain Res. 2002 Oct 30;107(1):9-16 [12414118] Cancer Res. 2002 Nov 1;62(21):6246-54 [12414654] Free Radic Biol Med. 2002 Nov 15;33(10):1419-32 [12419474] Nature. 2002 Dec 19-26;420(6917):860-7 [12490959] Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):143-8 [12518062] Nat Rev Cancer. 2003 Apr;3(4):276-85 [12671666] Curr Med Chem. 2003 May;10(10):845-55 [12678687] Free Radic Biol Med. 2003 Apr 15;34(8):955-68 [12684081] Bioessays. 2003 May;25(5):501-6 [12717820] Cell Death Differ. 2003 Apr;10(4):404-8 [12719716] Nature. 2003 May 15;423(6937):302-5 [12714971] Oncogene. 2003 Jun 5;22(23):3645-54 [12789273] Oncogene. 2003 Sep 1;22(37):5907-14 [12947397] Cancer Biol Ther. 2003 Jul-Aug;2(4):406-15 [14508115] Mutat Res. 2003 Nov 27;532(1-2):205-13 [14643437] J Clin Invest. 2003 Dec;112(12):1887-94 [14679184] J Biol Chem. 2004 Jan 23;279(4):2550-8 [14600153] Cancer Lett. 2004 Jan 20;203(2):217-24 [14732230] Free Radic Biol Med. 2004 Feb 15;36(4):507-16 [14975453] Trends Pharmacol Sci. 2004 Apr;25(4):177-81 [15116721] Cancer Res. 2004 May 1;64(9):3022-9 [15126337] J Biol Chem. 2004 Jun 11;279(24):25093-100 [15044452] Annu Rev Biochem. 2004;73:39-85 [15189136] Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8894-9 [15178764] Med Hypotheses. 1979 Sep;5(9):937-51 [522709] Proc Natl Acad Sci U S A. 1989 Feb;86(4):1183-7 [2919167] Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5258-65 [7777494] J Exp Med. 1995 Dec 1;182(6):1683-93 [7500013] Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2442-7 [8637893] J Clin Microbiol. 1996 Jul;34(7):1646-8 [8784562] Am J Physiol. 1998 Feb;274(2 Pt 1):L212-9 [9486205] Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8823-8 [9671763] Cancer J Sci Am. 1998 Jul-Aug;4(4):218-23 [9689978] Cell Mol Life Sci. 1998 Jul;54(7):684-95 [9711234] Curr Mol Med. 2004 Nov;4(7):741-51 [15579021] Toxicology. 2005 Mar 15;208(2):223-33 [15691587] Oncogene. 2005 Mar 3;24(10):1738-48 [15674334] Int J Radiat Oncol Biol Phys. 1999 Nov 1;45(4):1019-24 [10571211] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Yin-yang: balancing act of prostaglandins with opposing functions to regulate inflammation. AN - 68765371; 16272277 AB - For many years, cyclooxygenase-2 (COX-2), a critical enzyme for PG production, has been the favorite target for anti-inflammatory drug development. However, recent revelations regarding the adverse effects of selective COX-2 inhibitors have stimulated intense debate. Interestingly, in the early phase of inflammation, COX-2 facilitates inflammatory PG production while in the late phase it has anti-inflammatory effects. Moreover, although some PGs are proinflammatory, others have anti-inflammatory effects. Thus, it is likely that PGs with opposing effects maintain homeostasis, although the molecular mechanism(s) remains unclear. We report here that an inflammatory PG, PGD2, via its receptor, mediates the activation of NF-kappaB stimulating COX-2 gene expression. Most interestingly, an anti-inflammatory PG (PGA1) suppresses NF-kappaB activation and inhibits COX-2 gene expression. We propose that while pro- and anti-inflammatory PGs counteract each other to maintain homeostasis, selective COX-2 inhibitors may disrupt this balance, thereby resulting in reported adverse effects. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Mandal, Asim K AU - Zhang, Zhongjian AU - Kim, Sung-Jo AU - Tsai, Pei-Chih AU - Mukherjee, Anil B AD - Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2005/11/15/ PY - 2005 DA - 2005 Nov 15 SP - 6271 EP - 6273 VL - 175 IS - 10 SN - 0022-1767, 0022-1767 KW - Cyclooxygenase 2 Inhibitors KW - 0 KW - NF-kappa B KW - Prostaglandins KW - Prostaglandins A KW - RNA, Messenger KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - Prostaglandin D2 KW - RXY07S6CZ2 KW - prostaglandin A1 KW - VYR271N44P KW - Abridged Index Medicus KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Cyclooxygenase 2 -- physiology KW - Cyclooxygenase 2 Inhibitors -- adverse effects KW - Prostaglandins A -- pharmacology KW - Cyclooxygenase 2 -- genetics KW - Cyclooxygenase 2 Inhibitors -- pharmacology KW - Mice KW - RNA, Messenger -- genetics KW - Homeostasis -- drug effects KW - NF-kappa B -- genetics KW - NIH 3T3 Cells KW - Prostaglandin D2 -- pharmacology KW - RNA, Messenger -- metabolism KW - NF-kappa B -- metabolism KW - Prostaglandins -- physiology KW - Inflammation -- physiopathology KW - Inflammation -- genetics KW - Inflammation -- drug therapy KW - Inflammation -- immunology KW - Prostaglandins -- immunology KW - Prostaglandins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68765371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Yin-yang%3A+balancing+act+of+prostaglandins+with+opposing+functions+to+regulate+inflammation.&rft.au=Mandal%2C+Asim+K%3BZhang%2C+Zhongjian%3BKim%2C+Sung-Jo%3BTsai%2C+Pei-Chih%3BMukherjee%2C+Anil+B&rft.aulast=Mandal&rft.aufirst=Asim&rft.date=2005-11-15&rft.volume=175&rft.issue=10&rft.spage=6271&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-01-03 N1 - Date created - 2005-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The antileukemia effect of HLA-matched NK and NK-T cells in chronic myelogenous leukemia involves NKG2D-target-cell interactions. AN - 68755532; 16046526 AB - To study natural killer (NK) cell-mediated antileukemic activity in chronic myelogenous leukemia (CML), we investigated the ability of HLA-matched and mismatched CD56(+) cells to inhibit granulocyte macrophage-colony-forming unit (CFU-GM) formation by leukemic CD34(+) cells. In 14 HLA-identical donor-recipient pairs, donor CD56(+) cells inhibited CML CFU-GM comparably to effectors from 14 HLA-mismatched unrelated individuals (mean inhibition 42% +/- 9% vs 39.5% +/- 7% at a 10:1 effector-to-target (E/T) ratio), suggesting that killer inhibitory receptor (KIR) incompatibility was not essential for an antileukemic effect. Both CD56(+)CD3(-) (natural killer [NK]) and CD56(+)CD3(+)(NK-T) cells inhibited CFU-GM growth of CML but not normal CD34(+) cells. A mechanism for this leukemia-specific cytotoxicity was suggested by the abnormal overexpression of major histocompatibility class I chain-related gene A or gene B (MICA/B) on CML CD34 cells and their ability to bind the NK activation ligand NKG2D. However, in vivo, CML cells may avoid NK-cell-mediated immune destruction by immune escape, shedding MICA into the plasma, thereby down-regulating NKG2D on CML CD56(+) cells. JF - Blood AU - Sconocchia, Giuseppe AU - Lau, Michelle AU - Provenzano, Maurizio AU - Rezvani, Katayoun AU - Wongsena, Wachanan AU - Fujiwara, Hiroshi AU - Hensel, Nancy AU - Melenhorst, Jos AU - Li, Jonming AU - Ferrone, Soldano AU - Barrett, A John AD - Stem Cell Allotransplantation Section, Hematology Branch, National Heart Lung and Blood Institute, Department of Transfusion Medicine, Clinical Center, National Institutes of Health (NIH), Bethesda, MD 20892, USA. Y1 - 2005/11/15/ PY - 2005 DA - 2005 Nov 15 SP - 3666 EP - 3672 VL - 106 IS - 10 SN - 0006-4971, 0006-4971 KW - Antigens, CD KW - 0 KW - HLA Antigens KW - Histocompatibility Antigens Class I KW - KLRK1 protein, human KW - MHC class I-related chain A KW - MICB antigen KW - NK Cell Lectin-Like Receptor Subfamily K KW - Receptors, Immunologic KW - Receptors, Natural Killer Cell KW - Abridged Index Medicus KW - Index Medicus KW - Cytotoxicity Tests, Immunologic -- methods KW - Humans KW - Histocompatibility Antigens Class I -- immunology KW - Tumor Cells, Cultured KW - Histocompatibility Testing -- methods KW - Adult KW - Case-Control Studies KW - HLA Antigens -- immunology KW - Antigens, CD -- immunology KW - Female KW - Male KW - Receptors, Immunologic -- immunology KW - Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- immunology KW - Neoplastic Stem Cells -- immunology KW - T-Lymphocytes -- immunology KW - Killer Cells, Natural -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68755532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=The+antileukemia+effect+of+HLA-matched+NK+and+NK-T+cells+in+chronic+myelogenous+leukemia+involves+NKG2D-target-cell+interactions.&rft.au=Sconocchia%2C+Giuseppe%3BLau%2C+Michelle%3BProvenzano%2C+Maurizio%3BRezvani%2C+Katayoun%3BWongsena%2C+Wachanan%3BFujiwara%2C+Hiroshi%3BHensel%2C+Nancy%3BMelenhorst%2C+Jos%3BLi%2C+Jonming%3BFerrone%2C+Soldano%3BBarrett%2C+A+John&rft.aulast=Sconocchia&rft.aufirst=Giuseppe&rft.date=2005-11-15&rft.volume=106&rft.issue=10&rft.spage=3666&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-15 N1 - Date created - 2005-11-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Exp Med. 2000 Apr 17;191(8):1259-62 [10770793] Neoplasia. 2004 Sep-Oct;6(5):558-68 [15548365] Crit Rev Immunol. 2000;20(3):223-44 [10968372] Immunity. 2001 Feb;14(2):123-33 [11239445] Nat Immunol. 2001 Mar;2(3):255-60 [11224526] Immunol Rev. 2001 Jun;181:158-69 [11513137] Immunol Rev. 2001 Jun;181:185-92 [11513139] Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11521-6 [11562472] Cancer Res. 2002 Nov 1;62(21):6178-86 [12414645] Int J Hematol. 2002 Aug;76 Suppl 2:155-61 [12430918] Hum Immunol. 2003 Feb;64(2):183-93 [12559621] Blood. 2003 Aug 1;102(3):814-9 [12689936] Blood. 2003 Aug 15;102(4):1389-96 [12714493] J Immunol. 2003 Dec 15;171(12):6891-9 [14662896] Nature. 1975 Aug 7;256(5517):495-7 [1172191] Br J Cancer. 1983 Oct;48(4):507-14 [6626451] J Immunol. 1986 Jun 15;136(12):4480-6 [3086432] J Exp Med. 1986 Sep 1;164(3):814-25 [3489062] J Immunol Methods. 1987 Jun 26;100(1-2):83-90 [3298442] Blood. 1990 Jun 1;75(11):2250-62 [2189508] Leukemia. 1990 Apr;4(4):287-91 [2366584] Blood. 1990 Nov 15;76(10):2037-45 [2242425] Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7983-5 [1518825] Bone Marrow Transplant. 1993 Feb;11(2):133-8 [8435662] Med Clin (Barc). 1995 Jun 10;105(2):50-3 [7603094] Blood. 1996 Mar 15;87(6):2476-85 [8630414] Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12445-50 [8901601] Blood. 1997 Feb 1;89(3):957-64 [9028327] Ann Hematol. 1997 Jan;74(1):1-6 [9031607] Blood. 1998 Nov 1;92(9):3318-27 [9787169] Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6879-84 [10359807] Blood. 1999 Jul 1;94(1):333-9 [10381530] Science. 1999 Jul 30;285(5428):727-9 [10426993] Immunol Today. 2000 May;21(5):228-34 [10782054] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Breast cancer risk following radiotherapy for Hodgkin lymphoma: modification by other risk factors. AN - 68755152; 16051739 AB - The importance of genetic and other risk factors in the development of breast cancer after radiotherapy (RT) for Hodgkin lymphoma (HL) has not been determined. We analyzed data from a breast cancer case-control study (105 patients, 266 control subjects) conducted among 3 817 survivors of HL diagnosed at age 30 years or younger in 6 population-based cancer registries. Odds ratios (ORs) and excess relative risks (ERRs) were calculated using conditional regression. Women who received RT exposure (> or = 5 Gy radiation dose to the breast) had a 2.7-fold increased breast cancer risk (95% confidence interval (CI) 1.4-5.2), compared with those given less than 5 Gy. RT exposure (> or = 5 Gy) was associated with an OR of 0.8 (95% CI, 0.2-3.4) among women with a first- or second-degree family history of breast or ovarian cancer, and 5.8 (95% CI, 2.1-16.3) among all other women (interaction P = .03). History of a live birth appeared to increase the breast cancer risk associated with RT among women not treated with ovarian-damaging therapies. Breast cancer risk following RT varied little according to other factors. The additional increased relative risk of breast cancer after RT for HL is unlikely to be larger among women with a family history of breast or ovarian cancer than among other women. JF - Blood AU - Hill, Deirdre A AU - Gilbert, Ethel AU - Dores, Graça M AU - Gospodarowicz, Mary AU - van Leeuwen, Flora E AU - Holowaty, Eric AU - Glimelius, Bengt AU - Andersson, Michael AU - Wiklund, Tom AU - Lynch, Charles F AU - Van't Veer, Mars AU - Storm, Hans AU - Pukkala, Eero AU - Stovall, Marilyn AU - Curtis, Rochelle E AU - Allan, James M AU - Boice, John D AU - Travis, Lois B AD - Division of Cancer Epidemiology and Genetics and Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. dahill@salud.unm.edu Y1 - 2005/11/15/ PY - 2005 DA - 2005 Nov 15 SP - 3358 EP - 3365 VL - 106 IS - 10 SN - 0006-4971, 0006-4971 KW - Abridged Index Medicus KW - Index Medicus KW - Odds Ratio KW - Risk Factors KW - Radiotherapy Dosage KW - Humans KW - Adult KW - Retrospective Studies KW - Middle Aged KW - Female KW - Hodgkin Disease -- radiotherapy KW - Breast Neoplasms -- mortality KW - Neoplasms, Radiation-Induced -- etiology KW - Neoplasms, Second Primary -- etiology KW - Breast Neoplasms -- etiology KW - Neoplasms, Radiation-Induced -- mortality KW - Neoplasms, Second Primary -- mortality KW - Hodgkin Disease -- complications KW - Hodgkin Disease -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68755152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Breast+cancer+risk+following+radiotherapy+for+Hodgkin+lymphoma%3A+modification+by+other+risk+factors.&rft.au=Hill%2C+Deirdre+A%3BGilbert%2C+Ethel%3BDores%2C+Gra%C3%A7a+M%3BGospodarowicz%2C+Mary%3Bvan+Leeuwen%2C+Flora+E%3BHolowaty%2C+Eric%3BGlimelius%2C+Bengt%3BAndersson%2C+Michael%3BWiklund%2C+Tom%3BLynch%2C+Charles+F%3BVan%27t+Veer%2C+Mars%3BStorm%2C+Hans%3BPukkala%2C+Eero%3BStovall%2C+Marilyn%3BCurtis%2C+Rochelle+E%3BAllan%2C+James+M%3BBoice%2C+John+D%3BTravis%2C+Lois+B&rft.aulast=Hill&rft.aufirst=Deirdre&rft.date=2005-11-15&rft.volume=106&rft.issue=10&rft.spage=3358&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2005-12-15 N1 - Date created - 2005-11-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Lancet. 2001 Oct 27;358(9291):1389-99 [11705483] Cancer Causes Control. 1994 Mar;5(2):167-76 [8167264] J Clin Oncol. 2002 Aug 15;20(16):3484-94 [12177110] Clin Cancer Res. 2002 Dec;8(12):3813-9 [12473594] Cancer Epidemiol Biomarkers Prev. 2003 Apr;12(4):289-94 [12692102] Cancer Causes Control. 2003 Mar;14(2):151-60 [12749720] J Natl Cancer Inst. 2003 Jul 2;95(13):971-80 [12837833] JAMA. 2003 Jul 23;290(4):465-75 [12876089] Mol Cell. 2003 Nov;12(5):1087-99 [14636569] J Clin Oncol. 2003 Dec 1;21(23):4386-94 [14645429] Radiat Res. 2003 Dec;160(6):707-17 [14640793] Blood. 2004 Jan 1;103(1):283-90 [12969974] Epidemiology. 2004 Jul;15(4):422-7 [15232402] J Natl Cancer Inst. 1980 Jun;64(6):1459-66 [6929382] Prev Med. 1980 Nov;9(6):815-22 [7454704] N Engl J Med. 1994 Jul 7;331(1):5-9 [8202106] BMJ. 1994 Jun 25;308(6945):1672-4 [8025460] J Natl Cancer Inst Monogr. 1994;(16):15-24 [7999458] Br J Cancer. 1995 Aug;72(2):480-4 [7640236] Science. 1999 Nov 5;286(5442):1162-6 [10550055] J Clin Oncol. 1999 Apr;17(4):1259 [10561187] Cancer Epidemiol Biomarkers Prev. 1999 Dec;8(12):1043-50 [10613335] Carcinogenesis. 2000 May;21(5):1043-50 [10783331] Int J Radiat Biol. 2000 May;76(5):693-8 [10866292] Am J Epidemiol. 2000 Sep 15;152(6):514-27 [10997541] Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5134-9 [11320250] Br J Cancer. 2001 Aug 3;85(3):362-6 [11487266] Cancer Causes Control. 1995 Jul;6(4):283-91 [7548715] J Natl Cancer Inst. 1996 Mar 20;88(6):359-64 [8609645] Radiat Res. 1996 Jun;145(6):708-13 [8643830] Nature. 1997 Apr 24;386(6627):804-10 [9126738] Am J Hum Genet. 1998 Feb;62(2):334-45 [9463314] J Clin Oncol. 1998 Jul;16(7):2417-25 [9667259] J Natl Cancer Inst. 1999 Jun 2;91(11):943-9 [10359546] Cancer. 1983 Aug 1;52(3):435-8 [6688036] J Natl Cancer Inst. 1986 Sep;77(3):689-96 [3462410] Int J Cancer. 1989 Jul 15;44(1):7-16 [2744900] Arch Intern Med. 1990 Jan;150(1):191-4 [2297287] Br J Cancer. 1990 Jul;62(1):122-6 [2390471] N Engl J Med. 1992 Mar 19;326(12):781-5 [1538720] J Natl Cancer Inst. 1992 Aug 19;84(16):1245-50 [1640483] J Natl Cancer Inst. 1993 Oct 20;85(20):1679-85 [8411245] Int J Cancer. 1994 Feb 1;56(3):413-7 [8314329] Int J Cancer. 1994 Mar 15;56(6):793-801 [8119768] Radiat Res. 2002 Aug;158(2):220-35 [12105993] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Autonomic activity in relation to symptom ratings and reaction time in unmedicated patients with schizophrenia. AN - 68721907; 16006104 AB - High autonomic base levels and low responsivity are frequently observed in unmedicated patients with schizophrenia. We previously reported that patients in the present cohort, compared to normal controls, had high autonomic tonic baselines and low reactivity to the meaningful stimuli in a reaction time (RT) task but not to novel but innocuous stimuli. This paper explores further the role of autonomic activity in the pathogenesis of schizophrenia by relating differences in the autonomic variables among patients to symptom ratings and RT. Electrodermal activity and heart rate were recorded during rest, a tone series, and a RT task in 73 patients with schizophrenia taking placebo. Symptoms were rated with the Brief Psychiatric Rating Scale. Patients with higher autonomic baselines both at rest and under mild stress and those with greater electrodermal responsivity to both simple tones and the RT stimuli had more severe positive, "active", and total symptoms than patients with lower baselines and responsivity. RT was slower in patients with higher baselines. High autonomic activity in general, reactivity as well as base levels, under all conditions used in this study was associated with symptom severity independent of differences from controls. Thus elevated autonomic activity and responsivity may themselves be disturbing or index states that are disturbing in schizophrenia. Some patients might attempt to cope with novel or demanding situations and stimuli by a passive-avoidant strategy of low attention and effort in order to attenuate their responsivity. Less symptomatic patients may better cope in this manner. JF - Schizophrenia research AU - Zahn, Theodore P AU - Pickar, David AD - Laboratory of Brain and Cognition, National Institutes of Health, Bldg. 10. Rm. 4C104, MSC 1366, Bethesda, MD 20892-1366, USA. tpz@mail.nih.gov Y1 - 2005/11/15/ PY - 2005 DA - 2005 Nov 15 SP - 257 EP - 270 VL - 79 IS - 2-3 SN - 0920-9964, 0920-9964 KW - Index Medicus KW - Depression -- physiopathology KW - Analysis of Variance KW - Humans KW - Retrospective Studies KW - Anxiety -- physiopathology KW - Reflex, Startle -- physiology KW - Dose-Response Relationship, Radiation KW - Acoustic Stimulation -- methods KW - Depression -- etiology KW - Adult KW - Cohort Studies KW - Heart Rate -- physiology KW - Reflex, Startle -- radiation effects KW - Male KW - Anxiety -- etiology KW - Female KW - Functional Laterality KW - Galvanic Skin Response -- physiology KW - Brief Psychiatric Rating Scale -- statistics & numerical data KW - Autonomic Nervous System -- physiopathology KW - Schizophrenia -- physiopathology KW - Schizophrenia -- complications KW - Reaction Time -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68721907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Schizophrenia+research&rft.atitle=Autonomic+activity+in+relation+to+symptom+ratings+and+reaction+time+in+unmedicated+patients+with+schizophrenia.&rft.au=Zahn%2C+Theodore+P%3BPickar%2C+David&rft.aulast=Zahn&rft.aufirst=Theodore&rft.date=2005-11-15&rft.volume=79&rft.issue=2-3&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Schizophrenia+research&rft.issn=09209964&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-02-14 N1 - Date created - 2005-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Polymorphisms of the Toll-Like Receptors and Human Disease AN - 17080627; 6707956 AB - The Toll-like receptor (TLR) family regulates both innate and adaptive immune responses. Given its broad effect on immunity, the function of TLRs in various human diseases has been investigated largely by comparing the incidence of disease among persons with different polymorphisms in the genes that participate in TLR signaling. These studies demonstrate that TLR function affects several diseases, including sepsis, immunodeficiencies, atherosclerosis, and asthma. These findings have resulted in new opportunities to study the pathogenesis of disease, identify subpopulations at greater risk of disease, and, potentially, identify novel therapeutic approaches. JF - Clinical Infectious Diseases AU - Schwartz, DA AU - Cook, D N AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA Y1 - 2005/11/15/ PY - 2005 DA - 2005 Nov 15 SP - S403 EP - S407 VL - 41 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Risk assessment KW - Sepsis KW - Gene polymorphism KW - Subpopulations KW - Immunodeficiency KW - Asthma KW - Arteriosclerosis KW - Immunity KW - Immune response KW - Toll-like receptors KW - Signal transduction KW - J 02350:Immunology KW - F 06950:Immunogenetics, MHC, HLA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17080627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Polymorphisms+of+the+Toll-Like+Receptors+and+Human+Disease&rft.au=Schwartz%2C+DA%3BCook%2C+D+N&rft.aulast=Schwartz&rft.aufirst=DA&rft.date=2005-11-15&rft.volume=41&rft.issue=&rft.spage=S403&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Risk assessment; Sepsis; Subpopulations; Gene polymorphism; Immunodeficiency; Asthma; Immune response; Immunity; Arteriosclerosis; Toll-like receptors; Signal transduction ER - TY - CPAPER T1 - Live Cell-Based Assays for Compound Screening T2 - Second Annual Conference on Fluorescent Proteins for Cellular Imaging and Drug Development AN - 40129077; 4041394 JF - Second Annual Conference on Fluorescent Proteins for Cellular Imaging and Drug Development AU - Inglese, James Y1 - 2005/11/14/ PY - 2005 DA - 2005 Nov 14 KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40129077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+Annual+Conference+on+Fluorescent+Proteins+for+Cellular+Imaging+and+Drug+Development&rft.atitle=Live+Cell-Based+Assays+for+Compound+Screening&rft.au=Inglese%2C+James&rft.aulast=Inglese&rft.aufirst=James&rft.date=2005-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+Annual+Conference+on+Fluorescent+Proteins+for+Cellular+Imaging+and+Drug+Development&rft.issn=&rft_id=info:doi/ L2 - http://www.healthtech.com/2005/gfp/index.