TY - JOUR T1 - Significant prostate-specific antigen (PSA) response to low-dose ketoconazole in a patient with non-metastatic androgen-independent prostate cancer (AIPC) and a review of the literature. AN - 70536501; 17515709 AB - Although there are a variety of treatment options for nonmetastatic androgen-independent prostate cancer (AIPC), they have limited benefits. Currently, no standard of care exists for this population. Ultimately, sequential therapeutics can be used to minimize symptomatic progression and control the underlying disease, as determined by prostate-specific antigen (PSA) levels. We report here a 90-year-old patient who had PSA progression after multiple previous treatments and was started on ketoconazole 200 mg, three times daily. His serum PSA levels dropped 84% in less than a year on therapy. A literature review yields several studies that support the benefits of ketoconazole as noted by PSA reduction and correlates these responses with survival benefits. The literature also suggests that low-dose ketoconazole may be an appropriate second- or third-line hormonal agent in AIPC, causing a PSA decline, symptomatic relief, and minimal toxicity. JF - American journal of therapeutics AU - Madan, Ravi A AU - Lieberman, Ron AU - Gulley, James L AU - Dahut, William AU - Arlen, Philip M AD - Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-1750, USA. arlenp@mail.nih.gov PY - 2007 SP - 310 EP - 313 VL - 14 IS - 3 SN - 1075-2765, 1075-2765 KW - Prostate-Specific Antigen KW - EC 3.4.21.77 KW - Ketoconazole KW - R9400W927I KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Aged, 80 and over KW - Humans KW - Male KW - Ketoconazole -- therapeutic use KW - Prostate-Specific Antigen -- blood KW - Prostatic Neoplasms -- classification KW - Prostatic Neoplasms -- drug therapy KW - Prostate-Specific Antigen -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70536501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+therapeutics&rft.atitle=Significant+prostate-specific+antigen+%28PSA%29+response+to+low-dose+ketoconazole+in+a+patient+with+non-metastatic+androgen-independent+prostate+cancer+%28AIPC%29+and+a+review+of+the+literature.&rft.au=Madan%2C+Ravi+A%3BLieberman%2C+Ron%3BGulley%2C+James+L%3BDahut%2C+William%3BArlen%2C+Philip+M&rft.aulast=Madan&rft.aufirst=Ravi&rft.date=2007-05-01&rft.volume=14&rft.issue=3&rft.spage=310&rft.isbn=&rft.btitle=&rft.title=American+journal+of+therapeutics&rft.issn=10752765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-19 N1 - Date created - 2007-05-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Releasable PEGylation of mesothelin targeted immunotoxin SS1P achieves single dosage complete regression of a human carcinoma in mice. AN - 70506438; 17346030 AB - Recombinant immunotoxins exhibit targeting and cytotoxic functions needed for cell-specific destruction. However, antitumor efficacy, safety, and pharmacokinetics of these therapeutics might be improved by further macromolecular engineering. SS1P is a recombinant anti-mesothelin immunotoxin in clinical trials in patients with mesothelin-expressing tumors. We have modified this immunotoxin using several PEGylation strategies employing releasable linkages between the protein and the PEG polymers, and observed superior performance of these bioconjugates when compared to similar PEG derivatives bearing permanent linkages to the polymers. PEGylated derivatives displayed markedly diminished cytotoxicity on cultured mesothelin-overexpressing A431-K5 cells; however, the releasable PEGylated immunotoxins exhibited increased antitumor activity in A431-K5 xenografts in mice, with a diminished animal toxicity. Most significantly, complete tumor regressions were achievable with single dose administration of the bioconjugates but not the native immunotoxin. Pharmacokinetic analysis of the releasable PEGylated derivatives in mice demonstrated an over 80-fold expansion of the area under the curve exposure of bioactive protein when compared to native immunotoxin. A correlation in degree of derivatization, release kinetics, and polymer size with potency was observed in vivo, whereas in vitro cytotoxicity was not predictive of efficacy in animal models. The potent antitumor efficacy of the releasable PEGylated mesothelin-targeted immunotoxins was not exhibited by similar untargeted PEG immunotoxins in this model. Since the bioconjugates can also exhibit the attributes of passive targeting via enhanced permeability and retention, this is the first demonstration of a pivotal role of active targeting for immunotoxin bioconjugate efficacy. JF - Bioconjugate chemistry AU - Filpula, David AU - Yang, Karen AU - Basu, Amartya AU - Hassan, Raffit AU - Xiang, Laiman AU - Zhang, Zhenfan AU - Wang, Maoliang AU - Wang, Qing-cheng AU - Ho, Mitchell AU - Beers, Richard AU - Zhao, Hong AU - Peng, Ping AU - Zhou, John AU - Li, Xiguang AU - Petti, Gerald AU - Janjua, Ahsen AU - Liu, Jun AU - Wu, Dechun AU - Yu, Deshan AU - Zhang, Zhihua AU - Longley, Clifford AU - FitzGerald, David AU - Kreitman, Robert J AU - Pastan, Ira AD - Enzon Pharmaceuticals, Incorporated, 20 Kingsbridge Road, Piscataway, New Jersey 08854, and Laboratory of Molecular Biology, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. david.filpula@enzon.com PY - 2007 SP - 773 EP - 784 VL - 18 IS - 3 SN - 1043-1802, 1043-1802 KW - Antibodies, Monoclonal KW - 0 KW - GPI-Linked Proteins KW - Immunotoxins KW - Membrane Glycoproteins KW - Recombinant Proteins KW - SS1(dsFv)PE38 KW - mesothelin KW - Polyethylene Glycols KW - 30IQX730WE KW - Index Medicus KW - Animals KW - Humans KW - Xenograft Model Antitumor Assays KW - Recombinant Proteins -- pharmacokinetics KW - Mice KW - Recombinant Proteins -- chemistry KW - Mice, Inbred BALB C KW - Recombinant Proteins -- therapeutic use KW - Immunotoxins -- pharmacokinetics KW - Immunotoxins -- chemistry KW - Polyethylene Glycols -- chemistry KW - Antibodies, Monoclonal -- pharmacokinetics KW - Membrane Glycoproteins -- antagonists & inhibitors KW - Carcinoma -- drug therapy KW - Immunotoxins -- therapeutic use KW - Antibodies, Monoclonal -- chemistry KW - Carcinoma -- metabolism KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70506438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioconjugate+chemistry&rft.atitle=Releasable+PEGylation+of+mesothelin+targeted+immunotoxin+SS1P+achieves+single+dosage+complete+regression+of+a+human+carcinoma+in+mice.&rft.au=Filpula%2C+David%3BYang%2C+Karen%3BBasu%2C+Amartya%3BHassan%2C+Raffit%3BXiang%2C+Laiman%3BZhang%2C+Zhenfan%3BWang%2C+Maoliang%3BWang%2C+Qing-cheng%3BHo%2C+Mitchell%3BBeers%2C+Richard%3BZhao%2C+Hong%3BPeng%2C+Ping%3BZhou%2C+John%3BLi%2C+Xiguang%3BPetti%2C+Gerald%3BJanjua%2C+Ahsen%3BLiu%2C+Jun%3BWu%2C+Dechun%3BYu%2C+Deshan%3BZhang%2C+Zhihua%3BLongley%2C+Clifford%3BFitzGerald%2C+David%3BKreitman%2C+Robert+J%3BPastan%2C+Ira&rft.aulast=Filpula&rft.aufirst=David&rft.date=2007-05-01&rft.volume=18&rft.issue=3&rft.spage=773&rft.isbn=&rft.btitle=&rft.title=Bioconjugate+chemistry&rft.issn=10431802&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-29 N1 - Date created - 2007-05-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Improvement of a recombinant anti-monkey anti-CD3 diphtheria toxin based immunotoxin by yeast display affinity maturation of the scFv. AN - 70493681; 17352456 AB - Recently, a bivalent recombinant anti-human CD3 diphtheria toxin (DT) based immunotoxin derived from the scFv of UCHT1 antibody has been made that shows enhanced bioactivity and is free from the side effects of Fc receptor interaction. In this case, the diminution of CD3 binding due to the placement of the scFv domain at the C-terminus of the truncated DT in single scFv immunotoxins was compensated by adding an additional scFv domain. However, this strategy was less successful for constructing an anti-rhesus recombinant immunotoxin derived from the scFv of FN18 antibody due to poor binding of the anti-rhesus bivalent immunotoxin. We report here that, by increasing the FN18 scFv affinity through random mutagenesis and selection with a dye-labeled monkey CD3epsilongamma recombinant heterodimer, we greatly improved the bioactivity of FN18 derived immunotoxin. The best mutant, C207, contained nine mutations, two of which were located in CDRs that changed the charge from negative to positive. Binding affinity of the C207 scFv to the monkey T cell line HSC-F increased 9.8-fold. The potency of the C207 bivalent immunotoxin assayed by inhibition of protein synthesis increased by 238-fold. JF - Bioconjugate chemistry AU - Wang, Zhirui AU - Kim, Geun-Bae AU - Woo, Jung-Hee AU - Liu, Yuan Yi AU - Mathias, Askale AU - Stavrou, Scott AU - Neville, David M AD - Section on Biophysical Chemistry, Laboratory of Molecular Biology, National Institute of Mental Health, Building 10 Rm 3D46, 10 Center Drive, Bethesda, Maryland 20892-1216, USA. PY - 2007 SP - 947 EP - 955 VL - 18 IS - 3 SN - 1043-1802, 1043-1802 KW - Antigens, CD3 KW - 0 KW - CD3 antigen, gamma chain KW - Codon KW - Diphtheria Toxin KW - Immunoglobulin Variable Region KW - Immunotoxins KW - Recombinant Proteins KW - Rh-Hr Blood-Group System KW - Index Medicus KW - Saccharomyces cerevisiae -- genetics KW - Animals KW - Codon -- genetics KW - Rh-Hr Blood-Group System -- immunology KW - Pichia -- genetics KW - Cells, Cultured KW - Haplorhini -- immunology KW - Dimerization KW - T-Lymphocytes -- drug effects KW - Mutation KW - T-Lymphocytes -- immunology KW - Mutagenesis KW - Immunoglobulin Variable Region -- genetics KW - Recombinant Proteins -- pharmacology KW - Recombinant Proteins -- biosynthesis KW - Immunoglobulin Variable Region -- biosynthesis KW - Antibody Affinity -- immunology KW - Immunotoxins -- metabolism KW - Recombinant Proteins -- genetics KW - Diphtheria Toxin -- genetics KW - Antigens, CD3 -- immunology KW - Immunoglobulin Variable Region -- pharmacology KW - Antibody Affinity -- genetics KW - Diphtheria Toxin -- biosynthesis KW - Diphtheria Toxin -- pharmacology KW - Immunotoxins -- genetics KW - Immunotoxins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70493681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioconjugate+chemistry&rft.atitle=Improvement+of+a+recombinant+anti-monkey+anti-CD3+diphtheria+toxin+based+immunotoxin+by+yeast+display+affinity+maturation+of+the+scFv.&rft.au=Wang%2C+Zhirui%3BKim%2C+Geun-Bae%3BWoo%2C+Jung-Hee%3BLiu%2C+Yuan+Yi%3BMathias%2C+Askale%3BStavrou%2C+Scott%3BNeville%2C+David+M&rft.aulast=Wang&rft.aufirst=Zhirui&rft.date=2007-05-01&rft.volume=18&rft.issue=3&rft.spage=947&rft.isbn=&rft.btitle=&rft.title=Bioconjugate+chemistry&rft.issn=10431802&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-29 N1 - Date created - 2007-05-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pathogen inactivation: the definitive safeguard for the blood supply. AN - 70481662; 17488157 AB - Pathogen inactivation provides a proactive approach to cleansing the blood supply. In the plasma fractionation and manufacturing industry, pathogen inactivation technologies have been successfully implemented resulting in no transmission of human immunodeficiency, hepatitis C, or hepatitis B viruses by US-licensed plasma derivatives since 1985. However, these technologies cannot be used to pathogen inactivate cellular blood components. Although current blood donor screening and disease testing has drastically reduced the incidence of transfusion-transmitted diseases, there still looms the threat to the blood supply of a new or reemerging pathogen. Of particular concern is the silent emergence of a new agent with a prolonged latent period in which asymptomatic infected carriers would donate and spread infection. To review and summarize the principles, challenges, achievements, prospective technologies, and future goals of pathogen inactivation of the blood supply. The current published English-language literature from 1968 through 2006 and a historical landmark article from 1943 are integrated into a review of this subject. The ultimate goal of pathogen inactivation is to maximally reduce the transmission of potential pathogens without significantly compromising the therapeutic efficacy of the cellular and protein constituents of blood. This must be accomplished without introducing toxicities into the blood supply and without causing neoantigen formation and subsequent antibody production. Several promising pathogen inactivation technologies are being developed and clinically tested, and others are currently in use. Pathogen inactivation offers additional layers of protection from infectious agents that threaten the blood supply and has the potential to impact the safety of blood transfusions worldwide. JF - Archives of pathology & laboratory medicine AU - Bryant, Barbara J AU - Klein, Harvey G AD - National Institutes of Health, Warren G. Magnuson Clinical Center, Department of Transfusion Medicine, 10 Center Dr, MSC-1184, Building 10, Room 1C711, Bethesda, MD 20894-1184, USA. bryantb2@cc.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 719 EP - 733 VL - 131 IS - 5 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Blood Banks KW - Blood Donors KW - Communicable Diseases -- transmission KW - Communicable Disease Control -- methods KW - Blood Transfusion -- adverse effects KW - Blood-Borne Pathogens UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70481662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+pathology+%26+laboratory+medicine&rft.atitle=Pathogen+inactivation%3A+the+definitive+safeguard+for+the+blood+supply.&rft.au=Bryant%2C+Barbara+J%3BKlein%2C+Harvey+G&rft.aulast=Bryant&rft.aufirst=Barbara&rft.date=2007-05-01&rft.volume=131&rft.issue=5&rft.spage=719&rft.isbn=&rft.btitle=&rft.title=Archives+of+pathology+%26+laboratory+medicine&rft.issn=1543-2165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-12 N1 - Date created - 2007-05-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevalence, correlates, disability, and comorbidity of DSM-IV drug abuse and dependence in the United States: results from the national epidemiologic survey on alcohol and related conditions. AN - 70470872; 17485608 AB - Current and comprehensive information on the epidemiology of DSM-IV 12-month and lifetime drug use disorders in the United States has not been available. To present detailed information on drug abuse and dependence prevalence, correlates, and comorbidity with other Axis I and II disorders. Face-to-face interviews using the Alcohol Use Disorder and Associated Disabilities Interview Schedule of the National Institute on Alcohol Abuse and Alcoholism in a large representative sample of US adults (N=43093). Twelve-month and lifetime prevalence of drug abuse and dependence and the associated correlates, treatment rates, disability, and comorbidity with other Axis I and II disorders. Prevalences of 12-month and lifetime drug abuse (1.4% and 7.7%, respectively) exceeded rates of drug dependence (0.6% and 2.6%, respectively). Rates of abuse and dependence were generally greater among men, Native Americans, respondents aged 18 to 44 years, those of lower socioeconomic status, those residing in the West, and those who were never married or widowed, separated, or divorced (all P<.05). Associations of drug use disorders with other substance use disorders and antisocial personality disorder were diminished but remained strong when we controlled for psychiatric disorders. Dependence associations with most mood disorders and generalized anxiety disorder also remained significant. Lifetime treatment- or help-seeking behavior was uncommon (8.1%, abuse; 37.9%, dependence) and was not associated with sociodemographic characteristics but was associated with psychiatric comorbidity. Most individuals with drug use disorders have never been treated, and treatment disparities exist among those at high risk, despite substantial disability and comorbidity. Comorbidity of drug use disorders with other substance use disorders and antisocial personality disorder, as well as dependence with mood disorders and generalized anxiety disorder, appears to be due in part to unique factors underlying each pair of these disorders studied. The persistence of low treatment rates despite the availability of effective treatments indicates the need for vigorous educational efforts for the public and professionals. JF - Archives of general psychiatry AU - Compton, Wilson M AU - Thomas, Yonette F AU - Stinson, Frederick S AU - Grant, Bridget F AD - Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-9304, USA. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 566 EP - 576 VL - 64 IS - 5 SN - 0003-990X, 0003-990X KW - Abridged Index Medicus KW - Index Medicus KW - Age Factors KW - Sex Factors KW - Mental Disorders -- epidemiology KW - Humans KW - Indians, North American -- statistics & numerical data KW - Comorbidity KW - Antisocial Personality Disorder -- epidemiology KW - Mental Disorders -- diagnosis KW - Adult KW - Health Surveys KW - Disability Evaluation KW - Antisocial Personality Disorder -- diagnosis KW - Psychiatric Status Rating Scales -- statistics & numerical data KW - Adolescent KW - United States -- epidemiology KW - Male KW - Diagnostic and Statistical Manual of Mental Disorders KW - Female KW - Prevalence KW - Alcohol-Related Disorders -- epidemiology KW - Substance-Related Disorders -- diagnosis KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70470872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=Prevalence%2C+correlates%2C+disability%2C+and+comorbidity+of+DSM-IV+drug+abuse+and+dependence+in+the+United+States%3A+results+from+the+national+epidemiologic+survey+on+alcohol+and+related+conditions.&rft.au=Compton%2C+Wilson+M%3BThomas%2C+Yonette+F%3BStinson%2C+Frederick+S%3BGrant%2C+Bridget+F&rft.aulast=Compton&rft.aufirst=Wilson&rft.date=2007-05-01&rft.volume=64&rft.issue=5&rft.spage=566&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-03 N1 - Date created - 2007-05-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The pituitary tumor-transforming gene promotes angiogenesis in a mouse model of follicular thyroid cancer. AN - 70429478; 17127711 AB - Overexpression of the pituitary tumor-transforming gene (PTTG) has been associated with tumorigenesis. In a mouse model that spontaneously develops follicular thyroid cancer (FTC) with distant metastasis (TRbetaPV mouse), PTTG is overexpressed, similar to human thyroid cancer. To evaluate the role of PTTG in thyroid carcinogenesis, we studied the offspring of TRbetaPV mice with mice lacking PTTG (PTTG(-/-) mice). The thyroids of TRbeta(PV/PV) PTTG(-/-) mice were significantly smaller than TRbeta(PV/PV) mice. Ki-67 staining showed a decrease in thyroid proliferation in TRbeta(PV/PV) PTTG(-/-) mice. Our evaluation of the Rb-E2F pathway, a central mediator of cell growth, found that TRbeta(PV/PV) PTTG(-/-) mice exhibited a decrease in protein levels of phosphorylated Rb along with an elevation of the cdk inhibitor p21. Histological examination documented no difference in FTC occurrence between TRbeta(PV/PV) and TRbeta(PV/PV) PTTG(-/-) mice, which indicates that PTTG removal does not prevent the initiation of FTC. However, TRbeta(PV/PV) PTTG(-/-) mice had a significant decrease in vascular invasion and less development of lung metastasis as they progressively aged. CD31 staining also showed a decrease in vessel density in TRbeta(PV/PV) PTTG(-/-) versus TRbeta(PV/PV) thyroids. Given the decreased vascular invasion in the PTTG knockout mice, we studied genes involved in angiogenesis. Real-time reverse transcription-polymerase chain reaction showed a consistent decrease in pro-angiogenic factors, fibroblast growth factor (FGF2), its receptor FGFR1 and vascular endothelial growth factor. Our results highlight the dual roles of PTTG as a regulator of thyroid growth and contributor to tumor progression. The separation of the pathways regulating cell proliferation, tumor initiation and tumor progression should direct future therapeutic options. JF - Carcinogenesis AU - Kim, Caroline S AU - Ying, Hao AU - Willingham, Mark C AU - Cheng, Sheue-yann AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Room 5128, Bethesda, MD 20892-4264, USA. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 932 EP - 939 VL - 28 IS - 5 SN - 0143-3334, 0143-3334 KW - Neoplasm Proteins KW - 0 KW - Receptors, Thyroid Hormone KW - Securin KW - pituitary tumor-transforming protein 1, human KW - Index Medicus KW - Animals KW - Mice, Mutant Strains KW - Cells, Cultured KW - Humans KW - Thyroid Gland -- growth & development KW - Receptors, Thyroid Hormone -- genetics KW - Disease Progression KW - Disease Models, Animal KW - Mice KW - Cell Proliferation KW - Mice, Knockout KW - Thyroid Neoplasms -- genetics KW - Neovascularization, Pathologic -- genetics KW - Neoplasm Proteins -- genetics KW - Carcinoma, Papillary, Follicular -- blood supply KW - Thyroid Neoplasms -- blood supply KW - Carcinoma, Papillary, Follicular -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70429478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=The+pituitary+tumor-transforming+gene+promotes+angiogenesis+in+a+mouse+model+of+follicular+thyroid+cancer.&rft.au=Kim%2C+Caroline+S%3BYing%2C+Hao%3BWillingham%2C+Mark+C%3BCheng%2C+Sheue-yann&rft.aulast=Kim&rft.aufirst=Caroline&rft.date=2007-05-01&rft.volume=28&rft.issue=5&rft.spage=932&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-09 N1 - Date created - 2007-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antisocial behavioral syndromes and DSM-IV alcohol use disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 70383913; 17391341 AB - Antisocial personality disorder (ASPD), syndromal adult antisocial behavior (AABS) without conduct disorder (CD) before age 15, and CD without progression to ASPD ("CD only") are highly prevalent among adults with alcohol use disorders (AUDs). Among patients in AUD treatment, antisocial behavioral syndromes are associated with more severe AUDs and poorer treatment outcomes. Comparative data concerning associations of antisocial syndromes with clinical characteristics of AUDs and the sociodemographic and clinical correlates of these syndromes among general population adults with AUDs have not previously been available. This study examines prevalences and correlates of antisocial syndromes among adults with lifetime Diagnostic and Statistical Manual--Version IV (DSM-IV) AUDs, and describes associations of these syndromes with clinical characteristics of AUDs, in the general U.S. population. This report is based on the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (n=43,093, response rate=81%). Respondents (n=11,843) with lifetime AUDs were classified according to whether they met criteria for ASPD, AABS, "CD only," or no antisocial syndrome. Correlates of antisocial syndromes were examined using contingency table approaches and normal theory analyses of variance. Associations of antisocial syndromes with clinical characteristics of AUDs, including number of lifetime episodes, duration of longest or only episode, and alcohol consumption during period of heaviest drinking were examined using normal theory and logistic regression. Sociodemographic and clinical correlates of antisocial syndromes among respondents with AUDs were consistent with results from prior studies. Antisocial syndromes were significantly associated with phenomenology of AUDs, particularly ASPD with the most severe clinical presentations. Associations with AABS were similar to but more modest than those with ASPD; those with "CD only" were weaker and less consistent. Patterns of associations between antisocial syndromes and clinical characteristics of AUDs were generally similar between men and women. Antisocial syndromes, particularly ASPD, appear to identify a more pernicious clinical profile of AUDs among adults in the general U.S. population. JF - Alcoholism, clinical and experimental research AU - Goldstein, Risë B AU - Dawson, Deborah A AU - Saha, Tulshi D AU - Ruan, W June AU - Compton, Wilson M AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-9304, USA. goldster@mail.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 814 EP - 828 VL - 31 IS - 5 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Regression Analysis KW - Sex Factors KW - Reproducibility of Results KW - Mental Disorders -- epidemiology KW - Humans KW - Aged KW - Mental Disorders -- psychology KW - Marriage KW - Alcohol Drinking -- epidemiology KW - Comorbidity KW - Income KW - Socioeconomic Factors KW - Education KW - Psychiatric Status Rating Scales KW - Ethnic Groups KW - Adult KW - Family KW - Middle Aged KW - Mood Disorders -- epidemiology KW - Adolescent KW - United States -- epidemiology KW - Mood Disorders -- psychology KW - Female KW - Male KW - Antisocial Personality Disorder -- epidemiology KW - Alcoholism -- epidemiology KW - Antisocial Personality Disorder -- psychology KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70383913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Antisocial+behavioral+syndromes+and+DSM-IV+alcohol+use+disorders%3A+results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Goldstein%2C+Ris%C3%AB+B%3BDawson%2C+Deborah+A%3BSaha%2C+Tulshi+D%3BRuan%2C+W+June%3BCompton%2C+Wilson+M%3BGrant%2C+Bridget+F&rft.aulast=Goldstein&rft.aufirst=Ris%C3%AB&rft.date=2007-05-01&rft.volume=31&rft.issue=5&rft.spage=814&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-22 N1 - Date created - 2007-04-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, México. AN - 70367147; 17272288 AB - The insecticide 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) is still used for disease control in some areas, resulting in high levels of human exposure. The main degradation product of DDT is 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), an antiandrogen. In animal experiments, in utero exposure to DDE decreases anogenital distance in male offspring. In these models, anogenital distance serves as a measure of fetal androgen action. The authors designed the present study to examine the hypothesis that in utero exposure to DDE decreases anogenital distance in newborn human males. A cross-sectional study of 781 newly delivered male infants was conducted in 2002-2003 in Chiapas, México, where DDT had recently been used for malaria control. Measurements of anogenital distance and penile dimensions were taken, and a sample of the mother's blood was drawn. In this population, the range of serum DDE levels was large (0.8-398 microg/liter). The authors, using two-sided tests, found no evidence that exposure in utero to DDE was related to reduced androgen action as reflected by anogenital distance or penile dimensions at birth. If DDE has important antiandrogenic action in humans, it may be manifest only at higher levels of exposure or via effects on other outcomes. JF - American journal of epidemiology AU - Longnecker, Matthew P AU - Gladen, Beth C AU - Cupul-Uicab, Lea A AU - Romano-Riquer, S Patricia AU - Weber, Jean-Phillipe AU - Chapin, Robert E AU - Hernández-Avila, Mauricio AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC 27709, USA. longnec1@niehs.nih.gov Y1 - 2007/05/01/ PY - 2007 DA - 2007 May 01 SP - 1015 EP - 1022 VL - 165 IS - 9 SN - 0002-9262, 0002-9262 KW - Androgen Antagonists KW - 0 KW - Dichlorodiphenyl Dichloroethylene KW - 4M7FS82U08 KW - DDT KW - CIW5S16655 KW - Index Medicus KW - Humans KW - Infant, Newborn KW - Risk Assessment KW - Pregnancy KW - Cross-Sectional Studies KW - Developmental Biology KW - Maternal-Fetal Exchange KW - Risk Factors KW - Adult KW - Incidence KW - Mexico -- epidemiology KW - Adolescent KW - Time Factors KW - Female KW - Male KW - Maternal Exposure -- adverse effects KW - Androgen Antagonists -- toxicity KW - Urogenital Abnormalities -- epidemiology KW - Genitalia, Male -- drug effects KW - Endocrine System Diseases -- chemically induced KW - Genitalia, Male -- abnormalities KW - DDT -- toxicity KW - Urogenital Abnormalities -- chemically induced KW - Dichlorodiphenyl Dichloroethylene -- toxicity KW - Endocrine System Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70367147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=In+utero+exposure+to+the+antiandrogen+1%2C1-dichloro-2%2C2-bis%28p-chlorophenyl%29ethylene+%28DDE%29+in+relation+to+anogenital+distance+in+male+newborns+from+Chiapas%2C+M%C3%A9xico.&rft.au=Longnecker%2C+Matthew+P%3BGladen%2C+Beth+C%3BCupul-Uicab%2C+Lea+A%3BRomano-Riquer%2C+S+Patricia%3BWeber%2C+Jean-Phillipe%3BChapin%2C+Robert+E%3BHern%C3%A1ndez-Avila%2C+Mauricio&rft.aulast=Longnecker&rft.aufirst=Matthew&rft.date=2007-05-01&rft.volume=165&rft.issue=9&rft.spage=1015&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-31 N1 - Date created - 2007-04-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Androl. 2006 Jan-Feb;27(1):16-27 [16400073] Am J Epidemiol. 2005 Oct 15;162(8):726-8 [16120697] Paediatr Perinat Epidemiol. 2007 May;21(3):219-28 [17439530] Reprod Toxicol. 1999 Sep-Oct;13(5):383-90 [10560587] Pediatrics. 2000 Jul;106(1 Pt 1):138-42 [10878165] Epidemiology. 2001 May;12(3):366-7 [11338320] Am J Epidemiol. 2002 Feb 15;155(4):313-22 [11836195] Toxicology. 2002 May 24;174(2):69-78 [11985884] Epidemiology. 2002 Jul;13(4):454-8 [12094101] Sci Total Environ. 2002 Oct 21;298(1-3):45-53 [12449328] Sci Total Environ. 2003 Jan 20;302(1-3):27-52 [12526896] Toxicol Sci. 2003 Aug;74(2):393-406 [12773767] Int J Hyg Environ Health. 2003 Aug;206(4-5):387-94 [12971694] Salud Publica Mex. 2003 Nov-Dec;45(6):431-8 [14974286] Environ Res. 2004 Sep;96(1):1-8 [15261778] J Pediatr. 1978 Jul;93(1):120-2 [650322] Am J Public Health. 1986 Feb;76(2):172-7 [3080910] Arch Environ Contam Toxicol. 1989 Jul-Aug;18(4):495-500 [2505694] J Anal Toxicol. 1990 Sep-Oct;14(5):301-4 [2263064] J Toxicol Environ Health. 1991 Jun;33(2):141-55 [2051491] Am J Epidemiol. 2005 Oct 15;162(8):709-16 [16120699] Nature. 1995 Jun 15;375(6532):581-5 [7791873] Cancer Epidemiol Biomarkers Prev. 2005 Sep;14(9):2224-36 [16172236] Lancet. 2005 Aug 27-Sep 2;366(9487):763-73 [16125595] Horm Res. 2005;64(1):39-45 [16088206] Environ Health Perspect. 2005 Aug;113(8):1056-61 [16079079] Environ Health. 2004;3(1):8 [15363098] Environ Health Perspect. 2005 Feb;113(2):220-4 [15687061] Environ Res. 2005 Feb;97(2):127-33 [15533328] Toxicol Ind Health. 1999 Jan-Mar;15(1-2):94-118 [10188194] Arch Environ Health. 1999 Mar-Apr;54(2):110-4 [10094288] Toxicol Sci. 1998 Oct;45(2):162-73 [9848123] Environ Res. 2006 Jul;101(3):387-94 [16352301] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neurobiology of HIV, psychiatric and substance abuse comorbidity research: workshop report. AN - 70362968; 17346925 AB - Viral infections can cause persistent and progressive changes in emotional and cognitive functions. The viral-induced imbalances in neuronal network functioning may precipitate or accentuate psychiatric conditions in vulnerable individuals, in part, as a function of the host response to proinflammatory cytokines resulting from infection or brain injury. Research indicates that the mediators of psychiatric illnesses and HIV-neuropathogenesis utilize similar brain structures, neurocircuitry and receptor systems. The genetic, cellular and molecular mechanisms contributing to HIV neuropathogenesis and its late stage clinical correlate, HIV-associated-dementia (HAD), are active areas of neuroAIDS research. The study of HIV in the context of psychiatric comorbidities and comorbid pathogenesis is in a fledgling stage despite epidemiological studies suggesting that >60% of HIV infected individuals will suffer from at least one major psychiatric disorder during the course of infection. Depression is the primary comorbid disorder but anxiety and substance abuse disorders are also considerable in certain HIV(+) populations. Certain substances of abuse and the biological mediators of psychiatric illnesses reportedly interact in the brain and presumptively worsen HIV-related neuropathogenesis and survival measures. A panel of experts discussed approaches for studying the neuroscience of HIV and psychiatric comorbidity at a basic, mechanistic level since they co-exist in high proportion in the human population. Recommended approaches ranged from improving human consent forms and maximizing the value of repository resources to novel research designs and identifying human and animal endophenotypes. JF - Brain, behavior, and immunity AU - Kopnisky, Kathy L AU - Bao, Jing AU - Lin, Yu Woody AD - HIV Therapeutics/Clinical Trials and Psychiatric Pathogenesis Program, Center for Mental Health Research on AIDS, NIH/National Institute of Mental Health, 6001 Executive Blvd/Room 6205 MSC 9619, Rockville, MD 20852, USA. kkopnisk@mail.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 428 EP - 441 VL - 21 IS - 4 SN - 0889-1591, 0889-1591 KW - Index Medicus KW - Brain -- physiopathology KW - Neurobiology KW - Humans KW - Brain -- virology KW - Substance-Related Disorders -- physiopathology KW - HIV Infections -- physiopathology KW - Mental Disorders -- immunology KW - HIV Infections -- complications KW - HIV Infections -- immunology KW - Substance-Related Disorders -- complications KW - Neuroimmunomodulation -- immunology KW - Substance-Related Disorders -- immunology KW - Mental Disorders -- complications KW - Mental Disorders -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70362968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain%2C+behavior%2C+and+immunity&rft.atitle=Neurobiology+of+HIV%2C+psychiatric+and+substance+abuse+comorbidity+research%3A+workshop+report.&rft.au=Kopnisky%2C+Kathy+L%3BBao%2C+Jing%3BLin%2C+Yu+Woody&rft.aulast=Kopnisky&rft.aufirst=Kathy&rft.date=2007-05-01&rft.volume=21&rft.issue=4&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=Brain%2C+behavior%2C+and+immunity&rft.issn=08891591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-17 N1 - Date created - 2007-04-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hobbies with solvent exposure and risk of non-Hodgkin lymphoma. AN - 70264963; 17262168 AB - Occupational exposure to solvents has been reported to increase non-Hodgkin lymphoma (NHL) risk in some, but not all, studies. In a population-based case-control study, we examined whether participation in selected hobbies involving solvent exposure increases NHL risk. We identified NHL cases diagnosed at ages 20-74 years between 1998 and 2000 in Iowa or metropolitan Los Angeles, Detroit, and Seattle. Controls were selected using random digit dialing or Medicare files. Computer-assisted personal interviews (551 cases, 462 controls) elicited data on model building, painting/silkscreening/artwork, furniture refinishing, and woodworking/home carpentry. Hobby participation (68% of cases, 69% of controls) was not associated with NHL risk (OR = 0.9, 95% CI = 0.7-1.2). Compared to people with none of the hobbies evaluated, those who built models had significantly lower risk (OR = 0.7, CI = 0.5-1.0), but risk did not vary with the number of years or lifetime hours. Risk estimates for the other hobbies were generally less than one, but the associations were not significant and there were no notable patterns with duration of exposure. Use of oil-based, acrylic, or water-based paints; paint strippers; polyurethane; or varnishes was not associated with NHL risk. We conclude that participation in hobbies involving exposure to organic solvents is unlikely to increase NHL risk. JF - Cancer causes & control : CCC AU - Colt, Joanne S AU - Hartge, Patricia AU - Davis, Scott AU - Cerhan, James R AU - Cozen, Wendy AU - Severson, Richard K AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. coltj@mail.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 385 EP - 390 VL - 18 IS - 4 SN - 0957-5243, 0957-5243 KW - Environmental Pollutants KW - 0 KW - Solvents KW - Index Medicus KW - Washington -- epidemiology KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - California -- epidemiology KW - Michigan -- epidemiology KW - Male KW - Iowa -- epidemiology KW - Female KW - Risk Assessment KW - Lymphoma, Non-Hodgkin -- epidemiology KW - Solvents -- toxicity KW - Recreation KW - Hobbies KW - Environmental Pollutants -- toxicity KW - Lymphoma, Non-Hodgkin -- etiology KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70264963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+causes+%26+control+%3A+CCC&rft.atitle=Hobbies+with+solvent+exposure+and+risk+of+non-Hodgkin+lymphoma.&rft.au=Colt%2C+Joanne+S%3BHartge%2C+Patricia%3BDavis%2C+Scott%3BCerhan%2C+James+R%3BCozen%2C+Wendy%3BSeverson%2C+Richard+K&rft.aulast=Colt&rft.aufirst=Joanne&rft.date=2007-05-01&rft.volume=18&rft.issue=4&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=Cancer+causes+%26+control+%3A+CCC&rft.issn=09575243&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-07 N1 - Date created - 2007-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nonreporting of cannabis use: Predictors and relationship to treatment outcome in methadone maintained patients. AN - 70202841; 16887281 AB - Underreporting of drug use is common and influenced by multiple factors. Cannabis (THC) use nonreporting and its relationship to heroin and cocaine use were investigated in 690 patients enrolled in 25- to 29-week clinical trials of contingency management plus methadone maintenance. Urine specimens and self-reports of drug use were collected 3 times/week. Potential predictors of THC use nonreporting were analyzed by multiple logistic regression; relationships between THC use nonreporting and % cocaine- and opiate-positive urines were analyzed by multiple regression. Compared to non-THC users (n=317), patients with THC-positive urines (n=373) were more likely to be male and have more years of THC use, but were not different on other characteristics. Nonreporting to user ratios were: THC 191/373 (51.2%); opiates 17/686 (2.5%); cocaine 21/681 (3.1%). Predictors of THC use nonreporting were low rate of THC-positive urines during treatment, fewer days of THC use in the last 30 before treatment, African-American race, and absence of antisocial personality disorder. Nonreporting of THC use was associated with significantly greater opiate and cocaine use. Contingency management decreased cocaine use in THC nonreporters to the level of reporters. Nonreporting of THC use is a significant predictor of greater cocaine and heroin use. This association can be eliminated with contingency management therapy. JF - Addictive behaviors AU - Ghitza, Udi E AU - Epstein, David H AU - Preston, Kenzie L AD - Clinical Pharmacology and Therapeutics Branch, Treatment Section Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), 5500 Nathan Shock Drive Baltimore, MD 21224, USA. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 938 EP - 949 VL - 32 IS - 5 SN - 0306-4603, 0306-4603 KW - Analgesics, Opioid KW - 0 KW - Narcotics KW - Dronabinol KW - 7J8897W37S KW - Cocaine KW - I5Y540LHVR KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Administration, Oral KW - Opioid-Related Disorders -- ethnology KW - Cocaine -- urine KW - Cocaine-Related Disorders -- ethnology KW - Humans KW - Opioid-Related Disorders -- rehabilitation KW - African Americans KW - Analgesics, Opioid -- urine KW - Cocaine-Related Disorders -- epidemiology KW - Behavior Therapy -- methods KW - Substance Abuse Detection -- methods KW - Dronabinol -- urine KW - Opioid-Related Disorders -- epidemiology KW - Token Economy KW - European Continental Ancestry Group KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Time Factors KW - Sex Distribution KW - Male KW - Female KW - Marijuana Abuse -- rehabilitation KW - Marijuana Abuse -- ethnology KW - Narcotics -- administration & dosage KW - Marijuana Abuse -- epidemiology KW - Methadone -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70202841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Nonreporting+of+cannabis+use%3A+Predictors+and+relationship+to+treatment+outcome+in+methadone+maintained+patients.&rft.au=Ghitza%2C+Udi+E%3BEpstein%2C+David+H%3BPreston%2C+Kenzie+L&rft.aulast=Ghitza&rft.aufirst=Udi&rft.date=2007-05-01&rft.volume=32&rft.issue=5&rft.spage=938&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-06 N1 - Date created - 2007-02-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Health, justice, and the environment. AN - 68266703; 17845481 AB - In this article, we argue that the scope of bioethical debate concerning justice in health should expand beyond the topic of access to health care and cover such issues as occupational hazards, safe housing, air pollution, water quality, food and drug safety, pest control, public health, childhood nutrition, disaster preparedness, literacy, and many other environmental factors that can cause differences in health. Since society does not have sufficient resources to address all of these environmental factors at one time, it is important to set priorities for bioethical theorizing and policy formation. Two considerations should be used to set these priorities: (1) the impact of the environmental factor on health inequality, and (2) the practicality of addressing the factor. JF - Bioethics AU - Resnik, David B AU - Roman, Gerard AD - National Institute of Environmental Health Sciences, National Institutes of Health, Box 12233, Mail Drop NH 06, Research Triangle Park, NC 27709, USA. resnikd@niehs.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 230 EP - 241 VL - 21 IS - 4 SN - 0269-9702, 0269-9702 KW - Bioethics KW - Index Medicus KW - Humans KW - Male KW - Health Priorities KW - Female KW - Global Health KW - Social Class KW - Health Services Accessibility -- ethics KW - Social Justice -- ethics KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68266703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioethics&rft.atitle=Health%2C+justice%2C+and+the+environment.&rft.au=Resnik%2C+David+B%3BRoman%2C+Gerard&rft.aulast=Resnik&rft.aufirst=David&rft.date=2007-05-01&rft.volume=21&rft.issue=4&rft.spage=230&rft.isbn=&rft.btitle=&rft.title=Bioethics&rft.issn=02699702&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-27 N1 - Date created - 2007-09-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Med Assoc. 2002 Aug;94(8):666-8 [12152921] Am J Bioeth. 2001 Spring;1(2):2-16 [11951872] Med Decis Making. 2001 Mar-Apr;21(2):105-12 [11310943] Public Health Rep. 2002 Sep-Oct;117(5):426-34 [12500958] Dev World Bioeth. 2004 May;4(1):42-57 [15086373] Lancet. 2000 Jul 22;356(9226):330-2 [11071203] Health Care Anal. 2003 Sep;11(3):229-44 [14708935] Am J Bioeth. 2005 Sep-Oct;5(5):W18-9 [16179292] Environ Health Perspect. 2005 May;113(5):A310-7 [15866753] Bioethics. 2004 Nov;18(6):493-514 [15580721] Environ Health Perspect. 2004 Dec;112(17):1645-53 [15579407] Epidemiology. 1999 Sep;10(5):626-31 [10468442] N Engl J Med. 1999 Jun 17;340(24):1914-5 [10369857] Kennedy Inst Ethics J. 1992 Jun;2(2):103-23 [10119317] Prof Ethics. 2003 Fall;11(3):65-82 [15468492] Dev World Bioeth. 2004 May;4(1):76-95 [15086375] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A Longitudinal Study of Adolescents with Perinatally or Transfusion Acquired HIV Infection: Sexual Knowledge, Risk Reduction Self-efficacy and Sexual Behavior AN - 61398835; 200800678 AB - As HIV-positive children are surviving to adolescence and beyond, understanding their HIV knowledge and sexual behavior is critical. Forty HIV+ adolescents/young adults were interviewed twice, approximately 21 months apart (mean age 16.6 and 18.3 years, respectively). Data on demographics, safer sex knowledge, sexual risk behaviors, risk reduction self-efficacy, and Tanner stage were collected. Twenty- eight percent of HIV+ youth at Time 1 and 41% at Time 2 reported being sexually active. HIV transmission/safer sex knowledge was low, increased with age, and both self-efficacy for and actual condom use was relatively high. Secondary prevention messages should be incorporated into routine medical settings. Adapted from the source document. JF - AIDS and Behavior AU - Wiener, Lori S AU - Battles, Haven B AU - Wood, Lauren V AD - HIV/AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10, Pediatric Clinic 1-SE, Room 1-6466, Bethesda, MD 20892, USA wienerl@mail.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 471 EP - 478 PB - Springer, Dordrecht, The Netherlands VL - 11 IS - 3 SN - 1090-7165, 1090-7165 KW - HIV, Adolescents, Knowledge, Sexual behavior, Condoms KW - Condoms KW - Sexual Behavior KW - Risk KW - Acquired Immune Deficiency Syndrome KW - Sex Information KW - Empowerment KW - Adolescents KW - Child Sexual Abuse KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61398835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=A+Longitudinal+Study+of+Adolescents+with+Perinatally+or+Transfusion+Acquired+HIV+Infection%3A+Sexual+Knowledge%2C+Risk+Reduction+Self-efficacy+and+Sexual+Behavior&rft.au=Wiener%2C+Lori+S%3BBattles%2C+Haven+B%3BWood%2C+Lauren+V&rft.aulast=Wiener&rft.aufirst=Lori&rft.date=2007-05-01&rft.volume=11&rft.issue=3&rft.spage=471&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-006-9162-y LA - English DB - Social Services Abstracts N1 - Date revised - 2008-02-04 N1 - Last updated - 2016-09-28 N1 - CODEN - AIBEFC N1 - SubjectsTermNotLitGenreText - Acquired Immune Deficiency Syndrome; Empowerment; Risk; Sex Information; Sexual Behavior; Condoms; Adolescents; Child Sexual Abuse DO - http://dx.doi.org/10.1007/s10461-006-9162-y ER - TY - JOUR T1 - The socio-economic determinants of older people's health in Brazil: the importance of marital status and income AN - 36774441; 3479391 AB - Studies in various countries have reported that older people who are married have better health than older widows. This paper reports a replication of these analyses with Brazilian data. The main objective was to explore the relationships between marital status, individual and household income, and the health of men and women using ordered logistic regression with self-assessed health as the dependent variable. The explanatory variables of interest were gender, marital status, and individual and family income. The data are from a survey of 7,920 non-institutionalised older people residnet in the southern state of Rio Grande do Sul in 1995. The survey used a structured, multi-disciplinary questionnaire, which collected information on demographic attributes, household composition, social relations, occupation, income and health status. The results show that widows were 20 per cent more likely to report better health than married women. The women without individual income had worse health than those who did, even after controlling for family income. For men, there were no significant differences in health by marital status. The main recommendation is that the health status and economic circumstances of married elderly women should be given more attention in both research and policy, certainly in Brazil and probably in other Latin American countries. Programmes of income support to the poorest households should include specific to these elderly women. Brazil's Family Health and Older People's Health public programmes should place more emphasis on the health of elderly home-makers. Reprinted by permission of Cambridge University Press. An electronic version of this article can be accessed via the internet at http://journals.cambridge.org JF - Ageing and society AU - Bós, Antônio M AU - Bós, Ângelo J AD - Tusculum College ; National Institute on Aging, Baltimore Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 385 EP - 406 VL - 27 IS - 3 SN - 0144-686X, 0144-686X KW - Anthropology KW - Demography KW - Ageing KW - Population ageing KW - Social relations KW - Socioeconomic status KW - Marital status KW - Brazil KW - Aged KW - Population KW - Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36774441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ageing+and+society&rft.atitle=The+socio-economic+determinants+of+older+people%27s+health+in+Brazil%3A+the+importance+of+marital+status+and+income&rft.au=B%C3%B3s%2C+Ant%C3%B4nio+M%3BB%C3%B3s%2C+%C3%82ngelo+J&rft.aulast=B%C3%B3s&rft.aufirst=Ant%C3%B4nio&rft.date=2007-05-01&rft.volume=27&rft.issue=3&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=Ageing+and+society&rft.issn=0144686X&rft_id=info:doi/10.1017%2FS0144686X06005472 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 655; 9846; 11988 4011 3974 9390 11932 2328 11935 5837 2360 2688 2449 10404 11936; 9848 655; 654; 11907; 5772; 7699 7748 6823; 3412; 63 386 14 DO - http://dx.doi.org/10.1017/S0144686X06005472 ER - TY - JOUR T1 - Early predictors of self-biting in socially-housed rhesus macaques (Macaca mulatta) AN - 36742425; 3463683 AB - The development of self-biting behavior in captive monkeys is little understood and poses a serious risk to their well-being. Although early rearing conditions may influence the expression of this behavior, not all animals reared under similar conditions self-bite. The purpose of this study was to examine the effects of three rearing conditions on biting behavior and to determine whether early infant behavior can predict later self-biting. The subjects were 370 rhesus macaques born at the National Institutes of Health (NIH) Animal Center between 1994 and 2004. They were reared under three conditions: mother-reared in social groups (n = 183), peer-reares in groups of four (n = 84), and surrogate-peer-reared (n = 103). Significantly more surrogate-peer-reared animals self-bit compared to peer-only or mother-reared animals. There was no sex difference in self-biting, but this result may have been affected by a sex bias in the number of observations. The durations of behaviors exhibited by the surrogate-peer-reared subjects were recorded in 5-min sessions twice a week from 2 to 6 months of age while the animals were in their home cages and play groups. In the play-group situation, surrogate-peer-reared subjects who later self-bit were found to be less social and exhibited less social clinging than those that did not self-bite. Home-cage behavior did not predict later self-biting, but it did change with increasing age: surrogate clinging and self-mouthing decreased, while environmental exploration increased. Our findings suggest that surrogate rearing in combination with lower levels of social contact during play may be risk factors for the later development of self-biting behavior. Copyright John Wiley & Sons. Reproduced with permission. An electronic version of this article is available online at http://www.interscience.wiley.com JF - American journal of primatology AU - Lutz, Corrine K AU - Davis, Ernie B AU - Ruggiero, Angela M AU - Suomi, Stephen J AD - NIH Animal Center ; National Institute of Child Health and Human Development Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 584 EP - 590 VL - 69 IS - 5 SN - 0275-2565, 0275-2565 KW - Anthropology KW - Macaques KW - Biological anthropology KW - Physical anthropology KW - Primatology KW - Social behaviour KW - Primate behaviour KW - Primates KW - Methodology KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36742425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+primatology&rft.atitle=Early+predictors+of+self-biting+in+socially-housed+rhesus+macaques+%28Macaca+mulatta%29&rft.au=Lutz%2C+Corrine+K%3BDavis%2C+Ernie+B%3BRuggiero%2C+Angela+M%3BSuomi%2C+Stephen+J&rft.aulast=Lutz&rft.aufirst=Corrine&rft.date=2007-05-01&rft.volume=69&rft.issue=5&rft.spage=584&rft.isbn=&rft.btitle=&rft.title=American+journal+of+primatology&rft.issn=02752565&rft_id=info:doi/10.1002%2Fajp.20370 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1608 1077; 10148; 10144 10148 10149 1542 11325; 11776; 6495 2212; 7994; 9507 1077; 10149 DO - http://dx.doi.org/10.1002/ajp.20370 ER - TY - JOUR T1 - Estimating age-specific breast cancer risks: a descriptive tool to identify age interactions AN - 20729688; 7373435 AB - Objective: Clarifying age-specific female breast cancer risks and interactions may provide important etiologic clues. Method: Using a population-based case-control study in Poland (2000-2003) of 2,386 incident breast cancer cases and 2,502 control subjects aged 25-74 years, we estimated age-specific breast cancer incidence rates according to risk factors. Results: Breast cancer risks were elevated among women with positive family history (FH), younger age at menarche, older age at first full-term birth, nulliparity, exogenous hormonal usage, and reduced physical activity (PA). Notwithstanding overall risks, we observed statistically significant quantitative (non-crossover) and qualitative (crossover) age interactions for all risk factors except for FH and PA. For example, nulliparity compared to parity reduced breast cancer risk among women ages 25-39 years then rates crossed or reversed, after which nulliparity increased relative risks among women ages 40-74 years. Conclusion: Though quantitative age interactions could be expected, qualitative interactions were somewhat counterintuitive. If confirmed in other populations, qualitative interactions for a continuous covariate such as age will be difficult to reconcile in a sequential (multistep or monolithic) 'stochastic' breast cancer model. Alternatively, the reversal of relative risks among younger and older women suggests subgroup heterogeneity with different etiologic mechanisms for early-onset and late-onset breast cancer types. JF - Cancer Causes & Control AU - Anderson, William F AU - Matsuno, Rayna K AU - Sherman, Mark E AU - Lissowska, Jolanta AU - Gail, Mitchell H AU - Brinton, Louise A AU - Yang, Xiaohong AU - Peplonska, Beata AU - Chen, Bingshu E AU - Rosenberg, Philip S AU - Chatterjee, Nilanjan AU - Szeszenia-D[aogon ]browska, Neonila AU - Bardin-Mikolajczak, Alicja AU - Zatonski, Witold AU - Devesa, Susan S AU - Garcia-Closas, Montserrat AD - DHHS/NIH/NCI/DCEG, EPS, Room 8036, 6120 Executive Blvd, Bethesda, MD, 20892-7244, USA, wanderso@mail.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 439 EP - 447 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 18 IS - 4 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - Genetics KW - Age KW - parity KW - Poland KW - Breast cancer KW - physical activity KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20729688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Estimating+age-specific+breast+cancer+risks%3A+a+descriptive+tool+to+identify+age+interactions&rft.au=Anderson%2C+William+F%3BMatsuno%2C+Rayna+K%3BSherman%2C+Mark+E%3BLissowska%2C+Jolanta%3BGail%2C+Mitchell+H%3BBrinton%2C+Louise+A%3BYang%2C+Xiaohong%3BPeplonska%2C+Beata%3BChen%2C+Bingshu+E%3BRosenberg%2C+Philip+S%3BChatterjee%2C+Nilanjan%3BSzeszenia-D%5Baogon+%5Dbrowska%2C+Neonila%3BBardin-Mikolajczak%2C+Alicja%3BZatonski%2C+Witold%3BDevesa%2C+Susan+S%3BGarcia-Closas%2C+Montserrat&rft.aulast=Anderson&rft.aufirst=William&rft.date=2007-05-01&rft.volume=18&rft.issue=4&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-006-0092-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genetics; parity; Age; Breast cancer; physical activity; Cancer; Poland DO - http://dx.doi.org/10.1007/s10552-006-0092-9 ER - TY - JOUR T1 - Use of Antibody as Carrier of Oligomers of Peptidomimetic alpha sub(v) beta sub(3) Antagonist to Target Tumor-Induced Neovasculature AN - 20418130; 7650936 AB - Sulfhydryl selective reactions were explored to conjugate oligomers of a peptidomimetic integrin alpha sub(v) beta sub(3) antagonist, 4-[2-(3,4,5,6-tetrahydropyrimidine-2-ylamino) ethyloxy]benzoyl-2-(S)-aminoethysulfonylamino- beta -alanine (IA) to monoclonal antibody (MoAb) to increase integrin alpha sub(v) beta sub(3) receptor-binding avidity. To generate sulfhydryl groups, N-succinimidyl-S-acetylthioacetate (SATA) was conjugated to both MoAb and IA. Sulfhydryl groups were then generated upon the deacetylation of the protecting acetyl group from the S-acetylthioacetato (ATA) moiety of MoAb-(ATA) sub(n) or IA-ATA with 0.02 M hydroxylamine in the presence of 1 mM EDTA at pH 7.2. The major focus was on optimizing the reaction concentrations, molar ratios, and reaction pH to conjugate high levels of IA-(A-SH) to MoAb-(A-SH) sub(n) without causing the inter- and intramolecular cross-linking of MoAb. Stepwise reactions of MoAb-(A-SH) sub(n) (15 mu M MoAb) with a homobifunctional cross-linker, 1,8-bis(maleimido)diethylene glycol (BM[PEO] sub(2)) at a >50x molar excess to the -SH, followed by the reaction of the purified product MoAb-(A-S-succinimidomaleimido-[PEO] sub(2)) sub(n) with IA-(A-SH) at pH 7.2 afforded monomeric MoAb-(A-S-succinimido-[PEO] sub(2)-succinimido-S-A-IA) sub(n) with 70% bindability to 0.4 mu M alpha sub(v)3 sub(3). When injected iv to nude mice with the receptor-positive M21 tumor, MoAb-IA sub(10) radiolabeled with both super(111)In and super(125)I accumulated rapidly and was retained in the tumor for a 44 h period while the radioactivity cleared rapidly from the blood, thereby resulting in increasing tumor-to-blood ratios over time. The tumor uptake was similar between the super(125)I label and the super(111)In label for a 44 h period. In contrast, the blood radioactivity was lower, but liver and other organ uptakes were much higher for the super(111)In label than for the super(125)I. The super(111)In label produced higher tumor-to-blood ratios but much lower tumor-to-organ ratios than the super(125)I. The rapid blood clearance, a short peak tumor uptake time, and a low peak tumor uptake value with prolonged tumor retention of this macromolecule appear to support a hypothesis that MoAb-IA sub(10) primarily binds to alpha sub(v) beta sub(3) receptors on angiogenic vessels, but not on the tumor. This hypothesis was substantiated by the fluorescence microscopic analysis of FITC-MoAb-IA sub(10), which showed that FITC-MoAb-IA sub(10) outlined neovasculatures but not tumor cells at 4 and 21 h ex vivo. Additional proof was observed when blood vessels outlined with rhodamine-lectin, which specifically binds to blood vessels, were superimposable on neovasculatures outlined with FITC-MoAb-IA sub(10). JF - Bioconjugate Chemistry AU - Shin, I S AU - Jang, B-S AU - Danthi, S N AU - Xie, J AU - Yu, S AU - Le, N AU - Maeng, J-S AU - Hwang, I S AU - Li, KCP AU - Carrasquillo, JA AU - Paik, CH AD - Department of Nuclear Medicine and Department of Radiology, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 821 EP - 828 VL - 18 IS - 3 SN - 1043-1802, 1043-1802 KW - Biotechnology Research Abstracts (through 1992) KW - Hydroxylamine KW - Macromolecules KW - Fluorescence KW - Monoclonal antibodies KW - peptidomimetics KW - Angiogenesis KW - Deacetylation KW - Sulfhydryl groups KW - Tumors KW - Tumor cells KW - Blood vessels KW - Avidity KW - Integrins KW - Liver KW - Radioactivity KW - pH effects KW - Edetic acid KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20418130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioconjugate+Chemistry&rft.atitle=Use+of+Antibody+as+Carrier+of+Oligomers+of+Peptidomimetic+alpha+sub%28v%29+beta+sub%283%29+Antagonist+to+Target+Tumor-Induced+Neovasculature&rft.au=Shin%2C+I+S%3BJang%2C+B-S%3BDanthi%2C+S+N%3BXie%2C+J%3BYu%2C+S%3BLe%2C+N%3BMaeng%2C+J-S%3BHwang%2C+I+S%3BLi%2C+KCP%3BCarrasquillo%2C+JA%3BPaik%2C+CH&rft.aulast=Shin&rft.aufirst=I&rft.date=2007-05-01&rft.volume=18&rft.issue=3&rft.spage=821&rft.isbn=&rft.btitle=&rft.title=Bioconjugate+Chemistry&rft.issn=10431802&rft_id=info:doi/10.1021%2Fbc0603485 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Tumors; pH effects; Blood vessels; Radioactivity; Sulfhydryl groups; Integrins; peptidomimetics; Angiogenesis; Hydroxylamine; Deacetylation; Avidity; Fluorescence; Liver; Monoclonal antibodies; Edetic acid; Tumor cells; Macromolecules DO - http://dx.doi.org/10.1021/bc0603485 ER - TY - JOUR T1 - Direct Identification of Nonreducing GlcNAc Residues on N-Glycans of Glycoproteins Using a Novel Chemoenzymatic Method AN - 20344264; 7650934 AB - The mutant beta 1,4-galactosyltransferase ( beta 4Gal-T1), beta 4Gal-T1-Y289L, in contrast to wild-type beta 4Gal-T1, can transfer GalNAc from the sugar donor UDP-GalNAc to the acceptor, GlcNAc, with efficiency as good as that of galactose from UDP-Gal. Furthermore, the mutant can also transfer a modified sugar, C2 keto galactose, from its UDP derivative to O-GlcNAc modification on proteins that provided a functional handle for developing a highly sensitive chemoenzymatic method for detecting O-GlcNAc post-translational modification on proteins. We report herein that the modified sugar, C2 keto galactose, can be transferred to free GlcNAc residues on N-linked glycoproteins, such as ovalbumin or asialo-agalacto IgG1. The transfer is strictly dependent on the presence of both the mutant enzyme and the ketone derivative of the galactose. Moreover, the PNGase F treatment of the glycoproteins, which cleaves the N-linked oligosaccharide chain, shows that the modified sugar has been transferred to the N-glycan chains of the glycoproteins and not to the protein portion. The application of the mutant galactosyltransferase, beta 4Gal-T1-Y289L, to produce glycoconjugates carrying sugar moieties with reactive groups, is demonstrated. We envision a broad potential for this technology such as the possibilities to link cargo molecules to glycoproteins, such as monoclonal antibodies, via glycan chains, thereby assisting in the glycotargeting of drugs to the site of action or used as biological probes. JF - Bioconjugate Chemistry AU - Boeggeman, E AU - Ramakrishnan, B AU - Kilgore, C AU - Khidekel, N AU - Hsieh-Wilson, L C AU - Simpson, J T AU - Qasba, P K AD - Structural Glycobiology Section, CCR-Nanobiology Program, Center for Cancer Research, NCI-Frederick, and Protein Chemistry Laboratory, SAIC-Inc. NCI-Frederick, Frederick, Maryland 21702, USA Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 806 EP - 814 VL - 18 IS - 3 SN - 1043-1802, 1043-1802 KW - Biotechnology and Bioengineering Abstracts KW - Galactose KW - Ovalbumin KW - Sugar KW - oligosaccharides KW - Monoclonal antibodies KW - Enzymes KW - Polysaccharides KW - glycoconjugates KW - Post-translation KW - N-Acetyllactosamine synthase KW - N-glycans KW - Immunoglobulin G KW - Glycoproteins KW - ketones KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20344264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioconjugate+Chemistry&rft.atitle=Direct+Identification+of+Nonreducing+GlcNAc+Residues+on+N-Glycans+of+Glycoproteins+Using+a+Novel+Chemoenzymatic+Method&rft.au=Boeggeman%2C+E%3BRamakrishnan%2C+B%3BKilgore%2C+C%3BKhidekel%2C+N%3BHsieh-Wilson%2C+L+C%3BSimpson%2C+J+T%3BQasba%2C+P+K&rft.aulast=Boeggeman&rft.aufirst=E&rft.date=2007-05-01&rft.volume=18&rft.issue=3&rft.spage=806&rft.isbn=&rft.btitle=&rft.title=Bioconjugate+Chemistry&rft.issn=10431802&rft_id=info:doi/10.1021%2Fbc060341n LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Glycoproteins; Sugar; Galactose; N-glycans; Post-translation; Monoclonal antibodies; Enzymes; Polysaccharides; ketones; N-Acetyllactosamine synthase; Immunoglobulin G; glycoconjugates; oligosaccharides; Ovalbumin DO - http://dx.doi.org/10.1021/bc060341n ER - TY - JOUR T1 - GAPWM: a genetic algorithm method for optimizing a position weight matrix AN - 20224137; 7415320 AB - MOTIVATION: Position weight matrices (PMWs) are simple models commonly used in motif-finding algorithms to identify short functional elements, such as cis-regulatory motifs, on genes. When few experimentally verified motifs are available, estimation of the PWM may be poor. The resultant PWM may not reliably discriminate a true motif from a false one. While experimentally identifying such motifs remains time-consuming and expensive, low-resolution binding data from techniques such as ChIP-on-chip and ChIP-PET have become available. We propose a novel but simple method to improve a poorly estimated PWM using ChIP data. METHODOLOGY: Starting from an existing PWM, a set of ChIP sequences, and a set of background sequences, our method, GAPWM, derives an improved PWM via a genetic algorithm that maximizes the area under the receiver operating characteristic (ROC) curve. GAPWM can easily incorporate prior information such as base conservation. We tested our method on two PMWs (Oct4/Sox2 and p53) using three recently published ChIP data sets (human Oct4, mouse Oct4 and human p53). RESULTS: GAPWM substantially increased the sensitivity/specificity of a poorly estimated PWM and further improved the quality of a good PWM. Furthermore, it still functioned when the starting PWM contained a major error. The ROC performance of GAPWM compared favorably with that of MEME and others. With increasing availability of ChIP data, our method provides an alternative for obtaining high-quality PWMs for genome-wide identification of transcription factor binding sites. AVAILABILITY: The C source code and all data used in this report are available at http://dir.niehs.nih.gov/dirbb/gapwm CONTACT: li3atniehs.nih.gov Supplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Li, Leping AU - Liang, Yu AU - Bass, Robert L AD - Biostatistics Branch and Computational Biology Facility, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 1188 EP - 1194 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 23 IS - 10 SN - 1367-4803, 1367-4803 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Data processing KW - Transcription factors KW - Algorithms KW - Bioinformatics KW - Oct-4 protein KW - p53 protein KW - G 07750:Ecological & Population Genetics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20224137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=GAPWM%3A+a+genetic+algorithm+method+for+optimizing+a+position+weight+matrix&rft.au=Li%2C+Leping%3BLiang%2C+Yu%3BBass%2C+Robert+L&rft.aulast=Li&rft.aufirst=Leping&rft.date=2007-05-01&rft.volume=23&rft.issue=10&rft.spage=1188&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Data processing; Transcription factors; Algorithms; Bioinformatics; Oct-4 protein; p53 protein ER - TY - JOUR T1 - Simultaneous two-color spectral fluorescence lymphangiography with near infrared quantum dots to map two lymphatic flows from the breast and the upper extremity AN - 19985305; 7387258 AB - Due to their small size and poor access, the lymphatic function has been difficult to study in vivo. Especially difficult is the mapping of lymphatic drainage from two basins into the same node. Quantum dots can be used to perform multicolor images with high fluorescent intensity and are of a nano-size size suitable for lymphatic imaging via direct interstitial injection. Here we show simultaneous two-color in vivo wavelength-resolved spectral fluorescence lymphangiography using two near infrared quantum dots with different emission spectra, which allow non-invasive and simultaneous visualization of two separate lymphatic flows draining the breast and the upper extremity and variations in the drainage patterns and the water sheds within the axillary node. Two-color spectral fluorescence lymphangiography can provide insight into mechanisms of drainage from different lymphatic basins that may lead to sentinel lymph nodes detection of the breast cancer as well as prevention of complications such as lymphedema of the arm. JF - Breast Cancer Research and Treatment AU - Hama, Yukihiro AU - Koyama, Yoshinori AU - Urano, Yasuteru AU - Choyke, Peter L AU - Kobayashi, Hisataka AD - National Cancer Institute, NIH, Bldg. 10, Room 1B40, MSC 1088, Bethesda, MD, 20892-1088, USA, Kobayash@mail.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 23 EP - 28 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 103 IS - 1 SN - 0167-6806, 0167-6806 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Fluorescence KW - Drainage KW - Basins KW - imaging KW - Lymph nodes KW - Lymphangiography KW - Quantum dots KW - Breast cancer KW - Mapping KW - W 30910:Imaging KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19985305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Breast+Cancer+Research+and+Treatment&rft.atitle=Simultaneous+two-color+spectral+fluorescence+lymphangiography+with+near+infrared+quantum+dots+to+map+two+lymphatic+flows+from+the+breast+and+the+upper+extremity&rft.au=Hama%2C+Yukihiro%3BKoyama%2C+Yoshinori%3BUrano%2C+Yasuteru%3BChoyke%2C+Peter+L%3BKobayashi%2C+Hisataka&rft.aulast=Hama&rft.aufirst=Yukihiro&rft.date=2007-05-01&rft.volume=103&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Breast+Cancer+Research+and+Treatment&rft.issn=01676806&rft_id=info:doi/10.1007%2Fs10549-006-9347-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Drainage; Quantum dots; Fluorescence; Lymphangiography; Basins; Breast cancer; imaging; Mapping; Lymph nodes DO - http://dx.doi.org/10.1007/s10549-006-9347-0 ER - TY - JOUR T1 - CD34 Expression by Hair Follicle Stem Cells Is Required for Skin Tumor Development in Mice AN - 19964633; 7416884 AB - The cell surface marker CD34 marks mouse hair follicle bulge cells, which have attributes of stem cells, including quiescence and multipotency. Using a CD34 knockout (KO) mouse, we tested the hypothesis that CD34 may participate in tumor development in mice because hair follicle stem cells are thought to be a major target of carcinogens in the two-stage model of mouse skin carcinogenesis. Following initiation with 200 nmol 7,12-dimethylbenz(a)anthracene (DMBA), mice were promoted with 12-O-tetradecanoylphorbol-13-acetate (TPA) for 20 weeks. Under these conditions, CD34KO mice failed to develop papillomas. Increasing the initiating dose of DMBA to 400 nmol resulted in tumor development in the CD34KO mice, albeit with an increased latency and lower tumor yield compared with the wild-type (WT) strain. DNA adduct analysis of keratinocytes from DMBA-initiated CD34KO mice revealed that DMBA was metabolically activated into carcinogenic diol epoxides at both 200 and 400 nmol. Chronic exposure to TPA revealed that CD34KO skin developed and sustained epidermal hyperplasia. However, CD34KO hair follicles typically remained in telogen rather than transitioning into anagen growth, confirmed by retention of bromodeoxyuridine-labeled bulge stem cells within the hair follicle. Unique localization of the hair follicle progenitor cell marker MTS24 was found in interfollicular basal cells in TPA-treated WT mice, whereas staining remained restricted to the hair follicles of CD34KO mice, suggesting that progenitor cells migrate into epidermis differently between strains. These data show that CD34 is required for TPA-induced hair follicle stem cell activation and tumor formation in mice. [Cancer Res 2007; 67(9):4173-81] JF - Cancer Research AU - Trempus, Carol S AU - Morris, Rebecca J AU - Ehinger, Matthew AU - Elmore, Amy AU - Bortner, Carl D AU - Ito, Mayumi AU - Cotsarelis, George AU - Nijhof, Joanne GW AU - Peckham, John AU - Flagler, Norris AU - Kissling, Grace AU - Humble, Margaret M AU - King, Leon C AU - Adams, Linda D AU - Desai, Dhimant AU - Amin, Shantu AU - Tennant, Raymond W AD - Cancer Biology Group, Laboratory of Molecular Toxicology, Laboratory of Signal Transduction, Laboratory of Experimental Pathology, and Biostatistics Branch, National Institute of Environmental Health Sciences Y1 - 2007/05/01/ PY - 2007 DA - 2007 May 01 SP - 4173 EP - 4181 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 67 IS - 9 SN - 0008-5472, 0008-5472 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Cell surface KW - Epoxides KW - Animal models KW - Carcinogens KW - 12-O-Tetradecanoylphorbol-13-acetate KW - TPA KW - Cell activation KW - Stem cells KW - Chronic exposure KW - Keratinocytes KW - Cell migration KW - Papilloma KW - DNA adducts KW - Data processing KW - Skin KW - Follicles KW - CD34 antigen KW - Tumors KW - Hair KW - Cancer KW - Epidermis KW - Basal cells KW - Hyperplasia KW - 9,10-Dimethyl-1,2-benzanthracene KW - Carcinogenesis KW - W 30940:Products KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19964633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=CD34+Expression+by+Hair+Follicle+Stem+Cells+Is+Required+for+Skin+Tumor+Development+in+Mice&rft.au=Trempus%2C+Carol+S%3BMorris%2C+Rebecca+J%3BEhinger%2C+Matthew%3BElmore%2C+Amy%3BBortner%2C+Carl+D%3BIto%2C+Mayumi%3BCotsarelis%2C+George%3BNijhof%2C+Joanne+GW%3BPeckham%2C+John%3BFlagler%2C+Norris%3BKissling%2C+Grace%3BHumble%2C+Margaret+M%3BKing%2C+Leon+C%3BAdams%2C+Linda+D%3BDesai%2C+Dhimant%3BAmin%2C+Shantu%3BTennant%2C+Raymond+W&rft.aulast=Trempus&rft.aufirst=Carol&rft.date=2007-05-01&rft.volume=67&rft.issue=9&rft.spage=4173&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell surface; Epoxides; Animal models; Carcinogens; TPA; 12-O-Tetradecanoylphorbol-13-acetate; Cell activation; Stem cells; Chronic exposure; Cell migration; Keratinocytes; Papilloma; DNA adducts; Skin; Data processing; Follicles; CD34 antigen; Tumors; Hair; Cancer; Epidermis; Hyperplasia; Basal cells; 9,10-Dimethyl-1,2-benzanthracene; Carcinogenesis ER - TY - JOUR T1 - Compartmental Pharmacokinetic Analysis of Oral Amprenavir with Secondary Peaks AN - 19940571; 7403192 AB - Amprenavir is a protease inhibitor that has been shown to have secondary peaks postulated to be due to enterohepatic recycling. We propose a model to describe the pharmacokinetics of amprenavir which accommodates the secondary peak(s). A total of 82 healthy human immunodeficiency virus (HIV)-seronegative subjects were administered a single 600-mg dose of amprenavir as part of adult AIDS Clinical Trials Group protocol A5043. Serial blood samples were obtained over 24 h. Samples were analyzed for amprenavir and fit to a compartmental model using ADAPT II software, with all relevant parameters conditional with respect to bioavailability. The model accommodated secondary peaks by incorporating clearance out of the central compartment with delayed instantaneous release back into the gut compartment. The data were weighted by the inverse of the estimated measurement error variance; model discrimination was determined using Akaike's Information Criteria. A total of 76 subjects were evaluable in the study analysis. The data were best fit by a two-compartment model, with 98.7% of the subjects demonstrating a secondary peak. Amprenavir had a mean total clearance of 1.163 liters/h/kg of body weight (0.7), a central volume of distribution of 1.208 liters/kg (0.8), a peripheral volume of distribution of 8.2 liters/kg (0.81), and distributional clearance of 0.04 liters/h/kg (0.81). The time to the secondary peak was 7.86 h (0.17), and clearance into a recycling compartment was 0.111 liters/kg/h (0.74). Amprenavir pharmacokinetics has been well described using a two-compartment model with clearance to a recycling compartment and release back into the gut. The nature of the secondary peaks may be an important consideration for the interpretation of amprenavir plasma concentrations during therapeutic drug monitoring. JF - Antimicrobial Agents & Chemotherapy AU - Okusanya, Olanrewaju AU - Forrest, Alan AU - DiFrancesco, Robin AU - Bilic, Sanela AU - Rosenkranz, Susan AU - Para, Michael F AU - Adams, Elizabeth AU - Yarasheski, Kevin E AU - Reichman, Richard C AU - Morse, Gene D AD - University at Buffalo School of Pharmacy, SUNY, Buffalo, New York. Harvard University, Boston, Massachusetts. Ohio State University, Columbus, Ohio. NIAID, Division of AIDS, Bethesda, Maryland. Washington University, St. Louis, Missouri. University of Rochester, Rochester, New York Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 1822 EP - 1826 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 51 IS - 5 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Acquired immune deficiency syndrome KW - Data processing KW - Proteinase inhibitors KW - Recycling KW - Clinical trials KW - Pharmacokinetics KW - Antimicrobial agents KW - Models KW - Bioavailability KW - Computer programs KW - software KW - Digestive tract KW - Body weight KW - Human immunodeficiency virus KW - Drugs KW - amprenavir KW - A 01340:Antibiotics & Antimicrobials KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19940571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Compartmental+Pharmacokinetic+Analysis+of+Oral+Amprenavir+with+Secondary+Peaks&rft.au=Okusanya%2C+Olanrewaju%3BForrest%2C+Alan%3BDiFrancesco%2C+Robin%3BBilic%2C+Sanela%3BRosenkranz%2C+Susan%3BPara%2C+Michael+F%3BAdams%2C+Elizabeth%3BYarasheski%2C+Kevin+E%3BReichman%2C+Richard+C%3BMorse%2C+Gene+D&rft.aulast=Okusanya&rft.aufirst=Olanrewaju&rft.date=2007-05-01&rft.volume=51&rft.issue=5&rft.spage=1822&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; Data processing; Proteinase inhibitors; Recycling; Clinical trials; Pharmacokinetics; Models; Antimicrobial agents; Computer programs; Bioavailability; software; Digestive tract; Body weight; Drugs; amprenavir; Human immunodeficiency virus ER - TY - JOUR T1 - The synthesis and initial characterization of an immobilized purinergic receptor (P2Y1) liquid chromatography stationary phase for online screening AN - 19728530; 7536956 JF - Analytical Biochemistry AU - Moaddel, Ruin AU - Calleri, Enrica AU - Massolini, Gabriella AU - Frazier, Chester R AU - Wainer, Irving W AD - Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA, moaddelru@grc.nia.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 216 EP - 218 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 364 IS - 2 SN - 0003-2697, 0003-2697 KW - Biotechnology and Bioengineering Abstracts KW - stationary phase KW - Purine receptors KW - Liquid chromatography KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19728530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Biochemistry&rft.atitle=The+synthesis+and+initial+characterization+of+an+immobilized+purinergic+receptor+%28P2Y1%29+liquid+chromatography+stationary+phase+for+online+screening&rft.au=Moaddel%2C+Ruin%3BCalleri%2C+Enrica%3BMassolini%2C+Gabriella%3BFrazier%2C+Chester+R%3BWainer%2C+Irving+W&rft.aulast=Moaddel&rft.aufirst=Ruin&rft.date=2007-05-01&rft.volume=364&rft.issue=2&rft.spage=216&rft.isbn=&rft.btitle=&rft.title=Analytical+Biochemistry&rft.issn=00032697&rft_id=info:doi/10.1016%2Fj.ab.2007.02.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Purine receptors; Liquid chromatography; stationary phase DO - http://dx.doi.org/10.1016/j.ab.2007.02.014 ER - TY - JOUR T1 - COBALT: constraint-based alignment tool for multiple protein sequences AN - 19670057; 7415366 AB - MOTIVATION: A tool that simultaneously aligns multiple protein sequences, automatically utilizes information about protein domains, and has a good compromise between speed and accuracy will have practical advantages over current tools. RESULTS: We describe COBALT, a constraint based alignment tool that implements a general framework for multiple alignment of protein sequences. COBALT finds a collection of pairwise constraints derived from database searches, sequence similarity and user input, combines these pairwise constraints, and then incorporates them into a progressive multiple alignment. We show that using constraints derived from the conserved domain database (CDD) and PROSITE protein-motif database improves COBALT's alignment quality. We also show that COBALT has reasonable runtime performance and alignment accuracy comparable to or exceeding that of other tools for a broad range of problems. AVAILABILITY: COBALT is included in the NCBI C++ toolkit. A Linux executable for COBALT, and CDD and PROSITE data used is available at: ftp://ftp.ncbi.nlm.nih.gov/pub/agarwala/cobalt CONTACT: richa@helix.nih.gov JF - Bioinformatics AU - Papadopoulos, Jason S AU - Agarwala, Richa AD - National Center for Biotechnology Information, National Institutes of Health, Department of Health and Human Services, Bldg. 38A, Room 10-03N, 8600 Rockville Pike, Bethesda, MD 20894, USA Y1 - 2007/05/01/ PY - 2007 DA - 2007 May 01 SP - 1073 EP - 1079 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 23 IS - 9 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Cobalt KW - Bioinformatics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19670057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=COBALT%3A+constraint-based+alignment+tool+for+multiple+protein+sequences&rft.au=Papadopoulos%2C+Jason+S%3BAgarwala%2C+Richa&rft.aulast=Papadopoulos&rft.aufirst=Jason&rft.date=2007-05-01&rft.volume=23&rft.issue=9&rft.spage=1073&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cobalt; Databases; Bioinformatics ER - TY - JOUR T1 - rh_tsp_map 3.0: end-to-end radiation hybrid mapping with improved speed and quality control AN - 19659880; 7415376 AB - SUMMARY: rh_tsp_map is a software package for computing radiation hybrid (RH) maps and for integrating physical and genetic maps. It solves the central mapping instances by reducing them to the traveling salesman problem (TSP) and using a modification of the CONCORDE package to solve the TSP instances. We present some of the features added between the initial rh_tsp_map version 1.0 and the current version 3.0, emphasizing the automation of many steps and addition of various checks designed to find problems with the input data. Iterations of improved input data followed by fast re-computation of the maps improves the quality of the final maps. AVAILABILITY: rh_tsp_map source code and documentation including a tutorial is available at ftp://ftp.ncbi.nih.gov/pub/agarwala/rhmapping/rh_tsp_map.tar.gz. CONCORDE modified for RH mapping is available in the directory http://www.isye.gatech.edu/~wcook/rh/. The QSopt library needed for CONCORDE is available at http://www2.isye.gatech.edu/~wcook/qsopt/downloads/downloads.htm CONTACT: richa@helix.nih.gov, FAX: 301-480-2288. (Please send email concurrently with any fax.) JF - Bioinformatics AU - Schaeffer, Alejandro A AU - Rice, Edward Stallknecht AU - Cook, William AU - Agarwala, Richa AD - National Center for Biotechnology Information, National Institutes of Health, Department of Health and Human Services, Bldg. 38A, Room 10-03N, 8600 Rockville Pike, Bethesda, MD 20894, Thomas Jefferson High School for Science and Technology, 6560 Braddock Road, Alexandria, VA 22312 and Industrial and Systems Engineering, Georgia Tech, 765 Ferst Drive, Atlanta, GA 30332, USA Y1 - 2007/05/01/ PY - 2007 DA - 2007 May 01 SP - 1156 EP - 1158 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 23 IS - 9 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - software KW - Quality control KW - Automation KW - Bioinformatics KW - Gene mapping KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19659880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=rh_tsp_map+3.0%3A+end-to-end+radiation+hybrid+mapping+with+improved+speed+and+quality+control&rft.au=Schaeffer%2C+Alejandro+A%3BRice%2C+Edward+Stallknecht%3BCook%2C+William%3BAgarwala%2C+Richa&rft.aulast=Schaeffer&rft.aufirst=Alejandro&rft.date=2007-05-01&rft.volume=23&rft.issue=9&rft.spage=1156&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Gene mapping; software; Automation; Computer programs; Quality control; Bioinformatics ER - TY - JOUR T1 - Consumption of Dairy Products and Risk of Parkinson's Disease AN - 19451611; 7403814 AB - The authors prospectively investigated the association between intake of dairy products and risk of Parkinson's disease among 57,689 men and 73,175 women from the American Cancer Society's Cancer Prevention Study II Nutrition Cohort. A total of 250 men and 138 women with Parkinson's disease were identified during follow-up (1992-2001). Dairy product consumption was positively associated with risk of Parkinson's disease: Compared with the lowest intake quintile, the corresponding relative risks for quintiles 2-5 were 1.4, 1.4, 1.4, and 1.6 (95 percent confidence interval (CI): 1.1, 2.2; p for trend = 0.05). A higher risk among dairy product consumers was found in both men and women, although the association in women appeared nonlinear. Meta-analysis of all prospective studies confirmed a moderately elevated risk of Parkinson's disease among persons with high dairy product consumption: For extreme intake categories, relative risks were 1.6 (95 percent CI: 1.3, 2.0) for both sexes, 1.8 for men (95 percent CI: 1.4, 2.4), and 1.3 for women (95 percent CI: 0.8, 2.1). These data suggest that dairy consumption may increase the risk of Parkinson's disease, particularly in men. More studies are needed to further examine these findings and to explore underlying mechanisms. JF - American Journal of Epidemiology AU - Chen, Honglei AU - O'Reilly, Eilis AU - McCullough, Marjorie L AU - Rodriguez, Carmen AU - Schwarzschild, Michael A AU - Calle, Eugenia E AU - Thun, Michael J AU - Ascherio, Alberto AD - Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC Y1 - 2007/05/01/ PY - 2007 DA - 2007 May 01 SP - 998 EP - 1006 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 165 IS - 9 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; CSA Neurosciences Abstracts KW - Diets KW - Risk assessment KW - Parkinson's disease KW - Dairy products KW - Nutrition KW - Cancer KW - Neurodegenerative diseases KW - Movement disorders KW - Reviews KW - prevention KW - R2 23060:Medical and environmental health KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19451611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Consumption+of+Dairy+Products+and+Risk+of+Parkinson%27s+Disease&rft.au=Chen%2C+Honglei%3BO%27Reilly%2C+Eilis%3BMcCullough%2C+Marjorie+L%3BRodriguez%2C+Carmen%3BSchwarzschild%2C+Michael+A%3BCalle%2C+Eugenia+E%3BThun%2C+Michael+J%3BAscherio%2C+Alberto&rft.aulast=Chen&rft.aufirst=Honglei&rft.date=2007-05-01&rft.volume=165&rft.issue=9&rft.spage=998&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; Neurodegenerative diseases; Movement disorders; Reviews; Parkinson's disease; Dairy products; Nutrition; Diets; prevention; Cancer ER - TY - JOUR T1 - A drug burden index to define the functional burden of medications in older people. AN - 70428480; 17452540 AB - Older people carry a high burden of illness for which medications are indicated, along with increased risk of adverse drug reactions. We developed an index to determine drug burden based on pharmacologic principles. We evaluated the relationship of this index to physical and cognitive performance apart from disease indication. Data from the Health, Aging, and Body Composition Study on 3075 well-functioning community-dwelling persons aged 70 to 79 years were analyzed by multiple linear regression to assess the cross-sectional association of drug burden index with a validated composite continuous measure for physical function, and with the Digit Symbol Substitution Test for cognitive performance. Use of anticholinergic and sedative medications was associated with poorer physical performance score (anticholinergic exposure, 2.08 vs 2.21, P<.001; sedative exposure, 2.09 vs 2.19, P<.001) and cognitive performance on the Digit Symbol Substitution Test (anticholinergic exposure, 34.5 vs 35.5, P = .045; sedative exposure, 34.0 vs 35.5, P = .01). Associations were strengthened when exposure was calculated by principles of dose response. An increase of 1 U in drug burden index was associated with a deficit of 0.15 point (P<.001) on the physical function scale and 1.5 points (P = .01) on the Digit Symbol Substitution Test. These values were more than 3 times those associated with a single comorbid illness. The drug burden index demonstrates that anticholinergic and sedative drug exposure is associated with poorer function in community-dwelling older people. This pharmacologic approach provides a useful evidence-based tool for assessing the functional effect of exposure to medications in this population. JF - Archives of internal medicine AU - Hilmer, Sarah N AU - Mager, Donald E AU - Simonsick, Eleanor M AU - Cao, Ying AU - Ling, Shari M AU - Windham, B Gwen AU - Harris, Tamara B AU - Hanlon, Joseph T AU - Rubin, Susan M AU - Shorr, Ronald I AU - Bauer, Douglas C AU - Abernethy, Darrell R AD - Laboratory of Clinical Investigation and Clinical Research Branch, Intramural Research Program, National Institute on Aging, Baltimore and Bethesda, MD, USA. Y1 - 2007/04/23/ PY - 2007 DA - 2007 Apr 23 SP - 781 EP - 787 VL - 167 IS - 8 SN - 0003-9926, 0003-9926 KW - Cholinergic Antagonists KW - 0 KW - Hypnotics and Sedatives KW - Abridged Index Medicus KW - Index Medicus KW - Cognition -- drug effects KW - Humans KW - Aged KW - Hypnotics and Sedatives -- adverse effects KW - Cholinergic Antagonists -- adverse effects KW - Female KW - Drug-Related Side Effects and Adverse Reactions KW - Body Burden UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70428480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+internal+medicine&rft.atitle=A+drug+burden+index+to+define+the+functional+burden+of+medications+in+older+people.&rft.au=Hilmer%2C+Sarah+N%3BMager%2C+Donald+E%3BSimonsick%2C+Eleanor+M%3BCao%2C+Ying%3BLing%2C+Shari+M%3BWindham%2C+B+Gwen%3BHarris%2C+Tamara+B%3BHanlon%2C+Joseph+T%3BRubin%2C+Susan+M%3BShorr%2C+Ronald+I%3BBauer%2C+Douglas+C%3BAbernethy%2C+Darrell+R&rft.aulast=Hilmer&rft.aufirst=Sarah&rft.date=2007-04-23&rft.volume=167&rft.issue=8&rft.spage=781&rft.isbn=&rft.btitle=&rft.title=Archives+of+internal+medicine&rft.issn=00039926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-17 N1 - Date created - 2007-04-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Arch Intern Med. 2007 Apr 23;167(8):753-4 [17452536] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ivermectin Interaction with transmembrane helices reveals widespread rearrangements during opening of P2X receptor channels. AN - 70398140; 17442247 AB - P2X receptors are trimeric cation channels that open in response to binding of extracellular ATP. Each subunit contains a large extracellular ligand binding domain and two flanking transmembrane (TM) helices that form the pore, but the extent of gating motions of the TM helices is unclear. We probed these motions using ivermectin (IVM), a macrocyclic lactone that stabilizes the open state of P2X(4) receptor channels. We find that IVM partitions into lipid membranes and that transfer of the TM regions of P2X(4) receptors is sufficient to convey sensitivity to the lactone, suggesting that IVM interacts most favorably with the open conformation of the two TM helices at the protein-lipid interface. Scanning mutagenesis of the two TMs identifies residues that change environment between closed and open states, and substitutions at a subset of these positions weaken IVM binding. The emerging patterns point to widespread rearrangements of the TM helices during opening of P2X receptor channels. JF - Neuron AU - Silberberg, Shai D AU - Li, Mufeng AU - Swartz, Kenton J AD - Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. silberbs@ninds.nih.gov Y1 - 2007/04/19/ PY - 2007 DA - 2007 Apr 19 SP - 263 EP - 274 VL - 54 IS - 2 SN - 0896-6273, 0896-6273 KW - Lactones KW - 0 KW - Membrane Proteins KW - Receptors, Purinergic P2 KW - Receptors, Purinergic P2X2 KW - Ivermectin KW - 70288-86-7 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Animals KW - Porosity KW - Amino Acid Sequence KW - Oocytes -- physiology KW - Electrophysiology KW - Ion Channel Gating -- drug effects KW - Mutagenesis KW - Rats KW - Lactones -- chemistry KW - DNA -- genetics KW - Molecular Sequence Data KW - Xenopus KW - Adenosine Triphosphate -- pharmacology KW - Protein Conformation KW - Receptors, Purinergic P2 -- drug effects KW - Ivermectin -- pharmacology KW - Membrane Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70398140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuron&rft.atitle=Ivermectin+Interaction+with+transmembrane+helices+reveals+widespread+rearrangements+during+opening+of+P2X+receptor+channels.&rft.au=Silberberg%2C+Shai+D%3BLi%2C+Mufeng%3BSwartz%2C+Kenton+J&rft.aulast=Silberberg&rft.aufirst=Shai&rft.date=2007-04-19&rft.volume=54&rft.issue=2&rft.spage=263&rft.isbn=&rft.btitle=&rft.title=Neuron&rft.issn=08966273&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-31 N1 - Date created - 2007-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Post Katrina Population Estimates for Cancer Surveillance T2 - 2007 Meeting of the Association of American Geographers AN - 39390208; 4605968 JF - 2007 Meeting of the Association of American Geographers AU - Stinchcomb, David AU - Miller, Barry AU - Chen, Vivien Y1 - 2007/04/17/ PY - 2007 DA - 2007 Apr 17 KW - Cancer KW - Population characteristics KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39390208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+biology+and+medicine+%28Maywood%2C+N.J.%29&rft.atitle=Nutritional+interactions%3A+credentialing+of+molecular+targets+for+cancer+prevention.&rft.au=Davis%2C+Cindy+D&rft.aulast=Davis&rft.aufirst=Cindy&rft.date=2007-02-01&rft.volume=232&rft.issue=2&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=Experimental+biology+and+medicine+%28Maywood%2C+N.J.%29&rft.issn=15353702&rft_id=info:doi/ L2 - http://communicate.aag.org/eseries/aag_org/program/index.cfm?mtgID=52 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Synthesis and Absolute Configuration of Cis- and Trans-Opened Cyclopenta[cd]pyrene 3,4-Oxide N super(2)-Deoxyguanosine Adducts: Conversion to Phosphoramidites for Oligonucleotide Synthesis AN - 20678985; 7487027 AB - Fluorinated alcohols such as trifluoroethanol (TFE) or hexafluoropropan-2-ol (HFP) catalyze addition of the N super(2)-amino group of O super(6)-allyl-3',5'-di-O-(tert-butyldimethylsilyl)-2'-deoxyguanos ine (3) to cyclopenta[cd]pyrene 3,4-oxide (CPPO). The reaction occurs via a carbocation intermediate at C-3 such that cis- and trans-opened dGuo adducts are formed in a combined yield of similar to 37% together with the 4-ketone and a cis-opened solvent adduct. Fluorinated alcohol-mediated regioselective substitution at C-3 of the CPP cis- (11) and trans-3,4-dihydrodiol diacetates (15) with the N super(2)-amino group of 3 proceeded smoothly to give the O super(6)-allyl di-(tert-butyldimethylsilyl) cis- and trans-opened dGuo-adduct acetates (8a,b and 9a,b) in 75-85% yields. The cis-opened adducts predominated (56-70%) from both 11 and 15. Interestingly, trans-3-acetoxy-4-bromo-3,4-dihydro-CPP and 3 in TFE or HFP gave a mixture of 8a,b and 9a,b in 75-85% yield with cis:trans adduct ratios similar to those observed for 11 and 15. This observation is consistent with initial formation of a cyclic acetoxonium intermediate followed by formation of the same carbocation as that derived from 11 or 15. Absolute configurations of 8a,b and 9a,b were assigned by using enantiomerically pure (+)-trans-[3S.4S]-dihydrodiol as the starting material, which afforded a single cis-[3R,4S]-dGuo adduct and a single trans-[3S,4S]-dGuo adduct. The optically active trans-3,4-dihydrodiols were obtained by HPLC separation of their bis-(-)-menthoxyacetates. Their absolute configuration was determined by several empirical methods in addition to application of the exciton chirality CD method to their bis-(p-N,N-dimethylamino)benzoates. Removal of all blocking groups from the protected cis- and trans-opened dGuo adducts (8a,b and 9a,b) in three steps (overall yields of >70%) gave the free dGuo adducts, which are useful markers for DNA-binding studies. Adducts 8a,b and 9a,b were also converted to the appropriately protected phosphoramidites in three steps (overall yields of 72-81%). JF - Chemical Research in Toxicology AU - Yagi, H AU - Frank, H AU - Seidel, A AU - Jerina, D M AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, The National Institutes of Health, DHHS, Bethesda, Maryland 20892, USA Y1 - 2007/04/16/ PY - 2007 DA - 2007 Apr 16 SP - 650 EP - 661 VL - 20 IS - 4 SN - 0893-228X, 0893-228X KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - High-performance liquid chromatography KW - Adducts KW - alcohols KW - Solvents KW - Absolute configuration KW - Chirality KW - N2-deoxyguanosine KW - Oligonucleotides KW - Acetic acid KW - trifluoroethanol KW - N 14810:Methods KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20678985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Research+in+Toxicology&rft.atitle=Synthesis+and+Absolute+Configuration+of+Cis-+and+Trans-Opened+Cyclopenta%5Bcd%5Dpyrene+3%2C4-Oxide+N+super%282%29-Deoxyguanosine+Adducts%3A+Conversion+to+Phosphoramidites+for+Oligonucleotide+Synthesis&rft.au=Yagi%2C+H%3BFrank%2C+H%3BSeidel%2C+A%3BJerina%2C+D+M&rft.aulast=Yagi&rft.aufirst=H&rft.date=2007-04-16&rft.volume=20&rft.issue=4&rft.spage=650&rft.isbn=&rft.btitle=&rft.title=Chemical+Research+in+Toxicology&rft.issn=0893228X&rft_id=info:doi/10.1021%2Ftx600286z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Adducts; Solvents; alcohols; N2-deoxyguanosine; Chirality; Absolute configuration; Acetic acid; Oligonucleotides; trifluoroethanol DO - http://dx.doi.org/10.1021/tx600286z ER - TY - JOUR T1 - Safety and immunogenicity of a Gag-Pol candidate HIV-1 DNA vaccine administered by a needle-free device in HIV-1-seronegative subjects. AN - 70360746; 17325604 AB - To evaluate the safety and immunogenicity of a candidate HIV DNA vaccine administered using a needle-free device. In this phase 1, dose escalation, double-blind, placebo-controlled clinical trial, 21 healthy adults were randomized to receive placebo or 0.5, 1.5, or 4 mg of a single plasmid expressing a Gag/Pol fusion protein. Each participant received repeat immunizations at days 28 and 56 after the first inoculation. Safety and immunogenicity data were collected. The vaccine was well tolerated, with most adverse events being mild injection site reactions, including pain, tenderness, and erythema. No dose-limiting toxicities occurred. HIV-specific antibody response was not detected in any vaccinee by enzyme-linked immunosorbent assay. HIV-specific T-cell responses to Gag or Pol as measured by enzyme-linked immunospot assay and intracellular cytokine staining were of low frequency and magnitude. This candidate HIV DNA vaccine was safe and well tolerated. No HIV-specific antibody responses were detected, and only low-magnitude HIV-specific T-cell responses were detected in 8 (53%) of 15 vaccinees. This initial product led to the development of a 4-plasmid multiclade HIV DNA Vaccine Research Center vaccine candidate in which envelope genes expressing Env from clades A, B, and C and a Nef gene from clade B have been added. JF - Journal of acquired immune deficiency syndromes (1999) AU - Tavel, Jorge A AU - Martin, Julie E AU - Kelly, Grace G AU - Enama, Mary E AU - Shen, Jean M AU - Gomez, Phillip L AU - Andrews, Charla A AU - Koup, Richard A AU - Bailer, Robert T AU - Stein, Judy A AU - Roederer, Mario AU - Nabel, Gary J AU - Graham, Barney S AD - Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/04/15/ PY - 2007 DA - 2007 Apr 15 SP - 601 EP - 605 VL - 44 IS - 5 SN - 1525-4135, 1525-4135 KW - AIDS Vaccines KW - 0 KW - HIV Antibodies KW - Vaccines, DNA KW - Index Medicus KW - AIDS/HIV KW - Vaccines, DNA -- immunology KW - Double-Blind Method KW - Vaccines, DNA -- administration & dosage KW - Humans KW - Safety KW - Genes, pol KW - Vaccines, DNA -- adverse effects KW - Immunity, Cellular KW - HIV Infections -- immunology KW - Adult KW - HIV Infections -- prevention & control KW - Middle Aged KW - Genes, gag KW - HIV Antibodies -- biosynthesis KW - T-Lymphocytes -- immunology KW - Female KW - Male KW - AIDS Vaccines -- administration & dosage KW - HIV-1 -- genetics KW - HIV-1 -- immunology KW - AIDS Vaccines -- immunology KW - HIV Seronegativity -- immunology KW - AIDS Vaccines -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70360746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.atitle=Safety+and+immunogenicity+of+a+Gag-Pol+candidate+HIV-1+DNA+vaccine+administered+by+a+needle-free+device+in+HIV-1-seronegative+subjects.&rft.au=Tavel%2C+Jorge+A%3BMartin%2C+Julie+E%3BKelly%2C+Grace+G%3BEnama%2C+Mary+E%3BShen%2C+Jean+M%3BGomez%2C+Phillip+L%3BAndrews%2C+Charla+A%3BKoup%2C+Richard+A%3BBailer%2C+Robert+T%3BStein%2C+Judy+A%3BRoederer%2C+Mario%3BNabel%2C+Gary+J%3BGraham%2C+Barney+S&rft.aulast=Tavel&rft.aufirst=Jorge&rft.date=2007-04-15&rft.volume=44&rft.issue=5&rft.spage=601&rft.isbn=&rft.btitle=&rft.title=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.issn=15254135&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-16 N1 - Date created - 2007-04-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Infect Dis. 2006 Dec 15;194(12):1650-60 [17109336] Vaccine. 2000 Nov 22;19(7-8):764-78 [11115698] Nature. 2001 Apr 19;410(6831):1002-7 [11309631] J Virol. 2001 Oct;75(19):9287-96 [11533191] Annu Rev Med. 2002;53:207-21 [11818471] AIDS. 2002 Nov 8;16(16):2137-43 [12409734] J Virol. 2003 Sep;77(18):10113-8 [12941922] MMWR Morb Mortal Wkly Rep. 2003 Nov 28;52(47):1145-8 [14647015] Gene Ther. 2004 Jul;11(14):1146-54 [15103320] J Infect Dis. 1998 Jul;178(1):92-100 [9652427] Science. 1998 Oct 16;282(5388):476-80 [9774275] J Virol. 2005 Jan;79(2):771-9 [15613305] Vaccine. 2005 Mar 18;23(17-18):2066-73 [15755572] Science. 2000 Oct 20;290(5491):486-92 [11039923] Clin Vaccine Immunol. 2006 Nov;13(11):1267-77 [16988008] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Distinct EBV and CMV reactivation patterns following antibody-based immunosuppressive regimens in patients with severe aplastic anemia. AN - 70348685; 17148582 AB - The natural history of EBV and CMV reactivation and the potential for serious complications following antibody-based immunosuppressive treatment for bone marrow failure syndromes in the absence of transplantation is not known. We monitored blood for EBV and CMV reactivation by polymerase chain reaction (PCR) weekly in 78 consecutive patients (total of 99 immunosuppressive courses) with aplastic anemia. Four regimens were studied: (1) HC, horse ATG/cyclosporine; (2) HCS, horse ATG/CsA/sirolimus; (3) RC, rabbit ATG/CsA; and (4) CP, alemtuzumab. There were no cases of EBV or CMV disease, but EBV reactivation occurred in 82 (87%) of 94 and CMV reactivation in 19 (33%) of 57 seropositive patients after starting immunosuppression. The median peak EBV copies were higher in the RC group when compared with HC, HCS, and alemtuzumab (P < .001). The median duration of PCR positivity for EBV was higher in the RC group compared with HC, HCS, and alemtuzumab (P = .001). Subclinical reactivation of both EBV and CMV is common and nearly always self-limited in patients with bone marrow failure receiving immunosuppression; different regimens are associated with different intensity of immunosuppression as measured by viral load and lymphocyte count; and viral reactivation patterns differ according to immunosuppressive regimens. JF - Blood AU - Scheinberg, Phillip AU - Fischer, Steven H AU - Li, Li AU - Nunez, Olga AU - Wu, Colin O AU - Sloand, Elaine M AU - Cohen, Jeffrey I AU - Young, Neal S AU - John Barrett, A AD - Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA. scheinbp@nhlbi.nih.gov Y1 - 2007/04/15/ PY - 2007 DA - 2007 Apr 15 SP - 3219 EP - 3224 VL - 109 IS - 8 SN - 0006-4971, 0006-4971 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Antibodies, Neoplasm KW - Antilymphocyte Serum KW - Antineoplastic Agents KW - DNA, Viral KW - Immunosuppressive Agents KW - alemtuzumab KW - 3A189DH42V KW - Cyclosporine KW - 83HN0GTJ6D KW - Sirolimus KW - W36ZG6FT64 KW - Abridged Index Medicus KW - Index Medicus KW - Sirolimus -- administration & dosage KW - Animals KW - Humans KW - Aged KW - Child KW - Monitoring, Physiologic KW - Cytomegalovirus KW - Herpesvirus 4, Human KW - Antineoplastic Agents -- adverse effects KW - Cyclosporine -- administration & dosage KW - Cyclosporine -- adverse effects KW - Adult KW - DNA, Viral -- blood KW - Adolescent KW - Time Factors KW - Male KW - Antineoplastic Agents -- administration & dosage KW - Antibodies, Neoplasm -- adverse effects KW - Horses KW - Rabbits KW - Antibodies, Neoplasm -- administration & dosage KW - Antibodies, Monoclonal -- administration & dosage KW - Child, Preschool KW - Sirolimus -- adverse effects KW - Polymerase Chain Reaction KW - Immunosuppression -- adverse effects KW - Antibodies, Monoclonal -- adverse effects KW - Middle Aged KW - Female KW - Antilymphocyte Serum -- adverse effects KW - Anemia, Aplastic -- complications KW - Anemia, Aplastic -- blood KW - Epstein-Barr Virus Infections -- blood KW - Anemia, Aplastic -- virology KW - Virus Activation -- drug effects KW - Cytomegalovirus Infections -- blood KW - Anemia, Aplastic -- drug therapy KW - Antilymphocyte Serum -- administration & dosage KW - Cytomegalovirus Infections -- chemically induced KW - Epstein-Barr Virus Infections -- chemically induced KW - Immunosuppressive Agents -- administration & dosage KW - Immunosuppressive Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70348685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Distinct+EBV+and+CMV+reactivation+patterns+following+antibody-based+immunosuppressive+regimens+in+patients+with+severe+aplastic+anemia.&rft.au=Scheinberg%2C+Phillip%3BFischer%2C+Steven+H%3BLi%2C+Li%3BNunez%2C+Olga%3BWu%2C+Colin+O%3BSloand%2C+Elaine+M%3BCohen%2C+Jeffrey+I%3BYoung%2C+Neal+S%3BJohn+Barrett%2C+A&rft.aulast=Scheinberg&rft.aufirst=Phillip&rft.date=2007-04-15&rft.volume=109&rft.issue=8&rft.spage=3219&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-23 N1 - Date created - 2007-04-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Blood. 1995 Jun 1;85(11):3058-65 [7756640] J Am Acad Dermatol. 1992 May;26(5 Pt 2):836-40 [1613146] Am J Hematol. 1996 Jun;52(2):108-13 [8638630] J Gen Virol. 1995 Apr;76 ( Pt 4):741-50 [9049319] Clin Infect Dis. 1998 Jan;26(1):209-10 [9455550] Transplantation. 1998 Jul 15;66(1):29-37 [9679818] Transplantation. 1999 Apr 15;67(7):1011-8 [10221486] J Natl Cancer Inst. 2004 Nov 17;96(22):1691-702 [15547182] Br J Haematol. 2005 Apr;129(2):229-39 [15813851] Int J Dev Biol. 2005;49(2-3):285-92 [15906243] J Clin Microbiol. 2005 Jul;43(7):3540-3 [16000501] Blood. 2006 Feb 1;107(3):862-9 [16234359] Bone Marrow Transplant. 2006 Mar;37(5):503-10 [16415894] Am J Hematol. 2006 May;81(5):355-7 [16628717] Transfusion. 2006 Oct;46(10):1754-62 [17002632] Blood. 2006 Oct 15;108(8):2509-19 [16778145] Blood. 2006 Oct 15;108(8):2874-80 [16804113] Semin Hematol. 2000 Jan;37(1):56-68 [10676911] Annu Rev Microbiol. 2000;54:19-48 [11018123] Blood. 2001 Aug 1;98(3):891-2 [11482318] Blood. 2002 Jun 15;99(12):4357-63 [12036862] Blood. 2002 Jun 15;99(12):4364-9 [12036863] Blood. 2003 Jun 1;101(11):4290-7 [12576337] Bone Marrow Transplant. 2003 Jun;31(11):1023-5 [12774054] Leuk Lymphoma. 2003 Aug;44(8):1367-78 [12952231] Biol Blood Marrow Transplant. 2003 Sep;9(9):583-91 [14506660] J Infect Dis. 2003 Oct 1;188(7):967-72 [14513415] Leukemia. 2003 Dec;17(12):2537-8 [14523463] Leukemia. 2004 Mar;18(3):484-90 [14749699] Haematologica. 2004 Oct;89(10):1248-52 [15477211] Scand J Haematol. 1978 Jan;20(1):52-6 [625631] Blood. 1979 Apr;53(4):652-65 [426912] J Clin Lab Immunol. 1983 Jan;10(1):25-8 [6600793] N Engl J Med. 1983 Aug 4;309(5):313-4 [6866059] Transplant Proc. 1984 Dec;16(6):1561-3 [6239426] Ann Intern Med. 1988 Nov 1;109(9):695-704 [2847613] Transplantation. 1992 Jan;53(1):68-72 [1310173] Comment In: Blood. 2008 Feb 1;111(3):1739; author reply 1739-40 [18223173] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Signal transduction pathways of tumor necrosis factor--mediated lung injury induced by ozone in mice. AN - 70340349; 17255564 AB - Increasing evidence suggests that tumor necrosis factor (TNF)-alpha plays a key role in pulmonary injury caused by environmental ozone (O(3)) in animal models and human subjects. We previously determined that mice genetically deficient in TNF response are protected from lung inflammation and epithelial injury after O(3) exposure. The present study was designed to determine the molecular mechanisms of TNF receptor (TNF-R)-mediated lung injury induced by O(3). TNF-R knockout (Tnfr(-/-)) and wild-type (Tnfr(+/+)) mice were exposed to 0.3 ppm O(3) or air (for 6, 24, or 48 h), and lung RNA and proteins were prepared. Mice deficient in p50 nuclear factor (NF)-kappaB (Nfkb1(-/-)) or c-Jun-NH(2) terminal kinase 1 (Jnk1(-/-)) and wild-type controls (Nfkb1(+/+), Jnk1(+/+)) were exposed to O(3) (48 h), and the role of NF-kappaB and mitogen-activated protein kinase (MAPK) as downstream effectors of lung injury was analyzed by bronchoalveolar lavage analyses. O(3)-induced early activation of TNF-R adaptor complex formation was attenuated in Tnfr(-/-) mice compared with Tnfr(+/+) mice. O(3) significantly activated lung NF-kappaB in Tnfr(+/+) mice before the development of lung injury. Basal and O(3)-induced NF-kappaB activity was suppressed in Tnfr(-/-) mice. Compared with Tnfr(+/+) mice, MAPKs and activator protein (AP)-1 were lower in Tnfr(-/-) mice basally and after O(3). Furthermore, inflammatory cytokines, including macrophage inflammatory protein-2, were differentially expressed in Tnfr(-/-) and Tnfr(+/+) mice after O(3). O(3)-induced lung injury was significantly reduced in Nfkb1(-/-) and Jnk1(-/-) mice relative to respective control animals. Results suggest that NF-kappaB and MAPK/AP-1 signaling pathways are essential in TNF-R-mediated pulmonary toxicity induced by O(3). JF - American journal of respiratory and critical care medicine AU - Cho, Hye-Youn AU - Morgan, Daniel L AU - Bauer, Alison K AU - Kleeberger, Steven R AD - Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Building 101, MD D-201, Research Triangle Park, NC 27709, USA. cho2@niehs.nih.gov Y1 - 2007/04/15/ PY - 2007 DA - 2007 Apr 15 SP - 829 EP - 839 VL - 175 IS - 8 SN - 1073-449X, 1073-449X KW - NF-kappa B KW - 0 KW - TNF Receptor-Associated Factor 2 KW - Transcription Factor AP-1 KW - Tumor Necrosis Factor-alpha KW - Ozone KW - 66H7ZZK23N KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - TNF Receptor-Associated Factor 2 -- physiology KW - Mice KW - NF-kappa B -- physiology KW - Mitogen-Activated Protein Kinases -- physiology KW - Transcription Factor AP-1 -- physiology KW - Mice, Knockout KW - Signal Transduction -- physiology KW - Tumor Necrosis Factor-alpha -- physiology KW - Respiratory Distress Syndrome, Adult -- chemically induced KW - Ozone -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70340349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+and+critical+care+medicine&rft.atitle=Signal+transduction+pathways+of+tumor+necrosis+factor--mediated+lung+injury+induced+by+ozone+in+mice.&rft.au=Cho%2C+Hye-Youn%3BMorgan%2C+Daniel+L%3BBauer%2C+Alison+K%3BKleeberger%2C+Steven+R&rft.aulast=Cho&rft.aufirst=Hye-Youn&rft.date=2007-04-15&rft.volume=175&rft.issue=8&rft.spage=829&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+and+critical+care+medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-05 N1 - Date created - 2007-04-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 1999 Dec 15;163(12):6827-33 [10586083] Am J Respir Crit Care Med. 2004 Feb 15;169(4):518-24 [14644930] Am J Respir Cell Mol Biol. 2000 May;22(5):620-7 [10783135] Immunity. 2000 Apr;12(4):419-29 [10795740] Am J Epidemiol. 2000 Apr 15;151(8):798-810 [10965977] Am J Physiol Lung Cell Mol Physiol. 2001 Mar;280(3):L537-46 [11159038] Proc Natl Acad Sci U S A. 1988 Sep;85(18):6701-5 [3045822] Mol Cell Biol. 1990 Apr;10(4):1498-506 [2181276] J Biol Chem. 1992 Nov 5;267(31):22102-7 [1429562] J Immunol. 1993 Jun 1;150(11):4996-5012 [8496601] Am J Respir Crit Care Med. 1994 Sep;150(3):676-83 [8087337] Am J Respir Cell Mol Biol. 1995 Jul;13(1):60-8 [7598938] Science. 1995 Sep 8;269(5229):1424-7 [7544915] J Toxicol Environ Health. 1995 Nov;46(3):329-42 [7473861] FEBS Lett. 1996 Feb 5;379(3):265-8 [8603703] J Toxicol Environ Health. 1997 Feb 7;50(2):143-57 [9048958] EMBO J. 1997 Mar 3;16(5):1080-92 [9118946] Am J Physiol. 1997 Mar;272(3 Pt 1):L504-11 [9124608] Nat Genet. 1997 Dec;17(4):475-8 [9398854] Am J Respir Cell Mol Biol. 1998 May;18(5):696-705 [9569240] J Exp Med. 1998 Nov 2;188(9):1739-50 [9802985] Am J Respir Cell Mol Biol. 1999 Oct;21(4):510-20 [10502561] Am J Physiol Lung Cell Mol Physiol. 2005 Feb;288(2):L342-9 [15475383] Am J Physiol Lung Cell Mol Physiol. 2005 Feb;288(2):L390-7 [15516495] Am J Respir Crit Care Med. 2005 Jan 15;171(2):171-6 [15486341] Epidemiology. 2005 Mar;16(2):164-74 [15703530] Infect Immun. 2005 Apr;73(4):2075-82 [15784548] Physiol Genomics. 2005 Jun 16;22(1):108-17 [15784698] Am J Respir Crit Care Med. 2006 May 1;173(9):970-6 [16456144] Cell. 2001 Feb 23;104(4):487-501 [11239407] Toxicol Sci. 2001 Apr;60(2):356-62 [11248148] J Immunol. 2001 Aug 1;167(3):1592-600 [11466381] Trends Cell Biol. 2001 Sep;11(9):372-7 [11514191] Am J Respir Crit Care Med. 2001 Aug 15;164(4):602-7 [11520723] Infect Immun. 2001 Nov;69(11):7100-5 [11598086] J Immunol. 2002 Jan 15;168(2):810-5 [11777976] Am J Respir Cell Mol Biol. 2002 Feb;26(2):175-82 [11804867] Eur J Hum Genet. 2002 Jan;10(1):82-5 [11896460] Toxicol Sci. 2002 Aug;68(2):488-97 [12151646] Environ Health Perspect. 2002 Aug;110 Suppl 4:565-8 [12194888] Am J Respir Crit Care Med. 2002 Sep 15;166(6):849-54 [12231496] Toxicol Sci. 2002 Oct;69(2):400-8 [12377989] Am J Respir Crit Care Med. 2002 Oct 15;166(8):1073-7 [12379550] J Infect Dis. 2002 Nov 1;186(9):1199-206 [12402188] Am J Physiol Lung Cell Mol Physiol. 2002 Dec;283(6):L1247-54 [12388356] J Immunol. 2003 Jan 1;170(1):567-74 [12496444] Toxicol Sci. 2003 Mar;72(1):150-7 [12604844] Annu Rev Immunol. 2003;21:335-76 [12524386] Science. 2003 Jun 6;300(5625):1524-5 [12791976] J Immunol. 2004 Apr 1;172(7):4332-41 [15034048] Am J Respir Cell Mol Biol. 2004 Jun;30(6):830-6 [14754758] J Vet Sci. 2004 Jun;5(2):131-7 [15192340] Am J Physiol Lung Cell Mol Physiol. 2004 Aug;287(2):L279-85 [15064226] Am J Respir Crit Care Med. 2004 Sep 1;170(5):492-8 [15184206] Curr Mol Med. 2004 Jun;4(4):439-44 [15354874] Mol Immunol. 2003 Dec;40(9):633-43 [14597166] Am J Respir Cell Mol Biol. 2000 Feb;22(2):147-9 [10657934] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Diplotypes of the human serotonin 1B receptor promoter predict growth hormone responses to sumatriptan in abstinent alcohol-dependent men. AN - 70326824; 17217931 AB - Some studies have associated alcohol dependence (AD) with the human serotonin (5-HT)(1B) receptor (HTR1B). This investigation explored the functional responsivity of HTR1B in abstinent AD men using a sumatriptan challenge, while measuring genetic heterogeneity in the HTR1B promoter. Abstinent AD men (n = 27) and abstinent men without any alcohol use disorder (n = 19) were administered 6 mg of sumatriptan succinate, subcutaneously. Plasma samples collected over the following 2 hours were assayed for growth hormone (GH) concentrations. His DNA was genotyped for the A-161T and T-261G polymorphisms of the HTR1B promoter and diplotypes determined. Integrated GH responses were predicted by interactions of AD and promoter diplotypes, as well as subject ethnicity. The final model accounted for nearly 35% of the variance in GH responses. Post hoc evaluation revealed that AD was associated with a blunting of GH secretion only among individuals with the most common HTR1B diplotype (TT/TT). A blunting of GH responses in abstinent AD men was observed only among those with the most common HTR1B promoter diplotype. Less common promoter diplotypes appeared protective. Controlling for genetic background is a useful augmentation of case-control pharmacological challenge strategies designed to elucidate the psychobiology of AD and other complex disorders. JF - Biological psychiatry AU - Moss, Howard B AU - Hardie, Thomas L AU - Dahl, John P AU - Berrettini, Wade AU - Xu, Ke AD - Center for the Studies of Addiction, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA. mossh@mail.nih.gov Y1 - 2007/04/15/ PY - 2007 DA - 2007 Apr 15 SP - 974 EP - 978 VL - 61 IS - 8 SN - 0006-3223, 0006-3223 KW - Receptor, Serotonin, 5-HT1B KW - 0 KW - Serotonin Receptor Agonists KW - Sumatriptan KW - 8R78F6L9VO KW - Growth Hormone KW - 9002-72-6 KW - Index Medicus KW - Genotype KW - Polymorphism, Genetic KW - Ethnic Groups KW - Humans KW - Chi-Square Distribution KW - Adult KW - Predictive Value of Tests KW - Radioimmunoassay KW - Male KW - Serotonin Receptor Agonists -- administration & dosage KW - Promoter Regions, Genetic KW - Alcoholism -- diagnosis KW - Sumatriptan -- administration & dosage KW - Growth Hormone -- blood KW - Receptor, Serotonin, 5-HT1B -- genetics KW - Alcoholism -- genetics KW - Alcoholism -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70326824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Diplotypes+of+the+human+serotonin+1B+receptor+promoter+predict+growth+hormone+responses+to+sumatriptan+in+abstinent+alcohol-dependent+men.&rft.au=Moss%2C+Howard+B%3BHardie%2C+Thomas+L%3BDahl%2C+John+P%3BBerrettini%2C+Wade%3BXu%2C+Ke&rft.aulast=Moss&rft.aufirst=Howard&rft.date=2007-04-15&rft.volume=61&rft.issue=8&rft.spage=974&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-01 N1 - Date created - 2007-04-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Synthesis and biological activity of 5-aza-ellipticine derivatives. AN - 70325796; 17376678 AB - Novel 5-aza-ellipticine derivatives were synthesized and tested as antitumor agents. The new compounds were prepared more readily than the analogous ellipticine derivatives, which are known to be potent anti-tumor agents Although the novel 5-aza-ellipticine derivatives are not as biologically active as their corresponding ellipticine analogues, the new compounds represent a new, readily accessible class of heteroaromatic catalytic inhibitors of topoisomerase II and possible anti-tumor agents. JF - Bioorganic & medicinal chemistry letters AU - Moody, Deborah L AU - Dyba, Marcin AU - Kosakowska-Cholody, Teresa AU - Tarasova, Nadya I AU - Michejda, Christopher J AD - Structural Biophysics Laboratory, Molecular Aspects of Drug Design Section, Structural Biophysics Laboratory, NCI-Frederick, PO Box B Frederick, MD 21702, USA. Y1 - 2007/04/15/ PY - 2007 DA - 2007 Apr 15 SP - 2380 EP - 2384 VL - 17 IS - 8 SN - 0960-894X, 0960-894X KW - Antineoplastic Agents KW - 0 KW - Aza Compounds KW - Ellipticines KW - Topoisomerase II Inhibitors KW - Index Medicus KW - Aza Compounds -- chemical synthesis KW - Cell Survival -- drug effects KW - Humans KW - Aza Compounds -- pharmacology KW - Inhibitory Concentration 50 KW - Cell Line KW - Structure-Activity Relationship KW - Antineoplastic Agents -- chemical synthesis KW - Ellipticines -- chemical synthesis KW - Antineoplastic Agents -- pharmacology KW - Ellipticines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70325796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+%26+medicinal+chemistry+letters&rft.atitle=Synthesis+and+biological+activity+of+5-aza-ellipticine+derivatives.&rft.au=Moody%2C+Deborah+L%3BDyba%2C+Marcin%3BKosakowska-Cholody%2C+Teresa%3BTarasova%2C+Nadya+I%3BMichejda%2C+Christopher+J&rft.aulast=Moody&rft.aufirst=Deborah&rft.date=2007-04-15&rft.volume=17&rft.issue=8&rft.spage=2380&rft.isbn=&rft.btitle=&rft.title=Bioorganic+%26+medicinal+chemistry+letters&rft.issn=0960894X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-30 N1 - Date created - 2007-04-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Org Chem. 2000 Nov 17;65(23):7977-83 [11073606] Cancer Chemother Pharmacol. 2001 Mar;47(3):241-9 [11320668] Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11520-5 [9751698] J Med Chem. 2005 Jun 30;48(13):4474-81 [15974599] Chem Rev. 2002 Nov;102(11):4303-427 [12428991] Curr Med Chem Anticancer Agents. 2004 Mar;4(2):149-72 [15032720] J Med Chem. 1980 Nov;23(11):1212-6 [7452670] Am J Physiol. 1986 Nov;251(5 Pt 1):G597-601 [3777167] J Biol Chem. 1991 Jan 25;266(3):1820-9 [1846365] Anticancer Drug Des. 1993 Dec;8(6):399-416 [8286009] J Med Chem. 1994 Oct 14;37(21):3503-10 [7932579] J Med Chem. 1995 Aug 4;38(16):3043-52 [7636867] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Role of Autophagy in Caspase-Independent Cell Death T2 - 2007 Keystone Symposia on Autophagy in Health and Disease (Z3) AN - 40600361; 4548389 JF - 2007 Keystone Symposia on Autophagy in Health and Disease (Z3) AU - Lenardo, Michael J Y1 - 2007/04/15/ PY - 2007 DA - 2007 Apr 15 KW - Mortality KW - Cell death KW - Phagocytosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40600361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Autophagy+in+Health+and+Disease+%28Z3%29&rft.atitle=Role+of+Autophagy+in+Caspase-Independent+Cell+Death&rft.au=Lenardo%2C+Michael+J&rft.aulast=Lenardo&rft.aufirst=Michael&rft.date=2007-04-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Autophagy+in+Health+and+Disease+%28Z3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=83 8&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Photoactivatable Proteins Reveal Stress-Dependent Turnover Kinetics of Autophagosomes. T2 - 2007 Keystone Symposia on Autophagy in Health and Disease (Z3) AN - 40600105; 4548367 JF - 2007 Keystone Symposia on Autophagy in Health and Disease (Z3) AU - Hailey, Dale W Y1 - 2007/04/15/ PY - 2007 DA - 2007 Apr 15 KW - Kinetics KW - Phagosomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40600105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Autophagy+in+Health+and+Disease+%28Z3%29&rft.atitle=Photoactivatable+Proteins+Reveal+Stress-Dependent+Turnover+Kinetics+of+Autophagosomes.&rft.au=Hailey%2C+Dale+W&rft.aulast=Hailey&rft.aufirst=Dale&rft.date=2007-04-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Autophagy+in+Health+and+Disease+%28Z3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=83 8&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Smoking Affects Response to Inhaled Corticosteroids or Leukotriene Receptor Antagonists in Asthma AN - 199593446; 17204725 AB - One-quarter to one-third of individuals with asthma smoke, which may affect response to therapy and contribute to poor asthma control. To determine if the response to an inhaled corticosteroid or a leukotriene receptor antagonist is attenuated in individuals with asthma who smoke. In a multicenter, placebo-controlled, double-blind, double-dummy, crossover trial, 44 nonsmokers and 39 light smokers with mild asthma were assigned randomly to treatment twice daily with inhaled beclomethasone and once daily with oral montelukast. Primary outcome was change in prebronchodilator FEV(1) in smokers versus nonsmokers. Secondary outcomes included peak flow, PC(20) methacholine, symptoms, quality of life, and markers of airway inflammation. Despite similar FEV(1), bronchodilator response, and sensitivity to methacholine at baseline, subjects with asthma who smoked had significantly more symptoms, worse quality of life, and lower daily peak flow than nonsmokers. Adherence to therapy did not differ significantly between smokers and nonsmokers, or between treatment arms. Beclomethasone significantly reduced sputum eosinophils and eosinophil cationic protein (ECP) in both smokers and nonsmokers, but increased FEV(1) (170 ml, p = 0.0003) only in nonsmokers. Montelukast significantly increased a.m. peak flow in smokers (12.6 L/min, p = 0.002), but not in nonsmokers. In subjects with mild asthma who smoke, the response to inhaled corticosteroids is attenuated, suggesting that adjustments to standard therapy may be required to attain asthma control. The greater improvement seen in some outcomes in smokers treated with montelukast suggests that leukotrienes may be important in this setting. Larger prospective studies are required to determine whether leukotriene modifiers can be recommended for managing asthma in patients who smoke. JF - American Journal of Respiratory and Critical Care Medicine AU - Lazarus, Stephen C AU - Chinchilli, Vernon M AU - Rollings, Nancy J AU - Boushey, Homer A AU - et al Y1 - 2007/04/15/ PY - 2007 DA - 2007 Apr 15 SP - 783 EP - 90 CY - New York PB - American Thoracic Society VL - 175 IS - 8 SN - 1073449X KW - Medical Sciences--Respiratory Diseases KW - Acetates KW - Glucocorticoids KW - Leukotriene Antagonists KW - Quinolines KW - Beclomethasone KW - montelukast KW - Respiratory Function Tests KW - Double-Blind Method KW - Humans KW - Adult KW - Treatment Outcome KW - Cross-Over Studies KW - Quality of Life KW - Male KW - Female KW - Beclomethasone -- therapeutic use KW - Asthma -- drug therapy KW - Quinolines -- therapeutic use KW - Acetates -- therapeutic use KW - Smoking -- adverse effects KW - Glucocorticoids -- therapeutic use KW - Leukotriene Antagonists -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/199593446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Smoking+Affects+Response+to+Inhaled+Corticosteroids+or+Leukotriene+Receptor+Antagonists+in+Asthma&rft.au=Lazarus%2C+Stephen+C%3BChinchilli%2C+Vernon+M%3BRollings%2C+Nancy+J%3BBoushey%2C+Homer+A%3Bet+al&rft.aulast=Lazarus&rft.aufirst=Stephen&rft.date=2007-04-15&rft.volume=175&rft.issue=8&rft.spage=783&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Thoracic Society Apr 15, 2007 N1 - Last updated - 2017-01-07 ER - TY - JOUR T1 - Base excision repair and the central nervous system. AN - 70416595; 16934943 AB - Reactive oxygen species generated during normal cellular metabolism react with lipids, proteins, and nucleic acid. Evidence indicates that the accumulation of oxidative damage results in cellular dysfunction or deterioration. In particular, oxidative DNA damage can induce mutagenic replicative outcomes, leading to altered cellular function and/or cellular transformation. Additionally, oxidative DNA modifications can block essential biological processes, namely replication and transcription, triggering cell death responses. The major pathway responsible for removing oxidative DNA damage and restoring the integrity of the genome is base excision repair (BER). We highlight herein what is known about BER protein function(s) in the CNS, which in cooperation with the peripheral nervous system operates to control physical responses, motor coordination, and brain operation. Moreover, we describe evidence indicating that defective BER processing can promote post-mitotic (i.e. non-dividing) neuronal cell death and neurodegenerative disease. The focus of the review is on the core mammalian BER participants, i.e. the DNA glycosylases, AP endonuclease 1, DNA polymerase beta, X-ray cross-complementing 1, and the DNA ligases. JF - Neuroscience AU - Wilson, D M AU - McNeill, D R AD - Laboratory of Molecular Gerontology, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. wilsonda@grc.nia.nih.gov Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 SP - 1187 EP - 1200 VL - 145 IS - 4 SN - 0306-4522, 0306-4522 KW - DNA Repair Enzymes KW - EC 6.5.1.- KW - Index Medicus KW - Animals KW - Cell Survival -- genetics KW - DNA Repair Enzymes -- genetics KW - Mitochondria -- enzymology KW - Humans KW - Neurons -- enzymology KW - Neurons -- ultrastructure KW - Mitochondria -- genetics KW - DNA Repair -- genetics KW - Neurodegenerative Diseases -- physiopathology KW - Neurodegenerative Diseases -- genetics KW - Central Nervous System -- physiopathology KW - Neurodegenerative Diseases -- metabolism KW - Central Nervous System -- enzymology KW - Oxidative Stress -- genetics KW - DNA Damage -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70416595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Base+excision+repair+and+the+central+nervous+system.&rft.au=Wilson%2C+D+M%3BMcNeill%2C+D+R&rft.aulast=Wilson&rft.aufirst=D&rft.date=2007-04-14&rft.volume=145&rft.issue=4&rft.spage=1187&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-22 N1 - Date created - 2007-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Calorie restriction in nonhuman primates: assessing effects on brain and behavioral aging. AN - 70416502; 17223278 AB - Dietary caloric restriction (CR) is the only intervention repeatedly demonstrated to retard the onset and incidence of age-related diseases, maintain function, and extend both lifespan and health span in mammals, including brain and behavioral function. In 70 years of study, such beneficial effects have been demonstrated in rodents and lower animals. Recent results emerging from ongoing studies of CR in humans and nonhuman primates suggest that many of the same anti-disease and anti-aging benefits observed in rodent studies may be applicable to long-lived species. Results of studies in rhesus monkeys indicate that CR animals (30% less than controls) are healthier than fully-fed counterparts based on reduced incidence of various diseases, exhibit significantly better indices of predisposition to disease and may be aging at a slower rate based on analysis of selected indices of aging. The current review discusses approaches taken in studies of rhesus monkeys to analyze age-related changes in brain and behavioral function and the impact of CR on these changes. Approaches include analyses of gross and fine locomotor performance as well as brain imaging. In a related study it was observed that short-term CR (6 months) in adult rhesus monkeys can provide protection against a neurotoxic insult. Increasing interest in the CR paradigm will expand its role in demonstrating how nutrition can modulate the rate of aging and the mechanisms responsible for this modulation. JF - Neuroscience AU - Ingram, D K AU - Young, J AU - Mattison, J A AD - Laboratory of Experimental Gerontology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. ingramd@grc.nia.nih.gov Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 SP - 1359 EP - 1364 VL - 145 IS - 4 SN - 0306-4522, 0306-4522 KW - Receptors, Dopamine D2 KW - 0 KW - Index Medicus KW - Animals KW - DNA Damage -- physiology KW - Longevity -- physiology KW - Motor Activity -- physiology KW - Receptors, Dopamine D2 -- metabolism KW - Radionuclide Imaging KW - Neurodegenerative Diseases -- physiopathology KW - Aging -- metabolism KW - Food Deprivation -- physiology KW - Neurodegenerative Diseases -- metabolism KW - Macaca mulatta -- metabolism KW - Macaca mulatta -- genetics KW - Basal Ganglia -- physiopathology KW - Caloric Restriction KW - Aging -- pathology KW - Basal Ganglia -- diagnostic imaging KW - Neurodegenerative Diseases -- prevention & control KW - Basal Ganglia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70416502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Calorie+restriction+in+nonhuman+primates%3A+assessing+effects+on+brain+and+behavioral+aging.&rft.au=Ingram%2C+D+K%3BYoung%2C+J%3BMattison%2C+J+A&rft.aulast=Ingram&rft.aufirst=D&rft.date=2007-04-14&rft.volume=71A&rft.issue=2&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Cytometry+Part+A&rft.issn=15524922&rft_id=info:doi/10.1002%2Fcyto.a.20358 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-22 N1 - Date created - 2007-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Expression of VEGF and N-cadherin in Adrenal Cortical Cancers and a Mouse Xenograft Model to Assess Possible New Therapeutic Targets T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39428915; 4591579 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Veytsman, Irina G AU - Yu, John Y AU - Yang, Sherry X AU - Nguyen, Dat AU - Goldsmith, Merrill AU - Waud, William R AU - Fojo, Tito Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Cancer KW - Xenografts KW - Animal models KW - N-Cadherin KW - Cortex KW - Vascular endothelial growth factor KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39428915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Expression+of+VEGF+and+N-cadherin+in+Adrenal+Cortical+Cancers+and+a+Mouse+Xenograft+Model+to+Assess+Possible+New+Therapeutic+Targets&rft.au=Veytsman%2C+Irina+G%3BYu%2C+John+Y%3BYang%2C+Sherry+X%3BNguyen%2C+Dat%3BGoldsmith%2C+Merrill%3BWaud%2C+William+R%3BFojo%2C+Tito&rft.aulast=Veytsman&rft.aufirst=Irina&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MicroRNA Expression Patterns in Human Prostate Cancer T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39425256; 4593252 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Hudson, Robert S AU - Prueitt, Robyn L AU - Yi, Ming AU - Howe, Tiffany M AU - Stefano, Volinia AU - Liu, Chang-Gong AU - Stephens, Robert M AU - Calin, George A AU - Croce, Carlo M AU - Ambs, Stefan Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Prostate cancer KW - MiRNA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39425256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=MicroRNA+Expression+Patterns+in+Human+Prostate+Cancer&rft.au=Hudson%2C+Robert+S%3BPrueitt%2C+Robyn+L%3BYi%2C+Ming%3BHowe%2C+Tiffany+M%3BStefano%2C+Volinia%3BLiu%2C+Chang-Gong%3BStephens%2C+Robert+M%3BCalin%2C+George+A%3BCroce%2C+Carlo+M%3BAmbs%2C+Stefan&rft.aulast=Hudson&rft.aufirst=Robert&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Laminin-1-Derived AG73 Peptide Inhibited Formation of Multicellular Spheroids of Free-Floating Ovarian Cancer Cells T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39413069; 4588110 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Yoshida, Yoshio AU - Kurokawa, Tetuji AU - Kotsuji, Fumikazu AU - Kleinmann, Hynda K Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Ovarian cancer KW - Spheroids KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39413069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Laminin-1-Derived+AG73+Peptide+Inhibited+Formation+of+Multicellular+Spheroids+of+Free-Floating+Ovarian+Cancer+Cells&rft.au=Yoshida%2C+Yoshio%3BKurokawa%2C+Tetuji%3BKotsuji%2C+Fumikazu%3BKleinmann%2C+Hynda+K&rft.aulast=Yoshida&rft.aufirst=Yoshio&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immune Mechanisms in Non-Hodgkin Lymphoma: Joint Effects of the Tumor Necrosis Factor (Tnf) G308A and Interleukin 10 (Il10) T3575A Polymorphisms with Environmental Exposures T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39412402; 4592199 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Wang, Sophia S AU - Cozen, Wendy AU - Cerhan, James R AU - Colt, Joanne AU - Morton, Lindsay M AU - Engels, Eric A AU - Davis, Scott AU - Severson, Richard K AU - Rothman, Nathaniel AU - Chanock, Stephen J AU - Hartge, Patricia Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Lymphoma KW - Interleukin 10 KW - Tumor necrosis factor KW - Tumors KW - Environmental factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39412402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Immune+Mechanisms+in+Non-Hodgkin+Lymphoma%3A+Joint+Effects+of+the+Tumor+Necrosis+Factor+%28Tnf%29+G308A+and+Interleukin+10+%28Il10%29+T3575A+Polymorphisms+with+Environmental+Exposures&rft.au=Wang%2C+Sophia+S%3BCozen%2C+Wendy%3BCerhan%2C+James+R%3BColt%2C+Joanne%3BMorton%2C+Lindsay+M%3BEngels%2C+Eric+A%3BDavis%2C+Scott%3BSeverson%2C+Richard+K%3BRothman%2C+Nathaniel%3BChanock%2C+Stephen+J%3BHartge%2C+Patricia&rft.aulast=Wang&rft.aufirst=Sophia&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polymorphisms in DNA Repair Genes and Risk of Non-Hodgkin Lymphoma in New South Wales, Australia T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39412122; 4592156 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Shen, Min AU - Purdue, Mark P AU - Kricker, Anne AU - Lan, Qing AU - Grulich, Andrew E AU - Vajdic, Claire M AU - Turner, Jennifer AU - Whitby, Denise AU - Chanock, Stephen AU - Rothman, Nathaniel AU - Armstrong, Bruce K Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Australia, New South Wales KW - Lymphoma KW - Gene polymorphism KW - DNA repair KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39412122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Polymorphisms+in+DNA+Repair+Genes+and+Risk+of+Non-Hodgkin+Lymphoma+in+New+South+Wales%2C+Australia&rft.au=Shen%2C+Min%3BPurdue%2C+Mark+P%3BKricker%2C+Anne%3BLan%2C+Qing%3BGrulich%2C+Andrew+E%3BVajdic%2C+Claire+M%3BTurner%2C+Jennifer%3BWhitby%2C+Denise%3BChanock%2C+Stephen%3BRothman%2C+Nathaniel%3BArmstrong%2C+Bruce+K&rft.aulast=Shen&rft.aufirst=Min&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytokine Signaling Pathway Polymorphisms and Risk of AIDS-related Lymphoma T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39410734; 4591103 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Wong, Hui-Lee AU - Martinez-Maza, Otoniel AU - Kaslow, Richard A AU - Jacobson, Lisa P AU - Breen, Elizabeth Crabb AU - Ambinder, Richard AU - Detels, Roger AU - Chmiel, Joan S AU - Rinaldo Jr, Charles R AU - Margolick, Joseph B AU - Chanock, Stephen AU - Rabkin, Charles S Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Lymphoma KW - Signal transduction KW - Cytokines KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39410734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Cytokine+Signaling+Pathway+Polymorphisms+and+Risk+of+AIDS-related+Lymphoma&rft.au=Wong%2C+Hui-Lee%3BMartinez-Maza%2C+Otoniel%3BKaslow%2C+Richard+A%3BJacobson%2C+Lisa+P%3BBreen%2C+Elizabeth+Crabb%3BAmbinder%2C+Richard%3BDetels%2C+Roger%3BChmiel%2C+Joan+S%3BRinaldo+Jr%2C+Charles+R%3BMargolick%2C+Joseph+B%3BChanock%2C+Stephen%3BRabkin%2C+Charles+S&rft.aulast=Wong&rft.aufirst=Hui-Lee&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Variants in Circadian Rhythm Genes and Risk for Prostate Cancer: A Population-based Study in China T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39410670; 4591091 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Chu, Lisa W AU - Zhu, Yong AU - Danforth, Kim N AU - Gao, Yu-Tang AU - Zheng, Tongzhang AU - Chokkalingam, Anand P AU - Sesterhenn, Isabell AU - Shen, Ming-Chang AU - Hsing, Ann W Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - China, People's Rep. KW - Prostate cancer KW - Circadian rhythms KW - Population studies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39410670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Variants+in+Circadian+Rhythm+Genes+and+Risk+for+Prostate+Cancer%3A+A+Population-based+Study+in+China&rft.au=Chu%2C+Lisa+W%3BZhu%2C+Yong%3BDanforth%2C+Kim+N%3BGao%2C+Yu-Tang%3BZheng%2C+Tongzhang%3BChokkalingam%2C+Anand+P%3BSesterhenn%2C+Isabell%3BShen%2C+Ming-Chang%3BHsing%2C+Ann+W&rft.aulast=Chu&rft.aufirst=Lisa&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Id1 is an Essential Transcriptional Regulator of the Hematopoietic Microenvironment T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39407051; 4589147 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Suh, Hyung C AU - Ji, Ming AU - Gooya, John AU - Zheng, Kenneth AU - Klarmann, Kimberly AU - Keller, Jonathan Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Microenvironments KW - Hemopoiesis KW - Transcription KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39407051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Id1+is+an+Essential+Transcriptional+Regulator+of+the+Hematopoietic+Microenvironment&rft.au=Suh%2C+Hyung+C%3BJi%2C+Ming%3BGooya%2C+John%3BZheng%2C+Kenneth%3BKlarmann%2C+Kimberly%3BKeller%2C+Jonathan&rft.aulast=Suh&rft.aufirst=Hyung&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A New Approach for the Treatment of Adrenal Cancer: Testing an Adrenal-specific Adenovirus Suicide Gene Therapy Vector in an Adrenal Cancer Xenograft Model System T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39405880; 4589669 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Goldsmith, Merrill E AU - Waud, William R AU - Fojo, Tito Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Cancer KW - Suicide KW - Xenografts KW - Expression vectors KW - Suicide genes KW - Therapy KW - Adenovirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39405880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=A+New+Approach+for+the+Treatment+of+Adrenal+Cancer%3A+Testing+an+Adrenal-specific+Adenovirus+Suicide+Gene+Therapy+Vector+in+an+Adrenal+Cancer+Xenograft+Model+System&rft.au=Goldsmith%2C+Merrill+E%3BWaud%2C+William+R%3BFojo%2C+Tito&rft.aulast=Goldsmith&rft.aufirst=Merrill&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activity of Topotecan in Combination with Bevacizumab on HIF-1a, Tumor Growth and Angiogenesis in U251-HRE Xenograft Tumors. T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39404312; 4591329 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Rapisarda, Annamaria AU - Hollingshead, Melinda AU - Raffeld, Mark AU - Gehrs, Bradley AU - Borgel, Suzanne AU - Carter, John AU - Zalek, Jessica AU - Shoemaker, Robert H AU - Melillo, Giovanni Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Tumors KW - Xenografts KW - Topotecan KW - Hypoxia-inducible factor 1a KW - Angiogenesis KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39404312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Activity+of+Topotecan+in+Combination+with+Bevacizumab+on+HIF-1a%2C+Tumor+Growth+and+Angiogenesis+in+U251-HRE+Xenograft+Tumors.&rft.au=Rapisarda%2C+Annamaria%3BHollingshead%2C+Melinda%3BRaffeld%2C+Mark%3BGehrs%2C+Bradley%3BBorgel%2C+Suzanne%3BCarter%2C+John%3BZalek%2C+Jessica%3BShoemaker%2C+Robert+H%3BMelillo%2C+Giovanni&rft.aulast=Rapisarda&rft.aufirst=Annamaria&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effect of Intravenous Carboxypeptidase-G2 (CPDG2) on Plasma and Cerebrospinal Fluid (Csf) Methotrexate Concentration [MTX] and on Tissue [MTX] by Microdialysis T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39403842; 4589020 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Jayaprakash, Nalini AU - Widemann, Brigitte C AU - McCully, Cynthia L AU - Balis, Frank M AU - Fox, Elizabeth Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Cerebrospinal fluid KW - Methotrexate KW - Microdialysis KW - Intravenous administration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39403842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=The+Effect+of+Intravenous+Carboxypeptidase-G2+%28CPDG2%29+on+Plasma+and+Cerebrospinal+Fluid+%28Csf%29+Methotrexate+Concentration+%5BMTX%5D+and+on+Tissue+%5BMTX%5D+by+Microdialysis&rft.au=Jayaprakash%2C+Nalini%3BWidemann%2C+Brigitte+C%3BMcCully%2C+Cynthia+L%3BBalis%2C+Frank+M%3BFox%2C+Elizabeth&rft.aulast=Jayaprakash&rft.aufirst=Nalini&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Meat and Meat Mutagens and Risk of Prostate Cancer in the Agricultural Health Study Cohort T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39403164; 4588878 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Koutros, Stella AU - Cross, Amanda J AU - Sandler, Dale P AU - Hoppin, Jane A AU - Ma, Xiaomei AU - Zheng, Tongzhang AU - Alavanja, Michael C.R. AU - Sinha, Rashmi Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Prostate cancer KW - Mutagens KW - Meat KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39403164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Meat+and+Meat+Mutagens+and+Risk+of+Prostate+Cancer+in+the+Agricultural+Health+Study+Cohort&rft.au=Koutros%2C+Stella%3BCross%2C+Amanda+J%3BSandler%2C+Dale+P%3BHoppin%2C+Jane+A%3BMa%2C+Xiaomei%3BZheng%2C+Tongzhang%3BAlavanja%2C+Michael+C.R.%3BSinha%2C+Rashmi&rft.aulast=Koutros&rft.aufirst=Stella&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Xenograft Model of Brain Metastasis of Breast Cancer: Metastatic Tumors and the Brain Microenvironment T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39398384; 4588357 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Fitzgerald, Daniel P AU - Palmieri, Diane AU - Vega-Valle, Eleazar AU - Herring, Jeanne AU - Steeg, Patricia S Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Brain tumors KW - Breast cancer KW - Microenvironments KW - Metastases KW - Xenografts KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39398384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=A+Xenograft+Model+of+Brain+Metastasis+of+Breast+Cancer%3A+Metastatic+Tumors+and+the+Brain+Microenvironment&rft.au=Fitzgerald%2C+Daniel+P%3BPalmieri%2C+Diane%3BVega-Valle%2C+Eleazar%3BHerring%2C+Jeanne%3BSteeg%2C+Patricia+S&rft.aulast=Fitzgerald&rft.aufirst=Daniel&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evolutionary Divergence of Human p53 Binding Sites: Use of High Throughput DNA Binding Assays to Characterize Functional Variation in Cell Cycle and Apoptosis Pathways T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39375664; 4590893 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Bell, Douglas A AU - Horvath, Monica M AU - Noureddine, Maher A Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Cell cycle KW - Apoptosis KW - P53 protein KW - Evolution KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39375664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Evolutionary+Divergence+of+Human+p53+Binding+Sites%3A+Use+of+High+Throughput+DNA+Binding+Assays+to+Characterize+Functional+Variation+in+Cell+Cycle+and+Apoptosis+Pathways&rft.au=Bell%2C+Douglas+A%3BHorvath%2C+Monica+M%3BNoureddine%2C+Maher+A&rft.aulast=Bell&rft.aufirst=Douglas&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification and Characterization of Putative Chk2 Inhibitors T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39375600; 4590878 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Jobson, Andrew G AU - Scudiero, Dominic AU - Cardellina, John AU - Currens, Michael AU - Zhang, Hongliang AU - Shoemaker, Robert AU - Pommier, Yves Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39375600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Identification+and+Characterization+of+Putative+Chk2+Inhibitors&rft.au=Jobson%2C+Andrew+G%3BScudiero%2C+Dominic%3BCardellina%2C+John%3BCurrens%2C+Michael%3BZhang%2C+Hongliang%3BShoemaker%2C+Robert%3BPommier%2C+Yves&rft.aulast=Jobson&rft.aufirst=Andrew&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proteomic Analysis of Control and Nm23-H1 Overexpressing Breast Carcinoma Cells T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39370134; 4591402 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Lee, Jong Heun AU - Horak, Christine E AU - Conrads, Thomas P AU - Veenstra, Timothy D AU - Steeg, Patricia S Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Breast carcinoma KW - Proteomics KW - Nucleoside-diphosphate kinase KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39370134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Proteomic+Analysis+of+Control+and+Nm23-H1+Overexpressing+Breast+Carcinoma+Cells&rft.au=Lee%2C+Jong+Heun%3BHorak%2C+Christine+E%3BConrads%2C+Thomas+P%3BVeenstra%2C+Timothy+D%3BSteeg%2C+Patricia+S&rft.aulast=Lee&rft.aufirst=Jong&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PPARg Ligands Induce Cell Growth Inhibition, Apoptosis and Interact with EGFR Pathway and Inhibitors in Cancer Cells T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39369117; 4592024 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Porcelli, Letizia AU - Azzariti, Amalia AU - Simone, Grazia M AU - Gagliardi, Sara AU - Laghezza, Antonio AU - Fracchiolla, Giuseppe AU - Loiodice, Fulvio AU - Paradiso, Angelo Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Cancer KW - Apoptosis KW - Peroxisome proliferator-activated receptors KW - Epidermal growth factor receptors KW - Ligands KW - Inhibitors KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39369117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=PPARg+Ligands+Induce+Cell+Growth+Inhibition%2C+Apoptosis+and+Interact+with+EGFR+Pathway+and+Inhibitors+in+Cancer+Cells&rft.au=Porcelli%2C+Letizia%3BAzzariti%2C+Amalia%3BSimone%2C+Grazia+M%3BGagliardi%2C+Sara%3BLaghezza%2C+Antonio%3BFracchiolla%2C+Giuseppe%3BLoiodice%2C+Fulvio%3BParadiso%2C+Angelo&rft.aulast=Porcelli&rft.aufirst=Letizia&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Alcohol use, Smoking Habits, and Pancreatic Cancer in the NIH-AARP Cohort T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39363087; 4593474 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Jiao, Li AU - Silverman, Debra AU - Schairer, Catherine AU - Hollenbeck, Albert R AU - Leitzmann, Michael AU - Schatzkin, Arthur AU - Stolzenberg-Solomon, Rachael Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Pancreatic cancer KW - Smoking KW - Alcohols KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39363087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Alcohol+use%2C+Smoking+Habits%2C+and+Pancreatic+Cancer+in+the+NIH-AARP+Cohort&rft.au=Jiao%2C+Li%3BSilverman%2C+Debra%3BSchairer%2C+Catherine%3BHollenbeck%2C+Albert+R%3BLeitzmann%2C+Michael%3BSchatzkin%2C+Arthur%3BStolzenberg-Solomon%2C+Rachael&rft.aulast=Jiao&rft.aufirst=Li&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Regulation of Phosphorylation of Ezrin at T567 is Crucial for Tumor Progression and Metastasis in Osteosarcoma T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39361850; 4591956 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Ren, Ling AU - Hong, Sung-Hyeok AU - Cassavaugh, Jessica AU - Khanna, Chand Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Ezrin KW - Osteosarcoma KW - Tumors KW - Phosphorylation KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39361850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=The+Regulation+of+Phosphorylation+of+Ezrin+at+T567+is+Crucial+for+Tumor+Progression+and+Metastasis+in+Osteosarcoma&rft.au=Ren%2C+Ling%3BHong%2C+Sung-Hyeok%3BCassavaugh%2C+Jessica%3BKhanna%2C+Chand&rft.aulast=Ren&rft.aufirst=Ling&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CXCL16 and CXCR6 may Promote Inflammation-associated Cancer Growth through Autocrine Effects on Cancer Cells and Paracrine Effects on Leukocytes T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39361440; 4591881 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Darash-Yahana, Merav AU - Gillespie, John W AU - Hewitt, Stephen M AU - Chen, Yun-Yun K AU - Maeda, Shin AU - Stein, Ilan AU - Peled, Amnon AU - Pikarsky, Eli AU - Karin, Michael AU - Farber, Joshua M Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Cancer KW - CXCL16 protein KW - Paracrine signalling KW - Leukocytes KW - Autocrine signalling KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39361440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=CXCL16+and+CXCR6+may+Promote+Inflammation-associated+Cancer+Growth+through+Autocrine+Effects+on+Cancer+Cells+and+Paracrine+Effects+on+Leukocytes&rft.au=Darash-Yahana%2C+Merav%3BGillespie%2C+John+W%3BHewitt%2C+Stephen+M%3BChen%2C+Yun-Yun+K%3BMaeda%2C+Shin%3BStein%2C+Ilan%3BPeled%2C+Amnon%3BPikarsky%2C+Eli%3BKarin%2C+Michael%3BFarber%2C+Joshua+M&rft.aulast=Darash-Yahana&rft.aufirst=Merav&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Intra-S-phase Checkpoint Affects Both DNA Replication Initiation and Elongation: Single-cell and -DNA Fiber Analyses T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39360347; 4591505 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Pommier, Yves G AU - Seiler, Jennifer A AU - Conti, Chiara AU - Aladjem, Mirit Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Fibers KW - DNA biosynthesis KW - Replication initiation KW - Elongation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39360347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=The+Intra-S-phase+Checkpoint+Affects+Both+DNA+Replication+Initiation+and+Elongation%3A+Single-cell+and+-DNA+Fiber+Analyses&rft.au=Pommier%2C+Yves+G%3BSeiler%2C+Jennifer+A%3BConti%2C+Chiara%3BAladjem%2C+Mirit&rft.aulast=Pommier&rft.aufirst=Yves&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Protein Stabilizers and Storage Time on the Mass Spectrometry Dynamics of Human Serum Proteins T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39359117; 4592838 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Dhamoon, Amit S AU - Saul, Rick AU - Liu, Chenwei AU - Kohn, Elise C AU - Whiteley, Gordon Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Mass spectroscopy KW - Storage KW - Serum proteins KW - Stabilizers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39359117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Effects+of+Protein+Stabilizers+and+Storage+Time+on+the+Mass+Spectrometry+Dynamics+of+Human+Serum+Proteins&rft.au=Dhamoon%2C+Amit+S%3BSaul%2C+Rick%3BLiu%2C+Chenwei%3BKohn%2C+Elise+C%3BWhiteley%2C+Gordon&rft.aulast=Dhamoon&rft.aufirst=Amit&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuroblastoma Cells Induce Osteoblasts to Increase RANKL Expression T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39358874; 4592736 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - McKee, Amy E AU - Thiele, Carol J Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Neuroblastoma cells KW - Osteoblasts KW - TRANCE protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39358874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Neuroblastoma+Cells+Induce+Osteoblasts+to+Increase+RANKL+Expression&rft.au=McKee%2C+Amy+E%3BThiele%2C+Carol+J&rft.aulast=McKee&rft.aufirst=Amy&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TAX1BP1 is a Regulator of NF-kB and Inflammation in Mice T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39357731; 4593280 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Peloponese Jr, Jean-Marie A AU - Iha, Hidekatsu AU - Yedavalli, Venkat AU - Jeang, Kuan-Teh AU - Smith, C Dahlem AU - Starost, Matthew F Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Mice KW - NF-B protein KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39357731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=TAX1BP1+is+a+Regulator+of+NF-kB+and+Inflammation+in+Mice&rft.au=Peloponese+Jr%2C+Jean-Marie+A%3BIha%2C+Hidekatsu%3BYedavalli%2C+Venkat%3BJeang%2C+Kuan-Teh%3BSmith%2C+C+Dahlem%3BStarost%2C+Matthew+F&rft.aulast=Peloponese+Jr&rft.aufirst=Jean-Marie&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Status of Microfilaments Influences Resistance to Cisplatin in Human Epidermal and Liver Carcinoma Cell Lines T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39357544; 4592250 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Aszalos, Adorjan AU - Yin, Jun-Jie AU - Liang, Xing-Jie AU - Taylor, Barbara AU - Winkovitch, Stephan AU - Garfield, Susan AU - Gottesman, Michael M Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Liver KW - Cisplatin KW - Microfilaments KW - Tumor cell lines KW - Hepatocytes KW - Carcinoma KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39357544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=The+Status+of+Microfilaments+Influences+Resistance+to+Cisplatin+in+Human+Epidermal+and+Liver+Carcinoma+Cell+Lines&rft.au=Aszalos%2C+Adorjan%3BYin%2C+Jun-Jie%3BLiang%2C+Xing-Jie%3BTaylor%2C+Barbara%3BWinkovitch%2C+Stephan%3BGarfield%2C+Susan%3BGottesman%2C+Michael+M&rft.aulast=Aszalos&rft.aufirst=Adorjan&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pediatric Preclinical Testing Program (PPTP) Evaluation of the BCL-2 Inhibitor ABT-263 T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39357446; 4593220 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Smith, Malcolm A AU - Maris, John M AU - Keir, Stephen T AU - Friedman, Henry S AU - Lock, Richard B AU - Carol, Hernan AU - Tajbakhsh, Mayamin AU - Gorlick, Richard AU - Kolb, E Anders AU - Keshelava, Nino AU - Reynolds, C Patrick AU - Morton, Christopher AU - Houghton, Peter J Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Pediatrics KW - Bcl-2 protein KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39357446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Pediatric+Preclinical+Testing+Program+%28PPTP%29+Evaluation+of+the+BCL-2+Inhibitor+ABT-263&rft.au=Smith%2C+Malcolm+A%3BMaris%2C+John+M%3BKeir%2C+Stephen+T%3BFriedman%2C+Henry+S%3BLock%2C+Richard+B%3BCarol%2C+Hernan%3BTajbakhsh%2C+Mayamin%3BGorlick%2C+Richard%3BKolb%2C+E+Anders%3BKeshelava%2C+Nino%3BReynolds%2C+C+Patrick%3BMorton%2C+Christopher%3BHoughton%2C+Peter+J&rft.aulast=Smith&rft.aufirst=Malcolm&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Signatures of Cigarette Smoking in Tumor and Normal Lung Tissue from EAGLE T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39357118; 4592974 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Landi, Maria Teresa AU - Dracheva, Tatiana AU - Rotunno, Melissa AU - Shih, Joanna AU - Dasgupta, Abhijit AU - Consonni, Dario AU - Pesatori, Angela AU - Figueroa, Jonine AU - Wacholder, Sholom AU - Bertazzi, PierAlberto AU - Caporaso, Neil AU - Jen, Jin Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Lung KW - Cigarette smoking KW - Gene expression KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39357118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Gene+Expression+Signatures+of+Cigarette+Smoking+in+Tumor+and+Normal+Lung+Tissue+from+EAGLE&rft.au=Landi%2C+Maria+Teresa%3BDracheva%2C+Tatiana%3BRotunno%2C+Melissa%3BShih%2C+Joanna%3BDasgupta%2C+Abhijit%3BConsonni%2C+Dario%3BPesatori%2C+Angela%3BFigueroa%2C+Jonine%3BWacholder%2C+Sholom%3BBertazzi%2C+PierAlberto%3BCaporaso%2C+Neil%3BJen%2C+Jin&rft.aulast=Landi&rft.aufirst=Maria&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association of a CYP17 Polymorphism with the Overall Survival in Androgen Independent Prostate Cancer Patients T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39356519; 4588796 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Hamada, Akinobu AU - Danesi, Romano AU - Price, Douglas K AU - Sissung, Tristan AU - Chau, Cindy AU - Venzon, David AU - Sparreboom, Alex AU - Duhut, William L AU - Figg, William D Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Prostate cancer KW - Survival KW - Androgens KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39356519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Association+of+a+CYP17+Polymorphism+with+the+Overall+Survival+in+Androgen+Independent+Prostate+Cancer+Patients&rft.au=Hamada%2C+Akinobu%3BDanesi%2C+Romano%3BPrice%2C+Douglas+K%3BSissung%2C+Tristan%3BChau%2C+Cindy%3BVenzon%2C+David%3BSparreboom%2C+Alex%3BDuhut%2C+William+L%3BFigg%2C+William+D&rft.aulast=Hamada&rft.aufirst=Akinobu&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Cancer Genome Atlas (TCGA) Pilot Project T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39356504; 4593586 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Collins, Asha Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Cancer KW - Genomes KW - Atlases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39356504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Medical+Journal&rft.atitle=Making+the+prices+of+new+drugs+fairer&rft.au=Sotelo%2C+Julio&rft.aulast=Sotelo&rft.aufirst=Julio&rft.date=2007-02-01&rft.volume=334&rft.issue=7589&rft.spage=369&rft.isbn=&rft.btitle=&rft.title=British+Medical+Journal&rft.issn=09598138&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CA125 Concentration does not Correlate with Disease Response in a Study of Combination Anti-VEGF Agents T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39356500; 4590227 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Azad, Nilofer S AU - Annunziata, Christina M AU - Minasian, Lori AU - Kotz, Herbert AU - McNally, Deborah AU - Kohn, Elise Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Bioindicators KW - Blood KW - Imaging techniques KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39356500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=CA125+Concentration+does+not+Correlate+with+Disease+Response+in+a+Study+of+Combination+Anti-VEGF+Agents&rft.au=Azad%2C+Nilofer+S%3BAnnunziata%2C+Christina+M%3BMinasian%2C+Lori%3BKotz%2C+Herbert%3BMcNally%2C+Deborah%3BKohn%2C+Elise&rft.aulast=Azad&rft.aufirst=Nilofer&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phyloarray: A Phylogenetic Approach to Cancer Gene-expression Microarray Analysis T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39356218; 4590143 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Abu-Asab, Mones S AU - Chaouchi, Mohamed AU - Amri, Hakima Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Cancer KW - Gene expression KW - DNA microarrays KW - Phylogenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39356218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Phyloarray%3A+A+Phylogenetic+Approach+to+Cancer+Gene-expression+Microarray+Analysis&rft.au=Abu-Asab%2C+Mones+S%3BChaouchi%2C+Mohamed%3BAmri%2C+Hakima&rft.aulast=Abu-Asab&rft.aufirst=Mones&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mutant K-ras, Reactive Oxygen Species and Antioxidants in Human Lung Adenocarcinoma Cells T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39355234; 4591620 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Maciag, Anna AU - Romanowska, Malgorzata AU - Kikawa, Keith D AU - Fields, Janet AU - Kasprzak, Kazimierz S AU - Anderson, Lucy M Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Lung KW - Reactive oxygen species KW - Mutants KW - Antioxidants KW - K-Ras protein KW - Adenocarcinoma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39355234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Mutant+K-ras%2C+Reactive+Oxygen+Species+and+Antioxidants+in+Human+Lung+Adenocarcinoma+Cells&rft.au=Maciag%2C+Anna%3BRomanowska%2C+Malgorzata%3BKikawa%2C+Keith+D%3BFields%2C+Janet%3BKasprzak%2C+Kazimierz+S%3BAnderson%2C+Lucy+M&rft.aulast=Maciag&rft.aufirst=Anna&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cyclooxygenase-2 Generated Prostaglandin E sub(2) Inhibits UVB-Induced Apoptosis in Mouse Skin by Activating the Receptors, EP2 and EP4 T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39354137; 4593288 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Chun, Kyung-Soo AU - Langenbach, Robert Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Skin KW - Apoptosis KW - Cyclooxygenase-2 KW - Prostaglandin E2 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39354137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Cyclooxygenase-2+Generated+Prostaglandin+E+sub%282%29+Inhibits+UVB-Induced+Apoptosis+in+Mouse+Skin+by+Activating+the+Receptors%2C+EP2+and+EP4&rft.au=Chun%2C+Kyung-Soo%3BLangenbach%2C+Robert&rft.aulast=Chun&rft.aufirst=Kyung-Soo&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Applications of RNAi Screens in the Study of Cancer-Associated Processes T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39353736; 4593226 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Martin, Scott E AU - Jones, Tamara L AU - Thomas, Cheryl L AU - Lader, Eric AU - Weinstein, John N AU - Pommier, Yves AU - Huppi, Konrad AU - Caplen, Natasha J Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - RNA-mediated interference KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39353736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Molecular+dynamics+simulation+of+the+P2Y+sub%2814%29+receptor.+Ligand+docking+and+identification+of+a+putative+binding+site+of+the+distal+hexose+moiety&rft.au=Ivanov%2C+Andrei+A%3BFricks%2C+Ingrid%3BHarden%2C+TKendall%3BJacobson%2C+Kenneth+A&rft.aulast=Ivanov&rft.aufirst=Andrei&rft.date=2007-02-01&rft.volume=17&rft.issue=3&rft.spage=761&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2006.10.081 L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Compromised Complement System Increases Colon Cancer Susceptibility in African-Americans T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39353247; 4593072 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Zanetti, Krista A AU - Khan, Mohammed A AU - Bowman, Elise D AU - Goodman, Julie E AU - Bernig, Toralf AU - Chanock, Stephen AU - Harris, Curtis C Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Africa KW - Colon cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39353247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Compromised+Complement+System+Increases+Colon+Cancer+Susceptibility+in+African-Americans&rft.au=Zanetti%2C+Krista+A%3BKhan%2C+Mohammed+A%3BBowman%2C+Elise+D%3BGoodman%2C+Julie+E%3BBernig%2C+Toralf%3BChanock%2C+Stephen%3BHarris%2C+Curtis+C&rft.aulast=Zanetti&rft.aufirst=Krista&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Romidepsin Causes QTc-Interval Prolongation in Mice Lacking Abcb1-Type P-Glycoprotein T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39352902; 4588777 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Sissung, Tristan M AU - Howden, Reuben AU - Li, Haiqing AU - Piekarz, Richard L AU - Bates, Susan E AU - Price, Douglas K AU - Kleeberger, Steven AU - Sparreboom, Alex AU - Figg, William D Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Mice KW - P-Glycoprotein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39352902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Romidepsin+Causes+QTc-Interval+Prolongation+in+Mice+Lacking+Abcb1-Type+P-Glycoprotein&rft.au=Sissung%2C+Tristan+M%3BHowden%2C+Reuben%3BLi%2C+Haiqing%3BPiekarz%2C+Richard+L%3BBates%2C+Susan+E%3BPrice%2C+Douglas+K%3BKleeberger%2C+Steven%3BSparreboom%2C+Alex%3BFigg%2C+William+D&rft.aulast=Sissung&rft.aufirst=Tristan&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Immunotoxins Targeting CD123, a Stem Cell Antigen on Acute Myeloid Leukemia Cells T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39352116; 4593154 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Du, Xing AU - Ho, Mitchell AU - Pastan, Ira Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Stem cells KW - Acute myeloid leukemia KW - Immunotoxins KW - CD123 antigen KW - Antigens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39352116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=New+Immunotoxins+Targeting+CD123%2C+a+Stem+Cell+Antigen+on+Acute+Myeloid+Leukemia+Cells&rft.au=Du%2C+Xing%3BHo%2C+Mitchell%3BPastan%2C+Ira&rft.aulast=Du&rft.aufirst=Xing&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - GST Genotypes and Lung Cancer Susceptibility in Asian Populations with Indoor Air Pollution Exposures: A Meta-analysis T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39351844; 4591083 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Hosgood III, H. Dean AU - Berndt, Sonja I AU - Lan, Qing Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Lung cancer KW - Indoor air pollution KW - Genotypes KW - Reviews KW - Air pollution KW - Air exposure KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39351844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=The+discovery+of+transcriptional+modules+by+a+two-stage+matrix+decomposition+approach&rft.au=Li%2C+Huai%3BSun%2C+Yu%3BZhan%2C+Ming&rft.aulast=Li&rft.aufirst=Huai&rft.date=2007-02-01&rft.volume=23&rft.issue=4&rft.spage=473&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Gene Signature in Prostate Tumors Differentiates African American and Caucasian Men T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39351783; 4591052 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Wallace, Tiffany A AU - Prueitt, Robyn L AU - Yi, Ming AU - Stephens, Robert M AU - Ambs, Stefan Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Africa KW - Ethnic groups KW - Prostate KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39351783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=A+Gene+Signature+in+Prostate+Tumors+Differentiates+African+American+and+Caucasian+Men&rft.au=Wallace%2C+Tiffany+A%3BPrueitt%2C+Robyn+L%3BYi%2C+Ming%3BStephens%2C+Robert+M%3BAmbs%2C+Stefan&rft.aulast=Wallace&rft.aufirst=Tiffany&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Compensatory Mechanisms Lead to Enhanced Oncogenesis in Tpl2 Knock Out Mouse Skin T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39351560; 4592801 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Pandey, Jyotsna AU - Simmons, John K AU - Shan, Zhihong AU - Wiest, Jonathan S Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Lead KW - Skin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39351560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Compensatory+Mechanisms+Lead+to+Enhanced+Oncogenesis+in+Tpl2+Knock+Out+Mouse+Skin&rft.au=Pandey%2C+Jyotsna%3BSimmons%2C+John+K%3BShan%2C+Zhihong%3BWiest%2C+Jonathan+S&rft.aulast=Pandey&rft.aufirst=Jyotsna&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Profiling of Microdissected Stroma from Normal Ovary and Ovarian Tumors Reveals Altered Expression of Genes Implicated in Adhesion and Angiogenesis T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39351132; 4592702 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Samimi, Goli AU - Bonome, Tomas AU - Radonovich, Mike AU - Pise-Masison, Cindy AU - Brady, John AU - Ghosh, Sue AU - Ng, Shu-wing AU - Mok, Samuel C AU - Birrer, Michael J Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Adhesion KW - Gene expression KW - Ovaries KW - Stroma KW - Tumors KW - Angiogenesis KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39351132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Gene+Expression+Profiling+of+Microdissected+Stroma+from+Normal+Ovary+and+Ovarian+Tumors+Reveals+Altered+Expression+of+Genes+Implicated+in+Adhesion+and+Angiogenesis&rft.au=Samimi%2C+Goli%3BBonome%2C+Tomas%3BRadonovich%2C+Mike%3BPise-Masison%2C+Cindy%3BBrady%2C+John%3BGhosh%2C+Sue%3BNg%2C+Shu-wing%3BMok%2C+Samuel+C%3BBirrer%2C+Michael+J&rft.aulast=Samimi&rft.aufirst=Goli&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Multidrug Transporter ABCG2: A Molecular Target during Early Stages of Development of Multidrug Resistance in Breast Cancer Cells T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39350024; 4592256 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Calcagno, Anna Maria AU - Fostel, Jennifer M AU - To, Kenneth W AU - Martin, Scott E AU - Chewning, Katherine J AU - Wu, Chung-Pu AU - Bates, Susan AU - Caplen, Natasha J AU - Ambudkar, Suresh V Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Breast cancer KW - Multidrug resistance KW - Developmental stages KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39350024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=The+Multidrug+Transporter+ABCG2%3A+A+Molecular+Target+during+Early+Stages+of+Development+of+Multidrug+Resistance+in+Breast+Cancer+Cells&rft.au=Calcagno%2C+Anna+Maria%3BFostel%2C+Jennifer+M%3BTo%2C+Kenneth+W%3BMartin%2C+Scott+E%3BChewning%2C+Katherine+J%3BWu%2C+Chung-Pu%3BBates%2C+Susan%3BCaplen%2C+Natasha+J%3BAmbudkar%2C+Suresh+V&rft.aulast=Calcagno&rft.aufirst=Anna&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NGEP-L, a Prostate Specific Plasma Membrane Protein, is a New Target for Prostate Cancer Immunotherapy T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39349043; 4590740 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Das, Sudipto AU - Hahn, Yansoo AU - Bera, Tapan AU - Nagata, Satoshi AU - Willingham, Mark C AU - Lee, Byungkook AU - Pastan, Ira Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Immunotherapy KW - Prostate cancer KW - Plasma membranes KW - Membrane proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39349043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=NGEP-L%2C+a+Prostate+Specific+Plasma+Membrane+Protein%2C+is+a+New+Target+for+Prostate+Cancer+Immunotherapy&rft.au=Das%2C+Sudipto%3BHahn%2C+Yansoo%3BBera%2C+Tapan%3BNagata%2C+Satoshi%3BWillingham%2C+Mark+C%3BLee%2C+Byungkook%3BPastan%2C+Ira&rft.aulast=Das&rft.aufirst=Sudipto&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Farnesol Induced Cell Death via Endoplasmic Reticulum (ER) Stress Response in Human Lung Carcinoma Cells through MEK Activation. T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39348915; 4590715 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Joo, Joung Hyuck AU - Liao, Grace AU - Bird, Gary AU - Obie, Johnny AU - Jetten, Anton M Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Lung KW - Stress KW - Mortality KW - Cell death KW - Farnesol KW - Endoplasmic reticulum KW - Lung carcinoma KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39348915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Farnesol+Induced+Cell+Death+via+Endoplasmic+Reticulum+%28ER%29+Stress+Response+in+Human+Lung+Carcinoma+Cells+through+MEK+Activation.&rft.au=Joo%2C+Joung+Hyuck%3BLiao%2C+Grace%3BBird%2C+Gary%3BObie%2C+Johnny%3BJetten%2C+Anton+M&rft.aulast=Joo&rft.aufirst=Joung&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Variation in Insulin-like Growth Factor-1 Influences Risk of Colorectal Cancer. T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39347456; 4590312 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Wong, Hui-Lee AU - Koh, Woon-Puay AU - Probst-Hensch, Nicole M AU - Van den Berg, David AU - Yu, Mimi C AU - Ingles, Sue A Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Colorectal cancer KW - Genetic diversity KW - Insulin-like growth factor I KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39347456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Genetic+Variation+in+Insulin-like+Growth+Factor-1+Influences+Risk+of+Colorectal+Cancer.&rft.au=Wong%2C+Hui-Lee%3BKoh%2C+Woon-Puay%3BProbst-Hensch%2C+Nicole+M%3BVan+den+Berg%2C+David%3BYu%2C+Mimi+C%3BIngles%2C+Sue+A&rft.aulast=Wong&rft.aufirst=Hui-Lee&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of the Metastatic Potential of the Osteosarcoma Cell Lines by the Src/Abl Kinase Inhibitor AZD0530 T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39347375; 4592526 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Campbell, Kirk A AU - Ren, Ling AU - Hong, Sung-Hyeok AU - Helman, Lee J AU - Khanna, Chand Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Src protein KW - Osteosarcoma cells KW - Metastases KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39347375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Inhibition+of+the+Metastatic+Potential+of+the+Osteosarcoma+Cell+Lines+by+the+Src%2FAbl+Kinase+Inhibitor+AZD0530&rft.au=Campbell%2C+Kirk+A%3BRen%2C+Ling%3BHong%2C+Sung-Hyeok%3BHelman%2C+Lee+J%3BKhanna%2C+Chand&rft.aulast=Campbell&rft.aufirst=Kirk&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reverse-Phase Protein Microarrays: Biotin-Free Signal Amplification Enhances Specificity for Clinical Proteomics T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39347163; 4592839 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Devor, Christopher B AU - Mundinger, Gerhard S AU - Bandle, Russel AU - Alexander Jr, Richard H AU - Pingpank, James F AU - Calvo, Katherine R Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Protein arrays KW - Proteomics KW - Specificity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39347163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Reverse-Phase+Protein+Microarrays%3A+Biotin-Free+Signal+Amplification+Enhances+Specificity+for+Clinical+Proteomics&rft.au=Devor%2C+Christopher+B%3BMundinger%2C+Gerhard+S%3BBandle%2C+Russel%3BAlexander+Jr%2C+Richard+H%3BPingpank%2C+James+F%3BCalvo%2C+Katherine+R&rft.aulast=Devor&rft.aufirst=Christopher&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synergistic Effect of Curcumin and COX-2 Inhibition in Regulating Colon Cancer Cell Proliferation T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39346254; 4591411 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Murmu, Nabendu AU - Ramalingam, Satish AU - Subramaniam, Dharmalingam AU - Wyche, James AU - Houchen, Courtney AU - Anant, Shrikant Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Colon cancer KW - Cell proliferation KW - Curcumin KW - Cyclooxygenase-2 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39346254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Synergistic+Effect+of+Curcumin+and+COX-2+Inhibition+in+Regulating+Colon+Cancer+Cell+Proliferation&rft.au=Murmu%2C+Nabendu%3BRamalingam%2C+Satish%3BSubramaniam%2C+Dharmalingam%3BWyche%2C+James%3BHouchen%2C+Courtney%3BAnant%2C+Shrikant&rft.aulast=Murmu&rft.aufirst=Nabendu&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DMBA Treatment of Heterozygous MMTV-Neu and MMTV-Neu/P53 Knockout Mice: Histopathologic Characterization, Array Analysis, and Chemopreventive Efficacy of Rexinoids. T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39346178; 4592410 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Lubet, Ronald A AU - Ruppert, Michael J AU - Kapetanovic, Izet M AU - Perou, Charles M AU - Juliana, Margaret M AU - Grubbs, Clinton J Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Mice KW - P53 protein KW - 9,10-Dimethyl-1,2-benzanthracene KW - Histopathology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39346178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=DMBA+Treatment+of+Heterozygous+MMTV-Neu+and+MMTV-Neu%2FP53+Knockout+Mice%3A+Histopathologic+Characterization%2C+Array+Analysis%2C+and+Chemopreventive+Efficacy+of+Rexinoids.&rft.au=Lubet%2C+Ronald+A%3BRuppert%2C+Michael+J%3BKapetanovic%2C+Izet+M%3BPerou%2C+Charles+M%3BJuliana%2C+Margaret+M%3BGrubbs%2C+Clinton+J&rft.aulast=Lubet&rft.aufirst=Ronald&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identifying the SLC Transporters that Confer Drug Sensitivity to Cancer Cells T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39346048; 4592214 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Okabe, Mitsunori AU - Szakacs, Gergely AU - Suzuki, Toshihiro AU - Reimers, Mark AU - Gottesman, Michael M Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Cancer KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39346048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Identifying+the+SLC+Transporters+that+Confer+Drug+Sensitivity+to+Cancer+Cells&rft.au=Okabe%2C+Mitsunori%3BSzakacs%2C+Gergely%3BSuzuki%2C+Toshihiro%3BReimers%2C+Mark%3BGottesman%2C+Michael+M&rft.aulast=Okabe&rft.aufirst=Mitsunori&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Methylation of Isolated CpGs of the GSTP1 Promoter in Non-Neoplastic Prostate Tissues: Possible Early Preneoplastic Changes? T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39345827; 4588461 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Rodriguez, Jaime AU - Richardson, Annely M AU - Hanson, Jeffrey C AU - Novakovic, Kristian AU - Erickson, Heidi S AU - Linehan, W Marston AU - Pinto, Peter A AU - Merino, Maria J AU - Woodson, Karen G AU - Bova, G Steven AU - Emmert-Buck, Michael R AU - Chuaqui, Rodrigo F Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Prostate KW - Promoters KW - Glutathione transferase KW - DNA methylation KW - CpG islands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39345827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Methylation+of+Isolated+CpGs+of+the+GSTP1+Promoter+in+Non-Neoplastic+Prostate+Tissues%3A+Possible+Early+Preneoplastic+Changes%3F&rft.au=Rodriguez%2C+Jaime%3BRichardson%2C+Annely+M%3BHanson%2C+Jeffrey+C%3BNovakovic%2C+Kristian%3BErickson%2C+Heidi+S%3BLinehan%2C+W+Marston%3BPinto%2C+Peter+A%3BMerino%2C+Maria+J%3BWoodson%2C+Karen+G%3BBova%2C+G+Steven%3BEmmert-Buck%2C+Michael+R%3BChuaqui%2C+Rodrigo+F&rft.aulast=Rodriguez&rft.aufirst=Jaime&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Endometrial Carcinoma Risk in Women Diagnosed with Endometrial Hyperplasia T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39344783; 4591045 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Lacey Jr, James V AU - Ioffe, Olga B AU - Ronnett, Brigitte M AU - Richesson, Douglas A AU - Rush, Brenda B AU - Glass, Andrew G AU - Chatterjee, Nilanjan AU - Sherman, Mark E Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Endometrium KW - Hyperplasia KW - Carcinoma KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39344783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Endometrial+Carcinoma+Risk+in+Women+Diagnosed+with+Endometrial+Hyperplasia&rft.au=Lacey+Jr%2C+James+V%3BIoffe%2C+Olga+B%3BRonnett%2C+Brigitte+M%3BRichesson%2C+Douglas+A%3BRush%2C+Brenda+B%3BGlass%2C+Andrew+G%3BChatterjee%2C+Nilanjan%3BSherman%2C+Mark+E&rft.aulast=Lacey+Jr&rft.aufirst=James&rft.date=2007-04-14&rft.volume=18&rft.issue=2&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Anti-cancer+drugs&rft.issn=09594973&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cross-species Functional Genomic Analysis Reveals Key Role of MYC in Early Human Hepatocarcinogenesis T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39343367; 4590901 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Kaposi-Novak, Pal AU - Libbrecht, Louis AU - Coulouarn, Cedric AU - Sears, Nathaniel C AU - Factor, Valentina M AU - Roskams, Tania AU - Thorgeirsson, Snorri S Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Genomic analysis KW - Myc protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39343367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Cross-species+Functional+Genomic+Analysis+Reveals+Key+Role+of+MYC+in+Early+Human+Hepatocarcinogenesis&rft.au=Kaposi-Novak%2C+Pal%3BLibbrecht%2C+Louis%3BCoulouarn%2C+Cedric%3BSears%2C+Nathaniel+C%3BFactor%2C+Valentina+M%3BRoskams%2C+Tania%3BThorgeirsson%2C+Snorri+S&rft.aulast=Kaposi-Novak&rft.aufirst=Pal&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Viral Load Signatures for HBV and HCV in Human Hepatocellular Carcinoma T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39343311; 4590889 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Woo, Hyun Goo AU - Van Pelt, Ing Jos F. AU - Lee, Ju-Seog AU - Verslype, Chris AU - Libbrecht, Louis AU - Chu, In-Sun AU - Thorgeirsson, Snorri Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Hepatocellular carcinoma KW - Tumors KW - Hepatitis B virus KW - Hepatitis C virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39343311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Identification+of+Viral+Load+Signatures+for+HBV+and+HCV+in+Human+Hepatocellular+Carcinoma&rft.au=Woo%2C+Hyun+Goo%3BVan+Pelt%2C+Ing+Jos+F.%3BLee%2C+Ju-Seog%3BVerslype%2C+Chris%3BLibbrecht%2C+Louis%3BChu%2C+In-Sun%3BThorgeirsson%2C+Snorri&rft.aulast=Woo&rft.aufirst=Hyun&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microarray Analysis of Ras Transformed Keratinocytes Genetically or Pharmacologically Ablated for the Epidermal Growth Factor Receptor (EGFR) Reveals Potential Alternative Target Pathways and Off Target Drug Effects T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39342844; 4590423 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Wright, Lisa N AU - Ryscavage, Andrew AU - Yuspa, Stuart H Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Drugs KW - Growth factors KW - Epidermal growth factor receptors KW - Ras protein KW - Keratinocytes KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39342844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Microarray+Analysis+of+Ras+Transformed+Keratinocytes+Genetically+or+Pharmacologically+Ablated+for+the+Epidermal+Growth+Factor+Receptor+%28EGFR%29+Reveals+Potential+Alternative+Target+Pathways+and+Off+Target+Drug+Effects&rft.au=Wright%2C+Lisa+N%3BRyscavage%2C+Andrew%3BYuspa%2C+Stuart+H&rft.aulast=Wright&rft.aufirst=Lisa&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pilot Test of a New Genotyping Platform, the Affymetrix Drug Metabolizing Enzymes and Transporter (Dme-T) Panel, for Cancer and Pharmacogenomic Research T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39342806; 4588140 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Deeken, John F AU - Cormier, Trena AU - Price, Douglas K AU - Steinberg, Seth AU - Tran, Karen AU - Liewehr, David J AU - Hardenbol, Paul AU - Dahut, William AU - Miao, Xin AU - Figg, W Douglas Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Cancer KW - Drugs KW - Enzymes KW - Genotyping KW - Pharmacogenomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39342806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Pilot+Test+of+a+New+Genotyping+Platform%2C+the+Affymetrix+Drug+Metabolizing+Enzymes+and+Transporter+%28Dme-T%29+Panel%2C+for+Cancer+and+Pharmacogenomic+Research&rft.au=Deeken%2C+John+F%3BCormier%2C+Trena%3BPrice%2C+Douglas+K%3BSteinberg%2C+Seth%3BTran%2C+Karen%3BLiewehr%2C+David+J%3BHardenbol%2C+Paul%3BDahut%2C+William%3BMiao%2C+Xin%3BFigg%2C+W+Douglas&rft.aulast=Deeken&rft.aufirst=John&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Polymorphisms in p53 Response Elements are Associated with Colorectal Adenoma Risk T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39342385; 4590313 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Berndt, Sonja I AU - Huang, Wen-Yi AU - Yeager, Meredith AU - Chanock, Stephen J AU - Reding, Douglas AU - Hayes, Richard B Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Colorectal cancer KW - Regulatory sequences KW - P53 protein KW - Adenoma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39342385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Functional+Polymorphisms+in+p53+Response+Elements+are+Associated+with+Colorectal+Adenoma+Risk&rft.au=Berndt%2C+Sonja+I%3BHuang%2C+Wen-Yi%3BYeager%2C+Meredith%3BChanock%2C+Stephen+J%3BReding%2C+Douglas%3BHayes%2C+Richard+B&rft.aulast=Berndt&rft.aufirst=Sonja&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lung Cancer Risk after Detection of Granulomas or Scarring on Chest Radiograph T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39342152; 4588041 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Yu, Ying-Ying AU - Caporaso, Neil E AU - Pinsky, Paul F AU - Chatterjee, Nilanjan AU - Engels, Eric A Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Lung cancer KW - Radiography KW - Chest KW - Granuloma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39342152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Lung+Cancer+Risk+after+Detection+of+Granulomas+or+Scarring+on+Chest+Radiograph&rft.au=Yu%2C+Ying-Ying%3BCaporaso%2C+Neil+E%3BPinsky%2C+Paul+F%3BChatterjee%2C+Nilanjan%3BEngels%2C+Eric+A&rft.aulast=Yu&rft.aufirst=Ying-Ying&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Smoothened Peptides Inhibit Prostate and Gastric Cancer Cells by Targeting the Hedgehog Pathway: A Potential Cancer Stem Cell Therapy T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39341306; 4589153 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Lou, Hong AU - Tarasova, Nadya AU - Monks, Anne AU - Hose, Curtis AU - Dean, Michael Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Gastric cancer KW - Stem cells KW - Prostate KW - Therapy KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39341306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Smoothened+Peptides+Inhibit+Prostate+and+Gastric+Cancer+Cells+by+Targeting+the+Hedgehog+Pathway%3A+A+Potential+Cancer+Stem+Cell+Therapy&rft.au=Lou%2C+Hong%3BTarasova%2C+Nadya%3BMonks%2C+Anne%3BHose%2C+Curtis%3BDean%2C+Michael&rft.aulast=Lou&rft.aufirst=Hong&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Environment and Genetics in Lung Cancer Etiology (EAGLE): A Novel Population-Based Case-Control Study of Lung Cancer. T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39341242; 4588057 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Rotunno, Melissa AU - Pesatori, Angela AU - Bergen, Andrew AU - Tucker, Peggy AU - Wacholder, Sholom AU - Goldstein, Alisa AU - Lubin, Jay AU - Goldin, Lynn AU - Alavanja, Michael AU - Subar, Amy F AU - Morgan, Glen AU - Consonni, Dario AU - Bertazzi, PierAlberto AU - Caporaso, Neil AU - Landi, Maria Teresa Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Lung cancer KW - Genetics KW - Etiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39341242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Environment+and+Genetics+in+Lung+Cancer+Etiology+%28EAGLE%29%3A+A+Novel+Population-Based+Case-Control+Study+of+Lung+Cancer.&rft.au=Rotunno%2C+Melissa%3BPesatori%2C+Angela%3BBergen%2C+Andrew%3BTucker%2C+Peggy%3BWacholder%2C+Sholom%3BGoldstein%2C+Alisa%3BLubin%2C+Jay%3BGoldin%2C+Lynn%3BAlavanja%2C+Michael%3BSubar%2C+Amy+F%3BMorgan%2C+Glen%3BConsonni%2C+Dario%3BBertazzi%2C+PierAlberto%3BCaporaso%2C+Neil%3BLandi%2C+Maria+Teresa&rft.aulast=Rotunno&rft.aufirst=Melissa&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Plumbagin, a Naturally Occurring Napthoquinone, is a Specific Inhibitor of the Multidrug Resistance-Linked ABC Drug Transporter, ABCG2 T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39341009; 4592211 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Shukla, Suneet AU - Ambudkar, Suresh V Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Drugs KW - Plumbagin KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39341009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Plumbagin%2C+a+Naturally+Occurring+Napthoquinone%2C+is+a+Specific+Inhibitor+of+the+Multidrug+Resistance-Linked+ABC+Drug+Transporter%2C+ABCG2&rft.au=Shukla%2C+Suneet%3BAmbudkar%2C+Suresh+V&rft.aulast=Shukla&rft.aufirst=Suneet&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association between Prostate Cancer Risk and a Locus at Chromosome 8q24 T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39339981; 4591079 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Suuriniemi, Miia AU - Agalliu, Ilir AU - Schaid, Daniel J AU - Johanneson, Bo AU - McDonnell, Shannon K AU - Iwasaki, Lori AU - Stanford, Janet L AU - Ostrander, Elaine A Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Prostate cancer KW - Chromosomes KW - Chromosome 8 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39339981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Association+between+Prostate+Cancer+Risk+and+a+Locus+at+Chromosome+8q24&rft.au=Suuriniemi%2C+Miia%3BAgalliu%2C+Ilir%3BSchaid%2C+Daniel+J%3BJohanneson%2C+Bo%3BMcDonnell%2C+Shannon+K%3BIwasaki%2C+Lori%3BStanford%2C+Janet+L%3BOstrander%2C+Elaine+A&rft.aulast=Suuriniemi&rft.aufirst=Miia&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Array-CGH Characterization of Breast and Liver Tumor Cell Lines with Oposite Metastatic Potential. T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39339978; 4589293 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Ullmannova, Veronika AU - Goodison, Steve AU - Popescu, Nicholas C AU - Zimonjic, Drazen B Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Liver KW - Tumor cell lines KW - Hepatocytes KW - Breast KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39339978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Comparative+Array-CGH+Characterization+of+Breast+and+Liver+Tumor+Cell+Lines+with+Oposite+Metastatic+Potential.&rft.au=Ullmannova%2C+Veronika%3BGoodison%2C+Steve%3BPopescu%2C+Nicholas+C%3BZimonjic%2C+Drazen+B&rft.aulast=Ullmannova&rft.aufirst=Veronika&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural Analogs of Smoothened Intracellular Loops as Potent Inhibitors of Cancer Cell Growth T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39339864; 4593362 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Remsberg, Jarrett R AU - Tarasov, Sergey G AU - Tarasova, Nadya I Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Cancer KW - Analogs KW - Inhibitors KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39339864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Structural+Analogs+of+Smoothened+Intracellular+Loops+as+Potent+Inhibitors+of+Cancer+Cell+Growth&rft.au=Remsberg%2C+Jarrett+R%3BTarasov%2C+Sergey+G%3BTarasova%2C+Nadya+I&rft.aulast=Remsberg&rft.aufirst=Jarrett&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multiple Gastrointestinal Stromal Cell Tumors (GIST) in an Adult, Non-NF1 Patient T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39338186; 4593513 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Gasparotto, Daniela AU - Rossi, S AU - Marzotto, A AU - Sartor, C AU - Carano, Z AU - Bearzi, C AU - Tos, A. P. Dei AU - Maestro, R Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Tumors KW - Stromal cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39338186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Multiple+Gastrointestinal+Stromal+Cell+Tumors+%28GIST%29+in+an+Adult%2C+Non-NF1+Patient&rft.au=Gasparotto%2C+Daniela%3BRossi%2C+S%3BMarzotto%2C+A%3BSartor%2C+C%3BCarano%2C+Z%3BBearzi%2C+C%3BTos%2C+A.+P.+Dei%3BMaestro%2C+R&rft.aulast=Gasparotto&rft.aufirst=Daniela&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Importance of Dose Scheduling of Denileukin Diftitox/Vaccine Combination Therapy to Reduce T Regs and to Enhance Immune Responses T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39337830; 4588270 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Litzinger, Mary AU - Fernando, Romaine AU - Curiel, Tyler AU - Schlom, Jeffrey AU - Palena, Claudia Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Vaccines KW - Therapy KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39337830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Importance+of+Dose+Scheduling+of+Denileukin+Diftitox%2FVaccine+Combination+Therapy+to+Reduce+T+Regs+and+to+Enhance+Immune+Responses&rft.au=Litzinger%2C+Mary%3BFernando%2C+Romaine%3BCuriel%2C+Tyler%3BSchlom%2C+Jeffrey%3BPalena%2C+Claudia&rft.aulast=Litzinger&rft.aufirst=Mary&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Search for Human Correlates in Tumors from Genetically Engineered Mouse Models T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39336751; 4589823 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Varticovski, Lyuba AU - Hollingshead, Melinda AU - Wright, Mollie H AU - Wu, Xiaolin AU - Cherry, James AU - Munroe, David AU - Robles, Ana I Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Animal models KW - Tumors KW - Genetic engineering KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39336751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Search+for+Human+Correlates+in+Tumors+from+Genetically+Engineered+Mouse+Models&rft.au=Varticovski%2C+Lyuba%3BHollingshead%2C+Melinda%3BWright%2C+Mollie+H%3BWu%2C+Xiaolin%3BCherry%2C+James%3BMunroe%2C+David%3BRobles%2C+Ana+I&rft.aulast=Varticovski&rft.aufirst=Lyuba&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identifying Biomarkers from SELDI-TOF MS Data of Ovarian Cancer T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39335320; 4587921 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Kwon, Deukwoo AU - Tadesse, Mahlet AU - Sha, Naijun AU - Pfeiffer, Ruth M AU - Vannucci, Marina Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Ovarian cancer KW - Bioindicators KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39335320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Identifying+Biomarkers+from+SELDI-TOF+MS+Data+of+Ovarian+Cancer&rft.au=Kwon%2C+Deukwoo%3BTadesse%2C+Mahlet%3BSha%2C+Naijun%3BPfeiffer%2C+Ruth+M%3BVannucci%2C+Marina&rft.aulast=Kwon&rft.aufirst=Deukwoo&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interaction of b4 Integrin with Ezrin: Required for Metastatic Phenotype and Activation of mTOR Signaling in Osteosarcoma T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39335019; 4588407 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Wan, Xiaolin AU - Mendoza, Arnulfo AU - Kalburgi, Sonal AU - Harkavy, Brain AU - Yeung, Choh AU - Khanna, Chand AU - Helman, Lee J Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Signal transduction KW - Ezrin KW - Osteosarcoma KW - Metastases KW - Integrins KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39335019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Interaction+of+b4+Integrin+with+Ezrin%3A+Required+for+Metastatic+Phenotype+and+Activation+of+mTOR+Signaling+in+Osteosarcoma&rft.au=Wan%2C+Xiaolin%3BMendoza%2C+Arnulfo%3BKalburgi%2C+Sonal%3BHarkavy%2C+Brain%3BYeung%2C+Choh%3BKhanna%2C+Chand%3BHelman%2C+Lee+J&rft.aulast=Wan&rft.aufirst=Xiaolin&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Persistent Neuronal DNA Damage after Brain Irradiation as Detected by g-H2AX Expression in Histological Sections T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39334939; 4588536 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Satyamitra, Merriline AU - Tofilon, Philip J AU - Camphausen, Kevin A Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Brain injury KW - Irradiation KW - Radiation KW - DNA damage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39334939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Persistent+Neuronal+DNA+Damage+after+Brain+Irradiation+as+Detected+by+g-H2AX+Expression+in+Histological+Sections&rft.au=Satyamitra%2C+Merriline%3BTofilon%2C+Philip+J%3BCamphausen%2C+Kevin+A&rft.aulast=Satyamitra&rft.aufirst=Merriline&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nm23-H1 Suppresses Breast Cancer Metastasis Through the Coordinate Downregulation of Multiple Receptor Genes T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39333624; 4593338 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Horak, Christine E AU - Lee, Jong Heun AU - Elkahloun, Abdel AU - Boissan, Mathieu AU - Dumont, Sylvie AU - Maga, Tara K AU - Christensen, James G AU - Arnaud-Dabernat, Sandrine AU - Palmieri, Diane AU - Stetler-Stevenson, William G AU - Lacombe, Marie-Lise AU - Meltzer, Paul S AU - Steeg, Patricia S Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Breast cancer KW - Nucleoside-diphosphate kinase KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39333624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Nm23-H1+Suppresses+Breast+Cancer+Metastasis+Through+the+Coordinate+Downregulation+of+Multiple+Receptor+Genes&rft.au=Horak%2C+Christine+E%3BLee%2C+Jong+Heun%3BElkahloun%2C+Abdel%3BBoissan%2C+Mathieu%3BDumont%2C+Sylvie%3BMaga%2C+Tara+K%3BChristensen%2C+James+G%3BArnaud-Dabernat%2C+Sandrine%3BPalmieri%2C+Diane%3BStetler-Stevenson%2C+William+G%3BLacombe%2C+Marie-Lise%3BMeltzer%2C+Paul+S%3BSteeg%2C+Patricia+S&rft.aulast=Horak&rft.aufirst=Christine&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polyp Characteristics, Diet, Lifestyle Factors and High-Risk Colorectal Adenoma Recurrence in the Polyp Prevention Trial T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39333391; 4588881 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Laiyemo, Adeyinka O AU - Murphy, Gwen AU - Sansbury, Leah AU - Wang, Zhuoqiao AU - Albert, Paul AU - Schatzkin, Arthur AU - Lanza, Elaine Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Polyps KW - Prevention KW - Diets KW - Risk groups KW - Colorectal cancer KW - Adenoma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39333391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Polyp+Characteristics%2C+Diet%2C+Lifestyle+Factors+and+High-Risk+Colorectal+Adenoma+Recurrence+in+the+Polyp+Prevention+Trial&rft.au=Laiyemo%2C+Adeyinka+O%3BMurphy%2C+Gwen%3BSansbury%2C+Leah%3BWang%2C+Zhuoqiao%3BAlbert%2C+Paul%3BSchatzkin%2C+Arthur%3BLanza%2C+Elaine&rft.aulast=Laiyemo&rft.aufirst=Adeyinka&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of Phase II Drug Metabolizing Enzymes in Rat Liver by Various Agents: Is there a Coordinate Response? T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39333313; 4592730 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Lubet, Ronald A AU - Yao, Ruisheng AU - Grubbs, Clinton J AU - Wang, Yian AU - You, Ming Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Drugs KW - Enzymes KW - Liver KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39333313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Induction+of+Phase+II+Drug+Metabolizing+Enzymes+in+Rat+Liver+by+Various+Agents%3A+Is+there+a+Coordinate+Response%3F&rft.au=Lubet%2C+Ronald+A%3BYao%2C+Ruisheng%3BGrubbs%2C+Clinton+J%3BWang%2C+Yian%3BYou%2C+Ming&rft.aulast=Lubet&rft.aufirst=Ronald&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Genomic Expression Signature Model for Cervical Carcinogenesis by Molecular Profiling of Microdissected Epithelial and Stromal Cells T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39332876; 4592656 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Pennington, Daniel AU - Gius, David AU - Funk, Margot C AU - Rader, Janet S Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Carcinogenesis KW - Cervix KW - Stromal cells KW - Molecular modelling KW - Genomics KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39332876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=A+Genomic+Expression+Signature+Model+for+Cervical+Carcinogenesis+by+Molecular+Profiling+of+Microdissected+Epithelial+and+Stromal+Cells&rft.au=Pennington%2C+Daniel%3BGius%2C+David%3BFunk%2C+Margot+C%3BRader%2C+Janet+S&rft.aulast=Pennington&rft.aufirst=Daniel&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Classification of Pediatric Tumor Xenografts and Cell Lines using microRNA Profiling T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39332821; 4592643 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Wei, Jun S AU - Durinck, Steffen AU - Song, Young AU - Cheuk, Adam Tai Chi AU - Tsang, Patricia AU - Smith, Malcolm A AU - Houghton, Peter AU - Khan, Javed Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Xenografts KW - Pediatrics KW - MiRNA KW - Tumor cell lines KW - Tumors KW - Classification KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39332821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Classification+of+Pediatric+Tumor+Xenografts+and+Cell+Lines+using+microRNA+Profiling&rft.au=Wei%2C+Jun+S%3BDurinck%2C+Steffen%3BSong%2C+Young%3BCheuk%2C+Adam+Tai+Chi%3BTsang%2C+Patricia%3BSmith%2C+Malcolm+A%3BHoughton%2C+Peter%3BKhan%2C+Javed&rft.aulast=Wei&rft.aufirst=Jun&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sequential Treatment with Gemcitabine May Enhance the Immunotherapy of Pancreatic Cancer. T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39332563; 4592389 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Hance, Kenneth W AU - Zaharoff, David A AU - Rogers, Connie J AU - Schlom, Jeffrey AU - Greiner, John W Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Pancreatic cancer KW - Immunotherapy KW - Gemcitabine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39332563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Sequential+Treatment+with+Gemcitabine+May+Enhance+the+Immunotherapy+of+Pancreatic+Cancer.&rft.au=Hance%2C+Kenneth+W%3BZaharoff%2C+David+A%3BRogers%2C+Connie+J%3BSchlom%2C+Jeffrey%3BGreiner%2C+John+W&rft.aulast=Hance&rft.aufirst=Kenneth&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Pregnane X Receptor in the Resistance to All-Trans Retinoic Acid T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39331542; 4592265 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Wang, Ting AU - Ma, Xiaochao AU - Krausz, Kristopher W AU - Idle, Jeffrey R AU - Gonzalez, Frank J Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Retinoic acid KW - Pregnane X receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39331542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Role+of+Pregnane+X+Receptor+in+the+Resistance+to+All-Trans+Retinoic+Acid&rft.au=Wang%2C+Ting%3BMa%2C+Xiaochao%3BKrausz%2C+Kristopher+W%3BIdle%2C+Jeffrey+R%3BGonzalez%2C+Frank+J&rft.aulast=Wang&rft.aufirst=Ting&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ethical Issues in Cancer Chemoprevention Trials: Considerations for IRBs and Investigators T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39331502; 4588804 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Slutsman, Julia AU - Buchanan, David AU - Grady, Christine Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Cancer KW - Chemotherapy KW - Ethics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39331502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Ethical+Issues+in+Cancer+Chemoprevention+Trials%3A+Considerations+for+IRBs+and+Investigators&rft.au=Slutsman%2C+Julia%3BBuchanan%2C+David%3BGrady%2C+Christine&rft.aulast=Slutsman&rft.aufirst=Julia&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Serum Levels of C-peptide and Subsequent Risk of Prostate Cancer in the PLCO Study T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39328667; 4590318 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Hsing, Ann W AU - Sakoda, Lori C AU - Huang, Wen-Yi AU - Chatterjee, Nilanjan AU - Danforth, Kim N AU - Hayes, Richard B Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Prostate cancer KW - Phospholipase C KW - Serum levels KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39328667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Serum+Levels+of+C-peptide+and+Subsequent+Risk+of+Prostate+Cancer+in+the+PLCO+Study&rft.au=Hsing%2C+Ann+W%3BSakoda%2C+Lori+C%3BHuang%2C+Wen-Yi%3BChatterjee%2C+Nilanjan%3BDanforth%2C+Kim+N%3BHayes%2C+Richard+B&rft.aulast=Hsing&rft.aufirst=Ann&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preclinical Studies in Support of the use of Vorinostat (SAHA) for the Treatment of Brain Metastases of Breast Cancer T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39328318; 4588155 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Palmieri, Diane AU - Bronder, Julie L AU - Weil, Robert J AU - Stark, Andreas AU - Davis, Sean AU - Vega-Valle, Eleazar AU - Herring, Jeanne AU - Yoneda, Toshiyuki AU - Kurek, Raffael AU - Mehdorn, H Maximilian AU - Meltzer, Paul S AU - Steeg, Patricia S Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Brain KW - Breast cancer KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39328318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Preclinical+Studies+in+Support+of+the+use+of+Vorinostat+%28SAHA%29+for+the+Treatment+of+Brain+Metastases+of+Breast+Cancer&rft.au=Palmieri%2C+Diane%3BBronder%2C+Julie+L%3BWeil%2C+Robert+J%3BStark%2C+Andreas%3BDavis%2C+Sean%3BVega-Valle%2C+Eleazar%3BHerring%2C+Jeanne%3BYoneda%2C+Toshiyuki%3BKurek%2C+Raffael%3BMehdorn%2C+H+Maximilian%3BMeltzer%2C+Paul+S%3BSteeg%2C+Patricia+S&rft.aulast=Palmieri&rft.aufirst=Diane&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Variant DNA Repair Genes Occur Infrequently in African Americans: Implications for different Clinic Response to Platinum Chemotherapy T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39328214; 4588129 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Gao, Rui AU - Price, Douglas AU - Reed, Eddie AU - Figg, William Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Africa KW - Chemotherapy KW - Platinum KW - Ethnic groups KW - DNA repair KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39328214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Variant+DNA+Repair+Genes+Occur+Infrequently+in+African+Americans%3A+Implications+for+different+Clinic+Response+to+Platinum+Chemotherapy&rft.au=Gao%2C+Rui%3BPrice%2C+Douglas%3BReed%2C+Eddie%3BFigg%2C+William&rft.aulast=Gao&rft.aufirst=Rui&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activation of MAPK and AKT Pathways by BRAF, NRAS and PIK3CA Mutations in Melanoma T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39328168; 4588031 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Libra, Massimo AU - Malaponte, Grazia AU - Ligresti, Giovanni AU - Gangemi, Pietro AU - Siciliano, Roberta AU - Travali, Salvatore AU - Mazzarino, Maria C AU - Mangano, Katia AU - Nicoletti, Ferdinando AU - Wong, Ellis WT AU - Steelman, Linda S AU - McCubrey, James A Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Melanoma KW - Mutation KW - MAP kinase KW - AKT protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39328168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Activation+of+MAPK+and+AKT+Pathways+by+BRAF%2C+NRAS+and+PIK3CA+Mutations+in+Melanoma&rft.au=Libra%2C+Massimo%3BMalaponte%2C+Grazia%3BLigresti%2C+Giovanni%3BGangemi%2C+Pietro%3BSiciliano%2C+Roberta%3BTravali%2C+Salvatore%3BMazzarino%2C+Maria+C%3BMangano%2C+Katia%3BNicoletti%2C+Ferdinando%3BWong%2C+Ellis+WT%3BSteelman%2C+Linda+S%3BMcCubrey%2C+James+A&rft.aulast=Libra&rft.aufirst=Massimo&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - KIR Genes and Risk of Melanoma T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39327924; 4592200 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Landi, Maria Teresa AU - Rotunno, Melissa AU - Martin, Maureen P AU - Single, Richard M AU - Geraghty, Daniel AU - Carrington, Mary Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Melanoma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39327924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=KIR+Genes+and+Risk+of+Melanoma&rft.au=Landi%2C+Maria+Teresa%3BRotunno%2C+Melissa%3BMartin%2C+Maureen+P%3BSingle%2C+Richard+M%3BGeraghty%2C+Daniel%3BCarrington%2C+Mary&rft.aulast=Landi&rft.aufirst=Maria&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tumor Promoting Effects of the PPAR Gamma Agonist Rosiglitazone during the Progression Stages of OH-BBN Induced Urinary Bladder Cancer T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39327258; 4592411 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Lubet, Ronald A AU - Fischer, Susan M AU - Steele, Vernon E AU - Juliana, M Margaret AU - Grubbs, Clinton J Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Cancer KW - Urine KW - Peroxisome proliferator-activated receptors KW - Rosiglitazone KW - Tumors KW - Urinary bladder KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39327258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Tumor+Promoting+Effects+of+the+PPAR+Gamma+Agonist+Rosiglitazone+during+the+Progression+Stages+of+OH-BBN+Induced+Urinary+Bladder+Cancer&rft.au=Lubet%2C+Ronald+A%3BFischer%2C+Susan+M%3BSteele%2C+Vernon+E%3BJuliana%2C+M+Margaret%3BGrubbs%2C+Clinton+J&rft.aulast=Lubet&rft.aufirst=Ronald&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modeling the Tumor Microenvironment In Vitro Using a Bio-mimetic Nanofiber Scaffold T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39326494; 4593025 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Kim, Su Young AU - Li, Wan-Ju AU - Wincovitch, Stephen M AU - Darko, Isaac A AU - Hong, Sung Hyeok AU - Khanna, Chand AU - Tuan, Rocky S AU - Garfield, Susan H AU - Helman, Lee J Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Microenvironments KW - Scaffolds KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39326494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Modeling+the+Tumor+Microenvironment+In+Vitro+Using+a+Bio-mimetic+Nanofiber+Scaffold&rft.au=Kim%2C+Su+Young%3BLi%2C+Wan-Ju%3BWincovitch%2C+Stephen+M%3BDarko%2C+Isaac+A%3BHong%2C+Sung+Hyeok%3BKhanna%2C+Chand%3BTuan%2C+Rocky+S%3BGarfield%2C+Susan+H%3BHelman%2C+Lee+J&rft.aulast=Kim&rft.aufirst=Su&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Profiles in HCT116 and HT29 Cells Exposed to RTA 502 Lead to Insights into the Mechanism of Action T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39326415; 4591145 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Kosakowska-Cholody, Teresa AU - Cholody, W Marek AU - Hariprakasha, Humcha K AU - Meyer, Colin J AU - Michejda, Christopher J Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Lead KW - Gene expression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39326415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Gene+Expression+Profiles+in+HCT116+and+HT29+Cells+Exposed+to+RTA+502+Lead+to+Insights+into+the+Mechanism+of+Action&rft.au=Kosakowska-Cholody%2C+Teresa%3BCholody%2C+W+Marek%3BHariprakasha%2C+Humcha+K%3BMeyer%2C+Colin+J%3BMichejda%2C+Christopher+J&rft.aulast=Kosakowska-Cholody&rft.aufirst=Teresa&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Higher Levels of the Anti-Inflammatory Protein CC10 are Associated with Improvement in Sputum Atypia in Individuals at High Risk for Lung Cancer T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39325113; 4592440 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Chen, Jiping AU - Lam, Stephen AU - Pilon, Aprile AU - McWilliams, Annette AU - MacAulay, Calum AU - Szabo, Eva Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Lung cancer KW - Risk assessment KW - Sputum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39325113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Higher+Levels+of+the+Anti-Inflammatory+Protein+CC10+are+Associated+with+Improvement+in+Sputum+Atypia+in+Individuals+at+High+Risk+for+Lung+Cancer&rft.au=Chen%2C+Jiping%3BLam%2C+Stephen%3BPilon%2C+Aprile%3BMcWilliams%2C+Annette%3BMacAulay%2C+Calum%3BSzabo%2C+Eva&rft.aulast=Chen&rft.aufirst=Jiping&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a Candidate Gene on Chromosome 3P21 Potentially Involved in Early Age Onset Lung Cancer T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39324849; 4587747 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Dracheva, Tatiana V AU - Hong, Keyong AU - Chowdhuri, Sinchita Roy AU - Hames, Megan AU - Player, Audrey AU - Horikawa, Izumi AU - Barrett, Carl AU - Wiest, Jonathan AU - Zhang, Jinghui AU - Clifford, Robert AU - Yang, Ping AU - Sun, Zhifu AU - Aubry, Marie-Christine AU - Jen, Jin Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Lung cancer KW - Chromosomes KW - Chromosome 3 KW - Age KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39324849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Identification+of+a+Candidate+Gene+on+Chromosome+3P21+Potentially+Involved+in+Early+Age+Onset+Lung+Cancer&rft.au=Dracheva%2C+Tatiana+V%3BHong%2C+Keyong%3BChowdhuri%2C+Sinchita+Roy%3BHames%2C+Megan%3BPlayer%2C+Audrey%3BHorikawa%2C+Izumi%3BBarrett%2C+Carl%3BWiest%2C+Jonathan%3BZhang%2C+Jinghui%3BClifford%2C+Robert%3BYang%2C+Ping%3BSun%2C+Zhifu%3BAubry%2C+Marie-Christine%3BJen%2C+Jin&rft.aulast=Dracheva&rft.aufirst=Tatiana&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hormonal Risk Factors for Lung Cancer in Female Lifetime Non-smokers from Shanghai, China T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39324366; 4589584 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Weiss, Jocelyn M AU - Hou, Lifang AU - Shu, Xiao-Ou AU - Ji, Bu-Tian AU - Yang, Gong AU - Li, Honglan AU - Rothman, Nathaniel AU - Blair, Aaron AU - Gao, Yu-Tang AU - Chow, Wong-Ho AU - Zheng, Wei Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - China, People's Rep. KW - China, People's Rep., Shanghai KW - Lung cancer KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39324366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Hormonal+Risk+Factors+for+Lung+Cancer+in+Female+Lifetime+Non-smokers+from+Shanghai%2C+China&rft.au=Weiss%2C+Jocelyn+M%3BHou%2C+Lifang%3BShu%2C+Xiao-Ou%3BJi%2C+Bu-Tian%3BYang%2C+Gong%3BLi%2C+Honglan%3BRothman%2C+Nathaniel%3BBlair%2C+Aaron%3BGao%2C+Yu-Tang%3BChow%2C+Wong-Ho%3BZheng%2C+Wei&rft.aulast=Weiss&rft.aufirst=Jocelyn&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Growth Factors Stimulate Increases in HIF-1a Which Mediate Persistent Increases in VEGF Production in Neuroblastoma Cells Cultured under Hypoxic Conditions T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39322790; 4589171 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Jackson, Jennifer AU - Nakamura, Katsuya AU - Tan, Fei AU - Calvani, Maura AU - Mellilio, Giovanni AU - Thiele, Carol J Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Hypoxia KW - Growth factors KW - Hypoxia-inducible factor 1a KW - Neuroblastoma cells KW - Vascular endothelial growth factor KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39322790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Growth+Factors+Stimulate+Increases+in+HIF-1a+Which+Mediate+Persistent+Increases+in+VEGF+Production+in+Neuroblastoma+Cells+Cultured+under+Hypoxic+Conditions&rft.au=Jackson%2C+Jennifer%3BNakamura%2C+Katsuya%3BTan%2C+Fei%3BCalvani%2C+Maura%3BMellilio%2C+Giovanni%3BThiele%2C+Carol+J&rft.aulast=Jackson&rft.aufirst=Jennifer&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Environmental and Genetic Risk Factors for T(14;18) Subtypes of Diffuse Large B-Cell Lymphoma in a Population-Based, Case-Control Study T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39322712; 4592151 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Morton, Lindsay M AU - Cerhan, James R AU - Hartge, Patricia AU - Dave, Bhavana J AU - Vasef, Mohammad A AU - Weisenburger, Dennis D AU - Jain, Smrati AU - Staudt, Louis M AU - Cozen, Wendy AU - Davis, Scott AU - Severson, Richard K AU - Rothman, Nathaniel AU - Chanock, Stephen J AU - Wang, Sophia S Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Lymphoma KW - B-cell lymphoma KW - Risk factors KW - Environmental factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39322712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Environmental+and+Genetic+Risk+Factors+for+T%2814%3B18%29+Subtypes+of+Diffuse+Large+B-Cell+Lymphoma+in+a+Population-Based%2C+Case-Control+Study&rft.au=Morton%2C+Lindsay+M%3BCerhan%2C+James+R%3BHartge%2C+Patricia%3BDave%2C+Bhavana+J%3BVasef%2C+Mohammad+A%3BWeisenburger%2C+Dennis+D%3BJain%2C+Smrati%3BStaudt%2C+Louis+M%3BCozen%2C+Wendy%3BDavis%2C+Scott%3BSeverson%2C+Richard+K%3BRothman%2C+Nathaniel%3BChanock%2C+Stephen+J%3BWang%2C+Sophia+S&rft.aulast=Morton&rft.aufirst=Lindsay&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Array CGH Analysis of Ovarian Cancer and the Identification of Potential Biomarkers T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39322123; 4592662 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Cherry, James M Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Ovarian cancer KW - Bioindicators KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39322123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Array+CGH+Analysis+of+Ovarian+Cancer+and+the+Identification+of+Potential+Biomarkers&rft.au=Cherry%2C+James+M&rft.aulast=Cherry&rft.aufirst=James&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Variation in AKR1C3 and Bladder Cancer Risk T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39321441; 4591087 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Garcia-Closas, Montserrat AU - Malats, Nuria AU - Real, Francisco AU - Figueroa, Jonine AU - Silverman, Debra AU - Kogevinas, Manolis AU - Welch, Robert AU - Dosemeci, Mustafa AU - Lan, Qing AU - Yeager, Meredith AU - Tardon, Adonina AU - Serra, Consol AU - Carrato, Afredo AU - Garcia-Closas, Reina AU - Castano-Vinyals, Gemma AU - Chanock, Stephen AU - Rothman, Nathaniel Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Cancer KW - Genetic diversity KW - Urinary bladder KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39321441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Combination+Therapy+with+a+Long-Acting+%5Bbeta%5D-Agonist+and+a+Leukotriene+Antagonist+in+Moderate+Asthma&rft.au=Deykin%2C+Aaron%3BWechsler%2C+Michael+E%3BBoushey%2C+Homer+A%3BChinchilli%2C+Vernon+M%3Bet+al&rft.aulast=Deykin&rft.aufirst=Aaron&rft.date=2007-02-01&rft.volume=175&rft.issue=3&rft.spage=228&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of the Role of GATA-3 in ER-positive Breast Cancer Cells by Whole Genome ChIP-Chip T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39320876; 4592968 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Yang, Fan AU - Chen, Yidong AU - Elkahloun, Abdel AU - Long, Lori AU - Davis, Sean AU - Meltzer, Paul Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Breast cancer KW - Genomes KW - GATA-3 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39320876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Identification+of+the+Role+of+GATA-3+in+ER-positive+Breast+Cancer+Cells+by+Whole+Genome+ChIP-Chip&rft.au=Yang%2C+Fan%3BChen%2C+Yidong%3BElkahloun%2C+Abdel%3BLong%2C+Lori%3BDavis%2C+Sean%3BMeltzer%2C+Paul&rft.aulast=Yang&rft.aufirst=Fan&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lysyl Oxidase Genotypes and the Survival of Patients with Prostate Cancer T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39320436; 4589272 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Alchalabi, Tania A AU - Danesi, Romano AU - Dahut, William AU - Price, Douglas K AU - Figg Sr, William Douglas Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Prostate cancer KW - Survival KW - Genotypes KW - Lysyl oxidase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39320436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Lysyl+Oxidase+Genotypes+and+the+Survival+of+Patients+with+Prostate+Cancer&rft.au=Alchalabi%2C+Tania+A%3BDanesi%2C+Romano%3BDahut%2C+William%3BPrice%2C+Douglas+K%3BFigg+Sr%2C+William+Douglas&rft.aulast=Alchalabi&rft.aufirst=Tania&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pathway Analysis of Expression Profiles in African-American and Caucasian Breast Cancer Patients. T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39318845; 4591054 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Martin, Damali N AU - Boersma, Brenda J AU - Yi, Ming AU - Reimers, Mark AU - Yfantis, Harry G AU - Ambs, Stefan Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Africa KW - Breast cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39318845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Pathway+Analysis+of+Expression+Profiles+in+African-American+and+Caucasian+Breast+Cancer+Patients.&rft.au=Martin%2C+Damali+N%3BBoersma%2C+Brenda+J%3BYi%2C+Ming%3BReimers%2C+Mark%3BYfantis%2C+Harry+G%3BAmbs%2C+Stefan&rft.aulast=Martin&rft.aufirst=Damali&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Parallel Isotope-Coded Affinity Tag (ICAT) Analysis and mRNA Expression Profiling of Neuroblastoma; A Pilot Study T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39315712; 4588392 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Song, Young AU - Yu, Li-Rong AU - Wei, Jun S AU - Chen, Qing-Rong AU - Durrinck, Steffen AU - Conrads, Thomas P AU - Veenstra, Timothy D AU - Khan, Javed Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Affinity KW - Gene expression KW - Neuroblastoma KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39315712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+and+critical+care+medicine&rft.atitle=Lethal+and+edema+toxins+in+the+pathogenesis+of+Bacillus+anthracis+septic+shock%3A+implications+for+therapy.&rft.au=Sherer%2C+Kevin%3BLi%2C+Yan%3BCui%2C+Xizhong%3BEichacker%2C+Peter+Q&rft.aulast=Sherer&rft.aufirst=Kevin&rft.date=2007-02-01&rft.volume=175&rft.issue=3&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+and+critical+care+medicine&rft.issn=1073449X&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lymphoblasts of Women with BRCA1 Mutations are Deficient in Cellular Repair of 8,5'-Cyclopurine-2'-Deoxynucleosides and 8-Hydroxy-2'-Deoxyguanosine T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39315469; 4589346 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Rodriguez, Henry AU - Jaruga, Pawel AU - Leber, Dennis AU - Kirkali, Guldal AU - Nyaga, Simon G AU - Evans, Michele K AU - Dizdaroglu, Miral Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Mutation KW - Lymphoblasts KW - BRCA1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39315469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Lymphoblasts+of+Women+with+BRCA1+Mutations+are+Deficient+in+Cellular+Repair+of+8%2C5%27-Cyclopurine-2%27-Deoxynucleosides+and+8-Hydroxy-2%27-Deoxyguanosine&rft.au=Rodriguez%2C+Henry%3BJaruga%2C+Pawel%3BLeber%2C+Dennis%3BKirkali%2C+Guldal%3BNyaga%2C+Simon+G%3BEvans%2C+Michele+K%3BDizdaroglu%2C+Miral&rft.aulast=Rodriguez&rft.aufirst=Henry&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - miR-34a is a Potential Tumor Suppressor Gene on 1p36 in Neuroblastoma T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39313827; 4593428 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Wei, Jun S AU - Cheuk, Adam Tai Chi AU - Song, Young AU - Chen, Qingrong AU - Durinck, Steffen AU - Yu, Li-Rong AU - Veenstra, Timothy AU - Khan, Javed Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Chromosome 1 KW - Tumor suppressor genes KW - Neuroblastoma KW - Tumors KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39313827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=miR-34a+is+a+Potential+Tumor+Suppressor+Gene+on+1p36+in+Neuroblastoma&rft.au=Wei%2C+Jun+S%3BCheuk%2C+Adam+Tai+Chi%3BSong%2C+Young%3BChen%2C+Qingrong%3BDurinck%2C+Steffen%3BYu%2C+Li-Rong%3BVeenstra%2C+Timothy%3BKhan%2C+Javed&rft.aulast=Wei&rft.aufirst=Jun&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel NSAIDs Inhibit the Growth of Non-small Cell Lung Cancer Cells T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39313170; 4590778 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Moody, Terry W AU - Switzer, Christopher AU - Ridnour, Lisa AU - Espey, Michael AU - Berna, Marc AU - Jensen, Robert T AU - Del Soldato, Piero AU - Wink, David Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Lung cancer KW - Non-small cell lung carcinoma KW - Nonsteroidal antiinflammatory drugs KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39313170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Novel+NSAIDs+Inhibit+the+Growth+of+Non-small+Cell+Lung+Cancer+Cells&rft.au=Moody%2C+Terry+W%3BSwitzer%2C+Christopher%3BRidnour%2C+Lisa%3BEspey%2C+Michael%3BBerna%2C+Marc%3BJensen%2C+Robert+T%3BDel+Soldato%2C+Piero%3BWink%2C+David&rft.aulast=Moody&rft.aufirst=Terry&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Epigenetic Regulation of the Metastatic Regulator Ezrin in Rhabdomyosarcoma T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39313111; 4588473 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Yu, Yanlin AU - Merlino, Glenn Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Rhabdomyosarcoma KW - Ezrin KW - Epigenetics KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39313111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Epigenetic+Regulation+of+the+Metastatic+Regulator+Ezrin+in+Rhabdomyosarcoma&rft.au=Yu%2C+Yanlin%3BMerlino%2C+Glenn&rft.aulast=Yu&rft.aufirst=Yanlin&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Cripto-1 is Upregulated by Hypoxia through Hypoxia-Inducible Factor-1 a -Dependent Mechanism T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39312196; 4589176 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Akukwe, Bernadine AU - Strizzi, Luigi AU - Gonzales, Monica AU - Mancino, Mario AU - Watanabe, Kazuhide AU - Hamada, Shin AU - Salomon, David S AU - Bianco, Caterina Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Hypoxia KW - Hypoxia-inducible factor 1a KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39312196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Human+Cripto-1+is+Upregulated+by+Hypoxia+through+Hypoxia-Inducible+Factor-1+a+-Dependent+Mechanism&rft.au=Akukwe%2C+Bernadine%3BStrizzi%2C+Luigi%3BGonzales%2C+Monica%3BMancino%2C+Mario%3BWatanabe%2C+Kazuhide%3BHamada%2C+Shin%3BSalomon%2C+David+S%3BBianco%2C+Caterina&rft.aulast=Akukwe&rft.aufirst=Bernadine&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIF-1a Stabilization by the Redox-Active Metal Ions T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39311387; 4588742 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Kaczmarek, Monika Z AU - Kasprzak, Kazimierz S AU - Salnikow, Konstantin Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Metal ions KW - Hypoxia-inducible factor 1a KW - Metals KW - Stabilizing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39311387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=HIF-1a+Stabilization+by+the+Redox-Active+Metal+Ions&rft.au=Kaczmarek%2C+Monika+Z%3BKasprzak%2C+Kazimierz+S%3BSalnikow%2C+Konstantin&rft.aulast=Kaczmarek&rft.aufirst=Monika&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - U.S. and France Fruit and Vegetable Consumption Patterns T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39311380; 4593490 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Tamers, Sara AU - Agurs-Collins, Tanya AU - Dodd, Kevin AU - Nebeling, Linda Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - France KW - USA KW - Fruits KW - Vegetables KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39311380?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=U.S.+and+France+Fruit+and+Vegetable+Consumption+Patterns&rft.au=Tamers%2C+Sara%3BAgurs-Collins%2C+Tanya%3BDodd%2C+Kevin%3BNebeling%2C+Linda&rft.aulast=Tamers&rft.aufirst=Sara&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Systematic Evaluation of the Inflammation Pathway Identifies Interleukin 1 Gene Variants Associated with Lung Cancer Risk T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39310764; 4593158 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Engels, Eric A AU - Wu, Xifeng AU - Gu, Jian AU - Dong, Qiong AU - Liu, Jun AU - Spitz, Margaret R Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Lung cancer KW - Interleukin 1 KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39310764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Systematic+Evaluation+of+the+Inflammation+Pathway+Identifies+Interleukin+1+Gene+Variants+Associated+with+Lung+Cancer+Risk&rft.au=Engels%2C+Eric+A%3BWu%2C+Xifeng%3BGu%2C+Jian%3BDong%2C+Qiong%3BLiu%2C+Jun%3BSpitz%2C+Margaret+R&rft.aulast=Engels&rft.aufirst=Eric&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - XIAP Associated Factor 1 (XAF1) mRNA Expression in Bladder Cancer Patients Predicts Clinical Response to Neoadjuvant Chemotherapy T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39310680; 4589995 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Pinho, Marcos B AU - Costas, Fernanda AU - Sellos, Joao AU - Diengsmann, Rodrigo AU - Small, Isabele A AU - Guimaraes, Denise P AU - Santos, Valdelice O AU - Andrade, Patricia B AU - Ferreira, Carlos G Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Cancer KW - Chemotherapy KW - Gene expression KW - XIAP protein KW - Urinary bladder KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39310680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=XIAP+Associated+Factor+1+%28XAF1%29+mRNA+Expression+in+Bladder+Cancer+Patients+Predicts+Clinical+Response+to+Neoadjuvant+Chemotherapy&rft.au=Pinho%2C+Marcos+B%3BCostas%2C+Fernanda%3BSellos%2C+Joao%3BDiengsmann%2C+Rodrigo%3BSmall%2C+Isabele+A%3BGuimaraes%2C+Denise+P%3BSantos%2C+Valdelice+O%3BAndrade%2C+Patricia+B%3BFerreira%2C+Carlos+G&rft.aulast=Pinho&rft.aufirst=Marcos&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Validation of Prognostic Markers for Neuroblastoma: A Cross-Platform Analysis T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39306805; 4592696 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Chen, Qing-Rong AU - Song, Young K AU - Wei, Jun S AU - Bilke, Sven AU - Khan, Javed Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Neuroblastoma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39306805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Validation+of+Prognostic+Markers+for+Neuroblastoma%3A+A+Cross-Platform+Analysis&rft.au=Chen%2C+Qing-Rong%3BSong%2C+Young+K%3BWei%2C+Jun+S%3BBilke%2C+Sven%3BKhan%2C+Javed&rft.aulast=Chen&rft.aufirst=Qing-Rong&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tumor Therapy Combining the Proteasome Inhibitor Bortezomib with TRAIL Death Receptor Agonists T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39306079; 4592329 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Sayers, Thomas J AU - Brooks, Alan D AU - Smyth, Mark J AU - Takeda, Kazuyoshi AU - Yagita, Hideo AU - Murphy, William J AU - Shanker, Anil Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Mortality KW - TRAIL protein KW - Proteasome inhibitors KW - Tumors KW - Death receptors KW - Therapy KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39306079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Tumor+Therapy+Combining+the+Proteasome+Inhibitor+Bortezomib+with+TRAIL+Death+Receptor+Agonists&rft.au=Sayers%2C+Thomas+J%3BBrooks%2C+Alan+D%3BSmyth%2C+Mark+J%3BTakeda%2C+Kazuyoshi%3BYagita%2C+Hideo%3BMurphy%2C+William+J%3BShanker%2C+Anil&rft.aulast=Sayers&rft.aufirst=Thomas&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a Quantitative Immunoassay for Measurement of Topoisomerase I Covalent Complex as a Pharmacodynamic Marker for the Effect of Anti-Cancer Drugs. T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39305760; 4588250 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Pfister, Thomas D AU - Parchment, Ralph E AU - Tomaszewski, Joseph AU - Doroshow, James AU - Kinders, Robert J Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Drug development KW - Immunoassays KW - DNA topoisomerase KW - Pharmacodynamics KW - Pharmacology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39305760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Development+of+a+Quantitative+Immunoassay+for+Measurement+of+Topoisomerase+I+Covalent+Complex+as+a+Pharmacodynamic+Marker+for+the+Effect+of+Anti-Cancer+Drugs.&rft.au=Pfister%2C+Thomas+D%3BParchment%2C+Ralph+E%3BTomaszewski%2C+Joseph%3BDoroshow%2C+James%3BKinders%2C+Robert+J&rft.aulast=Pfister&rft.aufirst=Thomas&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Therapeutic Targeting of COP1, a Negative Regulator of p53 and c-Jun, in Hepatocellular Carcinoma T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39302557; 4588203 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Lee, Yun-Han AU - Takami, Taro AU - Heo, Jeonghoon AU - Ton, Anita AU - Conner, Elizabeth AU - Lee, Ju-Seog AU - Factor, Valentina AU - Thorgeirsson, Snorri S Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - C-Jun protein KW - Hepatocellular carcinoma KW - P53 protein KW - Transcription factors KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39302557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Therapeutic+Targeting+of+COP1%2C+a+Negative+Regulator+of+p53+and+c-Jun%2C+in+Hepatocellular+Carcinoma&rft.au=Lee%2C+Yun-Han%3BTakami%2C+Taro%3BHeo%2C+Jeonghoon%3BTon%2C+Anita%3BConner%2C+Elizabeth%3BLee%2C+Ju-Seog%3BFactor%2C+Valentina%3BThorgeirsson%2C+Snorri+S&rft.aulast=Lee&rft.aufirst=Yun-Han&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=1523-6838&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Batracylin, 8-Aminoisoindolo [1,2-b]Quinazolin-10(12H)-One, a Dual Inhibitor of Topoisomerases I and II in Early Clinical Trials: Molecular Mechanism and Biomarkers of Action. T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39302504; 4588188 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Rao, V Ashutosh AU - Agama, Keli AU - Holbeck, Susan AU - Collins, Jerry AU - Pommier, Yves Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Bioindicators KW - Clinical trials KW - DNA topoisomerase KW - Molecular modelling KW - Biomarkers KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39302504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Batracylin%2C+8-Aminoisoindolo+%5B1%2C2-b%5DQuinazolin-10%2812H%29-One%2C+a+Dual+Inhibitor+of+Topoisomerases+I+and+II+in+Early+Clinical+Trials%3A+Molecular+Mechanism+and+Biomarkers+of+Action.&rft.au=Rao%2C+V+Ashutosh%3BAgama%2C+Keli%3BHolbeck%2C+Susan%3BCollins%2C+Jerry%3BPommier%2C+Yves&rft.aulast=Rao&rft.aufirst=V&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sexually Transmitted Infections and Prostate Cancer Risk T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39301686; 4592188 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Huang, Wen-Yi AU - Hayes, Richard B AU - Viscidi, Raphael AU - Lee, Francis AU - Wang, Wayne AU - Whitby, Denise AU - Papp, John R AU - Rabkin, Charles Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Prostate cancer KW - Infectious diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39301686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Sexually+Transmitted+Infections+and+Prostate+Cancer+Risk&rft.au=Huang%2C+Wen-Yi%3BHayes%2C+Richard+B%3BViscidi%2C+Raphael%3BLee%2C+Francis%3BWang%2C+Wayne%3BWhitby%2C+Denise%3BPapp%2C+John+R%3BRabkin%2C+Charles&rft.aulast=Huang&rft.aufirst=Wen-Yi&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association of Epstein-Barr Virus Antibody Levels with Precancerous Gastric Lesions in a High Risk Cohort T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39301646; 4592186 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Rabkin, Charles S AU - You, Wei-cheng AU - Lennette, Evelyne T AU - Gail, Mitchell T AU - Schetter, Aaron J Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Lesions KW - Antibodies KW - Risk factors KW - Epstein-Barr virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39301646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Body+Size%2C+Dairy+Consumption%2C+Puberty%2C+and+Risk+of+Testicular+Germ+Cell+Tumors&rft.au=McGlynn%2C+Katherine+A%3BSakoda%2C+Lori+C%3BRubertone%2C+Mark+V%3BSesterhenn%2C+Isabel+A%3BLyu%2C+Christopher%3BGraubard%2C+Barry+I%3BErickson%2C+Ralph+L&rft.aulast=McGlynn&rft.aufirst=Katherine&rft.date=2007-02-01&rft.volume=165&rft.issue=4&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Spontaneous Remission of Acute Myelogenous Leukemia T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39300335; 4591033 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - De Soto III, Joseph A. AU - Deng, Chuxia X Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Acute myeloid leukemia KW - Remission KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39300335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Spontaneous+Remission+of+Acute+Myelogenous+Leukemia&rft.au=De+Soto+III%2C+Joseph+A.%3BDeng%2C+Chuxia+X&rft.aulast=De+Soto+III&rft.aufirst=Joseph&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multi-color Molecular Imaging of Epidermal Growth Factor Receptors on Tumors with Antibody-fluorophore Conjugates T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39298841; 4592063 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Koyama, Yoshinori AU - Barrett, Tristan AU - Hama, Yukihiro AU - Choyke, Peter L AU - Kobayashi, Hisataka Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Growth factors KW - Imaging techniques KW - Tumors KW - Epidermal growth factor receptors KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39298841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Multi-color+Molecular+Imaging+of+Epidermal+Growth+Factor+Receptors+on+Tumors+with+Antibody-fluorophore+Conjugates&rft.au=Koyama%2C+Yoshinori%3BBarrett%2C+Tristan%3BHama%2C+Yukihiro%3BChoyke%2C+Peter+L%3BKobayashi%2C+Hisataka&rft.aulast=Koyama&rft.aufirst=Yoshinori&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tumor Growth Rate Constants Derived from Data Gathered While Patients are on Clinical Trial Correlate Strongly with Patient Survival: A Novel Strategy for Evaluation of Clinical Trial Data T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39298533; 4589562 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Stein, Wilfred D AU - Bates, Susan E AU - Figg, William D AU - Dahut, William AU - Fojo, Tito Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Clinical trials KW - Growth rate KW - Survival KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39298533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Receiver+operating+characteristic+curve+inference+from+a+sample+with+a+limit+of+detection.&rft.au=Perkins%2C+Neil+J%3BSchisterman%2C+Enrique+F%3BVexler%2C+Albert&rft.aulast=Perkins&rft.aufirst=Neil&rft.date=2007-02-01&rft.volume=165&rft.issue=3&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HLA-A2 Negative Phenotype Significantly Correlates with p53 Nuclear Accumulation in HER-2 and Basal Breast Cancer Subtypes T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39295716; 4589765 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Terrenato, Irene AU - Muti, Paola AU - Mottolese, Marcella AU - Di Benedetto, Anna AU - Melucci, Elisa AU - Del Bello, Duilia AU - Ranieri, Alessandra AU - Venturo, Irene AU - Botti, Claudio AU - Natali, Pier Giorgio AU - Nistico, Paola Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Breast cancer KW - Histocompatibility antigen HLA KW - ErbB-2 protein KW - P53 protein KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39295716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=HLA-A2+Negative+Phenotype+Significantly+Correlates+with+p53+Nuclear+Accumulation+in+HER-2+and+Basal+Breast+Cancer+Subtypes&rft.au=Terrenato%2C+Irene%3BMuti%2C+Paola%3BMottolese%2C+Marcella%3BDi+Benedetto%2C+Anna%3BMelucci%2C+Elisa%3BDel+Bello%2C+Duilia%3BRanieri%2C+Alessandra%3BVenturo%2C+Irene%3BBotti%2C+Claudio%3BNatali%2C+Pier+Giorgio%3BNistico%2C+Paola&rft.aulast=Terrenato&rft.aufirst=Irene&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NCI's First Generation Guidelines for Biospecimen Resources T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39293953; 4589088 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Lockhart, Nicole AU - Vaught, Jimmie AU - Schneider, Julie AU - Fore, Ian AU - Moore, Helen AU - Gillespie, John AU - Scott, Elizabeth AU - Barker, Anna AU - Compton, Carolyn Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Guidelines KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39293953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=NCI%27s+First+Generation+Guidelines+for+Biospecimen+Resources&rft.au=Lockhart%2C+Nicole%3BVaught%2C+Jimmie%3BSchneider%2C+Julie%3BFore%2C+Ian%3BMoore%2C+Helen%3BGillespie%2C+John%3BScott%2C+Elizabeth%3BBarker%2C+Anna%3BCompton%2C+Carolyn&rft.aulast=Lockhart&rft.aufirst=Nicole&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - caArray Microarray Database in the Cancer Biomedical Informatics Grid super(TM) (caBIG super(TM)) T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39293609; 4590157 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Heiskanen, Mervi A AU - Bian, Xiaopeng AU - Swan, Don AU - Basu, Anand Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Cancer KW - Informatics KW - Databases KW - Bioinformatics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39293609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=caArray+Microarray+Database+in+the+Cancer+Biomedical+Informatics+Grid+super%28TM%29+%28caBIG+super%28TM%29%29&rft.au=Heiskanen%2C+Mervi+A%3BBian%2C+Xiaopeng%3BSwan%2C+Don%3BBasu%2C+Anand&rft.aulast=Heiskanen&rft.aufirst=Mervi&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Skin Inflammation and Carcinogenesis Enhanced in Tpl2 Knockout Mouse Model T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39293586; 4591360 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Simmons, John K AU - Pandey, Jyotsna AU - Shan, Zhihong AU - Wiest, Jonathan S Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Skin KW - Carcinogenesis KW - Animal models KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39293586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Skin+Inflammation+and+Carcinogenesis+Enhanced+in+Tpl2+Knockout+Mouse+Model&rft.au=Simmons%2C+John+K%3BPandey%2C+Jyotsna%3BShan%2C+Zhihong%3BWiest%2C+Jonathan+S&rft.aulast=Simmons&rft.aufirst=John&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Early Alterations during Hepatic Oncogenesis in c-Myc/Tgfa Transgenic Mice by Transcriptome Analysis T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39293152; 4590610 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Coulouarn, Cedric AU - Factor, Valentina M AU - Kaposi-Novak, Pal AU - Thorgeirsson, Snorri S Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Mice KW - C-Myc protein KW - Liver KW - Transgenic mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39293152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Identification+of+Early+Alterations+during+Hepatic+Oncogenesis+in+c-Myc%2FTgfa+Transgenic+Mice+by+Transcriptome+Analysis&rft.au=Coulouarn%2C+Cedric%3BFactor%2C+Valentina+M%3BKaposi-Novak%2C+Pal%3BThorgeirsson%2C+Snorri+S&rft.aulast=Coulouarn&rft.aufirst=Cedric&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of the Cytotoxic Effect of Recombinant Hexameric FasL Protein (MegaFasL) on Cultured Thoracic Cancers with Emphasis on Malignant Pleural Mesothelioma. T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39293046; 4591422 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Tran, Thai-Lan AU - Alleva, Annette M AU - Dupuis, Marc AU - Rosat, Jean-Pierre AU - Nguyen, Dao M Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Cancer KW - Mesothelioma KW - FasL protein KW - Thorax KW - Cytotoxicity KW - Recombinants KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39293046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Evaluation+of+the+Cytotoxic+Effect+of+Recombinant+Hexameric+FasL+Protein+%28MegaFasL%29+on+Cultured+Thoracic+Cancers+with+Emphasis+on+Malignant+Pleural+Mesothelioma.&rft.au=Tran%2C+Thai-Lan%3BAlleva%2C+Annette+M%3BDupuis%2C+Marc%3BRosat%2C+Jean-Pierre%3BNguyen%2C+Dao+M&rft.aulast=Tran&rft.aufirst=Thai-Lan&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transgenerational Effects of Stress Targeting the 45S rRNA for Genetic and Epigenetic Reprogramming T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39292580; 4592636 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Shiao, Yih-Horng AU - Spurrier, Joshua M AU - McCann, Sean D AU - Wang, Cuiju AU - Crawford, Erik B AU - Patel, Pritesh AU - Ge, Xin AU - Fields, Janet R AU - Choe, Jihee AU - Anderson, Lucy M Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Stress KW - RRNA 45S KW - Epigenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39292580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Transgenerational+Effects+of+Stress+Targeting+the+45S+rRNA+for+Genetic+and+Epigenetic+Reprogramming&rft.au=Shiao%2C+Yih-Horng%3BSpurrier%2C+Joshua+M%3BMcCann%2C+Sean+D%3BWang%2C+Cuiju%3BCrawford%2C+Erik+B%3BPatel%2C+Pritesh%3BGe%2C+Xin%3BFields%2C+Janet+R%3BChoe%2C+Jihee%3BAnderson%2C+Lucy+M&rft.aulast=Shiao&rft.aufirst=Yih-Horng&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synergistic Inhibition of Hypoxia Inducible Factor-1 (HIF-1) by NSC 644221 in Combination with HDAC Inhibitors T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39292275; 4591252 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Creighton-Gutteridge, Mark AU - Trisciuoglio, Daniella AU - Melillo, Giovanni Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Hypoxia KW - Hypoxia-inducible factor 1 KW - Histone deacetylase KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39292275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Synergistic+Inhibition+of+Hypoxia+Inducible+Factor-1+%28HIF-1%29+by+NSC+644221+in+Combination+with+HDAC+Inhibitors&rft.au=Creighton-Gutteridge%2C+Mark%3BTrisciuoglio%2C+Daniella%3BMelillo%2C+Giovanni&rft.aulast=Creighton-Gutteridge&rft.aufirst=Mark&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/10.1016%2Fj.amjcard.2006.08.028 L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bay 43-9006 Induces Autophagy in Colon Cancer Cells Associated with Reduced Sensitivity to Camptothecin T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39292245; 4592577 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Cao, Liang AU - Yu, Yunkai Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Colon cancer KW - Camptothecin KW - Phagocytosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39292245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Bay+43-9006+Induces+Autophagy+in+Colon+Cancer+Cells+Associated+with+Reduced+Sensitivity+to+Camptothecin&rft.au=Cao%2C+Liang%3BYu%2C+Yunkai&rft.aulast=Cao&rft.aufirst=Liang&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activation of AMP-Activated Protein Kinase (AMPK) by the Lipid-Based Akt Inhibitors, Phosphatidylinositol Ether Lipid Analogues (PIAs) T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39292136; 4589018 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Memmott, Regan M AU - Gills, Joell J AU - Dennis, Phillip A Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Ethers KW - Lipids KW - Phosphatidylinositol KW - AKT protein KW - AMP-activated protein kinase KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39292136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Activation+of+AMP-Activated+Protein+Kinase+%28AMPK%29+by+the+Lipid-Based+Akt+Inhibitors%2C+Phosphatidylinositol+Ether+Lipid+Analogues+%28PIAs%29&rft.au=Memmott%2C+Regan+M%3BGills%2C+Joell+J%3BDennis%2C+Phillip+A&rft.aulast=Memmott&rft.aufirst=Regan&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Second Cancers among 104,760 Survivors of Cervical Cancer: Evaluation of Long-term Risk T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39291834; 4590325 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Chaturvedi, Anil K AU - Engels, Eric A AU - Gilbert, Ethel S AU - Chen, Bingshu E AU - Storm, Hans AU - Lynch, Charles F AU - Hall, Per AU - Langmark, Froydis AU - Pukkala, Eero AU - Kaijser, Magnus AU - Andersson, Michael AU - Fossa, Sophie D AU - Joensuu, Heikki AU - Boice Jr, John D AU - Kleinerman, Ruth A AU - Travis, Lois B Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Cervical cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39291834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Second+Cancers+among+104%2C760+Survivors+of+Cervical+Cancer%3A+Evaluation+of+Long-term+Risk&rft.au=Chaturvedi%2C+Anil+K%3BEngels%2C+Eric+A%3BGilbert%2C+Ethel+S%3BChen%2C+Bingshu+E%3BStorm%2C+Hans%3BLynch%2C+Charles+F%3BHall%2C+Per%3BLangmark%2C+Froydis%3BPukkala%2C+Eero%3BKaijser%2C+Magnus%3BAndersson%2C+Michael%3BFossa%2C+Sophie+D%3BJoensuu%2C+Heikki%3BBoice+Jr%2C+John+D%3BKleinerman%2C+Ruth+A%3BTravis%2C+Lois+B&rft.aulast=Chaturvedi&rft.aufirst=Anil&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of NF-kB and Cytotoxicity with Proteasome Inhibitor Bortezomib in Head and Neck Squamous Cell Carcinoma: A Histological and Molecular Analysis T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39291472; 4588991 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Saigal, Kunal AU - Allen, Clint T AU - Nottingham, Liesl K AU - Chen, Zhong AU - Morris, John C AU - Van Waes, Carter Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Cytotoxicity KW - Proteasome inhibitors KW - Squamous cell carcinoma KW - NF-B protein KW - Head and neck cancer KW - Tumors KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39291472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Inhibition+of+NF-kB+and+Cytotoxicity+with+Proteasome+Inhibitor+Bortezomib+in+Head+and+Neck+Squamous+Cell+Carcinoma%3A+A+Histological+and+Molecular+Analysis&rft.au=Saigal%2C+Kunal%3BAllen%2C+Clint+T%3BNottingham%2C+Liesl+K%3BChen%2C+Zhong%3BMorris%2C+John+C%3BVan+Waes%2C+Carter&rft.aulast=Saigal&rft.aufirst=Kunal&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fruit and Vegetable Intake and Head and Neck Cancer in a Large United States Prospective Cohort Study. T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39291397; 4588869 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Freedman, Neal D AU - Park, Yikyung AU - Subar, Amy F AU - Hollenbeck, Albert R AU - Leitzmann, Michael F AU - Schatzkin, Arthur AU - Abnet, Christian C Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - USA KW - Head and neck cancer KW - Fruits KW - Vegetables KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39291397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Fruit+and+Vegetable+Intake+and+Head+and+Neck+Cancer+in+a+Large+United+States+Prospective+Cohort+Study.&rft.au=Freedman%2C+Neal+D%3BPark%2C+Yikyung%3BSubar%2C+Amy+F%3BHollenbeck%2C+Albert+R%3BLeitzmann%2C+Michael+F%3BSchatzkin%2C+Arthur%3BAbnet%2C+Christian+C&rft.aulast=Freedman&rft.aufirst=Neal&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Comparative Oncology Trials Consortium: Evaluation of RGD Targeted Delivery of Phage Expressing TNF-Alpha to Tumor Bearing Dogs T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39291093; 4592475 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Paoloni, Melissa AU - Tandle, Anita AU - Mazcko, Christina AU - LeBlanc, Amy AU - Vail, David AU - Henry, Carolyn AU - Thamm, Douglas AU - Sorenmo, Karin AU - Hanna, Engy AU - Libutti, Steven AU - Khanna, Chand Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Oncology KW - Tumor necrosis factor-a KW - Tumors KW - Phages KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39291093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=The+Comparative+Oncology+Trials+Consortium%3A+Evaluation+of+RGD+Targeted+Delivery+of+Phage+Expressing+TNF-Alpha+to+Tumor+Bearing+Dogs&rft.au=Paoloni%2C+Melissa%3BTandle%2C+Anita%3BMazcko%2C+Christina%3BLeBlanc%2C+Amy%3BVail%2C+David%3BHenry%2C+Carolyn%3BThamm%2C+Douglas%3BSorenmo%2C+Karin%3BHanna%2C+Engy%3BLibutti%2C+Steven%3BKhanna%2C+Chand&rft.aulast=Paoloni&rft.aufirst=Melissa&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Catalytic Cycle of Atp Hydrolysis by Human P-Glycoprotein (Abcb1): Role of Conserved Residues within the H-Loop in the Nucleotide-Binding Domains T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39290504; 4592215 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Kim, In-Wha AU - Sauna, Zuben E AU - Cuenca, Luciann L AU - FitzGerald, Peter C AU - Xia, Di AU - Ambudkar, Suresh V Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Residues KW - Hydrolysis KW - P-Glycoprotein KW - ATP KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39290504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=The+Catalytic+Cycle+of+Atp+Hydrolysis+by+Human+P-Glycoprotein+%28Abcb1%29%3A+Role+of+Conserved+Residues+within+the+H-Loop+in+the+Nucleotide-Binding+Domains&rft.au=Kim%2C+In-Wha%3BSauna%2C+Zuben+E%3BCuenca%2C+Luciann+L%3BFitzGerald%2C+Peter+C%3BXia%2C+Di%3BAmbudkar%2C+Suresh+V&rft.aulast=Kim&rft.aufirst=In-Wha&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polymorphisms in Immunoregulatory Genes, Smoky Coal Exposure and Lung Cancer Risk in Xuanwei, China T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39290321; 4592189 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Lee, Kyoung-Mu AU - Shen, Min AU - Chapman, Robert S AU - Yeager, Meredith AU - Welch, Robert AU - He, Xingzhou AU - Zheng, Tongzhang AU - Hosgood, Dean AU - Yang, Dongyun AU - Berndt, Sonja I AU - Channock, Stephen AU - Lan, Qing Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - China, People's Rep. KW - Coal KW - Lung cancer KW - Gene polymorphism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39290321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Polymorphisms+in+Immunoregulatory+Genes%2C+Smoky+Coal+Exposure+and+Lung+Cancer+Risk+in+Xuanwei%2C+China&rft.au=Lee%2C+Kyoung-Mu%3BShen%2C+Min%3BChapman%2C+Robert+S%3BYeager%2C+Meredith%3BWelch%2C+Robert%3BHe%2C+Xingzhou%3BZheng%2C+Tongzhang%3BHosgood%2C+Dean%3BYang%2C+Dongyun%3BBerndt%2C+Sonja+I%3BChannock%2C+Stephen%3BLan%2C+Qing&rft.aulast=Lee&rft.aufirst=Kyoung-Mu&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Probe for In Vivo Monitoring of HER2 Expression by PET T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39289758; 4592059 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Kramer-Marek, Gabriela AU - Kiesewetter, Dale AU - Lee, Sang Bong AU - Martiniova, Lucia AU - Jagoda, Elaine AU - Capala, Jacek Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Probes KW - ErbB-2 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39289758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Molecular+Probe+for+In+Vivo+Monitoring+of+HER2+Expression+by+PET&rft.au=Kramer-Marek%2C+Gabriela%3BKiesewetter%2C+Dale%3BLee%2C+Sang+Bong%3BMartiniova%2C+Lucia%3BJagoda%2C+Elaine%3BCapala%2C+Jacek&rft.aulast=Kramer-Marek&rft.aufirst=Gabriela&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regions of Genomic Instability are Potential Resources for Studies of miRNA Function As Well As the Discovery of Novel microRNAs T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39286429; 4590834 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Huppi, Konrad AU - Volfovsky, Natalia AU - Wahlberg, Brady AU - Martin, Scott E AU - Jones, Tamara L AU - Owens, James AU - Mackiewicz, Mark AU - Mushinski, J Frederic AU - Stephens, Robert AU - Caplen, Natasha J Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - MiRNA KW - Genomic instability KW - Potential resources KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39286429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Regions+of+Genomic+Instability+are+Potential+Resources+for+Studies+of+miRNA+Function+As+Well+As+the+Discovery+of+Novel+microRNAs&rft.au=Huppi%2C+Konrad%3BVolfovsky%2C+Natalia%3BWahlberg%2C+Brady%3BMartin%2C+Scott+E%3BJones%2C+Tamara+L%3BOwens%2C+James%3BMackiewicz%2C+Mark%3BMushinski%2C+J+Frederic%3BStephens%2C+Robert%3BCaplen%2C+Natasha+J&rft.aulast=Huppi&rft.aufirst=Konrad&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Potential Therapeutic Targets for Precursor T-Cell Leukemia/Lymphoma using Gene Expression Profiling T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39265502; 4588655 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Lin, Ying-wei AU - Aplan, Peter D Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Lymphoma KW - Leukemia KW - Gene expression KW - Lymphocytes T KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39265502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Identification+of+Potential+Therapeutic+Targets+for+Precursor+T-Cell+Leukemia%2FLymphoma+using+Gene+Expression+Profiling&rft.au=Lin%2C+Ying-wei%3BAplan%2C+Peter+D&rft.aulast=Lin&rft.aufirst=Ying-wei&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterizing a Putative Tumor Suppressor Gene, TUSC1, in Human Lung Cancer T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39255341; 4590065 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Shan, Zhihong AU - Bodaghi, Sohrab AU - Pandey, Jyotsna AU - Parker, Tracy AU - Wiest, Jonathan S Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Lung cancer KW - Tumor suppressor genes KW - Tumors KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39255341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Characterizing+a+Putative+Tumor+Suppressor+Gene%2C+TUSC1%2C+in+Human+Lung+Cancer&rft.au=Shan%2C+Zhihong%3BBodaghi%2C+Sohrab%3BPandey%2C+Jyotsna%3BParker%2C+Tracy%3BWiest%2C+Jonathan+S&rft.aulast=Shan&rft.aufirst=Zhihong&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proline Oxidase Plays a Tumor Suppressor Role in Human Cancer T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39255313; 4590062 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Liu, Yongmin AU - Borchert, Gregory AU - Diwan, Bhalchandra AU - Phang, James Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Cancer KW - Proline oxidase KW - Tumor suppressor genes KW - Tumors KW - Proline KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39255313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Proline+Oxidase+Plays+a+Tumor+Suppressor+Role+in+Human+Cancer&rft.au=Liu%2C+Yongmin%3BBorchert%2C+Gregory%3BDiwan%2C+Bhalchandra%3BPhang%2C+James&rft.aulast=Liu&rft.aufirst=Yongmin&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Validated Assay for Gamma-H2AX as a Pharmacodynamic Biomarker of Response to DNA Damage T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39254903; 4590438 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Ji, Jay Jiuping AU - Putvatana, Ravithat AU - Zhang, Yiping AU - Redon, Christophe AU - Sedelnikova, Olga AU - Yang, Sherry AU - Pommier, Yves AU - Bonner, William AU - Kinders, Robert AU - Parchment, Ralph AU - Hollingshead, Melinda AU - Low, Jennifer AU - Murgo, Anthony AU - Tomaszewski, Joseph E AU - Doroshow, James Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Bioindicators KW - DNA damage KW - Biomarkers KW - Pharmacodynamics KW - Pharmacology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39254903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=A+Validated+Assay+for+Gamma-H2AX+as+a+Pharmacodynamic+Biomarker+of+Response+to+DNA+Damage&rft.au=Ji%2C+Jay+Jiuping%3BPutvatana%2C+Ravithat%3BZhang%2C+Yiping%3BRedon%2C+Christophe%3BSedelnikova%2C+Olga%3BYang%2C+Sherry%3BPommier%2C+Yves%3BBonner%2C+William%3BKinders%2C+Robert%3BParchment%2C+Ralph%3BHollingshead%2C+Melinda%3BLow%2C+Jennifer%3BMurgo%2C+Anthony%3BTomaszewski%2C+Joseph+E%3BDoroshow%2C+James&rft.aulast=Ji&rft.aufirst=Jay&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Prognostic Subtypes of Hepatocellular Carcinoma with Features of Progenitor Cells Linked to wnt-b-Catenin Activation T2 - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AN - 39250409; 4589124 JF - 2007 Annual Meeting of the American Association for Cancer Research (AACR 2007) AU - Yamashita, Taro AU - Forgues, Marshonna AU - Wang, Wei AU - Kim, Jin Woo AU - Ye, Qinghai AU - Jia, Huliang AU - Budhu, Anuradha AU - Takafuji, Vivian AU - Zanetti, Krista A AU - Chen, Yidong AU - Qin, Lun-Xiu AU - Tang, Zhao-You AU - Wang, Xin W Y1 - 2007/04/14/ PY - 2007 DA - 2007 Apr 14 KW - Hepatocellular carcinoma KW - Stem cells KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39250409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.atitle=Novel+Prognostic+Subtypes+of+Hepatocellular+Carcinoma+with+Features+of+Progenitor+Cells+Linked+to+wnt-b-Catenin+Activation&rft.au=Yamashita%2C+Taro%3BForgues%2C+Marshonna%3BWang%2C+Wei%3BKim%2C+Jin+Woo%3BYe%2C+Qinghai%3BJia%2C+Huliang%3BBudhu%2C+Anuradha%3BTakafuji%2C+Vivian%3BZanetti%2C+Krista+A%3BChen%2C+Yidong%3BQin%2C+Lun-Xiu%3BTang%2C+Zhao-You%3BWang%2C+Xin+W&rft.aulast=Yamashita&rft.aufirst=Taro&rft.date=2007-04-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BE3F401 9C%2D0A43%2D4514%2D8F66%2DB86DC90CD935%7D&AKey=%7B728BCE9C%2D121B%2D 46B9%2DA8EE%2DDC51FDFC6C15%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Sugar Binding in Lactose Permease: Anomeric State of a Disaccharide Influences Binding Structure AN - 19809082; 8239574 AB - Lactose permease in Escherichia coli (LacY) transports both anomeric states of disaccharides but has greater affinity for alpha -sugars. Molecular dynamics (MD) simulations are used to probe the protein-sugar interactions, binding structures, and global protein motions in response to sugar binding by investigating LacY (the experimental mutant and wild-type) embedded in a fully hydrated lipid bilayer. A total of 12 MD simulations of 20-25 ns each with beta ( alpha )-d-galactopyranosyl-(1,1)- beta -d-galactopyranoside ( beta beta -(Galp) sub(2)) and alpha beta -(Galp) sub(2) result in binding conformational families that depend on the anomeric state of the sugar. Both sugars strongly interact with Glu126 and alpha beta -(Galp) sub(2) has a greater affinity to this residue. Binding conformations are also seen that involve protein residues not observed in the crystal structure, as well as those involved in the proton translocation (Phe118, Asn119, Asn240, His322, Glu325, and Tyr350). Common to nearly all protein-sugar structures, water acts as a hydrogen bond bridge between the disaccharide and protein. The average binding energy is more attractive for alpha beta -(Galp) sub(2) than beta beta -(Galp) sub(2), i.e. -10.7(+/-0.7) and -3.1(+/-1.0) kcal/mol, respectively. Of the 12 helices in LacY, helix-IV is the least stable with beta beta -(Galp) sub(2) binding resulting in larger distortion than alpha beta -(Galp) sub(2). JF - Journal of Molecular Biology AU - Klauda, J B AU - Brooks, B R AD - National Institutes of Health, Bldg 50, 50 South Drive, Bethesda, MD 20892, USA, klauda@helix.nih.gov Y1 - 2007/04/13/ PY - 2007 DA - 2007 Apr 13 SP - 1523 EP - 1534 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 367 IS - 5 SN - 0022-2836, 0022-2836 KW - Microbiology Abstracts B: Bacteriology KW - Sugar KW - Protein transport KW - Lipid bilayers KW - Thermodynamics KW - Hydrogen bonding KW - Protons KW - Escherichia coli KW - Crystal structure KW - Probes KW - Lactose permease KW - Disaccharides KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19809082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Sugar+Binding+in+Lactose+Permease%3A+Anomeric+State+of+a+Disaccharide+Influences+Binding+Structure&rft.au=Klauda%2C+J+B%3BBrooks%2C+B+R&rft.aulast=Klauda&rft.aufirst=J&rft.date=2007-04-13&rft.volume=367&rft.issue=5&rft.spage=1523&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2007.02.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Protein transport; Sugar; Lipid bilayers; Thermodynamics; Protons; Hydrogen bonding; Probes; Crystal structure; Lactose permease; Disaccharides; Escherichia coli DO - http://dx.doi.org/10.1016/j.jmb.2007.02.001 ER - TY - CPAPER T1 - Review of TE/RM Grant Applications by the Center for Scientific Review at NIH T2 - 2007 Keystone Symposia on Tissue Engineering and Development Biology (D4) AN - 40602005; 4548512 JF - 2007 Keystone Symposia on Tissue Engineering and Development Biology (D4) AU - Sipe, Jean D Y1 - 2007/04/12/ PY - 2007 DA - 2007 Apr 12 KW - Reviews KW - Grants KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40602005?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Tissue+Engineering+and+Development+Biology+%28D4%29&rft.atitle=Review+of+TE%2FRM+Grant+Applications+by+the+Center+for+Scientific+Review+at+NIH&rft.au=Sipe%2C+Jean+D&rft.aulast=Sipe&rft.aufirst=Jean&rft.date=2007-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Tissue+Engineering+and+Development+Biology+%28D4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 0&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Areas of Interests of NIDCR TE/RM Program T2 - 2007 Keystone Symposia on Tissue Engineering and Development Biology (D4) AN - 40601963; 4548510 JF - 2007 Keystone Symposia on Tissue Engineering and Development Biology (D4) AU - Lumelsky, Nadya L Y1 - 2007/04/12/ PY - 2007 DA - 2007 Apr 12 KW - Tissue engineering KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40601963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Tissue+Engineering+and+Development+Biology+%28D4%29&rft.atitle=Areas+of+Interests+of+NIDCR+TE%2FRM+Program&rft.au=Lumelsky%2C+Nadya+L&rft.aulast=Lumelsky&rft.aufirst=Nadya&rft.date=2007-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Tissue+Engineering+and+Development+Biology+%28D4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 0&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Areas of Interest in Bioengineering Research Partnerships T2 - 2007 Keystone Symposia on Tissue Engineering and Development Biology (D4) AN - 40601920; 4548508 JF - 2007 Keystone Symposia on Tissue Engineering and Development Biology (D4) AU - Wang, Fei Y1 - 2007/04/12/ PY - 2007 DA - 2007 Apr 12 KW - Biotechnology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40601920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Tissue+Engineering+and+Development+Biology+%28D4%29&rft.atitle=Areas+of+Interest+in+Bioengineering+Research+Partnerships&rft.au=Wang%2C+Fei&rft.aulast=Wang&rft.aufirst=Fei&rft.date=2007-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Tissue+Engineering+and+Development+Biology+%28D4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 0&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tissue Engineering at NINDS: Opportunities and Challenges T2 - 2007 Keystone Symposia on Tissue Engineering and Development Biology (D4) AN - 40600121; 4548509 JF - 2007 Keystone Symposia on Tissue Engineering and Development Biology (D4) AU - Kalehua, Audrey Y1 - 2007/04/12/ PY - 2007 DA - 2007 Apr 12 KW - Tissue engineering KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40600121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Regulatory+T+Cells+%28B3%29&rft.atitle=Impairment+of+Treg-Specific+Foxp3+Expression+by+Virus-Induced+Dysregulation+of+TGF-beta+Signaling&rft.au=Grant%2C+Christian+W&rft.aulast=Grant&rft.aufirst=Christian&rft.date=2007-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Regulatory+T+Cells+%28B3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 0&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Matrix Scaffold and Adult Stem Cell Differentiation T2 - 2007 Keystone Symposia on Tissue Engineering and Development Biology (D4) AN - 40598325; 4548487 JF - 2007 Keystone Symposia on Tissue Engineering and Development Biology (D4) AU - Tuan, Rocky Y1 - 2007/04/12/ PY - 2007 DA - 2007 Apr 12 KW - Stem cells KW - Scaffolds KW - Differentiation KW - Cell differentiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40598325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Tissue+Engineering+and+Development+Biology+%28D4%29&rft.atitle=Matrix+Scaffold+and+Adult+Stem+Cell+Differentiation&rft.au=Tuan%2C+Rocky&rft.aulast=Tuan&rft.aufirst=Rocky&rft.date=2007-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Tissue+Engineering+and+Development+Biology+%28D4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 0&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NIH Mechanisms to Promote Interactions Between Biology and Engineering T2 - 2007 Keystone Symposia on Tissue Engineering and Development Biology (D4) AN - 40594555; 4548511 JF - 2007 Keystone Symposia on Tissue Engineering and Development Biology (D4) AU - Hunziker, Rosemarie D Y1 - 2007/04/12/ PY - 2007 DA - 2007 Apr 12 KW - Tissue engineering KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40594555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Tissue+Engineering+and+Development+Biology+%28D4%29&rft.atitle=NIH+Mechanisms+to+Promote+Interactions+Between+Biology+and+Engineering&rft.au=Hunziker%2C+Rosemarie+D&rft.aulast=Hunziker&rft.aufirst=Rosemarie&rft.date=2007-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Tissue+Engineering+and+Development+Biology+%28D4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 0&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Engineering Tools for Regulation of Biological Responses T2 - 2007 Keystone Symposia on Tissue Engineering and Development Biology (D4) AN - 40594517; 4548504 JF - 2007 Keystone Symposia on Tissue Engineering and Development Biology (D4) AU - Tuan, Rocky Y1 - 2007/04/12/ PY - 2007 DA - 2007 Apr 12 KW - Tissue engineering KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40594517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Tissue+Engineering+and+Development+Biology+%28D4%29&rft.atitle=Engineering+Tools+for+Regulation+of+Biological+Responses&rft.au=Tuan%2C+Rocky&rft.aulast=Tuan&rft.aufirst=Rocky&rft.date=2007-04-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Tissue+Engineering+and+Development+Biology+%28D4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 0&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - LRG47 (Irgm1) Regulates Macrophage and Hematopoietic Responses to Infection T2 - 2007 Keystone Symposia on Macrophage: Homeostasis, Immunoregulation and Disease (D2) AN - 40597762; 4548537 JF - 2007 Keystone Symposia on Macrophage: Homeostasis, Immunoregulation and Disease (D2) AU - Sher, Alan Y1 - 2007/04/11/ PY - 2007 DA - 2007 Apr 11 KW - Infection KW - Hemopoiesis KW - Macrophages KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40597762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Macrophage%3A+Homeostasis%2C+Immunoregulation+and+Disease+%28D2%29&rft.atitle=LRG47+%28Irgm1%29+Regulates+Macrophage+and+Hematopoietic+Responses+to+Infection&rft.au=Sher%2C+Alan&rft.aulast=Sher&rft.aufirst=Alan&rft.date=2007-04-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Regulatory+T+Cells+%28B3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 3&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of DNA Strand/Chromatid Segregation in Mouse Cell Divisions T2 - 2007 Keystone Symposia on Epigenetics: Regulation of Chromatin Structure in Development and Disease (D3) AN - 40594391; 4551449 JF - 2007 Keystone Symposia on Epigenetics: Regulation of Chromatin Structure in Development and Disease (D3) AU - Klar, Amar J S Y1 - 2007/04/11/ PY - 2007 DA - 2007 Apr 11 KW - Chromatids KW - Cell division KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40594391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Epigenetics%3A+Regulation+of+Chromatin+Structure+in+Development+and+Disease+%28D3%29&rft.atitle=Regulation+of+DNA+Strand%2FChromatid+Segregation+in+Mouse+Cell+Divisions&rft.au=Klar%2C+Amar+J+S&rft.aulast=Klar&rft.aufirst=Amar+J&rft.date=2007-04-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Epigenetics%3A+Regulation+of+Chromatin+Structure+in+Development+and+Disease+%28D3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=86 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Heterochromatin: A Versatile Platform of the Genome T2 - 2007 Keystone Symposia on Epigenetics: Regulation of Chromatin Structure in Development and Disease (D3) AN - 40593075; 4551421 JF - 2007 Keystone Symposia on Epigenetics: Regulation of Chromatin Structure in Development and Disease (D3) AU - Grewal, Shiv I S Y1 - 2007/04/11/ PY - 2007 DA - 2007 Apr 11 KW - Genomes KW - Heterochromatin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40593075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Epigenetics%3A+Regulation+of+Chromatin+Structure+in+Development+and+Disease+%28D3%29&rft.atitle=Heterochromatin%3A+A+Versatile+Platform+of+the+Genome&rft.au=Grewal%2C+Shiv+I+S&rft.aulast=Grewal&rft.aufirst=Shiv+I&rft.date=2007-04-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Epigenetics%3A+Regulation+of+Chromatin+Structure+in+Development+and+Disease+%28D3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=86 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proteasome Inhibition Alters HIstone H3 Lysine Methylation Landscape to Modulate Hormone Regulated Gene Expression T2 - 2007 Keystone Symposia on Epigenetics: Regulation of Chromatin Structure in Development and Disease (D3) AN - 40592277; 4551448 JF - 2007 Keystone Symposia on Epigenetics: Regulation of Chromatin Structure in Development and Disease (D3) AU - Kinyamu, Harriet Karimi Y1 - 2007/04/11/ PY - 2007 DA - 2007 Apr 11 KW - Hormones KW - Gene expression KW - Proteasomes KW - Lysine KW - DNA methylation KW - Methylation KW - Landscape KW - Histone H3 KW - Histones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40592277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Epigenetics%3A+Regulation+of+Chromatin+Structure+in+Development+and+Disease+%28D3%29&rft.atitle=Proteasome+Inhibition+Alters+HIstone+H3+Lysine+Methylation+Landscape+to+Modulate+Hormone+Regulated+Gene+Expression&rft.au=Kinyamu%2C+Harriet+Karimi&rft.aulast=Kinyamu&rft.aufirst=Harriet&rft.date=2007-04-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Epigenetics%3A+Regulation+of+Chromatin+Structure+in+Development+and+Disease+%28D3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=86 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of NOS2/ARG-1 Activity during Infection T2 - 2007 Keystone Symposia on Macrophage: Homeostasis, Immunoregulation and Disease (D2) AN - 40583789; 4548571 JF - 2007 Keystone Symposia on Macrophage: Homeostasis, Immunoregulation and Disease (D2) AU - Wynn, Thomas A Y1 - 2007/04/11/ PY - 2007 DA - 2007 Apr 11 KW - Infection KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40583789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Macrophage%3A+Homeostasis%2C+Immunoregulation+and+Disease+%28D2%29&rft.atitle=Regulation+of+NOS2%2FARG-1+Activity+during+Infection&rft.au=Wynn%2C+Thomas+A&rft.aulast=Wynn&rft.aufirst=Thomas&rft.date=2007-04-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Macrophage%3A+Homeostasis%2C+Immunoregulation+and+Disease+%28D2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 3&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Individual patient data meta-analysis of docetaxel administered once every 3 weeks compared with once every week second-line treatment of advanced non-small-cell lung cancer. AN - 70359141; 17416857 AB - Although several randomized trials have been performed comparing weekly docetaxel (wD) with standard docetaxel once every 3 weeks (3wD) as second-line treatment of advanced non-small-cell lung cancer (NSCLC), no single trial had sufficient power to detect clinically relevant differences in survival. We performed a meta-analysis based on individual patient data from all identified randomized trials comparing wD with 3wD as second-line treatment of advanced NSCLC. Baseline characteristics, treatment assigned, and outcome data were collected for each patient. The primary end point was overall survival. All statistical analyses were stratified by trial. Five eligible trials were identified for a total of 865 patients: 433 patients had been assigned to 3wD, and 432 patients had been assigned to wD. Median age was 62 years (range, 26 to 80 years). Performance status was 0 in 23%, 1 in 58%, and 2 in 16% of patients; 91% of the patients had received previous platinum, and 14% had received previous paclitaxel. With 733 deaths recorded (85%), median survival was 27.4 weeks for patients treated with 3wD, and 26.1 weeks for patients treated with wD (P = .24, log-rank test). There was no significant heterogeneity among the five trials. No relevant differential effect was detected in subgroup analyses. Significantly less severe and febrile neutropenia was reported with wD (P < .00001 for both), whereas no significant differences were observed for anemia, thrombocytopenia, and nonhematologic toxicity. wD shows similar efficacy compared with 3wD, and represents an alternative for second-line treatment of advanced NSCLC. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Di Maio, Massimo AU - Perrone, Francesco AU - Chiodini, Paolo AU - Gallo, Ciro AU - Camps, Carlos AU - Schuette, Wolfgang AU - Quoix, Elisabeth AU - Tsai, Chun-Ming AU - Gridelli, Cesare AD - Clinical Trials Unit, National Cancer Institute, Naples, Italy. Y1 - 2007/04/10/ PY - 2007 DA - 2007 Apr 10 SP - 1377 EP - 1382 VL - 25 IS - 11 KW - Antineoplastic Agents KW - 0 KW - Antineoplastic Agents, Phytogenic KW - Taxoids KW - docetaxel KW - 15H5577CQD KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Antineoplastic Agents -- administration & dosage KW - Chi-Square Distribution KW - Humans KW - Aged KW - Cisplatin -- administration & dosage KW - Cisplatin -- therapeutic use KW - Aged, 80 and over KW - Adult KW - Middle Aged KW - Antineoplastic Agents -- therapeutic use KW - Female KW - Male KW - Survival Analysis KW - Antineoplastic Agents, Phytogenic -- therapeutic use KW - Lung Neoplasms -- drug therapy KW - Taxoids -- therapeutic use KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Antineoplastic Agents, Phytogenic -- administration & dosage KW - Taxoids -- administration & dosage KW - Lung Neoplasms -- pathology KW - Carcinoma, Non-Small-Cell Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70359141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Individual+patient+data+meta-analysis+of+docetaxel+administered+once+every+3+weeks+compared+with+once+every+week+second-line+treatment+of+advanced+non-small-cell+lung+cancer.&rft.au=Di+Maio%2C+Massimo%3BPerrone%2C+Francesco%3BChiodini%2C+Paolo%3BGallo%2C+Ciro%3BCamps%2C+Carlos%3BSchuette%2C+Wolfgang%3BQuoix%2C+Elisabeth%3BTsai%2C+Chun-Ming%3BGridelli%2C+Cesare&rft.aulast=Di+Maio&rft.aufirst=Massimo&rft.date=2007-04-10&rft.volume=25&rft.issue=11&rft.spage=1377&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-15 N1 - Date created - 2007-04-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Modeling Synovial Sarcoma: Timing Is Everything AN - 20803664; 7485388 AB - Synovial sarcoma is characterized by the presence of a fusion protein involving SYT and SSX2. In this issue of Cancer Cell, Haldar et al. have genetically engineered a mouse model of this disease. They show that expression of the SYT-SSX2 fusion gene yields a highly penetrant and representative model of human synovial sarcoma, but only if expression occurs in a particular biologic context. The mouse model will be a valuable resource for studying tumor biology but is also a striking example of how important understanding of normal tissue and developmental biology is to our understanding of cancer. JF - Cancer Cell AU - Davis AU - Meltzer, P S AD - Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Bethesda, MD 20892, USA, pmeltzer@mail.nih.gov Y1 - 2007/04/10/ PY - 2007 DA - 2007 Apr 10 SP - 305 EP - 307 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 11 IS - 4 SN - 1535-6108, 1535-6108 KW - Biotechnology and Bioengineering Abstracts KW - Genetic engineering KW - Animal models KW - synovial sarcoma KW - Fusion protein KW - Tumors KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20803664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Cell&rft.atitle=Modeling+Synovial+Sarcoma%3A+Timing+Is+Everything&rft.au=Davis%3BMeltzer%2C+P+S&rft.aulast=Davis&rft.aufirst=&rft.date=2007-04-10&rft.volume=11&rft.issue=4&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=Cancer+Cell&rft.issn=15356108&rft_id=info:doi/10.1016%2Fj.ccr.2007.03.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genetic engineering; synovial sarcoma; Animal models; Tumors; Fusion protein DO - http://dx.doi.org/10.1016/j.ccr.2007.03.016 ER - TY - JOUR T1 - Stoichiometry of the antiviral protein APOBEC3G in HIV-1 virions AN - 19853695; 7429540 AB - A host cytidine deaminase, APOBEC3G (A3G), inhibits replication of human immunodeficiency virus type 1 (HIV-1) by incorporating into virions in the absence of the virally encoded Vif protein ( Delta vif virions), at least in part by causing G-to-A hypermutation. To gain insight into the antiretroviral function of A3G, we determined the quantities of A3G molecules that are incorporated in Delta vif virions. We combined three experimental approaches-reversed-phase high-pressure liquid chromatography (HPLC), scintillation proximity assay (SPA), and quantitative immunoblotting-to determine the molar ratio of A3G to HIV-1 capsid protein in Delta vif virions. Our studies revealed that the amount of the A3G incorporated into Delta vif virions was proportional to the level of its expression in the viral producing cells, and the ratio of the A3G to Gag in the Delta vif virions produced from activated human peripheral blood mononuclear cells (PBMC) was approximately 1:439. Based on previous estimates of the stoichiometry of HIV-1 Gag in virions (1400-5000), we conclude that approximately 7 (+/-4) molecules of A3G are incorporated into Delta vif virions produced from human PBMCs. These results indicate that virion incorporation of only a few molecules of A3G is sufficient to inhibit HIV-1 replication. JF - Virology AU - Xu, H AU - Chertova, E AU - Chen, J AU - Ott, DE AU - Roser, J D AU - Hu, W S AU - Pathak, V K AD - HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute-Frederick, P. O. Box B, Bldg. 535, Rm. 334, Frederick, MD 21702, USA, vpathak@ncifcrf.gov Y1 - 2007/04/10/ PY - 2007 DA - 2007 Apr 10 SP - 247 EP - 256 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 360 IS - 2 SN - 0042-6822, 0042-6822 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Virions KW - High-performance liquid chromatography KW - Peripheral blood mononuclear cells KW - Antiviral agents KW - Replication KW - Scintillation KW - Human immunodeficiency virus 1 KW - Vif protein KW - Cytidine deaminase KW - Gag protein KW - Capsid protein KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19853695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Stoichiometry+of+the+antiviral+protein+APOBEC3G+in+HIV-1+virions&rft.au=Xu%2C+H%3BChertova%2C+E%3BChen%2C+J%3BOtt%2C+DE%3BRoser%2C+J+D%3BHu%2C+W+S%3BPathak%2C+V+K&rft.aulast=Xu&rft.aufirst=H&rft.date=2007-04-10&rft.volume=360&rft.issue=2&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/10.1016%2Fj.virol.2006.10.036 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Virions; Peripheral blood mononuclear cells; Antiviral agents; Replication; Scintillation; Vif protein; Cytidine deaminase; Gag protein; Capsid protein; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1016/j.virol.2006.10.036 ER - TY - JOUR T1 - Nitric oxide-releasing fabrics and other acrylonitrile-based diazeniumdiolates. AN - 70307361; 17343382 JF - Journal of the American Chemical Society AU - DeRosa, Frank AU - Kibbe, Melina R AU - Najjar, Samer F AU - Citro, Michael L AU - Keefer, Larry K AU - Hrabie, Joseph A AD - Chemistry Section, Laboratory of Comparative Carcinogenesis and Basic Research Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702, USA. Y1 - 2007/04/04/ PY - 2007 DA - 2007 Apr 04 SP - 3786 EP - 3787 VL - 129 IS - 13 SN - 0002-7863, 0002-7863 KW - Azo Compounds KW - 0 KW - diazeniumdiolate KW - Nitric Oxide KW - 31C4KY9ESH KW - Acrylonitrile KW - MP1U0D42PE KW - Eosine Yellowish-(YS) KW - TDQ283MPCW KW - Hematoxylin KW - YKM8PY2Z55 KW - Index Medicus KW - Rats KW - Molecular Structure KW - Carotid Arteries KW - Animals KW - Textiles KW - Azo Compounds -- chemistry KW - Nitric Oxide -- chemistry KW - Acrylonitrile -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70307361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Chemical+Society&rft.atitle=Nitric+oxide-releasing+fabrics+and+other+acrylonitrile-based+diazeniumdiolates.&rft.au=DeRosa%2C+Frank%3BKibbe%2C+Melina+R%3BNajjar%2C+Samer+F%3BCitro%2C+Michael+L%3BKeefer%2C+Larry+K%3BHrabie%2C+Joseph+A&rft.aulast=DeRosa&rft.aufirst=Frank&rft.date=2007-04-04&rft.volume=129&rft.issue=13&rft.spage=3786&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Chemical+Society&rft.issn=00027863&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-10 N1 - Date created - 2007-03-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Postmenopausal Hormone Therapy and Risk of Cardiovascular Disease by Age and Years Since Menopause AN - 20730199; 7406417 AB - CONTEXT: The timing of initiation of hormone therapy may influence its effect on cardiovascular disease. OBJECTIVE: To explore whether the effects of hormone therapy on risk of cardiovascular disease vary by age or years since menopause began. Design, Setting, and Participants Secondary analysis of the Women's Health Initiative (WHI) randomized controlled trials of hormone therapy in which 10 739 postmenopausal women who had undergone a hysterectomy were randomized to conjugated equine estrogens (CEE) or placebo and 16 608 postmenopausal women who had not had a hysterectomy were randomized to CEE plus medroxyprogesterone acetate (CEE + MPA) or placebo. Women aged 50 to 79 years were recruited to the study from 40 US clinical centers between September 1993 and October 1998. MAIN OUTCOME MEASURES: Statistical test for trend of the effect of hormone therapy on coronary heart disease (CHD) and stroke across categories of age and years since menopause in the combined trials. RESULTS: In the combined trials, there were 396 cases of CHD and 327 cases of stroke in the hormone therapy group vs 379 cases of CHD and 239 cases of stroke in the placebo group. For women with less than 10 years since menopause began, the hazard ratio (HR) for CHD was 0.76 (95% confidence interval [CI], 0.50-1.16); 10 to 19 years, 1.10 (95% CI, 0.84-1.45); and 20 or more years, 1.28 (95% CI, 1.03-1.58) (P for trend = .02). The estimated absolute excess risk for CHD for women within 10 years of menopause was -6 per 10 000 person-years; for women 10 to 19 years since menopause began, 4 per 10 000 person-years; and for women 20 or more years from menopause onset, 17 per 10 000 person-years. For the age group of 50 to 59 years, the HR for CHD was 0.93 (95% CI, 0.65-1.33) and the absolute excess risk was -2 per 10 000 person-years; 60 to 69 years, 0.98 (95% CI, 0.79-1.21) and -1 per 10 000 person-years; and 70 to 79 years, 1.26 (95% CI, 1.00-1.59) and 19 per 10 000 person-years (P for trend = .16). Hormone therapy increased the risk of stroke (HR, 1.32; 95% CI, 1.12-1.56). Risk did not vary significantly by age or time since menopause. There was a nonsignificant tendency for the effects of hormone therapy on total mortality to be more favorable in younger than older women (HR of 0.70 for 50-59 years; 1.05 for 60-69 years, and 1.14 for 70-79 years; P for trend = .06). CONCLUSIONS: Women who initiated hormone therapy closer to menopause tended to have reduced CHD risk compared with the increase in CHD risk among women more distant from menopause, but this trend test did not meet our criterion for statistical significance. A similar nonsignificant trend was observed for total mortality but the risk of stroke was elevated regardless of years since menopause. These data should be considered in regard to the short-term treatment of menopausal symptoms. Trial Registration clinicaltrials.gov Identifier: NCT00000611 JF - JAMA: Journal of the American Medical Association AU - Rossouw, Jacques E AU - Prentice, Ross L AU - Manson, JoAnn E AU - Wu, LieLing AU - Barad, David AU - Barnabei, Vanessa M AU - Ko, Marcia AU - LaCroix, Andrea Z AU - Margolis, Karen L AU - Stefanick, Marcia L AD - National Heart, Lung, and Blood Institute, Bethesda, Md (Dr Rossouw) Y1 - 2007/04/04/ PY - 2007 DA - 2007 Apr 04 SP - 1465 EP - 1477 PB - American Medical Association, 515 N. State St. Chicago IL 60610 USA VL - 297 IS - 13 SN - 0098-7484, 0098-7484 KW - Risk Abstracts KW - stroke KW - Mortality KW - Age KW - post-menopause KW - secondary analysis KW - menopause KW - Cardiovascular diseases KW - clinical trials KW - Hormones KW - estrogens KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20730199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA%3A+Journal+of+the+American+Medical+Association&rft.atitle=Postmenopausal+Hormone+Therapy+and+Risk+of+Cardiovascular+Disease+by+Age+and+Years+Since+Menopause&rft.au=Rossouw%2C+Jacques+E%3BPrentice%2C+Ross+L%3BManson%2C+JoAnn+E%3BWu%2C+LieLing%3BBarad%2C+David%3BBarnabei%2C+Vanessa+M%3BKo%2C+Marcia%3BLaCroix%2C+Andrea+Z%3BMargolis%2C+Karen+L%3BStefanick%2C+Marcia+L&rft.aulast=Rossouw&rft.aufirst=Jacques&rft.date=2007-04-04&rft.volume=297&rft.issue=13&rft.spage=1465&rft.isbn=&rft.btitle=&rft.title=JAMA%3A+Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Mortality; stroke; Age; post-menopause; secondary analysis; menopause; Cardiovascular diseases; clinical trials; Hormones; estrogens ER - TY - JOUR T1 - An Enzymatically Activated Fluorescence Probe for Targeted Tumor Imaging AN - 20404748; 7918315 AB - 3-Galactosidase is a widely used reporter enzyme, but although several substrates are available for in vitro detection, its application for in vivo optical imaging remains a challenge. To obtain a probe suitable for in vivo use, we modified our previously developed activatable fluorescence probe, TG- beta Gal (J. Am. Chem. Soc. 2005,127, 4888-4894), on the basis of photochemical and photophysical experiments. The new probe, AM-TG- beta Gal, provides a dramatic fluorescence enhancement upon reaction with beta -galactosidase, and further hydrolysis of the ester moiety by ubiquitous intracellular esterases affords a hydrophilic product that is well retained within the cells without loss of fluorescence. We used a mouse tumor model to assess the practical utility of AM-TG- beta Gal, after confirming that tumors in the model could be labeled with an avidin- beta -galactosidase conjugate. This conjugate was administered to the mice in vivo, followed by AM-TG- beta Gal, and subsequent ex vivo fluorescence imaging clearly visualized intraperitoneal tumors as small as 200 Pm. This strategy has potential clinical application, for example, in video-assisted laparoscopic tumor resection. JF - Journal of the American Chemical Society AU - Kamiya, M AU - Kobayashi, H AU - Hama, Y AU - Koyama, Y AU - Bernardo, M AU - Nagano, T AU - Choyke, P L AU - Urano, Y AD - Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, kobayash@mail.nih.gov Y1 - 2007/04/04/ PY - 2007 DA - 2007 Apr 04 SP - 3918 EP - 3929 VL - 129 IS - 13 SN - 1272-7863, 1272-7863 KW - Biotechnology and Bioengineering Abstracts KW - Fluorescence KW - beta -Galactosidase KW - Laparoscopy KW - esterase KW - Animal models KW - Fluorescent indicators KW - Enzymes KW - Tumors KW - Esters KW - imaging KW - Hydrolysis KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20404748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Chemical+Society&rft.atitle=An+Enzymatically+Activated+Fluorescence+Probe+for+Targeted+Tumor+Imaging&rft.au=Kamiya%2C+M%3BKobayashi%2C+H%3BHama%2C+Y%3BKoyama%2C+Y%3BBernardo%2C+M%3BNagano%2C+T%3BChoyke%2C+P+L%3BUrano%2C+Y&rft.aulast=Kamiya&rft.aufirst=M&rft.date=2007-04-04&rft.volume=129&rft.issue=13&rft.spage=3918&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Chemical+Society&rft.issn=12727863&rft_id=info:doi/10.102l%2Fja067710a LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Fluorescence; beta -Galactosidase; Laparoscopy; esterase; Animal models; Enzymes; Fluorescent indicators; Tumors; Esters; Hydrolysis; imaging DO - http://dx.doi.org/10.102l/ja067710a ER - TY - JOUR T1 - Molecular genetics of nicotine dependence and abstinence: whole genome association using 520,000 SNPs. AN - 70401920; 17407593 AB - Classical genetic studies indicate that nicotine dependence is a substantially heritable complex disorder. Genetic vulnerabilities to nicotine dependence largely overlap with genetic vulnerabilities to dependence on other addictive substances. Successful abstinence from nicotine displays substantial heritable components as well. Some of the heritability for the ability to quit smoking appears to overlap with the genetics of nicotine dependence and some does not. We now report genome wide association studies of nicotine dependent individuals who were successful in abstaining from cigarette smoking, nicotine dependent individuals who were not successful in abstaining and ethnically-matched control subjects free from substantial lifetime use of any addictive substance. These data, and their comparison with data that we have previously obtained from comparisons of four other substance dependent vs control samples support two main ideas: 1) Single nucleotide polymorphisms (SNPs) whose allele frequencies distinguish nicotine-dependent from control individuals identify a set of genes that overlaps significantly with the set of genes that contain markers whose allelic frequencies distinguish the four other substance dependent vs control groups (p < 0.018). 2) SNPs whose allelic frequencies distinguish successful vs unsuccessful abstainers cluster in small genomic regions in ways that are highly unlikely to be due to chance (Monte Carlo p < 0.00001). These clustered SNPs nominate candidate genes for successful abstinence from smoking that are implicated in interesting functions: cell adhesion, enzymes, transcriptional regulators, neurotransmitters and receptors and regulation of DNA, RNA and proteins. As these observations are replicated, they will provide an increasingly-strong basis for understanding mechanisms of successful abstinence, for identifying individuals more or less likely to succeed in smoking cessation efforts and for tailoring therapies so that genotypes can help match smokers with the treatments that are most likely to benefit them. JF - BMC genetics AU - Uhl, George R AU - Liu, Qing-Rong AU - Drgon, Tomas AU - Johnson, Catherine AU - Walther, Donna AU - Rose, Jed E AD - Molecular Neurobiology Branch, NIH-IRP, NIDA, Baltimore, Maryland 21224, USA. guhl@intra.nida.nih.gov Y1 - 2007/04/03/ PY - 2007 DA - 2007 Apr 03 SP - 10 VL - 8 KW - Genetic Markers KW - 0 KW - Index Medicus KW - Humans KW - Adult KW - Genetic Predisposition to Disease KW - Male KW - Female KW - Polymorphism, Single Nucleotide KW - Genome, Human KW - Tobacco Use Disorder -- drug therapy KW - Tobacco Use Disorder -- genetics KW - Substance Withdrawal Syndrome -- genetics KW - Smoking Cessation KW - Substance Withdrawal Syndrome -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70401920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Conference+on+Sleep+Disorders+in+Infancy+and+Childhood&rft.atitle=Cardiorespiratory+and+SAO+sub%282%29+Changes+Precede+Apnea+and+Bradycardia+Events+during+Infant+Home+Memory+Monitoring&rft.au=Hunt%2C+C+E%3BCorwin%2C+M+J%3BWeese-Mayer%2C+D+E%3BWard%2C+S.L.D.%3BLister%2C+G%3BNeuman%2C+M+R%3BTinsley%2C+L+R%3BRamanathan%2C+R%3BWillinger%2C+M&rft.aulast=Hunt&rft.aufirst=C&rft.date=2007-01-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Conference+on+Sleep+Disorders+in+Infancy+and+Childhood&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-30 N1 - Date created - 2007-04-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Addict. 1991 Sep;86(9):1119-27 [1932883] BMC Genet. 2003;4 Suppl 1:S103 [14975171] Arch Gen Psychiatry. 1992 Sep;49(9):723-7 [1355337] Biol Psychiatry. 1996 Oct 15;40(8):776-84 [8894071] Development. 1996 Oct;122(10):3163-71 [8898229] Neuroreport. 1998 Aug 3;9(11):2485-8 [9721919] Neuron. 1998 Sep;21(3):463-6 [9768833] Arch Gen Psychiatry. 1998 Nov;55(11):967-72 [9819064] Mol Psychiatry. 1999 Mar;4(2):129-44 [10208445] Am J Med Genet. 1999 Aug 20;88(4):391-7 [10402507] Hum Genomics. 2004 Nov;1(6):421-34 [15606997] Psychol Med. 2004 Oct;34(7):1251-61 [15697051] FASEB J. 2005 Apr;19(6):588-90 [15703273] Mol Psychiatry. 2005 Apr;10(4):384-92 [15452586] J Cardiovasc Pharmacol. 2005 May;45(5):418-30 [15821437] Hum Mol Genet. 2005 May 15;14(10):1315-25 [15800012] Pharmacogenomics J. 2005;5(3):166-72 [15724146] Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11864-9 [16091475] Neuroscience. 2005;135(3):863-8 [16154279] BMC Genomics. 2005;6:138 [16197552] Brain Res Dev Brain Res. 2005 Nov 7;160(1):1-8 [16154207] Eur J Pharmacol. 2005 Dec 5;526(1-3):36-50 [16289451] Nucleic Acids Res. 2006;34(4):e27 [16478714] BMC Med Genet. 2006;7:9 [16472381] Curr Psychiatry Rep. 2006 Apr;8(2):158-64 [16539894] Twin Res Hum Genet. 2006 Feb;9(1):64-72 [16611469] Nucleic Acids Res. 2006;34(7):e55 [16627870] Am J Med Genet B Neuropsychiatr Genet. 2006 Jun 5;141B(4):354-60 [16671072] NeuroRx. 2006 Jul;3(3):295-301 [16815213] Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):844-53 [16894614] Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):918-25 [17099884] Hum Mol Genet. 2007 Jan 1;16(1):36-49 [17135278] Hum Mol Genet. 2007 Jan 1;16(1):24-35 [17158188] Genet Epidemiol. 1999;17 Suppl 1:S139-44 [10597426] J Neurochem. 2000 Apr;74(4):1489-97 [10737605] Am J Med Genet. 2000 Oct 9;96(5):665-70 [11054775] Am J Hum Genet. 2001 Dec;69(6):1290-300 [11704927] Biochemistry (Mosc). 2001 Oct;66(10):1174-86 [11736639] Nat Rev Genet. 2002 Nov;3(11):862-71 [12415316] Addiction. 2003 Jan;98(1):23-31 [12492752] Nicotine Tob Res. 2003 Apr;5(2):245-54 [12745498] J Neurosci. 2003 Jul 9;23(14):6005-12 [12853418] Am J Med Genet A. 2004 Jan 1;124A(1):19-27 [14679582] BMC Genet. 2003;4 Suppl 1:S101 [14975169] BMC Genet. 2003;4 Suppl 1:S102 [14975170] BMC Genet. 2003;4 Suppl 1:S105 [14975173] Am J Med Genet B Neuropsychiatr Genet. 2004 Apr 1;126B(1):23-36 [15048644] Nitric Oxide. 2004 May;10(3):130-40 [15158692] Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 1;128B(1):94-101 [15211640] Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10308-13 [15210937] Anal Biochem. 2004 Oct 1;333(1):72-8 [15351282] Control Clin Trials. 1990 Apr;11(2):116-28 [2161310] Acta Genet Med Gemellol (Roma). 1990;39(1):91-8 [2392895] J Subst Abuse. 1990;2(1):39-50 [2136102] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer. AN - 70335591; 17401425 AB - Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and the major risk factors include chronic infections with the hepatitis B (HBV) or C (HCV) virus, and exposure to dietary aflatoxin B(1) (AFB(1)) or alcohol consumption. Multiple genetic and epigenetic changes are involved in the molecular pathogenesis of HCC, for example, somatic mutations in the p53 tumor suppressor gene (TP53) and the activation of the WNT signal transduction pathway. AFB(1) frequently induces G:C to T:A transversions at the third base in codon 249 of TP53 and cooperates with HBV in causing p53 mutations in HCC. The detection of TP53 mutant DNA in plasma is a biomarker of both AFB(1) exposure and HCC risk. Chronic infection with HBV and HCV viruses, and oxyradical disorders including hemochromatosis, also generate reactive oxygen/nitrogen species that can both damage DNA and mutate cancer-related genes such as TP53. Certain mutant p53 proteins may exhibit a 'gain of oncogenic function'. The p53 biological network is a key responder to this oxidative and nitrosative stress. Depending on the extent of the DNA damage, p53 regulates the transcription of protective antioxidant genes and with extensive DNA damage, transactivates pro-oxidant genes that contribute to apoptosis. The X gene of HBV (HBx) is the most common open reading frame integrated into the host genome in HCC and the integrated HBx is frequently mutated. Mutant HBx proteins still retain their ability to bind to p53, and attenuate DNA repair and p53-mediated apoptosis. In summary, both viruses and chemicals are implicated in the etiology of TP53 mutations during the molecular pathogenesis of HCC. JF - Oncogene AU - Hussain, S P AU - Schwank, J AU - Staib, F AU - Wang, X W AU - Harris, C C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-4258, USA. Y1 - 2007/04/02/ PY - 2007 DA - 2007 Apr 02 SP - 2166 EP - 2176 VL - 26 IS - 15 SN - 0950-9232, 0950-9232 KW - Tumor Suppressor Protein p53 KW - 0 KW - Aflatoxin B1 KW - 9N2N2Y55MH KW - Index Medicus KW - Hepatitis Viruses KW - Humans KW - Incidence KW - Aflatoxin B1 -- toxicity KW - Hepatitis, Chronic -- complications KW - Mutation KW - Mutagenesis KW - Carcinoma, Hepatocellular -- etiology KW - Carcinoma, Hepatocellular -- genetics KW - Liver Neoplasms -- epidemiology KW - Genetic Predisposition to Disease KW - Tumor Suppressor Protein p53 -- genetics KW - Liver Neoplasms -- etiology KW - Carcinoma, Hepatocellular -- epidemiology KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70335591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=TP53+mutations+and+hepatocellular+carcinoma%3A+insights+into+the+etiology+and+pathogenesis+of+liver+cancer.&rft.au=Hussain%2C+S+P%3BSchwank%2C+J%3BStaib%2C+F%3BWang%2C+X+W%3BHarris%2C+C+C&rft.aulast=Hussain&rft.aufirst=S&rft.date=2007-04-02&rft.volume=26&rft.issue=15&rft.spage=2166&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-07 N1 - Date created - 2007-04-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Enzymatic hydrolysis optimization to ethanol production by simultaneous saccharification and fermentation AN - 860389437; 13858533 AB - There is tremendous interest in using agro-industrial wastes, such as cellulignin, as starting materials for the production of fuels and chemicals. Cellulignin are the solids, which result from the acid hydrolysis of the sugarcane bagasse. The objective of this work was to optimize the enzymatic hydrolysis of the cellulose fraction of cellulignin, and to study its fermentation to ethanol using Saccharomyces cerevisiae. Cellulose conversion was optimized using response surface methods with pH, enzyme loading, solid percentage, and temperature as factor variables. The optimum conditions that maximized the conversion of cellulose to glucose, calculated from the initial dried weight of pretreated cellulignin, (43C, 2%, and 24.4 FPU/g of pretreated cellulignin) such as the glucose concentration (47C, 10%, and 25.6 FPU/g of pretreated cellulignin) were found. The desirability function was used to find conditions that optimize both, conversion to glucose and glucose concentration (47C, 10%, and 25.9 FPU/g of pretreated cellulignin). The resulting enzymatic hydrolyzate was fermented yielding a final ethanol concentration of 30.0 g/L, in only 10 h, and reaching a volumetric productivity of 3.0 g/L.h, which is close to the values obtained in the conventional ethanol fermentation of sugar cane juice (5.0-8.0 g/L.h) in Brazil. JF - Applied Biochemistry and Biotechnology AU - Vasquez, Mariana Penuela AU - Silva, Juliana Nascimento C AU - Souza, Mauricio Bezerra AU - Pereira, Nei AD - Centro de Tecnologia--Bloco E, Escola de Quimica--Universidade Federal do Rio de Janeiro, CEP 21.949-900, Rio de Janeiro-RJ, Brasil, nei@eq.ufrj.br Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 141 EP - 153 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 137-140 IS - 1-12 SN - 0273-2289, 0273-2289 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Sugar KW - Fermentation KW - Fuels KW - Cellulose KW - Juices KW - Wastes KW - Glucose KW - Enzymes KW - Hydrolysis KW - Saccharomyces cerevisiae KW - Bagasse KW - pH effects KW - Ethanol KW - A 01380:Plant Protection, Fungicides & Seed Treatments KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/860389437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Biochemistry+and+Biotechnology&rft.atitle=Enzymatic+hydrolysis+optimization+to+ethanol+production+by+simultaneous+saccharification+and+fermentation&rft.au=Vasquez%2C+Mariana+Penuela%3BSilva%2C+Juliana+Nascimento+C%3BSouza%2C+Mauricio+Bezerra%3BPereira%2C+Nei&rft.aulast=Vasquez&rft.aufirst=Mariana&rft.date=2007-04-01&rft.volume=137-140&rft.issue=1-12&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Applied+Biochemistry+and+Biotechnology&rft.issn=02732289&rft_id=info:doi/10.1007%2Fs12010-007-9046-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-04-01 N1 - Last updated - 2013-12-04 N1 - SubjectsTermNotLitGenreText - Temperature effects; Sugar; Fermentation; Fuels; Cellulose; Glucose; Wastes; Juices; Enzymes; Hydrolysis; Bagasse; pH effects; Ethanol; Saccharomyces cerevisiae DO - http://dx.doi.org/10.1007/s12010-007-9046-2 ER - TY - JOUR T1 - Correlation of hearing screening with developmental outcomes in infants over a 2-year period. AN - 85413875; pmid-17453458 AB - Evoked otoacoustic emission (OAE) and auditory brainstem response (ABR) results for hearing screening among infants have good concordance. However, good correlation with the Griffiths Developmental Scales remains to be desired.To correlate hearing screening outcomes of a cohort of infants with developmental outcomes at 6 and 12 months.A cohort of pregnant women was identified in several communities in a rural area (Bulacan province) from April 2002 to February 2003 as part of a population-based study determining maternal exposure to pollutants and infant outcomes, with a total follow-up of 2 years. Pregnant mothers were identified and followed up until delivery at a secondary, provincial hospital. Hearing screening was performed with OAEs and ABR. Mental development of infants was assessed at 6 and 12 months using Griffiths Mental Developmental Scales - locomotor, personal-social, hearing and speech, hand and eye coordination, performance tests.Among the 1086 babies recruited, there were 724 with hearing assessment. Of these 724 babies, 565 had both OAE testing and ABR. Overall in 1130 ears, OAE and ABR testing showed an observed agreement of 99%, agreement due to chance of 96%, and kappa agreement of 79% (p=0.00) in diagnosing bilateral hearing losses. OAEs had a sensitivity of 86.4% (95% CI 64-96.4%) and a specificity of 99.4% (95% CI 98.6-99.7%). At the end of the study, there were 708/724 (97.8%) infants with normal hearing, 7/724 (1.0%) with unilateral hearing loss, 8/724 (1.1%) with bilateral mild hearing loss, and 1/724 (0.1%) with bilateral profound hearing loss, who demonstrated consistent mental delay throughout. Follow-up rates for developmental examinations at 6 and 12 months were 98% and 81.25%, respectively. In these groups, there were 8 (1%) infants at 6 months and 18 (2.4%) at 12 months with developmental delay (Griffiths Mental Developmental Scales). JF - Acta oto-laryngologica AU - Chiong, Charlotte AU - Ostrea, Enrique AU - Reyes, Alexis AU - Llanes, Erasmo Gonzalo AU - Uy, Maria Esterlita AU - Chan, Abner AD - Department of Otorhinolaryngology, College of Medicine - Philippine General Hospital, Philippine National Ear Institute, National Institutes of Health, University of the Philippines, Manila, Philippines. Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 384 EP - 388 VL - 127 IS - 4 SN - 0001-6489, 0001-6489 KW - Index Medicus KW - National Library of Medicine KW - Auditory Threshold KW - Child, Preschool KW - Cohort Studies KW - *Developmental Disabilities: diagnosis KW - *Evoked Potentials, Auditory, Brain Stem KW - Female KW - *Hearing Loss, Bilateral: diagnosis KW - *Hearing Loss, Unilateral: diagnosis KW - *Hearing Tests KW - Humans KW - Infant KW - Infant, Newborn KW - Longitudinal Studies KW - Male KW - *Neonatal Screening KW - *Otoacoustic Emissions, Spontaneous KW - Pregnancy KW - Referral and Consultation KW - Statistics as Topic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85413875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+oto-laryngologica&rft.atitle=Correlation+of+hearing+screening+with+developmental+outcomes+in+infants+over+a+2-year+period.&rft.au=Chiong%2C+Charlotte%3BOstrea%2C+Enrique%3BReyes%2C+Alexis%3BLlanes%2C+Erasmo+Gonzalo%3BUy%2C+Maria+Esterlita%3BChan%2C+Abner&rft.aulast=Chiong&rft.aufirst=Charlotte&rft.date=2007-04-01&rft.volume=127&rft.issue=4&rft.spage=384&rft.isbn=&rft.btitle=&rft.title=Acta+oto-laryngologica&rft.issn=00016489&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Preliminary ultrasound observation of lingual movement patterns during nutritive versus non-nutritive sucking in a premature infant. AN - 85398247; pmid-17294300 AB - Term neonates must suck, swallow, and respire in a coordinated manner during successful oral feeding. When infants are born prematurely, these skills may not be fully mature. To stimulate sucking responses, premature infants are offered pacifiers under the premise that non-nutritive sucking experiences facilitate oral feeding readiness. This case reported examined the lingual-hyoid mechanics of non-nutritive suck (NNS) patterns with a pacifier versus nutritive suck (NS) during a bottle feed in a premature infant using a noninvasive ultrasound imaging technique as a pilot to discern aspects of oral feeding candidacy. Lingual patterns during NS resulted in significantly greater displacements and excursions than NNS (p < 0.0001) in both anterior and posterior regions of the tongue (p < 0.0001). In addition, the angle of hyoid movement during NNS was significantly smaller (p < 0.05) than the angle recorded during NS tasks. Unlike an expected neonatal sucking pattern of horizontal anterior-posterior movements of the tongue body, vertical tongue body excursions occurred as described in the literature of representing a 6-9-month developmental skill level. Through the integration of semiautomatic computerized analyses of tongue surface configurations and hyoid activity, these data may enhance knowledge of oral swallowing function in developing preterm neonates. JF - Dysphagia AU - Miller, Jeri L AU - Kang, Seon M AD - Department of Rehabilitation Medicine, Physical Disabilities Branch, The National Institutes of Health, Bethesda, Maryland 20892-1604, USA. jmiller@cc.nih.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 150 EP - 160 VL - 22 IS - 2 SN - 0179-051X, 0179-051X KW - Index Medicus KW - National Library of Medicine KW - Age Factors KW - *Bottle Feeding KW - *Deglutition: physiology KW - *Deglutition Disorders: ultrasonography KW - Food KW - Humans KW - Infant, Newborn KW - *Infant, Premature: physiology KW - Motor Skills KW - *Pacifiers KW - *Sucking Behavior: physiology KW - Time Factors KW - Tongue: physiology KW - Tongue: ultrasonography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85398247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Image-guided%2C+direct+convective+delivery+of+glucocerebrosidase+for+neuronopathic+Gaucher+disease.&rft.au=Lonser%2C+R+R%3BSchiffman%2C+R%3BRobison%2C+R+A%3BButman%2C+J+A%3BQuezado%2C+Z%3BWalker%2C+M+L%3BMorrison%2C+P+F%3BWalbridge%2C+S%3BMurray%2C+G+J%3BPark%2C+D+M%3BBrady%2C+R+O%3BOldfield%2C+E+H&rft.aulast=Lonser&rft.aufirst=R&rft.date=2007-01-23&rft.volume=68&rft.issue=4&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=1526-632X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Grounding object concepts in perception and action: evidence from fMRI studies of tools. AN - 85396227; pmid-17533768 AB - Studies of categories of objects, including tools, have spurred the development of the sensory-motor model of object concept representation. According to this model, information about objects is represented in the same neural subsystems that are active when we perceive and use them. In turn, this model has provided insight into the brain mechanisms of tool use. For tools, three types of information are especially important for identification: the characteristic motion with which they move (such as the up and down motion of a hammer), their visual form, and the way that they are manipulated. Evidence from neuropsychological, non-human primates, and neuroimaging studies suggest a mapping between specific brain regions and these fundamental identifying properties of tools. We focus on neuroimaging studies of the left posterior middle temporal gyrus. This brain region is active both when subjects perceive moving tools and when they answer questions about tools, and is responsive to the type of visual motion characteristic of tools: rigid, unarticulated motion. We describe a simple model that explains how low-level receptive field properties like those known to exist in area MT/V5 could give rise to the high-level category-related representations observed in functional imaging experiments. JF - Cortex; a journal devoted to the study of the nervous system and behavior AU - Beauchamp, Michael S AU - Martin, Alex AD - Section on Cognitive Neuropsychology, Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, 20892-1366 MD, USA. Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 461 EP - 468 VL - 43 IS - 3 SN - 0010-9452, 0010-9452 KW - Index Medicus KW - National Library of Medicine KW - *Brain Mapping KW - *Comprehension: physiology KW - *Form Perception: physiology KW - Humans KW - Magnetic Resonance Imaging KW - Models, Neurological KW - Motion Perception: physiology KW - *Space Perception: physiology KW - *Temporal Lobe: physiology KW - *Tool Use Behavior: physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85396227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cortex%3B+a+journal+devoted+to+the+study+of+the+nervous+system+and+behavior&rft.atitle=Grounding+object+concepts+in+perception+and+action%3A+evidence+from+fMRI+studies+of+tools.&rft.au=Beauchamp%2C+Michael+S%3BMartin%2C+Alex&rft.aulast=Beauchamp&rft.aufirst=Michael&rft.date=2007-04-01&rft.volume=43&rft.issue=3&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=Cortex%3B+a+journal+devoted+to+the+study+of+the+nervous+system+and+behavior&rft.issn=00109452&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Simple partial volume transceive coils for in vivo 1H MR studies at high magnetic fields AN - 745723397; 13157428 AB - The development of simple radiofrequency (RF) coils for magnetic resonance (MR) of the human brain is still of high interest in the engineering of systems for which phased arrays are not yet available. Particularly, high-field MR studies will benefit from configurations with simple coils that are easy to build and require only a few RF parts for operation (e.g., quadrature hybrids). In this article we describe selected simple transmit/receive (transceive) partial volume coil assemblies for human brain studies at high magnetic fields of 3, 4, and 7 T (130, 170, and 300 MHz). To characterize coil performance, the experimental results of MRI of phantoms, anatomical MRI, and single-voxel MRS of healthy human volunteers are presented. JF - Concepts in Magnetic Resonance B AU - Choi, In-Young AU - Lee, Sang-Pil AU - Garwood, Michael AU - Ugurbil, Kamil AU - Merkle, Hellmut AD - Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS 66160, merkleh@mail.nih.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 71 EP - 85 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 31B IS - 2 SN - 1552-5031, 1552-5031 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Magnetic fields KW - Hybrids KW - Magnetic resonance imaging KW - Brain KW - N.M.R. KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745723397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Concepts+in+Magnetic+Resonance+B&rft.atitle=Simple+partial+volume+transceive+coils+for+in+vivo+1H+MR+studies+at+high+magnetic+fields&rft.au=Choi%2C+In-Young%3BLee%2C+Sang-Pil%3BGarwood%2C+Michael%3BUgurbil%2C+Kamil%3BMerkle%2C+Hellmut&rft.aulast=Choi&rft.aufirst=In-Young&rft.date=2007-04-01&rft.volume=31B&rft.issue=2&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Concepts+in+Magnetic+Resonance+B&rft.issn=15525031&rft_id=info:doi/10.1002%2Fcmr.b.20086 L2 - http://www3.interscience.wiley.com/journal/114207489/abstract LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Magnetic fields; Hybrids; Magnetic resonance imaging; Brain; N.M.R. DO - http://dx.doi.org/10.1002/cmr.b.20086 ER - TY - JOUR T1 - Blocking of conditioning to a cocaine-paired stimulus: testing the hypothesis that cocaine perpetually produces a signal of larger-than-expected reward. AN - 70585897; 17445874 AB - According to a recent account of addiction, dopaminergic effects of drugs like cocaine mimic the neuronal signal that occurs when a natural reward has a larger value than expected. Consequently, the drug's expected reward value increases with each administration, leading to an over-selection of drug-seeking behavior. One prediction of this hypothesis is that the blocking effect, a cornerstone of contemporary learning theory, should not occur with drug reinforcers. To test this prediction, two groups of rats were trained to self-administer cocaine with a nose-poking response. For 5 sessions, a tone was paired with each self-administered injection (blocking group), or no stimulus was paired with injection (non-blocking group). Then, in both groups, the tone and a light were both paired with each injection for 5 sessions. In subsequent testing, the light functioned as a conditioned reinforcer for a new response (lever-pressing) in the non-blocking group, but not the blocking group. Thus, contrary to prediction, pre-training with the tone blocked conditioning to the light. Although these results fail to support a potentially powerful explanation of addiction, they are consistent with the fact that most conditioning and learning phenomena that occur with non-drug reinforcers can also be demonstrated with drug reinforcers. JF - Pharmacology, biochemistry, and behavior AU - Panlilio, Leigh V AU - Thorndike, Eric B AU - Schindler, Charles W AD - Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA. lpanlili@intra.nida.nih.gov Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 774 EP - 777 VL - 86 IS - 4 SN - 0091-3057, 0091-3057 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Self Administration KW - Reinforcement (Psychology) KW - Cocaine-Related Disorders -- psychology KW - Male KW - Models, Psychological KW - Reward KW - Conditioning (Psychology) -- physiology KW - Cocaine -- pharmacology KW - Cocaine -- administration & dosage KW - Conditioning (Psychology) -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70585897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Blocking+of+conditioning+to+a+cocaine-paired+stimulus%3A+testing+the+hypothesis+that+cocaine+perpetually+produces+a+signal+of+larger-than-expected+reward.&rft.au=Panlilio%2C+Leigh+V%3BThorndike%2C+Eric+B%3BSchindler%2C+Charles+W&rft.aulast=Panlilio&rft.aufirst=Leigh&rft.date=2007-04-01&rft.volume=86&rft.issue=4&rft.spage=774&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-20 N1 - Date created - 2007-06-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurophysiol. 2003 Aug;90(2):993-1010 [12904500] Behav Pharmacol. 2003 Jul;14(4):315-22 [12838037] Neuropharmacology. 2004;47 Suppl 1:202-13 [15464138] Biol Psychiatry. 1982 Mar;17(3):351-61 [7082701] Behav Neurosci. 1986 Jun;100(3):315-9 [3730137] Behav Neurosci. 1993 Apr;107(2):235-45 [8484889] J Neurosci. 1996 May 15;16(10):3459-73 [8627379] Psychopharmacology (Berl). 1996 Jun;125(3):202-8 [8815954] Science. 1998 Jan 23;279(5350):570-3 [9438852] J Neurophysiol. 1998 Jul;80(1):1-27 [9658025] J Exp Psychol Anim Behav Process. 1999 Jan;25(1):45-67 [9987858] Neurosci Biobehav Rev. 1999 May;23(5):717-41 [10392662] Science. 2004 Dec 10;306(5703):1944-7 [15591205] Annu Rev Neurosci. 2000;23:473-500 [10845072] Nature. 2001 Jul 5;412(6842):43-8 [11452299] Physiol Behav. 2002 Jul;76(3):353-64 [12117572] Psychopharmacology (Berl). 2003 Apr;167(1):9-19 [12644888] Behav Neurosci. 2003 Jun;117(3):650-6 [12802893] Neuropharmacology. 2004;47 Suppl 1:180-9 [15464136] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Heat shock protein 90: the cancer chaperone. AN - 70555633; 17536171 AB - Heat shock protein 90 (Hsp90) is a molecular chaperone required for the stability and function of a number of conditionally activated and/or expressed signalling proteins, as well as multiple mutated, chimeric, and/or over-expressed signalling proteins, that promote cancer cell growth and/or survival. Hsp90 inhibitors are unique in that, although they are directed towards a specific molecular target, they simultaneously inhibit multiple cellular signalling pathways. By inhibiting nodal points in multiple overlapping survival pathways utilized by cancer cells, combination of an Hsp90 inhibitor with standard chemotherapeutic agents may dramatically increase the in vivo efficacy of the standard agent. Hsp90 inhibitors may circumvent the characteristic genetic plasticity that has allowed cancer cells to eventually evade the toxic effects of most molecularly targeted agents. The mechanism-based use of Hsp90 inhibitors, both alone and in combination with other drugs, should be effective toward multiple forms of cancer. Further, because Hsp90 inhibitors also induce Hsf-1-dependent expression of Hsp70, and because certain mutated Hsp90 client proteins are neurotoxic, these drugs display ameliorative properties in several neurodegenerative disease models, suggesting a novel role for Hsp90 inhibitors in treating multiple pathologies involving neurodegeneration. JF - Journal of biosciences AU - Neckers, Len AD - Urologic Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA. len@helix.nih.gov Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 517 EP - 530 VL - 32 IS - 3 SN - 0250-5991, 0250-5991 KW - Antineoplastic Agents KW - 0 KW - HSP90 Heat-Shock Proteins KW - Index Medicus KW - Animals KW - Humans KW - Neoplasms -- drug therapy KW - HSP90 Heat-Shock Proteins -- metabolism KW - HSP90 Heat-Shock Proteins -- antagonists & inhibitors KW - Antineoplastic Agents -- pharmacology KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70555633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biosciences&rft.atitle=Heat+shock+protein+90%3A+the+cancer+chaperone.&rft.au=Neckers%2C+Len&rft.aulast=Neckers&rft.aufirst=Len&rft.date=2007-04-01&rft.volume=32&rft.issue=3&rft.spage=517&rft.isbn=&rft.btitle=&rft.title=Journal+of+biosciences&rft.issn=02505991&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-05 N1 - Date created - 2007-05-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Carcinogenic food contaminants. AN - 70553430; 17530489 AB - A large number of scientific studies and reviews have addressed the potential for dietary components to influence the risk of developing cancer. One topic of particular interest has been the impact of food contaminants. Two complementary programs, among others, have reviewed and synthesized information on the carcinogenic potential of food contaminants and judged the degree of evidence linking different food contaminants to the risk of cancer in humans. These programs, the International Agency for Research on Cancer's IARC Monographs on the Evaluation of Carcinogenic Risks to Humans and the US National Toxicology Program's Report of Carcinogens have reviewed hundreds of chemicals, mixtures, and natural products and then graded the cancer risk posed to humans. Contaminants with the highest level of evidence include aflatoxin, alcoholic beverages, 2,3,7,8-tetracholordibenzo-p-dioxin. Agents with a moderate level of evidence include acetaldehyde, polycyclic aromatic hydrocarbons, some nitrosamines, and yerba mate. Agents with a low level of evidence include bracken fern, fumonsin B(1), ochratoxin, and others. This review presents a summary of the evidence for the carcinogenicity of these and other agents and the ranks provided by two important assessment programs. JF - Cancer investigation AU - Abnet, Christian C AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Rockville, Maryland 20852, USA. abnetc@mail.nih.gov PY - 2007 SP - 189 EP - 196 VL - 25 IS - 3 SN - 0735-7907, 0735-7907 KW - Carcinogens, Environmental KW - 0 KW - Index Medicus KW - Humans KW - Databases, Factual KW - Risk Assessment KW - Carcinogens, Environmental -- classification KW - Carcinogens, Environmental -- adverse effects KW - Neoplasms -- chemically induced KW - Neoplasms -- epidemiology KW - Food Contamination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70553430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+investigation&rft.atitle=Carcinogenic+food+contaminants.&rft.au=Abnet%2C+Christian+C&rft.aulast=Abnet&rft.aufirst=Christian&rft.date=2007-04-01&rft.volume=25&rft.issue=3&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Cancer+investigation&rft.issn=07357907&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-03 N1 - Date created - 2007-05-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 1994 Oct 15;59(2):155-8 [7927911] Int J Epidemiol. 1994 Jun;23(3):444-50 [7960367] Cancer Causes Control. 1995 Jul;6(4):361-8 [7548724] Jpn J Clin Oncol. 1996 Feb;26(1):42-8 [8551666] Eur J Cancer Prev. 1997 Jun;6(3):226-68 [9306073] Food Chem Toxicol. 1997 Dec;35(12):1143-50 [9449219] Int J Cancer. 1998 Jul 17;77(2):228-35 [9650558] Eur J Cancer. 1998 Apr;34(5):757-8 [9713287] J Toxicol Sci. 1998 Jul;23 Suppl 2:160-4 [9760455] J Epidemiol Community Health. 1998 Dec;52(12):812-7 [10396523] Int J Cancer. 2006 Jan 1;118(1):169-73 [16003738] Alcohol Alcohol. 2004 May-Jun;39(3):155-65 [15082451] J Gastroenterol Hepatol. 2004 Jun;19(6):632-7 [15151616] Sci Total Environ. 2004 Sep 20;331(1-3):143-55 [15325146] Environ Health Perspect. 2004 Sep;112(13):1265-8 [15345337] Gastroenterology. 2004 Nov;127(5 Suppl 1):S310-8 [15508099] Br J Cancer. 1973 Jun;27(6):473-84 [4721221] J Agric Food Chem. 1979 Sep-Oct;27(5):1108-12 [161914] J Natl Cancer Inst. 1981 Jan;66(1):33-6 [7005503] Int J Epidemiol. 1982 Jun;11(2):112-9 [7095960] Nutr Cancer. 1982;3(4):257-68 [6890672] Food Chem Toxicol. 1984 Jan;22(1):39-43 [6537935] Int J Cancer. 1989 May 15;43(5):755-61 [2714880] J Natl Cancer Inst. 1990 Feb 21;82(4):291-6 [2299678] Br J Cancer. 1990 May;61(5):737-40 [2337510] Appl Environ Microbiol. 1990 Dec;56(12):3723-6 [2150585] Cancer Res. 2005 Dec 15;65(24):11779-84 [16357191] Carcinogenesis. 1980 Aug;1(8):685-92 [11272122] Environ Health Perspect. 2001 Mar;109 Suppl 1:35-47 [11250804] Int J Cancer. 2001 Feb 15;91(4):568-74 [11251983] Environ Health Perspect. 2001 May;109 Suppl 2:277-82 [11359696] Cancer Causes Control. 2001 Nov;12(9):821-8 [11714110] Mutat Res. 1999 Jul 15;443(1-2):129-38 [10415436] Clin Liver Dis. 1998 Feb;2(1):103-18 [15560048] Int J Cancer. 2005 Jan 20;113(3):456-63 [15455378] Alcohol. 2005 Apr;35(3):195-203 [16054981] Alcohol. 2005 Apr;35(3):213-25 [16054983] J Agric Food Chem. 2000 May;48(5):1860-4 [10820105] Food Addit Contam. 2000 Apr;17(4):289-302 [10912243] Eur J Cancer Prev. 2000 Aug;9(4):241-56 [10958327] Int J Cancer. 2001 Jan 15;91(2):252-9 [11146454] Food Addit Contam. 2002 Mar;19(3):282-302 [11834078] Environ Health Perspect. 2002 Feb;110(2):125-8 [11836138] Curr Med Chem. 2002 Mar;9(6):675-86 [11945131] Oral Oncol. 2002 Oct;38(7):646-9 [12167417] Alcohol Alcohol. 2002 Sep-Oct;37(5):409-15 [12217928] Mutat Res. 2002 Sep 30;506-507:197-204 [12351159] Occup Environ Med. 2002 Oct;59(10):655-63 [12356924] Br J Cancer. 2003 Jan 13;88(1):84-9 [12556964] Int J Cancer. 2003 Apr 20;104(4):458-61 [12584743] Jpn J Clin Oncol. 2003 Mar;33(3):111-21 [12672787] Int J Cancer. 2003 Jul 1;105(4):558-60 [12712450] Crit Rev Clin Lab Sci. 2003 Apr;40(2):183-208 [12755455] Head Neck. 2003 Jul;25(7):595-601 [12808663] Cancer Epidemiol Biomarkers Prev. 2003 Jun;12(6):508-13 [12814995] J Expo Anal Environ Epidemiol. 2003 Jul;13(4):267-75 [12923553] Eur J Cancer Prev. 2003 Oct;12(5):417-25 [14512807] Br J Cancer. 2003 Oct 6;89(7):1209-14 [14520448] Food Chem Toxicol. 2004 Jan;42(1):51-63 [14630130] Carcinogenesis. 2003 Dec;24(12):1951-60 [12970071] Cancer Epidemiol Biomarkers Prev. 2004 Feb;13(2):293-8 [14973110] Int J Cancer. 2004 May 1;109(5):774-6 [14999788] Mutat Res. 1992 Feb;265(2):211-21 [1370720] Lancet. 1992 Apr 18;339(8799):943-6 [1348796] J Natl Cancer Inst. 1993 Apr 21;85(8):648-52 [8468722] Lancet. 1993 Jun 5;341(8858):1432-7 [8099140] Chin Med Sci J. 1992 Dec;7(4):201-4 [1307494] S Afr Med J. 1993 Jun;83(6):382-3 [8211450] IARC Sci Publ. 1993;(124):141-8 [8225477] Pharmacogenetics. 1993 Oct;3(5):213-30 [8287061] Acta Otolaryngol. 1994 Jan;114(1):98-104 [7510449] J Natl Cancer Inst. 1994 Apr 20;86(8):589-99 [8145274] Appl Environ Microbiol. 1994 Mar;60(3):847-52 [8161178] Appl Environ Microbiol. 1994 May;60(5):1626-9 [8017941] Annu Rev Pharmacol Toxicol. 1994;34:343-72 [8042855] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Peripheral neurotoxicity of weekly paclitaxel chemotherapy: a schedule or a dose issue? AN - 70521405; 17509163 AB - The rationale for intensification strategies is that more frequent exposure to chemotherapeutics could enhance antitumor activity. Several trials investigated weekly paclitaxel administration, but there are no clear data concerning peripheral neurotoxicity. The aim of this study was to assess the incidence of peripheral neurotoxicity in patients affected by advanced breast cancer treated with weekly paclitaxel. Neurotoxicity was assessed with neurologic and neurophysiologic evaluation before treatment and after 12 weeks and 24 weeks. A total neurotoxicity score was assigned to each patient on the basis of neurophysiologic and neuropathic signs and symptom changes. Seventeen patients entered the study. After 12 weeks of treatment, 71% showed moderate clinical and/or neurophysiologic signs of neurotoxicity; after 24 weeks, the incidence of neurotoxicity increased to 96%. Sural amplitude at the 24-weeks examination significantly decreased from basal mean value (13.5 microv, standard deviation [SD] 6 microv vs. 7 microv, SD 5.9 microv, respectively; P = 0.01), whereas median sensory amplitude decreased after 24 weeks from 10.3 microv, SD 6.2 microv to 4.9 microv, SD 3.8 microv (P = 0.001). In a subset of 11 patients, we obtained a follow-up examination after 6 months from the end of treatment. In all patients, examined signs and symptoms of neurotoxicity improved with recovery of subjective neuropathic symptoms and neurophysiologic findings. Our results demonstrate, in a little population of patients evaluated with a comprehensive neurologic assessment, that weekly paclitaxel is related to a very high incidence of peripheral neurotoxicity. Follow-up data obtained in a subset of patients indicate that peripheral neurotoxicity is reversible. JF - Clinical breast cancer AU - Pace, Andrea AU - Nisticò, Cecilia AU - Cuppone, Federica AU - Bria, Emilio AU - Galiè, Edvina AU - Graziano, Giuliana AU - Natoli, Guido AU - Sperduti, Isabella AU - Jandolo, Bruno AU - Calabretta, Francesca AU - Tomao, Silverio AU - Terzoli, Edmondo AD - Department of Neurology, Regina Elena National Cancer Institute, Rome, Italy. Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 550 EP - 554 VL - 7 IS - 7 SN - 1526-8209, 1526-8209 KW - Antineoplastic Agents, Phytogenic KW - 0 KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Drug Administration Schedule KW - Dose-Response Relationship, Drug KW - Humans KW - Treatment Outcome KW - Middle Aged KW - Follow-Up Studies KW - Time Factors KW - Female KW - Peripheral Nervous System Diseases -- epidemiology KW - Paclitaxel -- administration & dosage KW - Breast Neoplasms -- drug therapy KW - Paclitaxel -- adverse effects KW - Antineoplastic Agents, Phytogenic -- adverse effects KW - Peripheral Nervous System Diseases -- chemically induced KW - Antineoplastic Agents, Phytogenic -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70521405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+breast+cancer&rft.atitle=Peripheral+neurotoxicity+of+weekly+paclitaxel+chemotherapy%3A+a+schedule+or+a+dose+issue%3F&rft.au=Pace%2C+Andrea%3BNistic%C3%B2%2C+Cecilia%3BCuppone%2C+Federica%3BBria%2C+Emilio%3BGali%C3%A8%2C+Edvina%3BGraziano%2C+Giuliana%3BNatoli%2C+Guido%3BSperduti%2C+Isabella%3BJandolo%2C+Bruno%3BCalabretta%2C+Francesca%3BTomao%2C+Silverio%3BTerzoli%2C+Edmondo&rft.aulast=Pace&rft.aufirst=Andrea&rft.date=2007-04-01&rft.volume=7&rft.issue=7&rft.spage=550&rft.isbn=&rft.btitle=&rft.title=Clinical+breast+cancer&rft.issn=15268209&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-03 N1 - Date created - 2007-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Occupation and adult-onset asthma among Chinese women in a population-based cohort. AN - 70447292; 17311256 AB - Exposure to industrial irritants is believed to have contributed to the increasing prevalence of asthma worldwide. We examined the associations between occupation and asthma among women in a case-control study nested in the population-based Shanghai Women's Health Study cohort in China. Cases were 1,050 women who reported a physician-diagnosed asthma as adults. Controls were 4,200 women matched to the cases by year of birth and age at diagnosis. Lifetime occupational histories were obtained. Logistic regression was applied to estimate odds ratios (ORs) adjusting for smoking, education, family income, and concurrent chronic bronchitis. Asthma is more prevalent in production industries for metal tools (OR = 2.4; 1.3-4.7), metal products for everyday use (OR = 1.6; 1.1-2.4), ships (OR = 2.6; 1.0-6.8), and clocks (OR = 1.9; 1.0-3.4), and in occupations as farm workers (OR = 4.0; 1.2-13.0), laboratory technicians and analyzers (OR = 2.2; 1.2-3.9), and installation and maintenance workers for weaving and knitting machineries (OR = 2.4; 1.1-5.4). Other associations less commonly reported were identified for electricians (OR = 2.1; 1.1-4.1), performers (OR = 3.2; 1.4-7.4), administrative workers in organizations and enterprises (OR = 1.8; 1.1-2.8), and postal and telecommunication workers (OR = 3.5; 1.6-7.6). Our findings suggest that occupational exposures contribute to the development of asthma in women. JF - American journal of industrial medicine AU - Krstev, Srmena AU - Ji, Bu-Tian AU - Shu, Xiao-Ou AU - Blair, Aaron AU - Zheng, Wei AU - Lubin, Jay AU - Vermeulen, Roel AU - Hauptmann, Michael AU - Rothman, Nathaniel AU - Gao, Yu-Tang AU - Mustafa, Dosemeci AU - Chow, Wong-Ho AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892, USA. Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 265 EP - 273 VL - 50 IS - 4 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - Age Factors KW - Sex Factors KW - Risk Factors KW - Humans KW - China -- epidemiology KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Developing Countries KW - Adolescent KW - Female KW - Prevalence KW - Occupational Health KW - Asthma -- epidemiology KW - Occupational Diseases -- etiology KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70447292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Occupation+and+adult-onset+asthma+among+Chinese+women+in+a+population-based+cohort.&rft.au=Krstev%2C+Srmena%3BJi%2C+Bu-Tian%3BShu%2C+Xiao-Ou%3BBlair%2C+Aaron%3BZheng%2C+Wei%3BLubin%2C+Jay%3BVermeulen%2C+Roel%3BHauptmann%2C+Michael%3BRothman%2C+Nathaniel%3BGao%2C+Yu-Tang%3BMustafa%2C+Dosemeci%3BChow%2C+Wong-Ho&rft.aulast=Krstev&rft.aufirst=Srmena&rft.date=2007-04-01&rft.volume=50&rft.issue=4&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-06 N1 - Date created - 2007-04-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Developmental research on alcohol and spirituality: what we know and what we don't know. AN - 70438063; 17458416 JF - Southern medical journal AU - Calhoun, Faye J AD - National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA. fbroadwater@verizon.net Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 427 EP - 429 VL - 100 IS - 4 SN - 0038-4348, 0038-4348 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Humans KW - Research Support as Topic KW - Biomedical Research -- organization & administration KW - Spiritual Therapies -- methods KW - Spirituality KW - Alcohol-Related Disorders -- prevention & control KW - Alcohol-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70438063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Southern+medical+journal&rft.atitle=Developmental+research+on+alcohol+and+spirituality%3A+what+we+know+and+what+we+don%27t+know.&rft.au=Calhoun%2C+Faye+J&rft.aulast=Calhoun&rft.aufirst=Faye&rft.date=2007-04-01&rft.volume=100&rft.issue=4&rft.spage=427&rft.isbn=&rft.btitle=&rft.title=Southern+medical+journal&rft.issn=00384348&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-08 N1 - Date created - 2007-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cerebrospinal fluid from amyotrophic lateral sclerosis patients causes fragmentation of the Golgi apparatus in the neonatal rat spinal cord. AN - 70423272; 17453633 AB - We have previously shown in our laboratory that cerebrospinal fluid from ALS patients (ALS-CSF) contains putative toxic factor(s). In the present study we determined the effect of ALS-CSF on the integrity of the Golgi apparatus of spinal motor neurons in the neonatal rats. CSF was injected intrathecally into three-day-old rat pups and subsequently the ultrastructural changes in the motor neurons were studied after 48 h, 1, 2 and 3 weeks. We observed that ALS-CSF causes fragmentation of the Golgi apparatus in a considerable number of motor neurons in the spinal cord. This was further confirmed when motor neurons were stained with an antibody against a medial Golgi protein (MG160). Thus, we suggest that the putative toxin(s) present in ALS-CSF may cause impairment in the protein processing leading to motor neuron death. JF - Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases AU - Ramamohan, Priti Y AU - Gourie-Devi, M AU - Nalini, A AU - Shobha, K AU - Ramamohan, Y AU - Joshi, Preeti AU - Raju, T R AD - Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Bangalore, India. Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 79 EP - 82 VL - 8 IS - 2 SN - 1748-2968, 1748-2968 KW - Cerebrospinal Fluid Proteins KW - 0 KW - Index Medicus KW - Rats KW - Animals, Newborn KW - Animals KW - Injections, Spinal KW - Humans KW - Rats, Wistar KW - Motor Neurons -- pathology KW - Amyotrophic Lateral Sclerosis -- cerebrospinal fluid KW - Golgi Apparatus -- drug effects KW - Cerebrospinal Fluid Proteins -- administration & dosage KW - Spinal Cord -- drug effects KW - Spinal Cord -- pathology KW - Golgi Apparatus -- pathology KW - Motor Neurons -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70423272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Amyotrophic+lateral+sclerosis+%3A+official+publication+of+the+World+Federation+of+Neurology+Research+Group+on+Motor+Neuron+Diseases&rft.atitle=Cerebrospinal+fluid+from+amyotrophic+lateral+sclerosis+patients+causes+fragmentation+of+the+Golgi+apparatus+in+the+neonatal+rat+spinal+cord.&rft.au=Ramamohan%2C+Priti+Y%3BGourie-Devi%2C+M%3BNalini%2C+A%3BShobha%2C+K%3BRamamohan%2C+Y%3BJoshi%2C+Preeti%3BRaju%2C+T+R&rft.aulast=Ramamohan&rft.aufirst=Priti&rft.date=2007-04-01&rft.volume=8&rft.issue=2&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Amyotrophic+lateral+sclerosis+%3A+official+publication+of+the+World+Federation+of+Neurology+Research+Group+on+Motor+Neuron+Diseases&rft.issn=17482968&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-07 N1 - Date created - 2007-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Parental smoking modifies the relation between genetic variation in tumor necrosis factor-alpha (TNF) and childhood asthma. AN - 70412815; 17450233 AB - Polymorphisms in the proinflammatory cytokine genes tumor necrosis factor-alpha (TNF) and lymphotoxin-alpha (LTA, also called TNF-beta) have been associated with asthma and atopy in some studies. Parental smoking is a consistent risk factor for childhood asthma. Secondhand smoke and ozone both stimulate TNF production. Our goal was to investigate whether genetic variation in TNF and LTA is associated with asthma and atopy and whether the association is modified by parental smoking in a Mexican population with high ozone exposure. We genotyped six tagging single nucleotide polymorphisms (SNPs) in TNF and LTA, including functional variants, in 596 nuclear families consisting of asthmatics 4-17 years of age and their parents in Mexico City. Atopy was determined by skin prick tests. The A allele of the TNF-308 SNP was associated with increased risk of asthma [relative risk (RR) = 1.54; 95% confidence interval (CI), 1.04-2.28], especially among children of non-smoking parents (RR = 2.06; 95% CI, 1.19-3.55; p for interaction = 0.09). Similarly, the A allele of the TNF-238 SNP was associated with increased asthma risk among children of nonsmoking parents (RR = 2.21; 95% CI, 1.14-4.30; p for interaction = 0.01). LTA SNPs were not associated with asthma. Haplotype analyses reflected the single SNP findings in magnitude and direction. TNF and LTA SNPs were not associated with the degree of atopy. Our results suggest that genetic variation in TNF may contribute to childhood asthma and that associations may be modified by parental smoking. JF - Environmental health perspectives AU - Wu, Hao AU - Romieu, Isabelle AU - Sienra-Monge, Juan-Jose AU - del Rio-Navarro, Blanca Estela AU - Anderson, Daniel M AU - Dunn, Erin W AU - Steiner, Lori L AU - Lara-Sanchez, Irma del Carmen AU - London, Stephanie J AD - Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health/DHHS, Research Triangle Park, NC 27709, USA. Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 616 EP - 622 VL - 115 IS - 4 SN - 0091-6765, 0091-6765 KW - Lymphotoxin-alpha KW - 0 KW - Tobacco Smoke Pollution KW - Tumor Necrosis Factor-alpha KW - Ozone KW - 66H7ZZK23N KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Humans KW - Parent-Child Relations KW - Child KW - Child, Preschool KW - Genotype KW - Risk Factors KW - Adult KW - Environmental Exposure KW - Hypersensitivity, Immediate KW - Mexico -- epidemiology KW - Adolescent KW - Female KW - Male KW - Asthma -- epidemiology KW - Lymphotoxin-alpha -- genetics KW - Asthma -- genetics KW - Tobacco Smoke Pollution -- adverse effects KW - Tumor Necrosis Factor-alpha -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70412815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Conformation+of+the+HIV-1+Gag+Protein+in+Solution&rft.au=Datta%2C+SAK%3BCurtis%2C+JE%3BRatcliff%2C+W%3BClark%2C+P+K%3BCrist%2C+R+M%3BLebowitz%2C+J%3BKrueger%2C+S%3BRein%2C+A&rft.aulast=Datta&rft.aufirst=SAK&rft.date=2007-01-19&rft.volume=365&rft.issue=3&rft.spage=812&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2006.10.073 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-22 N1 - Date created - 2007-04-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Respir Crit Care Med. 1999 Jul;160(1):278-82 [10390412] Thorax. 1999 Sep;54(9):757-61 [10456966] Clin Exp Allergy. 1999 Sep;29(9):1204-8 [10469028] Immunol Allergy Clin North Am. 2005 Feb;25(1):15-30 [15579362] Hum Genomics. 2004 Mar;1(3):209-17 [15588480] Am J Respir Crit Care Med. 2005 Jan 15;171(2):171-6 [15486341] Clin Exp Allergy. 2005 Jun;35(6):790-6 [15969671] Am J Respir Crit Care Med. 2005 Sep 15;172(6):687-92 [15976383] Eur Respir J. 2005 Oct;26(4):637-46 [16204594] Immunol Allergy Clin North Am. 2005 Nov;25(4):709-21 [16257634] Am J Respir Crit Care Med. 2005 Dec 15;172(12):1563-8 [16166621] J Investig Allergol Clin Immunol. 2002;12(3):192-7 [12530118] Pediatr Pulmonol. 2003 Mar;35(3):177-83 [12567385] Chest. 2003 Feb;123(2):475-80 [12576369] Hum Immunol. 2003 Mar;64(3):359-65 [12590981] Chest. 2003 Mar;123(3 Suppl):374S-5S [12628988] Thorax. 2003 Feb;58 Suppl 1:i1-94 [12653493] Am J Respir Crit Care Med. 2003 Apr 15;167(8):1083-9 [12522030] Am J Hum Genet. 2000 Jan;66(1):251-61 [10631155] Am J Respir Crit Care Med. 2000 May;161(5):1655-9 [10806171] Eur Respir J. 2000 Oct;16(4):604-8 [11106199] Hum Genet. 2000 Dec;107(6):591-6 [11153913] Am J Hum Genet. 2001 Apr;68(4):978-89 [11254454] Immunol Cell Biol. 2001 Apr;79(2):132-40 [11264706] Eur J Hum Genet. 2001 Apr;9(4):301-6 [11313775] Int Arch Allergy Immunol. 2001 Aug;125(4):297-306 [11574751] Clin Exp Allergy. 2001 Sep;31(9):1418-23 [11591192] Hum Mutat. 2001 Oct;18(4):327-36 [11668616] Eur J Hum Genet. 2002 Jan;10(1):82-5 [11896460] Clin Exp Allergy. 2002 Jun;32(6):838-42 [12047428] J Allergy Clin Immunol. 2003 Apr;111(4):840-6 [12704367] Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9440-5 [12883005] Am J Respir Crit Care Med. 2003 Nov 15;168(10):1199-204 [12969868] Allergy. 2004 Jan;59(1):61-4 [14674935] Nucleic Acids Res. 2004 Jan 1;32(Database issue):D528-32 [14681474] Am J Hum Genet. 2004 Jan;74(1):106-20 [14681826] Hum Mol Genet. 2004 Feb 15;13(4):397-403 [14681301] Ann Hum Genet. 2004 Jan;68(Pt 1):55-64 [14748830] Clin Exp Allergy. 2004 Feb;34(2):184-8 [14987295] Nat Genet. 2004 Apr;36(4):394-9 [15052269] Int J Tuberc Lung Dis. 2004 May;8(5):519-27 [15137526] Ann Neurol. 2004 Jun;55(6):793-800 [15174013] Genet Epidemiol. 2004 Jul;27(1):33-42 [15185401] J Allergy Clin Immunol. 2006 Jan;117(1):119-26 [16387594] J Asthma. 2005 Dec;42(10):839-41 [16393721] Genome Res. 2006 Mar;16(3):323-30 [16467560] Am J Respir Crit Care Med. 2006 May 1;173(9):970-6 [16456144] Ann Hum Genet. 2006 May;70(Pt 3):382-96 [16674560] Thorax. 2006 Jun;61(6):466-71 [16517578] Am J Respir Cell Mol Biol. 2006 Oct;35(4):488-95 [16728705] Am J Respir Crit Care Med. 2002 Jul 1;166(1):43-6 [12091169] Allergy. 2002 Sep;57(9):831-4 [12169181] Am J Respir Crit Care Med. 2002 Sep 1;166(5):703-9 [12204869] Nat Genet. 2002 Dec;32(4):650-4 [12426569] Immunol Allergy Clin North Am. 2004 Nov;24(4):583-97, v-vi [15474860] Int Arch Allergy Appl Immunol. 1973;45(1):57-60 [4580380] J Exp Med. 1991 Jan 1;173(1):209-19 [1670638] Am Rev Respir Dis. 1992 Feb;145(2 Pt 1):332-6 [1736737] Am J Respir Cell Mol Biol. 1994 May;10(5):471-80 [8179909] Am J Respir Cell Mol Biol. 1995 Jul;13(1):60-8 [7598938] Am J Respir Crit Care Med. 1995 Jul;152(1):76-80 [7599866] Biochem Biophys Res Commun. 1995 Jul 26;212(3):879-86 [7626125] Am J Respir Crit Care Med. 1995 Sep;152(3):1107-36 [7663792] Nature. 1996 Sep 19;383(6597):247-50 [8805698] Nat Genet. 1997 Apr;15(4):389-92 [9090385] Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3195-9 [9096369] Hum Mol Genet. 1997 Apr;6(4):551-4 [9097957] Mol Immunol. 1997 Apr;34(5):391-9 [9293772] Nat Genet. 1997 Dec;17(4):475-8 [9398854] Am J Hum Genet. 1998 Apr;62(4):969-78 [9529360] Am J Hum Genet. 1998 Jul;63(1):259-66 [9634505] Clin Exp Allergy. 1998 May;28(5):578-84 [9645594] Clin Exp Immunol. 1998 Sep;113(3):401-6 [9737669] Am J Epidemiol. 1998 Nov 1;148(9):893-901 [9801020] J Med Genet. 1999 Apr;36(4):323-5 [10227402] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification of genes implicated in methapyrilene-induced hepatotoxicity by comparing differential gene expression in target and nontarget tissue. AN - 70407149; 17450226 AB - Toxicogenomics experiments often reveal thousands of transcript alterations that are related to multiple processes, making it difficult to identify key gene changes that are related to the toxicity of interest. The objective of this study was to compare gene expression changes in a nontarget tissue to the target tissue for toxicity to help identify toxicity-related genes. Male rats were given the hepatotoxicant methapyrilene at two dose levels, with livers and kidneys removed 24 hr after one, three, and seven doses for gene expression analysis. To identify gene changes likely to be related to toxicity, we analyzed genes on the basis of their temporal pattern of change using a program developed at the National Institute of Environmental Health Sciences, termed "EPIG" (extracting gene expression patterns and identifying co-expressed genes). High-dose methapyrilene elicited hepatic damage that increased in severity with the number of doses, whereas no treatment-related lesions were observed in the kidney. High-dose methapyrilene elicited thousands of gene changes in the liver at each time point, whereas many fewer gene changes were observed in the kidney. EPIG analysis identified patterns of gene expression correlated to the observed toxicity, including genes associated with endoplasmic reticulum stress and the unfolded protein response. By factoring in dose level, number of doses, and tissue into the analysis of gene expression elicited by methapyrilene, we were able to identify genes likely to not be implicated in toxicity, thereby allowing us to focus on a subset of genes to identify toxicity-related processes. JF - Environmental health perspectives AU - Auman, J Todd AU - Chou, Jeff AU - Gerrish, Kevin AU - Huang, Qihong AU - Jayadev, Supriya AU - Blanchard, Kerry AU - Paules, Richard S AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 572 EP - 578 VL - 115 IS - 4 SN - 0091-6765, 0091-6765 KW - Histamine H1 Antagonists KW - 0 KW - Methapyrilene KW - A01LX40298 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Kidney -- pathology KW - Dose-Response Relationship, Drug KW - Kidney -- drug effects KW - Male KW - Gene Expression Profiling KW - Liver -- pathology KW - Liver -- drug effects KW - Up-Regulation -- drug effects KW - Methapyrilene -- toxicity KW - Histamine H1 Antagonists -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70407149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Identification+of+genes+implicated+in+methapyrilene-induced+hepatotoxicity+by+comparing+differential+gene+expression+in+target+and+nontarget+tissue.&rft.au=Auman%2C+J+Todd%3BChou%2C+Jeff%3BGerrish%2C+Kevin%3BHuang%2C+Qihong%3BJayadev%2C+Supriya%3BBlanchard%2C+Kerry%3BPaules%2C+Richard+S&rft.aulast=Auman&rft.aufirst=J&rft.date=2007-04-01&rft.volume=115&rft.issue=4&rft.spage=572&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-22 N1 - Date created - 2007-04-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Lett. 1999 Jul 30;108(1):37-46 [10472808] Toxicol Sci. 1998 Nov;46(1):185-96 [9928682] Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2063-8 [15684063] J Pharmacol Exp Ther. 2005 May;313(2):780-9 [15665138] Nat Methods. 2005 May;2(5):351-6 [15846362] Toxicol Sci. 2005 Jul;86(1):185-93 [15814895] Annu Rev Biochem. 2005;74:739-89 [15952902] Oncogene. 2005 Jul 21;24(31):4921-33 [15897896] Cell Biol Toxicol. 2005 Sep-Nov;21(5-6):215-31 [16323058] Int J Biochem Cell Biol. 2006 Mar;38(3):317-32 [16290097] Environ Health Perspect. 2006 Jan;114(1):92-9 [16393664] Toxicology. 2006 Feb 15;219(1-3):175-86 [16368179] Cell Death Differ. 2006 Mar;13(3):363-73 [16397583] Environ Health Perspect. 2006 Apr;114(4):553-9 [16581545] Bioinformatics. 2006 May 1;22(9):1111-21 [16522673] Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E275-81 [16492686] Nature. 2000 Jul 27;406(6794):435-9 [10935643] Chem Biol Interact. 2000 Dec 15;129(3):279-95 [11137066] Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3369-74 [11248085] Hepatology. 2001 May;33(5):1239-58 [11343254] Curr Opin Cell Biol. 2001 Jun;13(3):349-55 [11343907] Nucleic Acids Res. 2002 Jan 1;30(1):207-10 [11752295] Toxicol Sci. 2002 Jan;65(1):135-50 [11752693] Pharmacogenetics. 2002 Jan;12(1):55-65 [11773865] Pharmacogenomics J. 2002;2(2):117-26 [12049174] Biochem Biophys Res Commun. 2002 Apr 26;293(1):145-9 [12054576] Toxicol Pathol. 2002 Jul-Aug;30(4):470-82 [12187938] J Biol Chem. 2003 Jan 24;278(4):2563-70 [12421815] Biochem Pharmacol. 2003 Mar 1;65(5):857-75 [12628495] Gastroenterology. 2003 May;124(5):1488-99 [12730887] Toxicol Sci. 2003 Jun;73(2):315-28 [12700408] J Biol Chem. 2003 Nov 14;278(46):45062-71 [12923173] Environ Health Perspect. 2004 Mar;112(4):439-48 [15033593] Environ Health Perspect. 2004 Mar;112(4):465-79 [15033597] Mutat Res. 2004 May 18;549(1-2):101-13 [15120965] Mutat Res. 2004 May 18;549(1-2):169-83 [15120969] Toxicol Sci. 2004 Jul;80(1):193-202 [15084756] Science. 1980 Aug 15;209(4458):817-9 [7403848] Biochem Pharmacol. 1991 Aug 8;42(5):1093-7 [1872894] Toxicology. 1998 Sep 15;130(2-3):79-93 [9865476] Nat Rev Genet. 2004 Dec;5(12):936-48 [15573125] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of the vascular targeting agent combretastatin a-4 prodrug on retinal neovascularization in the galactose-fed dog. AN - 70406457; 17444801 AB - Combretastatin A-4 (CA-4) is a vascular targeting agent known to rapidly shut off blood flow in new vessels and, as a result, regress neovascularization. In this pilot study, the ability of CA-4 to modify retinal neovascularization, which results in altered retinal vessel blood flow and retinal permeability, was evaluated in aphakic long-term galactose-fed beagles, an animal model that develops diabetes-like retinal neovascularization. Two (2) groups of aphakic dogs, each group comprised of 4 galactose-fed dogs and 2 age-matched controls dogs, were utilized. Each group initially received the combretastatin A-4-phosphate prodrug (CA-4P) as either sub-Tenon's injections, administered at the corneoscleral junction, or intravitreal injections. Six (6) weeks after this treatment, all dogs also received systemic (intravenous) injections of CA-4P. Retinal vascular changes were monitored at 2-week intervals by fluorescein angiography. All galactose-fed dogs demonstrated the presence of retinal neovascular lesions by fluorescein angiograms. Fluorescein leakage or perfusion through neovascular vessels was not altered by either sub-Tenon's, intravitreal, or systemic CA-4P administration. Whereas CA-4P was well tolerated by the healthy eyes of the control animals, its administration to some galactose-fed dogs was associated with corneal edema and increases in intraocular pressure following sub-Tenon's and intraocular injections. Neovascularization in the galactose-fed dog progresses over a period of years, similar to that observed with clinical diabetic retinopathy. The failure of CA-4P to ameliorate neovascularization suggests that chronic, long-term administration may be required to destroy the slowly growing retinal endothelial cells. JF - Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics AU - Kador, Peter F AU - Blessing, Karen AU - Randazzo, James AU - Makita, Jun AU - Wyman, Milton AD - Laboratory of Ocular Therapeutics, National Eye Institute, National Institutes of Health, Bethesda, MD, USA. pkador@unmc.edu Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 132 EP - 142 VL - 23 IS - 2 SN - 1080-7683, 1080-7683 KW - Antineoplastic Agents, Phytogenic KW - 0 KW - Prodrugs KW - Stilbenes KW - fosbretabulin KW - I5590ES2QZ KW - Galactose KW - X2RN3Q8DNE KW - Index Medicus KW - Intraocular Pressure -- drug effects KW - Animals KW - Aphakia KW - Fluorescein Angiography KW - Dogs KW - Retinal Vessels -- drug effects KW - Disease Models, Animal KW - Injections KW - Retinal Vessels -- pathology KW - Diabetic Retinopathy -- chemically induced KW - Stilbenes -- pharmacology KW - Prodrugs -- pharmacology KW - Stilbenes -- administration & dosage KW - Retinal Neovascularization -- chemically induced KW - Antineoplastic Agents, Phytogenic -- pharmacology KW - Retinal Neovascularization -- drug therapy KW - Diabetic Retinopathy -- drug therapy KW - Antineoplastic Agents, Phytogenic -- administration & dosage KW - Prodrugs -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70406457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Genome+Instability+and+Repair+%28A5%29&rft.atitle=p53+Biological+Network%3A+Inflammation%2C+microRNA+and+Cancer&rft.au=Harris%2C+Curtis+C&rft.aulast=Harris&rft.aufirst=Curtis&rft.date=2007-01-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Genome+Instability+and+Repair+%28A5%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-07 N1 - Date created - 2007-04-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The anticonvulsant activity of acetone, the major ketone body in the ketogenic diet, is not dependent on its metabolites acetol, 1,2-propanediol, methylglyoxal, or pyruvic acid. AN - 70388073; 17386058 AB - Acetone, one of the principal ketone bodies elevated during treatment with the ketogenic diet, exhibits anticonvulsant properties that may contribute to the seizure protection conferred by the diet. The anticonvulsant mechanism of acetone is unknown, but it is metabolized to several bioactive substances that could play a role. Acetone and its major metabolites-acetol, 1,2-propanediol, methylglyoxal, and pyruvic acid-were assessed for anticonvulsant activity in two mouse seizure models. Various doses of the substances administered intraperitoneally were characterized for their ability to elevate the threshold for clonic seizures induced by intravenous infusion of pentylenetetrazol (PTZ) and for protection against tonic seizures induced by subcutaneous bolus administration of 4-aminopyridine (4-AP). The inverted-screen test was used to assess acute neurological toxicity. Acetone (1-32 mmol/kg, i.p.), in a dose-dependent fashion, elevated the PTZ threshold and conferred protection against 4-AP seizures (ED(50), 26.3 mmol/kg). Effective doses of acetone (10-32 mmol/kg) did not cause motor impairment in the inverted-screen test (TD(50), 45.7 mmol/kg). In doses 10-fold greater than the minimally effective dose of acetone (3.2 mmol/kg), the metabolites acetol, 1,2-propanediol, and pyruvic acid were inactive in the PTZ model. At higher doses that produced motor impairment, acetol and 1,2-propanediol (but not pyruvic acid) did elevate the PTZ threshold. Methylglyoxal had both proconvulsant and anticonvulsant actions, and had substantial toxicity, producing respiratory distress, motor impairment, and death. None of the acetone metabolites protected against 4-AP seizures. This study confirms the broad-spectrum anticonvulsant properties of acetone and indicates that the seizure protection conferred is unlikely to result from its major metabolic products. JF - Epilepsia AU - Gasior, Maciej AU - French, Amy AU - Joy, Michelle T AU - Tang, Rebecca S AU - Hartman, Adam L AU - Rogawski, Michael A AD - Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-3702, USA. Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 793 EP - 800 VL - 48 IS - 4 SN - 0013-9580, 0013-9580 KW - Anticonvulsants KW - 0 KW - Ketone Bodies KW - Acetone KW - 1364PS73AF KW - Malondialdehyde KW - 4Y8F71G49Q KW - Pyruvaldehyde KW - 722KLD7415 KW - acetol KW - 7I7YM0835W KW - Pyruvic Acid KW - 8558G7RUTR KW - Pentylenetetrazole KW - WM5Z385K7T KW - Index Medicus KW - Animals KW - Malondialdehyde -- pharmacology KW - Diet Therapy KW - Pyruvic Acid -- pharmacology KW - Disease Models, Animal KW - Mice KW - Epilepsy -- diet therapy KW - Pyruvaldehyde -- pharmacology KW - Seizures -- chemically induced KW - Anticonvulsants -- pharmacology KW - Ketone Bodies -- pharmacology KW - Acetone -- metabolism KW - Acetone -- pharmacology KW - Seizures -- prevention & control KW - Acetone -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70388073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epilepsia&rft.atitle=The+anticonvulsant+activity+of+acetone%2C+the+major+ketone+body+in+the+ketogenic+diet%2C+is+not+dependent+on+its+metabolites+acetol%2C+1%2C2-propanediol%2C+methylglyoxal%2C+or+pyruvic+acid.&rft.au=Gasior%2C+Maciej%3BFrench%2C+Amy%3BJoy%2C+Michelle+T%3BTang%2C+Rebecca+S%3BHartman%2C+Adam+L%3BRogawski%2C+Michael+A&rft.aulast=Gasior&rft.aufirst=Maciej&rft.date=2007-04-01&rft.volume=48&rft.issue=4&rft.spage=793&rft.isbn=&rft.btitle=&rft.title=Epilepsia&rft.issn=00139580&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-06 N1 - Date created - 2007-04-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Epilepsia. 2007 Oct;48(10):2002-3 [17922778] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - MeCP2 in Rett syndrome: transcriptional repressor or chromatin architectural protein? AN - 70379364; 17317146 AB - Rett syndrome is a progressive neurological disorder caused by mutations in the methyl-DNA binding protein MeCP2. The longstanding model depicting MeCP2 as a transcriptional repressor predicts that the Rett syndrome phenotype probably results from misregulation of MeCP2 target genes. Somewhat unexpectedly, the identification of such targets has proven challenging. The recent identification of two MeCP2 targets, BDNF and DLX5, are suggestive of two very different roles for this protein--one as a classical repressor protein, and the other as a mediator of a complex, specialized chromatin structure. JF - Current opinion in genetics & development AU - Chadwick, Lisa Helbling AU - Wade, Paul A AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 121 EP - 125 VL - 17 IS - 2 SN - 0959-437X, 0959-437X KW - Brain-Derived Neurotrophic Factor KW - 0 KW - Chromatin KW - DLX5 protein, human KW - Homeodomain Proteins KW - MECP2 protein, human KW - Methyl-CpG-Binding Protein 2 KW - Transcription Factors KW - Index Medicus KW - Homeodomain Proteins -- genetics KW - Humans KW - Mutation -- genetics KW - Transcription Factors -- genetics KW - Brain-Derived Neurotrophic Factor -- genetics KW - Methyl-CpG-Binding Protein 2 -- genetics KW - Rett Syndrome -- genetics KW - Models, Genetic KW - Chromatin -- genetics KW - Gene Expression Regulation -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70379364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+genetics+%26+development&rft.atitle=MeCP2+in+Rett+syndrome%3A+transcriptional+repressor+or+chromatin+architectural+protein%3F&rft.au=Chadwick%2C+Lisa+Helbling%3BWade%2C+Paul+A&rft.aulast=Chadwick&rft.aufirst=Lisa&rft.date=2007-04-01&rft.volume=17&rft.issue=2&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+genetics+%26+development&rft.issn=0959437X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-13 N1 - Date created - 2007-04-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor. AN - 70372531; 17428165 AB - P-glycoprotein actively transports structurally unrelated compounds out of cells, conferring the multidrug resistance phenotype in cancer. Tariquidar is a potent, specific, noncompetitive inhibitor of P-glycoprotein. Tariquidar inhibits the ATPase activity of P-glycoprotein, suggesting that the modulating effect is derived from the inhibition of substrate binding, inhibition of ATP hydrolysis or both. In clinical trials, tariquidar is tolerable and does not have significant pharmacokinetic interaction with chemotherapy. In patients, inhibition of P-glycoprotein has been demonstrated for 48 h after a single dose of tariquidar. Studies to assess a possible increase in toxicity of chemotherapy and the impact of P-glycoprotein inhibition on tumor response and patient outcome are ongoing. Tariquidar can be considered an ideal agent for testing the role of P-glycoprotein inhibition in cancer. JF - Expert review of anticancer therapy AU - Fox, Elizabeth AU - Bates, Susan E AD - National Cancer Institute, Pediatric Oncology Branch, Bethesda, MD 20892, USA. foxb@mail.nih.gov Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 447 EP - 459 VL - 7 IS - 4 KW - Antineoplastic Agents KW - 0 KW - P-Glycoprotein KW - Quinolines KW - tariquidar KW - J58862DTVD KW - Index Medicus KW - Neoplasms -- drug therapy KW - Animals KW - Protein Transport -- drug effects KW - Humans KW - Neoplasms -- epidemiology KW - Protein Transport -- physiology KW - Neoplasms -- metabolism KW - Quinolines -- pharmacology KW - P-Glycoprotein -- metabolism KW - Drug Resistance, Neoplasm KW - Antineoplastic Agents -- therapeutic use KW - Quinolines -- administration & dosage KW - P-Glycoprotein -- antagonists & inhibitors KW - Drug Resistance, Multiple UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70372531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+review+of+anticancer+therapy&rft.atitle=Tariquidar+%28XR9576%29%3A+a+P-glycoprotein+drug+efflux+pump+inhibitor.&rft.au=Fox%2C+Elizabeth%3BBates%2C+Susan+E&rft.aulast=Fox&rft.aufirst=Elizabeth&rft.date=2007-04-01&rft.volume=7&rft.issue=4&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=Expert+review+of+anticancer+therapy&rft.issn=1744-8328&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-31 N1 - Date created - 2007-04-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mouthwash as a low-cost and safe specimen transport medium for human papillomavirus DNA testing of cervicovaginal specimens. AN - 70363068; 17416781 AB - The usefulness of mouthwash as a transport medium for cervical specimens for carcinogenic human papillomavirus (HPV) DNA testing has not been evaluated. Two cervical specimens were collected from each of 34 patients, with one placed in mouthwash (Scope, Proctor and Gamble, Inc.) and the other in a liquid cytology medium commonly used for HPV DNA testing in alternating order. Paired specimens were tested by a PCR assay for carcinogenic HPV and a PCR HPV genotyping assay for 37 HPV types at 0, 3, and 6 weeks after collection; the results of the HPV genotyping assay were categorized into HPV risk groups according to cancer risk (HPV-16 > HPV-18 > other carcinogenic HPV types > noncarcinogenic HPV types > negative). After 4 months of storage, specimens were tested using a second, non-PCR test for carcinogenic HPV. We observed a >or=94% total agreement and kappa values of >or=0.88 between media at each time point for PCR-detected carcinogenic HPV. We observed a >or=74% total agreement, >or=0.62 unweighted kappa, and >or=0.75 linearly weighted kappa between media at each time point for PCR-detected HPV cancer risk category. Finally, we observed an 88% total agreement and kappa of 0.77 between media for carcinogenic HPV detection using a second test after 4 months of storage. We suggest that mouthwash might be used as a low-cost, safe, nonflammable storage and transport medium for cervical specimens for HPV DNA testing in cervical cancer screening programs. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Castle, Philip E AU - Sadorra, Mark AU - Garcia, Francisco A R AU - Cullen, Allison P AU - Lorincz, Attila T AU - Mitchell, Amy L AU - Whitby, Denise AU - Chuke, Ronald AU - Kornegay, Janet R AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Room 5004, EPS MSC 7234, Bethesda, MD 20892-7234, USA. castlep@mail.nih.gov Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 840 EP - 843 VL - 16 IS - 4 SN - 1055-9965, 1055-9965 KW - DNA, Viral KW - 0 KW - Drug Combinations KW - Quaternary Ammonium Compounds KW - Scope mouthwash KW - Cetylpyridinium KW - CUB7JI0JV3 KW - Index Medicus KW - Humans KW - Chi-Square Distribution KW - Female KW - Papillomavirus Infections -- diagnosis KW - DNA, Viral -- analysis KW - Papillomaviridae -- isolation & purification KW - Specimen Handling -- methods KW - Uterine Cervical Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70363068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Helicobacter+pylori+and+oesophageal+and+gastric+cancers+in+a+prospective+study+in+China&rft.au=Kamangar%2C+F%3BQiao%2C+Y-L%3BBlaser%2C+M+J%3BSun%2C+X-D%3BKatki%2C+H%3BFan%2C+J-H%3BPerez-Perez%2C+G+I%3BAbnet%2C+C+C%3BZhao%2C+P%3BMark%2C+S+D%3BTaylor%2C+P+R%3BDawsey%2C+S+M&rft.aulast=Kamangar&rft.aufirst=F&rft.date=2007-01-15&rft.volume=96&rft.issue=1&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6603517 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-05 N1 - Date created - 2007-04-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lifetime weight history and endometrial cancer risk by type of menopausal hormone use in the NIH-AARP diet and health study. AN - 70360584; 17416763 AB - Obesity and menopausal estrogen therapy are established risk factors for endometrial cancer. However, the joint effects of obesity and menopausal hormone therapy on endometrial cancer risk are incompletely understood. We addressed this issue in a cohort of 103,882 women ages 50 to 71 years at baseline in 1995 to 1996. During a median of 4.6 years, which contributed to a total of 455,304 person-years of follow-up through 2000, 677 cases of endometrial cancer were ascertained. Both baseline body mass index (BMI) and adult weight gain were associated with increased endometrial cancer risk. The multivariate relative risk (RR) comparing obese with normal weight women (BMI >30 versus or=20 kg had a RR of 2.75 (95% CI, 1.96-3.86). Menopausal hormone therapy significantly modified the relations of BMI (P(interaction) or=20 kg among never users and ever users of menopausal hormone therapy were 5.35 (95% CI, 3.01-9.52) and 1.43 (95% CI, 0.96-2.15), respectively. We conclude that both current adiposity and adult weight gain are associated with substantial increases in the risk of endometrial cancer, with relations particularly evident among never users of menopausal hormone therapy. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Chang, Shih-Chen AU - Lacey, James V AU - Brinton, Louise A AU - Hartge, Patricia AU - Adams, Kenneth AU - Mouw, Traci AU - Carroll, Leslie AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Leitzmann, Michael F AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Suite 320, Executive Plaza South, MSC7232, Bethesda, MD 20892-7232, USA. Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 723 EP - 730 VL - 16 IS - 4 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - Nutritional Status KW - Prospective Studies KW - Risk Factors KW - Humans KW - Surveys and Questionnaires KW - Aged KW - Middle Aged KW - Body Mass Index KW - United States -- epidemiology KW - Female KW - Risk Assessment KW - Body Weight KW - Estrogen Replacement Therapy -- adverse effects KW - Endometrial Neoplasms -- epidemiology KW - Obesity -- epidemiology KW - Menopause KW - Endometrial Neoplasms -- etiology KW - Obesity -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70360584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Lifetime+weight+history+and+endometrial+cancer+risk+by+type+of+menopausal+hormone+use+in+the+NIH-AARP+diet+and+health+study.&rft.au=Chang%2C+Shih-Chen%3BLacey%2C+James+V%3BBrinton%2C+Louise+A%3BHartge%2C+Patricia%3BAdams%2C+Kenneth%3BMouw%2C+Traci%3BCarroll%2C+Leslie%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BLeitzmann%2C+Michael+F&rft.aulast=Chang&rft.aufirst=Shih-Chen&rft.date=2007-04-01&rft.volume=16&rft.issue=4&rft.spage=723&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-05 N1 - Date created - 2007-04-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pregnane X receptor activation ameliorates DSS-induced inflammatory bowel disease via inhibition of NF-kappaB target gene expression. AN - 70348401; 17170021 AB - Pregnane X receptor (PXR) expression was shown to be protective in inflammatory bowel disease (IBD). However, the mechanism by which PXR provides protection remains unclear. Wild-type and Pxr-null mice were treated with the PXR agonist pregnenolone-16alpha-carbonitrile or vehicle and administered 2.5% dextran sulfate sodium (DSS) in drinking water to induce IBD. Typical clinical symptoms were evaluated on a daily basis. In vivo intestinal permeability assays and proinflammatory cytokine analysis were performed. PXR agonist-treated mice were protected from DSS-induced colitis compared with vehicle-treated mice, as defined by body weight loss, diarrhea, rectal bleeding, colon length, and histology. Pregnenolone-16alpha-carbonitrile did not decrease the severity of IBD in Pxr-null mice. PXR agonist treatment did not increase epithelial barrier function but did decrease mRNA expression of several NF-kappaB target genes in a PXR-dependent manner. The present study clearly demonstrates a protective role for PXR agonist in DSS-induced IBD. The data suggest that PXR-mediated repression of NF-kappaB target genes in the colon is a critical mechanism by which PXR activation decreases the susceptibility of mice to DSS-induced IBD. JF - American journal of physiology. Gastrointestinal and liver physiology AU - Shah, Yatrik M AU - Ma, Xiaochao AU - Morimura, Keiichirou AU - Kim, Insook AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Center of Cancer Research, National Cancer Institute, National Institutes of health, Bldg. 37, Rm. 3106, Bethesda, MD 20892, USA. Y1 - 2007/04// PY - 2007 DA - April 2007 SP - G1114 EP - G1122 VL - 292 IS - 4 SN - 0193-1857, 0193-1857 KW - Cytokines KW - 0 KW - Gastrointestinal Agents KW - NF-kappa B KW - RNA, Messenger KW - Receptors, Steroid KW - Repressor Proteins KW - pregnane X receptor KW - Pregnenolone Carbonitrile KW - 1434-54-4 KW - Dextran Sulfate KW - 9042-14-2 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Index Medicus KW - Severity of Illness Index KW - Gene Expression -- drug effects KW - Animals KW - Cytokines -- genetics KW - Repressor Proteins -- agonists KW - Colon -- pathology KW - Humans KW - Repressor Proteins -- metabolism KW - Colon -- drug effects KW - Disease Models, Animal KW - Mice KW - Glutathione Transferase -- genetics KW - Cytokines -- metabolism KW - HCT116 Cells KW - Cytoprotection -- drug effects KW - Mice, Knockout KW - RNA, Messenger -- metabolism KW - Transfection KW - Colon -- metabolism KW - Glutathione Transferase -- biosynthesis KW - Mice, Inbred C57BL KW - ATP-Binding Cassette Transporters -- biosynthesis KW - ATP-Binding Cassette Transporters -- genetics KW - Time Factors KW - Receptors, Steroid -- deficiency KW - Colitis -- genetics KW - Inflammatory Bowel Diseases -- chemically induced KW - Colitis -- metabolism KW - Inflammatory Bowel Diseases -- prevention & control KW - NF-kappa B -- genetics KW - Colitis -- prevention & control KW - Pregnenolone Carbonitrile -- therapeutic use KW - Gastrointestinal Agents -- pharmacology KW - Inflammatory Bowel Diseases -- metabolism KW - Receptors, Steroid -- metabolism KW - Colitis -- chemically induced KW - Receptors, Steroid -- genetics KW - Gastrointestinal Agents -- therapeutic use KW - Receptors, Steroid -- agonists KW - Pregnenolone Carbonitrile -- pharmacology KW - NF-kappa B -- metabolism KW - Inflammatory Bowel Diseases -- genetics KW - NF-kappa B -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70348401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Gastrointestinal+and+liver+physiology&rft.atitle=Pregnane+X+receptor+activation+ameliorates+DSS-induced+inflammatory+bowel+disease+via+inhibition+of+NF-kappaB+target+gene+expression.&rft.au=Shah%2C+Yatrik+M%3BMa%2C+Xiaochao%3BMorimura%2C+Keiichirou%3BKim%2C+Insook%3BGonzalez%2C+Frank+J&rft.aulast=Shah&rft.aufirst=Yatrik&rft.date=2007-04-01&rft.volume=292&rft.issue=4&rft.spage=G1114&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Gastrointestinal+and+liver+physiology&rft.issn=01931857&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-17 N1 - Date created - 2007-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Amelioration of benzo (a) pyrene-induced lung carcinogenesis in strain A mice by diphenylmethyl selenocyanate. AN - 70342930; 17178216 AB - Organoselenocyanates are an important class of chemopreventive agents, which possess antioxidative, antimutagenic and anticarcinogenic properties. In the present study, we used benzo (a) pyrene (BP)-induced lung carcinogenesis model for assessment of the chemopreventive efficacy of diphenylmethyl selenocyanate, a synthetic organoselenocyanate. BP was given at a dose of 0.2mg/mouse to initiate lung carcinogenesis in strain A mouse and the Se compound was given orally at a dose of 3mg/kgb.w. Histopathological characterizations and biochemical estimation were done to determine the protective effect of Se compound during the progression of lung carcinogenesis. Hyperplasia and severe dysplasia, the precancerous stage, were evident in carcinogen control group after 8th and 22nd week, respectively. These times were selected as the targets for chemoprevention. Treatment with the Se compound effectively reduced the incidence of hyperplasia and severe dysplasia. The Se compound also significantly (p<0.01) reduced microsomal lipid peroxidation and induced glutathione-S-transferase activity in liver and lung when measured after 8th and 22nd week. Lung cancer is diagnosed in majority of cases only at a later stage. These findings will further strengthen the view on organoselenocyanate as an effective cancer chemopreventive agent against lung carcinogenesis when applied at the post-initiation phase. JF - Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie AU - Das, Rajat K AU - Banerjee, Sarmistha AU - Bhattacharya, Sudin AD - Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700 026, India. Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 351 EP - 360 VL - 58 IS - 5 SN - 0940-2993, 0940-2993 KW - Anticarcinogenic Agents KW - 0 KW - Organoselenium Compounds KW - diphenylmethyl selenocyanate KW - Benzo(a)pyrene KW - 3417WMA06D KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Glutathione Transferase -- metabolism KW - Body Weight -- drug effects KW - Lipid Peroxidation -- drug effects KW - Mice KW - Male KW - Female KW - Lung Neoplasms -- prevention & control KW - Organoselenium Compounds -- therapeutic use KW - Anticarcinogenic Agents -- therapeutic use KW - Benzo(a)pyrene -- toxicity KW - Lung -- drug effects KW - Lung Neoplasms -- chemically induced KW - Lung -- pathology KW - Lung -- metabolism KW - Lung Neoplasms -- pathology KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70342930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+toxicologic+pathology+%3A+official+journal+of+the+Gesellschaft+fur+Toxikologische+Pathologie&rft.atitle=Amelioration+of+benzo+%28a%29+pyrene-induced+lung+carcinogenesis+in+strain+A+mice+by+diphenylmethyl+selenocyanate.&rft.au=Das%2C+Rajat+K%3BBanerjee%2C+Sarmistha%3BBhattacharya%2C+Sudin&rft.aulast=Das&rft.aufirst=Rajat&rft.date=2007-04-01&rft.volume=58&rft.issue=5&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=Experimental+and+toxicologic+pathology+%3A+official+journal+of+the+Gesellschaft+fur+Toxikologische+Pathologie&rft.issn=09402993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-30 N1 - Date created - 2007-04-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Management of hepatitis B: summary of a clinical research workshop. AN - 70332989; 17393513 AB - Chronic hepatitis B is caused by persistent infection with the hepatitis B virus (HBV), a unique DNA virus that replicates through an RNA intermediate produced from a stable covalently closed circular DNA molecule. Viral persistence appears to be due to inadequate innate and adaptive immune responses. Chronic infection has a variable course after several decades resulting in cirrhosis in up to one-third of patients and liver cancer in a proportion of those with cirrhosis. Sensitive assays for HBV DNA levels in serum have been developed that provide important insights into pathogenesis and natural history. Therapy of hepatitis B is evolving. Peginterferon induces long-term remissions in disease in one-third of patients with typical hepatitis B e antigen (HBeAg) positive chronic hepatitis B, but a lesser proportion of those without HBeAg. Several oral nucleoside analogues with activity against HBV have been shown to be effective in suppressing viral levels and improving biochemical and histological features of disease in a high proportion of patients with and without HBeAg, at least in the short term. What is uncertain is which agent or combination of agents is most effective, how long therapy should last, and which criteria should be used to start, continue, switch or stop therapy. Long-term therapy with nucleoside analogues may be the most appropriate approach to treatment, but the expense and lack of data on long-term safety and efficacy make recommendations difficult. Clearly, many basic and clinical research challenges remain in defining optimal means of management of chronic hepatitis B. JF - Hepatology (Baltimore, Md.) AU - Hoofnagle, Jay H AU - Doo, Edward AU - Liang, T Jake AU - Fleischer, Russell AU - Lok, Anna S F AD - Liver Disease Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. HoofnagleJ@extra.niddk.nih.gov Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 1056 EP - 1075 VL - 45 IS - 4 SN - 0270-9139, 0270-9139 KW - Antiviral Agents KW - 0 KW - Index Medicus KW - Drug Therapy, Combination KW - Humans KW - Hepatitis B virus -- physiology KW - Drug Resistance, Viral -- physiology KW - Female KW - Pregnancy KW - Hepatitis B, Chronic -- etiology KW - Antiviral Agents -- therapeutic use KW - Antiviral Agents -- economics KW - Antiviral Agents -- adverse effects KW - Hepatitis B, Chronic -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70332989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Serotonergic+responsiveness+in+human+cocaine+users.&rft.au=Ghitza%2C+Udi+E%3BRothman%2C+Richard+B%3BGorelick%2C+David+A%3BHenningfield%2C+Jack+E%3BBaumann%2C+Michael+H&rft.aulast=Ghitza&rft.aufirst=Udi&rft.date=2007-01-12&rft.volume=86&rft.issue=2-3&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-29 N1 - Date created - 2007-04-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transcriptional bypass of bulky DNA lesions causes new mutant RNA transcripts in human cells. AN - 70332660; 17363972 AB - Here, we characterize the mutant transcripts resulting from bypass of an 8,5'-cyclo-2'-deoxyadenosine (cyclo-dA) or cyclobutane pyrimidine dimer (CPD) by human RNA polymerase II (Pol II) in vivo. With the cyclo-dA lesion, we observed two new types of mutant transcripts. In the first type, the polymerase inserted uridine opposite the lesion and then misincorporated adenosine opposite the template deoxyadenosine downstream (5') of the lesion. The second type contained deletions of 7, 13 or 21 nucleotides (nt) after uridine incorporation opposite the lesion. The frequency of the different types of transcript from the cyclo-dA lesion in mutant human cell lines suggests that the Cockayne syndrome B protein affects the probability of deletion transcript formation. With the CPD-containing construct, we also detected rare transcripts containing 12 nt deletions. These results indicate that RNA pol II in living human cells can bypass helix-distorting DNA lesions that are substrates for nucleotide excision repair, resulting in transcriptional mutagenesis. JF - EMBO reports AU - Marietta, Cheryl AU - Brooks, Philip J AD - Section on Molecular Neurobiology, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, 5625 Fishers Lane, Room 3S-32, MSC 9412, Bethesda, Maryland 20892, USA. Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 388 EP - 393 VL - 8 IS - 4 SN - 1469-221X, 1469-221X KW - Deoxyadenosines KW - 0 KW - Pyrimidine Dimers KW - 8,5'-cyclo-2'-deoxyadenosine KW - 117182-88-4 KW - RNA Polymerase II KW - EC 2.7.7.- KW - Index Medicus KW - Base Sequence KW - DNA Repair KW - Pyrimidine Dimers -- metabolism KW - Cells, Cultured KW - Humans KW - Deoxyadenosines -- metabolism KW - Mutation KW - RNA Polymerase II -- physiology KW - DNA Damage KW - Mutagenesis -- genetics KW - Transcription, Genetic -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70332660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EMBO+reports&rft.atitle=Transcriptional+bypass+of+bulky+DNA+lesions+causes+new+mutant+RNA+transcripts+in+human+cells.&rft.au=Marietta%2C+Cheryl%3BBrooks%2C+Philip+J&rft.aulast=Marietta&rft.aufirst=Cheryl&rft.date=2007-04-01&rft.volume=8&rft.issue=4&rft.spage=388&rft.isbn=&rft.btitle=&rft.title=EMBO+reports&rft.issn=1469221X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-30 N1 - Date created - 2007-04-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mutat Res. 2002 Dec 29;510(1-2):131-40 [12459449] EMBO J. 2002 Jan 15;21(1-2):157-64 [11782435] DNA Repair (Amst). 2002 Nov 3;1(11):967-75 [12531024] J Biol Chem. 2003 Sep 12;278(37):35597-608 [12813036] Proc Natl Acad Sci U S A. 1975 Jan;72(1):59-63 [164028] Proc Natl Acad Sci U S A. 1986 Nov;83(21):8273-7 [3464953] Biochemistry. 1988 Aug 9;27(16):6008-13 [2847780] Nature. 1993 Nov 4;366(6450):33-9 [8232535] Cell. 1995 Aug 25;82(4):577-85 [7664337] Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11205-9 [9326587] J Biol Chem. 1998 May 22;273(21):13170-6 [9582358] Carcinogenesis. 1999 Mar;20(3):395-9 [10190552] Mol Cell. 2005 May 13;18(4):461-70 [15893729] Mol Cell. 2005 May 27;18(5):499-505 [15916957] Mutat Res. 2005 Sep 4;577(1-2):155-61 [15913669] Mutat Res. 2005 Sep 4;577(1-2):179-94 [16009385] Mol Cell. 2005 Oct 28;20(2):187-98 [16246722] EMBO J. 2006 Jan 25;25(2):387-97 [16407975] Science. 2006 Nov 17;314(5802):1144-7 [17110578] Science. 2007 Feb 9;315(5813):859-62 [17290000] J Biol Chem. 2000 Jul 21;275(29):22355-62 [10801836] Science. 2001 Jun 8;292(5523):1876-82 [11313499] J Biol Chem. 2001 Dec 28;276(52):49283-8 [11677235] J Cell Sci. 2003 Feb 1;116(Pt 3):447-51 [12508106] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma. AN - 70323470; 17071630 AB - The caspase proteins are essential for the regulation of normal B cell development and regulation of apoptosis. We investigated five single nucleotide polymorphisms in four key caspase genes, CASP3 [Ex8-280C>A (rs6948) and Ex8+567T>C (rs1049216)], CASP8 Ex14-271A>T (rs13113), CASP9 Ex5+32G>A (rs1052576) and CASP10 Ex3-171A>G (rs3900115) to determine whether they alter risk for non-Hodgkin lymphoma (NHL) in a population-based case-control study of women in Connecticut (461 cases and 535 controls). Variants in CASP3 and CASP9 were significantly associated with a decreased risk for NHL, particularly follicular lymphoma [e.g. CASP3 Ex8+567T>C odds ratio (OR)(CC+TC) = 0.4, 95% confidence interval (CI) = 0.3-0.7; and CASP9 Ex5+32G>A OR(AA+AG) = 0.6, 95% CI = 0.4-1.0]. Further, variants in CASP3, CASP8 and CASP10 were associated with a decreased risk of marginal zone lymphoma and variants in CASP3 and CASP10 were associated with a lower risk of chronic lymphocytic leukemia and related subtypes. The striking protective associations observed for polymorphisms in all four genes for NHL and/or one or more subtypes suggest that genetic variation in CASP genes may play an important role in the etiology of NHL. JF - Carcinogenesis AU - Lan, Qing AU - Zheng, Tongzhang AU - Chanock, Stephen AU - Zhang, Yawei AU - Shen, Min AU - Wang, Sophia S AU - Berndt, Sonja I AU - Zahm, Shelia H AU - Holford, Theodore R AU - Leaderer, Brian AU - Yeager, Meredith AU - Welch, Robert AU - Hosgood, Dean AU - Boyle, Peter AU - Rothman, Nathaniel AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute NIH, DHHS, Bethesda, MD 20892-7240, USA. qingl@mail.nih.gov Y1 - 2007/04// PY - 2007 DA - April 2007 SP - 823 EP - 827 VL - 28 IS - 4 SN - 0143-3334, 0143-3334 KW - CASP3 protein, human KW - EC 3.4.22.- KW - CASP8 protein, human KW - CASP9 protein, human KW - Caspase 10 KW - Caspase 3 KW - Caspase 8 KW - Caspase 9 KW - CASP10 protein, human KW - EC 3.4.22.63 KW - Index Medicus KW - Genetic Variation KW - DNA Repair KW - Aged, 80 and over KW - Risk Factors KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Female KW - Lymphoma, Non-Hodgkin -- genetics KW - Caspase 3 -- genetics KW - Polymorphism, Single Nucleotide KW - Caspase 9 -- genetics KW - Caspase 8 -- genetics KW - Genetic Predisposition to Disease KW - Caspase 10 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70323470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Genetic+variants+in+caspase+genes+and+susceptibility+to+non-Hodgkin+lymphoma.&rft.au=Lan%2C+Qing%3BZheng%2C+Tongzhang%3BChanock%2C+Stephen%3BZhang%2C+Yawei%3BShen%2C+Min%3BWang%2C+Sophia+S%3BBerndt%2C+Sonja+I%3BZahm%2C+Shelia+H%3BHolford%2C+Theodore+R%3BLeaderer%2C+Brian%3BYeager%2C+Meredith%3BWelch%2C+Robert%3BHosgood%2C+Dean%3BBoyle%2C+Peter%3BRothman%2C+Nathaniel&rft.aulast=Lan&rft.aufirst=Qing&rft.date=2007-04-01&rft.volume=28&rft.issue=4&rft.spage=823&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-10 N1 - Date created - 2007-03-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A phase II and pharmacodynamic study of gefitinib in patients with refractory or recurrent epithelial ovarian cancer. AN - 70323382; 17330838 AB - The primary objective of this study was to evaluate the biochemical effects of gefitinib on its target signal-transduction pathways in patients with recurrent epithelial ovarian cancer (EOC). The secondary objectives included assessing clinical activity and toxicity and determining the association between biochemical and clinical outcomes. Twenty-four heavily pretreated patients with EOC who had good end-organ function and performance status and who had measurable disease received gefitinib 500 mg daily. Prospectively planned core-needle tumor biopsies were obtained before treatment and after 4 weeks. Protein expression of total and phosphorylated (p) epidermal growth factor receptor (EGFR), protein kinase B (AKT), and extracellular regulated kinase (ERK) was quantified in microdissected tumor cells using tissue lysate array proteomics. All tumor samples had detectable levels of EGFR and p-EGFR. A decrease in the quantity of both EGFR and p-EGFR was observed with gefitinib therapy in >50% of patients. This was not associated with clinical benefit, nor were responses observed. However, trends for increased gastrointestinal and skin toxicity were observed with greater phosphorylation or quantities of EGFR, ERK, and AKT in tumor samples (P 5 standard drinks on drinking days), and nonhazardous drinkers (consume <5 standard drinks on drinking days). Our results showed that nonhazardous alcohol consumption decreased survival by more than 1 year if the frequency of consumption was once per week or greater, and by 3.3 years (from 21.7 years to 18.4 years) with daily consumption. Hazardous alcohol consumption decreased overall survival by more than 3 years if frequency of consumption was once per week or greater, and by 6.4 years (from 16.1 years to 9.7 years) with daily consumption. Our results suggest that alcohol is an underappreciated yet modifiable risk factor for poor survival among individuals with HIV. Reprinted by permission of Routledge, Taylor & Francis Ltd. JF - AIDS care AU - Braithwaite, R S AU - Conigliaro, J AU - Roberts, M S AU - Shechter, S AU - Schaefer, A AU - McGinnis, K AU - Rodriguez, M C AU - Rabeneck, L AU - Bryant, K AU - Justice, A C AD - Yale University ; University of Pittsburgh ; Houston Veterans Administration Medical Center ; University of Toronto ; National Institutes of Health, Bethesda Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 459 EP - 466 VL - 19 IS - 4 SN - 0954-0121, 0954-0121 KW - Sociology KW - Risk KW - Alcohol KW - Drinks KW - Consumption KW - Cross-sectional analysis KW - Diseases KW - Data analysis KW - HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36753284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+care&rft.atitle=Estimating+the+impact+of+alcohol+consumption+on+survival+for+HIV+%2B+individuals&rft.au=Braithwaite%2C+R+S%3BConigliaro%2C+J%3BRoberts%2C+M+S%3BShechter%2C+S%3BSchaefer%2C+A%3BMcGinnis%2C+K%3BRodriguez%2C+M+C%3BRabeneck%2C+L%3BBryant%2C+K%3BJustice%2C+A+C&rft.aulast=Braithwaite&rft.aufirst=R&rft.date=2007-04-01&rft.volume=19&rft.issue=4&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=AIDS+care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540120601095734 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 909; 2805 3872 554 971; 5703 3617 6220; 3617 6220; 11035; 3063 971; 3279 971 3286; 3737 DO - http://dx.doi.org/10.1080/09540120601095734 ER - TY - JOUR T1 - Survey of environmental enhancement programs for laboratory primates AN - 36743341; 3466068 AB - Animal welfare regulations in the United States require that nonhuman primate environmental enhancement plans be made in accordance with currently accepted professional standards; however, little information is available for quantifying common practice. Here we report the results of a 2003 survey that was sent to individuals overseeing enrichment programs at a variety of primate research institutions. The surveys requested information on program administration and management, implementation standards, procedures, and constraints pertaining to major categories of environmental enrichment, as well as intervention plans for animals exhibiting behavioral pathologies. Data were obtained on the management of 35,863 primates in 22 facilities. Behavioral scientists performed program oversight at the majority of facilities. Most programs reported recent changes, most commonly due to external site visits, and least commonly resulting from internal review. Most facilities' institutional animal care and use committees (LACUCs) included of individuals with behavioral expertise, and about two-thirds reported that enrichment issues could influence research protocol design. While most primates were reported to be housed socially (73%), social housing for indoor-housed primates appears to have changed little over the past 10 years. Research protocol issues and social incompatibility were commonly cited constraints. Implementation of feeding, manipulanda, and structural enrichment was relatively unconstrained, and contributions to these aspects of behavioral management generally included individuals in a wide variety of positions within a facility. In contrast, enrichment devices were used on a less widespread basis within facilities, and positive reinforcement programs that involved dedicated trainers were rare. We suggest that altering the role of the LACUC would be a productive avenue for increasing the implementation of social housing, and that an emphasis on prevention rather than intervention against behavioral pathology is warranted. The data from this survey may be useful for anticipating future program evaluations, establishing more effective internal evaluations, and assessing program progress and resource allocation. Copyright John Wiley & Sons. Reproduced with permission. An electronic version of this article is available online at http://www.interscience.wiley.com JF - American journal of primatology AU - Baker, Kate C AU - Weed, James L AU - Crockett, Carolyn M AU - Bloomsmith, Mollie A AD - Tulane National Primate Research Center ; National Institutes of Health, Bethesda ; Washington National Primate Research Center ; Yerkes National Primate Research Center Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 377 EP - 394 VL - 69 IS - 4 SN - 0275-2565, 0275-2565 KW - Anthropology KW - Environment KW - Feeding KW - Primatology KW - Well-being KW - Laboratory KW - Regulation KW - U.S.A. KW - Primates KW - Behavioural sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36743341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+primatology&rft.atitle=Survey+of+environmental+enhancement+programs+for+laboratory+primates&rft.au=Baker%2C+Kate+C%3BWeed%2C+James+L%3BCrockett%2C+Carolyn+M%3BBloomsmith%2C+Mollie+A&rft.aulast=Baker&rft.aufirst=Kate&rft.date=2007-04-01&rft.volume=69&rft.issue=4&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=American+journal+of+primatology&rft.issn=02752565&rft_id=info:doi/10.1002%2Fajp.20347 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 10148; 7127 13673 4214; 4309; 1542 11325; 4853 5114; 13530 13521; 10742; 10149; 433 293 14 DO - http://dx.doi.org/10.1002/ajp.20347 ER - TY - JOUR T1 - Approaches to the development of medications for the treatment of methamphetamine dependence AN - 36662045; 3422315 AB - Background Methamphetamine abuse has become an increasing problem in both the United States and globally with concomitant increases in adverse medical, social and environmental sequelae. Behavioral therapies have been used with some success to treat methamphetamine abusers and dependent individuals, but are not universally efficacious. Methamphetamine has a rich pharmacology that theoretically provides many opportunities for potential pharmacotherapeutic intervention. Nevertheless, there are no approved medications with an indication for treating methamphetamine abusers or addicts at this time. Aim To describe briefly how methamphetamine functions and affects function in brain and report how basic researchers and clinicians are attempting to exploit and exploiting this knowledge to discover and develop effective pharmacotherapies. Results Scientifically based approaches to medications development by evaluating medications that limit brain exposure to methamphetamine: modulate methamphetamine effects at vesicular monoamine transporter-2 (VMAT-2); or affect dopaminergic, serotonergic. GABAergic, and/or glutamatergic brain pathways that participate in methamphetamine's reinforcing effects are presented. Conclusion The evidence supports the rationale that pharmacotherapies to decrease methamphetamine use, or reduce craving during abstinence may be developed from altering the pharmacokinetics and pharmacodynamics of methamphetamine or its effects on appetitive systems in the brain. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Vocci, Frank J AU - Appel, Nathan M AD - National Institutes of Health Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 96 EP - 106 VL - 102 IS - Supp.1 SN - 0965-2140, 0965-2140 KW - Sociology KW - Methamphetamine KW - Neuropsychology KW - Health care KW - Medical research KW - Social problems KW - Medical treatment KW - Neuroscience KW - Drug addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36662045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Approaches+to+the+development+of+medications+for+the+treatment+of+methamphetamine+dependence&rft.au=Vocci%2C+Frank+J%3BAppel%2C+Nathan+M&rft.aulast=Vocci&rft.aufirst=Frank&rft.date=2007-04-01&rft.volume=102&rft.issue=Supp.1&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 3744 561 6220; 5775 13521; 8637; 8636; 7886 10902; 7890 5792 10484; 11893 11979 ER - TY - JOUR T1 - The NIDA methamphetamine clinical trials group: a strategy to increase clinical trials research capacity AN - 36661940; 3422316 AB - Aims In order to increase the number of investigative teams and sites conducting research on pharmacological treatments for methamphetamine use disorders, the National Institute on Drug Abuse (NIDA) established an infrastructure of clinical sites in areas where methamphetamine addiction is prevalent. This multi-site infrastructure would serve to run multiple Phases II and III protocols effectively and expeditiously. Methods NIDA collaborated with investigators from the University of California at Los Angeles (UCLA) to set up the Methamphetamine Clinical Trials Group (MCTG). This paper describes the development process, as well as data from a test trial to assess the capability of research-naive sites to recruit research participants and conduct study procedures according to research protocol. Subsequently trials are also described. Results A total 151 candidates signed consent; 65 individuals were enrolled and 35 (53.8%) completed the 12 weeks' behavioral trial. Self-reported substance use report (SUR) showed comparable use of methamphetamine across sites with the individual site means ranging from 59% (site 5) to 80% (site 3). Drug use as measured by urinalysis was greatly reduced at week 13 compared to the baseline measure; the average rate of methamphetamine-free urine samples across all participants in sites at week 13 was 53%. The highest percentage of methamphetamine-free samples was 85% at site 5; the lowest was at site 1 (40%). Addiction severity index (ASI) composite scores at baseline and protocol completion for all participants demonstrated improvements in all categories over time, except for the medical composite score. The largest composite score reduction in baseline-protocol completion was in the drug domain (0.23 versus 0.15). The changes in the ASI scores from baseline to week 13 were consistent across all five sites. Conclusions Outcomes of the behavioral trial indicated that the MCTG recruited well: collected study data accurately and reliably; and created a vehicle that can assess promising pharmacotherapies for methamphetamine addiction treatment medications. The MCTG strategy appears to be a feasible approach to increase NIDA's capacity to conduct clinical trials to evaluate potential pharmacotherapies for methamphetamine addiction. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Elkashef, Ahmed AU - Rawson, Richard A AU - Smith, Edwina AU - Pearce, Valerie AU - Flammino, Frank AU - Campbell, Jan AU - Donovick, Roger AU - Gorodetzky, Charles AU - Haning, William AU - Mawhinney, Joseph AU - McCann, Michael AU - Weis, Dennis AU - Williams, Lorie AU - Ling, Walter AU - Vocci, Frank AD - National Institutes of Health ; University of California, Los Angeles ; New York University ; University of Missouri, Kansas City ; Matrix Institute on Addictions, California ; Quintiles, Inc., Kansas City ; John A. Burns School of Medicine, Honolulu ; South Bay Treatment Center, San Diego ; Matrix Institute on Addictions, West Los Angeles ; Lutheran Hospital, Des Moines ; Southwest Kidney Institute PLC Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 107 EP - 113 VL - 102 IS - Supp.1 SN - 0965-2140, 0965-2140 KW - Sociology KW - Clinical trials KW - Methamphetamine KW - Health care KW - Medical research KW - Social problems KW - Drug addiction KW - Developmental psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36661940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=The+NIDA+methamphetamine+clinical+trials+group%3A+a+strategy+to+increase+clinical+trials+research+capacity&rft.au=Elkashef%2C+Ahmed%3BRawson%2C+Richard+A%3BSmith%2C+Edwina%3BPearce%2C+Valerie%3BFlammino%2C+Frank%3BCampbell%2C+Jan%3BDonovick%2C+Roger%3BGorodetzky%2C+Charles%3BHaning%2C+William%3BMawhinney%2C+Joseph%3BMcCann%2C+Michael%3BWeis%2C+Dennis%3BWilliams%2C+Lorie%3BLing%2C+Walter%3BVocci%2C+Frank&rft.aulast=Elkashef&rft.aufirst=Ahmed&rft.date=2007-04-01&rft.volume=102&rft.issue=Supp.1&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 3744 561 6220; 7886 10902; 3518 10404; 5775 13521; 11893 11979 ER - TY - JOUR T1 - Structural and metabolic brain changes in the striatum associated with methamphetamine abuse AN - 36660877; 3422307 AB - Aims To review structural, chemical and metabolic brain changes, particularly those in the basal ganglia, in individuals who used methamphetamine, as well as in children with prenatal methamphetamine exposure. Methods Magnetic resonance imaging (MRI) and positron emission tomography (PET) studies that evaluated brain structural, chemical and metabolite changes in methamphetamine subjects, or children with prenatal methamphetamine exposure, were reviewed and summarized. Relevant pre-clinical studies that provided insights to the interpretations of these imaging studies were also reviewed. Results In adults who used methamphetamine, MRI demonstrates enlarged striatal volumes, while MR spectroscopy shows reduced concentrations of the neuronal marker N-acetylasparate and total creatine in the basal ganglia. In contrast, children with prenatal methamphetamine exposure show smaller striatal structures and elevated total creatine. Furthermore, PET studies consistently showed reduced dopamine transporter (DAT) density and reduced dopamine D2 receptors in the striatum of methamphetamine subjects. PET studies also found lower levels of serotonergic transporter density and vesicular monoamine transporter (VMAT2) across striatal subregions, as well as altered brain glucose metabolism that correlated with severity of psychiatric symptoms in the limbic and orbitofrontal regions. Conclusion Neuroimaging studies demonstrate abnormalities in brain structure and chemistry convincingly in individuals who used methamphethamine and in children with prenatal methamphetamine exposure, especially in the striatum. However, many important questions remain and larger sample sizes are needed to validate these preliminary observations. Furthermore, longitudinal studies are needed to evaluate the effects of treatment and abstinence on these brain changes and to determine whether imaging, and possibly genetic, markers can be used to predict treatment outcome or relapse. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Chang, Linda AU - Alicata, Daniel AU - Ernst, Thomas AU - Volkow, Nora AD - University of Hawaii ; National Institutes of Health, Rockville Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 16 EP - 32 VL - 102 IS - Supp.1 SN - 0965-2140, 0965-2140 KW - Sociology KW - Methamphetamine KW - Neuropsychology KW - Health care KW - Medical research KW - Brain KW - Social problems KW - Drug addiction KW - Developmental psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36660877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Structural+and+metabolic+brain+changes+in+the+striatum+associated+with+methamphetamine+abuse&rft.au=Chang%2C+Linda%3BAlicata%2C+Daniel%3BErnst%2C+Thomas%3BVolkow%2C+Nora&rft.aulast=Chang&rft.aufirst=Linda&rft.date=2007-04-01&rft.volume=102&rft.issue=Supp.1&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 3744 561 6220; 5775 13521; 1750 1678; 8636; 7886 10902; 3518 10404; 11893 11979 ER - TY - JOUR T1 - New information on methamphetamine AN - 36660337; 3422630 JF - Addiction AU - Rawson, Richard A AU - Condon, Timothy P AU - Baicy, Kate AU - London, Edythe D AU - Chang, Linda AU - Alicata, Daniel AU - Ernst, Thomas AU - Volkow, Nora AU - Aron, Jennifer L AU - Paulus, Martin P AU - Volz, Trent J AU - Fleckenstein, Annette E AU - Hanson, Glen R AU - Tata, Despina A AU - Yamamoto, Bryan K AU - Marshall, John F AU - Belcher, Annabelle M AU - Feinstein, Erin M AU - O'Dell, Steven J AU - Haning, William AU - Goebert, Deborah AU - Halkitis, Perry N AU - Mukherjee, Preetika Pandey AU - Palamar, Joseph J AU - Hillhouse, Maureen P AU - Marinelli-Casey, Patricia AU - Gonzales, Rachel AU - Ang, Alfonso AU - Vocci, Frank J AU - Appel, Nathan M AU - Elkashef, Ahmed AU - Smith, Edwina AU - Pearce, Valerie AU - Flammino, Frank AU - Campbell, Jan AU - Donovick, Roger AU - Gorodetzky, Charles AU - Mawhinney, Joseph AU - McCann, Michael AU - Weis, Dennis AU - Williams, Lorie AU - Ling, Walter AU - Vocci, Frank AU - Roll, John M AU - Donovan, Dennis M AU - Wells, Elizabeth A AU - Shoptaw, Steven AU - Reback, Cathy J AD - National Institure of Health, Bethesda ; University of California, Los Angeles ; University of Hawaii ; National Institutes of Health, Rockville ; University of California, San Diego ; University of Utah ; Boston University ; University of California, Irvine ; New York University ; National Institutes of Health ; University of Missouri, Kansas City ; Matrix Institute on Addictions, California ; Quintiles, Inc., Kansas City ; South Bay Treatment Center, San Diego ; Matrix Institute on Addictions, West Los Angeles ; Lutheran Hospital, Des Moines ; Southwest Kidney Institute PLC ; Washington State University ; University of Washington Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 1 EP - 135 VL - 102 IS - Supp.1 SN - 0965-2140, 0965-2140 KW - Anthropology KW - Methamphetamine KW - Neuropsychology KW - Dependency rehabilitation KW - Health care KW - Social problems KW - Neuroscience KW - Toxicity KW - Cocaine KW - Drug abuse KW - Drug addiction KW - Developmental psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36660337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=New+information+on+methamphetamine&rft.au=Rawson%2C+Richard+A%3BCondon%2C+Timothy+P%3BBaicy%2C+Kate%3BLondon%2C+Edythe+D%3BChang%2C+Linda%3BAlicata%2C+Daniel%3BErnst%2C+Thomas%3BVolkow%2C+Nora%3BAron%2C+Jennifer+L%3BPaulus%2C+Martin+P%3BVolz%2C+Trent+J%3BFleckenstein%2C+Annette+E%3BHanson%2C+Glen+R%3BTata%2C+Despina+A%3BYamamoto%2C+Bryan+K%3BMarshall%2C+John+F%3BBelcher%2C+Annabelle+M%3BFeinstein%2C+Erin+M%3BO%27Dell%2C+Steven+J%3BHaning%2C+William%3BGoebert%2C+Deborah%3BHalkitis%2C+Perry+N%3BMukherjee%2C+Preetika+Pandey%3BPalamar%2C+Joseph+J%3BHillhouse%2C+Maureen+P%3BMarinelli-Casey%2C+Patricia%3BGonzales%2C+Rachel%3BAng%2C+Alfonso%3BVocci%2C+Frank+J%3BAppel%2C+Nathan+M%3BElkashef%2C+Ahmed%3BSmith%2C+Edwina%3BPearce%2C+Valerie%3BFlammino%2C+Frank%3BCampbell%2C+Jan%3BDonovick%2C+Roger%3BGorodetzky%2C+Charles%3BMawhinney%2C+Joseph%3BMcCann%2C+Michael%3BWeis%2C+Dennis%3BWilliams%2C+Lorie%3BLing%2C+Walter%3BVocci%2C+Frank%3BRoll%2C+John+M%3BDonovan%2C+Dennis+M%3BWells%2C+Elizabeth+A%3BShoptaw%2C+Steven%3BReback%2C+Cathy+J&rft.aulast=Rawson&rft.aufirst=Richard&rft.date=2007-04-01&rft.volume=102&rft.issue=Supp.1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - SuppNotes - Collection of 15 articles N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 3744 561 6220; 12807 9818; 3742 1121 11776 3753 3755; 2435 3755; 5775 13521; 8637; 8636; 3432 12356 12357; 3518 10404; 11893 11979 ER - TY - JOUR T1 - Structural basis for the mechanism of electron bifurcation at the quinol oxidation site of the cytochrome bc sub(1) complex AN - 20986539; 7570609 AB - At the heart of the Q cycle hypothesis, the cytochrome bc sub(1) complex (bc sub(1)) is required to separate the two electrons from a quinol molecule at the quinol oxidation site. Recent studies have brought to light an intricate mechanism for this bifurcated electron transfer. A survey of the protein data bank shows 30 entries for the structures of bc sub(1) and the homologous b sub(6)f complex. These structures provide considerable insights into the structural organization of mitochondrial, bacterial, and plant enzymes. Crystallographic binding studies of bc sub(1) with either quinone reduction (Q sub(N)) and/or quinol oxidation (Q sub(P)) site inhibitors offer atomic details on how these compounds interact with residues at their respective sites. Most importantly, the different locations and apparent flexibility observed in crystals for the extrinsic domain of the iron-sulfur protein (ISP) subunit suggest a mechanism for electron bifurcation at the Q sub(P) site. Analyses of various inhibitor-bound structures revealed two classes of Q sub(P) site inhibitors: Pm inhibitors that promote ISP mobility and Pf inhibitors that favor the fixation of the ISP conformation. Those analyses also shed light on a possible process by which the ISP motion switch is controlled. The first phase reduction of ISP is shown to be comparable to the reduction of the b sub(L) heme by pre-steady state kinetic analysis, whereas the second phase reduction of ISP share similar kinetics with the reduction of the b sub(H) heme. The reduction of cyt c sub(1) is measured much slower, indicating that the reduced ISP remains bound at the Q sub(P) site until the reduced heme b sub(L) is oxidized by the heme b sub(H) and supporting the existence of a control mechanism for the ISP motion switch. JF - Photosynthesis Research AU - Xia, Di AU - Esser, Lothar AU - Yu, Linda AU - Yu, Chang-An AD - National Cancer Institute, National Institutes of Health, NIH, 37 Convent Dr., Building 37, Room 2122C, Bethesda, MD, 20892, USA, dixia@helix.nih.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 17 EP - 34 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 92 IS - 1 SN - 0166-8595, 0166-8595 KW - Microbiology Abstracts B: Bacteriology KW - Photosynthesis KW - Mobility KW - Heme KW - Enzymes KW - Mitochondria KW - Crystals KW - Electron transfer KW - Data banks KW - Protein structure KW - Cytochrome bc1 KW - quinol KW - Kinetics KW - Quinone KW - Oxidation KW - iron-sulfur proteins KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20986539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photosynthesis+Research&rft.atitle=Structural+basis+for+the+mechanism+of+electron+bifurcation+at+the+quinol+oxidation+site+of+the+cytochrome+bc+sub%281%29+complex&rft.au=Xia%2C+Di%3BEsser%2C+Lothar%3BYu%2C+Linda%3BYu%2C+Chang-An&rft.aulast=Xia&rft.aufirst=Di&rft.date=2007-04-01&rft.volume=92&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Photosynthesis+Research&rft.issn=01668595&rft_id=info:doi/10.1007%2Fs11120-007-9155-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heme; Mobility; Photosynthesis; Mitochondria; Enzymes; Crystals; Electron transfer; Protein structure; Data banks; Cytochrome bc1; quinol; Kinetics; Oxidation; Quinone; iron-sulfur proteins DO - http://dx.doi.org/10.1007/s11120-007-9155-3 ER - TY - JOUR T1 - Strategies for improved temporal and spectral resolution in in vivo oximetric imaging using time-domain EPR AN - 20857702; 8368444 AB - A radiofrequency (RF) time-domain electron paramagnetic resonance (EPR) instrument operating at 300, 600, and 750 MHz was used to image tumor hypoxia with high spatial and temporal resolution. A high-speed signal-averaging Peripheral Component Interconnect (PCI) board with flexibility in the input signal level and the number of digitized samples per free induction decay (FID) was incorporated into the receive arm of the spectrometer. This enabled effective and fast averaging of FIDs. Modification of the phase-encoding protocol, and replacement of the General Purpose Interface Bus (GPIB)-based handshake with a PCI-based D/A board for direct control of the gradient amplifier decreased the gradient settling and communication overhead times by nearly two orders of magnitude. Cyclically-ordered phase sequence (CYCLOPS) phase cycling was implemented to correct for pulse imperfections and cancel out unwanted constant signals. These upgrades considerably enhanced the performance of the imager in terms of image collection time, sensitivity, and temporal resolution. We demonstrated this by collecting a large number of 2D images successively and rapidly. The results show that it is feasible to achieve accurate, 2D pO2 maps of tumor hypoxia with 1-mm2 resolution and minimal artifacts using a set of multigradient images within an acceptable measuring time of about 3 s, and 3D maps can be obtained in less than 1 min. Magn Reson Med 57:776-783, 2007. JF - Magnetic Resonance in Medicine AU - Devasahayam, Nallathamby AU - Subramanian, Sankaran AU - Murugesan, Ramachandran AU - Hyodo, Fuminori AU - Matsumoto, Ken-Ichiro AU - Mitchell, James B AU - Krishna, Murali C AD - Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA, murali@helix.nih.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 776 EP - 783 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 57 IS - 4 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - E.S.R. KW - Cyclops KW - Hypoxia KW - Communication KW - N.M.R. KW - Tumors KW - imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20857702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Strategies+for+improved+temporal+and+spectral+resolution+in+in+vivo+oximetric+imaging+using+time-domain+EPR&rft.au=Devasahayam%2C+Nallathamby%3BSubramanian%2C+Sankaran%3BMurugesan%2C+Ramachandran%3BHyodo%2C+Fuminori%3BMatsumoto%2C+Ken-Ichiro%3BMitchell%2C+James+B%3BKrishna%2C+Murali+C&rft.aulast=Devasahayam&rft.aufirst=Nallathamby&rft.date=2007-04-01&rft.volume=57&rft.issue=4&rft.spage=776&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21194 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Cyclops; Hypoxia; Tumors; E.S.R.; N.M.R.; imaging; Communication DO - http://dx.doi.org/10.1002/mrm.21194 ER - TY - JOUR T1 - Spectral near-infrared fluorescence imaging of curved surfaces using projection reconstruction algorithms AN - 20815288; 10921630 AB - In vivo spectral fluorescence imaging has made it possible to non-invasively visualize superficial curved structures as well as structures deep to the skin. However, the defocus created by blurring has been an obstacle to creating anatomically interpretable surface images. Herein we present a methodology to correct for blurring induced by curved structures during spectral fluorescence imaging using signal intensity projection algorithms. In a phantom and an animal model in which the lymphatic system was visualized after the interstitial injection of quantum dots with emission spectra in the near-infrared (NIR) range, the planes of focus were sequentially adjusted to obtain a z-stack of images which contains images acquired from multiple focal points. Maximum, minimum, median and average intensity projections were applied to the resulting images. Using the phantom, the minimum and the median intensity projection images demonstrated improved deblurring whereas during in vivo imaging the median intensity projection images more clearly visualized important structures than did the other projection techniques. Image stacking with subsequent application of appropriate projection techniques provides a simple method for deblurring in vivo optical images obtained from curved surfaces, thus improving their anatomic resolution. JF - Contrast Media and Molecular Imaging AU - Hama, Yukihiro AU - Koyama, Yoshinori AU - Bernardo, Marcelino AU - Choyke, Peter L AU - Kobayashi, Hisataka AD - Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-1088, USA, Kobayash@mail.nih.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 82 EP - 87 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA, [mailto:info@wiley.com], [URL:http://www.wiley.com/WileyCDA/Brand/id-35.html] VL - 2 IS - 2 SN - 1555-4309, 1555-4309 KW - Biotechnology and Bioengineering Abstracts KW - Skin KW - I.R. radiation KW - Fluorescence KW - Quantum dots KW - Stacking KW - Contrast media KW - Animal models KW - Algorithms KW - imaging KW - Lymphatic system KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20815288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contrast+Media+and+Molecular+Imaging&rft.atitle=Spectral+near-infrared+fluorescence+imaging+of+curved+surfaces+using+projection+reconstruction+algorithms&rft.au=Hama%2C+Yukihiro%3BKoyama%2C+Yoshinori%3BBernardo%2C+Marcelino%3BChoyke%2C+Peter+L%3BKobayashi%2C+Hisataka&rft.aulast=Hama&rft.aufirst=Yukihiro&rft.date=2007-04-01&rft.volume=2&rft.issue=2&rft.spage=82&rft.isbn=&rft.btitle=&rft.title=Contrast+Media+and+Molecular+Imaging&rft.issn=15554309&rft_id=info:doi/10.1002%2Fcmmi.129 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - imaging; Fluorescence; Algorithms; I.R. radiation; Lymphatic system; Stacking; Skin; Animal models; Quantum dots; Contrast media DO - http://dx.doi.org/10.1002/cmmi.129 ER - TY - JOUR T1 - Enhanced Antitumor Activity of T Cells Engineered to Express T-Cell Receptors with a Second Disulfide Bond AN - 20797419; 7404865 AB - Adoptive transfer of genetically T-cell receptor (TCR)-modified lymphocytes has been recently reported to cause objective cancer regression. However, a major limitation to this approach is the mispairing of the introduced chains with the endogenous TCR subunits, which leads to reduced TCR surface expression and, subsequently, to their lower biological activity. We here show that it is possible to improve TCR gene transfer by adding a single cysteine on each receptor chain to promote the formation of an additional interchain disulfide bond. We show that cysteine-modified receptors were more highly expressed on the surface of human lymphocytes compared with their wild-type counterparts and able to mediate higher levels of cytokine secretion and specific lysis when cocultured with specific tumor cell lines. Furthermore, cysteine-modified receptors retained their enhanced function in CD4 super(+) lymphocytes. We also show that this approach can be employed to enhance the function of humanized and native murine receptors in human cells. Preferential pairing of cysteine-modified receptor chains accounts for these observations, which could have significant implications for the improvement of TCR gene therapy. [Cancer Res 2007; 67(8):3898-903] JF - Cancer Research AU - Cohen, Cyrille J AU - Li, Yong F AU - El-Gamil, Mona AU - Robbins, Paul F AU - Rosenberg, Steven A AU - Morgan, Richard A AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 3898 EP - 3903 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 67 IS - 8 SN - 0008-5472, 0008-5472 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - T-cell receptor KW - Gene therapy KW - Receptor mechanisms KW - double prime T-cell receptor KW - Disulfide bonds KW - Cancer KW - CD4 antigen KW - Tumor cell lines KW - Cysteine KW - Lymphocytes T KW - Adoptive transfer KW - Cytokines KW - Antitumor activity KW - W 30905:Medical Applications KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20797419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Enhanced+Antitumor+Activity+of+T+Cells+Engineered+to+Express+T-Cell+Receptors+with+a+Second+Disulfide+Bond&rft.au=Cohen%2C+Cyrille+J%3BLi%2C+Yong+F%3BEl-Gamil%2C+Mona%3BRobbins%2C+Paul+F%3BRosenberg%2C+Steven+A%3BMorgan%2C+Richard+A&rft.aulast=Cohen&rft.aufirst=Cyrille&rft.date=2007-04-01&rft.volume=67&rft.issue=8&rft.spage=3898&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - T-cell receptor; Receptor mechanisms; Gene therapy; double prime T-cell receptor; Disulfide bonds; Cancer; Tumor cell lines; CD4 antigen; Cysteine; Adoptive transfer; Lymphocytes T; Cytokines; Antitumor activity ER - TY - JOUR T1 - Sortase-Catalyzed Assembly of Distinct Heteromeric Fimbriae in Actinomyces naeslundii AN - 20743980; 7406641 AB - Two types of adhesive fimbriae are expressed by Actinomyces; however, the architecture and the mechanism of assembly of these structures remain poorly understood. In this study we characterized two fimbrial gene clusters present in the genome of Actinomyces naeslundii strain MG-1. By using immunoelectron microscopy and biochemical analysis, we showed that the fimQ-fimP-srtC1-fimR gene cluster encodes a fimbrial structure (designated type 1) that contains a major subunit, FimP, forming the shaft and a minor subunit, FimQ, located primarily at the tip. Similarly, the fimB-fimA-srtC2 gene cluster encodes a distinct fimbrial structure (designated type 2) composed of a shaft protein, FimA, and a tip protein, FimB. By using allelic exchange, we constructed an in-frame deletion mutant that lacks the SrtC2 sortase. This mutant produces abundant type 1 fimbriae and expresses the monomeric FimA and FimB proteins, but it does not assemble type 2 fimbriae. Thus, SrtC2 is a fimbria-specific sortase that is essential for assembly of the type 2 fimbriae. Together, our experiments pave the way for several lines of molecular investigation that are necessary to elucidate the fimbrial assembly pathways in Actinomyces and their function in the pathogenesis of different biofilm-related oral diseases. JF - Journal of Bacteriology AU - Mishra, Arunima AU - Das, Asis AU - Cisar, John O AU - Ton-That, Hung AD - Department of Molecular, Microbial, and Structural Biology, University of Connecticut Health Center, 263 Farmington Ave., Farmington, Connecticut 06030. Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Bethesda, Maryland 20892 Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 3156 EP - 3165 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 189 IS - 8 SN - 0021-9193, 0021-9193 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Genomes KW - Deletion mutant KW - Oral diseases KW - Pili KW - Gene clusters KW - Biochemical analysis KW - Immunoelectron microscopy KW - sortase KW - Adhesives KW - Actinomyces naeslundii KW - J 02320:Cell Biology KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20743980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Sortase-Catalyzed+Assembly+of+Distinct+Heteromeric+Fimbriae+in+Actinomyces+naeslundii&rft.au=Mishra%2C+Arunima%3BDas%2C+Asis%3BCisar%2C+John+O%3BTon-That%2C+Hung&rft.aulast=Mishra&rft.aufirst=Arunima&rft.date=2007-04-01&rft.volume=189&rft.issue=8&rft.spage=3156&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; Deletion mutant; Oral diseases; Pili; Gene clusters; Biochemical analysis; Immunoelectron microscopy; Adhesives; sortase; Actinomyces naeslundii ER - TY - JOUR T1 - Confirmation of a Positive Association between Prostate Cancer Risk and a Locus at Chromosome 8q24 AN - 20730054; 7404969 AB - Background: Family-based linkage studies, association studies, and studies of tumors have highlighted human chromosome 8q as a genomic region of interest for prostate cancer susceptibility loci. Recently, a locus at 8q24, characterized by both a single nucleotide polymorphism (SNP) and a microsatellite marker, was shown to be associated with prostate cancer risk in Icelandic, Swedish, and U.S. samples. Although the data were provocative, the U.S. samples were not population based, which precludes assessment of the potential contribution of this locus to prostate cancer incidence in the United States. Methods: We analyzed both markers in a population-based, case-control study of middle-aged men from King County, Washington. Results: Overall, there was a significant positive association between the A allele of the SNP rs1447295 and prostate cancer risk [odds ratio, 1.4; 95% confidence interval (95% CI), 1.1-2.0] but no significant association with the microsatellite DG8S737. However, significant associations were observed for both markers in men with high Gleason scores. Adjusting for age, first-degree family history of prostate cancer, and prostate cancer screening history, the adjusted odds ratios were 1.4 (95% CI, 1.1-1.8) for the A allele of the SNP and 1.9 (95% CI, 1.2-2.8) for the -10 allele of the microsatellite. Conclusions: These data suggest that the locus on chromosome 8q24 harbors a genetic variant associated with prostate cancer and that the microsatellite marker is a stronger risk factor for aggressive prostate cancers defined by poorly differentiated tumor morphology. (Cancer Epidemiol Biomarkers Prev 2007; 16(4):809-14) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Suuriniemi, Miia AU - Agalliu, Ilir AU - Schaid, Daniel J AU - Johanneson, Bo AU - McDonnell, Shannon K AU - Iwasaki, Lori AU - Stanford, Janet L AU - Ostrander, Elaine A AD - Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 809 EP - 814 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 4 SN - 1055-9965, 1055-9965 KW - Genetics Abstracts; Risk Abstracts KW - Bioindicators KW - Historical account KW - Age KW - Microsatellites KW - tumors KW - Tumors KW - biomarkers KW - Cancer KW - USA, Washington KW - Genetics KW - chromosome 8 KW - Chromosomes KW - Prostate cancer KW - Single-nucleotide polymorphism KW - Risk factors KW - Morphology KW - Genetic markers KW - prevention KW - genomics KW - prostate cancer KW - G 07880:Human Genetics KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20730054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Confirmation+of+a+Positive+Association+between+Prostate+Cancer+Risk+and+a+Locus+at+Chromosome+8q24&rft.au=Suuriniemi%2C+Miia%3BAgalliu%2C+Ilir%3BSchaid%2C+Daniel+J%3BJohanneson%2C+Bo%3BMcDonnell%2C+Shannon+K%3BIwasaki%2C+Lori%3BStanford%2C+Janet+L%3BOstrander%2C+Elaine+A&rft.aulast=Suuriniemi&rft.aufirst=Miia&rft.date=2007-04-01&rft.volume=16&rft.issue=4&rft.spage=809&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - chromosome 8; Prostate cancer; Single-nucleotide polymorphism; Risk factors; Genetic markers; Microsatellites; genomics; Tumors; biomarkers; Bioindicators; Historical account; Genetics; Age; Chromosomes; Morphology; prevention; tumors; prostate cancer; Cancer; USA, Washington ER - TY - JOUR T1 - Glioma Risk in Relation to Serum Levels of Insulin-Like Growth Factors AN - 20729320; 7404976 AB - Several studies have suggested that insulin-like growth factors (IGF) are related to cancer risk. We investigated the associations between serum levels of IGF-I and IGF-binding protein-3 and glioma risk. A nested case-control study was conducted within a cancer prevention study, including 29,133 men (ages 50-69 years). In total, 22 glioma cases and 400 randomly selected controls were included. Serum samples were collected a minimum of 5 years before cancer diagnosis. Serum concentrations were measured using ELISA and divided into tertiles based on measurements among controls. Odds ratios and 95% confidence intervals were calculated using the lowest tertile as the reference category. No statistical association was detected between glioma and IGF-binding protein-3. IGF-I was inversely associated with glioma when comparing the lowest tertile with the other tertiles combined (odds ratio, 0.3; 95% confidence interval, 0.1-0.7). The results encourage future research on IGFs in relation to brain tumors in larger studies. (Cancer Epidemiol Biomarkers Prev 2007; 16(4):844-6) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Loenn, Stefan AU - Inskip, Peter D AU - Pollak, Michael N AU - Weinstein, Stephanie J AU - Virtamo, Jarmo AU - Albanes, Demetrius AD - Radiation Epidemiology Branch and Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 844 EP - 846 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 4 SN - 1055-9965, 1055-9965 KW - Risk Abstracts; Oncogenes & Growth Factors Abstracts; CSA Neurosciences Abstracts KW - Bioindicators KW - Insulin-like growth factor I KW - Age KW - Enzyme-linked immunosorbent assay KW - Statistics KW - biomarkers KW - Cancer KW - Brain tumors KW - Serum levels KW - glioma KW - Insulin-like growth factors KW - prevention KW - Glioma KW - growth factors KW - brain tumors KW - B 26600:Tyrosine Kinase Activity KW - R2 23060:Medical and environmental health KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20729320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Glioma+Risk+in+Relation+to+Serum+Levels+of+Insulin-Like+Growth+Factors&rft.au=Loenn%2C+Stefan%3BInskip%2C+Peter+D%3BPollak%2C+Michael+N%3BWeinstein%2C+Stephanie+J%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius&rft.aulast=Loenn&rft.aufirst=Stefan&rft.date=2007-04-01&rft.volume=16&rft.issue=4&rft.spage=844&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Serum levels; Brain tumors; Insulin-like growth factor I; Enzyme-linked immunosorbent assay; Statistics; Insulin-like growth factors; Glioma; biomarkers; Bioindicators; glioma; Age; prevention; brain tumors; growth factors; Cancer ER - TY - JOUR T1 - The influence of tumor oxygenation on hypoxia imaging in murine squamous cell carcinoma using [64Cu]Cu-ATSM or [18F]Fluoromisonidazole positron emission tomography AN - 20623506; 9360958 AB - [64Cu]Cu(II)-ATSM (64Cu-ATSM) and [18F]-Fluoromisonidazole (18F-FMiso) tumor binding as assessed by positron emisson topography (PET) was used to determine the responsiveness of each probe to modulation in tumor oxygenation levels in the SCCVII tumor model. Animals bearing the SCCVII tumor were injected with 64Cu-ATSM or 18F-FMiso followed by dynamic small animal PET imaging. Animals were imaged with both agents using different inspired oxygen mixtures (air, 10% oxygen, carbogen) which modulated tumor hypoxia as independently assessed by the hypoxia marker pimonidazole. The extent of hypoxia in the SCCVII tumor as monitored by the pimonidazole hypoxia marker was found to be in the following order: 10% oxygen > air > carbogen. Tumor uptake of 64Cu-ATSM could not be changed if the tumor was oxygenated using carbogen inhalation 90 min post-injection suggesting irreversible cellular uptake of the 64Cu-ATSM complex. A small but significant paradoxical increase in 64Cu-ATSM tumor uptake was observed for animals breathing air or carbogen compared to 10% oxygen. There was a positive trend toward 18F-FMiso tumor uptake as a function of changing hypoxia levels in agreement with the pimonidazole data. 64Cu-ATSM tumor uptake was unable to predictably detect changes in varying amounts of hypoxia when oxygenation levels in SCCVII tumors were modulated. 18F-FMiso tumor uptake was more responsive to changing levels of hypoxia. While the mechanism of nitroimidazole binding to hypoxic cells has been extensively studied, the avid binding of Cu-ATSM to tumors may involve other mechanisms independent of hypoxia that warrant further study. JF - International Journal of Oncology AU - Matsumoto, K-I AU - Szajek, L AU - Krishna, M C AU - Cook, JA AU - Seidel, J AU - Grimes, K AU - Carson, J AU - Sowers, AL AU - English, S AU - Green, M V AU - Bacharach, S L AU - Eckelman, W C AU - Mitchell, J B AD - Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 873 EP - 881 VL - 30 IS - 4 SN - 1019-6439, 1019-6439 KW - Biotechnology and Bioengineering Abstracts KW - Inhalation KW - Data processing KW - Respiration KW - Animal models KW - Probes KW - squamous cell carcinoma KW - Tumors KW - Oxygen KW - Hypoxia KW - Positron emission tomography KW - Nitroimidazole KW - Topography KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20623506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Oncology&rft.atitle=The+influence+of+tumor+oxygenation+on+hypoxia+imaging+in+murine+squamous+cell+carcinoma+using+%5B64Cu%5DCu-ATSM+or+%5B18F%5DFluoromisonidazole+positron+emission+tomography&rft.au=Matsumoto%2C+K-I%3BSzajek%2C+L%3BKrishna%2C+M+C%3BCook%2C+JA%3BSeidel%2C+J%3BGrimes%2C+K%3BCarson%2C+J%3BSowers%2C+AL%3BEnglish%2C+S%3BGreen%2C+M+V%3BBacharach%2C+S+L%3BEckelman%2C+W+C%3BMitchell%2C+J+B&rft.aulast=Matsumoto&rft.aufirst=K-I&rft.date=2007-04-01&rft.volume=30&rft.issue=4&rft.spage=873&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Oncology&rft.issn=10196439&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Inhalation; Oxygen; Data processing; Respiration; Hypoxia; Probes; Animal models; Positron emission tomography; squamous cell carcinoma; Nitroimidazole; Tumors; Topography ER - TY - JOUR T1 - Mortality among Pesticide Applicators Exposed to Chlorpyrifos in the Agricultural Health Study AN - 20586372; 7355656 AB - BACKGROUND: Chlorpyrifos is one of the most widely used organophosphate insecticides in the United States. Although the toxicity of chlorpyrifos has been extensively studied in animals, the epidemiologic data are limited. OBJECTIVE: To evaluate whether agricultural chlorpyrifos exposure was associated with mortality, we examined deaths among pesticide applicators in the Agricultural Health Study, a prospective study of licensed pesticide applicators in Iowa and North Carolina. METHODS: A total of 55,071 pesticide applicators were included in this analysis. Detailed pesticide exposure data and other information were obtained from self-administered questionnaires completed at the time of enrollment (1993-1997). Lifetime chlorpyrifos use was divided into tertiles. Poisson regression analysis was used to evaluate the exposure-response relationships between chlorpyrifos use and causes of death after adjustment for potential confounders. RESULTS: A total of 1,851 deaths (588 among chlorpyrifos users) were observed during the study period, 1993-2001. The relative risk (RR) of death from all causes combined among applicators exposed to chlorpyrifos was slightly lower than that for nonexposed applicators (RR = 0.90; 95% confidence interval, 0.81-1.01). For most causes of death analyzed, there was no evidence of an exposure-response relationship. However, the relative risks for mortality from suicide and non-motor-vehicle accidents were increased 2-fold in the highest category of chlorpyrifos exposure days. CONCLUSIONS: Our findings of a possible association between chlorpyrifos use and external causes of death were based on small numbers. However, the findings may reflect a link between chlorpyrifos and depression or other neurobehavioral symptoms that deserves further evaluation. JF - Environmental Health Perspectives AU - Lee, W J AU - Alavanja, MCR AU - Hoppin, JA AU - Rusiecki, JA AU - Kamel, F AU - Blair, A AU - Sandier, D P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA, sandier@mail.nih.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 528 EP - 534 VL - 115 IS - 4 SN - 0091-6765, 0091-6765 KW - Risk Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - Risk assessment KW - USA, North Carolina KW - Organophosphates KW - Suicide KW - Accidents KW - Insecticides KW - Dose-response effects KW - Regression analysis KW - suicide KW - Occupational exposure KW - Inventories KW - Mortality KW - Depression KW - organophosphates KW - Toxicity KW - Agrochemicals KW - Chlorpyrifos KW - USA, Iowa KW - Pesticides KW - R2 23080:Industrial and labor KW - H 5000:Pesticides KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20586372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Mortality+among+Pesticide+Applicators+Exposed+to+Chlorpyrifos+in+the+Agricultural+Health+Study&rft.au=Lee%2C+W+J%3BAlavanja%2C+MCR%3BHoppin%2C+JA%3BRusiecki%2C+JA%3BKamel%2C+F%3BBlair%2C+A%3BSandier%2C+D+P&rft.aulast=Lee&rft.aufirst=W&rft.date=2007-04-01&rft.volume=115&rft.issue=4&rft.spage=528&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.9662 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; Mortality; Inventories; Depression; Suicide; Toxicity; organophosphates; Chlorpyrifos; Accidents; Insecticides; Dose-response effects; Pesticides; Regression analysis; Organophosphates; Agrochemicals; Occupational exposure; suicide; USA, North Carolina; USA, Iowa DO - http://dx.doi.org/10.1289/ehp.9662 ER - TY - JOUR T1 - Cre-loxP-Mediated Recombination between the SIL and SCL Genes Leads to a Block in T-Cell Development at the CD4 super(-)CD8 super(-) to CD4 super(+)CD8 super(+) Transition AN - 20531246; 7791780 AB - In the most common form of stem cell leukemia (SCL) gene rearrangement, an interstitial deletion of 82 kb brings SCL under the control of regulatory elements that normally govern expression of the ubiquitously expressed SCL interrupting locus (SIL) gene, which is located directly upstream of SCL. To investigate the effect of this fusion in a mouse model, a bacterial artificial chromosome (BAC) clone containing both human SIL and SCL genes was isolated, and loxP sites were inserted into intron 1 of both the SIL and SCL genes, corresponding to the sites at which recombination occurs in human T-cell acute lymphocytic leukemia patients. This BAC clone was used to generate transgenic SILloxloxSCL mice. These transgenic mice were subsequently bred to Lck-Cre mice that express the Cre recombinase specifically in the thymus. The BAC transgene was recombined between the two loxP sites in over 50% of the thymocytes from SILloxloxSCL/Cre double-transgenic mice, bringing the SCL gene under the direct control of SIL regulatory elements. Aberrant SCL gene expression in the thymus was verified by reverse transcription-polymerase chain reaction. Using FACS analysis, we found that mice carrying both SILloxloxSCL and Cre transgenes have increased CD4 super(-)/CD8 super(-) thymocytes compared with transgene-negative mice. In the spleen, these transgenic mice show a marked reduction in the number of mature CD4 super(+) or CD8 super(+) cells. These results demonstrate that conditional activation of SCL under control of SIL regulatory elements can impair normal T-cell development. JF - Neoplasia AU - Cheng, Y AU - Zhang, Z AU - Slape, C AU - Aplan, P D AD - Genetics Branch, Center for Cancer Research, National Cancer Institute, National Naval Medical Center, Building 8, Room 5101, 8901 Wisconsin Avenue, Bethesda, MD 20889-5105, USA, aplanp@mail.nih.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 315 EP - 121 VL - 9 IS - 4 SN - 1522-8002, 1522-8002 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Immunology Abstracts KW - sil gene KW - Regulatory sequences KW - Thymus KW - Transgenes KW - Animal models KW - Lymphatic leukemia KW - Spleen KW - scl gene KW - Stem cell leukemia KW - CD8 antigen KW - Development KW - Transgenic mice KW - Bacterial artificial chromosomes KW - Flow cytometry KW - Recombination KW - CD4 antigen KW - Gene deletion KW - gene rearrangement KW - Lymphocytes T KW - Cre recombinase KW - Introns KW - Thymocytes KW - J 02320:Cell Biology KW - F 06915:Cancer Immunology KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20531246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neoplasia&rft.atitle=Cre-loxP-Mediated+Recombination+between+the+SIL+and+SCL+Genes+Leads+to+a+Block+in+T-Cell+Development+at+the+CD4+super%28-%29CD8+super%28-%29+to+CD4+super%28%2B%29CD8+super%28%2B%29+Transition&rft.au=Cheng%2C+Y%3BZhang%2C+Z%3BSlape%2C+C%3BAplan%2C+P+D&rft.aulast=Cheng&rft.aufirst=Y&rft.date=2007-04-01&rft.volume=9&rft.issue=4&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Neoplasia&rft.issn=15228002&rft_id=info:doi/10.1593%2Fneo.07148 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - sil gene; Regulatory sequences; Transgenes; Thymus; Lymphatic leukemia; Animal models; Spleen; scl gene; Development; CD8 antigen; Stem cell leukemia; Transgenic mice; Flow cytometry; Bacterial artificial chromosomes; Recombination; Gene deletion; CD4 antigen; gene rearrangement; Introns; Cre recombinase; Lymphocytes T; Thymocytes DO - http://dx.doi.org/10.1593/neo.07148 ER - TY - JOUR T1 - Bridging the gap in RNA structure prediction AN - 20480441; 7657519 AB - The field of RNA structure prediction has experienced significant advances in the past several years, thanks to the availability of new experimental data and improved computational methodologies. These methods determine RNA secondary structures and pseudoknots from sequence alignments, thermodynamics-based dynamic programming algorithms, genetic algorithms and combined approaches. Computational RNA three-dimensional modeling uses this information in conjunction with manual manipulation, constraint satisfaction methods, molecular mechanics and molecular dynamics. The ultimate goal of automatically producing RNA three-dimensional models from given secondary and tertiary structure data, however, is still not fully realized. Recent developments in the computational prediction of RNA structure have helped bridge the gap between RNA secondary structure prediction, including pseudoknots, and three-dimensional modeling of RNA. JF - Current Opinion in Structural Biology AU - Shapiro, Bruce A AU - Yingling, Yaroslava G AU - Kasprzak, Wojciech AU - Bindewald, Eckart AD - Center for Cancer Research Nanobiology Program, NCI-Frederick, Building 469, Room 150, Frederick, MD 21702, USA, bshapiro@ncifcrf.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 157 EP - 165 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 17 IS - 2 SN - 0959-440X, 0959-440X KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Protein structure KW - RNA KW - Reviews KW - Nucleotide sequence KW - Secondary structure KW - Algorithms KW - Computer applications KW - Tertiary structure KW - N 14830:RNA KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20480441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Structural+Biology&rft.atitle=Bridging+the+gap+in+RNA+structure+prediction&rft.au=Shapiro%2C+Bruce+A%3BYingling%2C+Yaroslava+G%3BKasprzak%2C+Wojciech%3BBindewald%2C+Eckart&rft.aulast=Shapiro&rft.aufirst=Bruce&rft.date=2007-04-01&rft.volume=17&rft.issue=2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Structural+Biology&rft.issn=0959440X&rft_id=info:doi/10.1016%2Fj.sbi.2007.03.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Protein structure; RNA; Nucleotide sequence; Reviews; Secondary structure; Algorithms; Tertiary structure; Computer applications DO - http://dx.doi.org/10.1016/j.sbi.2007.03.001 ER - TY - JOUR T1 - Geographical distribution and risk factors associated with enteric diseases in Vietnam AN - 20449197; 7958066 AB - In Vietnam, shigellosis, typhoid fever, and cholera are important enteric diseases. To determine their magnitude and geographical distribution, and explore associated risk factors, we examined national surveillance data from 1991 to 2001 and potential ecological determinants. Average annual incidence rates were calculated and mapped for each province. Bivariate and multiple regression analyses were used to explore associations with selected environmental and human risk factors. Overall, shigellosis rates per 100,000 population (median, 41; mean, 70) were higher and more widespread than rates for typhoid fever (median, 7; mean, 23) and cholera (median, 0.3; mean, 2.7). Shigellosis was highest in the Central Highlands and was significantly associated with rainfall and urban poverty; typhoid fever prevailed in the Mekong River Delta and was most associated with vapor pressure and river/stream drinking water; and cholera predominated along the Central Coastal regions and correlated positively with rainfall and public well drinking water. The distinct geographical patterns of each disease appear to be driven by a combination of different ecological factors. JF - American Journal of Tropical Medicine and Hygiene AU - Kelly-Hope, LA AU - Alonso, W J AU - Thiem, V D AU - Anh, D D AU - Canh, D G AU - Lee, H AU - Smith, D L AU - Miller, MA AD - Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 706 EP - 712 VL - 76 IS - 4 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts B: Bacteriology; Risk Abstracts KW - Rivers KW - Geographical distribution KW - Data processing KW - Rainfall KW - Multiple regression analysis KW - Streams KW - Vietnam KW - Ecology KW - Vapors KW - Shigellosis KW - Poverty KW - Risk factors KW - Cholera KW - Diseases KW - Pressure KW - Drinking water KW - Typhoid fever KW - R2 23060:Medical and environmental health KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20449197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Geographical+distribution+and+risk+factors+associated+with+enteric+diseases+in+Vietnam&rft.au=Kelly-Hope%2C+LA%3BAlonso%2C+W+J%3BThiem%2C+V+D%3BAnh%2C+D+D%3BCanh%2C+D+G%3BLee%2C+H%3BSmith%2C+D+L%3BMiller%2C+MA&rft.aulast=Kelly-Hope&rft.aufirst=LA&rft.date=2007-04-01&rft.volume=76&rft.issue=4&rft.spage=706&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Rivers; Geographical distribution; Data processing; Rainfall; Multiple regression analysis; Streams; Vapors; Shigellosis; Risk factors; Cholera; Typhoid fever; Drinking water; Pressure; Ecology; Poverty; Diseases; Vietnam ER - TY - JOUR T1 - Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii AN - 20445256; 9125500 AB - SummaryMost intracellular parasites employ sophisticated mechanisms to direct biogenesis of a vacuolar replicative niche that circumvents default maturation through the endolysosomal cascade. However, this is not the case of the Q fever bacterium, Coxiella burnetii. This hardy, obligate intracellular pathogen has evolved to not only survive, but to thrive, in the harshest of intracellular compartments: the phagolysosome. Following internalization, the nascent Coxiella phagosome ultimately develops into a large and spacious parasitophorous vacuole (PV) that acquires lysosomal characteristics such as acidic pH, acid hydrolases and cationic peptides, defences designed to rid the host of intruders. However, transit of Coxiella to this environment is initially stalled, a process that is apparently modulated by interactions with the autophagic pathway. Coxiella actively participates in biogenesis of its PV by synthesizing proteins that mediate phagosome stalling, autophagic interactions, and development and maintenance of the mature vacuole. Among the potential mechanisms mediating these processes is deployment of a type IV secretion system to deliver effector proteins to the host cytosol. Here we summarize our current understanding of the cellular events that occur during parasitism of host cells by Coxiella. JF - Cellular Microbiology AU - Voth, Daniel E AU - Heinzen, Robert A AD - Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 829 EP - 840 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 9 IS - 4 SN - 1462-5814, 1462-5814 KW - Microbiology Abstracts B: Bacteriology KW - Secretion KW - Phagosomes KW - Pathogens KW - Cationic peptides KW - Parasitism KW - double prime Q fever KW - hydrolase KW - parasitophorous vacuole KW - Coxiella burnetii KW - Intruder KW - Phagolysosomes KW - Reviews KW - Vacuoles KW - Cytosol KW - pH effects KW - Lysosomes KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20445256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+Microbiology&rft.atitle=Lounging+in+a+lysosome%3A+the+intracellular+lifestyle+of+Coxiella+burnetii&rft.au=Voth%2C+Daniel+E%3BHeinzen%2C+Robert+A&rft.aulast=Voth&rft.aufirst=Daniel&rft.date=2007-04-01&rft.volume=9&rft.issue=4&rft.spage=829&rft.isbn=&rft.btitle=&rft.title=Cellular+Microbiology&rft.issn=14625814&rft_id=info:doi/10.1111%2Fj.1462-5822.2007.00901.