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Frontiers in Fluorescent Protein Imaging in Living Cells T2 - Second Annual Conference on Fluorescent Proteins for Cellular Imaging and Drug Development AN - 40110722; 4041388 JF - Second Annual Conference on Fluorescent Proteins for Cellular Imaging and Drug Development AU - Patterson, George Y1 - 2005/11/14/ PY - 2005 DA - 2005 Nov 14 KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40110722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+Annual+Conference+on+Fluorescent+Proteins+for+Cellular+Imaging+and+Drug+Development&rft.atitle=Frontiers+in+Fluorescent+Protein+Imaging+in+Living+Cells&rft.au=Patterson%2C+George&rft.aulast=Patterson&rft.aufirst=George&rft.date=2005-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+Annual+Conference+on+Fluorescent+Proteins+for+Cellular+Imaging+and+Drug+Development&rft.issn=&rft_id=info:doi/ L2 - http://www.healthtech.com/2005/gfp/index.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis and Application of RNAi against Cancer Associated Genes T2 - AACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications AN - 40055475; 4016049 JF - AACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications AU - Caplen, Natasha Y1 - 2005/11/14/ PY - 2005 DA - 2005 Nov 14 KW - RNA-mediated interference KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40055475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=AACR-NCI-EORTC+Conference+on+Molecular+Targets+and+Cancer+Therapeutics%3A+Discovery%2C+Biology%2C+and+Clinical+Applications&rft.atitle=Analysis+and+Application+of+RNAi+against+Cancer+Associated+Genes&rft.au=Caplen%2C+Natasha&rft.aulast=Caplen&rft.aufirst=Natasha&rft.date=2005-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=AACR-NCI-EORTC+Conference+on+Molecular+Targets+and+Cancer+Therapeutics%3A+Discovery%2C+Biology%2C+and+Clinical+Applications&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/page4277.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preclinical Development of Halichondrin B and its Derivative Eisai E7389 T2 - AACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications AN - 40051612; 4016006 JF - AACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications AU - Newman, D J Y1 - 2005/11/14/ PY - 2005 DA - 2005 Nov 14 KW - Drug discovery KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40051612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=AACR-NCI-EORTC+Conference+on+Molecular+Targets+and+Cancer+Therapeutics%3A+Discovery%2C+Biology%2C+and+Clinical+Applications&rft.atitle=Preclinical+Development+of+Halichondrin+B+and+its+Derivative+Eisai+E7389&rft.au=Newman%2C+D+J&rft.aulast=Newman&rft.aufirst=D&rft.date=2005-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=AACR-NCI-EORTC+Conference+on+Molecular+Targets+and+Cancer+Therapeutics%3A+Discovery%2C+Biology%2C+and+Clinical+Applications&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/page4277.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MMP2 Activates TGF-ss1 and Augments TssRII Signaling within the Aged Arterial Wall: Relevance to Matrix Deposition with Aging T2 - 2005 Scientific Sessions of the American Heart Association AN - 40004478; 4110583 JF - 2005 Scientific Sessions of the American Heart Association AU - Wang, Mingyi AU - Zhao, Di AU - Spinetti, Gaia AU - Zhang, Jing AU - Jiang, Li-Qun AU - Pintus, Gianfranco AU - Monticone, Robert E AU - Lakatta, Edward G Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Aging KW - Signal transduction KW - Gelatinase A KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40004478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=MMP2+Activates+TGF-ss1+and+Augments+TssRII+Signaling+within+the+Aged+Arterial+Wall%3A+Relevance+to+Matrix+Deposition+with+Aging&rft.au=Wang%2C+Mingyi%3BZhao%2C+Di%3BSpinetti%2C+Gaia%3BZhang%2C+Jing%3BJiang%2C+Li-Qun%3BPintus%2C+Gianfranco%3BMonticone%2C+Robert+E%3BLakatta%2C+Edward+G&rft.aulast=Wang&rft.aufirst=Mingyi&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Indices of Ventricular Relaxation are Not Related to Objective Measures of Exercise Capacity in Non-Obstructive Hypertrophic Cardiomyopathy T2 - 2005 Scientific Sessions of the American Heart Association AN - 39960896; 4109006 JF - 2005 Scientific Sessions of the American Heart Association AU - Owens, David S AU - Arena, Ross A AU - Smith, Kevin AU - Mohiddin, Saidi A AU - McAreavey, Dorothea AU - Bacharach, Steve L AU - Ulisney, Karen L AU - Fananapazir, Lameh AU - Hadi, Mohiuddin AU - Plehn, Jonathan F Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Cardiomyopathy KW - Physical training KW - Circulatory system KW - Heart KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39960896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Indices+of+Ventricular+Relaxation+are+Not+Related+to+Objective+Measures+of+Exercise+Capacity+in+Non-Obstructive+Hypertrophic+Cardiomyopathy&rft.au=Owens%2C+David+S%3BArena%2C+Ross+A%3BSmith%2C+Kevin%3BMohiddin%2C+Saidi+A%3BMcAreavey%2C+Dorothea%3BBacharach%2C+Steve+L%3BUlisney%2C+Karen+L%3BFananapazir%2C+Lameh%3BHadi%2C+Mohiuddin%3BPlehn%2C+Jonathan+F&rft.aulast=Owens&rft.aufirst=David&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tnf Receptor-Associated Factor 2 (TRAF2) is an Important Adaptor in Activation of Nuclear Factor (NF-KB) and Activation Protein (AP-1) Pathways in Human B Cells T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39960211; 4104232 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Martins, Diana C AU - Zhang, Wen AU - Zhang, Xuan AU - He, Liusheng AU - Lipsky, Peter E AU - Grammer, Amrie C Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Cell activation KW - Lymphocytes B KW - Tumor necrosis factor KW - NF-^KB protein KW - TRAF2 protein KW - Adaptor proteins KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39960211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Tnf+Receptor-Associated+Factor+2+%28TRAF2%29+is+an+Important+Adaptor+in+Activation+of+Nuclear+Factor+%28NF-KB%29+and+Activation+Protein+%28AP-1%29+Pathways+in+Human+B+Cells&rft.au=Martins%2C+Diana+C%3BZhang%2C+Wen%3BZhang%2C+Xuan%3BHe%2C+Liusheng%3BLipsky%2C+Peter+E%3BGrammer%2C+Amrie+C&rft.aulast=Martins&rft.aufirst=Diana&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bone Density and Metabolism in Patients with NOMID after 12 Months of Treatment with the IL-1 Receptor-Antagonist Anakinra/kineretRG T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39944745; 4103101 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Canna, S AU - Gelabert, A AU - Jones, J AU - Dailey, N J AU - Kastner, D AU - Reynolds, J AU - Goldbach-Mansky, R Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Bone density KW - Metabolism KW - Interleukin 1 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39944745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Bone+Density+and+Metabolism+in+Patients+with+NOMID+after+12+Months+of+Treatment+with+the+IL-1+Receptor-Antagonist+Anakinra%2FkineretRG&rft.au=Canna%2C+S%3BGelabert%2C+A%3BJones%2C+J%3BDailey%2C+N+J%3BKastner%2C+D%3BReynolds%2C+J%3BGoldbach-Mansky%2C+R&rft.aulast=Canna&rft.aufirst=S&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impact of Rheumatoid Arthritis (RA) Core Set Measures on Rheumatologists Judgment of Disease Activity T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39941991; 4103343 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Aletaha, Daniel AU - Machold, Klaus P AU - Nell, Valerie P.K. AU - Smolen, Josef S Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Cores KW - Rheumatoid arthritis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39941991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Impact+of+Rheumatoid+Arthritis+%28RA%29+Core+Set+Measures+on+Rheumatologists+Judgment+of+Disease+Activity&rft.au=Aletaha%2C+Daniel%3BMachold%2C+Klaus+P%3BNell%2C+Valerie+P.K.%3BSmolen%2C+Josef+S&rft.aulast=Aletaha&rft.aufirst=Daniel&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Prevalence of Infarct and Non-Infarct as the Etiology in Impaired Left Ventricular Systolic Function in the Elderly: A Gadolinium Enhanced Cardiac MRI Study T2 - 2005 Scientific Sessions of the American Heart Association AN - 39908609; 4108648 JF - 2005 Scientific Sessions of the American Heart Association AU - Cao, Jie J AU - Sigurdsson, Sigurdur AU - Vincent, Pamela AU - Padmanabhan, Sriram AU - Holly, Jessica AU - Launer, Lenore AU - Aletras, Anthony H AU - Eiriksdottir, Gudny AU - Thorgeirsson, Gudmundur AU - Aspelund, Thor AU - Gudnason, Vilmundur AU - Harris, Tamara AU - Arai, Andrew E Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Gadolinium KW - Elderly KW - Etiology KW - Magnetic resonance imaging KW - Heart KW - Geriatrics KW - Aetiology KW - Circulatory system KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39908609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=The+Prevalence+of+Infarct+and+Non-Infarct+as+the+Etiology+in+Impaired+Left+Ventricular+Systolic+Function+in+the+Elderly%3A+A+Gadolinium+Enhanced+Cardiac+MRI+Study&rft.au=Cao%2C+Jie+J%3BSigurdsson%2C+Sigurdur%3BVincent%2C+Pamela%3BPadmanabhan%2C+Sriram%3BHolly%2C+Jessica%3BLauner%2C+Lenore%3BAletras%2C+Anthony+H%3BEiriksdottir%2C+Gudny%3BThorgeirsson%2C+Gudmundur%3BAspelund%2C+Thor%3BGudnason%2C+Vilmundur%3BHarris%2C+Tamara%3BArai%2C+Andrew+E&rft.aulast=Cao&rft.aufirst=Jie&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Heterogeneous Skeletal Muscle Perfusion Recovery after Stenting: Insight into Regional Ischemic Blood Flow Control T2 - 2005 Scientific Sessions of the American Heart Association AN - 39907826; 4107904 JF - 2005 Scientific Sessions of the American Heart Association AU - Aviles, Ronnier J AU - Thompson, Richard B AU - Ozturk, Cengizhan AU - Raval, Amish N AU - DeSilva, Ranil AU - Stine, Annette AU - Wright, Victor AU - Raman, Venkatesh K AU - Balaban, Robert S AU - Lederman, Robert J Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Blood circulation KW - Ischemia KW - Perfusion KW - Skeletal muscle KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39907826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Heterogeneous+Skeletal+Muscle+Perfusion+Recovery+after+Stenting%3A+Insight+into+Regional+Ischemic+Blood+Flow+Control&rft.au=Aviles%2C+Ronnier+J%3BThompson%2C+Richard+B%3BOzturk%2C+Cengizhan%3BRaval%2C+Amish+N%3BDeSilva%2C+Ranil%3BStine%2C+Annette%3BWright%2C+Victor%3BRaman%2C+Venkatesh+K%3BBalaban%2C+Robert+S%3BLederman%2C+Robert+J&rft.aulast=Aviles&rft.aufirst=Ronnier&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Contribution of Hepatic and Extrahepatic ABCA1 to Plasma HDL-C and ApoB-Containing Lipoprotein Cholesterol in Transgenic Mice T2 - 2005 Scientific Sessions of the American Heart Association AN - 39892224; 4110770 JF - 2005 Scientific Sessions of the American Heart Association AU - Liu, Lijuan AU - Joyce, Charles AU - Vaisman, Boris AU - Basso, Federica AU - Amar, Marcelo J A AU - Shamburek, Robert D AU - Santamarina-Fojo, Silvia Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Mice KW - Lipoproteins KW - Cholesterol KW - Liver KW - Transgenic mice KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39892224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Contribution+of+Hepatic+and+Extrahepatic+ABCA1+to+Plasma+HDL-C+and+ApoB-Containing+Lipoprotein+Cholesterol+in+Transgenic+Mice&rft.au=Liu%2C+Lijuan%3BJoyce%2C+Charles%3BVaisman%2C+Boris%3BBasso%2C+Federica%3BAmar%2C+Marcelo+J+A%3BShamburek%2C+Robert+D%3BSantamarina-Fojo%2C+Silvia&rft.aulast=Liu&rft.aufirst=Lijuan&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Simple and Rapid Quantification of Mechanical Dyssynchrony for Cardiac Resynchronization Therapy T2 - 2005 Scientific Sessions of the American Heart Association AN - 39885360; 4109192 JF - 2005 Scientific Sessions of the American Heart Association AU - Ashikaga, Hiroshi AU - Kellman, Peter AU - Mickelsen, Steven R AU - McVeigh, Elliot R Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Heart KW - Therapy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39885360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Simple+and+Rapid+Quantification+of+Mechanical+Dyssynchrony+for+Cardiac+Resynchronization+Therapy&rft.au=Ashikaga%2C+Hiroshi%3BKellman%2C+Peter%3BMickelsen%2C+Steven+R%3BMcVeigh%2C+Elliot+R&rft.aulast=Ashikaga&rft.aufirst=Hiroshi&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microalbuminuria and the Risk of Cardiovascular Events and All-Cause Mortality in the Elderly, the Cardiovascular Health Study T2 - 2005 Scientific Sessions of the American Heart Association AN - 39884722; 4108306 JF - 2005 Scientific Sessions of the American Heart Association AU - Cao, Jie J AU - Biggs, Mary L AU - Barzilay, Joshua AU - Konen, Joseph AU - Psaty, Bruce M AU - Kuller, Lewis AU - Bleyer, Anthony J AU - Olson, Jean AU - Wexler, Jason AU - Summerson, John AU - Cushman, Mary Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Elderly KW - Mortality KW - Geriatrics KW - Cardiovascular diseases KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39884722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Microalbuminuria+and+the+Risk+of+Cardiovascular+Events+and+All-Cause+Mortality+in+the+Elderly%2C+the+Cardiovascular+Health+Study&rft.au=Cao%2C+Jie+J%3BBiggs%2C+Mary+L%3BBarzilay%2C+Joshua%3BKonen%2C+Joseph%3BPsaty%2C+Bruce+M%3BKuller%2C+Lewis%3BBleyer%2C+Anthony+J%3BOlson%2C+Jean%3BWexler%2C+Jason%3BSummerson%2C+John%3BCushman%2C+Mary&rft.aulast=Cao&rft.aufirst=Jie&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An SLE-Associated Mutation in CD40 Alters Human B Cell Function T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39883841; 4104233 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Zhang, Wen AU - Fischer, Randy AU - He, Luisheng AU - Pisitkun, Prapaporn AU - Gaffney, P AU - Behrens, T AU - Lipsky, Peter E AU - Grammer, Amrie C Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Mutation KW - CD40 antigen KW - Lymphocytes B KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39883841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=An+SLE-Associated+Mutation+in+CD40+Alters+Human+B+Cell+Function&rft.au=Zhang%2C+Wen%3BFischer%2C+Randy%3BHe%2C+Luisheng%3BPisitkun%2C+Prapaporn%3BGaffney%2C+P%3BBehrens%2C+T%3BLipsky%2C+Peter+E%3BGrammer%2C+Amrie+C&rft.aulast=Zhang&rft.aufirst=Wen&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression, Phenotypic and Proteomic Profile of Ig-Secreting Plasma Cells in the Periphery of Patients with Active Sle T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39880237; 4104228 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Lugar, Patricia AU - Slota, Rebecca AU - Fischer, Randy AU - Phillips, Terry AU - Brescia, AnneMarie AU - Lipsky, Peter AU - Grammer, Amrie C Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Gene expression KW - Plasma cells KW - Proteomics KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39880237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Gene+Expression%2C+Phenotypic+and+Proteomic+Profile+of+Ig-Secreting+Plasma+Cells+in+the+Periphery+of+Patients+with+Active+Sle&rft.au=Lugar%2C+Patricia%3BSlota%2C+Rebecca%3BFischer%2C+Randy%3BPhillips%2C+Terry%3BBrescia%2C+AnneMarie%3BLipsky%2C+Peter%3BGrammer%2C+Amrie+C&rft.aulast=Lugar&rft.aufirst=Patricia&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Performance-Based Assessment of Functional Limitation and Muscle Endurance: Reliability of the Adult Myositis Assessment Tool T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39877001; 4103852 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Harris-Love, Michael AU - Joe, Galen AU - Abbett, Kristen AU - Koziol, Dee Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Muscles KW - Myositis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39877001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Performance-Based+Assessment+of+Functional+Limitation+and+Muscle+Endurance%3A+Reliability+of+the+Adult+Myositis+Assessment+Tool&rft.au=Harris-Love%2C+Michael%3BJoe%2C+Galen%3BAbbett%2C+Kristen%3BKoziol%2C+Dee&rft.aulast=Harris-Love&rft.aufirst=Michael&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Amplified Profiling of Platelet Transcriptome in Sickle Cell Disease Reveals Global Activation and Dysregulated Arginine Processing T2 - 2005 Scientific Sessions of the American Heart Association AN - 39876908; 4110543 JF - 2005 Scientific Sessions of the American Heart Association AU - Raghahavachari, Nalini AU - Villagra, Jose AU - Harris, Amy AU - Logun, Carolea AU - Xu, Xiuli AU - Munson, Peter AU - Kato, Gregory AU - Solomon, Michael A AU - Danner, Robert A AU - Gladwin, Mark T Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Platelets KW - Sickle cell disease KW - Arginine KW - Profiling KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39876908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Amplified+Profiling+of+Platelet+Transcriptome+in+Sickle+Cell+Disease+Reveals+Global+Activation+and+Dysregulated+Arginine+Processing&rft.au=Raghahavachari%2C+Nalini%3BVillagra%2C+Jose%3BHarris%2C+Amy%3BLogun%2C+Carolea%3BXu%2C+Xiuli%3BMunson%2C+Peter%3BKato%2C+Gregory%3BSolomon%2C+Michael+A%3BDanner%2C+Robert+A%3BGladwin%2C+Mark+T&rft.aulast=Raghahavachari&rft.aufirst=Nalini&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inducible Mitochondrial Uncoupling - An Endogenous Regulatory Mechanism Augmenting Tolerance to Cardiac Ischemia T2 - 2005 Scientific Sessions of the American Heart Association AN - 39875551; 4109711 JF - 2005 Scientific Sessions of the American Heart Association AU - McLeod, Christopher J AU - McCoy Jr, J Philip AU - Aziz, Abdulhameed AU - Sack, Michael N Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Ischemia KW - Mitochondria KW - Heart KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39875551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Inducible+Mitochondrial+Uncoupling+-+An+Endogenous+Regulatory+Mechanism+Augmenting+Tolerance+to+Cardiac+Ischemia&rft.au=McLeod%2C+Christopher+J%3BMcCoy+Jr%2C+J+Philip%3BAziz%2C+Abdulhameed%3BSack%2C+Michael+N&rft.aulast=McLeod&rft.aufirst=Christopher&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Specific Occupational Activities Associated with Functional Limitations in Patients with Long-Standing Ankylosing Spondylitis T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39875424; 4103603 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Ward, Michael M AU - Reveille, John D AU - Davis, John C AU - Weisman, Michael Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Ankylosing spondylitis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39875424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Specific+Occupational+Activities+Associated+with+Functional+Limitations+in+Patients+with+Long-Standing+Ankylosing+Spondylitis&rft.au=Ward%2C+Michael+M%3BReveille%2C+John+D%3BDavis%2C+John+C%3BWeisman%2C+Michael&rft.aulast=Ward&rft.aufirst=Michael&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Met66 Variant of the Functional Val66Met Polymorphism in the Brain-Derived Neurotrophic Factor Gene Confers Protection against Cognitive Dysfunction in Systemic Lupus Erythematosus (SLE) T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39869735; 4103569 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Lapteva, Larissa AU - Oroszi, Gabor AU - Davis, Elizabeth AU - Yarboro, Cheryl H AU - Lipsky, Peter E AU - Goldman, David AU - Hu, Xian-Zhang AU - Lipsky, Robert AU - Illei, Gabor G Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Systemic lupus erythematosus KW - Gene polymorphism KW - Brain-derived neurotrophic factor KW - Cognitive ability KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39869735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=The+Met66+Variant+of+the+Functional+Val66Met+Polymorphism+in+the+Brain-Derived+Neurotrophic+Factor+Gene+Confers+Protection+against+Cognitive+Dysfunction+in+Systemic+Lupus+Erythematosus+%28SLE%29&rft.au=Lapteva%2C+Larissa%3BOroszi%2C+Gabor%3BDavis%2C+Elizabeth%3BYarboro%2C+Cheryl+H%3BLipsky%2C+Peter+E%3BGoldman%2C+David%3BHu%2C+Xian-Zhang%3BLipsky%2C+Robert%3BIllei%2C+Gabor+G&rft.aulast=Lapteva&rft.aufirst=Larissa&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Impact of In Vivo Anti IL-6 Receptor Blockade on Circulating T and B Cell Subsets in Patients with Systemic Lupus Erythematosus T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39869133; 4103159 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Shirota, Yuko AU - Yarboro, Cheryl AU - Sims, Gary AU - Fritsch, Ruth AU - Ettinger, Rachel AU - Valencia, Xavier AU - Fischer, Randy AU - Grammer, Amrie AU - Pham, Tuyet-Hang AU - Lipsky, Peter E AU - Illei, Gabor G Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Lymphocytes B KW - Systemic lupus erythematosus KW - Interleukin 6 receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39869133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=The+Impact+of+In+Vivo+Anti+IL-6+Receptor+Blockade+on+Circulating+T+and+B+Cell+Subsets+in+Patients+with+Systemic+Lupus+Erythematosus&rft.au=Shirota%2C+Yuko%3BYarboro%2C+Cheryl%3BSims%2C+Gary%3BFritsch%2C+Ruth%3BEttinger%2C+Rachel%3BValencia%2C+Xavier%3BFischer%2C+Randy%3BGrammer%2C+Amrie%3BPham%2C+Tuyet-Hang%3BLipsky%2C+Peter+E%3BIllei%2C+Gabor+G&rft.aulast=Shirota&rft.aufirst=Yuko&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Contribution of Nitric Oxide to Endothelial Progenitor Cell Mobilization, Survival and Differentiation Potential in Patients with Coronary Artery Disease Undergoing Cardiac Rehabilitation T2 - 2005 Scientific Sessions of the American Heart Association AN - 39865050; 4110264 JF - 2005 Scientific Sessions of the American Heart Association AU - Rodrigo, Maria E AU - Benjamin, Moshe AU - Carlow, Andrea AU - Annavajjhala, Vidhya AU - Dejam, Andre AU - Paul, Jonathan D AU - Powell, Tiffany M AU - Thompson, Michael AU - McCoy, J Philip AU - Zalos, Gloria AU - Murphy, Mandy AU - Hill, Jonathan M AU - Gladwin, Mark AU - Orlic, Donald AU - Cannon III, Richard O Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Nitric oxide KW - Heart diseases KW - Coronary heart disease KW - Differentiation KW - Rehabilitation KW - Cell survival KW - Stem cells KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39865050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Contribution+of+Nitric+Oxide+to+Endothelial+Progenitor+Cell+Mobilization%2C+Survival+and+Differentiation+Potential+in+Patients+with+Coronary+Artery+Disease+Undergoing+Cardiac+Rehabilitation&rft.au=Rodrigo%2C+Maria+E%3BBenjamin%2C+Moshe%3BCarlow%2C+Andrea%3BAnnavajjhala%2C+Vidhya%3BDejam%2C+Andre%3BPaul%2C+Jonathan+D%3BPowell%2C+Tiffany+M%3BThompson%2C+Michael%3BMcCoy%2C+J+Philip%3BZalos%2C+Gloria%3BMurphy%2C+Mandy%3BHill%2C+Jonathan+M%3BGladwin%2C+Mark%3BOrlic%2C+Donald%3BCannon+III%2C+Richard+O&rft.aulast=Rodrigo&rft.aufirst=Maria&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - S-Nitrosylation of the L-type Ca@@u2+@ Channel is Involved in Cardioprotection in Female Hearts T2 - 2005 Scientific Sessions of the American Heart Association AN - 39863819; 4107206 JF - 2005 Scientific Sessions of the American Heart Association AU - Sun, Junhui AU - Picht, Eckard AU - Bers, Donald AU - Steenbergen, Charles AU - Murphy, Elizabeth Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Calcium channels (L-type) KW - Heart KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39863819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=S-Nitrosylation+of+the+L-type+Ca%40%40u2%2B%40+Channel+is+Involved+in+Cardioprotection+in+Female+Hearts&rft.au=Sun%2C+Junhui%3BPicht%2C+Eckard%3BBers%2C+Donald%3BSteenbergen%2C+Charles%3BMurphy%2C+Elizabeth&rft.aulast=Sun&rft.aufirst=Junhui&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Accuracy of Glomerular Filtration Rate (GFR) Prediction Equations in Patients with Immune-Mediated Glomerulonephritides (GN) T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39860142; 4104083 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Illei, Gabor G AU - Jacobs, Geneva AU - Austin, Howard AU - Ward, Michael Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Filtration KW - Glomerular filtration rate KW - Mathematical models KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39860142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Accuracy+of+Glomerular+Filtration+Rate+%28GFR%29+Prediction+Equations+in+Patients+with+Immune-Mediated+Glomerulonephritides+%28GN%29&rft.au=Illei%2C+Gabor+G%3BJacobs%2C+Geneva%3BAustin%2C+Howard%3BWard%2C+Michael&rft.aulast=Illei&rft.aufirst=Gabor&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Trends in Diabetes as a Cardiovascular Disease Risk Factor: the Framingham Heart Study T2 - 2005 Scientific Sessions of the American Heart Association AN - 39857965; 4108325 JF - 2005 Scientific Sessions of the American Heart Association AU - Fox, Caroline S AU - Coady, Sean AU - Sorlie, Paul D AU - D'Agostino Sr, Ralph B AU - Vasan, Ramachandran S AU - Meigs, James B AU - Levy, Daniel AU - Savage, Peter J Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Cardiovascular diseases KW - Risk factors KW - Diabetes mellitus KW - Heart KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39857965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Trends+in+Diabetes+as+a+Cardiovascular+Disease+Risk+Factor%3A+the+Framingham+Heart+Study&rft.au=Fox%2C+Caroline+S%3BCoady%2C+Sean%3BSorlie%2C+Paul+D%3BD%27Agostino+Sr%2C+Ralph+B%3BVasan%2C+Ramachandran+S%3BMeigs%2C+James+B%3BLevy%2C+Daniel%3BSavage%2C+Peter+J&rft.aulast=Fox&rft.aufirst=Caroline&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Myeloperoxidase (MPO) Modulates Risk for Developing Congestive Heart Failure (CHF) T2 - 2005 Scientific Sessions of the American Heart Association AN - 39852900; 4109162 JF - 2005 Scientific Sessions of the American Heart Association AU - Aviles, Ronnier J AU - Brennan, Marie-Luise AU - Mann, Shirley AU - Tracy, Russell P AU - Psaty, Bruce M AU - Hazen, Stanley L Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Congestive heart failure KW - Risk factors KW - Peroxidase KW - Heart KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39852900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Myeloperoxidase+%28MPO%29+Modulates+Risk+for+Developing+Congestive+Heart+Failure+%28CHF%29&rft.au=Aviles%2C+Ronnier+J%3BBrennan%2C+Marie-Luise%3BMann%2C+Shirley%3BTracy%2C+Russell+P%3BPsaty%2C+Bruce+M%3BHazen%2C+Stanley+L&rft.aulast=Aviles&rft.aufirst=Ronnier&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ABCG1-Modifed Plasma Membrane Lipid Domains Mediate Cellular Cholesterol Efflux to HDL T2 - 2005 Scientific Sessions of the American Heart Association AN - 39850818; 4110632 JF - 2005 Scientific Sessions of the American Heart Association AU - Neufeld, Edward B AU - O'Brien, Katherine G AU - Demosky Jr, Stephen J AU - Stonik, John A AU - Sabol, Steven L AU - Malide, Daniela AU - Combs, Christian A AU - Remaley, Alan T AU - Santamarina-Fojo, Silvia AU - Brewer Jr, H Bryan Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Lipid rafts KW - Plasma membranes KW - Cholesterol KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39850818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=ABCG1-Modifed+Plasma+Membrane+Lipid+Domains+Mediate+Cellular+Cholesterol+Efflux+to+HDL&rft.au=Neufeld%2C+Edward+B%3BO%27Brien%2C+Katherine+G%3BDemosky+Jr%2C+Stephen+J%3BStonik%2C+John+A%3BSabol%2C+Steven+L%3BMalide%2C+Daniela%3BCombs%2C+Christian+A%3BRemaley%2C+Alan+T%3BSantamarina-Fojo%2C+Silvia%3BBrewer+Jr%2C+H+Bryan&rft.aulast=Neufeld&rft.aufirst=Edward&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Validity of the Myositis Disease Activity Assessment Tool (MDAAT) for Assessing Extra-Muscular Disease Activity in Adult and Juvenile Idiopathic Inflammatory Myopathies (IIM) T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39848655; 4103891 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Rider, Lisa AU - Villalba, Maria AU - Adams, Elizabeth AU - Joe, Galen AU - Harris-Love, Michael AU - Hill, Suvimol AU - James-Newton, Laura AU - Hicks, Jeanne AU - Plotz, Paul AU - Lachenbruch, Peter AU - Miller, Frederick Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Myositis KW - Inflammation KW - Myopathy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39848655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Validity+of+the+Myositis+Disease+Activity+Assessment+Tool+%28MDAAT%29+for+Assessing+Extra-Muscular+Disease+Activity+in+Adult+and+Juvenile+Idiopathic+Inflammatory+Myopathies+%28IIM%29&rft.au=Rider%2C+Lisa%3BVillalba%2C+Maria%3BAdams%2C+Elizabeth%3BJoe%2C+Galen%3BHarris-Love%2C+Michael%3BHill%2C+Suvimol%3BJames-Newton%2C+Laura%3BHicks%2C+Jeanne%3BPlotz%2C+Paul%3BLachenbruch%2C+Peter%3BMiller%2C+Frederick&rft.aulast=Rider&rft.aufirst=Lisa&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Treatment of 4 Patients with Cryopyrin-Associated Periodic Syndromes with the Long-Acting Il-1 Inhibitor Il-1 Trap T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39846580; 4102932 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Canna, S AU - Gelabert, A AU - Aksentijevich, I AU - Mellis, S AU - Radin, A AU - Papadopoulos, J AU - Barham, B AU - Wilson, M AU - Hawkins, P AU - Kastner, D AU - Goldbach-Mansky, R Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Interleukin 1 KW - Inhibitors KW - Symptoms KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39846580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Treatment+of+4+Patients+with+Cryopyrin-Associated+Periodic+Syndromes+with+the+Long-Acting+Il-1+Inhibitor+Il-1+Trap&rft.au=Canna%2C+S%3BGelabert%2C+A%3BAksentijevich%2C+I%3BMellis%2C+S%3BRadin%2C+A%3BPapadopoulos%2C+J%3BBarham%2C+B%3BWilson%2C+M%3BHawkins%2C+P%3BKastner%2C+D%3BGoldbach-Mansky%2C+R&rft.aulast=Canna&rft.aufirst=S&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Seasonal Birth Patterns in Subgroups of Myositis Suggest a Role for Perinatal Environmental Factors in Etiology T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39845595; 4103649 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Vegosen, Leora AU - Weinberg, Clarice AU - O'Hanlon, Terrance AU - Targoff, Ira AU - Koneru, Bhanu AU - Mamyrova, Gulnara AU - Miller, Frederick AU - Rider, Lisa Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Seasonal variations KW - Etiology KW - Sulfur dioxide KW - Myositis KW - Birth KW - Environmental factors KW - Aetiology KW - Parturition KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39845595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Seasonal+Birth+Patterns+in+Subgroups+of+Myositis+Suggest+a+Role+for+Perinatal+Environmental+Factors+in+Etiology&rft.au=Vegosen%2C+Leora%3BWeinberg%2C+Clarice%3BO%27Hanlon%2C+Terrance%3BTargoff%2C+Ira%3BKoneru%2C+Bhanu%3BMamyrova%2C+Gulnara%3BMiller%2C+Frederick%3BRider%2C+Lisa&rft.aulast=Vegosen&rft.aufirst=Leora&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Multiple Serum Cytokines and Chemokines in SLE Patients Demonstrates that They Highly Correlate to Each Other and Fails to Identify a Principal Effector Molecule T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39844877; 4103585 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Illei, Gabor G AU - Phillips, Terry M AU - Yarboro, Cheryl AU - Pham, Tuyet-Hang AU - Sun, Hong-Wei AU - Lipsky, Peter E Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Cytokines KW - Chemokines KW - Serum KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39844877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Analysis+of+Multiple+Serum+Cytokines+and+Chemokines+in+SLE+Patients+Demonstrates+that+They+Highly+Correlate+to+Each+Other+and+Fails+to+Identify+a+Principal+Effector+Molecule&rft.au=Illei%2C+Gabor+G%3BPhillips%2C+Terry+M%3BYarboro%2C+Cheryl%3BPham%2C+Tuyet-Hang%3BSun%2C+Hong-Wei%3BLipsky%2C+Peter+E&rft.aulast=Illei&rft.aufirst=Gabor&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Defective Suppressor Function of CD4+CD25hi T Regulatory Cells in Active SLE T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39842472; 4104666 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Valencia, Xavier AU - Vogt, Samantha L AU - Simone, James AU - Yarboro, Cheryl AU - Illei, Gabor AU - Lipsky, Peter E Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Lymphocytes T KW - Immunoregulation KW - Suppressors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39842472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Defective+Suppressor+Function+of+CD4%2BCD25hi+T+Regulatory+Cells+in+Active+SLE&rft.au=Valencia%2C+Xavier%3BVogt%2C+Samantha+L%3BSimone%2C+James%3BYarboro%2C+Cheryl%3BIllei%2C+Gabor%3BLipsky%2C+Peter+E&rft.aulast=Valencia&rft.aufirst=Xavier&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Myocardial Iron Is Not Significantly Abnormal in Patients with Minimally Symptomatic Hereditary Hemochromatosis T2 - 2005 Scientific Sessions of the American Heart Association AN - 39840634; 4108717 JF - 2005 Scientific Sessions of the American Heart Association AU - Padmanabhan, Sriram AU - Shizukuda, Yukitaka AU - Aletras, Anthony H AU - Mordini, Federico AU - Ingkanisorn, W Patricia AU - Cao, Jie AU - Tripodi, Dottie AU - Rosing, Douglas R AU - Bolan, Charles D AU - Leitman, Susan F AU - Arai, Andrew E Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Iron KW - Hemochromatosis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39840634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Myocardial+Iron+Is+Not+Significantly+Abnormal+in+Patients+with+Minimally+Symptomatic+Hereditary+Hemochromatosis&rft.au=Padmanabhan%2C+Sriram%3BShizukuda%2C+Yukitaka%3BAletras%2C+Anthony+H%3BMordini%2C+Federico%3BIngkanisorn%2C+W+Patricia%3BCao%2C+Jie%3BTripodi%2C+Dottie%3BRosing%2C+Douglas+R%3BBolan%2C+Charles+D%3BLeitman%2C+Susan+F%3BArai%2C+Andrew+E&rft.aulast=Padmanabhan&rft.aufirst=Sriram&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Patients' Judgments of Improvement in Rheumatoid Arthritis with ACR and EULAR Response Criteria T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39840550; 4103351 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Ward, Michael M AU - Guthrie, Lori C Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Rheumatoid arthritis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39840550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Comparison+of+Patients%27+Judgments+of+Improvement+in+Rheumatoid+Arthritis+with+ACR+and+EULAR+Response+Criteria&rft.au=Ward%2C+Michael+M%3BGuthrie%2C+Lori+C&rft.aulast=Ward&rft.aufirst=Michael&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Changes in Selected Proteins Associated with Osteoarthritis Development in the Baltimore Longitudinal Study of Aging (BLSA) T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39839031; 4103180 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Ling, Shari M AU - Patel, Dhavalkumar AU - Zhan, Ming AU - Taub, Dennis AU - Muller, Denis AU - Bathon, Joan AU - Hochberg, Marc AU - Abernethy, Darrell AU - Metter, E AU - Ferrucci, Luigi Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - USA, Maryland, Baltimore KW - Aging KW - Osteoarthritis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39839031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Changes+in+Selected+Proteins+Associated+with+Osteoarthritis+Development+in+the+Baltimore+Longitudinal+Study+of+Aging+%28BLSA%29&rft.au=Ling%2C+Shari+M%3BPatel%2C+Dhavalkumar%3BZhan%2C+Ming%3BTaub%2C+Dennis%3BMuller%2C+Denis%3BBathon%2C+Joan%3BHochberg%2C+Marc%3BAbernethy%2C+Darrell%3BMetter%2C+E%3BFerrucci%2C+Luigi&rft.aulast=Ling&rft.aufirst=Shari&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Characteristics of Children with Neonatal Onset Multisystem Inflammatory Disease (NOMID) T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39835976; 4104861 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Canna, Scott AU - Paul, Scott M AU - Hildenbrand, Hanna AU - Jain, Mina AU - Smith, Michaele R AU - Comis, Leora AU - Goldbach-Mansky, Raphaela Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Children KW - Neonates KW - Inflammatory diseases KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39835976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Functional+Characteristics+of+Children+with+Neonatal+Onset+Multisystem+Inflammatory+Disease+%28NOMID%29&rft.au=Canna%2C+Scott%3BPaul%2C+Scott+M%3BHildenbrand%2C+Hanna%3BJain%2C+Mina%3BSmith%2C+Michaele+R%3BComis%2C+Leora%3BGoldbach-Mansky%2C+Raphaela&rft.aulast=Canna&rft.aufirst=Scott&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transcript Profiling of Peripheral Blood Circulating Endothelial Cells T2 - 2005 Scientific Sessions of the American Heart Association AN - 39827602; 4107574 JF - 2005 Scientific Sessions of the American Heart Association AU - Raghavachari, Nalini AU - Khan, Sameena S AU - Elshal, Mohamed AU - Barb, Jennifer AU - Logun, Carolea AU - Munson, Peter J AU - Gladwin, Mark T AU - McCoy, J Philip AU - Danner, Robert L AU - Solomon, Michael A Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Peripheral blood KW - Blood circulation KW - Transcription KW - Endothelial cells KW - Profiling KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39827602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Transcript+Profiling+of+Peripheral+Blood+Circulating+Endothelial+Cells&rft.au=Raghavachari%2C+Nalini%3BKhan%2C+Sameena+S%3BElshal%2C+Mohamed%3BBarb%2C+Jennifer%3BLogun%2C+Carolea%3BMunson%2C+Peter+J%3BGladwin%2C+Mark+T%3BMcCoy%2C+J+Philip%3BDanner%2C+Robert+L%3BSolomon%2C+Michael+A&rft.aulast=Raghavachari&rft.aufirst=Nalini&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ghrelin Improves Endothelial Function in Patients with Metabolic Syndrome T2 - 2005 Scientific Sessions of the American Heart Association AN - 39825983; 4108032 JF - 2005 Scientific Sessions of the American Heart Association AU - Iantorno, Micaela AU - Schinzari, Francesca AU - Tesauro, Manfredi AU - Rizza, Stefano AU - Melina, Domenico AU - Lauro, Davide AU - Cardillo, Carmine Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Ghrelin KW - Symptoms KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39825983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Ghrelin+Improves+Endothelial+Function+in+Patients+with+Metabolic+Syndrome&rft.au=Iantorno%2C+Micaela%3BSchinzari%2C+Francesca%3BTesauro%2C+Manfredi%3BRizza%2C+Stefano%3BMelina%2C+Domenico%3BLauro%2C+Davide%3BCardillo%2C+Carmine&rft.aulast=Iantorno&rft.aufirst=Micaela&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cardiac-Specific Ablation of the Na@@u+@/Ca@@u2+@ Exchanger Confers Protection against Ischemia-Reperfusion Injury T2 - 2005 Scientific Sessions of the American Heart Association AN - 39811868; 4109747 JF - 2005 Scientific Sessions of the American Heart Association AU - Imahashi, Kenichi AU - Steenbergen, Charles AU - Philipson, Kenneth D AU - Murphy, Elizabeth Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Injuries KW - Na@u+/Ca@@u2+@-exchanging ATPase KW - Calcium KW - Ablation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39811868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Cardiac-Specific+Ablation+of+the+Na%40%40u%2B%40%2FCa%40%40u2%2B%40+Exchanger+Confers+Protection+against+Ischemia-Reperfusion+Injury&rft.au=Imahashi%2C+Kenichi%3BSteenbergen%2C+Charles%3BPhilipson%2C+Kenneth+D%3BMurphy%2C+Elizabeth&rft.aulast=Imahashi&rft.aufirst=Kenichi&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DRB1*0301 and the Second Hypervariable Region DRB1 Motif, @@u70@QKRGR@@u74@ are HLA Risk Factors for Dermatomyositis (DM) in African-American (AA) Patients T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39804491; 4103872 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Mamyrova, Gulnara AU - O'Hanlon, Terrance AU - Carrick, Danielle AU - Malley, James AU - Miller, Frederick AU - Rider, Lisa Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Africa KW - Histocompatibility antigen HLA KW - Dermatomyositis KW - Risk factors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39804491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=DRB1*0301+and+the+Second+Hypervariable+Region+DRB1+Motif%2C+%40%40u70%40QKRGR%40%40u74%40+are+HLA+Risk+Factors+for+Dermatomyositis+%28DM%29+in+African-American+%28AA%29+Patients&rft.au=Mamyrova%2C+Gulnara%3BO%27Hanlon%2C+Terrance%3BCarrick%2C+Danielle%3BMalley%2C+James%3BMiller%2C+Frederick%3BRider%2C+Lisa&rft.aulast=Mamyrova&rft.aufirst=Gulnara&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relative Importance of Immunogenetic Risk and Protective Factors for the Development of Juvenile Dermatomyositis (JDM) in European American (EA) Patients T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39801202; 