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Secretion; Phagosomes; Pathogens; Cationic peptides; Parasitism; double prime Q fever; parasitophorous vacuole; hydrolase; Phagolysosomes; Intruder; Reviews; Vacuoles; Cytosol; pH effects; Lysosomes; Coxiella burnetii DO - http://dx.doi.org/10.1111/j.1462-5822.2007.00901.x ER - TY - JOUR T1 - Synthesis, purification and sample experiment for fluorescent pteridine- containing DNA: tools for studying DNA interactive systems AN - 20364115; 7632867 AB - Fluorescent nucleoside analogs provide a means to study DNA interactive systems through direct measurement of fluorescence properties. As integrated parts of DNA, these probes provide opportunities for monitoring subtle changes in DNA structure as it meets and reacts with other molecules. This protocol describes modifications to standard DNA synthesis to efficiently use smaller volumes of the probe phosphoramidite, purification of pteridine- containing sequences and a deprotection procedure specific for 6MI-containing sequences. Yields for probe incorporation in DNA synthesis are comparable to those for standard phosphoramidites. Examples of the fluorescence signals one can expect are described. Automated synthesis, which is dependent on the length of the sequence, takes about 4-5 h for a 20-mer. The deprotection of 6MI-containing sequences takes approximately 6-7 h before the standard ammonium hydroxide overnight incubation. Purification through polyacrylamide gels, electroelution and ethanol precipitation can be accomplished in 6-8 h. JF - Nature Protocols AU - Hawkins, Mary E Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 1013 EP - 1021 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 2 IS - 4 SN - 1754-2189, 1754-2189 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Ammonium KW - DNA biosynthesis KW - Fluorescence KW - Nucleotide sequence KW - DNA probes KW - Precipitation KW - Gels KW - nucleoside analogs KW - DNA structure KW - Ethanol KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20364115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Protocols&rft.atitle=Synthesis%2C+purification+and+sample+experiment+for+fluorescent+pteridine-+containing+DNA%3A+tools+for+studying+DNA+interactive+systems&rft.au=Hawkins%2C+Mary+E&rft.aulast=Hawkins&rft.aufirst=Mary&rft.date=2007-04-01&rft.volume=2&rft.issue=4&rft.spage=1013&rft.isbn=&rft.btitle=&rft.title=Nature+Protocols&rft.issn=17542189&rft_id=info:doi/10.1038%2Fnprot.2007.150 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - DNA probes; Fluorescence; DNA biosynthesis; Precipitation; nucleoside analogs; Ethanol; DNA structure; Nucleotide sequence; Gels; Ammonium DO - http://dx.doi.org/10.1038/nprot.2007.150 ER - TY - JOUR T1 - Covalent surface chemistry gradients for presenting bioactive peptides AN - 20295557; 7536906 AB - The activation of surfaces by covalent attachment of bioactive moieties is an important strategy for improving the performance of biomedical materials. Such techniques have also been used as tools to study cellular responses to particular chemistries of interest. The creation of gradients of covalently bound chemistries is a logical extension of this technique. Gradient surfaces may permit the rapid screening of a large range of concentrations in a single experiment. In addition, the biological response to the gradient itself may provide new information on receptor requirements and cell signaling. The current work describes a rapid and flexible technique for the covalent addition of bioactive peptide gradients to a surface or gel and a simple fluorescence technique for assaying the gradient. In this technique, bioactive peptides with a terminal cysteine are bound via a heterobifunctional coupling agent to primary amine-containing surfaces and gels. A gradient in the coupling agent is created on the surfaces or gels by varying the residence time of the coupling agent across the surface or gel, thereby controlling the extent of reaction. We demonstrate this technique using poly(l-lysine)-coated glass surfaces and fibrin gels. Once the surface or gel has been activated by the addition of the coupling agent gradient, the bioactive peptide is added. Quantitation of the gradient is achieved by measuring the reaction kinetics of the coupling agent with the surface or gel of interest. This can be done either by fluorescently labeling the coupling agent (in the case of surfaces) or by spectrophotometrically detecting the release of pyridine-2-thione, which is produced when the thiol-reactive portion of the coupling agent reacts. By these methods, we can obtain reasonably precise estimates for the peptide gradients without using expensive spectroscopic or radiolabeling techniques. Validation with changes in fibroblast cell migration behavior across a bioactive peptide gradient illustrates preservation of peptide function as well as the usefulness of this technique. JF - Analytical Biochemistry AU - Kipper, Matt J AU - Kleinman, Hynda K AU - Wang, Francis W AD - National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA, francis.wang@nist.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 175 EP - 184 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 363 IS - 2 SN - 0003-2697, 0003-2697 KW - Biotechnology and Bioengineering Abstracts KW - Peptide gradients KW - Cell migration KW - Epifluorescence microscopy KW - Gels KW - Fluorescence KW - Cysteine KW - Kinetics KW - fibrin KW - Preservation KW - Quantitation KW - Fibroblasts KW - Signal transduction KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20295557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Biochemistry&rft.atitle=Covalent+surface+chemistry+gradients+for+presenting+bioactive+peptides&rft.au=Kipper%2C+Matt+J%3BKleinman%2C+Hynda+K%3BWang%2C+Francis+W&rft.aulast=Kipper&rft.aufirst=Matt&rft.date=2007-04-01&rft.volume=363&rft.issue=2&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Analytical+Biochemistry&rft.issn=00032697&rft_id=info:doi/10.1016%2Fj.ab.2007.01.036 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gels; Fluorescence; Cysteine; Kinetics; fibrin; Preservation; Cell migration; Quantitation; Signal transduction; Fibroblasts DO - http://dx.doi.org/10.1016/j.ab.2007.01.036 ER - TY - JOUR T1 - Disruption of the female reproductive system by the phytoestrogen genistein AN - 20266077; 7497200 AB - Studies in our laboratory have shown that developmental exposure to genistein causes deleterious effects on the reproductive system. Oral exposure to genistin (25mg/kg) increases uterine weight at 5 days of age similar to subcutaneous injection of genistein (20mg /kg) suggesting that subcutaneous injection of genistein is a suitable model for oral exposure to genistin. Mice treated neonatally by subcutaneous injection of genistein (0.5-50mg/kg) exhibit altered ovarian differentiation leading to multi-oocyte follicles (MOFs). Ovarian function and estrous cyclicity were disrupted in genistein treated mice with increasing severity over time. Reduced fertility was observed in mice treated with genistein (0.5, 5, or 25mg/kg) and infertility was observed at 50mg/kg. Females generated from genistein 25mg/kg females bred to control males have increased MOFs suggesting these effects can be transmitted to subsequent generations. Thus, neonatal treatment with genistein at environmentally relevant doses caused adverse consequences on reproduction in adulthood. JF - Reproductive Toxicology AU - Jefferson, W N AU - Padilla-Banks, E AU - Newbold, R R AD - Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, P.O. Box 12233, Research Triangle Park, NC 27709, United States, jeffers1@niehs.nih.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 308 EP - 316 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 23 IS - 3 SN - 0890-6238, 0890-6238 KW - Toxicology Abstracts KW - Infertility KW - Fertility KW - Uterus KW - Follicles KW - Reproductive system KW - Models KW - Differentiation KW - Phytoestrogens KW - Reproduction KW - Neonates KW - Genistein KW - Estrus cycle KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20266077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+Toxicology&rft.atitle=Disruption+of+the+female+reproductive+system+by+the+phytoestrogen+genistein&rft.au=Jefferson%2C+W+N%3BPadilla-Banks%2C+E%3BNewbold%2C+R+R&rft.aulast=Jefferson&rft.aufirst=W&rft.date=2007-04-01&rft.volume=23&rft.issue=3&rft.spage=308&rft.isbn=&rft.btitle=&rft.title=Reproductive+Toxicology&rft.issn=08906238&rft_id=info:doi/10.1016%2Fj.reprotox.2006.11.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Differentiation; Infertility; Uterus; Fertility; Follicles; Phytoestrogens; Reproduction; Neonates; Estrus cycle; Reproductive system; Genistein; Models DO - http://dx.doi.org/10.1016/j.reprotox.2006.11.012 ER - TY - JOUR T1 - The rise in pertussis cases urges replacement of chemically-inactivated with genetically-inactivated toxoid for DTP AN - 20233013; 7640560 AB - The number of pertussis cases reported to the CDC increased from 5158 in 1995 to 21,503 in 2005. Most of the increase was in individuals greater than 10 years of age. This increase occurred also in other developed nations despite high coverage of infants and young children with the acellular pertussis vaccine. In Goteborg Sweden, virtual elimination of pertussis occurred following immunization of 70% of the children less than 10 years old with monocomponent pertussis toxoid (PTx). Immunity following disease or vaccination with either the cellular or acellular pertussis vaccine wanes gradually so that older children and adults may again become susceptible. Currently, PTx is made from chemically-inactivated pertussis toxin (PT). The most immunogenic PTx is made from genetically-inactivated mutant PT that induces higher levels of IgG anti-PT at all ages. Because of its greater immunogenicity, the genetically-inactivated PTx can be expected to be more protective on an individual and on a community basis for a longer duration than the current product. Manufacturers have declined to produce the genetically-inactivated PTx because of the expense required to change to the improved vaccine and not because of scientific issues. JF - Vaccine AU - Robbins, John B AU - Schneerson, Rachel AU - Keith, Jerry M AU - Shiloach, Joseph AU - Miller, Mark AU - Trollors, Birger AD - National Institute of Child Health and Human Development, National Institutes of Health, 31 Center Drive, Bethesda, MD 20892-2423, USA, robbinsjo@mail.nih.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 2811 EP - 2816 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 25 IS - 15 SN - 0264-410X, 0264-410X KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Pertussis toxoid KW - Genetically inactivated KW - DTP KW - Pertussis KW - Age KW - Diphtheria KW - Immunity KW - Toxoids KW - Tetanus KW - Children KW - Vaccination KW - pertussis toxin KW - Immunogenicity KW - Immunoglobulin G KW - Vaccines KW - Infants KW - G 07720:Immunogenetics KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20233013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=The+rise+in+pertussis+cases+urges+replacement+of+chemically-inactivated+with+genetically-inactivated+toxoid+for+DTP&rft.au=Robbins%2C+John+B%3BSchneerson%2C+Rachel%3BKeith%2C+Jerry+M%3BShiloach%2C+Joseph%3BMiller%2C+Mark%3BTrollors%2C+Birger&rft.aulast=Robbins&rft.aufirst=John&rft.date=2007-04-01&rft.volume=25&rft.issue=15&rft.spage=2811&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2006.12.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Pertussis; Age; Toxoids; Immunity; Diphtheria; Children; Tetanus; Vaccination; pertussis toxin; Immunogenicity; Immunoglobulin G; Vaccines; Infants DO - http://dx.doi.org/10.1016/j.vaccine.2006.12.013 ER - TY - JOUR T1 - Relaxation and susceptibility MRI characteristics in Hallervorden-Spatz syndrome AN - 20227919; 7459409 AB - To evaluate the imaging characteristics of the brain with respect to relaxation and susceptibility in Hallervorden-Spatz syndrome (HSS), a rare inherited neurodegenerative disorder (also referred to as neurodegeneration with brain iron accumulation). We reviewed 13 affected individuals who satisfied the inclusion criteria for HSS. Clinically, the patients were divided into two groups: early-childhood onset (age of onset before 10 years) and late-childhood onset (age of onset after 10 years). MRI was performed on 1.5T MR equipment. The imaging protocol included spin-echo (SE) T1-weighted (T1W), turbo spin-echo (TSE) T2W, and fluid attenuated inversion recovery (FLAIR) sequences in all patients. Susceptibility-weighted imaging (SWI) included a fast low-angle shot (FLASH) sequence in 10 patients and a blood oxygen level-dependent (BOLD) sequence in two patients. All of the patients showed hyperintensity on T1WI and hypointensity on T2WI in the globus pallidi (GPs) bilaterally. Central or anteromedial hyperintensity was found in all but one patient. FLASH showed augmented hypointensity in 10 patients, and BOLD showed bilateral striatonigral abnormal pigmentation in two patients. MR spectroscopy (MRS) showed normal spectra in four patients, and a reduced NAA/Cho ratio in two. MRI showed prominent signal abnormalities in the GP bilaterally in HSS. T1WI showed hyperintensity in all cases of HSS in addition to the [ldquo]eye-of-the- tiger[rdquo] sign on T2WI. SWI, FLASH, and BOLD demonstrated mineral deposition in the GP better than conventional imaging. Involvement of the striatonigral pathways was demonstrated for the first time on BOLD SWI. J. Magn. Reson. Imaging 2007. JF - Journal of Magnetic Resonance Imaging AU - Desai, Sunali Vinod AU - Bindu, Parayil Shankaran AU - Ravishankar, Shivasankar AU - Jayakumar, Peruvumba Narayan AU - Pal, Pramod Kumar AD - Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, India, sunalidesai@yahoo.com Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 715 EP - 720 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 25 IS - 4 SN - 1053-1807, 1053-1807 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Hallervorden-Spatz syndrome KW - MR imaging KW - SWI KW - BOLD KW - FLASH KW - proton spectroscopy KW - Transmissible spongiform encephalopathy KW - Pigmentation KW - Neurodegenerative diseases KW - Neuroimaging KW - Age KW - Inversion KW - Magnetic resonance spectroscopy KW - Magnetic resonance imaging KW - Brain KW - Iron KW - Minerals KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20227919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Magnetic+Resonance+Imaging&rft.atitle=Relaxation+and+susceptibility+MRI+characteristics+in+Hallervorden-Spatz+syndrome&rft.au=Desai%2C+Sunali+Vinod%3BBindu%2C+Parayil+Shankaran%3BRavishankar%2C+Shivasankar%3BJayakumar%2C+Peruvumba+Narayan%3BPal%2C+Pramod+Kumar&rft.aulast=Desai&rft.aufirst=Sunali&rft.date=2007-04-01&rft.volume=25&rft.issue=4&rft.spage=715&rft.isbn=&rft.btitle=&rft.title=Journal+of+Magnetic+Resonance+Imaging&rft.issn=10531807&rft_id=info:doi/10.1002%2Fjmri.20830 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Transmissible spongiform encephalopathy; Neurodegenerative diseases; Pigmentation; Age; Neuroimaging; Inversion; Magnetic resonance spectroscopy; Magnetic resonance imaging; Brain; Minerals; Iron DO - http://dx.doi.org/10.1002/jmri.20830 ER - TY - JOUR T1 - Accelerated Preclinical Testing Using Transplanted Tumors from Genetically Engineered Mouse Breast Cancer Models AN - 20226476; 7405257 AB - PURPOSE: The use of genetically engineered mouse (GEM) models for preclinical testing of anticancer therapies is hampered by variable tumor latency, incomplete penetrance, and complicated breeding schemes. Here, we describe and validate a transplantation strategy that circumvents some of these difficulties. Experimental Design: Tumor fragments from tumor-bearing MMTV-PyMT or cell suspensions from MMTV-PyMT, -Her2/neu, -wnt1, -wnt1/p53 super(+/-), BRCA1/p53 super(+/-), and C3(1)T-Ag mice were transplanted into the mammary fat pad or s.c. into naive syngeneic or immunosuppressed mice. Tumor development was monitored and tissues were processed for histopathology and gene expression profiling. Metastasis was scored 60 days after the removal of transplanted tumors. RESULTS: PyMT tumor fragments and cell suspensions from anterior glands grew faster than posterior tumors in serial passages regardless of the site of implantation. Microarray analysis revealed genetic differences between these tumors. The transplantation was reproducible using anterior tumors from multiple GEM, and tumor growth rate correlated with the number of transplanted cells. Similar morphologic appearances were observed in original and transplanted tumors. Metastasis developed in >90% of mice transplanted with PyMT, 40% with BRCA1/p53 super(+/-) and wnt1/p53 super(+/-), and 15% with Her2/neu tumors. Expansion of PyMT and wnt1 tumors by serial transplantation for two passages did not lead to significant changes in gene expression. PyMT-transplanted tumors and anterior tumors of transgenic mice showed similar sensitivities to cyclophosphamide and paclitaxel. CONCLUSIONS: Transplantation of GEM tumors can provide a large cohort of mice bearing mammary tumors at the same stage of tumor development and with defined frequency of metastasis in a well-characterized molecular and genetic background. JF - Clinical Cancer Research AU - Varticovski, Lyuba AU - Hollingshead, Melinda G AU - Robles, Ana I AU - Wu, Xiaolin AU - Cherry, James AU - Munroe, David J AU - Lukes, Luanne AU - Anver, Miriam R AU - Carter, John P AU - Borgel, Suzanne D AU - Stotler, Howard AU - Bonomi, Carrie A AU - Nunez, Nomeli P AU - Hursting, Stephen D AU - Qiao, Wenhui AU - Deng, Chuxia X AU - Green, Jeff E AU - Hunter, Kent W AU - Merlino, Glenn AU - Steeg, Patricia S AU - Wakefield, Lalage M AU - Barrett, JCarl AD - Authors' Affiliations: Center for Cancer Research, National Cancer Institute Y1 - 2007/04/01/ PY - 2007 DA - 2007 Apr 01 SP - 2168 EP - 2177 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 13 IS - 7 SN - 1078-0432, 1078-0432 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Growth rate KW - Cell suspensions KW - ErbB-2 protein KW - Mammary gland KW - Animal models KW - Developmental stages KW - Cyclophosphamide KW - Tumors KW - Transgenic mice KW - Gene expression KW - Metastases KW - Breeding KW - Paclitaxel KW - Glands KW - Genetic engineering KW - Breast cancer KW - BRCA1 protein KW - W 30925:Genetic Engineering KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20226476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Accelerated+Preclinical+Testing+Using+Transplanted+Tumors+from+Genetically+Engineered+Mouse+Breast+Cancer+Models&rft.au=Varticovski%2C+Lyuba%3BHollingshead%2C+Melinda+G%3BRobles%2C+Ana+I%3BWu%2C+Xiaolin%3BCherry%2C+James%3BMunroe%2C+David+J%3BLukes%2C+Luanne%3BAnver%2C+Miriam+R%3BCarter%2C+John+P%3BBorgel%2C+Suzanne+D%3BStotler%2C+Howard%3BBonomi%2C+Carrie+A%3BNunez%2C+Nomeli+P%3BHursting%2C+Stephen+D%3BQiao%2C+Wenhui%3BDeng%2C+Chuxia+X%3BGreen%2C+Jeff+E%3BHunter%2C+Kent+W%3BMerlino%2C+Glenn%3BSteeg%2C+Patricia+S%3BWakefield%2C+Lalage+M%3BBarrett%2C+JCarl&rft.aulast=Varticovski&rft.aufirst=Lyuba&rft.date=2007-04-01&rft.volume=13&rft.issue=7&rft.spage=2168&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell suspensions; Growth rate; ErbB-2 protein; Mammary gland; Animal models; Developmental stages; Tumors; Cyclophosphamide; Transgenic mice; Metastases; Gene expression; Breeding; Paclitaxel; Genetic engineering; Glands; BRCA1 protein; Breast cancer ER - TY - JOUR T1 - LC-MS-Based Metabolomics in Drug Metabolism AN - 20176740; 10265833 AB - Xenobiotic metabolism, a ubiquitous natural response to foreign compounds, elicits initiating signals for many pathophysiological events. Currently, most widely used techniques for identifying xenobiotic metabolites and metabolic pathways are empirical and largely based on in vitro incubation assays and in vivo radiotracing experiments. Recent work in our lab has shown that LC-MS-based metabolomic techniques are useful tools for xenobiotic metabolism research since multivariate data analysis in metabolomics can significantly rationalize the processes of xenobiotic metabolite identification and metabolic pathway analysis. In this review, the technological elements of LC-MS-based metabolomics for constructing high-quality datasets and conducting comprehensive data analysis are examined. Four novel approaches of using LC-MS-based metabolomic techniques in xenobiotic metabolism research are proposed and illustrated by case studies and proof-of-concept experiments, and the perspective on their application is further discussed. JF - Drug Metabolism Reviews AU - Chen, Chi AU - Gonzalez, Frank J AU - Idle, Jeffrey R AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 581 EP - 597 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 39 IS - 2-3 SN - 0360-2532, 0360-2532 KW - Toxicology Abstracts KW - Data processing KW - Drug metabolism KW - Metabolic pathways KW - Metabolites KW - metabolomics KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20176740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Metabolism+Reviews&rft.atitle=LC-MS-Based+Metabolomics+in+Drug+Metabolism&rft.au=Chen%2C+Chi%3BGonzalez%2C+Frank+J%3BIdle%2C+Jeffrey+R&rft.aulast=Chen&rft.aufirst=Chi&rft.date=2007-04-01&rft.volume=39&rft.issue=2-3&rft.spage=581&rft.isbn=&rft.btitle=&rft.title=Drug+Metabolism+Reviews&rft.issn=03602532&rft_id=info:doi/10.1080%2F03602530701497804 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Drug metabolism; Metabolic pathways; Metabolites; metabolomics DO - http://dx.doi.org/10.1080/03602530701497804 ER - TY - JOUR T1 - Comparison of approaches for rational siRNA design leading to a new efficient and transparent method AN - 20133871; 7420653 AB - Current literature describes several methods for the design of efficient siRNAs with 19 perfectly matched base pairs and 2 nt overhangs. Using four independent databases totaling 3336 experimentally verified siRNAs, we compared how well several of these methods predict siRNA cleavage efficiency. According to receiver operating characteristics (ROC) and correlation analyses, the best programs were BioPredsi, ThermoComposition and DSIR. We also studied individual parameters that significantly and consistently correlated with siRNA efficacy in different databases. As a result of this work we developed a new method which utilizes linear regression fitting with local duplex stability, nucleotide position-dependent preferences and total G/C content of siRNA duplexes as input parameters. The new method's discrimination ability of efficient and inefficient siRNAs is comparable with that of the best methods identified, but its parameters are more obviously related to the mechanisms of siRNA action in comparison with BioPredsi. This permits insight to the underlying physical features and relative importance of the parameters. The new method of predicting siRNA efficiency is faster than that of ThermoComposition because it does not employ time-consuming RNA secondary structure calculations and has much less parameters than DSIR. It is available as a web tool called 'siRNA scales'. JF - Nucleic Acids Research AU - Matveeva, Olga AU - Nechipurenko, Yury AU - Rossi, Leo AU - Moore, Barry AU - Saetrom, Paal AU - Ogurtsov, Aleksey Y AU - Atkins, John F AU - Shabalina, Svetlana A AD - Department of Human Genetics, University of Utah, Salt Lake City 84112-5330, USA, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Ul. Vavilova 32, 119991 Moscow, Russia, Department of Computer and Information Science, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway, National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894, USA and Bioscience Institute, University College Cork, Cork, Ireland Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - e63 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 35 IS - 8 SN - 0305-1048, 0305-1048 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Protein structure KW - Databases KW - Computer programs KW - siRNA KW - Secondary structure KW - Correlation analysis KW - Nucleotides KW - Base pairs KW - N 14830:RNA KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20133871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Comparison+of+approaches+for+rational+siRNA+design+leading+to+a+new+efficient+and+transparent+method&rft.au=Matveeva%2C+Olga%3BNechipurenko%2C+Yury%3BRossi%2C+Leo%3BMoore%2C+Barry%3BSaetrom%2C+Paal%3BOgurtsov%2C+Aleksey+Y%3BAtkins%2C+John+F%3BShabalina%2C+Svetlana+A&rft.aulast=Matveeva&rft.aufirst=Olga&rft.date=2007-04-01&rft.volume=35&rft.issue=8&rft.spage=e63&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Protein structure; Computer programs; Databases; siRNA; Secondary structure; Correlation analysis; Nucleotides; Base pairs ER - TY - JOUR T1 - Multiplexing siRNAs to compress RNAi-based screen size in human cells AN - 20096658; 7420647 AB - Here we describe a novel strategy using multiplexes of synthetic small interfering RNAs (siRNAs) corresponding to multiple gene targets in order to compress RNA interference (RNAi) screen size. Before investigating the practical use of this strategy, we first characterized the gene-specific RNAi induced by a large subset (258 siRNAs, 129 genes) of the entire siRNA library used in this study ( similar to 800 siRNAs, similar to 400 genes). We next demonstrated that multiplexed siRNAs could silence at least six genes to the same degree as when the genes were targeted individually. The entire library was then used in a screen in which randomly multiplexed siRNAs were assayed for their affect on cell viability. Using this strategy, several gene targets that influenced the viability of a breast cancer cell line were identified. This study suggests that the screening of randomly multiplexed siRNAs may provide an important avenue towards the identification of candidate gene targets for downstream functional analyses and may also be useful for the rapid identification of positive controls for use in novel assay systems. This approach is likely to be especially applicable where assay costs or platform limitations are prohibitive. JF - Nucleic Acids Research AU - Martin, Scott E AU - Jones, Tamara L AU - Thomas, Cheryl L AU - Lorenzi, Philip L AU - Nguyen, Dac A AU - Runfola, Timothy AU - Gunsior, Michele AU - Weinstein, John N AU - Goldsmith, Paul K AU - Lader, Eric AU - Huppi, Konrad AU - Caplen, Natasha J AD - Gene Silencing Section, Office of Science and Technology Partnership, OD, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Molecular Target Development Program, CCR, NCI-Frederick, NIH, Frederick, Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, Antibody and Protein Purification Unit, CCR, NCI, NIH, Bethesda and Qiagen Inc., Germantown, MD, USA Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - e57 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 35 IS - 8 SN - 0305-1048, 0305-1048 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Tumor cell lines KW - siRNA KW - RNA-mediated interference KW - Breast cancer KW - W 30905:Medical Applications KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20096658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Multiplexing+siRNAs+to+compress+RNAi-based+screen+size+in+human+cells&rft.au=Martin%2C+Scott+E%3BJones%2C+Tamara+L%3BThomas%2C+Cheryl+L%3BLorenzi%2C+Philip+L%3BNguyen%2C+Dac+A%3BRunfola%2C+Timothy%3BGunsior%2C+Michele%3BWeinstein%2C+John+N%3BGoldsmith%2C+Paul+K%3BLader%2C+Eric%3BHuppi%2C+Konrad%3BCaplen%2C+Natasha+J&rft.aulast=Martin&rft.aufirst=Scott&rft.date=2007-04-01&rft.volume=35&rft.issue=8&rft.spage=e57&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Tumor cell lines; siRNA; Breast cancer; RNA-mediated interference ER - TY - JOUR T1 - Occupational benzene exposure from vehicular sources in India and its effect on hematology, lymphocyte subsets and platelet P-selectin expression AN - 19998495; 7965783 AB - Benzene exposure from vehicular sources and its health impact are relatively unexplored in India. We have investigated in this study hematology and lymphocyte subsets of 25 petrol pump attendants, 25 automobile service station workers and 35 controls matched for age, sex and socioeconomic conditions. The participants were non-smoking males of Kolkata (former Calcutta) in eastern India. Compared with controls, the workers had 3.8- times more trans, trans-muconic acid in urine, suggesting higher level of benzene exposure. The exposed subjects had decreased erythrocyte, hemoglobin, lymphocyte and platelet levels, but increased neutrophil, band cells, RBC aniso-poikilocytosis and target cells. In addition, CD4+, CD8+ and CD19+ cells were decreased by 37, 20 and 47% respectively, but CD 16+56+ NK cells were increased by 20%. P-selectin expression on platelet surface of the workers was significantly elevated (P < 0.05), indicating upregulation of platelet activity. In summary, the study revealed high level of benzene exposure from vehicular sources in India, and the exposed subjects had hematological and immunological alterations. JF - Toxicology and Industrial Health AU - Ray, M R AU - Roychoudhury, S AU - Mukherjee, S AU - Lahiri, T AD - Experimental Hematology Unit, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata 700 026, India, manasrray@rediffmail.com Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 167 EP - 175 VL - 23 IS - 3 SN - 0748-2337, 0748-2337 KW - Immunology Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - Age KW - Motor vehicles KW - Erythrocytes KW - Socioeconomics KW - P-selectin KW - Lymphocytes KW - Benzene KW - India KW - Hemoglobin KW - Workers KW - CD4 antigen KW - Hematology KW - Cadmium KW - Occupational exposure KW - Sex KW - India, West Bengal, Calcutta Dist., Calcutta KW - Leukocytes (neutrophilic) KW - Natural killer cells KW - CD8 antigen KW - Socio-economic aspects KW - Urine KW - Platelets KW - Pumps KW - F 06955:Immunomodulation & Immunopharmacology KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19998495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Occupational+benzene+exposure+from+vehicular+sources+in+India+and+its+effect+on+hematology%2C+lymphocyte+subsets+and+platelet+P-selectin+expression&rft.au=Ray%2C+M+R%3BRoychoudhury%2C+S%3BMukherjee%2C+S%3BLahiri%2C+T&rft.aulast=Ray&rft.aufirst=M&rft.date=2007-04-01&rft.volume=23&rft.issue=3&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/10.1177%2F0748233707080907 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Motor vehicles; Erythrocytes; Natural killer cells; Leukocytes (neutrophilic); P-selectin; Lymphocytes; CD8 antigen; Benzene; Hemoglobin; Socio-economic aspects; Workers; CD4 antigen; Urine; Platelets; Occupational exposure; Sex; Age; Socioeconomics; Cadmium; Pumps; Hematology; India, West Bengal, Calcutta Dist., Calcutta; India DO - http://dx.doi.org/10.1177/0748233707080907 ER - TY - JOUR T1 - Side Population Analysis Using a Violet-Excited Cell-Permeable DNA Binding Dye AN - 19998432; 7410036 AB - Hoechst 33342 side population (SP) analysis is a common method for identifying stem cells in mammalian hematopoietic and nonhematopoietic tissues. Although widely employed for stem cell analysis, this method requires an ultraviolet (UV) laser to excite Hoechst 33342. Flow cytometers equipped with UV sources are not common because of the cost of both the laser and optics that can transmit light UV light. Violet laser sources are inexpensive and are now common fixtures on flow cytometers, but have been previously shown to provide insufficient Hoechst dye excitation for consistent resolution of SP cells. One solution to this problem is to identify additional fluorescent substrates with the same pump specificity as Hoechst 33342, but with better violet excitation characteristics. DyeCycle Violet reagent has emission characteristics similar to those of Hoechst 33342, but with a longer wavelength excitation maxima (369 nm). When this dye is loaded into hematopoietic cells, a sharply resolved side population was also observed, similar in appearance to that seen with Hoechst 33342. Unlike Hoechst SP, DCV SP was similar in appearance with both violet and UV excitation. DCV SP could be inhibited fumitremorgin C, and showed the same membrane pump specificity as Hoechst 33342. Simultaneous immunophenotyping with stem cell markers in mouse bone marrow demonstrated that DCV SP was restricted to the stem cell lineage super(-) Sca-1 super(+) c-kit super(+) cells population, as is Hoechst SP. Pending confirmation by functional analysis of DCV SP cells, these results suggest that DCV efflux identified approximately the same stem cell population as did Hoechst 33342 efflux. Substituting DCV for Hoechst 33342 in the SP technique may, therefore, allow side population analysis on flow cytometers with violet lasers. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Telford, William G AU - Bradford, Jolene AU - Godfrey, William AU - Robey, Robert W AU - Bates, Susan E AD - Experimental Transplantation and Immunology Branch and Cancer Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Molecular Probes Invitrogen, Eugene, Oregon, USA Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 1029 EP - 1036 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 25 IS - 4 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Optics KW - Stem cells KW - U.V. radiation KW - Bone marrow KW - DNA KW - Hemopoiesis KW - Lasers KW - Wavelength KW - W 30940:Products KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19998432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Side+Population+Analysis+Using+a+Violet-Excited+Cell-Permeable+DNA+Binding+Dye&rft.au=Telford%2C+William+G%3BBradford%2C+Jolene%3BGodfrey%2C+William%3BRobey%2C+Robert+W%3BBates%2C+Susan+E&rft.aulast=Telford&rft.aufirst=William&rft.date=2007-04-01&rft.volume=25&rft.issue=4&rft.spage=1029&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Optics; Stem cells; U.V. radiation; DNA; Bone marrow; Hemopoiesis; Lasers; Wavelength ER - TY - JOUR T1 - A dendrimer-based nanosized contrast agent dual-labeled for magnetic resonance and optical fluorescence imaging to localize the sentinel lymph node in mice AN - 19990985; 7459399 AB - To preoperatively and intraoperatively localize the sentinel lymph node (SLN), a single hybrid probe for MR and near infrared (NIR) optical imaging was synthesized and tested. A macromolecular MR/NIR optical contrast agent was synthesized based on a [sim]191 gadolinium-labeled contrast agent using generation-6 polyamidoamine dendrimer (G6), which is also labeled with 2 Cy5.5, an NIR fluorophore. After establishing the optimal dose, the agent was injected into mammary glands of 10 normal mice to examine the lymphatic drainage from the breast using a 3T clinical scanner. Immediately after the MRI scan, NIR optical imaging and image-guided surgery were performed to compare the two imaging modalities. To consistently identify the SLNs, we needed to inject 25 [mu]L of 30 mM [Gd] G6-Cy5.5. All SLNs could be easily identified and resected under NIR optical imaging-guided surgery. Although external NIR optical imaging failed to identify SLNs close to the injection site due to shinethrough, MR lymphography (MRL) consistently identified all SLNs regardless of their location. We have successfully synthesized and tested a dual labeled MR/NIR optical hybrid contrast agent, G6-Cy5.5 for reoperative and intraoperative localization of SLNs. J. Magn. Reson. Imaging 2007. JF - Journal of Magnetic Resonance Imaging AU - Koyama, Yoshinori AU - Talanov, Vladimir S AU - Bernardo, Marcelino AU - Hama, Yukihiro AU - Regino, Celeste AS AU - Brechbiel, Martin W AU - Choyke, Peter L AU - Kobayashi, Hisataka AD - Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA, Kobayash@mail.nih.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 866 EP - 871 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 25 IS - 4 SN - 1053-1807, 1053-1807 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - sentinel lymph node KW - MRI KW - near infrared optical imaging KW - hybrid probe KW - macromolecular contrast agent KW - nanotechnology KW - Macromolecules KW - Fluorescence KW - Mammary gland KW - Drainage KW - Breast KW - polyamidoamines KW - Magnetic resonance imaging KW - Probes KW - fluorophores KW - Lymph nodes KW - Hybrids KW - Surgery KW - Contrast media KW - Lymphography KW - N.M.R. KW - W 30910:Imaging KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19990985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Magnetic+Resonance+Imaging&rft.atitle=A+dendrimer-based+nanosized+contrast+agent+dual-labeled+for+magnetic+resonance+and+optical+fluorescence+imaging+to+localize+the+sentinel+lymph+node+in+mice&rft.au=Koyama%2C+Yoshinori%3BTalanov%2C+Vladimir+S%3BBernardo%2C+Marcelino%3BHama%2C+Yukihiro%3BRegino%2C+Celeste+AS%3BBrechbiel%2C+Martin+W%3BChoyke%2C+Peter+L%3BKobayashi%2C+Hisataka&rft.aulast=Koyama&rft.aufirst=Yoshinori&rft.date=2007-04-01&rft.volume=25&rft.issue=4&rft.spage=866&rft.isbn=&rft.btitle=&rft.title=Journal+of+Magnetic+Resonance+Imaging&rft.issn=10531807&rft_id=info:doi/10.1002%2Fjmri.20852 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Macromolecules; Fluorescence; Mammary gland; Drainage; Magnetic resonance imaging; polyamidoamines; Breast; Probes; fluorophores; Lymph nodes; Surgery; Hybrids; Contrast media; Lymphography; N.M.R. DO - http://dx.doi.org/10.1002/jmri.20852 ER - TY - JOUR T1 - Cytotoxic T Cell-Mediated Diabetes in RIP-CD80 Transgenic Mice AN - 19891191; 7910313 AB - AbstractRodent immune-mediated diabetes model studies have advanced understanding of beta cell-specific T cell responses, and the testing of therapeutic approaches. We have used an inducible diabetes model based on rat insulin promotor (RIP)-driven expression of CD80 (B7-1) on pancreatic beta cells. Using these mice, we have established that immunizing with a single autoantigen can promote progressive islet inflammation and eventually T cell-mediated diabetes. We now describe a potent immunization protocol using peptide-pulsed mature dendritic cells (DCs) to examine peptide epitopes derived from endogenous (preproinsulin) and transgenically expressed beta cell antigens, namely lymphocytic choriomeningitis virus glycoprotein (LCMV-GP). LCMV-GP epitopes efficiently promote beta cell destruction, and the autoantigenic peptide concentration used to load the DCs correlates directly with diabetes onset. The system allowed us to assess cytotoxic T cell (CTL) fine specificity by immunizing with DCs presenting altered peptide ligands (APLs) of the dominant LCMV-GP epitope, gp33. Finally, using an adoptive transfer system, we tested alternative in vitro T cell activation conditions, including APLs and mitogens, for their impact on T cell effector function and diabetes onset. Our studies revealed a marked discrepancy between (inflammatory) effector functions and diabetes progression, thus emphasizing the importance of structural identity between sensitizing and target epitope and the context of initial T cell activation. JF - Annals of the New York Academy of Sciences AU - PECHHOLD, KLAUS AU - Chakrabarty, Sagarika AU - Harlan, David M AD - Diabetes Branch, NIDDK, NIH, DHHS, Bethesda Maryland, USA, KlausP@intra.niddk.nih.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 132 EP - 142 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 1103 IS - 1 SN - 0077-8923, 0077-8923 KW - Virology & AIDS Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - autoantigen-induced diabetes KW - altered peptide ligands KW - transgenic mouse KW - cytotoxic T lymphocytes KW - immunization KW - autoimmunity KW - Pancreas KW - Preproinsulin KW - Animal models KW - Beta cells KW - Islets of Langerhans KW - Transgenic mice KW - Autoantigens KW - Insulin KW - Immunization KW - Inflammation KW - Cell activation KW - Lymphocytic choriomeningitis virus KW - Diabetes mellitus KW - Dendritic cells KW - B7-1 antigen KW - Cytotoxicity KW - Lymphocytes T KW - Adoptive transfer KW - Mitogens KW - CD80 antigen KW - Glycoproteins KW - Epitopes KW - W 30925:Genetic Engineering KW - V 22350:Immunology KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19891191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Cytotoxic+T+Cell-Mediated+Diabetes+in+RIP-CD80+Transgenic+Mice&rft.au=PECHHOLD%2C+KLAUS%3BChakrabarty%2C+Sagarika%3BHarlan%2C+David+M&rft.aulast=PECHHOLD&rft.aufirst=KLAUS&rft.date=2007-04-01&rft.volume=1103&rft.issue=1&rft.spage=132&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1196%2Fannals.1394.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Pancreas; Preproinsulin; Animal models; Beta cells; Islets of Langerhans; Transgenic mice; Immunization; Insulin; Autoantigens; Cell activation; Inflammation; Diabetes mellitus; B7-1 antigen; Dendritic cells; Cytotoxicity; Adoptive transfer; Lymphocytes T; CD80 antigen; Mitogens; Glycoproteins; Epitopes; Lymphocytic choriomeningitis virus DO - http://dx.doi.org/10.1196/annals.1394.008 ER - TY - JOUR T1 - Transmission and Adaptation of Chronic Wasting Disease to Hamsters and Transgenic Mice: Evidence for Strains AN - 19876964; 7408371 AB - In vitro screening using the cell-free prion protein conversion system indicated that certain rodents may be susceptible to chronic wasting disease (CWD). Therefore, CWD isolates from mule deer, white-tailed deer, and elk were inoculated intracerebrally into various rodent species to assess the rodents' susceptibility and to develop new rodent models of CWD. The species inoculated were Syrian golden, Djungarian, Chinese, Siberian, and Armenian hamsters, transgenic mice expressing the Syrian golden hamster prion protein, and RML Swiss and C57BL10 wild-type mice. The transgenic mice and the Syrian golden, Chinese, Siberian, and Armenian hamsters had limited susceptibility to certain of the CWD inocula, as evidenced by incomplete attack rates and long incubation periods. For serial passages of CWD isolates in Syrian golden hamsters, incubation periods rapidly stabilized, with isolates having either short (85 to 89 days) or long (408 to 544 days) mean incubation periods and distinct neuropathological patterns. In contrast, wild-type mouse strains and Djungarian hamsters were not susceptible to CWD. These results show that CWD can be transmitted and adapted to some species of rodents and suggest that the cervid-derived CWD inocula may have contained or diverged into at least two distinct transmissible spongiform encephalopathy strains. JF - Journal of Virology AU - Raymond, Gregory J AU - Raymond, Lynne D AU - Meade-White, Kimberly D AU - Hughson, Andrew G AU - Favara, Cynthia AU - Gardner, Donald AU - Williams, Elizabeth S AU - Miller, Michael W AU - Race, Richard E AU - Caughey, Byron AD - Laboratory of Persistent Viral Diseases. Rocky Mountain Veterinary Branch, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, Montana 59840. Department of Veterinary Sciences, University of Wyoming, Laramie, Wyoming 82070. Colorado Division of Wildlife, Wildlife Research Center, Fort Collins, Colorado 80526-2097 Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 4305 EP - 4314 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 81 IS - 8 SN - 0022-538X, 0022-538X KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Virology & AIDS Abstracts KW - Transmissible spongiform encephalopathy KW - Adaptations KW - Neurotransmission KW - Prion protein KW - Animal models KW - Transgenic mice KW - Chronic wasting disease KW - W 30925:Genetic Engineering KW - N3 11027:Neurology & neuropathology KW - V 22380:Prions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19876964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Transmission+and+Adaptation+of+Chronic+Wasting+Disease+to+Hamsters+and+Transgenic+Mice%3A+Evidence+for+Strains&rft.au=Raymond%2C+Gregory+J%3BRaymond%2C+Lynne+D%3BMeade-White%2C+Kimberly+D%3BHughson%2C+Andrew+G%3BFavara%2C+Cynthia%3BGardner%2C+Donald%3BWilliams%2C+Elizabeth+S%3BMiller%2C+Michael+W%3BRace%2C+Richard+E%3BCaughey%2C+Byron&rft.aulast=Raymond&rft.aufirst=Gregory&rft.date=2007-04-01&rft.volume=81&rft.issue=8&rft.spage=4305&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Transmissible spongiform encephalopathy; Adaptations; Neurotransmission; Animal models; Prion protein; Transgenic mice; Chronic wasting disease ER - TY - JOUR T1 - Worldwide Occurrence of Feline Hemoplasma Infections in Wild Felid Species AN - 19876050; 7407426 AB - While hemoplasma infections in domestic cats are well studied, almost no information is available on their occurrence in wild felids. The aims of the present study were to investigate wild felid species as possible reservoirs of feline hemoplasmas and the molecular characterization of the hemoplasma isolates. Blood samples from the following 257 wild felids were analyzed: 35 Iberian lynxes from Spain, 36 Eurasian lynxes from Switzerland, 31 European wildcats from France, 45 lions from Tanzania, and 110 Brazilian wild felids, including 12 wild felid species kept in zoos and one free-ranging ocelot. Using real-time PCR, feline hemoplasmas were detected in samples of the following species: Iberian lynx, Eurasian lynx, European wildcat, lion, puma, oncilla, Geoffroy's cat, margay, and ocelot. "Candidatus Mycoplasma haemominutum" was the most common feline hemoplasma in Iberian lynxes, Eurasian lynxes, Serengeti lions, and Brazilian wild felids, whereas "Candidatus Mycoplasma turicensis" was the most prevalent in European wildcats; hemoplasma coinfections were frequently observed. Hemoplasma infection was associated with species and free-ranging status of the felids in all animals and with feline leukemia virus provirus-positive status in European wildcats. Phylogenetic analyses of the 16S rRNA and the partial RNase P gene revealed that most hemoplasma isolates exhibit high sequence identities to domestic cat-derived isolates, although some isolates form different subclusters within the phylogenetic tree. In conclusion, 9 out of 15 wild felid species from three different continents were found to be infected with feline hemoplasmas. The effect of feline hemoplasma infections on wild felid populations needs to be further investigated. JF - Journal of Clinical Microbiology AU - Willi, Barbara AU - Filoni, Claudia AU - Catao-Dias, Jose L AU - Cattori, Valentino AU - Meli, Marina L AU - Vargas, Astrid AU - Martinez, Fernando AU - Roelke, Melody E AU - Ryser-Degiorgis, Marie-Pierre AU - Leutenegger, Christian M AU - Lutz, Hans AU - Hofmann-Lehmann, Regina AD - Clinical Laboratory, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland. Departamento de Patologia, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Brazil. Instituto Brasileiro para Medicina da Conservacao-TRIADE, Brazil. Fundacao Parque Zoologico de Sao Paulo, Brazil. Centro de Cria de Lince Iberico, El Acebuche, Donana National Park, Matalascanas, Spain. Laboratory of Genomic Diversity, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702. Centre for Fish and Wildlife Health, Institute of Animal Pathology, Vetsuisse Faculty, University of Berne, Berne, Switzerland. Department of Medicine and Epidemiology, University of California, Davis, California Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 1159 EP - 1166 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 45 IS - 4 SN - 0095-1137, 0095-1137 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology KW - Lynx KW - Phylogeny KW - Mycoplasma haemominutum KW - Feline leukemia virus KW - Polymerase chain reaction KW - Infection KW - Feline leukemia KW - rRNA 16S KW - Mycoplasma KW - Ribonuclease P KW - J 02310:Genetics & Taxonomy KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19876050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Worldwide+Occurrence+of+Feline+Hemoplasma+Infections+in+Wild+Felid+Species&rft.au=Willi%2C+Barbara%3BFiloni%2C+Claudia%3BCatao-Dias%2C+Jose+L%3BCattori%2C+Valentino%3BMeli%2C+Marina+L%3BVargas%2C+Astrid%3BMartinez%2C+Fernando%3BRoelke%2C+Melody+E%3BRyser-Degiorgis%2C+Marie-Pierre%3BLeutenegger%2C+Christian+M%3BLutz%2C+Hans%3BHofmann-Lehmann%2C+Regina&rft.aulast=Willi&rft.aufirst=Barbara&rft.date=2007-04-01&rft.volume=45&rft.issue=4&rft.spage=1159&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Phylogeny; Polymerase chain reaction; Feline leukemia; Infection; rRNA 16S; Ribonuclease P; Lynx; Mycoplasma haemominutum; Feline leukemia virus; Mycoplasma ER - TY - JOUR T1 - Identification of a Highly Effective Rapamycin Schedule that Markedly Reduces the Size, Multiplicity, and Phenotypic Progression of Tobacco Carcinogen-Induced Murine Lung Tumors AN - 19873800; 7405269 AB - PURPOSE: Human and murine preneoplastic lung lesions induced by tobacco exposure are characterized by increased activation of the Akt/mammalian target of rapamycin (mTOR) pathway, suggesting a role for this pathway in lung cancer development. To test this, we did studies with rapamycin, an inhibitor of mTOR, in A/J mice that had been exposed to the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Experimental Design: Tumorigenesis was induced by i.p. injection of NNK, and rapamycin was administered 1 or 26 weeks after NNK administration. Biomarkers associated with mTOR inhibition were assessed in lung and/or surrogate tissues using immunohistochemistry and immunoblotting. Rapamycin levels were measured using mass spectroscopy. RESULTS: Rapamycin was administered on a daily (5 of 7 days) regimen beginning 26 weeks after NNK decreased tumor size, proliferative rate, and mTOR activity. Multiplicity was not affected. Comparing this regimen with an every-other-day (qod) regimen revealed that rapamycin levels were better maintained with qod administration, reaching a nadir of 16.4 ng/mL, a level relevant in humans. When begun 1 week after NNK, this regimen was well tolerated and decreased tumor multiplicity by 90%. Tumors that did develop showed decreased phenotypic progression and a 74% decrease in size that correlated with decreased proliferation and inhibition of mTOR. CONCLUSIONS: Tobacco carcinogen-induced lung tumors in A/J mice are dependent upon mTOR activity because rapamycin markedly reduced the development and growth of tumors. Combined with the Food and Drug Administration approval of rapamycin and broad clinical experience, these studies provide a rationale to assess rapamycin in trials with smokers at high risk to develop lung cancer. JF - Clinical Cancer Research AU - Granville, Courtney A AU - Warfel, Noel AU - Tsurutani, Junji AU - Hollander, MChristine AU - Robertson, Matthew AU - Fox, Stephen D AU - Veenstra, Timothy D AU - Issaq, Haleem J AU - Linnoila, RIlona AU - Dennis, Phillip A AD - Authors' Affiliations: Medical Oncology Branch and Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland Y1 - 2007/04/01/ PY - 2007 DA - 2007 Apr 01 SP - 2281 EP - 2289 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 13 IS - 7 SN - 1078-0432, 1078-0432 KW - Toxicology Abstracts KW - Immunoblotting KW - Tumorigenesis KW - Carcinogens KW - Clinical trials KW - biomarkers KW - Risk factors KW - AKT protein KW - Tobacco KW - 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone KW - TOR protein KW - Immunohistochemistry KW - Rapamycin KW - Lung cancer KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19873800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Identification+of+a+Highly+Effective+Rapamycin+Schedule+that+Markedly+Reduces+the+Size%2C+Multiplicity%2C+and+Phenotypic+Progression+of+Tobacco+Carcinogen-Induced+Murine+Lung+Tumors&rft.au=Granville%2C+Courtney+A%3BWarfel%2C+Noel%3BTsurutani%2C+Junji%3BHollander%2C+MChristine%3BRobertson%2C+Matthew%3BFox%2C+Stephen+D%3BVeenstra%2C+Timothy+D%3BIssaq%2C+Haleem+J%3BLinnoila%2C+RIlona%3BDennis%2C+Phillip+A&rft.aulast=Granville&rft.aufirst=Courtney&rft.date=2007-04-01&rft.volume=13&rft.issue=7&rft.spage=2281&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Immunoblotting; Tumorigenesis; Carcinogens; biomarkers; Clinical trials; Risk factors; Tobacco; AKT protein; 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone; TOR protein; Immunohistochemistry; Rapamycin; Lung cancer ER - TY - JOUR T1 - Persistent Dopamine Functions of Neurons Derived from Embryonic Stem Cells in a Rodent Model of Parkinson Disease AN - 19779640; 7410055 AB - The derivation of dopamine neurons is one of the best examples of the clinical potential of embryonic stem (ES) cells, but the long-term function of the grafted neurons has not been established. Here, we show that, after transplantation into an animal model, neurons derived from mouse ES cells survived for over 32 weeks, maintained midbrain markers, and had sustained behavioral effects. Microdialysis in grafted animals showed that dopamine (DA) release was induced by depolarization and pharmacological stimulants. Positron emission tomography measured the expression of presynaptic dopamine transporters in the graft and also showed that the number of postsynaptic DA D sub(2) receptors was normalized in the host striatum. These data suggest that ES cell-derived neurons show DA release and reuptake and stimulate appropriate postsynaptic responses for long periods after implantation. This work supports continued interest in ES cells as a source of functional DA neurons. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Rodriguez-Gomez, Jose A AU - Lu, Jian-Qiang AU - Velasco, Ivan AU - Rivera, Seth AU - Zoghbi, Sami S AU - Liow, Jeih-San AU - Musachio, John L AU - Chin, Frederick T AU - Toyama, Hiroshi AU - Seidel, Jurgen AU - Green, Michael V AU - Thanos, Panayotis K AU - Ichise, Masanori AU - Pike, Victor W AU - Innis, Robert B AU - McKay, Ron DG AD - Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, Porter Neuroscience Research Center. Molecular Imaging Branch, National Institute of Mental Health. Clinical Center, National Institutes of Health, Bethesda, Maryland, USA. Medical Department, Brookhaven National Laboratory, Upton, New York, USA. Laboratory of Neuroimaging, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 918 EP - 928 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 25 IS - 4 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Dopamine D2 receptors KW - Transplantation KW - Data processing KW - Parkinson's disease KW - Animal models KW - Stimulants KW - Dopamine receptors KW - Microdialysis KW - Neurodegenerative diseases KW - Mesencephalon KW - Dopamine transporter KW - Stem cells KW - Movement disorders KW - Embryo cells KW - Neurons KW - Neostriatum KW - Positron emission tomography KW - N3 11001:Behavioral and Cognitive Neuroscience KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19779640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Persistent+Dopamine+Functions+of+Neurons+Derived+from+Embryonic+Stem+Cells+in+a+Rodent+Model+of+Parkinson+Disease&rft.au=Rodriguez-Gomez%2C+Jose+A%3BLu%2C+Jian-Qiang%3BVelasco%2C+Ivan%3BRivera%2C+Seth%3BZoghbi%2C+Sami+S%3BLiow%2C+Jeih-San%3BMusachio%2C+John+L%3BChin%2C+Frederick+T%3BToyama%2C+Hiroshi%3BSeidel%2C+Jurgen%3BGreen%2C+Michael+V%3BThanos%2C+Panayotis+K%3BIchise%2C+Masanori%3BPike%2C+Victor+W%3BInnis%2C+Robert+B%3BMcKay%2C+Ron+DG&rft.aulast=Rodriguez-Gomez&rft.aufirst=Jose&rft.date=2007-04-01&rft.volume=25&rft.issue=4&rft.spage=918&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Dopamine D2 receptors; Data processing; Transplantation; Parkinson's disease; Animal models; Stimulants; Dopamine receptors; Microdialysis; Mesencephalon; Neurodegenerative diseases; Stem cells; Dopamine transporter; Movement disorders; Embryo cells; Neurons; Neostriatum; Positron emission tomography ER - TY - JOUR T1 - The Nernst equation applied to oxidation-reduction reactions in myoglobin and hemoglobin. Evaluation of the parameters AN - 19760490; 7582958 AB - Analyses of the binding of oxygen to monomers such as myoglobin employ the Mass Action equation. The Mass Action equation, as such, is not directly applicable for the analysis of the binding of oxygen to oligomers such as hemoglobin. When the binding of oxygen to hemoglobin is analyzed, models incorporating extensions of mass action are employed. Oxidation-reduction reactions of the heme group in myoglobin and hemoglobin involve the binding and dissociation of electrons. This reaction is described with the Nernst equation. The Nernst equation is applicable only to a monomeric species even if the number of electrons involved is greater than unity. To analyze the oxidation-reduction reaction in a molecule such as hemoglobin a model is required which incorporates extensions of the Nernst equation. This communication develops models employing the Nernst equation for oxidation-reduction reactions analogous to those employed for hemoglobin in the analysis of the oxygenation (binding of oxygen) reaction. JF - Biopolymers AU - Saroff, Harry A AD - Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, saroff@helix.nih.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 450 EP - 455 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 85 IS - 5-6 SN - 0006-3525, 0006-3525 KW - Biotechnology and Bioengineering Abstracts KW - Hemoglobin KW - Monomers KW - Oxygen KW - Molecular modelling KW - Mathematical models KW - Heme KW - Biopolymers KW - Communication KW - myoglobin KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19760490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biopolymers&rft.atitle=The+Nernst+equation+applied+to+oxidation-reduction+reactions+in+myoglobin+and+hemoglobin.+Evaluation+of+the+parameters&rft.au=Saroff%2C+Harry+A&rft.aulast=Saroff&rft.aufirst=Harry&rft.date=2007-04-01&rft.volume=85&rft.issue=5-6&rft.spage=450&rft.isbn=&rft.btitle=&rft.title=Biopolymers&rft.issn=00063525&rft_id=info:doi/10.1002%2Fbip.20652 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Monomers; Hemoglobin; Molecular modelling; Oxygen; Mathematical models; Heme; Communication; Biopolymers; myoglobin DO - http://dx.doi.org/10.1002/bip.20652 ER - TY - JOUR T1 - Identification of prion inhibitors by a fluorescence-polarization-based competitive binding assay AN - 19732454; 7536900 JF - Analytical Biochemistry AU - Kocisko, David A AU - Bertholet, Nadine AU - Moore, Roger A AU - Caughey, Byron AU - Vaillant, Andrew AD - Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, 59840 USA, availlant@replicor.com Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 154 EP - 156 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 363 IS - 1 SN - 0003-2697, 0003-2697 KW - Biotechnology and Bioengineering Abstracts KW - Prion protein KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19732454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Biochemistry&rft.atitle=Identification+of+prion+inhibitors+by+a+fluorescence-polarization-based+competitive+binding+assay&rft.au=Kocisko%2C+David+A%3BBertholet%2C+Nadine%3BMoore%2C+Roger+A%3BCaughey%2C+Byron%3BVaillant%2C+Andrew&rft.aulast=Kocisko&rft.aufirst=David&rft.date=2007-04-01&rft.volume=363&rft.issue=1&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Analytical+Biochemistry&rft.issn=00032697&rft_id=info:doi/10.1016%2Fj.ab.2006.11.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Prion protein DO - http://dx.doi.org/10.1016/j.ab.2006.11.007 ER - TY - JOUR T1 - Role of exposure to environmental chemicals in the developmental basis of disease and dysfunction AN - 19698652; 7497194 JF - Reproductive Toxicology AU - Heindel, J J AD - National Institute of Environmental Health Sciences, Department of Health and Human Service, 79 T.W. Alexander Drive, Building 4401 3rd Floor, Mail Drop: EC-23, Room 3413, Research Triangle Park, NC 27709, United States, heindelj@niehs.nih.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 257 EP - 259 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 23 IS - 3 SN - 0890-6238, 0890-6238 KW - Health & Safety Science Abstracts KW - Chemicals KW - Environmental health KW - Diseases KW - H 14000:Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19698652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+Toxicology&rft.atitle=Role+of+exposure+to+environmental+chemicals+in+the+developmental+basis+of+disease+and+dysfunction&rft.au=Heindel%2C+J+J&rft.aulast=Heindel&rft.aufirst=J&rft.date=2007-04-01&rft.volume=23&rft.issue=3&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Reproductive+Toxicology&rft.issn=08906238&rft_id=info:doi/10.1016%2Fj.reprotox.2007.01.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Chemicals; Environmental health; Diseases DO - http://dx.doi.org/10.1016/j.reprotox.2007.01.006 ER - TY - JOUR T1 - The Cytokine, Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF), Can Deliver Bcl-XL as an Extracellular Fusion Protein to Protect Cells from Apoptosis and Retain Differentiation Induction AN - 19658157; 7406910 AB - Bcl-XL, a member of the Bcl-2 protein family, is able to suppress cell death induced by diverse stimuli in many cell types, including hematopoietic cells. Human granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that promotes the proliferation and maturation of neutrophils, eosinophils, and macrophages from bone marrow progenitors. We fused GM-CSF to Bcl-XL and examined the capacity of this chimera to bind human cells through the GM-CSF receptor and prevent apoptosis. We found that the chimeric protein increased the proliferation of human monocytes in culture from 24 h until at least 72 h. In the presence of different apoptotic agents, GM-CSF-Bcl-XL protected cells from induced cell death and promoted proliferation, whereas GM-CSF alone was completely inhibited. In the presence of cytarabine, GM-CSF-Bcl-XL was able also to promote the differentiation of the CD34@@u+@ myeloid precursor whereas Lfn-Bcl-XL, lacking the GM-CSF domain-stimulated cell proliferation and not differentiation. We conclude that recombinant GM-CSF-Bcl-XL binds the GM-CSF receptor on human monocyte/macrophage cells and bone marrow progenitors inducing differentiation and allowing Bcl-XL entry into cells where it blocks cell death and allows amplified cell proliferation. This fully human fusion protein has potential to prevent monocytopenia and represents a new strategy for engineering anti-apoptotic therapeutics. JF - Journal of Biological Chemistry AU - Antignani, Antonella AU - Youle, Richard J AD - Biochemistry Section, Surgical Neurology Branch, NINDS, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 11246 EP - 11254 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 15 SN - 0021-9258, 0021-9258 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Macrophages KW - Apoptosis KW - Bone marrow KW - Cell culture KW - Leukocytes (eosinophilic) KW - Bcl-x protein KW - Differentiation KW - Osteoprogenitor cells KW - Cytokines KW - Bcl-2 protein KW - Monocytes KW - cytarabine KW - Leukocytes (neutrophilic) KW - Granulocyte-macrophage colony-stimulating factor KW - CD34 antigen KW - Chimeras KW - Hemopoiesis KW - Fusion protein KW - Cell proliferation KW - W 30905:Medical Applications KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19658157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=The+Cytokine%2C+Granulocyte-Macrophage+Colony-stimulating+Factor+%28GM-CSF%29%2C+Can+Deliver+Bcl-XL+as+an+Extracellular+Fusion+Protein+to+Protect+Cells+from+Apoptosis+and+Retain+Differentiation+Induction&rft.au=Antignani%2C+Antonella%3BYoule%2C+Richard+J&rft.aulast=Antignani&rft.aufirst=Antonella&rft.date=2007-04-01&rft.volume=282&rft.issue=15&rft.spage=11246&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Granulocyte-macrophage colony-stimulating factor; Differentiation; Bcl-x protein; Apoptosis; Cell proliferation; Cytokines; Bone marrow; Macrophages; Osteoprogenitor cells; Monocytes; Fusion protein; Leukocytes (eosinophilic); cytarabine; CD34 antigen; Cell culture; Chimeras; Bcl-2 protein; Leukocytes (neutrophilic); Hemopoiesis ER - TY - JOUR T1 - Standardization of Insulin Immunoassays: Report of the American Diabetes Association Workgroup AN - 19656347; 7405325 AB - BACKGROUND: Circulating insulin concentration in serum or plasma provides important information for the estimation of insulin secretion and insulin resistance. Currently, lack of standardization of insulin assays hinders efforts to achieve consistent measures for treatment guidelines. METHODS: A Workgroup convened by the American Diabetes Association evaluated 12 different commercial insulin methods from 9 manufacturers. RESULTS: The within-assay CVs ranged from 3.7% to 39.0%, with 7 of 10 assays having a CV ^,10.6%. The among-assay CVs ranged from 12% to 66%, with a median value of 24%. A common insulin reference preparation did not change the among-assay CV and failed to improve harmonization of results among assays. Results from 6 of 10 assays agreed within the total error of 32% that is allowable based on biological variability criteria. Seven of 10 assays recovered insulin added to a serum pool within 15.5% of the expected concentration. In 9 of 10 methods, there was <2% cross-reactivity with intact human proinsulin, and 8 of 10 methods had <3% cross-reactivity with split (32, 33) proinsulin. For 9 of 10 assays, the cross-reactivity of des (64, 65) proinsulin exceeded 40%. Overall, most assays had acceptable imprecision and specificity for insulin. CONCLUSION: The discordance in test results for commercial insulin reagent sets is likely multifactorial and will require a continuing effort to understand the differences and achieve the desired consistency and harmonization among commercial immunoassays. JF - Clinical Chemistry AU - Marcovina, Santica AU - Bowsher, Ronald R AU - Miller, WGreg AU - Staten, Myrlene AU - Myers, Gary AU - Caudill, Samuel P AU - Campbell, Scott E AU - Steffes, Michael W AD - Northwest Lipid Metabolism and Diabetes Research Laboratory, University of Washington, Seattle, WA. LINCO Diagnostic Services, St. Charles MO. B2S Consulting, Beech Grove, IN. Department of Pathology, Virginia Commonwealth University, Richmond, VA. National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD. Division of Laboratory Services, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA. American Diabetes Association, Alexandria, VA. Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota, Minneapolis, MN Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 711 EP - 716 PB - American Association for Clinical Chemistry, Inc. VL - 53 IS - 4 SN - 0009-9147, 0009-9147 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Cross-reactivity KW - Insulin KW - Diabetes mellitus KW - Standardization KW - Discordance KW - Immunoassays KW - F 06900:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19656347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Chemistry&rft.atitle=Standardization+of+Insulin+Immunoassays%3A+Report+of+the+American+Diabetes+Association+Workgroup&rft.au=Marcovina%2C+Santica%3BBowsher%2C+Ronald+R%3BMiller%2C+WGreg%3BStaten%2C+Myrlene%3BMyers%2C+Gary%3BCaudill%2C+Samuel+P%3BCampbell%2C+Scott+E%3BSteffes%2C+Michael+W&rft.aulast=Marcovina&rft.aufirst=Santica&rft.date=2007-04-01&rft.volume=53&rft.issue=4&rft.spage=711&rft.isbn=&rft.btitle=&rft.title=Clinical+Chemistry&rft.issn=00099147&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Insulin; Cross-reactivity; Standardization; Immunoassays; Diabetes mellitus; Discordance ER - TY - JOUR T1 - Analysis of Multiple Differing Copies of the 16S rRNA Gene in Five Clinical Isolates and Three Type Strains of Nocardia Species and Implications for Species Assignment AN - 19655659; 7407424 AB - Five clinical isolates of Nocardia that showed ambiguous bases within the variable region of the 16S rRNA gene sequence were evaluated for the presence of multiple copies of this gene. The type strains of three Nocardia species, Nocardia concava, Nocardia ignorata, and Nocardia yamanashiensis, which also showed ambiguous bases in the variable region, were also examined. Cloning experiments using an amplified region of the 16S rRNA that contains the variable region showed that each isolate possessed 16S rRNA genes with at least two different sequences. In addition, hybridization studies using a 16S rRNA gene-specific probe and extracted genomic DNA of the patient isolates and of the type strain of N. ignorata showed that each isolate possessed at least three copies of the gene. These multiple differing copies of the 16S rRNA gene and the results of DNA-DNA hybridization studies indicate problems of species definition and identification for such isolates. A broader species concept than that currently in vogue may be required to accommodate such organisms. JF - Journal of Clinical Microbiology AU - Conville, Patricia S AU - Witebsky, Frank G AD - Microbiology Service, Department of Laboratory Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, U.S. Department of Health and Human Services, 10 Center Drive, MSC 1508, Bethesda, Maryland 20882-1508 Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 1146 EP - 1151 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 45 IS - 4 SN - 0095-1137, 0095-1137 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Clinical isolates KW - DNA probes KW - genomics KW - Nocardia KW - rRNA 16S KW - Variable region KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19655659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Analysis+of+Multiple+Differing+Copies+of+the+16S+rRNA+Gene+in+Five+Clinical+Isolates+and+Three+Type+Strains+of+Nocardia+Species+and+Implications+for+Species+Assignment&rft.au=Conville%2C+Patricia+S%3BWitebsky%2C+Frank+G&rft.aulast=Conville&rft.aufirst=Patricia&rft.date=2007-04-01&rft.volume=45&rft.issue=4&rft.spage=1146&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Clinical isolates; DNA probes; genomics; rRNA 16S; Variable region; Nocardia ER - TY - JOUR T1 - The Human T-Box Mesodermal Transcription Factor Brachyury Is a Candidate Target for T-Cell-Mediated Cancer Immunotherapy AN - 19654890; 7405295 AB - PURPOSE: Identification of tumor antigens is essential in advancing immune-based therapeutic interventions in cancer. Particularly attractive targets are those molecules that are selectively expressed by malignant cells and that are also essential for tumor progression. Experimental Design and Results: We have used a computer-based differential display analysis tool for mining of expressed sequence tag clusters in the human Unigene database and identified Brachyury as a novel tumor antigen. Brachyury, a member of the T-box transcription factor family, is a key player in mesoderm specification during embryonic development. Moreover, transcription factors that control mesoderm have been implicated in the epithelial-mesenchymal transition (EMT), which has been postulated to be a key step during tumor progression to metastasis. Reverse transcription-PCR analysis validated the in silico predictions and showed Brachyury expression in tumors of the small intestine, stomach, kidney, bladder, uterus, ovary, and testis, as well as in cell lines derived from lung, colon, and prostate carcinomas, but not in the vast majority of the normal tissues tested. An HLA-A0201 epitope of human Brachyury was identified that was able to expand T lymphocytes from blood of cancer patients and normal donors with the ability to lyse Brachyury-expressing tumor cells. CONCLUSIONS: To our knowledge, this is the first demonstration that (a) a T-box transcription factor and (b) a molecule implicated in mesodermal development, i.e., EMT, can be a potential target for human T-cell-mediated cancer immunotherapy. JF - Clinical Cancer Research AU - Palena, Claudia AU - Polev, Dmitry E AU - Tsang, Kwong Y AU - Fernando, Romaine I AU - Litzinger, Mary AU - Krukovskaya, Larisa L AU - Baranova, Ancha V AU - Kozlov, Andrei P AU - Schlom, Jeffrey AD - Authors' Affiliations: Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 2471 EP - 2478 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 13 IS - 8 SN - 1078-0432, 1078-0432 KW - Brachyury protein KW - Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Testes KW - Histocompatibility antigen HLA KW - Immunotherapy KW - Therapeutic applications KW - Small intestine KW - expressed sequence tags KW - Tumor cells KW - Metastases KW - Colon KW - Lymphocytes T KW - Epitopes KW - Differential display KW - Uterus KW - Urinary bladder KW - Tumors KW - Cancer KW - Mesoderm KW - prostate carcinoma KW - Blood KW - Databases KW - Embryogenesis KW - Lung KW - Transcription factors KW - Antigen (tumor-associated) KW - Kidney KW - Ovaries KW - Stomach KW - F 06915:Cancer Immunology KW - N 14835:Protein-Nucleic Acids Association KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19654890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=The+Human+T-Box+Mesodermal+Transcription+Factor+Brachyury+Is+a+Candidate+Target+for+T-Cell-Mediated+Cancer+Immunotherapy&rft.au=Palena%2C+Claudia%3BPolev%2C+Dmitry+E%3BTsang%2C+Kwong+Y%3BFernando%2C+Romaine+I%3BLitzinger%2C+Mary%3BKrukovskaya%2C+Larisa+L%3BBaranova%2C+Ancha+V%3BKozlov%2C+Andrei+P%3BSchlom%2C+Jeffrey&rft.aulast=Palena&rft.aufirst=Claudia&rft.date=2007-04-01&rft.volume=13&rft.issue=8&rft.spage=2471&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Testes; Immunotherapy; Therapeutic applications; Small intestine; Tumor cells; expressed sequence tags; Metastases; Colon; Lymphocytes T; Differential display; Epitopes; Uterus; Urinary bladder; Tumors; Mesoderm; Cancer; prostate carcinoma; Databases; Blood; Embryogenesis; Lung; Transcription factors; Antigen (tumor-associated); Kidney; Ovaries; Stomach ER - TY - JOUR T1 - JNK1, but not JNK2, is required for COX-2 induction by nickel compounds AN - 19651188; 7404891 AB - Activation of the signaling pathways leading to gene expression regulation is critical in the carcinogenic effects of nickel exposure. In the present study, we found nickel exposure could induce cyclooxygenase-2 (COX-2) expression at transcriptional and protein levels in both human bronchoepithelial cells (Beas-2B) and murine embryonic fibroblasts (MEFs). We further provided direct evidence for the specific involvement of the JNK1 signaling pathway in the COX-2 induction using specific gene knockout approaches. Our results demonstrated that COX-2 induction by nickel was impaired in JNK1 super(-/-) MEFs, but not in JNK2 super(-/-) MEFs. Moreover, re-constitutional expression of JNK1 restored COX-2 induction, confirming the specific requirement of JNK1 in COX-2 induction. Further investigation revealed that JNK1 mediated the nickel-induced COX-2 expression in a c-Jun/AP-1-dependent manner. Ectopic expression of TAM67, a c-Jun dominant negative mutant, also suppressed the COX-2 induction. Our results demonstrate that the JNK1/c-Jun/AP-1 pathway, but not the JNK2 pathway, plays a critical role in nickel-induced COX-2 expression. JF - Carcinogenesis AU - Zhang, Dongyun AU - Li, Jingxia AU - Wu, Kangjian AU - Ouyang, Weiming AU - Ding, Jin AU - Liu, Zheng-gang AU - Costa, Max AU - Huang, Chuanshu AD - Nelson Institute of Environmental Medicine, New York University School of Medicine 57 Old Forge Road, Tuxedo, NY 10987, USA. Cell and Cancer Biology Branch, Center for Cancer Research NCI, National Institutes of Health, Bethesda, MD 20892, USA Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 883 EP - 891 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 28 IS - 4 SN - 0143-3334, 0143-3334 KW - Oncogenes & Growth Factors Abstracts; Toxicology Abstracts KW - Cyclooxygenase-2 KW - Gene expression KW - Transcription factors KW - Nickel KW - Carcinogenesis KW - Embryo fibroblasts KW - c-Jun protein KW - Signal transduction KW - B 26660:Miscellaneous Oncogenes & Growth Factors KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19651188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=JNK1%2C+but+not+JNK2%2C+is+required+for+COX-2+induction+by+nickel+compounds&rft.au=Zhang%2C+Dongyun%3BLi%2C+Jingxia%3BWu%2C+Kangjian%3BOuyang%2C+Weiming%3BDing%2C+Jin%3BLiu%2C+Zheng-gang%3BCosta%2C+Max%3BHuang%2C+Chuanshu&rft.aulast=Zhang&rft.aufirst=Dongyun&rft.date=2007-04-01&rft.volume=28&rft.issue=4&rft.spage=883&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gene expression; Cyclooxygenase-2; Transcription factors; Embryo fibroblasts; Carcinogenesis; Nickel; c-Jun protein; Signal transduction ER - TY - JOUR T1 - Activatable Fluorescent Molecular Imaging of Peritoneal Metastases following Pretargeting with a Biotinylated Monoclonal Antibody AN - 19650492; 7404855 AB - Optical probes that yield high target-to-background ratios are necessary to detect microfoci of cancer that would otherwise escape detection with white light imaging. Target-specific activation of the optical signal at tumor foci is one mechanism by which high target and low background signal can be achieved. Here, we describe a two-step activation process in which the tumors are first pretargeted with a nonfluorescent biotinylated monoclonal antibody [cetuximab (Erbitux) targeting human epidermal growth factor receptor type 1 (HER1)]. Following this, a second agent, neutravidin-BODIPY-FL fluorescent conjugate, is given and binds to the previously targeted antibody, resulting in an similar to 10-fold amplification of the optical fluorescence signal, leading to high tumor-to-background ratios. Spectral fluorescence imaging was done in a mouse model of peritoneal metastasis using a HER1-overexpressing cell line (A431) after pretargeting with biotinylated cetuximab and 3 h after administration of neutravidin-conjugated BODIPY-FL. Both aggregated tumors as well as small cancer implants were clearly visualized in vivo. For lesions similar to 0.8 mm or greater in diameter, the spectral fluorescence imaging had a sensitivity of 96% (178 of 185) and a specificity of 98% (188 of 191). This two-step activation paradigm (pretargeting followed by neutravidin-biotin binding with an attached activatable fluorophore) could be useful in tumor-specific molecular imaging of various targets to guide surgical resections. [Cancer Res 2007; 67(8):3809-17] JF - Cancer Research AU - Hama, Yukihiro AU - Urano, Yasuteru AU - Koyama, Yoshinori AU - Choyke, Peter L AU - Kobayashi, Hisataka AD - Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland and Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 3809 EP - 3817 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 67 IS - 8 SN - 0008-5472, 0008-5472 KW - Biotechnology and Bioengineering Abstracts KW - Metastases KW - Fluorescence KW - Monoclonal antibodies KW - Peritoneum KW - Animal models KW - Epidermal growth factor receptors KW - Tumors KW - fluorophores KW - imaging KW - Cancer KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19650492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Activatable+Fluorescent+Molecular+Imaging+of+Peritoneal+Metastases+following+Pretargeting+with+a+Biotinylated+Monoclonal+Antibody&rft.au=Hama%2C+Yukihiro%3BUrano%2C+Yasuteru%3BKoyama%2C+Yoshinori%3BChoyke%2C+Peter+L%3BKobayashi%2C+Hisataka&rft.aulast=Hama&rft.aufirst=Yukihiro&rft.date=2007-04-01&rft.volume=67&rft.issue=8&rft.spage=3809&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Metastases; Fluorescence; Monoclonal antibodies; Peritoneum; Animal models; Epidermal growth factor receptors; fluorophores; Tumors; imaging; Cancer ER - TY - JOUR T1 - Self-Organization and Branching Morphogenesis of Primary Salivary Epithelial Cells AN - 19647204; 7394359 AB - Embryonic tissues may provide clues about mechanisms required for tissue reassembly and regeneration, but few studies have utilized primary embryonic tissue to study tissue assembly. To test the capacity of tissue fragments to regenerate, we cultured fragments of embryonic day 13 (E13) mouse submandibular gland (SMG) epithelium and found that fragments as small as a quarter-bud retain the ability to branch. Further, we found that completely dissociated SMG epithelial cells self-organize into structures that undergo significant branching. Investigation into the mechanisms involved in tissue self-assembly demonstrated that inhibition of beta sub(1) integrin prevents cell aggregation, while inhibition of E-cadherin hinders aggregate compaction. Immunostaining showed that the cellular architecture and expression patterns of E-cadherin, beta -catenin, and actin in the reassembled aggregates mirror those seen in intact glands. Adding SMG mesenchymal cells to the epithelial cell cultures facilitates branching and morphological differentiation. Quantitative real-time RT-PCR indicated that the aggregates express the differentiation markers aquaporin-5 (AQP5), prolactin-inducible protein (PIP), and SMG protein C (SMGC). Together, these data show that dissociated SMG epithelial cells self-organize and undergo branching morphogenesis to form tissues with structural features and differentiation markers characteristic of the intact gland. These findings provide insights into self-assembly and branching that will facilitate future regeneration strategies in the salivary gland and other organs. JF - Tissue Engineering AU - Wei, C AU - Larsen, M AU - Hoffman, M P AU - Yamada, K M AD - CDBRB, NIDCR, National Institutes of Health, Building 30, Room 426, 30 Convent Drive, MSC 4370, Bethesda, MD 20892-4370, USA, kyamada@mail.nih.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 721 EP - 735 VL - 13 IS - 4 SN - 1076-3279, 1076-3279 KW - Biotechnology and Bioengineering Abstracts KW - Epithelial cells KW - protein C KW - prolactin-inducible protein KW - Morphogenesis KW - Cell culture KW - Tissue engineering KW - Salivary gland KW - Compaction KW - E-Cadherin KW - Differentiation KW - catenin KW - Cell aggregation KW - Integrins KW - Self-assembly KW - Polymerase chain reaction KW - Submandibular gland KW - Actin KW - Embryos KW - Epithelium KW - Mesenchyme KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19647204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering&rft.atitle=Self-Organization+and+Branching+Morphogenesis+of+Primary+Salivary+Epithelial+Cells&rft.au=Wei%2C+C%3BLarsen%2C+M%3BHoffman%2C+M+P%3BYamada%2C+K+M&rft.aulast=Wei&rft.aufirst=C&rft.date=2007-04-01&rft.volume=13&rft.issue=4&rft.spage=721&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering&rft.issn=10763279&rft_id=info:doi/10.1089%2Ften.2006.0123 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Epithelial cells; prolactin-inducible protein; protein C; Morphogenesis; Cell culture; Salivary gland; Tissue engineering; Compaction; E-Cadherin; Differentiation; catenin; Integrins; Cell aggregation; Self-assembly; Polymerase chain reaction; Epithelium; Embryos; Actin; Submandibular gland; Mesenchyme DO - http://dx.doi.org/10.1089/ten.2006.0123 ER - TY - JOUR T1 - Alkaloids in Bufonid Toads (Melanophryniscus): Temporal and Geographic Determinants for Two Argentinian Species AN - 19643234; 7375789 AB - Bufonid toads of the genus Melanophryniscus represent one of several lineages of anurans with the ability to sequester alkaloids from dietary arthropods for chemical defense. The alkaloid profile for Melanophryniscus stelzneri from a location in the province of Cordoba, Argentina, changed significantly over a 10-year period, probably indicating changes in availability of alkaloid-containing arthropods. A total of 29 alkaloids were identified in two collections of this population. Eight alkaloids were identified in M. stelzneri from another location in the province of Cordoba. The alkaloid profiles of Melanophryniscus rubriventris collected from four locations in the provinces of Salta and Jujuy, Argentina, contained 44 compounds and differed considerably between locations. Furthermore, alkaloid profiles of M. stelzneri and M. rubriventris strongly differed, probably reflecting differences in the ecosystem and hence in availability of alkaloid-containing arthropods. JF - Journal of Chemical Ecology AU - Daly, J W AU - Wilham, J M AU - Spande, T F AU - Garraffo, H M AU - Gil, R R AU - Silva, G L AU - Vaira, M AD - National Institute Health, DHHS, Bethesda, MD, 20892-0820, USA, jdaly@nih.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 871 EP - 887 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 33 IS - 4 SN - 0098-0331, 0098-0331 KW - Ecology Abstracts KW - Amphibia KW - Alkaloids KW - Arthropoda KW - Anura KW - Melanophryniscus stelzneri KW - Melanophryniscus KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19643234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chemical+Ecology&rft.atitle=Alkaloids+in+Bufonid+Toads+%28Melanophryniscus%29%3A+Temporal+and+Geographic+Determinants+for+Two+Argentinian+Species&rft.au=Daly%2C+J+W%3BWilham%2C+J+M%3BSpande%2C+T+F%3BGarraffo%2C+H+M%3BGil%2C+R+R%3BSilva%2C+G+L%3BVaira%2C+M&rft.aulast=Daly&rft.aufirst=J&rft.date=2007-04-01&rft.volume=33&rft.issue=4&rft.spage=871&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chemical+Ecology&rft.issn=00980331&rft_id=info:doi/10.1007%2Fs10886-007-9261-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Alkaloids; Amphibia; Arthropoda; Anura; Melanophryniscus stelzneri; Melanophryniscus DO - http://dx.doi.org/10.1007/s10886-007-9261-x ER - TY - JOUR T1 - Essentiality of Ribosomal and Transcription Antitermination Proteins Analyzed by Systematic Gene Replacement in Escherichia coli AN - 19602641; 7316063 AB - We describe here details of the method we used to identify and distinguish essential from nonessential genes on the bacterial Escherichia coli chromosome. Three key features characterize our method: high-efficiency recombination, precise replacement of just the open reading frame of a chromosomal gene, and the presence of naturally occurring duplications within the bacterial genome. We targeted genes encoding functions critical for processes of transcription and translation. Proteins from three complexes were evaluated to determine if they were essential to the cell by deleting their individual genes. The transcription elongation Nus proteins and termination factor Rho, which are involved in rRNA antitermination, the ribosomal proteins of the small 30S ribosome subunit, and minor ribosome-associated proteins were analyzed. It was concluded that four of the five bacterial transcription antitermination proteins are essential, while all four of the minor ribosome-associated proteins examined (RMF, SRA, YfiA, and YhbH), unlike most ribosomal proteins, are dispensable. Interestingly, although most 30S ribosomal proteins were essential, the knockouts of six ribosomal protein genes, rpsF (S6), rpsI (S9), rpsM (S13), rpsO (S15), rpsQ (S17), and rpsT (S20), were viable. JF - Journal of Bacteriology AU - Bubunenko, Mikhail AU - Baker, Teresa AU - Court, Donald L AD - Basic Research Program, SAIC-Frederick, Inc., National Cancer Institute-Frederick, Frederick, Maryland 21702. Molecular Control and Genetics Section, Gene Regulation and Chromosome Biology Laboratory, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, Maryland 21702 Y1 - 2007/04/01/ PY - 2007 DA - 2007 Apr 01 SP - 2844 EP - 2853 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 189 IS - 7 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Genomes KW - Translation KW - Ribosomes KW - transcription antitermination KW - rRNA KW - Recombination KW - Chromosomes KW - Ribosomal proteins KW - Transcription elongation KW - Escherichia coli KW - Open reading frames KW - Termination factors KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19602641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Essentiality+of+Ribosomal+and+Transcription+Antitermination+Proteins+Analyzed+by+Systematic+Gene+Replacement+in+Escherichia+coli&rft.au=Bubunenko%2C+Mikhail%3BBaker%2C+Teresa%3BCourt%2C+Donald+L&rft.aulast=Bubunenko&rft.aufirst=Mikhail&rft.date=2007-04-01&rft.volume=189&rft.issue=7&rft.spage=2844&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; Recombination; Translation; rRNA; transcription antitermination; Chromosomes; Transcription elongation; Ribosomal proteins; Ribosomes; Termination factors; Open reading frames; Escherichia coli ER - TY - JOUR T1 - A Replication-Competent Adenovirus-Human Immunodeficiency Virus (Ad-HIV) tat and Ad-HIV env Priming/Tat and Envelope Protein Boosting Regimen Elicits Enhanced Protective Efficacy against Simian/Human Immunodeficiency Virus SHIV sub(89.6P) Challenge in Rhesus Macaques AN - 19602458; 7317271 AB - We previously demonstrated that replication-competent adenovirus (Ad)-simian immunodeficiency virus (SIV) recombinant prime/protein boost regimens elicit potent immunogenicity and strong, durable protection of rhesus macaques against SIV sub(mac251). Additionally, native Tat vaccines have conferred strong protection against simian/human immunodeficiency virus SHIV sub(89.6P) challenge of cynomolgus monkeys, while native, inactivated, or vectored Tat vaccines have failed to elicit similar protective efficacy in rhesus macaques. Here we asked if priming rhesus macaques with replicating Ad-human immunodeficiency virus (HIV) tat and boosting with the Tat protein would elicit protection against SHIV sub(89.6P). We also evaluated a Tat/Env regimen, adding an Ad-HIV env recombinant and envelope protein boost to test whether envelope antibodies would augment acute-phase protection. Further, expecting cellular immunity to enhance chronic viremia control, we tested a multigenic group: Ad-HIV tat, -HIV env, -SIV gag, and -SIV nef recombinants and Tat, Env, and Nef proteins. All regimens were immunogenic. A hierarchy was observed in enzyme-linked immunospot responses (with the strongest response for Env, followed by Gag, followed by Nef, followed by Tat) and antibody titers (with the highest titer for Env, followed by Tat, followed by Nef, followed by Gag). Following intravenous SHIV sub(89.6P) challenge, all macaques became infected. Compared to controls, no protection was seen in the Tat-only group, confirming previous reports for rhesus macaques. However, the multigenic group blunted acute viremia by approximately 1 log (P = 0.017), and both the multigenic and Tat/Env groups reduced chronic viremia by 3 and 4 logs, respectively, compared to controls (multigenic, P = 0.0003; Tat/Env, P < 0.0001). The strikingly greater reduction in the Tat/Env group than in the multigenic group (P = 0.014) was correlated with Tat and Env binding antibodies. Since prechallenge anti-Env antibodies lacked SHIV sub(89.6P)-neutralizing activity, other functional anti-Env and anti-Tat activities are under investigation, as is a possible synergy between the Tat and Env immunogens. JF - Journal of Virology AU - Demberg, Thorsten AU - Florese, Ruth H AU - Heath, Megan J AU - Larsen, Kay AU - Kalisz, Irene AU - Kalyanaraman, V S AU - Lee, Eun Mi AU - Pal, Ranajit AU - Venzon, David AU - Grant, Richard AU - Patterson, LJean AU - Korioth-Schmitz, Birgit AU - Buzby, Adam AU - Dombagoda, Dilani AU - Montefiori, David C AU - Letvin, Norman L AU - Cafaro, Aurelio AU - Ensoli, Barbara AU - Robert-Guroff, Marjorie AD - Vaccine Branch, National Cancer Institute, Bethesda, Maryland 20892. Washington National Primate Research Center, Seattle, Washington 98195. Advanced BioScience Laboratories, Inc., Kensington, Maryland 20895. Biostatistics and Data Management Section, National Cancer Institute, Bethesda, Maryland 20892. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115. Duke University Medical Center, Durham, North Carolina 27710. Istituto Superiore di Sanita, National AIDS Center, Rome, Italy Y1 - 2007/04/01/ PY - 2007 DA - 2007 Apr 01 SP - 3414 EP - 3427 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 81 IS - 7 SN - 0022-538X, 0022-538X KW - HIV KW - Rhesus macaque KW - Rhesus monkey KW - SIV KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Intravenous administration KW - Enzyme-linked immunosorbent assay KW - Tat protein KW - Adenovirus KW - Simian/human immunodeficiency virus KW - Nef protein KW - Gag protein KW - Antibodies KW - Immunity (cell-mediated) KW - Human immunodeficiency virus KW - Immunogenicity KW - Envelope protein KW - Cynomolgus KW - Macaca mulatta KW - Viremia KW - Vaccines KW - Simian immunodeficiency virus KW - W 30905:Medical Applications KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19602458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=A+Replication-Competent+Adenovirus-Human+Immunodeficiency+Virus+%28Ad-HIV%29+tat+and+Ad-HIV+env+Priming%2FTat+and+Envelope+Protein+Boosting+Regimen+Elicits+Enhanced+Protective+Efficacy+against+Simian%2FHuman+Immunodeficiency+Virus+SHIV+sub%2889.6P%29+Challenge+in+Rhesus+Macaques&rft.au=Demberg%2C+Thorsten%3BFlorese%2C+Ruth+H%3BHeath%2C+Megan+J%3BLarsen%2C+Kay%3BKalisz%2C+Irene%3BKalyanaraman%2C+V+S%3BLee%2C+Eun+Mi%3BPal%2C+Ranajit%3BVenzon%2C+David%3BGrant%2C+Richard%3BPatterson%2C+LJean%3BKorioth-Schmitz%2C+Birgit%3BBuzby%2C+Adam%3BDombagoda%2C+Dilani%3BMontefiori%2C+David+C%3BLetvin%2C+Norman+L%3BCafaro%2C+Aurelio%3BEnsoli%2C+Barbara%3BRobert-Guroff%2C+Marjorie&rft.aulast=Demberg&rft.aufirst=Thorsten&rft.date=2007-04-01&rft.volume=81&rft.issue=7&rft.spage=3414&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Intravenous administration; Antibodies; Immunity (cell-mediated); Immunogenicity; Tat protein; Envelope protein; Vaccines; Viremia; Nef protein; Gag protein; Human immunodeficiency virus; Simian/human immunodeficiency virus; Adenovirus; Macaca mulatta; Cynomolgus; Simian immunodeficiency virus ER - TY - JOUR T1 - The W-Beijing Lineage of Mycobacterium tuberculosis Overproduces Triglycerides and Has the DosR Dormancy Regulon Constitutively Upregulated AN - 19600033; 7316034 AB - The Beijing family of Mycobacterium tuberculosis strains has been associated with epidemic spread and an increased likelihood of developing drug resistance. The characteristics that predispose this family to such clinical outcomes have not been identified, although one potential candidate, the phenolic glycolipid PGL-tb, has been shown to mediate a fulminant lethal disease in mice and rabbits due to lipid-mediated immunosuppression. However, PGL-tb is not uniformly expressed throughout the Beijing lineage and may not be the only unique virulence trait associated with this family. In an attempt to define phenotypes common to all Beijing strains, we interrogated a carefully selected set of isolates representing the five extant lineages of the Beijing family. Comparison of lipid production in this set revealed that all Beijing strains accumulated large quantities of triacylglycerides in in vitro aerobic culture. This accumulation was found to be coincident with upregulation of Rv3130c, whose product was previously characterized as a triacylglyceride synthase. Rv3130c is a member of the DosR-controlled regulon of M. tuberculosis, and further examination revealed that several members of this regulon were upregulated throughout this strain family. The upregulation of the DosR regulon may confer an adaptive advantage for growth in microaerophilic or anaerobic environments encountered by the bacillus during infection and thus may be related to the epidemiological phenomena associated with this important strain lineage. JF - Journal of Bacteriology AU - Reed, Michael B AU - Gagneux, Sebastien AU - DeRiemer, Kathryn AU - Small, Peter M AU - Barry, Clifton EIII AD - Tuberculosis Research Section, National Institutes of Health, 12441 Parklawn Drive, Rockville, Maryland 20852. Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, California 94305. Institute for Systems Biology, 1441 North 34th Street, Seattle, Washington 98103. School of Medicine, One Shields Avenue, University of California, Davis, California 95616. Bill and Melinda Gates Foundation, Seattle, Washington 98102 Y1 - 2007/04/01/ PY - 2007 DA - 2007 Apr 01 SP - 2583 EP - 2589 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 189 IS - 7 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Epidemics KW - Lipids KW - Drug resistance KW - Infection KW - Glycolipids KW - Virulence KW - Anaerobic environments KW - Triglycerides KW - phenolic compounds KW - Tuberculosis KW - Dormancy KW - Bacillus KW - Mycobacterium tuberculosis KW - Immunosuppression KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19600033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=The+W-Beijing+Lineage+of+Mycobacterium+tuberculosis+Overproduces+Triglycerides+and+Has+the+DosR+Dormancy+Regulon+Constitutively+Upregulated&rft.au=Reed%2C+Michael+B%3BGagneux%2C+Sebastien%3BDeRiemer%2C+Kathryn%3BSmall%2C+Peter+M%3BBarry%2C+Clifton+EIII&rft.aulast=Reed&rft.aufirst=Michael&rft.date=2007-04-01&rft.volume=189&rft.issue=7&rft.spage=2583&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Virulence; Glycolipids; Anaerobic environments; Epidemics; Drug resistance; Triglycerides; Lipids; phenolic compounds; Tuberculosis; Infection; Dormancy; Immunosuppression; Bacillus; Mycobacterium tuberculosis ER - TY - JOUR T1 - Developmental exposure to endocrine disruptors and the obesity epidemic AN - 19599652; 7497198 AB - Xenobiotic and dietary compounds with hormone-like activity can disrupt endocrine signaling pathways that play important roles during perinatal differentiation and result in alterations that are not apparent until later in life. Evidence implicates developmental exposure to environmental hormone-mimics with a growing list of health problems. Obesity is currently receiving needed attention since it has potential to overwhelm health systems worldwide with associated illnesses such as diabetes and cardiovascular disease. Here, we review the literature that proposes an association of exposure to environmental endocrine disrupting chemicals with the development of obesity. We describe an animal model of developmental exposure to diethylstilbestrol (DES), a potent perinatal endocrine disruptor with estrogenic activity, to study mechanisms involved in programming an organism for obesity. This experimental animal model provides an example of the growing scientific field termed ''the developmental origins of adult disease'' and suggests new targets of abnormal programming by endocrine disrupting chemicals. JF - Reproductive Toxicology AU - Newbold, R R AU - Padilla-Banks, E AU - Snyder, R J AU - Phillips, T M AU - Jefferson, W N AD - Laboratory of Molecular Toxicology, Mail-Drop E4-02, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States, newbold1@niehs.nih.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 290 EP - 296 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 23 IS - 3 SN - 0890-6238, 0890-6238 KW - Toxicology Abstracts KW - Obesity KW - Epidemics KW - Endocrine disruptors KW - Animal models KW - estrogenic activity KW - Diabetes mellitus KW - Differentiation KW - Perinatal exposure KW - Reviews KW - Cardiovascular diseases KW - Diethylstilbestrol KW - Signal transduction KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19599652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+Toxicology&rft.atitle=Developmental+exposure+to+endocrine+disruptors+and+the+obesity+epidemic&rft.au=Newbold%2C+R+R%3BPadilla-Banks%2C+E%3BSnyder%2C+R+J%3BPhillips%2C+T+M%3BJefferson%2C+W+N&rft.aulast=Newbold&rft.aufirst=R&rft.date=2007-04-01&rft.volume=23&rft.issue=3&rft.spage=290&rft.isbn=&rft.btitle=&rft.title=Reproductive+Toxicology&rft.issn=08906238&rft_id=info:doi/10.1016%2Fj.reprotox.2006.12.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Differentiation; Obesity; Epidemics; Perinatal exposure; Reviews; Endocrine disruptors; Animal models; Cardiovascular diseases; Diethylstilbestrol; estrogenic activity; Signal transduction DO - http://dx.doi.org/10.1016/j.reprotox.2006.12.010 ER - TY - JOUR T1 - Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease AN - 19534356; 8069103 AB - Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive decline in cognitive function associated with the neuropathological hallmarks amyloid beta -peptide (A beta ) plaques and neurofibrillary tangles. Because aging is the major risk factor for AD, and dietary energy restriction can retard aging processes in the brain, we tested the hypothesis that two different energy restriction regimens, 40% calorie restriction (CR) and intermittent fasting (IF) can protect against cognitive decline in the triple-transgenic mouse model of AD (3xTgAD mice). Groups of 3xTgAD mice were maintained on an ad libitum control diet, or CR or IF diets, beginning at 3 months of age. Half of the mice in each diet group were subjected to behavioral testing (Morris swim task and open field apparatus) at 10months of age and the other half at 17 months of age. At 10 months 3xTgAD mice on the control diet exhibited reduced exploratory activity compared to non-transgenic mice and to 3xTgAD mice on CR and IF diets. Overall, there were no major differences in performance in the water maze among genotypes or diets in 10-month-old mice. In 17-month-old 3xTgAD mice the CR and IF groups exhibited higher levels of exploratory behavior, and performed better in both the goal latency and probe trials of the swim task, compared to 3xTgAD mice on the control diet. 3xTgAD mice in the CR group showed lower levels of A beta 1-40, A beta 1-42 and phospho-tau in the hippocampus compared to the control diet group, whereas A beta and phospho-tau levels were not decreased in 3xTgAD mice in the IF group. IF may therefore protect neurons against adverse effects of A beta and tau pathologies on synaptic function. We conclude that CR and IF dietary regimens can ameliorate age-related deficits in cognitive function by mechanisms that may or may not be related to A beta and tau pathologies. JF - Neurobiology of Disease AU - Halagappa, Veerendra Kumar Madala AU - Guo, Zhihong AU - Pearson, Michelle AU - Matsuoka, Yasuji AU - Cutler, Roy G AU - Laferla, Frank M AU - Mattson, Mark P AD - Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, Baltimore, MD 21224, USA, mattsonm@grc.nia.nih.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 212 EP - 220 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 26 IS - 1 SN - 0969-9961, 0969-9961 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Amyloid KW - Caloric restriction KW - Hippocampus KW - Learning and memory KW - Synaptic plasticity KW - Age KW - Exploratory behavior KW - Dietary restrictions KW - Aging KW - Alzheimer's disease KW - Animal models KW - Probes KW - Brain KW - Genotypes KW - Fasting KW - Neurodegenerative diseases KW - Nutrient deficiency KW - Antibodies KW - Cognitive ability KW - Risk factors KW - Neurons KW - Tau protein KW - Plaques KW - beta -Amyloid KW - Neurofibrillary tangles KW - Side effects KW - G 07870:Mammals KW - W 30965:Miscellaneous, Reviews KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19534356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurobiology+of+Disease&rft.atitle=Intermittent+fasting+and+caloric+restriction+ameliorate+age-related+behavioral+deficits+in+the+triple-transgenic+mouse+model+of+Alzheimer%27s+disease&rft.au=Halagappa%2C+Veerendra+Kumar+Madala%3BGuo%2C+Zhihong%3BPearson%2C+Michelle%3BMatsuoka%2C+Yasuji%3BCutler%2C+Roy+G%3BLaferla%2C+Frank+M%3BMattson%2C+Mark+P&rft.aulast=Halagappa&rft.aufirst=Veerendra+Kumar&rft.date=2007-04-01&rft.volume=26&rft.issue=1&rft.spage=212&rft.isbn=&rft.btitle=&rft.title=Neurobiology+of+Disease&rft.issn=09699961&rft_id=info:doi/10.1016%2Fj.nbd.2006.12.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Age; Exploratory behavior; Hippocampus; Dietary restrictions; Alzheimer's disease; Aging; Brain; Probes; Animal models; Fasting; Genotypes; Neurodegenerative diseases; Antibodies; Nutrient deficiency; Cognitive ability; Neurons; Risk factors; Tau protein; Plaques; Neurofibrillary tangles; beta -Amyloid; Side effects DO - http://dx.doi.org/10.1016/j.nbd.2006.12.019 ER - TY - JOUR T1 - Design and synthesis of novel heterobiaryl amides as metabotropic glutamate receptor subtype 5 antagonists AN - 19515531; 8845994 AB - A series of heterobiaryl amides was designed and synthesized as novel mGluR5 antagonists. The synthesis using palladium catalyzed Suzuki-Miyaura cross-coupling reactions provided an array of compounds with a range of in vitro activities. In particular, compound 9e, 4(3,5-difluorophenyl)-N- (6-methylpyridin-1-yl)picolinamide, exhibited nanomolar affinity at the mGluR5 and will serve as a template for future drug design. JF - Bioorganic and Medicinal Chemistry Letters AU - Kulkarni, Santosh S AU - Newman, Amy Hauck AD - Medicinal Chemistry Section, National Institute on Drug Abuse, Intramural Research Program, NIH, DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA, anewman@intra.nida.nih.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 2074 EP - 2079 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 17 IS - 7 SN - 0960-894X, 0960-894X KW - Biotechnology and Bioengineering Abstracts KW - Glutamic acid receptors (metabotropic) KW - palladium KW - Drug development KW - amides KW - Antagonists KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19515531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Design+and+synthesis+of+novel+heterobiaryl+amides+as+metabotropic+glutamate+receptor+subtype+5+antagonists&rft.au=Kulkarni%2C+Santosh+S%3BNewman%2C+Amy+Hauck&rft.aulast=Kulkarni&rft.aufirst=Santosh&rft.date=2007-04-01&rft.volume=17&rft.issue=7&rft.spage=2074&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2006.12.083 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - palladium; Glutamic acid receptors (metabotropic); Drug development; amides; Antagonists DO - http://dx.doi.org/10.1016/j.bmcl.2006.12.083 ER - TY - JOUR T1 - Bell's palsy associated with influenza vaccination: Two case reports AN - 19454697; 7640564 AB - The etiology of Bell's palsy is often unknown. We present herein two cases of adults who developed a Bell's palsy following the administration of an influenza vaccine. While the incidence is low, with the widespread recommendation for annual influenza vaccines, patients should be apprised of the possibility of this complication and the benefit of early treatment. JF - Vaccine AU - Chou, Cheng-Hsiu AU - Liou, Wen-Ping AU - Hu, Kun-I AU - Loh, Ching-Hui AU - Chou, Chih-Chieh AU - Chen, Yeong-Hwang AD - Department of Family Medicine, Tri-Service General Hospital, Nei-Hu, Taipei, Taiwan, ROC, annyuu719@yahoo.com.tw Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 2839 EP - 2841 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 25 IS - 15 SN - 0264-410X, 0264-410X KW - Bell's palsy KW - Toxicology Abstracts; Virology & AIDS Abstracts; Immunology Abstracts; Health & Safety Science Abstracts KW - Influenza vaccination KW - Adverse effects KW - Influenza KW - vaccines KW - Etiology KW - Case reports KW - Vaccines KW - Side effects KW - influenza KW - X 24310:Pharmaceuticals KW - V 22350:Immunology KW - F 06905:Vaccines KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19454697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Bell%27s+palsy+associated+with+influenza+vaccination%3A+Two+case+reports&rft.au=Chou%2C+Cheng-Hsiu%3BLiou%2C+Wen-Ping%3BHu%2C+Kun-I%3BLoh%2C+Ching-Hui%3BChou%2C+Chih-Chieh%3BChen%2C+Yeong-Hwang&rft.aulast=Chou&rft.aufirst=Cheng-Hsiu&rft.date=2007-04-01&rft.volume=25&rft.issue=15&rft.spage=2839&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2006.10.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Influenza; Etiology; Case reports; Vaccines; Bell's palsy; vaccines; Side effects; influenza DO - http://dx.doi.org/10.1016/j.vaccine.2006.10.006 ER - TY - JOUR T1 - Pleural and pericardial effusion: a potential ultrasonographic marker for the prenatal differential diagnosis between congenital diaphragmatic eventration and congenital diaphragmatic hernia AN - 19277775; 8634318 AB - Objectives To determine whether or not the presence of pleural and/or pericardial effusion can be used prenatally as an ultrasonographic marker for the differential diagnosis between diaphragmatic eventration and diaphragmatic hernia. Methods We present two case reports of non-isolated diaphragmatic eventration associated with pleural and/or pericardial effusion. Additionally, we reviewed the literature for all cases of congenital diaphragmatic hernia (CDH) and diaphragmatic eventration that met the following criteria: (1) prenatal diagnosis of a diaphragmatic defect and (2) definitive diagnosis by autopsy or surgery. The frequencies of pleural effusion, pericardial effusion and hydrops were compared between the two conditions using Fisher's exact test. A subanalysis was conducted of cases with isolated diaphragmatic defects (i.e. diaphragmatic defects not associated with hydrops and other major structural or chromosomal anomalies). Results A higher proportion of fetuses with diaphragmatic eventration had associated pleural and pericardial effusions compared with fetuses with diaphragmatic hernia (58% (7/12) vs. 3.7% (14/382), respectively, P < 0.001). This observation remained true when only cases of diaphragmatic defects not associated with hydrops and other major structural or chromosomal anomalies were compared (29% (2/7) with eventration vs. 2.2% (4/178) with CDH, P < 0.02). Conclusions The presence of pleural and/or pericardial effusion in patients with diaphragmatic defects should raise the possibility of a congenital diaphragmatic eventration. This information is clinically important for management and counseling because the prognosis and treatment for CDH and congenital diaphragmatic eventration are different. JF - Ultrasound in Obstetrics and Gynecology AU - Jeanty, C AU - Nien, J K AU - Espinoza, J AU - Kusanovic, J P AU - Goncalves, L F AU - Qureshi, F AU - Jacques, S AU - Lee, W AU - Romero, R AD - Perinatology Research Branch, National Institute of Child Health and Human Development, NIH/DHHS, Bethesda, MD and Detroit, MI, USA, warfiela@mail.nih.gov Y1 - 2007/04// PY - 2007 DA - Apr 2007 SP - 378 EP - 387 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 29 IS - 4 SN - 0960-7692, 0960-7692 KW - Biotechnology and Bioengineering Abstracts KW - Autopsy KW - Gynecology KW - Prognosis KW - Edema KW - Effusion KW - Pleural effusion KW - Prenatal diagnosis KW - Fetuses KW - Differential diagnosis KW - Case reports KW - Surgery KW - Hernia KW - Obstetrics KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19277775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=Pleural+and+pericardial+effusion%3A+a+potential+ultrasonographic+marker+for+the+prenatal+differential+diagnosis+between+congenital+diaphragmatic+eventration+and+congenital+diaphragmatic+hernia&rft.au=Jeanty%2C+C%3BNien%2C+J+K%3BEspinoza%2C+J%3BKusanovic%2C+J+P%3BGoncalves%2C+L+F%3BQureshi%2C+F%3BJacques%2C+S%3BLee%2C+W%3BRomero%2C+R&rft.aulast=Jeanty&rft.aufirst=C&rft.date=2007-04-01&rft.volume=29&rft.issue=4&rft.spage=378&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=09607692&rft_id=info:doi/10.1002%2Fuog.3958 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Effusion; Hernia; Edema; Fetuses; Differential diagnosis; Surgery; Pleural effusion; Ultrasound; Autopsy; Gynecology; Prenatal diagnosis; Obstetrics; Case reports; Prognosis DO - http://dx.doi.org/10.1002/uog.3958 ER - TY - JOUR T1 - Selection of anthrax toxin protective antigen variants that discriminate between the cellular receptors TEM8 and CMG2 and achieve targeting of tumor cells. AN - 70313374; 17251181 AB - Anthrax toxin, a three-component protein toxin secreted by Bacillus anthracis, assembles into toxic complexes at the surface of receptor-bearing eukaryotic cells. The protective antigen (PA) protein binds to receptors, either tumor endothelial cell marker 8 (TEM8) or CMG2 (capillary morphogenesis protein 2), and orchestrates the delivery of the lethal and edema factors into the cytosol. TEM8 is reported to be overexpressed during tumor angiogenesis, whereas CMG2 is more widely expressed in normal tissues. To extend prior work on targeting of tumor with modified anthrax toxins, we used phage display to select PA variants that preferentially bind to TEM8 as compared with CMG2. Substitutions were randomly introduced into residues 605-729 of PA, within the C-terminal domain 4 of PA, which is the principal region that contacts receptor. Candidates were characterized in cellular cytotoxicity assays with Chinese hamster ovary (CHO) cells expressing either TEM8 or CMG2. A PA mutant having the substitutions R659S and M662R had enhanced specificity toward TEM8-overexpressing CHO cells. This PA variant also displayed broad and potent tumoricidal activity to various human tumor cells, especially to HeLa and A549/ATCC cells. By contrast, the substitution N657Q significantly reduced toxicity to TEM8 but not CMG2-overexpressing CHO cells. Our results indicate that certain amino acid substitutions within PA domain 4 create anthrax toxins that selectively kill human tumor cells. The PA R659S/M662R protein may be useful as a therapeutic agent for cancer treatment. JF - The Journal of biological chemistry AU - Chen, Kuang-Hua AU - Liu, Shihui AU - Bankston, Laurie A AU - Liddington, Robert C AU - Leppla, Stephen H AD - Laboratory of Bacterial Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892-3202, USA. Y1 - 2007/03/30/ PY - 2007 DA - 2007 Mar 30 SP - 9834 EP - 9845 VL - 282 IS - 13 SN - 0021-9258, 0021-9258 KW - ANTXR1 protein, human KW - 0 KW - ANTXR2 protein, human KW - Antigens, Bacterial KW - Bacterial Toxins KW - Membrane Proteins KW - Neoplasm Proteins KW - Receptors, Cell Surface KW - Receptors, Peptide KW - anthrax toxin KW - Index Medicus KW - Animals KW - Protein Structure, Tertiary -- genetics KW - Cricetulus KW - HeLa Cells KW - Amino Acid Substitution -- genetics KW - Humans KW - Molecular Sequence Data KW - CHO Cells KW - Cell Line, Tumor KW - Amino Acid Sequence KW - Cell Line KW - Cricetinae KW - Receptors, Cell Surface -- metabolism KW - Bacterial Toxins -- genetics KW - Antigenic Variation KW - Bacterial Toxins -- metabolism KW - Antigens, Bacterial -- metabolism KW - Membrane Proteins -- metabolism KW - Bacterial Toxins -- chemistry KW - Neoplasm Proteins -- metabolism KW - Antigens, Bacterial -- genetics KW - Antigens, Bacterial -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70313374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Selection+of+anthrax+toxin+protective+antigen+variants+that+discriminate+between+the+cellular+receptors+TEM8+and+CMG2+and+achieve+targeting+of+tumor+cells.&rft.au=Chen%2C+Kuang-Hua%3BLiu%2C+Shihui%3BBankston%2C+Laurie+A%3BLiddington%2C+Robert+C%3BLeppla%2C+Stephen+H&rft.aulast=Chen&rft.aufirst=Kuang-Hua&rft.date=2007-03-30&rft.volume=282&rft.issue=13&rft.spage=9834&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-10 N1 - Date created - 2007-03-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Infect Immun. 1999 Feb;67(2):964-7 [9916116] J Biol Chem. 1997 Nov 7;272(45):28512-7 [9353312] Trends Microbiol. 2005 Feb;13(2):72-8 [15680766] Nat Biotechnol. 2005 Jun;23(6):725-30 [15895075] J Infect Dis. 2005 Sep 15;192(6):1047-51 [16107958] PLoS Pathog. 2006 Oct;2(10):e111 [17054395] Science. 2000 Aug 18;289(5482):1197-202 [10947988] Cancer Res. 2000 Nov 1;60(21):6061-7 [11085528] J Biol Chem. 2001 May 25;276(21):17976-84 [11278833] Cancer Res. 2001 Sep 15;61(18):6649-55 [11559528] Nature. 2001 Nov 8;414(6860):225-9 [11700562] Nature. 2001 Nov 8;414(6860):229-33 [11700563] Nature. 2002 Jan 24;415(6870):396-402 [11807546] J Ind Microbiol Biotechnol. 2002 Apr;28(4):232-8 [11986925] Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):657-62 [12525700] J Biol Chem. 2003 Feb 14;278(7):5227-34 [12468536] Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5170-4 [12700348] Expert Opin Biol Ther. 2003 Aug;3(5):843-53 [12880383] J Biol Chem. 2003 Aug 15;278(33):30936-44 [12771151] Cancer Res. 2004 Feb 1;64(3):817-20 [14871805] Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6367-72 [15079089] Nature. 2004 Aug 19;430(7002):905-8 [15243628] Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13147-51 [15326297] J Biol Chem. 1989 Nov 15;264(32):19103-7 [2509473] J Biol Chem. 1991 Apr 15;266(11):6747-55 [1849891] Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10277-81 [1438214] J Biol Chem. 1993 Feb 15;268(5):3334-41 [8429009] J Mol Biol. 1996 Feb 2;255(4):589-603 [8568899] Nature. 1997 Feb 27;385(6619):833-8 [9039918] J Biol Chem. 1997 Aug 15;272(33):20456-62 [9252355] Infect Immun. 1999 Apr;67(4):1860-5 [10085028] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - beta-Catenin/TCF/LEF regulate expression of the short form human Cripto-1. AN - 69036781; 17291450 AB - The human gene Teratocarcinoma-derived growth factor 1 (TDGF1)/Cripto-1/CR-1 which is expressed in a wide variety of human carcinomas is a member of the EGF-cripto FRL1 cryptic (EGF-CFC) gene family. A majority of human colorectal tumors and hepatomas are known to possess a constitutively active canonical Wnt/beta-catenin/TCF signaling pathway, also express CR-1. Expression of a short form of CR-1 mRNA in colon carcinoma and hepatoma cell lines suggests that there may be differential regulation of CR-1 expression by the canonical Wnt signaling pathway in colon cancer as well as hepatoma cell lines. The present study demonstrates a direct transcriptional regulation of the short form CR-1 expression by the canonical Wnt signaling pathway through an intronic-exonic enhancer element, containing three tandem TCF/LEF binding sites within the CR-1 gene. JF - Biochemical and biophysical research communications AU - Hamada, Shin AU - Watanabe, Kazuhide AU - Hirota, Morihisa AU - Bianco, Caterina AU - Strizzi, Luigi AU - Mancino, Mario AU - Gonzales, Monica AU - Salomon, David S AD - Mammary Biology and Tumorigenesis Laboratory, NCI/CCR, 37 Convent Drive, Building 37, Bethesda, MD 20892, USA. Y1 - 2007/03/30/ PY - 2007 DA - 2007 Mar 30 SP - 240 EP - 244 VL - 355 IS - 1 SN - 0006-291X, 0006-291X KW - GPI-Linked Proteins KW - 0 KW - Intercellular Signaling Peptides and Proteins KW - Lymphoid Enhancer-Binding Factor 1 KW - Membrane Glycoproteins KW - Neoplasm Proteins KW - Protein Isoforms KW - RNA, Messenger KW - Recombinant Proteins KW - TCF Transcription Factors KW - TDGF1 protein, human KW - beta Catenin KW - Epidermal Growth Factor KW - 62229-50-9 KW - Index Medicus KW - Carcinoma, Hepatocellular KW - Humans KW - Transcription, Genetic KW - Cell Line, Tumor KW - RNA, Messenger -- genetics KW - Binding Sites KW - Carcinoma KW - Liver Neoplasms KW - Recombinant Proteins -- metabolism KW - Enhancer Elements, Genetic KW - Genetic Vectors KW - Protein Isoforms -- genetics KW - Colonic Neoplasms KW - Lymphoid Enhancer-Binding Factor 1 -- metabolism KW - Gene Expression Regulation, Neoplastic KW - beta Catenin -- metabolism KW - Neoplasm Proteins -- genetics KW - Lymphoid Enhancer-Binding Factor 1 -- genetics KW - Epidermal Growth Factor -- genetics KW - TCF Transcription Factors -- metabolism KW - TCF Transcription Factors -- genetics KW - Membrane Glycoproteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69036781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=beta-Catenin%2FTCF%2FLEF+regulate+expression+of+the+short+form+human+Cripto-1.&rft.au=Hamada%2C+Shin%3BWatanabe%2C+Kazuhide%3BHirota%2C+Morihisa%3BBianco%2C+Caterina%3BStrizzi%2C+Luigi%3BMancino%2C+Mario%3BGonzales%2C+Monica%3BSalomon%2C+David+S&rft.aulast=Hamada&rft.aufirst=Shin&rft.date=2007-03-30&rft.volume=355&rft.issue=1&rft.spage=240&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-10 N1 - Date created - 2007-02-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genes Dev. 2001 Aug 1;15(15):2010-22 [11485994] J Biol Chem. 2006 Nov 3;281(44):33497-504 [16954206] Mol Cell Biol. 2002 Apr;22(8):2586-97 [11909953] Mol Cell Biol. 2003 Mar;23(5):1674-87 [12588987] Cancer Res. 2003 Mar 15;63(6):1192-7 [12649175] Biochim Biophys Acta. 2003 Jun 5;1653(1):1-24 [12781368] Development. 2003 Dec;130(25):6283-94 [14623818] J Cell Physiol. 2004 Nov;201(2):266-76 [15334661] Oncogene. 1997 Aug 18;15(8):927-36 [9285688] Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8847-51 [9671767] Nature. 1999 Jun 24;399(6738):798-802 [10391247] Curr Top Dev Biol. 2005;67:85-133 [15949532] Oncogene. 2005 Jun 9;24(25):4094-105 [15897912] Am J Pathol. 2005 Aug;167(2):585-97 [16049342] Clin Cancer Res. 2006 Sep 1;12(17):5158-64 [16951234] Cancer Res. 2006 Sep 15;66(18):9245-51 [16982769] Tumour Biol. 2001 Sep-Oct;22(5):286-93 [11553858] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Using Socially Relevant Unconditioned Stimuli to Examine the Associative Learning Components of Social Anxiety Disorder T2 - 27th Annual Conference of the Anxiety Disorders Association of America AN - 40597896; 4552341 JF - 27th Annual Conference of the Anxiety Disorders Association of America AU - Lissek, Shmuel AU - Biggs, Arter B AU - Pine, Daniel S AU - Grillon, Christian Y1 - 2007/03/29/ PY - 2007 DA - 2007 Mar 29 KW - Anxiety KW - Associative learning KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40597896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America&rft.atitle=Using+Socially+Relevant+Unconditioned+Stimuli+to+Examine+the+Associative+Learning+Components+of+Social+Anxiety+Disorder&rft.au=Lissek%2C+Shmuel%3BBiggs%2C+Arter+B%3BPine%2C+Daniel+S%3BGrillon%2C+Christian&rft.aulast=Lissek&rft.aufirst=Shmuel&rft.date=2007-03-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Conference+of+the+Anxiety+Disorders+Association+of+America&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BAED38011%2D6166%2D4736% 2DBCD7%2D2602BD295B49%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetically Engineering Human T Cell Receptor Structure T2 - 2007 Keystone Symposia on Potent New Anti-Tumor Immunotherapies (D1) AN - 40546774; 4530819 JF - 2007 Keystone Symposia on Potent New Anti-Tumor Immunotherapies (D1) AU - Cohen, Cyrille J Y1 - 2007/03/28/ PY - 2007 DA - 2007 Mar 28 KW - T-cell receptor KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40546774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Potent+New+Anti-Tumor+Immunotherapies+%28D1%29&rft.atitle=Genetically+Engineering+Human+T+Cell+Receptor+Structure&rft.au=Cohen%2C+Cyrille+J&rft.aulast=Cohen&rft.aufirst=Cyrille&rft.date=2007-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Potent+New+Anti-Tumor+Immunotherapies+%28D1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Engineering of T Cells for the Recognition of Renal Cell Tumors T2 - 2007 Keystone Symposia on Potent New Anti-Tumor Immunotherapies (D1) AN - 40546015; 4530812 JF - 2007 Keystone Symposia on Potent New Anti-Tumor Immunotherapies (D1) AU - Hanada, Ken-ichi Y1 - 2007/03/28/ PY - 2007 DA - 2007 Mar 28 KW - Genetic engineering KW - Tumors KW - Lymphocytes T KW - Kidneys KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40546015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Potent+New+Anti-Tumor+Immunotherapies+%28D1%29&rft.atitle=Genetic+Engineering+of+T+Cells+for+the+Recognition+of+Renal+Cell+Tumors&rft.au=Hanada%2C+Ken-ichi&rft.aulast=Hanada&rft.aufirst=Ken-ichi&rft.date=2007-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Potent+New+Anti-Tumor+Immunotherapies+%28D1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - INVITED ARTICLE: HIV Treatment Adherence Research and Intervention: Current Advances and Future Challenges AN - 61397826; 200705027 AB - Maximizing treatment adherence is essential for optimizing clinical outcomes among HIV/AIDS patients. A decade after the introduction of combination antiretroviral therapy (ART), numerous achievements and continued challenges are evident within research on HIV treatment adherence. In this paper, we illustrate some key themes within current treatment adherence research by highlighting presentations from a recent conference focused on this topic (the 2006 NIMH/IAPAC International Conference on HIV Treatment Adherence). We then discuss several ongoing challenges confronting the field, and suggest that multidisciplinary research will be essential for overcoming these challenges and strengthening our efforts to improve and sustain adherence to HIV treatment. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Journal of HIV/AIDS & Social Services AU - Stirratt, Michael J AU - Gordon, Christopher M AD - Program Officer, Adherence Program, DAHBR, National Institute of Mental Health, Bethesda, MD, 20892 email: stirrattm@mail.nih.gov Y1 - 2007/03/27/ PY - 2007 DA - 2007 Mar 27 SP - 9 EP - 22 PB - Haworth Press, Binghamton NY VL - 6 IS - 1-2 SN - 1538-1501, 1538-1501 KW - Treatment Compliance KW - Acquired Immune Deficiency Syndrome KW - Medications KW - Intervention KW - Interdisciplinary Approach KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61397826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+HIV%2FAIDS+%26+Social+Services&rft.atitle=INVITED+ARTICLE%3A+HIV+Treatment+Adherence+Research+and+Intervention%3A+Current+Advances+and+Future+Challenges&rft.au=Stirratt%2C+Michael+J%3BGordon%2C+Christopher+M&rft.aulast=Stirratt&rft.aufirst=Michael&rft.date=2007-03-27&rft.volume=6&rft.issue=1-2&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Journal+of+HIV%2FAIDS+%26+Social+Services&rft.issn=15381501&rft_id=info:doi/10.1300%2FJ187v06n01_02 LA - English DB - Social Services Abstracts N1 - Date revised - 2007-12-10 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Acquired Immune Deficiency Syndrome; Medications; Intervention; Treatment Compliance; Interdisciplinary Approach DO - http://dx.doi.org/10.1300/J187v06n01_02 ER - TY - CPAPER T1 - PPARalpha Control of Hepatic Gene Expression and Carcinogenesis T2 - 2007 Keystone Symposia on Nuclear Receptor Pathways to Metabolic Regulation (Z1) AN - 40554548; 4528381 JF - 2007 Keystone Symposia on Nuclear Receptor Pathways to Metabolic Regulation (Z1) AU - Gonzalez, Frank J Y1 - 2007/03/27/ PY - 2007 DA - 2007 Mar 27 KW - Carcinogenesis KW - Gene expression KW - Liver KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40554548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Nuclear+Receptor+Pathways+to+Metabolic+Regulation+%28Z1%29&rft.atitle=PPARalpha+Control+of+Hepatic+Gene+Expression+and+Carcinogenesis&rft.au=Gonzalez%2C+Frank+J&rft.aulast=Gonzalez&rft.aufirst=Frank&rft.date=2007-03-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Nuclear+Receptor+Pathways+to+Metabolic+Regulation+%28Z1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=83 6&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interactions among the Polymer Components of Cartilage Matrix T2 - 233rd National Meeting and Exposition of the American Chemical Society AN - 40590345; 4543897 JF - 233rd National Meeting and Exposition of the American Chemical Society AU - Horkay, Ferenc AU - Lin, David C AU - Dimitriadis, Emilios K AU - Horkayne-Szakaly, Iren AU - Basser, Peter J Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Polymers KW - Cartilage KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40590345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Interactions+among+the+Polymer+Components+of+Cartilage+Matrix&rft.au=Horkay%2C+Ferenc%3BLin%2C+David+C%3BDimitriadis%2C+Emilios+K%3BHorkayne-Szakaly%2C+Iren%3BBasser%2C+Peter+J&rft.aulast=Horkay&rft.aufirst=Ferenc&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/233nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synthesis of Bifunctional Small Molecules for Imaging b-Amyloid Aggregation T2 - 233rd National Meeting and Exposition of the American Chemical Society AN - 40588296; 4543811 JF - 233rd National Meeting and Exposition of the American Chemical Society AU - Negussie, Ayele H AU - Akinola, Adeniyi O AU - Fung, Selena AU - Li, King C AU - Danthi, Narasimhan S Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Imaging techniques KW - Alzheimer's disease KW - B-Amyloid KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40588296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Synthesis+of+Bifunctional+Small+Molecules+for+Imaging+b-Amyloid+Aggregation&rft.au=Negussie%2C+Ayele+H%3BAkinola%2C+Adeniyi+O%3BFung%2C+Selena%3BLi%2C+King+C%3BDanthi%2C+Narasimhan+S&rft.aulast=Negussie&rft.aufirst=Ayele&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/233nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Long-Term Evaluation of Nodular and Ring Enhancing Lesion Evolution in Patients with Multiple Sclerosis T2 - 233rd National Meeting and Exposition of the American Chemical Society AN - 40586645; 4543939 JF - 233rd National Meeting and Exposition of the American Chemical Society AU - Davis, Marshall L Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Lesions KW - Multiple sclerosis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40586645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Long-Term+Evaluation+of+Nodular+and+Ring+Enhancing+Lesion+Evolution+in+Patients+with+Multiple+Sclerosis&rft.au=Davis%2C+Marshall+L&rft.aulast=Davis&rft.aufirst=Marshall&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/233nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prodrugs of PROLI/NO, a Nitric Oxide Donor T2 - 233rd National Meeting and Exposition of the American Chemical Society AN - 40586545; 4543901 JF - 233rd National Meeting and Exposition of the American Chemical Society AU - Chakrapani, Harinath AU - Saavedra, Joseph E AU - Showalter, Brett M AU - Keefer, Larry K Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Nitric oxide KW - Prodrugs KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40586545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Prodrugs+of+PROLI%2FNO%2C+a+Nitric+Oxide+Donor&rft.au=Chakrapani%2C+Harinath%3BSaavedra%2C+Joseph+E%3BShowalter%2C+Brett+M%3BKeefer%2C+Larry+K&rft.aulast=Chakrapani&rft.aufirst=Harinath&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/233nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modeling Study of the Binding Modes of Mono- And Dinucleotides at the Human P2Y@@d2@ Receptor T2 - 233rd National Meeting and Exposition of the American Chemical Society AN - 40586310; 4543768 JF - 233rd National Meeting and Exposition of the American Chemical Society AU - Ivanov, Andrei A AU - Jacobson, Kenneth A Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Purine P2Y receptors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40586310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Modeling+Study+of+the+Binding+Modes+of+Mono-+And+Dinucleotides+at+the+Human+P2Y%40%40d2%40+Receptor&rft.au=Ivanov%2C+Andrei+A%3BJacobson%2C+Kenneth+A&rft.aulast=Ivanov&rft.aufirst=Andrei&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/233nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - From Beta-Peptides to Peptide Nucleic Acids: Development of Non-Natural Oligomers T2 - 233rd National Meeting and Exposition of the American Chemical Society AN - 40585720; 4546124 JF - 233rd National Meeting and Exposition of the American Chemical Society AU - Appella, Daniel H Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Nucleic acids KW - Peptide nucleic acids KW - Peptides KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40585720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=From+Beta-Peptides+to+Peptide+Nucleic+Acids%3A+Development+of+Non-Natural+Oligomers&rft.au=Appella%2C+Daniel+H&rft.aulast=Appella&rft.aufirst=Daniel&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/233nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stability and Structure of Oligomers of the Alzheimer Peptide from Computer Simulations T2 - 233rd National Meeting and Exposition of the American Chemical Society AN - 40583282; 4541913 JF - 233rd National Meeting and Exposition of the American Chemical Society AU - Zheng, Jie AU - Ma, Buyong AU - Jang, Hyunbum AU - Nussinov, Ruth Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Simulation KW - Mathematical models KW - Neurodegenerative diseases KW - Alzheimer's disease KW - Peptides KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40583282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Stability+and+Structure+of+Oligomers+of+the+Alzheimer+Peptide+from+Computer+Simulations&rft.au=Zheng%2C+Jie%3BMa%2C+Buyong%3BJang%2C+Hyunbum%3BNussinov%2C+Ruth&rft.aulast=Zheng&rft.aufirst=Jie&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/233nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Encapsulation of Dextran Coated Superparamagnetic Particles and Drugs in Liposomes for Controlled Release T2 - 233rd National Meeting and Exposition of the American Chemical Society AN - 40583170; 4541507 JF - 233rd National Meeting and Exposition of the American Chemical Society AU - Lee, Jae-Ho AU - Frank, Joseph A Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Particulates KW - Drugs KW - Liposomes KW - Encapsulation KW - Dextran KW - Controlled release KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40583170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Encapsulation+of+Dextran+Coated+Superparamagnetic+Particles+and+Drugs+in+Liposomes+for+Controlled+Release&rft.au=Lee%2C+Jae-Ho%3BFrank%2C+Joseph+A&rft.aulast=Lee&rft.aufirst=Jae-Ho&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/233nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Recent Methods for Examining Macromolecular Systems T2 - 233rd National Meeting and Exposition of the American Chemical Society AN - 40582952; 4541927 JF - 233rd National Meeting and Exposition of the American Chemical Society AU - Brooks, Bernard R AU - Klauda, Jeffery B AU - Woodcock III, H Lee AU - Wu, Xiongwu Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Macromolecules KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40582952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Evaluation+of+Recent+Methods+for+Examining+Macromolecular+Systems&rft.au=Brooks%2C+Bernard+R%3BKlauda%2C+Jeffery+B%3BWoodcock+III%2C+H+Lee%3BWu%2C+Xiongwu&rft.aulast=Brooks&rft.aufirst=Bernard&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/233nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modifying the Bicyclo[3.1.0]Hexane Pseudosugar Ring of Carbocyclic Nucleosides to Improve Recognition by Herpes Thymidine Kinase T2 - 233rd National Meeting and Exposition of the American Chemical Society AN - 40582194; 4546588 JF - 233rd National Meeting and Exposition of the American Chemical Society AU - Comin, Maria J AU - Marquez, Victor E Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Thymidine kinase KW - Nucleosides KW - Herpes simplex KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40582194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Modifying+the+Bicyclo%5B3.1.0%5DHexane+Pseudosugar+Ring+of+Carbocyclic+Nucleosides+to+Improve+Recognition+by+Herpes+Thymidine+Kinase&rft.au=Comin%2C+Maria+J%3BMarquez%2C+Victor+E&rft.aulast=Comin&rft.aufirst=Maria&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/233nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Probing Ligand Dynamics in Heme Proteins with Time-Resolved Vibrational Spectroscopy, Time-Resolved X-ray Crystallography, and MD Simulations T2 - 233rd National Meeting and Exposition of the American Chemical Society AN - 40577268; 4544302 JF - 233rd National Meeting and Exposition of the American Chemical Society AU - Anfinrud, Philip A AU - Schotte, Friedrich AU - Hummer, Gerhard Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Spectroscopy KW - Simulation KW - X-ray crystallography KW - Heme proteins KW - Ligands KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40577268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Probing+Ligand+Dynamics+in+Heme+Proteins+with+Time-Resolved+Vibrational+Spectroscopy%2C+Time-Resolved+X-ray+Crystallography%2C+and+MD+Simulations&rft.au=Anfinrud%2C+Philip+A%3BSchotte%2C+Friedrich%3BHummer%2C+Gerhard&rft.aulast=Anfinrud&rft.aufirst=Philip&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/233nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Ions on the Thermodynamic Properties of Biopolymer Gels T2 - 233rd National Meeting and Exposition of the American Chemical Society AN - 40576554; 4544629 JF - 233rd National Meeting and Exposition of the American Chemical Society AU - Horkay, Ferenc AU - Basser, Peter J Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Ions KW - Biopolymers KW - Thermodynamics KW - Gels KW - Thermodynamic properties KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40576554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Effect+of+Ions+on+the+Thermodynamic+Properties+of+Biopolymer+Gels&rft.au=Horkay%2C+Ferenc%3BBasser%2C+Peter+J&rft.aulast=Horkay&rft.aufirst=Ferenc&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/233nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamics of Protein Folding T2 - 233rd National Meeting and Exposition of the American Chemical Society AN - 40574929; 4544310 JF - 233rd National Meeting and Exposition of the American Chemical Society AU - Eaton, William A Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Protein folding KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40574929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Dynamics+of+Protein+Folding&rft.au=Eaton%2C+William+A&rft.aulast=Eaton&rft.aufirst=William&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/233nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Binding Specificity of HIV-Fusion Blocking Protein (MVL) Determined by NMR Techniques T2 - 233rd National Meeting and Exposition of the American Chemical Society AN - 40574006; 4542539 JF - 233rd National Meeting and Exposition of the American Chemical Society AU - Hussan, Syed Shahzad ul AU - Bewley, Carole A Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - N.M.R. KW - Specificity KW - Human immunodeficiency virus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40574006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Binding+Specificity+of+HIV-Fusion+Blocking+Protein+%28MVL%29+Determined+by+NMR+Techniques&rft.au=Hussan%2C+Syed+Shahzad+ul%3BBewley%2C+Carole+A&rft.aulast=Hussan&rft.aufirst=Syed+Shahzad&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/233nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synthesis and Potency of PA-824 and Metronidazole Analogs as Probes for Anaerobic vs. Aerobic Activity Against Mycobacterium Tuberculosis T2 - 233rd National Meeting and Exposition of the American Chemical Society AN - 40573743; 4542516 JF - 233rd National Meeting and Exposition of the American Chemical Society AU - Kim, Pilho AU - Manjunatha, Ujjini AU - Barry III, Clifton E AU - Dowd, Cynthia S Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Tuberculosis KW - Probes KW - Metronidazole KW - Analogs KW - Mycobacterium tuberculosis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40573743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Synthesis+and+Potency+of+PA-824+and+Metronidazole+Analogs+as+Probes+for+Anaerobic+vs.+Aerobic+Activity+Against+Mycobacterium+Tuberculosis&rft.au=Kim%2C+Pilho%3BManjunatha%2C+Ujjini%3BBarry+III%2C+Clifton+E%3BDowd%2C+Cynthia+S&rft.aulast=Kim&rft.aufirst=Pilho&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/233nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Correspondence of Simulation and Experiment for Lipid Bilayers T2 - 233rd National Meeting and Exposition of the American Chemical Society AN - 40573425; 4541962 JF - 233rd National Meeting and Exposition of the American Chemical Society AU - Pastor, Richard W Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Lipid bilayers KW - Simulation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40573425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Correspondence+of+Simulation+and+Experiment+for+Lipid+Bilayers&rft.au=Pastor%2C+Richard+W&rft.aulast=Pastor&rft.aufirst=Richard&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/233nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Small Molecule Inhibitors of Mycothiol Production from Mycobacterium Tuberculosis T2 - 233rd National Meeting and Exposition of the American Chemical Society AN - 40572619; 4542517 JF - 233rd National Meeting and Exposition of the American Chemical Society AU - Metaferia, Belhu B AU - Hussan, Syed Shahzad ul AU - Bewley, Carole A Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Tuberculosis KW - Mycothiol KW - Inhibitors KW - Mycobacterium tuberculosis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40572619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Small+Molecule+Inhibitors+of+Mycothiol+Production+from+Mycobacterium+Tuberculosis&rft.au=Metaferia%2C+Belhu+B%3BHussan%2C+Syed+Shahzad+ul%3BBewley%2C+Carole+A&rft.aulast=Metaferia&rft.aufirst=Belhu&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/233nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Protein Dynamics and Solvation from Molecular Simulations: Comparison to Time-Resolved and High-Pressure X-Ray Crystallography T2 - 233rd National Meeting and Exposition of the American Chemical Society AN - 40572440; 4541950 JF - 233rd National Meeting and Exposition of the American Chemical Society AU - Hummer, Gerhard Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Simulation KW - X-ray crystallography KW - Solvation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40572440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Protein+Dynamics+and+Solvation+from+Molecular+Simulations%3A+Comparison+to+Time-Resolved+and+High-Pressure+X-Ray+Crystallography&rft.au=Hummer%2C+Gerhard&rft.aulast=Hummer&rft.aufirst=Gerhard&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/233nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Optimizing the Synthesis of N-Methanocarbathymidine, a Potent and Selective Antiviral Agent T2 - 233rd National Meeting and Exposition of the American Chemical Society AN - 40572259; 4542531 JF - 233rd National Meeting and Exposition of the American Chemical Society AU - Marquez, Victor E AU - Ludek, Olaf R Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Antiviral agents KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40572259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Optimizing+the+Synthesis+of+N-Methanocarbathymidine%2C+a+Potent+and+Selective+Antiviral+Agent&rft.au=Marquez%2C+Victor+E%3BLudek%2C+Olaf+R&rft.aulast=Marquez&rft.aufirst=Victor&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/233nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular and Toxicological Responses to Mercurials in C. elegans T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40572154; 4536622 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - McElwee, M K AU - Boyd, W A AU - Freedman, J H Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Mercury KW - Metallothionein KW - Cadmium KW - Heavy metals KW - Pollution effects KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40572154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Molecular+and+Toxicological+Responses+to+Mercurials+in+C.+elegans&rft.au=McElwee%2C+M+K%3BBoyd%2C+W+A%3BFreedman%2C+J+H&rft.aulast=McElwee&rft.aufirst=M&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dose-Response Analysis the Quantitative Challenge T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40571267; 4535077 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Portier, C J Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Dose-response effects KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40571267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Dose-Response+Analysis+the+Quantitative+Challenge&rft.au=Portier%2C+C+J&rft.aulast=Portier&rft.aufirst=C&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Centrosomal Amplification and Aneuploidy in Cultured Hamster Cells Exposed to Zidovudine (AZT) T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40570956; 4536639 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Olivero, O A AU - Ming, J M AU - Ward, Y AU - Semino-Mora, C AU - Robinson, E J AU - Borojerdi, J P AU - Cooch, C AU - Taylor, B J AU - Poirier, M C Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Zidovudine KW - Aneuploidy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40570956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Centrosomal+Amplification+and+Aneuploidy+in+Cultured+Hamster+Cells+Exposed+to+Zidovudine+%28AZT%29&rft.au=Olivero%2C+O+A%3BMing%2C+J+M%3BWard%2C+Y%3BSemino-Mora%2C+C%3BRobinson%2C+E+J%3BBorojerdi%2C+J+P%3BCooch%2C+C%3BTaylor%2C+B+J%3BPoirier%2C+M+C&rft.aulast=Olivero&rft.aufirst=O&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Dose Range-Finding Study to Determine the Hemodynamic Effects of a Single IV Infusion and a 14-Day Continuous Intravenous (CIV) of KSR-1 AS-214231 (NSC-731442) in Cynomolgus Monkeys T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40570518; 4535153 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Hassler, C R AU - Hawk, M AU - Lordo, R AU - Wood, B AU - Johnson, J AU - Kolesnick, R AU - Peggins, J Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Hemodynamics KW - Intravenous administration KW - Cynomolgus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40570518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=A+Dose+Range-Finding+Study+to+Determine+the+Hemodynamic+Effects+of+a+Single+IV+Infusion+and+a+14-Day+Continuous+Intravenous+%28CIV%29+of+KSR-1+AS-214231+%28NSC-731442%29+in+Cynomolgus+Monkeys&rft.au=Hassler%2C+C+R%3BHawk%2C+M%3BLordo%2C+R%3BWood%2C+B%3BJohnson%2C+J%3BKolesnick%2C+R%3BPeggins%2C+J&rft.aulast=Hassler&rft.aufirst=C&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mouse Metabolomics in the Search for Endogenous P450 Metabolites and Metabolic Profiling T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40570014; 4535047 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Gonzalez, F AU - Chen, C AU - Krausz, K AU - Idle, J Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Metabolites KW - Metabolomics KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40570014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Mouse+Metabolomics+in+the+Search+for+Endogenous+P450+Metabolites+and+Metabolic+Profiling&rft.au=Gonzalez%2C+F%3BChen%2C+C%3BKrausz%2C+K%3BIdle%2C+J&rft.aulast=Gonzalez&rft.aufirst=F&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Disposition and Metabolism of N-Butyl Glycidyl Ether in F344 Rats and B6C3F1 Mice T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40567495; 4536670 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Lebetkin, E H AU - Chen, L AU - Nwakpuda, E I AU - Sanders, M AU - Burka, L T Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Ethers KW - Metabolism KW - Mice KW - Rats KW - Disposition KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40567495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Disposition+and+Metabolism+of+N-Butyl+Glycidyl+Ether+in+F344+Rats+and+B6C3F1+Mice&rft.au=Lebetkin%2C+E+H%3BChen%2C+L%3BNwakpuda%2C+E+I%3BSanders%2C+M%3BBurka%2C+L+T&rft.aulast=Lebetkin&rft.aufirst=E&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Familial Interstitial Pneumonia (FIP) is Phenotypically and Genetically Heterogeneous. T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40567072; 4536725 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Wise, A AU - Steele, M P AU - Speer, M C AU - Loyd, J E AU - Brown, K K AU - Herron, A AU - Burch, L H AU - Schwarz, M I AU - Schwartz, D A Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Pneumonia KW - Interstitial environment KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40567072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Familial+Interstitial+Pneumonia+%28FIP%29+is+Phenotypically+and+Genetically+Heterogeneous.&rft.au=Wise%2C+A%3BSteele%2C+M+P%3BSpeer%2C+M+C%3BLoyd%2C+J+E%3BBrown%2C+K+K%3BHerron%2C+A%3BBurch%2C+L+H%3BSchwarz%2C+M+I%3BSchwartz%2C+D+A&rft.aulast=Wise&rft.aufirst=A&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Drinking Water Preconditioning on Dichloroacetic Acid (DCA) and Dibromoacetic Acid (DBA) Toxicokinetics (TK) in F344 Rats and B6C3F1 Mice T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40565912; 4536674 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Godfrey, V AU - Hong, S AU - Johnson, J D AU - Graves, S AU - Hawk, M AU - Merrill, J AU - Schultz, I AU - Smith, C Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Mice KW - Drinking water KW - Rats KW - Protein-tyrosine kinase KW - Dichloroacetic acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40565912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Effect+of+Drinking+Water+Preconditioning+on+Dichloroacetic+Acid+%28DCA%29+and+Dibromoacetic+Acid+%28DBA%29+Toxicokinetics+%28TK%29+in+F344+Rats+and+B6C3F1+Mice&rft.au=Godfrey%2C+V%3BHong%2C+S%3BJohnson%2C+J+D%3BGraves%2C+S%3BHawk%2C+M%3BMerrill%2C+J%3BSchultz%2C+I%3BSmith%2C+C&rft.aulast=Godfrey&rft.aufirst=V&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Application of a Quantitative HTS Approach for Accelerating Hit-to-Lead Process in Discovery of Glucocerebrosidase Inhibitors T2 - 233rd National Meeting and Exposition of the American Chemical Society AN - 40565544; 4539812 JF - 233rd National Meeting and Exposition of the American Chemical Society AU - Zheng, Wei AU - Padia, Janak K Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Glucosylceramidase KW - Inhibitors KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40565544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Application+of+a+Quantitative+HTS+Approach+for+Accelerating+Hit-to-Lead+Process+in+Discovery+of+Glucocerebrosidase+Inhibitors&rft.au=Zheng%2C+Wei%3BPadia%2C+Janak+K&rft.aulast=Zheng&rft.aufirst=Wei&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/233nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Carbohydrate Microarrays for Basic and Translational Cancer Research T2 - 233rd National Meeting and Exposition of the American Chemical Society AN - 40564425; 4539602 JF - 233rd National Meeting and Exposition of the American Chemical Society AU - Gildersleeve, Jeffrey C Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Cancer KW - Carbohydrates KW - Translation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40564425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Carbohydrate+Microarrays+for+Basic+and+Translational+Cancer+Research&rft.au=Gildersleeve%2C+Jeffrey+C&rft.aulast=Gildersleeve&rft.aufirst=Jeffrey&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=233rd+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/233nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Molecular Characterization of a Cadmium Inducible Transformer-2-Like Protein from the Nematode Caenorhabditis Elegans T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40562676; 4536607 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Tvermoes, B E AU - Cui, Y AU - Boyd, W AU - Snyder, D AU - Freedman, J H Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Nematodes KW - Cadmium KW - Nematoda KW - Caenorhabditis elegans KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40562676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=The+Molecular+Characterization+of+a+Cadmium+Inducible+Transformer-2-Like+Protein+from+the+Nematode+Caenorhabditis+Elegans&rft.au=Tvermoes%2C+B+E%3BCui%2C+Y%3BBoyd%2C+W%3BSnyder%2C+D%3BFreedman%2C+J+H&rft.aulast=Tvermoes&rft.aufirst=B&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Diffrerential Response of the Left and Median Liver Lobes to Toxic Challenge T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40562626; 4536601 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Irwin, R AU - Boorman, G A AU - Parker, J S AU - Lobenhofer, E K Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Liver KW - Toxicity KW - Animal physiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40562626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Diffrerential+Response+of+the+Left+and+Median+Liver+Lobes+to+Toxic+Challenge&rft.au=Irwin%2C+R%3BBoorman%2C+G+A%3BParker%2C+J+S%3BLobenhofer%2C+E+K&rft.aulast=Irwin&rft.aufirst=R&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acquired Androgen Independence during Cadmium-Induced Malignant Transformation of Human Prostate Epithelial Cells T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40561555; 4536603 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Benbrahin-Tallaa, L AU - Jie, L AU - Webber, M AU - Waalkes, M Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Epithelial cells KW - Prostate KW - Transformation KW - Androgens KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40561555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Acquired+Androgen+Independence+during+Cadmium-Induced+Malignant+Transformation+of+Human+Prostate+Epithelial+Cells&rft.au=Benbrahin-Tallaa%2C+L%3BJie%2C+L%3BWebber%2C+M%3BWaalkes%2C+M&rft.aulast=Benbrahin-Tallaa&rft.aufirst=L&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Environmental Influences on the Ovary and Hypothalamic Pituitary Gonadal Axis T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40561148; 4535708 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Jefferson, W N AU - Flaws, J Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Ovaries KW - Hypothalamus KW - Pituitary KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40561148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Environmental+Influences+on+the+Ovary+and+Hypothalamic+Pituitary+Gonadal+Axis&rft.au=Jefferson%2C+W+N%3BFlaws%2C+J&rft.aulast=Jefferson&rft.aufirst=W&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Thirteen Week Toxicity Study of Indole-3-Carbinol in B6C3F1 Mice and Fischer 344 Rats T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40560894; 4536409 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Wyde, M E AU - Bordelon, N R AU - Nyska, A AU - Mann, J AU - Hebert, C D AU - Bucher, J R Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Mice KW - Rats KW - Toxicity KW - Indole-3-carbinol KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40560894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Thirteen+Week+Toxicity+Study+of+Indole-3-Carbinol+in+B6C3F1+Mice+and+Fischer+344+Rats&rft.au=Wyde%2C+M+E%3BBordelon%2C+N+R%3BNyska%2C+A%3BMann%2C+J%3BHebert%2C+C+D%3BBucher%2C+J+R&rft.aulast=Wyde&rft.aufirst=M&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Utero Arsenic Exposure Enhances Skin Squamous Cell Carcinoma Formation and Induces Proliferative Lesions of the Urinary Bladder, Uterus and Adrenal in Tg.AC Mice T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40560620; 4536082 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Waalkes, M AU - Liu, J AU - Germolec, D AU - Ward, J AU - Diwan, B Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Skin KW - Mice KW - Lesions KW - Urine KW - Squamous cell carcinoma KW - Intrauterine exposure KW - Uterus KW - Urinary bladder KW - Arsenic KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40560620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=In+Utero+Arsenic+Exposure+Enhances+Skin+Squamous+Cell+Carcinoma+Formation+and+Induces+Proliferative+Lesions+of+the+Urinary+Bladder%2C+Uterus+and+Adrenal+in+Tg.AC+Mice&rft.au=Waalkes%2C+M%3BLiu%2C+J%3BGermolec%2C+D%3BWard%2C+J%3BDiwan%2C+B&rft.aulast=Waalkes&rft.aufirst=M&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microglia Mediate Deisel Exhaust Particles-Induce Dopaminergic Neurotoxicity: The Role of MAC1 T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40560404; 4536859 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Block, M AU - Wu, X. AU - Hong, J AU - Veronesi, B Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Particulates KW - Neurotoxicity KW - Exhausts KW - Microglia KW - Dopamine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40560404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Microglia+Mediate+Deisel+Exhaust+Particles-Induce+Dopaminergic+Neurotoxicity%3A+The+Role+of+MAC1&rft.au=Block%2C+M%3BWu%2C+X.%3BHong%2C+J%3BVeronesi%2C+B&rft.aulast=Block&rft.aufirst=M&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression and Immune System Susceptibility T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40560300; 4536860 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Germolec, D AU - Luebke, R Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Immune system KW - Gene expression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40560300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Gene+Expression+and+Immune+System+Susceptibility&rft.au=Germolec%2C+D%3BLuebke%2C+R&rft.aulast=Germolec&rft.aufirst=D&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Screening for Estrogen Receptor (ER alpha) Ligands using High Content Nuclear Translocation Analysis T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40559889; 4536189 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Dull, A AU - Martinez, E AU - Hager, G AU - McMahon, J Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Translocation KW - Estrogen receptors KW - Nuclear transport KW - Screening KW - Sex hormones KW - Ligands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40559889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Screening+for+Estrogen+Receptor+%28ER+alpha%29+Ligands+using+High+Content+Nuclear+Translocation+Analysis&rft.au=Dull%2C+A%3BMartinez%2C+E%3BHager%2C+G%3BMcMahon%2C+J&rft.aulast=Dull&rft.aufirst=A&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Brain PGE2 Concentration is Associated with Susceptibility to Kainate-Induced Seizures T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40559841; 4536170 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Toscano, C D AU - Bosetti, F Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Brain KW - Seizures KW - Prostaglandin E2 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40559841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Brain+PGE2+Concentration+is+Associated+with+Susceptibility+to+Kainate-Induced+Seizures&rft.au=Toscano%2C+C+D%3BBosetti%2C+F&rft.aulast=Toscano&rft.aufirst=C&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Nitric Oxide Prodrug, V-PYRRO/NO, Protects Against Arsenic Toxicity and Apoptosis at the Cellular Level T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40559834; 4536083 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Qu, W. AU - Liu, J AU - Fuquay, R AU - Saavedra, J AU - Keefer, L AU - Waalkes, M Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Nitric oxide KW - Toxicity KW - Apoptosis KW - Prodrugs KW - Arsenic KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40559834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=The+Nitric+Oxide+Prodrug%2C+V-PYRRO%2FNO%2C+Protects+Against+Arsenic+Toxicity+and+Apoptosis+at+the+Cellular+Level&rft.au=Qu%2C+W.%3BLiu%2C+J%3BFuquay%2C+R%3BSaavedra%2C+J%3BKeefer%2C+L%3BWaalkes%2C+M&rft.aulast=Qu&rft.aufirst=W.&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Comparative Sensitivity of the CD-1 Mouse, Fisher 344 Rat, and the CD Sprague Dawley Rat to the Phytoestrogen Genistein T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40558734; 4534904 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Caviness, G AU - Thigpen, J E AU - Helmich, A AU - Little, S AU - Whiteside, T AU - Locklear, J AU - Padilla-Banks, E AU - Grant, M AU - Forsythe, D Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Phytoestrogens KW - Genistein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40558734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=The+Comparative+Sensitivity+of+the+CD-1+Mouse%2C+Fisher+344+Rat%2C+and+the+CD+Sprague+Dawley+Rat+to+the+Phytoestrogen+Genistein&rft.au=Caviness%2C+G%3BThigpen%2C+J+E%3BHelmich%2C+A%3BLittle%2C+S%3BWhiteside%2C+T%3BLocklear%2C+J%3BPadilla-Banks%2C+E%3BGrant%2C+M%3BForsythe%2C+D&rft.aulast=Caviness&rft.aufirst=G&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Assessing the Health Effects of Dietary Supplements T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40558696; 4536878 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Coates, P M Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Dietary supplements KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40558696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Assessing+the+Health+Effects+of+Dietary+Supplements&rft.au=Coates%2C+P+M&rft.aulast=Coates&rft.aufirst=P&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Patterns of Differential Gene Expression in Liver following Hepatotoxicant Exposure T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40558649; 4536602 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Gerrish, K E AU - Paules, R S Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Liver KW - Gene expression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40558649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Patterns+of+Differential+Gene+Expression+in+Liver+following+Hepatotoxicant+Exposure&rft.au=Gerrish%2C+K+E%3BPaules%2C+R+S&rft.aulast=Gerrish&rft.aufirst=K&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Study of the Effects of Dichloroacetic Acid on the Metabolism and Disposition of Trichlororethylene in Cyp2e1-/- (KO) and Wild-Type (WT) Mice. T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40558169; 4535689 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Kim, D AU - Ghanayem, B I Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Metabolism KW - Mice KW - Disposition KW - Dichloroacetic acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40558169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Study+of+the+Effects+of+Dichloroacetic+Acid+on+the+Metabolism+and+Disposition+of+Trichlororethylene+in+Cyp2e1-%2F-+%28KO%29+and+Wild-Type+%28WT%29+Mice.&rft.au=Kim%2C+D%3BGhanayem%2C+B+I&rft.aulast=Kim&rft.aufirst=D&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of the Innate Immune System in the Increased Susceptibility of Interleukin-13 Deficient Mice to Acetaminophen-Induced Liver Disease T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40558147; 4535498 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Yee, S B AU - Bourdi, M AU - Masson, M AU - Pohl, L R Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Immune system KW - Mice KW - Liver diseases KW - Interleukin 13 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40558147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Role+of+the+Innate+Immune+System+in+the+Increased+Susceptibility+of+Interleukin-13+Deficient+Mice+to+Acetaminophen-Induced+Liver+Disease&rft.au=Yee%2C+S+B%3BBourdi%2C+M%3BMasson%2C+M%3BPohl%2C+L+R&rft.aulast=Yee&rft.aufirst=S&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Aminoglutethimide Metabolism by Myeloperoxidase Results in Protein Free Radical Formation that Correlates with Caspase Activation and Proteasome Inhibition: A Possible Mechanism of Agranulocytosis. T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40558052; 4534999 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Siraki, A AU - Mason, R P Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Metabolism KW - Caspase KW - Proteasomes KW - Protein turnover KW - Free radicals KW - Neutropenia KW - Peroxidase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40558052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Aminoglutethimide+Metabolism+by+Myeloperoxidase+Results+in+Protein+Free+Radical+Formation+that+Correlates+with+Caspase+Activation+and+Proteasome+Inhibition%3A+A+Possible+Mechanism+of+Agranulocytosis.&rft.au=Siraki%2C+A%3BMason%2C+R+P&rft.aulast=Siraki&rft.aufirst=A&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Diet and Helicobacter Hepaticus Infection on the Detection of Liver Carcinogenicity in B6C3F@@d1@ Mice Following Two-Year Dermal Exposure to Triethanolamine T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40558027; 4535464 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Stout, M D AU - Suarez, F A AU - Bucher, J R Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Infection KW - Diets KW - Mice KW - Carcinogenicity KW - Liver KW - Skin KW - Triethanolamine KW - Helicobacter hepaticus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40558027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Effect+of+Diet+and+Helicobacter+Hepaticus+Infection+on+the+Detection+of+Liver+Carcinogenicity+in+B6C3F%40%40d1%40+Mice+Following+Two-Year+Dermal+Exposure+to+Triethanolamine&rft.au=Stout%2C+M+D%3BSuarez%2C+F+A%3BBucher%2C+J+R&rft.aulast=Stout&rft.aufirst=M&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Variations in Phytoestrogen Content between different Mill Dates of the Same Diet Produces Significant Differences in the Time of Vaginal Opening in F344 Rats but not in CD Sprague Dawley Rats T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40557742; 4534905 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Thigpen, J E AU - Haseman, J AU - Setchell, K AU - Saunders, H AU - Caviness, G AU - Padilla-Banks, E AU - Grant, M AU - Forsythe, D Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Rats KW - Diets KW - Vagina KW - Phytoestrogens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40557742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Variations+in+Phytoestrogen+Content+between+different+Mill+Dates+of+the+Same+Diet+Produces+Significant+Differences+in+the+Time+of+Vaginal+Opening+in+F344+Rats+but+not+in+CD+Sprague+Dawley+Rats&rft.au=Thigpen%2C+J+E%3BHaseman%2C+J%3BSetchell%2C+K%3BSaunders%2C+H%3BCaviness%2C+G%3BPadilla-Banks%2C+E%3BGrant%2C+M%3BForsythe%2C+D&rft.aulast=Thigpen&rft.aufirst=J&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Arsenic-Induced Transformation of Human Urogenital Progenitor Cells T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40557655; 4535364 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Tokar, E AU - Webber, M AU - Waalkes, M Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Transformation KW - Stem cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40557655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Arsenic-Induced+Transformation+of+Human+Urogenital+Progenitor+Cells&rft.au=Tokar%2C+E%3BWebber%2C+M%3BWaalkes%2C+M&rft.aulast=Tokar&rft.aufirst=E&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Batch to Batch Variability in Estrogenic Activity in Commercial Animal Feed: Importance and Implications for Laboratory Animal Research T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40557498; 4534906 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Heindel, J J AU - vom Saal, F AU - Thigpen, J AU - Setchell, K AU - Yetley, E Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Laboratory testing KW - Animal feeds KW - Estrogens KW - Laboratory animals KW - Estrogenic activity KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40557498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Batch+to+Batch+Variability+in+Estrogenic+Activity+in+Commercial+Animal+Feed%3A+Importance+and+Implications+for+Laboratory+Animal+Research&rft.au=Heindel%2C+J+J%3Bvom+Saal%2C+F%3BThigpen%2C+J%3BSetchell%2C+K%3BYetley%2C+E&rft.aulast=Heindel&rft.aufirst=J&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NICEATM/ECVAM/JaCVAM Multi-phased International Validation Study of a Stably-Transfected Estrogen Receptor (ER) Transcriptional Activation (TA) Test Method T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40557387; 4535759 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Stokes, W AU - Bremer, S AU - Jacobs, M AU - Kojima, H AU - Ceger, P AU - Deal, F AU - Tice, R Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Estrogen receptors KW - Transcription activation KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40557387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=NICEATM%2FECVAM%2FJaCVAM+Multi-phased+International+Validation+Study+of+a+Stably-Transfected+Estrogen+Receptor+%28ER%29+Transcriptional+Activation+%28TA%29+Test+Method&rft.au=Stokes%2C+W%3BBremer%2C+S%3BJacobs%2C+M%3BKojima%2C+H%3BCeger%2C+P%3BDeal%2C+F%3BTice%2C+R&rft.aulast=Stokes&rft.aufirst=W&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Impact of Variation at the HLA and KIR Gene Clusters on HIV Disease T2 - 2007 Keystone Symposia on Molecular and Cellular Determinants of HIV Pathogenesis (X8) AN - 40557188; 4528331 JF - 2007 Keystone Symposia on Molecular and Cellular Determinants of HIV Pathogenesis (X8) AU - Carrington, Mary Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Histocompatibility antigen HLA KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40557188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Molecular+and+Cellular+Determinants+of+HIV+Pathogenesis+%28X8%29&rft.atitle=The+Impact+of+Variation+at+the+HLA+and+KIR+Gene+Clusters+on+HIV+Disease&rft.au=Carrington%2C+Mary&rft.aulast=Carrington&rft.aufirst=Mary&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Molecular+and+Cellular+Determinants+of+HIV+Pathogenesis+%28X8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 7&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Presumptive Human Carcinogens and their Mode of Action using Toxicogenetics T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40557111; 4536297 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - French, J E Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Carcinogens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40557111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Identification+of+Presumptive+Human+Carcinogens+and+their+Mode+of+Action+using+Toxicogenetics&rft.au=French%2C+J+E&rft.aulast=French&rft.aufirst=J&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toxicogenomics Applications of the Biomedical Investigation Database (BID) T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40556969; 4535774 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Fostel, J AU - Rashid, A AU - Choi, D AU - Ahmed, A AU - Howle, R AU - Waters, M Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Databases KW - BID protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Toxicogenomics+Applications+of+the+Biomedical+Investigation+Database+%28BID%29&rft.au=Fostel%2C+J%3BRashid%2C+A%3BChoi%2C+D%3BAhmed%2C+A%3BHowle%2C+R%3BWaters%2C+M&rft.aulast=Fostel&rft.aufirst=J&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Endocrine, Paracrine and Autocrine Actions of Estradiol in Ovarian Function T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40556879; 4535711 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Couse, J F Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Estradiol KW - Paracrine signalling KW - Autocrine signalling KW - Endocrinology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Endocrine%2C+Paracrine+and+Autocrine+Actions+of+Estradiol+in+Ovarian+Function&rft.au=Couse%2C+J+F&rft.aulast=Couse&rft.aufirst=J&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mouse Skin Inflammation by Lipopolysaccharide: Production of Hydroxyl- And Lipid-Derived Free Radicals Requires iNOS and Possibly Xanthine Oxidase. T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40556781; 4536005 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Kadiiska, M B AU - Nakai, K AU - Jiang, J AU - Stadler, K AU - Mason, R Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Skin KW - Nitric-oxide synthase KW - Xanthine oxidase KW - Lipopolysaccharides KW - Inflammation KW - Free radicals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Mouse+Skin+Inflammation+by+Lipopolysaccharide%3A+Production+of+Hydroxyl-+And+Lipid-Derived+Free+Radicals+Requires+iNOS+and+Possibly+Xanthine+Oxidase.&rft.au=Kadiiska%2C+M+B%3BNakai%2C+K%3BJiang%2C+J%3BStadler%2C+K%3BMason%2C+R&rft.aulast=Kadiiska&rft.aufirst=M&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Electron Tomography of Immunodeficiency Viruses and Structural Mechanisms of Cellular Entry T2 - 2007 Keystone Symposia on HIV Vaccines: From Basic Research to Clinical Trials (X7) AN - 40556762; 4528317 JF - 2007 Keystone Symposia on HIV Vaccines: From Basic Research to Clinical Trials (X7) AU - Subramaniam, Sriram Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Viruses KW - Immunodeficiency KW - Tomography KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials+%28X7%29&rft.atitle=Electron+Tomography+of+Immunodeficiency+Viruses+and+Structural+Mechanisms+of+Cellular+Entry&rft.au=Subramaniam%2C+Sriram&rft.aulast=Subramaniam&rft.aufirst=Sriram&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials+%28X7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 6&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chemical Selection for NTP's High Throughput Screening Initiative - Round 1 T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40556663; 4535738 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Smith, C S AU - Bucher, J AU - Dearry, A AU - Portier, C AU - Tice, R AU - Witt, K AU - Collins, B Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Chemical+Selection+for+NTP%27s+High+Throughput+Screening+Initiative+-+Round+1&rft.au=Smith%2C+C+S%3BBucher%2C+J%3BDearry%2C+A%3BPortier%2C+C%3BTice%2C+R%3BWitt%2C+K%3BCollins%2C+B&rft.aulast=Smith&rft.aufirst=C&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The National Toxicology Program (NTP) High Throughput Screening (HTS) Initiative: Current Status and Future Directions T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40556593; 4535737 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Tice, R R AU - Fostel, J AU - Smith, C S AU - Witt, K AU - Freedman, J H AU - Portier, C J AU - Dearry, A D AU - Bucher, J R Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Screening KW - Toxicology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=The+National+Toxicology+Program+%28NTP%29+High+Throughput+Screening+%28HTS%29+Initiative%3A+Current+Status+and+Future+Directions&rft.au=Tice%2C+R+R%3BFostel%2C+J%3BSmith%2C+C+S%3BWitt%2C+K%3BFreedman%2C+J+H%3BPortier%2C+C+J%3BDearry%2C+A+D%3BBucher%2C+J+R&rft.aulast=Tice&rft.aufirst=R&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A High-Throughput Method for Assessing Chemical Toxicity using a C. elegans Feeding Response Assay T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40556555; 4535735 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Boyd, W A AU - McBride, S J AU - Freedman, J H Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Feeding KW - Toxicity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=A+High-Throughput+Method+for+Assessing+Chemical+Toxicity+using+a+C.+elegans+Feeding+Response+Assay&rft.au=Boyd%2C+W+A%3BMcBride%2C+S+J%3BFreedman%2C+J+H&rft.aulast=Boyd&rft.aufirst=W&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Metabolism and Disposition of Single and Multiple Doses of Trichloroethylene (TCE) using Cyp2e1-/- (KO) and Wild-Type (WT) Mice. T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40556508; 4535688 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Ghanayem, B I AU - Kim, D Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Solvents KW - Metabolism KW - Mice KW - Trichloroethylene KW - Disposition KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Comparative+Metabolism+and+Disposition+of+Single+and+Multiple+Doses+of+Trichloroethylene+%28TCE%29+using+Cyp2e1-%2F-+%28KO%29+and+Wild-Type+%28WT%29+Mice.&rft.au=Ghanayem%2C+B+I%3BKim%2C+D&rft.aulast=Ghanayem&rft.aufirst=B&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oxidative DNA Damage Induced by Inorganic Arsenite Exposure Detected using the Immuno-spin Trapping Method T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40556401; 4536080 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Kojima, C AU - Tokar, E AU - Ramirez, D AU - Mason, R AU - Waalkes, M Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Arsenite KW - Trapping KW - DNA damage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Oxidative+DNA+Damage+Induced+by+Inorganic+Arsenite+Exposure+Detected+using+the+Immuno-spin+Trapping+Method&rft.au=Kojima%2C+C%3BTokar%2C+E%3BRamirez%2C+D%3BMason%2C+R%3BWaalkes%2C+M&rft.aulast=Kojima&rft.aufirst=C&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A High Dose of Genistein Induces Significant Apoptotic Cell Death in Normal Human Myometrial Cells (UtSMC), but not in Human Uterine Leiomyoma (UtLM) Cells T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40556386; 4535289 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Castro, L AU - Moore, A B AU - Yu, L. AU - Zheng, X AU - Sifre, M AU - Bortner, C D AU - Kissling, G E AU - Dixon, D Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Mortality KW - Myometrium KW - Cell death KW - Apoptosis KW - Uterus KW - Genistein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=A+High+Dose+of+Genistein+Induces+Significant+Apoptotic+Cell+Death+in+Normal+Human+Myometrial+Cells+%28UtSMC%29%2C+but+not+in+Human+Uterine+Leiomyoma+%28UtLM%29+Cells&rft.au=Castro%2C+L%3BMoore%2C+A+B%3BYu%2C+L.%3BZheng%2C+X%3BSifre%2C+M%3BBortner%2C+C+D%3BKissling%2C+G+E%3BDixon%2C+D&rft.aulast=Castro&rft.aufirst=L&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Metabolism and Disposition of Single and Multiple Doses of Acrylamide (AM) using Cyp2e1-/- (KO) and Wild-Type (WT) Mice. T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40556368; 4535687 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Bai, R AU - Hoffler, U AU - El-Hadri, L AU - Rahman, A AU - Ferguson, L AU - Ghanayem, B I Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Metabolism KW - Mice KW - Acrylamide KW - Disposition KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Comparative+Metabolism+and+Disposition+of+Single+and+Multiple+Doses+of+Acrylamide+%28AM%29+using+Cyp2e1-%2F-+%28KO%29+and+Wild-Type+%28WT%29+Mice.&rft.au=Bai%2C+R%3BHoffler%2C+U%3BEl-Hadri%2C+L%3BRahman%2C+A%3BFerguson%2C+L%3BGhanayem%2C+B+I&rft.aulast=Bai&rft.aufirst=R&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Blood Gene Expression Signatures Predict Exposure Levels T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40556356; 4536066 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Heinloth, A N AU - Bushel, P R AU - Li, J. AU - Huang, L AU - Chou, J W AU - Boorman, G A AU - Malarkey, D E AU - Houle, C D AU - Sandy, W M AU - Wilson, R E AU - Rickie, F D AU - Russo, M W AU - Watkins, P B AU - Tennant, R W AU - Paules, R S Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Gene expression KW - Blood KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Blood+Gene+Expression+Signatures+Predict+Exposure+Levels&rft.au=Heinloth%2C+A+N%3BBushel%2C+P+R%3BLi%2C+J.%3BHuang%2C+L%3BChou%2C+J+W%3BBoorman%2C+G+A%3BMalarkey%2C+D+E%3BHoule%2C+C+D%3BSandy%2C+W+M%3BWilson%2C+R+E%3BRickie%2C+F+D%3BRusso%2C+M+W%3BWatkins%2C+P+B%3BTennant%2C+R+W%3BPaules%2C+R+S&rft.aulast=Heinloth&rft.aufirst=A&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transcriptome Changes in HepG2 Cells Exposed to Copper: GO Analysis and Hierarchical Clustering T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40556349; 4535673 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Song, M AU - Freedman, J H Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Copper KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Transcriptome+Changes+in+HepG2+Cells+Exposed+to+Copper%3A+GO+Analysis+and+Hierarchical+Clustering&rft.au=Song%2C+M%3BFreedman%2C+J+H&rft.aulast=Song&rft.aufirst=M&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Glucocorticoid Receptor: One Gene, Many Proteins, Extensive Post Translational Modifications: Provide New Mechanisms for Tissue Specific Anti-inflammatory Actions of Glucocortocoids in Health and Disease T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40556211; 4535400 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Cidlowski, J A AU - Lu, N Z AU - Jewell, C M AU - Lewis-Tuffin, L J AU - Smoak, K AU - Zhou, J AU - Housley, P Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Translation KW - Glucocorticoid receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=The+Glucocorticoid+Receptor%3A+One+Gene%2C+Many+Proteins%2C+Extensive+Post+Translational+Modifications%3A+Provide+New+Mechanisms+for+Tissue+Specific+Anti-inflammatory+Actions+of+Glucocortocoids+in+Health+and+Disease&rft.au=Cidlowski%2C+J+A%3BLu%2C+N+Z%3BJewell%2C+C+M%3BLewis-Tuffin%2C+L+J%3BSmoak%2C+K%3BZhou%2C+J%3BHousley%2C+P&rft.aulast=Cidlowski&rft.aufirst=J&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Alternative and Integrated Approaches to Skin Sensitization: Recent Progress and the Way Forward T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40556012; 4535391 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Stokes, W S Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Skin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Alternative+and+Integrated+Approaches+to+Skin+Sensitization%3A+Recent+Progress+and+the+Way+Forward&rft.au=Stokes%2C+W+S&rft.aulast=Stokes&rft.aufirst=W&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Disruption of the Female Reproductive System by the Phytoestrogen Genistein: Subcutaneous Injection versus Oral Exposure T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40555965; 4535291 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Padilla-Banks, E AU - Jefferson, W AU - Newbold, R R Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Reproductive system KW - Phytoestrogens KW - Genistein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40555965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Disruption+of+the+Female+Reproductive+System+by+the+Phytoestrogen+Genistein%3A+Subcutaneous+Injection+versus+Oral+Exposure&rft.au=Padilla-Banks%2C+E%3BJefferson%2C+W%3BNewbold%2C+R+R&rft.aulast=Padilla-Banks&rft.aufirst=E&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fracture Prevention: Menopausal Hormone Therapy and Dietary Supplements (Ca + Vitamin D) T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40555935; 4536040 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - McGowan, J Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Prevention KW - Hormones KW - Dietary supplements KW - Vitamin D KW - Fractures KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40555935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Fracture+Prevention%3A+Menopausal+Hormone+Therapy+and+Dietary+Supplements+%28Ca+%2B+Vitamin+D%29&rft.au=McGowan%2C+J&rft.aulast=McGowan&rft.aufirst=J&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transplacental Exposure to Inorganic Arsenic at a Hepatocarcinogenic Dose Induces Fetal Gene Expression Changes Indicative of Aberrant Estrogen Signaling and Disrupted Steroid Metabolism T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40555754; 4534820 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Liu, J AU - Xie, Y AU - Cooper, F AU - Ducharme, D AU - Tennant, R AU - Diwan, B AU - Waalkes, M Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Steroid hormones KW - Metabolism KW - Estrogens KW - Signal transduction KW - Gene expression KW - Fetuses KW - Arsenic KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40555754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Transplacental+Exposure+to+Inorganic+Arsenic+at+a+Hepatocarcinogenic+Dose+Induces+Fetal+Gene+Expression+Changes+Indicative+of+Aberrant+Estrogen+Signaling+and+Disrupted+Steroid+Metabolism&rft.au=Liu%2C+J%3BXie%2C+Y%3BCooper%2C+F%3BDucharme%2C+D%3BTennant%2C+R%3BDiwan%2C+B%3BWaalkes%2C+M&rft.aulast=Liu&rft.aufirst=J&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Possible Interactions between Cellular Methyl Metabolism and Adaptive Efflux during Chronic Arsenic Exposure in Human Cells T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40555722; 4536081 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Coppin, J AU - Webber, M AU - Waalkes, M Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Metabolism KW - Arsenic KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40555722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Possible+Interactions+between+Cellular+Methyl+Metabolism+and+Adaptive+Efflux+during+Chronic+Arsenic+Exposure+in+Human+Cells&rft.au=Coppin%2C+J%3BWebber%2C+M%3BWaalkes%2C+M&rft.aulast=Coppin&rft.aufirst=J&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Developmental Exposure to Estrogens and Effects on Ovarian Maturation T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40555318; 4535710 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Jefferson, W Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Estrogens KW - Sex hormones KW - Sexual maturity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40555318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Developmental+Exposure+to+Estrogens+and+Effects+on+Ovarian+Maturation&rft.au=Jefferson%2C+W&rft.aulast=Jefferson&rft.aufirst=W&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of the Systemic Sensitization Potential of 2,3 Butanedione (Diacetyl)in Balb/C Mice T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40554478; 4535835 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Patterson, R M AU - Rebolloso, Y AU - Carey, M AU - Blackshear, P AU - Morgan, D AU - Germolec, D Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40554478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Evaluation+of+the+Systemic+Sensitization+Potential+of+2%2C3+Butanedione+%28Diacetyl%29in+Balb%2FC+Mice&rft.au=Patterson%2C+R+M%3BRebolloso%2C+Y%3BCarey%2C+M%3BBlackshear%2C+P%3BMorgan%2C+D%3BGermolec%2C+D&rft.aulast=Patterson&rft.aufirst=R&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microarray Analysis of Calcineurin Inhibitor Immunosuppressant-Mediated Nephrotoxicity in the Rat T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40554412; 4535969 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Auman, J T AU - Huang, Q AU - Jayadev, S AU - Blanchard, K AU - Paules, R S Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Calcineurin inhibitors KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40554412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Microarray+Analysis+of+Calcineurin+Inhibitor+Immunosuppressant-Mediated+Nephrotoxicity+in+the+Rat&rft.au=Auman%2C+J+T%3BHuang%2C+Q%3BJayadev%2C+S%3BBlanchard%2C+K%3BPaules%2C+R+S&rft.aulast=Auman&rft.aufirst=J&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effect of TLR Ligands on HIV-1 Replication in Human Lymphoid Tissue Ex Vivo: A Potential Mechanism of Co-Pathogenesis T2 - 2007 Keystone Symposia on Molecular and Cellular Determinants of HIV Pathogenesis (X8) AN - 40554269; 4528346 JF - 2007 Keystone Symposia on Molecular and Cellular Determinants of HIV Pathogenesis (X8) AU - Brichacek, Beda Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Replication KW - Lymphoid tissue KW - Ligands KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40554269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Molecular+and+Cellular+Determinants+of+HIV+Pathogenesis+%28X8%29&rft.atitle=The+Effect+of+TLR+Ligands+on+HIV-1+Replication+in+Human+Lymphoid+Tissue+Ex+Vivo%3A+A+Potential+Mechanism+of+Co-Pathogenesis&rft.au=Brichacek%2C+Beda&rft.aulast=Brichacek&rft.aufirst=Beda&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Molecular+and+Cellular+Determinants+of+HIV+Pathogenesis+%28X8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 7&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evidence of a Protective Role for Cytokine/Chemokine Production in HIV Infection T2 - 2007 Keystone Symposia on Molecular and Cellular Determinants of HIV Pathogenesis (X8) AN - 40554234; 4528344 JF - 2007 Keystone Symposia on Molecular and Cellular Determinants of HIV Pathogenesis (X8) AU - Casazza, Joe Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Infection KW - Cytokines KW - Chemokines KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40554234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Molecular+and+Cellular+Determinants+of+HIV+Pathogenesis+%28X8%29&rft.atitle=Evidence+of+a+Protective+Role+for+Cytokine%2FChemokine+Production+in+HIV+Infection&rft.au=Casazza%2C+Joe&rft.aulast=Casazza&rft.aufirst=Joe&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Molecular+and+Cellular+Determinants+of+HIV+Pathogenesis+%28X8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 7&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Biologically Relevant Genes using a Database of Rat Liver and Kidney Baseline Gene Expression T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40552870; 4535786 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Chou, J AU - Liu, J AU - Hester, S AU - Lee, J S AU - Thompson, K AU - Bass, M AU - Boedigheimer, M AU - Fostel, J AU - Liu, F AU - Wolfinger, R AU - Bushel, P AU - Corton, C Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Kidneys KW - Liver KW - Databases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40552870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Identification+of+Biologically+Relevant+Genes+using+a+Database+of+Rat+Liver+and+Kidney+Baseline+Gene+Expression&rft.au=Chou%2C+J%3BLiu%2C+J%3BHester%2C+S%3BLee%2C+J+S%3BThompson%2C+K%3BBass%2C+M%3BBoedigheimer%2C+M%3BFostel%2C+J%3BLiu%2C+F%3BWolfinger%2C+R%3BBushel%2C+P%3BCorton%2C+C&rft.aulast=Chou&rft.aufirst=J&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Down-Regulation of TGF-ss Pathway Genes, Activin a and Smad3, in Human Uterine Leiomyoma Cells Treated with a High Dose of Genistein T2 - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AN - 40552067; 4535290 JF - 46th Annual Meeting and ToxExpo of the Society of Toxicology (SOT 2007) AU - Di, X. AU - Ducharme, D M AU - Tucker, C J AU - Yu, L. AU - Zheng, X AU - Castro, L AU - Moore, A B AU - Hermon, T AU - Dixon, D Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Genistein KW - Uterus KW - Activin KW - Smad3 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40552067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.atitle=Down-Regulation+of+TGF-ss+Pathway+Genes%2C+Activin+a+and+Smad3%2C+in+Human+Uterine+Leiomyoma+Cells+Treated+with+a+High+Dose+of+Genistein&rft.au=Di%2C+X.%3BDucharme%2C+D+M%3BTucker%2C+C+J%3BYu%2C+L.%3BZheng%2C+X%3BCastro%2C+L%3BMoore%2C+A+B%3BHermon%2C+T%3BDixon%2C+D&rft.aulast=Di&rft.aufirst=X.&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+and+ToxExpo+of+the+Society+of+Toxicology+%28SOT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/ai/meet/am2007/it_planner.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clonal Correlates of Vaccine-Induced Immune Protection Against SIV in Rhesus Macaques T2 - 2007 Keystone Symposia on HIV Vaccines: From Basic Research to Clinical Trials (X7) AN - 40545408; 4528304 JF - 2007 Keystone Symposia on HIV Vaccines: From Basic Research to Clinical Trials (X7) AU - Asher, Tedi E Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Vaccines KW - Simian immunodeficiency virus KW - Macaca mulatta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40545408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials+%28X7%29&rft.atitle=Clonal+Correlates+of+Vaccine-Induced+Immune+Protection+Against+SIV+in+Rhesus+Macaques&rft.au=Asher%2C+Tedi+E&rft.aulast=Asher&rft.aufirst=Tedi&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials+%28X7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 6&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Epitope-Scaffold Immunogens: Design, Characterization, and Molecular Mimicry of the 2F5 Epitope T2 - 2007 Keystone Symposia on HIV Vaccines: From Basic Research to Clinical Trials (X7) AN - 40545314; 4528280 JF - 2007 Keystone Symposia on HIV Vaccines: From Basic Research to Clinical Trials (X7) AU - Ofek, Gilad A Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Epitopes KW - Mimicry KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40545314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials+%28X7%29&rft.atitle=Epitope-Scaffold+Immunogens%3A+Design%2C+Characterization%2C+and+Molecular+Mimicry+of+the+2F5+Epitope&rft.au=Ofek%2C+Gilad+A&rft.aulast=Ofek&rft.aufirst=Gilad&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials+%28X7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 6&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prime/Boost HIV Vaccine Strategies Based on Replication Competent Adenovirus Recombinants T2 - 2007 Keystone Symposia on HIV Vaccines: From Basic Research to Clinical Trials (X7) AN - 40544806; 4528274 JF - 2007 Keystone Symposia on HIV Vaccines: From Basic Research to Clinical Trials (X7) AU - Robert-Guroff, Marjorie Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Vaccines KW - Replication KW - Recombinants KW - Disease control KW - Human immunodeficiency virus KW - Adenovirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40544806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials+%28X7%29&rft.atitle=Prime%2FBoost+HIV+Vaccine+Strategies+Based+on+Replication+Competent+Adenovirus+Recombinants&rft.au=Robert-Guroff%2C+Marjorie&rft.aulast=Robert-Guroff&rft.aufirst=Marjorie&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials+%28X7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 6&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pushing the Envelope of HIV Vaccines: From Basic Research to Clinical Trials T2 - 2007 Keystone Symposia on HIV Vaccines: From Basic Research to Clinical Trials (X7) AN - 40544145; 4528290 JF - 2007 Keystone Symposia on HIV Vaccines: From Basic Research to Clinical Trials (X7) AU - Nabel, Gary J Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Clinical trials KW - Vaccines KW - Envelopes KW - Disease control KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40544145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials+%28X7%29&rft.atitle=Pushing+the+Envelope+of+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials&rft.au=Nabel%2C+Gary+J&rft.aulast=Nabel&rft.aufirst=Gary&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials+%28X7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 6&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Structural Approach to Vaccine Design T2 - 2007 Keystone Symposia on HIV Vaccines: From Basic Research to Clinical Trials (X7) AN - 40544043; 4528291 JF - 2007 Keystone Symposia on HIV Vaccines: From Basic Research to Clinical Trials (X7) AU - Kwong, Peter D Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Vaccines KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40544043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials+%28X7%29&rft.atitle=A+Structural+Approach+to+Vaccine+Design&rft.au=Kwong%2C+Peter+D&rft.aulast=Kwong&rft.aufirst=Peter&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials+%28X7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 6&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evolution of Cytomegalovirus-Specific CD4+ T Cell Clonotypes In Vivo: Vaccine Design Informed by Successful Immune Responses T2 - 2007 Keystone Symposia on HIV Vaccines: From Basic Research to Clinical Trials (X7) AN - 40543642; 4528298 JF - 2007 Keystone Symposia on HIV Vaccines: From Basic Research to Clinical Trials (X7) AU - Price, David A Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Vaccines KW - Lymphocytes T KW - CD4 antigen KW - Evolution KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40543642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials+%28X7%29&rft.atitle=Evolution+of+Cytomegalovirus-Specific+CD4%2B+T+Cell+Clonotypes+In+Vivo%3A+Vaccine+Design+Informed+by+Successful+Immune+Responses&rft.au=Price%2C+David+A&rft.aulast=Price&rft.aufirst=David&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials+%28X7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 6&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Epitope Specific Neutralizing Antibody Responses T2 - 2007 Keystone Symposia on HIV Vaccines: From Basic Research to Clinical Trials (X7) AN - 40543556; 4528278 JF - 2007 Keystone Symposia on HIV Vaccines: From Basic Research to Clinical Trials (X7) AU - Mascola, John R Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Epitopes KW - Antibodies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40543556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials+%28X7%29&rft.atitle=Epitope+Specific+Neutralizing+Antibody+Responses&rft.au=Mascola%2C+John+R&rft.aulast=Mascola&rft.aufirst=John&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials+%28X7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 6&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activity of an Affordable Fusion Inhibiting Peptide T2 - 2007 Keystone Symposia on HIV Vaccines: From Basic Research to Clinical Trials (X7) AN - 40543312; 4528288 JF - 2007 Keystone Symposia on HIV Vaccines: From Basic Research to Clinical Trials (X7) AU - Richards, Christopher J Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40543312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials+%28X7%29&rft.atitle=Activity+of+an+Affordable+Fusion+Inhibiting+Peptide&rft.au=Richards%2C+Christopher+J&rft.aulast=Richards&rft.aufirst=Christopher&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials+%28X7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 6&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Diminished Proliferative Capacity of HIV-Specific CD8+ T Cells is Not Restored by Antiretroviral Therapy or Exogenous IL-2 T2 - 2007 Keystone Symposia on HIV Vaccines: From Basic Research to Clinical Trials (X7) AN - 40542610; 4528312 JF - 2007 Keystone Symposia on HIV Vaccines: From Basic Research to Clinical Trials (X7) AU - Migueles, Stephen A Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Antiretroviral agents KW - Interleukin 2 KW - CD8 antigen KW - Lymphocytes T KW - Antiretroviral therapy KW - Therapy KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40542610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials+%28X7%29&rft.atitle=Diminished+Proliferative+Capacity+of+HIV-Specific+CD8%2B+T+Cells+is+Not+Restored+by+Antiretroviral+Therapy+or+Exogenous+IL-2&rft.au=Migueles%2C+Stephen+A&rft.aulast=Migueles&rft.aufirst=Stephen&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials+%28X7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 6&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microbial Translocation is a Cause of Systemic Immune Activation in Chronic HIV Infection T2 - 2007 Keystone Symposia on HIV Vaccines: From Basic Research to Clinical Trials (X7) AN - 40542175; 4528303 JF - 2007 Keystone Symposia on HIV Vaccines: From Basic Research to Clinical Trials (X7) AU - Brenchley, Jason M Y1 - 2007/03/25/ PY - 2007 DA - 2007 Mar 25 KW - Translocation KW - Infection KW - Chronic infection KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40542175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials+%28X7%29&rft.atitle=Microbial+Translocation+is+a+Cause+of+Systemic+Immune+Activation+in+Chronic+HIV+Infection&rft.au=Brenchley%2C+Jason+M&rft.aulast=Brenchley&rft.aufirst=Jason&rft.date=2007-03-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+HIV+Vaccines%3A+From+Basic+Research+to+Clinical+Trials+%28X7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 6&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Morphologic Spectrum of Smooth Muscle Tumors in the Hereditary Leimyomatosis and Renal Cell Cancer Syndrome. Its Clinical Significance T2 - 96th Annual Meeting of the United States and Canadian Academy of Pathology AN - 40655092; 4574469 JF - 96th Annual Meeting of the United States and Canadian Academy of Pathology AU - Val, D AU - Stratton, P AU - Neumann, R D AU - Linehan, W M AU - Merino, M J Y1 - 2007/03/24/ PY - 2007 DA - 2007 Mar 24 KW - Cancer KW - Smooth muscle KW - Tumors KW - Kidneys KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40655092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=The+Morphologic+Spectrum+of+Smooth+Muscle+Tumors+in+the+Hereditary+Leimyomatosis+and+Renal+Cell+Cancer+Syndrome.+Its+Clinical+Significance&rft.au=Val%2C+D%3BStratton%2C+P%3BNeumann%2C+R+D%3BLinehan%2C+W+M%3BMerino%2C+M+J&rft.aulast=Val&rft.aufirst=D&rft.date=2007-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://test.pathologyportal.org/newindex.htm?96th/index.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clonal Relationship between Follicular Lymphoma and Histiocytic/Dendritic Cell Neoplasms Occurring in the Same Patient T2 - 96th Annual Meeting of the United States and Canadian Academy of Pathology AN - 40652954; 4573847 JF - 96th Annual Meeting of the United States and Canadian Academy of Pathology AU - Feldman, A L AU - Arber, D A AU - Raffeld, M AU - Burke, J S AU - Pittaluga, S AU - Warnke, R AU - Jaffe, E S Y1 - 2007/03/24/ PY - 2007 DA - 2007 Mar 24 KW - Lymphoma KW - Dendritic cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40652954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=Clonal+Relationship+between+Follicular+Lymphoma+and+Histiocytic%2FDendritic+Cell+Neoplasms+Occurring+in+the+Same+Patient&rft.au=Feldman%2C+A+L%3BArber%2C+D+A%3BRaffeld%2C+M%3BBurke%2C+J+S%3BPittaluga%2C+S%3BWarnke%2C+R%3BJaffe%2C+E+S&rft.aulast=Feldman&rft.aufirst=A&rft.date=2007-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://test.pathologyportal.org/newindex.htm?96th/index.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a Unique Epigenetic Sub-Microenvironment in Prostate Cancer T2 - 96th Annual Meeting of the United States and Canadian Academy of Pathology AN - 40645621; 4575106 JF - 96th Annual Meeting of the United States and Canadian Academy of Pathology AU - Rodriguez-Canales, J AU - Hanson, J C AU - Tangrea, M A AU - Erickson, H S AU - Albert, P A AU - Wallis, B S AU - Richardson, A M AU - Pinto, P A AU - Linehan, W M AU - Gillespie, J W AU - Merino, M J AU - Libutti, S K AU - Woodson, K W AU - Emmert-Buck, M R AU - Chuaqui, R F Y1 - 2007/03/24/ PY - 2007 DA - 2007 Mar 24 KW - Prostate cancer KW - Epigenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40645621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=Identification+of+a+Unique+Epigenetic+Sub-Microenvironment+in+Prostate+Cancer&rft.au=Rodriguez-Canales%2C+J%3BHanson%2C+J+C%3BTangrea%2C+M+A%3BErickson%2C+H+S%3BAlbert%2C+P+A%3BWallis%2C+B+S%3BRichardson%2C+A+M%3BPinto%2C+P+A%3BLinehan%2C+W+M%3BGillespie%2C+J+W%3BMerino%2C+M+J%3BLibutti%2C+S+K%3BWoodson%2C+K+W%3BEmmert-Buck%2C+M+R%3BChuaqui%2C+R+F&rft.aulast=Rodriguez-Canales&rft.aufirst=J&rft.date=2007-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://test.pathologyportal.org/newindex.htm?96th/index.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Morphologic Changes in Prostate Cancer Samples Following Intraprostatic PSA-Based Vaccine Administration T2 - 96th Annual Meeting of the United States and Canadian Academy of Pathology AN - 40645180; 4575376 JF - 96th Annual Meeting of the United States and Canadian Academy of Pathology AU - Val, D AU - Gulley, J L AU - Pinto, P AU - Schlom, J AU - Linehan, W M AU - Merino, M J Y1 - 2007/03/24/ PY - 2007 DA - 2007 Mar 24 KW - Vaccines KW - Prostate cancer KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40645180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=Morphologic+Changes+in+Prostate+Cancer+Samples+Following+Intraprostatic+PSA-Based+Vaccine+Administration&rft.au=Val%2C+D%3BGulley%2C+J+L%3BPinto%2C+P%3BSchlom%2C+J%3BLinehan%2C+W+M%3BMerino%2C+M+J&rft.aulast=Val&rft.aufirst=D&rft.date=2007-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://test.pathologyportal.org/newindex.htm?96th/index.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Gene Amplification and Protein Expression of Epidermal Growth Factor Receptor (EGFR) by CISH, FISH and IHC in Lung Adenocarcinoma (ADC) T2 - 96th Annual Meeting of the United States and Canadian Academy of Pathology AN - 40644495; 4574772 JF - 96th Annual Meeting of the United States and Canadian Academy of Pathology AU - Silva, A AU - Carter, D AU - Begnami, M AU - Henschke, C I AU - Vasquez, M AU - Merino, M J Y1 - 2007/03/24/ PY - 2007 DA - 2007 Mar 24 KW - Lung KW - Pisces KW - Growth factors KW - Epidermal growth factor receptors KW - Gene amplification KW - Fluorescence in situ hybridization KW - Adenocarcinoma KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40644495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=Evaluation+of+Gene+Amplification+and+Protein+Expression+of+Epidermal+Growth+Factor+Receptor+%28EGFR%29+by+CISH%2C+FISH+and+IHC+in+Lung+Adenocarcinoma+%28ADC%29&rft.au=Silva%2C+A%3BCarter%2C+D%3BBegnami%2C+M%3BHenschke%2C+C+I%3BVasquez%2C+M%3BMerino%2C+M+J&rft.aulast=Silva&rft.aufirst=A&rft.date=2007-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://test.pathologyportal.org/newindex.htm?96th/index.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression of XIAP Protein in Neuroblastomas and Ewing Sarcoma Family Tumors T2 - 96th Annual Meeting of the United States and Canadian Academy of Pathology AN - 40643363; 4574535 JF - 96th Annual Meeting of the United States and Canadian Academy of Pathology AU - Galli, S B AU - Tsokos, M Y1 - 2007/03/24/ PY - 2007 DA - 2007 Mar 24 KW - Ewing's sarcoma KW - Tumors KW - XIAP protein KW - Neuroblastoma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40643363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=Expression+of+XIAP+Protein+in+Neuroblastomas+and+Ewing+Sarcoma+Family+Tumors&rft.au=Galli%2C+S+B%3BTsokos%2C+M&rft.aulast=Galli&rft.aufirst=S&rft.date=2007-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://test.pathologyportal.org/newindex.htm?96th/index.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Chromosome 7 Alterations Including Epidermal Growth Factor Amplification Status in Pediatric Meningiomas T2 - 96th Annual Meeting of the United States and Canadian Academy of Pathology AN - 40643004; 4575472 JF - 96th Annual Meeting of the United States and Canadian Academy of Pathology AU - Begnami, M AU - Santi, M AU - Rushing, E J AU - Quezado, M Y1 - 2007/03/24/ PY - 2007 DA - 2007 Mar 24 KW - Growth factors KW - Chromosomes KW - Pediatrics KW - Meningioma KW - Chromosome 7 KW - Epidermal growth factor KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40643004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=Evaluation+of+Chromosome+7+Alterations+Including+Epidermal+Growth+Factor+Amplification+Status+in+Pediatric+Meningiomas&rft.au=Begnami%2C+M%3BSanti%2C+M%3BRushing%2C+E+J%3BQuezado%2C+M&rft.aulast=Begnami&rft.aufirst=M&rft.date=2007-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://test.pathologyportal.org/newindex.htm?96th/index.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Nucleic Acid Index (NAI) in the Spectrum of Thyroid Lesions T2 - 96th Annual Meeting of the United States and Canadian Academy of Pathology AN - 40642362; 4575013 JF - 96th Annual Meeting of the United States and Canadian Academy of Pathology AU - Begnami, M AU - Quezado, M AU - Wincovitch, S AU - Garfield, S AU - Merino, M J Y1 - 2007/03/24/ PY - 2007 DA - 2007 Mar 24 KW - Nucleic acids KW - Lesions KW - Thyroid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40642362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=Evaluation+of+Nucleic+Acid+Index+%28NAI%29+in+the+Spectrum+of+Thyroid+Lesions&rft.au=Begnami%2C+M%3BQuezado%2C+M%3BWincovitch%2C+S%3BGarfield%2C+S%3BMerino%2C+M+J&rft.aulast=Begnami&rft.aufirst=M&rft.date=2007-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://test.pathologyportal.org/newindex.htm?96th/index.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Benign Pulmonary and Chest Wall Lesions as Part of the Von Hippel Lindau Syndrome Mimicking Metastatic Renal Cell Carcinoma T2 - 96th Annual Meeting of the United States and Canadian Academy of Pathology AN - 40638357; 4573955 JF - 96th Annual Meeting of the United States and Canadian Academy of Pathology AU - Merino, M J AU - Carter, D AU - Linehan, W M AU - Nguyen, D AU - Quezado, M Y1 - 2007/03/24/ PY - 2007 DA - 2007 Mar 24 KW - Lesions KW - Benign KW - Chest KW - Renal cell carcinoma KW - Metastases KW - Mimicry KW - Tumors KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40638357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=Novel+Benign+Pulmonary+and+Chest+Wall+Lesions+as+Part+of+the+Von+Hippel+Lindau+Syndrome+Mimicking+Metastatic+Renal+Cell+Carcinoma&rft.au=Merino%2C+M+J%3BCarter%2C+D%3BLinehan%2C+W+M%3BNguyen%2C+D%3BQuezado%2C+M&rft.aulast=Merino&rft.aufirst=M&rft.date=2007-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://test.pathologyportal.org/newindex.htm?96th/index.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chromosome 7 Polysomy Detected by Chromogenic in Situ Hybridization is a Common Finding in Sporadic Chordomas T2 - 96th Annual Meeting of the United States and Canadian Academy of Pathology AN - 40636671; 4574032 JF - 96th Annual Meeting of the United States and Canadian Academy of Pathology AU - Begnami, M D AU - Soares, F A AU - Quezado, M Y1 - 2007/03/24/ PY - 2007 DA - 2007 Mar 24 KW - Chromosomes KW - Chromosome 7 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40636671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=Chromosome+7+Polysomy+Detected+by+Chromogenic+in+Situ+Hybridization+is+a+Common+Finding+in+Sporadic+Chordomas&rft.au=Begnami%2C+M+D%3BSoares%2C+F+A%3BQuezado%2C+M&rft.aulast=Begnami&rft.aufirst=M&rft.date=2007-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://test.pathologyportal.org/newindex.htm?96th/index.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pathologic and Molecular Features of Screening Spiral Computed Tomography-Detected Lung Cancers T2 - 96th Annual Meeting of the United States and Canadian Academy of Pathology AN - 40633403; 4573948 JF - 96th Annual Meeting of the United States and Canadian Academy of Pathology AU - Pelosi, G AU - Veronesi, G AU - Fabbri, A AU - Thunnissen, E AU - Viale, G Y1 - 2007/03/24/ PY - 2007 DA - 2007 Mar 24 KW - Lung cancer KW - Computed tomography KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40633403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=96th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.atitle=Pathologic+and+Molecular+Features+of+Screening+Spiral+Computed+Tomography-Detected+Lung+Cancers&rft.au=Pelosi%2C+G%3BVeronesi%2C+G%3BFabbri%2C+A%3BThunnissen%2C+E%3BViale%2C+G&rft.aulast=Pelosi&rft.aufirst=G&rft.date=2007-03-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=96th+Annual+Meeting+of+the+United+States+and+Canadian+Academy+of+Pathology&rft.issn=&rft_id=info:doi/ L2 - http://test.pathologyportal.org/newindex.htm?96th/index.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Wide Ranging Functions of Small RNAs in Bacteria T2 - 2007 Keystone Symposia on Systems Biology and Regulatory Networks (X5) AN - 40546811; 4530729 JF - 2007 Keystone Symposia on Systems Biology and Regulatory Networks (X5) AU - Storz, Gisela T Y1 - 2007/03/22/ PY - 2007 DA - 2007 Mar 22 KW - Post-transcription KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40546811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Systems+Biology+and+Regulatory+Networks+%28X5%29&rft.atitle=Wide+Ranging+Functions+of+Small+RNAs+in+Bacteria&rft.au=Storz%2C+Gisela+T&rft.aulast=Storz&rft.aufirst=Gisela&rft.date=2007-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Systems+Biology+and+Regulatory+Networks+%28X5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=87 0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism AN - 21334543; 11934650 AB - Rapamycin and several analogs, such as CCI-779 and RAD001, are currently undergoing clinical evaluation as anticancer agents. In this study, we show that inhibition of mammalian target of rapamycin (mTOR) signaling by rapamycin leads to an increase of Akt phosphorylation in Rh30 and RD human rhabdomyosarcoma cell lines and xenografts, and insulin-like growth factor (IGF)-II-treated C2C12 mouse myoblasts and IGF-II-overexpressing Chinese hamster ovary cells. RNA interference-mediated knockdown of S6K1 also results in an increase of Akt phosphorylation. These data suggest that mTOR/S6K1 inhibition either by rapamycin or small interfering RNA (siRNA) triggers a negative feedback loop, resulting in the activation of Akt signaling. We next sought to investigate the mechanism of this negative feedback regulation from mTOR to Akt. Suppression of insulin receptor substrate (IRS)-1 and tuberous sclerosis complex-1 by siRNAs failed to abrogate rapamycin-induced upregulation of Akt phosphorylation in both Rh30 and RD cells. However, pretreatment with h7C10 antibody directed against insulin-like growth factor-1 receptor (IGF-1R) led to a blockade of rapamycin-induced Akt activation. Combined mTOR and IGF-1R inhibition with rapamycin and h7C10 antibody, respectively, resulted in additive inhibition of cell growth and survival. These data suggest that rapamycin mediates Akt activation through an IGF-1R-dependent mechanism. Thus, combining an mTOR inhibitor and an IGF-1R antibody/inhibitor may be an appropriate strategy to enhance mTOR-targeted anticancer therapy.Oncogene (2007) 26, 1932-1940. doi:10.1038/sj.onc.1209990; published online 25 September 2006 JF - Oncogene AU - Wan, X AU - Harkavy, B AU - Shen, N AU - Grohar, P AU - Helman, L J AD - 1 Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, MD, USA Y1 - 2007/03/22/ PY - 2007 DA - 2007 Mar 22 SP - 1932 EP - 1940 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 26 IS - 13 SN - 0950-9232, 0950-9232 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Oncogenes & Growth Factors Abstracts KW - Cell survival KW - tuberous sclerosis KW - Insulin-like growth factor I KW - Data processing KW - Insulin receptors KW - Antitumor agents KW - Antibodies KW - Phosphorylation KW - siRNA KW - Insulin-like growth factors KW - AKT protein KW - Myoblasts KW - Feedback KW - Xenografts KW - TOR protein KW - Rapamycin KW - Rhabdomyosarcoma KW - Signal transduction KW - B 26600:Tyrosine Kinase Activity KW - W 30915:Pharmaceuticals & Vaccines KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21334543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Rapamycin+induces+feedback+activation+of+Akt+signaling+through+an+IGF-1R-dependent+mechanism&rft.au=Wan%2C+X%3BHarkavy%2C+B%3BShen%2C+N%3BGrohar%2C+P%3BHelman%2C+L+J&rft.aulast=Wan&rft.aufirst=X&rft.date=2007-03-22&rft.volume=26&rft.issue=13&rft.spage=1932&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/10.1038%2Fsj.onc.1209990 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - tuberous sclerosis; Cell survival; Insulin-like growth factor I; Data processing; Antitumor agents; Insulin receptors; Antibodies; siRNA; Phosphorylation; Insulin-like growth factors; Myoblasts; AKT protein; Feedback; Xenografts; TOR protein; Rapamycin; Signal transduction; Rhabdomyosarcoma DO - http://dx.doi.org/10.1038/sj.onc.1209990 ER - TY - JOUR T1 - N- and C-terminal residues of eIF1A have opposing effects on the fidelity of start codon selection. AN - 70296838; 17332751 AB - Translation initiation factor eIF1A stimulates preinitiation complex (PIC) assembly and scanning, but the molecular mechanisms of its functions are not understood. We show that the F131A,F133A mutation in the C-terminal tail (CTT) of eIF1A impairs recruitment of the eIF2-GTP-Met-tRNA(i)(Met) ternary complex to 40S subunits, eliminating functional coupling with eIF1. Mutating residues 17-21 in the N-terminal tail (NTT) of eIF1A also reduces PIC assembly, but in a manner rescued by eIF1. Interestingly, the 131,133 CTT mutation enhances initiation at UUG codons (Sui(-) phenotype) and decreases leaky scanning at AUG, while the NTT mutation 17-21 suppresses the Sui(-) phenotypes of eIF5 and eIF2beta mutations and increases leaky scanning. These findings and the opposite effects of the mutations on eIF1A binding to reconstituted PICs suggest that the NTT mutations promote an open, scanning-conducive conformation of the PIC, whereas the CTT mutations 131,133 have the reverse effect. We conclude that tight binding of eIF1A to the PIC is an important determinant of AUG selection and is modulated in opposite directions by residues in the NTT and CTT of eIF1A. JF - The EMBO journal AU - Fekete, Christie A AU - Mitchell, Sarah F AU - Cherkasova, Vera A AU - Applefield, Drew AU - Algire, Mikkel A AU - Maag, David AU - Saini, Adesh K AU - Lorsch, Jon R AU - Hinnebusch, Alan G AD - Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA. Y1 - 2007/03/21/ PY - 2007 DA - 2007 Mar 21 SP - 1602 EP - 1614 VL - 26 IS - 6 SN - 0261-4189, 0261-4189 KW - Codon, Initiator KW - 0 KW - Eukaryotic Initiation Factor-1 KW - RNA, Transfer, Met KW - Saccharomyces cerevisiae Proteins KW - eukaryotic peptide initiation factor-1A KW - Index Medicus KW - Ribosomes -- metabolism KW - RNA, Transfer, Met -- metabolism KW - Mutation, Missense -- genetics KW - Mutagenesis KW - Saccharomyces cerevisiae -- genetics KW - Saccharomyces cerevisiae Proteins -- metabolism KW - Saccharomyces cerevisiae -- metabolism KW - Codon, Initiator -- genetics KW - Saccharomyces cerevisiae Proteins -- genetics KW - Eukaryotic Initiation Factor-1 -- metabolism KW - Protein Biosynthesis -- genetics KW - Saccharomyces cerevisiae Proteins -- biosynthesis KW - Eukaryotic Initiation Factor-1 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70296838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+EMBO+journal&rft.atitle=N-+and+C-terminal+residues+of+eIF1A+have+opposing+effects+on+the+fidelity+of+start+codon+selection.&rft.au=Fekete%2C+Christie+A%3BMitchell%2C+Sarah+F%3BCherkasova%2C+Vera+A%3BApplefield%2C+Drew%3BAlgire%2C+Mikkel+A%3BMaag%2C+David%3BSaini%2C+Adesh+K%3BLorsch%2C+Jon+R%3BHinnebusch%2C+Alan+G&rft.aulast=Fekete&rft.aufirst=Christie&rft.date=2007-03-21&rft.volume=26&rft.issue=6&rft.spage=1602&rft.isbn=&rft.btitle=&rft.title=The+EMBO+journal&rft.issn=02614189&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-24 N1 - Date created - 2007-03-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2004 Jul 23;279(30):31910-20 [15145951] Genes Dev. 2003 Nov 15;17(22):2786-97 [14600024] Genes Dev. 1997 Sep 15;11(18):2396-413 [9308967] Nature. 1998 Aug 27;394(6696):854-9 [9732867] Genes Dev. 2004 Dec 15;18(24):3078-93 [15601822] Mol Cell. 2005 Jan 21;17(2):265-75 [15664195] RNA. 2005 Apr;11(4):470-86 [15703437] Mol Cell Biol. 2005 Jul;25(13):5480-91 [15964804] Annu Rev Microbiol. 2005;59:407-50 [16153175] EMBO J. 2005 Oct 19;24(20):3588-601 [16193068] Mol Cell. 2005 Oct 28;20(2):251-62 [16246727] J Mol Biol. 2006 Feb 24;356(3):724-37 [16380131] Mol Cell Biol. 2006 Feb;26(4):1355-72 [16449648] Mol Cell. 2000 Jan;5(1):109-19 [10678173] Mol Cell Biol. 2000 Aug;20(16):6019-29 [10913184] EMBO J. 2001 May 1;20(9):2326-37 [11331597] RNA. 2002 Mar;8(3):382-97 [12008673] EMBO J. 2002 Nov 1;21(21):5886-98 [12411506] Genes Dev. 2002 Nov 15;16(22):2906-22 [12435632] EMBO J. 2003 Jan 15;22(2):193-204 [12514125] J Biol Chem. 2003 Feb 21;278(8):6580-7 [12493757] Cold Spring Harb Symp Quant Biol. 2001;66:403-15 [12762043] J Mol Biol. 2003 Jul 25;330(5):917-24 [12860115] Mol Cell Biol. 2004 Nov;24(21):9437-55 [15485912] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Veillonellae Selectively Recognize Streptococcal Galb1-3GalNAc-containing Coaggregation Receptor Polysaccharides T2 - 85th General Session and Exhibition of the International Association for Dental Research, 36th Annual Meeting of the American Association for Dental Research and 31st Annual Meeting of the CADR AN - 40549785; 4533179 JF - 85th General Session and Exhibition of the International Association for Dental Research, 36th Annual Meeting of the American Association for Dental Research and 31st Annual Meeting of the CADR AU - Palmer Jr., R. AU - Ruhl, S AU - Kolenbrander, P E AU - Cisar, J O Y1 - 2007/03/21/ PY - 2007 DA - 2007 Mar 21 KW - Polysaccharides KW - Streptococcus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40549785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=85th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research%2C+36th+Annual+Meeting+of+the+American+Association+for+Dental+Research+and+31st+Annual+Meeting+of+the+CADR&rft.atitle=Veillonellae+Selectively+Recognize+Streptococcal+Galb1-3GalNAc-containing+Coaggregation+Receptor+Polysaccharides&rft.au=Palmer+Jr.%2C+R.%3BRuhl%2C+S%3BKolenbrander%2C+P+E%3BCisar%2C+J+O&rft.aulast=Palmer+Jr.&rft.aufirst=R.&rft.date=2007-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=85th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research%2C+36th+Annual+Meeting+of+the+American+Association+for+Dental+Research+and+31st+Annual+Meeting+of+the+CADR&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2007orleans/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Competition and Cooperation between Streptococcus Gordonii and Actinomyces Naeslundii T2 - 85th General Session and Exhibition of the International Association for Dental Research, 36th Annual Meeting of the American Association for Dental Research and 31st Annual Meeting of the CADR AN - 40549721; 4533166 JF - 85th General Session and Exhibition of the International Association for Dental Research, 36th Annual Meeting of the American Association for Dental Research and 31st Annual Meeting of the CADR AU - Jakubovics, N AU - Kolenbrander, P E Y1 - 2007/03/21/ PY - 2007 DA - 2007 Mar 21 KW - Competition KW - Cooperation KW - Streptococcus gordonii KW - Actinomyces naeslundii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40549721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=85th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research%2C+36th+Annual+Meeting+of+the+American+Association+for+Dental+Research+and+31st+Annual+Meeting+of+the+CADR&rft.atitle=Competition+and+Cooperation+between+Streptococcus+Gordonii+and+Actinomyces+Naeslundii&rft.au=Jakubovics%2C+N%3BKolenbrander%2C+P+E&rft.aulast=Jakubovics&rft.aufirst=N&rft.date=2007-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=85th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research%2C+36th+Annual+Meeting+of+the+American+Association+for+Dental+Research+and+31st+Annual+Meeting+of+the+CADR&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2007orleans/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression Profiling in Cultured Normal and Hereditary Gingival Fibromatosis Fibroblasts T2 - 85th General Session and Exhibition of the International Association for Dental Research, 36th Annual Meeting of the American Association for Dental Research and 31st Annual Meeting of the CADR AN - 40549574; 4532086 JF - 85th General Session and Exhibition of the International Association for Dental Research, 36th Annual Meeting of the American Association for Dental Research and 31st Annual Meeting of the CADR AU - Hart, P S AU - Jang, S.-I. AU - Pallos, D AU - Brahim, J S AU - Hart, T C Y1 - 2007/03/21/ PY - 2007 DA - 2007 Mar 21 KW - Fibroblasts KW - Hereditary gingival fibromatosis KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40549574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=85th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research%2C+36th+Annual+Meeting+of+the+American+Association+for+Dental+Research+and+31st+Annual+Meeting+of+the+CADR&rft.atitle=Expression+Profiling+in+Cultured+Normal+and+Hereditary+Gingival+Fibromatosis+Fibroblasts&rft.au=Hart%2C+P+S%3BJang%2C+S.-I.