4103873 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Mamyrova, Gulnara AU - Carrick, Danielle AU - O'Hanlon, Terrance AU - Malley, James AU - Reed, Ann AU - Sherry, David AU - Wallace, Carol AU - James-Newton, Laura AU - Zemel, Lawrence AU - Perez, Maria AU - Lindsley, Carol AU - Miller, Frederick AU - Rider, Lisa Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Immunogenetics KW - Dermatomyositis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39801202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Relative+Importance+of+Immunogenetic+Risk+and+Protective+Factors+for+the+Development+of+Juvenile+Dermatomyositis+%28JDM%29+in+European+American+%28EA%29+Patients&rft.au=Mamyrova%2C+Gulnara%3BCarrick%2C+Danielle%3BO%27Hanlon%2C+Terrance%3BMalley%2C+James%3BReed%2C+Ann%3BSherry%2C+David%3BWallace%2C+Carol%3BJames-Newton%2C+Laura%3BZemel%2C+Lawrence%3BPerez%2C+Maria%3BLindsley%2C+Carol%3BMiller%2C+Frederick%3BRider%2C+Lisa&rft.aulast=Mamyrova&rft.aufirst=Gulnara&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Outcomes of Treatment of Neonatal Onset Multisystem Inflammatory Disease (NOMID) with Anakinra: Preliminary Results T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39798493; 4104439 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Paul, Scott M AU - Hildenbrand, Hanna AU - Jain, Mina AU - Smith, Michaele R AU - Canna, Scott AU - Comis, Leora AU - Wiggs, Edith AU - Goldbach-Mansky, Raphaela Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Neonates KW - Inflammatory diseases KW - Disease control KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39798493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Functional+Outcomes+of+Treatment+of+Neonatal+Onset+Multisystem+Inflammatory+Disease+%28NOMID%29+with+Anakinra%3A+Preliminary+Results&rft.au=Paul%2C+Scott+M%3BHildenbrand%2C+Hanna%3BJain%2C+Mina%3BSmith%2C+Michaele+R%3BCanna%2C+Scott%3BComis%2C+Leora%3BWiggs%2C+Edith%3BGoldbach-Mansky%2C+Raphaela&rft.aulast=Paul&rft.aufirst=Scott&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional and Phenotypic Characterization of Anergic B Cells Circulating in the Periphery of Patients with Systemic Lupus Erythematosus T2 - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AN - 39798303; 4103583 JF - 69th Annual Meeting of the American College of Rheumatology and 40th Annual Meeting of the Association of Rheumatology Health Professionals AU - Fischer, Randy T AU - Slota, Rebecca AU - Longo, Nancy AU - Lugar, Patricia AU - Sohn, Hae Won AU - Illei, Gabor AU - Phillips, Terry AU - Lipsky, Peter AU - Grammer, Amrie Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Lymphocytes B KW - Systemic lupus erythematosus KW - Anergy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39798303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.atitle=Functional+and+Phenotypic+Characterization+of+Anergic+B+Cells+Circulating+in+the+Periphery+of+Patients+with+Systemic+Lupus+Erythematosus&rft.au=Fischer%2C+Randy+T%3BSlota%2C+Rebecca%3BLongo%2C+Nancy%3BLugar%2C+Patricia%3BSohn%2C+Hae+Won%3BIllei%2C+Gabor%3BPhillips%2C+Terry%3BLipsky%2C+Peter%3BGrammer%2C+Amrie&rft.aulast=Fischer&rft.aufirst=Randy&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=69th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+40th+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BF5B9F43A%2D 15A0%2D467D%2D8458%2D5DF32518B4E3%7D&AKey=%7BAA45DD66%2DF113%2D4CDD%2D8E62% 2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activation of CaMKII at Mitochondria Triggers Apoptotic Cardiomyocyte Death T2 - 2005 Scientific Sessions of the American Heart Association AN - 39782301; 4109821 JF - 2005 Scientific Sessions of the American Heart Association AU - Zhu, Weizhong AU - yang, Dongmei AU - Crow, Mike T AU - Xiao, Rui-Ping Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - Mortality KW - Apoptosis KW - Cardiomyocytes KW - Mitochondria KW - Ca@@u2+@/calmodulin-dependent protein kinase II KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39782301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Activation+of+CaMKII+at+Mitochondria+Triggers+Apoptotic+Cardiomyocyte+Death&rft.au=Zhu%2C+Weizhong%3Byang%2C+Dongmei%3BCrow%2C+Mike+T%3BXiao%2C+Rui-Ping&rft.aulast=Zhu&rft.aufirst=Weizhong&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2005+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BB72E5685%2D 5345%2D44FD%2DAA31%2DA99FB91EDE85%7D&AKey=%7B2179B014%2DD1C9%2D445E%2D8983% 2D62C46715D639%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Advancing Environmental Toxicogenomics. T2 - 26th Annual Meeting of the Society of Environmental Toxicology and Chemistry AN - 39721616; 4024402 DE: JF - 26th Annual Meeting of the Society of Environmental Toxicology and Chemistry AU - Waters, M Y1 - 2005/11/13/ PY - 2005 DA - 2005 Nov 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39721616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+Society+of+Environmental+Toxicology+and+Chemistry&rft.atitle=Advancing+Environmental+Toxicogenomics.&rft.au=Waters%2C+M&rft.aulast=Waters&rft.aufirst=M&rft.date=2005-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+Society+of+Environmental+Toxicology+and+Chemistry&rft.issn=&rft_id=info:doi/ L2 - http://abstracts.co.allenpress.com/pweb/setac2005/program/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Brainstem Immunoreactivity Response to Chronic Laryngeal Inflammation in the Rat T2 - 35th Annual Meeting of the Society for Neuroscience AN - 40010434; 4132688 JF - 35th Annual Meeting of the Society for Neuroscience AU - Simonyan, K AU - Buckholdt, K AU - Ludlow, C L Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Immunoreactivity KW - Inflammation KW - Brain stem KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40010434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Brainstem+Immunoreactivity+Response+to+Chronic+Laryngeal+Inflammation+in+the+Rat&rft.au=Simonyan%2C+K%3BBuckholdt%2C+K%3BLudlow%2C+C+L&rft.aulast=Simonyan&rft.aufirst=K&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Offspring of VIP/PHI - Deficient Mice Exhibit Developmental Delays T2 - 35th Annual Meeting of the Society for Neuroscience AN - 40003083; 4128515 JF - 35th Annual Meeting of the Society for Neuroscience AU - Cuasay, K AU - May, V AU - Waschek, J A AU - Hill, J M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Offspring KW - Mice KW - Progeny KW - Vasoactive intestinal peptide KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40003083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Offspring+of+VIP%2FPHI+-+Deficient+Mice+Exhibit+Developmental+Delays&rft.au=Cuasay%2C+K%3BMay%2C+V%3BWaschek%2C+J+A%3BHill%2C+J+M&rft.aulast=Cuasay&rft.aufirst=K&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Human Corticospinal Input - output Characteristics Related to Motor Learning and PAS Intervention T2 - 35th Annual Meeting of the Society for Neuroscience AN - 40000535; 4129493 JF - 35th Annual Meeting of the Society for Neuroscience AU - Meunier, S O AU - Russmann, H AU - Hallett, M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Motor skill learning KW - Pyramidal tracts KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40000535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Comparison+of+Human+Corticospinal+Input+-+output+Characteristics+Related+to+Motor+Learning+and+PAS+Intervention&rft.au=Meunier%2C+S+O%3BRussmann%2C+H%3BHallett%2C+M&rft.aulast=Meunier&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of the Hereditary Spastic Paraplegia 3A ( SPG3A ) Protein Atlastin - 1 and Related Family Members T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39998942; 4126440 JF - 35th Annual Meeting of the Society for Neuroscience AU - Soderblom, C AU - Zhu, P AU - Stadler, J AU - Blackstone, C D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Spastic paraplegia KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39998942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Characterization+of+the+Hereditary+Spastic+Paraplegia+3A+%28+SPG3A+%29+Protein+Atlastin+-+1+and+Related+Family+Members&rft.au=Soderblom%2C+C%3BZhu%2C+P%3BStadler%2C+J%3BBlackstone%2C+C+D&rft.aulast=Soderblom&rft.aufirst=C&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distinct NMDA Receptor Subtypes at ON and OFF Inputs to Retinal Ganglion Cells T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39995709; 4127269 JF - 35th Annual Meeting of the Society for Neuroscience AU - Kalbaugh, T L AU - Diamond, J S Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Retinal ganglion cells KW - Glutamic acid receptors KW - N-Methyl-D-aspartic acid receptors KW - Ganglia KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39995709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Distinct+NMDA+Receptor+Subtypes+at+ON+and+OFF+Inputs+to+Retinal+Ganglion+Cells&rft.au=Kalbaugh%2C+T+L%3BDiamond%2C+J+S&rft.aulast=Kalbaugh&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Membrane - Targeting of Phosducin or Phosducin Like - Protein Occludes Voltage - Dependent Inhibition of N - Type Calcium Channels in Rat Superior Cervical Ganglia Neurons T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39995516; 4127253 JF - 35th Annual Meeting of the Society for Neuroscience AU - Partridge, J G AU - Ikeda, S R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Membranes KW - Phosducin KW - Calcium channels KW - Ganglia KW - Calcium channels (voltage-gated) KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39995516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Membrane+-+Targeting+of+Phosducin+or+Phosducin+Like+-+Protein+Occludes+Voltage+-+Dependent+Inhibition+of+N+-+Type+Calcium+Channels+in+Rat+Superior+Cervical+Ganglia+Neurons&rft.au=Partridge%2C+J+G%3BIkeda%2C+S+R&rft.aulast=Partridge&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Isolation and Characterization of an Enriched Preparation of Oligodendrocyte Progenitor Cell Membranes from Rat Cortex T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39993310; 4134345 JF - 35th Annual Meeting of the Society for Neuroscience AU - Weerth, S H AU - Hauser, J AU - Russell, J T Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Cell membranes KW - Glial stem cells KW - Cortex KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39993310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Isolation+and+Characterization+of+an+Enriched+Preparation+of+Oligodendrocyte+Progenitor+Cell+Membranes+from+Rat+Cortex&rft.au=Weerth%2C+S+H%3BHauser%2C+J%3BRussell%2C+J+T&rft.aulast=Weerth&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Social Experience Facilitates Aggression in Mice Lacking a Functional Vasopressin 1b Receptor Gene T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39991386; 4121039 JF - 35th Annual Meeting of the Society for Neuroscience AU - Caldwell, H K AU - Young, W S AU - Wersinger, S R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Mice KW - Aggression KW - Vasopressin KW - Aggressive behaviour KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39991386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Social+Experience+Facilitates+Aggression+in+Mice+Lacking+a+Functional+Vasopressin+1b+Receptor+Gene&rft.au=Caldwell%2C+H+K%3BYoung%2C+W+S%3BWersinger%2C+S+R&rft.aulast=Caldwell&rft.aufirst=H&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuronal Avalanche Dynamics are Independent of Initiating Event Size and Maintain Event Size Memory T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39988805; 4130851 JF - 35th Annual Meeting of the Society for Neuroscience AU - Thiagarajan, T C AU - Plenz, D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Avalanches KW - Memory KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39988805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neuronal+Avalanche+Dynamics+are+Independent+of+Initiating+Event+Size+and+Maintain+Event+Size+Memory&rft.au=Thiagarajan%2C+T+C%3BPlenz%2C+D&rft.aulast=Thiagarajan&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PICK1 is Required for Presynaptic Mossy Fiber - - CA3 Interneuron LTD T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39986171; 4125571 JF - 35th Annual Meeting of the Society for Neuroscience AU - Pelkey, K A AU - Racca, C AU - Takamiya, K AU - Xia, J AU - Huganir, R L AU - McBain, C J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Fibers KW - Long-term depression KW - Interneurons KW - Mossy fibers KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39986171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=PICK1+is+Required+for+Presynaptic+Mossy+Fiber+-+-+CA3+Interneuron+LTD&rft.au=Pelkey%2C+K+A%3BRacca%2C+C%3BTakamiya%2C+K%3BXia%2C+J%3BHuganir%2C+R+L%3BMcBain%2C+C+J&rft.aulast=Pelkey&rft.aufirst=K&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activity - Related Redistribution of Presynaptic Proteins at the Active Zone T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39985713; 4118968 JF - 35th Annual Meeting of the Society for Neuroscience AU - Tao-Cheng, J H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Proteins KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39985713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Activity+-+Related+Redistribution+of+Presynaptic+Proteins+at+the+Active+Zone&rft.au=Tao-Cheng%2C+J+H&rft.aulast=Tao-Cheng&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Cellular Mechanisms for Multiple Time - Scale Adaptation in Cerebellum T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39983780; 4120013 JF - 35th Annual Meeting of the Society for Neuroscience AU - Hong, S Y AU - Optican, L M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Adaptations KW - Cerebellum KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39983780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=New+Cellular+Mechanisms+for+Multiple+Time+-+Scale+Adaptation+in+Cerebellum&rft.au=Hong%2C+S+Y%3BOptican%2C+L+M&rft.aulast=Hong&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Unique Execution of NO - Mediated Toxicity within Naive and NGF - Differentiated PC12 Cells T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39939662; 4134945 JF - 35th Annual Meeting of the Society for Neuroscience AU - Brynczka, C AU - Merrick, B Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Toxicity KW - Pheochromocytoma cells KW - Nerve growth factor KW - Nitric oxide KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39939662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Unique+Execution+of+NO+-+Mediated+Toxicity+within+Naive+and+NGF+-+Differentiated+PC12+Cells&rft.au=Brynczka%2C+C%3BMerrick%2C+B&rft.aulast=Brynczka&rft.aufirst=C&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Self - Renewal of Rat Neural Stem Cells at the Beginning of Cortical Neurogenesis Does Not Require the Contribution of Endogenous Endothelial Cells T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39934827; 4132115 JF - 35th Annual Meeting of the Society for Neuroscience AU - Maric, D AU - Chang, Y H AU - Barker, J L Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Neurogenesis KW - Endothelial cells KW - Neural stem cells KW - Self KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39934827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Self+-+Renewal+of+Rat+Neural+Stem+Cells+at+the+Beginning+of+Cortical+Neurogenesis+Does+Not+Require+the+Contribution+of+Endogenous+Endothelial+Cells&rft.au=Maric%2C+D%3BChang%2C+Y+H%3BBarker%2C+J+L&rft.aulast=Maric&rft.aufirst=D&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enhanced Slow Oscillations in Neuronal Activity of Basal Ganglia Output Nuclei after Dopamine Cell Lesion in Urethane Anesthetized Rats: Exploring Effects on Ventrolateral Thalamus and Motor Cortex T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39934800; 4124504 JF - 35th Annual Meeting of the Society for Neuroscience AU - Parr-Brownlie, L C AU - Bergstrom, D A AU - Itoga, C A AU - Hu, D. AU - Smith, C.P.S. AU - Walters, J R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Carbamate compounds KW - Lesions KW - Rats KW - Oscillations KW - Basal ganglia KW - Urethane KW - Cortex (motor) KW - Thalamus KW - Dopamine KW - Ganglia KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39934800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Enhanced+Slow+Oscillations+in+Neuronal+Activity+of+Basal+Ganglia+Output+Nuclei+after+Dopamine+Cell+Lesion+in+Urethane+Anesthetized+Rats%3A+Exploring+Effects+on+Ventrolateral+Thalamus+and+Motor+Cortex&rft.au=Parr-Brownlie%2C+L+C%3BBergstrom%2C+D+A%3BItoga%2C+C+A%3BHu%2C+D.%3BSmith%2C+C.P.S.%3BWalters%2C+J+R&rft.aulast=Parr-Brownlie&rft.aufirst=L&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of GSK - 3 or HDAC Increases the Activity of BDNF Promoter III T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39934001; 4131901 JF - 35th Annual Meeting of the Society for Neuroscience AU - Yasuda, S AU - Liang, M H AU - Chuang, D M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Promoters KW - Histone deacetylase KW - Brain-derived neurotrophic factor KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39934001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Inhibition+of+GSK+-+3+or+HDAC+Increases+the+Activity+of+BDNF+Promoter+III&rft.au=Yasuda%2C+S%3BLiang%2C+M+H%3BChuang%2C+D+M&rft.aulast=Yasuda&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuronal Activity Promotes Conversion of Pro - to Mature Brain - Derived Neurotrophic Factor (BDNF) in the Dendrites of Hippocampal Neurons T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39932163; 4125353 JF - 35th Annual Meeting of the Society for Neuroscience AU - Nagappan, G AU - Zaitsev, E AU - Chang, J H AU - Lu, B. Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Brain-derived neurotrophic factor KW - Neurotrophic factors KW - Hippocampus KW - Neurons KW - Dendrites KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39932163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neuronal+Activity+Promotes+Conversion+of+Pro+-+to+Mature+Brain+-+Derived+Neurotrophic+Factor+%28BDNF%29+in+the+Dendrites+of+Hippocampal+Neurons&rft.au=Nagappan%2C+G%3BZaitsev%2C+E%3BChang%2C+J+H%3BLu%2C+B.&rft.aulast=Nagappan&rft.aufirst=G&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Cardiotrophin - 1 As a VIP and Choline Acetyltransferase - Inducing Factor in Extracts of Rat Footpads T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39930332; 4125330 JF - 35th Annual Meeting of the Society for Neuroscience AU - Coulombe, J N AU - Habecker, B AU - Guidry, G AU - McKinnon, L AU - Jaffe, H AU - Sun, Y E AU - Landis, S Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Vasoactive intestinal peptide KW - Choline O-acetyltransferase KW - Choline KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39930332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Identification+of+Cardiotrophin+-+1+As+a+VIP+and+Choline+Acetyltransferase+-+Inducing+Factor+in+Extracts+of+Rat+Footpads&rft.au=Coulombe%2C+J+N%3BHabecker%2C+B%3BGuidry%2C+G%3BMcKinnon%2C+L%3BJaffe%2C+H%3BSun%2C+Y+E%3BLandis%2C+S&rft.aulast=Coulombe&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Behavioral Phenotypes of Galanin Receptor Subtype 2 Null Mutant Mice T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39930111; 4134839 JF - 35th Annual Meeting of the Society for Neuroscience AU - Bailey, K R AU - Hohmann, J G AU - Pavlova, M AU - Crawley, J N Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Mice KW - Mutants KW - Galanin receptors KW - Phenotypes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39930111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Behavioral+Phenotypes+of+Galanin+Receptor+Subtype+2+Null+Mutant+Mice&rft.au=Bailey%2C+K+R%3BHohmann%2C+J+G%3BPavlova%2C+M%3BCrawley%2C+J+N&rft.aulast=Bailey&rft.aufirst=K&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a Novel Transmembrane Protein Important for Oligodendrocyte Membrane Formation Using Gene Expression Profiling T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39928010; 4132212 JF - 35th Annual Meeting of the Society for Neuroscience AU - Nielsen, J A AU - Maric, D AU - Lau, P AU - Barker, J L AU - Hudson, L D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Membrane proteins KW - Gene expression KW - Oligodendrocytes KW - Profiling KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39928010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Identification+of+a+Novel+Transmembrane+Protein+Important+for+Oligodendrocyte+Membrane+Formation+Using+Gene+Expression+Profiling&rft.au=Nielsen%2C+J+A%3BMaric%2C+D%3BLau%2C+P%3BBarker%2C+J+L%3BHudson%2C+L+D&rft.aulast=Nielsen&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Task Channels Mediate Leak Currents That Modulate Respiratory Rhythm Generation In Vitro T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39926956; 4132755 JF - 35th Annual Meeting of the Society for Neuroscience AU - Smerin, S E AU - Koizumi, H AU - Zhang, R AU - Moorjani, B AU - Smith, J C Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Channels KW - Respiration KW - Rhythms KW - Metabolism KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39926956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Task+Channels+Mediate+Leak+Currents+That+Modulate+Respiratory+Rhythm+Generation+In+Vitro&rft.au=Smerin%2C+S+E%3BKoizumi%2C+H%3BZhang%2C+R%3BMoorjani%2C+B%3BSmith%2C+J+C&rft.aulast=Smerin&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Specific Endosomal Associations During the Trafficking of Synaptic Glutamate Receptors T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39926613; 4133922 JF - 35th Annual Meeting of the Society for Neuroscience AU - Petralia, R S AU - Dunbar, L A AU - Wang, Y AU - Wenthold, R J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Glutamic acid receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39926613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Specific+Endosomal+Associations+During+the+Trafficking+of+Synaptic+Glutamate+Receptors&rft.au=Petralia%2C+R+S%3BDunbar%2C+L+A%3BWang%2C+Y%3BWenthold%2C+R+J&rft.aulast=Petralia&rft.aufirst=R&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Peripheral Nerve Stimulation (PNS) Enhances Learning of a Functional Motor Task in Chronic Stroke Patients T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39925938; 4129490 JF - 35th Annual Meeting of the Society for Neuroscience AU - Celnik, P A AU - Hummel, F AU - Harris-Love, M AU - Cohen, L G Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Peripheral nerves KW - Learning KW - Stroke KW - Peripheral nervous system KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39925938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Peripheral+Nerve+Stimulation+%28PNS%29+Enhances+Learning+of+a+Functional+Motor+Task+in+Chronic+Stroke+Patients&rft.au=Celnik%2C+P+A%3BHummel%2C+F%3BHarris-Love%2C+M%3BCohen%2C+L+G&rft.aulast=Celnik&rft.aufirst=P&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of the Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Receptor in Bovine Chromaffin Cells that Mediates Calcium - dependent Secretion T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39924423; 4130665 JF - 35th Annual Meeting of the Society for Neuroscience AU - Mustafa, T AU - Eiden, L E Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Calcium KW - Secretion KW - Pituitary adenylate cyclase-activating polypeptide KW - Chromaffin cells KW - Pituitary adenylate cyclase-activating polypeptide receptors KW - Polypeptides KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39924423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Characterization+of+the+Pituitary+Adenylate+Cyclase+Activating+Polypeptide+%28PACAP%29+Receptor+in+Bovine+Chromaffin+Cells+that+Mediates+Calcium+-+dependent+Secretion&rft.au=Mustafa%2C+T%3BEiden%2C+L+E&rft.aulast=Mustafa&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Degenerative Changes in the Peripheral Retina of Transgenic Animals Containing the Mutated Mouse Myocilin Gene T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39924328; 4126453 JF - 35th Annual Meeting of the Society for Neuroscience AU - Senatorov, V V AU - Malyukova, I V AU - Fariss, R N AU - Wawrousek, E F AU - Swaminathan, S AU - Sharan, S K AU - Tomarev, S I Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Retina KW - Transgenic animals KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39924328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Degenerative+Changes+in+the+Peripheral+Retina+of+Transgenic+Animals+Containing+the+Mutated+Mouse+Myocilin+Gene&rft.au=Senatorov%2C+V+V%3BMalyukova%2C+I+V%3BFariss%2C+R+N%3BWawrousek%2C+E+F%3BSwaminathan%2C+S%3BSharan%2C+S+K%3BTomarev%2C+S+I&rft.aulast=Senatorov&rft.aufirst=V&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Catechol - O - Methyltransferase val158met Genotype on Attentional Control T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39923908; 4132951 JF - 35th Annual Meeting of the Society for Neuroscience AU - Blasi, G AU - Mattay, V S AU - Bertolino, A AU - Elvevag, B AU - Callicott, J H AU - Das, S AU - Kolachana, B S AU - Egan, M F AU - Goldberg, T E AU - Weinberger, D R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Attention KW - Genotypes KW - Methyltransferase KW - Catechol KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39923908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effect+of+Catechol+-+O+-+Methyltransferase+val158met+Genotype+on+Attentional+Control&rft.au=Blasi%2C+G%3BMattay%2C+V+S%3BBertolino%2C+A%3BElvevag%2C+B%3BCallicott%2C+J+H%3BDas%2C+S%3BKolachana%2C+B+S%3BEgan%2C+M+F%3BGoldberg%2C+T+E%3BWeinberger%2C+D+R&rft.aulast=Blasi&rft.aufirst=G&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mouse Disabled - 1 Regulates Neuronal Nuclear Positioning in a Drosophila Eye Model T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39923901; 4132154 JF - 35th Annual Meeting of the Society for Neuroscience AU - Pramatarova, A AU - Ochalski, P G AU - Matsuki, T AU - Lee, C H AU - Howell, B W Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Eye KW - Positioning systems KW - Drosophila KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39923901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Mouse+Disabled+-+1+Regulates+Neuronal+Nuclear+Positioning+in+a+Drosophila+Eye+Model&rft.au=Pramatarova%2C+A%3BOchalski%2C+P+G%3BMatsuki%2C+T%3BLee%2C+C+H%3BHowell%2C+B+W&rft.aulast=Pramatarova&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lithium Normalizes Dendritic Localization of val66met Polymorphism of Brain - derived Neurotrophic Factor ( BDNFmet ): Therapeutic Implications T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39923787; 4131893 JF - 35th Annual Meeting of the Society for Neuroscience AU - Du, J. AU - Suzuki, K AU - Guhan, N AU - Wei, Y AU - Wu, J. AU - Lu, B. AU - Manji, H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Lithium KW - Brain KW - Neurotrophic factors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39923787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Lithium+Normalizes+Dendritic+Localization+of+val66met+Polymorphism+of+Brain+-+derived+Neurotrophic+Factor+%28+BDNFmet+%29%3A+Therapeutic+Implications&rft.au=Du%2C+J.%3BSuzuki%2C+K%3BGuhan%2C+N%3BWei%2C+Y%3BWu%2C+J.%3BLu%2C+B.%3BManji%2C+H&rft.aulast=Du&rft.aufirst=J.&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - 5'UTR of BDNF Transcript Dictates mRNA Trafficking and Local Translation in Dendrites of Hippocampal Neurons T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39922370; 4125352 JF - 35th Annual Meeting of the Society for Neuroscience AU - Zaitsev, E N AU - Guhan, N AU - Yang, F AU - Lu, B. Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Translation KW - Transcription KW - 5' Untranslated regions KW - Brain-derived neurotrophic factor KW - Hippocampus KW - Neurons KW - Dendrites KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39922370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=5%27UTR+of+BDNF+Transcript+Dictates+mRNA+Trafficking+and+Local+Translation+in+Dendrites+of+Hippocampal+Neurons&rft.au=Zaitsev%2C+E+N%3BGuhan%2C+N%3BYang%2C+F%3BLu%2C+B.&rft.aulast=Zaitsev&rft.aufirst=E&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Striatal Volumes in Young Alcoholics and Children of Alcoholics T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39921822; 4121745 JF - 35th Annual Meeting of the Society for Neuroscience AU - Hommer, D W AU - Momenan, R AU - Bjork, J M AU - Kerich, M J AU - Israe, M E Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Children KW - Alcoholics KW - Neostriatum KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39921822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Striatal+Volumes+in+Young+Alcoholics+and+Children+of+Alcoholics&rft.au=Hommer%2C+D+W%3BMomenan%2C+R%3BBjork%2C+J+M%3BKerich%2C+M+J%3BIsrae%2C+M+E&rft.aulast=Hommer&rft.aufirst=D&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Measurement of Trophins, Peptides and Cytokines in Blood of Down Syndrome and Autistic Newborns and Controls T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39919058; 4128513 JF - 35th Annual Meeting of the Society for Neuroscience AU - Nelson, P G AU - Kuddo, T AU - Song, E AU - Dambrosia, J AU - Kohler, S AU - Satyanarayana, G AU - VanDunk, C AU - Grether, J AU - Nelson, K B Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Blood KW - Cytokines KW - Down's syndrome KW - Neonates KW - Peptides KW - Symptoms KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39919058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Measurement+of+Trophins%2C+Peptides+and+Cytokines+in+Blood+of+Down+Syndrome+and+Autistic+Newborns+and+Controls&rft.au=Nelson%2C+P+G%3BKuddo%2C+T%3BSong%2C+E%3BDambrosia%2C+J%3BKohler%2C+S%3BSatyanarayana%2C+G%3BVanDunk%2C+C%3BGrether%2C+J%3BNelson%2C+K+B&rft.aulast=Nelson&rft.aufirst=P&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Odorant - induced Activity Accelerates Glomerular Refinement in the Mammalian Olfactory Bulb T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39918816; 4129011 JF - 35th Annual Meeting of the Society for Neuroscience AU - Kerr, M A AU - Belluscio, L Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Odors KW - Odorants KW - Olfactory bulb KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39918816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Odorant+-+induced+Activity+Accelerates+Glomerular+Refinement+in+the+Mammalian+Olfactory+Bulb&rft.au=Kerr%2C+M+A%3BBelluscio%2C+L&rft.aulast=Kerr&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Endogenous and Exogenous Cannabinoids Potentiate Glycine Receptor - mediated Responses Through a CB Receptor Independent Mechanism in Xenopus Oocytes T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39918365; 4130648 JF - 35th Annual Meeting of the Society for Neuroscience AU - Sun, H AU - Hejazi, N AU - Oz, M. AU - Zhang, L Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Oocytes KW - Glycine receptors KW - Amphibiotic species KW - Xenopus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39918365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Endogenous+and+Exogenous+Cannabinoids+Potentiate+Glycine+Receptor+-+mediated+Responses+Through+a+CB+Receptor+Independent+Mechanism+in+Xenopus+Oocytes&rft.au=Sun%2C+H%3BHejazi%2C+N%3BOz%2C+M.%3BZhang%2C+L&rft.aulast=Sun&rft.aufirst=H&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Experimental Strategy that Allows the Identification of Functionally Critical Amino Acids in the M3 Muscarinic Acetylcholine Receptor 149 G-Protein-Linked Receptors: Muscarinic T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39918180; 4122106 JF - 35th Annual Meeting of the Society for Neuroscience AU - Li, B. AU - Scarselli, M AU - Knudsen, C D AU - McMillin, S M AU - Wess, J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Amino acids KW - Acetylcholine receptors (muscarinic) KW - Neurotransmitters KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39918180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=A+Novel+Experimental+Strategy+that+Allows+the+Identification+of+Functionally+Critical+Amino+Acids+in+the+M3+Muscarinic+Acetylcholine+Receptor+149+G-Protein-Linked+Receptors%3A+Muscarinic&rft.au=Li%2C+B.%3BScarselli%2C+M%3BKnudsen%2C+C+D%3BMcMillin%2C+S+M%3BWess%2C+J&rft.aulast=Li&rft.aufirst=B.&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Maturation of GABA@@dA@ Receptor - Mediated Synaptic Transmission in Adult - Born Dentate Gyrus Granule Cells T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39917578; 4121992 JF - 35th Annual Meeting of the Society for Neuroscience AU - Karten, Y.J.G. AU - Brewer, M D AU - Dayer, A G AU - Cameron, H A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Granule cells KW - ^g-Aminobutyric acid A receptors KW - Synaptic transmission KW - Dentate gyrus KW - Sexual maturity KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39917578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Maturation+of+GABA%40%40dA%40+Receptor+-+Mediated+Synaptic+Transmission+in+Adult+-+Born+Dentate+Gyrus+Granule+Cells&rft.au=Karten%2C+Y.J.G.%3BBrewer%2C+M+D%3BDayer%2C+A+G%3BCameron%2C+H+A&rft.aulast=Karten&rft.aufirst=Y.J.G.&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Are Task Channels a Target for Muscarinic Modulation in Hippocampal Interneurons? T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39917298; 4128928 JF - 35th Annual Meeting of the Society for Neuroscience AU - Torborg, C L AU - Lawrence, J AU - Jeffries, B AU - Berg, A P AU - Bayliss, D A AU - McBain, C J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Channels KW - Interneurons KW - Hippocampus KW - Acetylcholine receptors (muscarinic) KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39917298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Are+Task+Channels+a+Target+for+Muscarinic+Modulation+in+Hippocampal+Interneurons%3F&rft.au=Torborg%2C+C+L%3BLawrence%2C+J%3BJeffries%2C+B%3BBerg%2C+A+P%3BBayliss%2C+D+A%3BMcBain%2C+C+J&rft.aulast=Torborg&rft.aufirst=C&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reduced Prefrontal g - Aminobutyric Acid Levels in Patients with Current Major Depression Determined by Proton Magnetic Resonance Spectroscopy T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39913630; 4119166 JF - 35th Annual Meeting of the Society for Neuroscience AU - Hasler, G AU - van der Veen, J AU - Tumonis, T AU - Shen, J AU - Drevets, W Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Spectroscopy KW - Depression KW - Magnetic resonance spectroscopy KW - Resonance KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39913630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Reduced+Prefrontal+g+-+Aminobutyric+Acid+Levels+in+Patients+with+Current+Major+Depression+Determined+by+Proton+Magnetic+Resonance+Spectroscopy&rft.au=Hasler%2C+G%3Bvan+der+Veen%2C+J%3BTumonis%2C+T%3BShen%2C+J%3BDrevets%2C+W&rft.aulast=Hasler&rft.aufirst=G&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamics of Ca@@u2+@ Signals in Soma and Dendrities Due to Activation of Nicotinic Acetylcholine Receptors in Rat Hippocampal Interneurons T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39913496; 4133986 JF - 35th Annual Meeting of the Society for Neuroscience AU - Fayuk, D A AU - Yakel, J L Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Acetylcholine receptors (nicotinic) KW - Interneurons KW - Hippocampus KW - Calcium signalling KW - Neurotransmitters KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39913496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Dynamics+of+Ca%40%40u2%2B%40+Signals+in+Soma+and+Dendrities+Due+to+Activation+of+Nicotinic+Acetylcholine+Receptors+in+Rat+Hippocampal+Interneurons&rft.au=Fayuk%2C+D+A%3BYakel%2C+J+L&rft.aulast=Fayuk&rft.aufirst=D&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Local Protein Synthesis on Axonal Mitochondria in Superior Cervical Ganglion Neurons T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39912995; 4127094 JF - 35th Annual Meeting of the Society for Neuroscience AU - Hillefors, M S AU - Gioio, A E AU - Kaplan, B B Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Superior cervical ganglion KW - Protein biosynthesis KW - Mitochondria KW - Neurons KW - Protein synthesis KW - Ganglia KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39912995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effects+of+Local+Protein+Synthesis+on+Axonal+Mitochondria+in+Superior+Cervical+Ganglion+Neurons&rft.au=Hillefors%2C+M+S%3BGioio%2C+A+E%3BKaplan%2C+B+B&rft.aulast=Hillefors&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modulation of Neuronal Activity in the Pre - Botzinger Complex by Medullary Raphe Neurons T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39912747; 4127796 JF - 35th Annual Meeting of the Society for Neuroscience AU - Ptak, K AU - Milescu, L S AU - Richerson, G B AU - Smith, J C Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Neuromodulation KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39912747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Modulation+of+Neuronal+Activity+in+the+Pre+-+Botzinger+Complex+by+Medullary+Raphe+Neurons&rft.au=Ptak%2C+K%3BMilescu%2C+L+S%3BRicherson%2C+G+B%3BSmith%2C+J+C&rft.aulast=Ptak&rft.aufirst=K&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Role for PICK1 - Dependent GluR2 Trafficking in Depolarization - Induced Depression (DID) at Hippocampal Mossy Fiber - - CA3 Pyramid Synapses T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39911516; 4125572 JF - 35th Annual Meeting of the Society for Neuroscience AU - Ho, T W AU - Pelkey, K A AU - Takamiya, K AU - Xia, J AU - Huganir, R L AU - McBain, C J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Fibers KW - Depression KW - Synaptic depression KW - ^a-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors KW - Hippocampus KW - Mossy fibers KW - Synapses KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39911516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=A+Role+for+PICK1+-+Dependent+GluR2+Trafficking+in+Depolarization+-+Induced+Depression+%28DID%29+at+Hippocampal+Mossy+Fiber+-+-+CA3+Pyramid+Synapses&rft.au=Ho%2C+T+W%3BPelkey%2C+K+A%3BTakamiya%2C+K%3BXia%2C+J%3BHuganir%2C+R+L%3BMcBain%2C+C+J&rft.aulast=Ho&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuregulin - 1 Depotentiates LTP at Hippocampal CA1 Synapses T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39911235; 4127329 JF - 35th Annual Meeting of the Society for Neuroscience AU - Buonanno, A AU - Kwon, O AU - Longart, M AU - Hoffman, D AU - Vullhorst, D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Long-term potentiation KW - Neuregulin KW - Synapses KW - Hippocampus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39911235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neuregulin+-+1+Depotentiates+LTP+at+Hippocampal+CA1+Synapses&rft.au=Buonanno%2C+A%3BKwon%2C+O%3BLongart%2C+M%3BHoffman%2C+D%3BVullhorst%2C+D&rft.aulast=Buonanno&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of a Truncated Isoform of Human Metabotropic Glutamate Receptor 3 T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39910629; 4120241 JF - 35th Annual Meeting of the Society for Neuroscience AU - Sartorius, L J AU - Lipska, B K AU - Sei, Y AU - Ren-Patterson, R AU - Kleinman, J E AU - Harrison, P J AU - Weinberger, D R AU - Lu, B. Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Glutamic acid receptors (metabotropic) KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39910629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Characterization+of+a+Truncated+Isoform+of+Human+Metabotropic+Glutamate+Receptor+3&rft.au=Sartorius%2C+L+J%3BLipska%2C+B+K%3BSei%2C+Y%3BRen-Patterson%2C+R%3BKleinman%2C+J+E%3BHarrison%2C+P+J%3BWeinberger%2C+D+R%3BLu%2C+B.&rft.aulast=Sartorius&rft.aufirst=L&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Motor Cortical Oscillatory Activation Patterns in Ipsilateral Versus Contralateral Self - Paced Movements: An ECoG Study T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39909418; 4124561 JF - 35th Annual Meeting of the Society for Neuroscience AU - Mari, Z AU - Matsuhashi, M AU - Wheaton, L AU - Sato, S AU - Hallett, M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Self KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39909418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Human+Motor+Cortical+Oscillatory+Activation+Patterns+in+Ipsilateral+Versus+Contralateral+Self+-+Paced+Movements%3A+An+ECoG+Study&rft.au=Mari%2C+Z%3BMatsuhashi%2C+M%3BWheaton%2C+L%3BSato%2C+S%3BHallett%2C+M&rft.aulast=Mari&rft.aufirst=Z&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuronal Excess of Ferroxidase - active Ferritin Causes Late - onset Neurodegeneration in Drosophila T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39908579; 4129957 JF - 35th Annual Meeting of the Society for Neuroscience AU - Missirlis, F AU - Kosmidis, S AU - Botella, J A AU - Schnewuly, S AU - Skoulakis, E.M.C. AU - Rouault, T A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Neurodegeneration KW - Ferritin KW - Ferroxidase KW - Drosophila KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39908579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neuronal+Excess+of+Ferroxidase+-+active+Ferritin+Causes+Late+-+onset+Neurodegeneration+in+Drosophila&rft.au=Missirlis%2C+F%3BKosmidis%2C+S%3BBotella%2C+J+A%3BSchnewuly%2C+S%3BSkoulakis%2C+E.M.C.