%3BPallos%2C+D%3BBrahim%2C+J+S%3BHart%2C+T+C&rft.aulast=Hart&rft.aufirst=P&rft.date=2007-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=85th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research%2C+36th+Annual+Meeting+of+the+American+Association+for+Dental+Research+and+31st+Annual+Meeting+of+the+CADR&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2007orleans/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of Radiation-Induced Mucositis Model with Single and Fractionated Irradiation T2 - 85th General Session and Exhibition of the International Association for Dental Research, 36th Annual Meeting of the American Association for Dental Research and 31st Annual Meeting of the CADR AN - 40549339; 4533793 JF - 85th General Session and Exhibition of the International Association for Dental Research, 36th Annual Meeting of the American Association for Dental Research and 31st Annual Meeting of the CADR AU - Cotrim, A P AU - Voutetakis, A AU - Samuni, Y AU - Sowers, A AU - Mitchell, J B AU - Baum, B J Y1 - 2007/03/21/ PY - 2007 DA - 2007 Mar 21 KW - Irradiation KW - Radiation KW - Mucositis KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40549339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=85th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research%2C+36th+Annual+Meeting+of+the+American+Association+for+Dental+Research+and+31st+Annual+Meeting+of+the+CADR&rft.atitle=Development+of+Radiation-Induced+Mucositis+Model+with+Single+and+Fractionated+Irradiation&rft.au=Cotrim%2C+A+P%3BVoutetakis%2C+A%3BSamuni%2C+Y%3BSowers%2C+A%3BMitchell%2C+J+B%3BBaum%2C+B+J&rft.aulast=Cotrim&rft.aufirst=A&rft.date=2007-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=85th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research%2C+36th+Annual+Meeting+of+the+American+Association+for+Dental+Research+and+31st+Annual+Meeting+of+the+CADR&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2007orleans/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cellular and transgenic mouse studies of mutant DLX3 T2 - 85th General Session and Exhibition of the International Association for Dental Research, 36th Annual Meeting of the American Association for Dental Research and 31st Annual Meeting of the CADR AN - 40548749; 4531966 JF - 85th General Session and Exhibition of the International Association for Dental Research, 36th Annual Meeting of the American Association for Dental Research and 31st Annual Meeting of the CADR AU - Choi, S J AU - Song, I S AU - Ryu, O H AU - Hart, P S AU - Wright, J T AU - Hart, T C Y1 - 2007/03/21/ PY - 2007 DA - 2007 Mar 21 KW - Mutants KW - Transgenic mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40548749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=85th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research%2C+36th+Annual+Meeting+of+the+American+Association+for+Dental+Research+and+31st+Annual+Meeting+of+the+CADR&rft.atitle=Cellular+and+transgenic+mouse+studies+of+mutant+DLX3&rft.au=Choi%2C+S+J%3BSong%2C+I+S%3BRyu%2C+O+H%3BHart%2C+P+S%3BWright%2C+J+T%3BHart%2C+T+C&rft.aulast=Choi&rft.aufirst=S&rft.date=2007-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=85th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research%2C+36th+Annual+Meeting+of+the+American+Association+for+Dental+Research+and+31st+Annual+Meeting+of+the+CADR&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2007orleans/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hyper-IgE Syndrome: Craniofacial Assessment using 3D Morphometrics and Conventional Cephalometrics T2 - 85th General Session and Exhibition of the International Association for Dental Research, 36th Annual Meeting of the American Association for Dental Research and 31st Annual Meeting of the CADR AN - 40548427; 4532137 JF - 85th General Session and Exhibition of the International Association for Dental Research, 36th Annual Meeting of the American Association for Dental Research and 31st Annual Meeting of the CADR AU - Council, S AU - Zia, A AU - Freeman, A F AU - Davis, J AU - Puck, J M AU - Holland, S M AU - Hart, T C AU - Domingo, D L Y1 - 2007/03/21/ PY - 2007 DA - 2007 Mar 21 KW - Job's syndrome KW - Animal morphology KW - Morphometry KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40548427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=85th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research%2C+36th+Annual+Meeting+of+the+American+Association+for+Dental+Research+and+31st+Annual+Meeting+of+the+CADR&rft.atitle=Hyper-IgE+Syndrome%3A+Craniofacial+Assessment+using+3D+Morphometrics+and+Conventional+Cephalometrics&rft.au=Council%2C+S%3BZia%2C+A%3BFreeman%2C+A+F%3BDavis%2C+J%3BPuck%2C+J+M%3BHolland%2C+S+M%3BHart%2C+T+C%3BDomingo%2C+D+L&rft.aulast=Council&rft.aufirst=S&rft.date=2007-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=85th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research%2C+36th+Annual+Meeting+of+the+American+Association+for+Dental+Research+and+31st+Annual+Meeting+of+the+CADR&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2007orleans/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Protein Profiling of TMJ Fluid by LC- And 2D- MS T2 - 85th General Session and Exhibition of the International Association for Dental Research, 36th Annual Meeting of the American Association for Dental Research and 31st Annual Meeting of the CADR AN - 40547974; 4533602 JF - 85th General Session and Exhibition of the International Association for Dental Research, 36th Annual Meeting of the American Association for Dental Research and 31st Annual Meeting of the CADR AU - Ryu, O H AU - Israel, H AU - Hart, T C Y1 - 2007/03/21/ PY - 2007 DA - 2007 Mar 21 KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40547974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=85th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research%2C+36th+Annual+Meeting+of+the+American+Association+for+Dental+Research+and+31st+Annual+Meeting+of+the+CADR&rft.atitle=Protein+Profiling+of+TMJ+Fluid+by+LC-+And+2D-+MS&rft.au=Ryu%2C+O+H%3BIsrael%2C+H%3BHart%2C+T+C&rft.aulast=Ryu&rft.aufirst=O&rft.date=2007-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=85th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research%2C+36th+Annual+Meeting+of+the+American+Association+for+Dental+Research+and+31st+Annual+Meeting+of+the+CADR&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2007orleans/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hutchinson-Gilford Progeria Syndrome: Oral-Craniofacial Phenotypes T2 - 85th General Session and Exhibition of the International Association for Dental Research, 36th Annual Meeting of the American Association for Dental Research and 31st Annual Meeting of the CADR AN - 40547948; 4532057 JF - 85th General Session and Exhibition of the International Association for Dental Research, 36th Annual Meeting of the American Association for Dental Research and 31st Annual Meeting of the CADR AU - Domingo, D L AU - Trujillo, M I AU - Guadagnini, J.-P. AU - Gordon, L AU - Merideth, M AU - Introne, W J AU - Gahl, W A AU - Hart, T C Y1 - 2007/03/21/ PY - 2007 DA - 2007 Mar 21 KW - Progeria KW - Phenotypes KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40547948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=85th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research%2C+36th+Annual+Meeting+of+the+American+Association+for+Dental+Research+and+31st+Annual+Meeting+of+the+CADR&rft.atitle=Hutchinson-Gilford+Progeria+Syndrome%3A+Oral-Craniofacial+Phenotypes&rft.au=Domingo%2C+D+L%3BTrujillo%2C+M+I%3BGuadagnini%2C+J.-P.%3BGordon%2C+L%3BMerideth%2C+M%3BIntrone%2C+W+J%3BGahl%2C+W+A%3BHart%2C+T+C&rft.aulast=Domingo&rft.aufirst=D&rft.date=2007-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=85th+General+Session+and+Exhibition+of+the+International+Association+for+Dental+Research%2C+36th+Annual+Meeting+of+the+American+Association+for+Dental+Research+and+31st+Annual+Meeting+of+the+CADR&rft.issn=&rft_id=info:doi/ L2 - http://iadr.confex.com/iadr/2007orleans/techprogram/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Vinorelbine plus 3-weekly trastuzumab in metastatic breast cancer: a single-centre phase 2 trial. AN - 70319810; 17374151 AB - After two studies reporting response rates higher than 70% in HER2-positive metastatic breast cancer with weekly trastuzumab and vinorelbine, we planned a phase 2 study to test activity of the same combination, with trastuzumab given every 3 weeks. Patients with HER2-positive metastatic breast cancer (3+ at immunohistochemistry or positive at fluorescence in situ hybridization), PS < or =2, normal left-ventricular ejection fraction (LVEF) and no more than one chemotherapy line for metastatic disease were eligible. Vinorelbine (30 mg/m2) was given on days 1 & 8 every 21 and trastuzumab (8 mg/kg day 1, then 6 mg/kg) every 21 days). A single-stage phase 2 design, with p0 = 0.45, p1 = 0.65, type I and II error = 0.10, was applied; 22 objective responses were required in 39 patients. From Nov 2002 to May 2005, 50 patients were enrolled, with a median age of 54 years (range 31-81). Among 40 patients eligible for response assessment, there were 7 complete and 13 partial responses (overall response rate 50%; 95% exact CI 33.8-66.2); 11 patients had disease stabilization, lasting more than 6 months in 10 cases. Response rate did not vary according to patients and tumor characteristics, type and amount of previous chemotherapy. Within the whole series, median progression-free survival was 9.6 months (95% CI 7.3-12.3), median overall survival 22.7 months (95% CI 19.5-NA). Fifteen patients (30%) developed brain metastases at a median time of 12 months (range 1-25). There was one toxic death due to renal failure in a patient receiving concomitant pamidronate. Twenty-three patients (46%) had grade 3-4 neutropenia, 2 (4%) grade 3 anemia, 4 (8%) febrile neutropenia. Two patients stopped treatment because of grade 2 decline of LVEF and one patient because of grade 2 liver toxicity concomitant with a grade 1 decline of LVEF. One patient stopped trastuzumab after 50 cycles because of grade 1 decline of LVEF. Although lower than in initial studies, activity of 3-weekly trastuzumab plus vinorelbine fell within the range of results reported with weekly schedules. Toxicity was prevalently manageable. This combination is safe and active for metastatic breast cancer patients who received adjuvant taxanes with anthracyclines. JF - BMC cancer AU - De Maio, Ermelinda AU - Pacilio, Carmen AU - Gravina, Adriano AU - Morabito, Alessandro AU - Di Rella, Francesca AU - Labonia, Vincenzo AU - Landi, Gabriella AU - Nuzzo, Francesco AU - Rossi, Emanuela AU - Silvestro, Pasqualina AU - Botti, Gerardo AU - Di Bonito, Maurizio AU - Curcio, Maria Pia AU - Formichelli, Franca AU - La Vecchia, Franca AU - Staiano, Maria AU - Maurea, Nicola AU - D'Aiuto, Giuseppe AU - D'Aiuto, Massimiliano AU - Thomas, Renato AU - Signoriello, Giuseppe AU - Perrone, Francesco AU - de Matteis, Andrea AD - Clinical Trials Unit, National Cancer Institute, Via M, Semmola, I-80131 Naples, Italy. linda.demaio@uosc.fondazionepascale.it Y1 - 2007/03/20/ PY - 2007 DA - 2007 Mar 20 SP - 50 VL - 7 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Vinblastine KW - 5V9KLZ54CY KW - Trastuzumab KW - P188ANX8CK KW - vinorelbine KW - Q6C979R91Y KW - Index Medicus KW - Drug Monitoring -- methods KW - Drug Administration Schedule KW - Genes, erbB-2 KW - Dose-Response Relationship, Drug KW - Humans KW - Fatigue -- chemically induced KW - Neutropenia -- chemically induced KW - Aged KW - Constipation -- chemically induced KW - Brain Neoplasms -- secondary KW - Aged, 80 and over KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Abdominal Pain -- chemically induced KW - Female KW - Survival Analysis KW - Breast Neoplasms -- genetics KW - Breast Neoplasms -- drug therapy KW - Vinblastine -- analogs & derivatives KW - Breast Neoplasms -- pathology KW - Vinblastine -- administration & dosage KW - Antibodies, Monoclonal -- adverse effects KW - Vinblastine -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Antibodies, Monoclonal -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70319810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+cancer&rft.atitle=Vinorelbine+plus+3-weekly+trastuzumab+in+metastatic+breast+cancer%3A+a+single-centre+phase+2+trial.&rft.au=De+Maio%2C+Ermelinda%3BPacilio%2C+Carmen%3BGravina%2C+Adriano%3BMorabito%2C+Alessandro%3BDi+Rella%2C+Francesca%3BLabonia%2C+Vincenzo%3BLandi%2C+Gabriella%3BNuzzo%2C+Francesco%3BRossi%2C+Emanuela%3BSilvestro%2C+Pasqualina%3BBotti%2C+Gerardo%3BDi+Bonito%2C+Maurizio%3BCurcio%2C+Maria+Pia%3BFormichelli%2C+Franca%3BLa+Vecchia%2C+Franca%3BStaiano%2C+Maria%3BMaurea%2C+Nicola%3BD%27Aiuto%2C+Giuseppe%3BD%27Aiuto%2C+Massimiliano%3BThomas%2C+Renato%3BSignoriello%2C+Giuseppe%3BPerrone%2C+Francesco%3Bde+Matteis%2C+Andrea&rft.aulast=De+Maio&rft.aufirst=Ermelinda&rft.date=2007-03-20&rft.volume=7&rft.issue=&rft.spage=50&rft.isbn=&rft.btitle=&rft.title=BMC+cancer&rft.issn=1471-2407&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-01 N1 - Date created - 2007-03-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Oncol. 1992 Jul;10(7):1049-56 [1351538] Cancer. 1978 Feb;41(2):776-83 [630551] Cancer Res. 1998 Jul 1;58(13):2825-31 [9661897] Oncogene. 1999 Apr 1;18(13):2241-51 [10327070] J Clin Oncol. 2005 Apr 1;23(10):2162-71 [15800309] J Clin Oncol. 2005 Jul 1;23(19):4265-74 [15911866] Ann Oncol. 2005 Nov;16(11):1772-7 [16150805] N Engl J Med. 2005 Oct 20;353(16):1659-72 [16236737] N Engl J Med. 2005 Oct 20;353(16):1673-84 [16236738] Cancer Chemother Pharmacol. 2006 May;57(5):554-8 [16133525] N Engl J Med. 2006 Dec 28;355(26):2733-43 [17192538] Ann Oncol. 2007 Jul;18(7):1152-8 [17264064] J Natl Cancer Inst. 2000 Feb 2;92(3):205-16 [10655437] N Engl J Med. 2001 Mar 15;344(11):783-92 [11248153] J Clin Pathol. 2000 Dec;53(12):890-2 [11265171] Ann Oncol. 2001 Mar;12(3):353-6 [11332148] J Clin Oncol. 2001 May 15;19(10):2722-30 [11352965] J Clin Oncol. 2002 Jul 15;20(14):3106-13 [12118024] Oncologist. 2002;7(5):410-7 [12401903] Cancer. 2003 Jun 15;97(12):2972-7 [12784331] J Clin Oncol. 2003 Nov 1;21(21):3965-71 [14507946] Eur J Cancer. 2004 Feb;40(3):379-82 [14746856] J Natl Cancer Inst. 2004 May 19;96(10):739-49 [15150302] J Clin Oncol. 2004 Sep 1;22(17):3608-17 [15337811] J Clin Oncol. 1998 Apr;16(4):1340-9 [9552035] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of genetic alterations in cancer-related genes in lung and brain tumors from B6C3F1 mice exposed to 1,3-butadiene or chloroprene. AN - 70282909; 16860786 AB - 1,3-Butadiene and chloroprene are multisite carcinogens in B6C3F1 mice with the strongest tumor response being the induction of lung neoplasms in females. Incidence of brain tumors in mice exposed to 1,3-butadiene was equivocal. This article reviews the efforts of our laboratory and others to uncover the mechanisms of butadiene and chloroprene induced lung and brain tumor responses in the B6C3F1 mouse. The formation of lung tumors by these chemicals involved mutations in the K-ras cancer gene and loss of heterozygosity in the region of K-ras on distal chromosome 6, while alterations in p53 and p16 were implicated in brain tumorigenesis. JF - Chemico-biological interactions AU - Ton, Thai-Vu AU - Hong, Hue-Hua AU - Devereux, Theodora R AU - Melnick, Ronald L AU - Sills, Robert C AU - Kim, Yongbaek AD - Environmental Toxicology Program and Environmental Carcinogenesis Program, National Institute of Environmental Health Sciences, MD B3-08, 111 Alexander Drive, Research Triangle Park, NC 27709, USA. ton@niehs.nih.gov Y1 - 2007/03/20/ PY - 2007 DA - 2007 Mar 20 SP - 112 EP - 120 VL - 166 IS - 1-3 SN - 0009-2797, 0009-2797 KW - Butadienes KW - 0 KW - Carcinogens KW - DNA Adducts KW - Chloroprene KW - 126-99-8 KW - 1,3-butadiene KW - JSD5FGP5VD KW - Index Medicus KW - Genes, ras KW - Animals KW - Alleles KW - Inhalation Exposure KW - Humans KW - Mice KW - Loss of Heterozygosity -- drug effects KW - DNA Adducts -- drug effects KW - Chromosomes, Mammalian -- drug effects KW - Male KW - Female KW - DNA Adducts -- metabolism KW - Mutagenesis -- drug effects KW - Genes, Neoplasm -- genetics KW - Carcinogens -- administration & dosage KW - Butadienes -- toxicity KW - Brain Neoplasms -- genetics KW - Carcinogens -- toxicity KW - Lung Neoplasms -- genetics KW - Chloroprene -- toxicity KW - Butadienes -- administration & dosage KW - Lung Neoplasms -- chemically induced KW - Chloroprene -- administration & dosage KW - Brain Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70282909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Evaluation+of+genetic+alterations+in+cancer-related+genes+in+lung+and+brain+tumors+from+B6C3F1+mice+exposed+to+1%2C3-butadiene+or+chloroprene.&rft.au=Ton%2C+Thai-Vu%3BHong%2C+Hue-Hua%3BDevereux%2C+Theodora+R%3BMelnick%2C+Ronald+L%3BSills%2C+Robert+C%3BKim%2C+Yongbaek&rft.aulast=Ton&rft.aufirst=Thai-Vu&rft.date=2007-03-20&rft.volume=166&rft.issue=1-3&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=00092797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-23 N1 - Date created - 2007-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - NIAID's Extramural TB Program - Contributions to TB Science and Vaccine Development T2 - 2007 Keystone Symposia on Tuberculosis: From Lab Research to Field Trials (C6) AN - 40543450; 4528246 JF - 2007 Keystone Symposia on Tuberculosis: From Lab Research to Field Trials (C6) AU - Sizemore, Christine F Y1 - 2007/03/20/ PY - 2007 DA - 2007 Mar 20 KW - Vaccines KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40543450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Tuberculosis%3A+From+Lab+Research+to+Field+Trials+%28C6%29&rft.atitle=NIAID%27s+Extramural+TB+Program+-+Contributions+to+TB+Science+and+Vaccine+Development&rft.au=Sizemore%2C+Christine+F&rft.aulast=Sizemore&rft.aufirst=Christine&rft.date=2007-03-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Tuberculosis%3A+From+Lab+Research+to+Field+Trials+%28C6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 8&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cellular Dynamics of Granuloma Formation and Maintenance Revealed by Intravital Imaging T2 - 2007 Keystone Symposia on Tuberculosis: From Lab Research to Field Trials (C6) AN - 40542507; 4528237 JF - 2007 Keystone Symposia on Tuberculosis: From Lab Research to Field Trials (C6) AU - Sher, Alan Y1 - 2007/03/20/ PY - 2007 DA - 2007 Mar 20 KW - Imaging techniques KW - Granuloma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40542507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Tuberculosis%3A+From+Lab+Research+to+Field+Trials+%28C6%29&rft.atitle=Cellular+Dynamics+of+Granuloma+Formation+and+Maintenance+Revealed+by+Intravital+Imaging&rft.au=Sher%2C+Alan&rft.aulast=Sher&rft.aufirst=Alan&rft.date=2007-03-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Tuberculosis%3A+From+Lab+Research+to+Field+Trials+%28C6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 8&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Metabolism in Latent Tuberculosis T2 - 2007 Keystone Symposia on Tuberculosis: From Lab Research to Field Trials (C6) AN - 40542425; 4528220 JF - 2007 Keystone Symposia on Tuberculosis: From Lab Research to Field Trials (C6) AU - Boshoff, Helena I M Y1 - 2007/03/20/ PY - 2007 DA - 2007 Mar 20 KW - Tuberculosis KW - Metabolism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40542425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Tuberculosis%3A+From+Lab+Research+to+Field+Trials+%28C6%29&rft.atitle=Metabolism+in+Latent+Tuberculosis&rft.au=Boshoff%2C+Helena+I+M&rft.aulast=Boshoff&rft.aufirst=Helena+I&rft.date=2007-03-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Tuberculosis%3A+From+Lab+Research+to+Field+Trials+%28C6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 8&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Chromatin-dependent cooperativity between site-specific transcription factors in vivo. AN - 70257684; 17186943 AB - Accessing binding sites in DNA wrapped around histones in condensed chromatin is an obstacle that transcription factors must overcome to regulate gene expression. Here we demonstrate cooperativity between two transcription factors, the glucocorticoid receptor (GR) and nuclear factor 1 (NF1) to bind the mouse mammary tumor virus promoter organized as regular chromatin in vivo. This cooperativity is not observed when the promoter is introduced transiently into cells. Using RNA interference to deplete NF1 protein levels in the cells, we confirmed that NF1 promotes binding of GR to the promoter. Furthermore, we observed a similar synergism between GR and NF1 binding on the endogenous 11beta-hydroxysteroid dehydrogenase promoter, also regulated by GR and NF1. Our results suggest that the chromatin architecture of the promoters does not permit strong association of GR in the absence of NF1. Therefore we propose that cooperativity among DNA binding factors in binding to their cognate recognition sites in chromatin may be an important feature in the regulation of gene expression. JF - The Journal of biological chemistry AU - Hebbar, Pratibha B AU - Archer, Trevor K AD - Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/03/16/ PY - 2007 DA - 2007 Mar 16 SP - 8284 EP - 8291 VL - 282 IS - 11 SN - 0021-9258, 0021-9258 KW - Chromatin KW - 0 KW - NFI Transcription Factors KW - Protein Isoforms KW - RNA, Small Interfering KW - Receptors, Glucocorticoid KW - Transcription Factors KW - Index Medicus KW - Animals KW - Transcription Factors -- metabolism KW - Humans KW - Mice KW - Models, Biological KW - Protein Binding KW - RNA, Small Interfering -- metabolism KW - Receptors, Glucocorticoid -- metabolism KW - Binding Sites KW - Promoter Regions, Genetic KW - Transfection KW - Chromatin Immunoprecipitation KW - RNA Interference KW - Chromatin -- metabolism KW - NFI Transcription Factors -- metabolism KW - Gene Expression Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70257684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Chromatin-dependent+cooperativity+between+site-specific+transcription+factors+in+vivo.&rft.au=Hebbar%2C+Pratibha+B%3BArcher%2C+Trevor+K&rft.aulast=Hebbar&rft.aufirst=Pratibha&rft.date=2007-03-16&rft.volume=282&rft.issue=11&rft.spage=8284&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-24 N1 - Date created - 2007-03-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 2000 Feb 18;287(5456):1262-5 [10678832] Genes Dev. 2006 Mar 15;20(6):689-99 [16543221] J Struct Biol. 2000 Apr;129(2-3):102-22 [10806063] EMBO J. 2000 May 15;19(10):2315-22 [10811622] Gene. 2000 May 16;249(1-2):31-45 [10831836] J Biol Chem. 2000 Jun 30;275(26):20061-8 [10751396] Mol Cell Biol. 2000 Sep;20(17):6466-75 [10938123] Adv Exp Med Biol. 2000;480:117-22 [10959417] Biochem Soc Trans. 2000;28(4):405-10 [10961929] J Biol Chem. 2001 Oct 26;276(43):39885-91 [11518712] Cell. 2002 Feb 22;108(4):475-87 [11909519] Mol Endocrinol. 2002 Jun;16(6):1204-14 [12040008] Mol Cell Biol. 2003 Feb;23(3):887-98 [12529394] Mol Cell Biol. 2003 Mar;23(5):1623-32 [12588982] Chromosoma. 2003 May;111(8):495-504 [12743713] Mol Cell Biol. 2003 Aug;23(16):5867-81 [12897156] J Mammary Gland Biol Neoplasia. 2003 Apr;8(2):241-54 [14635798] Cell. 2003 Dec 12;115(6):751-63 [14675539] Biochim Biophys Acta. 2004 Mar 15;1677(1-3):58-63 [15020046] Mol Cell Biol. 2004 Apr;24(8):3347-58 [15060156] J Clin Invest. 2004 Oct;114(8):1146-57 [15489962] Science. 1992 Mar 20;255(5051):1573-6 [1347958] Mol Cell Biol. 1993 Apr;13(4):2031-40 [8455596] J Steroid Biochem Mol Biol. 1995 Jun;53(1-6):33-5 [7626475] Genes Dev. 1995 Dec 15;9(24):3051-66 [8543151] J Biol Chem. 1996 Jan 5;271(1):153-9 [8550551] Methods. 1997 Feb;11(2):235-45 [8993036] Mol Cell Biol. 1997 Feb;17(2):895-905 [9001244] J Biol Chem. 1998 Jan 9;273(2):1175-83 [9422784] Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15603-8 [15501915] J Clin Endocrinol Metab. 2004 Nov;89(11):5614-21 [15531519] J Biol Chem. 2004 Dec 31;279(53):55520-30 [15471882] Mol Cell Biol. 2005 Jan;25(2):685-98 [15632069] Cell. 2005 Jul 15;122(1):33-43 [16009131] Mol Endocrinol. 2006 Mar;20(3):560-72 [16239257] Curr Opin Genet Dev. 2000 Apr;10(2):187-92 [10753786] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Oral fluid as an alternative matrix to monitor opiate and cocaine use in substance-abuse treatment patients AN - 57077835; 200720374 AB - Interest in oral fluid as an alternative matrix for monitoring drug use is due to its ease-of-collection and non-invasiveness; however, limited data are available on the disposition of drugs into oral fluid. The objective of this research was to provide data on the presence and concentrations of heroin, cocaine and multiple metabolites in oral fluid after illicit opioid and cocaine use. Thrice weekly oral fluid specimens (N=403) from 16 pregnant opiate-dependent women were obtained with the SalivetteRG oral fluid collection device. Evidence of heroin (N=62) and cocaine (N=130) use was detected in oral fluid by LC-APCI-MS/MS. 6-Acetylmorphine (6-AM), heroin and morphine were the major opiates detected, with median concentrations of 5.2, 2.3, and 7.5 ug/L, respectively. Cocaine and benzoylecgonine (BE) had median concentrations of 6.4 and 3.4 ug/L. Application of the Substance Abuse Mental Health Services Administration (SAMHSA) recommended cutoffs for morphine and codeine (40 ug/L), 6-AM (4 ug/L) and cocaine and BE (8 ug/L), yielded 28 opiate- and 50 cocaine-positive specimens. Oral fluid is a promising alternative matrix to monitor opiate and cocaine use in drug testing programs. These data guide interpretation of oral fluid test results and evaluate currently proposed SAMHSA oral fluid testing cutoffs. [Copyright 2006 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Dams, Riet AU - Choo, Robin E AU - Lambert, Willy E AU - Jones, Hendree AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, National Institute on Drug Abuse, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA email: mhuestis@intra.nida.nih.gov Y1 - 2007/03/16/ PY - 2007 DA - 2007 Mar 16 SP - 258 EP - 267 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 87 IS - 2-3 SN - 0376-8716, 0376-8716 KW - Oral fluid KW - Cocaine KW - Opiates KW - SAMHSA KW - Recovery KW - LC-MS KW - Screening KW - Pregnant women KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57077835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Oral+fluid+as+an+alternative+matrix+to+monitor+opiate+and+cocaine+use+in+substance-abuse+treatment+patients&rft.au=Dams%2C+Riet%3BChoo%2C+Robin+E%3BLambert%2C+Willy+E%3BJones%2C+Hendree%3BHuestis%2C+Marilyn+A&rft.aulast=Dams&rft.aufirst=Riet&rft.date=2007-03-16&rft.volume=87&rft.issue=2-3&rft.spage=258&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2006.08.020 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-12-10 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Opiates; Cocaine; Screening; Pregnant women DO - http://dx.doi.org/10.1016/j.drugalcdep.2006.08.020 ER - TY - JOUR T1 - Inhibitor of growth 4 suppresses cell spreading and cell migration by interacting with a novel binding partner, liprin alpha1. AN - 70281372; 17363573 AB - Inhibitor of growth 4 (ING4) is a candidate tumor suppressor that plays a major role in gene regulation, cell cycle control, apoptosis, and angiogenesis. ING4 expression is down-regulated in glioblastoma cells and head and neck squamous cell carcinoma. Here, we identified liprin alpha1/PPFIA1, a cytoplasmic protein necessary for focal adhesion formation and axon guidance, as a novel interacting protein with ING4. ING4 and liprin alpha1 colocalized at lamellipodia in the vicinity of vinculin. Overexpressed ING4 suppressed cell spreading and cell migration. In contrast, overexpressed liprin alpha1 enhanced cell spreading and cell migration. Knockdown of endogenous ING4 with RNA interference induced cell motility, whereas knockdown of endogenous liprin alpha1 suppressed cell motility. ING4 also suppressed cell motility that was enhanced by liprin alpha1. However, ING4 did not further suppress cell motility when liprin alpha1 was suppressed with RNA interference, suggesting a functional and mechanistic interdependence between these proteins. In addition to its nuclear functions, cytoplasmic ING4 interacts with liprin alpha1 to regulate cell migration and, with its known antiangiogenic function, may prevent invasion and metastasis. JF - Cancer research AU - Shen, Jiang-Cheng AU - Unoki, Motoko AU - Ythier, Damien AU - Duperray, Alain AU - Varticovski, Lyuba AU - Kumamoto, Kensuke AU - Pedeux, Remy AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4258, USA. Y1 - 2007/03/15/ PY - 2007 DA - 2007 Mar 15 SP - 2552 EP - 2558 VL - 67 IS - 6 SN - 0008-5472, 0008-5472 KW - Adaptor Proteins, Signal Transducing KW - 0 KW - Cell Cycle Proteins KW - Homeodomain Proteins KW - ING4 protein, human KW - PPFIA1 protein, human KW - RNA, Small Interfering KW - Tumor Suppressor Proteins KW - Index Medicus KW - Glioma -- pathology KW - Colonic Neoplasms -- genetics KW - Transfection KW - Humans KW - RNA, Small Interfering -- genetics KW - Colonic Neoplasms -- metabolism KW - Cell Line, Tumor KW - Cell Membrane -- metabolism KW - Glioma -- metabolism KW - Colonic Neoplasms -- pathology KW - Protein Binding KW - Glioma -- genetics KW - Tumor Suppressor Proteins -- biosynthesis KW - Adaptor Proteins, Signal Transducing -- metabolism KW - Homeodomain Proteins -- biosynthesis KW - Homeodomain Proteins -- genetics KW - Cell Cycle Proteins -- genetics KW - Cell Cycle Proteins -- biosynthesis KW - Cell Movement -- physiology KW - Tumor Suppressor Proteins -- metabolism KW - Tumor Suppressor Proteins -- genetics KW - Homeodomain Proteins -- metabolism KW - Adaptor Proteins, Signal Transducing -- genetics KW - Adaptor Proteins, Signal Transducing -- biosynthesis KW - Cell Cycle Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70281372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Inhibitor+of+growth+4+suppresses+cell+spreading+and+cell+migration+by+interacting+with+a+novel+binding+partner%2C+liprin+alpha1.&rft.au=Shen%2C+Jiang-Cheng%3BUnoki%2C+Motoko%3BYthier%2C+Damien%3BDuperray%2C+Alain%3BVarticovski%2C+Lyuba%3BKumamoto%2C+Kensuke%3BPedeux%2C+Remy%3BHarris%2C+Curtis+C&rft.aulast=Shen&rft.aufirst=Jiang-Cheng&rft.date=2007-03-15&rft.volume=67&rft.issue=6&rft.spage=2552&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-19 N1 - Date created - 2007-03-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell. 2000 Jan 7;100(1):57-70 [10647931] Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9671-6 [11481424] J Cell Sci. 2002 Apr 1;115(Pt 7):1497-510 [11896197] Oncogene. 2003 Jan 23;22(3):343-50 [12545155] Cancer Res. 2003 May 15;63(10):2373-8 [12750254] Science. 2003 Dec 5;302(5651):1704-9 [14657486] Nature. 2004 Mar 18;428(6980):328-32 [15029197] EMBO J. 1995 Jun 15;14(12):2827-38 [7796809] Nat Genet. 1996 Dec;14(4):415-20 [8944021] Dev Biol. 1997 Aug 1;188(1):134-46 [9245518] Science. 1998 Jun 5;280(5369):1614-7 [9616126] Cytogenet Cell Genet. 1998;83(3-4):232-5 [10072587] Cell Mol Life Sci. 2004 Oct;61(19-20):2597-613 [15526165] Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16251-6 [15528276] Mol Biol Evol. 2005 Jan;22(1):104-16 [15356280] Nat Neurosci. 2005 Apr;8(4):458-67 [15750591] Curr Biol. 2005 Apr 12;15(7):684-9 [15823543] Proc Natl Acad Sci U S A. 2005 May 24;102(21):7481-6 [15897452] Mol Cell Biol. 2005 Aug;25(15):6639-48 [16024799] Gene. 2005 Aug 15;356:109-17 [15935570] J Cell Biochem. 2005 Dec 15;96(6):1127-36 [16167330] Mol Cell. 2006 Jan 6;21(1):51-64 [16387653] Exp Cell Res. 2006 Apr 15;312(7):951-61 [16516887] Nature. 2006 Jul 6;442(7098):96-9 [16728974] Nature. 2006 Jul 6;442(7098):100-3 [16728977] J Biol Chem. 2006 Nov 10;281(45):34677-86 [16973615] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Structure and mechanism of kainate receptor modulation by anions. AN - 70273741; 17359918 AB - L-glutamate, the major excitatory neurotransmitter in the human brain, activates a family of ligand-gated ion channels, the major subtypes of which are named AMPA, kainate, and NMDA receptors. In common with many signal transduction proteins, glutamate receptors are modulated by ions and small molecules, including Ca(2+), Mg(2+), Zn(2+), protons, polyamines, and steroids. Strikingly, the activation of kainate receptors by glutamate requires the presence of both Na(+) and Cl(-) in the extracellular solution, and in the absence of these ions, receptor activity is abolished. Here, we identify the site and mechanism of action of anions. Surprisingly, we find that Cl(-) ions are essential structural components of kainate receptors. Cl(-) ions bind in a cavity formed at the interface between subunits in a dimer pair. In the absence of Cl(-), dimer stability is reduced, the rate of desensitization increases, and the fraction of receptors competent for activation by glutamate drops precipitously. JF - Neuron AU - Plested, Andrew J R AU - Mayer, Mark L AD - Laboratory of Cellular and Molecular Neurophysiology, Porter Neuroscience Research Center, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2007/03/15/ PY - 2007 DA - 2007 Mar 15 SP - 829 EP - 841 VL - 53 IS - 6 SN - 0896-6273, 0896-6273 KW - Anions KW - 0 KW - Receptors, Kainic Acid KW - Glutamic Acid KW - 3KX376GY7L KW - Index Medicus KW - Drug Interactions KW - Membrane Potentials -- radiation effects KW - Models, Molecular KW - Crystallography -- methods KW - Humans KW - Mutagenesis -- physiology KW - Glutamic Acid -- pharmacology KW - Structure-Activity Relationship KW - Transfection -- methods KW - Patch-Clamp Techniques KW - Binding Sites -- drug effects KW - Membrane Potentials -- drug effects KW - Cell Line, Transformed KW - Receptors, Kainic Acid -- chemistry KW - Receptors, Kainic Acid -- drug effects KW - Anions -- pharmacology KW - Protein Conformation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70273741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuron&rft.atitle=Structure+and+mechanism+of+kainate+receptor+modulation+by+anions.&rft.au=Plested%2C+Andrew+J+R%3BMayer%2C+Mark+L&rft.aulast=Plested&rft.aufirst=Andrew+J&rft.date=2007-03-15&rft.volume=53&rft.issue=6&rft.spage=829&rft.isbn=&rft.btitle=&rft.title=Neuron&rft.issn=08966273&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-15 N1 - Date created - 2007-03-15 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 2OJT; PDB; 2F34; 2F36 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dominant-negative activator protein 1 (TAM67) targets cyclooxygenase-2 and osteopontin under conditions in which it specifically inhibits tumorigenesis. AN - 70268300; 17363560 AB - Activation of activator protein 1 (AP-1) and nuclear factor kappaB (NFkappaB)-dependent transcription is required for tumor promotion in cell culture models and transgenic mice. Dominant-negative c-Jun (TAM67) blocks AP-1 activation by dimerizing with Jun or Fos family proteins and blocks NFkappaB activation by interacting with NFkappaB p65. Two-stage [7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)] skin carcinogenesis experiments in a model relevant to human cancer risk, transgenic mice expressing human papillomavirus 16 E7 oncogene (K14-HPV16-E7), show E7-enhanced tumor promotion. A cross to K14-TAM67-expressing mice results in dramatic inhibition of tumor promoter-induced AP-1 luciferase reporter activation and papillomagenesis. Epithelial specific TAM67 expression inhibits tumorigenesis without affecting TPA- or E7-induced hyperproliferation of the skin. Thus, the mouse model enriches for TAM67 targets relevant to tumorigenesis rather than to general cell proliferation or hyperplasia, implicating a subset of AP-1- and/or NFkappaB-dependent genes. The aim of the present study was to identify target genes responsible for TAM67 inhibition of DMBA-TPA-induced tumorigenesis. Microarray expression analysis of epidermal tissues revealed small sets of genes in which expression is both up-regulated by tumor promoter and down-regulated by TAM67. Among these, cyclooxygenase-2 (Cox-2/Ptgs2) and osteopontin (Opn/Spp1) are known to be functionally significant in driving carcinogenesis. Results identify both Cox-2 and Opn as transcriptional targets of TAM67 with CRE, but not NFkappaB sites important in the Cox-2 promoter and an AP-1 site important in the Opn promoter. JF - Cancer research AU - Matthews, Connie P AU - Birkholz, Alysia M AU - Baker, Alyson R AU - Perella, Christine M AU - Beck, George R AU - Young, Matthew R AU - Colburn, Nancy H AD - Laboratory of Cancer Prevention, National Cancer Institute, Frederick, Maryland 21702, USA. cmatthews@mail.ncifcrf.gov Y1 - 2007/03/15/ PY - 2007 DA - 2007 Mar 15 SP - 2430 EP - 2438 VL - 67 IS - 6 SN - 0008-5472, 0008-5472 KW - CCAAT-Enhancer-Binding Proteins KW - 0 KW - Cyclic AMP Response Element-Binding Protein KW - NF-kappa B KW - Oncogene Proteins, Viral KW - Papillomavirus E7 Proteins KW - Peptide Fragments KW - Proto-Oncogene Proteins c-jun KW - TAM67 peptide KW - Transcription Factor AP-1 KW - oncogene protein E7, Human papillomavirus type 16 KW - Osteopontin KW - 106441-73-0 KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Animals KW - Humans KW - Transcription, Genetic KW - Mice KW - Mice, Transgenic KW - NF-kappa B -- genetics KW - Promoter Regions, Genetic KW - Cyclic AMP Response Element-Binding Protein -- metabolism KW - Transfection KW - Cyclic AMP Response Element-Binding Protein -- genetics KW - CCAAT-Enhancer-Binding Proteins -- metabolism KW - Oncogene Proteins, Viral -- genetics KW - CCAAT-Enhancer-Binding Proteins -- genetics KW - NF-kappa B -- metabolism KW - Peptide Fragments -- genetics KW - Cyclooxygenase 2 -- genetics KW - Cyclooxygenase 2 -- biosynthesis KW - Osteopontin -- genetics KW - Proto-Oncogene Proteins c-jun -- biosynthesis KW - Transcription Factor AP-1 -- genetics KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Skin Neoplasms -- genetics KW - Osteopontin -- biosynthesis KW - Peptide Fragments -- biosynthesis KW - Skin Neoplasms -- chemically induced KW - Proto-Oncogene Proteins c-jun -- genetics KW - Gene Expression Regulation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70268300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Dominant-negative+activator+protein+1+%28TAM67%29+targets+cyclooxygenase-2+and+osteopontin+under+conditions+in+which+it+specifically+inhibits+tumorigenesis.&rft.au=Matthews%2C+Connie+P%3BBirkholz%2C+Alysia+M%3BBaker%2C+Alyson+R%3BPerella%2C+Christine+M%3BBeck%2C+George+R%3BYoung%2C+Matthew+R%3BColburn%2C+Nancy+H&rft.aulast=Matthews&rft.aufirst=Connie&rft.date=2007-03-15&rft.volume=67&rft.issue=6&rft.spage=2430&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-19 N1 - Date created - 2007-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sea anemone venom as a source of insecticidal peptides acting on voltage-gated Na+ channels. AN - 70251760; 17224168 AB - Sea anemones produce a myriad of toxic peptides and proteins of which a large group acts on voltage-gated Na+ channels. However, in comparison to other organisms, their venoms and toxins are poorly studied. Most of the known voltage-gated Na+ channel toxins isolated from sea anemone venoms act on neurotoxin receptor site 3 and inhibit the inactivation of these channels. Furthermore, it seems that most of these toxins have a distinct preference for crustaceans. Given the close evolutionary relationship between crustaceans and insects, it is not surprising that sea anemone toxins also profoundly affect insect voltage-gated Na+ channels, which constitutes the scope of this review. For this reason, these peptides can be considered as insecticidal lead compounds in the development of insecticides. JF - Toxicon : official journal of the International Society on Toxinology AU - Bosmans, Frank AU - Tytgat, Jan AD - Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, Building 35, 3B 211, NINDS, NIH, Bethesda, MD 20892, USA. Y1 - 2007/03/15/ PY - 2007 DA - 2007 Mar 15 SP - 550 EP - 560 VL - 49 IS - 4 SN - 0041-0101, 0041-0101 KW - Cnidarian Venoms KW - 0 KW - Insecticides KW - Peptides KW - Sodium Channel Blockers KW - Sodium Channels KW - Index Medicus KW - Ion Channel Gating KW - Animals KW - Sequence Alignment KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Species Specificity KW - Sea Anemones -- physiology KW - Sodium Channel Blockers -- pharmacology KW - Insecticides -- chemistry KW - Peptides -- chemistry KW - Pest Control, Biological KW - Peptides -- pharmacology KW - Sodium Channels -- drug effects KW - Insecticides -- pharmacology KW - Cnidarian Venoms -- pharmacology KW - Cnidarian Venoms -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70251760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.atitle=Sea+anemone+venom+as+a+source+of+insecticidal+peptides+acting+on+voltage-gated+Na%2B+channels.&rft.au=Bosmans%2C+Frank%3BTytgat%2C+Jan&rft.aulast=Bosmans&rft.aufirst=Frank&rft.date=2007-03-15&rft.volume=49&rft.issue=4&rft.spage=550&rft.isbn=&rft.btitle=&rft.title=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.issn=00410101&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-03 N1 - Date created - 2007-03-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharmacol Exp Ther. 2002 Dec;303(3):1067-74 [12438529] FEBS Lett. 2002 Dec 4;532(1-2):131-4 [12459477] Cell Signal. 2003 Feb;15(2):151-9 [12464386] FEBS Lett. 2003 Feb 27;537(1-3):106-10 [12606040] Genome Biol. 2003;4(3):207 [12620097] Science. 2003 Mar 21;299(5614):1887-9 [12649480] Toxicon. 2003 Apr;41(5):637-9 [12676443] Insect Biochem Mol Biol. 2003 Jun;33(6):563-77 [12770575] Toxicon. 1968 May;5(4):253-9 [4387960] FEBS Lett. 1975 Feb 15;50(3):311-4 [234860] Thromb Haemost. 1978 Apr 30;39(2):552-4 [581008] J Biol Chem. 1981 Jun 10;256(11):5764-9 [6113239] Biochemistry. 1981 Sep 1;20(18):5245-52 [6117312] J Physiol (Paris). 1984;79(4):309-17 [6152295] Eur J Biochem. 1985 Jul 1;150(1):171-3 [2862037] Biochemistry. 1985 Jul 2;24(14):3554-61 [2412579] Biochem Biophys Res Commun. 1985 Sep 30;131(3):1226-33 [2413857] FEBS Lett. 1988 Nov 7;239(2):266-70 [3181430] Proteins. 1989;6(4):357-71 [2576133] Toxicon. 1991;29(9):1051-84 [1686683] FEBS Lett. 1993 Jan 4;315(2):125-8 [8380269] Toxicon. 1992 Nov;30(11):1365-81 [1336629] Arch Insect Biochem Physiol. 1993;22(3-4):315-44 [8467099] J Biol Chem. 1993 Nov 25;268(33):24707-19 [7901218] J Biol Chem. 1994 Jan 7;269(1):254-9 [8276803] J Biol Chem. 1994 Jun 17;269(24):16785-8 [7911468] Biochim Biophys Acta. 1994 Jun 22;1192(2):197-204 [7912550] Biochemistry. 1994 Sep 20;33(37):11051-61 [7727358] Cell. 1995 Sep 22;82(6):1001-11 [7553842] Structure. 1995 Aug 15;3(8):791-803 [7582896] J Biol Chem. 1996 Apr 19;271(16):9422-8 [8621610] J Biol Chem. 1996 Apr 5;271(14):8034-45 [8626486] J Biol Chem. 1996 Jul 5;271(27):15950-62 [8663157] J Biol Chem. 1996 Sep 27;271(39):23828-35 [8798612] Toxicon. 1997 Apr;35(4):537-44 [9133708] J Gen Physiol. 1997 Aug;110(2):119-33 [9236205] Insect Biochem Mol Biol. 1997 Jun;27(6):523-8 [9304794] Pflugers Arch. 1997 Nov;434(6):742-9 [9306007] J Biol Chem. 1998 Jan 2;273(1):80-4 [9417050] Arch Toxicol. 2006 Jul;80(7):436-41 [16474963] Transgenic Res. 2006 Jun;15(3):349-57 [16779650] Biochemistry. 2006 Jul 25;45(29):8864-73 [16846229] Toxicon. 2006 Aug;48(2):211-20 [16814340] Cell Biochem Biophys. 2003;38(2):215-38 [12777715] Mol Pharmacol. 2003 Jul;64(1):59-69 [12815161] J Neurosci. 2003 Aug 20;23(20):7577-85 [12930796] Biochem Biophys Res Commun. 2004 Jan 2;313(1):163-70 [14672713] Mol Pharmacol. 2004 Mar;65(3):685-91 [14978247] Toxicon. 2004 Apr;43(5):587-99 [15066415] EMBO J. 2004 Apr 7;23(7):1516-25 [15044953] Biochemistry. 2004 Jun 8;43(22):7082-9 [15170345] J Biol Chem. 2004 Aug 6;279(32):33323-35 [15169781] Proc Biol Sci. 2000 May 22;267(1447):1011-9 [10874751] Biochimie. 2000 Sep-Oct;82(9-10):869-81 [11086217] Neuron. 2000 Nov;28(2):365-8 [11144347] Pest Manag Sci. 2001 Oct;57(10):981-7 [11695193] Br J Pharmacol. 2001 Nov;134(6):1195-206 [11704639] J Biol Chem. 1998 Mar 20;273(12):6744-9 [9506974] Nature. 1998 Apr 16;392(6677):667-8 [9565028] Annu Rev Entomol. 1999;44:429-55 [9990721] Eur J Biochem. 1999 Sep;264(2):287-300 [10491073] Toxicon. 2005 Jan;45(1):33-41 [15581681] Mol Pharmacol. 2005 Feb;67(2):513-22 [15525757] J Biol Chem. 2005 Feb 11;280(6):5045-53 [15569679] FEBS Lett. 2005 Jul 18;579(18):3881-4 [15990094] J Mol Biol. 2005 Nov 4;353(4):788-803 [16209876] Toxicon. 2006 Feb;47(2):182-7 [16330063] Mar Biotechnol (NY). 2006 Jan-Feb;8(1):1-10 [16372161] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Altered in-vitro and in-vivo expression of glial glutamate transporter-1 following exposure to cerebrospinal fluid of amyotrophic lateral sclerosis patients. AN - 70240158; 17254611 AB - Our earlier studies have shown that cerebrospinal fluid (CSF) of amyotrophic lateral sclerosis (ALS) patients causes death of motor neurons, both in in-vitro as well as in-vivo. There was an aberrant phosphorylation of neurofilaments in cultured spinal cord neurons of chick and rats following exposure to CSF of ALS patients (ALS-CSF). Other features of neurodegeneration, such as swollen neuronal soma and beading of neurites were also observed. In neonatal rat pups exposed to ALS-CSF, we observed phosphorylated neurofilaments in the soma of spinal motor neurons in addition to the increased lactate dehydrogenase activity and reactive astrogliosis. The present study examines the effect of ALS-CSF on the expression of glial glutamate transporter (GLT-1) in embryonic rat spinal cord cultures as well as in spinal astrocytes of neonatal rats. Immunostaining suggested a decrease in the expression of GLT-1 by astrocytes both in culture and in-vivo following exposure to ALS-CSF. Quantification of Western blots confirmed the decreased expression of GLT-1. Our results provide evidence that toxic factor(s) present in ALS-CSF depletes GLT-1 expression. This could lead to an increased level of glutamate in the synaptic pool causing excitotoxicity to motor neurons, possibly by triggering the 'glutamate-mediated toxicity-pathway'. JF - Journal of the neurological sciences AU - Shobha, K AU - Vijayalakshmi, K AU - Alladi, Phalguni Anand AU - Nalini, A AU - Sathyaprabha, T N AU - Raju, T R AD - Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Hosur Road, Bangalore-560 029, India. Y1 - 2007/03/15/ PY - 2007 DA - 2007 Mar 15 SP - 9 EP - 16 VL - 254 IS - 1-2 SN - 0022-510X, 0022-510X KW - Biological Factors KW - 0 KW - Enzyme Inhibitors KW - Excitatory Amino Acid Transporter 2 KW - Neurotoxins KW - Glutamic Acid KW - 3KX376GY7L KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - NG-Nitroarginine Methyl Ester KW - V55S2QJN2X KW - Index Medicus KW - Animals KW - Cell Death -- physiology KW - NG-Nitroarginine Methyl Ester -- pharmacology KW - Glutamic Acid -- metabolism KW - Humans KW - L-Lactate Dehydrogenase -- drug effects KW - Neurotoxins -- cerebrospinal fluid KW - Cell Death -- drug effects KW - Presynaptic Terminals -- metabolism KW - Rats KW - Animals, Newborn KW - Cells, Cultured KW - Injections, Spinal KW - Up-Regulation -- drug effects KW - Enzyme Inhibitors -- pharmacology KW - Middle Aged KW - Immunohistochemistry KW - Male KW - L-Lactate Dehydrogenase -- metabolism KW - Female KW - Excitatory Amino Acid Transporter 2 -- metabolism KW - Spinal Cord -- physiopathology KW - Cerebrospinal Fluid KW - Biological Factors -- cerebrospinal fluid KW - Amyotrophic Lateral Sclerosis -- cerebrospinal fluid KW - Astrocytes -- drug effects KW - Spinal Cord -- drug effects KW - Biological Factors -- toxicity KW - Excitatory Amino Acid Transporter 2 -- drug effects KW - Astrocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70240158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+neurological+sciences&rft.atitle=Altered+in-vitro+and+in-vivo+expression+of+glial+glutamate+transporter-1+following+exposure+to+cerebrospinal+fluid+of+amyotrophic+lateral+sclerosis+patients.&rft.au=Shobha%2C+K%3BVijayalakshmi%2C+K%3BAlladi%2C+Phalguni+Anand%3BNalini%2C+A%3BSathyaprabha%2C+T+N%3BRaju%2C+T+R&rft.aulast=Shobha&rft.aufirst=K&rft.date=2007-03-15&rft.volume=254&rft.issue=1-2&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+neurological+sciences&rft.issn=0022510X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-29 N1 - Date created - 2007-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Multiple residues in the second extracellular loop are critical for M3 muscarinic acetylcholine receptor activation. AN - 70226178; 17213190 AB - Recent studies suggest that the second extracellular loop (o2 loop) of bovine rhodopsin and other class I G protein-coupled receptors (GPCRs) targeted by biogenic amine ligands folds deeply into the transmembrane receptor core where the binding of cis-retinal and biogenic amine ligands is known to occur. In the past, the potential role of the o2 loop in agonist-dependent activation of biogenic amine GPCRs has not been studied systematically. To address this issue, we used the M(3) muscarinic acetylcholine receptor (M3R), a prototypic class I GPCR, as a model system. Specifically, we subjected the o2 loop of the M3R to random mutagenesis and subsequently applied a novel yeast genetic screen to identity single amino acid substitutions that interfered with M3R function. This screen led to the recovery of about 20 mutant M3Rs containing single amino acid changes in the o2 loop that were inactive in yeast. In contrast, application of the same strategy to the extracellular N-terminal domain of the M3R did not yield any single point mutations that disrupted M3R function. Pharmacological characterization of many of the recovered mutant M3Rs in mammalian cells, complemented by site-directed mutagenesis studies, indicated that the presence of several o2 loop residues is important for efficient agonist-induced M3R activation. Besides the highly conserved Cys(220) residue, Gln(207), Gly(211), Arg(213), Gly(218), Ile(222), Phe(224), Leu(225), and Pro(228) were found to be of particular functional importance. In general, mutational modification of these residues had little effect on agonist binding affinities. Our findings are therefore consistent with a model in which multiple o2 loop residues are involved in stabilizing the active state of the M3R. Given the high degree of structural homology found among all biogenic amine GPCRs, our findings should be of considerable general relevance. JF - The Journal of biological chemistry AU - Scarselli, Marco AU - Li, Bo AU - Kim, Soo-Kyung AU - Wess, Jürgen AD - Molecular Signaling , Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2007/03/09/ PY - 2007 DA - 2007 Mar 09 SP - 7385 EP - 7396 VL - 282 IS - 10 SN - 0021-9258, 0021-9258 KW - Receptor, Muscarinic M3 KW - 0 KW - Index Medicus KW - Saccharomyces cerevisiae -- genetics KW - Animals KW - COS Cells KW - Models, Molecular KW - Cercopithecus aethiops KW - Point Mutation KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Amino Acid Substitution KW - Structure-Activity Relationship KW - Receptor, Muscarinic M3 -- chemistry KW - Receptor, Muscarinic M3 -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70226178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Multiple+residues+in+the+second+extracellular+loop+are+critical+for+M3+muscarinic+acetylcholine+receptor+activation.&rft.au=Scarselli%2C+Marco%3BLi%2C+Bo%3BKim%2C+Soo-Kyung%3BWess%2C+J%C3%BCrgen&rft.aulast=Scarselli&rft.aufirst=Marco&rft.date=2007-03-09&rft.volume=282&rft.issue=10&rft.spage=7385&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-13 N1 - Date created - 2007-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Rapid Evolution of the Mu2 Gene T2 - 48th Annual Drosophila Research Conference AN - 40576259; 4537621 JF - 48th Annual Drosophila Research Conference AU - Mason, James AU - Dronamraju, Raghuvar Y1 - 2007/03/07/ PY - 2007 DA - 2007 Mar 07 KW - Evolutionary genetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40576259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Drosophila+Research+Conference&rft.atitle=Rapid+Evolution+of+the+Mu2+Gene&rft.au=Mason%2C+James%3BDronamraju%2C+Raghuvar&rft.aulast=Mason&rft.aufirst=James&rft.date=2007-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/genetics/gsa/dros/dros2007/absvolume.sh tml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Plasma Membrane Diffusion Barriers in the Precellularizing Drosophila Embryo T2 - 48th Annual Drosophila Research Conference AN - 40573802; 4537181 JF - 48th Annual Drosophila Research Conference AU - Mavrakis, Manos AU - Rikhy, Richa AU - Phair, Bob AU - Lippincott-Schwartz, Jennifer Y1 - 2007/03/07/ PY - 2007 DA - 2007 Mar 07 KW - Embryos KW - Plasma membranes KW - Diffusion KW - Barriers KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40573802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Drosophila+Research+Conference&rft.atitle=Plasma+Membrane+Diffusion+Barriers+in+the+Precellularizing+Drosophila+Embryo&rft.au=Mavrakis%2C+Manos%3BRikhy%2C+Richa%3BPhair%2C+Bob%3BLippincott-Schwartz%2C+Jennifer&rft.aulast=Mavrakis&rft.aufirst=Manos&rft.date=2007-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/genetics/gsa/dros/dros2007/absvolume.sh tml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dissection of a Neuronal Network Required for Wing Expansion and Tanning using the Split Gal4 System T2 - 48th Annual Drosophila Research Conference AN - 40572928; 4537569 JF - 48th Annual Drosophila Research Conference AU - Luan, Haojiang AU - Diao, Fengqiu AU - Wan, Kevin Ho AU - Peabody, Nathan AU - White, Benjamin Y1 - 2007/03/07/ PY - 2007 DA - 2007 Mar 07 KW - Wings KW - Tanning KW - Neural networks KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40572928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Drosophila+Research+Conference&rft.atitle=Dissection+of+a+Neuronal+Network+Required+for+Wing+Expansion+and+Tanning+using+the+Split+Gal4+System&rft.au=Luan%2C+Haojiang%3BDiao%2C+Fengqiu%3BWan%2C+Kevin+Ho%3BPeabody%2C+Nathan%3BWhite%2C+Benjamin&rft.aulast=Luan&rft.aufirst=Haojiang&rft.date=2007-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/genetics/gsa/dros/dros2007/absvolume.sh tml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Notch Endosomal Routing and g-Secretase Function in Various Neurogenic Backgrounds T2 - 48th Annual Drosophila Research Conference AN - 40572805; 4537534 JF - 48th Annual Drosophila Research Conference AU - Kanwar, Ritu AU - Fortini, Mark Y1 - 2007/03/07/ PY - 2007 DA - 2007 Mar 07 KW - Notch protein KW - Secretase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40572805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Drosophila+Research+Conference&rft.atitle=Regulation+of+Notch+Endosomal+Routing+and+g-Secretase+Function+in+Various+Neurogenic+Backgrounds&rft.au=Kanwar%2C+Ritu%3BFortini%2C+Mark&rft.aulast=Kanwar&rft.aufirst=Ritu&rft.date=2007-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/genetics/gsa/dros/dros2007/absvolume.sh tml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transcriptional Regulation of Nerfin-1 Expression during Drosophila Neurogenesis T2 - 48th Annual Drosophila Research Conference AN - 40572076; 4537295 JF - 48th Annual Drosophila Research Conference AU - Kuzin, Alexander AU - Kundu, Mukta AU - Brody, Thomas AU - Odenwald, Ward F Y1 - 2007/03/07/ PY - 2007 DA - 2007 Mar 07 KW - Transcription KW - Neurogenesis KW - Gene regulation KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40572076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Drosophila+Research+Conference&rft.atitle=Transcriptional+Regulation+of+Nerfin-1+Expression+during+Drosophila+Neurogenesis&rft.au=Kuzin%2C+Alexander%3BKundu%2C+Mukta%3BBrody%2C+Thomas%3BOdenwald%2C+Ward+F&rft.aulast=Kuzin&rft.aufirst=Alexander&rft.date=2007-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/genetics/gsa/dros/dros2007/absvolume.sh tml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - O-Linked Glycan Expression during Drosophila Development T2 - 48th Annual Drosophila Research Conference AN - 40570170; 4537443 JF - 48th Annual Drosophila Research Conference AU - Tian, E AU - Hagen, Kelly Ten Y1 - 2007/03/07/ PY - 2007 DA - 2007 Mar 07 KW - Polysaccharides KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40570170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Drosophila+Research+Conference&rft.atitle=O-Linked+Glycan+Expression+during+Drosophila+Development&rft.au=Tian%2C+E%3BHagen%2C+Kelly+Ten&rft.aulast=Tian&rft.aufirst=E&rft.date=2007-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/genetics/gsa/dros/dros2007/absvolume.sh tml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Missing Oocyte and Nup44A/Seh-1 Physically Interact in the Drosophila Germ Line T2 - 48th Annual Drosophila Research Conference AN - 40568655; 4537465 JF - 48th Annual Drosophila Research Conference AU - Senger, Stefania AU - Lilly, Mary Y1 - 2007/03/07/ PY - 2007 DA - 2007 Mar 07 KW - Oocytes KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40568655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Drosophila+Research+Conference&rft.atitle=Missing+Oocyte+and+Nup44A%2FSeh-1+Physically+Interact+in+the+Drosophila+Germ+Line&rft.au=Senger%2C+Stefania%3BLilly%2C+Mary&rft.aulast=Senger&rft.aufirst=Stefania&rft.date=2007-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/genetics/gsa/dros/dros2007/absvolume.sh tml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Tis11 in Drosophila Melanogaster T2 - 48th Annual Drosophila Research Conference AN - 40568346; 4537347 JF - 48th Annual Drosophila Research Conference AU - Fedic, Robert AU - Blackshear, Perry J AU - Kirchner, Jasmin AU - Mason, James M Y1 - 2007/03/07/ PY - 2007 DA - 2007 Mar 07 KW - Gene expression KW - Drosophila melanogaster KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40568346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Drosophila+Research+Conference&rft.atitle=Role+of+Tis11+in+Drosophila+Melanogaster&rft.au=Fedic%2C+Robert%3BBlackshear%2C+Perry+J%3BKirchner%2C+Jasmin%3BMason%2C+James+M&rft.aulast=Fedic&rft.aufirst=Robert&rft.date=2007-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/genetics/gsa/dros/dros2007/absvolume.sh tml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mapping Fly Color-Vision Circuits T2 - 48th Annual Drosophila Research Conference AN - 40567702; 4537579 JF - 48th Annual Drosophila Research Conference AU - Gao, Shuying AU - Ting, Chun-Yuan AU - Huang, Songling AU - Meinertzhagen, Ian A AU - Lee, Chi-Hon Y1 - 2007/03/07/ PY - 2007 DA - 2007 Mar 07 KW - Mapping KW - Circuits KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40567702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Drosophila+Research+Conference&rft.atitle=Mapping+Fly+Color-Vision+Circuits&rft.au=Gao%2C+Shuying%3BTing%2C+Chun-Yuan%3BHuang%2C+Songling%3BMeinertzhagen%2C+Ian+A%3BLee%2C+Chi-Hon&rft.aulast=Gao&rft.aufirst=Shuying&rft.date=2007-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/genetics/gsa/dros/dros2007/absvolume.sh tml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CisDECODER Reveals the Regulatory Logic Underlying Coordinate Gene Expression T2 - 48th Annual Drosophila Research Conference AN - 40567576; 4537971 JF - 48th Annual Drosophila Research Conference AU - Brody, Thomas AU - Rasband, Wayne AU - Baler, Kevin AU - Kuzin, Alexander AU - Kundu, Mukta AU - Ross, Jermaine AU - Odenwald, Ward Y1 - 2007/03/07/ PY - 2007 DA - 2007 Mar 07 KW - Gene expression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40567576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Drosophila+Research+Conference&rft.atitle=CisDECODER+Reveals+the+Regulatory+Logic+Underlying+Coordinate+Gene+Expression&rft.au=Brody%2C+Thomas%3BRasband%2C+Wayne%3BBaler%2C+Kevin%3BKuzin%2C+Alexander%3BKundu%2C+Mukta%3BRoss%2C+Jermaine%3BOdenwald%2C+Ward&rft.aulast=Brody&rft.aufirst=Thomas&rft.date=2007-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/genetics/gsa/dros/dros2007/absvolume.sh tml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mutator2: A Possible Chromatin Modulator at Telomeres T2 - 48th Annual Drosophila Research Conference AN - 40567440; 4537277 JF - 48th Annual Drosophila Research Conference AU - Prasad, Sudha AU - Mason, James M Y1 - 2007/03/07/ PY - 2007 DA - 2007 Mar 07 KW - Telomeres KW - Chromatin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40567440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Drosophila+Research+Conference&rft.atitle=Mutator2%3A+A+Possible+Chromatin+Modulator+at+Telomeres&rft.au=Prasad%2C+Sudha%3BMason%2C+James+M&rft.aulast=Prasad&rft.aufirst=Sudha&rft.date=2007-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/genetics/gsa/dros/dros2007/absvolume.sh tml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Targeted Activation of CCAP Neurons using the Cold-Sensitive TRPM8 Channel Reveals a Pre-eclosion Critical Period in Wing Expansion T2 - 48th Annual Drosophila Research Conference AN - 40567364; 4537563 JF - 48th Annual Drosophila Research Conference AU - Peabody, Nathan AU - Vreede, Andrew AU - Diao, Fengqiu AU - Dewey, Elizabeth AU - Honegger, Hans-Willi AU - White, Benjamin Y1 - 2007/03/07/ PY - 2007 DA - 2007 Mar 07 KW - Channels KW - Wings KW - Transient receptor potential proteins KW - Critical period KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40567364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Drosophila+Research+Conference&rft.atitle=Targeted+Activation+of+CCAP+Neurons+using+the+Cold-Sensitive+TRPM8+Channel+Reveals+a+Pre-eclosion+Critical+Period+in+Wing+Expansion&rft.au=Peabody%2C+Nathan%3BVreede%2C+Andrew%3BDiao%2C+Fengqiu%3BDewey%2C+Elizabeth%3BHonegger%2C+Hans-Willi%3BWhite%2C+Benjamin&rft.aulast=Peabody&rft.aufirst=Nathan&rft.date=2007-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/genetics/gsa/dros/dros2007/absvolume.sh tml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Studies on the Function of MU2 T2 - 48th Annual Drosophila Research Conference AN - 40567128; 4537274 JF - 48th Annual Drosophila Research Conference AU - Dronamraju, Raghuvar G AU - Mason, James M Y1 - 2007/03/07/ PY - 2007 DA - 2007 Mar 07 KW - Chromosomes KW - Genomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40567128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Drosophila+Research+Conference&rft.atitle=Studies+on+the+Function+of+MU2&rft.au=Dronamraju%2C+Raghuvar+G%3BMason%2C+James+M&rft.aulast=Dronamraju&rft.aufirst=Raghuvar&rft.date=2007-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/genetics/gsa/dros/dros2007/absvolume.sh tml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Small RNAs Associated with the GYPSY Chromatin Insulator T2 - 48th Annual Drosophila Research Conference AN - 40565943; 4537974 JF - 48th Annual Drosophila Research Conference AU - Lei, Elissa P Y1 - 2007/03/07/ PY - 2007 DA - 2007 Mar 07 KW - Chromatin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40565943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Drosophila+Research+Conference&rft.atitle=Identification+of+Small+RNAs+Associated+with+the+GYPSY+Chromatin+Insulator&rft.au=Lei%2C+Elissa+P&rft.aulast=Lei&rft.aufirst=Elissa&rft.date=2007-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/genetics/gsa/dros/dros2007/absvolume.sh tml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Deletion of the Drosophila Homologue of Mammalian Herp Decreases Fly Survival in Response to ER Stress T2 - 48th Annual Drosophila Research Conference AN - 40556266; 4537840 JF - 48th Annual Drosophila Research Conference AU - Tountas, Nikolaos A AU - Fortini, Mark E Y1 - 2007/03/07/ PY - 2007 DA - 2007 Mar 07 KW - Stress KW - Survival KW - Deletion KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Drosophila+Research+Conference&rft.atitle=Deletion+of+the+Drosophila+Homologue+of+Mammalian+Herp+Decreases+Fly+Survival+in+Response+to+ER+Stress&rft.au=Tountas%2C+Nikolaos+A%3BFortini%2C+Mark+E&rft.aulast=Tountas&rft.aufirst=Nikolaos&rft.date=2007-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/genetics/gsa/dros/dros2007/absvolume.sh tml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Dynamin Function in Cytoskeletal Remodelling during Drosophila Embryogenesis by Time-Lapse Imaging T2 - 48th Annual Drosophila Research Conference AN - 40556068; 4537881 JF - 48th Annual Drosophila Research Conference AU - Rikhy, Richa AU - Mavrakis, Manos AU - Lippincott-Schwartz, Jennifer Y1 - 2007/03/07/ PY - 2007 DA - 2007 Mar 07 KW - Cytoskeleton KW - Imaging techniques KW - Embryogenesis KW - Dynamin KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Drosophila+Research+Conference&rft.atitle=Analysis+of+Dynamin+Function+in+Cytoskeletal+Remodelling+during+Drosophila+Embryogenesis+by+Time-Lapse+Imaging&rft.au=Rikhy%2C+Richa%3BMavrakis%2C+Manos%3BLippincott-Schwartz%2C+Jennifer&rft.aulast=Rikhy&rft.aufirst=Richa&rft.date=2007-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/genetics/gsa/dros/dros2007/absvolume.sh tml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multiple microRNAs Act Cooperatively in the Developing Nervous System to Regulate the Temporal and Spatial Expression Dynamics of the Drosophila Nerfin-1 Protein T2 - 48th Annual Drosophila Research Conference AN - 40556029; 4537878 JF - 48th Annual Drosophila Research Conference AU - Kuzin, Alexander AU - Kundu, Mukta AU - Brody, Thomas AU - Odenwald, Ward F Y1 - 2007/03/07/ PY - 2007 DA - 2007 Mar 07 KW - MiRNA KW - Nervous system KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40556029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Drosophila+Research+Conference&rft.atitle=Multiple+microRNAs+Act+Cooperatively+in+the+Developing+Nervous+System+to+Regulate+the+Temporal+and+Spatial+Expression+Dynamics+of+the+Drosophila+Nerfin-1+Protein&rft.au=Kuzin%2C+Alexander%3BKundu%2C+Mukta%3BBrody%2C+Thomas%3BOdenwald%2C+Ward+F&rft.aulast=Kuzin&rft.aufirst=Alexander&rft.date=2007-03-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Drosophila+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.drosophila-conf.org/genetics/gsa/dros/dros2007/absvolume.sh tml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Longitudinal Measurement of Clinical Mammographic Breast Density to Improve Estimation of Breast Cancer Risk AN - 220988068; 17341730 AB - Background: Whether a change over time in clinically measured mammographic breast density influences breast cancer risk is unknown. Methods: From January 1993 to December 2003, data that included American College of Radiology Breast Imaging Reporting and Data System (BI-RADS) breast density categories (1-4 in order of increasing density) were collected prospectively on 301,955 women aged 30 and older who were not using postmenopausal hormone replacement therapy and underwent at least two screening mammography examinations; 2639 of the women were diagnosed with breast cancer within 1 year of the last examination. Women's first and last BI-RADS breast density (average 3.2 years apart) and logistic regression were used to model the odds of having invasive breast cancer or ductal carcinoma in situ diagnosed within 12 months of the last examination by change in BI-RADS category. Rates of breast cancer adjusted for age, mammography registry, and time between screening examinations were estimated from this model. All statistical tests were two-sided. Results: The rate (breast cancers per 1000 women) of breast cancer was higher if BI-RADS breast density category increased from 1 to 2 (5.6, 95% confidence interval [CI] = 4.7 to 6.9) or 1 to 3 (9.9, 95% CI = 6.4 to 15.5) compared to when it remained at BI-RADS density of 1 (3.0, 95% CI = 2.3 to 3.9; P<.001 for trend). Similar and statistically significant trends between increased or decreased density and increased or decreased risk of breast cancer, respectively, were observed for women whose breast density category was initially 2 or 3 and changed categories. BI-RADS density of 4 on the first examination was associated with a high rate of breast cancer (range 9.1-13.4) that remained high even if breast density decreased. Conclusion: An increase in BI-RADS breast density category within 3 years may be associated with an increase in breast cancer risk and a decrease in density category with a decrease in risk compared to breast cancer risk in women in whom breast density category remains unchanged. Two longitudinal measures of BI-RADS breast density may better predict a woman's risk of breast cancer than a single measure. [PUBLICATION ABSTRACT] JF - Journal of the National Cancer Institute AU - Kerlikowske, Karla AU - Ichikawa, Laura AU - Miglioretti, Diana L AU - Buist, Diana S M AU - Vacek, Pamela M AU - Smith-Bindman, Rebecca AU - Yankaskas, Bonnie AU - Carney, Patricia A AU - Ballard-Barbash, Rachel Y1 - 2007/03/07/ PY - 2007 DA - 2007 Mar 07 SP - 386 EP - 95 CY - Oxford PB - Oxford Publishing Limited(England) VL - 99 IS - 5 SN - 00278874 KW - Medical Sciences--Oncology KW - Breast cancer KW - Mammography KW - Measurement techniques KW - Risk factors KW - Medical imaging KW - Carcinoma, Ductal, Breast -- prevention & control KW - Odds Ratio KW - Carcinoma, Intraductal, Noninfiltrating -- diagnosis KW - Premenopause KW - Humans KW - SEER Program KW - Aged KW - Predictive Value of Tests KW - Carcinoma, Intraductal, Noninfiltrating -- prevention & control KW - Research Design KW - Risk Assessment KW - Prospective Studies KW - Postmenopause KW - Breast Neoplasms -- pathology KW - Logistic Models KW - Risk Factors KW - Adult KW - Carcinoma, Ductal, Breast -- diagnosis KW - Middle Aged KW - Time Factors KW - Female KW - Breast Neoplasms -- diagnosis KW - Breast Neoplasms -- prevention & control KW - Breast -- pathology KW - Mass Screening -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/220988068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Longitudinal+Measurement+of+Clinical+Mammographic+Breast+Density+to+Improve+Estimation+of+Breast+Cancer+Risk&rft.au=Kerlikowske%2C+Karla%3BIchikawa%2C+Laura%3BMiglioretti%2C+Diana+L%3BBuist%2C+Diana+S+M%3BVacek%2C+Pamela+M%3BSmith-Bindman%2C+Rebecca%3BYankaskas%2C+Bonnie%3BCarney%2C+Patricia+A%3BBallard-Barbash%2C+Rachel&rft.aulast=Kerlikowske&rft.aufirst=Karla&rft.date=2007-03-07&rft.volume=99&rft.issue=5&rft.spage=386&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjk066 LA - English DB - ProQuest Central N1 - Copyright - © The Author 2007. Published by Oxford University Press. N1 - Document feature - Tables; References N1 - Last updated - 2014-05-19 N1 - CODEN - JNCIEQ DO - http://dx.doi.org/10.1093/jnci/djk066 ER - TY - JOUR T1 - Synthetic Macrolides that Inhibit Breast Cancer Cell Migration in Vitro AN - 20372174; 7731506 AB - The design and synthesis of a series of natural product-like synthetic macrolides built upon a quinic acid-containing scaffold are described. Three of the macrolides (1, 3, and 6) have been shown to inhibit 4T1 breast cancer cell migration with low nanomolar to sub-micromolar IC sub(50) values (77, 525, and 550 nM, respectively) in complementary assays including a quantitative cell migration assay and a semiquantitative wound healing assay. JF - Journal of the American Chemical Society AU - Metaferia, B B AU - Chen, L AU - Baker, H L AU - Huang, X-Y AU - Bewley, CA AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA, caroleb@mail.nih.gov Y1 - 2007/03/07/ PY - 2007 DA - 2007 Mar 07 SP - 2434 EP - 2435 VL - 129 IS - 9 SN - 1272-7863, 1272-7863 KW - Biotechnology and Bioengineering Abstracts KW - Wound healing KW - Breast cancer KW - Cell migration KW - scaffolds KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20372174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Chemical+Society&rft.atitle=Synthetic+Macrolides+that+Inhibit+Breast+Cancer+Cell+Migration+in+Vitro&rft.au=Metaferia%2C+B+B%3BChen%2C+L%3BBaker%2C+H+L%3BHuang%2C+X-Y%3BBewley%2C+CA&rft.aulast=Metaferia&rft.aufirst=B&rft.date=2007-03-07&rft.volume=129&rft.issue=9&rft.spage=2434&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Chemical+Society&rft.issn=12727863&rft_id=info:doi/10.1021%2Fja068538d LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cell migration; Breast cancer; scaffolds; Wound healing DO - http://dx.doi.org/10.1021/ja068538d ER - TY - JOUR T1 - Asymmetry of syringomycin E channel studied by polymer partitioning AN - 19875307; 7481735 AB - To probe the size of the ion channel formed by Pseudomonas syringae lipodepsipeptide syringomycin E, we use the partial blockage of ion current by penetrating poly(ethylene glycol)s. Earlier experiments with symmetric application of these polymers yielded a radius estimate of arrow right nm. Now, motivated by the asymmetric non-ohmic current-voltage curves reported for this channel, we explore its structural asymmetry. We gauge this asymmetry by studying the channel conductance after one-sided addition of differently sized poly(ethylene glycol)s. We find that small polymers added to the cis-side of the membrane (the side of lipodepsipeptide addition) reduce channel conductance much less than do the same polymers added to the trans-side. We interpret our results to suggest that the water-filled pore of the channel is conical with cis- and trans-radii differing by a factor of 2-3 and that the smaller cis-radius is in the 0.25-0.35nm range. In symmetric, two-sided addition, polymers entering the pore from the larger opening dominate blockage. JF - FEBS Letters AU - Ostroumova, O S AU - Gurnev, P A AU - Schagina, LV AU - Bezrukov, S M AD - NIH, 9000 Rockville Pk., Bldg. 9, Rm. 1N-124B, Bethesda, MD 20892-0924, USA, bezrukos@mail.nih.gov Y1 - 2007/03/06/ PY - 2007 DA - 2007 Mar 06 SP - 804 EP - 808 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 581 IS - 5 SN - 0014-5793, 0014-5793 KW - Microbiology Abstracts B: Bacteriology KW - Conductance KW - Channel pores KW - Asymmetry KW - Ion channels KW - Probes KW - Ion currents KW - Pseudomonas syringae KW - lipodepsipeptides KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19875307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=Asymmetry+of+syringomycin+E+channel+studied+by+polymer+partitioning&rft.au=Ostroumova%2C+O+S%3BGurnev%2C+P+A%3BSchagina%2C+LV%3BBezrukov%2C+S+M&rft.aulast=Ostroumova&rft.aufirst=O&rft.date=2007-03-06&rft.volume=581&rft.issue=5&rft.spage=804&rft.isbn=&rft.btitle=&rft.title=FEBS+Letters&rft.issn=00145793&rft_id=info:doi/10.1016%2Fj.febslet.2007.01.063 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Channel pores; Conductance; Ion channels; Asymmetry; Probes; Ion currents; lipodepsipeptides; Pseudomonas syringae DO - http://dx.doi.org/10.1016/j.febslet.2007.01.063 ER - TY - JOUR T1 - Direct visualization of Escherichia coli chemotaxis receptor arrays using cryo-electron microscopy AN - 19615901; 7340309 AB - Signal transduction in bacterial chemotaxis is initiated by the binding of extracellular ligands to a specialized family of methyl-accepting chemoreceptor proteins. Chemoreceptors cluster at distinct regions of the cell and form stable ternary complexes with the histidine autokinase CheA and the adapter protein CheW. Here we report the direct visualization and spatial organization of chemoreceptor arrays in intact Escherichia coli cells by using cryo-electron tomography and biochemical techniques. In wild-type cells, ternary complexes are arranged as an extended lattice, which may or may not be ordered, with significant variations in the size and specific location among cells in the same population. In the absence of CheA and CheW, chemoreceptors do not form observable clusters and are diffusely localized to the cell pole. At disproportionately high receptor levels, membrane invaginations containing nonfunctional, axially interacting receptor assemblies are formed. However, functional chemoreceptor arrays can be reestablished by increasing cellular levels of CheA and CheW. Our results demonstrate that chemotaxis in E. coli requires the presence of chemoreceptor arrays and that the formation of these arrays requires the scaffolding interactions of the signaling molecules CheA and CheW. JF - Proceedings of the National Academy of Sciences, USA AU - Zhang, Peijun AU - Khursigara, Cezar M AU - Hartnell, Lisa M AU - Subramaniam, Sriram AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 Y1 - 2007/03/06/ PY - 2007 DA - 2007 Mar 06 SP - 3777 EP - 3781 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 10 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology; Chemoreception Abstracts KW - Chemoreceptors KW - adaptor proteins KW - CheW protein KW - Histidine KW - Escherichia coli KW - Tomography KW - Invaginations KW - CheA protein KW - Chemotaxis KW - Signal transduction KW - R 18003:Chemotaxis KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19615901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Direct+visualization+of+Escherichia+coli+chemotaxis+receptor+arrays+using+cryo-electron+microscopy&rft.au=Zhang%2C+Peijun%3BKhursigara%2C+Cezar+M%3BHartnell%2C+Lisa+M%3BSubramaniam%2C+Sriram&rft.aulast=Zhang&rft.aufirst=Peijun&rft.date=2007-03-06&rft.volume=104&rft.issue=10&rft.spage=3777&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - adaptor proteins; Chemoreceptors; CheW protein; Histidine; Tomography; Invaginations; Chemotaxis; CheA protein; Signal transduction; Escherichia coli ER - TY - CPAPER T1 - Identification of a Novel, Point Mutation in Helix 11 of the Ligand-Binding Domain of the Human Glucocorticoid Receptor-a (hGRa) Gene and Molecular Characterization of the Mutant Receptor hGRaF737L T2 - 2007 BES Conference of the Society for Endocrinology AN - 39349365; 4595065 JF - 2007 BES Conference of the Society for Endocrinology AU - Charmandari, Evangelia AU - Kino, Tomoshige AU - Ichijo, Takamasa AU - Zachman, Keith AU - Chrousos, George Y1 - 2007/03/05/ PY - 2007 DA - 2007 Mar 05 KW - Point mutation KW - Mutants KW - Glucocorticoids KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39349365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+BES+Conference+of+the+Society+for+Endocrinology&rft.atitle=Identification+of+a+Novel%2C+Point+Mutation+in+Helix+11+of+the+Ligand-Binding+Domain+of+the+Human+Glucocorticoid+Receptor-a+%28hGRa%29+Gene+and+Molecular+Characterization+of+the+Mutant+Receptor+hGRaF737L&rft.au=Charmandari%2C+Evangelia%3BKino%2C+Tomoshige%3BIchijo%2C+Takamasa%3BZachman%2C+Keith%3BChrousos%2C+George&rft.aulast=Charmandari&rft.aufirst=Evangelia&rft.date=2007-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+BES+Conference+of+the+Society+for+Endocrinology&rft.issn=&rft_id=info:doi/ L2 - http://www.endocrine-abstracts.org/ea/0013/default.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Wnt/b-Catenin Signalling is Abrogated in Mice with a Targeted Mutation in the Thyroid Hormone Receptor (TR) b Gene and a Thyrotoxic Skeletal Phenotype T2 - 2007 BES Conference of the Society for Endocrinology AN - 39333891; 4594813 JF - 2007 BES Conference of the Society for Endocrinology AU - O'shea, Patrick J AU - Davis, Sean AU - Walker, Robert L AU - Meltzer, Paul S AU - Williams, Graham R AU - Cheng, Sheue-yann Y1 - 2007/03/05/ PY - 2007 DA - 2007 Mar 05 KW - Mutation KW - Mice KW - Hormones KW - Thyroid hormone receptors KW - Signal transduction KW - Wnt protein KW - Catenin KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39333891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+BES+Conference+of+the+Society+for+Endocrinology&rft.atitle=Wnt%2Fb-Catenin+Signalling+is+Abrogated+in+Mice+with+a+Targeted+Mutation+in+the+Thyroid+Hormone+Receptor+%28TR%29+b+Gene+and+a+Thyrotoxic+Skeletal+Phenotype&rft.au=O%27shea%2C+Patrick+J%3BDavis%2C+Sean%3BWalker%2C+Robert+L%3BMeltzer%2C+Paul+S%3BWilliams%2C+Graham+R%3BCheng%2C+Sheue-yann&rft.aulast=O%27shea&rft.aufirst=Patrick&rft.date=2007-03-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+BES+Conference+of+the+Society+for+Endocrinology&rft.issn=&rft_id=info:doi/ L2 - http://www.endocrine-abstracts.org/ea/0013/default.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate AN - 19779596; 7308703 AB - In eukaryotic cells, many short-lived proteins are conjugated with Lys 48- linked ubiquitin chains and degraded by the proteasome. Ubiquitination requires an activating enzyme (E1), a conjugating enzyme (E2) and a ligase (E3). Most ubiquitin ligases use either a HECT (homologous to E6-associated protein C terminus) or a RING (really interesting new gene) domain to catalyse polyubiquitination, but the mechanism of E3 catalysis is poorly defined. Here we dissect this process using mouse Ube2g2 (E2; identical at the amino acid level to human Ube2g2) and human gp78 (E3), an endoplasmic reticulum (ER)-associated conjugating system essential for the degradation of misfolded ER proteins. We demonstrate by expressing recombinant proteins in Escherichia coli that Ube2g2/gp78-mediated polyubiquitination involves preassembly of Lys 48-linked ubiquitin chains at the catalytic cysteine of Ube2g2. The growth of Ube2g2- anchored ubiquitin chains seems to be mediated by an aminolysis-based transfer reaction between two Ube2g2 molecules that each carries a ubiquitin moiety in its active site. Intriguingly, polyubiquitination of a substrate can be achieved by transferring preassembled ubiquitin chains from Ube2g2 to a lysine residue in a substrate. JF - Nature AU - Li, Wei AU - Tu, Daqi AU - Brunger, Axel T AU - Ye, Yihong AD - Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA, yihongy@mail.nih.gov PY - 2007 SP - 333 EP - 337 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 446 IS - 7133 SN - 0028-0836, 0028-0836 KW - Microbiology Abstracts B: Bacteriology KW - Amino acids KW - protein C KW - proteasomes KW - Enzymes KW - Lysine KW - Ubiquitin-protein ligase KW - Endoplasmic reticulum KW - ubiquitination KW - Cysteine KW - Escherichia coli KW - Ubiquitin KW - Catalysis KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19779596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=A+ubiquitin+ligase+transfers+preformed+polyubiquitin+chains+from+a+conjugating+enzyme+to+a+substrate&rft.au=Li%2C+Wei%3BTu%2C+Daqi%3BBrunger%2C+Axel+T%3BYe%2C+Yihong&rft.aulast=Li&rft.aufirst=Wei&rft.date=2007-03-05&rft.volume=446&rft.issue=7133&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/10.1038%2Fnature05542 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - ubiquitination; Endoplasmic reticulum; Amino acids; protein C; Cysteine; proteasomes; Lysine; Enzymes; Catalysis; Ubiquitin-protein ligase; Ubiquitin; Escherichia coli DO - http://dx.doi.org/10.1038/nature05542 ER - TY - CPAPER T1 - Which Form of VEGF can Guide Endothelial Cell Migration? T2 - 51st Annual Meeting of the Biophysical Society AN - 40684192; 4582008 JF - 51st Annual Meeting of the Biophysical Society AU - Small, Alexander R AU - Neagu, Adrian AU - Amyot, Franck AU - Sackett, Dan AU - Chernomordik, Victor AU - Gandjbakhche, Amir Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Cell migration KW - Endothelial cells KW - Vascular endothelial growth factor KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40684192?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Which+Form+of+VEGF+can+Guide+Endothelial+Cell+Migration%3F&rft.au=Small%2C+Alexander+R%3BNeagu%2C+Adrian%3BAmyot%2C+Franck%3BSackett%2C+Dan%3BChernomordik%2C+Victor%3BGandjbakhche%2C+Amir&rft.aulast=Small&rft.aufirst=Alexander&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - bXin: Genes, Splice Variants and Cellular Distribution of a Family of Proteins Implicated in the Myofibrillogenesis of Striated Muscles. T2 - 51st Annual Meeting of the Biophysical Society AN - 40681003; 4581889 JF - 51st Annual Meeting of the Biophysical Society AU - Xie, Ling AU - Gutierrez-Cruz, Gustavo AU - Tsai, Wanxia L AU - Wang, Kuan Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Muscles KW - Alternative splicing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40681003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=bXin%3A+Genes%2C+Splice+Variants+and+Cellular+Distribution+of+a+Family+of+Proteins+Implicated+in+the+Myofibrillogenesis+of+Striated+Muscles.&rft.au=Xie%2C+Ling%3BGutierrez-Cruz%2C+Gustavo%3BTsai%2C+Wanxia+L%3BWang%2C+Kuan&rft.aulast=Xie&rft.aufirst=Ling&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Conformationally Regulated Uptake of Nitrite by Deoxyhemoglobin and Release of the NO Produced T2 - 51st Annual Meeting of the Biophysical Society AN - 40676009; 4581140 JF - 51st Annual Meeting of the Biophysical Society AU - Rifkind, Joseph M AU - Ramasamy, Somasundaram AU - Nagababu, Enika Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Nitrite KW - Nitric oxide KW - Uptake KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40676009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Conformationally+Regulated+Uptake+of+Nitrite+by+Deoxyhemoglobin+and+Release+of+the+NO+Produced&rft.au=Rifkind%2C+Joseph+M%3BRamasamy%2C+Somasundaram%3BNagababu%2C+Enika&rft.aulast=Rifkind&rft.aufirst=Joseph&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural Changes in Lactose Permease and how Sugar-Type Effects Binding Structure T2 - 51st Annual Meeting of the Biophysical Society AN - 40675387; 4581185 JF - 51st Annual Meeting of the Biophysical Society AU - Klauda, Jeffery B AU - Brooks, Bernard R Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Lactose permease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40675387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Structural+Changes+in+Lactose+Permease+and+how+Sugar-Type+Effects+Binding+Structure&rft.au=Klauda%2C+Jeffery+B%3BBrooks%2C+Bernard+R&rft.aulast=Klauda&rft.aufirst=Jeffery&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural Characterization of Peptides from Phage-Display Libraries T2 - 51st Annual Meeting of the Biophysical Society AN - 40674254; 4581163 JF - 51st Annual Meeting of the Biophysical Society AU - Cachau, Raul E AU - Krumpe, Lauren R.H. AU - Mori, Toshiyuki AU - Ventura, Oscar N AU - Burt, Stanley K Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Libraries KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40674254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Structural+Characterization+of+Peptides+from+Phage-Display+Libraries&rft.au=Cachau%2C+Raul+E%3BKrumpe%2C+Lauren+R.H.%3BMori%2C+Toshiyuki%3BVentura%2C+Oscar+N%3BBurt%2C+Stanley+K&rft.aulast=Cachau&rft.aufirst=Raul&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Protein-Protein Interactions in a Nitrogen Signal Pathway of E. coli T2 - 51st Annual Meeting of the Biophysical Society AN - 40674098; 4581105 JF - 51st Annual Meeting of the Biophysical Society AU - Piszczek, Grzegorz AU - Fodor, Elfrieda AU - Peterkofsky, Alan AU - Ginsburg, Ann Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Nitrogen KW - Protein interaction KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40674098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Protein-Protein+Interactions+in+a+Nitrogen+Signal+Pathway+of+E.+coli&rft.au=Piszczek%2C+Grzegorz%3BFodor%2C+Elfrieda%3BPeterkofsky%2C+Alan%3BGinsburg%2C+Ann&rft.aulast=Piszczek&rft.aufirst=Grzegorz&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cyclodextrin Differentially Extracts Cholesterol from Cells and their Membranes T2 - 51st Annual Meeting of the Biophysical Society AN - 40673635; 4581669 JF - 51st Annual Meeting of the Biophysical Society AU - Bezrukov, Ludmila AU - Blank, Paul S AU - Polozov, Ivan V AU - Zimmerberg, Josh Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Membranes KW - Cholesterol KW - Cyclodextrin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40673635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Cyclodextrin+Differentially+Extracts+Cholesterol+from+Cells+and+their+Membranes&rft.au=Bezrukov%2C+Ludmila%3BBlank%2C+Paul+S%3BPolozov%2C+Ivan+V%3BZimmerberg%2C+Josh&rft.aulast=Bezrukov&rft.aufirst=Ludmila&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fast Pattern Recognition of Protein Three Dimensional Features using a Bit-Pattern Approach as a Prescreen. T2 - 51st Annual Meeting of the Biophysical Society AN - 40673364; 4581632 JF - 51st Annual Meeting of the Biophysical Society AU - Yen, Phillip AU - Ventura, Oscar N AU - Burt, Stanley K AU - Cachau, Raul E Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Pattern recognition KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40673364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Fast+Pattern+Recognition+of+Protein+Three+Dimensional+Features+using+a+Bit-Pattern+Approach+as+a+Prescreen.&rft.au=Yen%2C+Phillip%3BVentura%2C+Oscar+N%3BBurt%2C+Stanley+K%3BCachau%2C+Raul+E&rft.aulast=Yen&rft.aufirst=Phillip&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Scanning Transmission Electron Microscopy Mass-Per-Length Analysis and Electron Diffraction Support the Stacked b-Solenoid Model of HET-s Prion Fibrils T2 - 51st Annual Meeting of the Biophysical Society AN - 40673360; 4581596 JF - 51st Annual Meeting of the Biophysical Society AU - Sen, Anindito AU - Baxa, Ulrich AU - Simon, Martha N AU - Wall, Joseph S AU - Sabate, Raimon AU - Saupe, Sven J AU - Steven, Alasdair C Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Transmission electron microscopy KW - Prion protein KW - Electron diffraction KW - Models KW - Fibrils KW - Diffraction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40673360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Scanning+Transmission+Electron+Microscopy+Mass-Per-Length+Analysis+and+Electron+Diffraction+Support+the+Stacked+b-Solenoid+Model+of+HET-s+Prion+Fibrils&rft.au=Sen%2C+Anindito%3BBaxa%2C+Ulrich%3BSimon%2C+Martha+N%3BWall%2C+Joseph+S%3BSabate%2C+Raimon%3BSaupe%2C+Sven+J%3BSteven%2C+Alasdair+C&rft.aulast=Sen&rft.aufirst=Anindito&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nanostructure Design using Protein Building Blocks T2 - 51st Annual Meeting of the Biophysical Society AN - 40673319; 4581615 DE: JF - 51st Annual Meeting of the Biophysical Society AU - Zheng, Jie AU - Tsai, Chung-Jung AU - Nussinov, Ruth Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40673319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Nanostructure+Design+using+Protein+Building+Blocks&rft.au=Zheng%2C+Jie%3BTsai%2C+Chung-Jung%3BNussinov%2C+Ruth&rft.aulast=Zheng&rft.aufirst=Jie&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - VSTx1 Stabilizes a Closed State in K@@dv@2.1-K@@dv@AP Paddle Chimeras T2 - 51st Annual Meeting of the Biophysical Society AN - 40673169; 4581561 JF - 51st Annual Meeting of the Biophysical Society AU - Alabi, AbdulRasheed A AU - Swartz, Kenton J Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Potassium channels (voltage-gated) KW - Chimeras KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40673169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=VSTx1+Stabilizes+a+Closed+State+in+K%40%40dv%402.1-K%40%40dv%40AP+Paddle+Chimeras&rft.au=Alabi%2C+AbdulRasheed+A%3BSwartz%2C+Kenton+J&rft.aulast=Alabi&rft.aufirst=AbdulRasheed&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Probing the Internal Organization of the Monomers in the Influenza Hemagglutinin. T2 - 51st Annual Meeting of the Biophysical Society AN - 40673133; 4581668 JF - 51st Annual Meeting of the Biophysical Society AU - Fera, Andrea AU - Farrington, Jane E AU - Hess, Samuel T AU - Chen, Xiaobing AU - Mekhedov, Elena AU - Yin, Shu-Rong AU - Reese, Thomas AU - Zimmerberg, Joshua Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Influenza KW - Monomers KW - Hemagglutinins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40673133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Probing+the+Internal+Organization+of+the+Monomers+in+the+Influenza+Hemagglutinin.&rft.au=Fera%2C+Andrea%3BFarrington%2C+Jane+E%3BHess%2C+Samuel+T%3BChen%2C+Xiaobing%3BMekhedov%2C+Elena%3BYin%2C+Shu-Rong%3BReese%2C+Thomas%3BZimmerberg%2C+Joshua&rft.aulast=Fera&rft.aufirst=Andrea&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Free Fatty Acids Alter the Function of Inhibitory Ligand Gated Ion Channels. T2 - 51st Annual Meeting of the Biophysical Society AN - 40672629; 4581469 JF - 51st Annual Meeting of the Biophysical Society AU - Kloda, Jessica H AU - Mitchell, Drake C Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Channels KW - Fatty acids KW - Ion channels KW - Ligands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40672629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Free+Fatty+Acids+Alter+the+Function+of+Inhibitory+Ligand+Gated+Ion+Channels.&rft.au=Kloda%2C+Jessica+H%3BMitchell%2C+Drake+C&rft.aulast=Kloda&rft.aufirst=Jessica&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gated Accessibility of MTS Reagents to the Pore of P2X Receptor Channels T2 - 51st Annual Meeting of the Biophysical Society AN - 40672591; 4581460 JF - 51st Annual Meeting of the Biophysical Society AU - Li, Mufeng AU - Silberberg, Shai D AU - Swartz, Kenton J Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Channels KW - Channel pores KW - Purine P2X receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40672591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Gated+Accessibility+of+MTS+Reagents+to+the+Pore+of+P2X+Receptor+Channels&rft.au=Li%2C+Mufeng%3BSilberberg%2C+Shai+D%3BSwartz%2C+Kenton+J&rft.aulast=Li&rft.aufirst=Mufeng&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reconstruction of Membrane Budding by Viral Matrix Protein T2 - 51st Annual Meeting of the Biophysical Society AN - 40672575; 4581363 JF - 51st Annual Meeting of the Biophysical Society AU - Shnyrova, Anna AU - Ayllon, Juan AU - Villar, Enrique AU - Zimmerberg, Joshua AU - Frolov, Vadim A Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Membranes KW - Budding KW - Matrix protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40672575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Reconstruction+of+Membrane+Budding+by+Viral+Matrix+Protein&rft.au=Shnyrova%2C+Anna%3BAyllon%2C+Juan%3BVillar%2C+Enrique%3BZimmerberg%2C+Joshua%3BFrolov%2C+Vadim+A&rft.aulast=Shnyrova&rft.aufirst=Anna&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structure, Dynamics, and Location of the Endocannabinoid 2-AG in Lipid Bilayers - An NMR and Neutron Diffraction Study T2 - 51st Annual Meeting of the Biophysical Society AN - 40672514; 4581394 JF - 51st Annual Meeting of the Biophysical Society AU - Gawrisch, Klaus AU - Eldho, Nadukkudy V AU - Mihailescu, Ella AU - Kimura, Tomohiro Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - N.M.R. KW - Lipid bilayers KW - Cannabinoids KW - Neutron diffraction KW - Diffraction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40672514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Structure%2C+Dynamics%2C+and+Location+of+the+Endocannabinoid+2-AG+in+Lipid+Bilayers+-+An+NMR+and+Neutron+Diffraction+Study&rft.au=Gawrisch%2C+Klaus%3BEldho%2C+Nadukkudy+V%3BMihailescu%2C+Ella%3BKimura%2C+Tomohiro&rft.aulast=Gawrisch&rft.aufirst=Klaus&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fluorescence Based Studies of Endophilin B Proteins and their Interaction with Lipid Membranes T2 - 51st Annual Meeting of the Biophysical Society AN - 40672428; 4581674 JF - 51st Annual Meeting of the Biophysical Society AU - Shiu, Brian AU - Boukari, Hacene AU - Banerjee, Soojay AU - Silver, Jonathan AU - Youle, Richard J AU - Bezrukov, Sergey M AU - Rostovtseva, Tatiana K Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Lipid membranes KW - Fluorescence KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40672428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Fluorescence+Based+Studies+of+Endophilin+B+Proteins+and+their+Interaction+with+Lipid+Membranes&rft.au=Shiu%2C+Brian%3BBoukari%2C+Hacene%3BBanerjee%2C+Soojay%3BSilver%2C+Jonathan%3BYoule%2C+Richard+J%3BBezrukov%2C+Sergey+M%3BRostovtseva%2C+Tatiana+K&rft.aulast=Shiu&rft.aufirst=Brian&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tubulin Regulates VDAC Channel T2 - 51st Annual Meeting of the Biophysical Society AN - 40672418; 4581402 JF - 51st Annual Meeting of the Biophysical Society AU - Rostovtseva, Tatiana K AU - Hassanzadeh, Elnaz AU - Sackett, Dan L AU - Bezrukov, Sergey M Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Channels KW - Tubulin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40672418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Tubulin+Regulates+VDAC+Channel&rft.au=Rostovtseva%2C+Tatiana+K%3BHassanzadeh%2C+Elnaz%3BSackett%2C+Dan+L%3BBezrukov%2C+Sergey+M&rft.aulast=Rostovtseva&rft.aufirst=Tatiana&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Swelling and Biomechanical Properties of Tissue-Engineering Cartilage T2 - 51st Annual Meeting of the Biophysical Society AN - 40672417; 4581063 JF - 51st Annual Meeting of the Biophysical Society AU - Lin, David C AU - Dimitriadis, Emilios K AU - Horkayne-Szakaly, Iren AU - Basser, Peter J AU - Horkay, Ferenc Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Biomechanics KW - Mechanical properties KW - Cartilage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40672417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Swelling+and+Biomechanical+Properties+of+Tissue-Engineering+Cartilage&rft.au=Lin%2C+David+C%3BDimitriadis%2C+Emilios+K%3BHorkayne-Szakaly%2C+Iren%3BBasser%2C+Peter+J%3BHorkay%2C+Ferenc&rft.aulast=Lin&rft.aufirst=David&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Degradation of the Bacterial Cell Division Protein FtsZ by ClpXP T2 - 51st Annual Meeting of the Biophysical Society AN - 40672407; 4581243 JF - 51st Annual Meeting of the Biophysical Society AU - Camberg, Jodi L AU - Hoskins, Joel AU - Wickner, Sue Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Cell division KW - Biodegradation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40672407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Degradation+of+the+Bacterial+Cell+Division+Protein+FtsZ+by+ClpXP&rft.au=Camberg%2C+Jodi+L%3BHoskins%2C+Joel%3BWickner%2C+Sue&rft.aulast=Camberg&rft.aufirst=Jodi&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Induced-Fit Mechanism for Substrate Entry and Enzyme Catalysis in Prolyl Endopeptidase. T2 - 51st Annual Meeting of the Biophysical Society AN - 40672221; 4581147 JF - 51st Annual Meeting of the Biophysical Society AU - Chiu, Thang K AU - Li, Min AU - Davies, David R Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Catalysis KW - Enzymes KW - Prolyl oligopeptidase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40672221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=An+Induced-Fit+Mechanism+for+Substrate+Entry+and+Enzyme+Catalysis+in+Prolyl+Endopeptidase.&rft.au=Chiu%2C+Thang+K%3BLi%2C+Min%3BDavies%2C+David+R&rft.aulast=Chiu&rft.aufirst=Thang&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Anion Binding Site in Kainate Receptors T2 - 51st Annual Meeting of the Biophysical Society AN - 40672206; 4581485 JF - 51st Annual Meeting of the Biophysical Society AU - Plested, Andrew J AU - Mayer, Mark L Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Anions KW - Glutamic acid receptors KW - Kainic acid receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40672206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=The+Anion+Binding+Site+in+Kainate+Receptors&rft.au=Plested%2C+Andrew+J%3BMayer%2C+Mark+L&rft.aulast=Plested&rft.aufirst=Andrew&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interactions of E.coli ClpXP with RssB Adapter Protein and Sigma(S) T2 - 51st Annual Meeting of the Biophysical Society AN - 40672046; 4581242 JF - 51st Annual Meeting of the Biophysical Society AU - Hoskins, Joel R AU - Wickner, Sue Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Adaptor proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40672046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Interactions+of+E.coli+ClpXP+with+RssB+Adapter+Protein+and+Sigma%28S%29&rft.au=Hoskins%2C+Joel+R%3BWickner%2C+Sue&rft.aulast=Hoskins&rft.aufirst=Joel&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phagositic Clearance of Electric Field Induced 'Apoptosis Mimetic' Cells T2 - 51st Annual Meeting of the Biophysical Society AN - 40671780; 4581329 JF - 51st Annual Meeting of the Biophysical Society AU - Tekle, Ephrem AU - Wolfe, Matt AU - Chock, P B Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Electric fields KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40671780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Phagositic+Clearance+of+Electric+Field+Induced+%27Apoptosis+Mimetic%27+Cells&rft.au=Tekle%2C+Ephrem%3BWolfe%2C+Matt%3BChock%2C+P+B&rft.aulast=Tekle&rft.aufirst=Ephrem&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Universal One-Parameter Equation of State for Osmotic Pressures of Neutral Flexible Polymers in Good Solvents T2 - 51st Annual Meeting of the Biophysical Society AN - 40671361; 4581066 JF - 51st Annual Meeting of the Biophysical Society AU - Cohen, Joel A AU - Podgornik, Rudi AU - Hansen, Per Lyngs AU - Parsegian, V Adrian Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Solvents KW - Polymers KW - Mathematical models KW - Osmotic pressure KW - Equations of state KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40671361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=A+Universal+One-Parameter+Equation+of+State+for+Osmotic+Pressures+of+Neutral+Flexible+Polymers+in+Good+Solvents&rft.au=Cohen%2C+Joel+A%3BPodgornik%2C+Rudi%3BHansen%2C+Per+Lyngs%3BParsegian%2C+V+Adrian&rft.aulast=Cohen&rft.aufirst=Joel&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetically Encoded FRET Efficiency Standards T2 - 51st Annual Meeting of the Biophysical Society AN - 40671219; 4581004 JF - 51st Annual Meeting of the Biophysical Society AU - Koushik, Srinagesh V AU - Chen, Huanmian AU - Thaler, Christopher AU - Puhl III, Henry L AU - Vogel, Steven S Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Fluorescence resonance energy transfer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40671219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Genetically+Encoded+FRET+Efficiency+Standards&rft.au=Koushik%2C+Srinagesh+V%3BChen%2C+Huanmian%3BThaler%2C+Christopher%3BPuhl+III%2C+Henry+L%3BVogel%2C+Steven+S&rft.aulast=Koushik&rft.aufirst=Srinagesh&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Simulation of Slow Conformational Dynamics of the Calmodulin C-Domain T2 - 51st Annual Meeting of the Biophysical Society AN - 40671057; 4581764 JF - 51st Annual Meeting of the Biophysical Society AU - Chen, Yng-Gwei AU - Hummer, Gerhard Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Simulation KW - Calmodulin KW - Calcium-binding protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40671057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Simulation+of+Slow+Conformational+Dynamics+of+the+Calmodulin+C-Domain&rft.au=Chen%2C+Yng-Gwei%3BHummer%2C+Gerhard&rft.aulast=Chen&rft.aufirst=Yng-Gwei&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tubulin Carboxy-Terminal Tail Conformation is pH Sensitive T2 - 51st Annual Meeting of the Biophysical Society AN - 40670965; 4580943 JF - 51st Annual Meeting of the Biophysical Society AU - Sackett, Dan L Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - PH KW - PH effects KW - Tails KW - Conformation KW - Tubulin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40670965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Tubulin+Carboxy-Terminal+Tail+Conformation+is+pH+Sensitive&rft.au=Sackett%2C+Dan+L&rft.aulast=Sackett&rft.aufirst=Dan&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Estimating Protein-Protein Interaction Affinity in Living Cells using Quantitative FRET Measurements T2 - 51st Annual Meeting of the Biophysical Society AN - 40670526; 4581003 JF - 51st Annual Meeting of the Biophysical Society AU - Chen, Huanmian AU - Puhl III, Henry L AU - Ikeda, Stephen R Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Affinity KW - Fluorescence resonance energy transfer KW - Protein interaction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40670526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Estimating+Protein-Protein+Interaction+Affinity+in+Living+Cells+using+Quantitative+FRET+Measurements&rft.au=Chen%2C+Huanmian%3BPuhl+III%2C+Henry+L%3BIkeda%2C+Stephen+R&rft.aulast=Chen&rft.aufirst=Huanmian&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Method for Analyzing Cell Surface Protein Density using Intensity Cumulative Distribution Functions T2 - 51st Annual Meeting of the Biophysical Society AN - 40670006; 4581656 JF - 51st Annual Meeting of the Biophysical Society AU - Mekhedov, Elena AU - Blank, Paul S AU - Yin, Shu-Rong AU - Zimmerberg, Joshua Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Cell surface KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40670006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=A+Novel+Method+for+Analyzing+Cell+Surface+Protein+Density+using+Intensity+Cumulative+Distribution+Functions&rft.au=Mekhedov%2C+Elena%3BBlank%2C+Paul+S%3BYin%2C+Shu-Rong%3BZimmerberg%2C+Joshua&rft.aulast=Mekhedov&rft.aufirst=Elena&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural and Thermodynamic Studies of a Ribosomal Protein - RNA - Antibiotic Complex T2 - 51st Annual Meeting of the Biophysical Society AN - 40669717; 4582382 JF - 51st Annual Meeting of the Biophysical Society AU - Lee, Donghan AU - Bianchi, Kristin AU - Walsh, Joseph D AU - Yu, Ping AU - Wang, Yun-Xing AU - Draper, David Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Antibiotics KW - Thermodynamics KW - RRNA KW - RNA KW - Ribosomal proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40669717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Structural+and+Thermodynamic+Studies+of+a+Ribosomal+Protein+-+RNA+-+Antibiotic+Complex&rft.au=Lee%2C+Donghan%3BBianchi%2C+Kristin%3BWalsh%2C+Joseph+D%3BYu%2C+Ping%3BWang%2C+Yun-Xing%3BDraper%2C+David&rft.aulast=Lee&rft.aufirst=Donghan&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pore Formation in Lipid Membranes Containing Lysolipids and Cholesterol T2 - 51st Annual Meeting of the Biophysical Society AN - 40669236; 4581349 JF - 51st Annual Meeting of the Biophysical Society AU - Karpunin, Dmitry V AU - Akimov, Sergei A AU - Zimmerberg, Joshua AU - Frolov, Vadim A Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Lipid membranes KW - Cholesterol KW - Pores KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40669236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Pore+Formation+in+Lipid+Membranes+Containing+Lysolipids+and+Cholesterol&rft.au=Karpunin%2C+Dmitry+V%3BAkimov%2C+Sergei+A%3BZimmerberg%2C+Joshua%3BFrolov%2C+Vadim+A&rft.aulast=Karpunin&rft.aufirst=Dmitry&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Electron Tomographic Analysis of HIV-1 Envelope Glycoproteins T2 - 51st Annual Meeting of the Biophysical Society AN - 40667846; 4582231 JF - 51st Annual Meeting of the Biophysical Society AU - Bennett, Adam E AU - Liu, Jun AU - Sougrat, Rachid AU - Subramaniam, Sriram Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Glycoproteins KW - Envelopes KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40667846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Electron+Tomographic+Analysis+of+HIV-1+Envelope+Glycoproteins&rft.au=Bennett%2C+Adam+E%3BLiu%2C+Jun%3BSougrat%2C+Rachid%3BSubramaniam%2C+Sriram&rft.aulast=Bennett&rft.aufirst=Adam&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - 3D Structure of a Predatory Bacterium T2 - 51st Annual Meeting of the Biophysical Society AN - 40667817; 4582229 JF - 51st Annual Meeting of the Biophysical Society AU - Borgnia, Mario J AU - Subramaniam, Sriram AU - Milne, Jacqueline L.S. Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Electron microscopy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40667817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=3D+Structure+of+a+Predatory+Bacterium&rft.au=Borgnia%2C+Mario+J%3BSubramaniam%2C+Sriram%3BMilne%2C+Jacqueline+L.S.&rft.aulast=Borgnia&rft.aufirst=Mario&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural Models of Lattice, Fibril, and Membrane-Bound Assemblies Formed by the PrP@@uSc@ Prion Protein T2 - 51st Annual Meeting of the Biophysical Society AN - 40667773; 4581595 JF - 51st Annual Meeting of the Biophysical Society AU - Guy, H Robert AU - Durell, Stewart R Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Prion protein KW - Models KW - Fibrils KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40667773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Structural+Models+of+Lattice%2C+Fibril%2C+and+Membrane-Bound+Assemblies+Formed+by+the+PrP%40%40uSc%40+Prion+Protein&rft.au=Guy%2C+H+Robert%3BDurell%2C+Stewart+R&rft.aulast=Guy&rft.aufirst=H&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Probing Mechanical Responses of Influenza Viral Particles by Imaging and Nano-Manipulation with an Atomic Force Microscope. T2 - 51st Annual Meeting of the Biophysical Society AN - 40666264; 4582242 JF - 51st Annual Meeting of the Biophysical Society AU - Kotova, Svetlana AU - Dimitriadis, Emilios K AU - Berzukov, Ludmila AU - Zimmerberg, Joshua AU - Fera, Andrea Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Particulates KW - Influenza KW - Imaging techniques KW - Atomic force microscopy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40666264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Probing+Mechanical+Responses+of+Influenza+Viral+Particles+by+Imaging+and+Nano-Manipulation+with+an+Atomic+Force+Microscope.&rft.au=Kotova%2C+Svetlana%3BDimitriadis%2C+Emilios+K%3BBerzukov%2C+Ludmila%3BZimmerberg%2C+Joshua%3BFera%2C+Andrea&rft.aulast=Kotova&rft.aufirst=Svetlana&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Three-Dimensional Visualization of Cancer Cells at 50 nm Resolution using Dual Beam Microscopy T2 - 51st Annual Meeting of the Biophysical Society AN - 40666178; 4582228 JF - 51st Annual Meeting of the Biophysical Society AU - Heymann, Jurgen A.W. AU - Kim, Sang AU - Shi, Dan AU - Subramaniam, Sriram Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Cancer KW - Microscopy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40666178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Three-Dimensional+Visualization+of+Cancer+Cells+at+50+nm+Resolution+using+Dual+Beam+Microscopy&rft.au=Heymann%2C+Jurgen+A.W.%3BKim%2C+Sang%3BShi%2C+Dan%3BSubramaniam%2C+Sriram&rft.aulast=Heymann&rft.aufirst=Jurgen&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Architecture of the Icosahedral Pyruvate Dehydrogenase Complex T2 - 51st Annual Meeting of the Biophysical Society AN - 40666080; 4582230 JF - 51st Annual Meeting of the Biophysical Society AU - Lengyel, Jeffrey S AU - Wu, Xiongwu AU - Stott, Katherine M AU - Schuck, Peter AU - Perham, Richard N AU - Subramaniam, Sriram AU - Milne, Jacqueline L.S. Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Pyruvate dehydrogenase (lipoamide) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40666080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Molecular+Architecture+of+the+Icosahedral+Pyruvate+Dehydrogenase+Complex&rft.au=Lengyel%2C+Jeffrey+S%3BWu%2C+Xiongwu%3BStott%2C+Katherine+M%3BSchuck%2C+Peter%3BPerham%2C+Richard+N%3BSubramaniam%2C+Sriram%3BMilne%2C+Jacqueline+L.S.&rft.aulast=Lengyel&rft.aufirst=Jeffrey&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Defective Cell-Matrix Attachment due to Reduction of Beta1-Integrin Expression in Nonmuscle Myosin II Null Mouse Embryonic Fibroblasts T2 - 51st Annual Meeting of the Biophysical Society AN - 40666051; 4582137 JF - 51st Annual Meeting of the Biophysical Society AU - Kim, Kye-Young AU - Adelstein, Robert S Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Fibroblasts KW - Embryos KW - Myosin KW - Embryo fibroblasts KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40666051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Defective+Cell-Matrix+Attachment+due+to+Reduction+of+Beta1-Integrin+Expression+in+Nonmuscle+Myosin+II+Null+Mouse+Embryonic+Fibroblasts&rft.au=Kim%2C+Kye-Young%3BAdelstein%2C+Robert+S&rft.aulast=Kim&rft.aufirst=Kye-Young&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Framework for Classification and Averaging of 3D Tomographic Volumes T2 - 51st Annual Meeting of the Biophysical Society AN - 40665398; 4582224 JF - 51st Annual Meeting of the Biophysical Society AU - Bartesaghi, Alberto AU - Sprechmann, Pablo AU - Randall, Gregory AU - Sapiro, Guillermo AU - Subramaniam, Sriram Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Classification KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40665398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=A+Framework+for+Classification+and+Averaging+of+3D+Tomographic+Volumes&rft.au=Bartesaghi%2C+Alberto%3BSprechmann%2C+Pablo%3BRandall%2C+Gregory%3BSapiro%2C+Guillermo%3BSubramaniam%2C+Sriram&rft.aulast=Bartesaghi&rft.aufirst=Alberto&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantitative Assay to Study Cell Motility on Collagen Film T2 - 51st Annual Meeting of the Biophysical Society AN - 40665149; 4582104 JF - 51st Annual Meeting of the Biophysical Society AU - Amyot, Franck AU - Small, Alex AU - Boukari, Hacene AU - Plant, Anne AU - McDaniel, Denis AU - Gandjbakhche, Amir Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Films KW - Cell migration KW - Collagen KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40665149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Quantitative+Assay+to+Study+Cell+Motility+on+Collagen+Film&rft.au=Amyot%2C+Franck%3BSmall%2C+Alex%3BBoukari%2C+Hacene%3BPlant%2C+Anne%3BMcDaniel%2C+Denis%3BGandjbakhche%2C+Amir&rft.aulast=Amyot&rft.aufirst=Franck&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nanomechanics of Intrinsically Disordered Muscle Proteins: Computational Approaches T2 - 51st Annual Meeting of the Biophysical Society AN - 40664996; 4582293 JF - 51st Annual Meeting of the Biophysical Society AU - Forbes, Jeffrey G AU - Wang, Kuan Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Muscles KW - Computer applications KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40664996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Nanomechanics+of+Intrinsically+Disordered+Muscle+Proteins%3A+Computational+Approaches&rft.au=Forbes%2C+Jeffrey+G%3BWang%2C+Kuan&rft.aulast=Forbes&rft.aufirst=Jeffrey&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reconstitution of a Human Peripheral Cannabinoid Receptor CB2 into Phosphatidylcholine Proteoliposomes T2 - 51st Annual Meeting of the Biophysical Society AN - 40664728; 4582340 JF - 51st Annual Meeting of the Biophysical Society AU - Kimura, Tomohiro AU - Yeliseev, Alexei A AU - Rhodes, Steven D AU - Gawrisch, Klaus Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Cannabinoid CB2 receptors KW - Lecithin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40664728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Reconstitution+of+a+Human+Peripheral+Cannabinoid+Receptor+CB2+into+Phosphatidylcholine+Proteoliposomes&rft.au=Kimura%2C+Tomohiro%3BYeliseev%2C+Alexei+A%3BRhodes%2C+Steven+D%3BGawrisch%2C+Klaus&rft.aulast=Kimura&rft.aufirst=Tomohiro&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantitative Three-Dimensional Elemental Mapping of Phosphorus using EFTEM Tomography T2 - 51st Annual Meeting of the Biophysical Society AN - 40664340; 4582227 JF - 51st Annual Meeting of the Biophysical Society AU - Aronova, Maria A AU - Kim, Youngchan AU - Sousa, Alioscka A AU - Zhang, Guofeng AU - Leapman, Richard D Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Phosphorus KW - Mapping KW - Tomography KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40664340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Quantitative+Three-Dimensional+Elemental+Mapping+of+Phosphorus+using+EFTEM+Tomography&rft.au=Aronova%2C+Maria+A%3BKim%2C+Youngchan%3BSousa%2C+Alioscka+A%3BZhang%2C+Guofeng%3BLeapman%2C+Richard+D&rft.aulast=Aronova&rft.aufirst=Maria&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Modeling Strategies for the Computational Characterization of Nanobioparticles T2 - 51st Annual Meeting of the Biophysical Society AN - 40664297; 4580398 JF - 51st Annual Meeting of the Biophysical Society AU - Cachau, Raul E AU - Fritts, Martin J AU - Topol, Igor AU - Burt, Stanley K AU - Gonzalez-Nilo, Fernando D AU - Matties, Mark Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Computer applications KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40664297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=New+Modeling+Strategies+for+the+Computational+Characterization+of+Nanobioparticles&rft.au=Cachau%2C+Raul+E%3BFritts%2C+Martin+J%3BTopol%2C+Igor%3BBurt%2C+Stanley+K%3BGonzalez-Nilo%2C+Fernando+D%3BMatties%2C+Mark&rft.aulast=Cachau&rft.aufirst=Raul&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - C. elegans EFF-1 Mediates Homotypic Fusion of Heterologous Cells via Hemifusion T2 - 51st Annual Meeting of the Biophysical Society AN - 40663703; 4580651 JF - 51st Annual Meeting of the Biophysical Society AU - Leikina, Evgenia AU - Podbilewicz, Benjamin AU - Sapir, Amir Sapir AU - Valansi, Clari AU - Suissa, Meital AU - Shemer, Gidi AU - Chernomordik, Leonid Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Membrane fusion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40663703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=C.+elegans+EFF-1+Mediates+Homotypic+Fusion+of+Heterologous+Cells+via+Hemifusion&rft.au=Leikina%2C+Evgenia%3BPodbilewicz%2C+Benjamin%3BSapir%2C+Amir+Sapir%3BValansi%2C+Clari%3BSuissa%2C+Meital%3BShemer%2C+Gidi%3BChernomordik%2C+Leonid&rft.aulast=Leikina&rft.aufirst=Evgenia&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Catalytic Cycle of ATP Hydrolysis by P-Glycoprotein (ABCB1): The E.S Reaction Intermediate with Occluded ATP-γ-S Shows a High-Affinity to Low Affinity Switch at the Transport Substrate Site T2 - 51st Annual Meeting of the Biophysical Society AN - 40663201; 4580742 JF - 51st Annual Meeting of the Biophysical Society AU - Sauna, Zuben E AU - Nandigama, Krishnamachary AU - Anbudkar, Suresh V Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Hydrolysis KW - Affinity KW - P-Glycoprotein KW - ATP KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40663201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Catalytic+Cycle+of+ATP+Hydrolysis+by+P-Glycoprotein+%28ABCB1%29%3A+The+E.S+Reaction+Intermediate+with+Occluded+ATP-%26amp%3Bgamma%3B-S+Shows+a+High-Affinity+to+Low+Affinity+Switch+at+the+Transport+Substrate+Site&rft.au=Sauna%2C+Zuben+E%3BNandigama%2C+Krishnamachary%3BAnbudkar%2C+Suresh+V&rft.aulast=Sauna&rft.aufirst=Zuben&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Simultaneous Imaging of NAD+ and NADH using CARS and 2-Photon Fluorescence Microscopy T2 - 51st Annual Meeting of the Biophysical Society AN - 40663154; 4580369 JF - 51st Annual Meeting of the Biophysical Society AU - Rosales, Tilman AU - Xu, Jianhua AU - Smirnov, Aleksandr V AU - Combs, Christian AU - Davenport, Lesley AU - Knutson, Jay R Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Fluorescence microscopy KW - Imaging techniques KW - NADH KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40663154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Simultaneous+Imaging+of+NAD%2B+and+NADH+using+CARS+and+2-Photon+Fluorescence+Microscopy&rft.au=Rosales%2C+Tilman%3BXu%2C+Jianhua%3BSmirnov%2C+Aleksandr+V%3BCombs%2C+Christian%3BDavenport%2C+Lesley%3BKnutson%2C+Jay+R&rft.aulast=Rosales&rft.aufirst=Tilman&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nuclear Envelope Assembly by Fusion between Nuclear Membrane Vesicles and Protein-Free Liposomes. T2 - 51st Annual Meeting of the Biophysical Society AN - 40662979; 4580660 JF - 51st Annual Meeting of the Biophysical Society AU - Rafikova, Elvira R AU - Melikov, Kamran AU - Ramos, Corinne AU - Chernomordik, Leonid V Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Nuclear membranes KW - Membrane vesicles KW - Membrane fusion KW - Liposomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40662979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Nuclear+Envelope+Assembly+by+Fusion+between+Nuclear+Membrane+Vesicles+and+Protein-Free+Liposomes.&rft.au=Rafikova%2C+Elvira+R%3BMelikov%2C+Kamran%3BRamos%2C+Corinne%3BChernomordik%2C+Leonid+V&rft.aulast=Rafikova&rft.aufirst=Elvira&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Aldose Reductase Studied by Comparative Analysis of Neutron Scattering, X-Ray Ultra-High Resolution and QM Electron Density Maps and Molecular Dynamics T2 - 51st Annual Meeting of the Biophysical Society AN - 40662543; 4580489 JF - 51st Annual Meeting of the Biophysical Society AU - Cachau, Raul E AU - Podjarny, Alberto D AU - Ruiz, Federico AU - Ventura, Oscar N AU - Burt, Stanley K Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Aldehyde reductase KW - Maps KW - Neutron scattering KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40662543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Aldose+Reductase+Studied+by+Comparative+Analysis+of+Neutron+Scattering%2C+X-Ray+Ultra-High+Resolution+and+QM+Electron+Density+Maps+and+Molecular+Dynamics&rft.au=Cachau%2C+Raul+E%3BPodjarny%2C+Alberto+D%3BRuiz%2C+Federico%3BVentura%2C+Oscar+N%3BBurt%2C+Stanley+K&rft.aulast=Cachau&rft.aufirst=Raul&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cryo-Electron Tomography of E.coli: Structure and Functional Analysis of Chemotaxis Receptor Assemblies T2 - 51st Annual Meeting of the Biophysical Society AN - 40661861; 4579357 JF - 51st Annual Meeting of the Biophysical Society AU - Khursigara, Cezar M AU - Zhang, Peijun AU - Lefman, Jonathan AU - Hartnell, Lisa M AU - Subramaniam, Sriram Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Functional analysis KW - Tomography KW - Chemotaxis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40661861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Cryo-Electron+Tomography+of+E.coli%3A+Structure+and+Functional+Analysis+of+Chemotaxis+Receptor+Assemblies&rft.au=Khursigara%2C+Cezar+M%3BZhang%2C+Peijun%3BLefman%2C+Jonathan%3BHartnell%2C+Lisa+M%3BSubramaniam%2C+Sriram&rft.aulast=Khursigara&rft.aufirst=Cezar&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biodiversity in Z Bands of Superfast Muscles T2 - 51st Annual Meeting of the Biophysical Society AN - 40661624; 4579705 JF - 51st Annual Meeting of the Biophysical Society AU - Nahirney, Patrick C AU - Wang, Kuan Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Biological diversity KW - Muscles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40661624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Biodiversity+in+Z+Bands+of+Superfast+Muscles&rft.au=Nahirney%2C+Patrick+C%3BWang%2C+Kuan&rft.aulast=Nahirney&rft.aufirst=Patrick&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inactivation of Enveloped Viruses with Preservation of Structural Integrity by Hydrophobic Alkylating Compounds. T2 - 51st Annual Meeting of the Biophysical Society AN - 40661123; 4579874 JF - 51st Annual Meeting of the Biophysical Society AU - Raviv, Yossef AU - Blumenthal, Robert AU - Viard, Mathias Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Inactivation KW - Viruses KW - Preservation KW - Hydrophobicity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40661123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Inactivation+of+Enveloped+Viruses+with+Preservation+of+Structural+Integrity+by+Hydrophobic+Alkylating+Compounds.&rft.au=Raviv%2C+Yossef%3BBlumenthal%2C+Robert%3BViard%2C+Mathias&rft.aulast=Raviv&rft.aufirst=Yossef&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effects of Membrane Composition on the Activation Energy of Thermal Denaturation of Rhodopsin T2 - 51st Annual Meeting of the Biophysical Society AN - 40660886; 4579810 JF - 51st Annual Meeting of the Biophysical Society AU - Bennett, Michael P AU - Mitchell, Drake C Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Membranes KW - Rhodopsin KW - Thermal denaturation KW - Membrane composition KW - Temperature effects KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40660886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=The+Effects+of+Membrane+Composition+on+the+Activation+Energy+of+Thermal+Denaturation+of+Rhodopsin&rft.au=Bennett%2C+Michael+P%3BMitchell%2C+Drake+C&rft.aulast=Bennett&rft.aufirst=Michael&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Macromolecular Crowding on the Rate of Refolding of Carbonic Anhydrase T2 - 51st Annual Meeting of the Biophysical Society AN - 40660852; 4579802 JF - 51st Annual Meeting of the Biophysical Society AU - Monterroso, Begona AU - McPhie, Peter AU - Minton, Allen P Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Crowding KW - Carbonic anhydrase KW - Macromolecules KW - Stocking density KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40660852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Effect+of+Macromolecular+Crowding+on+the+Rate+of+Refolding+of+Carbonic+Anhydrase&rft.au=Monterroso%2C+Begona%3BMcPhie%2C+Peter%3BMinton%2C+Allen+P&rft.aulast=Monterroso&rft.aufirst=Begona&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Remodeling of Human Ca@@dv@1.2 Calcium Channels in Atherosclerosis T2 - 51st Annual Meeting of the Biophysical Society AN - 40660459; 4580241 JF - 51st Annual Meeting of the Biophysical Society AU - Tiwari, Swasti AU - Zhang, Yuwei AU - Heller, Jennifer AU - Abernethy, Darrell R AU - Soldatov, Nikolai M Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Calcium channels KW - Calcium channels (voltage-gated) KW - Arteriosclerosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40660459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Remodeling+of+Human+Ca%40%40dv%401.2+Calcium+Channels+in+Atherosclerosis&rft.au=Tiwari%2C+Swasti%3BZhang%2C+Yuwei%3BHeller%2C+Jennifer%3BAbernethy%2C+Darrell+R%3BSoldatov%2C+Nikolai+M&rft.aulast=Tiwari&rft.aufirst=Swasti&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Femtosecond Fluorescence Dynamics of Tryptophan in Anabaena and E. coli Thioredoxins T2 - 51st Annual Meeting of the Biophysical Society AN - 40660304; 4579694 JF - 51st Annual Meeting of the Biophysical Society AU - Xu, Jianhua AU - Gleason, Florence K AU - Toptygin, Dmitri AU - Callis, Patrik R AU - Brand, Ludwig AU - Knutson, Jay R Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Fluorescence KW - Tryptophan KW - Thioredoxin KW - Escherichia coli KW - Anabaena KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40660304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Femtosecond+Fluorescence+Dynamics+of+Tryptophan+in+Anabaena+and+E.+coli+Thioredoxins&rft.au=Xu%2C+Jianhua%3BGleason%2C+Florence+K%3BToptygin%2C+Dmitri%3BCallis%2C+Patrik+R%3BBrand%2C+Ludwig%3BKnutson%2C+Jay+R&rft.aulast=Xu&rft.aufirst=Jianhua&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Crystal Structure and Receptor-Binding Site of the Adhesin CfaE of Enterotoxigenic Escherichia coli CFA/I Fimbriae T2 - 51st Annual Meeting of the Biophysical Society AN - 40660243; 4579840 JF - 51st Annual Meeting of the Biophysical Society AU - Li, Yong-Fu AU - Poole, Steven AU - Rasulova, Fatima AU - Savarino, Stephen J AU - Xia, Di Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Pili KW - Adhesins KW - Crystal structure KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40660243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Crystal+Structure+and+Receptor-Binding+Site+of+the+Adhesin+CfaE+of+Enterotoxigenic+Escherichia+coli+CFA%2FI+Fimbriae&rft.au=Li%2C+Yong-Fu%3BPoole%2C+Steven%3BRasulova%2C+Fatima%3BSavarino%2C+Stephen+J%3BXia%2C+Di&rft.aulast=Li&rft.aufirst=Yong-Fu&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - AFM Structures of a Potential Malaria Vaccine Component: Escherichia coli Derived Plasmodium falciparum Merozoite Surface Protein 3 T2 - 51st Annual Meeting of the Biophysical Society AN - 40660187; 4579832 JF - 51st Annual Meeting of the Biophysical Society AU - Kotova, Svetlana AU - Smith, Paul D AU - Lebowitz, Jack AU - Narum, David L AU - Jin, Albert J Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Vaccines KW - Malaria KW - Merozoites KW - Disease control KW - Escherichia coli KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40660187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=AFM+Structures+of+a+Potential+Malaria+Vaccine+Component%3A+Escherichia+coli+Derived+Plasmodium+falciparum+Merozoite+Surface+Protein+3&rft.au=Kotova%2C+Svetlana%3BSmith%2C+Paul+D%3BLebowitz%2C+Jack%3BNarum%2C+David+L%3BJin%2C+Albert+J&rft.aulast=Kotova&rft.aufirst=Svetlana&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Membrane Interactions of N-[8-(2-Hydroxybenzoyl)Amino] Caprylate T2 - 51st Annual Meeting of the Biophysical Society AN - 40660090; 4580623 JF - 51st Annual Meeting of the Biophysical Society AU - Polozov, Ivan V AU - Gawrisch, Klaus Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Membranes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40660090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Membrane+Interactions+of+N-%5B8-%282-Hydroxybenzoyl%29Amino%5D+Caprylate&rft.au=Polozov%2C+Ivan+V%3BGawrisch%2C+Klaus&rft.aulast=Polozov&rft.aufirst=Ivan&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High Affinity Antagonists of the Plasmodial Surface Anion Channel Inhibit Nutrient Acquisition by Intraerythrocytic Malaria Parasites. T2 - 51st Annual Meeting of the Biophysical Society AN - 40660002; 4580778 JF - 51st Annual Meeting of the Biophysical Society AU - Pillai, Ajay D AU - Solomon, Tsione AU - Pain, Margaret AU - Desai, Sanjay A Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Parasites KW - Anion channels KW - Malaria KW - Affinity KW - Nutrients KW - Antagonists KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40660002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=High+Affinity+Antagonists+of+the+Plasmodial+Surface+Anion+Channel+Inhibit+Nutrient+Acquisition+by+Intraerythrocytic+Malaria+Parasites.&rft.au=Pillai%2C+Ajay+D%3BSolomon%2C+Tsione%3BPain%2C+Margaret%3BDesai%2C+Sanjay+A&rft.aulast=Pillai&rft.aufirst=Ajay&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selective Fluorophore-Assisted Light Inactivation of Voltage-Gated Calcium Channels T2 - 51st Annual Meeting of the Biophysical Society AN - 40659944; 4580107 JF - 51st Annual Meeting of the Biophysical Society AU - Kobrinsky, E AU - Lee, J H AU - Soldatov, N M Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Channels KW - Inactivation KW - Calcium channels (voltage-gated) KW - Light effects KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40659944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Selective+Fluorophore-Assisted+Light+Inactivation+of+Voltage-Gated+Calcium+Channels&rft.au=Kobrinsky%2C+E%3BLee%2C+J+H%3BSoldatov%2C+N+M&rft.aulast=Kobrinsky&rft.aufirst=E&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Overlap and Multi-Orientation SH3 Ligand Motifs Enhance Signaling Capacity of Proline-Rich Domains of Signaling Proteins T2 - 51st Annual Meeting of the Biophysical Society AN - 40659912; 4580442 JF - 51st Annual Meeting of the Biophysical Society AU - Ma, Kan AU - Forbes, Jeffrey G AU - Gutierrez-Cruz, Gustavo AU - Wang, Kuan Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Signal transduction KW - Ligands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40659912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Novel+Overlap+and+Multi-Orientation+SH3+Ligand+Motifs+Enhance+Signaling+Capacity+of+Proline-Rich+Domains+of+Signaling+Proteins&rft.au=Ma%2C+Kan%3BForbes%2C+Jeffrey+G%3BGutierrez-Cruz%2C+Gustavo%3BWang%2C+Kuan&rft.aulast=Ma&rft.aufirst=Kan&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Protein Crystal Growth in a Simulated Microgravity Environment T2 - 51st Annual Meeting of the Biophysical Society AN - 40659817; 4580401 JF - 51st Annual Meeting of the Biophysical Society AU - Cachau, Raul E AU - Sanjoh, Akira Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Microgravity KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40659817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Protein+Crystal+Growth+in+a+Simulated+Microgravity+Environment&rft.au=Cachau%2C+Raul+E%3BSanjoh%2C+Akira&rft.aulast=Cachau&rft.aufirst=Raul&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - b-Adrenegric Stimulation of Transgenic Mouse Overexpressing the Exon-22 Isoform of the Human Cav1.2a1C Channel Enhanced Development of Cardiomyopathy as Revealed by MRI Imaging T2 - 51st Annual Meeting of the Biophysical Society AN - 40659805; 4579760 JF - 51st Annual Meeting of the Biophysical Society AU - Asemu, G AU - Fishbein, K W AU - Canuto, H C AU - Spencer, R G S AU - Abernethy, D R AU - Soldatov, N M Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Channels KW - Magnetic resonance imaging KW - Cardiomyopathy KW - Calcium channels (voltage-gated) KW - Transgenic mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40659805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=b-Adrenegric+Stimulation+of+Transgenic+Mouse+Overexpressing+the+Exon-22+Isoform+of+the+Human+Cav1.2a1C+Channel+Enhanced+Development+of+Cardiomyopathy+as+Revealed+by+MRI+Imaging&rft.au=Asemu%2C+G%3BFishbein%2C+K+W%3BCanuto%2C+H+C%3BSpencer%2C+R+G+S%3BAbernethy%2C+D+R%3BSoldatov%2C+N+M&rft.aulast=Asemu&rft.aufirst=G&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Targeting of Nanofusion Machines to Cells T2 - 51st Annual Meeting of the Biophysical Society AN - 40659745; 4579339 JF - 51st Annual Meeting of the Biophysical Society AU - Jacobs, Amy AU - Blumenthal, Robert Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Nanotechnology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40659745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Targeting+of+Nanofusion+Machines+to+Cells&rft.au=Jacobs%2C+Amy%3BBlumenthal%2C+Robert&rft.aulast=Jacobs&rft.aufirst=Amy&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Tyr-53 Mutations on Polymerization of Dictyostelium Actin and Cell Phenotype T2 - 51st Annual Meeting of the Biophysical Society AN - 40659531; 4580293 JF - 51st Annual Meeting of the Biophysical Society AU - Liu, Xiong AU - Shu, Shi AU - Korn, Edward D Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Mutation KW - Actin KW - Polymerization KW - Phenotypes KW - Dictyostelium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40659531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Effects+of+Tyr-53+Mutations+on+Polymerization+of+Dictyostelium+Actin+and+Cell+Phenotype&rft.au=Liu%2C+Xiong%3BShu%2C+Shi%3BKorn%2C+Edward+D&rft.aulast=Liu&rft.aufirst=Xiong&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytoskeleton Reorganization and Syncytium Formation T2 - 51st Annual Meeting of the Biophysical Society AN - 40659076; 4580649 JF - 51st Annual Meeting of the Biophysical Society AU - Richard, Jean-Philippe AU - Leikina, Evgenia AU - Chernomordik, Leonid Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Cytoskeleton KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40659076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Cytoskeleton+Reorganization+and+Syncytium+Formation&rft.au=Richard%2C+Jean-Philippe%3BLeikina%2C+Evgenia%3BChernomordik%2C+Leonid&rft.aulast=Richard&rft.aufirst=Jean-Philippe&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differences in Hydration Coupled to Specific and Competitive BamHI-DNA Binding T2 - 51st Annual Meeting of the Biophysical Society AN - 40659029; 4580587 JF - 51st Annual Meeting of the Biophysical Society AU - Sidorova, Nina Y AU - Muradymov, Shakir AU - Rau, Donald C Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Hydration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40659029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Differences+in+Hydration+Coupled+to+Specific+and+Competitive+BamHI-DNA+Binding&rft.au=Sidorova%2C+Nina+Y%3BMuradymov%2C+Shakir%3BRau%2C+Donald+C&rft.aulast=Sidorova&rft.aufirst=Nina&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Restricted Lateral Mobility of Raft- Associated CD4 Results in Inhibition of HIV-1 Envelope Glycoprotein Mediated Fusion T2 - 51st Annual Meeting of the Biophysical Society AN - 40659008; 4580655 JF - 51st Annual Meeting of the Biophysical Society AU - Puri, Anu AU - Rawat, Satinder S AU - Zimmerman, Christina AU - Johnson, Benitra T AU - Cho, Edward AU - Lockett, Stephen J AU - Blumenthal, Robert Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Glycoproteins KW - Mobility KW - Envelopes KW - CD4 antigen KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40659008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Restricted+Lateral+Mobility+of+Raft-+Associated+CD4+Results+in+Inhibition+of+HIV-1+Envelope+Glycoprotein+Mediated+Fusion&rft.au=Puri%2C+Anu%3BRawat%2C+Satinder+S%3BZimmerman%2C+Christina%3BJohnson%2C+Benitra+T%3BCho%2C+Edward%3BLockett%2C+Stephen+J%3BBlumenthal%2C+Robert&rft.aulast=Puri&rft.aufirst=Anu&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enhanced Elastic Network Model for tRNA Folding T2 - 51st Annual Meeting of the Biophysical Society AN - 40658788; 4580566 JF - 51st Annual Meeting of the Biophysical Society AU - Hastings, Whitney A AU - Jeong, Jay I AU - Chirikjian, Gregory S AU - Shapiro, Bruce A Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - TRNA KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40658788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Enhanced+Elastic+Network+Model+for+tRNA+Folding&rft.au=Hastings%2C+Whitney+A%3BJeong%2C+Jay+I%3BChirikjian%2C+Gregory+S%3BShapiro%2C+Bruce+A&rft.aulast=Hastings&rft.aufirst=Whitney&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Towards an Ultra-High Resolution Macromolecular Structural Database: Analysis of Proton Acidities and Peptide Bond Deformations by QM Calculations, Neutron Scattering and X-Ray Crystallography Studies. T2 - 51st Annual Meeting of the Biophysical Society AN - 40658784; 4579829 JF - 51st Annual Meeting of the Biophysical Society AU - Cachau, Raul E AU - Duque-Norena, Mario A AU - Niimura, Nobuo AU - Burt, Stanley K Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Deformation KW - Acidity KW - Protons KW - Databases KW - Macromolecules KW - X-ray crystallography KW - Neutron scattering KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40658784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Towards+an+Ultra-High+Resolution+Macromolecular+Structural+Database%3A+Analysis+of+Proton+Acidities+and+Peptide+Bond+Deformations+by+QM+Calculations%2C+Neutron+Scattering+and+X-Ray+Crystallography+Studies.&rft.au=Cachau%2C+Raul+E%3BDuque-Norena%2C+Mario+A%3BNiimura%2C+Nobuo%3BBurt%2C+Stanley+K&rft.aulast=Cachau&rft.aufirst=Raul&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Influence of Membrane Alterations on the Inhibition of K@@dv@ Channels by Voltage Sensor Toxins T2 - 51st Annual Meeting of the Biophysical Society AN - 40658746; 4580879 JF - 51st Annual Meeting of the Biophysical Society AU - Milescu, Mirela AU - Swartz, Kenton J Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Channels KW - Membranes KW - Toxins KW - Sensors KW - Potassium channels (voltage-gated) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40658746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Influence+of+Membrane+Alterations+on+the+Inhibition+of+K%40%40dv%40+Channels+by+Voltage+Sensor+Toxins&rft.au=Milescu%2C+Mirela%3BSwartz%2C+Kenton+J&rft.aulast=Milescu&rft.aufirst=Mirela&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural Basis for Specific p53 Binding-Induced DNA Bending T2 - 51st Annual Meeting of the Biophysical Society AN - 40658724; 4580595 JF - 51st Annual Meeting of the Biophysical Society AU - Pan, Yongping AU - Nussinov, Ruth Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - P53 protein KW - Deformation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40658724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Structural+Basis+for+Specific+p53+Binding-Induced+DNA+Bending&rft.au=Pan%2C+Yongping%3BNussinov%2C+Ruth&rft.aulast=Pan&rft.aufirst=Yongping&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Why does Nature Want to Avoid Isoleucine in Protein-Protein Interactions: A Hypothesis. T2 - 51st Annual Meeting of the Biophysical Society AN - 40658437; 4580528 JF - 51st Annual Meeting of the Biophysical Society AU - Ma, Buyong AU - Nussinov, Ruth Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Protein interaction KW - Isoleucine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40658437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Why+does+Nature+Want+to+Avoid+Isoleucine+in+Protein-Protein+Interactions%3A+A+Hypothesis.&rft.au=Ma%2C+Buyong%3BNussinov%2C+Ruth&rft.aulast=Ma&rft.aufirst=Buyong&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Crystallization of the Recombinant N-Terminal Domain of Copper Transport ATPase CopB from Thermophilic Bacteria Archaeoglobus Fulgidus T2 - 51st Annual Meeting of the Biophysical Society AN - 40658346; 4580307 JF - 51st Annual Meeting of the Biophysical Society AU - Ma, Jichun AU - Xia, Di Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Copper KW - Thermophilic bacteria KW - Crystallization KW - Adenosinetriphosphatase KW - Recombinants KW - Archaeoglobus fulgidus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40658346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Crystallization+of+the+Recombinant+N-Terminal+Domain+of+Copper+Transport+ATPase+CopB+from+Thermophilic+Bacteria+Archaeoglobus+Fulgidus&rft.au=Ma%2C+Jichun%3BXia%2C+Di&rft.aulast=Ma&rft.aufirst=Jichun&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Influence of a Potassium Channel Voltage Sensor Toxin on the Structure of Lipid Membranes T2 - 51st Annual Meeting of the Biophysical Society AN - 40658306; 4580875 JF - 51st Annual Meeting of the Biophysical Society AU - Krepkiy, Dmitriy AU - Mihailescu, Ella AU - Gawrisch, Klaus AU - Swartz, Kenton J Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Potassium channels KW - Lipid membranes KW - Toxins KW - Sensors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40658306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Influence+of+a+Potassium+Channel+Voltage+Sensor+Toxin+on+the+Structure+of+Lipid+Membranes&rft.au=Krepkiy%2C+Dmitriy%3BMihailescu%2C+Ella%3BGawrisch%2C+Klaus%3BSwartz%2C+Kenton+J&rft.aulast=Krepkiy&rft.aufirst=Dmitriy&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - θ-Defensin Retrocyclin-2 Promotes Endocytosis T2 - 51st Annual Meeting of the Biophysical Society AN - 40658195; 4580038 JF - 51st Annual Meeting of the Biophysical Society AU - Melikov, Kamran AU - Leikina, Eugenia AU - Gabrielian, Anna AU - Lehrer, Robert I AU - Chernomordik, Leonid V Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Endocytosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40658195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=%26amp%3Btheta%3B-Defensin+Retrocyclin-2+Promotes+Endocytosis&rft.au=Melikov%2C+Kamran%3BLeikina%2C+Eugenia%3BGabrielian%2C+Anna%3BLehrer%2C+Robert+I%3BChernomordik%2C+Leonid+V&rft.aulast=Melikov&rft.aufirst=Kamran&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural Changes in Guanylate Kinase Studied by Neutron Scattering and Osmotic Stress T2 - 51st Annual Meeting of the Biophysical Society AN - 40658101; 4579805 JF - 51st Annual Meeting of the Biophysical Society AU - Stanley, Christopher B AU - Krueger, Susan AU - Parsegian, V Adrian AU - Rau, Donald C Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Stress KW - Guanylate kinase KW - Osmotic stress KW - Neutron scattering KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40658101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Structural+Changes+in+Guanylate+Kinase+Studied+by+Neutron+Scattering+and+Osmotic+Stress&rft.au=Stanley%2C+Christopher+B%3BKrueger%2C+Susan%3BParsegian%2C+V+Adrian%3BRau%2C+Donald+C&rft.aulast=Stanley&rft.aufirst=Christopher&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preconditioning Increases S-Nitrosylation of L-Type Calcium Channel and SERCA2a T2 - 51st Annual Meeting of the Biophysical Society AN - 40657812; 4579944 JF - 51st Annual Meeting of the Biophysical Society AU - Sun, Junhui AU - Steenbergen, Charles AU - Murphy, Elizabeth Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Channels KW - Calcium channels (L-type) KW - Ca@@u2+@-transporting ATPase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40657812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Preconditioning+Increases+S-Nitrosylation+of+L-Type+Calcium+Channel+and+SERCA2a&rft.au=Sun%2C+Junhui%3BSteenbergen%2C+Charles%3BMurphy%2C+Elizabeth&rft.aulast=Sun&rft.aufirst=Junhui&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single-Molecule Probe of Solute-Specific Water Release Upon Association of Adamantane with Cyclodextrin T2 - 51st Annual Meeting of the Biophysical Society AN - 40657530; 4579806 JF - 51st Annual Meeting of the Biophysical Society AU - Gurnev, Philip AU - Harries, Daniel AU - Parsegian, Adrian AU - Bezrukov, Sergey Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Probes KW - Cyclodextrin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40657530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Single-Molecule+Probe+of+Solute-Specific+Water+Release+Upon+Association+of+Adamantane+with+Cyclodextrin&rft.au=Gurnev%2C+Philip%3BHarries%2C+Daniel%3BParsegian%2C+Adrian%3BBezrukov%2C+Sergey&rft.aulast=Gurnev&rft.aufirst=Philip&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vibrational Infrared Spectroscopic Studies of Model Biomembranes: Characterization of Lipid Raft Formation T2 - 51st Annual Meeting of the Biophysical Society AN - 40656649; 4579922 JF - 51st Annual Meeting of the Biophysical Society AU - Schultz, Zachary D AU - Crane, Nicole J AU - Levin, Ira W Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Lipid rafts KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40656649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Vibrational+Infrared+Spectroscopic+Studies+of+Model+Biomembranes%3A+Characterization+of+Lipid+Raft+Formation&rft.au=Schultz%2C+Zachary+D%3BCrane%2C+Nicole+J%3BLevin%2C+Ira+W&rft.aulast=Schultz&rft.aufirst=Zachary&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Position of Fluorescein on Oligonucleotide Affects the Apparent Affinity of Transcription Factor Binding T2 - 51st Annual Meeting of the Biophysical Society AN - 40656568; 4579893 JF - 51st Annual Meeting of the Biophysical Society AU - Stephen, Andrew G AU - Rishi, Vikas AU - Hagan, Nathan A AU - Fabris, Daniele AU - Vinson, Charles AU - Shoemaker, Robert H AU - Fisher, Robert J Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Affinity KW - Fluorescein KW - Oligonucleotides KW - Transcription factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40656568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=The+Position+of+Fluorescein+on+Oligonucleotide+Affects+the+Apparent+Affinity+of+Transcription+Factor+Binding&rft.au=Stephen%2C+Andrew+G%3BRishi%2C+Vikas%3BHagan%2C+Nathan+A%3BFabris%2C+Daniele%3BVinson%2C+Charles%3BShoemaker%2C+Robert+H%3BFisher%2C+Robert+J&rft.aulast=Stephen&rft.aufirst=Andrew&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Extremely Long Polyunsaturated Acyl Chains on Receptor Activation and Membrane Properties T2 - 51st Annual Meeting of the Biophysical Society AN - 40656376; 4579556 JF - 51st Annual Meeting of the Biophysical Society AU - Mitchell, Drake C AU - Niu, Shui-Lin AU - Bennett, Michael AU - Hines, Kirk G AU - Greeley, Laura A AU - Andersen, Brian M Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Membranes KW - Receptor mechanisms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40656376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Effects+of+Extremely+Long+Polyunsaturated+Acyl+Chains+on+Receptor+Activation+and+Membrane+Properties&rft.au=Mitchell%2C+Drake+C%3BNiu%2C+Shui-Lin%3BBennett%2C+Michael%3BHines%2C+Kirk+G%3BGreeley%2C+Laura+A%3BAndersen%2C+Brian+M&rft.aulast=Mitchell&rft.aufirst=Drake&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Probing the Structures of Coated Vesicles by Cryo-Electron Tomography T2 - 51st Annual Meeting of the Biophysical Society AN - 40656075; 4579353 JF - 51st Annual Meeting of the Biophysical Society AU - Heymann, J Bernard AU - Winkler, Dennis C AU - Yim, Yang-In AU - Eisenberg, Evan AU - Greene, Lois E AU - Steven, Alasdair C Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Coated vesicles KW - Tomography KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40656075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Probing+the+Structures+of+Coated+Vesicles+by+Cryo-Electron+Tomography&rft.au=Heymann%2C+J+Bernard%3BWinkler%2C+Dennis+C%3BYim%2C+Yang-In%3BEisenberg%2C+Evan%3BGreene%2C+Lois+E%3BSteven%2C+Alasdair+C&rft.aulast=Heymann&rft.aufirst=J&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Protein-Protein Docking with the EMAP Program of CHARMM: A Map and Grid Based Approach T2 - 51st Annual Meeting of the Biophysical Society AN - 40655931; 4579683 JF - 51st Annual Meeting of the Biophysical Society AU - Gruschus, James M AU - Wu, Xiongwu AU - Brooks, Bernard R Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Berthing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40655931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Protein-Protein+Docking+with+the+EMAP+Program+of+CHARMM%3A+A+Map+and+Grid+Based+Approach&rft.au=Gruschus%2C+James+M%3BWu%2C+Xiongwu%3BBrooks%2C+Bernard+R&rft.aulast=Gruschus&rft.aufirst=James&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Backbone Relaxation Triggered by the Ionization of Internal Groups in Proteins: A Self-Guided Langevin Dynamics Study T2 - 51st Annual Meeting of the Biophysical Society AN - 40655926; 4579538 JF - 51st Annual Meeting of the Biophysical Society AU - Damjanovic, Ana AU - Wu, Xiongwu AU - Brooks, Bernard AU - Bertrand, Garcia-Moreno E Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Ionization KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40655926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Backbone+Relaxation+Triggered+by+the+Ionization+of+Internal+Groups+in+Proteins%3A+A+Self-Guided+Langevin+Dynamics+Study&rft.au=Damjanovic%2C+Ana%3BWu%2C+Xiongwu%3BBrooks%2C+Bernard%3BBertrand%2C+Garcia-Moreno+E&rft.aulast=Damjanovic&rft.aufirst=Ana&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Is the Chloride Conductance of Glutamate Transporters Evolutionarily Conserved? T2 - 51st Annual Meeting of the Biophysical Society AN - 40655260; 4579598 JF - 51st Annual Meeting of the Biophysical Society AU - Ryan, Renae M AU - Mindell, Joseph A Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Chloride KW - Evolution KW - Glutamic acid transporter KW - Chloride conductance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40655260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Is+the+Chloride+Conductance+of+Glutamate+Transporters+Evolutionarily+Conserved%3F&rft.au=Ryan%2C+Renae+M%3BMindell%2C+Joseph+A&rft.aulast=Ryan&rft.aufirst=Renae&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exploring the Structural Stability and the Mechanism of Dissociation of Alzheimer's Amyloid Fibrils T2 - 51st Annual Meeting of the Biophysical Society AN - 40655126; 4579540 JF - 51st Annual Meeting of the Biophysical Society AU - Buchete, Nicolae-Viorel AU - Hummer, Gerhard Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Amyloid KW - Fibrils KW - Dissociation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40655126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Exploring+the+Structural+Stability+and+the+Mechanism+of+Dissociation+of+Alzheimer%27s+Amyloid+Fibrils&rft.au=Buchete%2C+Nicolae-Viorel%3BHummer%2C+Gerhard&rft.aulast=Buchete&rft.aufirst=Nicolae-Viorel&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Small Angle Neutron Scattering Studies of Clathrin Triskelia in Solution Show Evidence of Molecular Flexibility T2 - 51st Annual Meeting of the Biophysical Society AN - 40654791; 4580033 JF - 51st Annual Meeting of the Biophysical Society AU - Ferguson, Matthew L AU - Prasad, Kondury AU - Boukari, Hacene AU - Sackett, Dan L AU - Krueger, Susan AU - Lafer, Eileen M AU - Nossal, Ralph Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Clathrin KW - Neutron scattering KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40654791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Small+Angle+Neutron+Scattering+Studies+of+Clathrin+Triskelia+in+Solution+Show+Evidence+of+Molecular+Flexibility&rft.au=Ferguson%2C+Matthew+L%3BPrasad%2C+Kondury%3BBoukari%2C+Hacene%3BSackett%2C+Dan+L%3BKrueger%2C+Susan%3BLafer%2C+Eileen+M%3BNossal%2C+Ralph&rft.aulast=Ferguson&rft.aufirst=Matthew&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Role of RNA Editing in the Na@@u+@/Ca@@u2+@ Exchanger from the Squid Loligo pealeii. T2 - 51st Annual Meeting of the Biophysical Society AN - 40654595; 4579945 JF - 51st Annual Meeting of the Biophysical Society AU - Palma, Francisco AU - Rosenthal, Joshua AU - Holmgren, Miguel Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Na@u+/Ca@@u2+@-exchanging ATPase KW - RNA editing KW - Calcium KW - Loligo pealeii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40654595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Functional+Role+of+RNA+Editing+in+the+Na%40%40u%2B%40%2FCa%40%40u2%2B%40+Exchanger+from+the+Squid+Loligo+pealeii.&rft.au=Palma%2C+Francisco%3BRosenthal%2C+Joshua%3BHolmgren%2C+Miguel&rft.aulast=Palma&rft.aufirst=Francisco&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Membrane Neck Dynamics during Normal and Aborted Endocytic Events Revealed by Patch Clamp Admittance T2 - 51st Annual Meeting of the Biophysical Society AN - 40654364; 4580037 JF - 51st Annual Meeting of the Biophysical Society AU - Lizunov, Vladimir A AU - Kirchhausen, Tom AU - Frolov, Vadim AU - Zimmerberg, Joshua Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Membranes KW - Neck KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40654364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Membrane+Neck+Dynamics+during+Normal+and+Aborted+Endocytic+Events+Revealed+by+Patch+Clamp+Admittance&rft.au=Lizunov%2C+Vladimir+A%3BKirchhausen%2C+Tom%3BFrolov%2C+Vadim%3BZimmerberg%2C+Joshua&rft.aulast=Lizunov&rft.aufirst=Vladimir&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exo70 Subunit of Exocyst Complex is not Required for Tethering and Fusion of GLUT4 Vesicles in Rat Adipose Cells T2 - 51st Annual Meeting of the Biophysical Society AN - 40654300; 4580031 JF - 51st Annual Meeting of the Biophysical Society AU - Lizunov, Vladimir A AU - Lisinski, Ivonne AU - Zimmerberg, Joshua AU - Cushman, Samuel W Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Vesicle fusion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40654300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Exo70+Subunit+of+Exocyst+Complex+is+not+Required+for+Tethering+and+Fusion+of+GLUT4+Vesicles+in+Rat+Adipose+Cells&rft.au=Lizunov%2C+Vladimir+A%3BLisinski%2C+Ivonne%3BZimmerberg%2C+Joshua%3BCushman%2C+Samuel+W&rft.aulast=Lizunov&rft.aufirst=Vladimir&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nonmuscle Myosin II Scaffolding Properties but not Motor Activity are Necessary to Prevent Hydrocephalus in the Developing Brain T2 - 51st Annual Meeting of the Biophysical Society AN - 40653889; 4579528 JF - 51st Annual Meeting of the Biophysical Society AU - Ma, Xuefei AU - Bao, Jianjun AU - Adelstein, Robert S Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Brain KW - Myosin KW - Hydrocephalus KW - Motor activity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40653889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Nonmuscle+Myosin+II+Scaffolding+Properties+but+not+Motor+Activity+are+Necessary+to+Prevent+Hydrocephalus+in+the+Developing+Brain&rft.au=Ma%2C+Xuefei%3BBao%2C+Jianjun%3BAdelstein%2C+Robert+S&rft.aulast=Ma&rft.aufirst=Xuefei&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nebulin Elasticity and Unfolding of Transient a-Helices: A Stretched Protein Ruler Pre-Loads Thin Filaments of the Skeletal Muscle. T2 - 51st Annual Meeting of the Biophysical Society AN - 40651451; 4579607 JF - 51st Annual Meeting of the Biophysical Society AU - Yadavalli, Vamsi K AU - Forbes, Jeffrey G AU - Cruz, Gustavo G AU - Wang, Kuan Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Skeletal muscle KW - Filaments KW - Elasticity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40651451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Nebulin+Elasticity+and+Unfolding+of+Transient+a-Helices%3A+A+Stretched+Protein+Ruler+Pre-Loads+Thin+Filaments+of+the+Skeletal+Muscle.&rft.au=Yadavalli%2C+Vamsi+K%3BForbes%2C+Jeffrey+G%3BCruz%2C+Gustavo+G%3BWang%2C+Kuan&rft.aulast=Yadavalli&rft.aufirst=Vamsi&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytosolic Surface of Outer Hair Cells Plasma Membrane: Search of Membrane Motor by Atomic Force Microscopy T2 - 51st Annual Meeting of the Biophysical Society AN - 40651421; 4579603 JF - 51st Annual Meeting of the Biophysical Society AU - Sinha, Ghanshyam AU - Sabri, Firozeh AU - Dimitriadis, Emilios AU - Iwasa, Kuni Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Plasma membranes KW - Hair KW - Atomic force microscopy KW - Outer hair cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40651421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Cytosolic+Surface+of+Outer+Hair+Cells+Plasma+Membrane%3A+Search+of+Membrane+Motor+by+Atomic+Force+Microscopy&rft.au=Sinha%2C+Ghanshyam%3BSabri%2C+Firozeh%3BDimitriadis%2C+Emilios%3BIwasa%2C+Kuni&rft.aulast=Sinha&rft.aufirst=Ghanshyam&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pharmacophore Modeling of Stereoselective Inhibitor Binding Site of the Human Organic Cation Transporter, hOCT1 T2 - 51st Annual Meeting of the Biophysical Society AN - 40651283; 4579933 JF - 51st Annual Meeting of the Biophysical Society AU - Ravichandran, Sarangan AU - Moaddel, R AU - Bigi, F AU - Collins, Jack R AU - Yamaguchi, R AU - Wainer, Irving W Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Cations KW - Organic cation transporter KW - Pharmacophores KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40651283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=Pharmacophore+Modeling+of+Stereoselective+Inhibitor+Binding+Site+of+the+Human+Organic+Cation+Transporter%2C+hOCT1&rft.au=Ravichandran%2C+Sarangan%3BMoaddel%2C+R%3BBigi%2C+F%3BCollins%2C+Jack+R%3BYamaguchi%2C+R%3BWainer%2C+Irving+W&rft.aulast=Ravichandran&rft.aufirst=Sarangan&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - b2-Subunit Facilitation of the Cav1.2 Calcium Channel Current Involves Two Independent Determinants T2 - 51st Annual Meeting of the Biophysical Society AN - 40650990; 4579627 JF - 51st Annual Meeting of the Biophysical Society AU - Lao, Qi Zong AU - Kobrinsky, Evgeny AU - Harry, Jo Beth AU - Ravindran, Arippa AU - Soldatov, Nikolai M Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Calcium channels KW - Calcium channels (voltage-gated) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40650990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=51st+Annual+Meeting+of+the+Biophysical+Society&rft.atitle=b2-Subunit+Facilitation+of+the+Cav1.2+Calcium+Channel+Current+Involves+Two+Independent+Determinants&rft.au=Lao%2C+Qi+Zong%3BKobrinsky%2C+Evgeny%3BHarry%2C+Jo+Beth%3BRavindran%2C+Arippa%3BSoldatov%2C+Nikolai+M&rft.aulast=Lao&rft.aufirst=Qi&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=51st+Annual+Meeting+of+the+Biophysical+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={B65ED1CE-3D1E-400B-BEC0-4 29A5DA15800} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Influence of CD25+ Regulatory T Cells on Th1 Immunity T2 - 2007 Keystone Symposia on Immunologic Memory (C4) AN - 40545113; 4528192 JF - 2007 Keystone Symposia on Immunologic Memory (C4) AU - Belkaid, Yasmine Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Lymphocytes T KW - Immunoregulation KW - CD25 antigen KW - Helper cells KW - Immunity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40545113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Immunologic+Memory+%28C4%29&rft.atitle=Influence+of+CD25%2B+Regulatory+T+Cells+on+Th1+Immunity&rft.au=Belkaid%2C+Yasmine&rft.aulast=Belkaid&rft.aufirst=Yasmine&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Immunologic+Memory+%28C4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 4&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Aging and the Immune System: Discoveries and Challenges T2 - 2007 Keystone Symposia on Immunologic Memory (C4) AN - 40544686; 4528193 JF - 2007 Keystone Symposia on Immunologic Memory (C4) AU - Hodes, Richard Joel Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Immune system KW - Aging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40544686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Immunologic+Memory+%28C4%29&rft.atitle=Aging+and+the+Immune+System%3A+Discoveries+and+Challenges&rft.au=Hodes%2C+Richard+Joel&rft.aulast=Hodes&rft.aufirst=Richard&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Immunologic+Memory+%28C4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 4&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Public Clonotype Usage in Virus-Specific CD8+ T Cell Populations: Mechanisms of TCR Sharing and Biological Implications T2 - 2007 Keystone Symposia on Immunologic Memory (C4) AN - 40543293; 4528155 JF - 2007 Keystone Symposia on Immunologic Memory (C4) AU - Price, David A Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - T-cell receptor KW - CD8 antigen KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40543293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Immunologic+Memory+%28C4%29&rft.atitle=Public+Clonotype+Usage+in+Virus-Specific+CD8%2B+T+Cell+Populations%3A+Mechanisms+of+TCR+Sharing+and+Biological+Implications&rft.au=Price%2C+David+A&rft.aulast=Price&rft.aufirst=David&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Immunologic+Memory+%28C4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 4&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prime-Boost Vaccination Against HIV Infection T2 - 2007 Keystone Symposia on Immunologic Memory (C4) AN - 40541946; 4528207 JF - 2007 Keystone Symposia on Immunologic Memory (C4) AU - Koup, Richard A Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 KW - Infection KW - Vaccination KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40541946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Immunologic+Memory+%28C4%29&rft.atitle=Prime-Boost+Vaccination+Against+HIV+Infection&rft.au=Koup%2C+Richard+A&rft.aulast=Koup&rft.aufirst=Richard&rft.date=2007-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Immunologic+Memory+%28C4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 4&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Folic acid supplements and risk of facial clefts: national population based case-control study AN - 20724030; 7314564 AB - OBJECTIVE: To explore the role of folic acid supplements, dietary folates, and multivitamins in the prevention of facial clefts. Design National population based case-control study. Setting Infants born 1996-2001 in Norway. Participants 377 infants with cleft lip with or without cleft palate; 196 infants with cleft palate alone; 763 controls. MAIN OUTCOME MEASURES: Association of facial clefts with maternal intake of folic acid supplements, multivitamins, and folates in diet. RESULTS: Folic acid supplementation during early pregnancy ( greater than or equal to 400 mu g/day) was associated with a reduced risk of isolated cleft lip with or without cleft palate after adjustment for multivitamins, smoking, and other potential confounding factors (adjusted odds ratio 0.61, 95% confidence interval 0.39 to 0.96). Independent of supplements, diets rich in fruits, vegetables, and other high folate containing foods reduced the risk somewhat (adjusted odds ratio 0.75, 0.50 to 1.11). The lowest risk of cleft lip was among women with folate rich diets who also took folic acid supplements and multivitamins (0.36, 0.17 to 0.77). Folic acid provided no protection against cleft palate alone (1.07, 0.56 to 2.03). CONCLUSIONS: Folic acid supplements during early pregnancy seem to reduce the risk of isolated cleft lip (with or without cleft palate) by about a third. Other vitamins and dietary factors may provide additional benefit. JF - British Medical Journal AU - Wilcox, Allen J AU - Lie, Rolv Terje AU - Solvoll, Kari AU - Taylor, Jack AU - McConnaughey, D Robert AU - Aabyholm, Frank AU - Vindenes, Hallvard AU - Vollset, Stein Emil AU - Drevon, Christian A AD - Epidemiology Branch, National Institute of Environmental Health Sciences/NIH, Durham, NC 27709, USA Y1 - 2007/03/03/ PY - 2007 DA - 2007 Mar 03 SP - 464 PB - British Medical Association, BMA House Square Tavistock Square London WC1H 9JP UK, [mailto:info.web@bma.org.uk], [URL:http://www.bma.org.uk/] VL - 334 IS - 7591 SN - 0959-8138, 0959-8138 KW - Risk Abstracts KW - folic acid KW - Diets KW - risk reduction KW - Smoking KW - vitamins KW - fruits KW - prevention KW - Norway KW - Infants KW - Pregnancy KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20724030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Medical+Journal&rft.atitle=Folic+acid+supplements+and+risk+of+facial+clefts%3A+national+population+based+case-control+study&rft.au=Wilcox%2C+Allen+J%3BLie%2C+Rolv+Terje%3BSolvoll%2C+Kari%3BTaylor%2C+Jack%3BMcConnaughey%2C+D+Robert%3BAabyholm%2C+Frank%3BVindenes%2C+Hallvard%3BVollset%2C+Stein+Emil%3BDrevon%2C+Christian+A&rft.aulast=Wilcox&rft.aufirst=Allen&rft.date=2007-03-03&rft.volume=334&rft.issue=7591&rft.spage=464&rft.isbn=&rft.btitle=&rft.title=British+Medical+Journal&rft.issn=09598138&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diets; folic acid; Smoking; risk reduction; vitamins; fruits; prevention; Pregnancy; Infants; Norway ER - TY - JOUR T1 - Relationships between locomotor activation and alterations in brain temperature during selective blockade and stimulation of dopamine transmission. AN - 69011713; 17196751 AB - It is well known that the dopamine (DA) system plays an essential role in the organization and regulation of brain activational processes. Various environmental stimuli that induce locomotor activation also increase DA transmission, while DA antagonists decrease spontaneous locomotion. Our previous work supports close relationships between locomotor activation and brain and body temperature increases induced by salient environmental challenges or occurring during motivated behavior. While this correlation was also true for psychomotor stimulant drugs such as methamphetamine and MDMA, more complex relationships or even inverted correlations were found for other drugs that are known to increase DA transmission (i.e. heroin and cocaine). In the present study we examined brain, muscle and skin temperatures together with conventional locomotion during selective interruption of DA transmission induced by a mixture of D1 and D2 antagonists (SCH-23390 and eticlopride at 0.2 mg/kg, s.c.) and its selective activation by apomorphine (APO; 0.05 and 0.25 mg/kg, i.v.) in rats. While full DA receptor blockade decreased spontaneous locomotion, it significantly increased brain, muscle and skin temperatures, suggesting metabolic brain activation under conditions of vasodilatation (or weakening of normal vascular tone). In contrast, APO strongly decreased skin temperature but tended to decrease brain and muscle temperatures despite strong hyperlocomotion and stereotypy. The brain temperature response to APO was strongly dependent on basal brain temperature, with hypothermia at high basal temperatures and weak hyperthermia at low temperatures. While supporting the role of DA in locomotor activation, these data suggest more complex relationships between drug-induced alterations in DA transmission, behavioral activation and metabolic brain activation. JF - Neuroscience AU - Brown, P L AU - Bae, D AU - Kiyatkin, E A AD - Cellular Neurobiology Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, DHHS, 333 Cassell Drive, Baltimore, MD 21224, USA. Y1 - 2007/03/02/ PY - 2007 DA - 2007 Mar 02 SP - 335 EP - 343 VL - 145 IS - 1 SN - 0306-4522, 0306-4522 KW - Benzazepines KW - 0 KW - Dopamine Agonists KW - Dopamine Antagonists KW - Salicylamides KW - eticlopride KW - J8M468HBH4 KW - Apomorphine KW - N21FAR7B4S KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Animals KW - Drug Interactions KW - Benzazepines -- pharmacology KW - Analysis of Variance KW - Rats, Long-Evans KW - Dopamine Agonists -- pharmacology KW - Dopamine Antagonists -- pharmacology KW - Apomorphine -- pharmacology KW - Salicylamides -- pharmacology KW - Male KW - Behavior, Animal KW - Body Temperature -- drug effects KW - Brain -- drug effects KW - Dopamine -- metabolism KW - Body Temperature -- physiology KW - Motor Activity -- physiology KW - Motor Activity -- drug effects KW - Brain -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69011713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Relationships+between+locomotor+activation+and+alterations+in+brain+temperature+during+selective+blockade+and+stimulation+of+dopamine+transmission.&rft.au=Brown%2C+P+L%3BBae%2C+D%3BKiyatkin%2C+E+A&rft.aulast=Brown&rft.aufirst=P&rft.date=2007-03-02&rft.volume=145&rft.issue=1&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-15 N1 - Date created - 2007-02-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Trends Neurosci. 2000 Oct;23(10 Suppl):S57-63 [11052221] Brain Res. 1999 Jul 24;835(2):154-61 [10415370] J Appl Physiol (1985). 2002 Jun;92(6):2667-79 [12015388] Eur J Neurosci. 2002 Jul;16(1):164-8 [12153543] Behav Brain Res. 2002 Dec 2;137(1-2):27-46 [12445714] Neuroscience. 2003;116(2):525-38 [12559108] J Neurosci. 2003 May 1;23(9):3924-9 [12736362] Neuroscience. 2003;121(4):991-8 [14580949] Neuroreport. 2003 Dec 19;14(18):2429-32 [14663205] Eur J Neurosci. 2004 Jul;20(1):51-8 [15245478] Farmakol Toksikol. 1968 Sep-Oct;31(5):563-7 [5707725] Eur J Pharmacol. 1973 Jul;23(1):82-9 [4270157] Psychopharmacologia. 1974 Apr 23;36(3):189-202 [4152540] Life Sci. 1985 May 20;36(20):1983-94 [3990520] Brain Res. 1985 Dec 9;358(1-2):110-21 [2866815] Eur J Pharmacol. 1987 Jan 20;133(3):243-7 [2951265] J Appl Physiol. 1963 Mar;18:367-70 [13932993] Curr Opin Pharmacol. 2005 Feb;5(1):34-41 [15661623] Physiol Behav. 2005 Mar 31;84(4):563-70 [15811391] Eur J Neurosci. 2005 Aug;22(4):930-8 [16115216] Psychopharmacology (Berl). 2005 Sep;181(2):299-308 [15778873] Brain Res Brain Res Rev. 2005 Dec 1;50(1):27-56 [15890410] Eur J Neurosci. 2006 Sep;24(5):1385-94 [16987223] J Pharm Pharmacol. 1972 Sep;24(9):702-5 [4404073] Br J Pharmacol. 1975 May;54(1):123-4 [1139073] Am J Physiol. 1976 Feb;230(2):449-55 [816208] Psychopharmacology (Berl). 1978 Jul 19;58(3):289-96 [98800] J Physiol. 1978 Sep;282:471-83 [214547] Can J Physiol Pharmacol. 1979 May;57(5):469-75 [466574] Annu Rev Neurosci. 1978;1:129-69 [756202] J Physiol. 1980 Mar;300:7-17 [7381796] Am J Physiol. 1982 May;242(5):R471-81 [7081473] Neuropharmacology. 1984 May;23(5):483-9 [6738824] J Neurosci. 1985 Feb;5(2):297-306 [2857776] Psychol Rev. 1987 Oct;94(4):469-92 [3317472] Pharmacol Biochem Behav. 1989 Jan;32(1):43-7 [2499893] Physiol Rev. 1991 Jan;71(1):155-234 [1986388] Naunyn Schmiedebergs Arch Pharmacol. 1992 Nov;346(5):504-10 [1470222] Arch Int Pharmacodyn Ther. 1993 Jul-Aug;324:17-32 [7905255] Pharmacol Ther. 1994;64(2):291-370 [7878079] Brain Res. 1995 Jan 30;670(2):205-14 [7743187] J Neurophysiol. 1996 Jan;75(1):142-53 [8822548] Neuroscience. 1996 Nov;75(1):13-8 [8923518] J Neurosci. 1997 Aug 1;17(15):5697-710 [9221769] J Neurosci. 1997 Aug 1;17(15):5972-8 [9221793] J Neurosci. 1999 May 1;19(9):3594-609 [10212318] J Neurosci. 2002 Feb 1;22(3):1072-80 [11826136] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hematopoietic Stem Cell Donation in Children: A Review of the Sibling Donor Experience AN - 61409821; 200705186 AB - Hematopoietic Stem Cell Transplant (HSCT) represents the second most frequent major organ transplant in the United States. Compared with other family members, siblings are more likely to be immunologically matched with the recipient and therefore are often the most suitable donors. Due to a dearth of information on the positive and adverse effects of HSCT on pediatric sibling donors, we sought to examine available data. Eight published reports assessing the pediatric sibling donor experience were identified in the literature. Studies were predominately small (n < 44) and cross-sectional. Results suggest a range of psychological distress responses with higher distress in pediatric donor than non-donor siblings. Recommendations include future longitudinal research on sibling donor psychosocial adjustment, identification of sibling donors at high risk for maladaptive responses, and development of educational and psychosocial interventions for this overlooked pediatric population. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Journal of Psychosocial Oncology AU - Wiener, Lori S AU - Steffen-Smith, Emilie AU - Fry, Terry AU - Wayne, Alan S AD - ACSW, Coordinator, Pediatric Psychosocial Support and Research Program, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, 20892 email: wienerl@mail.nih.gov Y1 - 2007/03/02/ PY - 2007 DA - 2007 Mar 02 SP - 45 EP - 66 PB - Haworth Press, Binghamton NY VL - 25 IS - 1 SN - 0734-7332, 0734-7332 KW - Psychological Distress KW - United States of America KW - Health Care Services KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61409821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychosocial+Oncology&rft.atitle=Hematopoietic+Stem+Cell+Donation+in+Children%3A+A+Review+of+the+Sibling+Donor+Experience&rft.au=Wiener%2C+Lori+S%3BSteffen-Smith%2C+Emilie%3BFry%2C+Terry%3BWayne%2C+Alan+S&rft.aulast=Wiener&rft.aufirst=Lori&rft.date=2007-03-02&rft.volume=25&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychosocial+Oncology&rft.issn=07347332&rft_id=info:doi/10.1300%2FJ077v25n01_03 LA - English DB - Social Services Abstracts N1 - Date revised - 2007-12-10 N1 - Number of references - 47 N1 - Last updated - 2016-09-28 N1 - CODEN - JPONED N1 - SubjectsTermNotLitGenreText - Health Care Services; United States of America; Psychological Distress DO - http://dx.doi.org/10.1300/J077v25n01_03 ER - TY - CPAPER T1 - STAT3-Ser727: Integrator of Stem Cell Niche Survival Signals T2 - 2007 Keystone Symposia on Stem Cell Interactions with their Microenvironmental Niche (X1) AN - 40547591; 4530572 JF - 2007 Keystone Symposia on Stem Cell Interactions with their Microenvironmental Niche (X1) AU - Androutsellis-Theotokis, Andreas Y1 - 2007/03/02/ PY - 2007 DA - 2007 Mar 02 KW - Stem cells KW - Niches KW - Survival KW - Cell survival KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40547591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Stem+Cell+Interactions+with+their+Microenvironmental+Niche+%28X1%29&rft.atitle=STAT3-Ser727%3A+Integrator+of+Stem+Cell+Niche+Survival+Signals&rft.au=Androutsellis-Theotokis%2C+Andreas&rft.aulast=Androutsellis-Theotokis&rft.aufirst=Andreas&rft.date=2007-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Stem+Cell+Interactions+with+their+Microenvironmental+Niche+%28X1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=82 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Negative Regulation of Stem Cell Self-Renewal and Osteoblast Formation T2 - 2007 Keystone Symposia on Stem Cell Interactions with their Microenvironmental Niche (X1) AN - 40545186; 4530594 JF - 2007 Keystone Symposia on Stem Cell Interactions with their Microenvironmental Niche (X1) AU - Kasai, Masataka Y1 - 2007/03/02/ PY - 2007 DA - 2007 Mar 02 KW - Stem cells KW - Osteoblasts KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40545186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Stem+Cell+Interactions+with+their+Microenvironmental+Niche+%28X1%29&rft.atitle=Negative+Regulation+of+Stem+Cell+Self-Renewal+and+Osteoblast+Formation&rft.au=Kasai%2C+Masataka&rft.aulast=Kasai&rft.aufirst=Masataka&rft.date=2007-03-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Stem+Cell+Interactions+with+their+Microenvironmental+Niche+%28X1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=82 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Are There Long-Term Effects of Early Child Care? AN - 920081464; 2011061252 JF - Child Development AU - Belsky, Jay AU - Vandell, Deborah Lowe AU - Burchinal, Margaret AU - Clarke-Stewart, K Allison AU - McCartney, Kathleen AU - Owen, Margaret Tresch AU - NICHD Early Child Care Research Network AD - NICHD Early Child Care Research Network PY - 2007 SP - 681 EP - 701 VL - 78 IS - 2 SN - 0009-3920, 0009-3920 KW - language KW - psycholinguistics KW - development of language KW - lexical development KW - childcare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/920081464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amlaib&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+Development&rft.atitle=Are+There+Long-Term+Effects+of+Early+Child+Care%3F&rft.au=Belsky%2C+Jay%3BVandell%2C+Deborah+Lowe%3BBurchinal%2C+Margaret%3BClarke-Stewart%2C+K+Allison%3BMcCartney%2C+Kathleen%3BOwen%2C+Margaret+Tresch%3BNICHD+Early+Child+Care+Research+Network&rft.aulast=Belsky&rft.aufirst=Jay&rft.date=2007-03-01&rft.volume=78&rft.issue=2&rft.spage=681&rft.isbn=&rft.btitle=&rft.title=Child+Development&rft.issn=00093920&rft_id=info:doi/10.1111%2Fj.1467-8624.2007.01021.x LA - English DB - MLA International Bibliography N1 - Update - 201101 N1 - SuppNotes - English summary. N1 - Last updated - 2017-01-04 DO - http://dx.doi.org/10.1111/j.1467-8624.2007.01021.x ER - TY - JOUR T1 - Who Participates in the Criminal Justice Drug Abuse Treatment Studies (CJ-DATS)? AN - 877592540; 13643619 AB - The national Criminal Justice Drug Abuse Treatment Studies (CJ-DATS) is a multisite research program to improve outcomes for offenders with drug problems who are reentering the community after incarceration. Baseline data from three ongoing CJ-DATS studies were pooled to examine the characteristics of study participants. These analyses suggest that CJ-DATS study participants have serious drug problems, criminal histories, and mental health problems that can decrease the likelihood of successful community reentry unless addressed. HIV-risk behavior was associated with several categories of criminal acts, suggesting that the relationship between sexual risk behaviors and crime may need further investigation. JF - Prison Journal AU - Fletcher, Bennett W AU - Lehman, Wayne EK AU - Wexler, Harry K AU - Melnick, Gerald AD - National Institute on Drug Abuse, Bethesda, MD Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 25 EP - 57 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 87 IS - 1 SN - 0032-8855, 0032-8855 KW - Risk Abstracts KW - judicial system KW - sexual behavior KW - Historical account KW - Drug abuse KW - prisons KW - Human immunodeficiency virus KW - crime KW - Drugs KW - mental disorders KW - Research programs KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/877592540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Prison+Journal&rft.atitle=Who+Participates+in+the+Criminal+Justice+Drug+Abuse+Treatment+Studies+%28CJ-DATS%29%3F&rft.au=Fletcher%2C+Bennett+W%3BLehman%2C+Wayne+EK%3BWexler%2C+Harry+K%3BMelnick%2C+Gerald&rft.aulast=Fletcher&rft.aufirst=Bennett&rft.date=2007-03-01&rft.volume=87&rft.issue=1&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Prison+Journal&rft.issn=00328855&rft_id=info:doi/10.1177%2F0032885506299037 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - judicial system; prisons; Historical account; sexual behavior; crime; Drug abuse; mental disorders; Drugs; Research programs; Human immunodeficiency virus DO - http://dx.doi.org/10.1177/0032885506299037 ER - TY - JOUR T1 - Degradation of indulin, a kraft pine lignin, by Serratia marcescens AN - 856764804; 13897104 AB - Serratia marcescens isolated from decaying coconut pith exhibited high lignolytic activity. Growth on indicator medium, analysis of residual indulin, and infra-red spectroscopic analysis indicated the lignolytic potential of the isolate. Ortho-Coumaric acid, ferulic acid, 2,3-dihydroxy cinnamic acid and protocatechuic acid were identified as intermediates involved in indulin degradation by S. marcescens. Qualitative confirmation and quantitative estimation of the intermediates were carried out by high performance thin layer chromatography (HPTLC). JF - Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants and Agricultural Wastes AU - Manangeeswaran, Mohanraj AU - Ramalingam, Vijayanandraj V AU - Kumar, Karthik AU - Mohan, Natarajan AD - Centre for advanced studies in Botany, University of Madras, Chennai, India,United States Food and Drug Administration, National Institutes of Health, Bethesda, Washington, D.C., USA Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 321 EP - 327 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 42 IS - 3 SN - 0360-1234, 0360-1234 KW - Environment Abstracts; Water Resources Abstracts KW - Indulin degradation KW - Lignolytic activity KW - Lignin degrading bacteria KW - Serratia marcescens KW - Degradation KW - Chromatography KW - Agricultural wastes KW - Indicators KW - Serratia KW - Agricultural Chemicals KW - Pollutants KW - Acids KW - Pesticides KW - Farm Wastes KW - Thin Layer Chromatography KW - SW 3050:Ultimate disposal of wastes KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/856764804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Science+and+Health%2C+Part+B%3A+Pesticides%2C+Food+Contaminants+and+Agricultural+Wastes&rft.atitle=Degradation+of+indulin%2C+a+kraft+pine+lignin%2C+by+Serratia+marcescens&rft.au=Manangeeswaran%2C+Mohanraj%3BRamalingam%2C+Vijayanandraj+V%3BKumar%2C+Karthik%3BMohan%2C+Natarajan&rft.aulast=Manangeeswaran&rft.aufirst=Mohanraj&rft.date=2007-03-01&rft.volume=42&rft.issue=3&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Science+and+Health%2C+Part+B%3A+Pesticides%2C+Food+Contaminants+and+Agricultural+Wastes&rft.issn=03601234&rft_id=info:doi/10.1080%2F03601230701229320 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-03-01 N1 - Number of references - 32 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Degradation; Chromatography; Agricultural wastes; Pesticides; Serratia; Agricultural Chemicals; Pollutants; Acids; Indicators; Farm Wastes; Thin Layer Chromatography; Serratia marcescens DO - http://dx.doi.org/10.1080/03601230701229320 ER - TY - JOUR T1 - Representing object colour in language comprehension AN - 85663499; 200801227 AB - Embodied theories of cognition hold that mentally representing something red engages the neural subsystems that respond to environmental perception of that colour. This paper examines whether implicit perceptual information on object colour is represented during sentence comprehension even though doing so does not necessarily facilitate task performance. After reading a sentence that implied a particular colour for a given object, participants were presented with a picture of the object that either matched or mismatched the implied colour. When asked if the pictured object was mentioned in the preceding sentence, people's responses were faster when the colours mismatched than when they matched, suggesting that object colour is represented differently to other object properties such as shape and orientation. A distinction between stable and unstable embodied representations is proposed to allow embodied theories to account for these findings. [Copyright 2006 Elsevier B.V.] JF - Cognition AU - Connell, Louise AD - Cognition & Communication Research Centre, Division of Psychology, Northumbria University, Newcastle upon Tyne, NEI 8ST, UK Tel: + 44 191 227 3446, Fax: +44 191 227 4515 louise.connell@northumbria.ac.uk Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 476 EP - 485 VL - 102 IS - 3 SN - 0010-0277, 0010-0277 KW - Cognitive Processes (12950) KW - Mental Representation (52945) KW - Color (13450) KW - Visual Media (94550) KW - Visual Perception (94600) KW - Comprehension (13950) KW - Brain (09350) KW - Embodiment (21558) KW - Reading Processes (71150) KW - article KW - 4012: psycholinguistics; language and cognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85663499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cognition&rft.atitle=Representing+object+colour+in+language+comprehension&rft.au=Connell%2C+Louise&rft.aulast=Connell&rft.aufirst=Louise&rft.date=2007-03-01&rft.volume=102&rft.issue=3&rft.spage=476&rft.isbn=&rft.btitle=&rft.title=Cognition&rft.issn=00100277&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2008-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - CGTNAU N1 - SubjectsTermNotLitGenreText - Color (13450); Embodiment (21558); Cognitive Processes (12950); Mental Representation (52945); Brain (09350); Reading Processes (71150); Visual Perception (94600); Visual Media (94550); Comprehension (13950) ER - TY - JOUR T1 - Histopathological and lymphangiogenic parameters in relation to lymph node metastasis in early stage oral squamous cell carcinoma. AN - 85398445; pmid-17307596 AB - Lymph node metastasis from oral squamous cell carcinoma (SCC) correlates with a poor prognosis. Therefore, accurate assessment of lymph node status is crucial in treatment planning. Furthermore, prediction of delayed neck metastasis (DNM), especially in early stage tumors with a clinically negative (N0) neck, will determine the need for neck dissection or irradiation. In this study, we assess various clinical, histopathological and lymphangiogenic parameters in early stage oral SCC and their association with DNM.Clinical, histological, and immunohistochemical analyses were undertaken for 29 patients with T1N0M0 or T2N0M0 oral SCC affecting the tongue or floor of mouth and correlated with the development of DNM.Tumor thickness, nuclear pleomorphism, pattern of invasion, and immunohistochemical expression of the lymphangiogenesis-associated molecules VEGFR-3 and VEGF-C were associated with DNM.Analysis of these parameters may help to identify patients who would benefit from a neck dissection or irradiation by predicting the likelihood of lymph node metastasis. JF - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons AU - Warburton, Gary AU - Nikitakis, Nikolaos G AU - Roberson, Patrick AU - Marinos, Nancy J AU - Wu, Tianxia AU - Sauk, John J AU - Ord, Robert A AU - Wahl, Sharon M AD - Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-4532, USA. Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 475 EP - 484 VL - 65 IS - 3 SN - 0278-2391, 0278-2391 KW - National Library of Medicine KW - Adult KW - Aged KW - Aged, 80 and over KW - Carcinoma, Squamous Cell: metabolism KW - *Carcinoma, Squamous Cell: pathology KW - Female KW - Humans KW - Immunoenzyme Techniques KW - Lymphangiogenesis: physiology KW - *Lymphatic Metastasis: diagnosis KW - Male KW - Middle Aged KW - Mouth Neoplasms: metabolism KW - *Mouth Neoplasms: pathology KW - Neoplasm Staging KW - Prognosis KW - ROC Curve KW - Regression Analysis KW - Retrospective Studies KW - Sensitivity and Specificity KW - Vascular Endothelial Growth Factor C: analysis KW - Vascular Endothelial Growth Factor C: biosynthesis KW - Vascular Endothelial Growth Factor D: analysis KW - Vascular Endothelial Growth Factor D: biosynthesis KW - Vascular Endothelial Growth Factor Receptor-3: analysis KW - *Vascular Endothelial Growth Factor Receptor-3: biosynthesis KW - Vascular Endothelial Growth Factors: analysis KW - *Vascular Endothelial Growth Factors: biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85398445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+oral+and+maxillofacial+surgery+%3A+official+journal+of+the+American+Association+of+Oral+and+Maxillofacial+Surgeons&rft.atitle=Histopathological+and+lymphangiogenic+parameters+in+relation+to+lymph+node+metastasis+in+early+stage+oral+squamous+cell+carcinoma.&rft.au=Warburton%2C+Gary%3BNikitakis%2C+Nikolaos+G%3BRoberson%2C+Patrick%3BMarinos%2C+Nancy+J%3BWu%2C+Tianxia%3BSauk%2C+John+J%3BOrd%2C+Robert+A%3BWahl%2C+Sharon+M&rft.aulast=Warburton&rft.aufirst=Gary&rft.date=2007-03-01&rft.volume=65&rft.issue=3&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=Journal+of+oral+and+maxillofacial+surgery+%3A+official+journal+of+the+American+Association+of+Oral+and+Maxillofacial+Surgeons&rft.issn=02782391&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Risk of Psychoactive Substance Dependence Among Substance Users in a Trauma Inpatient Population AN - 755132920; 13623922 AB - One measure of a substance's addictive risk is the proportion of users who become dependent. This study evaluates the lifetime and current risk of substance dependence among lifetime substance users among trauma inpatients and provides a relative ranking of addictive risk among the substances. Data on use of 8 substance groups (alcohol, opiates, cannabis, cocaine's other stimulants, sedative-hypnotics, hallucinogens, other drugs) were obtained by interview (Structured Clinical Interview for the DSM-III-R) from 1,118 adult trauma inpatients. Prevalence of lifetime dependence among lifetime users ranged from 80.7% for opiates and 70.9% for cocaine to 33.3% for hallucinogens and 26.6% for sedative-hypnotics. The rank order of addictive risk was similar to that found in the general population. Trauma inpatients had a higher absolute addictive risk than the general population, comparable to the risk found in patients in treatment for substance use disorders, suggesting the importance of screening trauma inpatients for substance dependence. JF - Journal of Addictive Diseases AU - Martins, Silvia S AU - Copersino, Marc L AU - Soderstrom, Carl A AU - Smith, Gordon S AU - Dischinger, Patricia C AU - McDuff, David R AU - Hebel, JRichard AU - Kerns, Timothy J AU - Ho, Shiu M AU - Read, Kathleen M AU - Gorelick, David A AD - Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 SP - 71 EP - 77 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 26 IS - 1 SN - 1055-0887, 1055-0887 KW - Risk Abstracts KW - Alcohol KW - cocaine KW - substance use KW - Cannabis KW - Drugs KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/755132920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Addictive+Diseases&rft.atitle=Risk+of+Psychoactive+Substance+Dependence+Among+Substance+Users+in+a+Trauma+Inpatient+Population&rft.au=Martins%2C+Silvia+S%3BCopersino%2C+Marc+L%3BSoderstrom%2C+Carl+A%3BSmith%2C+Gordon+S%3BDischinger%2C+Patricia+C%3BMcDuff%2C+David+R%3BHebel%2C+JRichard%3BKerns%2C+Timothy+J%3BHo%2C+Shiu+M%3BRead%2C+Kathleen+M%3BGorelick%2C+David+A&rft.aulast=Martins&rft.aufirst=Silvia&rft.date=2007-03-01&rft.volume=26&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Journal+of+Addictive+Diseases&rft.issn=10550887&rft_id=info:doi/10.1300%2FJ069v26n01_09 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Alcohol; substance use; cocaine; Drugs; Cannabis DO - http://dx.doi.org/10.1300/J069v26n01_09 ER - TY - JOUR T1 - Clinico-Pathological and Prognostic Significance of p53, Bcl-2 and Her-2/neu Protein Markers in Colorectal Cancer Using Tissue Microarray. AN - 733743683; 18839030 AB - The prognostic role of her-2/neu has been established in breast cancer but remains controversial in colorectal cancer (CRC). Widespread genetic mutations in colorectal carcinogenesis exist on chromosome 17. Her- 2/neu gene and the tumor suppressor gene p53 are both located on this chromosome. Bcl-2 protein prolongs survival of a variety of cells by blocking apoptosis. The aim of this study is to evaluate the relationship between the overexpression of p53, bcl-2 and her-2/neu protein markers and the clinico-pathologic characteristics of CRC, and their influence on survival rates. One hundred and four cases of CRC had paraffin blocks with representative tissue, and sufficient follow-up data. They were arrayed and evaluated for protein marker expression using tissue microarray (TMA). Ten (9.6%), 35 (33.7%) and 27 (26%) of the patients were her-2/neu, p53 and bcl-2 positive, respectively. None of the examined clinico-pathologic factors had a significant relation with her-2/neu overexpression. Patients with +ve bcl-2 had a significantly higher mean age (52.4-/+13.3years) compared to 45.4-/+14.4 years for bcl-2 negative patients, p=0.03. Positive p53 was overexpressed in 20/44 (45.5%), 6/17 (35%), 9/43 (21%) cases of the colon, recto-sigmoid, and rectal sites, respectively, p=0.05. For the whole population, p53 overexpression had a significantly lower disease-free survival (DFS). For patients with Dukes' stage B, overexpression of p53 protein had a significant reduced overall survival (OS) p=0.04, metastasis free survival (MFS) p=0.004, and DFS p=0.01 rates. Expression of bcl-2 had a significantly better MFS p=0.001, while her-2/neu overexpression worsened the OS rate significantly, p=0.04. This study recommends the application of TMA technique for its economic importance and reliable quick throughput. The results from this study also suggest that overexpression of p53, bcl-2, and her-2/neu protein markers appear to be useful in selecting a group of CRC patients with a worse prognosis and constitute potential candidates for adjuvant therapy. Key Words: Her-2/neu , p53 , Bcl-2 , Colorectal cancer , Tissue microarray , Prognostic factors. JF - Journal of the Egyptian National Cancer Institute AU - Ismail, Hoda M AU - El-Baradie, Manal AU - Moneer, Manar AU - Khorshid, Ola AU - Touny, Ahmed AD - The Department of Pathology,National Cancer Institute, Cairo University. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 3 EP - 14 VL - 19 IS - 1 SN - 1110-0362, 1110-0362 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733743683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Egyptian+National+Cancer+Institute&rft.atitle=Clinico-Pathological+and+Prognostic+Significance+of+p53%2C+Bcl-2+and+Her-2%2Fneu+Protein+Markers+in+Colorectal+Cancer+Using+Tissue+Microarray.&rft.au=Ismail%2C+Hoda+M%3BEl-Baradie%2C+Manal%3BMoneer%2C+Manar%3BKhorshid%2C+Ola%3BTouny%2C+Ahmed&rft.aulast=Ismail&rft.aufirst=Hoda&rft.date=2007-03-01&rft.volume=19&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Egyptian+National+Cancer+Institute&rft.issn=11100362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-05 N1 - Date created - 2008-10-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Human stem cells, chromatin, and tissue engineering: boosting relevancy in developmental toxicity testing. AN - 70610734; 17539011 AB - Risk assessment derives its confidence from toxicology research that is based on relevancy to human health. This article focuses on two highly topical areas of current scientific research, stem cells and chromatin biology, which present new avenues for preclinical and clinical applications, and the frontier role of tissue engineering and regeneration. Appreciating the utility and necessity of chromatin and human somatic stem cells as research tools and looking toward tissue engineering may close the uncertainty gaps between animal and human cross-species toxicology evaluations. The focus will be on developmental toxicology applications, but appropriate extrapolation to any other areas of toxicology can be made. We further provide background on basic biology of these three areas and examples of how early life exposure to known and potential environmental toxicants induce malformations, childhood and adult-onset diseases, through aberrant chromatin modification of critical gene expressions (acute lymphocyte leukemia, heavy-metal nickel and cadmium-associated defects, and reproductive tract malformations and carcinomas induced by the synthetic estrogen, diethylstilbestrol). (c) 2007 Wiley-Liss, Inc. JF - Birth defects research. Part C, Embryo today : reviews AU - Cho, Elizabeth AU - Li, Wan-Ju AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. chofertikh@hotmail.com Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 20 EP - 40 VL - 81 IS - 1 SN - 1542-975X, 1542-975X KW - Chromatin KW - 0 KW - Histones KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Humans KW - Histones -- metabolism KW - Aging KW - Toxicology -- methods KW - Mice KW - Gene Dosage KW - Developmental Biology -- methods KW - Stem Cells -- drug effects KW - Stem Cells -- cytology KW - Chromatin -- drug effects KW - Stem Cells -- metabolism KW - Tissue Engineering -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70610734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+defects+research.+Part+C%2C+Embryo+today+%3A+reviews&rft.atitle=Human+stem+cells%2C+chromatin%2C+and+tissue+engineering%3A+boosting+relevancy+in+developmental+toxicity+testing.&rft.au=Cho%2C+Elizabeth%3BLi%2C+Wan-Ju&rft.aulast=Cho&rft.aufirst=Elizabeth&rft.date=2007-03-01&rft.volume=81&rft.issue=1&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Birth+defects+research.+Part+C%2C+Embryo+today+%3A+reviews&rft.issn=1542975X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-03 N1 - Date created - 2007-06-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Spiritual/Religious experiences and in-treatment outcome in an inner-city program for heroin and cocaine dependence. AN - 70542586; 17523584 AB - Although spirituality is an integral component of some of the most popular approaches to substance abuse treatment, there is little empirical evidence for a causal relationship between spirituality and treatment success. In the present study, 169 (121 male) opiate- or cocaine-abusing treatment seekers completed the Index of Spiritual Experience (INSPIRIT), a questionnaire that assesses both spirituality and religiosity. Responses were analyzed in terms of demographic variables and in-treatment outcome, which was determined by treatment retention and drug screens from observed biweekly urine collections. Religious/spiritual beliefs were common in these participants and were associated with in-treatment outcome: total INSPIRIT score was weakly correlated (r = .16, p < .04) with number of subsequent cocaine-negative urines, and participants reporting that they frequently spent time on religious/spiritual activities showed significantly better outcomes in terms of subsequent drug use and treatment retention. Women and African Americans were more likely than men and non-African Americans to report religious and spiritual beliefs or experiences on several individual items, and African Americans had higher INSPIRIT scores than Caucasians. The results suggest that spiritual and religious experience plays a role in substance abuse recovery and that demographic characteristics should be considered in the design of spiritually oriented behavioral interventions for addiction. JF - Journal of psychoactive drugs AU - Heinz, Adrienne AU - Epstein, David H AU - Preston, Kenzie L AD - Clinical Pharmacology and Treatment Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA. aheinz3@uic.edu Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 41 EP - 49 VL - 39 IS - 1 SN - 0279-1072, 0279-1072 KW - Index Medicus KW - Sex Factors KW - Humans KW - Pilot Projects KW - Demography KW - Baltimore KW - Prospective Studies KW - African Americans -- psychology KW - Adult KW - Treatment Outcome KW - Surveys and Questionnaires KW - Middle Aged KW - Female KW - Male KW - Heroin Dependence -- ethnology KW - Substance Abuse Treatment Centers KW - Cocaine-Related Disorders -- ethnology KW - Religion KW - Cocaine-Related Disorders -- psychology KW - Spirituality KW - Heroin Dependence -- therapy KW - Health Knowledge, Attitudes, Practice KW - Cocaine-Related Disorders -- therapy KW - Heroin Dependence -- psychology KW - Urban Health Services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70542586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychoactive+drugs&rft.atitle=Spiritual%2FReligious+experiences+and+in-treatment+outcome+in+an+inner-city+program+for+heroin+and+cocaine+dependence.&rft.au=Heinz%2C+Adrienne%3BEpstein%2C+David+H%3BPreston%2C+Kenzie+L&rft.aulast=Heinz&rft.aufirst=Adrienne&rft.date=2007-03-01&rft.volume=39&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychoactive+drugs&rft.issn=02791072&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-14 N1 - Date created - 2007-05-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A possible role of thymidine phosphorylase expression and 5-fluorouracil increased sensitivity in oropharyngeal cancer patients. AN - 70469877; 17378915 AB - Thymidine Pi deoxyribosyltransferase (TP) is an enzyme involved in DNA synthesis up-regulated in tumours and it is also a pro-angiogenic factor. TP cannot activate capecitabine, because capecitabine first needs conversion by carboxylesterase and cytidine deaminase into 5-deoxy-fluorouridine. This compound can be activated by TP to 5-fluorouracil (5-FU). Although TP is not necessary for 5-FU toxicity, experimental data suggest that high levels of TP correlate with an enhanced response to 5-FU therapy. In this study, we have analysed by immunohistochemistry CD34, CD68 and TP positive cells in bioptic samples from 53 patients with T(1-3) N(0-1) M(0) oropharyngeal squamous cell carcinoma (OSC) and from 24 patients with non-dysplastic oropharyngeal leukoplakia (NDOLP). Results showed that the mean of TP-positive cells, CD68 positive macrophages and CD34 positive endothelial cells eval-uated as microvessel density (MVD) was significantly higher in OSC than in NDOLP. Moreover, at a median follow-up of 19 months, patients with TP expression and higher MVD showed a better survival rate as compared to those with low MVD, probably as a consequence of 5-FU-based therapy.We hypothesized a role for TP in oropharyngeal tumourigenesis and 5-FU activation in the adjuvant setting of OSC patients. JF - Journal of cellular and molecular medicine AU - Ranieri, G AU - Grammatica, L AU - Patruno, R AU - Zito, A F AU - Valerio, P AU - Iacobellis, S AU - Gadaleta, C AU - Gasparini, G AU - Ribatti, D AD - Department of Experimental Oncology, Unit of Interventional Radiology, Department of Critical Area and Surgery; National Cancer Institute of Bari, Bari, Italy. PY - 2007 SP - 362 EP - 368 VL - 11 IS - 2 SN - 1582-1838, 1582-1838 KW - Thymidine Phosphorylase KW - EC 2.4.2.4 KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Carcinoma, Squamous Cell -- pathology KW - Humans KW - Case-Control Studies KW - Carcinoma, Squamous Cell -- metabolism KW - Aged KW - Leukoplakia -- pathology KW - Immunohistochemistry KW - Carcinoma, Squamous Cell -- drug therapy KW - Male KW - Female KW - Age Distribution KW - Fluorouracil -- therapeutic use KW - Oropharyngeal Neoplasms -- drug therapy KW - Oropharyngeal Neoplasms -- pathology KW - Thymidine Phosphorylase -- metabolism KW - Oropharyngeal Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70469877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+and+molecular+medicine&rft.atitle=A+possible+role+of+thymidine+phosphorylase+expression+and+5-fluorouracil+increased+sensitivity+in+oropharyngeal+cancer+patients.&rft.au=Ranieri%2C+G%3BGrammatica%2C+L%3BPatruno%2C+R%3BZito%2C+A+F%3BValerio%2C+P%3BIacobellis%2C+S%3BGadaleta%2C+C%3BGasparini%2C+G%3BRibatti%2C+D&rft.aulast=Ranieri&rft.aufirst=G&rft.date=2007-03-01&rft.volume=11&rft.issue=2&rft.spage=362&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+and+molecular+medicine&rft.issn=15821838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-17 N1 - Date created - 2007-05-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Cell Mol Med. 2007 Nov-Dec;11(6):1419 [18053079] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Benefits of the combination of thalidomide plus cyclophosphamide in hormone refractory prostate cancer patients. AN - 70466019; 17471018 JF - Cancer biology & therapy AU - Al-Chalabi, Tania AU - Figg, William D AD - Molecular Pharmacology Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 318 EP - 319 VL - 6 IS - 3 SN - 1538-4047, 1538-4047 KW - Androgens KW - 0 KW - Thalidomide KW - 4Z8R6ORS6L KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - Humans KW - Clinical Trials, Phase I as Topic KW - Male KW - Androgens -- metabolism KW - Cyclophosphamide -- administration & dosage KW - Cyclophosphamide -- therapeutic use KW - Thalidomide -- adverse effects KW - Thalidomide -- administration & dosage KW - Thalidomide -- therapeutic use KW - Prostatic Neoplasms -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Cyclophosphamide -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70466019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+biology+%26+therapy&rft.atitle=Benefits+of+the+combination+of+thalidomide+plus+cyclophosphamide+in+hormone+refractory+prostate+cancer+patients.&rft.au=Al-Chalabi%2C+Tania%3BFigg%2C+William+D&rft.aulast=Al-Chalabi&rft.aufirst=Tania&rft.date=2007-03-01&rft.volume=6&rft.issue=3&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=Cancer+biology+%26+therapy&rft.issn=15384047&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-25 N1 - Date created - 2007-05-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Cancer Biol Ther. 2007 Mar;6(3):313-7 [17327701] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Research in child and adolescent psychopharmacology: recent accomplishments and new challenges. AN - 70458270; 16718480 AB - Research in pediatric psychopharmacology has expanded considerably in the last 10 years. Still, controversy remains about the effectiveness and safety of commonly used psychotropics and their role in child treatment, thus pointing to the need for more in-depth and targeted investigations. To review recent accomplishments and current limitations of pediatric psychopharmacology, and discuss approaches to further research. Selective review of the relevant literature and research in progress. Controlled clinical trials have been conducted in many common psychiatric disorders in children and adolescents, thus providing a basis on which evidence-based treatment guidelines can be constructed. Little innovation has, however, occurred in treatment development and testing. Safety concerns are prominent and have a major influence on clinical practice and drug utilization. While a research infrastructure has been successfully built for conducting pediatric clinical trials, important aspects such as long-term treatment effects, optimal sequencing and individualization of interventions, and integration of neuroscience findings into innovative, theory-driven treatment development remain to be addressed. JF - Psychopharmacology AU - Vitiello, Benedetto AD - Child and Adolescent Treatment and Preventive Intervention Research Branch, National Institute of Mental Health, Room 7147, 6001 Executive Blvd., MSC 9633, Bethesda, MD 20892-9633, USA. bvitiell@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 5 EP - 13 VL - 191 IS - 1 SN - 0033-3158, 0033-3158 KW - Psychotropic Drugs KW - 0 KW - Index Medicus KW - Humans KW - Treatment Outcome KW - Child KW - Patient Selection KW - Adolescent KW - Biomedical Research -- trends KW - Psychology, Child -- trends KW - Mental Disorders -- drug therapy KW - Psychotropic Drugs -- therapeutic use KW - Psychology, Adolescent -- trends KW - Mental Disorders -- psychology KW - Psychotropic Drugs -- adverse effects KW - Clinical Trials as Topic -- trends KW - Psychopharmacology -- trends KW - Clinical Trials as Topic -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70458270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Research+in+child+and+adolescent+psychopharmacology%3A+recent+accomplishments+and+new+challenges.&rft.au=Vitiello%2C+Benedetto&rft.aulast=Vitiello&rft.aufirst=Benedetto&rft.date=2007-03-01&rft.volume=191&rft.issue=1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-24 N1 - Date created - 2007-05-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Brain radiotherapy during treatment with anticonvulsant therapy as a trigger for toxic epidermal necrolysis. AN - 70438858; 17465258 AB - Toxic epidermal necrolysis (TEN) is a severe mucocutaneous syndrome that can be occasionally caused by anticonvulsant drugs. In some cases, cranial irradiation may act as a precipitating factor. Thus, in cancer patients who suffer from brain metastases and are administered antiepileptic drugs for seizure prophylaxis, the risk of developing TEN after receiving palliative brain radiotherapy cannot be ignored. We is reported. The case of a young patient with non-small cell lung cancer (NSCLC) treated with prophylactic phenobarbital who developed TEN within a few days of completing cranial radiotherapy for brain metastases is reported. To minimize the risk of TEN in patients undergoing brain radiotherapy, prophylactic anticonvulsant therapy is recommended only after an accurate measurement of the true benefits. Alternatively, discontinuation of antiepileptic treatment before the initiation of brain radiotherapy, or the use of anticonvulsants associated with a lower risk of developing cutaneous reactions might be considered. JF - Anticancer research AU - Metro, Giulio AU - Pino, Simona AU - Pellegrini, Domenica AU - Sacerdoti, Giorgio AU - Fabi, Alessandra AD - Department of Medical Oncology, Regina Elena National Cancer Institute, Rome, Italy. PY - 2007 SP - 1167 EP - 1169 VL - 27 IS - 2 SN - 0250-7005, 0250-7005 KW - Anticonvulsants KW - 0 KW - Index Medicus KW - Humans KW - Adult KW - Male KW - Lung Neoplasms -- pathology KW - Carcinoma, Non-Small-Cell Lung -- pathology KW - Brain Neoplasms -- radiotherapy KW - Anticonvulsants -- adverse effects KW - Stevens-Johnson Syndrome -- etiology KW - Brain Neoplasms -- secondary KW - Radiation Injuries -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70438858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anticancer+research&rft.atitle=Brain+radiotherapy+during+treatment+with+anticonvulsant+therapy+as+a+trigger+for+toxic+epidermal+necrolysis.&rft.au=Metro%2C+Giulio%3BPino%2C+Simona%3BPellegrini%2C+Domenica%3BSacerdoti%2C+Giorgio%3BFabi%2C+Alessandra&rft.aulast=Metro&rft.aufirst=Giulio&rft.date=2007-03-01&rft.volume=27&rft.issue=2&rft.spage=1167&rft.isbn=&rft.btitle=&rft.title=Anticancer+research&rft.issn=02507005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-10 N1 - Date created - 2007-04-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neurologic symptoms in licensed pesticide applicators in the Agricultural Health Study. AN - 70388012; 17439927 AB - Exposure to high levels of many pesticides has both acute and long-term neurologic consequences, but little is known about the neurotoxicity of chronic exposure to moderate pesticide levels. We analysed cross-sectional data from 18 782 Caucasian, male, licensed pesticide applicators, enrolled in the Agricultural Health Study from 1993 to 1997. Applicators provided information on lifetime pesticide use, and 23 neurologic symptoms typically associated with pesticide intoxication. Increased risk of experiencing >/=10 symptoms during the year before enrollment was associated with cumulative pesticide use, personally mixing or applying pesticides, pesticide-related medical care, diagnosed pesticide poisoning, and events involving high personal pesticide exposure. Greatest risk was associated with use of organophosphate and organochlorine insecticides. Results were similar after stratification by pesticide use during the year before enrollment, or exclusion of applicators with a history of pesticide poisoning, or high-exposure events. Use of pesticide application methods likely to involve high personal exposure was associated with greater risk. Groups of symptoms reflecting several neurologic domains, including affect, cognition, autonomic and motor function, and vision, were also associated with pesticide exposure. These results suggest that neurologic symptoms are associated with cumulative exposure to moderate levels of organophosphate and organochlorine insecticides, regardless of recent exposure or history of poisoning. JF - Human & experimental toxicology AU - Kamel, F AU - Engel, L S AU - Gladen, B C AU - Hoppin, J A AU - Alavanja, M C R AU - Sandler, D P AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, PO Box 12233, Research Triangle Park, NC 27709, USA. kamel@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 243 EP - 250 VL - 26 IS - 3 SN - 0960-3271, 0960-3271 KW - Hydrocarbons, Chlorinated KW - 0 KW - Organophosphorus Compounds KW - Pesticides KW - Index Medicus KW - Agriculture KW - Humans KW - Cohort Studies KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - North Carolina -- epidemiology KW - Adolescent KW - Male KW - Iowa -- epidemiology KW - Nervous System Diseases -- epidemiology KW - Hydrocarbons, Chlorinated -- toxicity KW - Organophosphorus Compounds -- toxicity KW - Occupational Exposure -- adverse effects KW - Nervous System Diseases -- chemically induced KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70388012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+%26+experimental+toxicology&rft.atitle=Neurologic+symptoms+in+licensed+pesticide+applicators+in+the+Agricultural+Health+Study.&rft.au=Kamel%2C+F%3BEngel%2C+L+S%3BGladen%2C+B+C%3BHoppin%2C+J+A%3BAlavanja%2C+M+C+R%3BSandler%2C+D+P&rft.aulast=Kamel&rft.aufirst=F&rft.date=2007-03-01&rft.volume=26&rft.issue=3&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Human+%26+experimental+toxicology&rft.issn=09603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-18 N1 - Date created - 2007-04-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cumulative lead dose and cognitive function in adults: a review of studies that measured both blood lead and bone lead. AN - 70373308; 17431502 AB - We review empirical evidence for the relations of recent and cumulative lead dose with cognitive function in adults. A systematic search of electronic databases resulted in 21 environmental and occupational studies from 1996 to 2006 that examined and compared associations of recent (in blood) and cumulative (in bone) lead doses with neurobehavioral outcomes. Data were abstracted after consideration of exclusion criteria and quality assessment, and then compiled into summary tables. At exposure levels encountered after environmental exposure, associations with bio-markers of cumulative dose (mainly lead in tibia) were stronger and more consistent than associations with blood lead levels. Similarly, in studies of former workers with past occupational lead exposure, associations were also stronger and more consistent with cumulative dose than with recent dose (in blood). In contrast, studies of currently exposed workers generally found associations that were more apparent with blood lead levels; we speculate that the acute effects of high, recent dose may mask the chronic effects of cumulative dose. There is moderate evidence for an association between psychiatric symptoms and lead dose but only at high levels of current occupational lead exposure or with cumulative dose in environmentally exposed adults. JF - Environmental health perspectives AU - Shih, Regina A AU - Hu, Howard AU - Weisskopf, Marc G AU - Schwartz, Brian S AD - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20892, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 483 EP - 492 VL - 115 IS - 3 SN - 0091-6765, 0091-6765 KW - Environmental Pollutants KW - 0 KW - Lead KW - 2P299V784P KW - Index Medicus KW - Humans KW - Adult KW - Bone and Bones -- metabolism KW - Environmental Pollutants -- toxicity KW - Cognition -- drug effects KW - Lead -- toxicity KW - Environmental Pollutants -- analysis KW - Lead -- analysis KW - Environmental Pollutants -- blood KW - Lead -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70373308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Cumulative+lead+dose+and+cognitive+function+in+adults%3A+a+review+of+studies+that+measured+both+blood+lead+and+bone+lead.&rft.au=Shih%2C+Regina+A%3BHu%2C+Howard%3BWeisskopf%2C+Marc+G%3BSchwartz%2C+Brian+S&rft.aulast=Shih&rft.aufirst=Regina&rft.date=2007-03-01&rft.volume=115&rft.issue=3&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-14 N1 - Date created - 2007-04-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Health Perspect. 2000 Mar;108(3):239-42 [10706530] Gerontology. 2000 Jul-Aug;46(4):219-27 [10859462] Neurotoxicology. 2000 Jun;21(3):365-78 [10894126] Neurology. 2000 Jul 12;55(1):134-6 [10891924] Neurology. 2000 Oct 24;55(8):1144-50 [11071492] Neurotoxicology. 2000 Oct;21(5):805-11 [11130286] Am J Epidemiol. 2001 Mar 1;153(5):453-64 [11226977] Neurotoxicology. 2000 Dec;21(6):1069-80 [11233753] Environ Health Perspect. 2001 Apr;109(4):361-8 [11335184] Toxicol Lett. 2001 Sep 15;123(2-3):195-207 [11641047] Arch Toxicol. 2001 Sep;75(7):439-42 [11693185] Behav Brain Res. 2001 Dec 14;127(1-2):199-207 [11718892] Occup Environ Med. 2002 Apr;59(4):217-23 [11934948] Arch Toxicol. 2002 Apr;76(3):137-45 [11967618] Environ Health Perspect. 2002 May;110(5):501-5 [12003753] Arch Neurol. 2002 May;59(5):787-93 [12020261] Psychol Aging. 2002 Jun;17(2):179-93 [12061405] Int Arch Occup Environ Health. 2002 Aug;75(6):394-8 [12070635] Occup Environ Med. 2002 Sep;59(9):648-9 [12205243] Epidemiology. 2003 Jan;14(1):30-6 [12500043] Occup Environ Med. 2003 Feb;60(2):145; 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AN - 70344667; 17407506 AB - Reduced right amygdala volumes have been reported in young, alcohol-naïve subjects at high risk (HR) for alcohol dependence. The differences in brain morphometry have been associated with an excess of externalizing behaviors in these subjects. This may reflect a neurobiological vulnerability to alcohol dependence. Existing Magnetic Resonance Imaging (MRI) studies on these subjects have examined only a few, pre-selected brain regions using the manual regions of interest (ROI) approach. MRI of HR subjects (n = 20) and age, sex, and handedness-matched low-risk (LR) subjects (n = 21) were analyzed using optimized voxel-based morphometry and ROI approach. The externalizing symptoms of these subjects and their fathers were measured using the Semi-Structured Assessment for the Genetics of Alcoholism. HR subjects had significantly smaller volumes of superior frontal, cingulate and parahippocampal gyri, amygdala, thalamus and cerebellum. These gray matter volumes correlated negatively with externalizing symptoms scores. Subjects at HR for alcoholism have reduced volumes of critical areas of brain gray matter, which are associated with increased externalizing symptoms. These represent key endophenotypes of alcoholism. JF - Addiction biology AU - Benegal, Vivek AU - Antony, George AU - Venkatasubramanian, Ganesan AU - Jayakumar, Peruvumba N AD - Department of Psychiatry, National Institute of Mental Health & Neurosciences, Bangalore, India. vbenegal@gmail.com Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 122 EP - 132 VL - 12 IS - 1 SN - 1355-6215, 1355-6215 KW - Index Medicus KW - Age Factors KW - Dominance, Cerebral -- physiology KW - Reference Values KW - Humans KW - Child KW - Amygdala -- pathology KW - Risk KW - Prefrontal Cortex -- pathology KW - Adult KW - Caudate Nucleus -- pathology KW - Statistics as Topic KW - Hippocampus -- pathology KW - Adolescent KW - Male KW - Magnetic Resonance Imaging KW - Attention Deficit Disorder with Hyperactivity -- psychology KW - Attention Deficit and Disruptive Behavior Disorders -- psychology KW - Attention Deficit Disorder with Hyperactivity -- genetics KW - Internal-External Control KW - Brain -- pathology KW - Conduct Disorder -- genetics KW - Conduct Disorder -- psychology KW - Alcoholism -- genetics KW - Image Processing, Computer-Assisted KW - Attention Deficit and Disruptive Behavior Disorders -- genetics KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70344667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+biology&rft.atitle=Gray+matter+volume+abnormalities+and+externalizing+symptoms+in+subjects+at+high+risk+for+alcohol+dependence.&rft.au=Benegal%2C+Vivek%3BAntony%2C+George%3BVenkatasubramanian%2C+Ganesan%3BJayakumar%2C+Peruvumba+N&rft.aulast=Benegal&rft.aufirst=Vivek&rft.date=2007-03-01&rft.volume=12&rft.issue=1&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Addiction+biology&rft.issn=13556215&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-30 N1 - Date created - 2007-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Region-specific down-regulation of Crhr1 gene expression in alcohol-preferring msP rats following ad lib access to alcohol. AN - 70344503; 17407495 AB - Corticotropin-releasing hormone 1 receptors (CRH-R1) mediate increased behavioral sensitivity to stress and excessive alcohol self-administration following a history of dependence. It was recently demonstrated that the genetically selected alcohol-preferring msP rat line replicates many characteristics of the post-dependent state, due to an innate up-regulation of the Crhr1 transcript in several limbic areas related to alcohol drinking motivation. Here, we examined whether voluntary alcohol consumption might be able to down-regulate Crhr1 transcript levels in msP rats in brain areas where elevated expression previously has been shown. Within central and medial amygdala (CeA, MeA), as well as the Nc. Accumbens, 2 weeks'ad lib access to alcohol led to a highly significant down-regulation of the Crhr1 transcript. Alcohol-induced Crhr1 down-regulation was not seen in cingulate cortex. These data support that recruitment of CRH-R1 signaling within components of the extended amygdala drives excessive alcohol intake, and that alcohol is voluntarily consumed in part for its ability to reduce CRH-R1 activity in this region. JF - Addiction biology AU - Hansson, Anita C AU - Cippitelli, Andrea AU - Sommer, Wolfgang H AU - Ciccocioppo, Roberto AU - Heilig, Markus AD - Laboratory of Clinical and Translational Studies, NIAAA/NIH, Bethesda, MD 20892-1108, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 30 EP - 34 VL - 12 IS - 1 SN - 1355-6215, 1355-6215 KW - CRF receptor type 1 KW - 0 KW - Receptors, Corticotropin-Releasing Hormone KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - In Situ Hybridization KW - Down-Regulation -- genetics KW - Gyrus Cinguli -- metabolism KW - Male KW - Amygdala -- metabolism KW - Nucleus Accumbens -- metabolism KW - Receptors, Corticotropin-Releasing Hormone -- genetics KW - Alcoholism -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70344503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+biology&rft.atitle=Region-specific+down-regulation+of+Crhr1+gene+expression+in+alcohol-preferring+msP+rats+following+ad+lib+access+to+alcohol.&rft.au=Hansson%2C+Anita+C%3BCippitelli%2C+Andrea%3BSommer%2C+Wolfgang+H%3BCiccocioppo%2C+Roberto%3BHeilig%2C+Markus&rft.aulast=Hansson&rft.aufirst=Anita&rft.date=2007-03-01&rft.volume=12&rft.issue=1&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Addiction+biology&rft.issn=13556215&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-30 N1 - Date created - 2007-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chemical genetic screening identifies critical pathways in anthrax lethal toxin-induced pathogenesis. AN - 70306742; 17379140 AB - Anthrax lethal toxin (LT)-induced cell death via mitogen-activated protein kinase kinase (MAPKK) cleavage remains questionable. Here, a chemical genetics approach was used to investigate what pathways mediate LT-induced cell death. Several small molecules were found to protect macrophages from anthrax LT cytotoxicity and MAPKK from cleavage by lethal factor (LF), without inhibiting LF enzymatic activity or cellular proteasome activity. Interestingly, the compounds activated MAPK-signaling molecules, induced proinflammatory cytokine production, and inhibited LT-induced macrophage apoptosis in a concentration-dependent manner. We propose that induction of antiapoptotic responses by MAPK-dependent or -independent pathways and activation of host innate responses may protect macrophages from anthrax LT-induced cell death. Altering host responses through a chemical genetics approach can help identify critical cellular pathways involved in the pathogenesis of anthrax and can be exploited to further explore host-pathogen interactions. JF - Chemistry & biology AU - Panchal, Rekha G AU - Ruthel, Gordon AU - Brittingham, Katherine C AU - Lane, Douglas AU - Kenny, Tara A AU - Gussio, Rick AU - Lazo, John S AU - Bavari, Sina AD - Target Structure-Based Drug Discovery Group, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA. rekha.panchal@amedd.army.mil Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 245 EP - 255 VL - 14 IS - 3 SN - 1074-5521, 1074-5521 KW - Antigens, Bacterial KW - 0 KW - Bacterial Toxins KW - Cell Cycle Proteins KW - Cytokines KW - anthrax toxin KW - Mitogen-Activated Protein Kinase Kinases KW - EC 2.7.12.2 KW - cdc25 Phosphatases KW - EC 3.1.3.48 KW - Index Medicus KW - Macrophages -- cytology KW - Microscopy, Confocal KW - Animals KW - Cell Cycle Proteins -- antagonists & inhibitors KW - Genetic Testing -- methods KW - Macrophages -- physiology KW - cdc25 Phosphatases -- antagonists & inhibitors KW - Cytokines -- metabolism KW - Mice KW - Cell Death -- drug effects KW - Macrophages -- drug effects KW - Necrosis KW - Apoptosis -- drug effects KW - Cell Line KW - Antigens, Bacterial -- toxicity KW - Mitogen-Activated Protein Kinase Kinases -- antagonists & inhibitors KW - Bacterial Toxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70306742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemistry+%26+biology&rft.atitle=Chemical+genetic+screening+identifies+critical+pathways+in+anthrax+lethal+toxin-induced+pathogenesis.