%3BRouault%2C+T+A&rft.aulast=Missirlis&rft.aufirst=F&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - GnRH - 1 Regulates GnRH - 1 Neurons T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39907769; 4127755 JF - 35th Annual Meeting of the Society for Neuroscience AU - Duittoz, A AU - Constantin, S AU - Skinner, D AU - Wray, S Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Gonadotropin-releasing hormone KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39907769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=GnRH+-+1+Regulates+GnRH+-+1+Neurons&rft.au=Duittoz%2C+A%3BConstantin%2C+S%3BSkinner%2C+D%3BWray%2C+S&rft.aulast=Duittoz&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of Corticotrophin - Releasing Hormone Transcription by Inducible cAMP Early Repressor(ICER) T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39906280; 4119158 JF - 35th Annual Meeting of the Society for Neuroscience AU - Liu, Y AU - Aguilera, G Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Hormones KW - Transcription KW - Cyclic AMP KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39906280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Inhibition+of+Corticotrophin+-+Releasing+Hormone+Transcription+by+Inducible+cAMP+Early+Repressor%28ICER%29&rft.au=Liu%2C+Y%3BAguilera%2C+G&rft.aulast=Liu&rft.aufirst=Y&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effects of Cholecystokinin on Ventral Neurons in the Spinal Cord of the Neonatal Rat and Mouse T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39906265; 4129288 JF - 35th Annual Meeting of the Society for Neuroscience AU - Yang, K AU - Morales, M AU - Renaud, L P AU - O'Donovan, M J AU - Lupica, C R AU - Oz, M. Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Spinal cord KW - Cholecystokinin KW - Neonates KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39906265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Effects+of+Cholecystokinin+on+Ventral+Neurons+in+the+Spinal+Cord+of+the+Neonatal+Rat+and+Mouse&rft.au=Yang%2C+K%3BMorales%2C+M%3BRenaud%2C+L+P%3BO%27Donovan%2C+M+J%3BLupica%2C+C+R%3BOz%2C+M.&rft.aulast=Yang&rft.aufirst=K&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - EEG Coherence Analysis of Visuomotor Networks: Distinguishable Paths in the Brain for Varying Processing Demands T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39905777; 4124273 JF - 35th Annual Meeting of the Society for Neuroscience AU - Wheaton, L A AU - Hattori, N AU - Hallett, M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Brain KW - Oculomotor behavior KW - EEG KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39905777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=EEG+Coherence+Analysis+of+Visuomotor+Networks%3A+Distinguishable+Paths+in+the+Brain+for+Varying+Processing+Demands&rft.au=Wheaton%2C+L+A%3BHattori%2C+N%3BHallett%2C+M&rft.aulast=Wheaton&rft.aufirst=L&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rhesus Monkeys with Orbital Prefrontal Cortex Lesions can Learn to Inhibit Prepotent Responses in the Reversed - Reward Contingency Task T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39903525; 4134857 JF - 35th Annual Meeting of the Society for Neuroscience AU - Chudasama, Y AU - Kralik, J D AU - Murray, E A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Lesions KW - Reinforcement KW - Contingency KW - Cortex (prefrontal) KW - Macaca mulatta KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39903525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Rhesus+Monkeys+with+Orbital+Prefrontal+Cortex+Lesions+can+Learn+to+Inhibit+Prepotent+Responses+in+the+Reversed+-+Reward+Contingency+Task&rft.au=Chudasama%2C+Y%3BKralik%2C+J+D%3BMurray%2C+E+A&rft.aulast=Chudasama&rft.aufirst=Y&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PKC and GRK Regulation of D@@d1@ Dopamine Receptor Signaling T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39903158; 4120259 JF - 35th Annual Meeting of the Society for Neuroscience AU - Rankin, M L AU - Sibley, D R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Signal transduction KW - Dopamine D1 receptors KW - Protein kinase C KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39903158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=PKC+and+GRK+Regulation+of+D%40%40d1%40+Dopamine+Receptor+Signaling&rft.au=Rankin%2C+M+L%3BSibley%2C+D+R&rft.aulast=Rankin&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - D@@d1@ Dopamine Receptor Expression is Regulated by Direct Interaction with the Chaperone Protein Calnexin T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39903095; 4120258 JF - 35th Annual Meeting of the Society for Neuroscience AU - Free, R B AU - Hazelwood, L A AU - Cabrera, D M AU - Spalding, H N AU - Sibley, D R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Chaperones KW - Dopamine D1 receptors KW - Calnexin KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39903095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=D%40%40d1%40+Dopamine+Receptor+Expression+is+Regulated+by+Direct+Interaction+with+the+Chaperone+Protein+Calnexin&rft.au=Free%2C+R+B%3BHazelwood%2C+L+A%3BCabrera%2C+D+M%3BSpalding%2C+H+N%3BSibley%2C+D+R&rft.aulast=Free&rft.aufirst=R&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Two Neural Circuits for Learning DNMS with Short Delays T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39902440; 4120885 JF - 35th Annual Meeting of the Society for Neuroscience AU - Malloy, M M AU - Turchi, J AU - Lowther, R AU - Yu, D. AU - Saunders, R C AU - Mishkin, M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Learning KW - Neural networks KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39902440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Two+Neural+Circuits+for+Learning+DNMS+with+Short+Delays&rft.au=Malloy%2C+M+M%3BTurchi%2C+J%3BLowther%2C+R%3BYu%2C+D.%3BSaunders%2C+R+C%3BMishkin%2C+M&rft.aulast=Malloy&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dissociation of Emotion-Laden and Cognitive Prefrontal Cortical Activity T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39901759; 4122904 JF - 35th Annual Meeting of the Society for Neuroscience AU - Goldman, A L AU - Pezawas, L AU - Chen, G AU - Meyer-Lindenberg, A AU - Goldberg, T E AU - Saad, Z S AU - Mattay, V S AU - Weinberger, D R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Cognitive ability KW - Dissociation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39901759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Dissociation+of+Emotion-Laden+and+Cognitive+Prefrontal+Cortical+Activity&rft.au=Goldman%2C+A+L%3BPezawas%2C+L%3BChen%2C+G%3BMeyer-Lindenberg%2C+A%3BGoldberg%2C+T+E%3BSaad%2C+Z+S%3BMattay%2C+V+S%3BWeinberger%2C+D+R&rft.aulast=Goldman&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Suppressive Effect of Peripheral Stimulation on Corticospinal Excitability Decreases for Muscle Involved in a Motor - Learning Task T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39901378; 4122563 JF - 35th Annual Meeting of the Society for Neuroscience AU - Russmann, H AU - Meunier, S O AU - Hallett, M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Muscles KW - Motor skill learning KW - Pyramidal tracts KW - Excitability KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39901378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Suppressive+Effect+of+Peripheral+Stimulation+on+Corticospinal+Excitability+Decreases+for+Muscle+Involved+in+a+Motor+-+Learning+Task&rft.au=Russmann%2C+H%3BMeunier%2C+S+O%3BHallett%2C+M&rft.aulast=Russmann&rft.aufirst=H&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Brain Metabolic Fluctuations During Sleep T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39900839; 4122826 JF - 35th Annual Meeting of the Society for Neuroscience AU - Fukunaga, M AU - Horovitz, S G AU - van Gelderen, P AU - de Zwart, J.A. AU - Duyn, J H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Brain KW - Sleep KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39900839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Brain+Metabolic+Fluctuations+During+Sleep&rft.au=Fukunaga%2C+M%3BHorovitz%2C+S+G%3Bvan+Gelderen%2C+P%3Bde+Zwart%2C+J.A.%3BDuyn%2C+J+H&rft.aulast=Fukunaga&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oxidative Modifications of CaMKII Inhibit its Autophosphorylation T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39900460; 4123301 JF - 35th Annual Meeting of the Society for Neuroscience AU - Shetty, P K AU - Huang, F AU - Huang, K Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Ca@@u2+@/calmodulin-dependent protein kinase II KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39900460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Oxidative+Modifications+of+CaMKII+Inhibit+its+Autophosphorylation&rft.au=Shetty%2C+P+K%3BHuang%2C+F%3BHuang%2C+K&rft.aulast=Shetty&rft.aufirst=P&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Identification of Distinct Populations of Neurons Involved in Drosophila Wing Expansion T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39899903; 4120670 JF - 35th Annual Meeting of the Society for Neuroscience AU - Lemon, W C AU - Luan, H AU - Nitabach, M N AU - Holmes, T C AU - White, B H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Wings KW - Neurons KW - Drosophila KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39899903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Functional+Identification+of+Distinct+Populations+of+Neurons+Involved+in+Drosophila+Wing+Expansion&rft.au=Lemon%2C+W+C%3BLuan%2C+H%3BNitabach%2C+M+N%3BHolmes%2C+T+C%3BWhite%2C+B+H&rft.aulast=Lemon&rft.aufirst=W&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Scopolamine Differentially Modulates Attention and Emotion T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39899850; 4128009 JF - 35th Annual Meeting of the Society for Neuroscience AU - Furey, M L AU - Drevets, W C Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Scopolamine KW - Emotions KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39899850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Scopolamine+Differentially+Modulates+Attention+and+Emotion&rft.au=Furey%2C+M+L%3BDrevets%2C+W+C&rft.aulast=Furey&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microglial NADPH Oxidase is the Target of Femtomolar Neuroprotection Against Oxidative Stress for GIF, Tripeptide of PACAP - 38 T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39899791; 4133904 JF - 35th Annual Meeting of the Society for Neuroscience AU - Yang, S Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Stress KW - Oxidative stress KW - NADPH oxidase KW - Pituitary adenylate cyclase-activating polypeptide KW - Neuroprotection KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39899791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Microglial+NADPH+Oxidase+is+the+Target+of+Femtomolar+Neuroprotection+Against+Oxidative+Stress+for+GIF%2C+Tripeptide+of+PACAP+-+38&rft.au=Yang%2C+S&rft.aulast=Yang&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Neuroimaging of Ambiguous Haplotypes Reveals Impact of Genetic Variation in COMT on Prefrontal Function T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39899419; 4126070 JF - 35th Annual Meeting of the Society for Neuroscience AU - Meyer-Lindenberg, A S AU - Nichols, T AU - Callicott, J AU - Ding, J AU - Kolachana, B AU - Buckholtz, J AU - Straub, R AU - Mattay, V S AU - Egan, M AU - Weinberger, D R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Neuroimaging KW - Haplotypes KW - Genetic diversity KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39899419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Functional+Neuroimaging+of+Ambiguous+Haplotypes+Reveals+Impact+of+Genetic+Variation+in+COMT+on+Prefrontal+Function&rft.au=Meyer-Lindenberg%2C+A+S%3BNichols%2C+T%3BCallicott%2C+J%3BDing%2C+J%3BKolachana%2C+B%3BBuckholtz%2C+J%3BStraub%2C+R%3BMattay%2C+V+S%3BEgan%2C+M%3BWeinberger%2C+D+R&rft.aulast=Meyer-Lindenberg&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - COMT val@@u158@met Polymorphism Impacts on Reactivity of Amygdala to Emotion - Laden Stimuli T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39899068; 4123022 JF - 35th Annual Meeting of the Society for Neuroscience AU - Mattay, V S AU - Blasi, G AU - Alce, G AU - Das, S AU - Callicott, J H AU - Kolachana, B S AU - Egan, M F AU - Sambataro, F AU - Meyer-Lindenberg, A AU - Hariri, A R AU - Weinberger, D R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Amygdala KW - Emotions KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39899068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=COMT+val%40%40u158%40met+Polymorphism+Impacts+on+Reactivity+of+Amygdala+to+Emotion+-+Laden+Stimuli&rft.au=Mattay%2C+V+S%3BBlasi%2C+G%3BAlce%2C+G%3BDas%2C+S%3BCallicott%2C+J+H%3BKolachana%2C+B+S%3BEgan%2C+M+F%3BSambataro%2C+F%3BMeyer-Lindenberg%2C+A%3BHariri%2C+A+R%3BWeinberger%2C+D+R&rft.aulast=Mattay&rft.aufirst=V&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ethanol Inhibits BDNF - Stimulated ERK Activation in Cerebellar Granule Cells T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39898550; 4123670 JF - 35th Annual Meeting of the Society for Neuroscience AU - Davis, M I AU - Ohrtman, J D AU - Stancik, E K AU - Lovinger, D M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Ethanol KW - Granule cells KW - Cerebellum KW - Brain-derived neurotrophic factor KW - Extracellular signal-regulated kinase KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39898550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Ethanol+Inhibits+BDNF+-+Stimulated+ERK+Activation+in+Cerebellar+Granule+Cells&rft.au=Davis%2C+M+I%3BOhrtman%2C+J+D%3BStancik%2C+E+K%3BLovinger%2C+D+M&rft.aulast=Davis&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rapid Antibody Staining of GnRH - 1 Neurons for Subsequent Laser - Capture Microdissection and RT - PCR Analysis T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39898340; 4127754 JF - 35th Annual Meeting of the Society for Neuroscience AU - Reuss, A E AU - Wray, S Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Lasers KW - Antibodies KW - Polymerase chain reaction KW - Neurons KW - Gonadotropin-releasing hormone KW - Nucleotide sequence KW - Staining KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39898340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Rapid+Antibody+Staining+of+GnRH+-+1+Neurons+for+Subsequent+Laser+-+Capture+Microdissection+and+RT+-+PCR+Analysis&rft.au=Reuss%2C+A+E%3BWray%2C+S&rft.aulast=Reuss&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Action Potential - Dependent Signaling between Axons and Glia T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39897675; 4125649 JF - 35th Annual Meeting of the Society for Neuroscience AU - Lee, P R AU - Fields, R D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Signal transduction KW - Action potential KW - Glia KW - Axons KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39897675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Action+Potential+-+Dependent+Signaling+between+Axons+and+Glia&rft.au=Lee%2C+P+R%3BFields%2C+R+D&rft.aulast=Lee&rft.aufirst=P&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Kinetics of Penetration Influence the Apparent Potency of Vanilloids on TRPV1 T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39896380; 4125787 JF - 35th Annual Meeting of the Society for Neuroscience AU - Lazar, J AU - Braun, D C AU - Toth, A AU - Wang, Y AU - Pearce, L V AU - Pavlyukovets, V A AU - Choi, H AU - Lee, J AU - Blumberg, P M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Kinetics KW - Capsaicin receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39896380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Kinetics+of+Penetration+Influence+the+Apparent+Potency+of+Vanilloids+on+TRPV1&rft.au=Lazar%2C+J%3BBraun%2C+D+C%3BToth%2C+A%3BWang%2C+Y%3BPearce%2C+L+V%3BPavlyukovets%2C+V+A%3BChoi%2C+H%3BLee%2C+J%3BBlumberg%2C+P+M&rft.aulast=Lazar&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selectivity for Cyclopean Contours in Macaque V2 Reflects Properties of a Simple Mechanism, Rather than High - Level Edge Representation T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39896310; 4119578 JF - 35th Annual Meeting of the Society for Neuroscience AU - Bredfeldt, C E AU - Cumming, B G Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Macaca KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39896310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Selectivity+for+Cyclopean+Contours+in+Macaque+V2+Reflects+Properties+of+a+Simple+Mechanism%2C+Rather+than+High+-+Level+Edge+Representation&rft.au=Bredfeldt%2C+C+E%3BCumming%2C+B+G&rft.aulast=Bredfeldt&rft.aufirst=C&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - COMT Val158Met Genotype and IQ Interact to Predict BOLD Response to Working Memory Challenge in Prefrontal Cortex T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39894790; 4126068 JF - 35th Annual Meeting of the Society for Neuroscience AU - Buckholtz, J W AU - Meyer-Lindenberg, A AU - Tan, H Y AU - Sust, S AU - Egan, M F AU - Goldberg, T E AU - Mattay, V S AU - Kolachana, B AU - Weinberger, D R AU - Callicott, J H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Short term memory KW - Cortex (prefrontal) KW - Genotypes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39894790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=COMT+Val158Met+Genotype+and+IQ+Interact+to+Predict+BOLD+Response+to+Working+Memory+Challenge+in+Prefrontal+Cortex&rft.au=Buckholtz%2C+J+W%3BMeyer-Lindenberg%2C+A%3BTan%2C+H+Y%3BSust%2C+S%3BEgan%2C+M+F%3BGoldberg%2C+T+E%3BMattay%2C+V+S%3BKolachana%2C+B%3BWeinberger%2C+D+R%3BCallicott%2C+J+H&rft.aulast=Buckholtz&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Chemical - Library Approach to Mining the Receptorome T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39893866; 4125398 JF - 35th Annual Meeting of the Society for Neuroscience AU - Roth, B L AU - Birkes, J A AU - Evans, J AU - Kroeze, W K AU - Fan, Y AU - Beeler, A A AU - Panek, J S AU - Schaus, S E AU - Snyder, J K AU - Porco, J A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Mining KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39893866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=A+Chemical+-+Library+Approach+to+Mining+the+Receptorome&rft.au=Roth%2C+B+L%3BBirkes%2C+J+A%3BEvans%2C+J%3BKroeze%2C+W+K%3BFan%2C+Y%3BBeeler%2C+A+A%3BPanek%2C+J+S%3BSchaus%2C+S+E%3BSnyder%2C+J+K%3BPorco%2C+J+A&rft.aulast=Roth&rft.aufirst=B&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distinct Electrophysiological Properties of Hippocampal CA2 Neurons 162 LTP Postsynaptic Mechanisms: Cellular Physiology T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39893501; 4122326 JF - 35th Annual Meeting of the Society for Neuroscience AU - Zhao, M AU - Dudek, S M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Physiology KW - Long-term potentiation KW - Hippocampus KW - Neurons KW - Electrophysiology KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39893501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Distinct+Electrophysiological+Properties+of+Hippocampal+CA2+Neurons+162+LTP+Postsynaptic+Mechanisms%3A+Cellular+Physiology&rft.au=Zhao%2C+M%3BDudek%2C+S+M&rft.aulast=Zhao&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Situ Hybridization Analysis of Changes in Heteronuclear Oxytocin and Vasopressin RNA During Lactation and the Estrous Cycle in the Rat Hypothalamus T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39893324; 4134728 JF - 35th Annual Meeting of the Society for Neuroscience AU - Scordalakes, E M AU - Yue, C AU - Mutsuga, N AU - Gainer, H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Lactation KW - RNA KW - Oxytocin KW - Vasopressin KW - Hybridization analysis KW - Hypothalamus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39893324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=In+Situ+Hybridization+Analysis+of+Changes+in+Heteronuclear+Oxytocin+and+Vasopressin+RNA+During+Lactation+and+the+Estrous+Cycle+in+the+Rat+Hypothalamus&rft.au=Scordalakes%2C+E+M%3BYue%2C+C%3BMutsuga%2C+N%3BGainer%2C+H&rft.aulast=Scordalakes&rft.aufirst=E&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Analysis in Adult Rat Hypothalamus Using an In Vivo Electroporation Technique T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39893212; 4134707 JF - 35th Annual Meeting of the Society for Neuroscience AU - Mutsuga-Nakayama, N AU - Wei, F AU - Fields, R L AU - Gainer, H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Electroporation KW - Gene expression KW - Hypothalamus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39893212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Gene+Expression+Analysis+in+Adult+Rat+Hypothalamus+Using+an+In+Vivo+Electroporation+Technique&rft.au=Mutsuga-Nakayama%2C+N%3BWei%2C+F%3BFields%2C+R+L%3BGainer%2C+H&rft.aulast=Mutsuga-Nakayama&rft.aufirst=N&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In the Act of Feeding: A Model of Reward, Decision, and Inhibitory Control T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39892836; 4134856 JF - 35th Annual Meeting of the Society for Neuroscience AU - Kralik, J D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Reinforcement KW - Feeding KW - Models KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39892836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=In+the+Act+of+Feeding%3A+A+Model+of+Reward%2C+Decision%2C+and+Inhibitory+Control&rft.au=Kralik%2C+J+D&rft.aulast=Kralik&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Repopulation of Dentate Granule Neurons Following Trimethyltin - Induced Injury in the Adolescent Mouse T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39891989; 4128299 JF - 35th Annual Meeting of the Society for Neuroscience AU - Aoyama, M AU - Wine, R N AU - McPherson, C A AU - Harry, G J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Adolescents KW - Injuries KW - Granule cells KW - Trimethyltin KW - Repopulation KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39891989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Repopulation+of+Dentate+Granule+Neurons+Following+Trimethyltin+-+Induced+Injury+in+the+Adolescent+Mouse&rft.au=Aoyama%2C+M%3BWine%2C+R+N%3BMcPherson%2C+C+A%3BHarry%2C+G+J&rft.aulast=Aoyama&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PKB Phosphorylation of the NMDA Receptor NR2C Subunit and Binding to 14 - 3 - 3e T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39891084; 4132395 JF - 35th Annual Meeting of the Society for Neuroscience AU - Chen, B AU - Roche, K W Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Glutamic acid receptors KW - N-Methyl-D-aspartic acid receptors KW - Phosphorylation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39891084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=PKB+Phosphorylation+of+the+NMDA+Receptor+NR2C+Subunit+and+Binding+to+14+-+3+-+3e&rft.au=Chen%2C+B%3BRoche%2C+K+W&rft.aulast=Chen&rft.aufirst=B&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modeling the Behavior of Monkeys in Reward Schedules with Context - Dependent and Adaptive Reinforcement Learning T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39889622; 4134853 JF - 35th Annual Meeting of the Society for Neuroscience AU - La Camera, G. AU - Zeng, L AU - Pritchett, D L AU - Richmond, B J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Reinforcement KW - Learning KW - Learning behaviour KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39889622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Modeling+the+Behavior+of+Monkeys+in+Reward+Schedules+with+Context+-+Dependent+and+Adaptive+Reinforcement+Learning&rft.au=La+Camera%2C+G.