&rft.au=Panchal%2C+Rekha+G%3BRuthel%2C+Gordon%3BBrittingham%2C+Katherine+C%3BLane%2C+Douglas%3BKenny%2C+Tara+A%3BGussio%2C+Rick%3BLazo%2C+John+S%3BBavari%2C+Sina&rft.aulast=Panchal&rft.aufirst=Rekha&rft.date=2007-03-01&rft.volume=14&rft.issue=3&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Chemistry+%26+biology&rft.issn=10745521&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-11 N1 - Date created - 2007-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). AN - 70293981; 17052995 AB - 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis is initiated by N(2)-hydroxylation, mediated by several cytochromes P450, including CYP1A1. However, the role of CYP1A1 in PhIP metabolic activation in vivo is unclear. In this study, Cyp1a1-null and wild-type (WT) mice were used to investigate the potential role of CYP1A1 in PhIP metabolic activation in vivo. PhIP N(2)-hydroxylation was actively catalyzed by lung homogenates of WT mice, at a rate of 14.9 +/- 5.0 pmol/min/g tissue, but <1 pmol/min/g tissue in stomach and small intestine, and almost undetectable in mammary gland and colon. PhIP N(2)-hydroxylation catalyzed by lung homogenates of Cyp1a1-null mice was approximately 10-fold lower than that of WT mice. In contrast, PhIP N(2)-hydroxylation activity in lung homogenates of Cyp1a2-null versus WT mice was not decreased. Pretreatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin increased lung Cyp1a1 mRNA and lung homogenate PhIP N(2)-hydroxylase activity approximately 50-fold in WT mice, where the activity was substantially inhibited (70%) by monoclonal antibodies against CYP1A1. In vivo, 30 min after oral treatment with PhIP, PhIP levels in lung were similar to those in liver. After a single dose of 0.1 mg/kg [(14)C]PhIP, lung PhIP-DNA adduct levels in Cyp1a1-null mice, but not in Cyp1a2-null mice, were significantly lower (P = 0.0028) than in WT mice. These results reveal that mouse lung has basal and inducible PhIP N(2)-hydroxylase activity predominantly catalyzed by CYP1A1. Because of the high inducibility of human CYP1A1, especially in cigarette smokers, the role of lung CYP1A1 in PhIP carcinogenesis should be considered. (237 words). JF - Carcinogenesis AU - Ma, Xiaochao AU - Idle, Jeffrey R AU - Malfatti, Michael A AU - Krausz, Kristopher W AU - Nebert, Daniel W AU - Chen, Chong-Sheng AU - Felton, James S AU - Waxman, David J AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 3106, Bethesda, MD 20892, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 732 EP - 737 VL - 28 IS - 3 SN - 0143-3334, 0143-3334 KW - Carcinogens KW - 0 KW - Imidazoles KW - 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine KW - 909C6UN66T KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Index Medicus KW - Animals KW - Enzyme Activation KW - Mice KW - Tissue Distribution KW - Female KW - Mice, Knockout KW - Imidazoles -- pharmacokinetics KW - Cytochrome P-450 CYP1A1 -- deficiency KW - Cytochrome P-450 CYP1A1 -- genetics KW - Carcinogens -- metabolism KW - Imidazoles -- metabolism KW - Cytochrome P-450 CYP1A1 -- metabolism KW - Lung -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70293981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Mouse+lung+CYP1A1+catalyzes+the+metabolic+activation+of+2-amino-1-methyl-6-phenylimidazo%5B4%2C5-b%5Dpyridine+%28PhIP%29.&rft.au=Ma%2C+Xiaochao%3BIdle%2C+Jeffrey+R%3BMalfatti%2C+Michael+A%3BKrausz%2C+Kristopher+W%3BNebert%2C+Daniel+W%3BChen%2C+Chong-Sheng%3BFelton%2C+James+S%3BWaxman%2C+David+J%3BGonzalez%2C+Frank+J&rft.aulast=Ma&rft.aufirst=Xiaochao&rft.date=2007-03-01&rft.volume=28&rft.issue=3&rft.spage=732&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-14 N1 - Date created - 2007-03-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Carcinogenesis. 1994 May;15(5):829-36 [8200083] Am J Med. 1992 Jul 15;93(1A):38S-42S [1497002] Food Chem Toxicol. 1995 Oct;33(10):821-8 [7590526] Carcinogenesis. 1995 Nov;16(11):2855-8 [7586209] Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1671-6 [8643688] Lung Cancer. 1996 Mar;14 Suppl 1:S93-8 [8785672] Carcinogenesis. 1997 Apr;18(4):851-4 [9111224] Carcinogenesis. 1997 Sep;18(9):1793-8 [9328177] Chest. 1997 Oct;112(4 Suppl):229S-234S [9337294] Int J Cancer. 1998 Jul 3;77(1):33-9 [9639391] Pharmacogenetics. 1998 Oct;8(5):375-82 [9825829] Carcinogenesis. 1998 Nov;19(11):1969-73 [9855011] Epidemiol Rev. 1998;20(2):218-36 [9919440] Carcinogenesis. 1999 Mar;20(3):353-68 [10190547] Epidemiology. 1999 Sep;10(5):488-94 [10468420] J Clin Oncol. 2005 May 10;23(14):3175-85 [15886304] Chem Res Toxicol. 2005 Sep;18(9):1471-8 [16167840] Biol Pharm Bull. 2006 Jan;29(1):67-70 [16394512] Biochem Biophys Res Commun. 2000 Jan 7;267(1):184-9 [10623596] Am J Epidemiol. 2000 Jan 15;151(2):140-7 [10645816] Toxicol Lett. 2001 Mar 31;120(1-3):199-208 [11323178] Lung Cancer. 2002 Feb;35(2):111-7 [11804682] Carcinogenesis. 2002 May;23(5):831-8 [12016157] Mutat Res. 2002 Sep 30;506-507:187-95 [12351158] Food Chem Toxicol. 2002 Oct;40(10):1529-33 [12387319] Crit Rev Toxicol. 2002 Sep;32(5):391-411 [12389869] Annu Rev Pharmacol Toxicol. 2003;43:149-73 [12171978] Carcinogenesis. 2003 Mar;24(3):583-7 [12663521] Mol Endocrinol. 2004 Aug;18(8):1975-87 [15155787] Mutat Res. 2004 Aug 8;562(1-2):151-62 [15279838] Toxicol Appl Pharmacol. 2004 Sep 15;199(3):210-9 [15364538] Methods Mol Biol. 2005;291:21-7 [15502208] Cancer Res. 1992 Sep 1;52(17):4682-7 [1511434] Carcinogenesis. 1993 Apr;14(4):585-92 [8472319] Carcinogenesis. 1993 Sep;14(9):1751-7 [8403195] Cancer Res. 1994 Jan 1;54(1):89-94 [8261468] Cancer Res. 1982 May;42(5):1798-808 [6175397] Int J Cancer. 1987 Nov 15;40(5):604-9 [2824385] Carcinogenesis. 1988 Aug;9(8):1411-6 [3402037] Carcinogenesis. 1989 Aug;10(8):1389-96 [2665964] J Natl Cancer Inst. 1990 Aug 15;82(16):1333-9 [2380990] J Biochem Toxicol. 1990 Winter;5(4):211-9 [2096217] Carcinogenesis. 1991 Oct;12(10):1945-7 [1934275] Carcinogenesis. 1994 Dec;15(12):2757-61 [8001231] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The importance of carcinogen dose in chemoprevention studies: quantitative interrelationships between, dibenzo[a,l]pyrene dose, chlorophyllin dose, target organ DNA adduct biomarkers and final tumor outcome. AN - 70290828; 16973675 AB - Chlorophyllin (CHL) is a potent antimutagen in vitro, an effective anti-carcinogen in several animal models, and significantly reduced urinary biomarkers of aflatoxin B(1) (AFB(1)) exposure in a human population. Here we report an expanded analysis of CHL chemoprevention using the potent environmental hydrocarbon dibenzo[a,l]pyrene (DBP). A dose-dose matrix design employed over 12 000 rainbow trout to evaluate the interrelationships among dietary carcinogen dose, anti-carcinogen dose, carcinogen-DNA adduct levels at exposure and eventual tumor outcome in two target organs. Included was an evaluation of the pharmaceutical CHL preparation (Derifil), used previously in a study of individuals chronically exposed to AFB(1). CHL was pre-, co- and post-fed at doses of 0-6000 p.p.m. and co-fed with DBP at doses of 0-371.5 p.p.m. for 4 weeks. This protocol generated a total of 21 dose-dose treatment groups, each evaluated with three or more replicates of 100 animals. The DBP-only treatment produced dose-responsive increases in liver and stomach DBP-DNA adducts, whereas increasing CHL co-treatment doses produced successive inhibition in liver (49-83%) and stomach (47-75%) adduct levels at each DBP dose examined. The remaining 8711 trout were necropsied, 10 months later. DBP treatment alone produced a logit incidence versus log [DBP] dose-response curve in stomach that was linear; CHL co-treatment provided dose-dependent tumor inhibition which ranged from 30 to 68% and was predictable from the adduct response. The Derifil CHL preparation was also found to effectively reduce DNA adduction and final tumor incidence in stomach (as well as liver), with a potency compatible with its total chlorin content. Liver tumor incidence in the DBP-only groups appeared to plateau near 60%. At DBP doses of A polymorphism [TA genotype: odds ratio (OR)=1.32, 95% confidence interval (CI)=0.86-2.02; AA, OR=1.84, 95% CI=1.10-3.08; trend test, P=0.02]. Our most noteworthy TNF finding was an association between -857C>T and a decreased risk of NHL (CT or TT, OR=0.59, 95% CI=0.42-0.84, P=0.003) and particularly follicular lymphoma (OR=0.40, 95% CI=0.23-0.68, P=0.0009). Additionally, TNF -863C>A was associated with an elevated risk of DLBCL (CA, OR=1.45, 95% CI=0.95-2.21; AA, OR=2.06, 95% CI=0.88-4.83; trend test, P=0.02). Our findings offer further evidence that variation in the IL10 and TNF loci influences NHL risk. Additional studies are needed to clarify the genetic and biologic basis for these relationships. JF - Carcinogenesis AU - Purdue, Mark P AU - Lan, Qing AU - Kricker, Anne AU - Grulich, Andrew E AU - Vajdic, Claire M AU - Turner, Jennifer AU - Whitby, Denise AU - Chanock, Stephen AU - Rothman, Nathaniel AU - Armstrong, Bruce K AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892-7240, USA. purduem@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 704 EP - 712 VL - 28 IS - 3 SN - 0143-3334, 0143-3334 KW - Interleukins KW - 0 KW - Lymphotoxin-alpha KW - Receptors, Cell Surface KW - Receptors, Leptin KW - Tumor Necrosis Factor-alpha KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Lymphotoxin-alpha -- genetics KW - Humans KW - Lymphoma, B-Cell -- epidemiology KW - Aged KW - Lymphoma, B-Cell -- genetics KW - Chromosome Mapping KW - Registries KW - Lymphoma, B-Cell -- immunology KW - Risk Factors KW - Adult KW - Middle Aged KW - Receptors, Cell Surface -- genetics KW - New South Wales -- epidemiology KW - Amino Acid Substitution KW - Female KW - Male KW - Lymphoma, Non-Hodgkin -- genetics KW - Lymphoma, Non-Hodgkin -- epidemiology KW - Polymorphism, Genetic KW - Lymphoma, Non-Hodgkin -- immunology KW - Tumor Necrosis Factor-alpha -- genetics KW - Interleukins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70285731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Polymorphisms+in+immune+function+genes+and+risk+of+non-Hodgkin+lymphoma%3A+findings+from+the+New+South+Wales+non-Hodgkin+Lymphoma+Study.&rft.au=Purdue%2C+Mark+P%3BLan%2C+Qing%3BKricker%2C+Anne%3BGrulich%2C+Andrew+E%3BVajdic%2C+Claire+M%3BTurner%2C+Jennifer%3BWhitby%2C+Denise%3BChanock%2C+Stephen%3BRothman%2C+Nathaniel%3BArmstrong%2C+Bruce+K&rft.aulast=Purdue&rft.aufirst=Mark&rft.date=2007-03-01&rft.volume=28&rft.issue=3&rft.spage=704&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-14 N1 - Date created - 2007-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Environmental and behavioral factors and the risk of non-Hodgkin lymphoma. AN - 70282759; 17344463 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Hartge, Patricia AU - Smith, Martyn T AD - National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20892, USA. hartge@nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 367 EP - 368 VL - 16 IS - 3 SN - 1055-9965, 1055-9965 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - Occupational Exposure KW - Epidemiologic Studies KW - Sunlight -- adverse effects KW - Risk Factors KW - Humans KW - Genetic Predisposition to Disease KW - Occupations KW - Life Style KW - Environment KW - Lymphoma, Non-Hodgkin -- epidemiology KW - Lymphoma, Non-Hodgkin -- etiology KW - Lymphoma, Non-Hodgkin -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70282759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Environmental+and+behavioral+factors+and+the+risk+of+non-Hodgkin+lymphoma.&rft.au=Hartge%2C+Patricia%3BSmith%2C+Martyn+T&rft.aulast=Hartge&rft.aufirst=Patricia&rft.date=2007-03-01&rft.volume=16&rft.issue=3&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-03 N1 - Date created - 2007-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity. AN - 70277413; 17096185 AB - Curcumin (diferuloylmethane), a natural cancer chemopreventive compound, has been tested for its action in acute myeloblastic leukemia cell line HL-60. The results clearly show that curcumin induces apoptosis in these cells as evidenced by the release of cytochrome c from mitochondria to the cytosol and increase in the DNA content in sub G1 region as observed in FACS analysis. Apoptosis is apparently mediated by up-regulation of apoptotic gene bax and simultaneous down-regulation of anti-apoptotic gene bcl-2 followed by activation of caspases 3 and 8 and degradation of PARP. Telomerase, a reverse transcriptase, has been found to be activated in more than 80% of human cancers and, therefore, can be considered as a potential marker for tumorigenesis. Certain natural compounds have the potential of inhibiting telomerase activity leading to suppression of cell viability and induction of apoptosis. The present study shows that curcumin-induced apoptosis coincides with the inhibition of telomerase activity in a dose dependent manner. JF - Molecular and cellular biochemistry AU - Mukherjee Nee Chakraborty, Sutapa AU - Ghosh, Utpal AU - Bhattacharyya, N P AU - Bhattacharya, R K AU - Dey, Subhabrata AU - Roy, Madhumita AD - Department of Environmental Carcinogenesis & Toxicology, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700 026, India. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 31 EP - 39 VL - 297 IS - 1-2 SN - 0300-8177, 0300-8177 KW - Antineoplastic Agents KW - 0 KW - Apoptosis Regulatory Proteins KW - DNA, Neoplasm KW - Proto-Oncogene Proteins c-bcl-2 KW - bcl-2-Associated X Protein KW - Cytochromes c KW - 9007-43-6 KW - Poly(ADP-ribose) Polymerases KW - EC 2.4.2.30 KW - Telomerase KW - EC 2.7.7.49 KW - Caspase 3 KW - EC 3.4.22.- KW - Caspase 8 KW - Curcumin KW - IT942ZTH98 KW - Index Medicus KW - Caspase 8 -- metabolism KW - Protein Processing, Post-Translational -- drug effects KW - Dose-Response Relationship, Drug KW - HL-60 Cells KW - Humans KW - Cytochromes c -- secretion KW - DNA, Neoplasm -- analysis KW - Poly(ADP-ribose) Polymerases -- metabolism KW - bcl-2-Associated X Protein -- metabolism KW - Apoptosis Regulatory Proteins -- metabolism KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Flow Cytometry KW - Caspase 3 -- metabolism KW - Leukemia -- pathology KW - Telomerase -- antagonists & inhibitors KW - Apoptosis -- drug effects KW - Antineoplastic Agents -- pharmacology KW - Leukemia -- enzymology KW - Curcumin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70277413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biochemistry&rft.atitle=Curcumin-induced+apoptosis+in+human+leukemia+cell+HL-60+is+associated+with+inhibition+of+telomerase+activity.&rft.au=Mukherjee+Nee+Chakraborty%2C+Sutapa%3BGhosh%2C+Utpal%3BBhattacharyya%2C+N+P%3BBhattacharya%2C+R+K%3BDey%2C+Subhabrata%3BRoy%2C+Madhumita&rft.aulast=Mukherjee+Nee+Chakraborty&rft.aufirst=Sutapa&rft.date=2007-03-01&rft.volume=297&rft.issue=1-2&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biochemistry&rft.issn=03008177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-18 N1 - Date created - 2007-03-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The FMR1 premutation and reproduction. AN - 70272082; 17074338 AB - To update clinicians on the reproductive implications of premutations in FMR1 (fragile X mental retardation 1). Fragile X syndrome, a cause of mental retardation and autism, is due to a full mutation (>200 CGG repeats). Initially, individuals who carried the premutation (defined as more than 55 but less than 200 CGG repeats) were not considered at risk for any clinical disorders. It is now recognized that this was incorrect, specifically with respect to female reproduction. Literature review and consensus building at two multidisciplinary scientific workshops. Convincing evidence now relates the FMR1 premutation to altered ovarian function and loss of fertility. An FMR1 mRNA gain-of-function toxicity may underlie this altered ovarian function. There are major gaps in knowledge regarding the natural history of the altered ovarian function in women who carry the FMR1 premutation, making counseling about reproductive plans a challenge. Women with premature ovarian failure are at increased risk of having an FMR1 premutation and should be informed of the availability of fragile X testing. Specialists in reproductive medicine can provide a supportive environment in which to explain the implications of FMR1 premutation testing, facilitate access to testing, and make appropriate referral to genetic counselors. JF - Fertility and sterility AU - Wittenberger, Michael D AU - Hagerman, Randi J AU - Sherman, Stephanie L AU - McConkie-Rosell, Allyn AU - Welt, Corrine K AU - Rebar, Robert W AU - Corrigan, Emily C AU - Simpson, Joe Leigh AU - Nelson, Lawrence M AD - Intramural Research Program, Section on Women's Health Research, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1103, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 456 EP - 465 VL - 87 IS - 3 KW - FMR1 protein, human KW - 0 KW - Fragile X Mental Retardation Protein KW - 139135-51-6 KW - Index Medicus KW - Genetic Testing KW - Humans KW - Adult KW - Adolescent KW - Trinucleotide Repeat Expansion KW - Genetic Counseling KW - Preimplantation Diagnosis KW - Male KW - Female KW - Pregnancy KW - Fragile X Syndrome -- therapy KW - Fragile X Syndrome -- genetics KW - Primary Ovarian Insufficiency -- etiology KW - Fragile X Syndrome -- physiopathology KW - Fragile X Mental Retardation Protein -- genetics KW - Primary Ovarian Insufficiency -- genetics KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70272082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Maternal+seafood+consumption+in+pregnancy+and+neurodevelopmental+outcomes+in+childhood+%28ALSPAC+study%29%3A+an+observational+cohort+study&rft.au=Hibbeln%2C+J+R%3BDavis%2C+J+M%3BSteer%2C+C%3BEmmett%2C+P%3BRogers%2C+I%3BWilliams%2C+C%3BGolding%2C+J&rft.aulast=Hibbeln&rft.aufirst=J&rft.date=2007-02-23&rft.volume=369&rft.issue=9561&rft.spage=578&rft.isbn=&rft.btitle=&rft.title=Lancet&rft.issn=00995355&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-30 N1 - Date created - 2007-03-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Fertil Steril. 2007 Nov;88(5):1477; author reply 1477 [17991519] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interhemispheric inhibition in distal and proximal arm representations in the primary motor cortex. AN - 70268045; 17215494 AB - Interhemispheric inhibitory interactions (IHI) operate between homologous distal hand representations in primary motor cortex (M1). It is not known whether proximal arm representations exhibit comparable effects on their homologous counterparts. We studied IHI in different arm representations, targeting triceps brachii (TB, n = 13), first dorsal interosseous (FDI, n = 13), and biceps brachii (BB, n = 7) muscles in healthy volunteers. Transcranial magnetic stimulation test stimuli (TS) were delivered to M1 contralateral to the target muscle preceded 10 ms by a conditioning stimulus (CS) to the opposite M1 at 110-150% resting motor threshold (RMT). IHI was calculated as the ratio between motor-evoked potential (MEP) amplitudes in conditioned relative to unconditioned trials. Mean RMTs were 38.9, 46.9, and 46.0% of stimulator output in FDI, TB, and BB muscles, respectively. IHI was 0.45 +/- 0.41 (FDI), 0.78 +/- 0.38 (TB), and 0.52 +/- 0.32 (BB, P < 0.01) when test MEP amplitudes were matched and 0.28 +/- 0.17 (FDI) and 0.85 +/- 0.31 (TB, P < 0.05) when TS intensities expressed as percentage RMT were matched. Significant IHI (P < 0.05) was identified with minimal CS intensities (expressed as percentage stimulator output) in the 30 s for FDI, 60 s for TB, and 40 s for BB. Additionally, a CS of roughly 120% RMT suppressed the test MEP but not a test H-reflex in BB, suggesting IHI observed in BB is likely mediated by a supraspinal mechanism. We conclude that IHI differs between different arm muscle representations, comparable between BB and FDI but lesser for TB. This finding suggests the amount of IHI between different arm representations does not strictly follow a proximal-to-distal gradient, but may be related to the role of each muscle in functional movement synergies. JF - Journal of neurophysiology AU - Harris-Love, Michelle L AU - Perez, Monica A AU - Chen, Robert AU - Cohen, Leonardo G AD - Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, 10 Center Drive, MSC 1428, Bldg. 10, Rm 5N226, Bethesda, MD 20892, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 2511 EP - 2515 VL - 97 IS - 3 SN - 0022-3077, 0022-3077 KW - Index Medicus KW - Electric Stimulation -- methods KW - Analysis of Variance KW - Muscle, Skeletal -- radiation effects KW - Transcranial Magnetic Stimulation -- methods KW - H-Reflex -- radiation effects KW - Muscle, Skeletal -- physiology KW - Humans KW - Adult KW - H-Reflex -- physiology KW - Dose-Response Relationship, Radiation KW - Male KW - Arm -- physiology KW - Neural Inhibition -- radiation effects KW - Arm -- innervation KW - Motor Cortex -- physiology KW - Evoked Potentials, Motor -- physiology KW - Neural Inhibition -- physiology KW - Functional Laterality -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70268045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurophysiology&rft.atitle=Interhemispheric+inhibition+in+distal+and+proximal+arm+representations+in+the+primary+motor+cortex.&rft.au=Harris-Love%2C+Michelle+L%3BPerez%2C+Monica+A%3BChen%2C+Robert%3BCohen%2C+Leonardo+G&rft.aulast=Harris-Love&rft.aufirst=Michelle&rft.date=2007-03-01&rft.volume=97&rft.issue=3&rft.spage=2511&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurophysiology&rft.issn=00223077&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-21 N1 - Date created - 2007-03-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The diagnostic value of C-reactive protein, interleukin-8, and monocyte chemotactic protein in risk stratification of febrile neutropenic children with hematologic malignancies. AN - 70259289; 17356388 AB - Recent advances in febrile neutropenia have highlighted the value of risk stratification especially that it can have important implications in terms of management. We aimed to identify a serum marker that may help to stratify febrile neutropenic pediatric patients treated for hematologic malignancies at the time of first evaluation. Thus, C-reactive protein (CRP), interleukin-8 (IL-8), and monocyte chemotactic protein-1-alpha (MCP-1-alpha) were evaluated for their predictive and diagnostic relevance in febrile episodes of cancer patients. Within 24 hours of fever, CRP, IL-8, and MCP-1 serum levels were measured and the levels of these markers were related to the clinical findings of the patients. For this purpose, we collected and analyzed clinical data of 85 fever episodes occurring in 76 patients with hematologic malignancies, presenting to the Department of Pediatric Oncology, National Cancer Institute, Cairo University, during a 6-month period. Neutropenic children with febrile episodes were classified into 2 groups, a group with unexplainable fever (group I, n=26) and another group with either blood culture positive, and/or fever periods with a documented clinical sepsis and/or local infection (group II, n=59). Clinically, local sites of infection were encountered in 39 cases (45.9%), whereas a positive blood culture was detected in 20 cases. CRP, IL-8, and MCP-1 levels were significantly lower in group I versus group II (P value or =90 mg/L was significantly associated with chemotherapy-related neutropenia and fever owing to bacteremia (P=0.038). The sensitivity, specificity, negative and positive predictive values of CRP, MCP-1, and IL-8 were (70%, 73%, 51%, and 85%), (64%, 92%, 53%, and 95%), and (71%, 77%, 54%, and 88%), respectively. Combining 2 or 3 markers improved the diagnostic performance of these test, as 78% of group II had elevated 2 or 3 markers versus 16% of the group with no evident infection. Low levels of CRP, MCP-1, and IL-8 could identify patients with unexplainable fever; whereas, high levels of these markers were of help in the diagnosis of infectious episodes. A model combining more than 1 marker is recommended in the assessment of febrile neutropenia. JF - Journal of pediatric hematology/oncology AU - El-Maghraby, Shereen Mohamed AU - Moneer, Manar Mohamed AU - Ismail, Manar Mohamed AU - Shalaby, Lobna M AU - El-Mahallawy, Hadir Ahmed AD - Clinical Pathology Department, Epidemiology and Biostastics Department, Pediatric Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt. shereenmaghraby36@yahoo.com Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 131 EP - 136 VL - 29 IS - 3 SN - 1077-4114, 1077-4114 KW - Anti-Bacterial Agents KW - 0 KW - Chemokine CCL2 KW - Interleukin-8 KW - C-Reactive Protein KW - 9007-41-4 KW - Index Medicus KW - Anti-Bacterial Agents -- therapeutic use KW - Reference Values KW - Bacteremia -- drug therapy KW - Humans KW - Fever -- microbiology KW - Prognosis KW - Fever -- diagnosis KW - Predictive Value of Tests KW - Child KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Fever -- drug therapy KW - Child, Preschool KW - Infant KW - Prospective Studies KW - Bacteremia -- microbiology KW - Bacteremia -- blood KW - Risk Factors KW - Treatment Outcome KW - Adolescent KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Male KW - Female KW - Chemokine CCL2 -- blood KW - Leukemia -- drug therapy KW - Leukemia -- diagnosis KW - Hematologic Neoplasms -- diagnosis KW - Hematologic Neoplasms -- microbiology KW - Hematologic Neoplasms -- drug therapy KW - Neutropenia -- drug therapy KW - Neutropenia -- diagnosis KW - Interleukin-8 -- blood KW - C-Reactive Protein -- analysis KW - Leukemia -- microbiology KW - Neutropenia -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70259289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pediatric+hematology%2Foncology&rft.atitle=The+diagnostic+value+of+C-reactive+protein%2C+interleukin-8%2C+and+monocyte+chemotactic+protein+in+risk+stratification+of+febrile+neutropenic+children+with+hematologic+malignancies.&rft.au=El-Maghraby%2C+Shereen+Mohamed%3BMoneer%2C+Manar+Mohamed%3BIsmail%2C+Manar+Mohamed%3BShalaby%2C+Lobna+M%3BEl-Mahallawy%2C+Hadir+Ahmed&rft.aulast=El-Maghraby&rft.aufirst=Shereen&rft.date=2007-03-01&rft.volume=29&rft.issue=3&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Journal+of+pediatric+hematology%2Foncology&rft.issn=10774114&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-13 N1 - Date created - 2007-03-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neuroprotective peptides prevent some alcohol-induced alteration in gamma-aminobutyric acid A-beta3, which plays a role in cleft lip and palate and learning in fetal alcohol syndrome. AN - 70246690; 17346546 AB - Prenatal alcohol exposure affects 1 in 100 births in the United States and results in craniofacial dysmorphologic condition and learning disabilities. In a model for fetal alcohol syndrome, neuroprotective peptides prevented fetal death and learning deficits. The gamma-aminobutyric acid A (GABA) receptor subunit GABAbeta3 plays a critical role for nervous system and palate development. Our objective was to determine whether the neuropeptides prevented alcohol-induced damage through GABAbeta3. With a model for fetal alcohol syndrome, timed pregnant C57B16/J mice were treated on gestational day 8 with alcohol (25% alcohol) or control (saline solution) or alcohol plus peptides NAPVSIPQ + SALLRSIPA (NAP + SAL; 20 microg). Embryos were harvested at 6 and 24 hours and 10 days after treatment. Adult males were tested for learning on the Morris water maze, and their brains were dissected. With samples from at least 3 litters per time point, calibrator-normalized relative real-time polymerase chain reaction was performed for GABAbeta3 with glyceraldehyde-3-phosphate dehydrogenase standardization. Statistical analysis included analysis of variance and Fisher protected least significant difference. Twenty-four hours and 10 days after treatment, alcohol decreased GABAbeta3 in the embryos (P < or = .01); this decrease was prevented by the peptides (P = .01). GABAbeta3 was higher in alcohol treated adult brains respect to the controls (P = .002); this rise was not prevented by the peptides. Treatment with the neuropeptides NAPVSIPQ and SALLRSIPA prevented the alcohol-induced decline in GABAbeta3 expression 10 days after alcohol exposure. Because palate formation continues through E18, NAPVSIPQ and SALLRSIPA may be beneficial for the prevention of cleft lip and palate. JF - American journal of obstetrics and gynecology AU - Toso, Laura AU - Roberson, Robin AU - Abebe, Daniel AU - Spong, Catherine Y AD - Unit on Perinatal and Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. tosol@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 259.e1 EP - 5 VL - 196 IS - 3 KW - GABRB3 protein, human KW - 0 KW - Gabrb3 protein, mouse KW - Oligopeptides KW - Receptors, GABA-A KW - seryl-alanyl-leucy-leucyl-arginyl-seryl-isoleucyl-prolyl-alanine KW - Ethanol KW - 3K9958V90M KW - davunetide KW - GF00K3IIWE KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Mice, Inbred C57BL KW - Mice KW - Female KW - Pregnancy KW - Ethanol -- adverse effects KW - Cleft Palate -- chemically induced KW - Receptors, GABA-A -- physiology KW - Ethanol -- antagonists & inhibitors KW - Receptors, GABA-A -- drug effects KW - Oligopeptides -- pharmacology KW - Learning Disorders -- chemically induced KW - Fetal Alcohol Spectrum Disorders -- etiology KW - Cleft Lip -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70246690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Imaging+Immune+Responses+%28J7%29&rft.atitle=Directed+Cell-Cell+Interactions+in+the+Development+of+Adaptive+Immunity&rft.au=Germain%2C+Ronald+N&rft.aulast=Germain&rft.aufirst=Ronald&rft.date=2007-02-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Imaging+Immune+Responses+%28J7%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-03 N1 - Date created - 2007-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Early clinical and radiological pulmonary complications following breast cancer radiation therapy: NTCP fit with four different models. AN - 70243636; 17224197 AB - To fit four different NTCP (Normal Tissue Complication Probability) models to prospectively collected data on short-term pulmonary complications following breast cancer radiotherapy (RT). Four hundred and seventy-five breast cancer patients, referred to the Radiotherapy Department at Stockholm Söder Hospital (1994-1998) for adjuvant post-operative RT were prospectively followed for pulmonary complications 1, 4 and 7 months after the completion of RT. Eighty-seven patients with complete dose-volume histogram (DVH) of the ipsilateral lung were selected for the present analysis. Mean dose to the ipsilateral lateral lung ranged from 2.5 to 18Gy (median 12Gy). Three different endpoints were considered: (1) clinical pneumonitis scored according to CTC-NCIC criteria: asymptomatic (grade 0) vs grade 1 and grade 2; (2) radiological changes assessed with diagnostic chest X-ray: no/slight radiological changes vs moderate/severe; (3) radiological changes assessed with CT: no/slight vs moderate/severe. Four NTCP models were used: the Lyman model with DVH reduced to the equivalent uniform dose (LEUD), the Logit model with DVH reduced to EUD, the Mean Lung Dose (MLD) model and the Relative Seriality (RS) model. The data fitting procedure was done using the maximum likelihood analysis. The analysis was done on the entire population (n=87) and on a subgroup of patients treated with loco-regional RT (n=44). 24/87 patients (28%) developed clinical pneumonitis; 28/81 patients (35%) had radiological side effects on chest X-rays and 11/75 patients (15%) showed radiological density changes on Computed Tomography (CT). The analysis showed that the risk of clinical pneumonitis was a smooth function of EUD (calculated from DVH using n=0.86+/-0.10, best fit result). With LEUD, the relationship between EUD and NTCP could be described with a D(50) of 16.4Gy+/-1.1Gy and a steepness parameter m of 0.36+/-0.7. The results found in the overall population were substantially confirmed in the subgroup of patients treated with loco-regional RT. A large group of prospective patient data (87 pts), including grade 1 pneumonitis, were analysed. The four NTCP models fit quite accurately the considered endpoints. EUD or the mean lung dose are robust and simple parameters correlated with the risk of pneumonitis. For all endpoints the D(50) values ranged in an interval between 10 and 20Gy. JF - Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology AU - Rancati, Tiziana AU - Wennberg, Berit AU - Lind, Pehr AU - Svane, Gunilla AU - Gagliardi, Giovanna AD - National Cancer Institute, Milan, Italy. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 308 EP - 316 VL - 82 IS - 3 SN - 0167-8140, 0167-8140 KW - Index Medicus KW - Radiotherapy Planning, Computer-Assisted KW - Probability KW - Prospective Studies KW - Combined Modality Therapy KW - Radiotherapy Dosage KW - Humans KW - Tomography, X-Ray Computed KW - Middle Aged KW - Pneumonia -- etiology KW - Female KW - Lung Diseases -- etiology KW - Radiotherapy -- methods KW - Breast Neoplasms -- surgery KW - Breast Neoplasms -- radiotherapy KW - Radiation Injuries KW - Radiotherapy -- adverse effects KW - Models, Theoretical KW - Lung -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70243636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiotherapy+and+oncology+%3A+journal+of+the+European+Society+for+Therapeutic+Radiology+and+Oncology&rft.atitle=Early+clinical+and+radiological+pulmonary+complications+following+breast+cancer+radiation+therapy%3A+NTCP+fit+with+four+different+models.&rft.au=Rancati%2C+Tiziana%3BWennberg%2C+Berit%3BLind%2C+Pehr%3BSvane%2C+Gunilla%3BGagliardi%2C+Giovanna&rft.aulast=Rancati&rft.aufirst=Tiziana&rft.date=2007-03-01&rft.volume=82&rft.issue=3&rft.spage=308&rft.isbn=&rft.btitle=&rft.title=Radiotherapy+and+oncology+%3A+journal+of+the+European+Society+for+Therapeutic+Radiology+and+Oncology&rft.issn=01678140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-07 N1 - Date created - 2007-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques. AN - 70238520; 17339526 AB - Innate differences in opioid neurotransmission are hypothesized to influence abuse liability of alcohol. In humans, a variant of the mu-opioid receptor gene (OPRM1A118G) increases receptor affinity, alcohol-induced euphoria, and risk for alcohol use disorders. To determine whether a variant in the mu-opioid receptor gene (OPRM1C77G) that increases affinity of the receptor is associated with alcohol response and consumption in macaques. Young adult rhesus macaques (Macaca mulatta) were intravenously administered 2.0 to 2.1 g of ethanol per kilogram of body weight and assessed for alcohol response. Animals were later given simultaneous access to an aspartame-sweetened 8.4% (vol/vol) ethanol solution and a vehicle for 1 hour per day, 5 days a week, for a period of 6 weeks. Animals (N = 82) were genotyped for the OPRM1C77G polymorphism; the effects of the genotype on alcohol response and consumption were determined by analysis of variance, with sex included as a nominal independent variable. Alcohol response (ataxia, stimulation, and sedation), average alcohol consumption, the percentage of days during which an animal consumed alcohol at a level sufficient to produce intoxication (> or =0.67 g of alcohol per kilogram of body weight), and alcohol preference (calculated as 100 x {alcoholic solution/[alcoholic solution + nonalcoholic solution]}). Increased alcohol-induced stimulation was observed among male macaques carrying the OPRM1C77G allele. OPRM1C77G allele carriers consumed more ethanol and exhibited increased ethanol preference. Male carriers of the OPRM1C77G allele exhibited higher alcohol preference and consumption, and drank to intoxication more frequently than did C/C males. These findings demonstrate that the rhesus macaques' equivalent of the OPRM1A118G variant is associated with increased alcohol response, consumption, and preference. Our results reveal effects of the OPRM1C77G genotype to be male-restricted or more marked among male macaques. This is of interest, given the fact that early-onset type II alcoholism is more common among men and that, among addicted individuals, men are more responsive to mu-opioid receptor blockade. JF - Archives of general psychiatry AU - Barr, Christina S AU - Schwandt, Melanie AU - Lindell, Stephen G AU - Chen, Scott A AU - Goldman, David AU - Suomi, Stephen J AU - Higley, J Dee AU - Heilig, Markus AD - Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Poolesville, MD 20837, USA. cbarr@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 369 EP - 376 VL - 64 IS - 3 SN - 0003-990X, 0003-990X KW - Receptors, Opioid, mu KW - 0 KW - Ethanol KW - 3K9958V90M KW - Abridged Index Medicus KW - Index Medicus KW - Genotype KW - Conditioning, Operant -- drug effects KW - Drinking Behavior -- drug effects KW - Animals KW - Sex Factors KW - Alcoholism -- epidemiology KW - Age of Onset KW - Conditioning, Operant -- physiology KW - Drinking Behavior -- physiology KW - Disease Models, Animal KW - Genetic Variation -- genetics KW - Male KW - Behavior, Animal -- drug effects KW - Ethanol -- pharmacology KW - Polymorphism, Genetic -- genetics KW - Macaca mulatta -- genetics KW - Behavior, Animal -- physiology KW - Alcohol Drinking -- genetics KW - Receptors, Opioid, mu -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70238520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=Association+of+a+functional+polymorphism+in+the+mu-opioid+receptor+gene+with+alcohol+response+and+consumption+in+male+rhesus+macaques.&rft.au=Barr%2C+Christina+S%3BSchwandt%2C+Melanie%3BLindell%2C+Stephen+G%3BChen%2C+Scott+A%3BGoldman%2C+David%3BSuomi%2C+Stephen+J%3BHigley%2C+J+Dee%3BHeilig%2C+Markus&rft.aulast=Barr&rft.aufirst=Christina&rft.date=2007-03-01&rft.volume=64&rft.issue=3&rft.spage=369&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-08 N1 - Date created - 2007-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mesothelin expression in human lung cancer. AN - 70226107; 17332303 AB - To investigate mesothelin as a new target for immunotherapy in lung cancer. Mesothelin mRNA and protein expression were assessed by reverse transcription-PCR, immunoblotting, and immunohistochemistry in human lung cancer specimens. Expression was also characterized in human lung cancer cell lines by flow cytometry and immunoblotting. The SS1P immunotoxin specific for mesothelin was assessed for its cytotoxic activity against lung cancer cells. We found that mesothelin mRNA was expressed in 83% of lung adenocarcinomas (10 of 12 patients). The mesothelin precursor protein was detected in 82% of lung adenocarcinoma (9 of 11 patients), and its mature form was detected in 55% (6 of 11 patients). Immunohistochemistry showed strong and diffuse mesothelin staining in human lung adenocarcinomas and weak or modest staining in squamous cell carcinomas. We detected mesothelin mRNA in 78% of lung cancer cell lines (7 of 9) of the NCI-60 cell line panel. Mesothelin mRNA and proteins were expressed at a high level in non-small cell lung cancer lines EKVX, NCI-H460, NCI-H322M, and NCI-H522. Flow cytometric analysis showed high surface expression of mesothelin in NCI-H322M and EKVX cell lines. Immunotoxin SS1P showed high cytotoxic activity on NCI-H322M and EKVX cells with IC(50) values ranging from 2 to 5 ng/mL. Mesothelin is expressed on the surface of most lung adenocarcinoma cells. Immunotoxin SS1P is cytotoxic against mesothelin-expressing lung cancer cell lines and merits evaluation as a new therapeutic agent in treating non-small cell lung cancer. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Ho, Mitchell AU - Bera, Tapan K AU - Willingham, Mark C AU - Onda, Masanori AU - Hassan, Raffit AU - FitzGerald, David AU - Pastan, Ira AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA. Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 SP - 1571 EP - 1575 VL - 13 IS - 5 SN - 1078-0432, 1078-0432 KW - Antibodies, Monoclonal KW - 0 KW - GPI-Linked Proteins KW - Membrane Glycoproteins KW - RNA, Messenger KW - SS1(dsFv)PE38 KW - mesothelin KW - Index Medicus KW - Blotting, Western KW - Humans KW - RNA, Messenger -- analysis KW - Flow Cytometry KW - Cell Line, Tumor KW - Antibodies, Monoclonal -- pharmacology KW - Reverse Transcriptase Polymerase Chain Reaction KW - Immunohistochemistry KW - Membrane Glycoproteins -- drug effects KW - Adenocarcinoma -- metabolism KW - Membrane Glycoproteins -- biosynthesis KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70226107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Mesothelin+expression+in+human+lung+cancer.&rft.au=Ho%2C+Mitchell%3BBera%2C+Tapan+K%3BWillingham%2C+Mark+C%3BOnda%2C+Masanori%3BHassan%2C+Raffit%3BFitzGerald%2C+David%3BPastan%2C+Ira&rft.aulast=Ho&rft.aufirst=Mitchell&rft.date=2007-03-01&rft.volume=13&rft.issue=5&rft.spage=1571&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-09 N1 - Date created - 2007-03-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mechanisms of disease: Environmental factors in the pathogenesis of rheumatic disease. AN - 70225885; 17334340 AB - Most rheumatic diseases are complex disorders for which pathogenetic mechanisms are poorly understood. Nonetheless, increasing evidence suggests that many of these illnesses result from one or more specific environmental exposures in genetically susceptible individuals. Although much progress has been made over the past few decades in advancing our knowledge of the genetics of rheumatic diseases, few studies have assessed environmental features and understanding of which exposures are important in pathogenesis remains limited. In this article, we review the difficulties inherent in deciphering the interacting environmental and genetic risk factors for rheumatic diseases, the current state of knowledge of infectious and noninfectious risk factors, possible mechanisms by which environmental exposures might induce pathologic processes and future directions. The advances in technologies and statistical approaches, development of collaborating consortia and focused resources that have resulted in the explosion of genetic information must now be applied to environmental studies so we can eventually interrupt pathogenesis before the onset of disease and transform the practice of medicine from curative to pre-emptive paradigms. JF - Nature clinical practice. Rheumatology AU - Gourley, Mark AU - Miller, Frederick W AD - Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, NIH, Bethesda, MD 20892-1301, USA. gourleym@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 172 EP - 180 VL - 3 IS - 3 SN - 1745-8382, 1745-8382 KW - Index Medicus KW - Odds Ratio KW - Multifactorial Inheritance -- immunology KW - Infection -- immunology KW - Risk Factors KW - Humans KW - Infection -- complications KW - Rheumatic Diseases -- immunology KW - Rheumatic Diseases -- genetics KW - Environmental Exposure -- adverse effects KW - Rheumatic Diseases -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70225885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+clinical+practice.+Rheumatology&rft.atitle=Mechanisms+of+disease%3A+Environmental+factors+in+the+pathogenesis+of+rheumatic+disease.&rft.au=Gourley%2C+Mark%3BMiller%2C+Frederick+W&rft.aulast=Gourley&rft.aufirst=Mark&rft.date=2007-03-01&rft.volume=3&rft.issue=3&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=Nature+clinical+practice.+Rheumatology&rft.issn=17458382&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-22 N1 - Date created - 2007-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cyclooxygenase-2 inhibits UVB-induced apoptosis in mouse skin by activating the prostaglandin E2 receptors, EP2 and EP4. AN - 70224314; 17332329 AB - Cyclooxygenase-2 (COX-2) is induced by UVB light and reduces UVB-induced epidermal apoptosis; however, the mechanism is unclear. Therefore, wild-type (WT) and COX-2-/- mice were acutely treated with UVB (5 kJ/m(2)), and apoptotic signaling pathways were compared. Following exposure, apoptosis was 2.5-fold higher in COX-2-/- compared with WT mice. Because prostaglandin E(2) (PGE(2)) is the major UV-induced prostaglandin and manifests its activity via four receptors, EP1 to EP4, possible differences in EP signaling were investigated in WT and COX-2-/- mice. Following UVB exposure, protein levels of EP1, EP2, and EP4 were elevated in WT mice, but EP2 and EP4 levels were 50% lower in COX-2-/- mice. Activated cyclic AMP-dependent protein kinase (PKA) and Akt are downstream in EP2 and EP4 signaling, and their levels were reduced in UVB-exposed COX-2-/- mice. Furthermore, p-Bad (Ser(136) and Ser(155)), antiapoptotic products of activated Akt and PKA, respectively, were significantly reduced in UVB-exposed COX-2-/- mice. To further study the roles of EP2 and EP4, UVB-exposed CD-1 mice were topically treated with indomethacin to block endogenous PGE(2) production, and PGE(2), the EP2 agonist (butaprost) or EP4 agonist (PGE(1) alcohol), was applied. Indomethacin reduced PKA and Akt activation by approximately 60%, but PGE(2) and the agonists restored their activities. Furthermore, both agonists decreased apoptosis in COX-2-/- mice by 50%. The data suggest that COX-2-generated PGE(2) has antiapoptotic roles in UVB-exposed mouse skin that involves EP2- and EP4-mediated signaling. JF - Cancer research AU - Chun, Kyung-Soo AU - Akunda, Jacqueline K AU - Langenbach, Robert AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences/NIH, Research Triangle Park, NC 27709, USA. Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 SP - 2015 EP - 2021 VL - 67 IS - 5 SN - 0008-5472, 0008-5472 KW - Bad protein, mouse KW - 0 KW - Ptger2 protein, mouse KW - Ptger4 protein, mouse KW - Receptors, Prostaglandin E KW - Receptors, Prostaglandin E, EP2 Subtype KW - Receptors, Prostaglandin E, EP4 Subtype KW - Tumor Suppressor Protein p53 KW - bcl-2-Associated X Protein KW - bcl-Associated Death Protein KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - Dinoprostone KW - K7Q1JQR04M KW - Index Medicus KW - Animals KW - Dinoprostone -- physiology KW - Mice KW - Models, Biological KW - Tumor Suppressor Protein p53 -- metabolism KW - bcl-Associated Death Protein -- metabolism KW - Mice, Knockout KW - bcl-2-Associated X Protein -- metabolism KW - Mice, Inbred Strains KW - Mice, Inbred C57BL KW - Female KW - Receptors, Prostaglandin E -- metabolism KW - Cyclooxygenase 2 -- physiology KW - Ultraviolet Rays KW - Skin -- radiation effects KW - Skin -- enzymology KW - Cyclooxygenase 2 -- genetics KW - Skin -- metabolism KW - Apoptosis -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70224314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Cyclooxygenase-2+inhibits+UVB-induced+apoptosis+in+mouse+skin+by+activating+the+prostaglandin+E2+receptors%2C+EP2+and+EP4.&rft.au=Chun%2C+Kyung-Soo%3BAkunda%2C+Jacqueline+K%3BLangenbach%2C+Robert&rft.aulast=Chun&rft.aufirst=Kyung-Soo&rft.date=2007-03-01&rft.volume=67&rft.issue=5&rft.spage=2015&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-12 N1 - Date created - 2007-03-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Dev Cell. 2002 Nov;3(5):607-8 [12431365] Toxicol Appl Pharmacol. 2004 Mar 15;195(3):298-308 [15020192] J Biol Chem. 2003 Apr 11;278(15):12752-8 [12556459] J Am Soc Nephrol. 2003 Jun;14(6):1427-34 [12761242] Mol Carcinog. 2003 Jul;37(3):149-57 [12884366] Cancer Res. 2003 Sep 1;63(17):5239-42 [14500353] Life Sci. 2003 Dec 5;74(2-3):143-53 [14607241] J Invest Dermatol. 2003 Oct;121(4):853-61 [14632205] Mol Carcinog. 2007 May;46(5):354-62 [17238138] J Clin Invest. 1990 Aug;86(2):566-74 [1696589] Cancer Cells. 1991 Jan;3(1):8-12 [2025494] Nature. 1993 Apr 29;362(6423):847-9 [8479522] Nature. 1993 Apr 29;362(6423):849-52 [8479523] Cell. 1995 Nov 3;83(3):493-501 [8521479] Crit Rev Biochem Mol Biol. 1996 Dec;31(5-6):381-404 [8994803] J Invest Dermatol. 1997 Dec;109(6):722-7 [9406811] Cancer Res. 1998 Jan 15;58(2):362-6 [9443418] Carcinogenesis. 1998 May;19(5):723-9 [9635856] Curr Opin Cell Biol. 1998 Dec;10(6):791-7 [9914179] J Biol Chem. 1999 Apr 16;274(16):10911-5 [10196169] Biochem Pharmacol. 1999 Oct 15;58(8):1237-46 [10487525] Oncogene. 2005 Feb 24;24(9):1634-40 [15608668] Mol Cancer Res. 2005 Feb;3(2):90-9 [15755875] Cancer Res. 2005 May 1;65(9):3853-60 [15867384] Int J Cancer. 2005 Oct 10;116(6):847-52 [15856465] J Biol Chem. 2005 Sep 16;280(37):32379-88 [16046401] J Invest Dermatol. 2005 Oct;125(4):818-25 [16185283] Oncol Rep. 2006 Feb;15(2):471-7 [16391871] J Invest Dermatol. 2006 Jan;126(1):205-11 [16417238] Cancer Res. 2006 Jul 15;66(14):7059-66 [16849551] J Invest Dermatol. 2007 Jan;127(1):214-21 [16917495] Cancer Res. 2002 Nov 1;62(21):6323-8 [12414664] J Environ Pathol Toxicol Oncol. 2002;21(2):183-91 [12086405] Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4361-6 [11904361] J Biol Chem. 2002 Jan 11;277(2):1340-8 [11694504] Annu Rev Pharmacol Toxicol. 2001;41:661-90 [11264472] Biochem J. 2000 Jul 15;349(Pt 2):547-57 [10880354] Annu Rev Biochem. 2000;69:145-82 [10966456] Redox Rep. 2000;5(2-3):128-9 [10939292] Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9215-20 [10908664] Annu Rev Biochem. 1999;68:821-61 [10872467] Genes Dev. 1999 Nov 15;13(22):2905-27 [10579998] Am J Physiol Gastrointest Liver Physiol. 2003 Mar;284(3):G490-8 [12431904] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inhibiting pollen reduced nicotinamide adenine dinucleotide phosphate oxidase-induced signal by intrapulmonary administration of antioxidants blocks allergic airway inflammation. AN - 70222252; 17336614 AB - Ragweed extract (RWE) contains NADPH oxidases that induce oxidative stress in the airways independent of adaptive immunity (signal 1) and augment antigen (signal 2)-induced allergic airway inflammation. To test whether inhibiting signal 1 by administering antioxidants inhibits allergic airway inflammation in mice. The ability of ascorbic acid (AA), N-acetyl cystenine (NAC), and tocopherol to scavenge pollen NADPH oxidase-generated reactive oxygen species (ROS) was measured. These antioxidants were administered locally to inhibit signal 1 in the airways of RWE-sensitized mice. Recruitment of inflammatory cells, mucin production, calcium-activated chloride channel 3, IL-4, and IL-13 mRNA expression was quantified in the lungs. Antioxidants inhibited ROS generation by pollen NADPH oxidases and intracellular ROS generation in cultured epithelial cells. AA in combination with NAC or Tocopherol decreased RWE-induced ROS levels in cultured bronchial epithelial cells. Coadministration of antioxidants with RWE challenge inhibited 4-hydroxynonenal adduct formation, upregulation of Clca3 and IL-4 in lungs, mucin production, recruitment of eosinophils, and total inflammatory cells into the airways. Administration of antioxidants with a second RWE challenge also inhibited airway inflammation. However, administration of AA+NAC 4 or 24 hours after RWE challenge failed to inhibit allergic inflammation. Signal 1 plays a proinflammatory role during repeated exposure to pollen extract. We propose that inhibiting signal 1 by increasing antioxidant potential in the airways may be a novel therapeutic strategy to attenuate pollen-induced allergic airway inflammation. Administration of antioxidants in the airways may constitute a novel therapeutic strategy to prevent pollen induced allergic airway inflammation. JF - The Journal of allergy and clinical immunology AU - Dharajiya, Nilesh AU - Choudhury, Barun K AU - Bacsi, Attila AU - Boldogh, Istvan AU - Alam, Rafeul AU - Sur, Sanjiv AD - National Heart, Lung, and Blood Institute Proteomics Center, University of Texas Medical Branch, Division of Allergy and Immunology, Department of Internal Medicine, Galveston, Texas, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 646 EP - 653 VL - 119 IS - 3 SN - 0091-6749, 0091-6749 KW - Antioxidants KW - 0 KW - Chloride Channels KW - Interleukin-13 KW - Mucins KW - Plant Extracts KW - Reactive Oxygen Species KW - Tocopherols KW - 1406-66-2 KW - Interleukin-4 KW - 207137-56-2 KW - Nitrate Reductase (NAD(P)H) KW - EC 1.7.1.2 KW - Ascorbic Acid KW - PQ6CK8PD0R KW - Acetylcysteine KW - WYQ7N0BPYC KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Ascorbic Acid -- administration & dosage KW - Chloride Channels -- analysis KW - Interleukin-13 -- metabolism KW - Acetylcysteine -- administration & dosage KW - Lung -- chemistry KW - Chloride Channels -- metabolism KW - Mice KW - Lung -- immunology KW - Interleukin-4 -- metabolism KW - Mucins -- analysis KW - Interleukin-4 -- analysis KW - Mucins -- metabolism KW - Tocopherols -- administration & dosage KW - Reactive Oxygen Species -- antagonists & inhibitors KW - Plant Extracts -- toxicity KW - Interleukin-13 -- analysis KW - Administration, Inhalation KW - Pollen -- enzymology KW - Bronchitis -- prevention & control KW - Nitrate Reductase (NAD(P)H) -- antagonists & inhibitors KW - Pollen -- immunology KW - Hypersensitivity -- prevention & control KW - Nitrate Reductase (NAD(P)H) -- toxicity KW - Antioxidants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70222252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=Inhibiting+pollen+reduced+nicotinamide+adenine+dinucleotide+phosphate+oxidase-induced+signal+by+intrapulmonary+administration+of+antioxidants+blocks+allergic+airway+inflammation.&rft.au=Dharajiya%2C+Nilesh%3BChoudhury%2C+Barun+K%3BBacsi%2C+Attila%3BBoldogh%2C+Istvan%3BAlam%2C+Rafeul%3BSur%2C+Sanjiv&rft.aulast=Dharajiya&rft.aufirst=Nilesh&rft.date=2007-03-01&rft.volume=119&rft.issue=3&rft.spage=646&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=00916749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-12 N1 - Date created - 2007-03-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Chest. 2001 Oct;120(4):1136-9 [11591550] Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5175-80 [11296262] Am J Respir Crit Care Med. 2002 Apr 15;165(8):1132-6 [11956057] Toxicol In Vitro. 2002 Jun;16(3):209-18 [12020593] Science. 2002 Dec 6;298(5600):1911-2 [12471242] Inflamm Res. 2003 Mar;52(3):126-31 [12755377] Am J Physiol Lung Cell Mol Physiol. 2003 Sep;285(3):L671-9 [12730081] Clin Exp Allergy. 2003 Oct;33(10):1355-9 [14519140] Biochem Biophys Res Commun. 1990 Jun 29;169(3):851-7 [2114108] Am Rev Respir Dis. 1992 Nov;146(5 Pt 1):1161-6 [1443865] J Lab Clin Med. 1994 Jan;123(1):131-6 [8288953] J Allergy Clin Immunol. 1996 Jun;97(6):1272-8 [8648023] Allergy. 1995 Nov;50(11):891-8 [8748721] Am J Respir Crit Care Med. 1996 Oct;154(4 Pt 1):1055-60 [8887607] J Immunol. 1996 Nov 1;157(9):4173-80 [8892655] Free Radic Biol Med. 1997;22(1-2):269-85 [8958153] J Immunol. 1997 May 15;158(10):4953-60 [9144514] Am J Respir Cell Mol Biol. 1997 Dec;17(6):702-12 [9409557] Free Radic Biol Med. 1998 Apr;24(6):952-8 [9607605] J Lipid Res. 1998 Aug;39(8):1529-42 [9717713] Genomics. 1998 Dec 1;54(2):200-14 [9828122] Science. 1998 Dec 18;282(5397):2261-3 [9856950] Biochem Biophys Res Commun. 1999 Feb 16;255(2):347-51 [10049711] J Immunol. 1999 May 15;162(10):6233-7 [10229869] J Immunol. 1999 May 15;162(10):6284-93 [10229876] Lancet. 1999 Aug 7;354(9177):482-3 [10465176] J Clin Invest. 2005 Aug;115(8):2169-79 [16075057] J Allergy Clin Immunol. 2005 Oct;116(4):836-43 [16210058] Am J Physiol Lung Cell Mol Physiol. 2005 Nov;289(5):L724-30 [15749742] Curr Opin Immunol. 2000 Feb;12(1):64-76 [10679404] Can Respir J. 2000 Nov-Dec;7(6):476-80 [11121092] Am J Respir Crit Care Med. 2001 Feb;163(2):517-23 [11179133] J Immunol. 2001 May 1;166(9):5763-72 [11313420] J Immunol. 2002 Jan 15;168(2):846-52 [11777981] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Assessment of birth defects according to maternal therapy among infants in the Women and Infants Transmission Study. AN - 70221585; 17159659 AB - To evaluate rate and types of birth defects according to timing of antiretroviral exposure among babies born to HIV-infected women. Anomalies identified during the prenatal, neonatal, or follow-up period were classified using criteria of the Antiretroviral Pregnancy Registry. Antiretroviral use was classified as none, second or third trimester only, or first trimester. From January 1, 1990 through June 30, 2004, 2527 live births (LBs) occurred to 2353 women. Defects were identified in 90 babies for a rate of 3.56 defects per 100 LBs. The rate of defects was 3.19 per 100 LBs (24 of 752 LBs) with first-trimester antiretroviral exposure, 3.54 per 100 LBs (41 of 1158 LBs) with exposure later in pregnancy, and 4.05 of 100 LBs (25 of 617 LBs) with no antiretroviral use. Only genital abnormalities, specifically hypospadias, were significantly increased among babies born to women with first-trimester exposure to antiretrovirals (7 of 382 male LBs) compared with the 2 other groups (2 of 892 male LBs; P = 0.007). On logistic regression, use of zidovudine in the first trimester was associated with hypospadias (adjusted odds ratio = 10.68, 95% confidence interval: 2.11 to 54.13; P = 0.004). In general, data were reassuring, although the frequency of exposure to newer agents was limited. The increased risk of hypospadias after first-trimester exposure must be explored, because this association has not been detected previously. JF - Journal of acquired immune deficiency syndromes (1999) AU - Watts, D Heather AU - Li, Daner AU - Handelsman, Ed AU - Tilson, Hugh AU - Paul, Mary AU - Foca, Marc AU - Vajaranant, Mark AU - Diaz, Clemente AU - Tuomala, Ruth AU - Thompson, Bruce AD - Pediatric, Adolescent, and Maternal AIDS Branch, Center for Research on Mothers and Infants, National Institute of Child Health and Human Development/NIH, 6100 Executive Boulevard, Bethesda, MD 20892, USA. heather.watts@nih.hhs.gov Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 SP - 299 EP - 305 VL - 44 IS - 3 SN - 1525-4135, 1525-4135 KW - Anti-HIV Agents KW - 0 KW - Index Medicus KW - AIDS/HIV KW - Infant KW - Humans KW - Adult KW - Female KW - Pregnancy KW - Abnormalities, Drug-Induced KW - Anti-HIV Agents -- therapeutic use KW - HIV Infections -- drug therapy KW - Anti-HIV Agents -- adverse effects KW - Pregnancy Complications, Infectious -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70221585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.atitle=Assessment+of+birth+defects+according+to+maternal+therapy+among+infants+in+the+Women+and+Infants+Transmission+Study.&rft.au=Watts%2C+D+Heather%3BLi%2C+Daner%3BHandelsman%2C+Ed%3BTilson%2C+Hugh%3BPaul%2C+Mary%3BFoca%2C+Marc%3BVajaranant%2C+Mark%3BDiaz%2C+Clemente%3BTuomala%2C+Ruth%3BThompson%2C+Bruce&rft.aulast=Watts&rft.aufirst=D&rft.date=2007-03-01&rft.volume=44&rft.issue=3&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.issn=15254135&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-05 N1 - Date created - 2007-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lithium-methomyl induced seizures in rats: a new model of status epilepticus? AN - 70216366; 17092527 AB - Behavioral, electroencephalographic (EEG) and neuropathological effects of methomyl, a carbamate insecticide reversibly inhibiting acetylcholinesterase activity, were studied in naive or lithium chloride (24 h, 3 mEq/kg, s.c.) pretreated male Wistar rats. In naive animals, methomyl with equal potency produced motor limbic seizures and fatal status epilepticus. Thus, the CD50 values (50% convulsant dose) for these seizure endpoints were almost equal to the LD50 (50% lethal dose) of methomyl (13 mg/kg). Lithium pretreated rats were much more susceptible to convulsant, but not lethal effect of methomyl. CD50 values of methomyl for motor limbic seizures and status epilepticus were reduced by lithium pretreatment to 3.7 mg/kg (a 3.5-fold decrease) and 5.2 mg/kg (a 2.5-fold decrease), respectively. In contrast, lithium pretreatment resulted in only 1.3-fold decrease of LD50 value of methomyl (9.9 mg/kg). Moreover, lithium-methomyl treated animals developed a long-lasting status epilepticus, which was not associated with imminent lethality observed in methomyl-only treated rats. Scopolamine (10 mg/kg) or diazepam (10 mg/kg) protected all lithium-methomyl treated rats from convulsions and lethality. Cortical and hippocampal EEG recordings revealed typical epileptic discharges that were consistent with behavioral seizures observed in lithium-methomyl treated rats. In addition, convulsions induced by lithium-methomyl treatment were associated with widespread neurodegeneration of limbic structures. Our observations indicate that lithium pretreatment results in separation between convulsant and lethal effects of methomyl in rats. As such, seizures induced by lithium-methomyl administration may be an alternative to lithium-pilocarpine model of status epilepticus, which is associated with high lethality. JF - Toxicology and applied pharmacology AU - Kaminski, Rafal M AU - Blaszczak, Piotr AU - Dekundy, Andrzej AU - Parada-Turska, Jolanta AU - Calderazzo, Lineu AU - Cavalheiro, Esper A AU - Turski, Waldemar A AD - Department of Toxicology, Institute of Agricultural Medicine, Jaczewskiego 2, 20-950 Lublin, Poland. kaminskr@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 122 EP - 127 VL - 219 IS - 2-3 SN - 0041-008X, 0041-008X KW - Anticonvulsants KW - 0 KW - Methomyl KW - 1NQ08HN02S KW - Scopolamine Hydrobromide KW - 451IFR0GXB KW - Lithium Chloride KW - G4962QA067 KW - Diazepam KW - Q3JTX2Q7TU KW - Index Medicus KW - Rats KW - Animals KW - Diazepam -- therapeutic use KW - Electroencephalography KW - Rats, Wistar KW - Scopolamine Hydrobromide -- therapeutic use KW - Drug Synergism KW - Anticonvulsants -- therapeutic use KW - Male KW - Seizures -- chemically induced KW - Status Epilepticus -- chemically induced KW - Lithium Chloride -- toxicity KW - Disease Models, Animal KW - Seizures -- prevention & control KW - Methomyl -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70216366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Lithium-methomyl+induced+seizures+in+rats%3A+a+new+model+of+status+epilepticus%3F&rft.au=Kaminski%2C+Rafal+M%3BBlaszczak%2C+Piotr%3BDekundy%2C+Andrzej%3BParada-Turska%2C+Jolanta%3BCalderazzo%2C+Lineu%3BCavalheiro%2C+Esper+A%3BTurski%2C+Waldemar+A&rft.aulast=Kaminski&rft.aufirst=Rafal&rft.date=2007-03-01&rft.volume=219&rft.issue=2-3&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-29 N1 - Date created - 2007-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Diagnostic potential for urinary proteomics. AN - 70214578; 17324112 AB - Urine represents a modified ultrafiltrate of plasma, with protein concentrations typically approximately 1000-fold lower than plasma. Urine's low protein concentration might suggest it to be a less promising diagnostic specimen than plasma. However, urine can be obtained noninvasively and tests of many urinary proteins are well-established in clinical practice. Proteomic technologies expand opportunities to analyze urinary proteins, identifying more than 1000 proteins and peptides in urine. Urine offers a sampling of most plasma proteins, with increased proportions of low-molecular-weight protein and peptide components. Urine also offers enriched sampling of proteins released along the urinary tract. Although urine presents some challenges as a diagnostic specimen, its diverse range of potential markers offers great potential for diagnosis of both systemic and kidney diseases. Examples of clinical situations where this may be of value are for more sensitive detection of kidney transplant rejection or of renal toxicity of medications. JF - Pharmacogenomics AU - Hortin, Glen L AU - Sviridov, Denis AD - National Institutes of Health, Department of Laboratory Medicine, Warren Magnuson Clinical Center, Building 10, Room 2C-407, Bethesda, MD 20892-1508, USA. ghortin@mail.cc.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 237 EP - 255 VL - 8 IS - 3 KW - Biomarkers KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Proteomics -- methods KW - Proteinuria -- urine KW - Urologic Diseases -- urine KW - Biomarkers -- urine KW - Urologic Diseases -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70214578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenomics&rft.atitle=Diagnostic+potential+for+urinary+proteomics.&rft.au=Hortin%2C+Glen+L%3BSviridov%2C+Denis&rft.aulast=Hortin&rft.aufirst=Glen&rft.date=2007-03-01&rft.volume=8&rft.issue=3&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=Pharmacogenomics&rft.issn=1744-8042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-03 N1 - Date created - 2007-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pesticide exposure and self-reported gestational diabetes mellitus in the Agricultural Health Study. AN - 70214542; 17327316 AB - To examine the association between pesticide use during pregnancy and gestational diabetes mellitus (GDM) among wives of licensed pesticide applicators. Using data from the Agricultural Health Study (AHS), we estimated the association between self-reported pesticide-related activities during the first trimester of the most recent pregnancy and GDM among 11,273 women whose pregnancy occurred within 25 years of enrollment. A total of 506 (4.5%) women reported having had GDM. Women who reported agricultural pesticide exposure (mixing or applying pesticides to crops or repairing pesticide application equipment) during pregnancy were more likely to report GDM (odds ratio [OR] 2.2 [95% CI 1.5-3.3]). We saw no association between residential pesticide exposure (applying pesticides in the home and garden during pregnancy) and GDM (1.0 [0.8-1.3]). Among women who reported agricultural exposure during pregnancy, risk of GDM was associated with ever-use of four herbicides (2,4,5-T; 2,4,5-TP; atrazine; or butylate) and three insecticides (diazinon, phorate, or carbofuran). These findings suggest that activities involving exposure to agricultural pesticides during the first trimester of pregnancy may increase the risk of GDM. JF - Diabetes care AU - Saldana, Tina M AU - Basso, Olga AU - Hoppin, Jane A AU - Baird, Donna D AU - Knott, Charles AU - Blair, Aaron AU - Alavanja, Michael C R AU - Sandler, Dale P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, P.O. Box 12233, MD A3-05, Research Triangle Park, NC 27709, USA. saldana@niehs.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 529 EP - 534 VL - 30 IS - 3 KW - Pesticides KW - 0 KW - Index Medicus KW - Parity KW - Educational Status KW - Humans KW - Continental Population Groups KW - Body Mass Index KW - North Carolina -- epidemiology KW - Smoking -- epidemiology KW - Pregnancy KW - Maternal Age KW - Adult KW - Surveys and Questionnaires KW - Middle Aged KW - Adolescent KW - Female KW - Iowa -- epidemiology KW - Agriculture KW - Diabetes, Gestational -- etiology KW - Diabetes, Gestational -- epidemiology KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70214542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes+care&rft.atitle=Pesticide+exposure+and+self-reported+gestational+diabetes+mellitus+in+the+Agricultural+Health+Study.&rft.au=Saldana%2C+Tina+M%3BBasso%2C+Olga%3BHoppin%2C+Jane+A%3BBaird%2C+Donna+D%3BKnott%2C+Charles%3BBlair%2C+Aaron%3BAlavanja%2C+Michael+C+R%3BSandler%2C+Dale+P&rft.aulast=Saldana&rft.aufirst=Tina&rft.date=2007-03-01&rft.volume=30&rft.issue=3&rft.spage=529&rft.isbn=&rft.btitle=&rft.title=Diabetes+care&rft.issn=1935-5548&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-27 N1 - Date created - 2007-02-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Sci. 2000 Aug;56(2):431-6 [10911003] Comp Biochem Physiol C Toxicol Pharmacol. 2004 Apr;137(4):343-7 [15228952] Hum Reprod Update. 2001 May-Jun;7(3):331-9 [11392380] Epidemiology. 2002 Jan;13(1):94-9 [11805592] J Expo Anal Environ Epidemiol. 2002 Sep;12(5):313-8 [12198579] Environ Health Perspect. 2002 Sep;110(9):853-8 [12204817] Environ Health Perspect. 2003 May;111(5):724-30 [12727601] J Nutr. 2003 May;133(5 Suppl 2):1674S-1683S [12730484] Diabet Med. 2004 Feb;21(2):103-13 [14984444] Arch Med Res. 2004 May-Jun;35(3):241-5 [15163467] J Cell Sci. 1998 Nov;111 ( Pt 22):3311-22 [9788873] J Occup Environ Med. 2004 Aug;46(8):856-65 [15300138] Am J Med. 1971 Apr;50(4):475-92 [4324629] S Afr Med J. 1978 Aug 5;54(6):230-4 [715598] Diabetes. 1979 Dec;28(12):1039-57 [510803] J Environ Sci Health B. 1992 Oct;27(5):495-510 [1401727] Epidemiology. 1993 Jan;4(1):55-62 [8420582] Environ Health Perspect. 1996 Apr;104(4):362-9 [8732939] Diabetes Care. 1996 Jan;19(1):12-6 [8720526] Epidemiology. 1997 May;8(3):252-8 [9115019] Diabetes Care. 1998 Aug;21 Suppl 2:B9-13 [9704221] Am J Ind Med. 1998 Dec;34(6):581-7 [9816416] Occup Environ Med. 1999 Apr;56(4):270-6 [10450245] J Clin Invest. 2005 Mar;115(3):485-91 [15765129] J Clin Epidemiol. 2006 Apr;59(4):429-35 [16549266] Epidemiology. 2000 Jan;11(1):44-8 [10615842] Metabolism. 1999 Nov;48(11):1461-9 [10582558] J Assoc Physicians India. 2000 Dec;48(12):1197-9 [11280228] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Methodological issues regarding confounding and exposure misclassification in epidemiological studies of occupational exposures. AN - 70207258; 17096363 AB - Confounding and exposure misclassification are issues that concern epidemiologists because of their potential to bias results of studies and complicate interpretations. In occupational epidemiology both are routinely raised to argue that an observed result is either a false positive or a false negative finding. Although it is important to consider the potential for limitations of epidemiologic investigations, judgment regarding their importance should be based on their actual likelihood of occurrence. This paper is based on our experience in epidemiologic analyses and a brief review of the literature regarding confounding and exposure misclassification. Examples of substantial confounding are rare in occupational epidemiology. In fact, even for studies of occupational exposures and lung cancer, tobacco-adjusted relative risks rarely differ appreciably from the unadjusted estimates. This is surprising because it seems the perfect situation for confounding to occur. Yet, despite the lack of evidence that confounding is a common problem, nearly every epidemiologic paper includes a lengthy discussion on uncontrolled or residual confounding. On the other hand, exposure misclassification probably occurs in all studies. The only question is, how much? The direction and magnitude of nondifferential exposure misclassification (the type most likely to occur in cohort studies) on estimates of relative risks can be largely predicted given knowledge on the degree of misclassification, that is, relatively small amounts of misclassification can bias relative risks substantially towards the null. The literature, however, is full of discussions implying that misclassification of exposure is an explanation for a positive finding. These comments are not to suggest that all potential limitations for epidemiologic studies should not be considered and evaluated. We do believe, however, that the likelihood of occurrence and the direction and magnitude of the effect should be more carefully and realistically considered when making judgments about study design or data interpretation. (c) 2007 Wiley-Liss, Inc. JF - American journal of industrial medicine AU - Blair, Aaron AU - Stewart, Patricia AU - Lubin, Jay H AU - Forastiere, Francesco AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20892, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 199 EP - 207 VL - 50 IS - 3 SN - 0271-3586, 0271-3586 KW - Index Medicus KW - Odds Ratio KW - Age Factors KW - Lung Neoplasms -- epidemiology KW - Humans KW - Smoking -- adverse effects KW - Bias (Epidemiology) KW - Risk KW - Occupational Exposure -- statistics & numerical data KW - Confounding Factors (Epidemiology) KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70207258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Methodological+issues+regarding+confounding+and+exposure+misclassification+in+epidemiological+studies+of+occupational+exposures.&rft.au=Blair%2C+Aaron%3BStewart%2C+Patricia%3BLubin%2C+Jay+H%3BForastiere%2C+Francesco&rft.aulast=Blair&rft.aufirst=Aaron&rft.date=2007-03-01&rft.volume=50&rft.issue=3&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-29 N1 - Date created - 2007-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Epidermal growth factor receptor inhibitors: a new era of drug reactions in a new era of cancer therapy. AN - 70206692; 17184876 JF - Journal of the American Academy of Dermatology AU - Cowen, Edward W AD - Dermatology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. cowene@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 514 EP - 517 VL - 56 IS - 3 KW - Antineoplastic Agents KW - 0 KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Isotretinoin KW - EH28UP18IF KW - Index Medicus KW - Humans KW - Isotretinoin -- therapeutic use KW - Receptor, Epidermal Growth Factor -- antagonists & inhibitors KW - Drug Eruptions -- etiology KW - Drug Eruptions -- drug therapy KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70206692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Journal+of+the+American+Academy+of+Dermatology&rft.atitle=Epidermal+growth+factor+receptor+inhibitors%3A+a+new+era+of+drug+reactions+in+a+new+era+of+cancer+therapy.&rft.au=Cowen%2C+Edward+W&rft.aulast=Cowen&rft.aufirst=Edward&rft.date=2007-03-01&rft.volume=56&rft.issue=3&rft.spage=514&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Dermatology&rft.issn=1097-6787&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-13 N1 - Date created - 2007-02-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: J Am Acad Dermatol. 2007 Mar;56(3):500-5 [17166623] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - CAR and PXR: the xenobiotic-sensing receptors. AN - 69039437; 17284330 AB - The xenobiotic receptors CAR and PXR constitute two important members of the NR1I nuclear receptor family. They function as sensors of toxic byproducts derived from endogenous metabolism and of exogenous chemicals, in order to enhance their elimination. This unique function of CAR and PXR sets them apart from the steroid hormone receptors. In contrast, the steroid receptors, exemplified by the estrogen receptor (ER) and glucocorticoid receptor (GR), are the sensors that tightly monitor and respond to changes in circulating steroid hormone levels to maintain body homeostasis. This divergence of the chemical- and steroid-sensing functions has evolved to ensure the fidelity of the steroid hormone endocrine regulation while allowing development of metabolic elimination pathways for xenobiotics. The development of the xenobiotic receptors CAR and PXR also reflect the increasing complexity of metabolism in higher organisms, which necessitate novel mechanisms for handling and eliminating metabolic by-products and foreign compounds from the body. The purpose of this review is to discuss similarities and differences between the xenobiotic receptors CAR and PXR with the prototypical steroid hormone receptors ER and GR. Interesting differences in structure explain in part the divergence in function and activation mechanisms of CAR/PXR from ER/GR. In addition, the physiological roles of CAR and PXR will be reviewed, with discussion of interactions of CAR and PXR with endocrine signaling pathways. JF - Steroids AU - Timsit, Yoav E AU - Negishi, Masahiko AD - Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 231 EP - 246 VL - 72 IS - 3 SN - 0039-128X, 0039-128X KW - Ligands KW - 0 KW - Receptors, Cytoplasmic and Nuclear KW - Receptors, Steroid KW - Transcription Factors KW - Xenobiotics KW - constitutive androstane receptor KW - pregnane X receptor KW - Cytochrome P-450 CYP3A KW - EC 1.14.14.1 KW - Index Medicus KW - Rats KW - Molecular Structure KW - Animals KW - Inactivation, Metabolic KW - Humans KW - Cytochrome P-450 CYP3A -- metabolism KW - Mice KW - Signal Transduction KW - Protein Transport KW - Protein Conformation KW - Transcription Factors -- metabolism KW - Xenobiotics -- metabolism KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Receptors, Steroid -- metabolism KW - Xenobiotics -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69039437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Steroids&rft.atitle=CAR+and+PXR%3A+the+xenobiotic-sensing+receptors.&rft.au=Timsit%2C+Yoav+E%3BNegishi%2C+Masahiko&rft.aulast=Timsit&rft.aufirst=Yoav&rft.date=2007-03-01&rft.volume=72&rft.issue=3&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=Steroids&rft.issn=0039128X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-14 N1 - Date created - 2007-02-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 2000 May;20(9):2951-8 [10757780] Biochem Biophys Res Commun. 2000 Aug 11;274(3):707-13 [10924340] Mol Cell. 2000 Jul;6(1):127-37 [10949034] Mol Endocrinol. 2000 Nov;14(11):1897-905 [11075820] Nat Cell Biol. 2001 Jan;3(1):93-6 [11146632] Steroids. 2005 May-Jun;70(5-7):361-3 [15862818] Steroids. 2005 May-Jun;70(5-7):407-17 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Biochemistry. 2006 Jul 18;45(28):8579-89 [16834332] Biochem J. 2006 Aug 15;398(1):125-33 [16623664] Mini Rev Med Chem. 2006 Aug;6(8):937-47 [16918499] Mol Endocrinol. 2006 Sep;20(9):1996-2009 [16645038] Mol Cell Biol. 2006 Nov;26(21):7966-76 [16940184] Mol Endocrinol. 2006 Dec;20(12):3120-32 [16945990] J Mol Graph Model. 2007 Jan;25(5):644-57 [16831563] Endocr Rev. 2002 Oct;23(5):687-702 [12372848] Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):223-8 [12509506] Biochim Biophys Acta. 2003 Feb 17;1619(3):243-53 [12573484] Biochemistry. 2003 Feb 18;42(6):1430-8 [12578355] J Biol Chem. 2003 Mar 28;278(13):11344-50 [12551939] J Steroid Biochem Mol Biol. 2002 Dec;83(1-5):37-48 [12650700] Mol Endocrinol. 2005 May;19(5):1170-80 [15650019] Mol Endocrinol. 2005 May;19(5):1125-34 [15705662] J Biol Chem. 1999 Nov 19;274(47):33551-6 [10559241] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lessons learned from the Children's Environmental Exposure Research Study. AN - 69033863; 17267718 AB - We examined 5 different ethical concerns about the Children's Environmental Exposure Research Study and make some recommendations for future studies of exposure to hazardous environmental agents in the home. Researchers should seek community consultation and participation; make participants aware of all the risks associated with the research, including hazards discovered in the home and uncertainties about the risks of agents under investigation; and take steps to ensure that their studies will not have unfair representation of the poor or people of color. Researchers should also avoid even the appearance of a financial conflict of interest in studies that are likely to be controversial and make it clear to all parties that studies will not intentionally expose subjects to hazardous environmental agents. JF - American journal of public health AU - Resnik, David B AU - Wing, Steven AD - National Institute of Environmental Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. resnikd@niehs.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 414 EP - 418 VL - 97 IS - 3 KW - Hazardous Substances KW - 0 KW - Pesticides KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - United States Environmental Protection Agency KW - Motivation KW - Community Participation -- economics KW - Attitude to Health KW - Poverty KW - Humans KW - Conflict of Interest KW - Child KW - Florida KW - Ethics Committees, Research KW - Research Subjects -- economics KW - Child Welfare -- ethics KW - Environmental Exposure -- analysis KW - Household Products -- toxicity KW - Environmental Exposure -- adverse effects KW - Public Health Administration -- methods KW - Ethics, Research KW - Child Welfare -- ethnology KW - Public Health Administration -- ethics KW - Pesticides -- toxicity KW - Hazardous Substances -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69033863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Lessons+learned+from+the+Children%27s+Environmental+Exposure+Research+Study.&rft.au=Resnik%2C+David+B%3BWing%2C+Steven&rft.aulast=Resnik&rft.aufirst=David&rft.date=2007-03-01&rft.volume=97&rft.issue=3&rft.spage=414&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=1541-0048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-12 N1 - Date created - 2007-02-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: JAMA. 2002 Jan 2;287(1):78-84 [11754712] Am J Bioeth. 2001 Spring;1(2):40-4 [11951886] J Toxicol Environ Health. 1997 Apr 25;50(6):581-94 [15279031] J Clin Invest. 2005 Jul;115(7):1681-7 [16007244] Am J Public Health. 2005 Jul;95(7):1123-7 [15983268] Environ Health Perspect. 2005 Jul;113(7):813-7 [16002367] Environ Health Perspect. 2005 Apr;113(4):504-8 [15811843] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Systemic and central amygdala injections of the mGluR(2/3) agonist LY379268 attenuate the expression of incubation of cocaine craving. AN - 69014693; 16893525 AB - We and others reported time-dependent increases in cue-induced cocaine seeking after withdrawal, suggesting that craving incubates over time. Recently, we found that central amygdala extracellular signal-regulated kinases (ERK) and glutamate are involved in this incubation. Here, we further explored the role of central amygdala glutamate in the incubation of cocaine craving by determining the effect of systemic or central amygdala injections of the mGluR2/3 agonist LY379268 (which decreases glutamate release) on cue-induced cocaine seeking during early and late withdrawal. Rats were trained to self-administer cocaine for 10 days (6 hours/day); infusions were paired with a tone-light cue. Cocaine seeking and craving after systemic or central amygdala injections of LY379268 were then assessed in extinction tests in the presence of the cocaine-associated cues during early (day 3) or late (day 21) withdrawal. Systemic (1.5 or 3 mg/kg) or central amygdala (.5 or 1.0 microg/side) injections of LY379268 attenuated enhanced extinction responding on day 21 but had no effect on lower extinction responding on day 3. Results confirm our previous findings on the role of central amygdala glutamate in the incubation of cocaine craving and together with previous reports suggest that mGluR(2/3) agonists should be considered in the treatment of drug relapse. JF - Biological psychiatry AU - Lu, Lin AU - Uejima, Jamie L AU - Gray, Sarah M AU - Bossert, Jennifer M AU - Shaham, Yavin AD - Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA. linlu@bjmu.edu.cn Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 SP - 591 EP - 598 VL - 61 IS - 5 SN - 0006-3223, 0006-3223 KW - Amino Acids KW - 0 KW - Bridged Bicyclo Compounds, Heterocyclic KW - Dopamine Uptake Inhibitors KW - LY 379268 KW - Receptors, Metabotropic Glutamate KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Conditioning, Operant -- drug effects KW - Animals KW - Analysis of Variance KW - Drug Interactions KW - Rats, Long-Evans KW - Dose-Response Relationship, Drug KW - Cocaine -- administration & dosage KW - Behavior, Animal KW - Drug Administration Routes KW - Rats KW - Self Administration KW - Dopamine Uptake Inhibitors -- administration & dosage KW - Extinction, Psychological -- drug effects KW - Male KW - Amino Acids -- administration & dosage KW - Bridged Bicyclo Compounds, Heterocyclic -- administration & dosage KW - Receptors, Metabotropic Glutamate -- administration & dosage KW - Cocaine-Related Disorders -- psychology KW - Cocaine-Related Disorders -- drug therapy KW - Amygdala -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69014693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Systemic+and+central+amygdala+injections+of+the+mGluR%282%2F3%29+agonist+LY379268+attenuate+the+expression+of+incubation+of+cocaine+craving.&rft.au=Lu%2C+Lin%3BUejima%2C+Jamie+L%3BGray%2C+Sarah+M%3BBossert%2C+Jennifer+M%3BShaham%2C+Yavin&rft.aulast=Lu&rft.aufirst=Lin&rft.date=2007-03-01&rft.volume=61&rft.issue=5&rft.spage=591&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-17 N1 - Date created - 2007-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chitosan solution enhances both humoral and cell-mediated immune responses to subcutaneous vaccination. AN - 69013735; 17258843 AB - The development of safe, novel adjuvants is necessary to maximize the efficacy of new and/or available vaccines. Chitosan is a non-toxic, biocompatible, biodegradable, natural polysaccharide derived from the exoskeletons of crustaceans and insects. Chitosan's biodegradability, immunological activity and high viscosity make it an excellent candidate as a depot/adjuvant for parenteral vaccination. To this end, we explored chitosan solution as an adjuvant for subcutaneous vaccination of mice with a model protein antigen. We found that chitosan enhanced antigen-specific antibody titers over five-fold and antigen-specific splenic CD4+ proliferation over six-fold. Strong increases in antibody titers together with robust delayed-type hypersensitivity (DTH) responses revealed that chitosan induced both humoral and cell-mediated immune responses. When compared with traditional vaccine adjuvants, chitosan was equipotent to incomplete Freund's adjuvant (IFA) and superior to aluminum hydroxide. Mechanistic studies revealed that chitosan exhibited at least two characteristics that may allow it to function as an immune adjuvant. First, the viscous chitosan solution created an antigen depot. More specifically, less than 9% of a protein antigen, when delivered in saline, remained at the injection site after 8 h. However, more than 60% of a protein antigen delivered in chitosan remained at the injection site for 7 days. Second, chitosan induced a transient 67% cellular expansion in draining lymph nodes. The expansion peaked between 14 and 21 days after chitosan injection and diminished as the polysaccharide was degraded. These mechanistic studies, taken together with the enhancement of a vaccine response, demonstrate that chitosan is a promising and safe platform for parenteral vaccine delivery. JF - Vaccine AU - Zaharoff, David A AU - Rogers, Connie J AU - Hance, Kenneth W AU - Schlom, Jeffrey AU - Greiner, John W AD - Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, United States. Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 SP - 2085 EP - 2094 VL - 25 IS - 11 SN - 0264-410X, 0264-410X KW - Adjuvants, Immunologic KW - 0 KW - Antibodies KW - Lipids KW - Vaccines KW - incomplete Freund's adjuvant KW - Aluminum Hydroxide KW - 5QB0T2IUN0 KW - Freund's Adjuvant KW - 9007-81-2 KW - Chitosan KW - 9012-76-4 KW - beta-Galactosidase KW - EC 3.2.1.23 KW - Index Medicus KW - Models, Animal KW - Animals KW - Skin -- pathology KW - CD4-Positive T-Lymphocytes -- immunology KW - Mice KW - Histocytochemistry KW - beta-Galactosidase -- immunology KW - Lymph Nodes -- cytology KW - Lymphocyte Activation KW - Aluminum Hydroxide -- immunology KW - Hypersensitivity, Delayed KW - Mice, Inbred C57BL KW - Injections, Subcutaneous KW - Enzyme-Linked Immunosorbent Assay KW - Female KW - Vaccines -- immunology KW - Antibodies -- blood KW - Chitosan -- pharmacokinetics KW - Chitosan -- immunology KW - Vaccines -- administration & dosage KW - Vaccination UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69013735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aabiglobal&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Strategic+Direction&rft.atitle=Scenarios+and+long-term+technology+strategy&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=1996-10-01&rft.volume=&rft.issue=127&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=Strategic+Direction&rft.issn=02580543&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-23 N1 - Date created - 2007-02-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharm Pharmacol. 2001 Aug;53(8):1047-67 [11518015] Brain. 2001 Sep;124(Pt 9):1821-31 [11522584] Adv Drug Deliv Rev. 2001 Nov 5;52(2):139-44 [11718937] Adv Drug Deliv Rev. 2001 Dec 3;53(1):45-73 [11733117] Infect Immun. 2003 Feb;71(2):726-32 [12540551] Int Immunopharmacol. 2003 Aug;3(8):1187-93 [12860174] J Autoimmun. 2003 Aug;21(1):1-9 [12892730] Vaccine. 2003 Dec 8;22(1):64-9 [14604572] Mol Cancer Ther. 2003 Nov;2(11):1233-42 [14617797] Am J Clin Nutr. 2004 Apr;79(4):529-36 [15051593] Vaccine. 2004 May 7;22(15-16):1845 [15121293] Vaccine. 2004 Feb 25;22(8):909-14 [15161067] Lancet Infect Dis. 2004 Jun;4(6):324; discussion 325 [15172337] Biomed Pharmacother. 2004 Jun;58(5):325-37 [15194169] Immunol Cell Biol. 2004 Oct;82(5):488-96 [15479434] Bull World Health Organ. 1965;32(5):603-25 [5294176] J Pharm Sci. 1970 Aug;59(8):1084-8 [4989723] Br J Obstet Gynaecol. 1980 Apr;87(4):292-5 [6158992] Vaccine. 1984 Mar;2(1):93-9 [6397928] Vaccine. 1985 Dec;3(5):379-84 [3936299] Vaccine. 1986 Sep;4(3):151-6 [2429471] Biomaterials. 1988 May;9(3):247-52 [3408796] Biomaterials. 1989 Oct;10(8):574-6 [2605289] Int J Biol Macromol. 1990 Oct;12(5):295-6 [2085495] Arch Immunol Ther Exp (Warsz). 1991;39(1-2):127-32 [1804042] J Autoimmun. 1991 Dec;4(6):871-80 [1812893] J Autoimmun. 1993 Aug;6(4):449-58 [7692869] Biomaterials. 1994 Dec;15(15):1215-20 [7703317] Pharm Biotechnol. 1995;6:141-228 [7551218] Vaccine. 1995 Oct;13(14):1263-76 [8585280] Pharm Res. 1998 Sep;15(9):1326-31 [9755881] Biomaterials. 1999 Jan;20(2):175-82 [10022787] Mol Immunol. 2005 Feb;42(4):535-9 [15607810] Obes Rev. 2005 Feb;6(1):35-42 [15655037] Vaccine. 2005 Feb 3;23(11):1359-67 [15661384] Vaccine. 2005 Aug 15;23(35):4367-74 [15916838] Blood. 2006 Feb 15;107(4):1342-51 [16223768] J Trauma. 2006 Mar;60(3):655-8 [16531872] Vaccine. 2000 Nov 8;19(6):661-8 [11090719] Cancer Res. 2001 Jan 1;61(1):206-14 [11196163] Adv Drug Deliv Rev. 2001 Sep 23;51(1-3):81-96 [11516781] Lancet Infect Dis. 2006 Apr;6(4):189 [16554241] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gelsolin: a novel thyroid hormone receptor-beta interacting protein that modulates tumor progression in a mouse model of follicular thyroid cancer. AN - 69013367; 17170101 AB - Follicular thyroid cancer (FTC) is known to metastasize to distant sites via hematogenous spread; however, the underlying pathways that contribute to metastasis remain unknown. Recent creation of a knockin mutant mouse that expresses a mutant thyroid hormone receptor-beta (TRbeta(PV/PV) mouse) that spontaneously develops thyroid cancer with metastasis similar to humans has provided new opportunities to study contributors to FTC metastasis. This study evaluates the role of gelsolin, an actin-regulatory protein, in modulating the metastatic potential of FTC. Gelsolin was previously found by cDNA microarray analysis to be down-regulated in TRbeta(PV/PV) mice as compared with wild-type mice. This study found an age-dependent reduction of gelsolin protein abundance in TRbeta(PV/PV) mice as tumorigenesis progressed. Knockdown of gelsolin by small interfering RNA resulted in increased tumor cell motility and increased gelsolin expression by histone deacetylase inhibitor (trichostatin A) led to decreased cell motility. Additional biochemical analyses demonstrated that gelsolin physically interacted with TRbeta1 or PV in vivo and in vitro. The interaction regions were mapped to the C terminus of gelsolin and the DNA binding domain of TR. The physical interaction of gelsolin with PV reduced its binding to actin, leading to disarrayed cytoskeletal architectures. These results suggest that PV-induced alteration of the actin/gelsolin cytoskeleton contributes to increased cell motility. Thus, the present study uncovered a novel PV-mediated oncogenic pathway that could contribute to the local tumor progression and metastatic potential of thyroid carcinogenesis. JF - Endocrinology AU - Kim, Caroline S AU - Furuya, Fumihiko AU - Ying, Hao AU - Kato, Yasuhito AU - Hanover, John A AU - Cheng, Sheue-yann AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Bethesda, MD 20892-4264, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 1306 EP - 1312 VL - 148 IS - 3 SN - 0013-7227, 0013-7227 KW - Actins KW - 0 KW - Gelsolin KW - Mutant Proteins KW - Thyroid Hormone Receptors beta KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Cells, Cultured KW - Mutant Proteins -- metabolism KW - Cercopithecus aethiops KW - Disease Progression KW - Disease Models, Animal KW - Actins -- metabolism KW - Mice KW - Cell Movement -- genetics KW - Mice, Transgenic KW - Protein Binding KW - Thyroid Gland -- metabolism KW - Thyroid Hormone Receptors beta -- metabolism KW - Gelsolin -- metabolism KW - Gelsolin -- physiology KW - Thyroid Neoplasms -- pathology KW - Thyroid Hormone Receptors beta -- genetics KW - Carcinoma, Papillary, Follicular -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69013367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+American+Society+for+Microbiology+Biodefense+and+Emerging+Diseases+Research&rft.atitle=Blood+Pressure+Increases+with+Norepinephrine+Infusion+Improved+Survival+with+Lipopolysaccharide+%28LPS%29+but+not+Anthrax+Lethal+Toxin+%28LeTx%29+Challenge+in+Rats&rft.au=Li%2C+Y.%3BCui%2C+X%3BSu%2C+J.%3BSherer%2C+K%3BLeppla%2C+S%3BMoayeri%2C+M%3BKenyon%2C+N%3BScher%2C+D%3BFitz%2C+Y%3BEichacker%2C+P+Q&rft.aulast=Li&rft.aufirst=Y.&rft.date=2007-02-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+American+Society+for+Microbiology+Biodefense+and+Emerging+Diseases+Research&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-04 N1 - Date created - 2007-02-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - 2-methoxyestradiol induces mammary gland differentiation through amphiregulin-epithelial growth factor receptor-mediated signaling: molecular distinctions from the mammary gland of pregnant mice. AN - 69011663; 17158205 AB - Levels of 2-methoxyestradiol (2ME(2)), an endogenous metabolite of estradiol, are highly elevated during late stages of pregnancy when mammary glands have differentiated with the formation of alveolar structures producing milk proteins. Based upon our previous demonstration that 2ME(2) induces mammary ductal dilation associated with expression of mammary differentiation markers when administered to transgenic mice that spontaneously develop mammary cancer, we studied the effects of 2ME(2) on normal mammary gland development. The results of this study demonstrate that 2ME(2) can induce a partial differentiation of normal mammary glands in virgin mice, as evidenced by the appearance of limited numbers of alveolar cells and significantly increased expression of the differentiation markers beta-casein and whey acidic protein. 2ME(2)-induced differentiation is associated with inhibition of expression of inhibitor of differentiation 1 (Id-1) in normal mammary epithelial cells through elements in the 5'-flanking region of the Id-1 gene. Microarray analysis revealed that 2ME(2)-induced differentiation of the mammary gland shares some significant similarities in gene expression with that of mammary glands from late-stage pregnancy, including elevated expression of many milk protein differentiation markers. However, several genes are differentially regulated between 2ME(2)-treated mammary glands and differentiated mammary glands through pregnancy. Significantly, amphiregulin, ATF3, serpine2, and SOX6 were up-regulated in 2ME(2)-treated mammary glands but not in mammary glands from pregnant mice. Using the SCp2 differentiation cell line system, we demonstrate that 2ME(2) induces differentiation through the down-regulation of Id-1 and up-regulation of amphiregulin. Administration of amphiregulin to SCp2 cells induced differentiation, whereas inhibition of 2ME(2)-induced expression of amphiregulin by small interfering RNA blocked differentiation. Estrogen receptor-negative SCp2 cells differentiate in response to 2ME(2), but not estradiol, suggesting that 2ME(2) operates through an estrogen receptor-independent mechanism. These data demonstrate that 2ME(2) can induce a partial differentiation of the mammary gland through mechanisms that differ from those normally used during pregnancy. JF - Endocrinology AU - Huh, Jung-Im AU - Qiu, Ting Hu AU - Chandramouli, Gadisetti V R AU - Charles, Rhonda AU - Wiench, Malgorzata AU - Hager, Gordon L AU - Catena, Raul AU - Calvo, Alfonso AU - LaVallee, Theresa M AU - Desprez, Pierre-Yves AU - Green, Jeffrey E AD - Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Building 41, 41 Medlars Drive, Bethesda, MD 20892, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 1266 EP - 1277 VL - 148 IS - 3 SN - 0013-7227, 0013-7227 KW - Amphiregulin KW - 0 KW - Areg protein, mouse KW - EGF Family of Proteins KW - Glycoproteins KW - Idb1 protein, mouse KW - Inhibitor of Differentiation Protein 1 KW - Intercellular Signaling Peptides and Proteins KW - Milk Proteins KW - Estradiol KW - 4TI98Z838E KW - 2-methoxyestradiol KW - 6I2QW73SR5 KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Abridged Index Medicus KW - Index Medicus KW - Mice, Inbred Strains KW - Gene Expression Profiling KW - Animals KW - Cells, Cultured KW - Milk Proteins -- metabolism KW - Inhibitor of Differentiation Protein 1 -- metabolism KW - Mice KW - Signal Transduction KW - Female KW - Pregnancy KW - Estradiol -- analogs & derivatives KW - Mammary Glands, Animal -- drug effects KW - Mammary Glands, Animal -- cytology KW - Estradiol -- pharmacology KW - Receptor, Epidermal Growth Factor -- physiology KW - Cell Differentiation -- drug effects KW - Intercellular Signaling Peptides and Proteins -- physiology KW - Glycoproteins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69011663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=2-methoxyestradiol+induces+mammary+gland+differentiation+through+amphiregulin-epithelial+growth+factor+receptor-mediated+signaling%3A+molecular+distinctions+from+the+mammary+gland+of+pregnant+mice.&rft.au=Huh%2C+Jung-Im%3BQiu%2C+Ting+Hu%3BChandramouli%2C+Gadisetti+V+R%3BCharles%2C+Rhonda%3BWiench%2C+Malgorzata%3BHager%2C+Gordon+L%3BCatena%2C+Raul%3BCalvo%2C+Alfonso%3BLaVallee%2C+Theresa+M%3BDesprez%2C+Pierre-Yves%3BGreen%2C+Jeffrey+E&rft.aulast=Huh&rft.aufirst=Jung-Im&rft.date=2007-03-01&rft.volume=148&rft.issue=3&rft.spage=1266&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-04 N1 - Date created - 2007-02-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pharmacological and genetic manipulation of kappa opioid receptors: effects on cocaine- and pentylenetetrazol-induced convulsions and seizure kindling. AN - 69011383; 17126860 AB - The present study used pharmacological and gene ablation techniques to examine the involvement of kappa opioid receptors (KOPr) in modulating the convulsant effects of two mechanistically different drugs: cocaine and pentylenetetrazol (PTZ; GABA-A receptor antagonist) in mice. Systemic administration of the selective KOPr-1 agonist, U69593 (0.16-0.6mg/kg; s.c.), failed to modify cocaine-evoked convulsions or cocaine kindling. Similarly, no alteration in responsiveness to cocaine was observed in wild-type mice that received the selective KOPr-1 antagonist, nor-binaltorphimine (nor-BNI; 5mg/kg) or in mice lacking the gene encoding KOPr-1. In contrast to cocaine, U69593 attenuated the seizures induced by acute or repeated PTZ administration. Nor-BNI decreased the threshold for PTZ-evoked seizures and increased seizure incidence during the initial induction of kindling relative to controls. Decreased thresholds for PTZ-induced seizures were also observed in KOPr-1 knock out mice. Together, these data demonstrate an involvement of endogenous KOPr systems in modulating vulnerability to the convulsant effects of PTZ but not cocaine. Furthermore, they demonstrate that KOPr-1 activation protects against acute and kindled seizures induced by this convulsant. Finally, the results of our study suggest that KOPr-1 antagonists will not have therapeutic utility against cocaine-induced seizures, while they may prove beneficial in attenuating several actions of cocaine that have been linked to its abuse. JF - Neuropharmacology AU - Kaminski, Rafal M AU - Witkin, Jeffrey M AU - Shippenberg, Toni S AD - Integrative Neuroscience Section, Behavioral Neuroscience Branch, NIH/NIDA Intramural Research Program, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. kaminskr@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 895 EP - 903 VL - 52 IS - 3 SN - 0028-3908, 0028-3908 KW - Analgesics KW - 0 KW - Benzeneacetamides KW - Narcotic Antagonists KW - Pyrrolidines KW - Receptors, Opioid, kappa KW - kappa(1) opioid receptor KW - norbinaltorphimine KW - 36OOQ86QM1 KW - Naltrexone KW - 5S6W795CQM KW - Cocaine KW - I5Y540LHVR KW - U 69593 KW - J5S4K6TKTG KW - Pentylenetetrazole KW - WM5Z385K7T KW - Index Medicus KW - Animals KW - Naltrexone -- administration & dosage KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Naltrexone -- analogs & derivatives KW - Mice KW - Mice, Knockout KW - Narcotic Antagonists -- administration & dosage KW - Behavior, Animal -- drug effects KW - Pyrrolidines -- therapeutic use KW - Benzeneacetamides -- therapeutic use KW - Mice, Inbred C57BL KW - Analgesics -- therapeutic use KW - Male KW - Seizures -- chemically induced KW - Receptors, Opioid, kappa -- genetics KW - Seizures -- genetics KW - Seizures -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69011383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Pharmacological+and+genetic+manipulation+of+kappa+opioid+receptors%3A+effects+on+cocaine-+and+pentylenetetrazol-induced+convulsions+and+seizure+kindling.&rft.au=Kaminski%2C+Rafal+M%3BWitkin%2C+Jeffrey+M%3BShippenberg%2C+Toni+S&rft.aulast=Kaminski&rft.aufirst=Rafal&rft.date=2007-03-01&rft.volume=52&rft.issue=3&rft.spage=895&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-01 N1 - Date created - 2007-02-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Previous exposure to THC alters the reinforcing efficacy and anxiety-related effects of cocaine in rats. AN - 69010656; 16738542 AB - The hypothesis that prior cannabis exposure increases the likelihood of becoming addicted to other drugs can be evaluated by giving rats a history of tetrahydrocannabinol (THC) exposure, then allowing them to self-administer other drugs. In Experiment 1, THC pre-exposure did not alter the acquisition of cocaine self-administration or the amount of cocaine taken under a fixed-ratio 1 (FR1) schedule, with one response required for each injection. Under a progressive-ratio schedule, with the response requirement increasing exponentially with each injection, cocaine-seeking was significantly reduced in THC-exposed rats, suggesting that the regimen of THC exposure used in the present study caused cocaine to be devalued as a reinforcer. In contrast, in an earlier study that used the same regimen, a history of THC exposure did not alter the value of heroin as a reinforcer under the progressive-ratio schedule, but it increased heroin self-administration under the FR1 schedule. Experiment 2 examined how this regimen of THC pre-exposure alters the locomotor effects of cocaine and heroin. THC pre-exposure produced cross-tolerance to the motor-depressant effects of heroin; this may explain the shortened post-injection pauses exhibited by THC-exposed rats under FR1 heroin self-administration. When given cocaine, THC-exposed rats exhibited normal increases in locomotion, but they avoided the center of the open field, suggesting that this THC pre-exposure regimen enhances the anxiogenic effects of cocaine. This enhanced anxiogenic effect-which was verified in Experiment 3 using another model of anxiety, the light-dark test-may explain the reduced reinforcing value of cocaine observed in THC-exposed rats in Experiment 1. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Panlilio, Leigh V AU - Solinas, Marcello AU - Matthews, Stephanie A AU - Goldberg, Steven R AD - Department of Health and Human Services, Preclinical Pharmacology Section, Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 646 EP - 657 VL - 32 IS - 3 SN - 0893-133X, 0893-133X KW - Analgesics, Non-Narcotic KW - 0 KW - Dopamine Uptake Inhibitors KW - Dronabinol KW - 7J8897W37S KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Rats KW - Conditioning, Operant -- drug effects KW - Reaction Time -- drug effects KW - Animals KW - Rats, Sprague-Dawley KW - Drug Interactions KW - Self Administration KW - Reinforcement Schedule KW - Choice Behavior -- drug effects KW - Motor Activity -- drug effects KW - Behavior, Animal KW - Analgesics, Non-Narcotic -- pharmacology KW - Anxiety -- chemically induced KW - Dronabinol -- pharmacology KW - Dopamine Uptake Inhibitors -- administration & dosage KW - Reinforcement (Psychology) KW - Anxiety -- physiopathology KW - Cocaine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69010656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Previous+exposure+to+THC+alters+the+reinforcing+efficacy+and+anxiety-related+effects+of+cocaine+in+rats.&rft.au=Panlilio%2C+Leigh+V%3BSolinas%2C+Marcello%3BMatthews%2C+Stephanie+A%3BGoldberg%2C+Steven+R&rft.aulast=Panlilio&rft.aufirst=Leigh&rft.date=2007-03-01&rft.volume=32&rft.issue=3&rft.spage=646&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-05 N1 - Date created - 2007-02-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bayesian methods for highly correlated exposure data. AN - 69008796; 17272963 AB - Studies that include individuals with multiple highly correlated exposures are common in epidemiology. Because standard maximum likelihood techniques often fail to converge in such instances, hierarchical regression methods have seen increasing use. Bayesian hierarchical regression places prior distributions on exposure-specific regression coefficients to stabilize estimation and incorporate prior knowledge, if available. A common parametric approach in epidemiology is to treat the prior mean and variance as fixed constants. An alternative parametric approach is to place distributions on the prior mean and variance to allow the data to help inform their values. As a more flexible semiparametric option, one can place an unknown distribution on the coefficients that simultaneously clusters exposures into groups using a Dirichlet process prior. We also present a semiparametric model with a variable-selection prior to allow clustering of coefficients at 0. We compare these 4 hierarchical regression methods and demonstrate their application in an example estimating the association of herbicides with retinal degeneration among wives of pesticide applicators. JF - Epidemiology (Cambridge, Mass.) AU - MacLehose, Richard F AU - Dunson, David B AU - Herring, Amy H AU - Hoppin, Jane A AD - Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. maclehoser@niehs.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 199 EP - 207 VL - 18 IS - 2 SN - 1044-3983, 1044-3983 KW - Herbicides KW - 0 KW - Index Medicus KW - Herbicides -- adverse effects KW - Retinal Degeneration -- epidemiology KW - Humans KW - Nonlinear Dynamics KW - Bias (Epidemiology) KW - Retinal Degeneration -- etiology KW - Statistics, Nonparametric KW - Confounding Factors (Epidemiology) KW - Environmental Exposure KW - Bayes Theorem KW - Models, Statistical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69008796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+%28Cambridge%2C+Mass.%29&rft.atitle=Bayesian+methods+for+highly+correlated+exposure+data.&rft.au=MacLehose%2C+Richard+F%3BDunson%2C+David+B%3BHerring%2C+Amy+H%3BHoppin%2C+Jane+A&rft.aulast=MacLehose&rft.aufirst=Richard&rft.date=2007-03-01&rft.volume=18&rft.issue=2&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Epidemiology+%28Cambridge%2C+Mass.%29&rft.issn=10443983&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-22 N1 - Date created - 2007-02-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Epidemiology. 2007 Mar;18(2):186-90 [17301703] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Diurnal temperature range and daily mortality in Shanghai, China. AN - 69007877; 17234178 AB - Although the relationship between temperature level and mortality outcomes has been well established, it is still unknown whether within-day variation in temperature, e.g. diurnal temperature range (DTR), is a risk factor for death independent of the corresponding temperature. Moreover, DTR is a meteorological indicator associated with global climate change which may be related to a variety of health outcomes. We hypothesized that large diurnal temperature change might be a source of additional environmental stress and therefore a risk factor for death. We used daily weather and mortality data from Shanghai, China to test this hypothesis. We conducted a time-series study to examine the association between DTR and mortality outcomes from 2001 to 2004. A semi-parametric generalized additive model (GAM) was used to assess the acute effect of DTR on mortality after controlling for covariates including time trend, day of the week (DOW), temperature, humidity, and outdoor air pollution. We found a strong association between DTR and daily mortality after adjustment for those potential confounders. A 1 degrees C increment of the 3-day moving average of DTR corresponded to a 1.37% (95% CI 1.08-1.65%) increase in total non-accidental mortality, a 1.86% (95% CI 1.40-2.32%) increase in cardiovascular mortality, and a 1.29% (95% CI 0.49-2.09%) increase in respiratory mortality. The effects of DTR on total non-accidental and cardiovascular mortality were significant on both "cold" (below 23 degrees C) and "warm" (at least 23 degrees C) days, although respiratory mortality was only significantly associated with DTR on "cold" days. This study suggests within-day variation in temperature may be a novel risk factor for death. JF - Environmental research AU - Kan, Haidong AU - London, Stephanie J AU - Chen, Honglei AU - Song, Guixiang AU - Chen, Guohai AU - Jiang, Lili AU - Zhao, Naiqing AU - Zhang, Yunhui AU - Chen, Bingheng AD - Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China. kanh@niehs.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 424 EP - 431 VL - 103 IS - 3 SN - 0013-9351, 0013-9351 KW - Index Medicus KW - Regression Analysis KW - Air Pollution -- analysis KW - Risk Factors KW - Humans KW - China -- epidemiology KW - Databases, Factual KW - Humidity KW - Mortality KW - Cities KW - Temperature UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69007877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+research&rft.atitle=Diurnal+temperature+range+and+daily+mortality+in+Shanghai%2C+China.&rft.au=Kan%2C+Haidong%3BLondon%2C+Stephanie+J%3BChen%2C+Honglei%3BSong%2C+Guixiang%3BChen%2C+Guohai%3BJiang%2C+Lili%3BZhao%2C+Naiqing%3BZhang%2C+Yunhui%3BChen%2C+Bingheng&rft.aulast=Kan&rft.aufirst=Haidong&rft.date=2007-03-01&rft.volume=103&rft.issue=3&rft.spage=424&rft.isbn=&rft.btitle=&rft.title=Environmental+research&rft.issn=00139351&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-27 N1 - Date created - 2007-02-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Incident pain and analgesic consumption decrease after samarium infusion: a pilot study. AN - 69004024; 16967302 AB - The aim of this pilot study was to observe the variations of pain intensity on movement and at rest and the variation of analgesic drug consumption in patients with prostate cancer and painful bone metastases treated with a single dose of 1.0 mCi/kg of samarium-153 (153-Sm) lexidronam. Case series. The Nuclear Medicine Unit and Pain Therapy and Palliative Care Unit, National Cancer Institute of Milan, Italy. Thirteen outpatients with hormone refractory prostate cancer and painful multiple bone metastases. Infusion of a single dose of 1.0 mCi/kg of 153-Sm lexidronam, pain therapy, and the assessment of pain intensity at rest and on movement. Variation of pain intensity on movement and at rest by means of a verbal scale and the reduction of analgesic drug consumption 4 weeks after infusion of 153-Sm lexidronam. From baseline, 61.5% of patients reported a decrease of at least two levels of pain intensity on movement and 53.8% of patients had an improvement of pain at rest. Of the patients, 15.4% were not in pain at rest or on movement at baseline and continued to be free of pain 4 weeks after the administration of samarium. All ten patients, but one, who were on analgesic drugs before samarium infusion, reduced the regular drug administration or rescue medication. Bone marrow toxicity was mild and readily reversible in three patients. In patients with bone metastases, pain on movement is a frequent and often difficult clinical problem to treat and the most frequent cause of breakthrough pain. In patients with painful multiple bone metastases due to prostate cancer, the infusion of a single dose of 1.0 mCi/kg of 153-Sm lexidronam may be considered an effective and safe treatment for pain either at rest or during movement. JF - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer AU - Ripamonti, Carla AU - Fagnoni, Elena AU - Campa, Tiziana AU - Seregni, Ettore AU - Maccauro, Marco AU - Bombardieri, Emilio AD - Rehabilitation and Palliative Care Operative Unit, National Cancer Institute of Milan, Via Venezian, 1, Milan, Italy. carla.ripamonti@istitutotumori.mi.it Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 339 EP - 342 VL - 15 IS - 3 SN - 0941-4355, 0941-4355 KW - Analgesics, Non-Narcotic KW - 0 KW - Analgesics, Opioid KW - Anti-Inflammatory Agents, Non-Steroidal KW - Organometallic Compounds KW - Organophosphorus Compounds KW - samarium Sm-153 lexidronam KW - 745X144DZY KW - Morphine KW - 76I7G6D29C KW - Index Medicus KW - Severity of Illness Index KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Infusions, Intravenous KW - Dose-Response Relationship, Drug KW - Humans KW - Pain Measurement KW - Aged KW - Pilot Projects KW - Movement KW - Prostatic Neoplasms -- pathology KW - Morphine -- therapeutic use KW - Prospective Studies KW - Treatment Outcome KW - Rest KW - Analgesics, Opioid -- therapeutic use KW - Middle Aged KW - Bone Marrow -- drug effects KW - Bone Neoplasms -- secondary KW - Male KW - Pain -- etiology KW - Organophosphorus Compounds -- therapeutic use KW - Analgesics, Non-Narcotic -- adverse effects KW - Pain -- drug therapy KW - Pain -- physiopathology KW - Analgesics, Non-Narcotic -- therapeutic use KW - Organophosphorus Compounds -- adverse effects KW - Organometallic Compounds -- adverse effects KW - Organometallic Compounds -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69004024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Supportive+care+in+cancer+%3A+official+journal+of+the+Multinational+Association+of+Supportive+Care+in+Cancer&rft.atitle=Incident+pain+and+analgesic+consumption+decrease+after+samarium+infusion%3A+a+pilot+study.&rft.au=Ripamonti%2C+Carla%3BFagnoni%2C+Elena%3BCampa%2C+Tiziana%3BSeregni%2C+Ettore%3BMaccauro%2C+Marco%3BBombardieri%2C+Emilio&rft.aulast=Ripamonti&rft.aufirst=Carla&rft.date=2007-03-01&rft.volume=15&rft.issue=3&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Supportive+care+in+cancer+%3A+official+journal+of+the+Multinational+Association+of+Supportive+Care+in+Cancer&rft.issn=09414355&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-10 N1 - Date created - 2007-02-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Amino acid substitutions at multiple sites within the vaccinia virus D13 scaffold protein confer resistance to rifampicin. AN - 69001237; 17055024 AB - D13 protein trimers, which form an external lattice providing curvature to the membrane of vaccinia virus immature virions, are the target of the drug rifampicin. We obtained 63 rifampicin-resistant mutants following random PCR mutagenesis of the D13L gene and 5 that arose spontaneously. Sequencing indicated that 26 mutants contained a single, unique, amino acid substitution whereas others contained 2 or more. The single mutations, including 6 previously identified, mapped to 24 different amino acids that were distributed over the length of the protein with the majority clustered between amino acids 17 to 33, 222 to 243 and 480 to 488. Two or three different substitutions occurred in six of the 24 amino acids. Representative mutant viruses of each cluster replicated to wild-type levels in the absence of rifampicin and nearly two logs higher than wild-type in the presence of drug. The large number and fitness of the mutations are remarkable in view of the extreme sequence conservation (99-100% amino acid identity amongst all orthopoxviruses). Clustering of mutations could suggest the presence of a rifampicin-binding pocket comprised of discontinuous regions of D13. JF - Virology AU - Charity, James C AU - Katz, Ehud AU - Moss, Bernard AD - Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 SP - 227 EP - 232 VL - 359 IS - 1 SN - 0042-6822, 0042-6822 KW - Antiviral Agents KW - 0 KW - DNA, Viral KW - Viral Proteins KW - Rifampin KW - VJT6J7R4TR KW - Index Medicus KW - Polymerase Chain Reaction KW - Viral Plaque Assay KW - DNA Mutational Analysis KW - Sequence Analysis, DNA KW - Mutation, Missense KW - DNA, Viral -- genetics KW - Mutagenesis KW - Viral Proteins -- genetics KW - Vaccinia virus -- genetics KW - Vaccinia virus -- growth & development KW - Antiviral Agents -- pharmacology KW - Drug Resistance, Viral -- genetics KW - Vaccinia virus -- drug effects KW - Rifampin -- pharmacology KW - Amino Acid Substitution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69001237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Amino+acid+substitutions+at+multiple+sites+within+the+vaccinia+virus+D13+scaffold+protein+confer+resistance+to+rifampicin.&rft.au=Charity%2C+James+C%3BKatz%2C+Ehud%3BMoss%2C+Bernard&rft.aulast=Charity&rft.aufirst=James&rft.date=2007-03-01&rft.volume=359&rft.issue=1&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-03 N1 - Date created - 2007-02-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 2001 Dec;75(23):11720-34 [11689653] J Cell Biol. 2005 Sep 12;170(6):971-81 [16144903] Biochem Biophys Res Commun. 1969 Aug 22;36(5):858-65 [4980102] Nature. 1969 Dec 27;224(5226):1280-4 [5359293] Virology. 1970 Apr;40(4):1039-51 [4317898] J Virol. 1970 Oct;6(4):519-33 [5497899] Virology. 1986 Apr 15;150(1):45-54 [3952988] Virology. 1987 Jan;156(1):138-45 [3811229] J Mol Biol. 1988 Jul 5;202(1):45-58 [3050121] Virology. 1989 May;170(1):227-37 [2718382] Virology. 1992 Apr;187(2):643-53 [1546459] Virology. 1993 Jun;194(2):638-46 [8503179] J Virol. 1994 Feb;68(2):1103-14 [8289340] Virology. 1995 Dec 20;214(2):494-502 [8553551] J Biophys Biochem Cytol. 1961 Aug;10:475-503 [13719413] J Cell Biol. 2005 Apr 25;169(2):269-83 [15851517] Cancer Res. 1966 May;26(5):995-1008 [4286870] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Molecular mechanisms of sister-chromatid exchange. AN - 68992350; 17157333 AB - Sister-chromatid exchange (SCE) is the process whereby, during DNA replication, two sister chromatids break and rejoin with one another, physically exchanging regions of the parental strands in the duplicated chromosomes. This process is considered to be conservative and error-free, since no information is generally altered during reciprocal interchange by homologous recombination. Upon the advent of non-radiolabel detection methods for SCE, such events were used as genetic indicators for potential genotoxins/mutagens in laboratory toxicology tests, since, as we now know, most forms of DNA damage induce chromatid exchange upon replication fork collapse. Much of our present understanding of the mechanisms of SCE stems from studies involving nonhuman vertebrate cell lines that are defective in processes of DNA repair and/or recombination. In this article, we present a historical perspective of studies spearheaded by Dr. Anthony V. Carrano and colleagues focusing on SCE as a genetic outcome, and the role of the single-strand break DNA repair protein XRCC1 in suppressing SCE. A more general overview of the cellular processes and key protein "effectors" that regulate the manifestation of SCE is also presented. JF - Mutation research AU - Wilson, David M AU - Thompson, Larry H AD - Laboratory of Molecular Gerontology, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. wilsonda@grc.nia.hin.gov Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 SP - 11 EP - 23 VL - 616 IS - 1-2 SN - 0027-5107, 0027-5107 KW - DNA-Binding Proteins KW - 0 KW - X-ray repair cross complementing protein 1 KW - Index Medicus KW - Animals KW - Cricetulus KW - Models, Genetic KW - Humans KW - CHO Cells KW - Chromosomes, Human, Pair 19 -- genetics KW - Cricetinae KW - DNA Repair KW - Sister Chromatid Exchange KW - DNA-Binding Proteins -- genetics KW - DNA Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68992350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Molecular+mechanisms+of+sister-chromatid+exchange.&rft.au=Wilson%2C+David+M%3BThompson%2C+Larry+H&rft.aulast=Wilson&rft.aufirst=David&rft.date=2007-03-01&rft.volume=616&rft.issue=1-2&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-02 N1 - Date created - 2007-02-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Vegetable and synthetic tannins induce hormesis/toxicity in sea urchin early development and in algal growth. AN - 68972921; 16895741 AB - Mimosa tannin and phenol-based synthetic tannin (syntan) were tested for toxicity to sea urchin (Paracentrotus lividus and Sphaerechinus granularis) early development and to marine algal growth (Dunaliella tertiolecta). Sea urchin embryogenesis was affected by vegetable tannin and syntan water extracts (VTWE and STWE) at levels >or=1mg/L. Developmental defects were significantly decreased at VTWE and STWE levels of 0.1 and 0.3mg/L when control cultures displayed suboptimal quality, i.e. <70% "viable" (normal or retarded) larvae. Fertilization success of sea urchin sperm was increased up to 0.3 mg/L STWE or VTWE, then was inhibited by increasing tannin levels (1-30 mg/L). Offspring abnormalities, following sperm exposure to VTWE or STWE, showed the same shift from hormesis to toxicity. Cell growth bioassays in D. tertiolecta exposed to VTWE or STWE (0.1-30 mg/L) showed non-linear concentration-related toxicity. Novel criteria are suggested in defining control quality that should reveal hormetic effects. JF - Environmental pollution (Barking, Essex : 1987) AU - De Nicola, Elena AU - Meriç, Süreyya AU - Gallo, Marialuisa AU - Iaccarino, Mario AU - Della Rocca, Claudio AU - Lofrano, Giusy AU - Russo, Teresa AU - Pagano, Giovanni AD - Italian National Cancer Institute, G. Pascale Foundation, via M. Semmola, I-80131 Naples, Italy. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 46 EP - 54 VL - 146 IS - 1 SN - 0269-7491, 0269-7491 KW - Hormones KW - 0 KW - Tannins KW - Water Pollutants, Chemical KW - Index Medicus KW - Biological Assay -- methods KW - Animals KW - Mimosa KW - Spermatozoa -- drug effects KW - Toxicity Tests KW - Hormones -- metabolism KW - Embryo, Nonmammalian -- drug effects KW - Male KW - Cytogenetics KW - Sea Urchins -- metabolism KW - Sea Urchins -- drug effects KW - Water Pollutants, Chemical -- toxicity KW - Eukaryota -- drug effects KW - Sea Urchins -- embryology KW - Eukaryota -- growth & development KW - Tannins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68972921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+pollution+%28Barking%2C+Essex+%3A+1987%29&rft.atitle=Vegetable+and+synthetic+tannins+induce+hormesis%2Ftoxicity+in+sea+urchin+early+development+and+in+algal+growth.&rft.au=De+Nicola%2C+Elena%3BMeri%C3%A7%2C+S%C3%BCreyya%3BGallo%2C+Marialuisa%3BIaccarino%2C+Mario%3BDella+Rocca%2C+Claudio%3BLofrano%2C+Giusy%3BRusso%2C+Teresa%3BPagano%2C+Giovanni&rft.aulast=De+Nicola&rft.aufirst=Elena&rft.date=2007-03-01&rft.volume=146&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Environmental+pollution+%28Barking%2C+Essex+%3A+1987%29&rft.issn=02697491&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-17 N1 - Date created - 2007-02-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - HIV Preclinical-Clinical Therapeutics Research: central nervous system approaches. AN - 68539075; 18040818 AB - The prevalence of HIV-associated brain disorders is reportedly increasing due, in part, to the prolonged life span of individuals who are surviving well on highly active antiretroviral treatments (HAART). While clinicians report CNS-related deficits that are more subtle in presentation than the frank dementia evident in the pre-HAART era, the milder presentation continues to substantively reduce an individual's quality of life. The development of novel drugs or therapeutic strategies for treating HIV-related CNS disease is important as most investigators agree that the brain is a sanctuary for latent virus, local viral recrudescence, and associated brain inflammatory responses. The prolonged chronic and cumulative effects on the brain of living with HIV-related inflammatory processes, antiretroviral treatments, and their long-term side effects, toxicities, and brain-related aging processes collectively indicate that the burden of CNS and PNS complications will increase profoundly during the upcoming years. Considering the high expense for new drugs entering CNS-related clinical trials and their ultimately low success rate, the NIMH convened a meeting entitled, HIV Preclinical-Clinical Therapeutics Research Meeting, to discuss the current and proposed novel approaches for neuroAIDS drug development and clinical practices. The purposes of the meeting were twofold: to identify the most promising approaches for future neuroAIDS therapeutics development research and to discuss optimal structures and partnerships with industry that may facilitate the successful movement of compounds from the bench to the bedside. Several themes can be derived from the sessions and are highlighted below for preclinical, translational and clinical neuroAIDS therapeutics research. JF - Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology AU - Kopnisky, Kathy L AU - Bao, Jing AD - Center for Mental Health Research on AIDS, NIH/National Institute of Mental Health, 6001 Executive Blvd/Room 6205 MSC 9619, Rockville, MD 20852, USA. kkopnisk@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 1 EP - 4 VL - 2 IS - 1 KW - Index Medicus KW - Animals KW - AIDS Dementia Complex -- therapy KW - AIDS Dementia Complex -- drug therapy KW - Humans KW - AIDS Dementia Complex -- complications KW - AIDS Dementia Complex -- immunology KW - Antiretroviral Therapy, Highly Active KW - Drug Evaluation, Preclinical -- methods KW - Drug Evaluation, Preclinical -- trends KW - HIV Infections -- complications KW - HIV Infections -- therapy KW - HIV Infections -- immunology KW - HIV Infections -- drug therapy KW - Central Nervous System Viral Diseases -- therapy KW - Central Nervous System Viral Diseases -- immunology KW - Central Nervous System Viral Diseases -- drug therapy KW - Central Nervous System Viral Diseases -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68539075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroimmune+pharmacology+%3A+the+official+journal+of+the+Society+on+NeuroImmune+Pharmacology&rft.atitle=HIV+Preclinical-Clinical+Therapeutics+Research%3A+central+nervous+system+approaches.&rft.au=Kopnisky%2C+Kathy+L%3BBao%2C+Jing&rft.aulast=Kopnisky&rft.aufirst=Kathy&rft.date=2007-03-01&rft.volume=2&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroimmune+pharmacology+%3A+the+official+journal+of+the+Society+on+NeuroImmune+Pharmacology&rft.issn=1557-1904&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-25 N1 - Date created - 2007-11-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alcohol use and tobacco abstinence among adolescents in cessation treatment: preliminary findings. AN - 68412345; 16814935 AB - Although adult alcohol use is negatively associated with tobacco cessation, this relationship has not been reported for adolescents. We assessed the relationship between alcohol use and point prevalence abstinence from smoking in a sample of tobacco-dependent adolescents undergoing cessation treatment. Alcohol use both at baseline and) during tobacco cessation treatment was examined as predicting smoking abstinence in 101 adolescents (age=15.1years, S.D.=1.31years; age at first cigarette=11.3years, S.D.=1.93years; age at first drink=12.01years, S.D.=2.87years) attending a total of 642 treatment visits. Mixed regression analysis showed that participants who reported alcohol use during tobacco cessation treatment were significantly less likely to abstain from tobacco smoking (OR=0.42, 95% CI=0.23-0.78, t=-2.78, df=540, p=0.0057). However, pre-enrollment alcohol use was not significantly associated with either short- or long-term tobacco abstinence. If confirmed in a larger group of adolescents, our findings suggest that youths attempting to quit smoking should abstain from alcohol. JF - Addictive behaviors AU - Jaszyna-Gasior, Maria AU - Schroeder, Jennifer R AU - Moolchan, Eric T AD - National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 617 EP - 621 VL - 32 IS - 3 SN - 0306-4603, 0306-4603 KW - Chewing Gum KW - 0 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Regression Analysis KW - Nicotine -- therapeutic use KW - Administration, Cutaneous KW - Tobacco Use Disorder -- drug therapy KW - Humans KW - Tobacco Use Disorder -- psychology KW - Adolescent KW - Male KW - Female KW - Smoking Cessation -- psychology KW - Alcohol Drinking -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68412345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Alcohol+use+and+tobacco+abstinence+among+adolescents+in+cessation+treatment%3A+preliminary+findings.&rft.au=Jaszyna-Gasior%2C+Maria%3BSchroeder%2C+Jennifer+R%3BMoolchan%2C+Eric+T&rft.aulast=Jaszyna-Gasior&rft.aufirst=Maria&rft.date=2007-03-01&rft.volume=32&rft.issue=3&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-29 N1 - Date created - 2007-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A comparison of noninternalizing (herkinorin) and internalizing (DAMGO) mu-opioid agonists on cellular markers related to opioid tolerance and dependence. AN - 68409742; 17152090 AB - Previous studies established that Tyr-D-Ala-Gly-N-Me-Phe-Gly-ol (DAMGO) and (2S,4aR,6aR,7R,9S,10aS,10bR)-9-(Benzoyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho-[2,1-c]pyran-7-carboxylic acid methyl ester (herkinorin) are fully efficacious mu-agonists. Herkinorin (HERK), unlike DAMGO, does not recruit beta-arrestin and promote mu-receptor internalization, even in cells that over express beta-arrestin. We hypothesized that chronic HERK and DAMGO treatment will differentially affect cellular markers of tolerance and dependence. CHO cells expressing the cloned human mu-receptor were treated for 20 h with 10 microM DAMGO, HERK, morphine, or medium. Both DAMGO and HERK acted as full agonists in the [(35)S]GTP-gamma-S binding assay with E(MAX) values of 230% and EC(50) values of 12.8 and 92.5 nM, respectively. In the cAMP assay, DAMGO and HERK had similar E(MAX) values of approximately 80% and EC(50) values of 3.23 and 48.7 nM, respectively. Chronic exposure to both drugs produced moderate tolerance to both drugs ( approximately 2 to 5 fold) in the [(35)S]GTP-gamma-S binding assay. In the cAMP assay, chronic DAMGO produced tolerance to both drugs ( approximately 3 to 4 fold). Chronic HERK eliminated the ability of either drug to inhibit forskolin-stimulated cAMP accumulation. Chronic DAMGO increased, and chronic HERK decreased, forskolin-stimulated cAMP accumulation. Naloxone, after chronic HERK (but not DAMGO) induced a large increase in forskolin-stimulated cAMP accumulation. Viewed collectively with published data, the current data indicate that both internalizing and noninternalizing mu-agonists produce cellular signs of tolerance and dependence. JF - Synapse (New York, N.Y.) AU - Xu, Heng AU - Partilla, John S AU - Wang, Xiaoying AU - Rutherford, John M AU - Tidgewell, Kevin AU - Prisinzano, Thomas E AU - Bohn, Laura M AU - Rothman, Richard B AD - Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, Maryland 21224, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 166 EP - 175 VL - 61 IS - 3 SN - 0887-4476, 0887-4476 KW - 9-(benzoyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho(2,1-c)pyran-7-carboxylic acid methyl ester KW - 0 KW - Analgesics, Opioid KW - Furans KW - Narcotic Antagonists KW - Pyrones KW - Receptors, Opioid, mu KW - Enkephalin, Ala(2)-MePhe(4)-Gly(5)- KW - 100929-53-1 KW - Colforsin KW - 1F7A44V6OU KW - Guanosine 5'-O-(3-Thiotriphosphate) KW - 37589-80-3 KW - Cyclic AMP KW - E0399OZS9N KW - Index Medicus KW - Animals KW - Cricetulus KW - Humans KW - Binding, Competitive -- physiology KW - Binding, Competitive -- drug effects KW - Radioligand Assay KW - Colforsin -- pharmacology KW - Analgesics, Opioid -- pharmacology KW - Cyclic AMP -- metabolism KW - Endocytosis -- drug effects KW - Guanosine 5'-O-(3-Thiotriphosphate) -- metabolism KW - CHO Cells KW - Cyclic AMP -- analysis KW - Narcotic Antagonists -- pharmacology KW - Endocytosis -- physiology KW - Cricetinae KW - Pyrones -- pharmacology KW - Opioid-Related Disorders -- physiopathology KW - Opioid-Related Disorders -- metabolism KW - Furans -- pharmacology KW - Enkephalin, Ala(2)-MePhe(4)-Gly(5)- -- pharmacology KW - Receptors, Opioid, mu -- agonists KW - Drug Tolerance -- physiology KW - Cell Membrane -- drug effects KW - Receptors, Opioid, mu -- metabolism KW - Cell Membrane -- metabolism KW - Receptors, Opioid, mu -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68409742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Synapse+%28New+York%2C+N.Y.%29&rft.atitle=A+comparison+of+noninternalizing+%28herkinorin%29+and+internalizing+%28DAMGO%29+mu-opioid+agonists+on+cellular+markers+related+to+opioid+tolerance+and+dependence.&rft.au=Xu%2C+Heng%3BPartilla%2C+John+S%3BWang%2C+Xiaoying%3BRutherford%2C+John+M%3BTidgewell%2C+Kevin%3BPrisinzano%2C+Thomas+E%3BBohn%2C+Laura+M%3BRothman%2C+Richard+B&rft.aulast=Xu&rft.aufirst=Heng&rft.date=2007-03-01&rft.volume=61&rft.issue=3&rft.spage=166&rft.isbn=&rft.btitle=&rft.title=Synapse+%28New+York%2C+N.Y.%29&rft.issn=08874476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-27 N1 - Date created - 2007-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Serving our colleagues: reference and history of medicine services from the National Library of Medicine. AN - 57675995; 00494507 AB - Most biomedical librarians are frequent users of the major online services provided by the National Library of Medicine (NLM), part of the National Institutes of Health in Bethesda, Maryland. These services include MEDLINE/PubMed, MedlinePlus, ClinicalTrials.gov, PubMed Central, document delivery, and other key biomedical resources. This article highlights less well-known services from reference, to historical information, to training and other services which librarians may not be aware the NLM offers to them. NLM encourages librarians to consider that NLM's unique and unsurpassed collection can help when local resources may be too limited to serve the needs of their patrons. (Copies of this article are available for a fee from the Haworth Document Delivery Service, Haworth Press, Inc. E-Mail: getinfo@haworthpressinc.com, Web site http://www.HaworthPress.com). (Author abstract) JF - Medical Reference Services Quarterly AU - Burke, Cynthia AU - Greenberg, Stephen AU - Ahmed, Terry AD - National Library of Medicine, Reference and Web Services Section, 8600 Rockville Pike. Room 1W22, Bethesda, MD 20894 burkec1@mail.nlm.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 73 EP - 80 PB - Haworth Press Inc VL - 26 IS - 1 SN - 0276-3869, 0276-3869 KW - User services KW - National Library of Medicine, USA KW - Online reference work KW - History KW - Electronic information services KW - Medical informatics KW - 10.15: REFERENCE WORK UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57675995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Reference+Services+Quarterly&rft.atitle=Serving+our+colleagues%3A+reference+and+history+of+medicine+services+from+the+National+Library+of+Medicine.&rft.au=Burke%2C+Cynthia%3BGreenberg%2C+Stephen%3BAhmed%2C+Terry&rft.aulast=Burke&rft.aufirst=Cynthia&rft.date=2007-03-01&rft.volume=26&rft.issue=1&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Medical+Reference+Services+Quarterly&rft.issn=02763869&rft_id=info:doi/10.1300%2FJ115v26n01_07 LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2007-05-28 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Medical informatics; Electronic information services; Online reference work; User services; National Library of Medicine, USA; History DO - http://dx.doi.org/10.1300/J115v26n01_07 ER - TY - JOUR T1 - Aesthetic Chills as a Universal Marker of Openness to Experience AN - 57236073; 200809243 AB - Aesthetic chills are transient emotional responses to music or other experiences of beauty. Item 188 of the Revised NEO Personality Inventory (NEO-PI-R) asks respondents if they have experienced these chills, and in American samples it is one of the best definers of Openness to Experience, one of the five basic personality factors. As part of the NEO-PI-R, the item has been translated into over 40 languages, and an examination of back-translations suggests that the phenomenon can be expressed in all the languages examined. Data from the Personality Profiles of Cultures Project show that Item 188 is one of the best definers of Openness in most of the 51 cultures examined. Aesthetic chills appear to be a universal emotional experience, although the functions they serve and the mechanisms that account for them remain to be discovered. Adapted from the source document. JF - Motivation and Emotion AU - McCrae, Robert R AD - Laboratory of Personality and Cognition, Gerontology Research Center, National Institute on Aging, Box #03, 5600 Nathan Shock Drive, Baltimore, MD 21224-6825, USA mccraej@grc.nia.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 5 EP - 11 PB - Springer Science+Business Media, Inc, New York, NY VL - 31 IS - 1 SN - 0146-7239, 0146-7239 KW - Openness KW - Five factor model KW - Emotional responses KW - Music KW - Beauty KW - Aesthetics KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57236073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Motivation+and+Emotion&rft.atitle=Aesthetic+Chills+as+a+Universal+Marker+of+Openness+to+Experience&rft.au=McCrae%2C+Robert+R&rft.aulast=McCrae&rft.aufirst=Robert&rft.date=2007-03-01&rft.volume=31&rft.issue=1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Motivation+and+Emotion&rft.issn=01467239&rft_id=info:doi/10.1007%2Fs11031-007-9053-1 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-05-02 N1 - Last updated - 2016-09-27 N1 - CODEN - MOEMDJ N1 - SubjectsTermNotLitGenreText - Aesthetics; Beauty; Emotional responses; Openness; Five factor model; Music DO - http://dx.doi.org/10.1007/s11031-007-9053-1 ER - TY - JOUR T1 - Personality Traits in Sardinia: Testing Founder Population Effects on Trait Means and Variances AN - 57228502; 200716737 AB - Potential founder population effects on personality trait means and variances were examined in a large, genetically homogeneous sample (N = 5,669) from the Ogliastra, an isolated region within Sardinia, Italy. The Italian version of the Revised NEO Personality Inventory showed good psychometric properties: Internal consistency reliabilities ranged from 0.80 to 0.87; the factor structure replicated the American normative structure; and associations with education and gender replicated cross-cultural patterns. The hypothesis that means trait levels in the Sardinian founder population would differ from mainland Italian values was not supported. Phenotypic variation in this founder population was within the range found in other cultures. However, the hypothesis of restricted phenotypic variation was supported for all five factors and 28 of the 30 facets when a Sardinian subsample matched on age, sex, and education was compared to a mainland Italian sample. The genetic homogeneity effect on the phenotypic expression of complex traits merits further exploration. Adapted from the source document. JF - Behavior Genetics AU - Costa, Paul T, Jr AU - Terracciano, Antonio AU - Uda, Manuela AU - Vacca, Loredana AU - Mameli, Cinzia AU - Pilia, Giuseppe AU - Zonderman, Alan B AU - Lakatta, Edward AU - Schlessinger, David AU - McCrae, Robert R AD - National Instit Aging, NIH, DHHS, Baltimore, MD costap@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 376 EP - 387 PB - Springer Science+Business Media, Inc, New York, NY VL - 37 IS - 2 SN - 0001-8244, 0001-8244 KW - Five-Factor Model of personality, Genetic homogeneity, Founder population, Cross-cultural, Complex trait, QTL KW - Five factor model KW - Personality KW - Psychometric properties KW - Genetic family histories KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57228502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavior+Genetics&rft.atitle=Personality+Traits+in+Sardinia%3A+Testing+Founder+Population+Effects+on+Trait+Means+and+Variances&rft.au=Costa%2C+Paul+T%2C+Jr%3BTerracciano%2C+Antonio%3BUda%2C+Manuela%3BVacca%2C+Loredana%3BMameli%2C+Cinzia%3BPilia%2C+Giuseppe%3BZonderman%2C+Alan+B%3BLakatta%2C+Edward%3BSchlessinger%2C+David%3BMcCrae%2C+Robert+R&rft.aulast=Costa&rft.aufirst=Paul&rft.date=2007-03-01&rft.volume=37&rft.issue=2&rft.spage=376&rft.isbn=&rft.btitle=&rft.title=Behavior+Genetics&rft.issn=00018244&rft_id=info:doi/10.1007%2Fs10519-006-9103-6 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-09-28 N1 - Last updated - 2016-09-27 N1 - CODEN - BHGHAT N1 - SubjectsTermNotLitGenreText - Five factor model; Personality; Genetic family histories; Psychometric properties DO - http://dx.doi.org/10.1007/s10519-006-9103-6 ER - TY - JOUR T1 - Befriending patients with medication-resistant schizophrenia: Can psychotic symptoms predict treatment response? AN - 57225854; 200717848 AB - Objectives: Supportive interventions are used in schizophrenia, but little research has been conducted into whether any baseline variable predicts treatment response. The aim of this study was to establish if baseline delusions or hallucinations are associated with changes in overall symptoms in patients who received a befriending intervention. Design: The sample consisted of 44 patients with schizophrenia. These patients comprised the befriending arm of a multicentre randomized controlled trial which compared the efficacy of using CBT against befriending as an adjunct to routine care for patients with medication-resistant schizophrenia. Methods: Scores for auditory hallucinations and delusions relating to persecution or control were entered into two regression models. The dependent variables were change in overall symptoms (1) between baseline and end of the intervention, and (2) between baseline and 9 months post-intervention. Results: Baseline delusions predicted a good response and auditory hallucinations predicted a poor response at 9 months. Conclusions: Baseline psychotic symptoms strongly predicted outcome in this sample. The finding that hallucinations predicted a poor outcome is consistent with previous research. These results may help to determine which patients would benefit from supportive interventions. Adapted from the source document. JF - Psychology and Psychotherapy: Theory, Research and Practice AU - Samarasekera, N AU - Kingdon, D AU - Siddle, R AU - O'Carroll, M AU - Scott, J L AU - Sensky, T AU - Barnes, T R E AU - Turkington, D AD - Dept Psychiatry Royal Victoria Infirmary, Newcastle-Upon-Tyne NEI 4LP UK Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 97 EP - 106 PB - The British Psychological Society, Leicester UK VL - 80 IS - 1 SN - 1476-0835, 1476-0835 KW - Schizophrenia KW - Cognitive behaviour therapy KW - Drug resistant KW - Auditory hallucinations KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57225854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+and+Psychotherapy%3A+Theory%2C+Research+and+Practice&rft.atitle=Befriending+patients+with+medication-resistant+schizophrenia%3A+Can+psychotic+symptoms+predict+treatment+response%3F&rft.au=Samarasekera%2C+N%3BKingdon%2C+D%3BSiddle%2C+R%3BO%27Carroll%2C+M%3BScott%2C+J+L%3BSensky%2C+T%3BBarnes%2C+T+R+E%3BTurkington%2C+D&rft.aulast=Samarasekera&rft.aufirst=N&rft.date=2007-03-01&rft.volume=80&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Psychology+and+Psychotherapy%3A+Theory%2C+Research+and+Practice&rft.issn=14760835&rft_id=info:doi/10.1348%2F147608306X108998 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-09-28 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Schizophrenia; Auditory hallucinations; Drug resistant; Cognitive behaviour therapy DO - http://dx.doi.org/10.1348/147608306X108998 ER - TY - JOUR T1 - Age Differences in Recognition of Emotion in Lexical Stimuli and Facial Expressions AN - 57224116; 200715458 AB - Age differences in emotion recognition from lexical stimuli and facial expressions were examined in a cross-sectional sample of adults aged 18 to 85 (N = 357). Emotion-specific response biases differed by age: Older adults were disproportionately more likely to incorrectly label lexical stimuli as happiness, sadness, and surprise and to incorrectly label facial stimuli as disgust and fear. After these biases were controlled, findings suggested that older adults were less accurate at identifying emotions than were young adults, but the pattern differed across emotions and task types. The lexical task showed stronger age differences than the facial task, and for lexical stimuli, age groups differed in accuracy for all emotional states except fear. For facial stimuli, in contrast, age groups differed only in accuracy for anger, disgust, fear, and happiness. Implications for age-related changes in different types of emotional processing are discussed. [Copyright 2007 American Psychological Association.] JF - Psychology and Aging AU - Isaacowitz, Derek M AU - Lockenhoff, Corinna E AU - Lane, Richard D AU - Wright, Ron AU - Sechrest, Lee AU - Riedel, Robert AU - Costa, Paul T AD - Laboratory Personality & Cognition, National Instit Aging, Triad Technology Center, Baltimore, MD e-mall: costap@grc.nia.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 147 EP - 159 PB - American Psychological Association, Washington DC VL - 22 IS - 1 SN - 0882-7974, 0882-7974 KW - emotion recognition, facial expressions, lexical stimuli, aging KW - Lexical processing KW - Facial expressions KW - Emotion recognition KW - Age differences KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57224116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychology+and+Aging&rft.atitle=Age+Differences+in+Recognition+of+Emotion+in+Lexical+Stimuli+and+Facial+Expressions&rft.au=Isaacowitz%2C+Derek+M%3BLockenhoff%2C+Corinna+E%3BLane%2C+Richard+D%3BWright%2C+Ron%3BSechrest%2C+Lee%3BRiedel%2C+Robert%3BCosta%2C+Paul+T&rft.aulast=Isaacowitz&rft.aufirst=Derek&rft.date=2007-03-01&rft.volume=22&rft.issue=1&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Psychology+and+Aging&rft.issn=08827974&rft_id=info:doi/10.1037%2F0882-7974.22.1.147 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-08-28 N1 - Last updated - 2016-09-27 N1 - CODEN - PAGIEL N1 - SubjectsTermNotLitGenreText - Age differences; Lexical processing; Facial expressions; Emotion recognition DO - http://dx.doi.org/10.1037/0882-7974.22.1.147 ER - TY - JOUR T1 - Cognitive Flexibility in Phenotypes of Pediatric Bipolar Disorder AN - 57222263; 200715113 AB - Objective: Clinicians and researchers debate whether children with chronic, nonepisodic irritability should receive the diagnosis of bipolar disorder (BD). To address this debate, we evaluated cognitive flexibility, or the ability to adapt to changing contingencies, in three groups of children: narrow-phenotype BD (NP-BD full-duration manic episodes of elevated/expansive mood; N = 50; 13.1 - 2.9 years), severe mood dysregulation (SMD; chronic, nonepisodic irritability; N = 44; 12.2 - 2.1 years), and healthy controls (N = 43; 13.6 - 2.4 years). Cognitive flexibility is relevant to symptoms of BD involving dysfunctional reward systems (e.g., excessive goal-directed activity and pleasure-seeking in mania; anhedonia in depression). Method: We studied simple and compound reversal stages of the intra-/extradimensional shift task and change task that involves inhibiting a prepotent response and substituting a novel response. Results: On the simple reversal, NP-BD youths were significantly more impaired than both the SMD group and controls. On the compound reversal, NP-BD and SMD youths performed worse than controls. On the change task, NP-BD youths were slower to adapt than SMD subjects. Conclusions: Phenotypic differences in cognitive flexibility may reflect different brain/behavior mechanisms in these two patient populations. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Dickstein, Daniel P AU - Nelson, Eric E AU - McClure, Erin AU - Grimley, Mary E AU - Knopf, Lisa AU - Brotman, Melissa A AU - Rich, Brendan A AU - Pine, Daniel S AU - Leibenluft, Ellen AD - National Institute of Mental Health, Pediatrics & Developmental Neuropsychiatry Branch, 9000 Rockville Pike MSC 2670 Building 15K Room 204, Bethesda MD 20892-2670 E-mail: Dicksted@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 341 EP - 355 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 46 IS - 3 SN - 0890-8567, 0890-8567 KW - bipolar disorder, neuropsychological tests, cognition KW - Irritability KW - Neuropsychological tests KW - Bipolar affective disorder KW - Child psychiatry KW - Cognitive functioning KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57222263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Cognitive+Flexibility+in+Phenotypes+of+Pediatric+Bipolar+Disorder&rft.au=Dickstein%2C+Daniel+P%3BNelson%2C+Eric+E%3BMcClure%2C+Erin%3BGrimley%2C+Mary+E%3BKnopf%2C+Lisa%3BBrotman%2C+Melissa+A%3BRich%2C+Brendan+A%3BPine%2C+Daniel+S%3BLeibenluft%2C+Ellen&rft.aulast=Dickstein&rft.aufirst=Daniel&rft.date=2007-03-01&rft.volume=46&rft.issue=3&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2Fchi.0b013e31802d0b3d LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-08-28 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Child psychiatry; Bipolar affective disorder; Cognitive functioning; Irritability; Neuropsychological tests DO - http://dx.doi.org/10.1097/chi.0b013e31802d0b3d ER - TY - JOUR T1 - Aggression, psychopathy and free will from a cognitive neuroscience perspective AN - 57102910; 200801550 AB - This article considers the notion of free will in the context of aggression and psychopathy research. The philosophical literature is very briefly considered to determine under what assumptions free will can be considered to exist. However, as the issue of free will is very difficult to address directly, the prime focus of this article is on issues raised in the philosophical debate, that may be empirically tractable and that are relevant to the understanding of psychopathy. Specifically, the following issues are considered: (1) The distinction between automatic and controlled processing; (2) Impairment related to automatic processing in individuals with psychopathy; and (3) Impairment related to controlled behavior in individuals with psychopathy. It is concluded that, while there is not a direct mapping of the automatic versus controlled processing dichotomy on to the reactive versus instrumental aggression dichotomy, some overlap can be considered. As such, it is possible to consider that certain episodes of reactive aggression might be considered to occur in the absence of free will. However, instrumental aggression, at least from a compatibilist perspective, must involve free will. Published in 2007 by John Wiley & Sons, Ltd. [Copyright 2007 John Wiley and Sons, Ltd.] JF - Behavioral Sciences & the Law AU - Blair, R J R Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 321 EP - 331 PB - John Wiley & Sons, Chichester UK VL - 25 IS - 2 SN - 0735-3936, 0735-3936 KW - Automatic processes KW - Psychopathy KW - Neurosciences KW - Aggression KW - Cognition KW - Free will KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57102910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+Sciences+%26+the+Law&rft.atitle=Aggression%2C+psychopathy+and+free+will+from+a+cognitive+neuroscience+perspective&rft.au=Blair%2C+R+J+R&rft.aulast=Blair&rft.aufirst=R+J&rft.date=2007-03-01&rft.volume=25&rft.issue=2&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Behavioral+Sciences+%26+the+Law&rft.issn=07353936&rft_id=info:doi/10.1002%2Fbsl.750 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-02-04 N1 - Last updated - 2016-09-27 N1 - CODEN - BSLADR N1 - SubjectsTermNotLitGenreText - Free will; Psychopathy; Aggression; Neurosciences; Cognition; Automatic processes DO - http://dx.doi.org/10.1002/bsl.750 ER - TY - JOUR T1 - Socioeconomic Status and Financial Coping Strategies: The Mediating Role of Perceived Control AN - 57092559; 200800187 AB - We examine the relations among socioeconomic status, control beliefs, and two coping styles (problem-focused vs. emotion-focused) in the context of financial stress. Findings indicate that low socioeconomic status (SES) is linked to greater use of emotion-focused financial coping and lesser use of problem-focused financial coping. The effects of SES on the use of problem-focused financial coping appear to be entirely mediated by two measures of perceived control: self-confidence and fatalism. In contrast, the effects of SES on emotion- focused financial coping are not mediated in this way. Results also indicated that problem-focused and emotion-focused financial coping are differentially related to financial stress and to general psychosocial distress. These results suggest that low SES may decrease one s control beliefs, which in turn decrease the likelihood of choosing effective financial coping processes, resulting in double disadvantage. Adapted from the source document. JF - Social Psychology Quarterly AU - Caplan, Leslie J AU - Schooler, Carmi AD - Section on Socio-Environmental Studies, National Institute of Mental Health, 6101 Executive Blvd., Room 364, Bethesda MD 20892-8408 E-mail: leslie.caplan@nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 43 EP - 58 PB - American Sociological Association, Washington DC VL - 70 IS - 1 SN - 0190-2725, 0190-2725 KW - Coping strategies KW - Perceived control KW - Socioeconomic status KW - Economic stress KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57092559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Psychology+Quarterly&rft.atitle=Socioeconomic+Status+and+Financial+Coping+Strategies%3A+The+Mediating+Role+of+Perceived+Control&rft.au=Caplan%2C+Leslie+J%3BSchooler%2C+Carmi&rft.aulast=Caplan&rft.aufirst=Leslie&rft.date=2007-03-01&rft.volume=70&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Social+Psychology+Quarterly&rft.issn=01902725&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-01-04 N1 - Last updated - 2016-09-27 N1 - CODEN - SPQUD6 N1 - SubjectsTermNotLitGenreText - Socioeconomic status; Coping strategies; Perceived control; Economic stress ER - TY - JOUR T1 - Is There A Future For Quantifying Drinking In The Diagnosis, Treatment, And Prevention Of Alcohol Use Disorders? AN - 57059413; 200719204 AB - This commentary is based on a Plenary Address at the 2006 Meeting of the International Society for Biomedical Research on Alcoholism (ISBRA) held in Sydney, Australia, which posed the simple question: Is There a Future for Quantifying Drinking in the Diagnosis, Treatment, and Prevention of Alcohol Use Disorders? The intention is to stimulate dialogue among the many disciplines represented in the alcohol field about where we should be going with respect to diagnostic criteria for alcohol use disorders (AUDs), now that the American Psychiatric Association (APA) and the World Health Organization (WHO) have launched initiatives for the construction of the fifth revision of the APA Diagnostic and Statistical Manual (DSM-V) and the 11th edition of the WHO International Classification of Diseases (ICD-11). Adapted from the source document. JF - Alcohol and Alcoholism AU - Li, Ting-Kai AU - Hewitt, Brenda G AU - Grant, Bridget F AD - National Instit on Alcohol Abuse & Alcoholism, National Instit of Health, U. S. Dept of Health & Human Services, Bethesda, MD Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 57 EP - 63 PB - Oxford University Press, UK VL - 42 IS - 2 SN - 0735-0414, 0735-0414 KW - World Health Organization KW - Prevention KW - Diagnosis KW - Alcoholism KW - Treatment KW - American Psychiatric Association KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57059413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+and+Alcoholism&rft.atitle=Is+There+A+Future+For+Quantifying+Drinking+In+The+Diagnosis%2C+Treatment%2C+And+Prevention+Of+Alcohol+Use+Disorders%3F&rft.au=Li%2C+Ting-Kai%3BHewitt%2C+Brenda+G%3BGrant%2C+Bridget+F&rft.aulast=Li&rft.aufirst=Ting-Kai&rft.date=2007-03-01&rft.volume=42&rft.issue=2&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Alcohol+and+Alcoholism&rft.issn=07350414&rft_id=info:doi/10.1093%2Falcalc%2Fagl125 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-11-01 N1 - Last updated - 2016-09-27 N1 - CODEN - ALALDD N1 - SubjectsTermNotLitGenreText - Alcoholism; American Psychiatric Association; Diagnosis; Treatment; Prevention; World Health Organization DO - http://dx.doi.org/10.1093/alcalc/agl125 ER - TY - JOUR T1 - Integrating earth science and epidemiology; modeling the probability of arsenic in New England groundwater for exposure assessment AN - 50863340; 2008-095445 AB - For over five decades, the states of Maine, New Hampshire, and Vermont reported excess mortality rates from bladder cancer in males and females. One hypothesized explanation for this excess is the presence of elevated concentrations in drinking water of inorganic arsenic, a substance known as a bladder carcinogen at high levels. In northern New England, about 40% of residents use private wells, and in some areas more than 30% of private wells have inorganic arsenic concentrations that exceed the drinking water standard of 10 mu g/L. Recent ecological evidence suggests that bladder cancer mortality in the region is correlated with private well use. An epidemiologic study of bladder cancer in northern New England is underway. The purpose is to explain the excess of bladder cancer, with a major focus on the risk of long-term consumption of arsenic in drinking water. The study includes an estimate of arsenic exposure and exposure uncertainty during adult life for each study subject based on residential history, arsenic concentrations in drinking water wells at current and past residences, and water-quality and use data from public water supplies. In some cases, there are gaps in the exposure profile because of unavailable data. To estimate arsenic concentrations in the gaps, a process-based statistical model has been developed to identify geographic areas in New England with a probability of arsenic concentrations exceeding 5 mu g/L in drinking water wells. In the model, multivariate logistic regression is used to estimate the probability of occurrence of elevated arsenic concentrations in ground water. The model is based on geologic, hydrologic, and landscape information, including specific geologic formation units, arsenic concentrations in stream sediments, areas of Pleistocene marine inundation, and proximity to intrusive granitic plutons. These and other hydrologic and landscape variables related to arsenic sources and ground-water geochemical factors and residence time are shown to increase the probability of elevated arsenic concentrations in ground water. Previous studies suggest that arsenic in bedrock ground water may be partly from past arsenical pesticide use but variables representing historic agricultural inputs do not improve the model, indicating that this source does not significantly contribute to current arsenic concentrations. JF - Abstracts with Programs - Geological Society of America AU - Ayotte, Joseph D AU - Nuckols, John R AU - Cantor, Kenneth P AU - Robinson, Gilpin R AU - Baris, Dalsu AU - Hayes, Laura AU - Karagas, Margaret AU - Bress, Bill AU - Silverman, Debra AU - Lubin, Jay AU - Anonymous Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 56 EP - 57 PB - Geological Society of America (GSA), Boulder, CO VL - 39 IS - 1 SN - 0016-7592, 0016-7592 KW - United States KW - medical geology KW - drinking water KW - ground water KW - New Hampshire KW - Cenozoic KW - carcinogens KW - New England KW - ecology KW - bedrock KW - concentration KW - water supply KW - toxic materials KW - Quaternary KW - arsenic KW - pollution KW - Vermont KW - aquifers KW - models KW - metals KW - Pleistocene KW - risk assessment KW - pesticides KW - Maine KW - water wells KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50863340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Integrating+earth+science+and+epidemiology%3B+modeling+the+probability+of+arsenic+in+New+England+groundwater+for+exposure+assessment&rft.au=Ayotte%2C+Joseph+D%3BNuckols%2C+John+R%3BCantor%2C+Kenneth+P%3BRobinson%2C+Gilpin+R%3BBaris%2C+Dalsu%3BHayes%2C+Laura%3BKaragas%2C+Margaret%3BBress%2C+Bill%3BSilverman%2C+Debra%3BLubin%2C+Jay%3BAnonymous&rft.aulast=Ayotte&rft.aufirst=Joseph&rft.date=2007-03-01&rft.volume=39&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, Northeastern Section, 42nd annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2008-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - aquifers; arsenic; bedrock; carcinogens; Cenozoic; concentration; drinking water; ecology; ground water; Maine; medical geology; metals; models; New England; New Hampshire; pesticides; Pleistocene; pollution; Quaternary; risk assessment; toxic materials; United States; Vermont; water supply; water wells ER - TY - JOUR T1 - Mercury-selenium association in Antarctic seal hairs and animal excrements over the past 1,500 years AN - 50622233; 2008-111694 AB - Strong positive correlations between selenium (Se) and total mercury (HgT) contents in the liver of marine mammals and mercury mine workers in modern times have been documented in numerous investigations. Herein, we report a positive correlation between Se and HgT concentrations over the past 1,500 years in the seal hairs and in the lake sediments amended by seal or penguin excrements on King George Island (63 degrees 23'S, 57 degrees 00'W), West Antarctica. Because the changes in the input of Se and Hg into the marine environments of the studied sites do not seem to be synchronous, this striking correlation indicates a self-protection mechanism in Antarctic seals and penguins: Every time there is heavier Hg burden, more Se is accumulated to reduce the toxicity of Hg. This positive correlation between Hg and Se contents in the seal hairs and excrement sediments, however, becomes insignificant in the recent 50 years for unknown reasons. JF - Environmental Toxicology and Chemistry AU - Yin, Xuebin AU - Sun, Liguang AU - Zhu, Renbin AU - Liu, Xiaodong AU - Ruan, Diyun AU - Wang, Yuhong Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 381 EP - 386 PB - SETAC, Pensacola, FL VL - 26 IS - 3 SN - 0730-7268, 0730-7268 KW - sea water KW - selenium KW - Pinnipedia KW - Holocene KW - Ardley Island KW - Fildes Peninsula KW - bioaccumulation KW - Cenozoic KW - Theria KW - King George Island KW - toxicity KW - South Shetland Islands KW - noble gases KW - helium KW - ecology KW - Eutheria KW - Chordata KW - Quaternary KW - Carnivora KW - Mammalia KW - correlation KW - indicators KW - biota KW - adaptation KW - habitat KW - Antarctica KW - marine environment KW - lacustrine environment KW - Vertebrata KW - upper Holocene KW - Scotia Sea Islands KW - Tetrapoda KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50622233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Chemistry&rft.atitle=Mercury-selenium+association+in+Antarctic+seal+hairs+and+animal+excrements+over+the+past+1%2C500+years&rft.au=Yin%2C+Xuebin%3BSun%2C+Liguang%3BZhu%2C+Renbin%3BLiu%2C+Xiaodong%3BRuan%2C+Diyun%3BWang%2C+Yuhong&rft.aulast=Yin&rft.aufirst=Xuebin&rft.date=2007-03-01&rft.volume=26&rft.issue=3&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Chemistry&rft.issn=07307268&rft_id=info:doi/10.1897%2F06-128 L2 - http://www3.interscience.wiley.com/journal/122563640/home?CRETRY=1&SRETRY=0 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2008-01-01 N1 - Number of references - 40 N1 - PubXState - FL N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - adaptation; Antarctica; Ardley Island; bioaccumulation; biota; Carnivora; Cenozoic; Chordata; correlation; ecology; Eutheria; Fildes Peninsula; habitat; helium; Holocene; indicators; King George Island; lacustrine environment; Mammalia; marine environment; noble gases; Pinnipedia; Quaternary; Scotia Sea Islands; sea water; selenium; South Shetland Islands; Tetrapoda; Theria; toxicity; upper Holocene; Vertebrata DO - http://dx.doi.org/10.1897/06-128 ER - TY - CPAPER T1 - Health Behaviors and Health-Related Quality of Life of Adult Non-Hodgkin Lymphoma Survivors: Results from the ECHOS-NHL Study T2 - 4th Annual Conference of the American Psychosocial Oncology Society AN - 40589321; 4551902 JF - 4th Annual Conference of the American Psychosocial Oncology Society AU - Bellizzi, Keith Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 KW - Lymphoma KW - Quality of life KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40589321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+Conference+of+the+American+Psychosocial+Oncology+Society&rft.atitle=Health+Behaviors+and+Health-Related+Quality+of+Life+of+Adult+Non-Hodgkin+Lymphoma+Survivors%3A+Results+from+the+ECHOS-NHL+Study&rft.au=Bellizzi%2C+Keith&rft.aulast=Bellizzi&rft.aufirst=Keith&rft.date=2007-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+Conference+of+the+American+Psychosocial+Oncology+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.apos-society.org/professionals/meetings-ed/conference/2007/ 2007-schedule-details.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Risk Perception, Self-Efficacy and Cancer Survivorship: Testing the Risk Perception Attitude Framework in Adult Cancer Survivors T2 - 4th Annual Conference of the American Psychosocial Oncology Society AN - 40589110; 4551933 JF - 4th Annual Conference of the American Psychosocial Oncology Society AU - Beckjord, Ellen Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 KW - Cancer KW - Perception KW - Attitudes KW - Survival KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40589110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention+in+Association+with+the+Council+on+Nutrition%2C+Physical+Activity%2C+and+Metabolism&rft.atitle=Genome-wide+Association+with+Adiposity-related+Traits%3A+The+Framingham+Heart+Study+100K+Project&rft.au=Fox%2C+Caroline+S%3BHeard-Costa%2C+Nancy%3BCupples%2C+L+Adrienne%3BDupuis%2C+Josee%3BVasan%2C+Ramachandran+S%3BAtwood%2C+Larry+D&rft.aulast=Fox&rft.aufirst=Caroline&rft.date=2007-02-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention+in+Association+with+the+Council+on+Nutrition%2C+Physical+Activity%2C+and+Metabolism&rft.issn=&rft_id=info:doi/ L2 - http://www.apos-society.org/professionals/meetings-ed/conference/2007/ 2007-schedule-details.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Are Cancer Survivors Receiving Adequate Communication about Medical Tests and Symptoms Management from Their Follow-Up Care Physicians? T2 - 4th Annual Conference of the American Psychosocial Oncology Society AN - 40589034; 4551918 JF - 4th Annual Conference of the American Psychosocial Oncology Society AU - Arora, Neeraj Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 KW - Cancer KW - Communication KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40589034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+Conference+of+the+American+Psychosocial+Oncology+Society&rft.atitle=Are+Cancer+Survivors+Receiving+Adequate+Communication+about+Medical+Tests+and+Symptoms+Management+from+Their+Follow-Up+Care+Physicians%3F&rft.au=Arora%2C+Neeraj&rft.aulast=Arora&rft.aufirst=Neeraj&rft.date=2007-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+Conference+of+the+American+Psychosocial+Oncology+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.apos-society.org/professionals/meetings-ed/conference/2007/ 2007-schedule-details.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Influence of Baseline Psychosocial Well-Being on Hospitalization and Survival following Allogeneic Hematopoietic Stem Cell Transplantation T2 - 4th Annual Conference of the American Psychosocial Oncology Society AN - 40588995; 4551903 JF - 4th Annual Conference of the American Psychosocial Oncology Society AU - Bevans, Margaret Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 KW - Stem cells KW - Survival KW - Cell survival KW - Transplantation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40588995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention+in+Association+with+the+Council+on+Nutrition%2C+Physical+Activity%2C+and+Metabolism&rft.atitle=Subcutaneous+and+Visceral+Adipose+Tissue+and+their+Association+with+Coronary+and+Aortic+Artery+Calcification%3A+The+Framingham+Heart+Study&rft.au=Fox%2C+Caroline+S%3BHwang%2C+Shih-Jen%3BMassaro%2C+Joseph+M%3BPou%2C+Karla+M%3BLarson%2C+Martin+G%3BHoffmann%2C+Udo%3BO%27Donnell%2C+Christopher+J&rft.aulast=Fox&rft.aufirst=Caroline&rft.date=2007-02-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention+in+Association+with+the+Council+on+Nutrition%2C+Physical+Activity%2C+and+Metabolism&rft.issn=&rft_id=info:doi/ L2 - http://www.apos-society.org/professionals/meetings-ed/conference/2007/ 2007-schedule-details.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Language barriers surrounding medication use among older Latinos AN - 36755588; 3470877 AB - Limited English language proficiency forms a significant challenge for many Latinos in clinical settings. Although medications are commonly used by older individuals as a means of maintaining good health and managing health problems, the extent to which English proficiency is related to medication use among older Latinos is not known. Focus groups were conducted with Latino, community-residing individuals aged 50 and over in eastern Massachusetts. Qualitative evaluation of the group interviews suggests that language is a barrier in dealing with medication for these individuals. Limited English proficiency appears to be related to feelings of being discriminated against in clinical and pharmacy settings. As well, communicating directly with health professionals in a common language is associated with level of trust and confidence in medical settings. Use of formal and informal interpreters, as well as seeking Spanish-speaking physicians and pharmacies with Spanish-speaking staff, are identified as strategies for overcoming health-related obstacles surrounding language. Reprinted by permission of Springer JF - Journal of cross-cultural gerontology AU - Mutchler, Jan E AU - Bacigalupe, Gonzalo AU - Coppin, Antonia AU - Gottlieb, Alison AD - University of Massachusetts, Boston ; University of Massachusetts ; National Institute on Aging, Bethesda Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 101 EP - 114 VL - 22 IS - 1 SN - 0169-3816, 0169-3816 KW - Anthropology KW - Sociology KW - Spanish language KW - Health care KW - Trust KW - Communication KW - Old age KW - English language KW - Health inequality KW - Hispanics KW - Ethnic groups UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36755588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cross-cultural+gerontology&rft.atitle=Language+barriers+surrounding+medication+use+among+older+Latinos&rft.au=Mutchler%2C+Jan+E%3BBacigalupe%2C+Gonzalo%3BCoppin%2C+Antonia%3BGottlieb%2C+Alison&rft.aulast=Mutchler&rft.aufirst=Jan&rft.date=2007-03-01&rft.volume=22&rft.issue=1&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Journal+of+cross-cultural+gerontology&rft.issn=01693816&rft_id=info:doi/10.1007%2Fs10823-006-9021-3 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4290 4535 7226 5492 6331; 2572; 13012; 5775 13521; 12101 4535 7226 11132 6331; 5783 5772 6489; 4424; 8911 602 652 5676 646 6091; 5865 4424 DO - http://dx.doi.org/10.1007/s10823-006-9021-3 ER - TY - JOUR T1 - Teachers' education, classroom quality, and young children's academic skills: results from seven studies of preschool programs AN - 36638069; 3410533 AB - In an effort to provide high-quality preschool education, policymakers are increasingly requiring public preschool teachers to have at least a Bachelor's degree, preferably in early childhood education. Seven major studies of early care and education were used to predict classroom quality and children's academic outcomes from the educational attainment and major of teachers of 4-year-olds. The findings indicate largely null or contradictory associations, indicating that policies focused solely on increasing teachers' education will not suffice for improving classroom quality or maximizing children's academic gains. Instead, education will not suffice of improving classroom quality or maximizing children's academic gains. Instead, raising the effectiveness of early childhood education will require a broad range of professional development activities and supports targeted toward teacher's toward teachers' interactions with children. Reprinted by permission of the University of Chicago Press. © All rights reserved JF - Child development AU - Early, Diane M AU - Maxwell, Kelly L AU - Burchinal, Margaret AU - Alva, Soumya AU - Bender, Randall H AU - Bryant, Donna AU - Cai, Karen AU - Clifford, Richard M AU - Ebanks, Caroline AU - Griffin, James A AU - Henry, Gary T AU - Howes, Carollee AU - Iriondo-Perez, Jeniffer AU - Jeon, Hyun-Joo AU - Mashburn, Andrew J AU - Peisner-Feinberg, Ellen AU - Pianta, Robert C AU - Vandergrift, Nathan AU - Zill, Nicholas AD - University of North Carolina, Chapel Hill ; Westat Inc. ; RTI International ; US Department of Education ; National Institutes of Health ; University of California, Los Angeles ; University of Virginia Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 558 EP - 580 VL - 78 IS - 2 SN - 0009-3920, 0009-3920 KW - Sociology KW - Qualitative analysis KW - Academic achievement KW - Pre-school education KW - Teacher training KW - Social interaction KW - Classrooms KW - Child development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36638069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+development&rft.atitle=Teachers%27+education%2C+classroom+quality%2C+and+young+children%27s+academic+skills%3A+results+from+seven+studies+of+preschool+programs&rft.au=Early%2C+Diane+M%3BMaxwell%2C+Kelly+L%3BBurchinal%2C+Margaret%3BAlva%2C+Soumya%3BBender%2C+Randall+H%3BBryant%2C+Donna%3BCai%2C+Karen%3BClifford%2C+Richard+M%3BEbanks%2C+Caroline%3BGriffin%2C+James+A%3BHenry%2C+Gary+T%3BHowes%2C+Carollee%3BIriondo-Perez%2C+Jeniffer%3BJeon%2C+Hyun-Joo%3BMashburn%2C+Andrew+J%3BPeisner-Feinberg%2C+Ellen%3BPianta%2C+Robert+C%3BVandergrift%2C+Nathan%3BZill%2C+Nicholas&rft.aulast=Early&rft.aufirst=Diane&rft.date=2007-03-01&rft.volume=78&rft.issue=2&rft.spage=558&rft.isbn=&rft.btitle=&rft.title=Child+development&rft.issn=00093920&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 2197 2212 6075 3483; 12586 12894; 10002 4049; 501 542 8322; 2362 11324; 11860 11907; 10519 3279 971 3286 ER - TY - JOUR T1 - Prediction of U.S. cancer mortality counts using semiparametric Bayesian techniques AN - 36605401; 3392675 JF - Journal of the American Statistical Association AU - Ghosh, Kaushik AU - Tiwari, Ram C AD - New Jersey Institute of Technology ; US National Cancer Institute Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 7 EP - 15 VL - 102 IS - 477 SN - 0162-1459, 0162-1459 KW - Economics KW - Monte Carlo simulation KW - Forecasts KW - Mortality KW - Statistics KW - Time series KW - Linear models KW - U.S.A. KW - Statistical methods KW - Cancer KW - Markovian processes KW - Bayesian method UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36605401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Statistical+Association&rft.atitle=Prediction+of+U.S.+cancer+mortality+counts+using+semiparametric+Bayesian+techniques&rft.au=Ghosh%2C+Kaushik%3BTiwari%2C+Ram+C&rft.aulast=Ghosh&rft.aufirst=Kaushik&rft.date=2007-03-01&rft.volume=102&rft.issue=477&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Statistical+Association&rft.issn=01621459&rft_id=info:doi/10.1198%2F016214506000000762 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12228 10919; 12233; 1512 3865 4025; 1939 3617 6220; 8291 3409 6306; 5163; 12759 12228 10919; 7419 8163; 7747 12265 3865 4025 10214 12224 971 12228 10919; 8268 12265 3865 4025 10214 12224 971 12228 10919; 433 293 14 DO - http://dx.doi.org/10.1198/016214506000000762 ER - TY - JOUR T1 - Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease AN - 217846455; 17213842 AB - Although the general association of the inflammatory bowel disease (IBD) 5 region on chromosome 5q31 to Crohn's disease (CD) has been replicated repeatedly, the identity of the precise causal variant within the region remains unknown. A recent report proposed polymorphisms in solute carrier family 22, member 4 (SLC22A4) organic cation transporter 1(OCTN1) and solute carrier family 22, member 5 (SLC22A5) (OCTN2) as responsible for the IBD5 association, but definitive, large-sample comparison of those polymorphisms with others known to be in strong linkage disequilibrium was not performed. We evaluated 1879 affected offspring and parents ascertained by a North American IBD Genetics Consortium for six IBD5 tag single nucleotide polymorphisms (SNPs) to evaluate association localization and ethnic and subphenotypic specificity. We confirm association to the IBD5 region (best SNP IGR2096a_1/rs12521868, P<0.0005) and show this association to be exclusive to the non-Jewish (NJ) population (P=0.00005) (risk allele undertransmitted in Ashkenazi Jews). Using Phase II HapMap data, we demonstrate that there are a set of polymorphisms, spanning genes from prolyl 4-hydroxylase (P4HA2) through interferon regulatory factor 1 (IRF1) with equivalent statistical evidence of association to the reported SLC22A4 variant and that each, by itself, could entirely explain the IBD5 association to CD. Additionally, the previously reported SLC22A5 SNP is rejected as the potential causal variant. No specificity of association was seen with respect to disease type and location, and a modest association to ulcerative colitis is also observed. We confirm the importance of IBD5 to CD susceptibility, demonstrate that the locus may play a role in NJ individuals only, and establish that IRF1, PDLIM, and P4HA2 may be equally as likely to contain the IBD5 causal variant as the OCTN genes. JF - European Journal of Human Genetics : EJHG AU - Silverberg, Mark S AU - Duerr, Richard H AU - Brant, Steven R AU - Bromfield, Gillian AU - Datta, Lisa W AU - Jani, Niraj AU - Kane, Sunanda V AU - Rotter, Jerome I AU - Schumm, L Philip AU - A Hillary Steinhart AU - Taylor, Kent D AU - Yang, Huiying AU - Cho, Judy H AU - Rioux, John D AU - Daly, Mark J Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 328 EP - 35 CY - Leiden PB - Nature Publishing Group VL - 15 IS - 3 SN - 10184813 KW - Medical Sciences KW - Polymorphism, Single Nucleotide KW - Haplotypes KW - Humans KW - Adult KW - Jews -- genetics KW - Male KW - Female KW - Genetic Predisposition to Disease -- ethnology KW - Crohn Disease -- ethnology KW - Chromosomes, Human, Pair 5 -- genetics KW - Crohn Disease -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/217846455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Human+Genetics+%3A+EJHG&rft.atitle=Refined+genomic+localization+and+ethnic+differences+observed+for+the+IBD5+association+with+Crohn%27s+disease&rft.au=Silverberg%2C+Mark+S%3BDuerr%2C+Richard+H%3BBrant%2C+Steven+R%3BBromfield%2C+Gillian%3BDatta%2C+Lisa+W%3BJani%2C+Niraj%3BKane%2C+Sunanda+V%3BRotter%2C+Jerome+I%3BSchumm%2C+L+Philip%3BA+Hillary+Steinhart%3BTaylor%2C+Kent+D%3BYang%2C+Huiying%3BCho%2C+Judy+H%3BRioux%2C+John+D%3BDaly%2C+Mark+J&rft.aulast=Silverberg&rft.aufirst=Mark&rft.date=2007-03-01&rft.volume=15&rft.issue=3&rft.spage=328&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Human+Genetics+%3A+EJHG&rft.issn=10184813&rft_id=info:doi/10.1038%2Fsj.ejhg.5201756 LA - English DB - ProQuest Central N1 - Copyright - Copyright Nature Publishing Group Mar 2007 N1 - Last updated - 2014-04-10 DO - http://dx.doi.org/10.1038/sj.ejhg.5201756 ER - TY - JOUR T1 - Rapid Clearance of Lyme Disease Spirochetes Lacking OspC from Skin AN - 20989378; 7287822 AB - We previously demonstrated that Borrelia burgdorferi requires OspC to colonize a mammalian host. To delineate this requirement, we analyzed the clearance of ospC mutant spirochetes and found that they were eliminated within 48 h. We conclude that B. burgdorferi uses OspC to resist innate host defenses immediately after transmission. JF - Infection and Immunity AU - Tilly, Kit AU - Bestor, Aaron AU - Jewett, Mollie W AU - Rosa, Patricia AD - Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840 Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 1517 EP - 1519 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 3 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Spirochetes KW - Borrelia burgdorferi KW - Lyme disease KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20989378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Rapid+Clearance+of+Lyme+Disease+Spirochetes+Lacking+OspC+from+Skin&rft.au=Tilly%2C+Kit%3BBestor%2C+Aaron%3BJewett%2C+Mollie+W%3BRosa%2C+Patricia&rft.aulast=Tilly&rft.aufirst=Kit&rft.date=2007-03-01&rft.volume=75&rft.issue=3&rft.spage=1517&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Spirochetes; Lyme disease; Borrelia burgdorferi ER - TY - JOUR T1 - Diversity and Distribution of Borrelia hermsii AN - 20928948; 7828882 AB - Borrelia hermsli is the most common cause of tickborne relapsing fever in North America. DNA sequences of the 16S-23S rDNA noncoding intergenic spacer (IGS) region were determined for 37 isolates of this spirochete. These sequences distinguished the 2 genomic groups of B. hermsii identified previously with other loci. Multiple IGS genotypes were identified among isolates from an island, which suggested that birds might play a role in dispersing these spirochetes in nature. In support of this theory, all stages of the tick vector Ornithodoros hermsi fed successfully on birds in the laboratory and advanced in their life cycle. B. hermsii produced a detectable spirochetemia in 1 chicken inoculated subcutaneously. Additional work is warranted to explore the role of birds as enzootic hosts for this relapsing fever spirochete. JF - Emerging Infectious Diseases AU - Schwan, T G AU - Raffel, S J AU - Schrumpf, ME AU - Porcella, S F AD - National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA Y1 - 2007/03// PY - 2007 DA - Mar 2007 VL - 13 IS - 3 SN - 1080-6040, 1080-6040 KW - Entomology Abstracts; Microbiology Abstracts B: Bacteriology KW - Borrelia hermsii KW - Ixodidae KW - Relapsing fever KW - Nucleotide sequence KW - Vectors KW - Life cycle KW - Spacer KW - Genotypes KW - Spirochetes KW - Islands KW - genomics KW - Ornithodoros KW - J 02410:Animal Diseases KW - Z 05360:Genetics and Evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20928948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Emerging+Infectious+Diseases&rft.atitle=Diversity+and+Distribution+of+Borrelia+hermsii&rft.au=Schwan%2C+T+G%3BRaffel%2C+S+J%3BSchrumpf%2C+ME%3BPorcella%2C+S+F&rft.aulast=Schwan&rft.aufirst=T&rft.date=2007-03-01&rft.volume=13&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Emerging+Infectious+Diseases&rft.issn=10806040&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Spirochetes; Islands; Nucleotide sequence; Relapsing fever; Life cycle; Vectors; Spacer; Genotypes; genomics; Borrelia hermsii; Ixodidae; Ornithodoros ER - TY - JOUR T1 - A Comprehensive Investigation of 2-Amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) Metabolism in the Mouse Using a Multivariate Data Analysis Approach AN - 20800102; 7599768 AB - 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a potent rodent carcinogen and a potential human carcinogen because of its existence in the normal human diet. N super(2)-OH-PhIP, a major PhIP metabolite, has been identified as a precursor of genotoxic species. In vitro data supported the view that CYP1A2 is the major enzyme responsible for the formation of N super(2)-OH-PhIP. However, disruption of the CYP1A2 gene in mouse failed to inhibit PhIP-induced carcinogenesis. To investigate the mechanism underlying this observation, the metabolism of PhIP in wild-type, Cyp1a2-null, and CYP1A2-humanized mice was examined in detail using a metabolomic approach. Following data acquisition in a high-resolution LC-MS system, urinary metabolomes of the control and PhIP-treated mice were characterized in a principal component analysis (PCA) model. Comprehensive metabolite profiles of PhIP in high dose (10 mg/kg) and low dose (100 mu g/kg) were established through analyzing urinary ions contributing to the separation of three mouse lines in the multivariate model and by measuring radiolabled PhIP metabolite in a radio-HPLC assay, respectively. The genotoxicity of PhIP to three mouse lines was evaluated by measuring DNA adduction levels in liver, lung, colon, and mammary gland. On the basis of the chemical identities of 17 urinary PhIP metabolites, including eight novel metabolites, multivariate data analysis revealed the role of CYP1A2 in PhIP metabolism and a human-mouse interspecies difference in the catalytic activity of CYP1A2. In addition, the results also showed that Cyp1a2-null mice still possess significant N super(2)-hydroxylation and DNA adduction activities, which may be partially attributed to mouse CYP2C enzymes according to the results from in vitro microsome and Supersome incubations and antibody inhibition experiments. JF - Chemical Research in Toxicology AU - Chen, C AU - Ma, X AU - Malfatti, MA AU - Krausz, K W AU - Kimura, S AU - Felton, J S AU - Idle, J R AU - Gonzalez, F J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 531 EP - 542 VL - 20 IS - 3 SN - 0893-228X, 0893-228X KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Diets KW - Ions KW - DNA adducts KW - Microsomes KW - Data processing KW - CYP1A2 protein KW - Mammary gland KW - Genotoxicity KW - Enzymes KW - Metabolites KW - Carcinogens KW - pyridines KW - Antibodies KW - Colon KW - Lung KW - Principal components analysis KW - Carcinogenesis KW - DNA KW - Liver KW - Cytochrome P450 KW - metabolomics KW - Data acquisition KW - N 14820:DNA Metabolism & Structure KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20800102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Research+in+Toxicology&rft.atitle=A+Comprehensive+Investigation+of+2-Amino-1-methyl-6-phenylimidazo%5B4%2C5-b%5D+pyridine+%28PhIP%29+Metabolism+in+the+Mouse+Using+a+Multivariate+Data+Analysis+Approach&rft.au=Chen%2C+C%3BMa%2C+X%3BMalfatti%2C+MA%3BKrausz%2C+K+W%3BKimura%2C+S%3BFelton%2C+J+S%3BIdle%2C+J+R%3BGonzalez%2C+F+J&rft.aulast=Chen&rft.aufirst=C&rft.date=2007-03-01&rft.volume=20&rft.issue=3&rft.spage=531&rft.isbn=&rft.btitle=&rft.title=Chemical+Research+in+Toxicology&rft.issn=0893228X&rft_id=info:doi/10.1021%2Ftx600320w LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Diets; DNA adducts; Ions; Microsomes; CYP1A2 protein; Data processing; Mammary gland; Genotoxicity; Enzymes; Metabolites; Carcinogens; pyridines; Antibodies; Colon; Lung; Principal components analysis; Carcinogenesis; Liver; DNA; Cytochrome P450; Data acquisition; metabolomics DO - http://dx.doi.org/10.1021/tx600320w ER - TY - JOUR T1 - Differences in Risk Factors for Breast Cancer Molecular Subtypes in a Population-Based Study AN - 20727640; 7314986 AB - Analysis of gene expression data suggests that breast cancers are divisible into molecular subtypes which have distinct clinical features. This study evaluates whether pathologic features and etiologic associations differ among molecular subtypes. We evaluated 804 women with invasive breast cancers and 2,502 controls participating in a Polish Breast Cancer Study. Immunohistochemical stains for estrogen receptor alpha , progesterone receptor, human epidermal growth factor receptors (HER2 and HER1), and cytokeratin 5 were used to classify cases into five molecular subtypes: luminal A, luminal B, HER2-expresing, basal-like, and unclassified. Relative risks were estimated using adjusted odds ratios and 95% confidence intervals. We observed that compared with the predominant luminal A tumors (69%), other subtypes were associated with unfavorable clinical features at diagnosis, especially HER2-expressing (8%) and basal-like (12%) tumors. Increasing body mass index significantly reduced the risk of luminal A tumors among premenopausal women (odds ratios, 0.71; 95% confidence intervals, 0.57-0.88 per five-unit increase), whereas it did not reduce risk for basal-like tumors (1.18; 0.86-1.64; P sub(heterogeneity) = 0.003). On the other hand, reduced risk associated with increasing age at menarche was stronger for basal-like (0.78; 0.68-0.89 per 2-year increase) than luminal A tumors (0.90; 0.95-1.08; P sub(heterogeneity) = 0.0009). Although family history increased risk for all subtypes (except for unclassified tumors), the magnitude of the relative risk was highest for basal-like tumors. Results from this study have shown that breast cancer risk factors may vary by molecular subtypes identified in expression studies, suggesting etiologic, in addition to clinical, heterogeneity of breast cancer. (Cancer Epidemiol Biomarkers Prev 2007; 16(3):439-43) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Yang, Xiaohong R AU - Sherman, Mark E AU - Rimm, David L AU - Lissowska, Jolanta AU - Brinton, Louise A AU - Peplonska, Beata AU - Hewitt, Stephen M AU - Anderson, William F AU - Szeszenia-Dabrowska, Neonila AU - Bardin-Mikolajczak, Alicja AU - Zatonski, Witold AU - Cartun, Richard AU - Mandich, Daniza AU - Rymkiewicz, Grzegorz AU - Ligaj, Marcin AU - Lukaszek, Stanislaw AU - Kordek, Radzisaw AU - Garcia-Closas, Montserrat AD - Division of Cancer Epidemiology and Genetics, Tissue Array Research Program, Laboratory of Pathology, Center For Cancer Research, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 439 EP - 443 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 3 SN - 1055-9965, 1055-9965 KW - Risk Abstracts KW - Bioindicators KW - risk reduction KW - Genetics KW - Age KW - body mass KW - prevention KW - Breast cancer KW - tumors KW - growth factors KW - Cancer KW - estrogens KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20727640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Differences+in+Risk+Factors+for+Breast+Cancer+Molecular+Subtypes+in+a+Population-Based+Study&rft.au=Yang%2C+Xiaohong+R%3BSherman%2C+Mark+E%3BRimm%2C+David+L%3BLissowska%2C+Jolanta%3BBrinton%2C+Louise+A%3BPeplonska%2C+Beata%3BHewitt%2C+Stephen+M%3BAnderson%2C+William+F%3BSzeszenia-Dabrowska%2C+Neonila%3BBardin-Mikolajczak%2C+Alicja%3BZatonski%2C+Witold%3BCartun%2C+Richard%3BMandich%2C+Daniza%3BRymkiewicz%2C+Grzegorz%3BLigaj%2C+Marcin%3BLukaszek%2C+Stanislaw%3BKordek%2C+Radzisaw%3BGarcia-Closas%2C+Montserrat&rft.aulast=Yang&rft.aufirst=Xiaohong&rft.date=2007-03-01&rft.volume=16&rft.issue=3&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Bioindicators; Genetics; risk reduction; Age; body mass; prevention; Breast cancer; tumors; growth factors; Cancer; estrogens ER - TY - JOUR T1 - Towards understanding the mechanism of action of the multidrug resistance-linked half-ABC transporter ABCG2: A molecular modeling study AN - 20720959; 8263300 AB - The ATP-binding cassette protein ABCG2 is a member of a broad family of ABC transporters with potential clinical importance as a mediator of multidrug resistance. We carried out a homology and knowledge-based, and mutationally improved molecular modeling study to establish a much needed structural framework for the protein, which could serve as guidance for further genetic, biochemical, and structural analyses. Based on homology with known structures of both full-length and nucleotide-binding domains (NBD) of ABC transporters and structural knowledge of integral membrane proteins, an initial model of ABCG2 was established. Subsequent refinement to conform to the lipophilic index distributions in the transmembrane domain (TMD) and to the results of site-directed mutagenesis experiments led to an improved model. The complete ABCG2 model consists of two identical subunits facing each other in a closed conformation. The dimeric interface in the nucleotide-binding domain (NBD) involves a characteristic nucleotide sandwich and the interface in the TMD consists of the TM helices 1-3 of one subunit and the helices 5 and 6 of the other. The interface between the NBD and the TMD is bridged by the conserved structural motif between TM2 and TM3, the intracellular domain 1 (ICD1), and the terminal beta -strand (S6) of the central beta -sheet in the NBD. The apparent flexibility of the ICD1 may play a role in transmitting conformational changes from the NBD to the TMD or from the TMD to the NBD. JF - Journal of Molecular Graphics and Modelling AU - Li, Y F AU - Polgar, O AU - Okada, M AU - Esser, L AU - Bates, SE AU - Xia, D AD - Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, United States, dixia@helix.nih.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 837 EP - 851 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 25 IS - 6 SN - 1093-3263, 1093-3263 KW - Biotechnology and Bioengineering Abstracts KW - Site-directed mutagenesis KW - Molecular modelling KW - Homology KW - ABC transporter KW - Multidrug resistance KW - Membrane proteins KW - Transmembrane domains KW - Nucleotides KW - Lipophilic KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20720959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Graphics+and+Modelling&rft.atitle=Towards+understanding+the+mechanism+of+action+of+the+multidrug+resistance-linked+half-ABC+transporter+ABCG2%3A+A+molecular+modeling+study&rft.au=Li%2C+Y+F%3BPolgar%2C+O%3BOkada%2C+M%3BEsser%2C+L%3BBates%2C+SE%3BXia%2C+D&rft.aulast=Li&rft.aufirst=Y&rft.date=2007-03-01&rft.volume=25&rft.issue=6&rft.spage=837&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Graphics+and+Modelling&rft.issn=10933263&rft_id=info:doi/10.1016%2Fj.jmgm.2006.08.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Site-directed mutagenesis; Molecular modelling; Homology; ABC transporter; Multidrug resistance; Membrane proteins; Transmembrane domains; Lipophilic; Nucleotides DO - http://dx.doi.org/10.1016/j.jmgm.2006.08.005 ER - TY - JOUR T1 - Infectious Disease Morbidity Among Young HIV-1-Exposed But Uninfected Infants in Latin American and Caribbean Countries: The National Institute of Child Health and Human Development International Site Development Initiative Perinatal Study AN - 20700222; 7340233 AB - OBJECTIVE. The goal was to describe the frequency, characteristics, and correlates of infectious disease morbidity during the first 6 months of life among HIV-1-exposed but uninfected infants. METHODS. The study population consisted of infants enrolled in the National Institute of Child Health and Human Development International Site Development Initiative Perinatal Study who were HIV-1 uninfected and had follow-up data through the 6-month study visit. Definitive and presumed infections were recorded at study visits (birth, 6-12 weeks, and 6 months). RESULTS. Of 462 HIV-1-uninfected infants with 11644 child-weeks of observation, 283 experienced greater than or equal to 1 infection. These 283 infants experienced 522 infections (1.8 infections per infant). The overall incidence rate of infections was 4.5 cases per 100 child-weeks of observation. Overall, the most common infections were skin or mucous membrane infections (1.9 cases per 100 child-weeks) and respiratory tract infections (1.7 cases per 100 child-weeks). Thirty-six percent of infants had >1 respiratory tract infection (1.8 cases per 100 child-weeks). Incidence rates of upper and lower respiratory tract infections were similar (0.89 cases per 100 child-weeks and 0.9 cases per 100 child-weeks, respectively). Cutaneous and/or oral candidiasis occurred in 48 neonates (10.3%) and 92 older infants (19.3%). Early neonatal sepsis was diagnosed in 12 infants (26.0 cases per 1000 infants). Overall, 81 of 462 (17.5%) infants were hospitalized with an infection. Infants with lower respiratory tract infections were hospitalized frequently (40.7%). The occurrence of greater than or equal to 1 neonatal infection was associated with more-advanced maternal HIV-1 disease, tobacco use during pregnancy, infant anemia, and crowding. Lower maternal CD4 super(+) cell counts, receipt of intrapartum antibiotic treatment, and country of residence were associated with postneonatal infections. CONCLUSIONS. Close monitoring of HIV-1-exposed infants, especially those who are anemic at birth or whose mothers have more-advanced HIV-1 disease or who smoked during pregnancy, remains important. JF - Pediatrics AU - Mussi-Pinhata, Marisa M AU - Freimanis, Laura AU - Yamamoto, Aparecida Y AU - Korelitz, James AU - Pinto, Jorge A AU - Cruz, Maria LS AU - Losso, Marcelo H AU - Read, Jennifer S AD - University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil. Westat, Rockville, Maryland. Federal University of Minas Gerais, Belo Horizonte, Brazil. Hospital dos Servidores do Estado, Rio de Janeiro, Brazil. Hospital General de Agudos Jose Maria Ramos Mejia, Buenos Aires, Argentina. Pediatric, Adolescent, and Maternal AIDS Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, Bethesda, Maryland Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - E694 EP - E704 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 119 IS - 3 SN - 0031-4005, 0031-4005 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Skin KW - Data processing KW - Candidiasis KW - Crowding KW - Anemia KW - Population studies KW - Antibiotics KW - Infection KW - Morbidity KW - Pregnancy KW - Birth KW - Respiratory tract diseases KW - CD4 antigen KW - Sepsis KW - Infectious diseases KW - Human immunodeficiency virus 1 KW - Tobacco KW - Neonates KW - Infants KW - V 22360:AIDS and HIV KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20700222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Infectious+Disease+Morbidity+Among+Young+HIV-1-Exposed+But+Uninfected+Infants+in+Latin+American+and+Caribbean+Countries%3A+The+National+Institute+of+Child+Health+and+Human+Development+International+Site+Development+Initiative+Perinatal+Study&rft.au=Mussi-Pinhata%2C+Marisa+M%3BFreimanis%2C+Laura%3BYamamoto%2C+Aparecida+Y%3BKorelitz%2C+James%3BPinto%2C+Jorge+A%3BCruz%2C+Maria+LS%3BLosso%2C+Marcelo+H%3BRead%2C+Jennifer+S&rft.aulast=Mussi-Pinhata&rft.aufirst=Marisa&rft.date=2007-03-01&rft.volume=119&rft.issue=3&rft.spage=E694&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Skin; Candidiasis; Crowding; Anemia; Population studies; Antibiotics; Infection; Morbidity; Pregnancy; Birth; Respiratory tract diseases; Sepsis; CD4 antigen; Infectious diseases; Tobacco; Neonates; Infants; Human immunodeficiency virus 1 ER - TY - JOUR T1 - Natural Products as Sources of New Drugs over the Last 25 Years AN - 20650250; 7571862 AB - This review is an updated and expanded version of two prior reviews that were published in this journal in 1997 and 2003. In the case of all approved agents the time frame has been extended to include the 25 one half years from 01/1981 to 06/2006 for all diseases worldwide and from 1950 (earliest so far identified) to 06/2006 for all approved antitumor drugs worldwide. We have continued to utilize our secondary subdivision of a "natural product mimic" or "NM" to join the original primary divisions. From the data presented, the utility of natural products as sources of novel structures, but not necessarily the final drug entity, is still alive and well. Thus, in the area of cancer, over the time frame from around the 1940s to date, of the 155 small molecules, 73% are other than "S" (synthetic), with 47% actually being either natural products or directly derived therefrom. In other areas, the influence of natural product structures is quite marked, with, as expected from prior information, the antiinfective area being dependent on natural products and their structures. Although combinatorial chemistry techniques have succeeded as methods of optimizing structures and have, in fact, been used in the optimization of many recently approved agents, we are able to identify only one de novo combinatorial compound approved as a drug in this 25 plus year time frame. We wish to draw the attention of readers to the rapidly evolving recognition that a significant number of natural product drugs/leads are actually produced by microbes and/or microbial interactions with the "host from whence it was isolated", and therefore we consider that this area of natural product research should be expanded significantly. JF - Journal of Natural Products AU - Newman, D J AU - Cragg, G M AD - Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute-Frederick, P.O. Box B, Frederick, Maryland 21702, USA Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 461 EP - 477 VL - 70 IS - 3 SN - 0163-3864, 0163-3864 KW - Biotechnology Research Abstracts (through 1992) KW - Combinatorial chemistry KW - Reviews KW - natural products KW - Drugs KW - Cancer KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20650250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Natural+Products&rft.atitle=Natural+Products+as+Sources+of+New+Drugs+over+the+Last+25+Years&rft.au=Newman%2C+D+J%3BCragg%2C+G+M&rft.aulast=Newman&rft.aufirst=D&rft.date=2007-03-01&rft.volume=70&rft.issue=3&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=Journal+of+Natural+Products&rft.issn=01633864&rft_id=info:doi/10.1021%2Fnp068054v LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - natural products; Drugs; Reviews; Combinatorial chemistry; Cancer DO - http://dx.doi.org/10.1021/np068054v ER - TY - JOUR T1 - Absence of upregulated genes associated with protein accumulations in desmin myopathy AN - 20641281; 9379488 AB - In desmin myopathy but not hereditary inclusion-body myopathy (hIBM), there is accumulation of myofibrillar proteins including desmin, myotilin, dystrophin, gelsolin, actin, and CDC kinase. To assess the cause of protein excess, we studied the genes coding the accumulated proteins in desmin myopathy, hIBM, and controls. No differences were found among them. In desmin myopathy, protein accumulation is not due to upregulation of genes triggered by mutant desmin, but rather to posttranslational disassembly of intermediate filaments. Muscle Nerve, 2006. JF - Muscle & Nerve AU - Raju, Raghavan AU - Dalakas, Marinos C AD - Neuromuscular Diseases Section, National Institute of Neurological Disorders and Stroke, 10 Center Drive, Room 10/4N248, Bethesda, Maryland 20892, USA, dalakasm@ninds.nih.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 386 EP - 388 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 35 IS - 3 SN - 0148-639X, 0148-639X KW - Toxicology Abstracts; Genetics Abstracts KW - Nerves KW - Muscles KW - Gelsolin KW - Dystrophin KW - Actin KW - Intermediate filaments KW - Desmin KW - Myopathy KW - G 07880:Human Genetics KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20641281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Muscle+%26+Nerve&rft.atitle=Absence+of+upregulated+genes+associated+with+protein+accumulations+in+desmin+myopathy&rft.au=Raju%2C+Raghavan%3BDalakas%2C+Marinos+C&rft.aulast=Raju&rft.aufirst=Raghavan&rft.date=2007-03-01&rft.volume=35&rft.issue=3&rft.spage=386&rft.isbn=&rft.btitle=&rft.title=Muscle+%26+Nerve&rft.issn=0148639X&rft_id=info:doi/10.1002%2Fmus.20680 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Nerves; Dystrophin; Gelsolin; Muscles; Actin; Intermediate filaments; Desmin; Myopathy DO - http://dx.doi.org/10.1002/mus.20680 ER - TY - JOUR T1 - Impaired neutrophil activity and increased susceptibility to bacterial infection in mice lacking glucose-6-phosphatase- beta AN - 20617658; 7485621 AB - Neutropenia and neutrophil dysfunction are common in many diseases, although their etiology is often unclear. Previous views held that there was a single ER enzyme, glucose-6-phosphatase- alpha (G6Pase- alpha ), whose activity - limited to the liver, kidney, and intestine - was solely responsible for the final stages of gluconeogenesis and glycogenolysis, in which glucose-6- phosphate (G6P) is hydrolyzed to glucose for release to the blood. Recently, we characterized a second G6Pase activity, that of G6Pase- beta (also known as G6PC), which is also capable of hydrolyzing G6P to glucose but is ubiquitously expressed and not implicated in interprandial blood glucose homeostasis. We now report that the absence of G6Pase- beta led to neutropenia; defects in neutrophil respiratory burst, chemotaxis, and calcium flux; and increased susceptibility to bacterial infection. Consistent with this, G6Pase- beta -deficient (G6pc3 super(-/-)) mice with experimental peritonitis exhibited increased expression of the glucose-regulated proteins upregulated during ER stress in their neutrophils and bone marrow, and the G6pc3 super(-/-) neutrophils exhibited an enhanced rate of apoptosis. Our results define a molecular pathway to neutropenia and neutrophil dysfunction of previously unknown etiology, providing a potential model for the treatment of these conditions. JF - Journal of Clinical Investigation AU - Cheung, Yuk Yin AU - Kim, So Youn AU - Yiu, Wai Han AU - Pan, Chi-Jiunn AU - Jun, Hyun-Sik AU - Ruef, Robert A AU - Lee, Eric J AU - Westphal, Heiner AU - Mansfield, Brian C AU - Chou, Janice Y AD - Section on Cellular Differentiation, Heritable Disorders Branch, National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, Maryland, USA. Department of Biochemistry, The Chinese University of Hong Kong, Hong Kong, People's Republic of China. Laboratory of Mammalian Genes and Development, NICHD, NIH, Bethesda, Maryland, USA. Correlogic Systems Inc., Rockville, Maryland, USA., chouja@mail.nih.gov. Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 784 EP - 793 PB - American Society for Clinical Investigation, 35 Research Drive, Suite 300 Ann Arbor MI 48103 USA, [mailto:asci@the-jci-org], [URL:http://www.asci-jci.org] VL - 117 IS - 3 SN - 0021-9738, 0021-9738 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Bacteria KW - Molecular modelling KW - Etiology KW - Apoptosis KW - Calcium KW - Peritonitis KW - Bone marrow KW - Glucose KW - Leukocytes (neutrophilic) KW - Animal models KW - Stress KW - Enzymes KW - Homeostasis KW - Infection KW - Chemotaxis KW - Blood KW - Neutropenia KW - Respiratory burst KW - Phosphate KW - Gluconeogenesis KW - Kidney KW - Liver KW - Intestine KW - J 02410:Animal Diseases KW - A 01450:Environmental Pollution & Waste Treatment KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20617658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Investigation&rft.atitle=Impaired+neutrophil+activity+and+increased+susceptibility+to+bacterial+infection+in+mice+lacking+glucose-6-phosphatase-+beta&rft.au=Cheung%2C+Yuk+Yin%3BKim%2C+So+Youn%3BYiu%2C+Wai+Han%3BPan%2C+Chi-Jiunn%3BJun%2C+Hyun-Sik%3BRuef%2C+Robert+A%3BLee%2C+Eric+J%3BWestphal%2C+Heiner%3BMansfield%2C+Brian+C%3BChou%2C+Janice+Y&rft.aulast=Cheung&rft.aufirst=Yuk&rft.date=2007-03-01&rft.volume=117&rft.issue=3&rft.spage=784&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Investigation&rft.issn=00219738&rft_id=info:doi/10.1172%2FJCI30443 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Etiology; Calcium; Apoptosis; Peritonitis; Animal models; Leukocytes (neutrophilic); Glucose; Bone marrow; Enzymes; Stress; Homeostasis; Infection; Chemotaxis; Neutropenia; Blood; Respiratory burst; Phosphate; Gluconeogenesis; Intestine; Liver; Kidney; Bacteria DO - http://dx.doi.org/10.1172/JCI30443 ER - TY - JOUR T1 - Effect of tobacco deprivation on the attentional blink in rapid serial visual presentation AN - 20475317; 7961384 AB - When two targets are imbedded in rapid serial visual presentation (RSVP), identification of the second target (T2) is impaired if it occurs within 500ms of the first target (T1). This attentional blink (AB) is thought to involve interference of resources in processing T1 and T2. The deleterious effect of tobacco deprivation on attention has been documented, but no studies have examined the AB. Nonsmokers (n=30), 12-h tobacco-deprived smokers (n=30), and nondeprived smokers (n=30) were randomly assigned to perform the RSVP with one of three stimulus-duration conditions (96, 113, or 130ms). Participants completed 48 RSVP trials. Each trial consisted of 16 individually presented words (T1, T2, and 14 distractors), and T2 lagged T1 at serial positions 1-8. Participants verbalized T1 and T2 in order immediately after each trial. Identification of T2 (for correct T1 trials) was impaired at early versus late lag positions, which was especially pronounced in the most difficult (96ms) condition. There was no evidence for group differences on the AB; however, deprived smokers were worse identifying T1 in the 113-ms condition. These results suggest that the AB is influenced by stimulus duration, but not by 12h of tobacco deprivation. JF - Human Psychopharmacology: Clinical and Experimental AU - Heinz, Adrienne AU - Waters, Andrew J AU - Taylor, Richard C AU - Myers, Carol S AU - Moolchan, Eric T AU - Heishman, Stephen J AD - Clinical Pharmacology and Therapeutics Branch, National Institute on Drug Abuse, NIH, Baltimore, Maryland, USA, heishman@nih.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 89 EP - 96 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 22 IS - 2 SN - 0885-6222, 0885-6222 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Antibodies KW - Tobacco KW - Clinical trials KW - Attention KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20475317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Psychopharmacology%3A+Clinical+and+Experimental&rft.atitle=Effect+of+tobacco+deprivation+on+the+attentional+blink+in+rapid+serial+visual+presentation&rft.au=Heinz%2C+Adrienne%3BWaters%2C+Andrew+J%3BTaylor%2C+Richard+C%3BMyers%2C+Carol+S%3BMoolchan%2C+Eric+T%3BHeishman%2C+Stephen+J&rft.aulast=Heinz&rft.aufirst=Adrienne&rft.date=2007-03-01&rft.volume=22&rft.issue=2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Human+Psychopharmacology%3A+Clinical+and+Experimental&rft.issn=08856222&rft_id=info:doi/10.1002%2Fhup.826 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Antibodies; Tobacco; Attention; Clinical trials DO - http://dx.doi.org/10.1002/hup.826 ER - TY - JOUR T1 - Truncated tyrosine kinase B brain-derived neurotrophic factor receptor directs cortical neural stem cells to a glial cell fate by a novel signaling mechanism AN - 20464814; 9147957 AB - AbstractDuring development of the mammalian cerebral cortex neural stem cells (NSC) first generate neurons and subsequently produce glial cells. The mechanism(s) responsible for this developmental shift from neurogenesis to gliogenesis is unknown. Brain-derived neurotrophic factor (BDNF) is believed to play important roles in the development of the mammalian cerebral cortex; it enhances neurogenesis and promotes the differentiation and survival of newly generated neurons. Here, we provide evidence that a truncated form of the BDNF receptor tyrosine kinase B (trkB-t) plays a pivotal role in directing embryonic mouse cortical NSC to a glial cell fate. Expression of trkB-t promotes differentiation of NSC toward astrocytes while inhibiting neurogenesis both in cell culture and in vivo. The mechanism by which trkB-t induces astrocyte genesis is not simply the result of inhibition of full-length receptor with intrinsic tyrosine kinase activity signaling. Instead, binding of BDNF to trkB-t activates a signaling pathway (involving a G-protein and protein kinase C) that induced NSC to become glial progenitors and astrocytes. Thus, the increased expression of trkB-t in the embryonic cerebral cortex that occurs coincident with astrocyte production plays a pivotal role in the developmental transition from neurogenesis to gliogenesis. Our findings suggest a mechanism by which a single factor (BDNF) regulates the production of the two major cell types in the mammalian cerebral cortex. JF - Journal of Neurochemistry AU - Cheng, Aiwu AU - Coksaygan, Turhan AU - Tang, Hongyan AU - Khatri, Rina AU - Balice-Gordon, Rita J AU - Rao, Mahendra S AU - Mattson, Mark P AD - *Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA, chengai@grc.nia.nih.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 1515 EP - 1530 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 100 IS - 6 SN - 0022-3042, 0022-3042 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - brain-derived neurotrophic factor KW - truncated form of tyrosine kinase B1 KW - neural stem cells KW - neurogenesis KW - glial progenitor cells KW - neural development KW - neural differentiation KW - protein kinase C KW - Cell survival KW - Brain-derived neurotrophic factor KW - Protein kinase C KW - Astrocytes KW - Glial cells KW - Guanine nucleotide-binding protein KW - Cell culture KW - Protein-tyrosine kinase receptors KW - Differentiation KW - Neurogenesis KW - Glial stem cells KW - Cortex KW - Protein-tyrosine kinase KW - Embryos KW - Neural stem cells KW - Gliogenesis KW - Signal transduction KW - Brain-derived neurotrophic factor receptors KW - N3 11008:Neurochemistry KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20464814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurochemistry&rft.atitle=Truncated+tyrosine+kinase+B+brain-derived+neurotrophic+factor+receptor+directs+cortical+neural+stem+cells+to+a+glial+cell+fate+by+a+novel+signaling+mechanism&rft.au=Cheng%2C+Aiwu%3BCoksaygan%2C+Turhan%3BTang%2C+Hongyan%3BKhatri%2C+Rina%3BBalice-Gordon%2C+Rita+J%3BRao%2C+Mahendra+S%3BMattson%2C+Mark+P&rft.aulast=Cheng&rft.aufirst=Aiwu&rft.date=2007-03-01&rft.volume=100&rft.issue=6&rft.spage=1515&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurochemistry&rft.issn=00223042&rft_id=info:doi/10.1111%2Fj.1471-4159.2006.04337.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Protein kinase C; Brain-derived neurotrophic factor; Cell survival; Astrocytes; Glial cells; Guanine nucleotide-binding protein; Protein-tyrosine kinase receptors; Cell culture; Differentiation; Neurogenesis; Cortex; Glial stem cells; Protein-tyrosine kinase; Embryos; Neural stem cells; Gliogenesis; Brain-derived neurotrophic factor receptors; Signal transduction DO - http://dx.doi.org/10.1111/j.1471-4159.2006.04337.x ER - TY - JOUR T1 - Isolation and characterization of microsatellite markers in pangolins (Mammalia, Pholidota, Manis spp.) AN - 20461028; 9149893 AB - AbstractThirty-four polymorphic dinucleotide microsatellite loci were developed in the Malayan pangolin Manis javanica. Of the 34 markers, 32 and 18 were also amplified, respectively, in the Chinese pangolin (Manis pentadactyla) and the African tree pangolin (Manis tricuspis). Analysis of 24 Malayan, 12 Chinese and 2 African tree pangolins showed high levels of variability (heterozygosity ranging from 0.321 to 0.708). These are the first available microsatellite markers in Pholidota and will be an invaluable tool for evolutionary and conservation genetic studies in pangolins. JF - Molecular Ecology Notes AU - Luo, Shu-Jin AU - Cai, Qing-Xiu AU - David, Victor A AU - Zhang, Li AU - Martelli, Paolo AU - Lim, Norman T-L AU - Ferrand, Nuno AU - Chin, Shih-Chien AU - Gaubert, Philippe AU - Ramos, Maria Joao AU - O'Brien, Stephen J AU - Antunes, Agostinho AU - Johnson, Warren E AD - *Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702-1201, USA,, aantunes@ncifcrf.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 269 EP - 272 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 7 IS - 2 SN - 1471-8278, 1471-8278 KW - Ecology Abstracts; Genetics Abstracts; Sustainability Science Abstracts KW - Manis KW - microsatellite KW - pangolin KW - Pholidota KW - conservation genetics KW - Trees KW - Genetic markers KW - Mammalia KW - Microsatellites KW - Africa KW - Heterozygosity KW - Conservation genetics KW - Evolution KW - M3 1010:Issues in Sustainable Development KW - G 07750:Ecological & Population Genetics KW - D 04060:Management and Conservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20461028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Ecology+Notes&rft.atitle=Isolation+and+characterization+of+microsatellite+markers+in+pangolins+%28Mammalia%2C+Pholidota%2C+Manis+spp.%29&rft.au=Luo%2C+Shu-Jin%3BCai%2C+Qing-Xiu%3BDavid%2C+Victor+A%3BZhang%2C+Li%3BMartelli%2C+Paolo%3BLim%2C+Norman+T-L%3BFerrand%2C+Nuno%3BChin%2C+Shih-Chien%3BGaubert%2C+Philippe%3BRamos%2C+Maria+Joao%3BO%27Brien%2C+Stephen+J%3BAntunes%2C+Agostinho%3BJohnson%2C+Warren+E&rft.aulast=Luo&rft.aufirst=Shu-Jin&rft.date=2007-03-01&rft.volume=7&rft.issue=2&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=Molecular+Ecology+Notes&rft.issn=14718278&rft_id=info:doi/10.1111%2Fj.1471-8286.2006.01577.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Trees; Genetic markers; Microsatellites; Conservation genetics; Heterozygosity; Evolution; conservation genetics; Mammalia; Pholidota; Africa DO - http://dx.doi.org/10.1111/j.1471-8286.2006.01577.x ER - TY - JOUR T1 - Challenges and Solutions in Proteomics AN - 20424300; 7731262 AB - The accelerated growth of proteomics data presents both opportunities and challenges. Large-scale proteomic profiling of biological samples such as cells, organelles or biological fluids has led to discovery of numerous key and novel proteins involved in many biological/disease processes including cancers, as well as to the identification of novel disease biomarkers and potential therapeutic targets. While proteomic data analysis has been greatly assisted by the many bioinformatics tools developed in recent years, a careful analysis of the major steps and flow of data in a typical highthroughput analysis reveals a few gaps that still need to be filled to fully realize the value of the data. To facilitate functional and pathway discovery for large-scale proteomic data, we have developed an integrated proteomic expression analysis system, iProXpress, which facilitates protein identification using a comprehensive sequence library and functional interpretation using integrated data. With its modular design, iProXpress complements and can be integrated with other software in a proteomic data analysis pipeline. This novel approach to complex biological questions involves the interrogation of multiple data sources, thereby facilitating hypothesis generation and knowledge discovery from the genomic-scale studies and fostering disease diagnosis and drug development. JF - Current Genomics AU - Huang, H AU - Shukla, H D AU - Wu, C AU - Saxena, S AD - Proteomics and Mass Spectrometry Unit, Research Resources Branch, National Institute on Aging, National Institutes of Health, 333 Cassell Dr., Baltimore, MD 21224, USA Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 21 EP - 28 VL - 8 IS - 1 SN - 1389-2029, 1389-2029 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Computer programs KW - software KW - Data processing KW - Drug development KW - proteomics KW - Bioinformatics KW - Organelles KW - biomarkers KW - Cancer KW - W 30960:Bioinformatics & Computer Applications KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20424300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Genomics&rft.atitle=Challenges+and+Solutions+in+Proteomics&rft.au=Huang%2C+H%3BShukla%2C+H+D%3BWu%2C+C%3BSaxena%2C+S&rft.aulast=Huang&rft.aufirst=H&rft.date=2007-03-01&rft.volume=8&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Current+Genomics&rft.issn=13892029&rft_id=info:doi/10.2174%2F138920207780076910 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Computer programs; software; Data processing; Drug development; Bioinformatics; proteomics; Organelles; biomarkers; Cancer DO - http://dx.doi.org/10.2174/138920207780076910 ER - TY - JOUR T1 - Proteomic expression profiling of thyroid neoplasms AN - 20413151; 7732025 AB - Thyroid cancer is the most common endocrine neoplasm with multiple histologic subtypes, each associated with different treatments and outcomes. Differentiating benign neoplasms such as follicular adenomas from malignant entities such as follicular carcinomas and papillary carcinoma can be challenging. To define the proteomic profile of different thyroid tumors, we screened an antibody array of 330 features against five thyroid neoplasms: follicular adenoma, follicular carcinoma, papillary carcinoma, anaplastic carcinoma, and medullary carcinoma as well as normal thyroid epithelium. Eight candidate biomarkers; c-erbB-2, Stat5a, Annexin IV, IL-11, RAR alpha , FGF7, Caspase 9, and phospho-c-myc were identified as differentially expressed on the antibody array, and validated with immunohistochemistry on tissue microarrays, with a total of 144 samples of the same variety of thyroid neoplasms. Analysis revealed c-erbB-2, Annexin IV, and Stat5a have potential clinical utility to differentiate follicular adenoma, follicular carcinoma, and papillary carcinoma from each other. By using an antibody array as a discovery platform and a tissue microarray as a first step in validation on a large number of specimens, we have identified new markers that have potential utility in the diagnosis of thyroid neoplasms. JF - Proteomics Clinical Applications AU - Braunschweig, T AU - Kaserer, K AU - Chung, J-Y AU - Bilke, S AU - Krizman, D AU - Knezevic, V AU - Hewitt, S M AD - TARP Laboratory, Advanced Technology Center, MSC 4605, Bethesda, MD 20892-4605, USA, genejock@helix.nih.