%3BZeng%2C+L%3BPritchett%2C+D+L%3BRichmond%2C+B+J&rft.aulast=La+Camera&rft.aufirst=G.&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cue and Reward Signals Carried by Monkey Entorhinal Neurons during Reward Schedules T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39889573; 4134852 JF - 35th Annual Meeting of the Society for Neuroscience AU - Sugase-Miyamoto, Y AU - Richmond, B J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Reinforcement KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39889573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Cue+and+Reward+Signals+Carried+by+Monkey+Entorhinal+Neurons+during+Reward+Schedules&rft.au=Sugase-Miyamoto%2C+Y%3BRichmond%2C+B+J&rft.aulast=Sugase-Miyamoto&rft.aufirst=Y&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Co - Existence of g - Oscillations and Neuronal Avalanches in Cortical Networks T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39889543; 4134283 JF - 35th Annual Meeting of the Society for Neuroscience AU - Gireesh, E.Dharmaraj AU - Plenz, D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Avalanches KW - Oscillations KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39889543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Co+-+Existence+of+g+-+Oscillations+and+Neuronal+Avalanches+in+Cortical+Networks&rft.au=Gireesh%2C+E.Dharmaraj%3BPlenz%2C+D&rft.aulast=Gireesh&rft.aufirst=E.Dharmaraj&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rolipram Rescues Spatial Memory Deficits in Galanin - Overexpressing Transgenic Mice T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39889529; 4134838 JF - 35th Annual Meeting of the Society for Neuroscience AU - Rustay, N R AU - Crawley, J N Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Mice KW - Galanin KW - Spatial memory KW - Rolipram KW - Transgenic mice KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39889529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Rolipram+Rescues+Spatial+Memory+Deficits+in+Galanin+-+Overexpressing+Transgenic+Mice&rft.au=Rustay%2C+N+R%3BCrawley%2C+J+N&rft.aulast=Rustay&rft.aufirst=N&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Does Superior Colliculus Stimulation Directly Shift Attention or Produce a Visual Cue? T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39889504; 4122379 JF - 35th Annual Meeting of the Society for Neuroscience AU - Cavanaugh, J AU - Alvarez, B D AU - Wurtz, R H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Attention KW - Superior colliculus KW - Visual stimuli KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39889504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Does+Superior+Colliculus+Stimulation+Directly+Shift+Attention+or+Produce+a+Visual+Cue%3F&rft.au=Cavanaugh%2C+J%3BAlvarez%2C+B+D%3BWurtz%2C+R+H&rft.aulast=Cavanaugh&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High - and Low - Frequency Stimuli Preferentially Activate Different Steps in the ERK Cascade T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39889118; 4134206 JF - 35th Annual Meeting of the Society for Neuroscience AU - Hongpaisan, J AU - Winters, C A AU - Andrews, S B Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Extracellular signal-regulated kinase KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39889118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=High+-+and+Low+-+Frequency+Stimuli+Preferentially+Activate+Different+Steps+in+the+ERK+Cascade&rft.au=Hongpaisan%2C+J%3BWinters%2C+C+A%3BAndrews%2C+S+B&rft.aulast=Hongpaisan&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification and Characterization of pA134, a Novel Squid Axonal mrna and its Cognate Protein in the Mammalian Brain T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39888892; 4134175 JF - 35th Annual Meeting of the Society for Neuroscience AU - Mameza, M G AU - Lockard, J AU - Gioio, A E AU - Hillefors, M AU - Lavino, Z.Scotto AU - Kaplan, B B Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Brain KW - MRNA KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39888892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Identification+and+Characterization+of+pA134%2C+a+Novel+Squid+Axonal+mrna+and+its+Cognate+Protein+in+the+Mammalian+Brain&rft.au=Mameza%2C+M+G%3BLockard%2C+J%3BGioio%2C+A+E%3BHillefors%2C+M%3BLavino%2C+Z.Scotto%3BKaplan%2C+B+B&rft.aulast=Mameza&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lateralized Conceptual Processing in the Perirhinal Cortex During Object Naming Revealed using High - Resolution Fmri. T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39888286; 4119250 JF - 35th Annual Meeting of the Society for Neuroscience AU - Bellgowan, P.S.F. AU - Raymundo, N AU - Bodurka, J AU - Martin, A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Functional magnetic resonance imaging KW - Cortex KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39888286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Lateralized+Conceptual+Processing+in+the+Perirhinal+Cortex+During+Object+Naming+Revealed+using+High+-+Resolution+Fmri.&rft.au=Bellgowan%2C+P.S.F.%3BRaymundo%2C+N%3BBodurka%2C+J%3BMartin%2C+A&rft.aulast=Bellgowan&rft.aufirst=P.S.F.&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Disruption of mGluR8a - Mediated Calcium Channel Inhibition by Fluorophore - Asssisted Light Inactivation in Rat Sympathetic Neurons T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39888042; 4123821 JF - 35th Annual Meeting of the Society for Neuroscience AU - Guo, J AU - Chen, H AU - Puhl, H L AU - Ikeda, S R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Sympathetic nerves KW - Fluorophores KW - Calcium channels KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39888042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Disruption+of+mGluR8a+-+Mediated+Calcium+Channel+Inhibition+by+Fluorophore+-+Asssisted+Light+Inactivation+in+Rat+Sympathetic+Neurons&rft.au=Guo%2C+J%3BChen%2C+H%3BPuhl%2C+H+L%3BIkeda%2C+S+R&rft.aulast=Guo&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interaction of the Hereditary Spastic Paraplegia ( SPG20 ) Protein Spartin with Eps15 T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39887736; 4135083 JF - 35th Annual Meeting of the Society for Neuroscience AU - Bakowska, J C AU - Russell, J W AU - Pendleton, J AU - Blackstone, C Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Spastic paraplegia KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39887736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Interaction+of+the+Hereditary+Spastic+Paraplegia+%28+SPG20+%29+Protein+Spartin+with+Eps15&rft.au=Bakowska%2C+J+C%3BRussell%2C+J+W%3BPendleton%2C+J%3BBlackstone%2C+C&rft.aulast=Bakowska&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Centrally Acting Angiotensin II AT@@d1@ Receptor Antagonist Prevents the Isolation Stress - Induced Decrease in Cortical CRH@@d1@ Receptor and Benzodiazepine Binding T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39887473; 4122787 JF - 35th Annual Meeting of the Society for Neuroscience AU - Pavel, J AU - Armando, I AU - Bregonzio, C AU - Juorio, A AU - Macova, M AU - Saavedra, J M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Stress KW - Benzodiazepine KW - Angiotensin II KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39887473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=A+Centrally+Acting+Angiotensin+II+AT%40%40d1%40+Receptor+Antagonist+Prevents+the+Isolation+Stress+-+Induced+Decrease+in+Cortical+CRH%40%40d1%40+Receptor+and+Benzodiazepine+Binding&rft.au=Pavel%2C+J%3BArmando%2C+I%3BBregonzio%2C+C%3BJuorio%2C+A%3BMacova%2C+M%3BSaavedra%2C+J+M&rft.aulast=Pavel&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - BDNF Gene Expression is Differentially Regulated by Postsynaptic Activity Correlated and Uncorrelated with Synaptic Input to CA1 Hippocampal Neurons T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39886367; 4127336 JF - 35th Annual Meeting of the Society for Neuroscience AU - Fields, R D AU - Cohen, J E AU - Lee, P R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Brain-derived neurotrophic factor KW - Hippocampus KW - Neurons KW - Gene expression KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39886367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=BDNF+Gene+Expression+is+Differentially+Regulated+by+Postsynaptic+Activity+Correlated+and+Uncorrelated+with+Synaptic+Input+to+CA1+Hippocampal+Neurons&rft.au=Fields%2C+R+D%3BCohen%2C+J+E%3BLee%2C+P+R&rft.aulast=Fields&rft.aufirst=R&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Different Spatiotemporal Profiles in the Gamma Band for Processing Fearful, Angry, and Neutral Expressions: An MEG Study T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39886238; 4120036 DE: JF - 35th Annual Meeting of the Society for Neuroscience AU - Luo, Q AU - Holroyd, T AU - Jones, M AU - Hendler, T AU - Blair, J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39886238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Different+Spatiotemporal+Profiles+in+the+Gamma+Band+for+Processing+Fearful%2C+Angry%2C+and+Neutral+Expressions%3A+An+MEG+Study&rft.au=Luo%2C+Q%3BHolroyd%2C+T%3BJones%2C+M%3BHendler%2C+T%3BBlair%2C+J&rft.aulast=Luo&rft.aufirst=Q&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Pheromone Androstenol ( 5a - androst - 16 - en - 3a - ol ) is a Neurosteroid T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39884327; 4123793 JF - 35th Annual Meeting of the Society for Neuroscience AU - Kaminski, R M AU - Marini, H AU - Ortinski, P I AU - Yonekawa, W AU - Vicini, S AU - Rogawski, M A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Pheromones KW - Neurosteroids KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39884327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Pheromone+Androstenol+%28+5a+-+androst+-+16+-+en+-+3a+-+ol+%29+is+a+Neurosteroid&rft.au=Kaminski%2C+R+M%3BMarini%2C+H%3BOrtinski%2C+P+I%3BYonekawa%2C+W%3BVicini%2C+S%3BRogawski%2C+M+A&rft.aulast=Kaminski&rft.aufirst=R&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Medial Temporal Removals Preserve Projections From Auditory Belt and Parabelt to Frontal Cortex T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39883802; 4120854 JF - 35th Annual Meeting of the Society for Neuroscience AU - Munoz, M AU - Saunders, R C AU - Mishkin, M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Cortex (temporal) KW - Cortex (frontal) KW - Cortex (auditory) KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39883802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Medial+Temporal+Removals+Preserve+Projections+From+Auditory+Belt+and+Parabelt+to+Frontal+Cortex&rft.au=Munoz%2C+M%3BSaunders%2C+R+C%3BMishkin%2C+M&rft.aulast=Munoz&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Developmental Changes in Visual Selective Attention: Comparison of Children with Healthy Adults T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39883046; 4132933 JF - 35th Annual Meeting of the Society for Neuroscience AU - Friedman-Hill, S R AU - Gex, S E AU - Towbin, K E AU - Pine, D S AU - Leibenluft, E AU - Ungerleider, L G Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Children KW - Attention KW - Visual perception KW - Developmental stages KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39883046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Developmental+Changes+in+Visual+Selective+Attention%3A+Comparison+of+Children+with+Healthy+Adults&rft.au=Friedman-Hill%2C+S+R%3BGex%2C+S+E%3BTowbin%2C+K+E%3BPine%2C+D+S%3BLeibenluft%2C+E%3BUngerleider%2C+L+G&rft.aulast=Friedman-Hill&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activation in the Premotor Cortex During Perceiving Successive Stimuli With or Without Explicit Counting T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39882990; 4132914 JF - 35th Annual Meeting of the Society for Neuroscience AU - Kansaku, K AU - Grillon, M AU - Johnson, A AU - Sadato, N AU - Hallett, M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Enumeration KW - Cortex (premotor) KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39882990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Activation+in+the+Premotor+Cortex+During+Perceiving+Successive+Stimuli+With+or+Without+Explicit+Counting&rft.au=Kansaku%2C+K%3BGrillon%2C+M%3BJohnson%2C+A%3BSadato%2C+N%3BHallett%2C+M&rft.aulast=Kansaku&rft.aufirst=K&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a "Split Transcription Factor" System for Refined Spatial Manipulation of Neuronal Activity in Drosophila T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39882818; 4123528 JF - 35th Annual Meeting of the Society for Neuroscience AU - Luan, H AU - Marsh, J AU - White, B H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Transcription factors KW - Drosophila KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39882818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Development+of+a+%22Split+Transcription+Factor%22+System+for+Refined+Spatial+Manipulation+of+Neuronal+Activity+in+Drosophila&rft.au=Luan%2C+H%3BMarsh%2C+J%3BWhite%2C+B+H&rft.aulast=Luan&rft.aufirst=H&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Antipsychotics on Neural Activation During Reward Anticipation in Schizophrenia T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39882815; 4129776 JF - 35th Annual Meeting of the Society for Neuroscience AU - Wint, D AU - Koch, P AU - Dreher, J AU - Furman, D AU - Kohn, P AU - Egan, M AU - Weinberger, D AU - Berman, K F Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Neuroleptics KW - Schizophrenia KW - Reinforcement KW - Mental disorders KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39882815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effect+of+Antipsychotics+on+Neural+Activation+During+Reward+Anticipation+in+Schizophrenia&rft.au=Wint%2C+D%3BKoch%2C+P%3BDreher%2C+J%3BFurman%2C+D%3BKohn%2C+P%3BEgan%2C+M%3BWeinberger%2C+D%3BBerman%2C+K+F&rft.aulast=Wint&rft.aufirst=D&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Percept - Related Fluctuations of MT Local Field Potentials T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39882314; 4127540 DE: JF - 35th Annual Meeting of the Society for Neuroscience AU - Maier, A V AU - Logothetis, N K AU - Leopold, D A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39882314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Percept+-+Related+Fluctuations+of+MT+Local+Field+Potentials&rft.au=Maier%2C+A+V%3BLogothetis%2C+N+K%3BLeopold%2C+D+A&rft.aulast=Maier&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Negative Reinforcers Activates the Neural Reward Circuitry T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39882252; 4120997 JF - 35th Annual Meeting of the Society for Neuroscience AU - Martin-Soelch, C AU - Herdener, M AU - Kandzia, W AU - Scheffler, K AU - Seifritz, E Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Reinforcement KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39882252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Negative+Reinforcers+Activates+the+Neural+Reward+Circuitry&rft.au=Martin-Soelch%2C+C%3BHerdener%2C+M%3BKandzia%2C+W%3BScheffler%2C+K%3BSeifritz%2C+E&rft.aulast=Martin-Soelch&rft.aufirst=C&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prefrontal Mechanisms for Abstract Response Strategies T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39882246; 4120862 DE: JF - 35th Annual Meeting of the Society for Neuroscience AU - Genovesio, A AU - Brasted, P J AU - Mitz, A R AU - Wise, S P Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39882246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Prefrontal+Mechanisms+for+Abstract+Response+Strategies&rft.au=Genovesio%2C+A%3BBrasted%2C+P+J%3BMitz%2C+A+R%3BWise%2C+S+P&rft.aulast=Genovesio&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Investigating the Neural Basis of Psychophysiological Interactions in fMRI T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39882155; 4120835 JF - 35th Annual Meeting of the Society for Neuroscience AU - Kim, J AU - Horwitz, B Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Functional magnetic resonance imaging KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39882155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Investigating+the+Neural+Basis+of+Psychophysiological+Interactions+in+fMRI&rft.au=Kim%2C+J%3BHorwitz%2C+B&rft.aulast=Kim&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Depletion of Chromogranin A by Antisense RNAs Leads to Abnormal Chromaffin Granule Biogenesis in Transgenic Mice T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39882016; 4134135 JF - 35th Annual Meeting of the Society for Neuroscience AU - Kim, T AU - Zhang, C F AU - Sun, Z AU - Wu, H. AU - Loh, Y P Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Mice KW - Antisense RNA KW - Chromogranins KW - Evolution KW - Transgenic mice KW - Chromaffin granules KW - Biogenesis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39882016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Depletion+of+Chromogranin+A+by+Antisense+RNAs+Leads+to+Abnormal+Chromaffin+Granule+Biogenesis+in+Transgenic+Mice&rft.au=Kim%2C+T%3BZhang%2C+C+F%3BSun%2C+Z%3BWu%2C+H.