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 264 EP - 271 VL - 1 IS - 3 SN - 1862-8346, 1862-8346 KW - Biotechnology Research Abstracts (through 1992) KW - Caspase-9 KW - Fibroblast growth factor receptor 7 KW - Tumors KW - biomarkers KW - Carcinoma KW - Interleukin 11 KW - Antibodies KW - thyroid cancer KW - Epithelium KW - proteomics KW - Immunohistochemistry KW - Adenoma KW - Annexin IV KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20413151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics+Clinical+Applications&rft.atitle=Proteomic+expression+profiling+of+thyroid+neoplasms&rft.au=Braunschweig%2C+T%3BKaserer%2C+K%3BChung%2C+J-Y%3BBilke%2C+S%3BKrizman%2C+D%3BKnezevic%2C+V%3BHewitt%2C+S+M&rft.aulast=Braunschweig&rft.aufirst=T&rft.date=2007-03-01&rft.volume=1&rft.issue=3&rft.spage=264&rft.isbn=&rft.btitle=&rft.title=Proteomics+Clinical+Applications&rft.issn=18628346&rft_id=info:doi/10.1002%2Fprca.200600381 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Carcinoma; Antibodies; Adenoma; proteomics; Annexin IV; thyroid cancer; Interleukin 11; biomarkers; Epithelium; Immunohistochemistry; Fibroblast growth factor receptor 7; Tumors; Caspase-9 DO - http://dx.doi.org/10.1002/prca.200600381 ER - TY - JOUR T1 - Novel adenovirus vaccine vectors based on the enteric-tropic serotype 41 AN - 20357792; 7640469 AB - Replication-defective adenovirus vectors, primarily developed from serotype 5 (Ad5) viruses, have been widely used for gene transfer and vaccination approaches. Vectors based on other serotypes of adenovirus could be used in conjunction with, or in place of, Ad5 vectors. In this study, Ad41, an enteric adenovirus usually described as 'non-cultivable' or 'fastidious,' has been successfully cloned, rescued and propagated on 293-ORF6 cells. The complementation capabilities of this cell line allow generation of Ad41 vectors at titers comparable to those obtained for Ad5 vectors. Mice immunized with an Ad41 vector containing an HIV envelope (Env) gene mounted anti-Env cellular and humoral immune responses. Ad41-Env vectors appear to be particularly attractive when used in heterologous prime-boost regimens, where they induce significantly higher cellular immune responses to HIV-Env than Ad5-based regimens. Ad41-based constructs are attractive vaccine vectors alone or in combination with Ad5 adenovectors, since each vector type can provide circumvention of pre-existing immunity to the other. JF - Vaccine AU - Lemiale, Franck AU - Haddada, Hedi AU - Nabel, Gary J AU - Brough, Douglas E AU - King, C Richter AU - Gall, Jason G D AD - Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD 20892, United States, jgall@genvec.com Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 2074 EP - 2084 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 25 IS - 11 SN - 0264-410X, 0264-410X KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Serotypes KW - Env protein KW - Expression vectors KW - Envelopes KW - Complementation KW - Adenovirus KW - Immunity KW - Vaccination KW - Gene transfer KW - Human immunodeficiency virus KW - Vaccines KW - V 22350:Immunology KW - F 06905:Vaccines KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20357792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Novel+adenovirus+vaccine+vectors+based+on+the+enteric-tropic+serotype+41&rft.au=Lemiale%2C+Franck%3BHaddada%2C+Hedi%3BNabel%2C+Gary+J%3BBrough%2C+Douglas+E%3BKing%2C+C+Richter%3BGall%2C+Jason+G+D&rft.aulast=Lemiale&rft.aufirst=Franck&rft.date=2007-03-01&rft.volume=25&rft.issue=11&rft.spage=2074&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2006.11.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Adenovirus; Human immunodeficiency virus; Expression vectors; Serotypes; Vaccines; Env protein; Gene transfer; Complementation; Immunity; Vaccination; Envelopes DO - http://dx.doi.org/10.1016/j.vaccine.2006.11.025 ER - TY - JOUR T1 - Complement levels and activity in the normal and LPS-injured lung AN - 20325218; 7314049 AB - Complement, a complex protein system, plays an essential role in host defense through bacterial lysis, stimulation of phagocytosis, recruitment of immune cells to infected tissue, and promotion of the inflammatory response. Although complement is most well-characterized in serum, complement activity is also present in the lung. Here we further characterize the complement system in the normal and inflamed lung. By Western blot, C5, C6, and factor I were detected in bronchoalveolar lavage (BAL) at lower levels than in serum, whereas C2 was detected at similar levels in BAL and serum. C4 binding protein (C4BP) was not detectable in BAL. Exposure to lipopolysaccharide (LPS) elevated levels of C1q, factor B, C2, C4, C5, C6, and C3 in human BAL and C3, C5, and factor B in mouse and rat BAL. Message for C1q-B, C1r, C1s, C2, C4, C3, C5, C6, factor B, and factor H, but not C9 or C4BP, was readily detectable by RT-PCR in normal mouse lung. Exposure to LPS enhanced factor B expression, decreased C5 expression, and did not affect C1q-B expression in mouse and rat lung. BAL from rats exposed to LPS had a greater ability to deposit C3b onto bacteria through complement activation than did BAL from control rats. In summary, these data demonstrate that complement levels, expression, and function are altered in acute lung injury and suggest that complement within the lung is regulated to promote opsonization of pathogens and limit potentially harmful inflammation. JF - American Journal of Physiology: Lung Cellular and Molecular Physiology AU - Bolger, Molly S AU - Ross, DeAndre S AU - Jiang, Haixiang AU - Frank, Michael M AU - Ghio, Andrew J AU - Schwartz, David A AU - Wright, Jo Rae AD - Departments of Cell Biology and Pediatrics, Duke University Medical Center, Durham, Human Studies Division, Environmental Protection Agency, Chapel Hill, and the National Institute of Environmental Health Sciences and National Toxicology Program, Durham, North Carolina Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - L748 EP - L759 PB - American Physiological Society, 9650 Rockville Pike Bethesda MD 20814-3991 USA, [mailto:webmaster@the-aps.org], [URL:http://www.the-aps.org/] VL - 292 IS - 3 SN - 1040-0605, 1040-0605 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Deposits KW - Western blotting KW - Data processing KW - Injuries KW - Complement component C1q KW - Complement factor H KW - complement component C4 KW - Pathogens KW - Alveoli KW - Inflammation KW - Bronchus KW - Complement component C3b KW - Lung KW - Complement activation KW - Polymerase chain reaction KW - Lipopolysaccharides KW - Complement component C3 KW - Phagocytosis KW - Opsonization KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20325218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Physiology%3A+Lung+Cellular+and+Molecular+Physiology&rft.atitle=Complement+levels+and+activity+in+the+normal+and+LPS-injured+lung&rft.au=Bolger%2C+Molly+S%3BRoss%2C+DeAndre+S%3BJiang%2C+Haixiang%3BFrank%2C+Michael+M%3BGhio%2C+Andrew+J%3BSchwartz%2C+David+A%3BWright%2C+Jo+Rae&rft.aulast=Bolger&rft.aufirst=Molly&rft.date=2007-03-01&rft.volume=292&rft.issue=3&rft.spage=L748&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Physiology%3A+Lung+Cellular+and+Molecular+Physiology&rft.issn=10400605&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Western blotting; Deposits; Data processing; Injuries; Complement component C1q; Complement factor H; Pathogens; complement component C4; Alveoli; Inflammation; Complement component C3b; Bronchus; Lung; Complement activation; Lipopolysaccharides; Polymerase chain reaction; Complement component C3; Phagocytosis; Opsonization ER - TY - JOUR T1 - Investigating subsumption in SNOMED CT: An exploration into large description logic-based biomedical terminologies AN - 20267550; 7497172 AB - Objective: Formalisms based on one or other flavor of description logic (DL) are sometimes put forward as helping to ensure that terminologies and controlled vocabularies comply with sound ontological principles. The objective of this paper is to study the degree to which one DL-based biomedical terminology (SNOMED CT) does indeed comply with such principles. Materials and methods: We defined seven ontological principles (for example: each class must have at least one parent, each class must differ from its parent) and examined the properties of SNOMED CT classes with respect to these principles. Results: Our major results are 31% of these classes have a single child; 27% have multiple parents; 51% do not exhibit any differentiae between the description of the parent and that of the child. Conclusions: The applications of this principles to quality assurance for ontologies are discussed and suggestions are made for dealing with the phenomenon of multiple inheritance. The advantages and limitations of our approach are also discussed. JF - Artificial Intelligence in Medicine AU - Bodenreider, O AU - Smith, B AU - Kumar, A AU - Burgun, A AD - National Institutes of Health, Bethesda, MD, USA, olivier@nlm.nih.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 183 EP - 195 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 39 IS - 3 SN - 0933-3657, 0933-3657 KW - Biotechnology and Bioengineering Abstracts KW - Computed tomography KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20267550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Artificial+Intelligence+in+Medicine&rft.atitle=Investigating+subsumption+in+SNOMED+CT%3A+An+exploration+into+large+description+logic-based+biomedical+terminologies&rft.au=Bodenreider%2C+O%3BSmith%2C+B%3BKumar%2C+A%3BBurgun%2C+A&rft.aulast=Bodenreider&rft.aufirst=O&rft.date=2007-03-01&rft.volume=39&rft.issue=3&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Artificial+Intelligence+in+Medicine&rft.issn=09333657&rft_id=info:doi/10.1016%2Fj.artmed.2006.12.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Computed tomography DO - http://dx.doi.org/10.1016/j.artmed.2006.12.003 ER - TY - JOUR T1 - Inducible and Reversible Transgene Expression in Human Stem Cells After Efficient and Stable Gene Transfer AN - 20243265; 7340709 AB - We report here a lentiviral vector system for regulated transgene expression. We used the tetracycline repressor fused with a transcriptional suppression domain (tTS) to specifically suppress transgene expression. Human cells were first transduced with a tTS-expressing vector and subsequently transduced with a second lentiviral vector-containing transgene controlled by a regular promoter adjacent to a high-affinity tTS-binding site (tetO). After optimizing the location of the tetO site in the latter vector, we achieved a better inducible transgene expression than the previous lentiviral vectors using the tetracycline repressor systems. In this new system, the transgene transcription from a cellular promoter such as EF1 alpha or ubiquitin-C promoter is suppressed by the tTS bound to the nearby tetO site. In the presence of the tetracycline analog doxycycline (Dox), however, the tTS binding is released from the transgene vector and transcription from the promoter is restored. Thus, this system simply adds an extra level of regulation, suitable for any types of promoters (ubiquitous or cell-specific). We tested this tTS-suppressive, Dox-inducible system in 293T cells, human multipotent hematopoietic progenitor cells, and three human embryonic stem cell lines, using a dual-gene vector containing the green fluorescent protein reporter or a cellular gene. We observed a tight suppression in the uninduced state. However, the suppression is reversible, and transgene expression was restored at 5 ng/ml Dox. The lentiviral vectors containing the tTS-suppressive, Dox-inducible system offer a universal, inducible, and reversible transgene expression system in essentially any mammalian cell types, including human embryonic stem cells. JF - Stem Cells AU - Zhou, Betty Ying AU - Ye, Zhaohui AU - Chen, Guibin AU - Gao, Zhigang Peter AU - Zhang, Yu A AU - Cheng, Linzhao AD - Stem Cell Program, Institute for Cell Engineering and Department of Gynecology and Obstetrics, Graduate Program in Immunology, and Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. Neuro-Oncology Branch, National Cancer Institute/National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA. Xuanwu Hospital, the Capital University of Medical Sciences, Beijing, China Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 779 EP - 789 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 25 IS - 3 SN - 1066-5099, 1066-5099 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Transgenes KW - Green fluorescent protein KW - Transcription KW - Tetracyclines KW - Expression vectors KW - Promoters KW - Stem cells KW - Mammalian cells KW - Embryo cells KW - Gene transfer KW - Hemopoiesis KW - Repressors KW - Doxycycline KW - W 30925:Genetic Engineering KW - G 07870:Mammals KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20243265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Inducible+and+Reversible+Transgene+Expression+in+Human+Stem+Cells+After+Efficient+and+Stable+Gene+Transfer&rft.au=Zhou%2C+Betty+Ying%3BYe%2C+Zhaohui%3BChen%2C+Guibin%3BGao%2C+Zhigang+Peter%3BZhang%2C+Yu+A%3BCheng%2C+Linzhao&rft.aulast=Zhou&rft.aufirst=Betty&rft.date=2007-03-01&rft.volume=25&rft.issue=3&rft.spage=779&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Transgenes; Green fluorescent protein; Transcription; Tetracyclines; Expression vectors; Promoters; Stem cells; Embryo cells; Mammalian cells; Gene transfer; Hemopoiesis; Repressors; Doxycycline ER - TY - JOUR T1 - Extrathymic Generation of Tumor-Specific T Cells from Genetically Engineered Human Hematopoietic Stem Cells via Notch Signaling AN - 20226231; 7314859 AB - Adoptive cell transfer (ACT) of tumor-reactive lymphocytes has been shown to be an effective treatment for cancer patients. Studies in murine models of ACT indicated that antitumor efficacy of adoptively transferred T cells is dependent on the differentiation status of the cells, with lymphocyte differentiation inversely correlated with in vivo antitumor effectiveness. T-cell in vitro development technologies provide a new opportunity to generate naive T cells for the purpose of ACT. In this study, we genetically modified human umbilical cord blood-derived hematopoietic stem cells (HSCs) to express tumor antigen-specific T-cell receptor (TCR) genes and generated T lymphocytes by coculture with a murine cell line expressing Notch-1 ligand, Delta-like-1 (OP9-DL1). Input HSCs were differentiated into T cells as evidenced by the expression of T-cell markers, such as CD7, CD1a, CD4, CD8, and CD3, and by detection of TCR excision circles. We found that such in vitro differentiated T cells expressed the TCR and showed HLA-A2-restricted, specific recognition and killing of tumor antigen peptide-pulsed antigen-presenting cells but manifested additional natural killer cell-like killing of tumor cell lines. The genetic manipulation of HSCs has broad implications for ACT of cancer. [Cancer Res 2007; 67(6):2425-9] JF - Cancer Research AU - Zhao, Yangbing AU - Parkhurst, Maria R AU - Zheng, Zhili AU - Cohen, Cyrille J AU - Riley, John P AU - Gattinoni, Luca AU - Restifo, Nicholas P AU - Rosenberg, Steven A AU - Morgan, Richard A AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 2425 EP - 2429 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 67 IS - 6 SN - 0008-5472, 0008-5472 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Histocompatibility antigen HLA KW - T-cell receptor KW - double prime T-cell receptor KW - Natural killer cells KW - Animal models KW - Tumors KW - CD8 antigen KW - Umbilical cord KW - Cancer KW - Notch protein KW - Differentiation KW - Blood KW - Tumor cell lines KW - CD4 antigen KW - Stem cells KW - CD7 antigen KW - Genetic engineering KW - Antigen (tumor-associated) KW - Lymphocytes T KW - Antigen-presenting cells KW - CD3 antigen KW - Antitumor activity KW - Signal transduction KW - W 30925:Genetic Engineering KW - F 06915:Cancer Immunology KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20226231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Extrathymic+Generation+of+Tumor-Specific+T+Cells+from+Genetically+Engineered+Human+Hematopoietic+Stem+Cells+via+Notch+Signaling&rft.au=Zhao%2C+Yangbing%3BParkhurst%2C+Maria+R%3BZheng%2C+Zhili%3BCohen%2C+Cyrille+J%3BRiley%2C+John+P%3BGattinoni%2C+Luca%3BRestifo%2C+Nicholas+P%3BRosenberg%2C+Steven+A%3BMorgan%2C+Richard+A&rft.aulast=Zhao&rft.aufirst=Yangbing&rft.date=2007-03-01&rft.volume=67&rft.issue=6&rft.spage=2425&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; T-cell receptor; double prime T-cell receptor; Animal models; Natural killer cells; CD8 antigen; Tumors; Cancer; Umbilical cord; Notch protein; Blood; Differentiation; CD7 antigen; Stem cells; CD4 antigen; Tumor cell lines; Genetic engineering; Antigen (tumor-associated); Lymphocytes T; CD3 antigen; Antigen-presenting cells; Signal transduction; Antitumor activity ER - TY - JOUR T1 - Smad4 is critical for self-renewal of hematopoietic stem cells AN - 19990152; 7316575 AB - Members of the transforming growth factor {szligbeta} (TGF-{szligbeta}) superfamily of growth factors have been shown to regulate the in vitro proliferation and maintenance of hematopoietic stem cells (HSCs). Working at a common level of convergence for all TGF-{szligbeta} superfamily signals, Smad4 is key in orchestrating these effects. The role of Smad4 in HSC function has remained elusive because of the early embryonic lethality of the conventional knockout. We clarify its role by using an inducible model of Smad4 deletion coupled with transplantation experiments. Remarkably, systemic induction of Smad4 deletion through activation of MxCre was incompatible with survival 4 wk after induction because of anemia and histopathological changes in the colonic mucosa. Isolation of Smad4 deletion to the hematopoietic system via several transplantation approaches demonstrated a role for Smad4 in the maintenance of HSC self-renewal and reconstituting capacity, leaving homing potential, viability, and differentiation intact. Furthermore, the observed down-regulation of notch1 and c-myc in Smad4 super(-/-) primitive cells places Smad4 within a network of genes involved in the regulation HSC renewal. JF - Journal of Experimental Medicine AU - Karlsson, Goeran AU - Blank, Ulrika AU - Moody, Jennifer L AU - Ehinger, Mats AU - Singbrant, Sofie AU - Deng, Chu-Xia AU - Karlsson, Stefan AD - Department of Molecular Medicine and Gene Therapy, Institute of Laboratory Medicine, Lund University Hospital and Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, 22184 Lund, Sweden. Department of Pathology, Helsingborgs Lasarett, 251 87 Helsingborg, Sweden. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892 Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 467 EP - 474 PB - Rockefeller University Press, 1114 First Avenue New York NY 10021-8325 USA, [mailto:Bruce.Lyons@rockefeller.edu], [URL:http://www.rockefeller.edu/rupress] VL - 204 IS - 3 SN - 0022-1007, 0022-1007 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Transforming growth factor KW - Homing behavior KW - Mucosa KW - Anemia KW - Survival KW - Smad4 protein KW - Differentiation KW - Stem cells KW - Lethality KW - Convergence KW - Hemopoiesis KW - Embryos KW - Cell migration KW - Cell proliferation KW - c-Myc protein KW - W 30925:Genetic Engineering KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19990152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Medicine&rft.atitle=Smad4+is+critical+for+self-renewal+of+hematopoietic+stem+cells&rft.au=Karlsson%2C+Goeran%3BBlank%2C+Ulrika%3BMoody%2C+Jennifer+L%3BEhinger%2C+Mats%3BSingbrant%2C+Sofie%3BDeng%2C+Chu-Xia%3BKarlsson%2C+Stefan&rft.aulast=Karlsson&rft.aufirst=Goeran&rft.date=2007-03-01&rft.volume=204&rft.issue=3&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Medicine&rft.issn=00221007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Transforming growth factor; Homing behavior; Mucosa; Anemia; Survival; Smad4 protein; Differentiation; Stem cells; Lethality; Convergence; Hemopoiesis; Embryos; Cell migration; Cell proliferation; c-Myc protein ER - TY - JOUR T1 - Concentration-Dependent Effects of Caspofungin on the Metabolic Activity of Aspergillus Species AN - 19986510; 7285349 AB - The minimum effective concentration (MEC) used to assess the in vitro antifungal activity of caspofungin against Aspergillus spp. is a qualitative endpoint requiring microscopic examination of hyphae. We therefore developed a tool for the quantitative assessment of caspofungin activity against Aspergillus spp. at clinically applicable concentrations. Susceptibility to caspofungin (0.008 to 8 mu g/ml) was studied for 9 A. fumigatus, 8 A. flavus, and 12 A. terreus isolates based on the Clinical and Laboratory Standards Institute M38-A protocol. After 48 h of incubation, the MEC was defined microscopically, and metabolic activity assessed with a modified XTT assay, using 100 mu g of the tetrazolium salt XTT/ml and 6.25 mu M menadione. A significant reduction in metabolic activity was demonstrated at the MEC (0.25 to 0.5 mu g/ml) for all Aspergillus spp. and was more pronounced for A. flavus (median metabolic activity, 25% of control) compared to A. fumigatus and A. terreus (median metabolism, 42 and 53%, respectively), allowing determination of MEC with the XTT assay (93 to 100% agreement with microscopic MEC). Fungal metabolism tended to reach the lowest levels (median, 17 to 38% of control) one to two dilutions higher than the MEC, at the minimum metabolic activity concentration (MMC). For 5 of 9 A. fumigatus isolates, 6 of 12 A. terreus isolates, and 1 of 8 A. flavus isolates, a paradoxical increase in metabolism was observed at concentrations greater than the MMC. Sigmoid (E sub(max)) or bell-shaped models described accurately (median R super(2) = 0.97) the concentration-dependent metabolic changes in the absence or presence, respectively, of paradoxical response. Assessment of metabolic activity may provide useful quantitative endpoints for in vitro studies of caspofungin against Aspergillus spp. JF - Antimicrobial Agents & Chemotherapy AU - Antachopoulos, Charalampos AU - Meletiadis, Joseph AU - Sein, Tin AU - Roilides, Emmanuel AU - Walsh, Thomas J AD - Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland. Third Department of Pediatrics, Aristotle University, Hippokration Hospital, Thessaloniki, Greece Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 881 EP - 887 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 51 IS - 3 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Aspergillus flavus KW - tetrazolium salt KW - Caspofungin KW - Antifungal activity KW - Hyphae KW - Menadione KW - Aspergillus KW - Metabolism KW - Antimicrobial agents KW - Models KW - K 03340:Effects of Physical & Chemical Factors KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19986510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Concentration-Dependent+Effects+of+Caspofungin+on+the+Metabolic+Activity+of+Aspergillus+Species&rft.au=Antachopoulos%2C+Charalampos%3BMeletiadis%2C+Joseph%3BSein%2C+Tin%3BRoilides%2C+Emmanuel%3BWalsh%2C+Thomas+J&rft.aulast=Antachopoulos&rft.aufirst=Charalampos&rft.date=2007-03-01&rft.volume=196&rft.issue=3&rft.spage=259.e1&rft.isbn=&rft.btitle=&rft.title=American+journal+of+obstetrics+and+gynecology&rft.issn=1097-6868&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - tetrazolium salt; Hyphae; Antifungal activity; Caspofungin; Menadione; Metabolism; Models; Antimicrobial agents; Aspergillus flavus; Aspergillus ER - TY - JOUR T1 - Risk of second malignant neoplasms among lymphoma patients with a family history of cancer AN - 19980453; 8079257 AB - Radiotherapy and chemotherapy are known risk factors for second cancers after lymphoma. The role of genetic influences, however, remains largely unknown. We assessed risk of second cancers associated with family history of any cancer in 41,181 patients with Hodgkin lymphoma (HL) (n = 7,476), non-Hodgkin lymphoma (NHL) (n = 25,941), or chronic lymphocytic leukemia (CLL) (n = 7,764), using a large population-based database. Family history of cancer was based on a diagnosis of any cancer in 110,862 first-degree relatives. We found increased relative risk (RR) (1.81, 95% confidence interval (CI): 1.04-3.16) of breast cancer among HL patient with positive (vs. negative) family history of cancer. Among CLL patients with positive (vs. negative) family history of cancer, we observed elevated risks of bladder (RR = 3.53, 95% CI: 1.31-9.55) and prostate cancer (RR = 2.15, 95% CI: 1.17-3.94). For NHL patients with positive (vs. negative) family history of cancer, we observed non-significantly increased risk of non-melanoma skin cancer (RR = 1.94, 95% CI: 0.86-4.38) and lung cancer (RR = 1.99, 95% CI: 0.73-5.39). Our observations suggest that genetic factors, as measured by positive family history of cancer, may be influential risk-factors for selected second tumors following lymphoproliferative disorders. JF - International Journal of Cancer AU - Landgren, Ola AU - Pfeiffer, Ruth M AU - Stewart, Laveta AU - Gridley, Gloria AU - Mellemkjaer, Lene AU - Hemminki, Kari AU - Goldin, Lynn R AU - Travis, Lois B AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, landgreo@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 1099 EP - 1102 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 120 IS - 5 SN - 0020-7136, 0020-7136 KW - Immunology Abstracts; Risk Abstracts KW - Genetic factors KW - Skin KW - Hodgkin's disease KW - Urinary bladder KW - Chemotherapy KW - Skin cancer KW - Radiotherapy KW - Tumors KW - radiotherapy KW - chemotherapy KW - Immunoproliferative diseases KW - Genetics KW - Leukemia KW - Databases KW - Prostate cancer KW - Risk factors KW - Breast cancer KW - prostate cancer KW - lymphoma KW - Chronic lymphatic leukemia KW - Lung cancer KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19980453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Risk+of+second+malignant+neoplasms+among+lymphoma+patients+with+a+family+history+of+cancer&rft.au=Landgren%2C+Ola%3BPfeiffer%2C+Ruth+M%3BStewart%2C+Laveta%3BGridley%2C+Gloria%3BMellemkjaer%2C+Lene%3BHemminki%2C+Kari%3BGoldin%2C+Lynn+R%3BTravis%2C+Lois+B&rft.aulast=Landgren&rft.aufirst=Ola&rft.date=2007-03-01&rft.volume=120&rft.issue=5&rft.spage=1099&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22414 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genetic factors; Hodgkin's disease; Urinary bladder; Chemotherapy; Radiotherapy; Skin cancer; Tumors; Immunoproliferative diseases; Databases; Prostate cancer; Risk factors; Breast cancer; Chronic lymphatic leukemia; Lung cancer; Leukemia; Genetics; Skin; prostate cancer; radiotherapy; lymphoma; chemotherapy DO - http://dx.doi.org/10.1002/ijc.22414 ER - TY - JOUR T1 - Stem Cell Activity of Human Side Population and alpha 6 Integrin-Bright Keratinocytes Defined by a Quantitative In Vivo Assay AN - 19974426; 7340695 AB - The isolation and characterization of living human epithelial stem cells is difficult because distinguishing cell surface markers have not been identified with certainty. Side population keratinocytes (SP-KCs) that efflux Hoechst 33342 fluorescent dye, analogous to bone marrow-derived side population (SP) hematopoietic stem cells, have been identified in human skin, but their potential to function as keratinocyte stem cells (KSCs) in vivo is not known. On the other hand, human keratinocyte populations that express elevated levels of {szligbeta}1 and alpha 6 integrins and are distinct from SP-KCs, which express low levels of integrins, may be enriched for KSCs based on reported results of in vitro cell culture assays. When in vitro assays were used to measure total cell output of human SP-KCs and integrin-bright keratinocytes, we could not document their superior long-term proliferative activity versus unfractionated keratinocytes. To further assess the KSC characteristics in SP-KCs and integrin-bright keratinocytes, we used an in vivo competitive repopulation assay in which bioengineered human epidermis containing competing keratinocyte populations with different human major histocompatibility (MHC) class I antigens were grafted onto immunocompromised mice, and the intrinsic MHC class I antigens are used to quantify expansion of competing populations. In these in vivo studies, human SP-KCs showed little competitive expansion in vivo and were not enriched for KSCs. In contrast, keratinocytes expressing elevated levels of alpha 6 integrin and low levels of CD71 ( alpha 6-bright/CD71-dim) expanded over 200-fold during the 33-week in vivo study. These results definitively demonstrate that human alpha 6-bright/CD71-dim keratinocytes are enriched with KSCs, whereas SP-KCs are not. JF - Stem Cells AU - Terunuma, Atsushi AU - Kapoor, Veena AU - Yee, Carole AU - Telford, William G AU - Udey, Mark C AU - Vogel, Jonathan C AD - Dermatology Branch and Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 664 EP - 669 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 25 IS - 3 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts KW - Cell surface KW - Epidermis KW - Stem cells KW - Skin KW - Integrins KW - Bone marrow KW - Major histocompatibility complex KW - Fluorescent indicators KW - Cell culture KW - Keratinocytes KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19974426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Stem+Cell+Activity+of+Human+Side+Population+and+alpha+6+Integrin-Bright+Keratinocytes+Defined+by+a+Quantitative+In+Vivo+Assay&rft.au=Terunuma%2C+Atsushi%3BKapoor%2C+Veena%3BYee%2C+Carole%3BTelford%2C+William+G%3BUdey%2C+Mark+C%3BVogel%2C+Jonathan+C&rft.aulast=Terunuma&rft.aufirst=Atsushi&rft.date=2007-03-01&rft.volume=25&rft.issue=3&rft.spage=664&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Epidermis; Cell surface; Stem cells; Skin; Integrins; Bone marrow; Fluorescent indicators; Major histocompatibility complex; Cell culture; Keratinocytes ER - TY - JOUR T1 - Expression of Immunomodulatory Genes in Human Monocytes Induced by Voriconazole in the Presence of Aspergillus fumigatus AN - 19967253; 7285316 AB - We assessed the effect of voriconazole (VRC) on the expression and release of selected cytokines and chemokines in the THP-1 human monocytic cell line in response to Aspergillus fumigatus hyphal fragments (HF) by cDNA microarray analysis, reverse transcriptase (RT) PCR, and enzyme-linked immunosorbent assay. Stimulation of THP-1 cells by HF alone caused a significant up-regulation of CCL4 (MIP1B) and CCL16, while CCL2 (MCP1) was down-regulated. By comparison, in the presence of VRC, a large number of genes such as CCL3 (MIP1A), CCL4 (MIP1B), CCL5 (RANTES), CCL7 (MCP3), CCL11 (EOTAXIN), CCL15 (MIP1 Delta ), CXCL6, and CXCL13 were strongly up-regulated in THP-1 cells challenged by HF, whereas CCL20 (MIP3A) and CCL21 (MIP2) were down-regulated. Among five genes differentially expressed in THP-1 cells, IL12A, IL12B, and IL-16 were down-regulated whereas IL-11 and TGFB1 were significantly up-regulated in the presence of VRC. The inflammation-related genes IFN gamma , IL1R1, and TNFA were also up-regulated in THP-1 cells exposed to HF only in the presence of VRC. RT-PCR of four selected genes validated the results of microarrays. The release of interleukin 1{szligbeta} (IL-1{szligbeta}) and IL-12 was significantly increased from monocytes stimulated either by HF alone (P < 0.05) or in the presence of VRC (P < 0.01 and P < 0.05, respectively). In contrast, tumor necrosis factor alpha release from monocytes was enhanced only in the presence of VRC (P < 0.01). The chemokines monocyte chemoattractant protein 1 and macrophage inflammatory protein 1{szligbeta} were decreased under both conditions (P < 0.01). These results demonstrate that in the presence of VRC, HF induces a more pronounced profile of gene expression in THP-1 cells than HF alone, potentially leading to more-efficient host resistance to A. fumigatus. JF - Antimicrobial Agents & Chemotherapy AU - Simitsopoulou, M AU - Roilides, E AU - Likartsis, C AU - Ioannidis, J AU - Orfanou, A AU - Paliogianni, F AU - Walsh, T J AD - Laboratory of Infectious Diseases, 3rd Department of Pediatrics, School of Medicine, Aristotle University, Hippokration Hospital, Thessaloniki 54642, Greece. Laboratory of Medical Biotechnology, Department of Medical Laboratories, Technological Educational Institute of Thessaloniki, 57400 Thessaloniki, Greece. Immunocompromised Host Section, National Cancer Institute, Bethesda, Maryland 20892. Department of Microbiology, University of Patras Medical School, Patras 26500, Greece Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 1048 EP - 1054 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 51 IS - 3 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - Chemokines KW - CCL4 protein KW - Interleukin 1 KW - DNA microarrays KW - Immunomodulation KW - Interleukin 11 KW - Gene expression KW - Interleukin 12 KW - CXCL13 protein KW - Interleukin 16 KW - Voriconazole KW - Polymerase chain reaction KW - RNA-directed DNA polymerase KW - Cytokines KW - eotaxin KW - Monocytes KW - CCL20 protein KW - Transforming growth factor- beta 1 KW - Enzyme-linked immunosorbent assay KW - Monocyte chemoattractant protein 1 KW - CCL3 protein KW - RANTES KW - Antimicrobial agents KW - Aspergillus fumigatus KW - Chemotactic factors KW - Tumor necrosis factor- alpha KW - CCL21 protein KW - Macrophage inflammatory protein KW - A 01340:Antibiotics & Antimicrobials KW - K 03350:Immunology KW - F 06910:Microorganisms & Parasites KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19967253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Expression+of+Immunomodulatory+Genes+in+Human+Monocytes+Induced+by+Voriconazole+in+the+Presence+of+Aspergillus+fumigatus&rft.au=Simitsopoulou%2C+M%3BRoilides%2C+E%3BLikartsis%2C+C%3BIoannidis%2C+J%3BOrfanou%2C+A%3BPaliogianni%2C+F%3BWalsh%2C+T+J&rft.aulast=Simitsopoulou&rft.aufirst=M&rft.date=2007-03-01&rft.volume=51&rft.issue=3&rft.spage=1048&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Chemokines; CCL4 protein; Interleukin 1; Immunomodulation; DNA microarrays; Gene expression; Interleukin 11; Interleukin 12; CXCL13 protein; Interleukin 16; Voriconazole; Cytokines; RNA-directed DNA polymerase; Polymerase chain reaction; eotaxin; Monocytes; CCL20 protein; Transforming growth factor- beta 1; Enzyme-linked immunosorbent assay; Monocyte chemoattractant protein 1; CCL3 protein; RANTES; Antimicrobial agents; Chemotactic factors; CCL21 protein; Tumor necrosis factor- alpha; Macrophage inflammatory protein; Aspergillus fumigatus ER - TY - JOUR T1 - Polychlorinated Biphenyls and Non-Hodgkin Lymphoma AN - 19962964; 7314974 AB - Several epidemiologic studies suggest that polychlorinated biphenyl (PCB) levels measured in peripheral blood or adipose tissue are related to increased risk of non-Hodgkin lymphoma (NHL) and, therefore, may be at least partially responsible for the rising incidence of NHL unrelated to HIV infection in recent decades. Case-control studies that measured PCBs in blood, adipose tissue, or household carpet dust, at the time of diagnosis, have observed elevated NHL risk associated with concentrations of either total PCBs or of specific congeners. Similar associations have been found in a number of prospective cohorts. These associations do not seem to be due to confounding by other organochlorines or by other known NHL risk factors. These results support evidence of PCB carcinogenicity from animal studies. However, interpretation of the epidemiologic evidence is limited by the wide range in measurement precision across congeners and by the moderate to high correlation among many congeners. Occupational cohort studies provide very limited support for a relationship between PCBs and NHL. In conclusion, there is mounting evidence of a relationship between certain PCBs and risk of NHL, but important questions remain, especially regarding the magnitude, timing, and causality of that relationship. (Cancer Epidemiol Biomarkers Prev 2007; 16(3):373-6) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Engel, Lawrence S AU - Lan, Qing AU - Rothman, Nathaniel AD - Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York and Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 373 EP - 376 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 3 SN - 1055-9965, 1055-9965 KW - HIV KW - Immunology Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts; Risk Abstracts KW - Organochlorine compounds KW - adipose tissues KW - Infection KW - Dust KW - households KW - Carpets KW - Carcinogenicity KW - Risk factors KW - infection KW - prevention KW - Congeners KW - PCB compounds KW - Lymphoma KW - PCB KW - Bioindicators KW - Peripheral blood KW - biomarkers KW - Cancer KW - polychlorinated biphenyls KW - Human immunodeficiency virus KW - Adipose tissue KW - lymphoma KW - H 11000:Diseases/Injuries/Trauma KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19962964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Polychlorinated+Biphenyls+and+Non-Hodgkin+Lymphoma&rft.au=Engel%2C+Lawrence+S%3BLan%2C+Qing%3BRothman%2C+Nathaniel&rft.aulast=Engel&rft.aufirst=Lawrence&rft.date=2007-03-01&rft.volume=16&rft.issue=3&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Organochlorine compounds; Peripheral blood; Infection; biomarkers; Dust; Cancer; polychlorinated biphenyls; Carcinogenicity; Carpets; Risk factors; Congeners; Adipose tissue; Lymphoma; PCB; Bioindicators; households; prevention; infection; adipose tissues; lymphoma; PCB compounds; Human immunodeficiency virus ER - TY - JOUR T1 - Fragment complementation for the co-refolding of Thermotoga maritima beta -glucosidase by gene splitting at non-homologous region AN - 19887731; 7584166 AB - beta -Glucosidase from Thermotoga maritima is a 721 amino acid protein consisting of structurally distinct non-homologous region connecting the N- and C-terminal domains. To investigate the functional role of the non-homologous region in co-refolding, the gene was split at four sites (370, 403, 419 and 435) of the non-homologous region, cloned and separately expressed in E. coli generating eight peptide fragments (N370, N403, N419, N435, 371C, 404C, 420C and 436C). All eight fragments were recovered as insoluble inclusion bodies and found to be catalytically inactive. No catalytic activity was observed when these eight fragments were refolded individually. However, the catalytic activity was recovered when the two fragments derived from N- and C-terminal peptides were co-refolded together. Truncation of almost all amino acid residues in non-homologous region resulted in extremely low catalytic activity, which strongly suggests that non-homologous region is very important for the proper refolding of the peptides to reconstitute the catalytic activity. We succeeded in refolding the protein into an active form after splitting the gene at non-homologous region, denaturing and co-refolding the two domains. These results demonstrates the importance of structural elements that are not involved in the active site play an important role in protein folding to assemble the active site elements. JF - Enzyme and Microbial Technology AU - Kim, Bong-Jo AU - Mangala, Selanere L AU - Muralidhara, B K AU - Hayashi, Kiyoshi AD - Enzyme Laboratory, National Food Research Institute, 2-1-12 Kannondai, Tsukuba 305-8642, Japan, bjkim@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 732 EP - 739 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 40 IS - 4 SN - 0141-0229, 0141-0229 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; ASFA Marine Biotechnology Abstracts KW - beta -Glucosidase KW - Thermotoga maritima KW - Non-homologous region KW - Co-refolding KW - Gene splitting KW - Inclusion bodies KW - Fragment complementation KW - Amino acids KW - Complementation KW - Protein folding KW - Escherichia coli KW - Enzymes KW - Splitting KW - J 02310:Genetics & Taxonomy KW - G 07880:Human Genetics KW - Q4 27760:Microorganisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19887731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Enzyme+and+Microbial+Technology&rft.atitle=Fragment+complementation+for+the+co-refolding+of+Thermotoga+maritima+beta+-glucosidase+by+gene+splitting+at+non-homologous+region&rft.au=Kim%2C+Bong-Jo%3BMangala%2C+Selanere+L%3BMuralidhara%2C+B+K%3BHayashi%2C+Kiyoshi&rft.aulast=Kim&rft.aufirst=Bong-Jo&rft.date=2007-03-01&rft.volume=40&rft.issue=4&rft.spage=732&rft.isbn=&rft.btitle=&rft.title=Enzyme+and+Microbial+Technology&rft.issn=01410229&rft_id=info:doi/10.1016%2Fj.enzmictec.2006.06.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Complementation; Amino acids; Protein folding; Enzymes; Inclusion bodies; beta -Glucosidase; Splitting; Escherichia coli; Thermotoga maritima DO - http://dx.doi.org/10.1016/j.enzmictec.2006.06.005 ER - TY - JOUR T1 - The Broad Antibacterial Activity of the Natural Antibody Repertoire Is Due to Polyreactive Antibodies AN - 19806733; 8569599 AB - Polyreactive antibodies bind to a variety of structurally unrelated antigens. The function of these antibodies, however, has remained an enigma, and because of their low binding affinity their biological relevance has been questioned. Using a panel of monoclonal polyreactive antibodies, we showed that these antibodies can bind to both Gram-negative and Gram-positive bacteria and acting through the classical complement pathway can inhibit bacterial growth by lysis, generate anaphylatoxin C5a, enhance phagocytosis, and neutralize the functional activity of endotoxin. Polyreactive antibody- enriched, but not polyreactive antibody-reduced, IgM prepared from normal human serum displays antibacterial activity similar to that of monoclonal polyreactive IgM. We conclude that polyreactive antibodies are a major contributor to the broad antibacterial activity of the natural antibody repertoire. JF - Cell Host & Microbe AU - Zhou, Zhao-Hua AU - Zhang, Yahong AU - Hu, Ya-Fang AU - Wahl, Larry M AU - Cisar, John O AU - Notkins, Abner Louis AD - Experimental Medicine Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA, anotkins@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 51 EP - 61 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 1 IS - 1 SN - 1931-3128, 1931-3128 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - MICROBIO KW - CELLIMMUNO KW - MOLIMMUNO KW - Endotoxins KW - Anaphylatoxin C5a KW - Antibacterial activity KW - Monoclonal antibodies KW - Gram-positive bacteria KW - Phagocytosis KW - Immunoglobulin M KW - A 01340:Antibiotics & Antimicrobials KW - F 06910:Microorganisms & Parasites KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19806733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+Host+%26+Microbe&rft.atitle=The+Broad+Antibacterial+Activity+of+the+Natural+Antibody+Repertoire+Is+Due+to+Polyreactive+Antibodies&rft.au=Zhou%2C+Zhao-Hua%3BZhang%2C+Yahong%3BHu%2C+Ya-Fang%3BWahl%2C+Larry+M%3BCisar%2C+John+O%3BNotkins%2C+Abner+Louis&rft.aulast=Zhou&rft.aufirst=Zhao-Hua&rft.date=2007-03-01&rft.volume=27&rft.issue=2&rft.spage=1167&rft.isbn=&rft.btitle=&rft.title=Anticancer+research&rft.issn=02507005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Endotoxins; Anaphylatoxin C5a; Antibacterial activity; Monoclonal antibodies; Gram-positive bacteria; Phagocytosis; Immunoglobulin M DO - http://dx.doi.org/10.1016/j.chom.2007.01.002 ER - TY - JOUR T1 - Specialized mismatch repair function of Glu339 in the Phe-X-Glu motif of yeast Msh6 AN - 19794620; 7324938 AB - The major eukaryotic mismatch repair (MMR) pathway requires Msh2-Msh6, which, like Escherichia coli MutS, binds to and participates in repair of the two most common replication errors, single base-base and single base insertion-deletion mismatches. For both types of mismatches, the side chain of E. coli Glu38 in a conserved Phe-X-Glu motif interacts with a mismatched base. The O approximately equal to of Glu38 forms a hydrogen bond with either the N7 of purines or the N3 of pyrimidines. We show here that changing E. coli Glu38 to alanine results in nearly complete loss of repair of both single base-base and single base deletion mismatches. In contrast, a yeast strain with alanine replacing homologous Glu339 in Msh6 has nearly normal repair for insertion-deletion and most base-base mismatches, but is defective in repairing base-base mismatches characteristic of oxidative stress, e.g. 8-oxo-G.A mismatches. The results suggest that bacterial MutS and yeast Msh2-Msh6 differ in how they recognize and/or process replication errors involving undamaged bases, and that Glu339 in Msh6 may have a specialized role in repairing mismatches containing oxidized bases. JF - DNA Repair AU - Holmes, S F AU - Scarpinato, K D AU - McCulloch, S D AU - Schaaper, R M AU - Kunkel, T A AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States, kunkel@niehs.nih.gov Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 SP - 293 EP - 303 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 6 IS - 3 SN - 1568-7864, 1568-7864 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Biochemistry Abstracts 2: Nucleic Acids KW - Gene deletion KW - mismatch repair KW - Alanine KW - Replication KW - Hydrogen bonding KW - Oxidative stress KW - Escherichia coli KW - pyrimidines KW - DNA repair KW - MSH6 protein KW - purines KW - N 14820:DNA Metabolism & Structure KW - J 02490:Miscellaneous KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19794620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+Repair&rft.atitle=Specialized+mismatch+repair+function+of+Glu339+in+the+Phe-X-Glu+motif+of+yeast+Msh6&rft.au=Holmes%2C+S+F%3BScarpinato%2C+K+D%3BMcCulloch%2C+S+D%3BSchaaper%2C+R+M%3BKunkel%2C+T+A&rft.aulast=Holmes&rft.aufirst=S&rft.date=2007-03-01&rft.volume=6&rft.issue=3&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=DNA+Repair&rft.issn=15687864&rft_id=info:doi/10.1016%2Fj.dnarep.2006.10.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gene deletion; mismatch repair; Alanine; Oxidative stress; Hydrogen bonding; Replication; pyrimidines; DNA repair; purines; MSH6 protein; Escherichia coli DO - http://dx.doi.org/10.1016/j.dnarep.2006.10.023 ER - TY - JOUR T1 - Psoralen Conjugates for Visualization of Genomic Interstrand Cross-Links Localized by Laser Photoactivation AN - 19788024; 7650982 AB - DNA interstrand cross-links are formed by chemotherapy drugs as well as by products of normal oxidative metabolism. Despite their importance, the pathways of cross-link metabolism are poorly understood. Laser confocal microscopy has become a powerful tool for studying the repair of DNA lesions that can be detected by immunofluorescent reagents. In order to apply this approach to cross-link repair, we have synthesized conjugates of 4,5',8-trimethylpsoralen (TMP) and easily detected compounds such as Lissamine rhodamine B sulfonyl chloride (LRB-SC), biotin, and digoxigenin. These conjugates are activated by UVA, and we have analyzed the intracellular localization of DNA damage and DNA reactivity by confocal and immunofluorescence microscopy. The LRB-SC-TMP conjugate 2 appeared mainly in the mitochondria, while the biotin-TMP conjugate 4 preferentially localized in the cytoplasm. Adducts formed by UVA and digoxigenin conjugates of TMP 7a and 4,5'-dimethylangelicin (DMA) 7b, which forms only monoadducts, were largely localized to the nucleus. Exposure of cells incubated with 7a and 7b to a 364 nm UV laser directed toward defined nuclear regions of interest resulted in localized adduct formation which could be visualized by immunofluorescence. Repair-proficient cells were able to remove the photoadducts, while repair-deficient cells were unable to repair the damage. The results indicated that the digoxigenin-TMP conjugate 7a and digoxigenin-DMA conjugate 7b can be used for studying the repair of laser localized DNA monoadducts and cross-links. JF - Bioconjugate Chemistry AU - Thazhathveetil, A K AU - Liu, S-T AU - Indig, F E AU - Seidman, M M AD - Laboratory of Molecular Gerontology, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 431 EP - 437 VL - 18 IS - 2 SN - 1043-1802, 1043-1802 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Chemotherapy KW - Adducts KW - Digoxigenin KW - Mitochondria KW - Chloride KW - Immunofluorescence KW - DNA repair KW - psoralen KW - Oxidative metabolism KW - DNA damage KW - Cytoplasm KW - Confocal microscopy KW - Lasers KW - genomics KW - Photoactivation KW - Nuclei KW - Biotin KW - rhodamine KW - Drugs KW - G 07720:Immunogenetics KW - W 30940:Products KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19788024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Concentration-Dependent+Effects+of+Caspofungin+on+the+Metabolic+Activity+of+Aspergillus+Species&rft.au=Antachopoulos%2C+Charalampos%3BMeletiadis%2C+Joseph%3BSein%2C+Tin%3BRoilides%2C+Emmanuel%3BWalsh%2C+Thomas+J&rft.aulast=Antachopoulos&rft.aufirst=Charalampos&rft.date=2007-03-01&rft.volume=51&rft.issue=3&rft.spage=881&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Digoxigenin; Adducts; Chemotherapy; Mitochondria; Chloride; Immunofluorescence; DNA repair; psoralen; Oxidative metabolism; DNA damage; Cytoplasm; Confocal microscopy; Lasers; Photoactivation; genomics; Nuclei; Drugs; rhodamine; Biotin DO - http://dx.doi.org/10.1021/bc060309t ER - TY - JOUR T1 - Improved Antibacterial Host Defense and Altered Peripheral Granulocyte Homeostasis in Mice Lacking the Adhesion Class G Protein Receptor CD97 AN - 19782161; 7287780 AB - CD97 is a member of the adhesion family of G protein-coupled receptors. Alternatively spliced forms of CD97 bind integrins alpha 5{szligbeta}1 and alpha v{szligbeta}3, decay accelerating factor, or dermatan sulfate. CD97 is expressed on myeloid cells at high levels and a variety of other cell types at lower levels. Little is known about the physiological function of CD97. To begin dissecting the function of CD97, we evaluated the immune response of CD97 null mice to systemic infection by Listeria monocytogenes. CD97 null mice were significantly more resistant to listeriosis than matched wild-type mice. A major determinant of the difference in survival appeared to be the comparatively more robust accumulation of granulocytes in the blood and in infected livers of CD97 null mice within 18 h of inoculation, correlating with a decrease in the number of bacteria. CD97 null mice also displayed a mild granulocytosis in the nonchallenged state. Because there is a strong suggestion that CD97 functions in an adhesive capacity, we examined the migratory properties of granulocytes in CD97 null mice. In chimeric animals, CD97 null and wild-type granulocytes migrated similarly, as determined by inflammation-induced emigration from the bone marrow and accumulation in the peritoneum. Granulocyte development in the bone marrow of CD97 null mice was comparable to that of wild-type mice, and CD97 deficiency did not appear to stimulate granulocytosis secondary to peripheral inflammation and resultant granulocyte colony-stimulating factor induction, unlike various other models of adhesion deficiencies. Our results suggest that CD97 plays a role in peripheral granulocyte homeostasis. JF - Infection and Immunity AU - Wang, Tao AU - Tian, Linhua AU - Haino, Makoto AU - Gao, Ji-Liang AU - Lake, Ross AU - Ward, Yvona AU - Wang, Hongshan AU - Siebenlist, Ulrich AU - Murphy, Philip M AU - Kelly, Kathleen AD - Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute. Laboratory of Host Defenses. Laboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20878 Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 1144 EP - 1153 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 3 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Listeriosis KW - Disseminated infection KW - Bone marrow KW - Animal models KW - Survival KW - Granulocyte colony-stimulating factor KW - Homeostasis KW - Myeloid cells KW - G protein-coupled receptors KW - Integrins KW - Cell migration KW - Adhesives KW - Listeria monocytogenes KW - double prime G protein-coupled receptors KW - Peritoneum KW - Guanine nucleotide-binding protein KW - Alternative splicing KW - Sulfate KW - Inflammation KW - Leukocytes (granulocytic) KW - Blood KW - Inoculation KW - Liver KW - decay-accelerating factor KW - Immune response KW - A 01340:Antibiotics & Antimicrobials KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19782161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Improved+Antibacterial+Host+Defense+and+Altered+Peripheral+Granulocyte+Homeostasis+in+Mice+Lacking+the+Adhesion+Class+G+Protein+Receptor+CD97&rft.au=Wang%2C+Tao%3BTian%2C+Linhua%3BHaino%2C+Makoto%3BGao%2C+Ji-Liang%3BLake%2C+Ross%3BWard%2C+Yvona%3BWang%2C+Hongshan%3BSiebenlist%2C+Ulrich%3BMurphy%2C+Philip+M%3BKelly%2C+Kathleen&rft.aulast=Wang&rft.aufirst=Tao&rft.date=2007-03-01&rft.volume=75&rft.issue=3&rft.spage=1144&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Listeriosis; double prime G protein-coupled receptors; Disseminated infection; Peritoneum; Animal models; Bone marrow; Survival; Guanine nucleotide-binding protein; Homeostasis; Granulocyte colony-stimulating factor; Myeloid cells; Inflammation; Sulfate; Alternative splicing; Blood; Leukocytes (granulocytic); G protein-coupled receptors; Integrins; Liver; Inoculation; decay-accelerating factor; Cell migration; Immune response; Adhesives; Listeria monocytogenes ER - TY - JOUR T1 - Cell-Cell and Cell-Extracellular Matrix Interactions Regulate Embryonic Stem Cell Differentiation AN - 19779631; 7340683 AB - Cell interactions with the extracellular matrix (ECM) play a critical role in their physiology. Here, we sought to determine the role of exogenous and endogenous ECM in the differentiation of nonhuman primate ESCs. We evaluated cell differentiation from expression of lineage gene mRNA and proteins using real-time polymerase chain reaction and immunohistochemistry. We found that ESCs that attached to and spread upon highly adhesive collagen do not differentiate efficiently, whereas on the less adhesive Matrigel, ESCs form aggregates and differentiate along mesoderm and especially endoderm lineages. To further decrease ESC attachment to the substrate, we cultured them either on nonadhesive agarose or in suspension. In both cases, ESCs formed aggregates and efficiently differentiated along endoderm and mesoderm lineages, most strikingly into cardiomyocytes. Aggregates formed by thus-differentiated ESCs started to beat with a frequency of 50-100 beats per minute and continued to beat for approximately a month. In spite of the presence of exogenous ECM, ESCs were dependent on endogenous ECM for their survival and differentiation, as the inhibition of endogenous collagen induced a gradual loss of ESCs and neither a simple matrix, such as type I collagen, nor the complex matrix Matrigel was able to rescue these cells. In conclusion, adhesiveness to various ECM and nonbiological substrates determines the differentiation of ESCs in such a way that efficient cell-cell aggregation, together with less efficient cell attachment and spreading, results in more efficient cell differentiation. JF - Stem Cells AU - Chen, Silvia S AU - Fitzgerald, Wendy AU - Zimmerberg, Joshua AU - Kleinman, Hynda K AU - Margolis, Leonid AD - Laboratory of Cellular and Molecular Biophysics and NASA/NIH Center for Three-Dimensional Tissue Culture, National Institute of Child Health and Human Development and Cell Biology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland, USA Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 553 EP - 561 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 25 IS - 3 SN - 1066-5099, 1066-5099 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Cell survival KW - cardiomyocytes KW - Primates KW - Mesoderm KW - Cell adhesion KW - mRNA KW - Differentiation KW - Stem cells KW - Embryo cells KW - Extracellular matrix KW - Polymerase chain reaction KW - Endoderm KW - Cell migration KW - Cell interactions KW - Adhesives KW - Collagen (type I) KW - Immunohistochemistry KW - G 07730:Development & Cell Cycle KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19779631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Cell-Cell+and+Cell-Extracellular+Matrix+Interactions+Regulate+Embryonic+Stem+Cell+Differentiation&rft.au=Chen%2C+Silvia+S%3BFitzgerald%2C+Wendy%3BZimmerberg%2C+Joshua%3BKleinman%2C+Hynda+K%3BMargolis%2C+Leonid&rft.aulast=Chen&rft.aufirst=Silvia&rft.date=2007-03-01&rft.volume=25&rft.issue=3&rft.spage=553&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cell survival; cardiomyocytes; Mesoderm; mRNA; Cell adhesion; Differentiation; Stem cells; Embryo cells; Extracellular matrix; Polymerase chain reaction; Endoderm; Cell interactions; Cell migration; Adhesives; Immunohistochemistry; Collagen (type I); Primates ER - TY - JOUR T1 - Comparing two approaches for aligning representations of anatomy AN - 19706733; 7497175 AB - Objective: To analyze the comparison, through their results, of two distinct approaches applied to aligning two representations of anatomy. Materials: Both approaches use a combination of lexical and structural techniques. In addition, the first approach takes advantage of domain knowledge, while the second approach treats alignment as a special case of schema matching. The same versions of FMA and GALEN were aligned by each approach. Two thousand one hundred and ninety-nine concept matches were obtained by both approaches. Methods and results: For matches identified by one approach only (337 and 336, respectively), we analyzed the reasons that caused the other approach to fail. Conclusions: The first approach could be improved by addressing partial lexical matches and identifying matches based solely on structural similarity. The second approach may be improved by taking into account synonyms in FMA and identifying semantic mismatches. However, only 33% of the possible one-to-one matches among anatomical concepts were identified by the two approaches together. New directions need to be explored in order to handle more complex matches. JF - Artificial Intelligence in Medicine AU - Zhang, S AU - Mork, P AU - Bodenreider, O AU - Bernstein, P A AD - National Institutes of Health, Bethesda, MD, USA, smzhang@math.ac.cn Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 227 EP - 236 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 39 IS - 3 SN - 0933-3657, 0933-3657 KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - Language KW - Semantics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19706733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Artificial+Intelligence+in+Medicine&rft.atitle=Comparing+two+approaches+for+aligning+representations+of+anatomy&rft.au=Zhang%2C+S%3BMork%2C+P%3BBodenreider%2C+O%3BBernstein%2C+P+A&rft.aulast=Zhang&rft.aufirst=S&rft.date=2007-03-01&rft.volume=39&rft.issue=3&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Artificial+Intelligence+in+Medicine&rft.issn=09333657&rft_id=info:doi/10.1016%2Fj.artmed.2006.12.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Computer programs; Language; Semantics DO - http://dx.doi.org/10.1016/j.artmed.2006.12.002 ER - TY - JOUR T1 - Adolescents as victims of familial violence: a hospital based surveillance AN - 19668777; 7423937 AB - Adolescent abuse is an important and understudied issue in society. The objective of this study was to examine the epidemiology of physical injuries due to maltreatment among adolescents aged 10-19 years. Subjects came from seven hospitals/trauma centres in Washington DC that were involved in the Washington DC Initiative to Reduce Infant Mortality and Prevention of Childhood Injuries Study. From 1996-1998, information was gathered about all injuries to adolescents aged 10-19 years that resulted in a visit to a participating emergency department. This paper focuses on the subset 178 adolescents aged 10--19 years who presented with physical injuries due to maltreatment. It was found that 55% of victims of abuse were female. Abuse victims were more likely to be female than those with unintentional injury. The most common injuries were contusions to the extremities (29%). Mothers were the most common perpetrators (48%). A total of 64% of victims were assaulted with an object/weapon and the most common object used was a belt. There are some similarities and some important differences between patterns of maltreatment in adolescents vs. younger children. Increased awareness of maltreatment among older children is a critical step in increasing and improving screening and prevention practices among health-care professionals. JF - International Journal of Injury Control and Safety Promotion AU - Saluja, G AU - Marquez, V AU - Cheng, T L AU - Trumble, A AU - Brenner, R A AD - National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (DESPR/NICHD/NIH), 6100 Executive Blvd., Room 7B03, Bethesda, MD 20892-7510, USA, salujag@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 19 EP - 23 VL - 14 IS - 1 SN - 1745-7300, 1745-7300 KW - Health & Safety Science Abstracts KW - Weapons KW - Injuries KW - infant mortality KW - prevention KW - Children KW - extremities KW - Violence KW - Adolescents KW - Emergency medical services KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19668777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Injury+Control+and+Safety+Promotion&rft.atitle=Adolescents+as+victims+of+familial+violence%3A+a+hospital+based+surveillance&rft.au=Saluja%2C+G%3BMarquez%2C+V%3BCheng%2C+T+L%3BTrumble%2C+A%3BBrenner%2C+R+A&rft.aulast=Saluja&rft.aufirst=G&rft.date=2007-03-01&rft.volume=14&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Injury+Control+and+Safety+Promotion&rft.issn=17457300&rft_id=info:doi/10.1080%2F17457300601049618 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Weapons; infant mortality; Injuries; prevention; extremities; Children; Violence; Adolescents; Emergency medical services DO - http://dx.doi.org/10.1080/17457300601049618 ER - TY - JOUR T1 - snp.plotter: an R-based SNP/haplotype association and linkage disequilibrium plotting package AN - 19658088; 7404163 AB - SUMMARY: snp.plotter is a newly developed R package which produces high-quality plots of results from genetic association studies. The main features of the package include options to display a linkage disequilibrium (LD) plot below the P-value plot using either the r super(2) or D' LD metric, to set the X-axis to equal spacing or to use the physical map of markers, and to specify plot labels, colors, symbols and LD heatmap color scheme. snp.plotter can plot single SNP and/or haplotype data and simultaneously plot multiple sets of results. R is a free software environment for statistical computing and graphics available for most platforms. The proposed package provides a simple way to convey both association and LD information in a single appealing graphic for genetic association studies. AVAILABILITY: Downloadable R package and example datasets are available at http://cbdb.nimh.nih.gov/~kristin/snp.plotter.html and http://www.r-project.org CONTACT: nicodemuskail.nih.gov JF - Bioinformatics AU - Luna, Augustin AU - Nicodemus, Kristin K AD - GCAP/CBDB, NIMH/NIH, 10 Center Drive Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 774 EP - 776 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 23 IS - 6 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Linkage disequilibrium KW - Computer programs KW - software KW - Statistics KW - Haplotypes KW - Single-nucleotide polymorphism KW - Bioinformatics KW - Color KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19658088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=snp.plotter%3A+an+R-based+SNP%2Fhaplotype+association+and+linkage+disequilibrium+plotting+package&rft.au=Luna%2C+Augustin%3BNicodemus%2C+Kristin+K&rft.aulast=Luna&rft.aufirst=Augustin&rft.date=2007-03-01&rft.volume=23&rft.issue=6&rft.spage=774&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Computer programs; Linkage disequilibrium; software; Statistics; Haplotypes; Single-nucleotide polymorphism; Bioinformatics; Color ER - TY - JOUR T1 - Revisiting the Basic Reproductive Number for Malaria and Its Implications for Malaria Control AN - 19644638; 7384397 AB - The prospects for the success of malaria control depend, in part, on the basic reproductive number for malaria, R sub(0). Here, we estimate R sub(0) in a novel way for 121 African populations, and thereby increase the number of R sub(0) estimates for malaria by an order of magnitude. The estimates range from around one to more than 3,000. We also consider malaria transmission and control in finite human populations, of size H. We show that classic formulas approximate the expected number of mosquitoes that could trace infection back to one mosquito after one parasite generation, Z sub(0)(H), but they overestimate the expected number of infected humans per infected human, R sub(0)(H). Heterogeneous biting increases R sub(0) and, as we show, Z sub(0)(H), but we also show that it sometimes reduces R sub(0)(H); those who are bitten most both infect many vectors and absorb infectious bites. The large range of R sub(0) estimates strongly supports the long-held notion that malaria control presents variable challenges across its transmission spectrum. In populations where R sub(0) is highest, malaria control will require multiple, integrated methods that target those who are bitten most. Therefore, strategic planning for malaria control should consider R sub(0), the spatial scale of transmission, human population density, and heterogeneous biting. JF - PLoS Biology AU - Smith, David L AU - McKenzie, FEllis AU - Snow, Robert W AU - Hay, Simon I AD - Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America Y1 - 2007/03// PY - 2007 DA - Mar 2007 PB - Public Library of Science, 185 Berry Street Suite 1300 San Francisco CA 94107 USA, [mailto:plos@plos.org], [URL:http://www.plos.org] VL - 5 IS - 3 SN - 1544-9173, 1544-9173 KW - Sustainability Science Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Parasites KW - Population density KW - human population density KW - Malaria KW - Infection KW - Disease transmission KW - Biting KW - malaria KW - bites KW - infection KW - Africa KW - human populations KW - M3 1010:Issues in Sustainable Development KW - K 03400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19644638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Biology&rft.atitle=Revisiting+the+Basic+Reproductive+Number+for+Malaria+and+Its+Implications+for+Malaria+Control&rft.au=Smith%2C+David+L%3BMcKenzie%2C+FEllis%3BSnow%2C+Robert+W%3BHay%2C+Simon+I&rft.aulast=Smith&rft.aufirst=David&rft.date=2007-03-01&rft.volume=5&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Biology&rft.issn=15449173&rft_id=info:doi/10.1371%2Fjournal.pbio.0050042 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Parasites; Biting; Population density; Malaria; Infection; Disease transmission; malaria; bites; infection; human population density; human populations; Africa DO - http://dx.doi.org/10.1371/journal.pbio.0050042 ER - TY - JOUR T1 - A case study of gait compensations for hip muscle weakness in idiopathic inflammatory myopathy AN - 19637334; 7378221 AB - Background The purpose of this case series was to quantify different strategies used to compensate in gait for hip muscle weakness. Methods An instrumented gait analysis was performed of three females diagnosed with idiopathic inflammatory myopathies and compared to a healthy unimpaired subject. Lower extremity joint moments obtained from the gait analysis were used to drive an induced acceleration model which determined each moments contribution to upright support, forward progression, and hip joint acceleration. Findings Results showed that after midstance, the ankle plantar flexors normally provide upright support and forward progression while producing hip extension acceleration. In normal gait, the hip flexors eccentrically resist hip extension, but the hip flexor muscles of the impaired subjects (S1-3) were too weak to control extension. Instead S1-3 altered joint positions and muscle function to produce forward progression while minimizing hip extension acceleration. S1 increased knee flexion angle to decrease the hip extension effect of the ankle plantar flexors. S2 and S3 used either a knee flexor moment or gravity to produce forward progression, which had the advantage of accelerating the hip into flexion rather than extension, and decreased the demand on the hip flexors. Interpretation Results showed how gait compensations for hip muscle weakness can produce independent (i.e. successful) ambulation, although at a reduced speed as compared to normal gait. Knowledge of these successful strategies can assist the rehabilitation of patients with hip muscle weakness who are unable to ambulate and potentially be used to reduce their disability. JF - Clinical Biomechanics AU - Siegel, Karen Lohmann AU - Kepple, Thomas M AU - Stanhope, Steven J Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 319 EP - 326 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 22 IS - 3 SN - 0268-0033, 0268-0033 KW - Physical Education Index KW - Myositis KW - Muscle weakness KW - Hip KW - Gait KW - Muscles (function) KW - Handicapped KW - Rehabilitation KW - Gravity KW - Strategy KW - Ankles KW - Knees KW - Patients KW - Health KW - Legs KW - Muscles (fatigue) KW - Acceleration KW - Hips KW - Knowledge KW - Joints KW - Speed KW - Case studies KW - Analysis KW - Biomechanics KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19637334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Biomechanics&rft.atitle=A+case+study+of+gait+compensations+for+hip+muscle+weakness+in+idiopathic+inflammatory+myopathy&rft.au=Siegel%2C+Karen+Lohmann%3BKepple%2C+Thomas+M%3BStanhope%2C+Steven+J&rft.aulast=Siegel&rft.aufirst=Karen&rft.date=2007-03-01&rft.volume=22&rft.issue=3&rft.spage=319&rft.isbn=&rft.btitle=&rft.title=Clinical+Biomechanics&rft.issn=02680033&rft_id=info:doi/10.1016%2Fj.clinbiomech.2006.11.002 LA - English DB - Physical Education Index N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Handicapped; Muscles (function); Rehabilitation; Gravity; Strategy; Knees; Ankles; Legs; Health; Patients; Muscles (fatigue); Acceleration; Knowledge; Hips; Joints; Speed; Case studies; Analysis; Gait; Biomechanics DO - http://dx.doi.org/10.1016/j.clinbiomech.2006.11.002 ER - TY - JOUR T1 - Recombinant production of @@iPenicillium oxalicum@ PJ3 phytase in @@iPichia Pastoris@ AN - 19636922; 7366239 AB - The 1,332 bp phytase gene of @@iPenicillium@@@ioxalicum@ PJ3 was inserted into the expression vector, pPICZ^aA and expressed in the methylotrophic yeast, @@iPichia pastoris@ as an active, extracellular phytase. The recombinant phytase reached a maximum yield of 12 U/ml of medium at 120 h of cultivation after methanol induction under shake-flask conditions. The enzyme was glycosylated, with a molecular mass of about 62.5 kDa. The Michaelis constant (@@iK@@@dm@) and maximum reaction rate (@@iV@@@dmax@) for sodium phytate was 0.37 mM and 526.3 U/mg of protein, respectively. The optimal activity occurred at pH 4.5 and 55^'C. JF - World Journal of Microbiology & Biotechnology AU - Lee, Jaecheon AU - Choi, Yunjaie AU - Lee, Peter-Changwhan AU - Kang, Seungha AU - Bok, Jinduck AU - Cho, Jaiesoon AD - Inositol Signaling Group, LST, National Institute of Environmental Health Sciences, NIH, DHSS, Durham, NC, 27709, USA, cho3@niehs.nih.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 443 EP - 446 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 23 IS - 3 SN - 0959-3993, 0959-3993 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - phytase KW - Penicillium oxalicum KW - Methanol KW - Enzymes KW - sodium phytate KW - Expression vectors KW - Pichia pastoris KW - pH effects KW - W 30925:Genetic Engineering KW - K 03300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19636922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=World+Journal+of+Microbiology+%26+Biotechnology&rft.atitle=Recombinant+production+of+%40%40iPenicillium+oxalicum%40+PJ3+phytase+in+%40%40iPichia+Pastoris%40&rft.au=Lee%2C+Jaecheon%3BChoi%2C+Yunjaie%3BLee%2C+Peter-Changwhan%3BKang%2C+Seungha%3BBok%2C+Jinduck%3BCho%2C+Jaiesoon&rft.aulast=Lee&rft.aufirst=Jaecheon&rft.date=2007-03-01&rft.volume=23&rft.issue=3&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=World+Journal+of+Microbiology+%26+Biotechnology&rft.issn=09593993&rft_id=info:doi/10.1007%2Fs11274-006-9236-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Pichia pastoris; Penicillium oxalicum; phytase; Expression vectors; pH effects; sodium phytate; Methanol; Enzymes DO - http://dx.doi.org/10.1007/s11274-006-9236-z ER - TY - JOUR T1 - Lead Exposure, IQ, and Behavior in Urban 5- to 7-Year-Olds: Does Lead Affect Behavior Only by Lowering IQ? AN - 19618895; 7340228 AB - BACKGROUND. Lead exposure in childhood lowers IQ scores, but its effect on children's behavior is less clear. Because IQ, per se, affects behavior, measuring the direct effect of lead requires measuring and then adjusting for IQ. In addition, either peak blood lead concentration, usually at 2 years old, or the lower blood lead level measured at school age may be the most relevant. Few studies have all of this information. OBJECTIVES. The purpose of this work was to differentiate the direct effect of lead on behavior and the indirect effect through IQ and to examine the strength of the association for peak and concurrent blood lead concentration. METHODS. Data come from a clinical trial of the chelating drug succimer to prevent cognitive impairment in 780 urban 12- to 33-month-olds with blood lead concentrations of 20 to 44 mu g/dL. The children were followed from ages 2 to 7 years. The trial data were analyzed as a prospective observational study. RESULTS. Blood lead concentration at 2 years old was not associated with Conners' Parent Rating Scale-Revised scores at 5 years of age or Behavioral Assessment Systems for Children scores at 7 years of age. Blood lead level at 7 years of age had direct effects on the Behavioral Assessment Systems for Children behavioral symptoms index, externalizing, and school problems at age 7. CONCLUSIONS. Concurrent blood lead concentration was associated with externalizing and school problems scales at 7 years of age, and the effect was not entirely mediated through the effect of lead on IQ. JF - Pediatrics AU - Chen, Aimin AU - Cai, Bo AU - Dietrich, Kim N AU - Radcliffe, Jerilynn AU - Rogan, Walter J AD - Epidemiology Branch. Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina. Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio. Department of Psychology, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - E650 EP - E658 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 119 IS - 3 SN - 0031-4005, 0031-4005 KW - Toxicology Abstracts; Health & Safety Science Abstracts; CSA Neurosciences Abstracts KW - succimer KW - Data processing KW - clinical trials KW - Children KW - Clinical trials KW - Lead KW - Blood levels KW - Intelligence KW - Blood KW - Behavior KW - Cognitive ability KW - Neurotoxicity KW - Drugs KW - N3 11028:Neuropharmacology & toxicology KW - H 14000:Toxicology KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19618895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Lead+Exposure%2C+IQ%2C+and+Behavior+in+Urban+5-+to+7-Year-Olds%3A+Does+Lead+Affect+Behavior+Only+by+Lowering+IQ%3F&rft.au=Chen%2C+Aimin%3BCai%2C+Bo%3BDietrich%2C+Kim+N%3BRadcliffe%2C+Jerilynn%3BRogan%2C+Walter+J&rft.aulast=Chen&rft.aufirst=Aimin&rft.date=2007-03-01&rft.volume=119&rft.issue=3&rft.spage=E650&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - succimer; Blood; Intelligence; Data processing; Cognitive ability; Children; Drugs; Clinical trials; Lead; Blood levels; Behavior; Neurotoxicity; clinical trials ER - TY - JOUR T1 - Spiral structure of Escherichia coli HU alpha beta provides foundation for DNA supercoiling AN - 19616797; 7340402 AB - We determined the crystal structure of the Escherichia coli nucleoid-associated HU alpha beta protein by x-ray diffraction and observed that the heterodimers form multimers with octameric units in three potential arrangements, which may serve specialized roles in different DNA transaction reactions. It is of special importance that one of the structures forms spiral filaments with left-handed rotations. A negatively superhelical DNA can be modeled to wrap around this left-handed HU alpha beta multimer. Whereas the wild-type HU generated negative DNA supercoiling in vitro, an engineered heterodimer with an altered amino acid residue critical for the formation of the left-handed spiral protein in the crystal was defective in the process, thus providing the structural explanation for the classical property of HU to restrain negative supercoils in DNA. JF - Proceedings of the National Academy of Sciences, USA AU - Guo, Fusheng AU - Adhya, Sankar AD - Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892-4264 Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 4309 EP - 4314 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 11 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Handedness KW - Amino acids KW - Supercoiling KW - Superhelical DNA KW - Escherichia coli KW - Crystal structure KW - Crystals KW - X-ray diffraction KW - Filaments KW - J 02330:Biochemistry KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19616797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Spiral+structure+of+Escherichia+coli+HU+alpha+beta+provides+foundation+for+DNA+supercoiling&rft.au=Guo%2C+Fusheng%3BAdhya%2C+Sankar&rft.aulast=Guo&rft.aufirst=Fusheng&rft.date=2007-03-01&rft.volume=104&rft.issue=11&rft.spage=4309&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Handedness; Amino acids; Supercoiling; Superhelical DNA; Crystal structure; Crystals; X-ray diffraction; Filaments; Escherichia coli ER - TY - JOUR T1 - Colicin Biology AN - 19616027; 7339971 AB - Colicins are proteins produced by and toxic for some strains of Escherichia coli. They are produced by strains of E. coli carrying a colicinogenic plasmid that bears the genetic determinants for colicin synthesis, immunity, and release. Insights gained into each fundamental aspect of their biology are presented: their synthesis, which is under SOS regulation; their release into the extracellular medium, which involves the colicin lysis protein; and their uptake mechanisms and modes of action. Colicins are organized into three domains, each one involved in a different step of the process of killing sensitive bacteria. The structures of some colicins are known at the atomic level and are discussed. Colicins exert their lethal action by first binding to specific receptors, which are outer membrane proteins used for the entry of specific nutrients. They are then translocated through the outer membrane and transit through the periplasm by either the Tol or the TonB system. The components of each system are known, and their implication in the functioning of the system is described. Colicins then reach their lethal target and act either by forming a voltage-dependent channel into the inner membrane or by using their endonuclease activity on DNA, rRNA, or tRNA. The mechanisms of inhibition by specific and cognate immunity proteins are presented. Finally, the use of colicins as laboratory or biotechnological tools and their mode of evolution are discussed. JF - Microbiology and Molecular Biology Reviews AU - Cascales, Eric AU - Buchanan, Susan K AU - Duche, Denis AU - Kleanthous, Colin AU - Lloubes, Roland AU - Postle, Kathleen AU - Riley, Margaret AU - Slatin, Stephen AU - Cavard, Daniele AD - Laboratoire d'Ingenierie des Systemes Macromoleculaires, Institut de Biologie Structurale et Microbiologie, Centre National de la Recherche Scientifique, UPR9027, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France. Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892. Department of Biology Area 10, P.O. Box 373, University of York, York YO10 5YW, United Kingdom. 301 Althouse Laboratory, Department of Biochemistry and Molecular Biology, Eberly College of Science, Pennsylvania State University, University Park, Pennsylvania 16802. Department of Biology, University of Massachusetts at Amherst, Amherst, Massachusetts 01003. Department of Physiology and Biophysics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461 Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 158 EP - 229 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 71 IS - 1 SN - 1092-2172, 1092-2172 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - outer membrane proteins KW - tRNA KW - Nutrients KW - Immunity KW - Plasmids KW - rRNA KW - Inner membranes KW - Escherichia coli KW - Colicins KW - DNA KW - Endonuclease KW - periplasm KW - Evolution KW - J 02330:Biochemistry KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19616027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiology+and+Molecular+Biology+Reviews&rft.atitle=Colicin+Biology&rft.au=Cascales%2C+Eric%3BBuchanan%2C+Susan+K%3BDuche%2C+Denis%3BKleanthous%2C+Colin%3BLloubes%2C+Roland%3BPostle%2C+Kathleen%3BRiley%2C+Margaret%3BSlatin%2C+Stephen%3BCavard%2C+Daniele&rft.aulast=Cascales&rft.aufirst=Eric&rft.date=2007-03-01&rft.volume=71&rft.issue=1&rft.spage=158&rft.isbn=&rft.btitle=&rft.title=Microbiology+and+Molecular+Biology+Reviews&rft.issn=10922172&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - rRNA; outer membrane proteins; tRNA; Inner membranes; DNA; Colicins; Nutrients; Immunity; Plasmids; Endonuclease; periplasm; Evolution; Escherichia coli ER - TY - JOUR T1 - Transcript and protein expression profiles of the NCI-60 cancer cell panel: an integromic microarray study AN - 19613700; 7340008 AB - To evaluate the utility of transcript profiling for prediction of protein expression levels, we compared profiles across the NCI-60 cancer cell panel, which represents nine tissues of origin. For that analysis, we present here two new NCI-60 transcript profile data sets (A based on Affymetrix HG-U95 and HG-U133A chips; Affymetrix, Santa Clara, CA) and one new protein profile data set (based on reverse-phase protein lysate arrays). The data sets are available online at http://discover.nci.nih.gov in the CellMiner program package. Using the new transcript data in combination with our previously published cDNA array and Affymetrix HU6800 data sets, we first developed a "consensus set" of transcript profiles based on the four different microarray platforms. Using that set, we found that 65% of the genes showed statistically significant transcript-protein correlation, and the correlations were generally higher than those reported previously for panels of mammalian cells. Using the predictive analysis of microarray nearest shrunken centroid algorithm for functional prediction of tissue of origin, we then found that (a) the consensus mRNA set did better than did data from any of the individual mRNA platforms and (b) the protein data seemed to do somewhat better (P = 0.027) on a gene-for-gene basis in this particular study than did the consensus mRNA data, but both did well. Analysis based on the Gene Ontology showed protein levels of structure-related genes to be well predicted by mRNA levels (mean r = 0.71). Because the transcript-based technologies are more mature and are currently able to assess larger numbers of genes at one time, they continue to be useful, even when the ultimate aim is information about proteins. [Mol Cancer Ther 2007; 6(3):820-32] JF - Molecular Cancer Therapeutics AU - Shankavaram, Uma T AU - Reinhold, William C AU - Nishizuka, Satoshi AU - Major, Sylvia AU - Morita, Daisaku AU - Chary, Krishna K AU - Reimers, Mark A AU - Scherf, Uwe AU - Kahn, Ari AU - Dolginow, Douglas AU - Cossman, Jeffrey AU - Kaldjian, Eric P AU - Scudiero, Dominic A AU - Petricoin, Emanuel AU - Liotta, Lance AU - Lee, Jae K AU - Weinstein, John N AD - Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 820 EP - 832 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 6 IS - 3 SN - 1535-7163, 1535-7163 KW - Biotechnology and Bioengineering Abstracts KW - Mammalian cells KW - Protein arrays KW - Algorithms KW - Statistical analysis KW - Transcription KW - DNA microarrays KW - Cancer KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19613700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cancer+Therapeutics&rft.atitle=Transcript+and+protein+expression+profiles+of+the+NCI-60+cancer+cell+panel%3A+an+integromic+microarray+study&rft.au=Shankavaram%2C+Uma+T%3BReinhold%2C+William+C%3BNishizuka%2C+Satoshi%3BMajor%2C+Sylvia%3BMorita%2C+Daisaku%3BChary%2C+Krishna+K%3BReimers%2C+Mark+A%3BScherf%2C+Uwe%3BKahn%2C+Ari%3BDolginow%2C+Douglas%3BCossman%2C+Jeffrey%3BKaldjian%2C+Eric+P%3BScudiero%2C+Dominic+A%3BPetricoin%2C+Emanuel%3BLiotta%2C+Lance%3BLee%2C+Jae+K%3BWeinstein%2C+John+N&rft.aulast=Shankavaram&rft.aufirst=Uma&rft.date=2007-03-01&rft.volume=6&rft.issue=3&rft.spage=820&rft.isbn=&rft.btitle=&rft.title=Molecular+Cancer+Therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Mammalian cells; Protein arrays; Statistical analysis; Algorithms; Transcription; DNA microarrays; Cancer ER - TY - JOUR T1 - Dietary Fat and Postmenopausal Invasive Breast Cancer in the National Institutes of Health-AARP Diet and Health Study Cohort AN - 19608729; 7316933 AB - BACKGROUND: Although ecologic association and animal studies support a direct effect of dietary fat on the development of breast cancer, results of epidemiologic studies have been inconclusive. METHODS: We prospectively analyzed the association between fat consumption and the incidence of postmenopausal invasive breast cancer in the National Institutes of Health-AARP Diet and Health Study, a US cohort comprising 188 736 postmenopausal women who completed a 124-item food-frequency questionnaire in 1995-1996. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards regression models with adjustment for energy and potential confounding factors. All statistical tests were two-sided. RESULTS: Over an average follow-up of 4.4 years, the cohort yielded 3501 cases of invasive breast cancer. The hazard ratio of breast cancer for the highest (median intake, 40.1% energy from total fat; 434 cases per 100 000 person-years) versus the lowest (median intake, 20.3% energy from total fat; 392 cases per 100 000 person-years) quintile of total fat intake was 1.11 (95% CI = 1.00 to 1.24; P sub(trend) = .017). The corresponding hazard ratio for a twofold increase in percent energy from total fat on the continuous scale was 1.15 (95% CI = 1.05 to 1.26). Positive associations were also found for subtypes of fat (hazard ratio for a twofold increase in percent energy from saturated fat = 1.13; 95% CI = 1.05 to 1.22; from monounsaturated fat, HR = 1.12; 95% CI = 1.03 to 1.21; from polyunsaturated fat, HR = 1.10, 95% CI = 1.01 to 1.20). Correction for measurement error in nutrient intakes, on the basis of a calibration substudy that used two 24-hour dietary recalls, strengthened the associations, yielding an estimated hazard ratio for total fat of 1.32 (95% CI = 1.11 to 1.58). Secondary analyses showed that associations between total, saturated, and monounsaturated fat intakes were confined to women who were not using menopausal hormone therapy at baseline. CONCLUSION: In this large prospective cohort with a wide range of fat intake, dietary fat intake was directly associated with the risk of postmenopausal invasive breast cancer. JF - Journal of the National Cancer Institute AU - Thiebaut, Anne CM AU - Kipnis, Victor AU - Chang, Shih-Chen AU - Subar, Amy F AU - Thompson, Frances E AU - Rosenberg, Philip S AU - Hollenbeck, Albert R AU - Leitzmann, Michael AU - Schatzkin, Arthur AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics (ACMT, SCC, ML, AS), Biometry Research Group, Division of Cancer Prevention (VK), Applied Research Program, Division of Cancer Control and Population Sciences (AFS, FET), Biostatistics Branch, Division of Cancer Epidemiology and Genetics (PSR), National Cancer Institute, Bethesda, MD Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 451 EP - 462 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 6 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Diets KW - post-menopause KW - secondary analysis KW - Breast cancer KW - Hormones KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19608729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Dietary+Fat+and+Postmenopausal+Invasive+Breast+Cancer+in+the+National+Institutes+of+Health-AARP+Diet+and+Health+Study+Cohort&rft.au=Thiebaut%2C+Anne+CM%3BKipnis%2C+Victor%3BChang%2C+Shih-Chen%3BSubar%2C+Amy+F%3BThompson%2C+Frances+E%3BRosenberg%2C+Philip+S%3BHollenbeck%2C+Albert+R%3BLeitzmann%2C+Michael%3BSchatzkin%2C+Arthur&rft.aulast=Thiebaut&rft.aufirst=Anne&rft.date=2007-03-01&rft.volume=99&rft.issue=6&rft.spage=451&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Diets; post-menopause; secondary analysis; Breast cancer; Hormones ER - TY - JOUR T1 - SMotif: a server for structural motifs in proteins AN - 19607478; 7314450 AB - SUMMARY: SMotif is a server that identifies important structural segments or motifs for a given protein structure(s) based on conservation of both sequential as well as important structural features such as solvent inaccessibility, secondary structural content, hydrogen bonding pattern and residue packing. This server also provides three-dimensional orientation patterns of the identified motifs in terms of inter-motif distances and torsion angles. These motifs may form the common core and therefore, can also be employed to design and rationalize protein engineering and folding experiments. AVAILABILITY: SMotif server is available via the URL http://caps.ncbs.res.in/SMotif/index.html. CONTACT: chakrabaail.nih.gov, minicbs.res.in or EPNSugantu.edu.sg Supplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Pugalenthi, Ganesan AU - Suganthan, P N AU - Sowdhamini, R AU - Chakrabarti, Saikat AD - School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798, National Centre for Biological Sciences, Bangalore 560 065, India and National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, USA Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 637 EP - 638 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 23 IS - 5 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Protein folding KW - Protein engineering KW - Hydrogen bonding KW - Solvents KW - Conserved sequence KW - Bioinformatics KW - Packing KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19607478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=SMotif%3A+a+server+for+structural+motifs+in+proteins&rft.au=Pugalenthi%2C+Ganesan%3BSuganthan%2C+P+N%3BSowdhamini%2C+R%3BChakrabarti%2C+Saikat&rft.aulast=Pugalenthi&rft.aufirst=Ganesan&rft.date=2007-03-01&rft.volume=23&rft.issue=5&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Protein engineering; Protein folding; Hydrogen bonding; Solvents; Conserved sequence; Packing; Bioinformatics ER - TY - JOUR T1 - Localization of Cocaine Analog [ super(125)I]RTI 82 Irreversible Binding to Transmembrane Domain 6 of the Dopamine Transporter AN - 19603704; 7316289 AB - The site of cocaine binding on the dopamine transporter (DAT) was investigated using the photoactivatable irreversible cocaine analog [ super(125)I]3 beta -(p-chlorophenyl)tropane-2 beta -carboxylic acid, 4'-azido-3'-iodophenylethyl ester ([ super(125)I]RTI 82). The incorporation site of this compound was mapped to transmembrane domains (TMs) 4-6 using epitope-specific immunoprecipitation of trypsin fragments and further localized using cyanogen bromide (CNBr), which hydrolyzes proteins on the C-terminal side of methionine residues. CNBr hydrolysis of [ super(125)I]RTI 82-labeled rat striatal and expressed human DATs produced fragments of similar to 5-10 kDa consistent with labeling between Met super(271/272) or Met super(290) in TM5 to Met super(370/371) in TM7. To further define the incorporation site, substitution mutations were made that removed endogenous methionines and inserted exogenous methionines in combinations that would generate labeled CNBr fragments of distinct masses depending on the labeling site. The results obtained were consistent with the presence of TM6 but not TMs 4, 5, or 7 in the labeled fragments, with additional support for these conclusions obtained by epitope-specific immunoprecipitation and secondary digestion of CNBr fragments with endoproteinase Lys-C. The final localization of [ super(125)I]RTI 82 incorporation to rat DAT Met super(290)-Lys super(336) and human DAT I291M to R344M provides positive evidence for the proximity of cocaine binding to TM6. Residues in and near DAT TM6 regulate transport and transport-dependent conformational states, and TM6 forms part of the substrate permeation pathway in the homologous Aquifex aeolicus leucine transporter. Cocaine binding near TM6 may thus overlap the dopamine translocation pathway and function to inhibit TM6 structural rearrangements necessary for transport. JF - Journal of Biological Chemistry AU - Vaughan, Roxanne A AU - Sakrikar, Dhananjay S AU - Parnas, MLaura AU - Adkins, Steven AU - Foster, James D AU - Duval, Romain A AU - Lever, John R AU - Kulkarni, Santosh S AU - Hauck-Newman, Amy AD - Department of Biochemistry and Molecular Biology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58203-9037, the Departments of Radiology, and Medical Pharmacology and Physiology, University of Missouri and the Harry S. Truman Veterans Administration Medical Center, Columbia, Missouri 65212, and the Medicinal Chemistry Section, Intramural Research Program, National Institute on Drug Abuse, Bethesda, Maryland 21224 Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 8915 EP - 8925 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 12 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Amino acid substitution KW - Trypsin KW - Immunoprecipitation KW - bromides KW - Esters KW - Transmembrane domains KW - Hydrolysis KW - Methionine KW - Dopamine transporter KW - Aquifex aeolicus KW - Neostriatum KW - Leucine KW - Cocaine KW - Translocation KW - N3 11008:Neurochemistry KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19603704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Localization+of+Cocaine+Analog+%5B+super%28125%29I%5DRTI+82+Irreversible+Binding+to+Transmembrane+Domain+6+of+the+Dopamine+Transporter&rft.au=Vaughan%2C+Roxanne+A%3BSakrikar%2C+Dhananjay+S%3BParnas%2C+MLaura%3BAdkins%2C+Steven%3BFoster%2C+James+D%3BDuval%2C+Romain+A%3BLever%2C+John+R%3BKulkarni%2C+Santosh+S%3BHauck-Newman%2C+Amy&rft.aulast=Vaughan&rft.aufirst=Roxanne&rft.date=2007-03-01&rft.volume=282&rft.issue=12&rft.spage=8915&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Amino acid substitution; Trypsin; Immunoprecipitation; Transmembrane domains; Esters; bromides; Hydrolysis; Methionine; Dopamine transporter; Neostriatum; Leucine; Cocaine; Translocation; Aquifex aeolicus ER - TY - JOUR T1 - Combination Therapy of an Orthotopic Renal Cell Carcinoma Model Using Intratumoral Vector-Mediated Costimulation and Systemic Interleukin-2 AN - 19603652; 7315240 AB - PURPOSE: Interleukin (IL)-2 therapy is currently used for therapy of renal cell carcinoma (RCC). However, it is only effective in approximately 10% to 15% of patients, showing a need for additional therapies. We have previously described a replication-defective fowlpox vector encoding three costimulatory molecules (B7-1, ICAM-1, and LFA-3), designated rF-TRICOM. Here, we show that intratumoral administration of rF-TRICOM in an orthotopic RCC model effectively enhances tumor immunogenicity and reduces tumor burden in mice and the combination of rF-TRICOM and IL-2 is more effective than either therapy alone. Experimental Design: RCC cells were implanted under the capsule of the kidney, and mice were given rF-TRICOM intratumorally 14 days later. We compared the effect of rF-TRICOM, rF-granulocyte macrophage colony-stimulating factor (GM-CSF), and two doses of IL-2 and combinations of the above on antitumor efficacy and survival. Host CD4 super(+) and CD8 super(+) T-cell responses were also evaluated. RESULTS: The results show that (a) systemic IL-2 therapy was moderately effective in the reduction of tumor burden in an orthotopic RCC model; (b) a single intratumoral injection of rF-TRICOM and rF-GM-CSF significantly reduced tumor burden; (c) the addition of systemic IL-2 to intratumoral rF-TRICOM/rF-GM-CSF administration resulted in further reduction of tumor burden, decrease in the incidence of metastasis, and extended survival in tumor-bearing mice above that seen with either treatment alone; and (d) CD8 super(+) T cells played a critical role in the antitumor effect seen with rF-TRICOM/rF-GM-CSF + IL-2 therapy. Finally, the addition of systemic recombinant IL-15 or intratumoral vector-delivered IL-15 to intratumoral rF-TRICOM/rF-GM-CSF administration resulted in substantially more tumor-free mice than either therapy alone. CONCLUSIONS: These studies show that intratumoral administration of rF-TRICOM admixed with rF-GM-CSF is effective at reducing tumor burden in mice and the addition of IL-2 further contributes to this effect. These studies thus form the rationale for combination immunotherapy clinical trials in patients with RCC. JF - Clinical Cancer Research AU - Kudo-Saito, Chie AU - Wansley, Elizabeth K AU - Gruys, MEilene AU - Wiltrout, Robert AU - Schlom, Jeffrey AU - Hodge, James W AD - Authors' Affiliations: Laboratories of Tumor Immunology and Biology and Experimental Immunology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 1936 EP - 1946 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 13 IS - 6 SN - 1078-0432, 1078-0432 KW - Virology & AIDS Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Cell survival KW - Interleukin 2 KW - Fowlpox KW - Immunotherapy KW - Animal models KW - Cell culture KW - Macrophage colony-stimulating factor KW - Clinical trials KW - Metastases KW - CD4 antigen KW - renal cell carcinoma KW - Interleukin 15 KW - intercellular adhesion molecule 1 KW - Lymphocytes T KW - CD58 antigen KW - Granulocyte-macrophage colony-stimulating factor KW - Vectors KW - CD8 antigen KW - Tumors KW - B7-1 antigen KW - Costimulator KW - Immunogenicity KW - Kidney KW - Antitumor activity KW - W 30905:Medical Applications KW - V 22350:Immunology KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19603652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Combination+Therapy+of+an+Orthotopic+Renal+Cell+Carcinoma+Model+Using+Intratumoral+Vector-Mediated+Costimulation+and+Systemic+Interleukin-2&rft.au=Kudo-Saito%2C+Chie%3BWansley%2C+Elizabeth+K%3BGruys%2C+MEilene%3BWiltrout%2C+Robert%3BSchlom%2C+Jeffrey%3BHodge%2C+James+W&rft.aulast=Kudo-Saito&rft.aufirst=Chie&rft.date=2007-03-01&rft.volume=13&rft.issue=6&rft.spage=1936&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell survival; Fowlpox; Interleukin 2; Immunotherapy; Granulocyte-macrophage colony-stimulating factor; Animal models; CD58 antigen; Vectors; Cell culture; Macrophage colony-stimulating factor; Tumors; CD8 antigen; Clinical trials; Metastases; Costimulator; B7-1 antigen; CD4 antigen; Interleukin 15; renal cell carcinoma; Immunogenicity; intercellular adhesion molecule 1; Kidney; Lymphocytes T; Antitumor activity ER - TY - JOUR T1 - The effect of haem in red and processed meat on the endogenous formation of N-nitroso compounds in the upper gastrointestinal tract AN - 19603280; 7314939 AB - Red and processed meat (PM) consumption increases the risk of large bowel cancer and it has been demonstrated that haem in red meat (RM) stimulates the endogenous production of N-nitroso compounds (NOCs) within the human intestine. To investigate whether N-nitrosation occurs in the upper gastrointestinal tract, 27 ileostomists were fed diets containing no meat, or 240 g RM or 240 g PM in a randomly assigned crossover intervention design carried out in a volunteer suite. Endogenous NOC were assessed as apparent total N-nitroso compounds (ATNC) in the ileostomy output. ATNC concentration in the diets was 22 mu g ATNC/kg (RM) and 37 mu g ATNC/kg (PM), and 9 mu g ATNC/kg in the no meat diet. Levels significantly increased to 1175 mu g ATNC/kg SEM = 226 mu g ATNC/kg) following the RM (P = 0.001) and 1832 mu g ATNC/kg (SEM = 294 mu g ATNC/kg) following PM (P < 0.001) compared to the no meat diet (283 mu g ATNC/kg, SEM = 74 mu g ATNC/kg). ATNC concentrations in the ileal output were equivalent to those measured in faeces in similarly designed feeding studies. Supplementation with either 1 g ascorbic acid or 400 IU alpha -tocopherol had no effect on the concentration of ATNC detected in the ileal output. In in vitro experiments, N-nitrosomorpholine (NMor) was formed in the presence of nitrosated haemoglobin, at pH 6.8 but not in the absence of nitrosated haemoglobin. These findings demonstrate that haem may facilitate the formation of NOC in the absence of colonic flora in the upper human gastrointestinal tract. JF - Carcinogenesis AU - Lunn, J C AU - Kuhnle, G AU - Mai, V AU - Frankenfeld, C AU - Shuker, DEG AU - Glen, R C AU - Goodman, J M AU - Pollock, JRA AU - Bingham, SA AD - MRC Dunn Human Nutrition Unit, MRC/Wellcome Trust Building Cambridge, CB2 2XY, UK. Department of Epidemiology and Preventive Medicine, University of Maryland Medical School Baltimore, MD 21201, USA. Division of Cancer Epidemiology and Genetics, National Cancer Institute Bethesda, MD, USA. The Unilever Centre for Molecular Sciences Informatics, University of Cambridge Cambridge, UK. Department of Chemistry, The Open University Milton Keynes, UK. Pollock and Pool Ltd, Woodley Reading, Berkshire, RG5 4DX, UK Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 685 EP - 690 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 28 IS - 3 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts KW - Diets KW - Cancer KW - Supplementation KW - Ascorbic acid KW - Hemoglobin KW - Meat KW - Vitamin E KW - N-Nitroso compounds KW - N-Nitrosomorpholine KW - Digestive tract KW - Carcinogenesis KW - Intestine KW - Ileostomy KW - Feces KW - pH effects KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19603280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=The+effect+of+haem+in+red+and+processed+meat+on+the+endogenous+formation+of+N-nitroso+compounds+in+the+upper+gastrointestinal+tract&rft.au=Lunn%2C+J+C%3BKuhnle%2C+G%3BMai%2C+V%3BFrankenfeld%2C+C%3BShuker%2C+DEG%3BGlen%2C+R+C%3BGoodman%2C+J+M%3BPollock%2C+JRA%3BBingham%2C+SA&rft.aulast=Lunn&rft.aufirst=J&rft.date=2007-03-01&rft.volume=28&rft.issue=3&rft.spage=685&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Diets; Supplementation; Cancer; Ascorbic acid; Meat; Hemoglobin; N-Nitroso compounds; Vitamin E; Digestive tract; N-Nitrosomorpholine; Carcinogenesis; Intestine; Ileostomy; Feces; pH effects ER - TY - JOUR T1 - Genotypic Analysis of Invasive Streptococcus pneumoniae from Mali, Africa, by Semiautomated Repetitive-Element PCR and Pulsed-Field Gel Electrophoresis AN - 19602732; 7316504 AB - As part of a large, ongoing study of invasive infections in pediatric patients in Bamako, Mali, 106 cases of invasive pneumococcal disease were identified from June 2002 to July 2003 (J. D. Campbell et al., Pediatr. Infect. Dis. J. 23:642-649, 2004). Of the 12 serotypes present, the majority of isolates were not contained in PCV7 (the 7-valent pneumococcal conjugate vaccine), including 1 isolate that was serotype 1, 12 isolates that were serotype 2, 58 isolates that were serotype 5, 7 isolates that were serotype 7F, and 1 isolate that was serotype 12F. To determine whether clonal dissemination of the predominant serotypes had taken place, genotyping was performed on 100 S. pneumoniae isolates by using two methods: pulsed-field gel electrophoresis (PFGE) of SmaI-digested genomic DNA, and the Bacterial Barcodes repetitive-element PCR (rep-PCR) method. Criteria for delineating rep-PCR genotypes were established such that isolates of different serotypes were generally not grouped together. The two methods were equally discriminatory within a given pneumococcal serotype. PFGE separated the isolates into 15 genotypes and 7 subtypes; rep-PCR separated isolates into 15 genotypes and 6 subtypes. Using either method, isolates within serotypes 2, 5, and 7 formed three large, separate clusters containing 1 genotype each. Both methods further distinguished related subtypes within serotypes 2 and 5. Interestingly, one of the PFGE subtypes of serotype 5 is indistinguishable from the Columbia super(5)-19 clone circulating in Latin America since 1994. The data support that serotypes 2 and 5 were likely to be the result of dissemination of particular clones, some of which are responsible for invasive disease over a broad population range. JF - Journal of Clinical Microbiology AU - Harrington, S M AU - Stock, F AU - Kominski, AL AU - Campbell, J D AU - Hormazabal, J C AU - Livio, S AU - Rao, L AU - Kotloff, K L AU - Sow, SO AU - Murray, PR AD - Department of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland. Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland. Microbiology Department, Instituto de Salud Publica, Santiago, Chile. Center for Vaccine Development, Bamako, Mali Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 707 EP - 714 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 45 IS - 3 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Streptococcus pneumoniae KW - Serotypes KW - Pediatrics KW - Genotyping KW - Pulsed-field gel electrophoresis KW - Polymerase chain reaction KW - Genotypes KW - genomics KW - Vaccines KW - Infection KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19602732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Genotypic+Analysis+of+Invasive+Streptococcus+pneumoniae+from+Mali%2C+Africa%2C+by+Semiautomated+Repetitive-Element+PCR+and+Pulsed-Field+Gel+Electrophoresis&rft.au=Harrington%2C+S+M%3BStock%2C+F%3BKominski%2C+AL%3BCampbell%2C+J+D%3BHormazabal%2C+J+C%3BLivio%2C+S%3BRao%2C+L%3BKotloff%2C+K+L%3BSow%2C+SO%3BMurray%2C+PR&rft.aulast=Harrington&rft.aufirst=S&rft.date=2007-03-01&rft.volume=45&rft.issue=3&rft.spage=707&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Serotypes; Pediatrics; Genotyping; Pulsed-field gel electrophoresis; Polymerase chain reaction; Vaccines; genomics; Genotypes; Infection; Streptococcus pneumoniae ER - TY - JOUR T1 - A Target Cell-Specific Activatable Fluorescence Probe for In vivo Molecular Imaging of Cancer Based on a Self-Quenched Avidin-Rhodamine Conjugate AN - 19597762; 7314901 AB - A target cell-specific activation strategy for improved molecular imaging of peritoneal implants has been proposed, in which fluorophores are activated only in living targeted cells. A current example of an activatable fluorophore is one that is normally self-quenched by attachment to a peptide backbone but which can be activated by specific proteases that degrade the peptide resulting in "dequenching." In this study, an alternate fluorescence activation strategy is proposed whereby self-quenching avidin-rhodamine X, which has affinity for lectin on cancer cells, is activated after endocytosis and degradation within the lysosome. Using this approach in a mouse model of peritoneal ovarian metastases, we document target-specific molecular imaging of submillimeter cancer nodules with minimal contamination by background signal. Cellular internalization of receptor-ligand pairs with subsequent activation of fluorescence via dequenching provides a generalizable and highly sensitive method of detecting cancer microfoci in vivo and has practical implications for assisting surgical and endoscopic procedures. [Cancer Res 2007; 67(6):2791-9] JF - Cancer Research AU - Hama, Yukihiro AU - Urano, Yasuteru AU - Koyama, Yoshinori AU - Kamiya, Mako AU - Bernardo, Marcelino AU - Paik, Ronald S AU - Shin, In Soo AU - Paik, Chang H AU - Choyke, Peter L AU - Kobayashi, Hisataka AD - Molecular Imaging Program, Center for Cancer Research, National Cancer Institute Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 2791 EP - 2799 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 67 IS - 6 SN - 0008-5472, 0008-5472 KW - Biotechnology and Bioengineering Abstracts KW - Molecular modelling KW - Fluorescence KW - Contamination KW - Peritoneum KW - Animal models KW - Lectins KW - fluorophores KW - imaging KW - Nodules KW - Cancer KW - Metastases KW - Endocytosis KW - Fluorescent indicators KW - Proteinase KW - Lysosomes KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19597762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=A+Target+Cell-Specific+Activatable+Fluorescence+Probe+for+In+vivo+Molecular+Imaging+of+Cancer+Based+on+a+Self-Quenched+Avidin-Rhodamine+Conjugate&rft.au=Hama%2C+Yukihiro%3BUrano%2C+Yasuteru%3BKoyama%2C+Yoshinori%3BKamiya%2C+Mako%3BBernardo%2C+Marcelino%3BPaik%2C+Ronald+S%3BShin%2C+In+Soo%3BPaik%2C+Chang+H%3BChoyke%2C+Peter+L%3BKobayashi%2C+Hisataka&rft.aulast=Hama&rft.aufirst=Yukihiro&rft.date=2007-03-01&rft.volume=67&rft.issue=6&rft.spage=2791&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Fluorescence; Contamination; Peritoneum; Animal models; Lectins; fluorophores; imaging; Cancer; Nodules; Metastases; Endocytosis; Fluorescent indicators; Proteinase; Lysosomes ER - TY - JOUR T1 - Cooperation of Toll-like receptor signals in innate immune defence AN - 19591541; 7312046 AB - The mechanisms by which the recognition of Toll-like receptor (TLR) ligands leads to host immunity remain poorly defined. It is now thought that to induce an effective immune response, microorganisms must stimulate complex sets of pattern-recognition receptors, both within and outside of the TLR family. The combined activation of these different receptors can result in complementary, synergistic or antagonistic effects that modulate innate and adaptive immunity. Therefore, a complete understanding of the role of TLRs in host resistance to infection requires 'decoding' of these multiple receptor interactions. This Review highlights recent advances in the newly emerging field of TLR cooperation and discusses their implications for the development of adjuvants and immunotherapies. JF - Nature Reviews: Immunology AU - Trinchieri, Giorgio AU - Sher, Alan AD - Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Building 560, Room 31-93, Frederick, Maryland 21702-1201, USA. Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 179 EP - 190 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 7 IS - 3 SN - 1474-1733, 1474-1733 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Reviews KW - Immunotherapy KW - Cooperation KW - Immune system KW - Microorganisms KW - Immunity KW - Adjuvants KW - Immune response KW - Infection KW - Toll-like receptors KW - Cooperativity KW - A 01490:Miscellaneous KW - F 06960:Molecular Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19591541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Immunology&rft.atitle=Cooperation+of+Toll-like+receptor+signals+in+innate+immune+defence&rft.au=Trinchieri%2C+Giorgio%3BSher%2C+Alan&rft.aulast=Trinchieri&rft.aufirst=Giorgio&rft.date=2007-03-01&rft.volume=7&rft.issue=3&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Immunology&rft.issn=14741733&rft_id=info:doi/10.1038%2Fnri2038 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Immune system; Cooperation; Immunotherapy; Reviews; Microorganisms; Immune response; Adjuvants; Immunity; Infection; Toll-like receptors; Cooperativity DO - http://dx.doi.org/10.1038/nri2038 ER - TY - JOUR T1 - Lytic Metastases in Thoracolumbar Spine: Computer-aided Detection at CT-Preliminary Study AN - 19580653; 7297295 AB - PURPOSE: To evaluate the sensitivity of a computer-aided detection (CAD) system for detection of lytic thoracolumbar spinal lesions at body CT, with results of manual lesion segmentation as the reference standard. MATERIALS AND METHODS: The study was HIPAA compliant and institutional review board approved; the institutional review board waived the need for informed consent. The CAD system segments the spine on CT images and searches for detections that match size, shape, location, and attenuation criteria. To reduce false-positive findings, 16 features for each detection were computed and fed to a classifier trained with manually segmented lesions. The data set consisted of CT studies of 50 patients (30 men, 20 women; range, 18-82 years; mean, 54.8 years) with 28 lesions. Studies were assigned to either a training (29 studies) or testing (21 studies) set. Sensitivities and false-positive rates (FPRs) for training and testing sets were calculated for these lesions, which were probable lytic metastases with areas 0.8 cm super(2) or greater. RESULTS: Training set sensitivity was 0.83 (10 of 12; 95% confidence interval: 0.51, 0.97), with an FPR of 7.4 per patient. Test set sensitivity was 0.94 (15 of 16; 95% confidence interval: 0.68, 1.00), with an FPR of 4.5 per patient. There was no significant difference between the CAD sensitivities of the training and test sets (P = .56). Of three false-negative findings, two were due to incomplete segmentation of the vertebral pedicle, and the third was rejected by the classifier. False-positive detections were most often attributable to veins that connect the basivertebral vein with the anterior venous plexus (106 [34%] of 310) and to low-attenuating disks (83 [27%] of 310). CONCLUSION: This CAD system successfully identified probable lytic metastases in the thoracolumbar spine and generalized well to an independent testing set. Supplemental material: http://radiology.rsnajnls.org/cgi/content/full/242/3/811/DC1 [copy ] RSNA, 2007 JF - Radiology AU - O'Connor, Stacy D AU - Yao, Jianhua AU - Summers, Ronald M AD - Diagnostic Radiology Department, Clinical Center, National Institutes of Health (NIH), Bldg 10, Room 1C351, 10 Center Dr, MSC 1182, Bethesda, MD 20892-1182 Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 811 EP - 816 PB - Radiological Society of North America, 820 Jorie Blvd. Oak Brook Illinois 60523-2251 USA VL - 242 IS - 3 SN - 0033-8419, 0033-8419 KW - Biotechnology and Bioengineering Abstracts KW - Metastases KW - Veins KW - Segmentation KW - Image processing KW - Vertebrae KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19580653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Lytic+Metastases+in+Thoracolumbar+Spine%3A+Computer-aided+Detection+at+CT-Preliminary+Study&rft.au=O%27Connor%2C+Stacy+D%3BYao%2C+Jianhua%3BSummers%2C+Ronald+M&rft.aulast=O%27Connor&rft.aufirst=Stacy&rft.date=2007-03-01&rft.volume=242&rft.issue=3&rft.spage=811&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Metastases; Veins; Segmentation; Image processing; Vertebrae ER - TY - JOUR T1 - Orphan Nuclear Receptor Constitutive Active/Androstane Receptor-Mediated Alterations in DNA Methylation during Phenobarbital Promotion of Liver Tumorigenesis AN - 19579348; 7297710 AB - Altered DNA methylation is an epigenetic mechanism that plays a key role in the carcinogenesis process, and the nongenotoxic rodent hepatocarcinogen phenobarbital (PB) alters the methylation status of DNA in mouse liver. The constitutive active/androstane nuclear receptor (CAR) mediates half of the PB-induced hepatic gene expression changes and it is essential for liver tumor promotion in PB-treated mice. Here, a technique involving methylation-sensitive restriction digestion, arbitrarily primed PCR, and capillary electrophoresis was utilized to detect PB-induced regions of altered DNA methylation (RAMs) in CAR wildtype (WT) mice that are sensitive to promotion by PB and resistant CAR knockout (KO) mice. The CAR WT mice developed preneoplastic lesions after 23 weeks of PB treatment (precancerous) and liver tumors after 32 weeks, while the CAR KO mice did not develop tumors (Y. Yamamoto, et al., 2004, Cancer Res. 64, 7197-7200). Our goal was to discern those RAMs which are playing important roles in tumor formation by comparing the RAMs that form in sensitive and resistant groups of mice. Using this novel approach, 42 unique RAMs were identified in the precancerous as compared to the CAR KO, 23-week PB-treated tissue. Of these 42 RAMs, 14 carried forward to the tumor tissue, and additionally, 104 total unique RAMs were observed in the tumor tissue. These results indicate that there are unique RAMs occurring in the sensitive CAR WT mice and that a portion of these are seen in both the precancerous and tumor tissue. We hypothesize that these unique RAMs may be facilitating the tumorigenesis process, and these data support the view that DNA methylation plays a causative role in PB-induced tumorigenesis. JF - Toxicological Sciences AU - Phillips, Jennifer M AU - Yamamoto, Yukio AU - Negishi, Masahiko AU - Maronpot, Robert R AU - Goodman, Jay I AD - Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824. Reproductive and Developmental Toxicology and. Experimental Pathology, NIEHS, NIH, Research Triangle Park, North Carolina 27709. Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824 Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 72 EP - 82 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 96 IS - 1 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Phenobarbital KW - Nuclear receptors KW - Tumorigenesis KW - Cancer KW - Gene expression KW - orphan nuclear receptors KW - epigenetics KW - Carcinogenesis KW - Liver KW - DNA methylation KW - capillary electrophoresis KW - Polymerase chain reaction KW - X 24310:Pharmaceuticals KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19579348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Orphan+Nuclear+Receptor+Constitutive+Active%2FAndrostane+Receptor-Mediated+Alterations+in+DNA+Methylation+during+Phenobarbital+Promotion+of+Liver+Tumorigenesis&rft.au=Phillips%2C+Jennifer+M%3BYamamoto%2C+Yukio%3BNegishi%2C+Masahiko%3BMaronpot%2C+Robert+R%3BGoodman%2C+Jay+I&rft.aulast=Phillips&rft.aufirst=Jennifer&rft.date=2007-03-01&rft.volume=96&rft.issue=1&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gene expression; Phenobarbital; orphan nuclear receptors; epigenetics; Nuclear receptors; Carcinogenesis; Tumorigenesis; capillary electrophoresis; DNA methylation; Liver; Polymerase chain reaction; Cancer ER - TY - JOUR T1 - Changes in Paracrine Interleukin-2 Requirement, CCR7 Expression, Frequency, and Cytokine Secretion of Human Immunodeficiency Virus-Specific CD4 super(+) T Cells Are a Consequence of Antigen Load AN - 19574747; 7289782 AB - Virus-specific CD4 super(+) T-cell responses are thought to be required for the induction and maintenance of many effective CD8 super(+) T-cell and B-cell immune responses in experimental animals and humans. Although the presence of human immunodeficiency virus (HIV)-specific CD4 super(+) T cells has been documented in patients at all stages of HIV infection, many fundamental questions regarding their frequency and function remain. A 10-color, 12-parameter flow cytometric panel was utilized to examine the frequency, memory phenotype (CD27, CCR7, and CD45RA), and cytokine production (interleukin-2 [IL-2], gamma interferon, and tumor necrosis factor alpha) of CD4 super(+) T cells specific for HIV antigens as well as for adenovirus, Epstein-Barr virus (EBV), influenza H1N1 virus, influenza H3N2 virus, cytomegalovirus, varicella-zoster virus (VZV), and tetanus toxoid in normal controls, long-term nonprogressors (LTNP), and HIV-infected patients with progressive disease on or off therapy. The HIV-specific CD4 super(+) T-cell responses in LTNP and patients on therapy were similar in frequency, phenotype, and cytokine production to responses directed against adenovirus, EBV, influenza virus, and VZV. HIV-specific CD4 super(+) T cells from patients off antiretroviral therapy demonstrated a shift towards a CCR7 super(-) CD45RA super(-) phenotype and a reduced percentage of IL-2-producing cells. The alterations in cytokine production during HIV viremia were found to be intrinsic to the HIV-specific CD4 super(+) T cells and caused a requirement for IL-2 supplied exogenously for proliferation to occur. These observations suggest that many previously described changes in HIV-specific CD4 super(+) T-cell function and phenotype are a consequence of high levels of antigen in viremic patients. In addition, defects in function and phenotype of HIV-specific CD4 super(+) T cells are not readily discernible in the context of antiretroviral therapy but rather are similar to responses to other viruses. JF - Journal of Virology AU - Tilton, John C AU - Luskin, Marlise R AU - Johnson, Alison J AU - Manion, Maura AU - Hallahan, Claire W AU - Metcalf, Julia A AU - McLaughlin, Mary AU - Davey, Richard TJr AU - Connors, Mark AD - Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 2713 EP - 2725 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 81 IS - 6 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Virology & AIDS Abstracts KW - gamma -Interferon KW - Interleukin 2 KW - Immunodeficiency KW - Immunological memory KW - Toxoids KW - Infection KW - Tetanus KW - Cytomegalovirus KW - Flow cytometry KW - Influenza KW - Epstein-Barr virus KW - CC chemokine receptors KW - CD4 antigen KW - CD27 antigen KW - Lymphocytes T KW - Lymphocytes B KW - antiretroviral therapy KW - Paracrine signalling KW - Adenovirus KW - Memory cells KW - CD8 antigen KW - Influenza virus KW - CD45RA antigen KW - Human immunodeficiency virus KW - Varicella-zoster virus KW - Tumor necrosis factor- alpha KW - Viremia KW - Vaccines KW - Cell proliferation KW - CCR7 protein KW - V 22360:AIDS and HIV KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19574747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Changes+in+Paracrine+Interleukin-2+Requirement%2C+CCR7+Expression%2C+Frequency%2C+and+Cytokine+Secretion+of+Human+Immunodeficiency+Virus-Specific+CD4+super%28%2B%29+T+Cells+Are+a+Consequence+of+Antigen+Load&rft.au=Tilton%2C+John+C%3BLuskin%2C+Marlise+R%3BJohnson%2C+Alison+J%3BManion%2C+Maura%3BHallahan%2C+Claire+W%3BMetcalf%2C+Julia+A%3BMcLaughlin%2C+Mary%3BDavey%2C+Richard+TJr%3BConnors%2C+Mark&rft.aulast=Tilton&rft.aufirst=John&rft.date=2007-03-01&rft.volume=81&rft.issue=6&rft.spage=2713&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Interleukin 2; Lymphocytes B; Paracrine signalling; antiretroviral therapy; Immunological memory; Immunodeficiency; Memory cells; Toxoids; CD8 antigen; Tetanus; Infection; Influenza; Flow cytometry; CD4 antigen; CC chemokine receptors; CD45RA antigen; CD27 antigen; Lymphocytes T; Vaccines; Viremia; Tumor necrosis factor- alpha; Cell proliferation; CCR7 protein; Epstein-Barr virus; Influenza virus; Human immunodeficiency virus; Varicella-zoster virus; Adenovirus; Cytomegalovirus ER - TY - JOUR T1 - The Novel Transcription Factor SgrR Coordinates the Response to Glucose-Phosphate Stress AN - 19569713; 7288264 AB - SgrR is the first characterized member of a family of bacterial transcription factors containing an N-terminal DNA binding domain and a C-terminal solute binding domain. Previously, we reported genetic evidence that SgrR activates the divergently transcribed gene sgrS, which encodes a small RNA required for recovery from glucose-phosphate stress. In this study, we examined the regulation of sgrR expression and found that SgrR negatively autoregulates its own transcription in the presence and absence of stress. An SgrR binding site in the sgrR-sgrS intergenic region is required in vivo for both SgrR-dependent activation of sgrS and autorepression of sgrR. Purified SgrR binds specifically to sgrS promoter DNA in vitro; a mutation in the site required for in vivo activation and autorepression abrogates in vitro SgrR binding. A plasmid library screen identified clones that alter expression of a P sub(sgrS)-lacZ fusion; some act by titrating endogenous SgrR. The yfdZ gene, encoding a putative aminotransferase, was identified in this screen; the yfdZ promoter contains an SgrR binding site, and transcriptional fusions indicate that yfdZ is activated by SgrR. Clones containing mlc, which encodes a glucose-specific repressor protein, also downregulate P sub(sgrS)-lacZ. The mlc clones do not appear to titrate the SgrR protein, indicating that Mlc affects sgrS expression by an alternative mechanism. JF - Journal of Bacteriology AU - Vanderpool, Carin K AU - Gottesman, Susan AD - Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892 Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 2238 EP - 2248 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 189 IS - 6 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Promoters KW - Solutes KW - RNA KW - Transcription factors KW - DNA KW - Stress KW - Plasmids KW - Repressors KW - Mutation KW - J 02310:Genetics & Taxonomy KW - N 14825:Gene Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19569713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=The+Novel+Transcription+Factor+SgrR+Coordinates+the+Response+to+Glucose-Phosphate+Stress&rft.au=Vanderpool%2C+Carin+K%3BGottesman%2C+Susan&rft.aulast=Vanderpool&rft.aufirst=Carin&rft.date=2007-03-01&rft.volume=189&rft.issue=6&rft.spage=2238&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Solutes; Promoters; RNA; Transcription factors; DNA; Stress; Plasmids; Mutation; Repressors ER - TY - JOUR T1 - New Tuberculosis Drugs in Development AN - 19487987; 8516156 AB - Over the past 50 years, no new drug classes have been introduced to treat tuberculosis. Tuberculosis (TB) kills nearly two million people a year mainly in the poorest communities in the developing world. It afflicts millions more. About one third of the world's population is silently infected with TB that may erupt into disease with increased age or suppression of the immune system. Nearly nine million new active cases develop every year. The World Health Organization (WHO) declared the disease a global emergency as long ago as 1993. Although huge efforts in public health control have reduced the disease burden within most established market economies, in Africa and Asia the epidemic continues to accelerate, particularly fueled by the HIV epidemic. Furthermore, resistance to the standard drugs isoniazid and rifampicin is increasing worldwide. Since the 1990s, mycobacteria have emerged with resistance patterns rendering all currently available antibiotics ineffectual. The pharmaceutical industry has mostly abandoned TB drug development due to perceived non-profitable consumer market and the diminishing number of companies engaged in anti-infective research. The public sector and infectious disease researchers have responded to advance fundamental science and to create new chemical entities as early drug candidates. With support from research funding agencies, philanthropic donors, and the STOP-TB Partnership, new chemical tools and new approaches to effectively implement TB control programs are evolving. Advanced preclinical development and strategies for Phase III clinical trials remain gap areas that will require additional engagement from all sectors. JF - Current Topics in Medicinal Chemistry AU - Laughon, Barbara E AD - Division of AIDS, NIAID,National Institutes of Health, 6700-B Rockledge Drive Room 5108,Bethesda, MD 20892-7624, USA. Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 463 EP - 473 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 7 IS - 6 SN - 1568-0266, 1568-0266 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Tuberculosis KW - mycobacterium KW - drug development KW - medicinal chemistry KW - public-private partnerships KW - antibiotics KW - multidrug resistance KW - latency KW - acquired immunodeficiency syndrome: complications KW - antitubercular agents KW - Age KW - Epidemics KW - Mycobacterium KW - Immune system KW - Control programs KW - Antibiotics KW - Drug development KW - Development KW - Clinical trials KW - Public health KW - Rifampin KW - Infectious diseases KW - Human immunodeficiency virus KW - Reviews KW - Pharmaceuticals KW - Consumers KW - Drugs KW - Isoniazid KW - W 30915:Pharmaceuticals & Vaccines KW - F 06910:Microorganisms & Parasites KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19487987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Topics+in+Medicinal+Chemistry&rft.atitle=New+Tuberculosis+Drugs+in+Development&rft.au=Laughon%2C+Barbara+E&rft.aulast=Laughon&rft.aufirst=Barbara&rft.date=2007-03-01&rft.volume=7&rft.issue=6&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=Current+Topics+in+Medicinal+Chemistry&rft.issn=15680266&rft_id=info:doi/10.2174%2F156802607780059736 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Age; Epidemics; Control programs; Immune system; Drug development; Antibiotics; Development; Clinical trials; Public health; Rifampin; Infectious diseases; Reviews; Pharmaceuticals; Tuberculosis; Consumers; Drugs; Isoniazid; Mycobacterium; Human immunodeficiency virus DO - http://dx.doi.org/10.2174/156802607780059736 ER - TY - JOUR T1 - Synthesis of O-prenylated and O-geranylated derivatives of 5-benzylidene2,4-thiazolidinediones and evaluation of their free radical scavenging activity as well as effect on some phase II antioxidant/detoxifying enzymes AN - 19377500; 7891111 AB - A series of 5-arylidene-2, 4-thiazolidinediones and its geranyloxy or prenyloxy derivative were synthesized and studied for their radical scavenging activity using 1, 1 -diphenyl-2-picrylhydrazyl (DPPH) assay. Their comparable scavenging activities were expressed as IC50 value. Compounds 2c, 2d, 4d, and 6a showed appreciable radical scavenging activities. The vanillin based thiazolidinedione compound 2c displayed highest activity comparable to that of alpha -tocopherol. But in vivo, compound 6a showed better results in inducing phase II detoxifying/antioxidative enzyme. JF - Bioorganic and Medicinal Chemistry Letters AU - Hossain, SU AU - Bhattacharya, S AD - Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700 026, West Bengal, India Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 1149 EP - 1154 VL - 17 IS - 5 SN - 0960-894X, 0960-894X KW - Biotechnology and Bioengineering Abstracts KW - Vitamin E KW - Antioxidants KW - Free radicals KW - Enzymes KW - vanillin KW - thiazolidinediones KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19377500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Synthesis+of+O-prenylated+and+O-geranylated+derivatives+of+5-benzylidene2%2C4-thiazolidinediones+and+evaluation+of+their+free+radical+scavenging+activity+as+well+as+effect+on+some+phase+II+antioxidant%2Fdetoxifying+enzymes&rft.au=Hossain%2C+SU%3BBhattacharya%2C+S&rft.aulast=Hossain&rft.aufirst=SU&rft.date=2007-03-01&rft.volume=17&rft.issue=5&rft.spage=1149&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmol.2006.12.040 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Vitamin E; Antioxidants; Free radicals; Enzymes; thiazolidinediones; vanillin DO - http://dx.doi.org/10.1016/j.bmol.2006.12.040 ER - TY - CPAPER T1 - Patterns of Antihypertensive Therapy in the Jackson Heart Study Cohort T2 - 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in Association with the Council on Nutrition, Physical Activity, and Metabolism AN - 40547076; 4530132 JF - 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in Association with the Council on Nutrition, Physical Activity, and Metabolism AU - Walker, Evelyn R AU - Wyatt, Sharon B AU - Wofford, Marion AU - Nelson, Cheryl AU - Akylbekova, Ermekgul AU - Wilson, Gregory AU - Keahy, Wanda AU - Taylor, Herman A AU - Jones, Dan Y1 - 2007/02/28/ PY - 2007 DA - 2007 Feb 28 KW - Antihypertensives KW - Heart KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40547076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=SMotif%3A+a+server+for+structural+motifs+in+proteins&rft.au=Pugalenthi%2C+Ganesan%3BSuganthan%2C+P+N%3BSowdhamini%2C+R%3BChakrabarti%2C+Saikat&rft.aulast=Pugalenthi&rft.aufirst=Ganesan&rft.date=2007-03-01&rft.volume=23&rft.issue=5&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ L2 - http://www.americanheart.org/presenter.jhtml?identifier=3038389 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genome-wide Association with Adiposity-related Traits: The Framingham Heart Study 100K Project T2 - 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in Association with the Council on Nutrition, Physical Activity, and Metabolism AN - 40546892; 4530060 JF - 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in Association with the Council on Nutrition, Physical Activity, and Metabolism AU - Fox, Caroline S AU - Heard-Costa, Nancy AU - Cupples, L Adrienne AU - Dupuis, Josee AU - Vasan, Ramachandran S AU - Atwood, Larry D Y1 - 2007/02/28/ PY - 2007 DA - 2007 Feb 28 KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40546892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention+in+Association+with+the+Council+on+Nutrition%2C+Physical+Activity%2C+and+Metabolism&rft.atitle=Genome-wide+Association+with+Adiposity-related+Traits%3A+The+Framingham+Heart+Study+100K+Project&rft.au=Fox%2C+Caroline+S%3BHeard-Costa%2C+Nancy%3BCupples%2C+L+Adrienne%3BDupuis%2C+Josee%3BVasan%2C+Ramachandran+S%3BAtwood%2C+Larry+D&rft.aulast=Fox&rft.aufirst=Caroline&rft.date=2007-02-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention+in+Association+with+the+Council+on+Nutrition%2C+Physical+Activity%2C+and+Metabolism&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/presenter.jhtml?identifier=3038389 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Subcutaneous and Visceral Adipose Tissue and their Association with Coronary and Aortic Artery Calcification: The Framingham Heart Study T2 - 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in Association with the Council on Nutrition, Physical Activity, and Metabolism AN - 40546054; 4530059 JF - 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in Association with the Council on Nutrition, Physical Activity, and Metabolism AU - Fox, Caroline S AU - Hwang, Shih-Jen AU - Massaro, Joseph M AU - Pou, Karla M AU - Larson, Martin G AU - Hoffmann, Udo AU - O'Donnell, Christopher J Y1 - 2007/02/28/ PY - 2007 DA - 2007 Feb 28 KW - Adipose tissues KW - Adipose tissue KW - Calcification (ectopic) KW - Arteries KW - Heart KW - Aorta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40546054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention+in+Association+with+the+Council+on+Nutrition%2C+Physical+Activity%2C+and+Metabolism&rft.atitle=Subcutaneous+and+Visceral+Adipose+Tissue+and+their+Association+with+Coronary+and+Aortic+Artery+Calcification%3A+The+Framingham+Heart+Study&rft.au=Fox%2C+Caroline+S%3BHwang%2C+Shih-Jen%3BMassaro%2C+Joseph+M%3BPou%2C+Karla+M%3BLarson%2C+Martin+G%3BHoffmann%2C+Udo%3BO%27Donnell%2C+Christopher+J&rft.aulast=Fox&rft.aufirst=Caroline&rft.date=2007-02-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention+in+Association+with+the+Council+on+Nutrition%2C+Physical+Activity%2C+and+Metabolism&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/presenter.jhtml?identifier=3038389 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Validated Parental History of Premature Cardiovascular Disease as a Risk Factor for Coronary Artery Calcification in the Framingham Third-generation Cohort T2 - 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in Association with the Council on Nutrition, Physical Activity, and Metabolism AN - 40545074; 4530356 JF - 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in Association with the Council on Nutrition, Physical Activity, and Metabolism AU - Parikh, Nisha I AU - Hwang, Shih-Jen AU - Larson, Martin G AU - Fox, Caroline S AU - Manders, Emily S AU - Murabito, Joanne AU - Massaro, Joseph M AU - Hoffmann, Udo AU - O'Donnell, Christopher J Y1 - 2007/02/28/ PY - 2007 DA - 2007 Feb 28 KW - Historical account KW - Cardiovascular diseases KW - Calcification (ectopic) KW - Coronary artery KW - Risk factors KW - Circulatory system KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40545074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention+in+Association+with+the+Council+on+Nutrition%2C+Physical+Activity%2C+and+Metabolism&rft.atitle=Validated+Parental+History+of+Premature+Cardiovascular+Disease+as+a+Risk+Factor+for+Coronary+Artery+Calcification+in+the+Framingham+Third-generation+Cohort&rft.au=Parikh%2C+Nisha+I%3BHwang%2C+Shih-Jen%3BLarson%2C+Martin+G%3BFox%2C+Caroline+S%3BManders%2C+Emily+S%3BMurabito%2C+Joanne%3BMassaro%2C+Joseph+M%3BHoffmann%2C+Udo%3BO%27Donnell%2C+Christopher+J&rft.aulast=Parikh&rft.aufirst=Nisha&rft.date=2007-02-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention+in+Association+with+the+Council+on+Nutrition%2C+Physical+Activity%2C+and+Metabolism&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/presenter.jhtml?identifier=3038389 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Deciphering Genetic Determinants for Subclinical Atherosclerosis in Multiple Arterial Beds: Genome-Wide Association Study in the NHLBI Framingham Heart Study T2 - 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in Association with the Council on Nutrition, Physical Activity, and Metabolism AN - 40543726; 4530314 JF - 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in Association with the Council on Nutrition, Physical Activity, and Metabolism AU - O'Donnell, Christopher J AU - Demissie, Serkalem AU - Murabito, Joanne M AU - Fox, Caroline S AU - Hwang, Shih-Jen AU - Wang, Thomas J AU - Cupples, L Adrienne Y1 - 2007/02/28/ PY - 2007 DA - 2007 Feb 28 KW - Arteriosclerosis KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40543726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention+in+Association+with+the+Council+on+Nutrition%2C+Physical+Activity%2C+and+Metabolism&rft.atitle=Deciphering+Genetic+Determinants+for+Subclinical+Atherosclerosis+in+Multiple+Arterial+Beds%3A+Genome-Wide+Association+Study+in+the+NHLBI+Framingham+Heart+Study&rft.au=O%27Donnell%2C+Christopher+J%3BDemissie%2C+Serkalem%3BMurabito%2C+Joanne+M%3BFox%2C+Caroline+S%3BHwang%2C+Shih-Jen%3BWang%2C+Thomas+J%3BCupples%2C+L+Adrienne&rft.aulast=O%27Donnell&rft.aufirst=Christopher&rft.date=2007-02-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention+in+Association+with+the+Council+on+Nutrition%2C+Physical+Activity%2C+and+Metabolism&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/presenter.jhtml?identifier=3038389 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma. AN - 70280794; 17360629 AB - Brefeldin A-inhibited guanine nucleotide-exchange proteins (GEPs) BIG1 and BIG2 activate ADP-ribosylation factor (ARF) GTPases, which are required for vesicular trafficking. Both molecules contain one or more sites for binding protein kinase A, i.e., A kinase-anchoring protein (AKAP) sequences. Elevation of cell cAMP caused PKA-catalyzed phosphorylation and nuclear accumulation of BIG1 but not BIG2. We then asked whether BIG1 phosphorylation altered its GEP activity. Incubation of BIG1 or BIG2 with PKA catalytic subunits and ATP resulted in retardation of their electrophoretic migration, consistent with PKA phosphorylation. Okadaic acid inhibits many protein phosphatases, including protein phosphatase 1 (PP1) and PP2A, that can reverse PKA-catalyzed phosphorylation. Incubation of HepG2 cells with okadaic acid caused concentration-dependent accumulation of presumably phosphorylated BIG1 and BIG2 with decreased mobility, which was increased by subsequent incubation in vitro with specific recombinant phosphatases, PP1gamma > PP2A >> PP1alpha. For assays of GEP activity, BIG1 and BIG2 were immunoprecipitated from cells that had been depleted, respectively, of BIG2 and BIG1 by using specific siRNA. GEP activity of each was significantly decreased after incubation with recombinant PKA plus ATP and restored by incubation with PP1gamma. In agreement with a role for PP1gamma in regulation of BIG, endogenous PP1gamma, but not PP1alpha or beta, was immunoprecipitated with BIG1 or BIG2 from microsomal fractions. All observations are consistent with the effects of BIG1 and BIG2 phosphorylation on vesicular trafficking, via alterations in ARF activation and regulatory roles for cAMP, PKA, and PP1gamma in ARF activation by BIG1 and BIG2. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Kuroda, Fuminobu AU - Moss, Joel AU - Vaughan, Martha AD - Pulmonary-Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1434, USA. Y1 - 2007/02/27/ PY - 2007 DA - 2007 Feb 27 SP - 3201 EP - 3206 VL - 104 IS - 9 SN - 0027-8424, 0027-8424 KW - ARFGEF1 protein, human KW - 0 KW - Guanine Nucleotide Exchange Factors KW - Vesicular Transport Proteins KW - Okadaic Acid KW - 1W21G5Q4N2 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Cyclic AMP-Dependent Protein Kinases KW - EC 2.7.11.11 KW - Phosphoprotein Phosphatases KW - EC 3.1.3.16 KW - Protein Phosphatase 1 KW - ADP-Ribosylation Factors KW - EC 3.6.5.2 KW - Index Medicus KW - Microscopy, Fluorescence KW - Blotting, Western KW - Phosphorylation KW - Humans KW - Adenosine Triphosphate -- metabolism KW - Immunoprecipitation KW - Okadaic Acid -- metabolism KW - Cell Line, Tumor KW - Cyclic AMP-Dependent Protein Kinases -- metabolism KW - ADP-Ribosylation Factors -- metabolism KW - Guanine Nucleotide Exchange Factors -- metabolism KW - Phosphoprotein Phosphatases -- metabolism KW - Vesicular Transport Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70280794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Regulation+of+brefeldin+A-inhibited+guanine+nucleotide-exchange+protein+1+%28BIG1%29+and+BIG2+activity+via+PKA+and+protein+phosphatase+1gamma.&rft.au=Kuroda%2C+Fuminobu%3BMoss%2C+Joel%3BVaughan%2C+Martha&rft.aulast=Kuroda&rft.aufirst=Fuminobu&rft.date=2007-02-27&rft.volume=104&rft.issue=9&rft.spage=3201&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-13 N1 - Date created - 2007-03-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Trends Cell Biol. 2000 Feb;10(2):60-7 [10652516] Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2683-8 [16467138] J Clin Invest. 2000 Sep;106(5):R31-8 [10974026] J Cell Sci. 2002 Jan 15;115(Pt 2):241-56 [11839776] Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1627-32 [12571360] J Biol Chem. 2003 May 23;278(21):18817-23 [12657641] Physiol Rev. 2004 Jan;84(1):1-39 [14715909] Mol Biol Cell. 2004 Apr;15(4):1487-505 [14742722] EMBO J. 2004 Jul 21;23(14):2811-20 [15229649] Curr Biol. 2004 Aug 24;14(16):1436-50 [15324660] Annu Rev Biochem. 1989;58:453-508 [2549856] Annu Rev Biochem. 1990;59:971-1005 [2165385] Crit Rev Oncol Hematol. 1995 Nov;21(1-3):33-61 [8822496] Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12856-60 [8917509] Nature. 1996 Dec 5;384(6608):481-4 [8945478] J Biol Chem. 1997 Feb 14;272(7):3993-8 [9020105] EMBO J. 1997 Apr 15;16(8):1876-87 [9155014] Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2635-40 [16477018] Trends Biochem Sci. 2006 Jun;31(6):316-23 [16690317] J Cell Sci. 2006 Sep 15;119(Pt 18):3764-75 [16926194] Mol Cell. 2006 Nov 3;24(3):383-95 [17081989] J Biol Chem. 1997 May 16;272(20):12881-4 [9190362] Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4204-8 [9539714] J Biol Chem. 1998 Aug 21;273(34):21431-4 [9705267] J Biol Chem. 1998 Dec 25;273(52):35048-55 [9857038] J Biol Chem. 1999 Apr 30;274(18):12308-15 [10212200] J Biol Chem. 1999 Oct 8;274(41):29057-62 [10506157] Cell Cycle. 2005 Feb;4(2):323-9 [15655353] Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2567-72 [10716990] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Requirements for DNA hairpin formation by RAG1/2. AN - 70272558; 17307873 AB - The rearrangement of antigen receptor genes is initiated by double-strand breaks catalyzed by the RAG1/2 complex at the junctions of recombination signal sequences and coding segments. As with some "cut-and-paste" transposases, such as Tn5 and Hermes, a DNA hairpin is formed at one end of the break via a nicked intermediate. By using abasic DNA substrates, we show that different base positions are important for the two steps of cleavage. Removal of one base in the coding flank enhances hairpin formation, bypassing a requirement for a paired complex of two signal sequences. Rescue by abasic substrates is consistent with a base-flip mechanism seen in the crystal structure of the Tn5 postcleavage complex and may mimic the DNA changes on paired complex formation. We have searched for a tryptophan residue in RAG1 that would be the functional equivalent of W298 in Tn5, which stabilizes the DNA interaction by stacking the flipped base on the indole ring. A W956A mutation in RAG1 had an inhibitory effect on both nicking and hairpin stages that could be rescued by abasic substrates. W956 is therefore a likely candidate for interacting with this base during hairpin formation. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Grundy, Gabrielle J AU - Hesse, Joanne E AU - Gellert, Martin AD - Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 5, Room 241, Bethesda, MD 20892, USA. Y1 - 2007/02/27/ PY - 2007 DA - 2007 Feb 27 SP - 3078 EP - 3083 VL - 104 IS - 9 SN - 0027-8424, 0027-8424 KW - DNA-Binding Proteins KW - 0 KW - Homeodomain Proteins KW - Nuclear Proteins KW - RAG2 protein, human KW - RAG-1 protein KW - 128559-51-3 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Electrophoretic Mobility Shift Assay KW - Mutation -- genetics KW - DNA Breaks, Single-Stranded KW - Mutagenesis KW - Nuclear Proteins -- genetics KW - Homeodomain Proteins -- genetics KW - DNA -- metabolism KW - Homeodomain Proteins -- metabolism KW - DNA-Binding Proteins -- genetics KW - Nuclear Proteins -- metabolism KW - Nucleic Acid Conformation KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70272558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Requirements+for+DNA+hairpin+formation+by+RAG1%2F2.&rft.au=Grundy%2C+Gabrielle+J%3BHesse%2C+Joanne+E%3BGellert%2C+Martin&rft.aulast=Grundy&rft.aufirst=Gabrielle&rft.date=2007-02-27&rft.volume=104&rft.issue=9&rft.spage=3078&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-13 N1 - Date created - 2007-03-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 2001 Mar;21(6):2038-47 [11238939] Nature. 1998 Aug 20;394(6695):744-51 [9723614] EMBO J. 2001 Jun 1;20(11):2931-42 [11387226] Genetics. 2001 Jul;158(3):949-57 [11454746] Mol Cell Biol. 2002 Jan;22(1):69-77 [11739723] J Biol Chem. 2002 Mar 29;277(13):11284-91 [11805107] Mol Cell Biol. 2002 May;22(10):3460-73 [11971977] Annu Rev Biochem. 2002;71:101-32 [12045092] Mol Cell Biol. 1999 Dec;19(12):8094-102 [10567535] Cell. 1998 Aug 21;94(4):463-70 [9727489] Annu Rev Biochem. 1998;67:181-98 [9759487] Cell. 1998 Oct 2;95(1):125-34 [9778253] Mol Cell Biol. 1999 May;19(5):3788-97 [10207102] Nature. 2004 Dec 23;432(7020):995-1001 [15616554] Nat Struct Mol Biol. 2005 Aug;12(8):715-21 [16041385] Mol Cell. 2005 Oct 7;20(1):143-54 [16209952] Nat Immunol. 2005 Dec;6(12):1272-9 [16286921] Nat Struct Mol Biol. 2006 Nov;13(11):1010-5 [17028591] Genes Dev. 1999 Dec 1;13(23):3059-69 [10601032] Genes Dev. 1999 Dec 1;13(23):3070-80 [10601033] Mol Cell. 2000 Jan;5(1):97-107 [10678172] Science. 2000 Jul 7;289(5476):77-85 [10884228] Cell. 2000 Jun 9;101(6):625-33 [10892649] Mol Cell Biol. 2001 Jan;21(2):459-66 [11134334] EMBO J. 2002 Aug 1;21(15):4162-71 [12145216] Mol Cell Biol. 2002 Oct;22(20):7217-25 [12242298] Mol Cell Biol. 2002 Nov;22(22):7790-801 [12391148] EMBO J. 2003 Apr 15;22(8):1931-8 [12682025] Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13768-73 [15365172] Nature. 1983 Apr 14;302(5909):575-81 [6300689] Genes Dev. 1993 Jul;7(7B):1459-69 [8330743] Nucleic Acids Res. 1993 Dec 11;21(24):5644-50 [8284210] Genes Dev. 1995 Sep 1;9(17):2193-9 [7657170] Cell. 1995 Nov 3;83(3):387-95 [8521468] Nature. 1996 Mar 7;380(6569):85-8 [8598914] Cell. 1996 Apr 5;85(1):107-13 [8620529] EMBO J. 1996 Jun 17;15(12):3197-206 [8670820] Mol Cell Biol. 1996 Oct;16(10):5683-90 [8816481] J Exp Med. 1997 Jun 2;185(11):2025-32 [9166431] EMBO J. 1997 May 15;16(10):2665-70 [9184213] Genetics. 1998 Jun;149(2):693-701 [9611184] Mol Cell Biol. 1998 Aug;18(8):4679-88 [9671478] Immunity. 1998 Jul;9(1):115-25 [9697841] Nat Struct Biol. 2001 Apr;8(4):302-7 [11276247] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Control of the Secretomes of Bacillus Cereus Group Members by the PlcR/PapR System T2 - 5th Annual Meeting of the American Society for Microbiology Biodefense and Emerging Diseases Research AN - 40623827; 4566565 JF - 5th Annual Meeting of the American Society for Microbiology Biodefense and Emerging Diseases Research AU - Pomerantsev, A P AU - Pomerantseva, O M AU - Leppla, S H AU - Baillie, L W Y1 - 2007/02/27/ PY - 2007 DA - 2007 Feb 27 KW - Secretome KW - Phospholipase C KW - Bacillus cereus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40623827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+C%3A+Embryo+Today%3A+Reviews&rft.atitle=Human+stem+cells%2C+chromatin%2C+and+tissue+engineering%3A+Boosting+relevancy+in+developmental+toxicity+testing&rft.au=Cho%2C+Elizabeth%3BLi%2C+Wan-Ju&rft.aulast=Cho&rft.aufirst=Elizabeth&rft.date=2007-03-01&rft.volume=81&rft.issue=1&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+C%3A+Embryo+Today%3A+Reviews&rft.issn=1542975X&rft_id=info:doi/10.1002%2Fbdrc.20087 L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFE7DAF5E%2DA0D2%2D4977% 2D8C64%2D57DACAE944D7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Virus Microarray T2 - 5th Annual Meeting of the American Society for Microbiology Biodefense and Emerging Diseases Research AN - 40622923; 4566586 DE: JF - 5th Annual Meeting of the American Society for Microbiology Biodefense and Emerging Diseases Research AU - Baptista, C S AU - Wu, X. AU - Shannon, E AU - Stewart, C AU - Nordstrom, H AU - Lundkvist, A AU - Munroe, D J Y1 - 2007/02/27/ PY - 2007 DA - 2007 Feb 27 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40622923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+American+Society+for+Microbiology+Biodefense+and+Emerging+Diseases+Research&rft.atitle=Virus+Microarray&rft.au=Baptista%2C+C+S%3BWu%2C+X.%3BShannon%2C+E%3BStewart%2C+C%3BNordstrom%2C+H%3BLundkvist%2C+A%3BMunroe%2C+D+J&rft.aulast=Baptista&rft.aufirst=C&rft.date=2007-02-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+American+Society+for+Microbiology+Biodefense+and+Emerging+Diseases+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFE7DAF5E%2DA0D2%2D4977% 2D8C64%2D57DACAE944D7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Candidate Q Fever Diagnostic Antigens Revealed by Immunoscreening a Coxiella burnetii Protein Microarray T2 - 5th Annual Meeting of the American Society for Microbiology Biodefense and Emerging Diseases Research AN - 40622749; 4566545 JF - 5th Annual Meeting of the American Society for Microbiology Biodefense and Emerging Diseases Research AU - Beare, P A AU - Cockrell, D C AU - Barbian, K D AU - Porcella, S F AU - Pablo, J AU - Chen, C AU - Samuel, J E AU - Felgner, P L AU - Heinzen, R A Y1 - 2007/02/27/ PY - 2007 DA - 2007 Feb 27 KW - Protein arrays KW - Q fever KW - Antigens KW - Coxiella burnetii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40622749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+American+Society+for+Microbiology+Biodefense+and+Emerging+Diseases+Research&rft.atitle=Candidate+Q+Fever+Diagnostic+Antigens+Revealed+by+Immunoscreening+a+Coxiella+burnetii+Protein+Microarray&rft.au=Beare%2C+P+A%3BCockrell%2C+D+C%3BBarbian%2C+K+D%3BPorcella%2C+S+F%3BPablo%2C+J%3BChen%2C+C%3BSamuel%2C+J+E%3BFelgner%2C+P+L%3BHeinzen%2C+R+A&rft.aulast=Beare&rft.aufirst=P&rft.date=2007-02-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+American+Society+for+Microbiology+Biodefense+and+Emerging+Diseases+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFE7DAF5E%2DA0D2%2D4977% 2D8C64%2D57DACAE944D7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Blood Pressure Increases with Norepinephrine Infusion Improved Survival with Lipopolysaccharide (LPS) but not Anthrax Lethal Toxin (LeTx) Challenge in Rats T2 - 5th Annual Meeting of the American Society for Microbiology Biodefense and Emerging Diseases Research AN - 40622601; 4566593 JF - 5th Annual Meeting of the American Society for Microbiology Biodefense and Emerging Diseases Research AU - Li, Y. AU - Cui, X AU - Su, J. AU - Sherer, K AU - Leppla, S AU - Moayeri, M AU - Kenyon, N AU - Scher, D AU - Fitz, Y AU - Eichacker, P Q Y1 - 2007/02/27/ PY - 2007 DA - 2007 Feb 27 KW - Anthrax lethal toxin KW - Survival KW - Rats KW - Lipopolysaccharides KW - Blood pressure KW - Norepinephrine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40622601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+biology+%26+therapy&rft.atitle=Benefits+of+the+combination+of+thalidomide+plus+cyclophosphamide+in+hormone+refractory+prostate+cancer+patients.&rft.au=Al-Chalabi%2C+Tania%3BFigg%2C+William+D&rft.aulast=Al-Chalabi&rft.aufirst=Tania&rft.date=2007-03-01&rft.volume=6&rft.issue=3&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=Cancer+biology+%26+therapy&rft.issn=15384047&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFE7DAF5E%2DA0D2%2D4977% 2D8C64%2D57DACAE944D7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selection of Anthrax Toxin Protective Antigen Variants that Discriminate between the Cellular Receptors TEM8 and CMG2 and Achieve Targeting of Tumor Cells T2 - 5th Annual Meeting of the American Society for Microbiology Biodefense and Emerging Diseases Research AN - 40620881; 4566552 JF - 5th Annual Meeting of the American Society for Microbiology Biodefense and Emerging Diseases Research AU - Chen, K AU - Lu, S. AU - Bankston, L A AU - Liddington, R C AU - Leppla, S H Y1 - 2007/02/27/ PY - 2007 DA - 2007 Feb 27 KW - Anthrax KW - Toxins KW - Tumor cells KW - Protective antigen KW - Tumors KW - Antigens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40620881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Environmental+and+behavioral+factors+and+the+risk+of+non-Hodgkin+lymphoma.&rft.au=Hartge%2C+Patricia%3BSmith%2C+Martyn+T&rft.aulast=Hartge&rft.aufirst=Patricia&rft.date=2007-03-01&rft.volume=16&rft.issue=3&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFE7DAF5E%2DA0D2%2D4977% 2D8C64%2D57DACAE944D7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Method to Study Pathogenesis of Tick-Borne Flavivirus Infection in Tick Larvae. T2 - 5th Annual Meeting of the American Society for Microbiology Biodefense and Emerging Diseases Research AN - 40620848; 4566549 JF - 5th Annual Meeting of the American Society for Microbiology Biodefense and Emerging Diseases Research AU - Mitzel, D N AU - Wolfinbarger, J M AU - Best, S M AU - Bloom, M E Y1 - 2007/02/27/ PY - 2007 DA - 2007 Feb 27 KW - Infection KW - Larvae KW - Flavivirus KW - Ixodidae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40620848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+American+Society+for+Microbiology+Biodefense+and+Emerging+Diseases+Research&rft.atitle=A+Novel+Method+to+Study+Pathogenesis+of+Tick-Borne+Flavivirus+Infection+in+Tick+Larvae.&rft.au=Mitzel%2C+D+N%3BWolfinbarger%2C+J+M%3BBest%2C+S+M%3BBloom%2C+M+E&rft.aulast=Mitzel&rft.aufirst=D&rft.date=2007-02-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+American+Society+for+Microbiology+Biodefense+and+Emerging+Diseases+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFE7DAF5E%2DA0D2%2D4977% 2D8C64%2D57DACAE944D7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Investigating the "Steric Gate" of Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase by Targeted Insertion of Unnatural Amino Acids AN - 19794224; 7730242 AB - To investigate how structural changes in the amino acid side chain affect nucleotide substrate selection in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT), a variety of non-natural tyrosine analogues were substituted for Tyr115 of p66 RT. RT variants containing meta-Tyr, nor-Tyr, aminomethyl-Phe, and 1- and 2-naphthyl-Tyr were produced in an Escherichia coli coupled transcription/translation system. Mutant p66 subunits were reconstituted with wild-type (WT) p51 RT and purified by affinity chromatography. Each modified enzyme retained DNA polymerase activity following mis procedure. Aminomethyl-Phe115 RT incorporated dCTP more efficiently than the WT and was resistant to the chain terminator (-)- beta -2',3'-dideoxy-3'-thiacytidine triphosphate (3TCTP) when examined in a steady-state fidelity assay. However, 2-naphthyl-Tyr115 RT inefficiently incorporated dCTP at low concentrations and was kinetically slower with all dCTP analogues tested. Models of RT containing these side chains suggest that the aminomethyl-Phe115 substitution provides new hydrogen bonds through the minor groove to the incoming dNTP and the template residue of the terminal base pair. These hydrogen bonds likely contribute to the increased efficiency of dCTP incorporation. In contrast, models of HIV-1 RT containing 2-naphthyl-Tyr115 reveal significant steric clashes with Pro157 of the p66 palm subdomain, necessitating rearrangement of the active site. JF - Biochemistry (Washington) AU - Klarmann, G J AU - Eisenhauer, B M AU - Zhang, Y AU - Gotte, M AU - Pata, J D AU - Chatterjee, D K AU - Hecht, S M AU - Le Grice, SFJ AD - HIV Drug Resistance Program, National Cancer Institute-Frederick, Frederick, Maryland 21702, USA Y1 - 2007/02/27/ PY - 2007 DA - 2007 Feb 27 SP - 2118 EP - 2126 VL - 46 IS - 8 SN - 0006-2960, 0006-2960 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts KW - Translation KW - Amino acids KW - Tyrosine KW - Enzymes KW - Transcription KW - Nucleotides KW - Models KW - Affinity chromatography KW - Fidelity KW - Insertion KW - Hydrogen bonding KW - DNA-directed DNA polymerase KW - Human immunodeficiency virus 1 KW - Escherichia coli KW - RNA-directed DNA polymerase KW - Base pairs KW - Amino acid sequence KW - J 02310:Genetics & Taxonomy KW - V 22360:AIDS and HIV KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19794224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Investigating+the+%22Steric+Gate%22+of+Human+Immunodeficiency+Virus+Type+1+%28HIV-1%29+Reverse+Transcriptase+by+Targeted+Insertion+of+Unnatural+Amino+Acids&rft.au=Klarmann%2C+G+J%3BEisenhauer%2C+B+M%3BZhang%2C+Y%3BGotte%2C+M%3BPata%2C+J+D%3BChatterjee%2C+D+K%3BHecht%2C+S+M%3BLe+Grice%2C+SFJ&rft.aulast=Klarmann&rft.aufirst=G&rft.date=2007-02-27&rft.volume=46&rft.issue=8&rft.spage=2118&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi061772w LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Translation; Amino acids; Transcription; Enzymes; Tyrosine; Nucleotides; Models; Affinity chromatography; Fidelity; Hydrogen bonding; Insertion; DNA-directed DNA polymerase; RNA-directed DNA polymerase; Amino acid sequence; Base pairs; Human immunodeficiency virus 1; Escherichia coli DO - http://dx.doi.org/10.1021/bi061772w ER - TY - CPAPER T1 - An Evaluation of the Influence of a Weir Built Cross the Tongkong River to Take Subsurface Flow on the Groundwater Quality and Aquaculture Animal Health T2 - 2007 Aquaculture: Science for Sustainable Aquaculture (AQUACULTURE 2007) AN - 40657484; 4576343 JF - 2007 Aquaculture: Science for Sustainable Aquaculture (AQUACULTURE 2007) AU - Sun, Peter Lin Y1 - 2007/02/26/ PY - 2007 DA - 2007 Feb 26 KW - Aquifers KW - Ground water KW - Rivers KW - Weirs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40657484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Aquaculture%3A+Science+for+Sustainable+Aquaculture+%28AQUACULTURE+2007%29&rft.atitle=An+Evaluation+of+the+Influence+of+a+Weir+Built+Cross+the+Tongkong+River+to+Take+Subsurface+Flow+on+the+Groundwater+Quality+and+Aquaculture+Animal+Health&rft.au=Sun%2C+Peter+Lin&rft.aulast=Sun&rft.aufirst=Peter&rft.date=2007-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Aquaculture%3A+Science+for+Sustainable+Aquaculture+%28AQUACULTURE+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.was.org/meetings/SessionsByDay.asp?MeetingCode=AQ2007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Targeted therapy for cancer stem cells: the patched pathway and ABC transporters AN - 21305234; 11935314 AB - Data from certain leukemias as well as brain and breast cancer indicate that there is a small population of tumor cells with 'stem cell' characteristics and the capacity for self-renewal. The self-renewing cells have many of the properties of normal stem cells and have been termed 'cancer stem cells'. These cancer stem cells make up as few as 1% of the cells in a tumor, making them difficult to detect and study. Like normal stem cells, cancer stem cells have a number of properties permitting them to survive traditional cancer chemotherapy and radiation therapy. These cells express high levels of ATP-binding cassette (ABC) drug transporters, providing for a level of resistance; are relatively quiescent; have higher levels of DNA repair and a lowered ability to enter apoptosis. Combined cancer therapy approaches targeting the cancer stem cells and the non-stem cells may be developed with increased efficacy. Efforts to target the Hedgehog/Patched pathway, critical to embryonic growth and differentiation, and the ABCG2 drug efflux transporter will be presented.Oncogene (2007) 26, 1357-1360. doi:10.1038/sj.onc.1210200 JF - Oncogene AU - Lou, H AU - Dean, M AD - 1 National Cancer Institute-Frederick, Frederick, MD, USA Y1 - 2007/02/26/ PY - 2007 DA - 2007 Feb 26 SP - 1357 EP - 1360 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 26 IS - 9 SN - 0950-9232, 0950-9232 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Oncogenes & Growth Factors Abstracts KW - Apoptosis KW - Data processing KW - ABC transporter KW - Chemotherapy KW - Brain KW - Tumors KW - DNA repair KW - Tumor cells KW - Differentiation KW - Leukemia KW - Stem cells KW - Breast cancer KW - Embryos KW - Patched protein KW - W 30940:Products KW - G 07730:Development & Cell Cycle KW - B 26640:Cell Cycle & DNA Repair UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21305234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Targeted+therapy+for+cancer+stem+cells%3A+the+patched+pathway+and+ABC+transporters&rft.au=Lou%2C+H%3BDean%2C+M&rft.aulast=Lou&rft.aufirst=H&rft.date=2007-02-26&rft.volume=26&rft.issue=9&rft.spage=1357&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/10.1038%2Fsj.onc.1210200 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Data processing; Apoptosis; ABC transporter; Chemotherapy; Brain; Tumors; DNA repair; Tumor cells; Leukemia; Differentiation; Stem cells; Breast cancer; Embryos; Patched protein DO - http://dx.doi.org/10.1038/sj.onc.1210200 ER - TY - CPAPER T1 - Neural Circuitry of Addiction in Humans T2 - 2007 Keystone Symposia on Neurobiology of Addiction (C3) AN - 40522446; 4517149 JF - 2007 Keystone Symposia on Neurobiology of Addiction (C3) AU - Volkow, Nora D Y1 - 2007/02/25/ PY - 2007 DA - 2007 Feb 25 KW - Addiction KW - Neural networks KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40522446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reading+Improvement&rft.atitle=Developing+Preservice+Teachers%3A+A+Self-Study+of+Instructor+Scaffolding&rft.au=Kindle%2C+Karen+J.%3BSchmidt%2C+Cynthia+M.&rft.aulast=Kindle&rft.aufirst=Karen&rft.date=2013-01-01&rft.volume=50&rft.issue=3&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Reading+Improvement&rft.issn=00340510&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 2&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetics of Human Addictions T2 - 2007 Keystone Symposia on Neurobiology of Addiction (C3) AN - 40521840; 4517151 JF - 2007 Keystone Symposia on Neurobiology of Addiction (C3) AU - Goldman, David Y1 - 2007/02/25/ PY - 2007 DA - 2007 Feb 25 KW - Genetics KW - Addiction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40521840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Educational+Research&rft.atitle=The+Most+Important+Thing%3A+Students+with+Reading+and+Writing+Difficulties+Talk+about+Their+Experiences+of+Teachers%27+Treatment+and+Guidance&rft.au=Nielsen%2C+Cecilia&rft.aulast=Nielsen&rft.aufirst=Cecilia&rft.date=2011-01-01&rft.volume=55&rft.issue=5&rft.spage=551&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Journal+of+Educational+Research&rft.issn=00313831&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 2&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relapse to Food Seeking: Recent Findings T2 - 2007 Keystone Symposia on Neurobiology of Addiction (C3) AN - 40519285; 4517111 JF - 2007 Keystone Symposia on Neurobiology of Addiction (C3) AU - Shaham, Yavin Y1 - 2007/02/25/ PY - 2007 DA - 2007 Feb 25 KW - Food KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40519285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Neurobiology+of+Addiction+%28C3%29&rft.atitle=Relapse+to+Food+Seeking%3A+Recent+Findings&rft.au=Shaham%2C+Yavin&rft.aulast=Shaham&rft.aufirst=Yavin&rft.date=2007-02-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Neurobiology+of+Addiction+%28C3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 2&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cbl-Dependent Internalization of TCR-Induced, LAT-Nucleated Signaling Complexes T2 - 2007 Keystone Symposia on Imaging Immune Responses (J7) AN - 40518892; 4517022 JF - 2007 Keystone Symposia on Imaging Immune Responses (J7) AU - Barr, Valarie A Y1 - 2007/02/25/ PY - 2007 DA - 2007 Feb 25 KW - Signal transduction KW - T-cell receptor KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40518892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Imaging+Immune+Responses+%28J7%29&rft.atitle=Cbl-Dependent+Internalization+of+TCR-Induced%2C+LAT-Nucleated+Signaling+Complexes&rft.au=Barr%2C+Valarie+A&rft.aulast=Barr&rft.aufirst=Valarie&rft.date=2007-02-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Imaging+Immune+Responses+%28J7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 0&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Directed Cell-Cell Interactions in the Development of Adaptive Immunity T2 - 2007 Keystone Symposia on Imaging Immune Responses (J7) AN - 40518679; 4516991 JF - 2007 Keystone Symposia on Imaging Immune Responses (J7) AU - Germain, Ronald N Y1 - 2007/02/25/ PY - 2007 DA - 2007 Feb 25 KW - Cell interactions KW - Immunity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40518679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Imaging+Immune+Responses+%28J7%29&rft.atitle=Directed+Cell-Cell+Interactions+in+the+Development+of+Adaptive+Immunity&rft.au=Germain%2C+Ronald+N&rft.aulast=Germain&rft.aufirst=Ronald&rft.date=2007-02-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Imaging+Immune+Responses+%28J7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 0&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Imaging the B-Cell Receptor Signaling in the Immunological Synapse T2 - 2007 Keystone Symposia on Imaging Immune Responses (J7) AN - 40518520; 4517020 JF - 2007 Keystone Symposia on Imaging Immune Responses (J7) AU - Tolar, Pavel Y1 - 2007/02/25/ PY - 2007 DA - 2007 Feb 25 KW - Signal transduction KW - Immunological synapses KW - Imaging techniques KW - B-cell receptor KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40518520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Imaging+Immune+Responses+%28J7%29&rft.atitle=Imaging+the+B-Cell+Receptor+Signaling+in+the+Immunological+Synapse&rft.au=Tolar%2C+Pavel&rft.aulast=Tolar&rft.aufirst=Pavel&rft.date=2007-02-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Imaging+Immune+Responses+%28J7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 0&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of B Cell Motility in Lymph Nodes T2 - 2007 Keystone Symposia on Imaging Immune Responses (J7) AN - 40518443; 4517002 JF - 2007 Keystone Symposia on Imaging Immune Responses (J7) AU - Kehrl, John H Y1 - 2007/02/25/ PY - 2007 DA - 2007 Feb 25 KW - Lymphocytes B KW - Lymph nodes KW - Cell migration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40518443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Imaging+Immune+Responses+%28J7%29&rft.atitle=Regulation+of+B+Cell+Motility+in+Lymph+Nodes&rft.au=Kehrl%2C+John+H&rft.aulast=Kehrl&rft.aufirst=John&rft.date=2007-02-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Imaging+Immune+Responses+%28J7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 0&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Simultaneous clustering of gene expression data with clinical chemistry and pathological evaluations reveals phenotypic prototypes. AN - 70357465; 17408499 AB - Commonly employed clustering methods for analysis of gene expression data do not directly incorporate phenotypic data about the samples. Furthermore, clustering of samples with known phenotypes is typically performed in an informal fashion. The inability of clustering algorithms to incorporate biological data in the grouping process can limit proper interpretation of the data and its underlying biology. We present a more formal approach, the modk-prototypes algorithm, for clustering biological samples based on simultaneously considering microarray gene expression data and classes of known phenotypic variables such as clinical chemistry evaluations and histopathologic observations. The strategy involves constructing an objective function with the sum of the squared Euclidean distances for numeric microarray and clinical chemistry data and simple matching for histopathology categorical values in order to measure dissimilarity of the samples. Separate weighting terms are used for microarray, clinical chemistry and histopathology measurements to control the influence of each data domain on the clustering of the samples. The dynamic validity index for numeric data was modified with a category utility measure for determining the number of clusters in the data sets. A cluster's prototype, formed from the mean of the values for numeric features and the mode of the categorical values of all the samples in the group, is representative of the phenotype of the cluster members. The approach is shown to work well with a simulated mixed data set and two real data examples containing numeric and categorical data types. One from a heart disease study and another from acetaminophen (an analgesic) exposure in rat liver that causes centrilobular necrosis. The modk-prototypes algorithm partitioned the simulated data into clusters with samples in their respective class group and the heart disease samples into two groups (sick and buff denoting samples having pain type representative of angina and non-angina respectively) with an accuracy of 79%. This is on par with, or better than, the assignment accuracy of the heart disease samples by several well-known and successful clustering algorithms. Following modk-prototypes clustering of the acetaminophen-exposed samples, informative genes from the cluster prototypes were identified that are descriptive of, and phenotypically anchored to, levels of necrosis of the centrilobular region of the rat liver. The biological processes cell growth and/or maintenance, amine metabolism, and stress response were shown to discern between no and moderate levels of acetaminophen-induced centrilobular necrosis. The use of well-known and traditional measurements directly in the clustering provides some guarantee that the resulting clusters will be meaningfully interpretable. JF - BMC systems biology AU - Bushel, Pierre R AU - Wolfinger, Russell D AU - Gibson, Greg AD - National Center for Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. bushel@niehs.nih.gov Y1 - 2007/02/23/ PY - 2007 DA - 2007 Feb 23 SP - 15 VL - 1 KW - Acetaminophen KW - 362O9ITL9D KW - Index Medicus KW - Rats KW - Phenotype KW - Animals KW - Necrosis KW - Liver -- pathology KW - Liver -- drug effects KW - Humans KW - Heart Diseases -- genetics KW - Heart Diseases -- blood KW - Disease Models, Animal KW - Heart Diseases -- pathology KW - Acetaminophen -- toxicity KW - Gene Expression Profiling -- statistics & numerical data KW - Clinical Chemistry Tests -- statistics & numerical data KW - Algorithms KW - Data Interpretation, Statistical KW - Cluster Analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70357465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+systems+biology&rft.atitle=Simultaneous+clustering+of+gene+expression+data+with+clinical+chemistry+and+pathological+evaluations+reveals+phenotypic+prototypes.&rft.au=Bushel%2C+Pierre+R%3BWolfinger%2C+Russell+D%3BGibson%2C+Greg&rft.aulast=Bushel&rft.aufirst=Pierre&rft.date=2007-02-23&rft.volume=1&rft.issue=&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=BMC+systems+biology&rft.issn=1752-0509&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-26 N1 - Date created - 2007-04-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Health Perspect. 2003 May;111(6):A338-9 [12760838] BMC Bioinformatics. 2007;8:38 [17270052] Mutat Res. 2003 Nov;544(2-3):349-60 [14644337] Cancer Res. 2004 Mar 1;64(5):1584-8 [14996713] Toxicol Sci. 2004 Jun;79(2):411-22 [15056800] Toxicol Sci. 2004 Jul;80(1):193-202 [15084756] J Virol. 2004 Oct;78(19):10420-32 [15367608] J Pharmacol Exp Ther. 1973 Oct;187(1):195-202 [4746327] Toxicology. 1988 Dec 30;53(2-3):323-9 [3212790] Mol Carcinog. 1999 Mar;24(3):153-9 [10204799] Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6745-50 [10359783] Science. 1999 Oct 15;286(5439):531-7 [10521349] Bioinformatics. 2004 Nov 22;20(17):3137-45 [15217814] Nat Rev Genet. 2004 Dec;5(12):936-48 [15573125] Environ Health Perspect. 2004 Nov;112(16):1589-606 [15598610] Bioinformatics. 2005 Feb 15;21(4):423-9 [15608052] Toxicol Pathol. 2005;33(1):111-7 [15805062] Bioinformatics. 2006 Jan 1;22(1):77-87 [16249259] Bioinformatics. 2006 Jul 15;22(14):e184-90 [16873470] Nat Genet. 2000 May;25(1):25-9 [10802651] Cell. 2000 Jul 7;102(1):109-26 [10929718] J Hepatol. 2000 Sep;33(3):395-406 [11019995] N Engl J Med. 2001 Feb 22;344(8):539-48 [11207349] Bioinformatics. 2001 Apr;17(4):309-18 [11301299] Genome Res. 2001 Aug;11(8):1425-33 [11483584] Toxicol Pathol. 2002 Jan-Feb;30(1):88-92 [11890481] Toxicol Sci. 2002 Jun;67(2):219-31 [12011481] Toxicol Sci. 2002 Jun;67(2):232-40 [12011482] Genet Epidemiol. 2002 Jun;23(1):87-96 [12112250] Curr Opin Mol Ther. 2002 Jun;4(3):229-35 [12139308] Toxicol Pathol. 2002 Jul-Aug;30(4):470-82 [12187938] EHP Toxicogenomics. 2003 Jan;111(1T):53-60 [12735110] Environ Health Perspect. 2003 Aug;111(11):A581-9 [12928155] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Elucidation of the role of peptide linker in calcium-sensing receptor activation process. AN - 69024910; 17189274 AB - Family 3 G-protein-coupled receptors (GPCRs), which includes metabotropic glutamate receptors (mGluRs), sweet and "umami" taste receptors (T1Rs), and the extracellular calcium-sensing receptor (CaR), represent a distinct group among the superfamily of GPCRs characterized by large amino-terminal extracellular ligand-binding domains (ECD) with homology to bacterial periplasmic amino acid-binding proteins that are responsible for signal detection and receptor activation through as yet unresolved mechanism(s) via the seven-transmembrane helical domain (7TMD) common to all GPCRs. To address the mechanism(s) by which ligand-induced conformational changes are conveyed from the ECD to the 7TMD for G-protein activation, we altered the length and composition of a 14-amino acid linker segment common to all family 3 GPCRs except GABA(B) receptor, in the CaR by insertion, deletion, and site-directed mutagenesis of specific highly conserved residues. Small alterations in the length and composition of the linker impaired cell surface expression and abrogated signaling of the chimeric receptors. The exchange of nine amino acids within the linker of CaR with the homologous sequence of mGluR1, however, preserved receptor function. Ala substitution for the four highly conserved residues within this amino acid sequence identified a Leu at position 606 of the CaR critical for cell surface expression and signaling. Substitution of Leu(606) for Ala resulted in impaired cell surface expression. However, Ile and Val substitutions displayed strong activating phenotypes. Disruption of the linker by insertion of nine amino acids of a random-coiled structure uncoupled the ECD from regulating the 7TMD. These data are consistent with a model of receptor activation in which the peptide linker, and particularly Leu(606), provides a critical interaction for the CaR signal transmission, a finding likely to be relevant for all family 3 GPCRs containing this conserved motif. JF - The Journal of biological chemistry AU - Ray, Kausik AU - Adipietro, Kaylin A AU - Chen, Claudia AU - Northup, John K AD - Laboratory of Cellular Biology, NIDCD, National Institutes of Health, Bethesda, Maryland 20892,USA. rayk@nidcd.nih.gov Y1 - 2007/02/23/ PY - 2007 DA - 2007 Feb 23 SP - 5310 EP - 5317 VL - 282 IS - 8 SN - 0021-9258, 0021-9258 KW - Receptors, Calcium-Sensing KW - 0 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Protein Structure, Tertiary -- genetics KW - Amino Acid Motifs -- genetics KW - HeLa Cells KW - Humans KW - Mutation KW - Amino Acid Substitution KW - Calcium Signaling -- physiology KW - Receptors, Calcium-Sensing -- genetics KW - Receptors, Calcium-Sensing -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69024910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Elucidation+of+the+role+of+peptide+linker+in+calcium-sensing+receptor+activation+process.&rft.au=Ray%2C+Kausik%3BAdipietro%2C+Kaylin+A%3BChen%2C+Claudia%3BNorthup%2C+John+K&rft.aulast=Ray&rft.aufirst=Kausik&rft.date=2007-02-23&rft.volume=282&rft.issue=8&rft.spage=5310&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-17 N1 - Date created - 2007-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - EWORS Utilization as a Complementary Surveillance Tool for Detecting Dengue Outbreaks T2 - 2007 International Meeting on Emerging Diseases and Surveillance (IMED 2007) AN - 40627564; 4567579 JF - 2007 International Meeting on Emerging Diseases and Surveillance (IMED 2007) AU - Siswoyo, H AU - Laras, K AU - Suwandono, A AU - Tresnaningsih, E AU - Adimidjaja, T AU - Simanjuntak, C AU - Larasati, R AU - Glass, J Y1 - 2007/02/23/ PY - 2007 DA - 2007 Feb 23 KW - Outbreaks KW - Dengue KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40627564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Meeting+on+Emerging+Diseases+and+Surveillance+%28IMED+2007%29&rft.atitle=EWORS+Utilization+as+a+Complementary+Surveillance+Tool+for+Detecting+Dengue+Outbreaks&rft.au=Siswoyo%2C+H%3BLaras%2C+K%3BSuwandono%2C+A%3BTresnaningsih%2C+E%3BAdimidjaja%2C+T%3BSimanjuntak%2C+C%3BLarasati%2C+R%3BGlass%2C+J&rft.aulast=Siswoyo&rft.aufirst=H&rft.date=2007-02-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Meeting+on+Emerging+Diseases+and+Surveillance+%28IMED+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://imed.isid.org/Downloads/IMED2007_AbstrAuth.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Cytokine Heterogeneity within the Th2 Subset T2 - 2007 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2007) AN - 40535430; 4521337 JF - 2007 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2007) AU - Kim, N AU - Foster, B A AU - Prussin, C Y1 - 2007/02/23/ PY - 2007 DA - 2007 Feb 23 KW - Cytokines KW - Lymphocytes T KW - Helper cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40535430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2007%29&rft.atitle=Identification+of+Cytokine+Heterogeneity+within+the+Th2+Subset&rft.au=Kim%2C+N%3BFoster%2C+B+A%3BPrussin%2C+C&rft.aulast=Kim&rft.aufirst=N&rft.date=2007-02-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BADB9F23F%2D599E%2D4E3C% 2D8BFE%2D532DF96F148F%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cockroach Allergen Reduction by Extermination Alone in Low-Income, Urban Homes-A Randomized Control Trial T2 - 2007 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2007) AN - 40529268; 4522062 JF - 2007 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2007) AU - Sever, M L AU - Arbes Jr., S.J. AU - Zeldin, D C AU - Schal, C AU - Santangelo, R G AU - Gore, J C AU - Vaughn, B AU - Mitchell, H Y1 - 2007/02/23/ PY - 2007 DA - 2007 Feb 23 KW - Socio-economic aspects KW - Allergens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40529268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reading+%26+Writing+Quarterly&rft.atitle=Teaching+Reading+Fluency+to+Struggling+Readers%3A+Method%2C+Materials%2C+and+Evidence&rft.au=Rasinski%2C+Timothy%3BHoman%2C+Susan%3BBiggs%2C+Marie&rft.aulast=Rasinski&rft.aufirst=Timothy&rft.date=2009-04-01&rft.volume=25&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Reading+%26+Writing+Quarterly&rft.issn=10573569&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BADB9F23F%2D599E%2D4E3C% 2D8BFE%2D532DF96F148F%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TGF-beta Stimulated Human CD4+CD25-FOXP3- Cells Express FOXP3, but Lack Regulatory Function T2 - 2007 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2007) AN - 40527830; 4522218 JF - 2007 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2007) AU - Tran, D AU - Shevach, E M Y1 - 2007/02/23/ PY - 2007 DA - 2007 Feb 23 KW - Foxp3 protein KW - Transforming growth factor-b KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40527830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2007%29&rft.atitle=TGF-beta+Stimulated+Human+CD4%2BCD25-FOXP3-+Cells+Express+FOXP3%2C+but+Lack+Regulatory+Function&rft.au=Tran%2C+D%3BShevach%2C+E+M&rft.aulast=Tran&rft.aufirst=D&rft.date=2007-02-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BADB9F23F%2D599E%2D4E3C% 2D8BFE%2D532DF96F148F%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ascaris Antigens Suppress Experimental Allergic Inflammation T2 - 2007 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2007) AN - 40526359; 4521490 JF - 2007 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2007) AU - Trivedi, S AU - Hodges, M G AU - Bundoc, V AU - Norris, H H AU - Boesen, A AU - Madala, S AU - Urban, J F AU - Keane-Myers, A Y1 - 2007/02/23/ PY - 2007 DA - 2007 Feb 23 KW - Hypersensitivity KW - Inflammation KW - Antigens KW - Ascaris KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40526359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2007%29&rft.atitle=Ascaris+Antigens+Suppress+Experimental+Allergic+Inflammation&rft.au=Trivedi%2C+S%3BHodges%2C+M+G%3BBundoc%2C+V%3BNorris%2C+H+H%3BBoesen%2C+A%3BMadala%2C+S%3BUrban%2C+J+F%3BKeane-Myers%2C+A&rft.aulast=Trivedi&rft.aufirst=S&rft.date=2007-02-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BADB9F23F%2D599E%2D4E3C% 2D8BFE%2D532DF96F148F%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Parental Smoking Modifies Effects of Genetic Variation in Tumor Necrosis Factor-a on Childhood Asthma T2 - 2007 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2007) AN - 40521860; 4521557 JF - 2007 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2007) AU - Wu, H. AU - Romieu, I AU - Sienra-Monge, J AU - Rio-Navarro, B AU - Anderson, D M AU - Dunn, E W AU - Steiner, L L AU - Lara-Sanchez, I AU - London, S Y1 - 2007/02/23/ PY - 2007 DA - 2007 Feb 23 KW - Respiratory diseases KW - Asthma KW - Smoking KW - Genetic diversity KW - Tumor necrosis factor-a KW - Children KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40521860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2007%29&rft.atitle=Parental+Smoking+Modifies+Effects+of+Genetic+Variation+in+Tumor+Necrosis+Factor-a+on+Childhood+Asthma&rft.au=Wu%2C+H.%3BRomieu%2C+I%3BSienra-Monge%2C+J%3BRio-Navarro%2C+B%3BAnderson%2C+D+M%3BDunn%2C+E+W%3BSteiner%2C+L+L%3BLara-Sanchez%2C+I%3BLondon%2C+S&rft.aulast=Wu&rft.aufirst=H.&rft.date=2007-02-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BADB9F23F%2D599E%2D4E3C% 2D8BFE%2D532DF96F148F%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study AN - 20745439; 7436524 AB - Background Seafood is the predominant source of omega-3 fatty adds, which are essential for optimum neural development However, in the USA, women are advised to limit their seafood intake during pregnancy to 340 g per week. We used the Avon Longitudinal Study of Parents and Children (ALSPAC) to assess the possible benefits and hazards to a child's development of different levels of maternal seafood intake during pregnancy. Methods 11875 pregnant women completed a food frequency questionnaire assessing seafood consumption at 32 weeks' gestation. Multivariable logistic regression models including 28 potential confounders assessing social disadvantage, perinatal, and dietary items were used to compare developmental, behavioural, and cognitive outcomes of the children from age 6 months to 8 years in women consuming none, some (1-340 g per week), and >340 g per week. Findings After adjustment, maternal seafood intake during pregnancy of less than 340 g per week was associated with increased risk of their children being in the lowest quartile for verbal intelligence quotient (IQ) (no seafood consumption, odds ratio [OR] 1.48, 95% CI 1.16-1.90; some, 1.09, 0.92-1.29; overall trend, p=0.004), compared with mothers who consumed more than 340 g per week. Low maternal seafood intake was also associated with increased risk of suboptimum outcomes for prosocial behaviour, fine motor, communication, and social development scores. For each outcome measure, the lower the intake of seafood during pregnancy, the higher the risk of suboptimum developmental outcome. Interpretation Maternalseafood consumption of less than 340 g per week in pregnancy did not protect children from adverse outcomes; rather, we recorded beneficial effects on child development with maternal seafood intakes of more than 340 g per week, suggesting that advice to limit seafood consumption could actually be detrimental. These results show that risks from the loss of nutrients were greater than the risks of harm from exposure to trace contaminants in 340 g seafood eaten weekly. JF - Lancet AU - Hibbeln, J R AU - Davis, J M AU - Steer, C AU - Emmett, P AU - Rogers, I AU - Williams, C AU - Golding, J AD - Laboratory of Membrane Biophysics and Biochemistry, US National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, MD 20952, USA, jhibbeln@mail.nih.gov Y1 - 2007/02/23/ PY - 2007 DA - 2007 Feb 23 SP - 578 EP - 585 VL - 369 IS - 9561 SN - 0099-5355, 0099-5355 KW - CSA Neurosciences Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - Longitudinal studies KW - Food KW - Communication KW - Nutrients KW - Risk factors KW - Gestation KW - Regression analysis KW - Seafood KW - intelligence KW - Diets KW - Inventories KW - Children KW - Pregnancy KW - nutrients KW - Intelligence KW - USA KW - Cognitive ability KW - Neurotoxicity KW - Contaminants KW - longitudinal studies KW - N3 11028:Neuropharmacology & toxicology KW - X 24320:Food Additives & Contaminants KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20745439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=The+effect+of+haem+in+red+and+processed+meat+on+the+endogenous+formation+of+N-nitroso+compounds+in+the+upper+gastrointestinal+tract&rft.au=Lunn%2C+J+C%3BKuhnle%2C+G%3BMai%2C+V%3BFrankenfeld%2C+C%3BShuker%2C+DEG%3BGlen%2C+R+C%3BGoodman%2C+J+M%3BPollock%2C+JRA%3BBingham%2C+SA&rft.aulast=Lunn&rft.aufirst=J&rft.date=2007-03-01&rft.volume=28&rft.issue=3&rft.spage=685&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Inventories; Food; Communication; Nutrients; Children; Pregnancy; Intelligence; Cognitive ability; Risk factors; Gestation; Regression analysis; Seafood; Contaminants; Longitudinal studies; Diets; nutrients; Neurotoxicity; longitudinal studies; intelligence; USA ER - TY - CPAPER T1 - Consistency and Reliability of Responses to Imagery-Induced Tobacco Craving over Multiple Sessions T2 - 13th Annual Meeting of the Society for Research on Nicotine and Tobacco AN - 40658152; 4579031 JF - 13th Annual Meeting of the Society for Research on Nicotine and Tobacco AU - Lee, Dustin C AU - Myers, Carol S AU - Taylor, Richard C AU - Moolchan, Eric T AU - Heishman, Stephen J Y1 - 2007/02/21/ PY - 2007 DA - 2007 Feb 21 KW - Tobacco KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40658152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=Consistency+and+Reliability+of+Responses+to+Imagery-Induced+Tobacco+Craving+over+Multiple+Sessions&rft.au=Lee%2C+Dustin+C%3BMyers%2C+Carol+S%3BTaylor%2C+Richard+C%3BMoolchan%2C+Eric+T%3BHeishman%2C+Stephen+J&rft.aulast=Lee&rft.aufirst=Dustin&rft.date=2007-02-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=&rft_id=info:doi/ L2 - http://www.srnt.org/meeting/2007/pdf/onsite/2007SRNTAbstracts-FINAL.pd f LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - State-Level Youth Access Legislation and Indoor Smoking Restrictions Among School-Aged Children T2 - 13th Annual Meeting of the Society for Research on Nicotine and Tobacco AN - 40656743; 4579286 JF - 13th Annual Meeting of the Society for Research on Nicotine and Tobacco AU - Botello-Harbaum, Maria T AU - Iannotti, Ronald J AU - Haynie, Denise AU - Gase, Lauren AU - Simons-Morton, Bruce Y1 - 2007/02/21/ PY - 2007 DA - 2007 Feb 21 KW - Smoking KW - Children KW - Legislation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40656743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=State-Level+Youth+Access+Legislation+and+Indoor+Smoking+Restrictions+Among+School-Aged+Children&rft.au=Botello-Harbaum%2C+Maria+T%3BIannotti%2C+Ronald+J%3BHaynie%2C+Denise%3BGase%2C+Lauren%3BSimons-Morton%2C+Bruce&rft.aulast=Botello-Harbaum&rft.aufirst=Maria&rft.date=2007-02-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=&rft_id=info:doi/ L2 - http://www.srnt.org/meeting/2007/pdf/onsite/2007SRNTAbstracts-FINAL.pd f LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Consumer Awareness and Attitudes Related to New Potential Reduce-Exposure Tobacco Product Brands T2 - 13th Annual Meeting of the Society for Research on Nicotine and Tobacco AN - 40655419; 4578961 JF - 13th Annual Meeting of the Society for Research on Nicotine and Tobacco AU - Parascandola, Mark AU - Augustson, Erik AU - Hurd, Ami AU - Marcus, Stephen Y1 - 2007/02/21/ PY - 2007 DA - 2007 Feb 21 KW - Attitudes KW - Tobacco KW - Consumers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40655419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=Consumer+Awareness+and+Attitudes+Related+to+New+Potential+Reduce-Exposure+Tobacco+Product+Brands&rft.au=Parascandola%2C+Mark%3BAugustson%2C+Erik%3BHurd%2C+Ami%3BMarcus%2C+Stephen&rft.aulast=Parascandola&rft.aufirst=Mark&rft.date=2007-02-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=&rft_id=info:doi/ L2 - http://www.srnt.org/meeting/2007/pdf/onsite/2007SRNTAbstracts-FINAL.pd f LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Pilot Study Testing Feasibility and Efficacy of Nicotine Replacement Therapy in Pregnant African American Smokers T2 - 13th Annual Meeting of the Society for Research on Nicotine and Tobacco AN - 40654120; 4579222 JF - 13th Annual Meeting of the Society for Research on Nicotine and Tobacco AU - El-Mohandes, Ayman Y1 - 2007/02/21/ PY - 2007 DA - 2007 Feb 21 KW - Africa KW - Nicotine KW - Ethnic groups KW - Feasibility studies KW - Pregnancy KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40654120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=A+Pilot+Study+Testing+Feasibility+and+Efficacy+of+Nicotine+Replacement+Therapy+in+Pregnant+African+American+Smokers&rft.au=El-Mohandes%2C+Ayman&rft.aulast=El-Mohandes&rft.aufirst=Ayman&rft.date=2007-02-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=&rft_id=info:doi/ L2 - http://www.srnt.org/meeting/2007/pdf/onsite/2007SRNTAbstracts-FINAL.pd f LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of Other Tobacco Products Among U.S. Adult Cigarette Smokers T2 - 13th Annual Meeting of the Society for Research on Nicotine and Tobacco AN - 40652973; 4579175 JF - 13th Annual Meeting of the Society for Research on Nicotine and Tobacco AU - Backinger, Cathy L AU - Fagan, Pebbles AU - OConnell, Mary E AU - Grana, Rachel Y1 - 2007/02/21/ PY - 2007 DA - 2007 Feb 21 KW - USA KW - Tobacco KW - Cigarettes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40652973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=US-China+Education+Review&rft.atitle=Special+Needs+Students+in+Higher+Education&rft.au=Jones%2C+Lise+Oen%3BKrumsvik%2C+Rune&rft.aulast=Jones&rft.aufirst=Lise&rft.date=2008-03-01&rft.volume=5&rft.issue=3&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=US-China+Education+Review&rft.issn=15486613&rft_id=info:doi/ L2 - http://www.srnt.org/meeting/2007/pdf/onsite/2007SRNTAbstracts-FINAL.pd f LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Tissue-specific activity of the blind mole rat and the two nucleotide-mutated mouse alphaB-crystallin promoter in transgenic mice. AN - 70279991; 17293452 AB - The alphaB-crystallin and HspB2 genes are located approximately 0.9 kb apart in a head-to-head arrangement in mammals. Previous experiments have shown that a truncated -668/+45 alphaB-crystallin enhancer/promoter fragment from blind mole rats (Spalax ehrenbergi), which have nonfunctional lenses, lacks lens activity and has enhanced muscle activity in transgenic mice. Here we show that the full-length mole rat alphaB-crystallin intergenic region behaves similarly in transgenic mice. A two-nucleotide mutation ((-273)CA-->G) in the mouse alphaB-crystallin enhancer/promoter fragment mimicking the wild-type mole rat sequence functionally converted the mouse promoter fragment to that of the wild-type mole rat promoter when tested in transgenic mice. The reciprocal mutation in the mole rat promoter fragment ((-272)G-->CA) did not affect its activity. Oligonucleotides from the wild-type mouse and mole rat alphaB-crystallin promoter region under study formed distinct complexes with nuclear proteins from cultured cells. The mouse mutant sequence lost binding ability, whereas the mutated mole rat sequence gained the ability to form a complex similar in size to that of the wild-type mouse oligonucleotide. Our data support the idea that blind mole rats' alphaB-crystallin promoter activity was modified during the evolution of subterranean life and shows that tissue-specific promoter activity can be modulated by changing as few as two apparently neutral nucleotides in the mouse alphaB-crystallin enhancer region, implying the importance of the context of regulatory sequences for promoter activity. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Li, Yan AU - Hough, R Barry AU - Piatigorsky, Joram AD - Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, 7 Memorial Drive, Bethesda, MD 20892-0704, USA. Y1 - 2007/02/20/ PY - 2007 DA - 2007 Feb 20 SP - 2608 EP - 2613 VL - 104 IS - 8 SN - 0027-8424, 0027-8424 KW - Nucleotides KW - 0 KW - alpha-Crystallin B Chain KW - Index Medicus KW - Animals KW - Base Sequence KW - Electrophoretic Mobility Shift Assay KW - Molecular Sequence Data KW - Mice KW - Amino Acid Sequence KW - Mice, Transgenic KW - Mutagenesis KW - Nucleotides -- genetics KW - Spalax -- metabolism KW - alpha-Crystallin B Chain -- chemistry KW - Mutation -- genetics KW - Promoter Regions, Genetic -- genetics KW - Organ Specificity KW - alpha-Crystallin B Chain -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70279991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Tissue-specific+activity+of+the+blind+mole+rat+and+the+two+nucleotide-mutated+mouse+alphaB-crystallin+promoter+in+transgenic+mice.&rft.au=Li%2C+Yan%3BHough%2C+R+Barry%3BPiatigorsky%2C+Joram&rft.aulast=Li&rft.aufirst=Yan&rft.date=2007-02-20&rft.volume=104&rft.issue=8&rft.spage=2608&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-12 N1 - Date created - 2007-03-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genomics. 1997 Oct 15;45(2):386-94 [9344664] Nucleic Acids Res. 1994 Apr 11;22(7):1281-6 [8165144] J Biol Chem. 1998 Jul 10;273(28):17954-61 [9651402] Nucleic Acids Res. 1998 Oct 15;26(20):4574-81 [9753723] Nature. 1999 Mar 18;398(6724):236-9 [10094045] J Biol Chem. 1999 Jul 9;274(28):19973-8 [10391946] Mol Vis. 1999 Jul 15;5:12 [10407063] J Mol Biol. 2004 Nov 19;344(2):351-68 [15522290] J Mol Evol. 2004 Nov;59(5):674-86 [15693623] Plant Cell. 2005 Mar;17(3):676-90 [15705952] Cell Mol Life Sci. 2005 Aug;62(16):1779-83 [15968467] EMBO J. 2006 May 17;25(10):2107-18 [16675956] Heredity (Edinb). 2006 Sep;97(3):139-47 [16850038] Proc Natl Acad Sci U S A. 1985 Sep;82(17):5819-23 [3862098] Proc Natl Acad Sci U S A. 1986 May;83(10):3131-5 [3010278] Mol Cell Biol. 1986 Nov;6(11):4130-2 [3025636] Proc Natl Acad Sci U S A. 1987 Aug;84(15):5320-4 [3474658] Genes Dev. 1987 Oct;1(8):818-28 [2828173] Mol Biol Evol. 1985 Jul;2(4):279-88 [3870862] Mech Dev. 2000 Apr;92(2):125-34 [10727852] Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6597-602 [10841559] Gene. 2001 Feb 7;264(1):45-9 [11245977] Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8145-50 [12060761] Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11718-23 [12193657] J Biol Chem. 2002 Dec 20;277(51):49700-6 [12403771] Mol Biol Evol. 2003 Sep;20(9):1377-419 [12777501] Curr Biol. 2003 Dec 2;13(23):2118-23 [14654003] J Biol Rhythms. 2004 Feb;19(1):22-34 [14964701] Nature. 2004 Jul 1;430(6995):85-8 [15229602] Adv Enzymol Relat Areas Mol Biol. 1994;69:155-201 [7817868] Development. 1994 Apr;120(4):957-71 [7600971] Gene. 1995 Sep 11;162(2):267-70 [7557441] Mol Cell Biol. 1995 Dec;15(12):7081-90 [8524275] Eur J Biochem. 1996 Feb 1;235(3):449-65 [8654388] Bioessays. 1996 Aug;18(8):621-30 [8760335] J Biol Chem. 1996 Sep 20;271(38):23029-36 [8798491] Annu Rev Biochem. 1988;57:479-504 [3052280] Science. 1988 Dec 16;242(4885):1566-70 [3059495] Biochem Biophys Res Commun. 1989 Jan 16;158(1):319-25 [2912453] Mol Cell Biol. 1989 Mar;9(3):1083-91 [2725488] J Biol Chem. 1989 Nov 25;264(33):19837-44 [2584197] Trends Biochem Sci. 1989 Sep;14(9):365-8 [2688200] Prog Clin Biol Res. 1990;335:383-95 [2408079] Invest Ophthalmol Vis Sci. 1990 Jul;31(7):1398-404 [2142147] Mol Cell Biol. 1991 Sep;11(9):4340-9 [1875925] J Biol Chem. 1992 Mar 5;267(7):4277-80 [1537817] Mol Biol Evol. 1993 Jan;10(1):103-26 [8450753] Mol Cell Biol. 1993 Nov;13(11):7144-52 [8413303] J Cell Biol. 1998 Mar 9;140(5):1113-24 [9490724] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Physiologic Functions of Lipids as Revealed by Knockout Mice T2 - 2007 Keystone Symposia on Bioactive Lipids in the Lipidomics Era (C2) AN - 40538199; 4516823 JF - 2007 Keystone Symposia on Bioactive Lipids in the Lipidomics Era (C2) AU - Proia, Richard L Y1 - 2007/02/20/ PY - 2007 DA - 2007 Feb 20 KW - Lipids KW - Mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40538199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Bioactive+Lipids+in+the+Lipidomics+Era+%28C2%29&rft.atitle=Physiologic+Functions+of+Lipids+as+Revealed+by+Knockout+Mice&rft.au=Proia%2C+Richard+L&rft.aulast=Proia&rft.aufirst=Richard&rft.date=2007-02-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Bioactive+Lipids+in+the+Lipidomics+Era+%28C2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=86 1&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - 3'-H-Phosphonate Synthesis of Chiral Benzo[a]pyrene Diol Epoxide Adducts at N super(2) of Deoxyguanosine in Oligonucleotides AN - 19611171; 7326438 AB - A synthetic route to oligonucleotides containing N super(2)-deoxyguanosine adducts at C-10 of the enantiomeric 7,8-diol 9,10-epoxides of 7,8,9,10-tetrahydrobenzo[a]pyrene in which the epoxide oxygen and the 7-hydroxyl group are trans is described. The present adducts result from the trans addition of N super(2) of deoxyguanosine to the epoxide at C-10. Our synthesis proceeds via preparation of the 3'-H-phosphonate of a suitably protected deoxyguanosine N super(2)-adduct. The blocking groups consisted of O super(6)-allyl on the deoxyguanosine, acetates on the 7-, 8-, and 9-hydroxyl groups of the hydrocarbon moiety, and dimethoxytrityl on the 5'-hydroxyl group of the sugar. These blocking groups are well suited to oligonucleotide synthesis on solid supports. The free 3'-hydroxyl group of this nucleoside adduct was readily converted to its 3'-H-phosphonate with diphenyl phosphite in pyridine in high yield for both the 10R and 10S isomers. For synthesis of oligonucleotides, the first several nucleotides were incorporated onto the solid support with an automated synthesizer using standard phosphoramidite chemistry. The adducted deoxyguanilic acid residue was introduced as the H-phosphonate in a manual step (80% yield), followed by completion of the sequence on the synthesizer. Although a 10-fold excess of the 3'-H-phosphonate was used in the manual coupling step, as much as 70% of the reactant could be recovered. The 3'-H-phosphonate of the protected 10S nucleoside adduct was converted to the unblocked nucleotide adduct, various salts of which failed to form crystals suitable for X-ray analysis. Although submilligram quantities of this compound have been formed as mixed diastereomers by direct reaction of deoxyguanylic acid with racemic diol epoxide, the present study represents the first actual synthesis of the major DNA adduct formed from benzo[a]pyrene in mammals as its 3'-phosphate. JF - Chemical Research in Toxicology AU - Iyer, P C AU - Yagi, H AU - Sayer, J M AU - Jerina, D M AD - Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, DHHS, Bethesda, Maryland 20892 Y1 - 2007/02/19/ PY - 2007 DA - 2007 Feb 19 SP - 311 EP - 315 VL - 20 IS - 2 SN - 0893-228X, 0893-228X KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - DNA adducts KW - Sugar KW - Epoxides KW - Hydrocarbons KW - Adducts KW - Crystals KW - N2-deoxyguanosine KW - Acetic acid KW - Deoxyguanosine KW - Oligonucleotides KW - Nucleotides KW - Isomers KW - Salts KW - Oxygen KW - pyridines KW - nucleosides KW - Pyridine KW - Benzo(a)pyrene KW - N 14840:Antisense, Nucleotide Analogs KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19611171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Research+in+Toxicology&rft.atitle=3%27-H-Phosphonate+Synthesis+of+Chiral+Benzo%5Ba%5Dpyrene+Diol+Epoxide+Adducts+at+N+super%282%29+of+Deoxyguanosine+in+Oligonucleotides&rft.au=Iyer%2C+P+C%3BYagi%2C+H%3BSayer%2C+J+M%3BJerina%2C+D+M&rft.aulast=Iyer&rft.aufirst=P&rft.date=2007-02-19&rft.volume=20&rft.issue=2&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=Chemical+Research+in+Toxicology&rft.issn=0893228X&rft_id=info:doi/10.1021%2Ftx600282y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Sugar; DNA adducts; Epoxides; Hydrocarbons; Adducts; Crystals; N2-deoxyguanosine; Oligonucleotides; Deoxyguanosine; Acetic acid; Nucleotides; Isomers; pyridines; Oxygen; Salts; nucleosides; Pyridine; Benzo(a)pyrene DO - http://dx.doi.org/10.1021/tx600282y ER - TY - JOUR T1 - Role of IL-6 in an IL-10 and IL-4 Double Knockout Mouse Model Uniquely Susceptible to Acetaminophen-Induced Liver Injury AN - 19610023; 7326428 AB - Drug-induced hepatitis remains a challenging problem for drug development and safety because of the lack of animal models. In the current work, we discovered a unique interaction that makes mice deficient in both IL-10 and IL-4 (IL-10/4 super(-/-)) highly sensitive to the hepatotoxic effects of acetaminophen (APAP). Male C57B1/6 wild type (WT) and mice deficient in one or more cytokines were treated with 120 mg/kg APAP. Within 24 h after WT, IL-10 super(-/-), IL-4 super(-/-), or IL-10/4 super(-/-) mice were administered APAP, 75% of the IL-10/4 super(-/-)mice died of massive hepatic injury while all other genotypes were resistant to liver toxicity at this dose of APAP. The unique susceptibility of IL-10/4 super(-/-) mice was associated with reduced levels of liver glutathione and remarkably high serum levels of IL-6 and several proinflammatory factors including TNF- alpha , IFN- gamma , macrophage inflammatory protein-1 alpha (MIP-1 alpha ), monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-2 (MIP-2), and osteopontin (OPN) as well as nitric oxide (NO). IL-6 appeared to have a causal role in controlling the unique susceptibility of IL-10/4 super(-/-) mice to APAP-induced liver disease (AILD) because IL-6 neutralizing antibody reversed the high sensitivity of these mice to AILD. Moreover, IL-10/4/6 super(-/-) mice were also resistant to the enhanced susceptibility to AILD and expressed relatively low levels of most proinflammatory factor genes that were elevated in the IL-10/4 super(-/-) mice. In conclusion, liver homeostasis following AILD appears to be highly dependent on the activities of both IL-10 and IL-4, which together help prevent overexpression of IL-6 and other potential hepatotoxic factors. JF - Chemical Research in Toxicology AU - Bourdi, M AU - Eiras, D P AU - Holt, M P AU - Webster, M R AU - Reilly, T P AU - Welch, K D AU - Pohl, L R AD - Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland Y1 - 2007/02/19/ PY - 2007 DA - 2007 Feb 19 SP - 208 EP - 216 VL - 20 IS - 2 SN - 0893-228X, 0893-228X KW - Virology & AIDS Abstracts; Genetics Abstracts; Toxicology Abstracts; Immunology Abstracts KW - Macrophages KW - Interleukin 6 KW - gamma -Interferon KW - Interleukin 4 KW - Injuries KW - Glutathione KW - Animal models KW - Homeostasis KW - Genotypes KW - Interleukin 10 KW - Acetaminophen KW - Liver diseases KW - Monocyte chemoattractant protein 1 KW - macrophage inflammatory protein 1 KW - Drug development KW - Toxicity KW - Inflammation KW - Hepatitis KW - Serum levels KW - Antibodies KW - Osteopontin KW - Nitric oxide KW - Tumor necrosis factor- alpha KW - Side effects KW - V 22410:Animal Diseases KW - X 24310:Pharmaceuticals KW - F 06955:Immunomodulation & Immunopharmacology KW - G 07710:Chemical Mutagenesis & Radiation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19610023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Research+in+Toxicology&rft.atitle=Role+of+IL-6+in+an+IL-10+and+IL-4+Double+Knockout+Mouse+Model+Uniquely+Susceptible+to+Acetaminophen-Induced+Liver+Injury&rft.au=Bourdi%2C+M%3BEiras%2C+D+P%3BHolt%2C+M+P%3BWebster%2C+M+R%3BReilly%2C+T+P%3BWelch%2C+K+D%3BPohl%2C+L+R&rft.aulast=Bourdi&rft.aufirst=M&rft.date=2007-02-19&rft.volume=20&rft.issue=2&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=Chemical+Research+in+Toxicology&rft.issn=0893228X&rft_id=info:doi/10.1021%2Ftx0602281 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Macrophages; gamma -Interferon; Interleukin 4; Monocyte chemoattractant protein 1; Liver diseases; Injuries; macrophage inflammatory protein 1; Glutathione; Animal models; Drug development; Genotypes; Homeostasis; Toxicity; Interleukin 10; Inflammation; Serum levels; Hepatitis; Antibodies; Osteopontin; Nitric oxide; Tumor necrosis factor- alpha; Side effects; Acetaminophen DO - http://dx.doi.org/10.1021/tx0602281 ER - TY - CPAPER T1 - Level Sets on Non-Planar Manifolds for Ridge Detection on Isosurfaces T2 - 2007 SPIE Conference on Medical Imaging AN - 40538607; 4523505 JF - 2007 SPIE Conference on Medical Imaging AU - Tan, S AU - Yao, J AU - Ward, M M AU - Yao, L AU - Summers, R M Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Ridges KW - Manifolds KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40538607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+SPIE+Conference+on+Medical+Imaging&rft.atitle=Level+Sets+on+Non-Planar+Manifolds+for+Ridge+Detection+on+Isosurfaces&rft.au=Tan%2C+S%3BYao%2C+J%3BWard%2C+M+M%3BYao%2C+L%3BSummers%2C+R+M&rft.aulast=Tan&rft.aufirst=S&rft.date=2007-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+SPIE+Conference+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Parsimonious Model Selection for Tissue Classification: A DTI Study of Zebrafish T2 - 2007 SPIE Conference on Medical Imaging AN - 40537656; 4523498 JF - 2007 SPIE Conference on Medical Imaging AU - Freidlin, R Z AU - Loew, M H AU - Basser, P J Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Classification KW - Models KW - Freshwater fish KW - Danio rerio KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40537656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+SPIE+Conference+on+Medical+Imaging&rft.atitle=Parsimonious+Model+Selection+for+Tissue+Classification%3A+A+DTI+Study+of+Zebrafish&rft.au=Freidlin%2C+R+Z%3BLoew%2C+M+H%3BBasser%2C+P+J&rft.aulast=Freidlin&rft.aufirst=R&rft.date=2007-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+SPIE+Conference+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Two CAD Systems for Breast Cancer using Dynamic Contrast Enhanced MRI T2 - 2007 SPIE Conference on Medical Imaging AN - 40537176; 4523730 JF - 2007 SPIE Conference on Medical Imaging AU - Chattrabhuti, K AU - Yao, J AU - Hill, S AU - Chow, C Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Breast cancer KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40537176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Music+Educators+Journal&rft.atitle=Children+with+Disabilities+Playing+Musical+Instruments%3A+With+the+Right+Adaptations+and+Help+from+Their+Teachers+and+Parents%2C+Students+with+Disabilities+Can+Play+Musical+Instruments&rft.au=McCord%2C+Kimberly%3BFitzgerald%2C+Margaret&rft.aulast=McCord&rft.aufirst=Kimberly&rft.date=2006-03-01&rft.volume=92&rft.issue=4&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Music+Educators+Journal&rft.issn=00274321&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Improved Livewire Method for Segmentation on Low-Contrast and Noisy Images T2 - 2007 SPIE Conference on Medical Imaging AN - 40535867; 4523504 JF - 2007 SPIE Conference on Medical Imaging AU - Chen, D AU - Yao, J Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Segmentation KW - Image processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40535867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+SPIE+Conference+on+Medical+Imaging&rft.atitle=Improved+Livewire+Method+for+Segmentation+on+Low-Contrast+and+Noisy+Images&rft.au=Chen%2C+D%3BYao%2C+J&rft.aulast=Chen&rft.aufirst=D&rft.date=2007-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+SPIE+Conference+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Collaborative Classifiers in CT Colonography CAD T2 - 2007 SPIE Conference on Medical Imaging AN - 40535848; 4523751 DE: JF - 2007 SPIE Conference on Medical Imaging AU - Yao, J AU - Li, J. AU - Summers, R M Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40535848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+SPIE+Conference+on+Medical+Imaging&rft.atitle=Collaborative+Classifiers+in+CT+Colonography+CAD&rft.au=Yao%2C+J%3BLi%2C+J.%3BSummers%2C+R+M&rft.aulast=Yao&rft.aufirst=J&rft.date=2007-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+SPIE+Conference+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Performance Analysis of Cervix Roi Extraction and Specular Reflection Removal Algorithms for Uterine Cervix Image Indexing T2 - 2007 SPIE Conference on Medical Imaging AN - 40534449; 4523561 JF - 2007 SPIE Conference on Medical Imaging AU - Xue, Z AU - Antani, S K AU - Long, L R AU - Jeronimo, J AU - Thoma, G R Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Indexing KW - Cervix KW - Algorithms KW - Uterus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40534449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+SPIE+Conference+on+Medical+Imaging&rft.atitle=Comparative+Performance+Analysis+of+Cervix+Roi+Extraction+and+Specular+Reflection+Removal+Algorithms+for+Uterine+Cervix+Image+Indexing&rft.au=Xue%2C+Z%3BAntani%2C+S+K%3BLong%2C+L+R%3BJeronimo%2C+J%3BThoma%2C+G+R&rft.aulast=Xue&rft.aufirst=Z&rft.date=2007-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+SPIE+Conference+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Semi-Automatic Tissue Classification of Magnetic Resonance Images of the Thigh for Application to Large-Scale Datasets T2 - 2007 SPIE Conference on Medical Imaging AN - 40533748; 4523528 JF - 2007 SPIE Conference on Medical Imaging AU - Monzon, A AU - Hemler, P F AU - Nalls, M A AU - Manini, T M AU - Clark, B C AU - Harris, T AU - McAuliffe, M J Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Magnetic resonance imaging KW - Classification KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40533748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+SPIE+Conference+on+Medical+Imaging&rft.atitle=Semi-Automatic+Tissue+Classification+of+Magnetic+Resonance+Images+of+the+Thigh+for+Application+to+Large-Scale+Datasets&rft.au=Monzon%2C+A%3BHemler%2C+P+F%3BNalls%2C+M+A%3BManini%2C+T+M%3BClark%2C+B+C%3BHarris%2C+T%3BMcAuliffe%2C+M+J&rft.aulast=Monzon&rft.aufirst=A&rft.date=2007-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+SPIE+Conference+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Validating Pareto Optimal Operation Parameters of Polyp Detection Algorithms for CT Colonography T2 - 2007 SPIE Conference on Medical Imaging AN - 40531228; 4523750 JF - 2007 SPIE Conference on Medical Imaging AU - Li, J. AU - Huang, A AU - Petrick, N A AU - Yao, J AU - Summers, R M Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Polyps KW - Algorithms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40531228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=A+comprehensive+investigation+of+2-amino-1-methyl-6-phenylimidazo%5B4%2C5-b%5Dpyridine+%28PhIP%29+metabolism+in+the+mouse+using+a+multivariate+data+analysis+approach.&rft.au=Chen%2C+Chi%3BMa%2C+Xiaochao%3BMalfatti%2C+Michael+A%3BKrausz%2C+Kristopher+W%3BKimura%2C+Shioko%3BFelton%2C+James+S%3BIdle%2C+Jeffrey+R%3BGonzalez%2C+Frank+J&rft.aulast=Chen&rft.aufirst=Chi&rft.date=2007-03-01&rft.volume=20&rft.issue=3&rft.spage=531&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gaps in Content-Based Image Retrieval T2 - 2007 SPIE Conference on Medical Imaging AN - 40529721; 4523346 JF - 2007 SPIE Conference on Medical Imaging AU - Lehmann, T M AU - Antani, S K AU - Long, L R Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Data processing KW - Databases KW - Mining KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40529721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemistry+%26+biology&rft.atitle=Chemical+genetic+screening+identifies+critical+pathways+in+anthrax+lethal+toxin-induced+pathogenesis.&rft.au=Panchal%2C+Rekha+G%3BRuthel%2C+Gordon%3BBrittingham%2C+Katherine+C%3BLane%2C+Douglas%3BKenny%2C+Tara+A%3BGussio%2C+Rick%3BLazo%2C+John+S%3BBavari%2C+Sina&rft.aulast=Panchal&rft.aufirst=Rekha&rft.date=2007-03-01&rft.volume=14&rft.issue=3&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Chemistry+%26+biology&rft.issn=10745521&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - (ST) Intra-Patient Colon Surface Registration Based on Taeniae coli T2 - 2007 SPIE Conference on Medical Imaging AN - 40529577; 4523246 JF - 2007 SPIE Conference on Medical Imaging AU - Lamy, J AU - Summers, R M Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Colon KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40529577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+SPIE+Conference+on+Medical+Imaging&rft.atitle=%28ST%29+Intra-Patient+Colon+Surface+Registration+Based+on+Taeniae+coli&rft.au=Lamy%2C+J%3BSummers%2C+R+M&rft.aulast=Lamy&rft.aufirst=J&rft.date=2007-02-17&rft.volume=42&rft.issue=3&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=Reading+Improvement&rft.issn=00340510&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Colonic Wall Thickness using Level Sets for CT Virtual Colonoscopy Visual Assessment and Polyp Detection T2 - 2007 SPIE Conference on Medical Imaging AN - 40529569; 4523101 JF - 2007 SPIE Conference on Medical Imaging AU - Van Uitert, R. AU - Summers, R M Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Polyps KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40529569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+SPIE+Conference+on+Medical+Imaging&rft.atitle=Colonic+Wall+Thickness+using+Level+Sets+for+CT+Virtual+Colonoscopy+Visual+Assessment+and+Polyp+Detection&rft.au=Van+Uitert%2C+R.%3BSummers%2C+R+M&rft.aulast=Van+Uitert&rft.aufirst=R.&rft.date=2007-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+SPIE+Conference+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Optimal Parameters and Pitfalls for Kernel Method of Surface Curvature Estimation for CT Colonography Computer-Aided Polyp Detection T2 - 2007 SPIE Conference on Medical Imaging AN - 40527353; 4523455 JF - 2007 SPIE Conference on Medical Imaging AU - Campbell, S AU - Summers, R M Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Polyps KW - Kernels KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40527353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+SPIE+Conference+on+Medical+Imaging&rft.atitle=Optimal+Parameters+and+Pitfalls+for+Kernel+Method+of+Surface+Curvature+Estimation+for+CT+Colonography+Computer-Aided+Polyp+Detection&rft.au=Campbell%2C+S%3BSummers%2C+R+M&rft.aulast=Campbell&rft.aufirst=S&rft.date=2007-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+SPIE+Conference+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using Pareto Fronts to Evaluate Polyp Detection Algorithms for CT Colonography T2 - 2007 SPIE Conference on Medical Imaging AN - 40527188; 4523241 JF - 2007 SPIE Conference on Medical Imaging AU - Huang, A AU - Li, J. AU - Summers, R M AU - Petrick, N A AU - Hara, A K Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Polyps KW - Algorithms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40527188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+SPIE+Conference+on+Medical+Imaging&rft.atitle=Using+Pareto+Fronts+to+Evaluate+Polyp+Detection+Algorithms+for+CT+Colonography&rft.au=Huang%2C+A%3BLi%2C+J.%3BSummers%2C+R+M%3BPetrick%2C+N+A%3BHara%2C+A+K&rft.aulast=Huang&rft.aufirst=A&rft.date=2007-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+SPIE+Conference+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using the Teniae Coli as a Registration Tool in CT Colonography T2 - 2007 SPIE Conference on Medical Imaging AN - 40525950; 4523103 JF - 2007 SPIE Conference on Medical Imaging AU - Jabour, P A AU - Huang, A AU - Summers, R M Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Endoscopy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40525950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+SPIE+Conference+on+Medical+Imaging&rft.atitle=Using+the+Teniae+Coli+as+a+Registration+Tool+in+CT+Colonography&rft.au=Jabour%2C+P+A%3BHuang%2C+A%3BSummers%2C+R+M&rft.aulast=Jabour&rft.aufirst=P&rft.date=2007-02-17&rft.volume=1&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Politics+%26+Gender&rft.issn=1743923X&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exploring Access to Scientific Literature using Content-Based Image Retrieval T2 - 2007 SPIE Conference on Medical Imaging AN - 40525549; 4523348 JF - 2007 SPIE Conference on Medical Imaging AU - Lehmann, T M AU - Antani, S K AU - Long, L R Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Data processing KW - Databases KW - Mining KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40525549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+SPIE+Conference+on+Medical+Imaging&rft.atitle=Exploring+Access+to+Scientific+Literature+using+Content-Based+Image+Retrieval&rft.au=Lehmann%2C+T+M%3BAntani%2C+S+K%3BLong%2C+L+R&rft.aulast=Lehmann&rft.aufirst=T&rft.date=2007-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+SPIE+Conference+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Ca2+/calmodulin kinase II-dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes. AN - 69018890; 17234969 AB - The multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta(C) (CaMKIIdelta(C)) is found in the macromolecular complex of type 2 ryanodine receptor (RyR2) Ca(2+) release channels in the heart. However, the functional role of CaMKII-dependent phosphorylation of RyR2 is highly controversial. To address this issue, we expressed wild-type, constitutively active, or dominant-negative CaMKIIdelta(C) via adenoviral gene transfer in cultured adult rat ventricular myocytes. CaMKII-mediated phosphorylation of RyR2 was reduced, enhanced, or unaltered by dominant-negative, constitutively active, or wild-type CaMKIIdelta(C) expression, whereas phosphorylation of phospholamban at Thr17, an endogenous indicator of CaMKII activity, was at 73%, 161%, or 115% of the control group expressing beta-galactosidase (beta-gal), respectively. In parallel with the phospholamban phosphorylation, the decay kinetics of global Ca(2+) transients was slowed, accelerated, or unchanged, whereas spontaneous Ca(2+) spark activity was hyperactive, depressed, or unchanged in dominant-negative, constitutively active, or wild-type CaMKIIdelta(C) groups, respectively. When challenged by high extracellular Ca(2+), both wild-type and constitutively active CaMKIIdelta(C) protected the cells from store overload-induced Ca(2+) release, manifested by a approximately 60% suppression of Ca(2+) waves (at 2 to 20 mmol/L extracellular Ca(2+)) in spite of an elevated sarcoplasmic reticulum Ca(2+) content, whereas dominant-negative CaMKIIdelta(C) promoted Ca(2+) wave production (at 20 mmol/L Ca(2+)) with significantly depleted sarcoplasmic reticulum Ca(2+). Taken together, our data support the notion that CaMKIIdelta(C) negatively regulates RyR2 activity and spontaneous sarcoplasmic reticulum Ca(2+) release, thereby affording a negative feedback that stabilizes local and global Ca(2+)-induced Ca(2+) release in the heart. JF - Circulation research AU - Yang, Dongmei AU - Zhu, Wei-Zhong AU - Xiao, Bailong AU - Brochet, Didier X P AU - Chen, S R Wayne AU - Lakatta, Edward G AU - Xiao, Rui-Ping AU - Cheng, Heping AD - Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA. Y1 - 2007/02/16/ PY - 2007 DA - 2007 Feb 16 SP - 399 EP - 407 VL - 100 IS - 3 KW - Calmodulin KW - 0 KW - Isoenzymes KW - Recombinant Fusion Proteins KW - Ryanodine Receptor Calcium Release Channel KW - Prkcd protein, rat KW - EC 2.7.1.- KW - Protein Kinase C-delta KW - EC 2.7.11.13 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Calmodulin -- metabolism KW - Animals KW - Action Potentials KW - Recombinant Fusion Proteins -- physiology KW - Calcium -- metabolism KW - Models, Cardiovascular KW - Mutagenesis, Site-Directed KW - Rats KW - Rats, Sprague-Dawley KW - Cells, Cultured -- metabolism KW - Genes, Dominant KW - Isoenzymes -- physiology KW - Phosphorylation KW - Sarcoplasmic Reticulum -- metabolism KW - Adaptation, Physiological KW - Protein Processing, Post-Translational -- physiology KW - Calcium Signaling -- physiology KW - Myocardial Contraction -- physiology KW - Protein Kinase C-delta -- physiology KW - Ryanodine Receptor Calcium Release Channel -- metabolism KW - Protein Kinase C-delta -- genetics KW - Myocytes, Cardiac -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69018890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulation+research&rft.atitle=Ca2%2B%2Fcalmodulin+kinase+II-dependent+phosphorylation+of+ryanodine+receptors+suppresses+Ca2%2B+sparks+and+Ca2%2B+waves+in+cardiac+myocytes.&rft.au=Yang%2C+Dongmei%3BZhu%2C+Wei-Zhong%3BXiao%2C+Bailong%3BBrochet%2C+Didier+X+P%3BChen%2C+S+R+Wayne%3BLakatta%2C+Edward+G%3BXiao%2C+Rui-Ping%3BCheng%2C+Heping&rft.aulast=Yang&rft.aufirst=Dongmei&rft.date=2007-02-16&rft.volume=100&rft.issue=3&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=Circulation+research&rft.issn=1524-4571&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-27 N1 - Date created - 2007-02-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Circ Res. 2007 Feb 16;100(3):293-5 [17307966] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Osmotic stress-dependent repression is mediated by histone H3 phosphorylation and chromatin structure. AN - 69001146; 17158874 AB - Histone H3 phosphorylation has been linked to various environmental stress responses and specific chromatin structure. The role of H3 phosphorylation in the osmotic stress response was investigated on the mouse mammary tumor virus (MMTV) promoter in different chromatin configurations. Hormone-dependent transcription from the MMTV promoter is repressed by osmotic stress when the promoter is integrated and has a normal chromatin structure. However, when the MMTV promoter is transiently transfected, the chromatin structure is less organized, and hormone induction is not affected by osmotic stress. On the integrated MMTV promoter, phosphorylation of histone H3 serine 10 and 28 increases in response to osmotic stress, but the transient promoter shows no change. Hormone-dependent glucocorticoid receptor binding is reduced on the repressed promoter, and elevated H3 phosphorylation is temporally correlated with maximal MMTV repression Additionally, the protein kinase C inhibitor rottlerin, but not other kinase inhibitors, blocks both histone H3 phosphorylation and osmotic repression of MMTV transcription. Glucocorticoid receptor binding is inversely correlated with H3 phosphorylation, suggesting that displacement of the glucocorticoid receptor from the promoter is due to H3 phosphorylation and is the mechanism for the osmotic repression of hormone-dependent transcription. JF - The Journal of biological chemistry AU - Burkhart, Barbara A AU - Kennett, Sarah B AU - Archer, Trevor K AD - Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/02/16/ PY - 2007 DA - 2007 Feb 16 SP - 4400 EP - 4407 VL - 282 IS - 7 SN - 0021-9258, 0021-9258 KW - Acetophenones KW - 0 KW - Benzopyrans KW - Chromatin KW - Enzyme Inhibitors KW - Glucocorticoids KW - Histones KW - Receptors, Glucocorticoid KW - Dexamethasone KW - 7S5I7G3JQL KW - rottlerin KW - E29LP3ZMUH KW - Protein Kinase C KW - EC 2.7.11.13 KW - Index Medicus KW - Animals KW - Osmotic Pressure KW - Acetophenones -- pharmacology KW - Dexamethasone -- pharmacology KW - Humans KW - Cell Line, Tumor KW - Mice KW - Receptors, Glucocorticoid -- metabolism KW - Glucocorticoids -- pharmacology KW - Phosphorylation -- drug effects KW - Protein Kinase C -- metabolism KW - Protein Kinase C -- antagonists & inhibitors KW - Receptors, Glucocorticoid -- agonists KW - Benzopyrans -- pharmacology KW - Enzyme Inhibitors -- pharmacology KW - Protein Processing, Post-Translational -- drug effects KW - Mammary Tumor Virus, Mouse -- metabolism KW - Promoter Regions, Genetic KW - Chromatin -- metabolism KW - Protein Processing, Post-Translational -- genetics KW - Histones -- metabolism KW - Histones -- genetics KW - Chromatin -- genetics KW - Mammary Tumor Virus, Mouse -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69001146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Osmotic+stress-dependent+repression+is+mediated+by+histone+H3+phosphorylation+and+chromatin+structure.&rft.au=Burkhart%2C+Barbara+A%3BKennett%2C+Sarah+B%3BArcher%2C+Trevor+K&rft.aulast=Burkhart&rft.aufirst=Barbara&rft.date=2007-02-16&rft.volume=282&rft.issue=7&rft.spage=4400&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-26 N1 - Date created - 2007-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pattern of subclinical pulmonary dysfunctions in Parkinson's disease and the effect of levodopa. AN - 85396743; pmid-17230476 AB - We performed a detailed evaluation of pulmonary function in 53 patients with idiopathic Parkinson's disease (PD) who did not have symptoms of pulmonary or cardiac dysfunction. There was a significant pulmonary dysfunction of restrictive type which partially responded to levodopa. Compared to men, women were more severely affected. Pulmonary function assessment is recommended in PD, irrespective of severity of disease. JF - Movement disorders : official journal of the Movement Disorder Society AU - Pal, Pramod Kumar AU - Sathyaprabha, Talakad N AU - Tuhina, Prasad AU - Thennarasu, Kandavel AD - Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India. pal.pramod@rediffmail.com Y1 - 2007/02/15/ PY - 2007 DA - 2007 Feb 15 SP - 420 EP - 424 VL - 22 IS - 3 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - *Antiparkinson Agents: therapeutic use KW - Female KW - Humans KW - *Levodopa: therapeutic use KW - *Lung Diseases: drug therapy KW - Lung Diseases: etiology KW - Male KW - Middle Aged KW - Parkinson Disease: complications KW - *Parkinson Disease: drug therapy KW - Respiratory Function Tests: methods KW - Severity of Illness Index UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85396743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Pattern+of+subclinical+pulmonary+dysfunctions+in+Parkinson%27s+disease+and+the+effect+of+levodopa.&rft.au=Pal%2C+Pramod+Kumar%3BSathyaprabha%2C+Talakad+N%3BTuhina%2C+Prasad%3BThennarasu%2C+Kandavel&rft.aulast=Pal&rft.aufirst=Pramod&rft.date=2007-02-15&rft.volume=22&rft.issue=3&rft.spage=420&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - N-CoR pathway targeting induces glioblastoma derived cancer stem cell differentiation. AN - 70249920; 17312396 AB - Nuclear receptor corepressor (N-CoR) is a critical regulator of neural stem cell differentiation. Nuclear localization of N-CoR is a feature of undifferentiated neural stem cells and cytoplasmic translocation of N-CoR leads to astrocytic differentiation. Comparative proteomic analysis of microdissected glioblastoma multiforme (GBM) specimens and matched normal glial tissue reveals increased expression of N-CoR in GBM. In GBM primary cell cultures, tumor cells with nuclear localization of N-CoR demonstrate an undifferentiated phenotype, but are subject to astroglial differentiation upon exposure to agents promoting phosphorylation of N-CoR and its subsequent translocation to the cytoplasm. Treatment of glioma cell lines with a combination of retinoic acid and low-dose okadaic acid decreases the corepressor effect of N-CoR and has a striking synergistic effect on growth inhibition. The identification of N-CoR in GBM provides insights into the tumorigenesis process and supports the development of differentiation-based therapeutic strategies. JF - Cell cycle (Georgetown, Tex.) AU - Park, Deric M AU - Li, Jie AU - Okamoto, Hiroaki AU - Akeju, Oluwaseun AU - Kim, Stephanie H AU - Lubensky, Irina AU - Vortmeyer, Alexander AU - Dambrosia, James AU - Weil, Robert J AU - Oldfield, Edward H AU - Park, John K AU - Zhuang, Zhengping AD - Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2007/02/15/ PY - 2007 DA - 2007 Feb 15 SP - 467 EP - 470 VL - 6 IS - 4 KW - Biomarkers KW - 0 KW - NCOR1 protein, human KW - Nuclear Proteins KW - Nuclear Receptor Co-Repressor 1 KW - Repressor Proteins KW - Okadaic Acid KW - 1W21G5Q4N2 KW - Tretinoin KW - 5688UTC01R KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Tretinoin -- pharmacology KW - Humans KW - Tumor Cells, Cultured KW - Phosphorylation KW - Biomarkers -- analysis KW - Signal Transduction -- drug effects KW - Okadaic Acid -- pharmacology KW - Cell Differentiation -- drug effects KW - Drug Synergism KW - Okadaic Acid -- administration & dosage KW - Protein Transport KW - Nuclear Proteins -- analysis KW - Brain Neoplasms -- pathology KW - Glioblastoma -- pathology KW - Repressor Proteins -- physiology KW - Neoplastic Stem Cells -- pathology KW - Repressor Proteins -- metabolism KW - Brain Neoplasms -- metabolism KW - Repressor Proteins -- analysis KW - Nuclear Proteins -- metabolism KW - Nuclear Proteins -- physiology KW - Neoplastic Stem Cells -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70249920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+cycle+%28Georgetown%2C+Tex.%29&rft.atitle=N-CoR+pathway+targeting+induces+glioblastoma+derived+cancer+stem+cell+differentiation.&rft.au=Park%2C+Deric+M%3BLi%2C+Jie%3BOkamoto%2C+Hiroaki%3BAkeju%2C+Oluwaseun%3BKim%2C+Stephanie+H%3BLubensky%2C+Irina%3BVortmeyer%2C+Alexander%3BDambrosia%2C+James%3BWeil%2C+Robert+J%3BOldfield%2C+Edward+H%3BPark%2C+John+K%3BZhuang%2C+Zhengping&rft.aulast=Park&rft.aufirst=Deric&rft.date=2007-02-15&rft.volume=6&rft.issue=4&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Cell+cycle+%28Georgetown%2C+Tex.%29&rft.issn=1551-4005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-12 N1 - Date created - 2007-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nuclear factor-kappaB in development, prevention, and therapy of cancer. AN - 69041734; 17317814 AB - Nuclear factor-kappaB (NF-kappaB) is a signal transcription factor that has emerged as an important modulator of altered gene programs and malignant phenotype in development of cancer. Major carcinogens and oncogenic viruses induce NF-kappaB activation, and a variety of subsequent oncogenic events contribute to a progressive increase in constitutive NF-kappaB activation as an important common pathway in most forms of cancer. NF-kappaB target genes promote tumor cell proliferation, survival, migration, inflammation, and angiogenesis. Inhibition of NF-kappaB has been found to be an important mechanism of action of steroids, nonsteroidal anti-inflammatory drugs, and natural and synthetic compounds that show therapeutic and preventive activity. Newer agents targeting the proteasome, inhibitor-kappaB kinase, and other upstream kinases involved in NF-kappaB activation have shown anticancer activity in clinical or preclinical studies. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Van Waes, Carter AD - Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders and Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. vanwaesc@nidcd.nih.gov Y1 - 2007/02/15/ PY - 2007 DA - 2007 Feb 15 SP - 1076 EP - 1082 VL - 13 IS - 4 SN - 1078-0432, 1078-0432 KW - NF-kappa B KW - 0 KW - Index Medicus KW - Humans KW - Neoplasms -- therapy KW - Neoplasms -- genetics KW - NF-kappa B -- genetics KW - Neoplasms -- metabolism KW - NF-kappa B -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69041734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Nuclear+factor-kappaB+in+development%2C+prevention%2C+and+therapy+of+cancer.&rft.au=Van+Waes%2C+Carter&rft.aulast=Van+Waes&rft.aufirst=Carter&rft.date=2007-02-15&rft.volume=13&rft.issue=4&rft.spage=1076&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-18 N1 - Date created - 2007-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene expression profiling reveals potential biomarkers of human hepatocellular carcinoma. AN - 69039440; 17317821 AB - Hepatocellular carcinoma (HCC), a common cancer worldwide, has a dismal outcome partly due to the poor identification of early-stage HCC. Currently, one third of HCC patients present with low serum alpha-fetoprotein (AFP) levels, the only clinically available diagnostic marker for HCC. The aim of this study was to identify new diagnostic molecular markers for HCC, especially for individuals with low serum AFP. We used the microarray technique to determine the expression profiles of 218 HCC specimens from patients with either high or low serum AFP. From the microarray study, we selected five candidate genes (i.e., GPC3, PEG10, MDK, SERPINI1, and QP-C), which were overexpressed in HCCs. Using quantitative real-time PCR analyses, we validated the expression of these five genes in 50 AFP-normal and 8 AFP-positive HCC specimens and 36 cirrhotic noncancerous hepatic specimens, which include 52 independent specimens not used in microarray analysis. A significant increase in the expression of the five candidate genes could be detected in most of the HCC samples, including those with normal serum AFP and small tumors. GPC3, MDK, and SERPINI1 encode known serum proteins. Consistently, a significant increase in serum midkine, encoded by MDK, was associated with HCC patients, including those with normal serum AFP. Using prediction analysis of microarray, we showed that a combined score of these five genes can accurately classify noncancerous hepatic tissues (100%) and HCC (71%). We suggest that a diagnostic signature approach using a combined score of these five biomarkers rather than a single marker may improve the prediction accuracy of HCC patients, including those with normal serum AFP and smaller-sized tumors. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Jia, Hu-Liang AU - Ye, Qing-Hai AU - Qin, Lun-Xiu AU - Budhu, Anuradha AU - Forgues, Marshonna AU - Chen, Yidong AU - Liu, Yin-Kun AU - Sun, Hui-Chuan AU - Wang, Lu AU - Lu, Hong-Zhou AU - Shen, Fang AU - Tang, Zhao-You AU - Wang, Xin Wei AD - Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-4258, USA. Y1 - 2007/02/15/ PY - 2007 DA - 2007 Feb 15 SP - 1133 EP - 1139 VL - 13 IS - 4 SN - 1078-0432, 1078-0432 KW - Biomarkers, Tumor KW - 0 KW - Carrier Proteins KW - GPC3 protein, human KW - Glypicans KW - MDK protein, human KW - Nerve Growth Factors KW - Neuropeptides KW - PEG10 protein, human KW - Proteins KW - Serpins KW - alpha-Fetoproteins KW - neuroserpin KW - ubiquinone-binding proteins KW - Index Medicus KW - Glypicans -- genetics KW - Glypicans -- biosynthesis KW - Oligonucleotide Array Sequence Analysis KW - Carrier Proteins -- genetics KW - Humans KW - Serpins -- biosynthesis KW - Aged KW - Neuropeptides -- biosynthesis KW - Proteins -- genetics KW - Carrier Proteins -- biosynthesis KW - Gene Expression Profiling KW - Nerve Growth Factors -- biosynthesis KW - Nerve Growth Factors -- genetics KW - Polymerase Chain Reaction -- methods KW - Adult KW - Middle Aged KW - Adolescent KW - Serpins -- genetics KW - alpha-Fetoproteins -- metabolism KW - Female KW - Male KW - Neuropeptides -- genetics KW - Biomarkers, Tumor -- genetics KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - Carcinoma, Hepatocellular -- genetics KW - Biomarkers, Tumor -- biosynthesis KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69039440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Gene+expression+profiling+reveals+potential+biomarkers+of+human+hepatocellular+carcinoma.&rft.au=Laughon%2C+Barbara+E&rft.aulast=Laughon&rft.aufirst=Barbara&rft.date=2007-03-01&rft.volume=7&rft.issue=6&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=Current+Topics+in+Medicinal+Chemistry&rft.issn=15680266&rft_id=info:doi/10.2174%2F156802607780059736 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-18 N1 - Date created - 2007-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inhibition of CCAAT/enhancer binding protein family DNA binding in mouse epidermis prevents and regresses papillomas. AN - 69020296; 17308129 AB - The CCAAT/enhancer binding proteins (C/EBP) are a family of B-ZIP DNA binding proteins that act as transcription factors to regulate growth and differentiation of many cell types, including keratinocytes. To examine the consequences of inhibiting the C/EBP family of transcription factors in skin, we generated transgenic mice that use the tetracycline system to conditionally express A-C/EBP, a dominant negative that inhibits the DNA binding of C/EBP family members. We expressed A-C/EBP in the basal layer of the skin epidermis during a two-step skin carcinogenesis protocol. A-C/EBP expression caused hyperplasia of the basal epidermis and increased apoptosis in the suprabasal epidermis. The mice developed fewer papillomas and had systemic hair loss. A-C/EBP expression caused C/EBPbeta protein to disappear whereas C/EBPalpha, p53, Bax, and caspase-3 protein levels were dramatically up-regulated in the suprabasal layer. Primary keratinocytes recapitulate the A-C/EBP induction of cell growth and increase in p53 protein. A-C/EBP expression after papilloma development caused the papillomas to regress with an associated increase in apoptosis and up-regulation of p53 protein. Furthermore, A-C/EBP-expressing mice heterozygous for p53 were more susceptible to papilloma formation, suggesting that the suppression of papilloma formation has a p53-dependent mechanism. These results implicate DNA binding of C/EBP family members as a potential molecular therapeutic target. JF - Cancer research AU - Oh, Won Jun AU - Rishi, Vikas AU - Orosz, Andras AU - Gerdes, Michael J AU - Vinson, Charles AD - Laboratory of Metabolism, National Cancer Institute, Center for Cancer Research/NIH, Bethesda, MD 20892, USA. Y1 - 2007/02/15/ PY - 2007 DA - 2007 Feb 15 SP - 1867 EP - 1876 VL - 67 IS - 4 SN - 0008-5472, 0008-5472 KW - CCAAT-Enhancer-Binding Proteins KW - 0 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Animals KW - Cell Growth Processes -- physiology KW - Skin -- metabolism KW - Apoptosis -- physiology KW - Skin -- pathology KW - Keratinocytes -- cytology KW - Mice KW - Keratinocytes -- metabolism KW - Mice, Transgenic KW - CCAAT-Enhancer-Binding Proteins -- biosynthesis KW - Papilloma -- prevention & control KW - Papilloma -- pathology KW - DNA -- metabolism KW - CCAAT-Enhancer-Binding Proteins -- metabolism KW - Skin Neoplasms -- pathology KW - CCAAT-Enhancer-Binding Proteins -- antagonists & inhibitors KW - CCAAT-Enhancer-Binding Proteins -- genetics KW - Skin Neoplasms -- prevention & control KW - Skin Neoplasms -- metabolism KW - Papilloma -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69020296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Inhibition+of+CCAAT%2Fenhancer+binding+protein+family+DNA+binding+in+mouse+epidermis+prevents+and+regresses+papillomas.&rft.au=Oh%2C+Won+Jun%3BRishi%2C+Vikas%3BOrosz%2C+Andras%3BGerdes%2C+Michael+J%3BVinson%2C+Charles&rft.aulast=Oh&rft.aufirst=Won&rft.date=2007-02-15&rft.volume=67&rft.issue=4&rft.spage=1867&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-15 N1 - Date created - 2007-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pesticide exposure and self-reported Parkinson's disease in the agricultural health study. AN - 68984587; 17116648 AB - Previous studies based on limited exposure assessment have suggested that Parkinson's disease (PD) is associated with pesticide exposure. The authors used data obtained from licensed private pesticide applicators and spouses participating in the Agricultural Health Study to evaluate the relation of self-reported PD to pesticide exposure. Cohort members, who were enrolled in 1993-1997, provided detailed information on lifetime pesticide use. At follow-up in 1999-2003, 68% of the cohort was interviewed. Cases were defined as participants who reported physician-diagnosed PD at enrollment (prevalent cases, n = 83) or follow-up (incident cases, n = 78). Cases were compared with cohort members who did not report PD (n = 79,557 at enrollment and n = 55,931 at follow-up). Incident PD was associated with cumulative days of pesticide use at enrollment (for highest quartile vs. lowest, odds ratio (OR) = 2.3, 95% confidence interval: 1.2, 4.5; p-trend = 0.009), with personally applying pesticides more than half the time (OR = 1.9, 95% confidence interval: 0.7, 4.7), and with some specific pesticides (ORs > or = 1.4). Prevalent PD was not associated with overall pesticide use. This study suggests that exposure to certain pesticides may increase PD risk. Findings for specific chemicals may provide fruitful leads for further investigation. JF - American journal of epidemiology AU - Kamel, F AU - Tanner, Cm AU - Umbach, Dm AU - Hoppin, Ja AU - Alavanja, McR AU - Blair, A AU - Comyns, K AU - Goldman, Sm AU - Korell, M AU - Langston, Jw AU - Ross, Gw AU - Sandler, Dp AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. kamel@mail.nih.gov Y1 - 2007/02/15/ PY - 2007 DA - 2007 Feb 15 SP - 364 EP - 374 VL - 165 IS - 4 SN - 0002-9262, 0002-9262 KW - Pesticides KW - 0 KW - Index Medicus KW - Humans KW - Retrospective Studies KW - Aged KW - Child KW - North Carolina -- epidemiology KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Incidence KW - Follow-Up Studies KW - Middle Aged KW - Adolescent KW - Female KW - Iowa -- epidemiology KW - Male KW - Prevalence KW - Agriculture KW - Parkinson Disease, Secondary -- chemically induced KW - Parkinson Disease, Secondary -- epidemiology KW - Health Surveys KW - Environmental Exposure -- adverse effects KW - Pesticides -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68984587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Pesticide+exposure+and+self-reported+Parkinson%27s+disease+in+the+agricultural+health+study.&rft.au=Kamel%2C+F%3BTanner%2C+Cm%3BUmbach%2C+Dm%3BHoppin%2C+Ja%3BAlavanja%2C+McR%3BBlair%2C+A%3BComyns%2C+K%3BGoldman%2C+Sm%3BKorell%2C+M%3BLangston%2C+Jw%3BRoss%2C+Gw%3BSandler%2C+Dp&rft.aulast=Kamel&rft.aufirst=F&rft.date=2007-02-15&rft.volume=165&rft.issue=4&rft.spage=364&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-13 N1 - Date created - 2007-02-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic mechanisms of susceptibility to oxidative lung injury in mice. AN - 68974066; 17275675 AB - Genetic background is a known predisposing risk factor for many acute and chronic pulmonary disorders and responses to environmental oxidants. Variation in lung injury responses to oxidative stimuli such as ozone, particles, hyperoxia, and chemotherapeutic agents between genetically standardized inbred mouse strains has been demonstrated. In this review, we discuss quantitative trait loci (QTLs) which contain candidate genes that confer differential susceptibility to oxidative stimuli between strains in mouse models of airway toxicity and disease. We addressed multiple inflammatory, immunity, and antioxidant genes identified as candidate genetic determinants following these strategies, which include tumor necrosis factor (Tnf), toll-like receptor 4 (Tlr4), and the transcription factor NF-E2, related factor 2 (Nrf2). Mice with targeted deletion of these and related genes have provided initial proof of concept for their importance in the respective models. Interestingly, a few regions of the genome appear to have important roles in determining susceptibility to a number of stimuli which may suggest common genetic mechanisms in mice. Though more complete examination of functional association is required, results have potential implications for the role of these candidate genes in the pathogenesis of human pulmonary diseases including asthma, acute respiratory distress syndrome (ARDS), idiopathic pulmonary fibrosis (IPF), and emphysema. JF - Free radical biology & medicine AU - Cho, Hye-Youn AU - Kleeberger, Steven R AD - Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. cho2@niehs.nih.gov Y1 - 2007/02/15/ PY - 2007 DA - 2007 Feb 15 SP - 433 EP - 445 VL - 42 IS - 4 SN - 0891-5849, 0891-5849 KW - Index Medicus KW - Animals KW - Base Sequence KW - Mice KW - Species Specificity KW - Lung Diseases -- genetics KW - Oxidative Stress KW - Genetic Predisposition to Disease UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68974066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Genetic+mechanisms+of+susceptibility+to+oxidative+lung+injury+in+mice.&rft.au=Cho%2C+Hye-Youn%3BKleeberger%2C+Steven+R&rft.aulast=Cho&rft.aufirst=Hye-Youn&rft.date=2007-02-15&rft.volume=42&rft.issue=4&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=08915849&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-26 N1 - Date created - 2007-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bacillus anthracis edema and lethal toxin have different hemodynamic effects but function together to worsen shock and outcome in a rat model. AN - 68925042; 17230417 AB - To better define the contribution of edema toxins (ETx) and lethal toxins (LeTx) to shock with Bacillus anthracis, recombinant preparations of each were investigated alone or together in rats. Lethal dose ranges (0%-100% lethality) of ETx (200-800 microg/kg as a 24-h infusion) were higher than those of LeTx (12.5-200 microg/kg) (P<.0001). However, compared with LeTx, similarly lethal ETx doses produced earlier and greater reductions in mean blood pressure (MBP) and increased, rather than decreased, heart rate (HR) (P<.05 for all). Combining either similar weight or lethal doses of ETx and LeTx increased the hazard ratio for death (log +/- standard error) similar to the sum calculated with the toxin's effects alone (2.6+/-1.1 observed vs. 2.9+/-1.0 calculated for similar weight and 3.1+/-1.0 vs. 3.9+/-1.5 for similar lethal doses; P=.5 for both). Early (< or =10 h) and late during infusion, ETx and LeTx together also altered MBP and HR in patterns consistent with the sum of their individual effects. ETx was approximately 10 times less lethal than LeTx but produced greater hypotension and added to the latter's harmful effects. These findings suggest that it may be appropriate for antitoxin therapies for B. anthracis to target both ETx and LeTx. JF - The Journal of infectious diseases AU - Cui, Xizhong AU - Li, Yan AU - Li, Xuemei AU - Laird, Michael W AU - Subramanian, Mani AU - Moayeri, Mahtab AU - Leppla, Stephen H AU - Fitz, Yvonne AU - Su, Junwu AU - Sherer, Kevin AU - Eichacker, Peter Q AD - Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/02/15/ PY - 2007 DA - 2007 Feb 15 SP - 572 EP - 580 VL - 195 IS - 4 SN - 0022-1899, 0022-1899 KW - Antigens, Bacterial KW - 0 KW - Bacterial Toxins KW - Cytokines KW - Hemoglobins KW - Recombinant Proteins KW - Virulence Factors KW - anthrax toxin KW - Nitric Oxide KW - 31C4KY9ESH KW - Abridged Index Medicus KW - Index Medicus KW - Recombinant Proteins -- toxicity KW - Rats KW - Cytokines -- blood KW - Animals KW - Rats, Sprague-Dawley KW - Hemoglobins -- analysis KW - Heart Rate KW - Blood Pressure KW - Nitric Oxide -- blood KW - Disease Models, Animal KW - Time Factors KW - Leukocyte Count KW - Survival Analysis KW - Antigens, Bacterial -- toxicity KW - Shock -- microbiology KW - Anthrax -- physiopathology KW - Virulence Factors -- toxicity KW - Bacillus anthracis -- pathogenicity KW - Anthrax -- pathology KW - Bacterial Toxins -- toxicity KW - Anthrax -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68925042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=Bacillus+anthracis+edema+and+lethal+toxin+have+different+hemodynamic+effects+but+function+together+to+worsen+shock+and+outcome+in+a+rat+model.&rft.au=Cui%2C+Xizhong%3BLi%2C+Yan%3BLi%2C+Xuemei%3BLaird%2C+Michael+W%3BSubramanian%2C+Mani%3BMoayeri%2C+Mahtab%3BLeppla%2C+Stephen+H%3BFitz%2C+Yvonne%3BSu%2C+Junwu%3BSherer%2C+Kevin%3BEichacker%2C+Peter+Q&rft.aulast=Cui&rft.aufirst=Xizhong&rft.date=2007-02-15&rft.volume=195&rft.issue=4&rft.spage=572&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-19 N1 - Date created - 2007-01-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Infect Dis. 2007 Feb 15;195(4):471-3 [17230405] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inflammation and IGF-I activate the Akt pathway in breast cancer. AN - 68387809; 17096325 AB - Akt signaling may promote breast cancer progression and poor disease outcome. We hypothesized that serum insulin-like growth factor I (IGF-I) and a proinflammatory tumor environment induce phosphorylation of Akt and downstream targets of Akt in breast cancer. We studied the relationship between Akt pathway activation, IGF-I and markers of inflammation, e.g., nitric oxide synthase-2 (NOS2), cyclooxygenase-2 (COX2) and tumor phagocyte density, in 248 breast tumors. We also examined the association of Akt phosphorylation with breast cancer survival. We observed that phosphorylation of Akt, BAD and caspase-9 correlated strongly with the expression of the 2 proinflammatory enzymes, NOS2 and COX2, in breast tumors (p < 0.001; Spearman rank correlation). Both NOS2 and COX2 expression were independently associated with Akt phosphorylation in the multivariate analysis. Serum IGF-I concentrations and the IGF-I/IGFBP3 ratio correlated with Akt phosphorylation at Thr308 and Ser473 in breast tumors (p 90-fold, whereas TNF-alpha-mediated activation was inhibited by >30%. A reporter gene assay showed that HU and IL-6 synergized to activate HIV promoter activity via the Sp1 binding site. Electrophoretic mobility shift and supershift assays revealed increased binding of the Sp1 and Sp3 transcription factors to this region. Western blot analysis showed that HU and IL-6 co-stimulation resulted in increased levels of Sp1 and Sp3 proteins. In contrast, treatment with HU plus TNF-alpha down-regulated the expression of NF-kappaB. These findings suggest that Sp1/Sp3 is involved in controlling the HU/IL-6-induced reactivation of HIV-1 in latently infected cells. JF - The Journal of biological chemistry AU - Oguariri, Raphael M AU - Brann, Terrence W AU - Imamichi, Tomozumi AD - Laboratory of Human Retrovirology, Clinical Services Program, Science Applications International Corporation-Frederick Inc., NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702, USA. Y1 - 2007/02/09/ PY - 2007 DA - 2007 Feb 09 SP - 3594 EP - 3604 VL - 282 IS - 6 SN - 0021-9258, 0021-9258 KW - Interleukin-6 KW - 0 KW - Sp1 Transcription Factor KW - Sp3 Transcription Factor KW - 148710-94-5 KW - Hydroxyurea KW - X6Q56QN5QC KW - Index Medicus KW - Virus Latency -- physiology KW - Virus Replication -- drug effects KW - Humans KW - Virus Latency -- drug effects KW - Cell Line, Tumor KW - Virus Replication -- physiology KW - Drug Synergism KW - Virus Activation -- physiology KW - Virus Activation -- drug effects KW - Interleukin-6 -- physiology KW - Sp1 Transcription Factor -- physiology KW - Monocytes -- metabolism KW - Monocytes -- drug effects KW - Hydroxyurea -- pharmacology KW - Monocytes -- virology KW - HIV-1 -- physiology KW - Sp3 Transcription Factor -- physiology KW - HIV-1 -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68974660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Hydroxyurea+and+interleukin-6+synergistically+reactivate+HIV-1+replication+in+a+latently+infected+promonocytic+cell+line+via+SP1%2FSP3+transcription+factors.&rft.au=Oguariri%2C+Raphael+M%3BBrann%2C+Terrence+W%3BImamichi%2C+Tomozumi&rft.aulast=Oguariri&rft.aufirst=Raphael&rft.date=2007-02-09&rft.volume=282&rft.issue=6&rft.spage=3594&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-23 N1 - Date created - 2007-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The inner loop of tetraspanins CD82 and CD81 mediates interactions with human T cell lymphotrophic virus type 1 Gag protein. AN - 68974447; 17166843 AB - The tetraspanin superfamily proteins play important roles in organizing membrane protein complexes, modulating integrin function, and controlling T cell adhesion. Tetraspanins such as CD82 contain two extracellular loops with its N terminus, C terminus, and inner loop exposed to the cytoplasm. The matrix (MA) domain of human T cell lymphotrophic virus, type 1 (HTLV-1), Gag interacts with the cytoplasmic face of the plasma membrane and is concentrated at tetraspanin-enriched microdomains. To understand the basis of this association, we generated site-directed mutations in the various domains of CD82 and used coimmunoprecipitation and colocalization approaches to examine interactions with HTLV-1 MA. The large extracellular loop of CD82, which is important for interactions with integrins, was not required for the association with HTLV-1 MA. The cytoplasmic N terminus and C terminus of CD82 were also dispensable for CD82-MA interactions. In contrast, mutations of conserved amino acids in the inner loop of CD82 or of palmitoylated cysteines that flank the inner loop diminished CD82 association with MA. HTLV-1 MA also interacted with the inner loop of CD81. Thus, association of HTLV-1 Gag with tetraspanin-enriched microdomains is mediated by the inner loops of CD81 and CD82. JF - The Journal of biological chemistry AU - Mazurov, Dmitriy AU - Heidecker, Gisela AU - Derse, David AD - HIV Drug Resistance Program, NCI-Frederick, Frederick, Maryland 21702-1201, USA. Y1 - 2007/02/09/ PY - 2007 DA - 2007 Feb 09 SP - 3896 EP - 3903 VL - 282 IS - 6 SN - 0021-9258, 0021-9258 KW - Antigens, CD KW - 0 KW - Antigens, CD81 KW - Antigens, CD82 KW - CD81 protein, human KW - CD82 protein, human KW - Gene Products, gag KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Protein Structure, Tertiary -- genetics KW - HeLa Cells KW - Humans KW - Membrane Microdomains -- physiology KW - Jurkat Cells KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Membrane Microdomains -- genetics KW - Membrane Microdomains -- chemistry KW - Cell Line KW - Human T-lymphotropic virus 1 -- physiology KW - Antigens, CD82 -- genetics KW - Human T-lymphotropic virus 1 -- genetics KW - Antigens, CD -- physiology KW - Human T-lymphotropic virus 1 -- chemistry KW - Antigens, CD82 -- chemistry KW - Antigens, CD82 -- physiology KW - Antigens, CD -- chemistry KW - Antigens, CD -- genetics KW - Gene Products, gag -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68974447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=The+inner+loop+of+tetraspanins+CD82+and+CD81+mediates+interactions+with+human+T+cell+lymphotrophic+virus+type+1+Gag+protein.&rft.au=Mazurov%2C+Dmitriy%3BHeidecker%2C+Gisela%3BDerse%2C+David&rft.aulast=Mazurov&rft.aufirst=Dmitriy&rft.date=2007-02-09&rft.volume=282&rft.issue=6&rft.spage=3896&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-23 N1 - Date created - 2007-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival. AN - 68973905; 17148450 AB - Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase consisting of two isoforms, alpha and beta. The activities of GSK-3 are regulated negatively by serine phosphorylation but positively by tyrosine phosphorylation. GSK-3 inactivation has been proposed as a mechanism to promote neuronal survival. We used GSK-3 isoform-specific small interfering RNAs, dominant-negative mutants, or pharmacological inhibitors to search for functions of the two GSK-3 isoforms in regulating neuronal survival in cultured cortical neurons in response to glutamate insult or during neuronal maturation/aging. Surprisingly, RNA interference-induced depletion of either isoform was sufficient to block glutamate-induced excitotoxicity, and the resulting neuroprotection was associated with enhanced N-terminal serine phosphorylation in both GSK-3 isoforms. However, GSK-3beta depletion was more effective than GSK-3alpha depletion in suppressing spontaneous neuronal death in extended culture. This phenomenon is likely due to selective and robust inhibition of GSK-3beta activation resulting from GSK-3beta Ser9 dephosphorylation during the course of spontaneous neuronal death. GSK-3alpha silencing resulted in reduced tyrosine phosphorylation of GSK-3beta, suggesting that tyrosine phosphorylation is also a critical autoregulatory event. Interestingly, GSK-3 inhibitors caused a rapid and long-lasting increase in GSK-3alpha Ser21 phosphorylation levels, followed by a delayed increase in GSK-3beta Ser9 phosphorylation and a decrease in GSK-3alpha Tyr279 and GSK-3beta Tyr216 phosphorylation, thus implying additional levels of GSK-3 autoregulation. Taken together, our results underscore important similarities and dissimilarities of GSK-3alpha and GSK-3beta in the roles of cell survival as well as their distinct modes of regulation. The development of GSK-3 isoform-specific inhibitors seems to be warranted for treating GSK-3-mediated pathology. JF - The Journal of biological chemistry AU - Liang, Min-Huei AU - Chuang, De-Maw AD - Molecular Neurobiology Section, National Institute of Mental Health, Bethesda, Maryland 20892-1363, USA. Y1 - 2007/02/09/ PY - 2007 DA - 2007 Feb 09 SP - 3904 EP - 3917 VL - 282 IS - 6 SN - 0021-9258, 0021-9258 KW - Isoenzymes KW - 0 KW - RNA, Small Interfering KW - Glutamic Acid KW - 3KX376GY7L KW - Glycogen Synthase Kinase 3 beta KW - EC 2.7.11.1 KW - Gsk3b protein, rat KW - Glycogen Synthase Kinase 3 KW - EC 2.7.11.26 KW - glycogen synthase kinase 3 alpha KW - Index Medicus KW - Animals KW - Cerebral Cortex -- cytology KW - Cerebral Cortex -- drug effects KW - Cell Survival -- genetics KW - Cerebral Cortex -- enzymology KW - Gene Silencing KW - Isoenzymes -- genetics KW - Isoenzymes -- metabolism KW - Phosphorylation -- drug effects KW - Rats KW - Glutamic Acid -- toxicity KW - Isoenzymes -- physiology KW - Cell Survival -- drug effects KW - Transfection KW - Cells, Cultured KW - RNA, Small Interfering -- pharmacology KW - Organ Culture Techniques KW - Mutation KW - Cell Survival -- physiology KW - Glycogen Synthase Kinase 3 -- physiology KW - Glycogen Synthase Kinase 3 -- genetics KW - Neurons -- drug effects KW - Neurons -- cytology KW - Neurons -- enzymology KW - Glycogen Synthase Kinase 3 -- metabolism KW - Glycogen Synthase Kinase 3 -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68973905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Regulation+and+function+of+glycogen+synthase+kinase-3+isoforms+in+neuronal+survival.&rft.au=Liang%2C+Min-Huei%3BChuang%2C+De-Maw&rft.aulast=Liang&rft.aufirst=Min-Huei&rft.date=2007-02-09&rft.volume=282&rft.issue=6&rft.spage=3904&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-23 N1 - Date created - 2007-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Smoking is associated with increased telomerase activity in short-term cultures of human bronchial epithelial cells. AN - 68377321; 16517060 AB - Telomerase plays an important role in the maintenance of telomere ends in normal and tumor cells and ectopic expression can immortalize human bronchial epithelial (HBE) cells. We assessed telomerase activation, growth properties and methylation status in the hTERT promoter in a panel of HBE cell cultures in relation to smoking and previous lung cancer history. HBE cells were obtained from a total of 26 subjects, six of whom were lifelong non-smokers, while 20 subjects had a smoking history, including seven who had lung carcinoma. Telomerase activity was determined using the telomeric repeat amplification protocol (TRAP). Maximum passage number and time to senescence were also determined through extended culturing. The distribution of the telomerase activity between ever-smokers and never-smokers was significantly different (P=0.03, F-test), and there was a strong correlation between telomerase activity and the number of pack-years smoked (P=0.0012, F-test for slope). A small difference in telomerase activity was observed according to lung cancer status (P=0.02, F-test). Telomerase activity was not correlated with maximum passage number after extended culturing or with time to senescence. None of the HBE cultures demonstrated methylation of the hTERT promoter. Our results indicate an association between tobacco carcinogen exposure and telomerase activity in normal bronchial epithelium, although a causative role of tobacco smoking in the (re)activation of telomerase can not be proven. An increase in telomerase activity in normal bronchial epithelium might extend the lifespan of cells at risk for malignant transformation, and thus contribute to lung carcinogenesis. JF - Cancer letters AU - Yim, Hyeon Woo AU - Slebos, Robbert J C AU - Randell, Scott H AU - Umbach, David M AU - Parsons, Alden M AU - Rivera, M Patricia AU - Detterbeck, Frank C AU - Taylor, Jack A AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2007/02/08/ PY - 2007 DA - 2007 Feb 08 SP - 24 EP - 33 VL - 246 IS - 1-2 SN - 0304-3835, 0304-3835 KW - Telomerase KW - EC 2.7.7.49 KW - Index Medicus KW - Lung Neoplasms -- enzymology KW - Humans KW - Aged KW - Bronchi -- enzymology KW - Child KW - Bronchi -- pathology KW - Cell Proliferation KW - Promoter Regions, Genetic KW - Tumor Cells, Cultured KW - DNA Methylation KW - Aged, 80 and over KW - Cell Aging KW - Cells, Cultured KW - Polymerase Chain Reaction -- methods KW - Adult KW - Lung Neoplasms -- genetics KW - Cell Culture Techniques -- methods KW - Middle Aged KW - Bronchi -- metabolism KW - Adolescent KW - Time Factors KW - Male KW - Female KW - Lung Neoplasms -- pathology KW - Epithelial Cells -- metabolism KW - Smoking KW - Epithelial Cells -- enzymology KW - Epithelial Cells -- pathology KW - Telomerase -- genetics KW - Telomerase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68377321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Smoking+is+associated+with+increased+telomerase+activity+in+short-term+cultures+of+human+bronchial+epithelial+cells.&rft.au=Yim%2C+Hyeon+Woo%3BSlebos%2C+Robbert+J+C%3BRandell%2C+Scott+H%3BUmbach%2C+David+M%3BParsons%2C+Alden+M%3BRivera%2C+M+Patricia%3BDetterbeck%2C+Frank+C%3BTaylor%2C+Jack+A&rft.aulast=Yim&rft.aufirst=Hyeon&rft.date=2007-02-08&rft.volume=246&rft.issue=1-2&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-19 N1 - Date created - 2006-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Symptom Cluster of Fatigue and Depression in HIV/AIDS AN - 61398791; 200800677 AB - Fatigue and depression are among the most frequently rated symptoms of people with HIV/AIDS. This study aimed: (1) to describe severity of fatigue and depression in an outpatient sample (n = 372) of men and women with HIV/AIDS, (2) to evaluate sensitivity and discriminant validity for two fatigue and three depression scales and (3) to investigate whether fatigue and depression are conceptually distinct concepts or reciprocally dependent. This was a secondary analysis of a descriptive, cross-sectional study with convenience sampling. Fatigue was assessed with the fatigue factor score of the revised Sign and Symptom Checklist HIV (SSC-HIVrev), and the fatigue scale of the Self-Care Symptom Management for Living with HIV/AIDS Scale SCSMS-F). Depression was assessed with the depression factor score of the SSC-HIVrev, the depression scale of the SCSMC-D and the Center for Epidemiologic Studies Depression Scale (CES-D). Most of the participants were male (67%), with a mean age of 39.9 years, and of African American decent (73%). Dependent on the instrument, the average fatigue severity was moderate and the average depression severity was moderate to severe. Women experienced higher fatigue and depression severity scores than men. The scores on the same instruments for fatigue and depression showed significant correlations (SSC-HIVrev fatigue and depression r = 0.62; SCSMS fatigue and depression r = 0.64), indicating that both concepts are closely related. Patients seeking help for fatigue and/or depression should always be evaluated for both symptoms. Future research is needed to identify dimensions in different fatigue and depression scales in order to differentiate the impact of both symptoms on people living with HIV/AIDS. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Journal of Prevention & Intervention in the Community AU - Voss, Joachim AU - Portillo, Carmen AU - Holzemer, William AU - Dodd, Marylin AD - RN, National Institutes of Health, National Institute of Neurological Disorders and Stroke, Bethesda, MD, 20892-1382 Y1 - 2007/02/08/ PY - 2007 DA - 2007 Feb 08 SP - 19 EP - 34 PB - Haworth Press, Binghamton NY VL - 33 IS - 1-2 SN - 1085-2352, 1085-2352 KW - Help Seeking Behavior KW - Black Americans KW - Fatigue KW - Depression (Psychology) KW - Scales KW - Acquired Immune Deficiency Syndrome KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61398791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Prevention+%26+Intervention+in+the+Community&rft.atitle=Symptom+Cluster+of+Fatigue+and+Depression+in+HIV%2FAIDS&rft.au=Voss%2C+Joachim%3BPortillo%2C+Carmen%3BHolzemer%2C+William%3BDodd%2C+Marylin&rft.aulast=Voss&rft.aufirst=Joachim&rft.date=2007-02-08&rft.volume=33&rft.issue=1-2&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Journal+of+Prevention+%26+Intervention+in+the+Community&rft.issn=10852352&rft_id=info:doi/10.1300%2FJ005v33n01_03 LA - English DB - Social Services Abstracts N1 - Date revised - 2008-02-04 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Depression (Psychology); Fatigue; Acquired Immune Deficiency Syndrome; Black Americans; Help Seeking Behavior; Scales DO - http://dx.doi.org/10.1300/J005v33n01_03 ER - TY - CPAPER T1 - Standard Gradient Echo (GRE) is Far Superior to Other Susceptibility-Weighted MR Sequences for Identifying Intracranial Hemorrhage T2 - 2007 International Stroke Conference AN - 40526253; 4519624 JF - 2007 International Stroke Conference AU - Fifi, Johanna T AU - Butman, John A AU - Warach, Steven AU - Luby, Marie AU - Chalela, Julio AU - Saver, Jeffrey L AU - Kidwell, Chelsea S Y1 - 2007/02/07/ PY - 2007 DA - 2007 Feb 07 KW - Hemorrhage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40526253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Stroke+Conference&rft.atitle=Standard+Gradient+Echo+%28GRE%29+is+Far+Superior+to+Other+Susceptibility-Weighted+MR+Sequences+for+Identifying+Intracranial+Hemorrhage&rft.au=Fifi%2C+Johanna+T%3BButman%2C+John+A%3BWarach%2C+Steven%3BLuby%2C+Marie%3BChalela%2C+Julio%3BSaver%2C+Jeffrey+L%3BKidwell%2C+Chelsea+S&rft.aulast=Fifi&rft.aufirst=Johanna&rft.date=2007-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Stroke+Conference&rft.issn=&rft_id=info:doi/ L2 - http://strokeconference.americanheart.org/portal/strokeconference/sc/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Second Cancer Incidence and Cause-Specific Mortality Among 3104 Patients With Hairy Cell Leukemia: A Population-Based Study AN - 19586294; 7289326 AB - BACKGROUND: The introduction of new treatments for hairy cell leukemia has resulted in improved patient survival but also engendered increasing concern about the possibility of excess second cancers. The available evidence is conflicting, with most risk estimates based on sparse numbers. To our knowledge, no study has evaluated cause-specific mortality in patients with hairy cell leukemia. METHODS: We quantified second cancer incidence and cause-specific mortality among 3104 two-month survivors of hairy cell leukemia who were reported to 16 population-based registries in the Surveillance, Epidemiology and End Results (SEER) Program between 1973 and 2002. Standardized incidence ratios (SIRs) and standardized mortality ratios (SMRs) were used to quantify the risk of second cancers and causes of death, respectively. The cumulative probability of a second cancer among survivors of hairy cell leukemia was calculated using a competing risk model. All statistical tests were two-sided. RESULTS: Mean follow-up of hairy cell leukemia survivors was 6.5 years (range, 2 months-29.3 years). Second cancer risk was statistically significantly elevated (SIR = 1.24, 95% confidence interval [CI] = 1.11 to 1.37) compared with the general population. Survivors had statistically significantly higher risks of Hodgkin lymphoma (SIR = 6.61, 95% CI = 2.13 to 15.42), non-Hodgkin lymphoma (SIR = 5.03, 95% CI = 3.77 to 6.58), and thyroid cancer (SIR = 3.56, 95% CI = 1.30 to 7.74) and a lower risk of lung cancer (SIR = 0.63, 95% CI = 0.42 to 0.90). The cumulative probability of all second cancers was estimated to be 31.9% (95% CI = 26.2 to 37.6) 25 years after hairy cell leukemia diagnosis. Among 10 000 hairy cell leukemia patients, a total excess of about 34 cancers, including 21 non-Hodgkin lymphomas, 2 Hodgkin lymphomas, and 7 solid tumors (including 2 thyroid cancers), might be observed per year. Deaths due to solid tumors were not elevated compared with the general population (SMR = 0.9), and there were statistically significant deficits in mortality due to both cardiovascular (SMR = 0.67, 95% CI = 0.56 to 0.80) and cerebrovascular (SMR = 0.61, 95% CI = 0.38 to 0.93) disease. CONCLUSIONS: Patients with hairy cell leukemia are at increased risk of Hodgkin lymphoma, non-Hodgkin lymphoma, and thyroid cancer. The decrease in lung cancer incidence and smoking-associated vascular mortality may reflect an inverse association of tobacco use with hairy cell leukemia. Future studies should address the roles of immunologic impairment inherent to hairy cell leukemia, treatment modalities, and other factors as codeterminants of morbidity and mortality in hairy cell leukemia survivors. JF - Journal of the National Cancer Institute AU - Hisada, Michie AU - Chen, Bingshu E AU - Jaffe, Elaine S AU - Travis, Lois B AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (MH, BEC, LBT) Y1 - 2007/02/07/ PY - 2007 DA - 2007 Feb 07 SP - 215 EP - 222 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 3 SN - 0027-8874, 0027-8874 KW - Risk Abstracts; CSA Neurosciences Abstracts KW - Risk assessment KW - Cell survival KW - Mortality KW - Hodgkin's disease KW - Solid tumors KW - Thyroid KW - Statistical analysis KW - Population studies KW - Morbidity KW - Leukemia KW - Epidemiology KW - Risk factors KW - thyroid cancer KW - Tobacco KW - survival KW - lymphoma KW - Hairy cell leukemia KW - Lung cancer KW - Vascular system KW - R2 23060:Medical and environmental health KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19586294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Second+Cancer+Incidence+and+Cause-Specific+Mortality+Among+3104+Patients+With+Hairy+Cell+Leukemia%3A+A+Population-Based+Study&rft.au=Hisada%2C+Michie%3BChen%2C+Bingshu+E%3BJaffe%2C+Elaine+S%3BTravis%2C+Lois+B&rft.aulast=Hisada&rft.aufirst=Michie&rft.date=2007-02-07&rft.volume=99&rft.issue=3&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell survival; Risk assessment; Mortality; Hodgkin's disease; Solid tumors; Statistical analysis; Population studies; Morbidity; Epidemiology; Risk factors; thyroid cancer; Tobacco; Hairy cell leukemia; Vascular system; Lung cancer; Leukemia; Thyroid; survival; lymphoma ER - TY - CPAPER T1 - Deoxyuracils in Immunoglobulin Genes from Germinal Center B Cells T2 - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AN - 40534110; 4522435 JF - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AU - Gearhart, Patricia J Y1 - 2007/02/06/ PY - 2007 DA - 2007 Feb 06 KW - Lymphocytes B KW - Germinal centers KW - Immunoglobulins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40534110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.atitle=Deoxyuracils+in+Immunoglobulin+Genes+from+Germinal+Center+B+Cells&rft.au=Gearhart%2C+Patricia+J&rft.aulast=Gearhart&rft.aufirst=Patricia&rft.date=2007-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DNA Damage and Oncogenic Stress: Barriers to Chromosomal Translocations T2 - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AN - 40533022; 4522487 JF - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AU - Nussenzweig, Andre Y1 - 2007/02/06/ PY - 2007 DA - 2007 Feb 06 KW - Translocation KW - Stress KW - Chromosome translocations KW - DNA damage KW - Barriers KW - Chromosomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40533022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.atitle=DNA+Damage+and+Oncogenic+Stress%3A+Barriers+to+Chromosomal+Translocations&rft.au=Nussenzweig%2C+Andre&rft.aulast=Nussenzweig&rft.aufirst=Andre&rft.date=2007-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FcaRIIB1 Regulates Plasma Cell Apoptosis and Differentiation through a c-Abl-dependent Pathway T2 - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AN - 40532193; 4522480 JF - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AU - Tzeng, Shiang-Jong Y1 - 2007/02/06/ PY - 2007 DA - 2007 Feb 06 KW - Plasma cells KW - Differentiation KW - Apoptosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40532193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.atitle=FcaRIIB1+Regulates+Plasma+Cell+Apoptosis+and+Differentiation+through+a+c-Abl-dependent+Pathway&rft.au=Tzeng%2C+Shiang-Jong&rft.aulast=Tzeng&rft.aufirst=Shiang-Jong&rft.date=2007-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An shRNA Achilles heel Screen Reveals the Requirement for IRF4 Expression in Plasma Cells and Multiple Myleoma T2 - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AN - 40529915; 4522473 JF - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AU - Shaffer, Arthur L Y1 - 2007/02/06/ PY - 2007 DA - 2007 Feb 06 KW - Plasma cells KW - Interferon regulatory factor 4 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40529915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.atitle=An+shRNA+Achilles+heel+Screen+Reveals+the+Requirement+for+IRF4+Expression+in+Plasma+Cells+and+Multiple+Myleoma&rft.au=Shaffer%2C+Arthur+L&rft.aulast=Shaffer&rft.aufirst=Arthur&rft.date=2007-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural and Transcriptional Changes that Accompany IgH Gene Rearrangements T2 - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AN - 40529909; 4522421 JF - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AU - Sen, Ranjan Y1 - 2007/02/06/ PY - 2007 DA - 2007 Feb 06 KW - Transcription KW - Immunoglobulins KW - Gene rearrangement KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40529909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.atitle=Structural+and+Transcriptional+Changes+that+Accompany+IgH+Gene+Rearrangements&rft.au=Sen%2C+Ranjan&rft.aulast=Sen&rft.aufirst=Ranjan&rft.date=2007-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Essential Role of IL-21 for Plasma Cell Generation during T Cell- B Cell Collaboration T2 - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AN - 40529717; 4522468 JF - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AU - Ettinger, Rachel C Y1 - 2007/02/06/ PY - 2007 DA - 2007 Feb 06 KW - Lymphocytes B KW - Interleukin 21 KW - Plasma cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40529717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.atitle=Essential+Role+of+IL-21+for+Plasma+Cell+Generation+during+T+Cell-+B+Cell+Collaboration&rft.au=Ettinger%2C+Rachel+C&rft.aulast=Ettinger&rft.aufirst=Rachel&rft.date=2007-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Loss of Function RNA Interference Screen Identifies Genes Involve in Multiple Myeloma Proliferation and Survival T2 - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AN - 40529352; 4522502 JF - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AU - Lamy, Laurence Y1 - 2007/02/06/ PY - 2007 DA - 2007 Feb 06 KW - Survival KW - Multiple myeloma KW - RNA-mediated interference KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40529352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.atitle=A+Loss+of+Function+RNA+Interference+Screen+Identifies+Genes+Involve+in+Multiple+Myeloma+Proliferation+and+Survival&rft.au=Lamy%2C+Laurence&rft.aulast=Lamy&rft.aufirst=Laurence&rft.date=2007-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TLR7 Gene Dosage is Critical for Autoantibody Production and Pathology in Mouse Models of Lupus T2 - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AN - 40528693; 4522507 JF - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AU - Deane, Jonathan A Y1 - 2007/02/06/ PY - 2007 DA - 2007 Feb 06 KW - Pathology KW - Autoantibodies KW - Gene dosage KW - Toll-like receptors KW - TLR7 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40528693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.atitle=TLR7+Gene+Dosage+is+Critical+for+Autoantibody+Production+and+Pathology+in+Mouse+Models+of+Lupus&rft.au=Deane%2C+Jonathan+A&rft.aulast=Deane&rft.aufirst=Jonathan&rft.date=2007-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Loss of Function RNA Interference Screens for Molecular Targets in Lymphoid Malignancies T2 - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AN - 40526435; 4522492 JF - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AU - Staudt, Louis M Y1 - 2007/02/06/ PY - 2007 DA - 2007 Feb 06 KW - Malignancy KW - RNA-mediated interference KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40526435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.atitle=Loss+of+Function+RNA+Interference+Screens+for+Molecular+Targets+in+Lymphoid+Malignancies&rft.au=Staudt%2C+Louis+M&rft.aulast=Staudt&rft.aufirst=Louis&rft.date=2007-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Nanostructure Design Using Protein Building Blocks Enhanced by Conformation ally Constrained Synthetic Residues AN - 20394730; 7728872 AB - Increasing efforts are being invested in the construction of nanostructures with desired shapes and physical and chemical properties. Our strategy involves nanostructure design using naturally occurring protein building blocks. Inspection of the protein structural database (PDB) reveals the richness of the conformations, shapes, and chemistries of proteins and their building blocks. To increase the population of the native fold in the selected building block, we mutate natural residues by engineered, constrained residues that restrict the conformational freedom at the targeted site and have favorable interactions, geometry, and size. Here, as a model system, we construct nanotubes using building blocks from left-handed beta -helices which are commonly occurring repeat protein architectures. We pick two-turn beta -helical segments, duplicate and stack them, and using all-atom molecular dynamics simulations (MD) with explicit solvent probe the structural stability of these nanotubular structures as indicated by then-capacity to retain the initial organization and their conformational dynamics. Comparison of the results for the wild-type and mutated sequences shows that the introduction of the conformationally restricted 1-aminocyclopropanecarboxylic acid (Ac sub(3)c) residue in loop regions greatly enhances the stability of beta -helix nanotubes. The Ac sub(3)c geometrical confinement effect is sequence-specific and position-specific. The achievement of high stability of nanotubular structures originates not only from the reduction of mobility at the mutation site induced by Ac sub(3)c but also from stabilizing association forces between building blocks such as hydrogen bonds and hydrophobic contacts. For the selected synthetic residue, similar size, hydrophobicity, and backbone conformational tendencies are desirable as in the Ac sub(3)c. JF - Biochemistry (Washington) AU - Zheng, J AU - Zanuy, D AU - Haspel, N AU - Tsai, C-J AU - Aleman, C AU - Nussinov, R AD - Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, NCI-FCRDC, Frederick, Maryland 21702, USA Y1 - 2007/02/06/ PY - 2007 DA - 2007 Feb 06 SP - 1205 EP - 1218 VL - 46 IS - 5 SN - 0006-2960, 0006-2960 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Handedness KW - Mobility KW - Hydrogen bonding KW - Solvents KW - nanotubes KW - Hydrophobicity KW - Mutation KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20394730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Nanostructure+Design+Using+Protein+Building+Blocks+Enhanced+by+Conformation+ally+Constrained+Synthetic+Residues&rft.au=Zheng%2C+J%3BZanuy%2C+D%3BHaspel%2C+N%3BTsai%2C+C-J%3BAleman%2C+C%3BNussinov%2C+R&rft.aulast=Zheng&rft.aufirst=J&rft.date=2007-02-06&rft.volume=46&rft.issue=5&rft.spage=1205&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi061674a LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Hydrophobicity; nanotubes; Hydrogen bonding; Mobility; Solvents; Handedness; Databases; Mutation DO - http://dx.doi.org/10.1021/bi061674a ER - TY - JOUR T1 - Down-regulation of DNA polymerase beta accompanies somatic hypermutation in human BL2 cell lines. AN - 68426730; 17127106 AB - Somatic hypermutation (SHM) is a fundamental process in immunoglobulin gene maturation that results in increased affinity of antibodies toward antigens. In one hypothesis explaining SHM in human B cells, the process is initiated by enzymatic deamination of cytosine to uracil in the immunoglobulin gene V-region and this in turn triggers mutation-prone forms of uracil-DNA base excision repair (BER). Yet, an uncertainty with this model is that BER of uracil-DNA in mammalian cells is generally error-free, wherein DNA polymerase beta (pol beta) conducts gap-filling synthesis by insertion of bases according to Watson-Crick rules. To evaluate this inconsistency, we examined pol beta expression in various SHM proficient human BL2 cell line subclones. We report that expression of pol beta in SHM proficient cell lines was strongly down-regulated. In contrast, in other BL2 subclones, we found that SHM was deficient and that pol beta expression was much higher than in the SHM proficient subclones. We also found that overexpression of recombinant human pol beta in a SHM proficient subclone abrogated its capacity for SHM. These results suggest that down-regulation of the normal BER gap-filling DNA polymerase, pol beta, accompanies induced SHM in BL2 cells. This is consistent with the hypothesis that normal error-free BER must be silenced to make way for an error-prone BER process that may be required during somatic hypermutation. JF - DNA repair AU - Poltoratsky, Vladimir AU - Prasad, Rajendra AU - Horton, Julie K AU - Wilson, Samuel H AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, PO Box 12233, MD B2-06, Research Triangle Park, NC 27709, USA. Y1 - 2007/02/04/ PY - 2007 DA - 2007 Feb 04 SP - 244 EP - 253 VL - 6 IS - 2 SN - 1568-7864, 1568-7864 KW - Immunoglobulin Variable Region KW - 0 KW - Oligodeoxyribonucleotides KW - Recombinant Proteins KW - DNA Polymerase beta KW - EC 2.7.7.- KW - Index Medicus KW - Immunoglobulin Variable Region -- genetics KW - DNA Repair KW - Humans KW - Oligodeoxyribonucleotides -- genetics KW - Recombinant Proteins -- genetics KW - Mutagenesis KW - Base Sequence KW - Down-Regulation KW - Recombinant Proteins -- metabolism KW - Adult KW - In Vitro Techniques KW - Substrate Specificity KW - Oligodeoxyribonucleotides -- metabolism KW - Palatine Tonsil -- enzymology KW - Immunohistochemistry KW - Cell Line KW - Male KW - Somatic Hypermutation, Immunoglobulin KW - DNA Polymerase beta -- genetics KW - DNA Polymerase beta -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68426730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+repair&rft.atitle=Down-regulation+of+DNA+polymerase+beta+accompanies+somatic+hypermutation+in+human+BL2+cell+lines.&rft.au=Poltoratsky%2C+Vladimir%3BPrasad%2C+Rajendra%3BHorton%2C+Julie+K%3BWilson%2C+Samuel+H&rft.aulast=Poltoratsky&rft.aufirst=Vladimir&rft.date=2007-02-04&rft.volume=6&rft.issue=2&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=DNA+repair&rft.issn=15687864&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-28 N1 - Date created - 2007-01-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genes Dev. 2000 Jul 1;14(13):1642-50 [10887158] Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1166-71 [10655502] Cell. 2000 Sep 1;102(5):553-63 [11007474] J Exp Med. 2000 Nov 20;192(10):F27-30 [11085756] Science. 2001 Mar 16;291(5511):2156-9 [11251121] Nat Immunol. 2001 Jun;2(6):537-41 [11376341] Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7976-81 [11427727] J Biol Chem. 2001 Sep 14;276(37):34659-63 [11457865] Chromosoma. 2001 Nov;110(6):402-10 [11734998] J Biol Chem. 2002 Apr 12;277(15):13184-91 [11821417] Proc Natl Acad Sci U S A. 2002 May 14;99(10):6860-5 [11983862] Nature. 2002 Jul 4;418(6893):99-103 [12097915] Nat Immunol. 2002 Sep;3(9):815-21 [12145648] Curr Biol. 2002 Oct 15;12(20):1748-55 [12401169] Nature. 2002 Oct 31;419(6910):944-7 [12410315] DNA Repair (Amst). 2003 Jan 2;2(1):27-48 [12509266] DNA Repair (Amst). 2003 May 13;2(5):609-22 [12713817] Cold Spring Harb Symp Quant Biol. 2000;65:143-55 [12760029] J Biol Chem. 2003 Jul 11;278(28):25947-51 [12734201] Nat Immunol. 2003 Oct;4(10):1023-8 [12958596] Cancer Res. 2004 Mar 15;64(6):1924-31 [15026325] Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4262-7 [14999097] Nature. 1970 Dec 12;228(5276):1045-7 [5483159] Nucleic Acids Res. 1977 Aug;4(8):2917-29 [909796] Cell Differ. 1978 Oct;7(5):237-48 [699053] Nature. 1993 Apr 22;362(6422):709-15 [8469282] J Biol Chem. 1995 Jan 13;270(2):949-57 [7822335] J Biol Chem. 1995 Jul 7;270(27):16402-8 [7608211] Science. 1995 Aug 4;269(5224):699-702 [7624801] Nature. 1996 Jan 11;379(6561):183-6 [8538772] J Biol Chem. 1996 Jul 26;271(30):17811-5 [8663612] Immunity. 1997 Jan;6(1):35-46 [9052835] J Biol Chem. 1998 Jan 9;273(2):898-902 [9422747] Mutat Res. 1999 Mar;436(2):157-78 [10095138] J Biol Chem. 2005 Sep 9;280(36):31641-7 [16002405] DNA Repair (Amst). 2005 Sep 28;4(10):1182-8 [15950550] Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13986-91 [16172387] EMBO J. 2005 Nov 2;24(21):3757-69 [16222339] Curr Opin Immunol. 2006 Apr;18(2):164-74 [16464563] J Immunol. 2000 Feb 1;164(3):1306-13 [10640744] Nature. 2000 Aug 31;406(6799):1015-9 [10984059] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison AN - 19988837; 7422936 AB - Background Although the use of magnetic resonance imaging (MRI) for the diagnosis of acute stroke is increasing, this method has not proved more effective than computed tomography (CT) in the emergency setting. We aimed to prospecnvely compare CT and MRI for emergency diagnosis of acute stroke. Methods We did a single-centre, prospective, blind comparison of non-contrast CT and MRI (with diffusion-weighted and susceptibility weighted images) in a consecutive series of patients referred for emergency assessment of suspected acute stroke. Scans were independently interpreted by four experts, who were unaware of clinical information, MRI-CT pairings, and follow-up imaging. Results 356 patients, 217 of whom had a final clinical diagnosis of acute stroke, were assessed. MRI detected acute stroke (ischaemic or haemorrhagic), acute ischaemic stroke, and chronic haemorrhage more frequently than did CT (p<0.0001, for all comparisons). MRI was similar to CT for the detection of acute intracranial haemorrhage. MRI detected acute ischaemic stroke in 164 of 356 patients (46%; 95% CI 41-51%), compared with CT in 35 of 356 patients (10%; 7-14%). In the subset of patients scanned within 3 h of symptom onset, MRI detected acute ischaemic stroke in 41 of 90 patients (46%; 35-56%); CT in 6 of 90 (7%; 3-14%). Relative to the final clinical diagnosis, MRI had a sensitivity of 83% (181 of 217; 78-88%) and CT of 26% (56 of 217; 20-32%) for the diagnosis of any acute stroke. Interpretation MRI is better than CT for detection of acute ischaemia, and can detect acute and chronic haemorrhage; therefore it should be the preferred test for accurate diagnosis of patients with suspected acute stroke. Because our patient sample encompassed the range of disease that is likely to be encountered in emergency cases of suspected stroke, our results are directly applicable to clinical practice. JF - Lancet AU - Chalela, JA AU - Kidwell, C S AU - Nentwich, L M AU - Luby, M AU - Butman, JA AU - Demchuk, A M AU - Hill, MD AU - Patronas, N AU - Latour, L AU - Warach, S AD - Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Rm B1D733, MSC 1063 Bethesda, MD 20892, USA, warachs@ninds.nih.gov Y1 - 2007/02/02/ PY - 2007 DA - 2007 Feb 02 SP - 293 EP - 298 VL - 369 IS - 9558 SN - 0099-5355, 0099-5355 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Stroke KW - Magnetic resonance imaging KW - Computed tomography KW - Ischemia KW - Hemorrhage KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19988837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Magnetic+resonance+imaging+and+computed+tomography+in+emergency+assessment+of+patients+with+suspected+acute+stroke%3A+a+prospective+comparison&rft.au=Chalela%2C+JA%3BKidwell%2C+C+S%3BNentwich%2C+L+M%3BLuby%2C+M%3BButman%2C+JA%3BDemchuk%2C+A+M%3BHill%2C+MD%3BPatronas%2C+N%3BLatour%2C+L%3BWarach%2C+S&rft.aulast=Chalela&rft.aufirst=JA&rft.date=2007-02-02&rft.volume=369&rft.issue=9558&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Lancet&rft.issn=00995355&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Computed tomography; Magnetic resonance imaging; Stroke; Ischemia; Hemorrhage ER - TY - JOUR T1 - Energy Policy Act of 2005 AN - 746200303; 11366631 AB - This article provides a comprehensive review and describes the impact of the bill on distributed generation, the electricity market, the national electrical grid, and the future of how electricity will be delivered in the United States. The energy policy act of 2005 removes the requirement that utilities purchase power under the condition that the qualifying facility has access to alternative markets. A single IEEE 1547 standard could be applied to any distributed resource interconnection. JF - IEEE Industry Applications Magazine AU - Malmedal, K AU - Kroposki, B AU - Sen, P K AD - NEI Electr. Power Eng., Arvada, CO Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 14 EP - 20 PB - Institute of Electrical and Electronics Engineers, Inc., 3 Park Avenue, 17th Fl New York NY 10016-5997 USA VL - 13 IS - 1 SN - 1077-2618, 1077-2618 KW - Sustainability Science Abstracts KW - USA KW - energy policy KW - Reviews KW - Utilities KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746200303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Industry+Applications+Magazine&rft.atitle=Energy+Policy+Act+of+2005&rft.au=Malmedal%2C+K%3BKroposki%2C+B%3BSen%2C+P+K&rft.aulast=Malmedal&rft.aufirst=K&rft.date=2007-02-01&rft.volume=13&rft.issue=1&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=IEEE+Industry+Applications+Magazine&rft.issn=10772618&rft_id=info:doi/10.1109%2FMIA.2007.265799 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - energy policy; Reviews; Utilities; USA DO - http://dx.doi.org/10.1109/MIA.2007.265799 ER - TY - JOUR T1 - Invited comment: "Identification of a sensitive period for developmental programming that increases risk for uterine leiomyoma in Eker rats". AN - 70764615; 17636221 JF - Reproductive sciences (Thousand Oaks, Calif.) AU - Segars, James H AD - Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. segarsj@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 99 EP - 100 VL - 14 IS - 2 KW - Estrogens, Non-Steroidal KW - 0 KW - Tumor Suppressor Proteins KW - tuberous sclerosis complex 2 protein KW - 4JG2LF96VF KW - Diethylstilbestrol KW - 731DCA35BT KW - Index Medicus KW - Rats KW - Animals KW - Rats, Mutant Strains KW - Humans KW - Tumor Suppressor Proteins -- genetics KW - Mutation KW - Gene Expression Regulation, Developmental -- drug effects KW - Female KW - Uterine Neoplasms -- chemically induced KW - Diethylstilbestrol -- toxicity KW - Estrogens, Non-Steroidal -- toxicity KW - Leiomyoma -- chemically induced KW - Uterus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70764615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Improved+Antibacterial+Host+Defense+and+Altered+Peripheral+Granulocyte+Homeostasis+in+Mice+Lacking+the+Adhesion+Class+G+Protein+Receptor+CD97&rft.au=Wang%2C+Tao%3BTian%2C+Linhua%3BHaino%2C+Makoto%3BGao%2C+Ji-Liang%3BLake%2C+Ross%3BWard%2C+Yvona%3BWang%2C+Hongshan%3BSiebenlist%2C+Ulrich%3BMurphy%2C+Philip+M%3BKelly%2C+Kathleen&rft.aulast=Wang&rft.aufirst=Tao&rft.date=2007-03-01&rft.volume=75&rft.issue=3&rft.spage=1144&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-26 N1 - Date created - 2007-07-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Reprod Sci. 2007 Feb;14(2):121-36 [17636224] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dosimetry in myeloablative (90)Y-labeled ibritumomab tiuxetan therapy: possibility of increasing administered activity on the base of biological effective dose evaluation. Preliminary results. AN - 70707894; 17627419 AB - In our multicentric ongoing phase I activity escalation study, (90)Y-labeled ibritumomab tiuxetan (Ze-valin was administered in activity per kilo twice- and three times the maximum tolerable dose of 15 MBq/kg suggested for nonmyeloablative treatments by the U.S. registration study. The radioinduced myelodepression was overcome by stem cell autografting. The dosimetric aim was to correlate possible extramedullary toxicities to the organ-absorbed doses or to the biologic effective dose (BED). This is a conceptually more suitable parameter, as it takes into account not only the absorbed dose, but also the influence of the dose rate and of the tissue repair mechanism. Pretreatment planar dosimetry was performed on 16 patients with a median 200 MBq of (111)In-Zevalin. Conjugate view technique, background, attenuation, and partial scatter correction were adopted. Blood samples and a planar whole body scintigram were collected at least at 0.5, 48, 96, and 120 hours. Individual organ mass correction was based on a computed tomography scan. Internal dose calculation was performed by the OLINDA/EXM software. One (1) week after dosimetry, 12 patients were treated with 30 MBq/kg and 4 patients with 45 MBq/kg of (90)Y-Zevalin. The absorbed dose per unit activity (Gy/GBq) were (median and range of 16 dosimetric studies): heart wall 3.8 [0.5, 9.7]; kidneys 4.9 [2.8, 10.5]; liver 5.5 [3.9, 8.9]; lungs 2.8 [0.4, 6.8]; red marrow 1.1 [0.8, 2.1]; spleen 6.3 [1.5, 10.9]; and testes 4.6 [3.0, 16.7]. The absorbed dose (Gy) for the 4 patients administered with 45 MBq/kg were (median and range): heart wall 17.6 [9.4, 25.1]; kidneys 16.3 [7.9, 20.3]; liver 20.9 [15.4, 24.3]; lungs 7.7 [5.6, 11.4]; red marrow 3.0 [2.4, 3.3]; spleen 28.4 [18.9, 30.8]; and testes 16.5 [12.2, 17.3]. No extramedullary toxicity was observed. The administration of 45 MBq/kg of (90)Y ibritumomab tiuxetan to 4 patients with stem cell autografting was free from extramedullary toxicity. This is in agreement with both organ doses and BEDs below the corresponding toxicity thresholds. For these clinical and dosimetric reasons, a further increase in injectable activity could have been conceivable. If the more appropriate BED parameter were chosen for toxicity limit calculations, a wider margin of increase would have been possible. Our theoretical investigation demonstrates that, in this particular case of (90)Y Zevalin therapy, the uncertainty about radiobiological parameters was not a limiting factor for a BED-based calculation of the maximum injectable activity. JF - Cancer biotherapy & radiopharmaceuticals AU - Chiesa, Carlo AU - Botta, Francesca AU - Di Betta, Erika AU - Coliva, Angela AU - Maccauro, Marco AU - Aliberti, Gianluca AU - Bavusi, Sergio AU - Devizzi, Liliana AU - Guidetti, Anna AU - Seregni, Ettore AU - Gianni, Alessandro Massimo AU - Bombardieri, Emilio AD - Nuclear Medicine, National Cancer Institute, Milan, Italy. carlo.chiesa@istitutotumori.mi.it Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 113 EP - 120 VL - 22 IS - 1 SN - 1084-9785, 1084-9785 KW - Antibodies, Monoclonal KW - 0 KW - Myeloablative Agonists KW - Yttrium Radioisotopes KW - ibritumomab tiuxetan KW - 4Q52C550XK KW - Index Medicus KW - Radioimmunotherapy KW - Humans KW - Dose-Response Relationship, Radiation KW - Myeloablative Agonists -- immunology KW - Lymphoma, Non-Hodgkin -- therapy KW - Myeloablative Agonists -- therapeutic use KW - Antibodies, Monoclonal -- adverse effects KW - Myeloablative Agonists -- adverse effects KW - Myeloablative Agonists -- administration & dosage KW - Lymphoma, Non-Hodgkin -- immunology KW - Lymphoma, Non-Hodgkin -- pathology KW - Antibodies, Monoclonal -- administration & dosage KW - Antibodies, Monoclonal -- therapeutic use KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70707894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+biotherapy+%26+radiopharmaceuticals&rft.atitle=Dosimetry+in+myeloablative+%2890%29Y-labeled+ibritumomab+tiuxetan+therapy%3A+possibility+of+increasing+administered+activity+on+the+base+of+biological+effective+dose+evaluation.+Preliminary+results.&rft.au=Chiesa%2C+Carlo%3BBotta%2C+Francesca%3BDi+Betta%2C+Erika%3BColiva%2C+Angela%3BMaccauro%2C+Marco%3BAliberti%2C+Gianluca%3BBavusi%2C+Sergio%3BDevizzi%2C+Liliana%3BGuidetti%2C+Anna%3BSeregni%2C+Ettore%3BGianni%2C+Alessandro+Massimo%3BBombardieri%2C+Emilio&rft.aulast=Chiesa&rft.aufirst=Carlo&rft.date=2007-02-01&rft.volume=22&rft.issue=1&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Cancer+biotherapy+%26+radiopharmaceuticals&rft.issn=10849785&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-20 N1 - Date created - 2007-07-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The role of the mitochondria in mediating cytotoxicity of anti-cancer therapies. AN - 70568567; 17294132 AB - Optimal cytotoxic anticancer therapy, at the cellular level, requires effective and selective induction of cell death to achieve a net reduction of biomass of malignant tissues. Standard cytotoxic chemotherapeutics have been developed based on the observations that mitotically active cancer cells are more susceptible than quiescent normal cells to chromosomal, microtubular or metabolic poisons. More recent development of molecularly targeted drugs for cancer focuses on exploiting biological differentials between normal and transformed cells for selective eradication of cancers. The common thread of "standard" and "novel" cytotoxic drugs is their ability to activate the apoptosis-inducing machinery mediated by mitochondria, also known as the intrinsic death signaling cascade. The aim of this article is to provide an overview of the role of the mitochondria, an energy-generating organelle essential for life, in mediating death when properly activated by cytotoxic stresses. JF - Journal of bioenergetics and biomembranes AU - Nguyen, Dao M AU - Hussain, Mustafa AD - Section of Thoracic Oncology, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Room 4W-4-3940, 10 Center Drive, Bethesda, MD 29892, USA. dao_nguyen@nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 13 EP - 21 VL - 39 IS - 1 SN - 0145-479X, 0145-479X KW - Antineoplastic Agents KW - 0 KW - TNF-Related Apoptosis-Inducing Ligand KW - Index Medicus KW - Animals KW - Humans KW - TNF-Related Apoptosis-Inducing Ligand -- metabolism KW - Cell Death -- drug effects KW - Neoplasms -- drug therapy KW - Mitochondria -- physiology KW - Apoptosis -- physiology KW - Signal Transduction -- drug effects KW - Mitochondria -- drug effects KW - Apoptosis -- drug effects KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70568567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bioenergetics+and+biomembranes&rft.atitle=The+role+of+the+mitochondria+in+mediating+cytotoxicity+of+anti-cancer+therapies.&rft.au=Nguyen%2C+Dao+M%3BHussain%2C+Mustafa&rft.aulast=Nguyen&rft.aufirst=Dao&rft.date=2007-02-01&rft.volume=39&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Journal+of+bioenergetics+and+biomembranes&rft.issn=0145479X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-01 N1 - Date created - 2007-06-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evidence for an intensity-dependent interaction of NAT2 acetylation genotype and cigarette smoking in the Spanish Bladder Cancer Study. AN - 70521342; 17510079 AB - The N-acetyltransferase 2 (NAT2) enzyme detoxifies aromatic amines, an important class of carcinogens in tobacco smoke. Slow acetylation phenotype individuals have reduced detoxification capacity compared with those with a rapid/intermediate phenotype. Analysis of the Spanish Bladder Cancer Study found an odds ratio (OR) for slow acetylators relative to rapid/intermediate acetylators of 0.9 in never-smokers and 1.6 in ever-smokers, a 1.8-fold enhancement in smokers. Evidence indicates that acetylation is an exposure-dependent process, and thus the magnitude of the interaction may also depend on exposure level. We extend a comprehensive three-parameter linear-exponential model for the excess odds ratio (EOR) for smoking to include effects of NAT2 status, and reanalyse smoking and NAT2 status for the bladder cancer data. We show that variations in smoking risk with NAT2 status result from interactions with smoking intensity (cigarettes per day) and not total pack-years of exposure. In addition, the relative increase in smoking risk in NAT2 slo acetylators increases with smoking intensity. Analyses reveal an enhanced effect for smoking intensity and bladder cancer in NAT2 slow acetylators which increases with intensity. JF - International journal of epidemiology AU - Lubin, Jay H AU - Kogevinas, Manolis AU - Silverman, Debra AU - Malats, Núria AU - Garcia-Closas, Montserrat AU - Tardón, Adonina AU - Hein, David W AU - Garcia-Closas, Reina AU - Serra, Consol AU - Dosemeci, Mustafa AU - Carrato, Alfredo AU - Rothman, Nathaniel AD - Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., Rockville, MD 20852, USA. lubinj@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 236 EP - 241 VL - 36 IS - 1 SN - 0300-5771, 0300-5771 KW - Tobacco Smoke Pollution KW - 0 KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - NAT2 protein, human KW - Index Medicus KW - Humans KW - Linear Models KW - Aged KW - Risk Assessment -- methods KW - Genotype KW - Phenotype KW - Acetylation KW - Aged, 80 and over KW - Adult KW - Tobacco Smoke Pollution -- adverse effects KW - Middle Aged KW - Spain -- epidemiology KW - Tobacco -- adverse effects KW - Urinary Bladder Neoplasms -- epidemiology KW - Urinary Bladder Neoplasms -- genetics KW - Smoking -- metabolism KW - Urinary Bladder Neoplasms -- enzymology KW - Arylamine N-Acetyltransferase -- metabolism KW - Smoking -- epidemiology KW - Arylamine N-Acetyltransferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70521342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+epidemiology&rft.atitle=Evidence+for+an+intensity-dependent+interaction+of+NAT2+acetylation+genotype+and+cigarette+smoking+in+the+Spanish+Bladder+Cancer+Study.&rft.au=Lubin%2C+Jay+H%3BKogevinas%2C+Manolis%3BSilverman%2C+Debra%3BMalats%2C+N%C3%BAria%3BGarcia-Closas%2C+Montserrat%3BTard%C3%B3n%2C+Adonina%3BHein%2C+David+W%3BGarcia-Closas%2C+Reina%3BSerra%2C+Consol%3BDosemeci%2C+Mustafa%3BCarrato%2C+Alfredo%3BRothman%2C+Nathaniel&rft.aulast=Lubin&rft.aufirst=Jay&rft.date=2007-02-01&rft.volume=36&rft.issue=1&rft.spage=236&rft.isbn=&rft.btitle=&rft.title=International+journal+of+epidemiology&rft.issn=03005771&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-30 N1 - Date created - 2007-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Commentary: From phenotype, to genotype, to gene-environment interaction and risk for complex diseases. AN - 70520279; 17510072 JF - International journal of epidemiology AU - Olden, Kenneth AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences/NIH, Research Triangle Park, NC 27705, USA. olden@niehs.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 18 EP - 20 VL - 36 IS - 1 SN - 0300-5771, 0300-5771 KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - NAT2 protein, human KW - Index Medicus KW - Phenotype KW - Genotype KW - Genetic Predisposition to Disease -- genetics KW - Polymorphism, Genetic -- genetics KW - Humans KW - Environmental Exposure -- adverse effects KW - Urinary Bladder Neoplasms -- epidemiology KW - Urinary Bladder Neoplasms -- genetics KW - Urinary Bladder Neoplasms -- enzymology KW - Arylamine N-Acetyltransferase -- toxicity KW - Arylamine N-Acetyltransferase -- analysis KW - Arylamine N-Acetyltransferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70520279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+epidemiology&rft.atitle=Commentary%3A+From+phenotype%2C+to+genotype%2C+to+gene-environment+interaction+and+risk+for+complex+diseases.&rft.au=Olden%2C+Kenneth&rft.aulast=Olden&rft.aufirst=Kenneth&rft.date=2007-02-01&rft.volume=36&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=International+journal+of+epidemiology&rft.issn=03005771&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-30 N1 - Date created - 2007-05-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Int J Epidemiol. 2007 Feb;36(1):11-8 [17353184] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Commentary: Reflections on G. M. Lower and colleagues' 1979 study associating slow acetylator phenotype with urinary bladder cancer: meta-analysis, historical refinements of the hypothesis, and lessons learned. AN - 70514563; 17510073 JF - International journal of epidemiology AU - Rothman, Nathaniel AU - Garcia-Closas, Montserrat AU - Hein, David W AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health/DHHS, Bethesda, MD 20892, USA. rothmann@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 23 EP - 28 VL - 36 IS - 1 SN - 0300-5771, 0300-5771 KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - NAT2 protein, human KW - Index Medicus KW - Phenotype KW - Acetylation KW - Genetic Predisposition to Disease -- genetics KW - Humans KW - Environmental Exposure -- adverse effects KW - Urinary Bladder Neoplasms -- epidemiology KW - Urinary Bladder Neoplasms -- genetics KW - Urinary Bladder Neoplasms -- enzymology KW - Arylamine N-Acetyltransferase -- metabolism KW - Arylamine N-Acetyltransferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70514563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+epidemiology&rft.atitle=Commentary%3A+Reflections+on+G.+M.+Lower+and+colleagues%27+1979+study+associating+slow+acetylator+phenotype+with+urinary+bladder+cancer%3A+meta-analysis%2C+historical+refinements+of+the+hypothesis%2C+and+lessons+learned.&rft.au=Rothman%2C+Nathaniel%3BGarcia-Closas%2C+Montserrat%3BHein%2C+David+W&rft.aulast=Rothman&rft.aufirst=Nathaniel&rft.date=2007-02-01&rft.volume=36&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=International+journal+of+epidemiology&rft.issn=03005771&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-30 N1 - Date created - 2007-05-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Int J Epidemiol. 2007 Feb;36(1):11-8 [17353184] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Image-guided convection-enhanced delivery of gemcitabine to the brainstem. AN - 70353517; 17410722 AB - To determine if the potent antiglioma chemotherapeutic agent gemcitabine could be delivered to the brainstem safely at therapeutic doses while monitoring its distribution using a surrogate magnetic resonance (MR) imaging tracer, the authors used convection-enhanced delivery to perfuse the primate brainstem with gemcitabine and Gd-diethylenetriamine pentaacetic acid (DTPA). Six primates underwent convective brainstem perfusion with gemcitabine (0.4 mg/ml; two animals), Gd-DTPA (5 mM; two animals), or a coinfusion of gemcitabine (0.4 mg/ml) and Gd-DTPA (5 mM; two animals), and were killed 28 days afterward. These primates were observed over time clinically (six animals), and with MR imaging (five animals), quantitative autoradiography (one animal), and histological analysis (all animals). In an additional primate, 3H-gemcitabine and Gd-DTPA were coinfused and the animal was killed immediately afterward. In the primates there was no histological evidence of infusate-related tissue toxicity. Magnetic resonance images obtained during infusate delivery demonstrated that the anatomical region infused with Gd-DTPA was clearly distinguishable from surrounding noninfused tissue. Quantitative autoradiography confirmed that Gd-DTPA tracked the distribution of 3H-gemcitabine and closely approximated its volume of distribution (mean volume of distribution difference 13.5%). Conclusions. Gemcitabine can be delivered safely and effectively to the primate brainstem at therapeutic concentrations and at volumes that are higher than those considered clinically relevant. Moreover, MR imaging can be used to track the distribution of gemcitabine by adding Gd-DTPA to the infusate. This delivery paradigm should allow for direct therapeutic application of gemcitabine to brainstem gliomas while monitoring its distribution to ensure effective tumor coverage and to maximize safety. JF - Journal of neurosurgery AU - Murad, Gregory J A AU - Walbridge, Stuart AU - Morrison, Paul F AU - Szerlip, Nicholas AU - Butman, John A AU - Oldfield, Edward H AU - Lonser, Russell R AD - Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1414, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 351 EP - 356 VL - 106 IS - 2 SN - 0022-3085, 0022-3085 KW - Antimetabolites, Antineoplastic KW - 0 KW - Contrast Media KW - Deoxycytidine KW - 0W860991D6 KW - gemcitabine KW - B76N6SBZ8R KW - Gadolinium DTPA KW - K2I13DR72L KW - Abridged Index Medicus KW - Index Medicus KW - Magnetic Resonance Imaging KW - Animals KW - Macaca mulatta KW - Convection KW - Antimetabolites, Antineoplastic -- administration & dosage KW - Brain Stem -- metabolism KW - Infusions, Intralesional -- methods KW - Deoxycytidine -- pharmacokinetics KW - Deoxycytidine -- analogs & derivatives KW - Deoxycytidine -- administration & dosage KW - Antimetabolites, Antineoplastic -- pharmacokinetics KW - Therapy, Computer-Assisted UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70353517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurosurgery&rft.atitle=Image-guided+convection-enhanced+delivery+of+gemcitabine+to+the+brainstem.&rft.au=Murad%2C+Gregory+J+A%3BWalbridge%2C+Stuart%3BMorrison%2C+Paul+F%3BSzerlip%2C+Nicholas%3BButman%2C+John+A%3BOldfield%2C+Edward+H%3BLonser%2C+Russell+R&rft.aulast=Murad&rft.aufirst=Gregory+J&rft.date=2007-02-01&rft.volume=106&rft.issue=2&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurosurgery&rft.issn=00223085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-15 N1 - Date created - 2007-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dust weight and asthma prevalence in the National Survey of Lead and Allergens in Housing (NSLAH). AN - 70304909; 17384767 AB - Settled dust has been used in studies to assess exposures to allergens and other biologically active components, but it has not been considered in the aggregate in relation to respiratory health outcomes in the general population. We addressed whether total house dust weight, an index of total dust exposure, was associated with respiratory health outcomes in the National Survey of Lead and Allergens in Housing (1998-1999) (NSLAH). NSLAH was a cross-sectional survey designed to represent permanently occupied housing units in the United States. In each household, a questionnaire was administered and settled dust was vacuumed from five locations. Linear regression models were used to identify predictors of dust weight; logistic regression models were used to examine the relationship between dust weight and asthma and wheeze. Dust weight samples were available for 829 households, and survey information was available for 2,456 participants (children and adults). Lower income, older homes, household pets, having a smoker in the house, and less frequent cleaning predicted higher dust weight levels in U.S. households. Higher levels of dust weight were associated with greater odds of current asthma and wheeze. The strongest associations were seen for wheeze [adjusted odds ratio (OR) = 1.99; 95% confidence interval (CI), 1.21-3.28 for bedroom bed dust; OR = 2.81; 95% CI, 1.52-5.21 for upholstery dust). These associations persisted when adjusting for allergen and endotoxin exposures. Dust weight, an index of total dust exposure in the home, may contribute to respiratory outcomes independently of the exposure to specific components. JF - Environmental health perspectives AU - Elliott, Leslie AU - Arbes, Samuel J AU - Harvey, Eric S AU - Lee, Robert C AU - Salo, Päivi M AU - Cohn, Richard D AU - London, Stephanie J AU - Zeldin, Darryl C AD - Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 215 EP - 220 VL - 115 IS - 2 SN - 0091-6765, 0091-6765 KW - Allergens KW - 0 KW - Dust KW - Lead KW - 2P299V784P KW - Index Medicus KW - United States KW - Environmental Monitoring KW - Regression Analysis KW - Cross-Sectional Studies KW - Particle Size KW - Humans KW - Health Surveys KW - Environmental Exposure KW - Epidemiological Monitoring KW - Lead -- analysis KW - Asthma -- epidemiology KW - Air Pollution, Indoor -- analysis KW - Housing KW - Dust -- analysis KW - Allergens -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70304909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Dust+weight+and+asthma+prevalence+in+the+National+Survey+of+Lead+and+Allergens+in+Housing+%28NSLAH%29.&rft.au=Elliott%2C+Leslie%3BArbes%2C+Samuel+J%3BHarvey%2C+Eric+S%3BLee%2C+Robert+C%3BSalo%2C+P%C3%A4ivi+M%3BCohn%2C+Richard+D%3BLondon%2C+Stephanie+J%3BZeldin%2C+Darryl+C&rft.aulast=Elliott&rft.aufirst=Leslie&rft.date=2007-02-01&rft.volume=115&rft.issue=2&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-12 N1 - Date created - 2007-03-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Respir Crit Care Med. 2005 Dec 1;172(11):1371-7 [16141442] Environ Health Perspect. 2005 Oct;113(10):1430-6 [16203259] Thorax. 2000 May;55(5):424-31 [10770825] Environ Health Perspect. 2000 Aug;108 Suppl 4:705-12 [10931789] Lancet. 2000 Oct 21;356(9239):1392-7 [11052581] Pediatrics. 2001 Aug;108(2):E33 [11483843] Environ Health Perspect. 2002 May;110(5):527-32 [12003758] Rev Environ Contam Toxicol. 2002;175:1-46 [12206053] Environ Health Perspect. 2002 Oct;110(10):A599-606 [12361941] Environ Health Perspect. 2003 Jul;111(9):1265-72 [12842784] Occup Environ Med. 2003 Sep;60(9):E5 [12937201] Environ Health Perspect. 2004 Apr;112(5):571-4 [15064163] J Expo Anal Environ Epidemiol. 2004;14 Suppl 1:S34-40 [15118743] Environ Health Perspect. 2004 May;112(6):760-5 [15121522] J Expo Anal Environ Epidemiol. 2004 Sep;14(5):397-403 [15361899] Environ Health Perspect. 2004 Oct;112(14):1393-7 [15471731] J Allergy Clin Immunol. 2004 Oct;114(4):858-62 [15480327] Panminerva Med. 2004 Jun;46(2):97-110 [15507879] Int Arch Allergy Appl Immunol. 1966;30(4):368-81 [5927733] Ann Allergy. 1967 Oct;25(10):598-9 [6055710] Ann Allergy. 1969 Mar;27(3):93-9 [5773134] Can Med Assoc J. 1970 Aug 1;103(3):300-1 [4915743] JAMA. 1970 Sep 7;213(10):1687 [5468718] Ann Allergy. 1970 Nov;28(11):543-7 [5521185] Am J Public Health. 1989 Mar;79(3):340-9 [2916724] N Engl J Med. 1990 Aug 23;323(8):502-7 [2377175] Lancet. 1995 Jan 21;345(8943):176-8 [7741860] Clin Exp Allergy. 1995 Feb;25(2):114-8 [7750002] J Allergy Clin Immunol. 1995 Oct;96(4):441-8 [7560653] Rev Environ Contam Toxicol. 1995;143:59-78 [7501867] Int J Epidemiol. 1996 Jun;25(3):609-16 [8671563] Clin Exp Allergy. 1998 May;28(5):537-44 [9645589] Allergy. 1998 Nov;53(11):1060-5 [9860238] Thorax. 1999 Mar;54(3):268-72 [10325905] J Indian Med Assoc. 1958 Apr 1;30(7):216-9 [13549740] J Indian Med Assoc. 1965 Jun 1;44:607-9 [14343895] Allerg Asthma (Leipz). 1964;10:329-34 [14307280] Eur Respir J. 2005 Feb;25(2):303-8 [15684295] Indoor Air. 1999 Dec;9(4):219-25 [10649856] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inferring past pesticide exposures: a matrix of individual active ingredients in home and garden pesticides used in past decades. AN - 70302546; 17384773 AB - In retrospective studies of the health effects of home and garden pesticides, self-reported information typically forms the basis for exposure assessment. Study participants generally find it easier to remember the types of pests treated than the specific pesticides used. However, if the goal of the study is to assess disease risk from specific chemicals, the investigator must be able to link the pest type treated with specific chemicals or products. Our goal was to develop a "pesticide-exposure matrix" that would list active ingredients on the market for treating different types of pests in past years, and provide an estimate of the probability that each active ingredient was used. We used several different methods for deriving the active ingredient lists and estimating the probabilities. These methods are described in this article, along with a sample calculation and data sources for each. The pesticide-exposure matrix lists active ingredients and their probabilities of use for 96 distinct scenarios defined by year (1976, 1980, 1990, 2000), applicator type (consumer, professional), and pest type (12 categories). Calculations and data sources for all 96 scenarios are provided online. Although we are confident that the active ingredient lists are reasonably accurate for most scenarios, we acknowledge possible sources of error in the probability estimates. Despite these limitations, the pesticide-exposure matrix should provide valuable information to researchers interested in the chronic health effects of residential pesticide exposure. JF - Environmental health perspectives AU - Colt, Joanne S AU - Cyr, Mancer J AU - Zahm, Shelia H AU - Tobias, Geoffrey S AU - Hartge, Patricia AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA. coltj@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 248 EP - 254 VL - 115 IS - 2 SN - 0091-6765, 0091-6765 KW - Pesticides KW - 0 KW - Index Medicus KW - Gardening KW - Probability KW - Pest Control KW - Humans KW - Retrospective Studies KW - Risk Assessment -- methods KW - Pesticides -- chemistry KW - Pesticides -- analysis KW - Pesticides -- classification KW - Environmental Exposure -- analysis KW - Environmental Exposure -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70302546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Inferring+past+pesticide+exposures%3A+a+matrix+of+individual+active+ingredients+in+home+and+garden+pesticides+used+in+past+decades.&rft.au=Colt%2C+Joanne+S%3BCyr%2C+Mancer+J%3BZahm%2C+Shelia+H%3BTobias%2C+Geoffrey+S%3BHartge%2C+Patricia&rft.aulast=Colt&rft.aufirst=Joanne&rft.date=2007-02-01&rft.volume=115&rft.issue=2&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-12 N1 - Date created - 2007-03-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Epidemiology. 2001 Jan;12(1):20-7 [11138814] J Expo Anal Environ Epidemiol. 2002 Sep;12(5):373-80 [12198585] Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):934-7 [15824166] Environ Health Perspect. 1997 Nov;105(11):1214-20 [9370522] J Expo Anal Environ Epidemiol. 1997 Apr-Jun;7(2):217-34 [9185013] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hepatic transcript levels for genes coding for enzymes associated with xenobiotic metabolism are altered with age. AN - 70278203; 17366318 AB - Metabolism studies are crucial for data interpretation from rodent toxicity and carcinogenicity studies. Metabolism studies are usually conducted in 6 to 8 week old rodents. Long-term studies often continue beyond 100 weeks of age. The potential for age-related changes in transcript levels of genes encoding for enzymes associated with metabolism was evaluated in the liver of male F344/N rats at 32, 58, and 84 weeks of age. Differential expression was found between the young and old rats for genes whose products are involved in both phase I and phase II metabolic pathways. Thirteen cytochrome P450 genes from CYP families 1-3 showed alterations in expression in the older rats. A marked age-related decrease in expression was found for 4 members of the Cyp3a family that are critical for drug metabolism in the rat. Immunohistochemical results confirmed a significant decrease in Cyp3a2 and Cyp2c11 protein levels with age. This indicates that the metabolic capacity of male rats changes throughout a long-term study. Conducting multiple hepatic microarray analyses during the conduct of a long-term study can provide a global view of potential metabolic changes that might occur. Alterations that are considered crucial to the interpretation of long-term study results could then be confirmed by subsequent metabolic studies. JF - Toxicologic pathology AU - Mori, Kazuhiko AU - Blackshear, Pamela E AU - Lobenhofer, Edward K AU - Parker, Joel S AU - Orzech, Denise P AU - Roycroft, Joseph H AU - Walker, Kimwa L AU - Johnson, Kennita A AU - Marsh, Tiwanda A AU - Irwin, Richard D AU - Boorman, Gary A AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27701, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 242 EP - 251 VL - 35 IS - 2 SN - 0192-6233, 0192-6233 KW - Membrane Proteins KW - 0 KW - Xenobiotics KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP2C11 protein, rat KW - Cyp3a2 protein, rat KW - Cytochrome P-450 CYP3A KW - Cytochrome P450 Family 2 KW - Steroid 16-alpha-Hydroxylase KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Age Factors KW - Gene Expression Regulation, Enzymologic KW - Reproducibility of Results KW - Oligonucleotide Array Sequence Analysis KW - Toxicity Tests KW - Male KW - Transcription, Genetic -- physiology KW - Aging -- metabolism KW - Liver -- enzymology KW - Aryl Hydrocarbon Hydroxylases -- metabolism KW - Steroid 16-alpha-Hydroxylase -- genetics KW - Steroid 16-alpha-Hydroxylase -- metabolism KW - Xenobiotics -- metabolism KW - Membrane Proteins -- metabolism KW - Membrane Proteins -- genetics KW - Aryl Hydrocarbon Hydroxylases -- genetics KW - Aging -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70278203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Hepatic+transcript+levels+for+genes+coding+for+enzymes+associated+with+xenobiotic+metabolism+are+altered+with+age.&rft.au=Mori%2C+Kazuhiko%3BBlackshear%2C+Pamela+E%3BLobenhofer%2C+Edward+K%3BParker%2C+Joel+S%3BOrzech%2C+Denise+P%3BRoycroft%2C+Joseph+H%3BWalker%2C+Kimwa+L%3BJohnson%2C+Kennita+A%3BMarsh%2C+Tiwanda+A%3BIrwin%2C+Richard+D%3BBoorman%2C+Gary+A&rft.aulast=Mori&rft.aufirst=Kazuhiko&rft.date=2007-02-01&rft.volume=35&rft.issue=2&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-01 N1 - Date created - 2007-03-16 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - GSE4270; GEO N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene expression analysis offers unique advantages to histopathology in liver biopsy evaluations. AN - 70276342; 17366322 AB - Liver diseases that induce nonuniform lesions often give rise to greatly varying histopathology results in needle biopsy samples from the same patient. This study examines whether gene expression analysis of such biopsies could provide a more representative picture of the overall condition of the liver. We utilized acetaminophen (APAP) as a model hepatotoxicant that gives a multifocal pattern of necrosis following toxic doses. Rats were treated with a single toxic or subtoxic dose of APAP and sacrificed 6, 24, or 48 hours after exposure. Left liver lobes were harvested, and both gene expression and histopathological analysis were performed on biopsy-sized samples. While histopathological evaluation of such small samples revealed significant sample to sample differences after toxic doses of APAP, gene expression analysis provided a very homogeneous picture and allowed clear distinction between subtoxic and toxic doses. The main biological function differentiating animals that received sub-toxic from those that had received toxic doses was an acute stress response at 6 hours and signs of energy depletion at later time points. Our results suggest that the use of genomic analysis of biopsy samples together with histopathological analysis could provide a more precise representation of the overall condition of a patient's liver than histopathological evaluation alone. JF - Toxicologic pathology AU - Heinloth, Alexandra N AU - Boorman, Gary A AU - Foley, Julie F AU - Flagler, Norris D AU - Paules, Richard S AD - National Center for Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 276 EP - 283 VL - 35 IS - 2 SN - 0192-6233, 0192-6233 KW - Analgesics, Non-Narcotic KW - 0 KW - Acetaminophen KW - 362O9ITL9D KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Rats KW - Animals KW - Analgesics, Non-Narcotic -- adverse effects KW - Rats, Inbred F344 KW - Necrosis -- chemically induced KW - Dose-Response Relationship, Drug KW - Acetaminophen -- adverse effects KW - Cytochrome P-450 Enzyme System -- metabolism KW - Necrosis -- pathology KW - Biopsy KW - Necrosis -- metabolism KW - Male KW - Gene Expression Profiling KW - Liver -- pathology KW - Liver Diseases -- complications KW - Liver -- drug effects KW - Liver Diseases -- pathology KW - Liver -- metabolism KW - Liver Diseases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70276342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Gene+expression+analysis+offers+unique+advantages+to+histopathology+in+liver+biopsy+evaluations.&rft.au=Heinloth%2C+Alexandra+N%3BBoorman%2C+Gary+A%3BFoley%2C+Julie+F%3BFlagler%2C+Norris+D%3BPaules%2C+Richard+S&rft.aulast=Heinloth&rft.aufirst=Alexandra&rft.date=2007-02-01&rft.volume=35&rft.issue=2&rft.spage=276&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-01 N1 - Date created - 2007-03-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Toxicol Pathol. 2007;35(6):850 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cigarette smoking and quitting behaviors among unemployed adults in the United States. AN - 70272913; 17365755 AB - Little is known about factors associated with smoking among the unemployed. This study estimated the prevalence of smoking and examined sociodemographic factors associated with current, former, and successful quitting among unemployed adults aged 18-64. Cross-sectional data on 13,480 participants in the 1998-1999 and 2001-2002 Tobacco Use Supplements to the Current Population Surveys were analyzed. Multivariate logistic regression analyses were used to examine factors associated with study outcomes (current vs. never, former vs. current, successful quitter vs. other former smoker). Among the unemployed, 35% were current smokers and 13% were former smokers. Of the former smokers, 81% quit successfully for at least 12 months. Participants with family incomes of less than US$25,000 were more likely than those with incomes of $50,000 or more to currently smoke (OR=2.13, 95% CI=1.85-2.46). Service workers and blue-collar workers were less likely than white-collar workers to report former smoking. Participants unemployed for 6 months or more were twice as likely as those unemployed for less than 6 months to quit successfully (OR=2.05, 95% CI=1.07-3.95). Unemployed blue-collar workers had a greater odds ratio of successfully quitting than white-collar workers (OR=1.83, 95% CI=1.17-2.87). Smoking rates were high among the unemployed, and quitting behaviors varied by sociodemographic factors and length of unemployment. Studies are needed to examine the feasibility of cessation interventions for the unemployed. JF - Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco AU - Fagan, Pebbles AU - Shavers, Vickie AU - Lawrence, Deirdre AU - Gibson, James Todd AU - Ponder, Paris AD - National Cancer Institute, Tobacco Control Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, Bethesda, MD 20892, USA. faganp@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 241 EP - 248 VL - 9 IS - 2 SN - 1462-2203, 1462-2203 KW - Index Medicus KW - Behavior KW - Humans KW - Adult KW - Middle Aged KW - Workplace KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Prevalence KW - Multivariate Analysis KW - Tobacco Use Disorder -- epidemiology KW - Tobacco Use Disorder -- psychology KW - Unemployment -- statistics & numerical data KW - Unemployment -- psychology KW - Smoking -- psychology KW - Smoking -- epidemiology KW - Smoking Cessation -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70272913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=Cigarette+smoking+and+quitting+behaviors+among+unemployed+adults+in+the+United+States.&rft.au=Fagan%2C+Pebbles%3BShavers%2C+Vickie%3BLawrence%2C+Deirdre%3BGibson%2C+James+Todd%3BPonder%2C+Paris&rft.aulast=Fagan&rft.aufirst=Pebbles&rft.date=2007-02-01&rft.volume=9&rft.issue=2&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=14622203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-05 N1 - Date created - 2007-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Functional deficiency in IL-7 caused by an N-ethyl-N-nitrosourea-induced point mutation. AN - 70207183; 17179092 AB - N-ethyl-N-nitrosourea (ENU)-induced mutagenesis provides a powerful approach for identifying genes involved in immune regulation and diseases. Here we describe a new mutant strain, HLB368, with hereditary leukopenia. At necropsy, the mutant mice had very small thymuses and spleens. All but the inguinal nodes were absent and there were no Peyer's patches. By flow cytometry, the ratios of T-cell subsets were normal, but B-cell development was blocked at the pre-pro-B-cell stage. The development of B1 and marginal zone B cells was relatively normal. The mutation was mapped to chromosome 3 between D3Mit221 and D3Mit224, a region that contains the Il7 gene. cDNA and genomic DNA sequences of Il7 revealed a T-to-C missense transition resulting in a change of Leu to Pro within the leader peptide that would be predicted to inhibit secretion. In keeping with this concept, we found that in vitro treatment of B-cell progenitors from mutant mice with IL-7 induced them to differentiate into pre-BII cells. Phenotypic comparisons of HLB368 with genetically targeted Il7 null mice showed many similarities along with a few differences, indicating that this ENU-induced mutant carries a novel allele. This new strain thus provides a new model for studying the functions of IL-7 on a pure C57BL/6 background. JF - Genetics AU - Feng, Jianxun AU - Wang, Hongsheng AU - Morse, Herbert C AD - Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 545 EP - 551 VL - 175 IS - 2 SN - 0016-6731, 0016-6731 KW - Interleukin-7 KW - 0 KW - Ethylnitrosourea KW - P8M1T4190R KW - Index Medicus KW - T-Lymphocyte Subsets -- cytology KW - Thymus Gland -- cytology KW - Animals KW - B-Lymphocytes -- cytology KW - Cell Count KW - Spleen -- cytology KW - Mice KW - Chromosome Mapping KW - Thymus Gland -- drug effects KW - Lymphoid Tissue -- abnormalities KW - Phenotype KW - Lymphocyte Activation -- drug effects KW - B-Lymphocytes -- drug effects KW - Mice, Mutant Strains KW - Base Sequence KW - Lymphocyte Activation -- immunology KW - Myeloid Cells -- cytology KW - Molecular Sequence Data KW - Flow Cytometry KW - Bone Marrow Cells -- cytology KW - Spleen -- drug effects KW - Myeloid Cells -- drug effects KW - Cell Differentiation -- drug effects KW - Lymphoid Tissue -- drug effects KW - Point Mutation -- genetics KW - Interleukin-7 -- metabolism KW - Interleukin-7 -- deficiency KW - Interleukin-7 -- genetics KW - Ethylnitrosourea -- pharmacology KW - Mutagenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70207183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genetics&rft.atitle=Functional+deficiency+in+IL-7+caused+by+an+N-ethyl-N-nitrosourea-induced+point+mutation.&rft.au=Feng%2C+Jianxun%3BWang%2C+Hongsheng%3BMorse%2C+Herbert+C&rft.aulast=Feng&rft.aufirst=Jianxun&rft.date=2007-02-01&rft.volume=175&rft.issue=2&rft.spage=545&rft.isbn=&rft.btitle=&rft.title=Genetics&rft.issn=00166731&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-03 N1 - Date created - 2007-02-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 2000 Feb 15;164(4):1961-70 [10657646] J Immunol. 2006 Sep 1;177(5):2749-54 [16920907] Mamm Genome. 2000 Jul;11(7):594-7 [10886029] Immunity. 2001 May;14(5):617-29 [11371363] J Immunol. 2001 Aug 1;167(3):1254-62 [11466341] J Exp Med. 2001 Oct 15;194(8):1141-50 [11602642] Nat Genet. 2002 Mar;30(3):255-6 [11850622] Nat Rev Immunol. 2002 May;2(5):323-35 [12033738] Mol Immunol. 2003 Jan;39(12):753-60 [12531286] Nat Immunol. 2003 Aug;4(8):773-9 [12872121] Eur J Immunol. 2004 Oct;34(10):2642-6 [15368279] J Exp Med. 1988 Mar 1;167(3):988-1002 [3258354] Nature. 1988 Jun 9;333(6173):571-3 [3259677] J Leukoc Biol. 1990 Sep;48(3):205-12 [2144014] Cell. 1992 May 29;69(5):823-31 [1591779] J Exp Med. 1993 Jul 1;178(1):257-64 [8315381] J Exp Med. 1993 Sep 1;178(3):1109-14 [8350050] Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9125-9 [8415665] Cell. 1994 Jun 3;77(5):737-47 [8205622] J Exp Med. 1994 Nov 1;180(5):1955-60 [7964471] J Exp Med. 1995 Apr 1;181(4):1519-26 [7699333] J Clin Invest. 1995 Jun;95(6):2945-53 [7769137] Genes Dev. 1995 Sep 15;9(18):2203-13 [7557375] Immunology. 1997 Nov;92(3):374-80 [9486111] Nat Genet. 1998 Dec;20(4):394-7 [9843216] J Exp Med. 1999 Jan 18;189(2):319-30 [9892614] Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3000-5 [10077626] Eur J Immunol. 2004 Dec;34(12):3595-603 [15495160] J Immunol. 2005 Jun 1;174(11):6571-6 [15905493] Immunity. 2005 Sep;23(3):297-308 [16169502] Mol Immunol. 2006 Feb;43(4):326-34 [16310046] Semin Immunol. 2006 Feb;18(1):20-30 [16303314] Genesis. 2000 Feb;26(2):99-109 [10686599] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mechanism of ad5 vaccine immunity and toxicity: fiber shaft targeting of dendritic cells. AN - 70204518; 17319743 AB - Recombinant adenoviral (rAd) vectors elicit potent cellular and humoral immune responses and show promise as vaccines for HIV-1, Ebola virus, tuberculosis, malaria, and other infections. These vectors are now widely used and have been generally well tolerated in vaccine and gene therapy clinical trials, with many thousands of people exposed. At the same time, dose-limiting adverse responses have been observed, including transient low-grade fevers and a prior human gene therapy fatality, after systemic high-dose recombinant adenovirus serotype 5 (rAd5) vector administration in a human gene therapy trial. The mechanism responsible for these effects is poorly understood. Here, we define the mechanism by which Ad5 targets immune cells that stimulate adaptive immunity. rAd5 tropism for dendritic cells (DCs) was independent of the coxsackievirus and adenovirus receptor (CAR), its primary receptor or the secondary integrin RGD receptor, and was mediated instead by a heparin-sensitive receptor recognized by a distinct segment of the Ad5 fiber, the shaft. rAd vectors with CAR and RGD mutations did not infect a variety of epithelial and fibroblast cell types but retained their ability to transfect several DC types and stimulated adaptive immune responses in mice. Notably, the pyrogenic response to the administration of rAd5 also localized to the shaft region, suggesting that this interaction elicits both protective immunity and vector-induced fevers. The ability of replication-defective rAd5 viruses to elicit potent immune responses is mediated by a heparin-sensitive receptor that interacts with the Ad5 fiber shaft. Mutant CAR and RGD rAd vectors target several DC and mononuclear subsets and induce both adaptive immunity and toxicity. Understanding of these interactions facilitates the development of vectors that target DCs through alternative receptors that can improve safety while retaining the immunogenicity of rAd vaccines. JF - PLoS pathogens AU - Cheng, Cheng AU - Gall, Jason G D AU - Kong, Wing-pui AU - Sheets, Rebecca L AU - Gomez, Phillip L AU - King, C Richter AU - Nabel, Gary J AD - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 1 VL - 3 IS - 2 KW - Receptors, Immunologic KW - 0 KW - Receptors, Peptide KW - Receptors, Virus KW - Viral Proteins KW - Viral Vaccines KW - adenovirus receptor KW - arginyl-glycyl-aspartic acid directed cell adhesion receptor KW - Index Medicus KW - Viral Proteins -- immunology KW - Viral Proteins -- therapeutic use KW - Animals KW - Viral Proteins -- adverse effects KW - Dose-Response Relationship, Drug KW - Humans KW - Receptors, Immunologic -- physiology KW - Transduction, Genetic KW - Receptors, Peptide -- physiology KW - Receptors, Virus -- genetics KW - Mice KW - Rabbits KW - Virus Replication -- physiology KW - Mice, Inbred BALB C KW - Receptors, Immunologic -- genetics KW - Receptors, Virus -- physiology KW - Genetic Vectors KW - Receptors, Peptide -- genetics KW - Mutation KW - Female KW - Adenoviridae Infections -- immunology KW - Dendritic Cells -- pathology KW - Adenoviridae -- immunology KW - Adenoviridae -- pathogenicity KW - Dendritic Cells -- virology KW - Viral Vaccines -- adverse effects KW - Adenoviridae Infections -- prevention & control KW - Viral Vaccines -- immunology KW - Viral Vaccines -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70204518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+pathogens&rft.atitle=Mechanism+of+ad5+vaccine+immunity+and+toxicity%3A+fiber+shaft+targeting+of+dendritic+cells.&rft.au=Cheng%2C+Cheng%3BGall%2C+Jason+G+D%3BKong%2C+Wing-pui%3BSheets%2C+Rebecca+L%3BGomez%2C+Phillip+L%3BKing%2C+C+Richter%3BNabel%2C+Gary+J&rft.aulast=Cheng&rft.aufirst=Cheng&rft.date=2007-02-01&rft.volume=3&rft.issue=2&rft.spage=e25&rft.isbn=&rft.btitle=&rft.title=PLoS+pathogens&rft.issn=1553-7374&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-26 N1 - Date created - 2007-02-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 1999 Dec;73(12):10245-53 [10559341] J Exp Med. 1992 Dec 1;176(6):1693-702 [1460426] Science. 1999 Nov 19;286(5444):1579-83 [10567268] Virology. 2000 Mar 15;268(2):382-90 [10704346] Virology. 2000 Aug 15;274(1):1-4 [10936081] J Virol. 2001 Mar;75(6):2972-81 [11222722] J Virol. 2001 Sep;75(18):8772-80 [11507222] J Virol. 2001 Dec;75(23):11284-91 [11689608] Hum Gene Ther. 2002 Jan 1;13(1):163-75 [11779420] Cancer Immunol Immunother. 2003 Jun;52(6):347-58 [12739067] Cell. 1993 Apr 23;73(2):309-19 [8477447] Structure. 1994 Dec 15;2(12):1259-70 [7704534] J Virol. 1996 Nov;70(11):7498-509 [8892868] Science. 1997 Feb 28;275(5304):1320-3 [9036860] Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3352-6 [9096397] J Virol. 1997 Jun;71(6):4782-90 [9151872] Blood. 1998 Jan 15;91(2):392-8 [9427691] Hum Gene Ther. 1999 Apr 10;10(6):965-76 [10223730] J Virol. 2005 Jan;79(2):1053-61 [15613334] Hum Gene Ther. 2005 Feb;16(2):149-56 [15761255] Blood. 2005 May 15;105(10):3824-32 [15671441] J Immunol. 2005 Nov 1;175(9):6032-41 [16237098] Hum Gene Ther. 2006 Mar;17(3):264-79 [16544976] J Virol. 1999 Nov;73(11):9508-14 [10516059] Hum Gene Ther. 2003 May 20;14(8):777-87 [12804140] Mol Genet Metab. 2003 Sep-Oct;80(1-2):148-58 [14567964] Annu Rev Med. 2004;55:355-72 [14746526] J Virol. 2004 Mar;78(5):2572-80 [14963160] Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6200-5 [15071185] J Virol. 2004 May;78(10):5368-81 [15113916] Viral Immunol. 2004;17(2):182-96 [15279698] Mol Ther. 2004 Oct;10(4):616-29 [15451446] Immunol Today. 1992 Jun;13(6):231-6 [1378280] Science. 1999 Nov 19;286(5444):1568-71 [10567265] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nuclear receptors and chromatin remodeling machinery. AN - 69037061; 17240047 AB - Eukaryotic genetic information is stored within the association of DNA and histone proteins resulting in a dynamic polymer called chromatin. The fundamental structural unit of chromatin is the nucleosome which consists of approximately 146 bp of DNA wrapped around an octamer of histones containing two copies each of four core histones, H2A, H2B, H3 and H4. It is this DNA/protein fiber that transcription factors and other agents of chromatin metabolism must access and regulate. We have developed model systems to study the mechanisms by which steroid receptors control physiological activities by regulating gene expression within a higher order chromatin organization. Our studies have focused on the glucocorticoid receptor and its ability to remodel chromatin which is mediated by the BRG1 complex. Using novel cell systems, we demonstrate that GR-mediated transactivation from chromatin templates requires BRG1 remodeling activity and that other ATP-dependent remodeling proteins cannot substitute for this activity. JF - Molecular and cellular endocrinology AU - Trotter, Kevin W AU - Archer, Trevor K AD - Chromatin and Gene Expression Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, P.O. Box 12233 (MD C4-06), Research Triangle Park, NC 27709, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 162 EP - 167 VL - 265-266 SN - 0303-7207, 0303-7207 KW - Chromosomal Proteins, Non-Histone KW - 0 KW - Histones KW - Receptors, Glucocorticoid KW - SWI-SNF-B chromatin-remodeling complex KW - Transcription Factors KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Index Medicus KW - Animals KW - Humans KW - Histones -- metabolism KW - Adenosine Triphosphate -- metabolism KW - Chromosomal Proteins, Non-Histone -- metabolism KW - Transcriptional Activation KW - Transcription Factors -- metabolism KW - Chromatin Assembly and Disassembly KW - Receptors, Glucocorticoid -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69037061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+endocrinology&rft.atitle=Nuclear+receptors+and+chromatin+remodeling+machinery.&rft.au=Trotter%2C+Kevin+W%3BArcher%2C+Trevor+K&rft.aulast=Trotter&rft.aufirst=Kevin&rft.date=2007-02-01&rft.volume=265-266&rft.issue=&rft.spage=162&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+endocrinology&rft.issn=03037207&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-06 N1 - Date created - 2007-02-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell. 1999 Feb;3(2):239-45 [10078206] Genes Dev. 2003 Nov 15;17(22):2733-40 [14630937] Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15603-8 [15501915] Vitam Horm. 2005;70:281-307 [15727808] Mol Cell. 2005 Mar 18;17(6):805-15 [15780937] Genes Dev. 2005 Jul 15;19(14):1662-7 [15985610] Nat Struct Mol Biol. 2006 Jan;13(1):22-9 [16341228] Chromosome Res. 2006;14(1):83-94 [16506098] J Biol Chem. 2006 Aug 11;281(32):22656-64 [16769725] Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12457-62 [16895995] Curr Opin Genet Dev. 2000 Apr;10(2):187-92 [10753786] J Biol Chem. 2000 Jun 9;275(23):17771-7 [10748103] Mol Cell Biol. 2000 Dec;20(23):8879-88 [11073988] Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13015-20 [11078522] Cell. 2001 Mar 9;104(5):631-4 [11257215] Oncogene. 2001 May 28;20(24):3166-73 [11420733] EMBO J. 2001 Jul 16;20(14):3781-8 [11447119] Front Biosci. 2001 Sep 1;6:D1054-64 [11532604] Mol Cell. 2001 Dec;8(6):1219-30 [11779498] Nature. 2001 Dec 20-27;414(6866):924-8 [11780067] Curr Opin Genet Dev. 2002 Apr;12(2):142-8 [11893486] EMBO J. 2002 Aug 1;21(15):4094-103 [12145209] Biochim Biophys Acta. 2002 Oct 2;1603(1):19-29 [12242108] J Biol Chem. 2002 Nov 1;277(44):41674-85 [12200431] Cell. 2002 Nov 1;111(3):369-79 [12419247] J Steroid Biochem Mol Biol. 2003 Dec;87(4-5):223-31 [14698202] Biochim Biophys Acta. 2004 Mar 15;1677(1-3):30-45 [15020043] J Cell Biochem. 2004 Apr 15;91(6):1087-98 [15048866] Mol Cell Biol. 2004 Apr;24(8):3347-58 [15060156] Essays Biochem. 2004;40:73-88 [15242340] J Cell Sci. 2004 Aug 1;117(Pt 17):3707-11 [15286171] Genes Dev. 2004 Oct 15;18(20):2437-68 [15489290] Science. 1992 Mar 20;255(5051):1573-6 [1347958] Science. 1992 Dec 4;258(5088):1598-604 [1360703] EMBO J. 1993 Nov;12(11):4279-90 [8223438] Mol Cell Biol. 1994 Apr;14(4):2225-34 [7908117] Nucleic Acids Res. 1994 May 25;22(10):1815-20 [8208605] Genes Dev. 1996 Sep 1;10(17):2117-30 [8804307] EMBO J. 1996 Oct 1;15(19):5370-82 [8895581] Gene. 1997 Mar 25;188(1):95-100 [9099865] Nature. 1998 May 7;393(6680):88-91 [9590696] Mol Cell. 2002 Dec;10(6):1441-52 [12504018] Nature. 2003 Jan 23;421(6921):448-53 [12540921] Cell. 2003 Apr 18;113(2):207-19 [12705869] EMBO J. 2003 May 1;22(9):2146-55 [12727881] Mol Cell. 2003 May;11(5):1311-22 [12769854] Genes Dev. 2003 Jun 1;17(11):1392-401 [12782657] Recent Prog Horm Res. 2003;58:199-226 [12795420] Cell. 2003 Jun 27;113(7):905-17 [12837248] Mol Cell Biol. 2003 Sep;23(17):6210-20 [12917342] Cell. 2003 Nov 14;115(4):425-35 [14622597] Mol Cell. 1999 Feb;3(2):247-53 [10078207] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characterization of polVR391: a Y-family polymerase encoded by rumA'B from the IncJ conjugative transposon, R391. AN - 69011117; 17302804 AB - Although best characterized for their ability to traverse a variety of DNA lesions, Y-family DNA polymerases can also give rise to elevated spontaneous mutation rates if they are allowed to replicate undamaged DNA. One such enzyme that promotes high levels of spontaneous mutagenesis in Escherichia coli is polV(R391), a polV-like Y-family polymerase encoded by rumA'B from the IncJ conjugative transposon R391. When expressed in a DeltaumuDC lexA(Def) recA730 strain, polV(R391) promotes higher levels of spontaneous mutagenesis than the related MucA'B (polR1) or UmuD'C (polV) polymerases respectively. Analysis of the spectrum of polV(R391)-dependent mutations in rpoB revealed a unique genetic fingerprint that is typified by an increase in C:G-->A:T and A:T-->T:A transversions at certain mutagenic hot spots. Biochemical characterization of polV(R391) highlights the exceptional ability of the enzyme to misincorporate T opposite C and T in sequence contexts corresponding to mutagenic hot spots. Purified polV(R391) can also bypass a T-T pyrimidine dimer efficiently and displays greater accuracy opposite the 3'T of the dimer than opposite an undamaged T. Our study therefore provides evidence for the molecular basis for the enhanced spontaneous mutator activity of RumA'B, as well as explains its ability to promote efficient and accurate bypass of T-T pyrimidine dimers in vivo. JF - Molecular microbiology AU - Mead, Samantha AU - Vaisman, Alexandra AU - Valjavec-Gratian, Majda AU - Karata, Kiyonobu AU - Vandewiele, Dominique AU - Woodgate, Roger AD - Laboratory of Genomic Integrity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-2725, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 797 EP - 810 VL - 63 IS - 3 SN - 0950-382X, 0950-382X KW - DNA Transposable Elements KW - 0 KW - Escherichia coli Proteins KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - polV(R391) protein, E coli KW - Index Medicus KW - Gene Expression Regulation, Bacterial KW - SOS Response (Genetics) KW - Mutagenesis KW - Escherichia coli Proteins -- metabolism KW - Escherichia coli -- genetics KW - Escherichia coli -- enzymology KW - DNA-Directed DNA Polymerase -- genetics KW - Escherichia coli Proteins -- genetics KW - DNA-Directed DNA Polymerase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69011117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+microbiology&rft.atitle=Characterization+of+polVR391%3A+a+Y-family+polymerase+encoded+by+rumA%27B+from+the+IncJ+conjugative+transposon%2C+R391.&rft.au=Mead%2C+Samantha%3BVaisman%2C+Alexandra%3BValjavec-Gratian%2C+Majda%3BKarata%2C+Kiyonobu%3BVandewiele%2C+Dominique%3BWoodgate%2C+Roger&rft.aulast=Mead&rft.aufirst=Samantha&rft.date=2007-02-01&rft.volume=63&rft.issue=3&rft.spage=797&rft.isbn=&rft.btitle=&rft.title=Molecular+microbiology&rft.issn=0950382X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-13 N1 - Date created - 2007-02-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1). AN - 69009138; 17301694 AB - Cyclooxygenase-1 (COX-1, PTGS1) catalyzes the conversion of arachidonic acid to prostaglandin H2, which is subsequently metabolized to various biologically active prostaglandins. We sought to identify and characterize the functional relevance of genetic polymorphisms in PTGS1. Sequence variations in human PTGS1 were identified by resequencing 92 healthy individuals (24 African, 24 Asian, 24 European/Caucasian, and 20 anonymous). Using site-directed mutagenesis and a baculovirus/insect cell expression system, recombinant wild-type COX-1 and the R8W, P17L, R53H, R78W, K185T, G230S, L237M, and V481I variant proteins were expressed. COX-1 metabolic activity was evaluated in vitro using an oxygen consumption assay under basal conditions and in the presence of indomethacin. Forty-five variants were identified, including seven nonsynonymous polymorphisms encoding amino acid substitutions in the COX-1 protein. The R53H (35+/-5%), R78W (36+/-4%), K185T (59+/-6%), G230S (57+/-4%), and L237M (51+/-3%) variant proteins had significantly lower metabolic activity relative to wild-type (100+/-7%), while no significant differences were observed with the R8W (104+/-10%), P17L (113+/-7%), and V481I (121+/-10%) variants. Inhibition studies with indomethacin demonstrated that the P17L and G230S variants had significantly lower IC50 values compared to wild-type, suggesting these variants significantly increase COX-1 sensitivity to indomethacin inhibition. Consistent with the metabolic activity data, protein modeling suggested the G230S variant may disrupt the active conformation of COX-1. Our findings demonstrate that several genetic variants in human COX-1 significantly alter basal COX-1-mediated arachidonic acid metabolism and indomethacin-mediated inhibition of COX-1 activity in vitro. Future studies characterizing the functional impact of these variants in vivo are warranted. JF - Pharmacogenetics and genomics AU - Lee, Craig R AU - Bottone, Frank G AU - Krahn, Joseph M AU - Li, Leping AU - Mohrenweiser, Harvey W AU - Cook, Molly E AU - Petrovich, Robert M AU - Bell, Douglas A AU - Eling, Thomas E AU - Zeldin, Darryl C AD - Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Chapel Hill, North Carolina, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 145 EP - 160 VL - 17 IS - 2 SN - 1744-6872, 1744-6872 KW - Enzyme Inhibitors KW - 0 KW - Membrane Proteins KW - Mutant Proteins KW - Arachidonic Acid KW - 27YG812J1I KW - Cyclooxygenase 1 KW - EC 1.14.99.1 KW - PTGS1 protein, human KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Mutant Proteins -- genetics KW - Protein Structure, Secondary KW - Mutant Proteins -- metabolism KW - Humans KW - Dimerization KW - Molecular Sequence Data KW - Enzyme Inhibitors -- pharmacology KW - Microsomes -- enzymology KW - Amino Acid Sequence KW - Inhibitory Concentration 50 KW - Linkage Disequilibrium KW - Arachidonic Acid -- metabolism KW - Polymorphism, Single Nucleotide KW - Cyclooxygenase 1 -- chemistry KW - Membrane Proteins -- chemistry KW - Cyclooxygenase 1 -- metabolism KW - Membrane Proteins -- metabolism KW - Membrane Proteins -- antagonists & inhibitors KW - Cyclooxygenase 1 -- genetics KW - Membrane Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69009138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenetics+and+genomics&rft.atitle=Identification+and+functional+characterization+of+polymorphisms+in+human+cyclooxygenase-1+%28PTGS1%29.&rft.au=Lee%2C+Craig+R%3BBottone%2C+Frank+G%3BKrahn%2C+Joseph+M%3BLi%2C+Leping%3BMohrenweiser%2C+Harvey+W%3BCook%2C+Molly+E%3BPetrovich%2C+Robert+M%3BBell%2C+Douglas+A%3BEling%2C+Thomas+E%3BZeldin%2C+Darryl+C&rft.aulast=Lee&rft.aufirst=Craig&rft.date=2007-02-01&rft.volume=17&rft.issue=2&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Pharmacogenetics+and+genomics&rft.issn=17446872&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-24 N1 - Date created - 2007-02-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochim Biophys Acta. 1999 Nov 23;1441(2-3):278-87 [10570255] Clin Pharmacol Ther. 2006 May;79(5):407-18 [16678543] Nature. 2000 May 4;405(6782):97-101 [10811226] J Biol Chem. 2001 Mar 30;276(13):10347-57 [11121412] J Pharmacol Exp Ther. 2001 Nov;299(2):468-76 [11602656] Mol Pharmacol. 2002 Apr;61(4):840-52 [11901223] J Pharmacol Exp Ther. 2002 Jun;301(3):1126-31 [12023546] Blood Coagul Fibrinolysis. 2002 Sep;13(6):519-31 [12192304] Arterioscler Thromb Vasc Biol. 2002 Oct 1;22(10):1631-6 [12377741] Hum Mutat. 2002 Nov;20(5):409-10 [12402351] Clin Pharmacol Ther. 2003 Jan;73(1):122-30 [12545150] Nucleic Acids Res. 2003 Jul 1;31(13):3497-500 [12824352] Mol Pharmacol. 2003 Aug;64(2):482-90 [12869654] Thromb Res. 2003;112(5-6):275-83 [15041270] FASEB J. 2004 May;18(7):790-804 [15117884] JAMA. 2004 May 12;291(18):2221-8 [15138244] Cancer Epidemiol Biomarkers Prev. 2004 May;13(5):889-93 [15159324] Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W615-9 [15215462] Biochem Biophys Res Commun. 1989 Dec 15;165(2):888-94 [2512924] J Biol Chem. 1990 Nov 25;265(33):20073-6 [2122967] Biochem Biophys Res Commun. 1993 Jan 29;190(2):406-11 [8427584] Nature. 1994 Jan 20;367(6460):243-9 [8121489] Biochim Biophys Acta. 1994 Nov 16;1209(1):130-9 [7947975] Biochem J. 1995 Jan 15;305 ( Pt 2):479-84 [7832763] J Biol Chem. 1996 Jan 26;271(4):2179-84 [8567676] J Comput Biol. 1994 Fall;1(3):191-8 [8790464] Nature. 1996 Dec 19-26;384(6610):644-8 [8967954] J Biol Chem. 1996 Dec 27;271(52):33157-60 [8969167] Genome Res. 1998 Dec;8(12):1229-31 [9872978] Bioinformatics. 2005 Jan 15;21(2):263-5 [15297300] J Pharmacol Exp Ther. 2005 Aug;314(2):923-31 [15914676] Eur Respir J. 2005 Aug;26(2):249-56 [16055872] Circulation. 2005 Aug 2;112(5):759-70 [16061757] J Thromb Haemost. 2005 Oct;3(10):2340-5 [16150050] J Clin Invest. 2006 Jan;116(1):4-15 [16395396] Gastroenterology. 2006 Jan;130(1):55-64 [16401468] J Biol Chem. 2000 Mar 24;275(12):8501-7 [10722687] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Residual tobacco smoke: measurement of its washout time in the lung and of its contribution to environmental tobacco smoke. AN - 69002091; 17297070 AB - Tobacco smoking entails inhaling millions of fine particles with each puff, and it is intuitive that after smoking a cigarette it will take a certain time to washout residual tobacco smoke (RTS) from the lungs with subsequent breaths. To study the washout time of 0.3-1.0 microm particles after the last puff in 10 volunteer smokers by using equipment capable of measuring particle concentration in real time in the exhaled air. Mean (standard deviation (SD)) lung RTS washout time was 58.6 (23.6) s, range 18-90 s, and corresponded to 8.7 (4.6) subsequent breathings. The contribution of individual and overall RTS to indoor pollution was calculated by subtracting incremental background particle concentration from room concentration after 10 consecutive re-entries of smokers after the last puff into a room of 33.2 m3, with an air exchange rate per hour in the range of 0.2-0.4. Mean (SD) individual RTS contribution consisted of 1402 (1490) million particles (range 51-3611 million), whereas RTS increased room 0.3-1.0 microm particle concentration from a baseline of 22,283 particles/l to a final room concentration of 341,956 particles/l, corresponding to a total increase in particulate matter (2.5) from a background of 0.56 up to 3.32 microg/m3. These data reveal a definite although marginal, role of RTS as a source of hidden indoor pollution. Further studies are needed to understand the relevance of this contribution in smoke-free premises in terms of risk exposure; however, waiting for about 2 min before re-entry after the last puff would be enough to avoid an unwanted additional exposure for non-smokers. JF - Tobacco control AU - Invernizzi, Giovanni AU - Ruprecht, Ario AU - De Marco, Cinzia AU - Paredi, Paolo AU - Boffi, Roberto AD - Tobacco Control Unit, National Cancer Institute and SIMG Italian College GPs, Milan, Italy. ginverni@clavis.it Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 29 EP - 33 VL - 16 IS - 1 KW - Air Pollutants KW - 0 KW - Tobacco Smoke Pollution KW - Index Medicus KW - Smoking KW - Particle Size KW - Humans KW - Exhalation KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Italy KW - Female KW - Air Pollution, Indoor -- analysis KW - Air Pollutants -- pharmacokinetics KW - Tobacco Smoke Pollution -- analysis KW - Lung -- metabolism KW - Air Pollutants -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69002091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tobacco+control&rft.atitle=Residual+tobacco+smoke%3A+measurement+of+its+washout+time+in+the+lung+and+of+its+contribution+to+environmental+tobacco+smoke.&rft.au=Invernizzi%2C+Giovanni%3BRuprecht%2C+Ario%3BDe+Marco%2C+Cinzia%3BParedi%2C+Paolo%3BBoffi%2C+Roberto&rft.aulast=Invernizzi&rft.aufirst=Giovanni&rft.date=2007-02-01&rft.volume=16&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Tobacco+control&rft.issn=1468-3318&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-07 N1 - Date created - 2007-02-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Epidemiology. 2000 Jan;11(1):6-10 [10615836] Inhal Toxicol. 2006 Apr;18(4):255-94 [22397322] Environ Health Perspect. 2002 Jul;110(7):689-98 [12117646] Eur Respir J. 2002 Jul;20(1):198-209 [12166570] Environ Health Perspect. 2003 Jul;111(9):1265-72 [12842784] Environ Health Perspect. 2004 Jun;112(8):932-41 [15175185] Tob Control. 2004 Sep;13(3):219-21 [15333875] Inhal Toxicol. 2004 Sep;16(10):675-89 [15371056] Science. 1980 May 2;208(4443):464-72 [7367873] Environ Health Perspect. 1996 Oct;104 Suppl 5:861-9 [8933027] Am Ind Hyg Assoc J. 1999 May-Jun;60(3):334-9 [10386354] Circulation. 2005 May 24;111(20):2684-98 [15911719] Environ Health Perspect. 2005 Sep;113(9):1140-7 [16140618] BMJ. 2005 Nov 12;331(7525):1117 [16230313] Biomarkers. 2006 May-Jun;11(3):221-32 [16760131] Epidemiol Prev. 2002 Jan-Feb;26(1):30-4 [11942144] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A pilot study of CTLA-4 blockade after cancer vaccine failure in patients with advanced malignancy. AN - 68993245; 17289891 AB - Eleven patients with progressive advanced malignancy after administration of a cancer vaccine received a fully human anti-CTLA-4 monoclonal antibody (ipilimumab). The primary end point was to determine drug toxicity. Tumor response, tumor-specific CD8+ T-cell immune responses, and modulation of CD4+ CD25+ FoxP3+ regulatory T-cell (Treg) numbers were secondary end points. Three patients with colon cancer, four with non-Hodgkin's lymphoma, and four with prostate cancer were treated. The first dose was given at 3 mg/kg and subsequent doses were administered monthly at 1.5 mg/kg for a total of four cycles. Tumor regression was observed in two patients with lymphoma; one of which obtained a partial response of 14-month duration. Ipilimumab was well tolerated with predominantly grade 1/2 toxicities. One drug-related grade 3 toxicity was observed. One patient died within 30 days of treatment due to progressive colon cancer. No increase in vaccine-specific T-cell responses was observed after therapy. Tregs as detected by expression of CD4+CD25+CD62L+ declined at early time points but rebounded to levels at or above baseline values at the time of the next infusion. Ipilimumab treatment depressed Treg numbers at early time points in the treatment cycle but was not accompanied by an increase in vaccine-specific CD8+ T-cell responses in these patients previously treated with a variety of investigational anticancer vaccines. A partial response was observed in one patient with follicular lymphoma. A phase I/II trial evaluating ipilimumab in patients with follicular lymphoma is currently ongoing. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - O'Mahony, Deirdre AU - Morris, John C AU - Quinn, Cate AU - Gao, Wendy AU - Wilson, Wyndham H AU - Gause, Barry AU - Pittaluga, Stefania AU - Neelapu, Sattva AU - Brown, Margaret AU - Fleisher, Thomas A AU - Gulley, James L AU - Schlom, Jeffrey AU - Nussenblatt, Robert AU - Albert, Paul AU - Davis, Thomas A AU - Lowy, Israel AU - Petrus, Mike AU - Waldmann, Thomas A AU - Janik, John E AD - Metabolism Branch, Laboratory of Pathology, Department of Laboratory Medicine, National Eye Institute, Bethesda, MD 20892-1457, USA. Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 958 EP - 964 VL - 13 IS - 3 SN - 1078-0432, 1078-0432 KW - Antigens, CD KW - 0 KW - Antigens, Differentiation KW - Antineoplastic Agents KW - CTLA-4 Antigen KW - CTLA4 protein, human KW - Cancer Vaccines KW - Interleukin-2 Receptor alpha Subunit KW - L-Selectin KW - 126880-86-2 KW - Prostate-Specific Antigen KW - EC 3.4.21.77 KW - Index Medicus KW - CD8-Positive T-Lymphocytes -- metabolism KW - Humans KW - Aged KW - Pilot Projects KW - Prostate-Specific Antigen -- biosynthesis KW - CD4-Positive T-Lymphocytes -- metabolism KW - Adult KW - L-Selectin -- biosynthesis KW - Neoplasm Metastasis KW - Middle Aged KW - Antineoplastic Agents -- pharmacology KW - Female KW - Male KW - Interleukin-2 Receptor alpha Subunit -- biosynthesis KW - Prostatic Neoplasms -- pathology KW - Lymphoma, Non-Hodgkin -- drug therapy KW - Antigens, Differentiation -- metabolism KW - Colonic Neoplasms -- drug therapy KW - Antigens, CD -- metabolism KW - Prostatic Neoplasms -- drug therapy KW - Colonic Neoplasms -- pathology KW - Lymphoma, Non-Hodgkin -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68993245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=A+pilot+study+of+CTLA-4+blockade+after+cancer+vaccine+failure+in+patients+with+advanced+malignancy.&rft.au=O%27Mahony%2C+Deirdre%3BMorris%2C+John+C%3BQuinn%2C+Cate%3BGao%2C+Wendy%3BWilson%2C+Wyndham+H%3BGause%2C+Barry%3BPittaluga%2C+Stefania%3BNeelapu%2C+Sattva%3BBrown%2C+Margaret%3BFleisher%2C+Thomas+A%3BGulley%2C+James+L%3BSchlom%2C+Jeffrey%3BNussenblatt%2C+Robert%3BAlbert%2C+Paul%3BDavis%2C+Thomas+A%3BLowy%2C+Israel%3BPetrus%2C+Mike%3BWaldmann%2C+Thomas+A%3BJanik%2C+John+E&rft.aulast=O%27Mahony&rft.aufirst=Deirdre&rft.date=2007-02-01&rft.volume=13&rft.issue=3&rft.spage=958&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-04 N1 - Date created - 2007-02-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Clin Cancer Res. 2007 Feb 1;13(3):785-8 [17289867] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Unraveling the complexities of the mechanism of action of dioxins. AN - 68992371; 17297723 JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Walker, Nigel J AD - National Institute of Environmental Health Sciences, National Institutes of Health, PO Box 12233, MD EC-34, 111 T. W. Alexander Drive, Research Triangle Park, North Carolina 27709, USA. walker3@niehs.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 297 EP - 299 VL - 95 IS - 2 SN - 1096-6080, 1096-6080 KW - Ligands KW - 0 KW - Polychlorinated Dibenzodioxins KW - Receptors, Aryl Hydrocarbon KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Species Specificity KW - Polychlorinated Dibenzodioxins -- toxicity KW - Receptors, Aryl Hydrocarbon -- metabolism KW - Receptors, Aryl Hydrocarbon -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68992371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Unraveling+the+complexities+of+the+mechanism+of+action+of+dioxins.&rft.au=Walker%2C+Nigel+J&rft.aulast=Walker&rft.aufirst=Nigel&rft.date=2007-02-01&rft.volume=95&rft.issue=2&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-05 N1 - Date created - 2007-02-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Toxicol Sci. 2006 Dec;94(2):398-416 [16960034] Toxicol Sci. 2006 Dec;94(2):428-38 [16984957] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer. AN - 68991051; 17287871 AB - Renal cell carcinoma (RCC) represents a group of diseases linked by their primary site of origin, the kidney. Studies of families with a genetic predisposition to the development of kidney cancer have revealed that multiple genes are involved in the molecular pathogenesis of RCC. Germline mutations in a gene that encodes a Krebs cycle enzyme have been found to result in a distinct clinical entity referred to as hereditary leiomyomatosis and renal cell cancer (HLRCC). HLRCC is inherited in an autosomal-dominant fashion. Affected individuals in HLRCC families are at risk for the development of leiomyomas of the skin and uterus as well as renal cancers. HLRCC-associated kidney tumors are often biologically aggressive. Linkage analysis has identified germline alterations in the fumarate hydratase (FH) gene associated with HLRCC. While the mechanisms of molecular carcinogenesis are not entirely understood, several lines of evidence derived from clinical and basic research suggest that pseudohypoxia might drive cellular transformation. The role of FH mutations in sporadic tumors seems to be limited. Nevertheless, continued investigation of HLRCC should provide further insight into the mechanisms of kidney cancer development, and could potentially identify targets for new therapeutic approaches to RCC. JF - Nature clinical practice. Urology AU - Sudarshan, Sunil AU - Pinto, Peter A AU - Neckers, Len AU - Linehan, W Marston AD - Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-1107, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 104 EP - 110 VL - 4 IS - 2 KW - Index Medicus KW - Humans KW - Kidney Neoplasms -- genetics KW - Carcinoma, Renal Cell -- pathology KW - Kidney Neoplasms -- pathology KW - Carcinoma, Renal Cell -- metabolism KW - Leiomyomatosis -- metabolism KW - Kidney Neoplasms -- metabolism KW - Leiomyomatosis -- genetics KW - Carcinoma, Renal Cell -- genetics KW - Leiomyomatosis -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68991051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+clinical+practice.+Urology&rft.atitle=Mechanisms+of+disease%3A+hereditary+leiomyomatosis+and+renal+cell+cancer--a+distinct+form+of+hereditary+kidney+cancer.&rft.au=Sudarshan%2C+Sunil%3BPinto%2C+Peter+A%3BNeckers%2C+Len%3BLinehan%2C+W+Marston&rft.aulast=Sudarshan&rft.aufirst=Sunil&rft.date=2007-02-01&rft.volume=4&rft.issue=2&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=Nature+clinical+practice.+Urology&rft.issn=1743-4289&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-30 N1 - Date created - 2007-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Expression of peroxisome proliferator-activated receptor-gamma in macrophage suppresses experimentally induced colitis. AN - 68990812; 17095756 AB - Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has been shown to be a protective transcription factor in mouse models of inflammatory bowel disease (IBD). PPAR-gamma is expressed in several different cell types, and mice with a targeted disruption of the PPAR-gamma gene in intestinal epithelial cells demonstrated increased susceptibility to dextran sulfate sodium (DSS)-induced IBD. However, the highly selective PPAR-gamma ligand rosiglitazone decreased the severity of DSS-induced colitis and suppressed cytokine production in both PPAR-gamma intestinal specific null mice and wild-type littermates. Therefore the role of PPAR-gamma in different tissues and their contribution to the pathogenesis of IBD still remain unclear. Mice with a targeted disruption of PPAR-gamma in macrophages (PPAR-gamma(DeltaMphi)) and wild-type littermates (PPAR-gamma(F/F)) were administered 2.5% DSS in drinking water to induce IBD. Typical clinical symptoms were evaluated on a daily basis, and proinflammatory cytokine analysis was performed. PPAR-gamma(DeltaMphi) mice displayed an increased susceptibility to DSS-induced colitis compared with wild-type littermates, as defined by body weight loss, diarrhea, rectal bleeding score, colon length, and histology. IL-1beta, CCR2, MCP-1, and inducible nitric oxide synthase mRNA levels in colons of PPAR-gamma(DeltaMphi) mice treated with DSS were higher than in similarly treated PPAR-gamma(F/F) mice. The present study has identified a novel protective role for macrophage PPAR-gamma in the DSS-induced IBD model. The data suggest that PPAR-gamma regulates recruitment of macrophages to inflammatory foci in the colon. JF - American journal of physiology. Gastrointestinal and liver physiology AU - Shah, Yatrik M AU - Morimura, Keiichirou AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - G657 EP - G666 VL - 292 IS - 2 SN - 0193-1857, 0193-1857 KW - Antigens, CD KW - 0 KW - Antigens, CD36 KW - Antigens, Differentiation, Myelomonocytic KW - CD68 protein, mouse KW - Ccr2 protein, mouse KW - Chemokine CCL2 KW - Cytokines KW - Fabp4 protein, mouse KW - Fatty Acid-Binding Proteins KW - Marco protein, mouse KW - PPAR gamma KW - RNA, Messenger KW - Receptors, CCR2 KW - Receptors, Chemokine KW - Receptors, Immunologic KW - Thiazolidinediones KW - rosiglitazone KW - 05V02F2KDG KW - Dextran Sulfate KW - 9042-14-2 KW - Nitric Oxide Synthase Type II KW - EC 1.14.13.39 KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Colon -- pathology KW - Fatty Acid-Binding Proteins -- genetics KW - Dextran Sulfate -- toxicity KW - RNA, Messenger -- genetics KW - Mice, Knockout KW - Neutrophils -- metabolism KW - Dendritic Cells -- metabolism KW - Receptors, Immunologic -- metabolism KW - Thiazolidinediones -- pharmacology KW - Chemokine CCL2 -- pharmacology KW - Cell Movement -- drug effects KW - Antigens, CD36 -- genetics KW - Receptors, Chemokine -- metabolism KW - Cytokines -- metabolism KW - Mice KW - Mice, Inbred Strains KW - Blotting, Western KW - RNA, Messenger -- metabolism KW - Colon -- metabolism KW - Body Weight -- drug effects KW - Antigens, CD -- metabolism KW - Antigens, Differentiation, Myelomonocytic -- metabolism KW - Nitric Oxide Synthase Type II -- metabolism KW - PPAR gamma -- metabolism KW - Colitis -- chemically induced KW - Macrophages -- drug effects KW - Colitis -- genetics KW - Colitis -- metabolism KW - PPAR gamma -- genetics KW - PPAR gamma -- agonists KW - Macrophages -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68990812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Gastrointestinal+and+liver+physiology&rft.atitle=Expression+of+peroxisome+proliferator-activated+receptor-gamma+in+macrophage+suppresses+experimentally+induced+colitis.&rft.au=Shah%2C+Yatrik+M%3BMorimura%2C+Keiichirou%3BGonzalez%2C+Frank+J&rft.aulast=Shah&rft.aufirst=Yatrik&rft.date=2007-02-01&rft.volume=292&rft.issue=2&rft.spage=G657&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Gastrointestinal+and+liver+physiology&rft.issn=01931857&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-16 N1 - Date created - 2007-02-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochimie. 1997 Feb-Mar;79(2-3):111-2 [9209705] Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4318-23 [9113987] J Pharmacol Exp Ther. 1998 Dec;287(3):1048-55 [9864291] J Clin Invest. 1999 Mar;103(6):773-8 [10079097] Atherosclerosis. 1999 Mar;143(1):205-11 [10208497] J Clin Invest. 1999 Aug;104(4):383-9 [10449430] Arterioscler Thromb Vasc Biol. 2004 Nov;24(11):1997-2008 [15319268] Curr Mol Med. 2004 Nov;4(7):763-75 [15579023] Eur J Pharmacol. 2005 Jan 31;508(1-3):255-65 [15680279] Inflamm Bowel Dis. 2005 Mar;11(3):231-43 [15735429] Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6207-12 [15833818] Biochem Biophys Res Commun. 2005 Jun 24;332(1):188-93 [15896316] Biochem Pharmacol. 2005 Jun 15;69(12):1733-44 [15876425] Mol Immunol. 2005 Jul;42(11):1303-10 [15950726] Int Immunol. 2005 Aug;17(8):1023-34 [16000328] Arterioscler Thromb Vasc Biol. 2005 Aug;25(8):1647-53 [15947238] Nature. 2005 Sep 29;437(7059):759-63 [16127449] Ann Allergy Asthma Immunol. 2005 Nov;95(5):468-73 [16312170] Gut. 2006 Aug;55(8):1104-13 [16547072] Mol Cell. 1999 Oct;4(4):611-7 [10549292] Scand J Gastroenterol. 1999 Nov;34(11):1117-22 [10582763] Transgenic Res. 1999 Aug;8(4):265-77 [10621974] J Immunol. 2000 Jun 15;164(12):6303-12 [10843684] J Clin Invest. 2000 Aug;106(4):467-72 [10953021] J Clin Invest. 2000 Sep;106(6):793-802 [10995790] Nat Med. 2001 Jan;7(1):48-52 [11135615] Eur J Clin Invest. 2001 Mar;31(3):234-9 [11264651] Eur Cytokine Netw. 2001 Mar;12(1):111-8 [11282554] Free Radic Biol Med. 2001 Jul 15;31(2):153-63 [11440827] J Exp Med. 2001 Nov 5;194(9):1207-18 [11696587] Mol Cell Biol. 2002 Apr;22(8):2607-19 [11909955] Arterioscler Thromb Vasc Biol. 2002 Nov 1;22(11):1924-8 [12426226] Dig Dis Sci. 2003 Feb;48(2):408-14 [12643623] Redox Rep. 2002;7(5):283-9 [12688511] J Gastroenterol. 2003 Mar;38 Suppl 15:59-62 [12698874] Gastroenterology. 2003 May;124(5):1265-76 [12730867] Gastroenterology. 2003 May;124(5):1315-24 [12730872] Proc Natl Acad Sci U S A. 2003 May 27;100(11):6712-7 [12740443] Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15712-7 [14660788] Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4543-7 [15070754] Am J Physiol Gastrointest Liver Physiol. 2004 Oct;287(4):G865-74 [15217783] Gastroenterology. 2004 Sep;127(3):777-91 [15362034] J Clin Invest. 1990 Sep;86(3):972-80 [2168444] Gastroenterology. 1992 Jul;103(1):65-71 [1535326] Lab Invest. 1993 Aug;69(2):238-49 [8350599] Gastroenterology. 1994 Feb;106(2):533-9 [8299918] Annu Rev Biochem. 1994;63:451-86 [7979245] Chem Biol Interact. 1995 May 19;96(2):203-6 [7728908] Am J Physiol. 1995 May;268(5 Pt 1):L699-722 [7762673] J Biol Chem. 1995 Jun 2;270(22):12953-6 [7768881] Gastroenterology. 1995 Oct;109(4):1344-67 [7557106] Cell. 1995 Dec 1;83(5):813-9 [8521498] Nature. 1998 Aug 27;394(6696):894-7 [9732872] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Leptin induces an Apc genotype-associated colon epithelial cell chemokine production pattern associated with macrophage chemotaxis and activation. AN - 68984431; 16891627 AB - Leptin is an adipocyte-derived cytokine associated with obesity and inflammation recently shown to influence colon epithelial cell fate and colon inflammation. Thus, the purpose of this study is to investigate the influences of leptin exposure on the production of proinflammatory signals by a model of normal [YAMC (Apc+/+)] and preneoplastic [IMCE (ApcMin/+)] colon epithelial cells. Here, we characterize the production of specific CC and CXC chemokines by IMCE and YAMC cells using an antibody-based cytokine array. Further, since epithelial cells are hypothesized to be accessory to the inflammatory response, we assessed the ability of supernants from leptin-exposed colon epithelial cells to activate macrophage chemotaxis and nitric oxide production. Both YAMC and IMCE cells produced the following chemokines from the CC family; MCP-1, MIP-3alpha, TCA-3, CTACK and RANTES. These cell lines also produced the following CXC chemokines; MIP-2, CXCL18, KC and LIX. Conditioned media from leptin-treated YAMC and IMCE cells induced nitric oxide production by macrophages (P<0.05). However, only conditioned media from leptin-treated IMCE cells induced macrophage chemotaxis (P<0.05). These data imply that preneoplastic but not normal cells may selectively attract immune cells that promote their survival and transformation. Taken together with our previous data, we conclude that leptin promotes the proliferation of a model of preneoplastic cells (IMCE) and induces the production of chemokines which may activate macrophages and promote macrophage cell chemotaxis. These data provide a rational basis for leptin-induced cross-talk between preneoplastic epithelial cells and immune cells that may influence the promotional phase of carcinogenesis. JF - Carcinogenesis AU - Fenton, Jenifer I AU - Hursting, Stephen D AU - Perkins, Susan N AU - Hord, Norman G AD - Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute Bethesda, MD, USA. imigjeni@msu.edu Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 455 EP - 464 VL - 28 IS - 2 SN - 0143-3334, 0143-3334 KW - Chemokines KW - 0 KW - Culture Media, Conditioned KW - Leptin KW - Index Medicus KW - Genotype KW - Epithelial Cells -- metabolism KW - Animals KW - Mice KW - Cell Line KW - Macrophages -- cytology KW - Colon -- metabolism KW - Colon -- cytology KW - Chemokines -- biosynthesis KW - Macrophage Activation -- physiology KW - Leptin -- physiology KW - Genes, APC KW - Chemotaxis, Leukocyte -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68984431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Leptin+induces+an+Apc+genotype-associated+colon+epithelial+cell+chemokine+production+pattern+associated+with+macrophage+chemotaxis+and+activation.&rft.au=Fenton%2C+Jenifer+I%3BHursting%2C+Stephen+D%3BPerkins%2C+Susan+N%3BHord%2C+Norman+G&rft.aulast=Fenton&rft.aufirst=Jenifer&rft.date=2007-02-01&rft.volume=28&rft.issue=2&rft.spage=455&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-26 N1 - Date created - 2007-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A phase II study of second-line neoadjuvant chemotherapy with capecitabine and radiation therapy for anthracycline-resistant locally advanced breast cancer. AN - 68982754; 17278899 AB - According to data from Brazil's National Cancer Institute nearly 30% of the new patients who present with breast cancer have locally advanced disease. These patients are inoperable and tumor reduction is usually attempted with chemotherapy. First-line anthracyclin-based neoadjuvant chemotherapy is often effective; however, about 30% of the patients fail and to date there is no established second-line treatment. We have studied the concomitant use of radiation therapy and capecitabine in this setting, to determine the toxicity and efficacy of this regimen as a second-line neoadjuvant treatment. Twenty-eight patients with inoperable locally advanced breast cancer refractory to first-line anthracycline based treatment were enrolled between January 2003 and May 2004. Patients received radiation therapy (total dose 5000 cGy) and concomitant capecitabine (850 mg/m2) twice daily for 14 days every 3 weeks. This treatment rendered 23 of the 28 patients (82%) operable. The 5 remaining patients did not undergo surgery because of disease progression. The median clinical tumor size decreased from 80 cm2 to 49 cm2. Microscopic residual disease was observed in 3 patients (13%) and another patient achieved a complete pathologic response. The median number of involved lymph nodes was 2 and treatment was well tolerated with no grade 3 or 4 events. Our data indicate that second-line neoadjuvant treatment with radiation therapy and capecitabine is feasible, well tolerated, and effective in patients with locally advanced breast cancer refractory to primary anthracycline-based treatment. These results suggest that a randomized study should be done to compare radiotherapy alone to capecitabine combined with radiotherapy. JF - American journal of clinical oncology AU - Gaui, Maria de Fátima Dias AU - Amorim, Gilberto AU - Arcuri, Roberto Alfonso AU - Pereira, Guilherme AU - Moreira, Denise AU - Djahjah, Célia AU - Biasoli, Irene AU - Spector, Nelson AD - Oncology and Pathology Services, National Cancer Institute, Rio de Janeiro, Brazil. mfgaui@hotmail.com Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 78 EP - 81 VL - 30 IS - 1 KW - Anthracyclines KW - 0 KW - Antimetabolites, Antineoplastic KW - Receptors, Estrogen KW - Receptors, Progesterone KW - Deoxycytidine KW - 0W860991D6 KW - Capecitabine KW - 6804DJ8Z9U KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Combined Modality Therapy -- methods KW - Neoplasm Invasiveness KW - Anthracyclines -- therapeutic use KW - Neoplasm Staging KW - Humans KW - Aged KW - Receptors, Estrogen -- analysis KW - Drug Resistance, Neoplasm KW - Receptors, Progesterone -- analysis KW - Adult KW - Middle Aged KW - Lymph Node Excision KW - Chemotherapy, Adjuvant KW - Female KW - Fluorouracil -- therapeutic use KW - Breast Neoplasms -- drug therapy KW - Deoxycytidine -- toxicity KW - Breast Neoplasms -- pathology KW - Fluorouracil -- toxicity KW - Deoxycytidine -- analogs & derivatives KW - Fluorouracil -- analogs & derivatives KW - Antimetabolites, Antineoplastic -- toxicity KW - Deoxycytidine -- therapeutic use KW - Breast Neoplasms -- surgery KW - Breast Neoplasms -- radiotherapy KW - Antimetabolites, Antineoplastic -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68982754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+clinical+oncology&rft.atitle=A+phase+II+study+of+second-line+neoadjuvant+chemotherapy+with+capecitabine+and+radiation+therapy+for+anthracycline-resistant+locally+advanced+breast+cancer.&rft.au=Gaui%2C+Maria+de+F%C3%A1tima+Dias%3BAmorim%2C+Gilberto%3BArcuri%2C+Roberto+Alfonso%3BPereira%2C+Guilherme%3BMoreira%2C+Denise%3BDjahjah%2C+C%C3%A9lia%3BBiasoli%2C+Irene%3BSpector%2C+Nelson&rft.aulast=Gaui&rft.aufirst=Maria+de+F%C3%A1tima&rft.date=2007-02-01&rft.volume=30&rft.issue=1&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=American+journal+of+clinical+oncology&rft.issn=1537-453X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-26 N1 - Date created - 2007-02-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Am J Clin Oncol. 2007 Jun;30(3):331 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lead promotes abasic site accumulation and co-mutagenesis in mammalian cells by inhibiting the major abasic endonuclease Ape1. AN - 68980678; 17013835 AB - Lead is a widespread environmental toxin, found in contaminated water sources, household paints, and certain occupational settings. Classified as a probable carcinogen by the International Agency for Research on Cancer (IARC), lead promotes mutagenesis when combined with alkylating and oxidizing DNA-damaging agents. We previously reported that lead inhibits the in vitro repair activity of Ape1, the major endonuclease for repairing mutagenic and cytotoxic abasic sites in DNA. We investigated here whether lead targets Ape1 in cultured mammalian cells. We report a concentration-dependent inhibition of apurinic/apyrimidinic (AP) site incision activity of Chinese hamster ovary (CHO) AA8 whole cell extracts by lead. In addition, lead exposure results in a concentration-dependent accumulation of AP sites in the genomic DNA of AA8 cells. An increase in the oxidative base lesion 8-oxoguanine was observed only at high lead levels (500 microM), suggesting that non-specific oxidation plays little role in the production of lead-related AP lesions at physiological metal concentrations--a conclusion corroborated by "thiobarbituric acid reactive substances" assays. Notably, Ape1 overexpression in AA8 (hApe1-3 cell line) abrogated the lead-dependent increase in AP site steady-state levels. Moreover, lead functioned cooperatively to promote a further increase in abasic sites with agents known to generate AP sites in DNA (i.e., methyl methansulfonate (MMS) and hydrogen peroxide (H2O2), but not the DNA crosslinking agent mitomycin C. Hypoxanthine guanine phosphoribosyltransferase (hprt) mutation analysis revealed that, whereas lead alone had no effect on mutation frequencies, mutagenesis increased in MMS treated, and to a greater extent lead/MMS treated, AA8 cells. With the hApe1-3 cell line, the number of mutant colonies in all treatment groups was found to be equal to that of the background level, indicating that Ape1 overexpression reverses MMS- and lead-associated hprt mutagenesis. Our studies in total indicate that Ape1 is a member of an emerging group of DNA surveillance proteins that are inhibited by environmental heavy metals, and suggest an underlying mechanism by which lead promotes co-carcinogenesis. JF - Molecular carcinogenesis AU - McNeill, Daniel R AU - Wong, Heng-Kuan AU - Narayana, Avinash AU - Wilson, David M AD - Laboratory of Molecular Gerontology, GRC, National Institute on Aging, IRP, NIH, Baltimore, Maryland 21224-6825, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 91 EP - 99 VL - 46 IS - 2 SN - 0899-1987, 0899-1987 KW - Mutagens KW - 0 KW - Thiobarbituric Acid Reactive Substances KW - Lead KW - 2P299V784P KW - Hypoxanthine Phosphoribosyltransferase KW - EC 2.4.2.8 KW - APEX1 protein, human KW - EC 4.2.99.18 KW - DNA-(Apurinic or Apyrimidinic Site) Lyase KW - Index Medicus KW - Thiobarbituric Acid Reactive Substances -- metabolism KW - Animals KW - Hypoxanthine Phosphoribosyltransferase -- genetics KW - Cricetulus KW - DNA Damage KW - Mutagens -- toxicity KW - CHO Cells KW - Cell Line KW - Mutagenesis KW - Cricetinae KW - DNA-(Apurinic or Apyrimidinic Site) Lyase -- antagonists & inhibitors KW - Lead -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68980678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Lead+promotes+abasic+site+accumulation+and+co-mutagenesis+in+mammalian+cells+by+inhibiting+the+major+abasic+endonuclease+Ape1.&rft.au=McNeill%2C+Daniel+R%3BWong%2C+Heng-Kuan%3BNarayana%2C+Avinash%3BWilson%2C+David+M&rft.aulast=McNeill&rft.aufirst=Daniel&rft.date=2007-02-01&rft.volume=46&rft.issue=2&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=08991987&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-26 N1 - Date created - 2007-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prepubertal gynecomastia linked to lavender and tea tree oils. AN - 68975271; 17267908 AB - Most cases of male prepubertal gynecomastia are classified as idiopathic. We investigated possible causes of gynecomastia in three prepubertal boys who were otherwise healthy and had normal serum concentrations of endogenous steroids. In all three boys, gynecomastia coincided with the topical application of products that contained lavender and tea tree oils. Gynecomastia resolved in each patient shortly after the use of products containing these oils was discontinued. Furthermore, studies in human cell lines indicated that the two oils had estrogenic and antiandrogenic activities. We conclude that repeated topical exposure to lavender and tea tree oils probably caused prepubertal gynecomastia in these boys. 2007 Massachusetts Medical Society JF - The New England journal of medicine AU - Henley, Derek V AU - Lipson, Natasha AU - Korach, Kenneth S AU - Bloch, Clifford A AD - Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 479 EP - 485 VL - 356 IS - 5 KW - Androgen Antagonists KW - 0 KW - IGFBP3 protein, human KW - Insulin-Like Growth Factor Binding Protein 3 KW - Insulin-Like Growth Factor Binding Proteins KW - Oils, Volatile KW - Plant Oils KW - RNA, Messenger KW - Receptors, Estrogen KW - Tea Tree Oil KW - 68647-73-4 KW - Cathepsin D KW - EC 3.4.23.5 KW - lavender oil KW - ZBP1YXW0H8 KW - Abridged Index Medicus KW - Index Medicus KW - Cathepsin D -- genetics KW - Receptors, Estrogen -- drug effects KW - Dose-Response Relationship, Drug KW - Humans KW - Breast Neoplasms KW - Cells, Cultured -- drug effects KW - Child KW - Insulin-Like Growth Factor Binding Proteins -- genetics KW - Cathepsin D -- biosynthesis KW - Insulin-Like Growth Factor Binding Proteins -- biosynthesis KW - RNA, Messenger -- biosynthesis KW - Child, Preschool KW - Genes, myc -- drug effects KW - Male KW - Androgen Antagonists -- pharmacology KW - Oils, Volatile -- pharmacology KW - Oils, Volatile -- adverse effects KW - Tea Tree Oil -- adverse effects KW - Plant Oils -- pharmacology KW - Plant Oils -- adverse effects KW - Gynecomastia -- chemically induced KW - Tea Tree Oil -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68975271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Prepubertal+gynecomastia+linked+to+lavender+and+tea+tree+oils.&rft.au=Henley%2C+Derek+V%3BLipson%2C+Natasha%3BKorach%2C+Kenneth+S%3BBloch%2C+Clifford+A&rft.aulast=Henley&rft.aufirst=Derek&rft.date=2007-02-01&rft.volume=356&rft.issue=5&rft.spage=479&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-20 N1 - Date created - 2007-02-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Reprod Toxicol. 2014 Apr;44:50-1 [24556344] N Engl J Med. 2007 Jun 14;356(24):2541-2; author reply 2543-4 [17568039] N Engl J Med. 2007 Jun 14;356(24):2543; author reply 2543-4 [17575591] N Engl J Med. 2007 Jun 14;356(24):2542-3; author reply 2543-4 [17575593] N Engl J Med. 2007 Jun 14;356(24):2542; author reply 2543-4 [17575592] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fatal leukoencephalopathy after reduced-intensity allogeneic stem cell transplantation. AN - 68962384; 17264526 AB - Toxicity associated with immunosuppression and conditioning regimens represents a common cause of neurological complications after allogeneic stem cell transplantation. We present a 56-year-old female patient with refractory acute lymphoblastic leukemia undergoing reduced-intensity conditioning with fludarabine, BCNU and melphalan followed by matched-sibling allogeneic stem cell transplantation. Under immunosuppressive treatment with cyclosporine A (CSA) the patient developed early-onset (day +33) and ultimately fatal leukoencephalopathy. As fludarabine and CSA represent two key substances of today's reduced-intensity conditioning regimens we raise the question of whether CSA, fludarabine or a combination of both led to this outcome and discuss differential diagnoses. JF - Onkologie AU - Mielke, Stephan AU - Potthoff, Karin AU - Feuerhake, Friedrich AU - Bley, Thorsten A AU - Windfuhr, Marisa AU - Bertz, Hartmut AU - Finke, Jürgen AD - Department of Hematology and Oncology, University of Freiburg Medical Center, Freiburg i. Br., Germany. mielkes@nhlbi.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 49 EP - 52 VL - 30 IS - 1-2 SN - 0378-584X, 0378-584X KW - Antineoplastic Agents KW - 0 KW - Immunosuppressive Agents KW - Cyclosporine KW - 83HN0GTJ6D KW - Vidarabine KW - FA2DM6879K KW - fludarabine KW - P2K93U8740 KW - Melphalan KW - Q41OR9510P KW - Carmustine KW - U68WG3173Y KW - Index Medicus KW - Fatal Outcome KW - Combined Modality Therapy KW - Humans KW - Risk Assessment KW - Melphalan -- administration & dosage KW - Melphalan -- adverse effects KW - Middle Aged KW - Carmustine -- adverse effects KW - Stem Cell Transplantation KW - Carmustine -- administration & dosage KW - Female KW - Immunosuppressive Agents -- administration & dosage KW - Immunosuppressive Agents -- adverse effects KW - Vidarabine -- analogs & derivatives KW - Cyclosporine -- administration & dosage KW - Cyclosporine -- adverse effects KW - Demyelinating Diseases -- diagnosis KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- surgery KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Vidarabine -- administration & dosage KW - Vidarabine -- adverse effects KW - Demyelinating Diseases -- chemically induced KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68962384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Onkologie&rft.atitle=Fatal+leukoencephalopathy+after+reduced-intensity+allogeneic+stem+cell+transplantation.&rft.au=Mielke%2C+Stephan%3BPotthoff%2C+Karin%3BFeuerhake%2C+Friedrich%3BBley%2C+Thorsten+A%3BWindfuhr%2C+Marisa%3BBertz%2C+Hartmut%3BFinke%2C+J%C3%BCrgen&rft.aulast=Mielke&rft.aufirst=Stephan&rft.date=2007-02-01&rft.volume=30&rft.issue=1-2&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Onkologie&rft.issn=0378584X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-20 N1 - Date created - 2007-01-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Molecular dissection and expression of the LdK39 kinesin in the human pathogen, Leishmania donovani. AN - 68961900; 17257310 AB - In this study we show for the first time the intracellular distribution of a K39 kinesin homologue in Leishmania donovani, a medically important parasite of humans. Further, we demonstrated that this motor protein is expressed in both the insect and mammalian developmental forms (i.e. promastigote and amastigotes) of this organism. Moreover, in both of these parasite developmental stages, immunofluorescence indicated that the LdK39 kinesin accumulated at anterior and posterior cell poles and that it displayed a peripheral localization consistent with the cortical cytoskeleton. Using a molecular approach, we identified, cloned and characterized the first complete open reading frame for the gene (LdK39) encoding this large (> 358 kDa) motor protein in L. donovani. Based on these observations, we subsequently used a homologous episomal expression system to dissect and express the functional domains that constitute the native molecule. Cell fractionation experiments demonstrated that LdK39 was soluble and that it bound to detergent-extracted cytoskeletons of these parasites in an ATP-dependent manner. The cumulative results of these experiments are consistent with LdK39 functioning as an ATP-dependent kinesin which binds to and travels along the cortical cytoskeleton of this important human pathogen. JF - Molecular microbiology AU - Gerald, Noel J AU - Coppens, Isabelle AU - Dwyer, Dennis M AD - Cell Biology Section, Laboratory of Parasitic Diseases, NIAID/NIH, Bethesda, MD, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 962 EP - 979 VL - 63 IS - 4 SN - 0950-382X, 0950-382X KW - Antigens, Protozoan KW - 0 KW - Detergents KW - Protozoan Proteins KW - Recombinant Fusion Proteins KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Sodium Azide KW - 968JJ8C9DV KW - Deoxyglucose KW - 9G2MP84A8W KW - K39 antigen, Leishmania KW - EC 3.6.1.- KW - Kinesin KW - EC 3.6.4.4 KW - Index Medicus KW - Phylogeny KW - Animals KW - Cytoskeleton -- metabolism KW - Deoxyglucose -- chemistry KW - Humans KW - Cloning, Molecular KW - Green Fluorescent Proteins -- genetics KW - Recombinant Fusion Proteins -- metabolism KW - Detergents -- chemistry KW - Sodium Azide -- chemistry KW - Cytoplasm -- metabolism KW - Adenosine Triphosphate -- metabolism KW - Recombinant Fusion Proteins -- genetics KW - Molecular Sequence Data KW - Protein Structure, Tertiary KW - Green Fluorescent Proteins -- metabolism KW - Protozoan Proteins -- metabolism KW - Antigens, Protozoan -- genetics KW - Protozoan Proteins -- genetics KW - Leishmania donovani -- chemistry KW - Kinesin -- genetics KW - Antigens, Protozoan -- metabolism KW - Kinesin -- metabolism KW - Leishmania donovani -- physiology KW - Leishmania donovani -- pathogenicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68961900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+microbiology&rft.atitle=Molecular+dissection+and+expression+of+the+LdK39+kinesin+in+the+human+pathogen%2C+Leishmania+donovani.&rft.au=Gerald%2C+Noel+J%3BCoppens%2C+Isabelle%3BDwyer%2C+Dennis+M&rft.aulast=Gerald&rft.aufirst=Noel&rft.date=2007-02-01&rft.volume=63&rft.issue=4&rft.spage=962&rft.isbn=&rft.btitle=&rft.title=Molecular+microbiology&rft.issn=0950382X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-06 N1 - Date created - 2007-01-31 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - DQ831678; GENBANK N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rapid identification of functionally critical amino acids in a G protein-coupled receptor. AN - 68959606; 17206152 AB - G protein-coupled receptors (GPCRs) comprise one of the largest protein families found in nature. Here we describe a new experimental strategy that allows rapid identification of functionally critical amino acids in the rat M(3) muscarinic acetylcholine receptor (M3R), a prototypic class I GPCR. This approach involves low-frequency random mutagenesis of the entire M3R coding sequence, followed by the application of a new yeast genetic screen that allows the recovery of inactivating M3R single point mutations. The vast majority of recovered mutant M3Rs also showed substantial functional impairments in transfected mammalian (COS-7) cells. A subset of mutant receptors, however, behaved differently in yeast and mammalian cells, probably because of the specific features of the yeast expression system used. The screening strategy described here should be applicable to all GPCRs that can be expressed functionally in yeast. JF - Nature methods AU - Li, Bo AU - Scarselli, Marco AU - Knudsen, Christopher D AU - Kim, Soo-Kyung AU - Jacobson, Kenneth A AU - McMillin, Sara M AU - Wess, Jürgen AD - Molecular Signaling, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 169 EP - 174 VL - 4 IS - 2 SN - 1548-7091, 1548-7091 KW - Amino Acids KW - 0 KW - Receptor, Muscarinic M3 KW - Index Medicus KW - Rats KW - Polymerase Chain Reaction KW - Animals KW - COS Cells KW - Cercopithecus aethiops KW - Point Mutation KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Saccharomyces cerevisiae KW - Mutagenesis KW - Amino Acids -- analysis KW - Receptor, Muscarinic M3 -- chemistry KW - Receptor, Muscarinic M3 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68959606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+methods&rft.atitle=Rapid+identification+of+functionally+critical+amino+acids+in+a+G+protein-coupled+receptor.&rft.au=Li%2C+Bo%3BScarselli%2C+Marco%3BKnudsen%2C+Christopher+D%3BKim%2C+Soo-Kyung%3BJacobson%2C+Kenneth+A%3BMcMillin%2C+Sara+M%3BWess%2C+J%C3%BCrgen&rft.aulast=Li&rft.aufirst=Bo&rft.date=2007-02-01&rft.volume=4&rft.issue=2&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Nature+methods&rft.issn=15487091&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-16 N1 - Date created - 2007-01-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy. AN - 68957584; 17125767 AB - Pyridoxine (vitamin B6) intoxicated rodents develop a peripheral neuropathy characterized by sensory nerve conduction deficits associated with disturbances of nerve fiber geometry and axonal atrophy. To investigate the possibility that glucagon-like peptide-1 (7-36)-amide (GLP-1) receptor agonism may influence axonal structure and function through neuroprotection neurotrophic support, effects of GLP-1 and its long acting analog, Exendin-4 (Ex4) treatment on pyridoxine-induced peripheral neuropathy were examined in rats using behavioral and morphometric techniques. GLP-1 is an endogenous insulinotropic peptide secreted from the gut in response to the presence of food. GLP-1 receptors (GLP-1R) are coupled to the cAMP second messenger pathway, and are expressed widely throughout neural tissues of humans and rodents. Recent studies have established that GLP-1 and Ex4, have multiple synergistic effects on glucose-dependent insulin secretion pathways of pancreatic beta-cells and on neural plasticity. Data reported here suggest that clinically relevant doses of GLP-1 and Ex4 may offer some protection against the sensory peripheral neuropathy induced by pyridoxine. Our findings suggest a potential role for these peptides in the treatment of neuropathies, including that associated with type II diabetes mellitus. JF - Experimental neurology AU - Perry, TracyAnn AU - Holloway, Harold W AU - Weerasuriya, Ananda AU - Mouton, Peter R AU - Duffy, Kara AU - Mattison, Julie A AU - Greig, Nigel H AD - Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Room 2C13, Gerontology Research Center, 5600 Nathan Shock Dr., Baltimore, MD 21224, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 293 EP - 301 VL - 203 IS - 2 SN - 0014-4886, 0014-4886 KW - Blood Glucose KW - 0 KW - GLP1R protein, human KW - Glp1r protein, rat KW - Glucagon-Like Peptide-1 Receptor KW - Neuroprotective Agents KW - Peptides KW - Receptors, Glucagon KW - Venoms KW - Vitamins KW - Glucagon-Like Peptide 1 KW - 89750-14-1 KW - exenatide KW - 9P1872D4OL KW - Pyridoxine KW - KV2JZ1BI6Z KW - Index Medicus KW - Animals KW - Muscle Tonus -- physiology KW - Blood Glucose -- metabolism KW - Nerve Degeneration -- chemically induced KW - Amino Acid Sequence KW - Postural Balance -- drug effects KW - Rats KW - Behavior, Animal -- drug effects KW - Rats, Sprague-Dawley KW - Ganglia, Spinal -- pathology KW - Body Weight -- drug effects KW - Nerve Degeneration -- pathology KW - Molecular Sequence Data KW - Sciatic Nerve -- pathology KW - Male KW - Receptors, Glucagon -- agonists KW - Venoms -- therapeutic use KW - Neurons, Afferent KW - Peripheral Nervous System Diseases -- prevention & control KW - Peripheral Nervous System Diseases -- chemically induced KW - Glucagon-Like Peptide 1 -- physiology KW - Peptides -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68957584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+neurology&rft.atitle=Evidence+of+GLP-1-mediated+neuroprotection+in+an+animal+model+of+pyridoxine-induced+peripheral+sensory+neuropathy.&rft.au=Perry%2C+TracyAnn%3BHolloway%2C+Harold+W%3BWeerasuriya%2C+Ananda%3BMouton%2C+Peter+R%3BDuffy%2C+Kara%3BMattison%2C+Julie+A%3BGreig%2C+Nigel+H&rft.aulast=Perry&rft.aufirst=TracyAnn&rft.date=2007-02-01&rft.volume=203&rft.issue=2&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Experimental+neurology&rft.issn=00144886&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-20 N1 - Date created - 2007-01-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Endocrinology. 2000 Apr;141(4):1301-9 [10746632] Curr Pharm Des. 2006;12(14):1731-50 [16712485] J Pharmacol Exp Ther. 2002 Sep;302(3):881-8 [12183643] J Neurosci Res. 2003 Jun 1;72(5):603-12 [12749025] Trends Pharmacol Sci. 2003 Jul;24(7):377-83 [12871671] Nat Med. 2003 Sep;9(9):1173-9 [12925848] Auton Neurosci. 2004 Jan 30;110(1):36-43 [14766323] Muscle Nerve. 2004 Sep;30(3):255-68 [15318336] Exp Neurol. 2004 Nov;190(1):133-44 [15473987] Agents Actions. 1982 Oct;12(4):575-82 [7180742] Neurology. 1985 Nov;35(11):1617-22 [2997659] Neurology. 1987 Nov;37(11):1729-32 [2823181] Toxicology. 1988 Apr;49(1):171-8 [3376123] Neurology. 1989 Aug;39(8):1077-83 [2761702] Nature. 1996 Jan 4;379(6560):69-72 [8538742] Eur J Neurosci. 1995 Nov 1;7(11):2294-300 [8563978] Endocrinology. 1996 Nov;137(11):5159-62 [8895391] J Clin Invest. 1997 Jun 15;99(12):2883-9 [9185511] Exp Gerontol. 1998 Sep;33(6):615-24 [9789738] Diabetologia. 1999 Jan;42(1):45-50 [10027577] Ann N Y Acad Sci. 2004 Dec;1035:290-315 [15681814] Curr Alzheimer Res. 2005 Jul;2(3):377-85 [15974903] Diabetologia. 2006 Feb;49(2):253-60 [16416146] J Clin Oncol. 2006 Apr 1;24(10):1633-42 [16575015] Curr Opin Investig Drugs. 2006 Apr;7(4):324-37 [16625819] J Pharmacol Exp Ther. 2002 Mar;300(3):958-66 [11861804] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sirolimus therapy of focal segmental glomerulosclerosis is associated with nephrotoxicity. AN - 68956789; 17261434 AB - To evaluate the safety and efficacy of sirolimus in treating patients with focal segmental glomerulosclerosis (FSGS), we performed a phase 2, open-label clinical trial. Inclusion criteria were adults and children 13 years and older with biopsy-proven idiopathic FSGS, proteinuria with protein of 3.5 g/d or greater while on angiotensin antagonist therapy, glomerular filtration rate (GFR) of 30 mL/min/1.73 m(2) or greater (>or=0.50 mL/s), and failure to achieve sustained remission with at least 1 immunosuppressive agent. Eligible patients received sirolimus doses adjusted to achieve trough levels of 5 to 15 ng/mL during the first 4 months and 10 to 20 ng/mL for the subsequent 8 months. The primary outcome was decrease in proteinuria, expressed as complete remission (protein or= 50% decrease and 18 mmol/L) at 5 months in 1 patient. Because of a rapid decrease in GFR with worsening proteinuria, the protocol was closed to further recruitment. We conclude that sirolimus may be associated with nephrotoxicity in some patients with FSGS, particularly those with prolonged disease duration and prior cyclosporine therapy. JF - American journal of kidney diseases : the official journal of the National Kidney Foundation AU - Cho, Monique E AU - Hurley, John K AU - Kopp, Jeffrey B AD - Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-1268, USA. moniquec@intra.niddk.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 310 EP - 317 VL - 49 IS - 2 KW - Sirolimus KW - W36ZG6FT64 KW - Index Medicus KW - Proteinuria -- physiopathology KW - Glomerular Filtration Rate -- physiology KW - Humans KW - Proteinuria -- complications KW - In Vitro Techniques KW - Adult KW - Middle Aged KW - Male KW - Female KW - Proteinuria -- chemically induced KW - Sirolimus -- adverse effects KW - Kidney Diseases -- physiopathology KW - Glomerulosclerosis, Focal Segmental -- drug therapy KW - Glomerulosclerosis, Focal Segmental -- physiopathology KW - Kidney Diseases -- complications KW - Kidney Diseases -- chemically induced KW - Glomerulosclerosis, Focal Segmental -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68956789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.atitle=Sirolimus+therapy+of+focal+segmental+glomerulosclerosis+is+associated+with+nephrotoxicity.&rft.au=Cho%2C+Monique+E%3BHurley%2C+John+K%3BKopp%2C+Jeffrey+B&rft.aulast=Cho&rft.aufirst=Monique&rft.date=2007-02-01&rft.volume=49&rft.issue=2&rft.spage=310&rft.isbn=&rft.btitle=&rft.title=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.issn=1523-6838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-14 N1 - Date created - 2007-01-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tarantula toxins interacting with voltage sensors in potassium channels. AN - 68954836; 17097703 AB - Voltage-activated ion channels open and close in response to changes in membrane voltage, a process that is crucial for electrical signaling in the nervous system. The venom from many poisonous creatures contains a diverse array of small protein toxins that bind to voltage-activated channels and modify the gating mechanism. Hanatoxin and a growing number of related tarantula toxins have been shown to inhibit activation of voltage-activated potassium (K(v)) channels by interacting with their voltage-sensing domains. This review summarizes our current understanding of the mechanism by which these toxins alter gating, the location of the toxin receptor within K(v) channels and the disposition of this receptor with respect to the lipid membrane. The conservation of tarantula toxin receptors among voltage-activated ion channels will also be discussed. JF - Toxicon : official journal of the International Society on Toxinology AU - Swartz, Kenton J AD - Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. swartzk@ninds.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 213 EP - 230 VL - 49 IS - 2 SN - 0041-0101, 0041-0101 KW - Potassium Channels KW - 0 KW - Spider Venoms KW - Index Medicus KW - Animals KW - Sequence Alignment KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Ion Channel Gating -- physiology KW - Potassium Channels -- drug effects KW - Spider Venoms -- pharmacology KW - Spider Venoms -- genetics KW - Ion Channel Gating -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68954836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.atitle=Tarantula+toxins+interacting+with+voltage+sensors+in+potassium+channels.&rft.au=Swartz%2C+Kenton+J&rft.aulast=Swartz&rft.aufirst=Kenton&rft.date=2007-02-01&rft.volume=49&rft.issue=2&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.issn=00410101&rft_id=info:doi/ LA - 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Last updated - 2017-01-18 ER - TY - JOUR T1 - Alkylene tether-length dependent gamma-aminobutyric acid type A receptor competitive antagonism by tacrine dimers. AN - 68953568; 17056074 AB - Bis(7)-tacrine was previously demonstrated as an antagonist of gamma-aminobutyric acid type A (GABA(A)) receptors. In this study, the effects of a series of alkylene-linked tacrine dimers on GABA(A) receptors were examined. In radioligand binding assay, the analogues differed in binding affinity for GABA(A) receptors, and potency monotonically increased as the tether was shortened from nine to two methylenes. Bis(2)-tacrine, the shortest tacrine dimer, could displace [(3)H]muscimol from rat brain membranes with an IC(50) of 0.48 microM, which was 11, 13 and 525 times more potent than the GABA(A) receptor antagonist (+)-bicuculline, bis(7)-tacrine and tacrine, respectively. In whole-cell patch-clamp recordings, these dimeric tacrine analogues competitively antagonized GABA-induced inward current with a rank order of potency of bis(2)-tacrine>bicuculline>bis(7)-tacrine>bis(9)-tacrine>tacrine, and the potency of bis(2)-tacrine was 11, 18 and 487 times higher than that of (+)-bicuculline, bis(7)-tacrine and tacrine, respectively. Bis(2)-tacrine shifted the GABA concentration-response curve to the right in a parallel manner, and the inhibition was voltage-independent between -80 and +20 mV. It can be concluded that the shorter the alkylene linkage in tacrine dimers the stronger the binding affinity and higher the antagonistic effect on the GABA(A) receptor will be. JF - Neuropharmacology AU - Li, Chaoying AU - Carlier, Paul R AU - Ren, Hong AU - Kan, Kelvin K W AU - Hui, Kwokmin AU - Wang, Hong AU - Li, Wenming AU - Li, Zhiwang AU - Xiong, Keming AU - Clement, Ella Chow AU - Xue, Hong AU - Liu, Xiangou AU - Li, Mingtao AU - Pang, Yuanping AU - Han, Yifan AD - Laboratory of Molecular and Cellular Neurobiology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 436 EP - 443 VL - 52 IS - 2 SN - 0028-3908, 0028-3908 KW - GABA Antagonists KW - 0 KW - GABA-A Receptor Antagonists KW - Tacrine KW - 4VX7YNB537 KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Bicuculline KW - Y37615DVKC KW - Index Medicus KW - Bicuculline -- pharmacology KW - Animals KW - Drug Interactions KW - Models, Molecular KW - Dose-Response Relationship, Drug KW - gamma-Aminobutyric Acid -- pharmacology KW - Neurons -- drug effects KW - Dimerization KW - Membrane Potentials -- physiology KW - Radioligand Assay KW - Dose-Response Relationship, Radiation KW - Electric Stimulation KW - GABA Antagonists -- pharmacology KW - Alkylation -- drug effects KW - Structure-Activity Relationship KW - Rats KW - Ganglia, Spinal -- cytology KW - Rats, Sprague-Dawley KW - Patch-Clamp Techniques KW - Neurons -- physiology KW - Membrane Potentials -- drug effects KW - Inhibitory Concentration 50 KW - Male KW - Tacrine -- chemistry KW - Tacrine -- pharmacology KW - Tacrine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68953568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Alkylene+tether-length+dependent+gamma-aminobutyric+acid+type+A+receptor+competitive+antagonism+by+tacrine+dimers.&rft.au=Li%2C+Chaoying%3BCarlier%2C+Paul+R%3BRen%2C+Hong%3BKan%2C+Kelvin+K+W%3BHui%2C+Kwokmin%3BWang%2C+Hong%3BLi%2C+Wenming%3BLi%2C+Zhiwang%3BXiong%2C+Keming%3BClement%2C+Ella+Chow%3BXue%2C+Hong%3BLiu%2C+Xiangou%3BLi%2C+Mingtao%3BPang%2C+Yuanping%3BHan%2C+Yifan&rft.aulast=Li&rft.aufirst=Chaoying&rft.date=2007-02-01&rft.volume=52&rft.issue=2&rft.spage=436&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-10 N1 - Date created - 2007-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tamoxifen effect on L-DOPA induced response complications in parkinsonian rats and primates. AN - 68953269; 17116309 AB - The contribution of striatal protein kinase C (PKC) isoform changes in levodopa (L-DOPA) induced motor response complications in parkinsonian rats was investigated and the ability of tamoxifen, an antiestrogen with a partial PKC antagonist property, to prevent these response alterations in 6-hydroxydopamine (6-OHDA) lesioned rats as well as in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treated cynomologous monkeys was studied. Following treatment of adult male rats with L-DOPA twice daily for 3 weeks, protein levels of left (lesioned) and right (intact) striatal PKC isoforms were measured. Western blot analysis showed increased protein expression of both the novel PKC epsilon isoform and the atypical PKC lambda isoform ipsilateral to the lesion (174+/-17% for epsilon, 140+/-9% for lambda, of intact striatum in 6-OHDA lesioned plus chronic L-DOPA treated animals) in acute L-DOPA treated rats. No enhancement was observed in PKC immunoreactivity for other isoforms. Tamoxifen (5.0 mg/kg p.o.) significantly attenuated the L-DOPA induced augmentation of protein expression of PKC epsilon and PKC lambda, but had no effect on immunoreactivity for other PKC isoforms. In chronic L-DOPA treated parkinsonian rats, tamoxifen prevented (5.0 mg/kg p.o.) as well as ameliorated (5.0 mg/kg p.o.) the characteristic shortening in duration of motor response to L-DOPA challenge. In MPTP lesioned primates, similar to the ameliorative effect seen in rats, tamoxifen (1 and 3 mg/kg p.o) reduced the appearance of L-DOPA induced dyskinesia by 61% and 55% respectively (p<0.05). These results suggest that changes in specific striatal PKC isoforms contribute to the pathogenesis of L-DOPA induced motor complications and further that drugs able to selectively inhibit these signaling kinases might provide adjunctive benefit in the treatment of Parkinson's disease. JF - Neuropharmacology AU - Smith, C P S AU - Oh, J D AU - Bibbiani, F AU - Collins, M A AU - Avila, I AU - Chase, T N AD - Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 515 EP - 526 VL - 52 IS - 2 SN - 0028-3908, 0028-3908 KW - Antiparkinson Agents KW - 0 KW - Nerve Tissue Proteins KW - Selective Estrogen Receptor Modulators KW - Tamoxifen KW - 094ZI81Y45 KW - Levodopa KW - 46627O600J KW - Oxidopamine KW - 8HW4YBZ748 KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine KW - 9P21XSP91P KW - Protein Kinase C KW - EC 2.7.11.13 KW - Index Medicus KW - Animals KW - Parkinson Disease, Secondary -- chemically induced KW - Drug Administration Schedule KW - Drug Interactions KW - Disease Models, Animal KW - Models, Biological KW - Haplorhini KW - Parkinson Disease, Secondary -- drug therapy KW - Rats KW - Protein Kinase C -- metabolism KW - Rats, Sprague-Dawley KW - Nerve Tissue Proteins -- metabolism KW - Time Factors KW - Male KW - Antiparkinson Agents -- adverse effects KW - Dyskinesia, Drug-Induced -- drug therapy KW - Tamoxifen -- therapeutic use KW - Selective Estrogen Receptor Modulators -- therapeutic use KW - Dyskinesia, Drug-Induced -- etiology KW - Levodopa -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68953269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Tamoxifen+effect+on+L-DOPA+induced+response+complications+in+parkinsonian+rats+and+primates.&rft.au=Smith%2C+C+P+S%3BOh%2C+J+D%3BBibbiani%2C+F%3BCollins%2C+M+A%3BAvila%2C+I%3BChase%2C+T+N&rft.aulast=Smith&rft.aufirst=C+P&rft.date=2007-02-01&rft.volume=52&rft.issue=2&rft.spage=515&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-10 N1 - Date created - 2007-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Assessment of subconjunctival and intrascleral drug delivery to the posterior segment using dynamic contrast-enhanced magnetic resonance imaging. AN - 68951332; 17251481 AB - Sustained-release intravitreal drug implants for posterior segment diseases are associated with significant complications. As an alternative, subconjunctival infusions of drug to the episclera of the back of the eye have been performed, but results in clinical trials for macular diseases showed mixed To improve understanding of transscleral drug delivery to the posterior segment, the distribution and clearance of gadolinium-diethylene-triamino-penta-acetic acid (Gd-DTPA) infused in the subconjunctival or intrascleral space was investigated by means of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). In anesthetized rabbits, catheters were placed anteriorly in the subconjunctival or intrascleral space and infused with Gd-DTPA at 1 and 10 muL/min. Distribution and clearance of Gd-DTPA were measured using DCE-MRI. Histologic examination was performed to assess ocular toxicity of the delivery system. results. Subconjunctival infusions failed to produce detectable levels of Gd-DTPA in the back of the eye. In contrast, intrascleral infusions expanded the suprachoroidal layer and delivered Gd-DTPA to the posterior segment. Suprachoroidal clearance of Gd-DTPA followed first-order kinetics with an average half-life of 5.4 and 11.8 minutes after intrascleral infusions at 1 and 10 muL/min, respectively. Histologic examination demonstrated expansion of the tissues in the suprachoroidal space that normalized after infusion termination. An intrascleral infusion was successful in transporting Gd-DTPA to the posterior segment from an anterior infusion site with limited anterior segment exposure. The suprachoroidal space appears to be an expandible conduit for drug transport to the posterior segment. Further studies are indicated to explore the feasibility of clinical applications. JF - Investigative ophthalmology & visual science AU - Kim, Stephanie H AU - Galbán, Craig J AU - Lutz, Robert J AU - Dedrick, Robert L AU - Csaky, Karl G AU - Lizak, Martin J AU - Wang, Nam Sun AU - Tansey, Ginger AU - Robinson, Michael R AD - Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland, USA. kimstep@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 808 EP - 814 VL - 48 IS - 2 SN - 0146-0404, 0146-0404 KW - Contrast Media KW - 0 KW - Gadolinium DTPA KW - K2I13DR72L KW - Index Medicus KW - Animals KW - Magnetic Resonance Imaging -- methods KW - Rabbits KW - Infusions, Parenteral KW - Female KW - Retina -- metabolism KW - Drug Delivery Systems KW - Gadolinium DTPA -- pharmacokinetics KW - Contrast Media -- pharmacokinetics KW - Sclera -- drug effects KW - Choroid -- metabolism KW - Gadolinium DTPA -- administration & dosage KW - Contrast Media -- administration & dosage KW - Conjunctiva -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68951332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=Assessment+of+subconjunctival+and+intrascleral+drug+delivery+to+the+posterior+segment+using+dynamic+contrast-enhanced+magnetic+resonance+imaging.&rft.au=Kim%2C+Stephanie+H%3BGalb%C3%A1n%2C+Craig+J%3BLutz%2C+Robert+J%3BDedrick%2C+Robert+L%3BCsaky%2C+Karl+G%3BLizak%2C+Martin+J%3BWang%2C+Nam+Sun%3BTansey%2C+Ginger%3BRobinson%2C+Michael+R&rft.aulast=Kim&rft.aufirst=Stephanie&rft.date=2007-02-01&rft.volume=48&rft.issue=2&rft.spage=808&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=01460404&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-01 N1 - Date created - 2007-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nutritional interactions: credentialing of molecular targets for cancer prevention. AN - 68949566; 17259324 AB - Dietary behavior has been identified as one of the most important modifiable determinants of cancer risk. Which personalized modifications are needed remains an area of considerable controversy. Part of this uncertainty may arise from interactions among dietary bioactive compounds and/or food combinations. These interactions may either enhance or negate the response to specific foods. Evidence suggests that the cancer-protective effects of an individual's diet may reflect the combined effects of various vitamins, minerals, and other bioactive components such as flavonoids, isothiocyanates, and/or allium compounds rather than from the effect of a single ingredient. A better understanding of physiologically important interactions is needed to determine the merit of combining foods for maximum efficacy for cancer prevention. Furthermore, the response is complicated, since multiple cellular processes associated with carcinogenesis can be modified simultaneously, including sites such as drug metabolism, DNA repair, cell proliferation, apoptosis, inflammation, differentiation, and angiogenesis. Current evidence suggests that bioactive food components can typically influence more than one process. It is essential to have a better understanding of how the response relates to exposures and credentialing which process is most involved in bringing about a change in tumor incidence and/or tumor behavior. Credentialing is being defined as a determination of which cellular process(es) and which bioactive food components are most important for bringing about a phenotypic change. Additional attention is needed to determine the critical intake of dietary components, their duration, and when they should be provided to optimize the desired physiological response. Further research is also needed on the molecular targets for bioactive components and whether genetic and epigenetic events dictate the direction and magnitude of the response. JF - Experimental biology and medicine (Maywood, N.J.) AU - Davis, Cindy D AD - Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Boulevard, Suite 3159, Rockville, MD 20892-7328, USA. davisci@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 176 EP - 183 VL - 232 IS - 2 SN - 1535-3702, 1535-3702 KW - Index Medicus KW - Humans KW - Neoplasms -- pathology KW - Neoplasms -- prevention & control KW - Diet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68949566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+biology+and+medicine+%28Maywood%2C+N.J.%29&rft.atitle=Nutritional+interactions%3A+credentialing+of+molecular+targets+for+cancer+prevention.&rft.au=Davis%2C+Cindy+D&rft.aulast=Davis&rft.aufirst=Cindy&rft.date=2007-02-01&rft.volume=232&rft.issue=2&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=Experimental+biology+and+medicine+%28Maywood%2C+N.J.%29&rft.issn=15353702&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-22 N1 - Date created - 2007-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regulation of human skin pigmentation and responses to ultraviolet radiation. AN - 68944222; 17250543 AB - Pigmentation of human skin is closely involved in protection against environmental stresses, in particular exposure to ultraviolet (UV) radiation. It is well known that darker skin is significantly more resistant to the damaging effects of UV, such as photocarcinogenesis and photoaging, than is lighter skin. Constitutive skin pigmentation depends on the amount of melanin and its distribution in that tissue. Melanin is significantly photoprotective and epidermal cells in darker skin incur less DNA damage than do those in lighter skin. This review summarizes current understanding of the regulation of constitutive human skin pigmentation and responses to UV radiation, with emphasis on physiological factors that influence those processes. Further research is needed to characterize the role of skin pigmentation to reduce photocarcinogenesis and to develop effective strategies to minimize such risks. JF - Pigment cell research AU - Miyamura, Yoshinori AU - Coelho, Sergio G AU - Wolber, Rainer AU - Miller, Sharon A AU - Wakamatsu, Kazumasa AU - Zmudzka, Barbara Z AU - Ito, Shosuke AU - Smuda, Christoph AU - Passeron, Thierry AU - Choi, Wonseon AU - Batzer, Jan AU - Yamaguchi, Yuji AU - Beer, Janusz Z AU - Hearing, Vincent J AD - Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 2 EP - 13 VL - 20 IS - 1 SN - 0893-5785, 0893-5785 KW - Index Medicus KW - Skin -- radiation effects KW - Radiation Protection KW - Aging -- radiation effects KW - Humans KW - Skin -- cytology KW - Melanocytes -- cytology KW - Melanocytes -- radiation effects KW - Ultraviolet Rays KW - Skin Pigmentation -- radiation effects KW - Skin Pigmentation -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68944222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pigment+cell+research&rft.atitle=Regulation+of+human+skin+pigmentation+and+responses+to+ultraviolet+radiation.&rft.au=Miyamura%2C+Yoshinori%3BCoelho%2C+Sergio+G%3BWolber%2C+Rainer%3BMiller%2C+Sharon+A%3BWakamatsu%2C+Kazumasa%3BZmudzka%2C+Barbara+Z%3BIto%2C+Shosuke%3BSmuda%2C+Christoph%3BPasseron%2C+Thierry%3BChoi%2C+Wonseon%3BBatzer%2C+Jan%3BYamaguchi%2C+Yuji%3BBeer%2C+Janusz+Z%3BHearing%2C+Vincent+J&rft.aulast=Miyamura&rft.aufirst=Yoshinori&rft.date=2007-02-01&rft.volume=20&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Pigment+cell+research&rft.issn=08935785&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-19 N1 - Date created - 2007-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Induction of the formyl peptide receptor 2 in microglia by IFN-gamma and synergy with CD40 ligand. AN - 68939925; 17237425 AB - Human formyl peptide receptor (FPR)-like 1 (FPRL1) and its mouse homologue mFPR2 are functional receptors for a variety of exogenous and host-derived chemotactic peptides, including amyloid beta 1-42 (Abeta(42)), a pathogenic factor in Alzheimer's disease. Because mFPR2 in microglial cells is regulated by proinflammatory stimulants including TLR agonists, in this study we investigated the capacity of IFN-gamma and the CD40 ligand (CD40L) to affect the expression and function of mFPR2. We found that IFN-gamma, when used alone, induced mFPR2 mRNA expression in a mouse microglial cell line and primary microglial cells in association with increased cell migration in response to mFPR2 agonists, including Abeta(42). IFN-gamma also increased the endocytosis of Abeta(42) by microglial cells via mFPR2. The effect of IFN-gamma on mFPR2 expression in microglial cells was dependent on activation of MAPK and IkappaB-alpha. IFN-gamma additionally increased the expression of CD40 by microglial cells and soluble CD40L significantly promoted cell responses to IFN-gamma during a 6-h incubation period by enhancing the activation of MAPK and IkappaB-alpha signaling pathways. We additionally found that the effect of IFN-gamma and its synergy with CD40L on mFPR2 expression in microglia was mediated in part by TNF-alpha. Our results suggest that IFN-gamma and CD40L, two host-derived factors with increased concentrations in inflammatory central nervous system diseases, may profoundly affect microglial cell responses in the pathogenic process in which mFPR2 agonist peptides are elevated. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Chen, Keqiang AU - Iribarren, Pablo AU - Huang, Jian AU - Zhang, Lingzhi AU - Gong, Wanghua AU - Cho, Edward H AU - Lockett, Stephen AU - Dunlop, Nancy M AU - Wang, Ji Ming AD - Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702, USA. Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 1759 EP - 1766 VL - 178 IS - 3 SN - 0022-1767, 0022-1767 KW - RNA, Messenger KW - 0 KW - Receptors, Formyl Peptide KW - Tumor Necrosis Factor-alpha KW - formyl peptide receptor 2, mouse KW - CD40 Ligand KW - 147205-72-9 KW - Interferon-gamma KW - 82115-62-6 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Tumor Necrosis Factor-alpha -- pharmacology KW - RNA, Messenger -- drug effects KW - Cell Movement -- drug effects KW - Mice KW - Drug Synergism KW - Signal Transduction KW - Microglia -- cytology KW - Interferon-gamma -- pharmacology KW - Gene Expression Regulation -- drug effects KW - Receptors, Formyl Peptide -- genetics KW - Microglia -- metabolism KW - CD40 Ligand -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68939925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Induction+of+the+formyl+peptide+receptor+2+in+microglia+by+IFN-gamma+and+synergy+with+CD40+ligand.&rft.au=Chen%2C+Keqiang%3BIribarren%2C+Pablo%3BHuang%2C+Jian%3BZhang%2C+Lingzhi%3BGong%2C+Wanghua%3BCho%2C+Edward+H%3BLockett%2C+Stephen%3BDunlop%2C+Nancy+M%3BWang%2C+Ji+Ming&rft.aulast=Chen&rft.aufirst=Keqiang&rft.date=2007-02-01&rft.volume=178&rft.issue=3&rft.spage=1759&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-27 N1 - Date created - 2007-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Receiver operating characteristic curve inference from a sample with a limit of detection. AN - 68934927; 17110640 AB - The receiver operating characteristic curve is a commonly used tool for evaluating biomarker usefulness in clinical diagnosis of disease. Frequently, biomarkers being assessed have immeasurable or unreportable samples below some limit of detection. Ignoring observations below the limit of detection leads to negatively biased estimates of the area under the curve. Several correction methods are suggested in the areas of mean estimation and testing but nothing regarding the receiver operating characteristic curve or its summary measures. In this paper, the authors show that replacement values below the limit of detection, including those suggested, result in the same biased area under the curve when properly accounted for, but they also provide guidance on the usefulness of these values in limited situations. The authors demonstrate maximum likelihood techniques leading to asymptotically unbiased estimators of the area under the curve for both normally and gamma distributed biomarker levels. Confidence intervals are proposed, the coverage probability of which is scrutinized by simulation study. An example using polychlorinated biphenyl levels to classify women with and without endometriosis illustrates the potential benefits of these methods. JF - American journal of epidemiology AU - Perkins, Neil J AU - Schisterman, Enrique F AU - Vexler, Albert AD - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 325 EP - 333 VL - 165 IS - 3 SN - 0002-9262, 0002-9262 KW - Biomarkers KW - 0 KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Sensitivity and Specificity KW - Endometriosis -- classification KW - Endometriosis -- chemically induced KW - Polychlorinated Biphenyls -- toxicity KW - Humans KW - Polychlorinated Biphenyls -- blood KW - Case-Control Studies KW - Likelihood Functions KW - Female KW - ROC Curve KW - Biomarkers -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68934927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Receiver+operating+characteristic+curve+inference+from+a+sample+with+a+limit+of+detection.&rft.au=Perkins%2C+Neil+J%3BSchisterman%2C+Enrique+F%3BVexler%2C+Albert&rft.aulast=Perkins&rft.aufirst=Neil&rft.date=2007-02-01&rft.volume=165&rft.issue=3&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-16 N1 - Date created - 2007-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Agreement between contemporaneously recorded and subsequently recalled time spent outdoors: implications for environmental exposure studies. AN - 68934682; 16882464 AB - The aim of the study is to evaluate the agreement between contemporaneously recorded and subsequently recalled time spent outdoors during 1 week among members of an occupational cohort. One hundred twenty-five radiologic technologists from northern and southern geographic areas in the United States recorded time spent outdoors for 7 consecutive days in a daily diary. Six months later, study participants completed a mailed self-administered questionnaire of the number of outdoor hours during the same 7-day period. We tested the agreement between questionnaire responses and diary entries. Logistic regression models were used to identify variables significantly affecting agreement. Time spent outdoors comprised one fifth of the total time recorded in the diaries. Agreement (weighted kappa [kappa(w)]) between reported outdoor time during weekdays (kappa(w) = 0.49; 95% confidence interval [CI], 0.39-0.59) was significantly (p < 0.05) higher than for weekends (kappa(w) = 0.23; 95% CI, 0.12-0.34). Similarly, agreement was lower for weekends compared with weekdays in multivariate analyses, reaching statistical significance (p = 0.05) in only the southern regions. Although our investigation was carried out among volunteers from the US radiologic technologist cohort, we believe retrospective questionnaires may be more accurate in reporting time spent outdoors for weekdays compared with weekends in any group of indoor workers. These differences have implications for the wording in future questionnaires about time spent outdoors and level and sources of uncertainty characterizing estimated time spent outdoors on weekdays versus weekend days. JF - Annals of epidemiology AU - Chodick, Gabriel AU - Freedman, Michal D AU - Kwok, Richard K AU - Fears, Thomas R AU - Linet, Martha S AU - Alexander, Bruce H AU - Kleinerman, Ruth A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health/DHHS, 6120 Executive Boulevard, Rockville, MD 20852, USA. chodick@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 106 EP - 111 VL - 17 IS - 2 SN - 1047-2797, 1047-2797 KW - Index Medicus KW - Minnesota KW - Humans KW - North Carolina KW - Adult KW - Surveys and Questionnaires KW - Retrospective Studies KW - Middle Aged KW - Georgia KW - Male KW - Female KW - Leisure Activities KW - Environmental Exposure KW - Sunlight KW - Mental Recall UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68934682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+epidemiology&rft.atitle=Agreement+between+contemporaneously+recorded+and+subsequently+recalled+time+spent+outdoors%3A+implications+for+environmental+exposure+studies.&rft.au=Chodick%2C+Gabriel%3BFreedman%2C+Michal+D%3BKwok%2C+Richard+K%3BFears%2C+Thomas+R%3BLinet%2C+Martha+S%3BAlexander%2C+Bruce+H%3BKleinerman%2C+Ruth+A&rft.aulast=Chodick&rft.aufirst=Gabriel&rft.date=2007-02-01&rft.volume=17&rft.issue=2&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Annals+of+epidemiology&rft.issn=10472797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-16 N1 - Date created - 2007-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Distribution of the 5-HT(1A) receptor antagonist [ (18)F]FPWAY in blood and brain of the rat with and without isoflurane anesthesia. AN - 68934215; 17021813 AB - To determine whether brain and plasma equilibrium of a proposed PET tracer for 5-HT(1A), [(18)F]FPWAY, can be achieved in a sufficiently short time for practical use of the brain to plasma equilibrium distribution ratio (DR) to monitor receptor availability with and without isoflurane anesthesia. Awake (n=4) and isoflurane-anesthetized (n=4) rats were administered a continuous 60 min intravenous infusion of [(18)F]FPWAY with timed arterial blood sampling. Brains of the isoflurane-anesthetized rats were scanned with the ATLAS small animal PET scanner; awake rats were not. All rats were killed at 60 min and scanned postmortem for 15 min, followed by brain slicing for autoradiography. Several regions of interest (ROIs) were defined in the PET images as well as in the autoradiographic images. Regional DRs were calculated as total activity in the brain ROI divided by plasma [(18)F]FPWAY activity. DRs in the anesthetized animals were constant between 30 and 60 min, indicating that near equilibrium between brain and plasma had been achieved by approximately 30 min. DRs determined from postmortem PET data were higher in the isoflurane-anesthetized rats by 24% (not significant) and 33% (p=0.065) in whole brain and hippocampus, respectively. DRs determined from autoradiographic data were greater in isoflurane-anesthetized rats in medial hippocampus, lateral hippocampus, and cerebellum by 33% (p=0.054), 63% (p<0.01), and 32% (p<0.05), respectively. [(18)F]FPWAY could be an appropriate ligand for monitoring changes in receptor availability in the serotonergic system using a bolus/infusion paradigm. One possible explanation for higher DRs in anesthetized rats may be a reduction in endogenous 5-HT secretion under isoflurane anesthesia. JF - European journal of nuclear medicine and molecular imaging AU - Tokugawa, Joji AU - Ravasi, Laura AU - Nakayama, Toshiyuki AU - Lang, Lixin AU - Schmidt, Kathleen C AU - Seidel, Jurgen AU - Green, Michael V AU - Sokoloff, Louis AU - Eckelman, William C AD - Positron Emission Tomography Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 259 EP - 266 VL - 34 IS - 2 SN - 1619-7070, 1619-7070 KW - 4-fluoro-N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyrimidinyl)benzamide KW - 0 KW - Anesthetics, Inhalation KW - Piperazines KW - Pyrimidines KW - Radiopharmaceuticals KW - Serotonin 5-HT1 Receptor Antagonists KW - Isoflurane KW - CYS9AKD70P KW - Index Medicus KW - Rats KW - Radiopharmaceuticals -- pharmacokinetics KW - Animals KW - Rats, Sprague-Dawley KW - Drug Interactions KW - Metabolic Clearance Rate -- drug effects KW - Radiopharmaceuticals -- blood KW - Tissue Distribution -- drug effects KW - Anesthetics, Inhalation -- administration & dosage KW - Male KW - Radionuclide Imaging KW - Piperazines -- pharmacokinetics KW - Brain -- drug effects KW - Brain -- metabolism KW - Pyrimidines -- pharmacokinetics KW - Brain -- diagnostic imaging KW - Isoflurane -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68934215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+nuclear+medicine+and+molecular+imaging&rft.atitle=Distribution+of+the+5-HT%281A%29+receptor+antagonist+%5B+%2818%29F%5DFPWAY+in+blood+and+brain+of+the+rat+with+and+without+isoflurane+anesthesia.&rft.au=Tokugawa%2C+Joji%3BRavasi%2C+Laura%3BNakayama%2C+Toshiyuki%3BLang%2C+Lixin%3BSchmidt%2C+Kathleen+C%3BSeidel%2C+Jurgen%3BGreen%2C+Michael+V%3BSokoloff%2C+Louis%3BEckelman%2C+William+C&rft.aulast=Tokugawa&rft.aufirst=Joji&rft.date=2007-02-01&rft.volume=34&rft.issue=2&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=European+journal+of+nuclear+medicine+and+molecular+imaging&rft.issn=16197070&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-06 N1 - Date created - 2007-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lethal and edema toxins in the pathogenesis of Bacillus anthracis septic shock: implications for therapy. AN - 68932754; 17095744 AB - Recent research regarding the structure and function of Bacillus anthracis lethal (LeTx) and edema (ETx) toxins provides growing insights into the pathophysiology and treatment of shock with this lethal bacteria. These are both binary-type toxins composed of protective antigen necessary for their cellular uptake and either lethal or edema factors, the toxigenic moieties. The primary cellular receptors for protective antigen have been identified and constructed and key steps in the extracellular processing and internalization of the toxins clarified. Consistent with the lethal factor's primary action as an intracellular endopeptidase targeting mitogen-activated protein kinase kinases, growing evidence indicates that shock with this toxin does not result from an excessive inflammatory response. In fact, the potent immunosuppressive effects of LeTx may actually contribute to the establishment and persistence of infection. Instead, shock with LeTx may be related to the direct injurious effects of lethal factor on endothelial cell function. Despite the importance of LeTx, very recent studies show that edema factor, a potent adenyl cyclase, has the ability to make a substantial contribution to shock caused by B. anthracis and works additively with LeTx. Furthermore, ETx may contribute to the immunosuppressive effects of LeTx. Therapies under development that target several different steps in the cellular uptake and function of these two toxins have been effective in in vitro and in vivo systems. Understanding how best to apply these agents clinically and how they interact with conventional treatments should be goals for future research. JF - American journal of respiratory and critical care medicine AU - Sherer, Kevin AU - Li, Yan AU - Cui, Xizhong AU - Eichacker, Peter Q AD - Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 211 EP - 221 VL - 175 IS - 3 SN - 1073-449X, 1073-449X KW - Antigens, Bacterial KW - 0 KW - Bacterial Toxins KW - anthrax toxin KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Animals KW - Disease Models, Animal KW - Drug Design KW - Antigens, Bacterial -- toxicity KW - Bacterial Toxins -- metabolism KW - Antigens, Bacterial -- metabolism KW - Anthrax -- immunology KW - Shock, Septic -- immunology KW - Shock, Septic -- drug therapy KW - Anthrax -- complications KW - Bacterial Toxins -- chemistry KW - Bacterial Toxins -- toxicity KW - Bacillus anthracis KW - Anthrax -- drug therapy KW - Antigens, Bacterial -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68932754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+and+critical+care+medicine&rft.atitle=Lethal+and+edema+toxins+in+the+pathogenesis+of+Bacillus+anthracis+septic+shock%3A+implications+for+therapy.&rft.au=Sherer%2C+Kevin%3BLi%2C+Yan%3BCui%2C+Xizhong%3BEichacker%2C+Peter+Q&rft.aulast=Sherer&rft.aufirst=Kevin&rft.date=2007-02-01&rft.volume=175&rft.issue=3&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+and+critical+care+medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-09 N1 - Date created - 2007-01-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Crit Care Med. 2004 Mar;32(3):858-73 [15090974] Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6367-72 [15079089] Crit Rev Microbiol. 2004;30(3):187-96 [15490970] J Infect Dis. 1966 Jun;116(3):377-89 [4957317] J Infect Dis. 1968 Feb;118(1):114-24 [5640983] J Infect Dis. 1968 Feb;118(1):85-96 [4966665] Proc Natl Acad Sci U S A. 1982 May;79(10):3162-6 [6285339] Science. 1998 May 1;280(5364):734-7 [9563949] Biochemistry. 1998 Nov 10;37(45):15737-46 [9843379] J Gen Microbiol. 1961 Sep;26:49-63 [13916257] Science. 1962 Dec 21;138(3547):1331-3 [14033353] Br J Exp Pathol. 1955 Oct;36(5):460-72 [13269658] Antimicrob Agents Chemother. 2005 Jan;49(1):88-96 [15616280] J Infect Dis. 2005 Feb 1;191(3):422-34 [15633102] Infect Immun. 2005 Feb;73(2):795-802 [15664918] J Exp Med. 2005 Feb 7;201(3):325-31 [15699068] EMBO J. 2005 Mar 9;24(5):929-41 [15719022] J Immunol. 2005 Apr 15;174(8):4934-41 [15814721] J Immunol. 2005 Apr 15;174(8):4966-71 [15814725] Am J Physiol Cell Physiol. 2005 Jun;288(6):C1402-10 [15689409] Am J Pathol. 2005 Jun;166(6):1871-81 [15920171] Clin Infect Dis. 2005 Jul 1;41(1):12-20 [15937757] Infect Immun. 2005 Jul;73(7):4238-44 [15972515] Hum Antibodies. 2003;12(4):129-35 [15156101] Nat Biotechnol. 2004 Jun;22(6):717-23 [15146199] Nat Rev Microbiol. 2004 Sep;2(9):721-6 [15372082] Am J Med Sci. 2004 Oct;328(4):215-9 [15486536] Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9499-504 [15983377] J Infect Dis. 2005 Sep 1;192(5):837-45 [16088833] Immunity. 2005 Sep;23(3):319-29 [16169504] Infect Immun. 2005 Oct;73(10):6547-51 [16177329] Infect Immun. 2005 Oct;73(10):7006-10 [16177381] Infect Immun. 2005 Oct;73(10):7069-73 [16177395] Am J Pathol. 2005 Nov;167(5):1309-20 [16251415] Infect Immun. 2005 Dec;73(12):8275-81 [16299324] Infect Immun. 2005 Dec;73(12):8362-8 [16299334] Infect Immun. 2006 Feb;74(2):1016-24 [16428748] Mol Microbiol. 2006 Jul;61(2):324-37 [16856939] Am J Pathol. 2006 Aug;169(2):433-44 [16877346] Infect Immun. 2006 Feb;74(2):1266-72 [16428776] Nat Genet. 2006 Feb;38(2):240-4 [16429160] J Infect Dis. 2006 Mar 1;193(5):625-33 [16453257] J Infect Dis. 2006 Mar 15;193(6):829-40 [16479518] Ann Intern Med. 2006 Feb 21;144(4):270-80 [16490913] J Immunol. 2006 May 15;176(10):6155-61 [16670324] J Infect Dis. 2007 Feb 15;195(4):572-80 [17230417] Infect Immun. 1985 Jan;47(1):306-10 [3917427] Vaccine. 1984 Jun;2(2):125-32 [6442500] J Exp Med. 1986 Nov 1;164(5):1700-9 [3021891] Pharmacol Ther. 1990;47(3):329-45 [1963221] Infect Immun. 1991 Oct;59(10):3472-7 [1910002] Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10198-201 [8234277] Infect Immun. 1994 Oct;62(10):4432-9 [7927706] Infect Immun. 1995 Jan;63(1):82-7 [7806387] Nature. 1997 Feb 27;385(6619):833-8 [9039918] FEBS Lett. 1999 Nov 26;462(1-2):199-204 [10580119] Infect Immun. 2001 Feb;69(2):1175-7 [11160016] Cell Microbiol. 2000 Jun;2(3):259-64 [11207582] Science. 2001 Apr 27;292(5517):695-7 [11326092] Mod Pathol. 2001 May;14(5):482-95 [11353060] J Biol Chem. 2001 Jun 22;276(25):22090-4 [11278644] Infect Immun. 2001 Oct;69(10):6532-6 [11553601] Nature. 2001 Nov 8;414(6860):225-9 [11700562] Nature. 2001 Nov 8;414(6860):229-33 [11700563] Proc Natl Acad Sci U S A. 2002 May 14;99(10):7045-8 [11997437] Nat Biotechnol. 2002 Jun;20(6):597-601 [12042864] Biochem Biophys Res Commun. 2002 Apr 26;293(1):349-55 [12054607] Nature. 2002 Jul 25;418(6896):386 [12140548] Emerg Infect Dis. 2002 Oct;8(10):1019-28 [12396909] J Cell Biol. 2003 Feb 3;160(3):321-8 [12551953] Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5170-4 [12700348] J Biol Chem. 2003 Jul 11;278(28):25990-7 [12676933] Nature. 2003 Jul 17;424(6946):329-34 [12867985] J Biol Chem. 2003 Aug 1;278(31):29261-6 [12724328] J Clin Invest. 2003 Sep;112(5):670-82 [12952916] Annu Rev Cell Dev Biol. 2003;19:45-70 [14570563] Nat Biotechnol. 2003 Nov;21(11):1305-6 [14555959] Infect Immun. 2004 Jan;72(1):430-9 [14688124] Infect Immun. 2004 Jan;72(1):602-5 [14688144] J Immunol. 2004 Jan 15;172(2):747-51 [14707042] Nat Struct Mol Biol. 2004 Jan;11(1):60-6 [14718924] Nat Struct Mol Biol. 2004 Jan;11(1):67-72 [14718925] Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3242-7 [14978283] Am J Physiol Regul Integr Comp Physiol. 2004 Apr;286(4):R699-709 [14715494] EMBO Rep. 2004 Apr;5(4):418-22 [15031715] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Beryllium-induced TNF-alpha production is transcription-dependent in chronic beryllium disease. AN - 68926673; 16980557 AB - Beryllium (Be)-antigen presentation to Be-specific CD4(+) T cells from the lungs of patients with chronic beryllium disease (CBD) results in T cell proliferation and TNF-alpha secretion. We tested the hypothesis that Be-induced, CBD bronchoalveolar lavage (BAL) T cell, transcription-dependent, TNF-alpha secretion was accompanied by specific transcription factor upregulation. After 6 h of Be stimulation, CBD BAL cells produced a median of 883 pg/ml TNF-alpha (range, 608-1,275 pg/ml) versus 198 pg/ml (range, 116-245 pg/ml) by unstimulated cells. After 12 h CBD BAL cells produced a median of 2,963 pg/ml (range, 99-9,424 pg/ml) TNF-alpha versus 55 pg/ml (range, 0-454) by unstimulated cells. Using real-time RT-PCR, Be-stimulated TNF-alpha production at 6 h was preceded by a 5-fold increase in TNF-alpha pre-mRNA copy number:beta-actin copy number (Be median ratio 0.21; unstimulated median ratio 0.04). The median ratio of mature TNF-alpha mRNA:beta-actin mRNA was upregulated 1.4-fold (Be median ratio 0.17; unstimulated median ratio 0.12). Be exposure in the presence of the transcription inhibitor pentoxifylline (PTX) decreased CBD BAL cell TNF-alpha pre-mRNA levels > 60%, whereas treatment with the mRNA splicing inhibitor 2-aminopurine (2AP) decreased levels 40% relative to Be exposure alone. PTX treatment decreased mature TNF-alpha mRNA levels 50% while 2AP decreased levels > 80%, relative to Be exposure alone. Beryllium exposure specifically upregulated transcription factors AP-1 and NF-kappaB. The data suggest that Be exposure induces transcription-dependent TNF-alpha production, potentially due to upregulation of specific transcription factors. JF - American journal of respiratory cell and molecular biology AU - Sawyer, Richard T AU - Fontenot, Andrew P AU - Barnes, Tristan A AU - Parsons, Charles E AU - Tooker, Brian C AU - Maier, Lisa A AU - Gillespie, May M AU - Gottschall, E Brigitte AU - Silveira, Lori AU - Hagman, James AU - Newman, Lee S AD - Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA. sawyerr@niaid.