%3BLoh%2C+Y+P&rft.aulast=Kim&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Calcium Influx Through Postsynaptic AMPA Receptors Elicits GABA Release at a Reciprocal Synapse of Rat Retina T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39881327; 4127271 JF - 35th Annual Meeting of the Society for Neuroscience AU - Chavez, A E AU - Diamond, J S Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Retina KW - ^a-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors KW - Calcium influx KW - Synapses KW - ^g-Aminobutyric acid KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39881327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Calcium+Influx+Through+Postsynaptic+AMPA+Receptors+Elicits+GABA+Release+at+a+Reciprocal+Synapse+of+Rat+Retina&rft.au=Chavez%2C+A+E%3BDiamond%2C+J+S&rft.aulast=Chavez&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Myelin - Associated Glycoprotein - Activated Signaling in Oligodendrocytes T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39881175; 4134347 JF - 35th Annual Meeting of the Society for Neuroscience AU - Cheng, S AU - Quarles, R H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Signal transduction KW - Myelin KW - Glycoproteins KW - Oligodendrocytes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39881175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Myelin+-+Associated+Glycoprotein+-+Activated+Signaling+in+Oligodendrocytes&rft.au=Cheng%2C+S%3BQuarles%2C+R+H&rft.aulast=Cheng&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dopamine - - Glutamate Interaction Induces Neuronal Avalanches in Superficial Layers of Rat Prefrontal Cortex T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39880894; 4134285 JF - 35th Annual Meeting of the Society for Neuroscience AU - Stewart, C V AU - Gerfen, C AU - Plenz, D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Avalanches KW - Glutamic acid KW - Cortex (prefrontal) KW - Dopamine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39880894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Dopamine+-+-+Glutamate+Interaction+Induces+Neuronal+Avalanches+in+Superficial+Layers+of+Rat+Prefrontal+Cortex&rft.au=Stewart%2C+C+V%3BGerfen%2C+C%3BPlenz%2C+D&rft.aulast=Stewart&rft.aufirst=C&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neural Correlates of Regional Electroencephalogram Power Change T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39880809; 4134255 JF - 35th Annual Meeting of the Society for Neuroscience AU - Oishi, N AU - Mima, T AU - Ishii, K AU - Bushara, K O AU - Hiraoka, T AU - Ueki, Y AU - Fukuyama, H AU - Hallett, M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - EEG KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39880809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neural+Correlates+of+Regional+Electroencephalogram+Power+Change&rft.au=Oishi%2C+N%3BMima%2C+T%3BIshii%2C+K%3BBushara%2C+K+O%3BHiraoka%2C+T%3BUeki%2C+Y%3BFukuyama%2C+H%3BHallett%2C+M&rft.aulast=Oishi&rft.aufirst=N&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Kinetic and Metabolic Evaluation of New PET Ligands for Peripheral Benzodiazepine Receptors T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39880363; 4126872 JF - 35th Annual Meeting of the Society for Neuroscience AU - Imaizumi, M AU - Briard, E AU - Zoghbi, S S AU - Hong, J AU - Shah, J AU - Musachio, J L AU - Pike, V W AU - Innis, R B AU - Fujita, M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Kinetics KW - Benzodiazepine receptors KW - Ligands KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39880363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Kinetic+and+Metabolic+Evaluation+of+New+PET+Ligands+for+Peripheral+Benzodiazepine+Receptors&rft.au=Imaizumi%2C+M%3BBriard%2C+E%3BZoghbi%2C+S+S%3BHong%2C+J%3BShah%2C+J%3BMusachio%2C+J+L%3BPike%2C+V+W%3BInnis%2C+R+B%3BFujita%2C+M&rft.aulast=Imaizumi&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Further Evidence Supporting Glycogen Synthase Kinase - 3 and b - Catenin as Mediators of the Behavioral Effects of Lithium T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39880289; 4121780 JF - 35th Annual Meeting of the Society for Neuroscience AU - Gould, T D AU - Einat, H AU - Picchini, A M AU - Bhat, R AU - Eberthart, C G AU - Schloesser, R J AU - Manji, H K Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Lithium KW - Catenin KW - Glycogen synthase kinase 3 KW - Glycogen KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39880289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Further+Evidence+Supporting+Glycogen+Synthase+Kinase+-+3+and+b+-+Catenin+as+Mediators+of+the+Behavioral+Effects+of+Lithium&rft.au=Gould%2C+T+D%3BEinat%2C+H%3BPicchini%2C+A+M%3BBhat%2C+R%3BEberthart%2C+C+G%3BSchloesser%2C+R+J%3BManji%2C+H+K&rft.aulast=Gould&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Decision - Making Processes During Potential Reward and Punishment: An fMRI Study T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39880285; 4133217 JF - 35th Annual Meeting of the Society for Neuroscience AU - Hardin, M G AU - Pine, D S AU - Ernst, M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Reinforcement KW - Punishment KW - Functional magnetic resonance imaging KW - Decision making KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39880285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Decision+-+Making+Processes+During+Potential+Reward+and+Punishment%3A+An+fMRI+Study&rft.au=Hardin%2C+M+G%3BPine%2C+D+S%3BErnst%2C+M&rft.aulast=Hardin&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nucleotide Sequence Variation Within the Human Tyrosine Kinase B Neurotrophin Receptor Gene ( NTRK2 ) is Associated with Alcohol Dependence and Alcohol Abuse T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39879960; 4133681 JF - 35th Annual Meeting of the Society for Neuroscience AU - Xu, K. AU - Anderson, T R AU - Neyer, K M AU - Lamparella, N AU - Jenkins, G AU - Zhou, Z AU - Lipsky, R H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Alcohols KW - Protein-tyrosine kinase KW - Neurotrophin receptors KW - Drug abuse KW - Drug dependence KW - Nucleotide sequence KW - Tyrosine KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39879960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Nucleotide+Sequence+Variation+Within+the+Human+Tyrosine+Kinase+B+Neurotrophin+Receptor+Gene+%28+NTRK2+%29+is+Associated+with+Alcohol+Dependence+and+Alcohol+Abuse&rft.au=Xu%2C+K.%3BAnderson%2C+T+R%3BNeyer%2C+K+M%3BLamparella%2C+N%3BJenkins%2C+G%3BZhou%2C+Z%3BLipsky%2C+R+H&rft.aulast=Xu&rft.aufirst=K.&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Two Critical Stages of Late - phase Long - term Potentiation (L - LTP) Mediated by BDNF with Distinct Mechanisms T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39879565; 4130800 JF - 35th Annual Meeting of the Society for Neuroscience AU - Pang, P T AU - Yung, W H AU - Lu, B. Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Long-term potentiation KW - Brain-derived neurotrophic factor KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39879565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Two+Critical+Stages+of+Late+-+phase+Long+-+term+Potentiation+%28L+-+LTP%29+Mediated+by+BDNF+with+Distinct+Mechanisms&rft.au=Pang%2C+P+T%3BYung%2C+W+H%3BLu%2C+B.&rft.aulast=Pang&rft.aufirst=P&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distribution of Scaffolding Molecules at the Postsynaptic Density T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39878913; 4119712 JF - 35th Annual Meeting of the Society for Neuroscience AU - DeGiorgis, J A AU - Dosemeci, A AU - Reese, T S Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Postsynaptic density KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39878913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Distribution+of+Scaffolding+Molecules+at+the+Postsynaptic+Density&rft.au=DeGiorgis%2C+J+A%3BDosemeci%2C+A%3BReese%2C+T+S&rft.aulast=DeGiorgis&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single Nucleotide Polymorphisms ( SNPs ) in NRG1 Affect Nicotinic Acetylcholine Receptor ( nAChR ) a7 Subunit Expression T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39878207; 4130104 JF - 35th Annual Meeting of the Society for Neuroscience AU - Mathew, S V AU - Hyde, T M AU - Lipska, B K AU - Vakkalanka, R AU - Straub, R E AU - Weinberger, D R AU - Kleinman, J E Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Acetylcholine receptors (nicotinic) KW - Single-nucleotide polymorphism KW - Neurotransmitters KW - Nucleotides KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39878207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Single+Nucleotide+Polymorphisms+%28+SNPs+%29+in+NRG1+Affect+Nicotinic+Acetylcholine+Receptor+%28+nAChR+%29+a7+Subunit+Expression&rft.au=Mathew%2C+S+V%3BHyde%2C+T+M%3BLipska%2C+B+K%3BVakkalanka%2C+R%3BStraub%2C+R+E%3BWeinberger%2C+D+R%3BKleinman%2C+J+E&rft.aulast=Mathew&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dysregulation of the Brain Stress System and Propensity to Relapse in Genetically Selected Alcohol Preferring msP Rats T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39877938; 4130173 JF - 35th Annual Meeting of the Society for Neuroscience AU - Hansson, A C AU - Cippitelli, A AU - Sommer, W H AU - Fideli, A AU - Massi, M AU - Heilig, M AU - Ciccocioppo, R Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Alcohols KW - Stress KW - Brain KW - Rats KW - Ethanol KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39877938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Dysregulation+of+the+Brain+Stress+System+and+Propensity+to+Relapse+in+Genetically+Selected+Alcohol+Preferring+msP+Rats&rft.au=Hansson%2C+A+C%3BCippitelli%2C+A%3BSommer%2C+W+H%3BFideli%2C+A%3BMassi%2C+M%3BHeilig%2C+M%3BCiccocioppo%2C+R&rft.aulast=Hansson&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Function of Alternatively Spliced Nonmuscle Myosin II - B Isoforms in Mouse Brain Development T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39877816; 4130444 JF - 35th Annual Meeting of the Society for Neuroscience AU - Ma, X. AU - Kawamoto, S AU - Bridgman, P C AU - Uribe, J A AU - Adelstein, R S Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Brain KW - Myosin KW - Alternative splicing KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39877816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Function+of+Alternatively+Spliced+Nonmuscle+Myosin+II+-+B+Isoforms+in+Mouse+Brain+Development&rft.au=Ma%2C+X.%3BKawamoto%2C+S%3BBridgman%2C+P+C%3BUribe%2C+J+A%3BAdelstein%2C+R+S&rft.aulast=Ma&rft.aufirst=X.&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vanilloid - Evoked Calcium Responses from Embryonic Cortical Neurons in Primary Culture T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39877240; 4125788 JF - 35th Annual Meeting of the Society for Neuroscience AU - Csermely, T AU - Mitchell, K AU - Keller, J AU - Karai, L AU - Iadarola, M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Calcium KW - Embryos KW - Cortex KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39877240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Vanilloid+-+Evoked+Calcium+Responses+from+Embryonic+Cortical+Neurons+in+Primary+Culture&rft.au=Csermely%2C+T%3BMitchell%2C+K%3BKeller%2C+J%3BKarai%2C+L%3BIadarola%2C+M&rft.aulast=Csermely&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Shifting Visual Receptive Fields in the Frontal Eye Field: Do they Use Corollary Discharge from the Thalamus? T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39877221; 4119673 JF - 35th Annual Meeting of the Society for Neuroscience AU - Sommer, M A AU - Wurtz, R H Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Eye KW - Thalamus KW - Receptive field KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39877221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Shifting+Visual+Receptive+Fields+in+the+Frontal+Eye+Field%3A+Do+they+Use+Corollary+Discharge+from+the+Thalamus%3F&rft.au=Sommer%2C+M+A%3BWurtz%2C+R+H&rft.aulast=Sommer&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activation of Dopamine D@@d1@, Not D@@d5@, Receptors Facilitates Extinction of Fear Memories in Mice T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39876816; 4128065 JF - 35th Annual Meeting of the Society for Neuroscience AU - Izquierdo, A AU - Cabrera, D M AU - Sibley, D R AU - Holmes, A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Mice KW - Dopamine D5 receptors KW - Extinction KW - Fear KW - Dopamine D1 receptors KW - Memory KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39876816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Activation+of+Dopamine+D%40%40d1%40%2C+Not+D%40%40d5%40%2C+Receptors+Facilitates+Extinction+of+Fear+Memories+in+Mice&rft.au=Izquierdo%2C+A%3BCabrera%2C+D+M%3BSibley%2C+D+R%3BHolmes%2C+A&rft.aulast=Izquierdo&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Additive Effects of Endogenous Cannabinoid Anandamide and Halothane on a7 - Nicotinic Acetylcholine Receptor - Mediated Responses in Xenopus Oocytes T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39876697; 4133972 JF - 35th Annual Meeting of the Society for Neuroscience AU - Zhang, L AU - Oz, M. AU - Jackson, S N AU - Woods, A S AU - Morales, M Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Additives KW - Anandamide KW - Oocytes KW - Acetylcholine receptors (nicotinic) KW - Halothane KW - Neurotransmitters KW - Amphibiotic species KW - Xenopus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39876697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Additive+Effects+of+Endogenous+Cannabinoid+Anandamide+and+Halothane+on+a7+-+Nicotinic+Acetylcholine+Receptor+-+Mediated+Responses+in+Xenopus+Oocytes&rft.au=Zhang%2C+L%3BOz%2C+M.%3BJackson%2C+S+N%3BWoods%2C+A+S%3BMorales%2C+M&rft.aulast=Zhang&rft.aufirst=L&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Patterns of NMDAR 2C Subunit Expression Revealed Using b - Gal Knock - in Mice T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39876550; 4127134 JF - 35th Annual Meeting of the Society for Neuroscience AU - Karavanova, I AU - Vasudevan, K AU - Buonanno, A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Mice KW - Glutamic acid receptors KW - N-Methyl-D-aspartic acid receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39876550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Novel+Patterns+of+NMDAR+2C+Subunit+Expression+Revealed+Using+b+-+Gal+Knock+-+in+Mice&rft.au=Karavanova%2C+I%3BVasudevan%2C+K%3BBuonanno%2C+A&rft.aulast=Karavanova&rft.aufirst=I&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activity - Dependent Interaction between Axons and Astrocytes Promotes CNS Myelination T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39876080; 4124081 JF - 35th Annual Meeting of the Society for Neuroscience AU - Ishibashi, T AU - Lee, P R AU - Fields, R D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Central nervous system KW - Myelination KW - Astrocytes KW - Axons KW - Neurons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39876080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Activity+-+Dependent+Interaction+between+Axons+and+Astrocytes+Promotes+CNS+Myelination&rft.au=Ishibashi%2C+T%3BLee%2C+P+R%3BFields%2C+R+D&rft.aulast=Ishibashi&rft.aufirst=T&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vasopressin Mediates Pituitary Mitogenesis but not Increases in the Number of ACTH Containing Corticotrophs T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39875864; 4129420 JF - 35th Annual Meeting of the Society for Neuroscience AU - Subburaju, S AU - Zeise, M AU - Aguilera, G Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Adrenocorticotropic hormone KW - Pituitary KW - Vasopressin KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39875864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Vasopressin+Mediates+Pituitary+Mitogenesis+but+not+Increases+in+the+Number+of+ACTH+Containing+Corticotrophs&rft.au=Subburaju%2C+S%3BZeise%2C+M%3BAguilera%2C+G&rft.aulast=Subburaju&rft.aufirst=S&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Imaging the Effects of Levodopa on Motor Memory Formation with 11 - C - Raclopride PET in Healthy Elderly Subjects T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39874856; 4118998 JF - 35th Annual Meeting of the Society for Neuroscience AU - Floel, A AU - Garraux, G AU - Breitenstein, C AU - Herscovitch, P AU - Knecht, S AU - Cohen, L G Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Elderly KW - Levodopa KW - Raclopride KW - Geriatrics KW - Memory KW - Imaging techniques KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39874856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Imaging+the+Effects+of+Levodopa+on+Motor+Memory+Formation+with+11+-+C+-+Raclopride+PET+in+Healthy+Elderly+Subjects&rft.au=Floel%2C+A%3BGarraux%2C+G%3BBreitenstein%2C+C%3BHerscovitch%2C+P%3BKnecht%2C+S%3BCohen%2C+L+G&rft.aulast=Floel&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Modeling Study of the Human P2Y@@d2@ Receptor Agonists T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39873747; 4125435 JF - 35th Annual Meeting of the Society for Neuroscience AU - Ivanov, A A AU - Costanzi, S AU - Jacobson, K A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Purine P2Y receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39873747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Molecular+Modeling+Study+of+the+Human+P2Y%40%40d2%40+Receptor+Agonists&rft.au=Ivanov%2C+A+A%3BCostanzi%2C+S%3BJacobson%2C+K+A&rft.aulast=Ivanov&rft.aufirst=A&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Time - Course Changes of Dopamine D@@d2@ and CB1 Cannabinoid Receptors During Cocaine Self - Administration T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39872810; 4128482 JF - 35th Annual Meeting of the Society for Neuroscience AU - Thanos, P K AU - Soria, L AU - Michaelides, M E AU - Piyis, Y K AU - Pappas, G P AU - Maldonado, R AU - Valverde, O AU - Volkow, N D Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Cocaine KW - Cannabinoid CB1 receptors KW - Dopamine D2 receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39872810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Time+-+Course+Changes+of+Dopamine+D%40%40d2%40+and+CB1+Cannabinoid+Receptors+During+Cocaine+Self+-+Administration&rft.au=Thanos%2C+P+K%3BSoria%2C+L%3BMichaelides%2C+M+E%3BPiyis%2C+Y+K%3BPappas%2C+G+P%3BMaldonado%2C+R%3BValverde%2C+O%3BVolkow%2C+N+D&rft.aulast=Thanos&rft.aufirst=P&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo and In Vitro Measurement of Brain Phosphodiesterase 4 in Rats after Antidepressant Treatment T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39872242; 4119892 JF - 35th Annual Meeting of the Society for Neuroscience AU - Fujita, M AU - Imaizumi, M AU - D'Sa, C AU - Zoghbi, S S AU - Crescenzo, M S AU - Hong, J AU - Musachio, J L AU - Gee, A D AU - Seidel, J AU - Green, M V AU - Pike, V W AU - Duman, R S AU - Innis, R B Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Antidepressants KW - Brain KW - Rats KW - Phosphodiesterase IV KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39872242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=In+Vivo+and+In+Vitro+Measurement+of+Brain+Phosphodiesterase+4+in+Rats+after+Antidepressant+Treatment&rft.au=Fujita%2C+M%3BImaizumi%2C+M%3BD%27Sa%2C+C%3BZoghbi%2C+S+S%3BCrescenzo%2C+M+S%3BHong%2C+J%3BMusachio%2C+J+L%3BGee%2C+A+D%3BSeidel%2C+J%3BGreen%2C+M+V%3BPike%2C+V+W%3BDuman%2C+R+S%3BInnis%2C+R+B&rft.aulast=Fujita&rft.aufirst=M&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sulcal Morphometry in Williams Syndrome T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39870781; 4126098 JF - 35th Annual Meeting of the Society for Neuroscience AU - Kippenhan, J S AU - Meyer-Lindenberg, A AU - Olsen, R K AU - Mervis, C B AU - Morris, C A AU - Kohn, P D AU - Berman, K F Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Williams syndrome KW - Morphometry KW - Animal morphology KW - Symptoms KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39870781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Sulcal+Morphometry+in+Williams+Syndrome&rft.au=Kippenhan%2C+J+S%3BMeyer-Lindenberg%2C+A%3BOlsen%2C+R+K%3BMervis%2C+C+B%3BMorris%2C+C+A%3BKohn%2C+P+D%3BBerman%2C+K+F&rft.aulast=Kippenhan&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Shifting Visual Receptive Fields in the Frontal Eye Field: Do they Spread or do they Jump? T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39868971; 4119672 JF - 35th Annual Meeting of the Society for Neuroscience AU - Wurtz, R H AU - Sommer, M A Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Eye KW - Receptive field KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39868971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Shifting+Visual+Receptive+Fields+in+the+Frontal+Eye+Field%3A+Do+they+Spread+or+do+they+Jump%3F&rft.au=Wurtz%2C+R+H%3BSommer%2C+M+A&rft.aulast=Wurtz&rft.aufirst=R&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Menstrual Cycle Phase Modulates the Reward System in Women T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39868730; 4121005 JF - 35th Annual Meeting of the Society for Neuroscience AU - Dreher, J AU - Schmidt, P AU - Kohn, P AU - Furman, D AU - Olsen, R AU - Koch, P AU - Rubinow, D AU - Berman, K Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Menstrual cycle KW - Reinforcement KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39868730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Menstrual+Cycle+Phase+Modulates+the+Reward+System+in+Women&rft.au=Dreher%2C+J%3BSchmidt%2C+P%3BKohn%2C+P%3BFurman%2C+D%3BOlsen%2C+R%3BKoch%2C+P%3BRubinow%2C+D%3BBerman%2C+K&rft.aulast=Dreher&rft.aufirst=J&rft.date=2005-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://sfn.scholarone.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Respective Contributions of Two Negative Feedback Mechanisms in Neuronal Rhythms T2 - 35th Annual Meeting of the Society for Neuroscience AN - 39867443; 4124004 JF - 35th Annual Meeting of the Society for Neuroscience AU - Tabak, J AU - Rinzel, J Y1 - 2005/11/12/ PY - 2005 DA - 2005 Nov 12 KW - Feedback KW - Rhythms KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39867443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=35th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Respective+Contributions+of+Two+Negative+Feedback+Mechanisms+