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 191 EP - 200 VL - 36 IS - 2 SN - 1044-1549, 1044-1549 KW - Lipopolysaccharides KW - 0 KW - NF-kappa B KW - Nuclear Proteins KW - RNA Precursors KW - RNA, Messenger KW - Transcription Factor AP-1 KW - Transcription Factors KW - Tumor Necrosis Factor-alpha KW - Beryllium KW - OW5102UV6N KW - Index Medicus KW - RNA Precursors -- metabolism KW - Transcription Factors -- metabolism KW - Transcription Factor AP-1 -- metabolism KW - Humans KW - Lipopolysaccharides -- pharmacology KW - CD4-Positive T-Lymphocytes -- immunology KW - Up-Regulation -- genetics KW - Cell Separation KW - RNA, Messenger -- genetics KW - CD4-Positive T-Lymphocytes -- drug effects KW - RNA, Messenger -- metabolism KW - Kinetics KW - Up-Regulation -- drug effects KW - Adult KW - Middle Aged KW - Nuclear Proteins -- metabolism KW - Gene Dosage KW - Bronchoalveolar Lavage Fluid -- cytology KW - Female KW - Male KW - NF-kappa B -- metabolism KW - Transcription, Genetic -- drug effects KW - Tumor Necrosis Factor-alpha -- biosynthesis KW - Tumor Necrosis Factor-alpha -- metabolism KW - Tumor Necrosis Factor-alpha -- genetics KW - Berylliosis -- genetics KW - Beryllium -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68926673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=Beryllium-induced+TNF-alpha+production+is+transcription-dependent+in+chronic+beryllium+disease.&rft.au=Sawyer%2C+Richard+T%3BFontenot%2C+Andrew+P%3BBarnes%2C+Tristan+A%3BParsons%2C+Charles+E%3BTooker%2C+Brian+C%3BMaier%2C+Lisa+A%3BGillespie%2C+May+M%3BGottschall%2C+E+Brigitte%3BSilveira%2C+Lori%3BHagman%2C+James%3BNewman%2C+Lee+S&rft.aulast=Sawyer&rft.aufirst=Richard&rft.date=2007-02-01&rft.volume=36&rft.issue=2&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+cell+and+molecular+biology&rft.issn=10441549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-28 N1 - Date created - 2007-01-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicology. 2000 Mar 7;143(3):235-47 [10755710] Nat Immunol. 2006 Mar;7(3):311-7 [16462739] Am J Respir Cell Mol Biol. 2004 Jul;31(1):122-30 [14975942] J Biol Chem. 2000 Jun 16;275(24):18432-40 [10748079] Eur Respir J. 2001 Mar;17(3):403-15 [11405518] Am J Respir Crit Care Med. 2001 Oct 1;164(7):1192-9 [11673208] Int Immunopharmacol. 2002 Feb;2(2-3):249-61 [11811929] Am J Respir Crit Care Med. 2002 Mar 15;165(6):788-94 [11897645] Immunity. 2002 Nov;17(5):605-15 [12433367] J Clin Invest. 2002 Nov;110(10):1473-82 [12438445] Eur Respir J. 2002 Nov;20(5):1174-8 [12449171] Clin Chest Med. 2002 Dec;23(4):827-39 [12516537] Immunity. 2003 Jul;19(1):59-70 [12871639] J Clin Invest. 2003 Sep;112(5):776-84 [12952926] Am J Respir Cell Mol Biol. 2004 Oct;31(4):470-7 [15256386] Am Rev Respir Dis. 1978 Dec;118(6 Pt 2):1-120 [742764] Am Rev Respir Dis. 1987 Mar;135(3):696-704 [3826895] Biochem Biophys Res Commun. 1988 Sep 30;155(3):1230-6 [2460096] N Engl J Med. 1989 Apr 27;320(17):1103-9 [2469014] Am Rev Respir Dis. 1989 Jun;139(6):1479-86 [2729754] J Exp Med. 1990 Jul 1;172(1):391-4 [2358784] J Immunol. 1991 Mar 15;146(6):1843-8 [1848573] J Allergy Clin Immunol. 1991 Jul;88(1):54-60 [2071785] Surgery. 1991 Aug;110(2):192-8 [1858029] Science. 1993 Oct 8;262(5131):242-4 [8105536] Am Rev Respir Dis. 1993 Oct;148(4 Pt 1):985-91 [8214955] Annu Rev Cell Biol. 1993;9:317-43 [8280464] Am J Respir Cell Mol Biol. 1994 May;10(5):506-13 [8179912] Mol Cell Biol. 1996 Jun;16(6):2814-22 [8649390] J Immunol. 1997 Jan 1;158(1):518-26 [8977230] Am J Respir Crit Care Med. 1997 Dec;156(6):1884-91 [9412570] J Exp Med. 1998 Jul 20;188(2):247-54 [9670037] J Immunol. 1999 Sep 1;163(5):2747-53 [10453017] J Allergy Clin Immunol. 2005 May;115(5):1036-42 [15867863] J Occup Environ Med. 2005 Dec;47(12):1218-26 [16340702] Toxicology. 2006 Feb 1;218(2-3):216-28 [16314022] Toxicology. 2000 Mar 7;143(3):249-61 [10755711] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Targeted disruption of Kaposi's sarcoma-associated herpesvirus ORF57 in the viral genome is detrimental for the expression of ORF59, K8alpha, and K8.1 and the production of infectious virus. AN - 68925039; 17108026 AB - Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 regulates viral gene expression at the posttranscriptional level during viral lytic infection. To study its function in the context of the viral genome, we disrupted KSHV ORF57 in the KSHV genome by transposon-based mutagenesis. The insertion of the transposon into the ORF57 exon 2 region also interrupted the 3' untranslated region of KSHV ORF56, which overlaps with the ORF57 coding region. The disrupted viral genome, Bac36-Delta57, did not express ORF57, ORF59, K8alpha, K8.1, or a higher level of polyadenylated nuclear RNA after butyrate induction and could not be induced to produce infectious viruses in the presence of valproic acid, a histone deacetylase inhibitor and a novel KSHV lytic cycle inducer. The ectopic expression of ORF57 partially complemented the replication deficiency of the disrupted KSHV genome and the expression of the lytic gene ORF59. The induced production of infectious virus particles from the disrupted KSHV genome was also substantially restored by the simultaneous expression of both ORF57 and ORF56; complementation by ORF57 alone only partially restored the production of virus, and expression of ORF56 alone showed no effect. Altogether, our data indicate that in the context of the viral genome, KSHV ORF57 is essential for ORF59, K8alpha, and K8.1 expression and infectious virus production. JF - Journal of virology AU - Majerciak, Vladimir AU - Pripuzova, Natalia AU - McCoy, J Philip AU - Gao, Shou-Jiang AU - Zheng, Zhi-Ming AD - HIV and AIDS Malignancy Branch, Center for Cancer Research, NCI/NIH, 10 Center Dr., Rm. 10 S255, MSC-1868, Bethesda, MD 20892-1868, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 1062 EP - 1071 VL - 81 IS - 3 SN - 0022-538X, 0022-538X KW - Glycoproteins KW - 0 KW - K8.1 protein, Human herpesvirus 8 KW - ORF59 protein, Human herpesvirus 8 KW - Viral Proteins KW - Index Medicus KW - Virus Replication KW - Viral Proteins -- genetics KW - Glycoproteins -- metabolism KW - Open Reading Frames KW - Viral Proteins -- metabolism KW - Glycoproteins -- genetics KW - Cell Line KW - Genome, Viral -- drug effects KW - Genome, Viral -- genetics KW - Gene Expression Regulation, Viral -- physiology KW - Herpesvirus 8, Human -- physiology KW - Sarcoma, Kaposi -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68925039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Targeted+disruption+of+Kaposi%27s+sarcoma-associated+herpesvirus+ORF57+in+the+viral+genome+is+detrimental+for+the+expression+of+ORF59%2C+K8alpha%2C+and+K8.1+and+the+production+of+infectious+virus.&rft.au=Majerciak%2C+Vladimir%3BPripuzova%2C+Natalia%3BMcCoy%2C+J+Philip%3BGao%2C+Shou-Jiang%3BZheng%2C+Zhi-Ming&rft.aulast=Majerciak&rft.aufirst=Vladimir&rft.date=2007-02-01&rft.volume=81&rft.issue=3&rft.spage=1062&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-06 N1 - Date created - 2007-01-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 2000 Jan;74(2):1038-44 [10623771] J Virol. 2003 May;77(10):5578-88 [12719550] AIDS. 2000 May 5;14(7):899-902 [10839602] J Virol. 2000 Dec;74(23):10920-9 [11069986] J Virol. 2001 Feb;75(3):1487-506 [11152521] J Virol. 2001 Mar;75(6):2921-8 [11222717] J Virol. 2001 Apr;75(7):3250-8 [11238851] J Virol. 2001 Aug;75(15):6786-99 [11435557] EMBO J. 2001 Oct 15;20(20):5769-78 [11598019] EMBO J. 2001 Dec 17;20(24):6969-78 [11742974] J Biol Chem. 2002 Apr 26;277(17):14547-56 [11832484] Rev Med Virol. 2003 May-Jun;13(3):173-84 [12740832] N Engl J Med. 1996 May 16;334(20):1292-7 [8609946] Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6641-6 [8692871] Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11883-8 [8876232] Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14862-7 [8962146] J Virol. 1997 Jun;71(6):4187-92 [9151804] J Virol. 1998 Jul;72(7):6228-32 [9621095] J Virol. 1998 Aug;72(8):6725-31 [9658120] Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10866-71 [9724796] Virology. 1998 Sep 15;249(1):140-9 [9740785] Virology. 1998 Dec 20;252(2):304-12 [9878608] J Virol. 1999 Feb;73(2):1341-9 [9882339] J Virol. 1999 Feb;73(2):1438-46 [9882349] J Virol. 1999 Mar;73(3):1909-17 [9971770] Virology. 1999 Apr 25;257(1):84-94 [10208923] Science. 1999 Apr 23;284(5414):641-4 [10213686] Prog Neurobiol. 1999 May;58(1):31-59 [10321796] J Virol. 1999 Jul;73(7):5556-67 [10364304] J Virol. 1999 Nov;73(11):9348-61 [10516043] J Virol. 2005 Mar;79(6):3479-87 [15731242] Biochem J. 2005 Apr 15;387(Pt 2):295-308 [15537388] Blood. 2005 May 15;105(10):4028-34 [15687238] J Cell Biochem. 2005 Jul 1;95(4):698-711 [15880690] J Virol. 2005 Sep;79(17):10952-67 [16103147] J Clin Pharm Ther. 2005 Oct;30(5):417-21 [16164485] Virology. 2005 Sep 30;340(2):183-91 [16043206] J Virol. 2005 Nov;79(22):14207-21 [16254356] J Pathol. 2006 Jan;208(2):187-98 [16362980] Nat Rev Cancer. 2006 Jan;6(1):38-51 [16397526] J Virol. 2006 Jun;80(11):5251-60 [16699005] J Virol. 2006 Jul;80(14):7037-51 [16809309] J Biol Chem. 2006 Sep 22;281(38):28365-78 [16829516] J Virol. 2006 Dec;80(24):11968-81 [17020939] J Virol. 2003 Sep;77(17):9590-612 [12915572] J Biol Chem. 2003 Sep 26;278(39):37790-8 [12857728] J Virol. 2004 Mar;78(5):2609-14 [14963167] J Virol. 2004 Jun;78(12):6389-98 [15163732] Virology. 2004 Aug 1;325(2):225-40 [15246263] J Biol Chem. 2004 Jul 30;279(31):33001-11 [15155762] J Virol. 2004 Oct;78(20):11121-9 [15452232] Science. 1994 Dec 16;266(5192):1865-9 [7997879] Nat Med. 1996 Mar;2(3):342-6 [8612236] J Virol. 2002 Jun;76(12):6185-96 [12021352] J Virol. 2002 Nov;76(22):11596-604 [12388720] J Virol. 2002 Nov;76(22):11677-87 [12388727] J Virol. 2000 Apr;74(8):3586-97 [10729134] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The ERK mitogen-activated protein kinase pathway contributes to Ebola virus glycoprotein-induced cytotoxicity. AN - 68923678; 17108034 AB - Ebola virus is a highly lethal pathogen that causes hemorrhagic fever in humans and nonhuman primates. Among the seven known viral gene products, the envelope glycoprotein (GP) alone induces cell rounding and detachment that ultimately leads to cell death. Cellular cytoxicity is not seen with comparable levels of expression of a mutant form of GP lacking a mucin-like domain (GPDeltamuc). GP-induced cell death is nonapoptotic and is preceded by downmodulation of cell surface molecules involved in signaling pathways, including certain integrins and epidermal growth factor receptor. To investigate the mechanism of GP-induced cellular toxicity, we analyzed the activation of several signal transduction pathways involved in cell growth and survival. The active form of extracellular signal-regulated kinases types 1 and 2 (ERK1/2), phospho-ERK1/2, was reduced in cells expressing GP compared to those expressing GPDeltamuc as determined by flow cytometry, in contrast to the case for several other signaling proteins. Subsequent analysis of the activation states and kinase activities of related kinases revealed a more pronounced effect on the ERK2 kinase isoform. Disruption of ERK2 activity by a dominant negative ERK or by small interfering RNA-mediated ERK2 knockdown potentiated the decrease in alphaV integrin expression associated with toxicity. Conversely, activation of the pathway through the expression of a constitutively active form of ERK2 significantly protected against this effect. These results indicate that the ERK signaling cascade mediates GP-mediated cytotoxicity and plays a role in pathogenicity induced by this gene product. JF - Journal of virology AU - Zampieri, Carisa A AU - Fortin, Jean-Francois AU - Nolan, Garry P AU - Nabel, Gary J AD - Vaccine Research Center, NIAID, National Institutes of Health, Room 4502, Bldg. 40, MSC-3005, 40 Convent Drive, Bethesda, MD 20892-3005, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 1230 EP - 1240 VL - 81 IS - 3 SN - 0022-538X, 0022-538X KW - Viral Envelope Proteins KW - 0 KW - Extracellular Signal-Regulated MAP Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Gene Expression Regulation, Viral KW - Viral Envelope Proteins -- pharmacology KW - Extracellular Signal-Regulated MAP Kinases -- metabolism KW - Ebolavirus -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68923678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=The+ERK+mitogen-activated+protein+kinase+pathway+contributes+to+Ebola+virus+glycoprotein-induced+cytotoxicity.&rft.au=Zampieri%2C+Carisa+A%3BFortin%2C+Jean-Francois%3BNolan%2C+Garry+P%3BNabel%2C+Gary+J&rft.aulast=Zampieri&rft.aufirst=Carisa&rft.date=2007-02-01&rft.volume=81&rft.issue=3&rft.spage=1230&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-06 N1 - Date created - 2007-01-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Virology. 2000 Dec 5;278(1):20-6 [11112476] Eur Cytokine Netw. 2000 Sep;11(3):470-7 [11022134] Nat Cell Biol. 2001 Mar;3(3):301-5 [11231581] J Cell Biol. 2001 Apr 16;153(2):273-82 [11309409] J Virol. 2001 May;75(10):4871-7 [11312358] Virology. 2001 Jul 20;286(1):91-9 [11448162] J Biol Chem. 2001 Oct 19;276(42):38353-60 [11459835] J Virol. 2002 Jan;76(2):817-28 [11752171] Curr Opin Genet Dev. 2002 Feb;12(1):30-5 [11790551] J Virol. 2002 Mar;76(5):2518-28 [11836430] J Virol. 2002 Apr;76(7):3365-73 [11884562] Nat Cell Biol. 2002 Apr;4(4):E65-8 [11944032] J Cell Sci. 2002 Jul 1;115(Pt 13):2781-90 [12077368] EMBO Rep. 2003 Oct;4(10):964-8 [14502223] Genes Cells. 2003 Nov;8(11):847-56 [14622137] J Infect Dis. 2003 Dec 1;188(11):1618-29 [14639531] Oncogene. 2004 Jul 1;23(30):5227-41 [15122343] Anal Biochem. 1976 May 7;72:248-54 [942051] Intervirology. 1982;18(1-2):24-32 [7118520] Semin Cancer Biol. 1994 Aug;5(4):261-8 [7803762] Science. 1998 Feb 13;279(5353):1034-7 [9461435] J Cell Biol. 1998 Mar 9;140(5):1255-63 [9490736] J Virol. 1998 Apr;72(4):3155-60 [9525641] Proc Natl Acad Sci U S A. 1998 May 12;95(10):5762-7 [9576958] J Virol. 1998 Nov;72(11):9173-80 [9765464] Oncogene. 1998 Sep 10;17(10):1271-7 [9771970] Curr Biol. 1998 Oct 22;8(21):1141-50 [9799732] Curr Top Microbiol Immunol. 1999;235:145-73 [9893383] Curr Opin Cell Biol. 1999 Apr;11(2):197-202 [10209147] Immunology. 1999 Apr;96(4):524-8 [10233737] Science. 1999 Aug 13;285(5430):1028-32 [10446041] Mol Biol Cell. 1999 Oct;10(10):3197-204 [10512860] J Virol. 2005 Jan;79(1):547-53 [15596847] J Gen Virol. 2005 Apr;86(Pt 4):1027-33 [15784896] J Virol. 2005 Sep;79(17):11366-81 [16103188] Nat Cell Biol. 2005 Sep;7(9):901-8 [16113676] Immunity. 2005 Oct;23(4):431-43 [16226508] Growth Factors. 2006 Mar;24(1):21-44 [16393692] J Gen Virol. 2006 May;87(Pt 5):1247-57 [16603527] Nat Cell Biol. 2006 May;8(5):432-3 [16691207] Cell Cycle. 2006 Oct;5(19):2179-82 [16969102] J Biol. 2006;5(5):14 [16805921] Science. 1999 Nov 12;286(5443):1374-7 [10558995] Mol Cell Biol. 2000 Mar;20(6):2218-27 [10688668] J Virol. 2000 May;74(10):4933-7 [10775638] Nat Med. 2000 Aug;6(8):886-9 [10932225] J Gen Virol. 2000 Sep;81(Pt 9):2155-9 [10950971] Curr Opin Genet Dev. 2001 Feb;11(1):48-53 [11163150] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fetal onset of aberrant gene expression relevant to pulmonary carcinogenesis in lung adenocarcinoma development induced by in utero arsenic exposure. AN - 68419778; 17077188 AB - Arsenic is a human pulmonary carcinogen. Our work indicates that in utero arsenic exposure in mice can induce or initiate lung cancer in female offspring. To define early molecular changes, pregnant C3H mice were given 85 ppm arsenic in drinking water from days 8 to 18 of gestation and expression of selected genes in the fetal lung or in lung tumors developing in adults was examined. Transplacental arsenic exposure increased estrogen receptor-alpha (ER-alpha) transcript and protein levels in the female fetal lung. An overexpression of various estrogen-regulated genes also occurred, including trefoil factor-3, anterior gradient-2, and the steroid metabolism genes 17-beta-hydroxysteroid dehydrogenase type 5 and aromatase. The insulin growth factor system, which can be influenced by ER and has been implicated in the pulmonary oncogenic process, was activated in fetal lung after gestational arsenic exposure. In utero arsenic exposure also induced overexpression of alpha-fetoprotein, epidermal growth factor receptor, L-myc, and metallothionein-1 in fetal lung, all of which are associated with lung cancer. Lung adenoma and adenocarcinoma from adult female mice exposed to arsenic in utero showed widespread, intense nuclear ER-alpha expression. In contrast, normal adult lung and diethylnitrosamine-induced lung adenocarcinoma showed little evidence of ER-alpha expression. Thus, transplacental arsenic exposure at a carcinogenic dose produced aberrant estrogen-linked pulmonary gene expression. ER-alpha activation was specifically associated with arsenic-induced lung adenocarcinoma and adenoma but not with nitrosamine-induced lung tumors. These data provide evidence that arsenic-induced aberrant ER signaling could disrupt early life stage genetic programing in the lung leading eventually to lung tumor formation much later in adulthood. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Shen, Jun AU - Liu, Jie AU - Xie, Yaxiong AU - Diwan, Bhalchandra A AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 313 EP - 320 VL - 95 IS - 2 SN - 1096-6080, 1096-6080 KW - Arsenites KW - 0 KW - Carcinogens, Environmental KW - Sodium Compounds KW - sodium arsenite KW - 48OVY2OC72 KW - Index Medicus KW - Animals KW - Blotting, Western KW - Gestational Age KW - Mice, Inbred C3H KW - Mice KW - Immunohistochemistry KW - Female KW - Pregnancy KW - Lung Neoplasms -- embryology KW - Prenatal Exposure Delayed Effects -- chemically induced KW - Arsenites -- toxicity KW - Sodium Compounds -- toxicity KW - Lung -- drug effects KW - Lung Neoplasms -- genetics KW - Lung -- embryology KW - Lung Neoplasms -- chemically induced KW - Lung -- metabolism KW - Carcinogens, Environmental -- toxicity KW - Gene Expression Regulation, Developmental -- drug effects KW - Prenatal Exposure Delayed Effects -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68419778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Fetal+onset+of+aberrant+gene+expression+relevant+to+pulmonary+carcinogenesis+in+lung+adenocarcinoma+development+induced+by+in+utero+arsenic+exposure.&rft.au=Shen%2C+Jun%3BLiu%2C+Jie%3BXie%2C+Yaxiong%3BDiwan%2C+Bhalchandra+A%3BWaalkes%2C+Michael+P&rft.aulast=Shen&rft.aufirst=Jun&rft.date=2007-02-01&rft.volume=95&rft.issue=2&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-05 N1 - Date created - 2007-01-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pathol. 2000 Feb;190(2):133-42 [10657010] Mol Cancer Ther. 2003 Nov;2(11):1243-55 [14617798] Toxicol Sci. 2004 Feb;77(2):249-57 [14691202] J Natl Cancer Inst. 2004 Mar 17;96(6):466-74 [15026472] Curr Oncol Rep. 2004 Jul;6(4):259-67 [15161576] Clin Lung Cancer. 2004 May;5(6):353-9 [15217534] Growth Horm IGF Res. 2004 Aug;14(4):261-9 [15231294] Toxicol Appl Pharmacol. 2004 Aug 1;198(3):366-76 [15276416] Toxicol Appl Pharmacol. 2004 Aug 1;198(3):394-404 [15276419] Carcinogenesis. 2004 Sep;25(9):1779-86 [15073043] Toxicol Appl Pharmacol. 2004 Sep 1;199(2):162-74 [15313588] Am J Pathol. 1998 Dec;153(6):1775-85 [9846968] Biochem Biophys Res Commun. 2005 Jan 7;326(1):218-27 [15567174] Am J Respir Cell Mol Biol. 2005 Jan;32(1):65-71 [15514114] Exp Oncol. 2004 Dec;26(4):316-9 [15627066] J Soc Gynecol Investig. 2005 Jan;12(1):58-64 [15629674] Cancer Res. 2005 Feb 15;65(4):1459-70 [15735034] Endocr Relat Cancer. 2005 Mar;12(1):101-7 [15788642] Cancer Res. 2005 May 1;65(9):3796-805 [15867376] J Natl Cancer Inst. 2005 May 4;97(9):643-55 [15870435] J Clin Oncol. 2005 May 10;23(14):3212-8 [15886308] Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8644-9 [15937110] Toxicol Appl Pharmacol. 2005 Aug 15;206(3):288-98 [16039940] Cancer Res. 2005 Dec 15;65(24):11287-91 [16357134] Cancer Res. 2006 Feb 1;66(3):1337-45 [16452187] Environ Health Perspect. 2006 Mar;114(3):404-11 [16507464] Toxicol Sci. 2006 Jun;91(2):372-81 [16543296] Toxicology. 2006 Jul 5;224(1-2):147-55 [16753250] Environ Health Perspect. 2006 Aug;114(8):1293-6 [16882542] Carcinogenesis. 2004 Jan;25(1):133-41 [14514661] Mutat Res. 2003 Dec 10;533(1-2):37-65 [14643412] Toxicol Appl Pharmacol. 2006 Sep 15;215(3):295-305 [16712894] Cancer Lett. 2003 Jun 10;195(2):127-37 [12767520] Toxicol Appl Pharmacol. 2003 Jan 1;186(1):7-17 [12583988] Annu Rev Med. 2003;54:73-87 [12471176] Expert Rev Anticancer Ther. 2002 Dec;2(6):709-35 [12503217] Biochem Cell Biol. 2002;80(3):335-41 [12123286] Prostate. 2002 Aug 1;52(3):236-44 [12111698] Lung Cancer. 2002 May;36(2):125-32 [11955646] Pathol Int. 2002 Jan;52(1):46-53 [11940206] Mol Cell Endocrinol. 2002 Feb 25;188(1-2):125-40 [11911952] Toxicol Appl Pharmacol. 2001 May 1;172(3):249-61 [11312654] Toxicol Appl Pharmacol. 2000 Jul 1;166(1):24-35 [10873715] Environ Health Perspect. 2000 Jun;108 Suppl 3:573-94 [10852857] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inhibition of urethane-induced carcinogenicity in cyp2e1-/- in comparison to cyp2e1+/+ mice. AN - 68419053; 17093202 AB - Urethane is an established animal carcinogen and has been classified as "reasonably anticipated to be a human carcinogen." Until recently, urethane metabolism via esterase was considered the main metabolic pathway of this chemical. However, recent studies in this laboratory showed that CYP2E1, and not esterase, is the primary enzyme responsible for urethane oxidation. Subsequent studies demonstrated significant inhibition of urethane-induced genotoxicity and cell proliferation in Cyp2e1-/- compared to Cyp2e1+/+ mice. Using Cyp2e1-/- mice, current studies were undertaken to assess the relationships between urethane metabolism and carcinogenicity. Urethane was administered via gavage at 1, 10, or 100 mg/kg/day, 5 days/week, for 6 weeks. Animals were kept without chemical administration for 7 months after which they were euthanized, and urethane carcinogenicity was assessed. Microscopic examination showed a significant reduction in the incidences of liver hemangiomas and hemangiosarcomas in Cyp2e1-/- compared to Cyp2e+/+ mice. Lung nodules increased in a dose-dependent manner and were less prevalent in Cyp2e1-/- compared to Cyp2e+/+ mice. Microscopic alterations included bronchoalveolar adenomas, and in one Cyp2e1+/+ mouse treated with 100 mg/kg urethane, a bronchoalveolar carcinoma was diagnosed. Significant reduction in the incidence of adenomas and the number of adenomas/lung were observed in Cyp2e1-/- compared to Cyp2e1+/+ mice. In the Harderian gland, the incidences of hyperplasia and adenomas were significantly lower in Cyp2e1-/- compared to Cyp2e+/+ mice at the 10 mg/kg dose, with no significant differences observed at the high or low doses. In conclusion, this work demonstrated a significant reduction of urethane-induced carcinogenicity in Cyp2e1-/- compared to Cyp2e1+/+ mice and proved that CYP2E1-mediated oxidation plays an essential role in urethane-induced carcinogenicity. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Ghanayem, Burhan I AD - Laboratory of Pharmacology and Chemistry, National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. ghanayem@niehs.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 331 EP - 339 VL - 95 IS - 2 SN - 1096-6080, 1096-6080 KW - Urethane KW - 3IN71E75Z5 KW - vinyl carbamate epoxide KW - 82617-23-0 KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - Index Medicus KW - Animals KW - Inactivation, Metabolic KW - Mice KW - Male KW - Mice, Knockout KW - Lung Neoplasms -- enzymology KW - Liver Neoplasms -- enzymology KW - Liver Neoplasms -- chemically induced KW - Cytochrome P-450 CYP2E1 -- metabolism KW - Cytochrome P-450 CYP2E1 -- genetics KW - Urethane -- pharmacokinetics KW - Liver Neoplasms -- pathology KW - Harderian Gland -- pathology KW - Eye Neoplasms -- chemically induced KW - Urethane -- analogs & derivatives KW - Harderian Gland -- enzymology KW - Eye Neoplasms -- pathology KW - Lung Neoplasms -- chemically induced KW - Urethane -- toxicity KW - Lung Neoplasms -- pathology KW - Eye Neoplasms -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68419053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Inhibition+of+urethane-induced+carcinogenicity+in+cyp2e1-%2F-+in+comparison+to+cyp2e1%2B%2F%2B+mice.&rft.au=Ghanayem%2C+Burhan+I&rft.aulast=Ghanayem&rft.aufirst=Burhan&rft.date=2007-02-01&rft.volume=95&rft.issue=2&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-05 N1 - Date created - 2007-01-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Estrogen signaling and disruption of androgen metabolism in acquired androgen-independence during cadmium carcinogenesis in human prostate epithelial cells. AN - 68377010; 17075824 AB - Lethal prostate cancers often become androgen-independent due to androgen receptor (AR) overexpression. The role of cadmium in prostate tumor progression was determined. Control and cadmium-transformed prostate epithelial cells (CTPE) were compared for steroid-induced proliferation, steroid receptor expression, and androgen metabolism. CTPE cells showed rapid proliferation in complete medium and sustained proliferation in steroid-reduced medium. Androgens stimulated significantly less cell proliferation and AR-related genes expression in CTPE cells. 5alpha-Dihydrotestosterone increased PSA expression more effectively in control cells. Flutamide reduced 5alpha-dihydrotestosterone-stimulated growth less effectively in CTPE cells compared to control. CTPE cells showed decreased p27 expression. Estrogen receptors were overexpressed and estradiol markedly stimulated proliferation in CTPE cells. In CTPE cells 5alpha-aromatase was markedly increased, while 5alpha-reductase was decreased. Cadmium-induced malignant transformation stimulates androgen independence, unrelated to AR expression or activity. Increased estrogen receptor and 5alpha-aromatase expression suggest estrogen signaling may be critical to this process. (c) 2006 Wiley-Liss, Inc. JF - The Prostate AU - Benbrahim-Tallaa, Lamia AU - Liu, Jie AU - Webber, Mukta M AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 135 EP - 145 VL - 67 IS - 2 SN - 0270-4137, 0270-4137 KW - Androgen Antagonists KW - 0 KW - Androgens KW - Estrogens KW - RNA, Messenger KW - Receptors, Androgen KW - Receptors, Estrogen KW - Cadmium KW - 00BH33GNGH KW - Dihydrotestosterone KW - 08J2K08A3Y KW - Estradiol KW - 4TI98Z838E KW - Flutamide KW - 76W6J0943E KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Prostate -- drug effects KW - Androgen Antagonists -- pharmacology KW - Receptors, Androgen -- genetics KW - Humans KW - Estradiol -- pharmacology KW - Prostate -- metabolism KW - Disease Progression KW - Receptors, Estrogen -- metabolism KW - Receptors, Estrogen -- genetics KW - RNA, Messenger -- metabolism KW - Dihydrotestosterone -- pharmacology KW - Receptors, Androgen -- metabolism KW - Cadmium -- toxicity KW - Flutamide -- pharmacology KW - Gene Expression Regulation -- drug effects KW - Cell Line, Transformed KW - Male KW - Prostatic Neoplasms -- metabolism KW - Epithelial Cells -- metabolism KW - Estrogens -- genetics KW - Epithelial Cells -- drug effects KW - Estrogens -- metabolism KW - Cell Transformation, Neoplastic -- metabolism KW - Prostatic Neoplasms -- chemically induced KW - Cell Transformation, Neoplastic -- drug effects KW - Androgens -- pharmacology KW - Signal Transduction KW - Androgens -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68377010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Prostate&rft.atitle=Estrogen+signaling+and+disruption+of+androgen+metabolism+in+acquired+androgen-independence+during+cadmium+carcinogenesis+in+human+prostate+epithelial+cells.&rft.au=Benbrahim-Tallaa%2C+Lamia%3BLiu%2C+Jie%3BWebber%2C+Mukta+M%3BWaalkes%2C+Michael+P&rft.aulast=Benbrahim-Tallaa&rft.aufirst=Lamia&rft.date=2007-02-01&rft.volume=67&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=The+Prostate&rft.issn=02704137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-20 N1 - Date created - 2006-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chimeric HIV-1 and HIV-2 lentiviral vectors with added safety insurance. AN - 68374458; 17177309 AB - Lentiviruses are unique in their ability to infect both dividing and non-dividing cells. This makes the vectors derived from them particularly useful for gene transfer into non-dividing cells, including stem cells. Lentiviral vectors are becoming the vectors of choice for si/shRNA delivery. The utility of the lentiviral vectors will be enhanced if additional elements of safety are built into their design. One safety concern is the generation of replication competent virus by recombination. We reasoned that HIV-1 and HIV-2 hybrid or chimeric lentiviral vectors will have added safety insurance in this regard. This is based on the premise that HIV-1 and HIV-2 are dissimilar enough in sequence to curtail recombination, yet similar enough to complement functionally. For hybrid vectors, we found that both HIV-1 and HIV-2 transfer vector RNAs could be packaged to equivalent titer by the HIV-1 packaging machinery. However, HIV-2 packaging machinery was unable to package HIV-1 transfer vector as well as it did HIV-2 transfer vector. This non-reciprocacity suggested that the requirement for HIV-2 vectors was more stringent and that for HIV-1 vectors more promiscuous. When the HIV-1 transfer vector was packaged with the chimeric packaging construct where the leader-gag region of HIV-2 was replaced with that of HIV-1 packaging construct, the titer of the vector went up. This suggests that at least some of the determinants of specificity for vector assembly reside in the leader-gag region. Incorporation of central polypurine tract (cPPT) and woodchuck post-transcriptional enhance element (WPRE) into the HIV-2 vectors had only modest effect on vector titer. Thus, chimeric lentiviral vectors with added safety features can be designed without compromising transduction efficiency. JF - Journal of medical virology AU - Sachdeva, Geetanjali AU - D'Costa, Jenice AU - Cho, Jang E AU - Kachapati, Kritika AU - Choudhry, Vidita AU - Arya, Suresh K AD - Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 118 EP - 126 VL - 79 IS - 2 SN - 0146-6615, 0146-6615 KW - Gene Products, gag KW - 0 KW - Index Medicus KW - Virus Replication KW - Virus Assembly KW - Gene Products, gag -- genetics KW - Lentivirus -- metabolism KW - Humans KW - Enhancer Elements, Genetic KW - Lentivirus -- genetics KW - Gene Products, gag -- metabolism KW - Mutagenesis, Insertional KW - Cell Line KW - Genetic Vectors -- standards KW - HIV-1 -- metabolism KW - HIV-1 -- genetics KW - Safety KW - Recombination, Genetic KW - HIV-2 -- genetics KW - HIV-1 -- physiology KW - HIV-2 -- physiology KW - HIV-2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68374458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medical+virology&rft.atitle=Chimeric+HIV-1+and+HIV-2+lentiviral+vectors+with+added+safety+insurance.&rft.au=Sachdeva%2C+Geetanjali%3BD%27Costa%2C+Jenice%3BCho%2C+Jang+E%3BKachapati%2C+Kritika%3BChoudhry%2C+Vidita%3BArya%2C+Suresh+K&rft.aulast=Sachdeva&rft.aufirst=Geetanjali&rft.date=2007-02-01&rft.volume=79&rft.issue=2&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Journal+of+medical+virology&rft.issn=01466615&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-06 N1 - Date created - 2006-12-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Measuring the rate of gross chromosomal rearrangements in Saccharomyces cerevisiae: A practical approach to study genomic rearrangements observed in cancer. AN - 68373532; 17189859 AB - Gross chromosomal rearrangements (GCRs), including translocations, deletions, amplifications and aneuploidy are frequently observed in various types of human cancers. Despite their clear importance in carcinogenesis, the molecular mechanisms by which GCRs are generated and held in check are poorly understood. By using a GCR assay, which can measure the rate of accumulation of spontaneous GCRs in Saccharomyces cerevisiae, we have found that many proteins involved in DNA replication, DNA repair, DNA recombination, checkpoints, chromosome remodeling, and telomere maintenance, play crucial roles in GCR metabolism. We describe here the theoretical background and practical procedures of this GCR assay. We will explain the breakpoint structure and DNA damage that lead to GCR formation. We will also summarize the pathways that suppress and enhance GCR formation. Finally, we will briefly describe similar assays developed by others and discuss their potential in studying GCR metabolism. JF - Methods (San Diego, Calif.) AU - Motegi, Akira AU - Myung, Kyungjae AD - Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Bethesda, MD 20892, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 168 EP - 176 VL - 41 IS - 2 SN - 1046-2023, 1046-2023 KW - Index Medicus KW - Humans KW - Time Factors KW - Mutation KW - Saccharomyces cerevisiae -- genetics KW - Biological Assay -- methods KW - Chromosomes, Human, Pair 5 -- genetics KW - Chromosome Aberrations KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68373532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+%28San+Diego%2C+Calif.%29&rft.atitle=Measuring+the+rate+of+gross+chromosomal+rearrangements+in+Saccharomyces+cerevisiae%3A+A+practical+approach+to+study+genomic+rearrangements+observed+in+cancer.&rft.au=Motegi%2C+Akira%3BMyung%2C+Kyungjae&rft.aulast=Motegi&rft.aufirst=Akira&rft.date=2007-02-01&rft.volume=41&rft.issue=2&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=Methods+%28San+Diego%2C+Calif.%29&rft.issn=10462023&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-01 N1 - Date created - 2006-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Troponin-T and myoglobin plus echocardiographic evaluation for monitoring early cardiotoxicity of weekly epirubicin-paclitaxel in metastatic breast cancer patients. AN - 68369318; 17159609 AB - Increased serum level of troponin-T and myoglobin has been recently reported to be related to cumulative anthracycline exposure. Left ventricular ejection fraction seems accurate in monitoring systolic function according to the latest version of Toxicity Criteria by chemotherapeutics 3.0. From January 2002, 20 patients with untreated advanced breast cancer received epirubicin (25 mg/m/week) and paclitaxel (80 mg/m/week) for 24 weeks. Troponin-T, myoglobin and biochemical serum enzymes circulating levels were measured immediately before and 4 h after epirubicin administration every week. Patients underwent electrocardiography and echocardiography at weeks 0, 8, 16 and 24. The number of courses administered was 352 (median 18, range 4-24). Epirubicin median dose administered was 600 mg/m and paclitaxel median dose administered was 1760 mg/m. Troponin-T never overcame the upper normal limit; one patient experienced troponin-T elevation without any clinical or instrumental sign of cardiac failure. Myoglobin never significantly increased with the exception of a patient who underwent several abdominal fluid drainages. Creatine kinase MB and C-reactive protein never moved outside the upper normal limit. No symptomatic cardiac event was recorded. In 55 performed echocardiograms at weeks 0, 8, 16 and 24, neither left ventricular ejection fraction nor early peak flow/atrial flow velocity registered any significant decrease. No troponin-T or myoglobin serum elevations and Left ventricular ejection fraction/early peak flow/atrial flow velocity changes were registered in our series of nonsymptomatic women during epirubicin/paclitaxel weekly chemotherapy in the absence of clinical cardiac toxicity. Longer follow-up is needed, however, to understand whether the troponin-T or myoglobin circulating level measurement is able to detect subclinical, early-stage doxorubicin-induced cardiotoxicity. JF - Anti-cancer drugs AU - Nisticò, Cecilia AU - Bria, Emilio AU - Cuppone, Federica AU - Carpino, Armando AU - Ferretti, Gianluigi AU - Vitelli, Gaetano AU - Sperduti, Isabella AU - Calabretta, Francesca AU - Toglia, Giuseppe AU - Tomao, Silverio AU - Cognetti, Francesco AU - Terzoli, Edmondo AD - Department of Medical Oncology, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 227 EP - 232 VL - 18 IS - 2 SN - 0959-4973, 0959-4973 KW - Antibiotics, Antineoplastic KW - 0 KW - Antineoplastic Agents, Phytogenic KW - Myoglobin KW - Troponin T KW - Epirubicin KW - 3Z8479ZZ5X KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Paclitaxel -- administration & dosage KW - Antibiotics, Antineoplastic -- administration & dosage KW - Humans KW - Genes, erbB-2 -- genetics KW - Aged KW - Middle Aged KW - Monitoring, Physiologic KW - Epirubicin -- administration & dosage KW - Stroke Volume -- drug effects KW - Antineoplastic Agents, Phytogenic -- administration & dosage KW - Female KW - Breast Neoplasms -- drug therapy KW - Troponin T -- blood KW - Cardiovascular Diseases -- blood KW - Echocardiography KW - Cardiovascular Diseases -- chemically induced KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Myoglobin -- blood KW - Breast Neoplasms -- complications KW - Cardiovascular Diseases -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68369318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anti-cancer+drugs&rft.atitle=Troponin-T+and+myoglobin+plus+echocardiographic+evaluation+for+monitoring+early+cardiotoxicity+of+weekly+epirubicin-paclitaxel+in+metastatic+breast+cancer+patients.&rft.au=Nistic%C3%B2%2C+Cecilia%3BBria%2C+Emilio%3BCuppone%2C+Federica%3BCarpino%2C+Armando%3BFerretti%2C+Gianluigi%3BVitelli%2C+Gaetano%3BSperduti%2C+Isabella%3BCalabretta%2C+Francesca%3BToglia%2C+Giuseppe%3BTomao%2C+Silverio%3BCognetti%2C+Francesco%3BTerzoli%2C+Edmondo&rft.aulast=Nistic%C3%B2&rft.aufirst=Cecilia&rft.date=2007-02-01&rft.volume=18&rft.issue=2&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Anti-cancer+drugs&rft.issn=09594973&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-06 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Risk factors for intrahepatic cholangiocarcinoma in a low-risk population: a nationwide case-control study. AN - 68368682; 17109384 AB - Recently, the incidence of intrahepatic cholangiocarcinoma (ICC) has been increasing in a number of developed (Western) countries. However, risk factors in these low-risk populations are poorly understood. In this nationwide population based case-control study in Denmark, we examined the relationship between selected medical conditions and subsequent ICC risk to provide additional clues to etiopathogenesis. All histologically confirmed ICC cases diagnosed in Denmark between 1978 and 1991 were identified from the Danish cancer registry. Population controls were selected from the central population registry and were matched 4:1 to cases on sex and year of birth. Cases and controls were linked to the Danish hospital discharge registry to obtain information on prior hospital diagnoses. Odds ratios (OR) and 95% confidence intervals (95% CI) were derived using conditional logistic regression. A total of 764 ICC cases and 3,056 population controls were included in the study. Chronic liver diseases were significantly related to ICC: alcoholic liver disease (OR = 19.22, 95% CI = 5.55-66.54), unspecified cirrhosis (OR = 75.9, 95% CI 10.2-565.7). Bile duct diseases were also associated with risk: cholangitis (OR = 6.3, 95% CI = 2.3-17.5), choledocholithiasis (OR = 23.97, 95% CI = 2.9-198.9), cholecystolithiasis (OR = 4.0, 95% CI = 2.0-7.99), though gallbladder removal did not change risk (OR = 1.6, 95% CI = 0.65-3.7). Among other conditions, chronic inflammatory bowel disease (OR = 4.7, 95% CI = 1.65-13.9) was significantly associated with ICC. Diabetes was associated with risk in the year prior to diagnosis of ICC (OR = 3.02, 95% CI = 1.05-8.69). Obesity was unrelated to risk. These results confirm that prior bile duct diseases increase risk of ICC and suggest that alcoholic liver disease and diabetes may also increase risk. JF - International journal of cancer AU - Welzel, Tania M AU - Mellemkjaer, Lene AU - Gloria, Gridley AU - Sakoda, Lori C AU - Hsing, Ann W AU - El Ghormli, Laure AU - Olsen, Jorgen H AU - McGlynn, Katherine A AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7234, USA. welzlt@mail.nih.gov Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 638 EP - 641 VL - 120 IS - 3 SN - 0020-7136, 0020-7136 KW - Index Medicus KW - Choledocholithiasis -- complications KW - Odds Ratio KW - Registries -- statistics & numerical data KW - Humans KW - Aged KW - Cholecystolithiasis -- complications KW - Liver Cirrhosis -- complications KW - Cholangitis -- complications KW - Inflammatory Bowel Diseases -- complications KW - Logistic Models KW - Risk Factors KW - Case-Control Studies KW - Denmark -- epidemiology KW - Incidence KW - Middle Aged KW - Liver Diseases, Alcoholic -- complications KW - Male KW - Female KW - Bile Duct Neoplasms -- epidemiology KW - Liver Diseases -- complications KW - Bile Ducts, Intrahepatic KW - Cholangiocarcinoma -- etiology KW - Cholangiocarcinoma -- epidemiology KW - Bile Duct Neoplasms -- etiology KW - Bile Duct Diseases -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68368682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Risk+factors+for+intrahepatic+cholangiocarcinoma+in+a+low-risk+population%3A+a+nationwide+case-control+study.&rft.au=Welzel%2C+Tania+M%3BMellemkjaer%2C+Lene%3BGloria%2C+Gridley%3BSakoda%2C+Lori+C%3BHsing%2C+Ann+W%3BEl+Ghormli%2C+Laure%3BOlsen%2C+Jorgen+H%3BMcGlynn%2C+Katherine+A&rft.aulast=Welzel&rft.aufirst=Tania&rft.date=2007-02-01&rft.volume=120&rft.issue=3&rft.spage=638&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-05 N1 - Date created - 2006-12-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - TGFbeta1 and TGFalpha contrarily affect alveolar survival and tumorigenesis in mouse mammary epithelium. AN - 68368566; 17096338 AB - Growth factors and hormones are responsible for development of the mammary gland and can contribute to mammary carcinogenesis. The transforming growth factors (TGF) alpha and beta1 demonstrate opposing effects on the mammary epithelium. TGFalpha is a mitogen and survival factor for mammary secretory cells and is often upregulated in cancer, while TGFbeta1 may act as a growth suppressor and has been shown to inhibit alveolar development and lactogenesis. To examine the contradistinct effects of TGFalpha and TGFbeta1 on normal mammary epithelium, we crossed MT-TGFalpha mice with WAP-TGFbeta1 transgenic mice. The newly generated bitransgenic mice failed to nurse their pups and were resistant to mammary tumorigenesis (0% at 12 months of age), compared to single transgenic MT-TGFalpha in which the majority (65% at 12 months of age) of the mice developed hyperplastic alveolar mammary lesions. Transplantation studies showed that bitransgenic tissue was highly resistant to tumor formation even after multiple pregnancies. WAP-TGFbeta1 mammary transplants often failed to grow and fully fill cleared mammary fat pads upon transplantation. This repression of growth was completely reversed in the bitransgenic implants, which grew as well as normal epithelium upon transplantation. In addition, TGF and bitransgenic TGFalpha/TGFbeta1 mice had reduced rates of apoptosis during involution as compared to wild type and TGFbeta1. These data demonstrate that TGFbeta1 and TGFalpha exhibit opposing effects upon the proliferation and survival of mammary epithelium when expressed alone but when expressed together result in reciprocally suppressive effects upon one another in the context of mammary development and tumorigenesis. JF - International journal of cancer AU - Booth, Brian W AU - Jhappan, Chamelli AU - Merlino, Glenn AU - Smith, Gilbert H AD - Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, National Institute of Health, Bethesda, MD, USA. Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 493 EP - 499 VL - 120 IS - 3 SN - 0020-7136, 0020-7136 KW - Proliferating Cell Nuclear Antigen KW - 0 KW - Transforming Growth Factor alpha KW - Transforming Growth Factor beta1 KW - Index Medicus KW - Animals KW - Apoptosis KW - Humans KW - Proliferating Cell Nuclear Antigen -- analysis KW - Mice KW - Precancerous Conditions -- metabolism KW - Mice, Transgenic KW - Precancerous Conditions -- pathology KW - Cell Survival KW - Phenotype KW - Genotype KW - Mice, Inbred Strains KW - Precancerous Conditions -- genetics KW - Epithelium -- metabolism KW - Epithelium -- pathology KW - Immunohistochemistry KW - Female KW - Male KW - Transforming Growth Factor alpha -- genetics KW - Mammary Glands, Animal -- metabolism KW - Mammary Glands, Animal -- pathology KW - Mammary Neoplasms, Experimental -- genetics KW - Transforming Growth Factor beta1 -- genetics KW - Mammary Neoplasms, Experimental -- metabolism KW - Mammary Neoplasms, Experimental -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68368566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=TGFbeta1+and+TGFalpha+contrarily+affect+alveolar+survival+and+tumorigenesis+in+mouse+mammary+epithelium.&rft.au=Booth%2C+Brian+W%3BJhappan%2C+Chamelli%3BMerlino%2C+Glenn%3BSmith%2C+Gilbert+H&rft.aulast=Booth&rft.aufirst=Brian&rft.date=2007-02-01&rft.volume=120&rft.issue=3&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-05 N1 - Date created - 2006-12-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phase II trial of ixabepilone, an epothilone B analog, given daily for three days every three weeks, in metastatic breast cancer. AN - 68366223; 16933153 AB - Twelve patients with metastatic breast cancer previously exposed to taxanes were treated on a Phase II trial with ixabepilone. Eligible patients had histologically confirmed metastatic breast cancer with measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST), and adequate hematopoietic, renal, and hepatic function. Ixabepilone 8 mg/m(2)/day was given intravenously daily for 3 days for the first 3-week cycle and increased to 10 mg/m(2)/day for subsequent cycles if patients did not have hematologic or other toxicity after the first cycle. Patients continued treatment until progressive disease or unacceptable toxicity. Three, 29, and 33 of 65 cycles administered were at the 7 mg/m(2), 8 mg/m(2) and 10 mg/m(2) dose levels respectively. Grade 4 leukopenia (n=1), grade 3 neutropenia (n=2), grade 2 neuropathy (n=3), and grade 2 transaminase elevation (n=2) were the most notable toxicities. Ten patients had stable disease for at least 6 weeks. No complete or partial responses were observed in 12 evaluable patients treated with ixabepilone daily for 3 days. Although ixabepilone was well-tolerated, the dose of 8-10 mg/m(2) daily for 3 days is not an effective therapy in metastatic breast cancer previously exposed to taxanes. JF - Investigational new drugs AU - Denduluri, Neelima AU - Lee, James J AU - Walshe, Janice AU - Berman, Arlene W AU - Vatas, Ujala AU - Chow, Catherine K AU - Steinberg, Seth M AU - Cox, Michael C AU - Low, Jennifer A AU - Swain, Sandra M AD - Breast Cancer Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Heath, Bldg 8, Rm 5101, 8901 Wisconsin Ave, Bethesda, MD 20889-5015, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 63 EP - 67 VL - 25 IS - 1 SN - 0167-6997, 0167-6997 KW - Epothilones KW - 0 KW - Tubulin Modulators KW - Transaminases KW - EC 2.6.1.- KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - ixabepilone KW - K27005NP0A KW - epothilone B KW - UEC0H0URSE KW - Index Medicus KW - Drug Administration Schedule KW - Injections, Intravenous KW - Humans KW - Disease Progression KW - Peripheral Nervous System Diseases -- chemically induced KW - Tubulin Modulators -- administration & dosage KW - Transaminases -- blood KW - Aspartate Aminotransferases -- blood KW - Hematologic Diseases -- chemically induced KW - Tubulin Modulators -- adverse effects KW - Adult KW - Tubulin Modulators -- therapeutic use KW - Treatment Outcome KW - Neoplasm Metastasis KW - Middle Aged KW - Time Factors KW - Female KW - Breast Neoplasms -- drug therapy KW - Epothilones -- therapeutic use KW - Breast Neoplasms -- pathology KW - Epothilones -- adverse effects KW - Breast Neoplasms -- blood KW - Epothilones -- chemistry KW - Epothilones -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68366223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigational+new+drugs&rft.atitle=Phase+II+trial+of+ixabepilone%2C+an+epothilone+B+analog%2C+given+daily+for+three+days+every+three+weeks%2C+in+metastatic+breast+cancer.&rft.au=Denduluri%2C+Neelima%3BLee%2C+James+J%3BWalshe%2C+Janice%3BBerman%2C+Arlene+W%3BVatas%2C+Ujala%3BChow%2C+Catherine+K%3BSteinberg%2C+Seth+M%3BCox%2C+Michael+C%3BLow%2C+Jennifer+A%3BSwain%2C+Sandra+M&rft.aulast=Denduluri&rft.aufirst=Neelima&rft.date=2007-02-01&rft.volume=25&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Investigational+new+drugs&rft.issn=01676997&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-05 N1 - Date created - 2006-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Occupational exposure to organochlorine insecticides and cancer incidence in the Agricultural Health Study. AN - 68365804; 17096337 AB - Organochlorine (OC) insecticides have been regulated as possible human carcinogens primarily on the basis of animal studies. However, the epidemiologic evidence is inconsistent. We investigated the relationship between cancer incidence and OC insecticide use among pesticide applicators enrolled in the Agricultural Health Study, a prospective cohort study of 57,311 licensed applicators in Iowa and North Carolina enrolled between 1993 and 1997. Information on ever use of 7 OC insecticides (aldrin, chlordane, DDT, dieldrin, heptachlor, lindane, toxaphene) was collected from a self-administered questionnaire at enrollment. Lifetime exposure-days to OC insecticides were calculated using additional data from a take-home questionnaire completed by 25,291 participants (44% of total). We found no clear evidence of an association between use of OC insecticides and incident cancers (N = 1,150) ascertained through December, 2002. When we focused on individual insecticides and structurally similar groups (aldrin and dieldrin; chlordane and heptachlor), significantly increased relative risks of some cancers were observed for use of some chemicals (rectal cancer and chlordane, lung cancer and dieldrin, non-Hodgkin lymphoma (NHL) and lindane, melanoma and toxaphene, leukemia and chlordane/heptachlor). Some significant decreased relative risks were also observed (colon cancer and aldrin; overall cancer and heptachlor). In conclusion, we did not observe any clear relationship between cancer risk and the use of OC insecticides. Our chemical-specific findings are based on small numbers and multiple comparisons, and should be interpreted with caution; however, some observed associations (lindane and NHL, chlordane/heptachlor and leukemia) are supported by previous evidence. JF - International journal of cancer AU - Purdue, Mark P AU - Hoppin, Jane A AU - Blair, Aaron AU - Dosemeci, Mustafa AU - Alavanja, Michael C R AD - Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA. purduem@mail.nih.gov Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 642 EP - 649 VL - 120 IS - 3 SN - 0020-7136, 0020-7136 KW - Hydrocarbons, Chlorinated KW - 0 KW - Insecticides KW - Chlordan KW - 12789-03-6 KW - Heptachlor KW - 7GLS9ACN3L KW - Dieldrin KW - I0246D2ZS0 KW - Aldrin KW - OZE3CLY605 KW - Index Medicus KW - Heptachlor -- poisoning KW - Humans KW - Aged KW - North Carolina -- epidemiology KW - Environmental Pollution -- adverse effects KW - Prospective Studies KW - Aldrin -- poisoning KW - Chlordan -- poisoning KW - Adult KW - Surveys and Questionnaires KW - Dieldrin -- poisoning KW - Incidence KW - Middle Aged KW - Male KW - Environmental Pollution -- analysis KW - Female KW - Iowa -- epidemiology KW - Insecticides -- poisoning KW - Hydrocarbons, Chlorinated -- poisoning KW - Agricultural Workers' Diseases -- etiology KW - Agricultural Workers' Diseases -- epidemiology KW - Neoplasms -- epidemiology KW - Occupational Exposure -- adverse effects KW - Occupational Exposure -- analysis KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68365804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Occupational+exposure+to+organochlorine+insecticides+and+cancer+incidence+in+the+Agricultural+Health+Study.&rft.au=Purdue%2C+Mark+P%3BHoppin%2C+Jane+A%3BBlair%2C+Aaron%3BDosemeci%2C+Mustafa%3BAlavanja%2C+Michael+C+R&rft.aulast=Purdue&rft.aufirst=Mark&rft.date=2007-02-01&rft.volume=120&rft.issue=3&rft.spage=642&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-05 N1 - Date created - 2006-12-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 1990 Oct 15;50(20):6585-91 [2208120] Cancer Epidemiol Biomarkers Prev. 2000 Feb;9(2):199-205 [10698482] Cancer Epidemiol Biomarkers Prev. 2001 Nov;10(11):1155-63 [11700263] Epidemiology. 2002 Jan;13(1):94-9 [11805592] Int J Occup Med Environ Health. 2001;14(4):339-47 [11885917] Ann Occup Hyg. 2002 Mar;46(2):245-60 [12074034] J Expo Anal Environ Epidemiol. 2002 Sep;12(5):313-8 [12198579] CA Cancer J Clin. 2002 Sep-Oct;52(5):301-9 [12363327] Environ Health Perspect. 2003 Feb;111(2):179-83 [12573902] Am J Epidemiol. 2003 Apr 15;157(8):683-91 [12697572] Am J Epidemiol. 2003 May 1;157(9):800-14 [12727674] J Natl Cancer Inst. 1992 May 20;84(10):764-71 [1573662] Int J Cancer. 1993 Mar 12;53(5):740-5 [8449597] Cancer Causes Control. 1994 Sep;5(5):449-57 [7999967] Nature. 1995 Jun 15;375(6532):581-5 [7791873] Environ Health Perspect. 1995 Oct;103 Suppl 7:113-22 [8593856] Environ Health Perspect. 1996 Apr;104(4):362-9 [8732939] Int J Epidemiol. 1996 Dec;25(6):1117-24 [9027514] Am J Ind Med. 1997 Feb;31(2):233-42 [9028440] Occup Environ Med. 1997 Oct;54(10):702-7 [9404316] Am J Ind Med. 1998 Jan;33(1):82-7 [9408531] Cancer Causes Control. 1997 May;8(3):420-43 [9498903] Crit Rev Toxicol. 1998 Mar;28(2):109-227 [9557209] Cancer Causes Control. 1998 May;9(3):311-9 [9684711] Toxicology. 1998 Jun 26;128(1):17-23 [9704902] Environ Res. 2005 May;98(1):104-13 [15721890] Cancer Res. 2005 Oct 15;65(20):9588-94 [16230425] J Occup Environ Med. 2003 Jul;45(7):692-702 [12855910] Toxicol Ind Health. 2002 Mar;18(2):63-70 [12868794] Chemosphere. 2004 Mar;54(10):1509-20 [14659953] Am J Epidemiol. 2004 Nov 1;160(9):876-85 [15496540] Tsitol Genet. 1974 Jan-Feb;8(1):24-7 [4829676] J Hered. 1976 Sep-Oct;67(5):303-7 [1010933] Scand J Work Environ Health. 1978 Jun;4(2):137-50 [278225] Int Arch Occup Environ Health. 1985;56(2):75-9 [4055072] Scand J Work Environ Health. 1985 Dec;11(6):397-407 [3912986] Teratog Carcinog Mutagen. 1987;7(6):527-40 [2893466] IARC Monogr Eval Carcinog Risks Hum Suppl. 1987;7:1-440 [3482203] Hum Genet. 1989 Oct;83(3):271-3 [2477324] Cancer. 1989 Dec 1;64(11):2381-6 [2804930] Int J Epidemiol. 1989 Dec;18(4):768-74 [2621012] Toxicology. 1991;70(3):283-92 [1771636] Cancer Res. 1992 May 1;52(9):2447-55 [1568215] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toward individualized treatment: prediction of anticancer drug disposition and toxicity with pharmacogenetics. AN - 68365310; 17159598 AB - A great deal of effort has been spent in defining the pharmacokinetics and pharmacodynamics of investigational and registered anticancer agents. Often, there is a marked variability in drug handling between individual patients, which contributes to variability in the pharmacodynamic effects of a given dose of a drug. A combination of physiological variables, genetic characteristics (pharmacogenetics) and environmental factors is known to alter the relationship between the absolute dose and the concentration-time profile in plasma. A variety of strategies are now being evaluated in patients with cancer to improve the therapeutic index of anticancer drugs by implementation of pharmacogenetic imprinting through genotyping or phenotyping individual patients. The efforts have mainly focused on variants in genes encoding the drug-metabolizing enzymes thiopurine S-methyltransferase, dihydropyrimidine dehydrogenase, members of the cytochrome P450 family, including the CYP2B, 2C, 2D and 3A subfamilies, members of the UDP glucuronosyltransferase family, as well as the ATP-binding cassette transporters ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein). Several of these genotyping strategies have been shown to have substantial impact on therapeutic outcome and should eventually lead to improved anticancer chemotherapy. JF - Anti-cancer drugs AU - Deeken, John F AU - Figg, William D AU - Bates, Susan E AU - Sparreboom, Alex AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20895, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 111 EP - 126 VL - 18 IS - 2 SN - 0959-4973, 0959-4973 KW - Antineoplastic Agents KW - 0 KW - Carrier Proteins KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Animals KW - Carrier Proteins -- metabolism KW - Cytochrome P-450 Enzyme System -- genetics KW - Humans KW - Carrier Proteins -- genetics KW - Cytochrome P-450 Enzyme System -- metabolism KW - Predictive Value of Tests KW - Neoplasms -- drug therapy KW - Antineoplastic Agents -- pharmacokinetics KW - Antineoplastic Agents -- therapeutic use KW - Pharmacogenetics KW - Neoplasms -- genetics KW - Neoplasms -- metabolism KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68365310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anti-cancer+drugs&rft.atitle=Toward+individualized+treatment%3A+prediction+of+anticancer+drug+disposition+and+toxicity+with+pharmacogenetics.&rft.au=Deeken%2C+John+F%3BFigg%2C+William+D%3BBates%2C+Susan+E%3BSparreboom%2C+Alex&rft.aulast=Deeken&rft.aufirst=John&rft.date=2007-02-01&rft.volume=18&rft.issue=2&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Anti-cancer+drugs&rft.issn=09594973&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-06 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Defined by Publication: A Commentary on Health Education and Health Promotion Publication Trends AN - 57196193; 200714265 AB - Comments on Ray M. Merrill et al's "Have the Focus and Sophistication of Research in Health Education Changed?" (2007). Attention is given to quantitative & qualitative research in the field & explanations for the publication growth of quantitative but not qualitative research. References. [Reprinted by permission of Sage Publications Inc., copyright 2007, Society for Public Health Education.] JF - Health Education & Behavior AU - Simons-Morton, Bruce AD - Prevention Research Branch, DESPR, NICHD, NIH, Bethesda, MD Mortonb@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 26 EP - 30 PB - Sage Publications, Thousand Oaks CA VL - 34 IS - 1 SN - 1090-1981, 1090-1981 KW - research design KW - statistical methods KW - surveys KW - Health care KW - Periodicals KW - Health education KW - Statistical analysis KW - Research design KW - Publications KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57196193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Education+%26+Behavior&rft.atitle=Defined+by+Publication%3A+A+Commentary+on+Health+Education+and+Health+Promotion+Publication+Trends&rft.au=Simons-Morton%2C+Bruce&rft.aulast=Simons-Morton&rft.aufirst=Bruce&rft.date=2007-02-01&rft.volume=34&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Health+Education+%26+Behavior&rft.issn=10901981&rft_id=info:doi/10.1177%2F1090198106288567 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-07-31 N1 - Last updated - 2016-09-27 N1 - CODEN - HEDBFS N1 - SubjectsTermNotLitGenreText - Research design; Statistical analysis; Health education; Health care; Publications; Periodicals DO - http://dx.doi.org/10.1177/1090198106288567 ER - TY - CPAPER T1 - Impairment of Treg-Specific Foxp3 Expression by Virus-Induced Dysregulation of TGF-beta Signaling T2 - 2007 Keystone Symposia on Regulatory T Cells (B3) AN - 40538048; 4516943 JF - 2007 Keystone Symposia on Regulatory T Cells (B3) AU - Grant, Christian W Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 KW - Signal transduction KW - Foxp3 protein KW - Transforming growth factor-b KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40538048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Regulatory+T+Cells+%28B3%29&rft.atitle=Impairment+of+Treg-Specific+Foxp3+Expression+by+Virus-Induced+Dysregulation+of+TGF-beta+Signaling&rft.au=Grant%2C+Christian+W&rft.aulast=Grant&rft.aufirst=Christian&rft.date=2007-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Regulatory+T+Cells+%28B3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 9&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tissue Specific Localization of Virus-Induced Regulatory T Cells Correlates with CD8+ T Cell Dysfunction T2 - 2007 Keystone Symposia on Regulatory T Cells (B3) AN - 40523847; 4516958 JF - 2007 Keystone Symposia on Regulatory T Cells (B3) AU - Myers, Lara M Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 KW - Lymphocytes T KW - CD8 antigen KW - Immunoregulation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40523847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Regulatory+T+Cells+%28B3%29&rft.atitle=Tissue+Specific+Localization+of+Virus-Induced+Regulatory+T+Cells+Correlates+with+CD8%2B+T+Cell+Dysfunction&rft.au=Myers%2C+Lara+M&rft.aulast=Myers&rft.aufirst=Lara&rft.date=2007-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Regulatory+T+Cells+%28B3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 9&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enabling the CTL Response in the Presence of Virus-Induced Regulatory T Cells T2 - 2007 Keystone Symposia on Regulatory T Cells (B3) AN - 40523692; 4516968 JF - 2007 Keystone Symposia on Regulatory T Cells (B3) AU - Hasenkrug, Kim J Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 KW - Lymphocytes T KW - Cytotoxicity KW - Immunoregulation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40523692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Regulatory+T+Cells+%28B3%29&rft.atitle=Enabling+the+CTL+Response+in+the+Presence+of+Virus-Induced+Regulatory+T+Cells&rft.au=Hasenkrug%2C+Kim+J&rft.aulast=Hasenkrug&rft.aufirst=Kim&rft.date=2007-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Regulatory+T+Cells+%28B3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 9&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Antigen Specificity and Origin of Foxp3+Treg during Parasitic Infections T2 - 2007 Keystone Symposia on Regulatory T Cells (B3) AN - 40522751; 4516967 JF - 2007 Keystone Symposia on Regulatory T Cells (B3) AU - Belkaid, Yasmine Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 KW - Infection KW - Antigens KW - Specificity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40522751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Regulatory+T+Cells+%28B3%29&rft.atitle=Antigen+Specificity+and+Origin+of+Foxp3%2BTreg+during+Parasitic+Infections&rft.au=Belkaid%2C+Yasmine&rft.aulast=Belkaid&rft.aufirst=Yasmine&rft.date=2007-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Regulatory+T+Cells+%28B3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 9&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanisms of Action of T Regulatory Cells In Vivo T2 - 2007 Keystone Symposia on Regulatory T Cells (B3) AN - 40522503; 4516949 JF - 2007 Keystone Symposia on Regulatory T Cells (B3) AU - Shevach, Ethan M Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 KW - Lymphocytes T KW - Immunoregulation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40522503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Regulatory+T+Cells+%28B3%29&rft.atitle=Mechanisms+of+Action+of+T+Regulatory+Cells+In+Vivo&rft.au=Shevach%2C+Ethan+M&rft.aulast=Shevach&rft.aufirst=Ethan&rft.date=2007-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Regulatory+T+Cells+%28B3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 9&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Substance use and sexual behaviors among Japanese tourists, students, and temporary workers in Honolulu, Hawaii AN - 36704183; 3444908 AB - A total of 249 Japanese nationals-tourists (n = 107), students (n = 98), and temporary workers (n = 44)-were recruited at the targeted community venues in Honolulu, Hawaii, and completed a structured survey questionnaire. Reported lifetime sexually transmitted diseases, or STDs infection (10% male and 20% female participants), and HIV infection rates (7%, 2 out of 31 persons tested) were high. Male participants were more likely to practice safe sex with female sex workers than with steady and casual female partners both in Japan and Hawaii. More than 80% of the participants reported having had sex under the influence of alcohol. Multivariate analysis revealed that positive attitudes toward drug use and negative attitudes toward condom use were significantly correlated with the frequency of sex under the influence of drugs with steady partners in the past 12 months. Future HIV/STD prevention intervention programs must target Japanese youths who are planning to visit Hawaii or elsewhere abroad, as well as Japanese high-risk groups (e.g., temporary workers in Hawaii), and provide information about HIV/STD prevention in relation to substance use. Reprinted by permission of Guilford Publications Inc., New York City JF - AIDS education and prevention AU - Nemoto, Tooru AU - Iwamoto, Mariko AU - Morris, Anne AU - Yokota, Fumihiko AU - Wada, Kiyoshi AD - University of California, San Francisco ; Tulane University ; National Institute of Mental Health, Japan Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 68 EP - 81 VL - 19 IS - 1 SN - 0899-9546, 0899-9546 KW - Sociology KW - Tourism KW - Japanese KW - Attitudes KW - Sexual behaviour KW - Multivariate analysis KW - Hawaii KW - HIV KW - Students KW - Substance use KW - Sexually transmitted diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36704183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+education+and+prevention&rft.atitle=Substance+use+and+sexual+behaviors+among+Japanese+tourists%2C+students%2C+and+temporary+workers+in+Honolulu%2C+Hawaii&rft.au=Nemoto%2C+Tooru%3BIwamoto%2C+Mariko%3BMorris%2C+Anne%3BYokota%2C+Fumihiko%3BWada%2C+Kiyoshi&rft.aulast=Nemoto&rft.aufirst=Tooru&rft.date=2007-02-01&rft.volume=19&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=AIDS+education+and+prevention&rft.issn=08999546&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12357; 11563 1025 1542 11325 6071; 6946 1335 4424; 12794 7336 3198; 12334 4049; 11581 3617 6220; 5703 3617 6220; 8379 12224 971; 1378 10404; 164 433 293 14 ER - TY - JOUR T1 - Symptom management and self-care for peripheral neuropathy in HIV/AIDS AN - 36664301; 3425050 AB - Peripheral neuropathy is the most common neurological complication in HIV and is often associated with antiretroviral therapy. As part of a larger study on self-care for symptoms in HIV disease, this study analyzed the prevalence and characteristics of peripheral neuropathy in HIV disease, sociodemographic and disease-related correlates and self-care strategies. A convenience sample of 1,217 respondents was recruited from data collection sites in several US cities, Puerto Rico, Colombia and Taiwan. Results of the study indicated that respondents with peripheral neuropathy (n =450) identified 20 self-care behaviors including complementary therapies, use of medications, exercise and rest and/or elevation of extremities. Ratings of frequency and effectiveness were also included. An activities checklist summarized into five categories of self-care behaviors including activities/thoughts, exercise, medications, complementary therapies and substance was used to determine self-care behaviors. Taking a hot bath was the most frequent strategy used by those with peripheral neuropathy (n =292) and received the highest overall rating of effectiveness of any self-management strategies included in this study at 8.1 (scale 1-10). Other self-care strategies to manage this symptom included: staying off the feet (n = 258), rubbing the feet with cream (n = 177), elevating the feet (n = 236), walking (n = 262), prescribed anti-epileptic agent (n = 80), prescribed analgesics (n = 84), over-the-counter medications (n = 123), vitamin B (n = 122), calcium supplements (n = 72), magnesium (n =48), massage (n = 156), acupuncture (n = 43), reflexology (n = 23 and meditation (n = 80). Several behaviors that are often deemed unhealthy were included among the strategies reported to alleviate peripheral neuropathy including use of marijuana (n = 67), cigarette smoking (n = 139), drinking alcohol (n = 81) and street drugs (n = 30). Reprinted by permission of Routledge, Taylor & Francis Ltd. JF - AIDS care AU - Nicholas, P K AU - Kemppainen, J K AU - Canaval, G E AU - Corless, I B AU - Sefcik, E F AU - Nokes, K M AU - Bain, C A AU - Kirksey, K M AU - Eller, L Sanzero AU - Dole, P J AU - Hamilton, M J AU - Coleman, C L AU - Holzemer, W L AU - Reynolds, N R AU - Portillo, C J AU - Bunch, E H AU - Wantland, D J AU - Voss, J AU - Phillips, R AU - Tsai, Y F AU - Mendez, M Rivero AU - Lindgren, T G AU - Davis, S M AU - Gallagher, D M AD - Brigham and Women's Hospital, Boston ; University of North Carolina ; Universidad del Valle ; Texas A&M University ; City University of New York ; University of California ; Ben Taub General Hospital, Houston ; Rutgers University ; Greenwich House, New York City ; University of Pennsylvania ; Ohio State University ; University of Oslo ; National Institutes of Health, Bethesda ; Chang Gung University ; Universidad de Puerto Rico ; Massachusetts General Hospital, Boston ; New England AIDS Education and Training Center, Boston Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 179 EP - 189 VL - 19 IS - 2 SN - 0954-0121, 0954-0121 KW - Sociology KW - Medical sociology KW - AIDS KW - Health KW - Medical treatment KW - Diseases KW - HIV KW - Neurology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36664301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+care&rft.atitle=Symptom+management+and+self-care+for+peripheral+neuropathy+in+HIV%2FAIDS&rft.au=Nicholas%2C+P+K%3BKemppainen%2C+J+K%3BCanaval%2C+G+E%3BCorless%2C+I+B%3BSefcik%2C+E+F%3BNokes%2C+K+M%3BBain%2C+C+A%3BKirksey%2C+K+M%3BEller%2C+L+Sanzero%3BDole%2C+P+J%3BHamilton%2C+M+J%3BColeman%2C+C+L%3BHolzemer%2C+W+L%3BReynolds%2C+N+R%3BPortillo%2C+C+J%3BBunch%2C+E+H%3BWantland%2C+D+J%3BVoss%2C+J%3BPhillips%2C+R%3BTsai%2C+Y+F%3BMendez%2C+M+Rivero%3BLindgren%2C+T+G%3BDavis%2C+S+M%3BGallagher%2C+D+M&rft.aulast=Nicholas&rft.aufirst=P&rft.date=2007-02-01&rft.volume=19&rft.issue=2&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=AIDS+care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540120600971083 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 7887 12008; 3617 6220; 8635; 7890 5792 10484; 5703 3617 6220; 482 3617 6220; 5772 DO - http://dx.doi.org/10.1080/09540120600971083 ER - TY - JOUR T1 - Innovative approaches to cohort retention in a community-based HIV/STI prevention trial for socially marginalized Peruvian young adults AN - 220283242; 17327244 AB - Background The conduct of longitudinal clinical trials must involve effective strategies to retain study participants in order to ensure internal validity, adequate statistical power and generalizability of results. Purpose In a large trial in Peru, we implemented various retention strategies to maintain high participation rates over time. Methods Novel participant retention strategies were used to follow highly marginalized populations for two years because traditional locator information, such as telephone numbers and official identification (eg, passport, driver's license, the local equivalent of a social security number) were often unreliable or unavailable. These strategies included detailed preliminary ethnographic research to identify the behaviours of key target groups, approaches to develop strong informal bonds between project staff and participants outside of study settings, and methods to enhance positive participant attitudes towards the study. Results The overall study retention rate after two years was 84%, even though only 26% of the study populations supplied complete locator information (telephone, address and the names of two friends). Limitations The retention strategies used were labour intensive and iterative, which could prove difficult to replicate. Conclusions The two-year retention rate in this study was sufficient to maintain required sample sizes. The methods used to maintain contact with the populations were labour intensive, low tech and adequate for these populations and could be used to retain study participants in other marginalized, urban, low-income areas. [PUBLICATION ABSTRACT] JF - Clinical Trials AU - Villacorta, Victoria AU - Kegeles, Susan AU - Galea, Jerome AU - Konda, Kelika A AU - José Pajuelo Cuba AU - Cáceres Palacios, Carlos F AU - Coates, Thomas J Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 32 EP - 41 CY - London PB - Sage Publications Ltd. VL - 4 IS - 1 SN - 17407745 KW - Medical Sciences--Experimental Medicine, Laboratory Technique KW - Clinical trials KW - Human immunodeficiency virus KW - HIV KW - Research methodology KW - Sexually transmitted diseases KW - STD KW - Young adults KW - Socioeconomic factors KW - Peru KW - Age Factors KW - Humans KW - Adult KW - Sample Size KW - Adolescent KW - Male KW - Female KW - Anthropology, Cultural KW - HIV Infections -- prevention & control KW - Clinical Trials as Topic KW - Research Subjects KW - Sexually Transmitted Diseases -- prevention & control KW - Residence Characteristics KW - Patient Selection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/220283242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Trials&rft.atitle=Innovative+approaches+to+cohort+retention+in+a+community-based+HIV%2FSTI+prevention+trial+for+socially+marginalized+Peruvian+young+adults&rft.au=Villacorta%2C+Victoria%3BKegeles%2C+Susan%3BGalea%2C+Jerome%3BKonda%2C+Kelika+A%3BJos%C3%A9+Pajuelo+Cuba%3BC%C3%A1ceres+Palacios%2C+Carlos+F%3BCoates%2C+Thomas+J&rft.aulast=Villacorta&rft.aufirst=Victoria&rft.date=2007-02-01&rft.volume=4&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Clinical+Trials&rft.issn=17407745&rft_id=info:doi/10.1177%2F1740774506075869 LA - English DB - ProQuest Central N1 - Copyright - SAGE Publications © Feb 2007 N1 - Last updated - 2016-06-25 N1 - SubjectsTermNotLitGenreText - Peru DO - http://dx.doi.org/10.1177/1740774506075869 ER - TY - JOUR T1 - Making the prices of new drugs fairer AN - 21284059; 7286586 JF - British Medical Journal AU - Sotelo, Julio AD - National Institutes of Health of Mexico, Mexico City Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 369 PB - British Medical Association, BMA House Square Tavistock Square London WC1H 9JP UK, [mailto:info.web@bma.org.uk], [URL:http://www.bma.org.uk/] VL - 334 IS - 7589 SN - 0959-8138, 0959-8138 KW - Biotechnology and Bioengineering Abstracts KW - Drugs KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21284059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Medical+Journal&rft.atitle=Making+the+prices+of+new+drugs+fairer&rft.au=Sotelo%2C+Julio&rft.aulast=Sotelo&rft.aufirst=Julio&rft.date=2007-02-01&rft.volume=334&rft.issue=7589&rft.spage=369&rft.isbn=&rft.btitle=&rft.title=British+Medical+Journal&rft.issn=09598138&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Drugs ER - TY - JOUR T1 - Phase II studies of anticancer chemotherapy: indirect evidence of poor quality AN - 21279599; 7286056 JF - Annals of Oncology AU - Ottaiano, A AU - Facchini, G AU - Nasti, G AU - Budillon, A AU - Caraglia, M AD - Clinical Immunology Unit. B Medical Oncology Unit. Experimental Pharmacology Unit, National Cancer Institute Fondazione 'G. Pascale', Naples, Italy Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 403 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 18 IS - 2 SN - 0923-7534, 0923-7534 KW - Biotechnology and Bioengineering Abstracts KW - Chemotherapy KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21279599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Oncology&rft.atitle=Phase+II+studies+of+anticancer+chemotherapy%3A+indirect+evidence+of+poor+quality&rft.au=Ottaiano%2C+A%3BFacchini%2C+G%3BNasti%2C+G%3BBudillon%2C+A%3BCaraglia%2C+M&rft.aulast=Ottaiano&rft.aufirst=A&rft.date=2007-02-01&rft.volume=18&rft.issue=2&rft.spage=403&rft.isbn=&rft.btitle=&rft.title=Annals+of+Oncology&rft.issn=09237534&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Chemotherapy ER - TY - JOUR T1 - A High-Throughput Cell-Based Assay to Identify Specific Inhibitors of Transcription Factor AP-1 AN - 21201307; 11617331 AB - The oncogenic transcription factor AP-1 (activator protein-1) is required for tumor promotion and progression. Identification of novel and specific AP-1 inhibitors would be beneficial for cancer prevention and therapy. The authors have developed a high-throughput assay to screen synthetic and natural product libraries for noncytotoxic inhibitors of mitogen-activated AP-1 activity. The cell-based high-throughput screen is conducted in a 384-well format using a fluorescent resonance energy transfer (FRET) substrate to quantify the activity of a b-lactamase reporter under the control of an AP-1-dependent promoter. The ratiometric FRET readout makes this assay extremely robust and reproducible, particularly for use with natural product extracts. To eliminate false positives due to cell killing, a cytotoxicity assay was incorporated. The AP-1 b-lactamase reporter was validated with inhibitors of kinases located upstream of AP-1 and with known natural product inhibitors of AP-1 (nordihydroguaiaretic acid and curcumin). The assay was able to identify other known AP-1 inhibitors and protein kinase C modulators, as well as a number of chemically diverse compounds with unknown mechanisms of action from natural products libraries. Application to natural product extracts identified hits from a range of taxonomic groups. Screening of synthetic compounds and natural products should identify novel AP-1 inhibitors that may be useful in the prevention and treatment of cancers. JF - Journal of Biomolecular Screening AU - Ruocco, Katie M AU - Goncharova, Ekaterina I AU - Young, Matthew R AU - Colburn, Nancy H AU - McMahon, James B AU - Henrich, Curtis J AD - Laboratory of Cancer Prevention, Gene Regulation Section, National Cancer Institute-Frederick, Frederick, MD Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 133 EP - 139 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 12 IS - 1 SN - 1087-0571, 1087-0571 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - AP-1 KW - high-throughput assay KW - natural products KW - b-lactamase KW - Protein kinase C KW - Curcumin KW - Activator protein 1 KW - Tumorigenesis KW - fluorescence resonance energy transfer KW - Cancer KW - Promoters KW - Cytotoxicity KW - Nordihydroguaiaretic acid KW - Transcription factors KW - b-Lactamase KW - N 14835:Protein-Nucleic Acids Association KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21201307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomolecular+Screening&rft.atitle=A+High-Throughput+Cell-Based+Assay+to+Identify+Specific+Inhibitors+of+Transcription+Factor+AP-1&rft.au=Ruocco%2C+Katie+M%3BGoncharova%2C+Ekaterina+I%3BYoung%2C+Matthew+R%3BColburn%2C+Nancy+H%3BMcMahon%2C+James+B%3BHenrich%2C+Curtis+J&rft.aulast=Ruocco&rft.aufirst=Katie&rft.date=2007-02-01&rft.volume=12&rft.issue=1&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomolecular+Screening&rft.issn=10870571&rft_id=info:doi/10.1177%2F1087057106296686 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Protein kinase C; Promoters; Cytotoxicity; Curcumin; Nordihydroguaiaretic acid; Transcription factors; Tumorigenesis; Activator protein 1; fluorescence resonance energy transfer; natural products; b-Lactamase; Cancer DO - http://dx.doi.org/10.1177/1087057106296686 ER - TY - JOUR T1 - Nominations for CERHR Expert Panel Evaluations AN - 21058449; 7596891 AB - Abstract not available. JF - Birth Defects Research Part B: Developmental and Reproductive Toxicology AU - Shelby, Michael D AD - Director, CERHR, NIEHS EC-32, P.O. Box 12233, RTP, NC 27709, shelby@niehs.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 1 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 80 IS - 1 SN - 1542-9733, 1542-9733 KW - Toxicology Abstracts KW - Sensory evaluation KW - Congenital defects KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21058449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.atitle=Nominations+for+CERHR+Expert+Panel+Evaluations&rft.au=Shelby%2C+Michael+D&rft.aulast=Shelby&rft.aufirst=Michael&rft.date=2007-02-01&rft.volume=80&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.issn=15429733&rft_id=info:doi/10.1002%2Fbdrb.20097 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Sensory evaluation; Congenital defects DO - http://dx.doi.org/10.1002/bdrb.20097 ER - TY - JOUR T1 - Quantification of alpha 4 beta 2* nicotinic receptors in the rat brain with microPET[registered] and 2-[ super(18)F]F-A-85380 AN - 21057148; 7345935 AB - The radioligand 2-[ super(18)F]F-A-85380 has been used for PET studies of the alpha 4 beta 2* subtype of nicotinic acetylcholine receptors (nAChRs) in the living brain of humans and nonhuman primates. In order to extend the capacity of microPET to quantify neuroreceptors in rat brain, we carried out studies of 2- [ super(18)F]F-A-85380 to measure the apparent binding potential BP* in individual rats, which were studied repeatedly over several months. Using a bolus-plus- infusion paradigm, 2-[ super(18)F]F-A-85380 (specific activity 20-1300 GBq/ mu mol) was administered intravenously over 8 to 9 h with K sub(bol) values of 350 to 440 min and a mean infusion rate of 0.03 +/- 0.01 nmol/kg/h. Studies included a 2-h nicotine infusion initiated 2 h before the end of scanning to displace specifically bound radioactivity. Steady state binding in brain was obtained within 5 h as defined by the occurrence of constant radioactivity concentrations in brain regions and constant, free arterial plasma levels of nonmetabolized radioligand. BP* averages (+/- SEM) for thalamus, forebrain, and cerebellum were 5.9 +/- 0.7, 2.6 +/- 0.4, and 1.0 +/- 0.1, respectively, which are consistent with the alpha 4 beta 2* nAChR distribution in rat brain measured in vitro. Studies of receptor occupancy determined the ED sub(50) to be 0.29 nmol/kg/h. The demonstration that alpha 4 beta 2* nAChRs are quantifiable in the rat brain using PET measurements, coupled with the ability to conduct longitudinal studies over several months in the same rats, suggests potential applications to studies of chronic nicotine use, its treatment, and abnormal functioning of alpha 4 beta 2* receptors in a rat model. JF - NeuroImage AU - Vaupel, DBruce AU - Stein, Elliot A AU - Mukhin, Alexey G Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 1352 EP - 1362 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 34 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Forebrain KW - Plasma levels KW - Scanning KW - Nicotine KW - Brain KW - Positron emission tomography KW - Cerebellum KW - Radioactivity KW - Primates KW - Acetylcholine receptors (nicotinic) KW - Thalamus KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21057148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Quantification+of+alpha+4+beta+2*+nicotinic+receptors+in+the+rat+brain+with+microPET%5Bregistered%5D+and+2-%5B+super%2818%29F%5DF-A-85380&rft.au=Vaupel%2C+DBruce%3BStein%2C+Elliot+A%3BMukhin%2C+Alexey+G&rft.aulast=Vaupel&rft.aufirst=DBruce&rft.date=2007-02-01&rft.volume=34&rft.issue=4&rft.spage=1352&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2006.10.036 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Forebrain; Plasma levels; Scanning; Nicotine; Cerebellum; Positron emission tomography; Brain; Radioactivity; Thalamus; Acetylcholine receptors (nicotinic); Primates DO - http://dx.doi.org/10.1016/j.neuroimage.2006.10.036 ER - TY - JOUR T1 - Metabolic syndrome in youth: current issues and challenges AN - 21017164; 9280228 JF - Applied Physiology, Nutrition, and Metabolism AU - Huang, Terry T-K AU - Ball, Geoff DC AU - Franks, Paul W AD - Endocrinology, Nutrition and Growth Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, 6100 Executive Boulevard, 4B11, Rockville, MD 20852, USA., huangter@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 13 EP - 22 PB - NRC Research Press VL - 32 IS - 1 SN - 1715-5312, 1715-5312 KW - Physical Education Index KW - Nutrition KW - Youth KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21017164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Physiology%2C+Nutrition%2C+and+Metabolism&rft.atitle=Metabolic+syndrome+in+youth%3A+current+issues+and+challenges&rft.au=Huang%2C+Terry+T-K%3BBall%2C+Geoff+DC%3BFranks%2C+Paul+W&rft.aulast=Huang&rft.aufirst=Terry&rft.date=2007-02-01&rft.volume=32&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Applied+Physiology%2C+Nutrition%2C+and+Metabolism&rft.issn=17155312&rft_id=info:doi/10.1139%2FH06-094 LA - English DB - Physical Education Index N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Nutrition; Youth DO - http://dx.doi.org/10.1139/H06-094 ER - TY - JOUR T1 - In vivo 13C saturation transfer effect of the lactate dehydrogenase reaction AN - 20860434; 8368381 AB - Lactate dehydrogenase (LDH, EC 1.1.1.27) catalyzes an exchange reaction between pyruvate and lactate. It is demonstrated here that this reaction is sufficiently fast to cause a significant magnetization (saturation) transfer effect when the 13C resonance of pyruvate is saturated by a continuous-wave (CW) RF pulse. Infusion of [2-13C]glucose was used to allow labeling of pyruvate C2 at 207.9 ppm to determine the pseudo first-order rate constant of the unidirectional lactate pyruvate flux in vivo. During systemic administration of GABAA receptor antagonist bicuculline, this pseudo first-order rate constant was determined to be 0.08 - 0.01 s-1 (mean - SD, N = 4) in halothane-anesthetized adult rat brains. In 9L and C6 rat glioma models, the 13C saturation transfer effect of the LDH reaction was also detected in vivo. Our results demonstrate that the 13C magnetization transfer effect of the LDH reaction may be useful as a novel marker for utilizing noninvasive in vivo MRS to study many physiological and pathological conditions, such as cancer. Magn Reson Med 57:258-264, 2007. JF - Magnetic Resonance in Medicine AU - Xu, Su AU - Yang, Jehoon AU - Shen, Jun AD - Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland, USA, shenj@intra.nimh.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 258 EP - 264 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 57 IS - 2 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Brain tumors KW - ^g-Aminobutyric acid A receptors KW - Pyruvic acid KW - Animal models KW - Brain KW - Lactic acid KW - Bicuculline KW - N.M.R. KW - Glioma KW - L-Lactate dehydrogenase KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20860434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=In+vivo+13C+saturation+transfer+effect+of+the+lactate+dehydrogenase+reaction&rft.au=Xu%2C+Su%3BYang%2C+Jehoon%3BShen%2C+Jun&rft.aulast=Xu&rft.aufirst=Su&rft.date=2007-02-01&rft.volume=57&rft.issue=2&rft.spage=258&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21137 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Pyruvic acid; L-Lactate dehydrogenase; Lactic acid; Brain; N.M.R.; Animal models; ^g-Aminobutyric acid A receptors; Glioma; Brain tumors; Bicuculline DO - http://dx.doi.org/10.1002/mrm.21137 ER - TY - JOUR T1 - Novel strategy for cerebral 13C MRS using very low RF power for proton decoupling AN - 20857715; 8368382 AB - One of the major difficulties of in vivo 13C MRS is the need to decouple the large, one-bond, 1H-13C scalar couplings in order to obtain useful signal-to-noise ratios (SNRs) and spectral resolution at magnetic field strengths that are accessible to clinical studies. In this report a new strategy for in vivo cerebral 13C MRS is proposed. We realized that the turnover kinetics of glutamate (Glu) C5 from exogenous [2-13C]glucose (Glc) is identical to that of Glu C4 from exogenous [1-13C]Glc. The carboxylic/amide carbons are only coupled to protons via very weak long-range 1H-13C scalar couplings. As such, they can be effectively decoupled at very low RF power. Therefore, decoupling of the large 1H-13C scalar couplings can be avoided by the use of [2-13C]Glc. An additional advantage of this strategy is the lack of contamination from subcutaneous lipids because there are no overlapping fat signals in the vicinity of the Glu C5 and glutamine (Gln) C5 peaks. The feasibility of this strategy was demonstrated using 13C MRS on rhesus monkey brains at 4.7T. Magn Reson Med 57:265-271, 2007. JF - Magnetic Resonance in Medicine AU - Li, Shizhe AU - Yang, Jehoon AU - Shen, Jun AD - Magnetic Resonance Spectroscopy Core Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA, shenj@intra.nimh.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 265 EP - 271 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 57 IS - 2 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Glutamine KW - Contamination KW - Lipids KW - Carbon KW - N.M.R. KW - Macaca mulatta KW - Protons KW - Brain KW - Magnetic fields KW - Kinetics KW - Glutamic acid KW - amides KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20857715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Novel+strategy+for+cerebral+13C+MRS+using+very+low+RF+power+for+proton+decoupling&rft.au=Li%2C+Shizhe%3BYang%2C+Jehoon%3BShen%2C+Jun&rft.aulast=Li&rft.aufirst=Shizhe&rft.date=2007-02-01&rft.volume=57&rft.issue=2&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21148 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Macaca mulatta; Protons; Lipids; Carbon; Magnetic fields; Glutamic acid; Brain; N.M.R.; amides; Kinetics; Glutamine; Contamination DO - http://dx.doi.org/10.1002/mrm.21148 ER - TY - JOUR T1 - Real-time shimming to compensate for respiration-induced B0 fluctuations AN - 20856695; 8368392 AB - In MRI of human brain, the respiratory cycle can induce B0-field fluctuations through motion of the chest and fluctuations in local oxygen concentration. The associated NMR frequency changes can affect the MRI data in various ways and lead to temporal signal fluctuations, and image artifacts such as ghosting and blurring. Since the size of the effect scales with magnetic field strength, artifacts become particularly problematic at fields above 3.0T. Furthermore, the spatial dependence of the B0-field fluctuations complicates their correction. In this work, a new method is presented that allows compensation of field fluctuations by modulating the B0 shims in real time. In this method, a reference scan is acquired to measure the spatial distribution of the B0 effect related to chest motion. During the actual scan, this information is then used, together with chest motion data, to apply compensating B0 shims in real time. The method can be combined with any type of scan without modifications to the pulse sequence. Real-time B0 shimming is demonstrated to substantially improve the phase stability of EPI data and the image quality of multishot gradient-echo (GRE) MRI at 7T. Magn Reson Med 57:362-368, 2007. JF - Magnetic Resonance in Medicine AU - van Gelderen, P AU - de Zwart, J A AU - Starewicz, P AU - Hinks, R S AU - Duyn, J H AD - Advanced MRI, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA, gelderen@nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 362 EP - 368 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 57 IS - 2 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Data processing KW - Spatial distribution KW - Magnetic resonance imaging KW - Brain KW - Chest KW - Magnetic fields KW - N.M.R. KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20856695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Real-time+shimming+to+compensate+for+respiration-induced+B0+fluctuations&rft.au=van+Gelderen%2C+P%3Bde+Zwart%2C+J+A%3BStarewicz%2C+P%3BHinks%2C+R+S%3BDuyn%2C+J+H&rft.aulast=van+Gelderen&rft.aufirst=P&rft.date=2007-02-01&rft.volume=57&rft.issue=2&rft.spage=362&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21136 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; Data processing; Chest; N.M.R.; Spatial distribution; Magnetic fields; Brain DO - http://dx.doi.org/10.1002/mrm.21136 ER - TY - JOUR T1 - Therapy for Gaucher disease: Don't stop thinking about tomorrow AN - 20806238; 7656531 AB - While enzyme replacement therapy for Gaucher disease has been widely used and appears to be an efficacious and safe treatment, this success should not be a reason for complacency. Other treatment strategies currently under consideration for patients with Gaucher disease include gene therapy, substrate reduction therapy and chaperone therapy. Furthermore, improvements in enzyme therapy could also have a significant clinical impact. Individuals with Gaucher disease and other lysosomal disorders will greatly benefit from continual refinement and optimization of the current therapy, as well as from the development of new treatment modalities that offer improvements in efficacy, cost, safety and availability. JF - Molecular Genetics and Metabolism AU - Sidransky, Ellen AU - Lamarca, Mary E AU - Ginns, Edward I AD - Section on Molecular Neurogenetics, Medical Genetics Branch, National Human Genome Research Institute, NIH, Building 35, Room 1A213, 35 Convent Drive, MSC 3708, Bethesda, MD 20892, USA, sidranse@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 122 EP - 125 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 90 IS - 2 SN - 1096-7192, 1096-7192 KW - Biotechnology and Bioengineering Abstracts KW - Gaucher disease KW - Enzyme replacement therapy KW - Lysosomal storage diseases KW - Chaperone therapy KW - Gene therapy KW - Substrate reduction therapy KW - Gaucher's disease KW - Enzymes KW - Chaperones KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20806238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Genetics+and+Metabolism&rft.atitle=Therapy+for+Gaucher+disease%3A+Don%27t+stop+thinking+about+tomorrow&rft.au=Sidransky%2C+Ellen%3BLamarca%2C+Mary+E%3BGinns%2C+Edward+I&rft.aulast=Sidransky&rft.aufirst=Ellen&rft.date=2007-02-01&rft.volume=90&rft.issue=2&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Molecular+Genetics+and+Metabolism&rft.issn=10967192&rft_id=info:doi/10.1016%2Fj.ymgme.2006.09.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gene therapy; Gaucher's disease; Enzymes; Chaperones DO - http://dx.doi.org/10.1016/j.ymgme.2006.09.007 ER - TY - JOUR T1 - Common Genetic Variation in TP53 Is Associated with Lung Cancer Risk and Prognosis in African Americans and Somatic Mutations in Lung Tumors AN - 20722716; 7286882 AB - Lung cancer is primarily caused by tobacco smoking, but susceptibility is likely modified by common genetic variation. In response to many forms of cellular stress, including DNA damage, the p53 protein functions to induce cell cycle arrest, DNA repair, senescence, or apoptosis. We hypothesized that common TP53 haplotypes modulate pathways of lung carcinogenesis and lung cancer susceptibility or prognosis. To investigate our hypothesis, 14 polymorphisms in TP53, including haplotype tagging and coding single nucleotide polymorphisms, were genotyped in two studies from the greater Baltimore, Maryland area. One study is a case-control study and the second is a case-only study for which TP53 mutational spectra data are available. African Americans with Pro-T-A-G-G haplotypes of the combined TP53 polymorphisms TP53_01 (rs1042522), TP53_65 (rs9895829), TP53_66 (rs2909430), TP53_16 (rs1625895), and TP53_11 (rs12951053) had both an increased risk for lung cancer (odds ratio, 2.32; 95% confidence interval, 1.18-4.57) and a worsened lung cancer prognosis (hazards ratio, 2.38; 95% confidence interval, 1.38-4.10) compared with those with Arg-T-A-G-T haplotypes. No associations of TP53 polymorphisms with lung cancer were observed in Caucasians. In the case-only study, several polymorphisms in TP53 and TP53 haplotypes, overlapping regions of TP53 associated with risk and prognosis in African Americans, were associated with increased odds of somatic TP53 mutation in lung tumors in Caucasians. In conclusion, common genetic variation in TP53 could modulate lung cancer pathways, as suggested by the association with lung cancer in African Americans and somatic TP53 mutation frequency in lung tumors. (Cancer Epidemiol Biomarkers Prev 2007; 16(2):214-22) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Mechanic, Leah E AU - Bowman, Elise D AU - Welsh, Judith A AU - Khan, Mohammed A AU - Hagiwara, Nobutoshi AU - Enewold, Lindsey AU - Shields, Peter G AU - Burdette, Laurie AU - Chanock, Stephen AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, National Cancer Institute, Center for Cancer Research, Bethesda, Maryland Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 214 EP - 222 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 2 SN - 1055-9965, 1055-9965 KW - Genetics Abstracts; Risk Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Oncogenes & Growth Factors Abstracts KW - Apoptosis KW - Gene polymorphism KW - Cell cycle KW - Genetic diversity KW - tumors KW - USA, Maryland, Baltimore KW - Smoking KW - Haplotypes KW - Tobacco KW - prevention KW - Ethnic groups KW - Lung cancer KW - Bioindicators KW - Tobacco smoking KW - Data processing KW - Prognosis KW - Stress KW - genetic diversity KW - haplotypes KW - Tumors KW - DNA repair KW - biomarkers KW - Cancer KW - p53 protein KW - DNA damage KW - Single-nucleotide polymorphism KW - Carcinogenesis KW - senescence KW - DNA KW - Africa KW - Proteins KW - Senescence KW - Mutation KW - G 07880:Human Genetics KW - N 14820:DNA Metabolism & Structure KW - B 26670:Tumor Suppressors KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20722716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Common+Genetic+Variation+in+TP53+Is+Associated+with+Lung+Cancer+Risk+and+Prognosis+in+African+Americans+and+Somatic+Mutations+in+Lung+Tumors&rft.au=Mechanic%2C+Leah+E%3BBowman%2C+Elise+D%3BWelsh%2C+Judith+A%3BKhan%2C+Mohammed+A%3BHagiwara%2C+Nobutoshi%3BEnewold%2C+Lindsey%3BShields%2C+Peter+G%3BBurdette%2C+Laurie%3BChanock%2C+Stephen%3BHarris%2C+Curtis+C&rft.aulast=Mechanic&rft.aufirst=Leah&rft.date=2007-02-01&rft.volume=16&rft.issue=2&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Tobacco smoking; Data processing; Apoptosis; Gene polymorphism; Cell cycle; Prognosis; Genetic diversity; Stress; Tumors; DNA repair; biomarkers; p53 protein; DNA damage; Haplotypes; Single-nucleotide polymorphism; Carcinogenesis; Senescence; Mutation; Lung cancer; Bioindicators; tumors; genetic diversity; haplotypes; Cancer; Smoking; prevention; DNA; Tobacco; senescence; Proteins; Ethnic groups; Africa; USA, Maryland, Baltimore ER - TY - JOUR T1 - Secular trends in the association of socio-economic position with self-reported dietary attributes and biomarkers in the US population: National Health and Nutrition Examination Survey (NHANES) 1971-1975 to NHANES 1999-2002 AN - 20699292; 10837806 AB - Recent reports suggest persistence of health disparities related to socio-economic position (SEP). To understand if diet may be a contributor to these trends, we examined secular trends in the association of diet and indicators of SEP from 1971-1975 to 1999-2002. We used data from the National Health and Nutrition Examination Surveys (NHANES) I (1971-1975), II (1976-1980), III (1988-1994) and 1999-2002 to examine the independent associations of poverty income ratio (PIR) and education with diet and biomarkers of diet and disease in 25-74-year-olds (n=36600). We used logistic and linear regression methods to adjust for multiple covariates and survey design to examine these associations. A large PIR differential in the likelihood of reporting a fruit or all five food groups and vitamin C intake, and an education differential in likelihood of obesity and carbohydrate intake, was noted in 1971-1975 but narrowed in 1999-2002 (P<0.007). The positive association of education with intake of a fruit, vegetable or all five food groups, vitamins A and C, calcium and potassium intake remained unchanged across surveys (P<0.001). Similarly, the positive association of PIR with the amount of foods and intakes of energy and potassium remained unchanged over three decades (P<0.001). The education and the PIR differential in energy density, and the PIR differential in the likelihood of obesity, persisted over the period of the four surveys (P<0.001). Persistence of unfavourable dietary and biomarker profiles in Americans with low income and education suggests continued need for improvement in the quality of diets of these high-risk groups. JF - Public Health Nutrition AU - Kant, Ashima K AU - Graubard, Barry I AD - Division of Cancer Epidemiology and Genetics, Biostatistics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, ashima.kant@qc.cuny.edu Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 158 EP - 167 PB - Cambridge University Press, 32 Avenue of the Americas New York NY 10013-2473 USA VL - 10 IS - 2 SN - 1368-9800, 1368-9800 KW - Risk Abstracts KW - Calcium KW - obesity KW - Socioeconomics KW - Nutrition KW - vitamins KW - poverty KW - income KW - Carbohydrates KW - Bioindicators KW - Diets KW - fruits KW - Potassium KW - Education KW - USA KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20699292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Nutrition&rft.atitle=Secular+trends+in+the+association+of+socio-economic+position+with+self-reported+dietary+attributes+and+biomarkers+in+the+US+population%3A+National+Health+and+Nutrition+Examination+Survey+%28NHANES%29+1971-1975+to+NHANES+1999-2002&rft.au=Kant%2C+Ashima+K%3BGraubard%2C+Barry+I&rft.aulast=Kant&rft.aufirst=Ashima&rft.date=2007-02-01&rft.volume=10&rft.issue=2&rft.spage=158&rft.isbn=&rft.btitle=&rft.title=Public+Health+Nutrition&rft.issn=13689800&rft_id=info:doi/10.1017%2FS1368980007246749 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; Diets; Education; Bioindicators; fruits; Nutrition; income; obesity; Socioeconomics; Potassium; vitamins; poverty; Calcium; Carbohydrates DO - http://dx.doi.org/10.1017/S1368980007246749 ER - TY - JOUR T1 - Expression levels of eIF4E, VEGF, and cyclin D1, and correlation of eIF4E with VEGF and cyclin D1 in multi-tumor tissue microarray AN - 20631589; 9360674 AB - The mRNA cap-binding protein, eukaryotic initiation factor 4E (eIF4E), is a rate-limiting factor of cap-dependent translation initiation. When elevated, eIF4E greatly facilitates translation of a selected spectrum of mRNAs coding for proteins critical to angiogenesis and growth such as vascular endothelial growth factor (VEGF) and cyclin D1. Expression levels of eIF4E, VEGF, and cyclin D1 were examined in multi-tumor tissue microarray by immunohistochemistry and analyzed quantitatively. eIF4E, VEGF and cyclin D1 protein were elevated in tumors of the breast (62, 78, or 40%), colon (72, 77, or 12%), glioblastoma multiforme (48, 68, or 52%), lymphoma (66, 74, or 38%), melanoma (59, 73, or 58%), NSCLC (81, 82, or 29%), ovary (50, 39, or 13%), and prostate (78, 97, or 21%), respectively. eIF4E levels were strongly correlated with VEGF and cyclin D1 in melanoma (Spearman's r=0.97 and 0.77; all P0.15). The significant association of eIF4E with VEGF and cyclin D1 in multiple tumors supports a role for eIF4E in translational regulation of proteins related to angiogenesis and growth. JF - Oncology Reports AU - Yang, S X AU - Hewitt, S M AU - Steinberg, S M AU - Liewehr, D J AU - Swain, S M AD - National Clinical Target Validation Laboratory, Division of Cancer Treatment and Diagnosis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA, yangxia@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 281 EP - 287 VL - 17 IS - 2 SN - 1021-335X, 1021-335X KW - Oncogenes & Growth Factors Abstracts; Biotechnology and Bioengineering Abstracts KW - Vascular endothelial growth factor KW - Translation KW - Translation initiation KW - glioblastoma multiforme KW - Angiogenesis KW - Tumors KW - Initiation factor eIF-4E KW - Melanoma KW - Colon KW - Lung KW - Ovaries KW - Lymphoma KW - Prostate KW - cap-binding protein KW - Immunohistochemistry KW - cyclin D1 KW - B 26600:Tyrosine Kinase Activity KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20631589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology+Reports&rft.atitle=Expression+levels+of+eIF4E%2C+VEGF%2C+and+cyclin+D1%2C+and+correlation+of+eIF4E+with+VEGF+and+cyclin+D1+in+multi-tumor+tissue+microarray&rft.au=Yang%2C+S+X%3BHewitt%2C+S+M%3BSteinberg%2C+S+M%3BLiewehr%2C+D+J%3BSwain%2C+S+M&rft.aulast=Yang&rft.aufirst=S&rft.date=2007-02-01&rft.volume=17&rft.issue=2&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=Oncology+Reports&rft.issn=1021335X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Vascular endothelial growth factor; Translation; glioblastoma multiforme; Translation initiation; Angiogenesis; Tumors; Initiation factor eIF-4E; Melanoma; Colon; Lung; Ovaries; Immunohistochemistry; cap-binding protein; Prostate; Lymphoma; cyclin D1 ER - TY - JOUR T1 - Mechanisms of Acquired Androgen Independence during Arsenic-Induced Malignant Transformation of Human Prostate Epithelial Cells AN - 20582651; 7305653 AB - BACKGROUND: Prostate cancer progression often occurs with overexpression of growth factors and receptors, many of which engage the Ras/mitogen-activated protein MAP kinase (MAPK) pathway. OBJECTIVES: In this study we used arsenic-transformed human prostate epithelial cells, which also show androgen-independent growth, to study the possibility that chronic activation of Ras/MAPK signaling may contribute to arsenic-induced prostate cancer progression. METHODS: Control and chronic arsenic-transformed prostate epithelial cells (CAsE-PE) were compared for Ras/MAPK signaling capacities using reverse transcription-polymerase chain reaction and Western blot analyses. RESULTS: We found activation of HER-2/neu oncogene in transformed CAsE-PE cells, providing molecular evidence of androgen independence in the transformed cells. CAsE-PE cells displayed constitutively increased expression of unmutated K-Ras (6-fold), and the downstream MAP kinases A-Raf and B-Raf (2.2-fold and 3.2-fold, respectively). There was also increased expression of phosphorylated MEK1/2 and Elk1 in the transformant cells. The MEK1/2 inhibitor, U0126, blocked PSA overexpression in CAsE-PE cells. CONCLUSION: Thus, arsenic-induced malignant transformation and acquired androgen independence are linked to Ras signaling activation in human prostate epithelial cells. Chronic activation of this pathway can sensitize the androgen receptor to subphysiologic levels of androgen. This may be important in arsenic carcinogenesis and provide a mechanism that may be common for prostate cancer progression driven by diverse agents. JF - Environmental Health Perspectives AU - Benbrahim-Tallaa, L AU - Webber, M M AU - Waalkes, M P AD - NCI at NIEHS, P.O. Box 12233, Mail Drop F0-09, 111 Alexander Dr., Research Triangle Park, NC 27709, USA, waalkes@niehs.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 243 EP - 247 VL - 115 IS - 2 SN - 0091-6765, 0091-6765 KW - Toxicology Abstracts KW - Transformation KW - Ras protein KW - Western blotting KW - Epithelial cells KW - MAP kinase KW - Arsenic KW - ErbB-2 protein KW - Transformed cells KW - Androgen receptors KW - K-Ras protein KW - Prostate cancer KW - Oncogenes KW - Carcinogenesis KW - Growth factors KW - Signal transduction KW - Androgens KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20582651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Mechanisms+of+Acquired+Androgen+Independence+during+Arsenic-Induced+Malignant+Transformation+of+Human+Prostate+Epithelial+Cells&rft.au=Benbrahim-Tallaa%2C+L%3BWebber%2C+M+M%3BWaalkes%2C+M+P&rft.aulast=Benbrahim-Tallaa&rft.aufirst=L&rft.date=2007-02-01&rft.volume=115&rft.issue=2&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.9630 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Ras protein; Transformation; Epithelial cells; Western blotting; Arsenic; MAP kinase; ErbB-2 protein; Transformed cells; Androgen receptors; K-Ras protein; Oncogenes; Prostate cancer; Carcinogenesis; Growth factors; Androgens; Signal transduction DO - http://dx.doi.org/10.1289/ehp.9630 ER - TY - JOUR T1 - Protection of antiterminator RNA by the transcript elongation complex AN - 20454907; 9149992 AB - SummaryNascent transcripts encoded by the putL and putR sites of phage HK022 bind the transcript elongation complex and suppress termination at downstream transcription terminators. We report here that the chemical stability of putL RNA is considerably greater than that of the typical Escherichia coli message because the elongation complex protects this RNA from degradation. When binding to the elongation complex was prevented by mutation of either putL or RNA polymerase, RNA stability decreased more than 50-fold. The functional modification conferred by putL RNA on the elongation complex is also long-lived: the efficiency of terminator suppression remained high for at least 10kb from the putL site. We find that RNase III rapidly and efficiently cleaved the transcript just downstream of the putL sequences, but such cleavage changed neither the stability of putL RNA nor the efficiency of antitermination. These results argue that the continuity of the RNA that connects put sequences to the growing point is not required for persistence of the antiterminating modification in vivo. JF - Molecular Microbiology AU - Sloan, Sieghild AU - Rutkai, Edit AU - King, Rodney A AU - Velikodvorskaya, Tatyana AU - Weisberg, Robert A AD - Section on Microbial Genetics, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD20892-2785, USA. Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 1197 EP - 1208 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 63 IS - 4 SN - 0950-382X, 0950-382X KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Phages KW - Elongation KW - DNA-directed RNA polymerase KW - Escherichia coli KW - Phage HK022 KW - Transcription KW - Ribonuclease III KW - Mutation KW - J 02410:Animal Diseases KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20454907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Protection+of+antiterminator+RNA+by+the+transcript+elongation+complex&rft.au=Sloan%2C+Sieghild%3BRutkai%2C+Edit%3BKing%2C+Rodney+A%3BVelikodvorskaya%2C+Tatyana%3BWeisberg%2C+Robert+A&rft.aulast=Sloan&rft.aufirst=Sieghild&rft.date=2007-02-01&rft.volume=63&rft.issue=4&rft.spage=1197&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2006.05579.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Phages; Elongation; DNA-directed RNA polymerase; Ribonuclease III; Transcription; Mutation; Escherichia coli; Phage HK022 DO - http://dx.doi.org/10.1111/j.1365-2958.2006.05579.x ER - TY - JOUR T1 - Age-Dependent Variation in Behavior Following Acute Ethanol Administration in Male and Female Adolescent Rhesus Macaques (Macaca mulatta) AN - 20433052; 9121173 AB - Background: There has been considerable focus on the adolescent stage of development in the study of alcohol use and the etiology of alcohol-related problems. Because adolescence is a process of dynamic change rather than a discrete or static stage of development, it is important to consider ontogenetic changes in the response to ethanol within the adolescent time period. In rodents, levels of ethanol-induced motor impairment have been shown to increase from early to late adolescence. This study investigated associations between behavior following acute ethanol administration and age, rearing condition (mother-reared vs nursery-reared), and serotonin transporter (rh5-HTTLPR) genotype in a sample of alcohol-naive adolescent rhesus macaques.Methods: Rhesus macaques (n=97; 41 males, 56 females), ranging in age from 28 to 48 months, were administered intravenous (IV) doses of ethanol (2.2 g/kg for males, 2.0 g/kg for females) twice in 2 separate testing sessions. A saline/ethanol group (n=16; 8 males, 6 females) was administered saline in 1 testing session and ethanol in the second session. Following each IV injection, subjects underwent a 30-minute general motor behavioral assessment. Behavior in the saline/ethanol group was compared between the saline and ethanol-testing sessions using analysis of variance. Behavioral data for the larger study sample were averaged between the 2 testing sessions and summarized using factor analysis. Rotated factor scores were used as dependent variables in multiple regression analyses to test for relationships between behavior and age, rearing condition, and rh5-HTTLPR genotype.Results: During the ethanol-testing session, behaviors indicative of motor impairment (stumbles, falls, sways, bumping the wall, and unsuccessful jumps) were frequently observed in the saline/ethanol group, while they did not occur under the saline-testing session. Factor analysis of behavior following ethanol administration in the larger study sample yielded 3 factors: Ataxia, Impaired Jumping Ability, and Stimulation. Significant negative correlations between age and Ataxia were found for both males and females. Females also exhibited positive correlations between age and Impaired Jumping Ability and age and Stimulation. No significant correlations were found with either rearing condition or rh5-HTTLPR genotype.Conclusions: These findings suggest that ontogenetic changes during adolescence in the behavioral response to ethanol differ between rodents and primates. Furthermore, sex differences in the behavioral response to ethanol appear to develop during adolescence. JF - Alcoholism: Clinical and Experimental Research AU - Schwandt, Melanie L AU - Barr, Christina S AU - Suomi, Stephen J AU - Higley, James D AD - Laboratory of Clinical and Translational Studies, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center, Poolesville, Maryland Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 228 EP - 237 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 31 IS - 2 SN - 0145-6008, 0145-6008 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Nonhuman Primate KW - Alcohol KW - Adolescence KW - Sex Differences KW - Development KW - Intravenous administration KW - Jumping KW - Age KW - Etiology KW - Data processing KW - Factor analysis KW - Multiple regression analysis KW - Developmental stages KW - Genotypes KW - Sex differences KW - Drug abuse KW - Primates KW - Alcoholism KW - Ataxia KW - Ontogeny KW - Macaca mulatta KW - Serotonin transporter KW - Ethanol KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20433052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%3A+Clinical+and+Experimental+Research&rft.atitle=Age-Dependent+Variation+in+Behavior+Following+Acute+Ethanol+Administration+in+Male+and+Female+Adolescent+Rhesus+Macaques+%28Macaca+mulatta%29&rft.au=Schwandt%2C+Melanie+L%3BBarr%2C+Christina+S%3BSuomi%2C+Stephen+J%3BHigley%2C+James+D&rft.aulast=Schwandt&rft.aufirst=Melanie&rft.date=2007-02-01&rft.volume=31&rft.issue=2&rft.spage=228&rft.isbn=&rft.btitle=&rft.title=Alcoholism%3A+Clinical+and+Experimental+Research&rft.issn=01456008&rft_id=info:doi/10.1111%2Fj.1530-0277.2006.00300.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Etiology; Age; Jumping; Intravenous administration; Data processing; Adolescence; Factor analysis; Developmental stages; Multiple regression analysis; Genotypes; Drug abuse; Sex differences; Alcoholism; Ataxia; Ontogeny; Serotonin transporter; Ethanol; Macaca mulatta; Primates DO - http://dx.doi.org/10.1111/j.1530-0277.2006.00300.x ER - TY - JOUR T1 - Shotgun electroelution: A proteomic tool for simultaneous sample elution from whole SDS-polyacrylamide gel slabs AN - 20403603; 7762570 AB - A high-throughput device has been constructed which allows parallel electroelution of separated SDS-protein bands directly from intact unsectioned polyacrylamide gel slabs as well as single electroelution of certain protein spots into a 384-well standard flat-bottom multiwell plate. The prototype provides complete, quick elution for proteomics from 1-D or from 2-D gels without gel sectioning. Since the elution chamber matrix requires no assembly, sample handling can be easily carried out by existing robotic workstations. The current design is a good candidate for automation of spot elution since there are no moving liquid containing components in the apparatus. Eight SDS-proteins were eluted in test runs and an average 70% sample recovery was achieved by re-electrophoresis of the electroeluates. JF - Electrophoresis AU - Antal, Jozsef AU - Banyasz, Borbala AU - Buzas, Zsuzsanna AD - Section on Metabolic Analysis and Mass Spectrometry, Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA, zbuzas@yahoo.com Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 508 EP - 511 PB - Wiley-VCH, Postfach 101161 Weinheim 69451 Germany, [mailto:info@wiley-vch.de], [URL:http://www.wiley-vch.de/publish/en/] VL - 28 IS - 4 SN - 0173-0835, 0173-0835 KW - Biotechnology and Bioengineering Abstracts KW - Gels KW - Sectioning KW - Automation KW - robotics KW - proteomics KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20403603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Electrophoresis&rft.atitle=Shotgun+electroelution%3A+A+proteomic+tool+for+simultaneous+sample+elution+from+whole+SDS-polyacrylamide+gel+slabs&rft.au=Antal%2C+Jozsef%3BBanyasz%2C+Borbala%3BBuzas%2C+Zsuzsanna&rft.aulast=Antal&rft.aufirst=Jozsef&rft.date=2007-02-01&rft.volume=28&rft.issue=4&rft.spage=508&rft.isbn=&rft.btitle=&rft.title=Electrophoresis&rft.issn=01730835&rft_id=info:doi/10.1002%2Felps.200600634 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - proteomics; robotics; Gels; Automation; Sectioning DO - http://dx.doi.org/10.1002/elps.200600634 ER - TY - JOUR T1 - Increased immunofluorescence sensitivity using 532 nm laser excitation AN - 20397223; 7760069 AB - Objective: We evaluated the use of a high power, diode pulsed solid-state laser emitting 532 nm light for immunofluorescence applications. We compared the sensitivity and utility of this laser with the standard 488 nm excitation. Methods: A flow cytometer was equipped with both a 488 nm and a 532 nm laser; fluorescence emissions from each laser were collected using the same filters and the same detector system. Cells or compensation beads (e.g. latex beads coated with anti- antibodies) were stained with monoclonal antibodies conjugated to phycoerythrin (PE) as well as the PE tandem dyes TRPE, Cy5PE, Cy5.5PE, and Cy7PE. The sensitivity of detection of these reagents as well as those in heavily compensated channels was quantified by measuring the spreading error for a primary detector into a secondary detector. Results: Measurement of the fluorescence emission of PE and PE-tandem dyes was considerably more sensitive when using 532 nm excitation (150 mW) as compared with 488 nm excitation (20 mW). In addition, as the absolute number of photoelectrons collected was greater, there was less measurement-error-induced spread into the compensated channels. As an example, when comparing the spreading error of PE labeled cells into the TRPE detector, the green laser was found to be 15-fold more sensitive as compared with the blue laser. In addition, the blue laser produced more autofluoresent signal from cells as compared with the green laser. Together, these advantages of the 532 nm excitation line provides for a significantly improved detection of immunofluorescence staining. JF - Cytometry Part A AU - Perfetto, Stephen P AU - Roederer, Mario AD - Vaccine Research Center, NIAID, NIH, Bethesda, MD, sperfetto@nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 73 EP - 79 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 71A IS - 2 SN - 1552-4922, 1552-4922 KW - Biotechnology and Bioengineering Abstracts KW - Filters KW - phycoerythrins KW - Fluorescence KW - Spreading KW - Dyes KW - Monoclonal antibodies KW - Latex beads KW - Lasers KW - Immunofluorescence KW - Cytometry KW - Light effects KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20397223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytometry+Part+A&rft.atitle=Increased+immunofluorescence+sensitivity+using+532+nm+laser+excitation&rft.au=Perfetto%2C+Stephen+P%3BRoederer%2C+Mario&rft.aulast=Perfetto&rft.aufirst=Stephen&rft.date=2007-02-01&rft.volume=71A&rft.issue=2&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Cytometry+Part+A&rft.issn=15524922&rft_id=info:doi/10.1002%2Fcyto.a.20358 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Lasers; Immunofluorescence; Spreading; Dyes; Fluorescence; Latex beads; Monoclonal antibodies; phycoerythrins; Light effects; Cytometry; Filters DO - http://dx.doi.org/10.1002/cyto.a.20358 ER - TY - JOUR T1 - Emissions of polycyclic aromatic hydrocarbons (PAHs) from the pyrolysis of scrap tires AN - 20360416; 7573354 AB - This work investigated the PAHs generated in a waste-tire pyrolysis process and the PAHs removal by a wet scrubber (WSB) and a flare. IND, DBA, and BaP were found to dominate in the powders of scrap tires before the pyrolysis. The PAHs in the carbon blacks formed in the pyrolysis were mainly 2-, 3-, 6-, and 7-ring PAHs. Nap was the most predominant water-phase PAH in the WSB effluent. About 40% of the water-phase total-PAHs in the WSB effluent were contributed by nine carcinogenic PAHs. NaP, IND, and COR displayed higher mean gas- and particulate-phase concentrations than the other PAHs in the flare exhaust. The mean removal efficiencies of individual PAHs, total-PAHs, and high carcinogenic BaP+IND+DBA were 39.1-90.4%, 76.2%, and 84.9%, respectively for the WSB. For the flare, the mean removal efficiencies of gaseous, particulate, and combined (gaseous+particulate) total-PAHs were 59.8%, 91.2%, and 66.8%, respectively, whereas the removal efficiencies were 91.0%, 80.1%, and 89.1%, respectively for the total-BaPeq. However, the gaseous BaA displayed a negative mean removal efficiency. The total PAH emission rate and factor estimated for the scrap tire pyrolysis plant were 42.3gd-1 and 4.00mgkg-tire-1, respectively. JF - Atmospheric Environment AU - Chen, Shui-Jen AU - Su, Hung-Bin AU - Chang, Juu-En AU - Lee, Wen-Jhy AU - Huang, Kuo-Lin AU - Hsieh, Lien-Te AU - Huang, Yi-Chu AU - Lin, Wen-Yinn AU - Lin, Chih-Chung AD - Department of Environmental Engineering and Science, National Pingtung University of Science and Technology, Nei Pu, PingTung 91201, Taiwan, ROC, huangkL@mail.npust.edu.tw Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 1209 EP - 1220 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 41 IS - 6 SN - 1352-2310, 1352-2310 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - PAHs KW - Pyrolysis KW - Tires KW - Air pollution control devices (APCDs) KW - Air pollution control KW - Particulates KW - Effluents KW - Polycyclic aromatic hydrocarbon emissions KW - black carbon KW - Carcinogenicity KW - Particulate matter emissions KW - Scrubbers KW - Emissions KW - polycyclic aromatic hydrocarbons KW - Pollution control equipment KW - Polycyclic aromatic hydrocarbons in atmosphere KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20360416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Emissions+of+polycyclic+aromatic+hydrocarbons+%28PAHs%29+from+the+pyrolysis+of+scrap+tires&rft.au=Chen%2C+Shui-Jen%3BSu%2C+Hung-Bin%3BChang%2C+Juu-En%3BLee%2C+Wen-Jhy%3BHuang%2C+Kuo-Lin%3BHsieh%2C+Lien-Te%3BHuang%2C+Yi-Chu%3BLin%2C+Wen-Yinn%3BLin%2C+Chih-Chung&rft.aulast=Chen&rft.aufirst=Shui-Jen&rft.date=2007-02-01&rft.volume=41&rft.issue=6&rft.spage=1209&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2006.09.041 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Particulate matter emissions; Polycyclic aromatic hydrocarbons in atmosphere; Polycyclic aromatic hydrocarbon emissions; Pyrolysis; black carbon; Carcinogenicity; Scrubbers; Tires; Emissions; polycyclic aromatic hydrocarbons; Air pollution control; Particulates; Pollution control equipment; Effluents DO - http://dx.doi.org/10.1016/j.atmosenv.2006.09.041 ER - TY - JOUR T1 - Safety, immunogenicity and efficacy of modified vaccinia Ankara (MVA) against Dryvax challenge in vaccinia-naive and vaccinia-immune individuals AN - 20282778; 7640449 AB - Modified vaccinia Ankara (MVA) was evaluated as an alternative to Dryvax® in vaccinia-naive and vaccinia-immune adult volunteers. Subjects received intramuscular MVA or placebo followed by Dryvax® challenge at 3 months. Two or more doses of MVA prior to Dryvax® reduced severity of lesion formation, decreased magnitude and duration of viral shedding, and augmented post-Dryvax® vaccinia-specific CD8+ T cell responses and extracellular enveloped virus protein-specific antibody responses. MVA vaccination is safe and immunogenic and improves the safety and immunogenicity of subsequent Dryvax® vaccination supporting the potential for using MVA as a vaccine in the general population to improve immunity to orthopoxviruses. JF - Vaccine AU - Parrino, Janie AU - McCurdy, Lewis H AU - Larkin, Brenda D AU - Gordon, Ingelise J AU - Rucker, Steven E AU - Enama, Mary E AU - Koup, Richard A AU - Roederer, Mario AU - Bailer, Robert T AU - Moodie, Zoe AU - Gu, Lin AU - Yan, Lihan AU - Graham, Barney S AD - Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States, bgraham@nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 1513 EP - 1525 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 25 IS - 8 SN - 0264-410X, 0264-410X KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Smallpox KW - Orthopoxvirus KW - Vaccine KW - vaccines KW - Antibodies KW - Immunogenicity KW - Vaccinia KW - Lymphocytes T KW - Lesions KW - Vaccines KW - CD8 antigen KW - Turkey, Ankara KW - Vaccination KW - Side effects KW - V 22350:Immunology KW - F 06905:Vaccines KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20282778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Safety%2C+immunogenicity+and+efficacy+of+modified+vaccinia+Ankara+%28MVA%29+against+Dryvax+challenge+in+vaccinia-naive+and+vaccinia-immune+individuals&rft.au=Parrino%2C+Janie%3BMcCurdy%2C+Lewis+H%3BLarkin%2C+Brenda+D%3BGordon%2C+Ingelise+J%3BRucker%2C+Steven+E%3BEnama%2C+Mary+E%3BKoup%2C+Richard+A%3BRoederer%2C+Mario%3BBailer%2C+Robert+T%3BMoodie%2C+Zoe%3BGu%2C+Lin%3BYan%2C+Lihan%3BGraham%2C+Barney+S&rft.aulast=Parrino&rft.aufirst=Janie&rft.date=2007-02-01&rft.volume=25&rft.issue=8&rft.spage=1513&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2006.10.047 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Antibodies; Vaccinia; Immunogenicity; Lymphocytes T; CD8 antigen; Vaccines; Vaccination; vaccines; Lesions; Side effects; Turkey, Ankara DO - http://dx.doi.org/10.1016/j.vaccine.2006.10.047 ER - TY - JOUR T1 - Cryopreservation of porcine articular cartilage: MRI and biochemical results after different freezing protocols AN - 20267697; 7416278 AB - The objective of this study was to investigate the effects of cryopreservation on the components of articular cartilage (AC) matrix by utilizing magnetic resonance imaging (MRI) and biochemical assessments. Porcine AC (10mm osteochondral dowels) was collected into four groups - (1) phosphate buffered saline (PBS) control, (2) PBS snap frozen in liquid nitrogen, (3) slow-cooled in dimethyl sulfoxide (DMSO), and (4) slow cooled in PBS (in absence of DMSO). MRI results demonstrated three distinct zones in the cartilage. After exposure to ice formation during cryopreservation procedures, alterations in MRI determined matrix fixed charged density and magnetization transfer rate were noted. In addition, biochemical assays demonstrated significant alterations in chondroitin sulfate and hydroxyproline content over time without differences in hydration or DNA content. In conclusion, MRI was able to detect some changes in the intact cartilage matrix structure consistent with biochemical assessments after ice formation during cryopreservation of intact porcine AC. Furthermore, biochemical assessments supported some of these findings and changed significantly after incubating the cartilage matrix for 36-72h in PBS in terms of chondroitin sulfate and hydroxyproline content. JF - Cryobiology AU - Laouar, L AU - Fishbein, K AU - McGann, LE AU - Horton, W E AU - Spencer, R G AU - Jomha, N M AD - NIH/National Institute on Aging, Intramural Research Program, GRC 4D-08, 5600 Nathan Shock Drive Baltimore, MD 21224, USA, spencerri@grc.nia.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 36 EP - 43 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 54 IS - 1 SN - 0011-2240, 0011-2240 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Hydration KW - Ice KW - Hydroxyproline KW - Chondroitin sulfate KW - Magnetic resonance imaging KW - Freezing KW - Cryopreservation KW - Phosphate KW - DNA KW - Dimethyl sulfoxide KW - Cartilage (articular) KW - Nitrogen KW - Adenylate cyclase KW - W 30910:Imaging KW - T 2030:Cartilage and Cartilage Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20267697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cryobiology&rft.atitle=Cryopreservation+of+porcine+articular+cartilage%3A+MRI+and+biochemical+results+after+different+freezing+protocols&rft.au=Laouar%2C+L%3BFishbein%2C+K%3BMcGann%2C+LE%3BHorton%2C+W+E%3BSpencer%2C+R+G%3BJomha%2C+N+M&rft.aulast=Laouar&rft.aufirst=L&rft.date=2007-02-01&rft.volume=54&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Cryobiology&rft.issn=00112240&rft_id=info:doi/10.1016%2Fj.cryobiol.2006.10.193 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Hydration; Ice; Hydroxyproline; Chondroitin sulfate; Magnetic resonance imaging; Freezing; Cryopreservation; Phosphate; Dimethyl sulfoxide; DNA; Cartilage (articular); Adenylate cyclase; Nitrogen DO - http://dx.doi.org/10.1016/j.cryobiol.2006.10.193 ER - TY - JOUR T1 - The histone deacetylase inhibitor FK228 given prior to adenovirus infection can boost infection in melanoma xenograft model systems AN - 20227554; 7289995 AB - A major limitation of adenovirus type 5-mediated cancer gene therapy is the inefficient infection of many cancer cells. Previously, we showed that treatment with low doses of the histone deacetylase inhibitor FK228 (FR901228, depsipeptide) increased coxsackie adenovirus receptor (CAR) levels, histone H3 acetylation, and adenovirus infection efficiencies as measured by viral transgene expression in cancer cell lines but not in cultured normal cells. To evaluate FK228 in vivo, the effects of FK228 therapy in athymic mice bearing LOX IMVI or UACC-62 human melanoma xenografts were examined. Groups of mice were treated with FK228 using several dosing schedules and the differences between treated and control animals were determined. In mice with LOX IMVI xenografts (n = 6), maximum CAR induction was observed 24 h following a single FK228 dose of 3.6 mg/kg with a 13.6 plus or minus 4.3-fold (mean plus or minus SD) increase in human CAR mRNA as determined by semiquantitative reverse transcription-PCR analysis. By comparison, mouse CAR levels in liver, kidney, and lung from the same animals showed little to no change. Maximum CAR protein induction of 9.2 plus or minus 4.8-fold was achieved with these treatment conditions and was associated with increased histone H3 acetylation. Adenovirus carrying a green fluorescent protein (GFP) transgene (2 x 10 super(9) viral particles) was injected into the xenografts and GFP mRNA levels were determined. A 7.4 plus or minus 5.2-fold increase in GFP mRNA was found 24 h following adenovirus injection into optimally FK228-treated mice (n = 10). A 4-fold increase in GFP protein-positive cells was found following FK228 treatment. These studies suggest that FK228 treatment prior to adenovirus infection could increase the efficiency of adenovirus gene therapy in xenograft model systems. [Mol Cancer Ther 2007; 6(2):496-505] JF - Molecular Cancer Therapeutics AU - Goldsmith, Merrill E AU - Aguila, Alian AU - Steadman, Kenneth AU - Martinez, Alfredo AU - Steinberg, Seth M AU - Alley, Michael C AU - Waud, William R AU - Bates, Susan E AU - Fojo, Tito AD - Medical Oncology Branch, Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 496 EP - 505 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 6 IS - 2 SN - 1535-7163, 1535-7163 KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Histone deacetylase KW - CAR protein KW - Gene therapy KW - Adenovirus KW - Animal models KW - Green fluorescent protein KW - Infection KW - Cancer KW - Melanoma KW - Acetylation KW - Tumor cell lines KW - Lung KW - Liver KW - Kidney KW - Xenografts KW - Histone H3 KW - N 14820:DNA Metabolism & Structure KW - W 30915:Pharmaceuticals & Vaccines KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20227554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cancer+Therapeutics&rft.atitle=The+histone+deacetylase+inhibitor+FK228+given+prior+to+adenovirus+infection+can+boost+infection+in+melanoma+xenograft+model+systems&rft.au=Goldsmith%2C+Merrill+E%3BAguila%2C+Alian%3BSteadman%2C+Kenneth%3BMartinez%2C+Alfredo%3BSteinberg%2C+Seth+M%3BAlley%2C+Michael+C%3BWaud%2C+William+R%3BBates%2C+Susan+E%3BFojo%2C+Tito&rft.aulast=Goldsmith&rft.aufirst=Merrill&rft.date=2007-02-01&rft.volume=6&rft.issue=2&rft.spage=496&rft.isbn=&rft.btitle=&rft.title=Molecular+Cancer+Therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Histone deacetylase; CAR protein; Gene therapy; Green fluorescent protein; Animal models; Infection; Cancer; Melanoma; Acetylation; Tumor cell lines; Lung; Kidney; Liver; Xenografts; Histone H3; Adenovirus ER - TY - JOUR T1 - Evaluating microarrays using a semiparametric approach: Application to the central carbon metabolism of Escherichia coli BL21 and JM109 AN - 20079796; 7272640 AB - Escherichia coli K (JM109) and E. coli B (BL21) are strains used routinely for recombinant protein production. These two strains grow and respond differently to environmental factors such as glucose and oxygen concentration. The differences have been attributed to differential expression of individual genes that constitute certain metabolic pathways that are part of the central carbon metabolism. By implementing a semiparametric algorithm, which is based on a density ratio model, it was possible to compare and quantify the expression patterns of groups of genes involved in several central carbon metabolic pathways. The groups comprising the glyoxylate shunt, TCA cycle, fatty acid, and gluconeogenesis and anaplerotic pathways were expressed differently between the two strains, whereas no differences were apparent for the groups comprising either glycolysis or the pentose phosphate pathway. These results further characterized differences between the two E. coli strains and illustrated the potency of the semiparametric algorithm. JF - Genomics AU - Phue, J N AU - Kedem, B AU - Jaluria, P AU - Shiloach, J AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 14A, Room 170, 9000 Rockville Pike, Bethesda, MD 20892, USA, yossi@nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 300 EP - 305 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 89 IS - 2 SN - 0888-7543, 0888-7543 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Pentose phosphate pathway KW - Glucose KW - Algorithms KW - Environmental factors KW - Oxygen KW - Carbon KW - Shunts KW - Gluconeogenesis KW - Escherichia coli KW - Fatty acids KW - Metabolic pathways KW - Anaplerotic pathways KW - Tricarboxylic acid cycle KW - Glycolysis KW - Metabolism KW - W 30960:Bioinformatics & Computer Applications KW - G 07770:Bacteria KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20079796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genomics&rft.atitle=Evaluating+microarrays+using+a+semiparametric+approach%3A+Application+to+the+central+carbon+metabolism+of+Escherichia+coli+BL21+and+JM109&rft.au=Phue%2C+J+N%3BKedem%2C+B%3BJaluria%2C+P%3BShiloach%2C+J&rft.aulast=Phue&rft.aufirst=J&rft.date=2007-02-01&rft.volume=89&rft.issue=2&rft.spage=300&rft.isbn=&rft.btitle=&rft.title=Genomics&rft.issn=08887543&rft_id=info:doi/10.1016%2Fj.ygeno.2006.10.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Pentose phosphate pathway; Algorithms; Glucose; Environmental factors; Oxygen; Carbon; Shunts; Gluconeogenesis; Metabolic pathways; Fatty acids; Anaplerotic pathways; Tricarboxylic acid cycle; Glycolysis; Metabolism; Escherichia coli DO - http://dx.doi.org/10.1016/j.ygeno.2006.10.004 ER - TY - JOUR T1 - MR lymphangiography using dendrimer-based contrast agents: A comparison at 1.5T and 3.0T AN - 20030270; 8368401 AB - Most macromolecular contrast agents (CAs) show lower r1 and higher r2 relaxivities at 3.0T than at 1.5T. MR lymphangiography in mice using a macromolecular G6 dendrimer-based CA was serially performed and compared at both 1.5T and 3.0T. The r1 and r2 relaxivities of the G6 CA were 25 and 78/s/mM at 1.5T and 17 and 82/s/mM at 3.0T, respectively. The lymph node (LN)-to-fat ratios (LN signal intensity (SI)/fat SI) of T1-weighted 3D-fast spoiled gradient-echo (3D-FSPGR) were 3.2 - 0.4 (mean - standard deviation (SD)) at 1.5T and 2.7 - 0.3 at 3.0T (P = 0.021), and the LN-to-fat ratios of T2/T1-weighted 3D-fast imaging employing steady-state acquisition with phase cycling (3D-FIESTA-C) were 1.8 - 0.2 at 1.5T and 1.2 - 0.4 at 3.0T (P = 0.003). Although 3D-FSPGR successfully delineated the LNs at both 1.5T and 3.0T, 3D-FIESTA-C at 3.0T failed to visualize the LNs. Magn Reson Med 57:431-436, 2007. JF - Magnetic Resonance in Medicine AU - Hama, Yukihiro AU - Bernardo, Marcelino AU - Regino, Celeste A S AU - Koyama, Yoshinori AU - Brechbiel, Martin W AU - Krishna, Murali C AU - Choyke, Peter L AU - Kobayashi, Hisataka AD - Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA, Kobayash@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 431 EP - 436 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 57 IS - 2 SN - 0740-3194, 0740-3194 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Macromolecules KW - imaging KW - Lymph nodes KW - Lymphangiography KW - Standard deviation KW - Contrast media KW - N.M.R. KW - W 30910:Imaging KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20030270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=MR+lymphangiography+using+dendrimer-based+contrast+agents%3A+A+comparison+at+1.5T+and+3.0T&rft.au=Hama%2C+Yukihiro%3BBernardo%2C+Marcelino%3BRegino%2C+Celeste+A+S%3BKoyama%2C+Yoshinori%3BBrechbiel%2C+Martin+W%3BKrishna%2C+Murali+C%3BChoyke%2C+Peter+L%3BKobayashi%2C+Hisataka&rft.aulast=Hama&rft.aufirst=Yukihiro&rft.date=2007-02-01&rft.volume=57&rft.issue=2&rft.spage=431&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21126 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Contrast media; Macromolecules; Lymphangiography; N.M.R.; Lymph nodes; imaging; Standard deviation DO - http://dx.doi.org/10.1002/mrm.21126 ER - TY - JOUR T1 - Age-dependent accumulation of mtDNA mutations in murine hematopoietic stem cells is modulated by the nuclear genetic background AN - 19995218; 7287658 AB - Alterations in mitochondrial DNA (mtDNA) and consequent loss of mitochondrial function underlie the mitochondrial theory of aging. In this study, we systematically analyzed the mtDNA control region somatic mutation pattern in 2864 single hematopoietic stem cells (HSCs) and progenitors, isolated by flow cytometry sorting on Lin super(-)Kit super(+)CD34 super(-) parameters from young and old C57BL/6 (B6) and BALB/cBy (BALB) mice, to test the hypothesis that the accumulated mtDNA mutations in HSCs were strain-correlated and associated with HSC functional senescence during aging. An increased level of mtDNA mutations in single HSCs was observed in old B6 when compared with young B6 mice (P=0.003); in contrast, no significant age-dependent accumulation of mutations was observed in BALB mice (old versus young, P=0.202) and the level of mutations in both young and old BALB mice was close to that of old B6 mice (P>0.280). Cellular reactive oxygen species (ROS) in mouse HSCs could not be correlated with the level of mtDNA mutations in these cells, although B6 mice had a higher proportion of ROS super(-) cells when compared with the BALB mice. Propagation assays of single HSCs showed B6 cells form larger colonies compared with cells from BALB mice, irrespective of age and mtDNA mutation load. We infer from our data that age-related mtDNA somatic mutation accumulation in mouse HSCs is influenced by the nuclear genetic background and that these mutations may not obviously correlate to either cellular ROS content or HSC senescence. JF - Human Molecular Genetics AU - Yao, Yong-Gang AU - Ellison, Felicia M AU - McCoy, JPhilip AU - Chen, Jichun AU - Young, Neal S AD - Hematology Branch and. Flow Cytometry Core Facility, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1202, USA Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 286 EP - 294 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 16 IS - 3 SN - 0964-6906, 0964-6906 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Age KW - Data processing KW - Aging KW - Mitochondria KW - Flow cytometry KW - Mitochondrial DNA KW - Stem cells KW - Colonies KW - Reactive oxygen species KW - Hemopoiesis KW - Senescence KW - Mutation KW - G 07870:Mammals KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19995218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Molecular+Genetics&rft.atitle=Age-dependent+accumulation+of+mtDNA+mutations+in+murine+hematopoietic+stem+cells+is+modulated+by+the+nuclear+genetic+background&rft.au=Yao%2C+Yong-Gang%3BEllison%2C+Felicia+M%3BMcCoy%2C+JPhilip%3BChen%2C+Jichun%3BYoung%2C+Neal+S&rft.aulast=Yao&rft.aufirst=Yong-Gang&rft.date=2007-02-01&rft.volume=16&rft.issue=3&rft.spage=286&rft.isbn=&rft.btitle=&rft.title=Human+Molecular+Genetics&rft.issn=09646906&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Age; Colonies; Stem cells; Mitochondrial DNA; Data processing; Reactive oxygen species; Aging; Hemopoiesis; Mitochondria; Senescence; Mutation ER - TY - JOUR T1 - Self-Renewing and Differentiating Properties of Cortical Neural Stem Cells Are Selectively Regulated by Basic Fibroblast Growth Factor (FGF) Signaling via Specific FGF Receptors AN - 19990484; 7289418 AB - Developmental processes mediating the initiation of lineage commitment from self-renewing neural stem cells (NSCs) remain mostly unclear because of the persisting ambiguity in identifying true NSCs from proliferative lineage-restricted progenitors (LRPs), which are directly or indirectly derived from NSCs. Our multilineage immunohistochemical analyses of early embryonic rat telencephalon at the onset of neurogenesis revealed clear dorsoventral gradients in the emergence of two types of neuronal progenitors (NPs) from multilineage-negative NSCs. Enumeration of NSCs using comprehensive flow cytometric analysis demonstrated that their precipitous decline in vivo involved both active differentiation into NPs and an increased propensity toward apoptosis. Both processes paralleled the dorsoventral changes in fibroblast growth factor receptor (FGFR) expressions. NSCs residing in the dorsal telencephalon coexpressed FGFR1 and FGFR3, whereas those residing in the ventral telencephalon also expressed FGFR2. NSCs exposed to basic fibroblast growth factor (bFGF) in vitro generated four stereotypical clonal expansion states: efficiently self-renewing, inefficiently self-renewing limited by apoptosis, exclusively neurogenic, and multipotential, generating up to five types of LRPs. The plasticity among these expansion states depended on ambient [bFGF], telencephalic developmental stage, and differential activation/inactivation of specific FGFRs. Coactivation of FGFR1 and FGFR3 promoted symmetrical divisions of NSCs (self-renewal), whereas inactivation of either triggered asymmetrical divisions and neurogenesis from these cells. Developmental upregulation of FGFR2 expression correlated with a shift of NSCs into a multipotential state or apoptosis. These results provide new insights regarding the roles of FGFRs in diversification of NSC properties and initiation of neural lineage-restricted differentiation. JF - Journal of Neuroscience AU - Maric, Dragan AU - Fiorio Pla, Alessandra AU - Chang, Yoong Hee AU - Barker, Jeffery L AD - Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, Laboratory of Physiology, Department of Human and Animal Biology, University of Torino, 10123 Torino, Italy, and Nanostructured Interfaces and Surfaces Centre of Excellence, 10125 Torino, Italy Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 1836 EP - 1852 PB - Society for Neuroscience, 11 Dupont Circle, N.W. Suite 500 Washington DC 20036 USA, [mailto:info@sfn.org], [URL:http://apu.sfn.org/] VL - 27 IS - 8 SN - 0270-6474, 0270-6474 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Fibroblast growth factor receptors KW - Plasticity (developmental) KW - Apoptosis KW - Receptor mechanisms KW - Fibroblast growth factor receptor 2 KW - Fibroblast growth factor receptor 1 KW - Developmental stages KW - Flow cytometry KW - Differentiation KW - Neurogenesis KW - Nervous system KW - Cortex KW - Fibroblast growth factor KW - Embryos KW - Telencephalon KW - Fibroblast growth factor 2 KW - Neural stem cells KW - Signal transduction KW - N3 11003:Developmental neuroscience KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19990484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=Self-Renewing+and+Differentiating+Properties+of+Cortical+Neural+Stem+Cells+Are+Selectively+Regulated+by+Basic+Fibroblast+Growth+Factor+%28FGF%29+Signaling+via+Specific+FGF+Receptors&rft.au=Maric%2C+Dragan%3BFiorio+Pla%2C+Alessandra%3BChang%2C+Yoong+Hee%3BBarker%2C+Jeffery+L&rft.aulast=Maric&rft.aufirst=Dragan&rft.date=2007-02-01&rft.volume=27&rft.issue=8&rft.spage=1836&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Fibroblast growth factor receptors; Plasticity (developmental); Apoptosis; Fibroblast growth factor receptor 2; Receptor mechanisms; Fibroblast growth factor receptor 1; Developmental stages; Flow cytometry; Differentiation; Nervous system; Neurogenesis; Cortex; Fibroblast growth factor; Telencephalon; Embryos; Fibroblast growth factor 2; Neural stem cells; Signal transduction ER - TY - JOUR T1 - Pharmacokinetics and Safety of Indinavir in Human Immunodeficiency Virus-Infected Pregnant Women AN - 19986147; 7248876 AB - Human immunodeficiency virus-infected women (n = 16) received indinavir (800 mg three times a day) plus zidovudine plus lamivudine from 14 to 28 weeks of gestation to 12 weeks postpartum. Two women and eight infants experienced grade 3 or 4 toxicities that were possibly treatment related. Indinavir area under the plasma concentration-time curve was 68% lower antepartum versus postpartum, suggesting increased intestinal and/or hepatic CYP3A activity during pregnancy. JF - Antimicrobial Agents & Chemotherapy AU - Unadkat, Jashvant D AU - Wara, Diane W AU - Hughes, Michael D AU - Mathias, Anita A AU - Holland, Diane T AU - Paul, Mary E AU - Connor, James AU - Huang, Sharon AU - Nguyen, Bach-Yen AU - Watts, DHeather AU - Mofenson, Lynne M AU - Smith, Elizabeth AU - Deutsch, Paul AU - Kaiser, Kathleen A AU - Tuomala, Ruth E AD - Department of Pharmaceutics, University of Washington, Seattle, Washington. Department of Pediatrics, University of California San Francisco, San Francisco, California. Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts. Division of Clinical Pharmacology and Developmental Therapeutics, University of California, San Diego, California. Baylor College of Medicine, Houston, Texas. Merck Research Laboratories, West Point, Pennsylvania. Pediatric Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, Bethesda, Maryland. Pediatric Medical Branch, Therapeutics Research Plan, Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland. Frontier Science and Technology Research Foundation. Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 783 EP - 786 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 51 IS - 2 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Indinavir KW - Immunodeficiency KW - Zidovudine KW - Lamivudine KW - Toxicity KW - Pharmacokinetics KW - Antimicrobial agents KW - Pregnancy KW - Postpartum KW - Gestation KW - Intestine KW - Liver KW - Infants KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19986147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Pharmacokinetics+and+Safety+of+Indinavir+in+Human+Immunodeficiency+Virus-Infected+Pregnant+Women&rft.au=Unadkat%2C+Jashvant+D%3BWara%2C+Diane+W%3BHughes%2C+Michael+D%3BMathias%2C+Anita+A%3BHolland%2C+Diane+T%3BPaul%2C+Mary+E%3BConnor%2C+James%3BHuang%2C+Sharon%3BNguyen%2C+Bach-Yen%3BWatts%2C+DHeather%3BMofenson%2C+Lynne+M%3BSmith%2C+Elizabeth%3BDeutsch%2C+Paul%3BKaiser%2C+Kathleen+A%3BTuomala%2C+Ruth+E&rft.aulast=Unadkat&rft.aufirst=Jashvant&rft.date=2007-02-01&rft.volume=51&rft.issue=2&rft.spage=783&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Indinavir; Immunodeficiency; Lamivudine; Zidovudine; Toxicity; Pharmacokinetics; Pregnancy; Antimicrobial agents; Postpartum; Gestation; Liver; Intestine; Infants ER - TY - JOUR T1 - Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 super(+) T cells AN - 19981452; 7485620 AB - Depleting host immune elements with nonmyeloablative regimens prior to the adoptive transfer of tumor-specific CD8 super(+) T cells significantly enhances tumor treatment. In the current study, superior antitumor efficacy was achieved by further increasing the intensity of lymphodepletion to a level that required HSC transplantation. Surprisingly, the HSC transplant and not the increased lymphodepletion caused a robust expansion of adoptively transferred tumor-specific CD8 super(+) T cells. The HSC-driven cell expansion of effector, but not of naive, CD8 super(+) T cells was independent of in vivo restimulation by MHC class I-expressing APCs. Simultaneously, HSCs also facilitated the reconstitution of the host lymphoid compartment, including inhibitory elements, not merely via the production of progeny cells but by enhancing the expansion of cells that had survived lymphodepletion. Profound lymphodepletion, by myeloablation or by genetic means, focused the nonspecific HSC boost preferentially toward the transferred tumor-specific T cells, leading to successful tumor treatment. These findings indicate that CD8 super(+) T cell-mediated tumor responses can be efficiently driven by HSCs in the myeloablative setting and have substantial implications for the design of new antitumor immunotherapies. JF - Journal of Clinical Investigation AU - Wrzesinski, Claudia AU - Paulos, Chrystal M AU - Gattinoni, Luca AU - Palmer, Douglas C AU - Kaiser, Andrew AU - Yu, Zhiya AU - Rosenberg, Steven A AU - Restifo, Nicholas P AD - National Cancer Institute, NIH, Bethesda, Maryland, USA., wrzesinc@mail.nih.gov(C.Wrzesinski). Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 492 EP - 501 PB - American Society for Clinical Investigation, 35 Research Drive, Suite 300 Ann Arbor MI 48103 USA, [mailto:asci@the-jci-org], [URL:http://www.asci-jci.org] VL - 117 IS - 2 SN - 0021-9738, 0021-9738 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Stem cells KW - adenomatous polyposis coli KW - Immunotherapy KW - Lymphocytes T KW - Adoptive transfer KW - Major histocompatibility complex KW - Progeny KW - CD8 antigen KW - Tumors KW - Antigen-presenting cells KW - Antitumor activity KW - F 06915:Cancer Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19981452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Investigation&rft.atitle=Hematopoietic+stem+cells+promote+the+expansion+and+function+of+adoptively+transferred+antitumor+CD8+super%28%2B%29+T+cells&rft.au=Wrzesinski%2C+Claudia%3BPaulos%2C+Chrystal+M%3BGattinoni%2C+Luca%3BPalmer%2C+Douglas+C%3BKaiser%2C+Andrew%3BYu%2C+Zhiya%3BRosenberg%2C+Steven+A%3BRestifo%2C+Nicholas+P&rft.aulast=Wrzesinski&rft.aufirst=Claudia&rft.date=2007-02-01&rft.volume=117&rft.issue=2&rft.spage=492&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Investigation&rft.issn=00219738&rft_id=info:doi/10.1172%2FJCI30414 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Stem cells; adenomatous polyposis coli; Immunotherapy; Adoptive transfer; Lymphocytes T; Major histocompatibility complex; Progeny; Antigen-presenting cells; Tumors; CD8 antigen; Antitumor activity DO - http://dx.doi.org/10.1172/JCI30414 ER - TY - JOUR T1 - Combination Therapy with a Long-Acting [beta]-Agonist and a Leukotriene Antagonist in Moderate Asthma AN - 199604112; 16973987 AB - Long-acting beta-agonists (LABAs) and inhaled corticosteroids administered together appear to be complementary in terms of effects on asthma control. The elements of asthma control achieved by LABAs (improved lung function) and leukotriene receptor antagonists (LTRAs; protection against exacerbations) may be complementary as well. We sought to determine whether the combination of the LTRA montelukast and the LABA salmeterol could provide an effective therapeutic strategy for asthma. In a randomized, placebo-controlled, crossover study of 192 subjects with moderate asthma, we compared the clinical efficacy of regular treatment over 14 weeks with the combination of montelukast and salmeterol to that with the combination of beclomethasone and salmeterol in moderate asthma. The primary efficacy outcome was time to treatment failure. Three months after the randomization of the last subject, the Data and Safety Monitoring Board determined that the primary research question had been answered and terminated the trial. The combination of montelukast and salmeterol was inferior to the combination of beclomethasone and salmeterol as judged by protection against asthma treatment failures (p = 0.0008), lung function (26 L/min difference in a.m. peak expiratory flow rate, p = 0.011), asthma control score (0.22 difference in Asthma Control Questionnaire score, p = 0.038), and markers of inflammation and airway reactivity. Patients with moderate asthma similar to those we studied should not substitute the combination of an LTRA and an LABA for the combination of inhaled corticosteroid and an LABA. JF - American Journal of Respiratory and Critical Care Medicine AU - Deykin, Aaron AU - Wechsler, Michael E AU - Boushey, Homer A AU - Chinchilli, Vernon M AU - et al Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 228 EP - 34 CY - New York PB - American Thoracic Society VL - 175 IS - 3 SN - 1073449X KW - Medical Sciences--Respiratory Diseases KW - Acetates KW - Adrenal Cortex Hormones KW - Adrenergic beta-Agonists KW - Anti-Asthmatic Agents KW - Leukotriene Antagonists KW - Placebos KW - Quinolines KW - salmeterol KW - montelukast KW - Albuterol KW - Double-Blind Method KW - Combined Modality Therapy KW - Humans KW - Aged KW - Albuterol -- therapeutic use KW - Adrenal Cortex Hormones -- therapeutic use KW - Adrenal Cortex Hormones -- administration & dosage KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Administration, Inhalation KW - Adolescent KW - Female KW - Male KW - Asthma -- drug therapy KW - Albuterol -- analogs & derivatives KW - Quinolines -- therapeutic use KW - Acetates -- therapeutic use KW - Anti-Asthmatic Agents -- therapeutic use KW - Leukotriene Antagonists -- therapeutic use KW - Adrenergic beta-Agonists -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/199604112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Combination+Therapy+with+a+Long-Acting+%5Bbeta%5D-Agonist+and+a+Leukotriene+Antagonist+in+Moderate+Asthma&rft.au=Deykin%2C+Aaron%3BWechsler%2C+Michael+E%3BBoushey%2C+Homer+A%3BChinchilli%2C+Vernon+M%3Bet+al&rft.aulast=Deykin&rft.aufirst=Aaron&rft.date=2007-02-01&rft.volume=175&rft.issue=3&rft.spage=228&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Thoracic Society Feb 1, 2007 N1 - Last updated - 2017-01-07 ER - TY - JOUR T1 - Higher Urine Nitric Oxide Is Associated with Improved Outcomes in Patients with Acute Lung Injury AN - 199603576; 17082495 AB - Nitrogen oxide (NO) species are markers for oxidative stress that may be pathogenic in acute lung injury (ALI). We tested two hypotheses in patients with ALI: (1) higher levels of urine NO would be associated with worse clinical outcomes, and (2) ventilation with lower VT would reduce urine NO as a result of less stretch injury. Urine NO levels were measured by chemiluminescence in 566 patients enrolled in the National Heart Lung and Blood Institute Acute Respiratory Distress Syndrome Network trial of 6 ml/kg versus 12 ml/kg VT ventilation. The data were expressed corrected and uncorrected for urine creatinine (Cr). Higher baseline levels of urine NO to Cr were associated with lower mortality (odds ratio, 0.43 per log(10) increase in the ratio), more ventilator-free days (mean increase, 1.9 d), and more organ-failure-free days (mean increase, 2.3 d) on multivariate analysis (p < 0.05 for all analyses). Similar results were obtained using urine NO alone. NO to Cr levels were higher on Day 3 in the 6 ml/kg than in the 12 ml/kg VT group (p = 0.04). Contrary to our hypothesis, higher urine NO was associated with improved outcomes in ALI at baseline and after treatment with the 6 ml/kg VT strategy. Higher endogenous NO may reflect less severe lung injury and better preservation of the pulmonary and systemic endothelium or may serve a protective function in patients with ALI. JF - American Journal of Respiratory and Critical Care Medicine AU - McClintock, Dana E AU - Ware, Lorraine B AU - Eisner, Mark D AU - Wickersham, Nancy AU - et al Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 256 EP - 62 CY - New York PB - American Thoracic Society VL - 175 IS - 3 SN - 1073449X KW - Medical Sciences--Respiratory Diseases KW - Biological Markers KW - Nitric Oxide KW - Creatinine KW - Severity of Illness Index KW - Creatinine -- urine KW - Disease Susceptibility KW - Humans KW - Prognosis KW - Aged KW - Outcome Assessment (Health Care) KW - Multivariate Analysis KW - Respiratory Distress Syndrome, Adult -- urine KW - Adult KW - Oxidative Stress KW - Middle Aged KW - Female KW - Male KW - Respiratory Distress Syndrome, Adult -- mortality KW - Nitric Oxide -- urine KW - Respiratory Distress Syndrome, Adult -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/199603576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Higher+Urine+Nitric+Oxide+Is+Associated+with+Improved+Outcomes+in+Patients+with+Acute+Lung+Injury&rft.au=McClintock%2C+Dana+E%3BWare%2C+Lorraine+B%3BEisner%2C+Mark+D%3BWickersham%2C+Nancy%3Bet+al&rft.aulast=McClintock&rft.aufirst=Dana&rft.date=2007-02-01&rft.volume=175&rft.issue=3&rft.spage=256&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Thoracic Society Feb 1, 2007 N1 - Last updated - 2017-01-07 ER - TY - JOUR T1 - Inhibition of Metalloprotease Botulinum Serotype A from a Pseudo-peptide Binding Mode to a Small Molecule That Is Active in Primary Neurons AN - 19862688; 7288468 AB - An efficient research strategy integrating empirically guided, structure-based modeling and chemoinformatics was used to discover potent small molecule inhibitors of the botulinum neurotoxin serotype A light chain. First, a modeled binding mode for inhibitor 2-mercapto-3-phenylpropionyl-RATKML (K sub(i) = 330 nM) was generated, and required the use of a molecular dynamic conformer of the enzyme displaying the reorientation of surface loops bordering the substrate binding cleft. These flexible loops are conformationally variable in x-ray crystal structures, and the model predicted that they were pivotal for providing complementary binding surfaces and solvent shielding for the pseudo-peptide. The docked conformation of 2-mercapto-3-phenylpropionyl-RATKML was then used to refine our pharmacophore for botulinum serotype A light chain inhibition. Data base search queries derived from the pharmacophore were employed to mine small molecule (non-peptidic) inhibitors from the National Cancer Institute's Open Repository. Four of the inhibitors possess K sub(i) values ranging from 3.0 to 10.0 mu M. Of these, NSC 240898 is a promising lead for therapeutic development, as it readily enters neurons, exhibits no neuronal toxicity, and elicits dose-dependent protection of synaptosomal-associated protein (of 25 kDa) in a primary culture of embryonic chicken neurons. Isothermal titration calorimetry showed that the interaction between NSC 240898 and the botulinum A light chain is largely entropy-driven, and occurs with a 1:1 stoichiometry and a dissociation constant of 4.6 mu M. JF - Journal of Biological Chemistry AU - Burnett, James C AU - Ruthel, Gordon AU - Stegmann, Christian M AU - Panchal, Rekha G AU - Nguyen, Tam L AU - Hermone, Ann R AU - Stafford, Robert G AU - Lane, Douglas J AU - Kenny, Tara A AU - McGrath, Connor F AU - Wipf, Peter AU - Stahl, Andrea M AU - Schmidt, James J AU - Gussio, Rick AU - Brunger, Axel T AU - Bavari, Sina AD - Target Structure-based Drug Discovery Group, SAIC-Frederick, Inc., and the Information Technology Branch, Developmental Therapeutics Program, National Cancer Institute-Frederick, Frederick, Maryland 21702, the United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702, the Howard Hughes Medical Institute (HHMI) and Departments of Molecular and Cellular Physiology, Neurology and Neurological Sciences, and the Stanford Synchrotron Radiation Laboratory, Stanford University, School of Medicine, Stanford, California 94305, and the Combinatorial Chemistry Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15260 Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 5004 EP - 5014 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 7 SN - 0021-9258, 0021-9258 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Light chains KW - Serotypes KW - Solvents KW - Enzymes KW - Botulinum toxin type A KW - Mines KW - Cancer KW - Metalloproteinase KW - Databases KW - Embryogenesis KW - Ionizing radiation KW - Neurons KW - Titration KW - Neurotoxicity KW - Crystal structure KW - Calorimetry KW - Embryos KW - Botulinum toxin KW - pharmacophores KW - N3 11008:Neurochemistry KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19862688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Inhibition+of+Metalloprotease+Botulinum+Serotype+A+from+a+Pseudo-peptide+Binding+Mode+to+a+Small+Molecule+That+Is+Active+in+Primary+Neurons&rft.au=Burnett%2C+James+C%3BRuthel%2C+Gordon%3BStegmann%2C+Christian+M%3BPanchal%2C+Rekha+G%3BNguyen%2C+Tam+L%3BHermone%2C+Ann+R%3BStafford%2C+Robert+G%3BLane%2C+Douglas+J%3BKenny%2C+Tara+A%3BMcGrath%2C+Connor+F%3BWipf%2C+Peter%3BStahl%2C+Andrea+M%3BSchmidt%2C+James+J%3BGussio%2C+Rick%3BBrunger%2C+Axel+T%3BBavari%2C+Sina&rft.aulast=Burnett&rft.aufirst=James&rft.date=2007-02-01&rft.volume=282&rft.issue=7&rft.spage=5004&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Light chains; Serotypes; Solvents; Enzymes; Botulinum toxin type A; Mines; Cancer; Metalloproteinase; Databases; Embryogenesis; Neurons; Ionizing radiation; Neurotoxicity; Titration; Crystal structure; Calorimetry; Embryos; Botulinum toxin; pharmacophores ER - TY - JOUR T1 - The Nuclease A-Inhibitor Complex Is Characterized by a Novel Metal Ion Bridge AN - 19856392; 7288542 AB - Nonspecific, extracellular nucleases have received enhanced attention recently as a consequence of the critical role that these enzymes can play in infectivity by overcoming the host neutrophil defense system. The activity of the cyanobacterial nuclease NucA, a member of the beta beta alpha Me superfamily, is controlled by the specific nuclease inhibitor, NuiA. Here we report the 2.3-Aa resolution crystal structure of the NucA-NuiA complex, showing that NucA inhibition by NuiA involves an unusual divalent metal ion bridge that connects the nuclease with its inhibitor. The C-terminal Thr-135 sub(NuiA) hydroxyl oxygen is directly coordinated with the catalytic Mg super(2+) of the nuclease active site, and Glu-24 sub(NuiA) also extends into the active site, mimicking the charge of a scissile phosphate. NuiA residues Asp-75 and Trp-76 form a second interaction site, contributing to the strength and specificity of the interaction. The crystallographically defined interface is shown to be consistent with results of studies using site-directed NuiA mutants. This mode of inhibition differs dramatically from the exosite mechanism of inhibition seen with the DNase colicins E7/E9 and from other nuclease-inhibitor complexes that have been studied. The structure of this complex provides valuable insights for the development of inhibitors for related nonspecific nucleases that share the DRGH active site motif such as the Streptococcus pneumoniae nuclease EndA, which mediates infectivity of this pathogen, and mitochondrial EndoG, which is involved in recombination and apoptosis. JF - Journal of Biological Chemistry AU - Ghosh, Mahua AU - Meiss, Gregor AU - Pingoud, Alfred M AU - London, Robert E AU - Pedersen, Lars C AD - Laboratory of Structural Biology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709 and Institut fuer Biochemie (FB 08), Justus-Liebig-Universitaet, Heinrich-Buff-Ring 58, D-35392 Giessen, Germany Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 5682 EP - 5690 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 8 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Mimicry KW - Metals KW - Apoptosis KW - colicin E7 KW - Leukocytes (neutrophilic) KW - Enzymes KW - Mitochondria KW - Nuclease KW - Pathogens KW - Nuia KW - Oxygen KW - Recombination KW - Streptococcus pneumoniae KW - Infectivity KW - Phosphate KW - Crystal structure KW - Deoxyribonuclease KW - Magnesium KW - J 02310:Genetics & Taxonomy KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19856392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=The+Nuclease+A-Inhibitor+Complex+Is+Characterized+by+a+Novel+Metal+Ion+Bridge&rft.au=Ghosh%2C+Mahua%3BMeiss%2C+Gregor%3BPingoud%2C+Alfred+M%3BLondon%2C+Robert+E%3BPedersen%2C+Lars+C&rft.aulast=Ghosh&rft.aufirst=Mahua&rft.date=2007-02-01&rft.volume=282&rft.issue=8&rft.spage=5682&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Metals; Mimicry; Apoptosis; colicin E7; Leukocytes (neutrophilic); Nuclease; Mitochondria; Enzymes; Pathogens; Recombination; Oxygen; Infectivity; Phosphate; Crystal structure; Deoxyribonuclease; Magnesium; Streptococcus pneumoniae; Nuia ER - TY - JOUR T1 - Characterization, Kinetics, and Crystal Structures of Fructose-1,6-bisphosphate Aldolase from the Human Parasite, Giardia lamblia AN - 19856347; 7288453 AB - Class I and class II fructose-1,6-bisphosphate aldolases (FBPA), glycolytic pathway enzymes, exhibit no amino acid sequence homology and utilize two different catalytic mechanisms. The mammalian class I FBPA employs a Schiff base mechanism, whereas the human parasitic protozoan Giardia lamblia class II FBPA is a zinc-dependent enzyme. In this study, we have explored the potential exploitation of the Giardia FBPA as a drug target. First, synthesis of FBPA was demonstrated in Giardia trophozoites by using an antibody-based fluorescence assay. Second, inhibition of FBPA gene transcription in Giardia trophozoites suggested that the enzyme is necessary for the survival of the organism under optimal laboratory growth conditions. Third, two crystal structures of FBPA in complex with the transition state analog phosphoglycolohydroxamate (PGH) show that the enzyme is homodimeric and that its active site contains a zinc ion. In one crystal form, each subunit contains PGH, which is coordinated to the zinc ion through the hydroxamic acid hydroxyl and carbonyl oxygen atoms. The second crystal form contains PGH only in one subunit and the active site of the second subunit is unoccupied. Inspection of the two states of the enzyme revealed that it undergoes a conformational transition upon ligand binding. The enzyme cleaves D-fructose-1,6-bisphosphate but not D-tagatose-1,6-bisphosphate, which is a tight binding competitive inhibitor. The essential role of the active site residue Asp-83 in catalysis was demonstrated by amino acid replacement. Determinants of catalysis and substrate recognition, derived from comparison of the G. lamblia FBPA structure with Escherichia coli FBPA and with a closely related enzyme, E. coli tagatose-1,6-bisphosphate aldolase (TBPA), are described. JF - Journal of Biological Chemistry AU - Galkin, Andrey AU - Kulakova, Liudmila AU - Melamud, Eugene AU - Li, Ling AU - Wu, Chun AU - Mariano, Patrick AU - Dunaway-Mariano, Debra AU - Nash, Theodore E AU - Herzberg, Osnat AD - Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, the Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131, and Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 4859 EP - 4867 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 7 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Parasites KW - Fluorescence KW - Growth conditions KW - Fructose-1,6-diphosphate KW - Giardia lamblia KW - Enzymes KW - Transcription KW - Survival KW - Crystals KW - Hydroxamic acid KW - Oxygen KW - Homology KW - Kinetics KW - Zinc KW - Escherichia coli KW - Crystal structure KW - Drugs KW - Glycolysis KW - carbonyls KW - Amino acid sequence KW - Catalysis KW - Trophozoites KW - K 03330:Biochemistry KW - N 14815:Nucleotide Sequence KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19856347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Characterization%2C+Kinetics%2C+and+Crystal+Structures+of+Fructose-1%2C6-bisphosphate+Aldolase+from+the+Human+Parasite%2C+Giardia+lamblia&rft.au=Galkin%2C+Andrey%3BKulakova%2C+Liudmila%3BMelamud%2C+Eugene%3BLi%2C+Ling%3BWu%2C+Chun%3BMariano%2C+Patrick%3BDunaway-Mariano%2C+Debra%3BNash%2C+Theodore+E%3BHerzberg%2C+Osnat&rft.aulast=Galkin&rft.aufirst=Andrey&rft.date=2007-02-01&rft.volume=282&rft.issue=7&rft.spage=4859&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Parasites; Fluorescence; Fructose-1,6-diphosphate; Growth conditions; Survival; Transcription; Enzymes; Crystals; Hydroxamic acid; Oxygen; Homology; Kinetics; Zinc; Crystal structure; carbonyls; Glycolysis; Drugs; Trophozoites; Catalysis; Amino acid sequence; Giardia lamblia; Escherichia coli ER - TY - JOUR T1 - Pathogenesis of Aspergillus fumigatus and the Kinetics of Galactomannan in an In Vitro Model of Early Invasive Pulmonary Aspergillosis: Implications for Antifungal Therapy AN - 19850040; 7265301 AB - Background. Little is known about the pathogenesis of invasive pulmonary aspergillosis and the relationship between the kinetics of diagnostic markers and the outcome of antifungal therapy. Methods. An in vitro model of the human alveolus, consisting of a bilayer of human alveolar epithelial and endothelial cells, was developed. An Aspergillus fumigatus strain expressing green fluorescent protein was used. Invasion of the cell bilayer was studied using confocal and electron microscopy. The kinetics of culture, polymerase chain reaction, and galactomannan were determined. Galactomannan was used to measure the antifungal effect of macrophages and amphotericin B. A mathematical model was developed, and results were bridged to humans. Results. A. fumigatus penetrated the cellular bilayer 14-16 h after inoculation. Galactomannan levels were inextricably tied to fungal invasion and were a robust measure of the antifungal effect of macrophages and amphotericin B. Neither amphotericin nor macrophages alone was able to suppress the growth of A. fumigatus; rather, the combination was required. Monte Carlo simulations showed that human dosages of amphotericin B of at least 0.6 mg/kg were required to achieve adequate drug exposure. Conclusions. This model provides a strategy by which relationships among pathogenesis, immunological effectors, and antifungal drug therapy for invasive pulmonary aspergillosis may be further understood. JF - Journal of Infectious Diseases AU - Hope, W W AU - Kruhlak, MJ AU - Lyman, CA AU - Petraitiene, R AU - Petraitis, V AU - Francesconi, A AU - Kasai, M AU - Mickiene, D AU - Sein, T AU - Peter, J AU - Kelaher, A M AU - Hughes, JE AU - Cotton, M P AU - Cotten, C J AD - Immunocompromised Host Section, Pediatric Oncology Branch, and Experimental Immunology Branch, National Cancer Institute, and Veterinary Resources Program, Office of Research Services, National Institutes of Health, Bethesda, SAIC-Frederick, Inc., Frederick, and Department of Biology, University of Maryland, College Park, Maryland, USA Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 455 EP - 466 VL - 195 IS - 3 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Monte Carlo simulation KW - Macrophages KW - Amphotericin B KW - Mathematical models KW - Green fluorescent protein KW - Cell culture KW - Aspergillosis KW - Alveoli KW - Endothelial cells KW - Lung KW - Aspergillus fumigatus KW - Kinetics KW - Inoculation KW - Polymerase chain reaction KW - Drugs KW - Electron microscopy KW - K 03410:Animal Diseases KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19850040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Pathogenesis+of+Aspergillus+fumigatus+and+the+Kinetics+of+Galactomannan+in+an+In+Vitro+Model+of+Early+Invasive+Pulmonary+Aspergillosis%3A+Implications+for+Antifungal+Therapy&rft.au=Hope%2C+W+W%3BKruhlak%2C+MJ%3BLyman%2C+CA%3BPetraitiene%2C+R%3BPetraitis%2C+V%3BFrancesconi%2C+A%3BKasai%2C+M%3BMickiene%2C+D%3BSein%2C+T%3BPeter%2C+J%3BKelaher%2C+A+M%3BHughes%2C+JE%3BCotton%2C+M+P%3BCotten%2C+C+J&rft.aulast=Hope&rft.aufirst=W&rft.date=2007-02-01&rft.volume=195&rft.issue=3&rft.spage=455&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Macrophages; Monte Carlo simulation; Amphotericin B; Mathematical models; Green fluorescent protein; Aspergillosis; Cell culture; Alveoli; Endothelial cells; Lung; Kinetics; Inoculation; Polymerase chain reaction; Drugs; Electron microscopy; Aspergillus fumigatus ER - TY - JOUR T1 - The Pregnane X Receptor Gene-Humanized Mouse: A Model for Investigating Drug-Drug Interactions Mediated by Cytochromes P450 3A AN - 19848698; 7251868 AB - The most common clinical implication for the activation of the human pregnane X receptor (PXR) is the occurrence of drug-drug interactions mediated by up-regulated cytochromes P450 3A (CYP3A) isozymes. Typical rodent models do not predict drug-drug interactions mediated by human PXR because of species differences in response to PXR ligands. In the current study, a PXR-humanized mouse model was generated by bacterial artificial chromosome (BAC) transgenesis in Pxr-null mice using a BAC clone containing the complete human PXR gene and 5'- and 3'-flanking sequences. In this PXR-humanized mouse model, PXR is selectively expressed in the liver and intestine, the same tissue expression pattern as CYP3A. Treatment of PXR-humanized mice with the PXR ligands mimicked the human response, since both hepatic and intestinal CYP3As were strongly induced by rifampicin, a human-specific PXR ligand, but not by pregnenolone 16 alpha -carbonitrile, a rodent-specific PXR ligand. In rifampicin-pretreated PXR-humanized mice, an similar to 60% decrease was observed for both the maximal midazolam serum concentration (C sub(max)) and the area under the concentration-time curve, as a result of a 3-fold increase in midazolam 1'-hydroxylation. These results illustrate the potential utility of the PXR-humanized mice in the investigation of drug-drug interactions mediated by CYP3A and suggest that the PXR-humanized mouse model would be an appropriate in vivo tool for evaluation of the overall pharmacokinetic consequences of human PXR activation by drugs. JF - Drug Metabolism and Disposition AU - Ma, Xiaochao AU - Shah, Yatrik AU - Cheung, Connie AU - Guo, Grace L AU - Feigenbaum, Lionel AU - Krausz, Kristopher W AU - Idle, Jeffrey R AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (X.M., Y.S., C.C., K.W.K., F.J.G.) Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 194 EP - 200 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 USA, [URL:http://www.lww.com/] VL - 35 IS - 2 SN - 0090-9556, 0090-9556 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Toxicology Abstracts KW - Animal models KW - Pharmacokinetics KW - Bacterial artificial chromosomes KW - midazolam KW - Rifampin KW - Liver KW - Intestine KW - Pregnenolone KW - Isoenzymes KW - Cytochrome P450 KW - pregnane X receptors KW - Drugs KW - J 02410:Animal Diseases KW - X 24310:Pharmaceuticals KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19848698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Metabolism+and+Disposition&rft.atitle=The+Pregnane+X+Receptor+Gene-Humanized+Mouse%3A+A+Model+for+Investigating+Drug-Drug+Interactions+Mediated+by+Cytochromes+P450+3A&rft.au=Ma%2C+Xiaochao%3BShah%2C+Yatrik%3BCheung%2C+Connie%3BGuo%2C+Grace+L%3BFeigenbaum%2C+Lionel%3BKrausz%2C+Kristopher+W%3BIdle%2C+Jeffrey+R%3BGonzalez%2C+Frank+J&rft.aulast=Ma&rft.aufirst=Xiaochao&rft.date=2007-02-01&rft.volume=35&rft.issue=2&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Drug+Metabolism+and+Disposition&rft.issn=00909556&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - midazolam; Bacterial artificial chromosomes; Rifampin; Isoenzymes; Animal models; Pregnenolone; Intestine; Liver; pregnane X receptors; Cytochrome P450; Drugs; Pharmacokinetics ER - TY - JOUR T1 - Chemoprevention of rat prostate carcinogenesis by dietary 16 alpha -fluoro-5-androsten-17-one (fluasterone), a minimally androgenic analog of dehydroepiandrosterone AN - 19838359; 7286846 AB - Dehydroepiandrosterone (DHEA) is a potent inhibitor of prostate carcinogenesis in rats. However, concerns related to the possible androgenicity of DHEA may preclude its use for chemoprevention of human prostate cancer. Studies were performed to compare the androgenicity of DHEA and a fluorinated DHEA analog, 16 alpha -fluoro-5-androsten-17-one (fluasterone), and to determine the chemopreventive activity of fluasterone in the rat prostate. Comparisons of accessory sex gland weight and histology in gonadectomized male rats demonstrated that fluasterone is less androgenic than is DHEA. Fluasterone conferred significant protection against prostate carcinogenesis induced in Wistar-Unilever rats by a sequential regimen of N-methyl-N-nitrosourea + testosterone. Chronic administration of fluasterone at levels of 2000 and 1000 mg/kg diet reduced the incidence of adenocarcinoma in the dorsolateral/anterior prostate from 64% in dietary controls to 28 and 31%, respectively. Other than a dose-related suppression of body weight gain, chronic exposure to fluasterone induced no clinical evidence of toxicity; suppression of body weight gain may be either a pharmacological effect or a minimally toxic effect of the compound. These data demonstrate that a minimally androgenic analog of DHEA protects against prostate carcinogenesis induced in rats by a chemical carcinogen + androgen. The reduced androgenicity of fluasterone may obviate toxicities associated with the androgenicity of the parent compound. On this basis, fluasterone merits consideration for evaluation in clinical trials for prostate cancer prevention. The chemopreventive activity of a non-androgenic DHEA analog suggests that at least a portion of the chemopreventive activity of DHEA in the rat prostate is unrelated to hormonal effects. JF - Carcinogenesis AU - McCormick, David L AU - Johnson, William D AU - Kozub, Nicole M AU - Rao, KVN AU - Lubet, Ronald A AU - Steele, Vernon E AU - Bosland, Maarten C AD - Life Sciences Group, IIT Research Institute Chicago, IL 60616, USA. Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute Bethesda, MD 20892, USA. Department of Environmental Medicine and Urology, New York University School of Medicine New York, NY 10016, USA Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 398 EP - 403 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 28 IS - 2 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts KW - Diets KW - Data processing KW - Dehydroepiandrosterone KW - Toxicity KW - N-Methyl-N-nitrosourea KW - Carcinogens KW - Clinical trials KW - Testosterone KW - Prostate cancer KW - Chronic exposure KW - Glands KW - Carcinogenesis KW - Adenocarcinoma KW - Body weight gain KW - Sex KW - Androgens KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19838359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Chemoprevention+of+rat+prostate+carcinogenesis+by+dietary+16+alpha+-fluoro-5-androsten-17-one+%28fluasterone%29%2C+a+minimally+androgenic+analog+of+dehydroepiandrosterone&rft.au=McCormick%2C+David+L%3BJohnson%2C+William+D%3BKozub%2C+Nicole+M%3BRao%2C+KVN%3BLubet%2C+Ronald+A%3BSteele%2C+Vernon+E%3BBosland%2C+Maarten+C&rft.aulast=McCormick&rft.aufirst=David&rft.date=2007-02-01&rft.volume=28&rft.issue=2&rft.spage=398&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diets; Data processing; Dehydroepiandrosterone; Carcinogens; N-Methyl-N-nitrosourea; Toxicity; Clinical trials; Testosterone; Prostate cancer; Chronic exposure; Glands; Carcinogenesis; Body weight gain; Adenocarcinoma; Androgens; Sex ER - TY - JOUR T1 - Automatic 3D tracking of cardiac material markers using slice-following and harmonic-phase MRI AN - 19804369; 8585727 AB - A method to track a grid of cardiac material points in three dimensions using slice-following (SF) tagged magnetic resonance imaging (MRI) and harmonic-phase MRI is presented. A three-dimensional grid of material points on the lines of intersections of short-axis (SA) and long-axis (LA) planes is automatically tracked by combining two-dimensional pathlines that are computed on both SA and la image planes. This process yields the true three-dimensional motion of points originating on the image plane intersections. Experimental data from normal volunteers, each obtained in four short breath-holds using the SF harmonic phase MRI pulse sequence, is presented. A validation of two-dimensional in-plane tracks using this pulse sequence on a moving phantom is also presented. JF - Magnetic Resonance Imaging AU - Sampath, Smita AU - Prince, Jerry L AD - Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USA, sampaths@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 197 EP - 208 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 25 IS - 2 SN - 0730-725X, 0730-725X KW - Biotechnology and Bioengineering Abstracts KW - Magnetic resonance tagging KW - HARP KW - Slice-following KW - Cardiac motion KW - Cardiac strain KW - Heart KW - Data processing KW - Magnetic resonance imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19804369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+Imaging&rft.atitle=Automatic+3D+tracking+of+cardiac+material+markers+using+slice-following+and+harmonic-phase+MRI&rft.au=Sampath%2C+Smita%3BPrince%2C+Jerry+L&rft.aulast=Sampath&rft.aufirst=Smita&rft.date=2007-02-01&rft.volume=25&rft.issue=2&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+Imaging&rft.issn=0730725X&rft_id=info:doi/10.1016%2Fj.mri.2006.09.033 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Data processing; Magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.mri.2006.09.033 ER - TY - JOUR T1 - Efficient protein boosting after plasmid DNA or recombinant adenovirus immunization with HIV-1 vaccine constructs AN - 19741767; 7640435 AB - DNA plasmids and recombinant adenovirus serotype-5 (rAd5) vectors are being studied in human clinical trials as HIV-1 vaccine candidates. Each elicits robust T-cell responses and modest antibody levels. Since protein immunization alone elicits antibody but not CD8 T-cell responses, we studied protein boosting of DNA and rAd5 HIV-1 vaccine vectors. A single Env protein immunization provided a marked boost in antibody titer in guinea pigs primed with either DNA or rAd5 vaccines, and the resulting antibody binding and neutralization levels were similar to those attained after thee sequential protein immunizations. Since both T-cell immunity and neutralizing antibodies are thought to be required for protection against HIV-1, it may be possible to establish a balanced T-cell and antibody response with appropriate vectored vaccines and improve the neutralizing antibody titer with protein boosting. JF - Vaccine AU - Shu, Yuuei AU - Winfrey, Sarah AU - Yang, Zhi-yong AU - Xu, Ling AU - Rao, Srinivas S AU - Srivastava, Indresh AU - Barnett, Susan W AU - Nabel, Gary J AU - Mascola, John R AD - Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, Bethesda, MD 20892, United States, jmascola@nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 1398 EP - 1408 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 25 IS - 8 SN - 0264-410X, 0264-410X KW - Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - HIV KW - Neutralizing antibodies KW - Adjuvant KW - Adenovirus KW - CD8 antigen KW - Immunity KW - Antibody response KW - Plasmids KW - Clinical trials KW - Immunization KW - Expression vectors KW - DNA vaccines KW - Human immunodeficiency virus 1 KW - Envelope protein KW - Lymphocytes T KW - Vaccines KW - V 22360:AIDS and HIV KW - F 06905:Vaccines KW - N 14845:Miscellaneous KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19741767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Efficient+protein+boosting+after+plasmid+DNA+or+recombinant+adenovirus+immunization+with+HIV-1+vaccine+constructs&rft.au=Shu%2C+Yuuei%3BWinfrey%2C+Sarah%3BYang%2C+Zhi-yong%3BXu%2C+Ling%3BRao%2C+Srinivas+S%3BSrivastava%2C+Indresh%3BBarnett%2C+Susan+W%3BNabel%2C+Gary+J%3BMascola%2C+John+R&rft.aulast=Shu&rft.aufirst=Yuuei&rft.date=2007-02-01&rft.volume=25&rft.issue=8&rft.spage=1398&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2006.10.046 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Expression vectors; DNA vaccines; Envelope protein; Lymphocytes T; Antibody response; Immunity; CD8 antigen; Vaccines; Plasmids; Clinical trials; Immunization; Human immunodeficiency virus 1; Adenovirus DO - http://dx.doi.org/10.1016/j.vaccine.2006.10.046 ER - TY - JOUR T1 - Long-Lasting Decrease in Viremia in Macaques Chronically Infected with Simian Immunodeficiency Virus SIVmac251 after Therapeutic DNA Immunization AN - 19735648; 7254034 AB - Rhesus macaques chronically infected with highly pathogenic simian immunodeficiency virus (SIV) SIVmac251 were treated with antiretroviral drugs and vaccinated with combinations of DNA vectors expressing SIV antigens. Vaccination during therapy increased cellular immune responses. After the animals were released from therapy, the virus levels of 12 immunized animals were significantly lower (P = 0.001) compared to those of 11 animals treated with only antiretroviral drugs. Vaccinated animals showed a persistent increase in immune responses, thus indicating both a virological and an immunological benefit following DNA therapeutic vaccination. Several animals show a long-lasting decrease in viremia, suggesting that therapeutic vaccination may provide an additional benefit to antiretroviral therapy. JF - Journal of Virology AU - von Gegerfelt, Agneta S AU - Rosati, Margherita AU - Alicea, Candido AU - Valentin, Antonio AU - Roth, Patricia AU - Bear, Jenifer AU - Franchini, Genoveffa AU - Albert, Paul S AU - Bischofberger, Norbert AU - Boyer, Jean D AU - Weiner, David B AU - Markham, Phillip AU - Israel, Zimra R AU - Eldridge, John H AU - Pavlakis, George N AU - Felber, Barbara K AD - Human Retrovirus Section. Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702. Animal Models and Retroviral Vaccines Section, Vaccine Branch, Center for Cancer Research. Biometric Research Branch, National Cancer Institute, Bethesda, Maryland 20892. Gilead Sciences, Foster City, California 94404. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104. Advanced BioSciences Laboratories, Inc., Kensington, Maryland 20895. Wyeth Vaccines Research, Pearl River, New York 10965 Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 1972 EP - 1979 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 81 IS - 4 SN - 0022-538X, 0022-538X KW - Rhesus macaque KW - Rhesus monkey KW - Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - DNA vaccines KW - Antiviral agents KW - antiretroviral therapy KW - DNA KW - Macaca mulatta KW - Viremia KW - Vaccination KW - Immunosuppressive agents KW - Simian immunodeficiency virus KW - V 22360:AIDS and HIV KW - F 06905:Vaccines KW - N 14845:Miscellaneous KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19735648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Long-Lasting+Decrease+in+Viremia+in+Macaques+Chronically+Infected+with+Simian+Immunodeficiency+Virus+SIVmac251+after+Therapeutic+DNA+Immunization&rft.au=von+Gegerfelt%2C+Agneta+S%3BRosati%2C+Margherita%3BAlicea%2C+Candido%3BValentin%2C+Antonio%3BRoth%2C+Patricia%3BBear%2C+Jenifer%3BFranchini%2C+Genoveffa%3BAlbert%2C+Paul+S%3BBischofberger%2C+Norbert%3BBoyer%2C+Jean+D%3BWeiner%2C+David+B%3BMarkham%2C+Phillip%3BIsrael%2C+Zimra+R%3BEldridge%2C+John+H%3BPavlakis%2C+George+N%3BFelber%2C+Barbara+K&rft.aulast=von+Gegerfelt&rft.aufirst=Agneta&rft.date=2007-02-01&rft.volume=81&rft.issue=4&rft.spage=1972&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Antiviral agents; DNA vaccines; antiretroviral therapy; DNA; Viremia; Immunosuppressive agents; Vaccination; Macaca mulatta; Simian immunodeficiency virus ER - TY - JOUR T1 - NCI Thesaurus: A semantic model integrating cancer-related clinical and molecular information AN - 19728567; 7504508 AB - Over the last 8 years, the National Cancer Institute (NCI) has launched a major effort to integrate molecular and clinical cancer-related information within a unified biomedical informatics framework, with controlled terminology as its foundational layer. The NCI Thesaurus is the reference terminology underpinning these efforts. It is designed to meet the growing need for accurate, comprehensive, and shared terminology, covering topics including: cancers, findings, drugs, therapies, anatomy, genes, pathways, cellular and subcellular processes, proteins, and experimental organisms. The NCI Thesaurus provides a partial model of how these things relate to each other, responding to actual user needs and implemented in a deductive logic framework that can help maintain the integrity and extend the informational power of what is provided. This paper presents the semantic model for cancer diseases and its uses in integrating clinical and molecular knowledge, more briefly examines the models and uses for drug, biochemical pathway, and mouse terminology, and discusses limits of the current approach and directions for future work. JF - Journal of Biomedical Informatics AU - Sioutos, Nicholas AU - de Coronado, Sherri AU - Haber, Margaret W AU - Hartel, Frank W AU - Shaiu, Wen-Ling AU - Wright, Lawrence W AD - Aspen Systems Corporation, USA, decorons@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 30 EP - 43 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 40 IS - 1 SN - 1532-0464, 1532-0464 KW - Biotechnology and Bioengineering Abstracts KW - Biomedical vocabulary KW - Ontology development KW - Cancer research KW - Disease model KW - Cancer terminology KW - Molecular modelling KW - Animal models KW - Bioinformatics KW - Drugs KW - Cancer KW - Semantics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19728567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Informatics&rft.atitle=NCI+Thesaurus%3A+A+semantic+model+integrating+cancer-related+clinical+and+molecular+information&rft.au=Sioutos%2C+Nicholas%3Bde+Coronado%2C+Sherri%3BHaber%2C+Margaret+W%3BHartel%2C+Frank+W%3BShaiu%2C+Wen-Ling%3BWright%2C+Lawrence+W&rft.aulast=Sioutos&rft.aufirst=Nicholas&rft.date=2007-02-01&rft.volume=40&rft.issue=1&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Informatics&rft.issn=15320464&rft_id=info:doi/10.1016%2Fj.jbi.2006.02.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Animal models; Bioinformatics; Drugs; Cancer; Semantics DO - http://dx.doi.org/10.1016/j.jbi.2006.02.013 ER - TY - JOUR T1 - Dectin-1 promotes fungicidal activity of human neutrophils AN - 19727274; 7515713 AB - Human polymorphonuclear leukocytes (PMN) are a first line of defense against fungal infections. PMN express numerous pattern recognition receptors (PRR) that facilitate identification of invading microorganisms and ultimately promote resolution of disease. Dectin-1 (-glucan receptor) is a PRR expressed on several cell types and has been studied on monocytes and macrophages. However, the role played by dectin-1 in the recognition and killing of fungi by PMN is unknown. We investigated the ability of dectin-1 to mediate human PMN phagocytosis and fungicidal activity. Dectin-1 was expressed on the surface of PMN from all subjects tested (n=29) and in an intracellular compartment that co-sedimented with azurophilic granules in Percoll density gradients. Soluble -glucan and mAb GE2 (anti-dectin-1) inhibited binding and phagocytosis of zymosan by human PMN (e.g., ingestion was inhibited 40.1% by 30min, p<0.001), and blocked reactive oxygen species production. Notably, soluble -glucan and GE2 inhibited phagocytosis and killing of Candida albicans by PMN (inhibition of killing was 54.8% for -glucan and 36.2% for GE2, p<0.01). Our results reveal a mechanism whereby PMN dectin-1 plays a key role in the recognition and killing of fungal pathogens by the innate immune system. JF - European Journal of Immunology AU - Kennedy, Adam D AU - Willment, Janet A AU - Dorward, David W AU - Williams, David L AU - Brown, Gordon D AU - Deleo, Frank R AD - Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA, fdeleo@niaid.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 467 EP - 478 PB - Wiley-VCH, Postfach 101161 Weinheim 69451 Germany, [mailto:info@wiley-vch.de], [URL:http://www.wiley-vch.de/publish/en/] VL - 37 IS - 2 SN - 0014-2980, 0014-2980 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - Macrophages KW - Granules KW - Monoclonal antibodies KW - Immune system KW - Leukocytes (polymorphonuclear) KW - Fungi KW - Fungicidal activity KW - Leukocytes (neutrophilic) KW - Candida albicans KW - Pathogens KW - Infection KW - Pattern recognition KW - Density gradients KW - Reactive oxygen species KW - Microorganisms KW - Monocytes KW - Phagocytosis KW - A 01380:Plant Protection, Fungicides & Seed Treatments KW - K 03350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19727274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Immunology&rft.atitle=Dectin-1+promotes+fungicidal+activity+of+human+neutrophils&rft.au=Kennedy%2C+Adam+D%3BWillment%2C+Janet+A%3BDorward%2C+David+W%3BWilliams%2C+David+L%3BBrown%2C+Gordon+D%3BDeleo%2C+Frank+R&rft.aulast=Kennedy&rft.aufirst=Adam&rft.date=2007-02-01&rft.volume=37&rft.issue=2&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Immunology&rft.issn=00142980&rft_id=info:doi/10.1002%2Feji.200636653 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Granules; Macrophages; Monoclonal antibodies; Fungi; Leukocytes (polymorphonuclear); Immune system; Fungicidal activity; Leukocytes (neutrophilic); Pathogens; Infection; Pattern recognition; Reactive oxygen species; Density gradients; Microorganisms; Monocytes; Phagocytosis; Candida albicans DO - http://dx.doi.org/10.1002/eji.200636653 ER - TY - JOUR T1 - Assessment by Cardiovascular Magnetic Resonance, Electron Beam Computed Tomography, and Carotid Ultrasonography of the Distribution of Subclinical Atherosclerosis Across Framingham Risk Strata AN - 19722599; 7512097 AB - Screening for subclinical atherosclerosis has been advocated for individuals at intermediate global risk for coronary heart disease (CHD). However, the distribution of subclinical atherosclerosis test values across CHD risk strata is unknown. We studied a stratified random sample of 292 participants (mean age 59.5 years, 50% women) from the offspring cohort of the Framingham Heart Study who were free of clinically apparent cardiovascular disease. We assessed abdominal and thoracic aortic plaque burden by cardiovascular magnetic resonance (CMR), coronary artery calcification (CAC) and thoracic aortic calcification (TAC) by electron beam computed tomography, and common carotid intima-media thickness (C-IMT) by ultrasonography. We categorized the upper 20% of each measurement as a high level of atherosclerosis and evaluated these variables across clinically relevant Framingham CHD risk score strata (low, intermediate, and high risk). In age-adjusted analyses in men and women, correlations across CMR aortic plaque, CAC, TAC, and C-IMT were low (maximum r = 0.30 for CAC:TAC in women, p =2 measurements. However, different participants were identified as having high atherosclerosis by each modality. For example, in a comparison of the overlap across CMR aortic plaque, CAC, and C-IMT, only 4% of men and 16% of women were classified as having high atherosclerosis on all 3 measurements. In conclusion, in a community-based sample, correlations among subclinical atherosclerosis test results are low, and a substantial proportion has high levels of subclinical atherosclerosis detected on >=2 imaging tests. JF - American Journal of Cardiology AU - Kathiresan, Sekar AU - Scd, Martin G Larson AU - Keyes, Michelle J AU - Polak, Joseph F AU - Wolf, Philip A AU - D'Agostino, Ralph B AU - Jaffer, Farouc A AU - Clouse, Melvin E AU - Levy, Daniel AU - Manning, Warren J AU - O'Donnell, Christopher J AD - Framingham Heart Study, Framingham, Massachusetts, codonell@nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 310 EP - 314 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 99 IS - 3 SN - 0002-9149, 0002-9149 KW - Biotechnology and Bioengineering Abstracts KW - Risk assessment KW - Age KW - Aorta KW - Calcification (ectopic) KW - Arteriosclerosis KW - imaging KW - Ultrasonography KW - Coronary heart disease KW - coronary artery KW - Risk factors KW - Computed tomography KW - Thorax KW - Progeny KW - N.M.R. KW - Plaques KW - Cardiovascular diseases KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19722599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Cardiology&rft.atitle=Assessment+by+Cardiovascular+Magnetic+Resonance%2C+Electron+Beam+Computed+Tomography%2C+and+Carotid+Ultrasonography+of+the+Distribution+of+Subclinical+Atherosclerosis+Across+Framingham+Risk+Strata&rft.au=Kathiresan%2C+Sekar%3BScd%2C+Martin+G+Larson%3BKeyes%2C+Michelle+J%3BPolak%2C+Joseph+F%3BWolf%2C+Philip+A%3BD%27Agostino%2C+Ralph+B%3BJaffer%2C+Farouc+A%3BClouse%2C+Melvin+E%3BLevy%2C+Daniel%3BManning%2C+Warren+J%3BO%27Donnell%2C+Christopher+J&rft.aulast=Kathiresan&rft.aufirst=Sekar&rft.date=2007-02-01&rft.volume=99&rft.issue=3&rft.spage=310&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Cardiology&rft.issn=00029149&rft_id=info:doi/10.1016%2Fj.amjcard.2006.08.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Arteriosclerosis; Aorta; Plaques; Ultrasonography; Calcification (ectopic); N.M.R.; Computed tomography; Risk factors; Thorax; imaging; Progeny; Risk assessment; Coronary heart disease; Cardiovascular diseases; coronary artery; Age DO - http://dx.doi.org/10.1016/j.amjcard.2006.08.028 ER - TY - JOUR T1 - Increased anxiety and other similarities in temperament of alcoholics with and without antisocial personality disorder across three diverse populations AN - 19721028; 7511442 AB - According to Cloninger's model, type I alcoholics are thought to be innately vulnerable to anxiety and depression. In contrast, type II alcoholics are thought to have increased likelihood of antisocial personality disorder (ASPD) and reduced anxiety. However, allostatic activations of stress, anxiety, and dysphoria may be a common thread in alcohol use disorders (AUDs). Our aim was to find commonalities and differences in temperament of alcoholics with and without ASPD in three diverse populations. By sib-sib comparisons, we also evaluated the extent to which the temperament traits were moderated by familial factors including inheritance. We compared harm avoidance (HA), novelty seeking (NS), and reward dependence (RD) in alcoholics with ASPD, alcoholics without ASPD, and controls. Correlations for each temperament dimension were evaluated in pairs of siblings concordant and discordant for AUD. Participants were derived from three independent populations: Finnish Caucasians (N=453, men=100%, including a sample of alcoholic criminals), a Plains American Indian community sample (N=378; men=42%), and a subset of the familial and predominantly Caucasian Collaborative Study on the Genetics of Alcoholism (COGA) sample (N=967, men=47%). In all the three populations, both alcoholics with and without ASPD were higher in HA than controls. The increase of HA among alcoholics as compared to controls ranged from 54% to 12%. In two populations (COGA and Finns), NS was highest in alcoholics with ASPD, intermediate in alcoholics without ASPD, and lowest in controls. HA levels were correlated in sib-pairs concordant (either affected or unaffected) for AUD but not in discordant pairs. In conclusions, despite cultural diversity and different modes of ascertainment we found a consistent pattern of elevated HA in all groups of alcoholics, including alcoholics with ASPD. Even in alcoholics with long-term exposure to the anxiogenic effects of repeated cycles of alcohol withdrawal, genetic and other familial influences seem to play a role in moderating anxiety. JF - Alcohol AU - Ducci, Francesca AU - Enoch, Mary-Anne AU - Funt, Samuel AU - Virkkunen, Matti AU - Albaugh, Bernard AU - Goldman, David AD - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, 5625 Fishers Lane, Room 3S32, MSC 9412, Bethesda MD 20892, USA, duccif@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 3 EP - 12 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 41 IS - 1 SN - 0741-8329, 0741-8329 KW - Toxicology Abstracts KW - Harm avoidance KW - Novelty seeking KW - Alcohol use disorders KW - ASPD KW - Anxiety KW - Heredity KW - Personality KW - Stress KW - Drug abuse KW - Alcoholics KW - Models KW - Alcoholism KW - Social behavior KW - Reinforcement KW - Siblings KW - Ethanol KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19721028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol&rft.atitle=Increased+anxiety+and+other+similarities+in+temperament+of+alcoholics+with+and+without+antisocial+personality+disorder+across+three+diverse+populations&rft.au=Ducci%2C+Francesca%3BEnoch%2C+Mary-Anne%3BFunt%2C+Samuel%3BVirkkunen%2C+Matti%3BAlbaugh%2C+Bernard%3BGoldman%2C+David&rft.aulast=Ducci&rft.aufirst=Francesca&rft.date=2007-02-01&rft.volume=41&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Alcohol&rft.issn=07418329&rft_id=info:doi/10.1016%2Fj.alcohol.2007.02.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Heredity; Anxiety; Alcoholism; Reinforcement; Social behavior; Personality; Stress; Siblings; Drug abuse; Alcoholics; Models; Ethanol DO - http://dx.doi.org/10.1016/j.alcohol.2007.02.005 ER - TY - JOUR T1 - Persistent bacterial infections and primary immune disorders AN - 19668779; 7424458 AB - Mycobacteria, Salmonella and Helicobacter species have all evolved mechanisms to evade host defenses and cause persistent infection in humans. Host control of mycobacteria and Salmonella is largely achieved by the IFN-/IL-12 pathway. Immune disorders affecting this pathway are characterized by disseminated infections with environmental or nontuberculous mycobacteria. Helicobacter is a predominantly extracellular bacterium that uses its remarkable genetic diversity (as well as other mechanisms) in order to evade host defenses. The importance of humoral immunity in containing Helicobacter infections to the mucosal surface is illustrated by the primary immune disorder, X-linked agammaglobulinemia in which patients are prone to chronic bacteremia and skin infections by Helicobacter and related species such as Flexispira and Campylobacter. Exploration of these particular infections in their specific immune defects sheds light on both host and bacterial mechanisms that have implications for pathogenesis and therapy. JF - Current Opinion in Microbiology AU - Freeman, Alexandra F AU - Holland, Steven M AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1684, USA, smh@nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 70 EP - 75 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 10 IS - 1 SN - 1369-5274, 1369-5274 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Bacteria KW - Skin KW - Helicobacter KW - Mucosa KW - Disseminated infection KW - Campylobacter KW - Bacteremia KW - Genetic diversity KW - Persistent infection KW - Immunity (humoral) KW - Interleukin 12 KW - Interferon KW - Reviews KW - X-linked agammaglobulinemia KW - Chronic infection KW - Salmonella KW - A 01340:Antibiotics & Antimicrobials KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19668779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Microbiology&rft.atitle=Persistent+bacterial+infections+and+primary+immune+disorders&rft.au=Freeman%2C+Alexandra+F%3BHolland%2C+Steven+M&rft.aulast=Freeman&rft.aufirst=Alexandra&rft.date=2007-02-01&rft.volume=10&rft.issue=1&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Microbiology&rft.issn=13695274&rft_id=info:doi/10.1016%2Fj.mib.2006.11.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Immunity (humoral); Interferon; Interleukin 12; Skin; X-linked agammaglobulinemia; Reviews; Disseminated infection; Mucosa; Chronic infection; Genetic diversity; Bacteremia; Persistent infection; Bacteria; Helicobacter; Campylobacter; Salmonella DO - http://dx.doi.org/10.1016/j.mib.2006.11.005 ER - TY - JOUR T1 - Plasma concentrations of free triiodothyronine predict weight change in euthyroid persons AN - 19666857; 7427649 AB - Background: Factors that influence energy metabolism and substrate oxidation, such as thyroid hormones (THs), may be important regulators of body weight. Objective: We investigated associations of THs cross-sectionally with obesity, energy expenditure, and substrate oxidation and prospectively with weight change. Design: Euthyroid, nondiabetic, healthy, adult Pima Indians (n = 89; 47 M, 42 F) were studied. Percentage body fat (%BF) was measured by using dual-energy X-ray absorptiometry; sleeping metabolic rate (SMR), respiratory quotient, and substrate oxidation rates were measured in a respiratory chamber. Thyroid-stimulating hormone (TSH), free thyroxine (T sub(4)), free triiodothyronine (T sub(3)), and leptin concentrations were measured in fasting plasma samples. Results: TSH, but neither free T sub(3) nor free T sub(4), was associated with %BF and leptin concentrations (r = 0.27 and 0.29, respectively; both: P less than or equal to 0.01). In multiple regression analyses adjusted for age, sex, fat mass, and fat-free mass, free T sub(3) was a positive predictor of SMR (P = 0.02). After adjustment for age, sex, %BF, and energy balance, free T sub(3) was a negative predictor of 24-h respiratory quotient (P < 0.05) and a positive predictor of 24-h lipid oxidation rate (P = 0.006). Prospectively, after an average follow-up of 4 plus or minus 2 y, the mean increase in weight was 3 plus or minus 9 kg. Baseline T sub(3) concentrations were associated with absolute and annual percentage of changes in weight (r = -0.27, P = 0.02, and r = -0.28, P = 0.009, for the age- and sex-adjusted associations, respectively). Conclusions: In euthyroid Pima Indians, lower free T sub(3) but not free T sub(4) concentrations were an independent predictor of SMR and lipid oxidation and a predictor of weight gain. This finding indicates that control of T sub(4)-to-T sub(3) conversion may play a role in body weight regulation. JF - American Journal of Clinical Nutrition AU - Ortega, E AU - Pannacciulli, N AU - Bogardus, C AU - Krakoff, J AD - Obesity and Diabetes Clinical Research Section, Phoenix Epidemiological Clinical and Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, AZ, USA Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 440 EP - 445 VL - 85 IS - 2 SN - 0002-9165, 0002-9165 KW - Physical Education Index KW - Obesity KW - Measurement KW - Lipids KW - Health KW - Adults KW - Nutrition KW - Hormones KW - X-Ray KW - Energy cost KW - Weight KW - Analysis KW - Metabolism KW - Ethnic groups KW - Sex KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19666857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Clinical+Nutrition&rft.atitle=Plasma+concentrations+of+free+triiodothyronine+predict+weight+change+in+euthyroid+persons&rft.au=Ortega%2C+E%3BPannacciulli%2C+N%3BBogardus%2C+C%3BKrakoff%2C+J&rft.aulast=Ortega&rft.aufirst=E&rft.date=2007-02-01&rft.volume=85&rft.issue=2&rft.spage=440&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Clinical+Nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Measurement; Obesity; Lipids; Health; Adults; Hormones; Nutrition; Energy cost; X-Ray; Weight; Analysis; Ethnic groups; Metabolism; Sex ER - TY - JOUR T1 - Determination and Analysis of Site-Specific super(125)I Decay-Induced DNA Double-Strand Break End-Group Structures AN - 19654715; 7410711 AB - End groups contribute to the structural complexity of radiation-induced DNA double-strand breaks (DSBs). As such, end-group structures may affect a cell's ability to repair DSBs. The 3'-end groups of strand breaks caused by gamma radiation, or oxidative processes, under oxygenated aqueous conditions have been shown to be distributed primarily between 3'-phosphoglycolate and 3'-phosphate, with 5'-phosphate ends in both cases. In this study, end groups of the high-LET-like DSBs caused by super(125)I decay were investigated. Site-specific DNA double-strand breaks were produced in plasmid pTC27 in the presence or absence of 2 M DMSO by super(125)I-labeled triplex-forming oligonucleotide targeting. End-group structure was assessed enzymatically as a function of the DSB end to serve as a substrate for ligation and various forms of end labeling. Using this approach, we have demonstrated 3'-hydroxyl (3'-OH) and 3'-phosphate (3'-P) end groups and 5'-ends ( greater than or equal to 42%) terminated by phosphate. A super(32)P postlabeling assay failed to detect 3'-phosphoglycolate in a restriction fragment terminated by the super(125)I-induced DNA double-strand break, and this is likely due to restricted oxygen diffusion during irradiation as a frozen aqueous solution. Even so, end-group structure and relative distribution varied as a function of the free radical scavenging capacity of the irradiation buffer. JF - Radiation Research AU - Datta, K AU - Weinfeld, M AU - Neumann, R D AU - Winters, T A AD - Nuclear Medicine Department Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 152 EP - 166 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com], [URL:http://www.allenpress.com] VL - 167 IS - 2 SN - 0033-7587, 0033-7587 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - DNA damage KW - Oxygen KW - Phosphate KW - Free radicals KW - gamma Radiation KW - Diffusion KW - Plasmids KW - Oligonucleotides KW - X 24390:Radioactive Materials KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19654715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Determination+and+Analysis+of+Site-Specific+super%28125%29I+Decay-Induced+DNA+Double-Strand+Break+End-Group+Structures&rft.au=Datta%2C+K%3BWeinfeld%2C+M%3BNeumann%2C+R+D%3BWinters%2C+T+A&rft.aulast=Datta&rft.aufirst=K&rft.date=2007-02-01&rft.volume=167&rft.issue=2&rft.spage=152&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR0629.1 L2 - http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0033-7587&volume=167&issue=2&page=152 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Oxygen; DNA damage; Phosphate; Free radicals; gamma Radiation; Diffusion; Plasmids; Oligonucleotides DO - http://dx.doi.org/10.1667/RR0629.1 ER - TY - JOUR T1 - A Cell-Based Assay for I Kappa B alpha Stabilization Using a Two-Color Dual Luciferase-Based Sensor AN - 19625794; 7361114 AB - A cell-sensor assay for stabilization of I Kappa B alpha was developed in the activated B cell-like diffuse large B-cell lymphoma cell line OCI-Ly3. This cell line expresses known nuclear factor Kappa B (NF Kappa B) target genes due to high constitutive activity of I Kappa B kinase (IKK), which phosphorylates the protein I Kappa B alpha leading to proteasomal degradation of I Kappa B alpha and activation of NF Kappa B. The cell-sensor assay uses green and red light-emitting beetle luciferases, with the green luciferase fused to I Kappa B alpha (I Kappa B alpha -CBG68) and the red luciferase (CBR) present in its native state. The I Kappa B alpha -CBG68 reporter functions as a sensor of IKK and proteasome activity, while CBR serves to normalize for cell number and nonspecific effects. Both reporter constructs were stably integrated and placed under the control of an inducible promoter system, which increased fold responsiveness to inhibitors when assay incubations were performed simultaneous to reporter induction by doxycycline. The assay was miniaturized to a 1,536-well plate format and showed a Z' of 0.6; it was then used to panel 2,677 bioactive compounds by a concentration-response-based screening strategy. The concentration-effect curves for the I Kappa B alpha -CBG68 and CBR signals were then used to identify specific stabilizers of I Kappa B alpha , such as IKK inhibitors or proteasome inhibitors, which increased the doxycycline-induced rise in I Kappa B alpha -CBG68 without affecting the rise in CBR. Known and unexpected inhibitors of NF Kappa B signaling were identified from the bioactive collection. We describe here the development and performance of this assay, and discuss the merits of its specific features. JF - Assay and Drug Development Technologies AU - Davis, R E AU - Zhang, Y-Q AU - Southall, N AU - Staudt, L M AU - Austin, C P AU - Inglese, J AU - Auld, D S AD - NIH Chemical Genomics Center National Human Genome Research Institute National Institutes of Health 9800 Medical Center Drive Bethesda, MD 20892-3370, USA, dauld@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 85 EP - 103 VL - 5 IS - 1 SN - 1540-658X, 1540-658X KW - Biotechnology and Bioengineering Abstracts KW - double prime B-cell lymphoma KW - Cell number KW - Lymphocytes B KW - proteasomes KW - Drug development KW - IKK protein KW - Promoters KW - I Kappa B kinase KW - Tumor cell lines KW - Doxycycline KW - proteasome inhibitors KW - Signal transduction KW - W 30955:Biosensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19625794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Assay+and+Drug+Development+Technologies&rft.atitle=A+Cell-Based+Assay+for+I+Kappa+B+alpha+Stabilization+Using+a+Two-Color+Dual+Luciferase-Based+Sensor&rft.au=Davis%2C+R+E%3BZhang%2C+Y-Q%3BSouthall%2C+N%3BStaudt%2C+L+M%3BAustin%2C+C+P%3BInglese%2C+J%3BAuld%2C+D+S&rft.aulast=Davis&rft.aufirst=R&rft.date=2007-02-01&rft.volume=5&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Assay+and+Drug+Development+Technologies&rft.issn=1540658X&rft_id=info:doi/10.1089%2Fadt.2006.048 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - I Kappa B kinase; Promoters; Tumor cell lines; double prime B-cell lymphoma; Cell number; Lymphocytes B; proteasomes; Drug development; IKK protein; proteasome inhibitors; Doxycycline; Signal transduction DO - http://dx.doi.org/10.1089/adt.2006.048 ER - TY - JOUR T1 - Neural correlates of response reversal: Considering acquisition AN - 19618254; 7345973 AB - Previous work on response reversal has typically used a single pair of stimuli that serially reverse. This conflation of acquisition and reversal processes has prevented an examination of the functional role of neural systems implicated in response reversal during acquisition despite the relevance of such data in evaluating accounts of response reversal. In the current study, participants encountered 16 independent reversing stimulus pairs in the context of a probabilistic response reversal paradigm. Functional regions of interest identified as involved in response reversal through a contrast used in the previous literature (punished errors made in the reversal phase versus rewarded correct responses), were interrogated across conditions. Consistent with suggestions that middle frontal cortex codes reward, this region showed significantly greater responses to rewarded rather than punished trials irrespective of accuracy or learning phase (acquisition or reversal). Consistent with the suggestion that this coding of the expectation of reinforcement is acquired via input from the amygdala, we observed significant positive connectivity between activity within the amygdala and a region of rostral anterior cingulate cortex highly proximal to this region of middle frontal/mesial prefrontal cortex. In contrast, inferior frontal cortex, anterior cingulate cortex and caudate showed greater responses to punished errors than to the rewarded correct responses. These three regions also showed significant activation to rewarded errors during acquisition, in contrast to positions suggesting that inferior frontal cortex represents punishment or suppresses previously rewarded responses. Moreover, a connectivity analysis with an anterior cingulate cortex seed revealed highly significant positive connectivity among them. The implications of these data for recent accounts of response reversal and of response reversal impairments in specific neuropsychiatric populations are discussed. JF - NeuroImage AU - Budhani, S AU - Marsh, A A AU - Pine, D S AU - Blair, RJR AD - Department of Psychology, University College London, London WC1E 6BT, UK, James.Blair@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 1754 EP - 1765 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 34 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Caudate KW - Anterior cingulate KW - Probabilistic reversal learning KW - Psychopathy KW - Inferior frontal cortex KW - Coding KW - Learning KW - Seeds KW - Neural networks KW - Punishment KW - Reinforcement KW - Cortex (frontal) KW - Amygdala KW - Cortex (prefrontal) KW - Cortex (cingulate) KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19618254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Neural+correlates+of+response+reversal%3A+Considering+acquisition&rft.au=Budhani%2C+S%3BMarsh%2C+A+A%3BPine%2C+D+S%3BBlair%2C+RJR&rft.aulast=Budhani&rft.aufirst=S&rft.date=2007-02-01&rft.volume=34&rft.issue=4&rft.spage=1754&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2006.08.060 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Coding; Seeds; Learning; Neural networks; Punishment; Reinforcement; Cortex (frontal); Amygdala; Cortex (cingulate); Cortex (prefrontal) DO - http://dx.doi.org/10.1016/j.neuroimage.2006.08.060 ER - TY - JOUR T1 - Imaging signal transduction via arachidonic acid in the human brain during visual stimulation, by means of positron emission tomography AN - 19615562; 7345934 AB - 6 months [OR = 1.95; 95% confidence interval (95% CI) = 1.09-3.51]. Excluding pregnancies after 13+ months resulted in a loss of precision (OR = 2.14; 95% CI = 0.90-5.04). CONCLUSIONS: These data support higher fecundity among mothers of multiples than mothers of singletons. JF - Human Reproduction AU - Ferrari, R M AU - Cooney, MA AU - Vexler, A AU - Liu, A AU - Buck Louis, GM AD - Department of Maternal and Child Health, University of North Carolina at Chapel Hill, Chapel Hill, NC. Epidemiology Branch and. Biometry Branch, National Institute of Child Health and Human Development, Rockville, MD, USA Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 407 EP - 413 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 22 IS - 2 SN - 0268-1161, 0268-1161 KW - Sustainability Science Abstracts KW - fecundity KW - Reproduction KW - Pregnancy KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19538371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Reproduction&rft.atitle=Time+to+pregnancy+and+multiple+births&rft.au=Ferrari%2C+R+M%3BCooney%2C+MA%3BVexler%2C+A%3BLiu%2C+A%3BBuck+Louis%2C+GM&rft.aulast=Ferrari&rft.aufirst=R&rft.date=2007-02-01&rft.volume=22&rft.issue=2&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=Human+Reproduction&rft.issn=02681161&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - fecundity; Reproduction; Pregnancy ER - TY - JOUR T1 - Prevention of Immune Cell Apoptosis as Potential Therapeutic Strategy for Severe Infections AN - 19526944; 7828851 AB - Some labile cell types whose numbers are normally controiled through programmed cell death are subject to markedly increased destruction during some severe infections. Lymphocytes, in particular, undergo massive and apparently unregulated apoptosis in human patients and laboratory animals with sepsis, potentially playing a major role in the severe immunosuppression that characterizes the terminal phase of fatal illness. Extensive lymphocyte apoptosis has also occurred in humans and animals infected with several exotic agents, including Bacillus anthracis, the cause of anthrax; Yersinia pestis, the cause of plague; and Ebola virus. Prevention of lymphocyte apoptosis, through either genetic modification of the host or treatment with specific inhibitors, markedly improves survival in murine sepsis models. These findings suggest that interventions aimed at reducing the extent of immune cell apoptosis could improve outcomes for a variety of severe human infections, including those caused by emerging pathogens and bioterrorism agents. JF - Emerging Infectious Diseases AU - Parrlno, J AU - Hotchklss, R S AU - Bray, M AD - National Institutes of Health, Bethesda, Maryland, USA Y1 - 2007/02// PY - 2007 DA - Feb 2007 VL - 13 IS - 2 SN - 1080-6040, 1080-6040 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Cell survival KW - Apoptosis KW - bioterrorism KW - Animal models KW - Laboratory animals KW - Yersinia pestis KW - Ebola virus KW - Lymphocytes KW - Pathogens KW - Bacillus anthracis KW - Infection KW - Sepsis KW - Anthrax KW - Plague KW - Immunosuppression KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19526944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Emerging+Infectious+Diseases&rft.atitle=Prevention+of+Immune+Cell+Apoptosis+as+Potential+Therapeutic+Strategy+for+Severe+Infections&rft.au=Parrlno%2C+J%3BHotchklss%2C+R+S%3BBray%2C+M&rft.aulast=Parrlno&rft.aufirst=J&rft.date=2007-02-01&rft.volume=13&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Emerging+Infectious+Diseases&rft.issn=10806040&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell survival; Sepsis; Apoptosis; bioterrorism; Laboratory animals; Animal models; Anthrax; Plague; Pathogens; Lymphocytes; Infection; Immunosuppression; Yersinia pestis; Ebola virus; Bacillus anthracis ER - TY - JOUR T1 - Data mining of NCIs anticancer screening database reveals mitochondrial complex I inhibitors cytotoxic to leukemia cell lines AN - 19491756; 7185601 AB - Mitochondria are principal mediators of apoptosis and thus can be considered molecular targets for new chemotherapeutic agents in the treatment of cancer. Inhibitors of mitochondrial complex I of the electron transport chain have been shown to induce apoptosis and exhibit antitumor activity. In an effort to find novel complex I inhibitors which exhibited anticancer activity in the NCIs tumor cell line screen, we examined organized tumor cytotoxicity screening data available as SOM (self-organized maps) (http://www.spheroid.ncifcrf.gov) at the developmental therapeutics program (DTP) of the National Cancer Institute (NCI). Our analysis focused on an SOM cluster comprised of compounds which included a number of known mitochondrial complex I (NADH:CoQ oxidoreductase) inhibitors. From these clusters 10 compounds whose mechanism of action was unknown were tested for inhibition of complex I activity in bovine heart sub-mitochondrial particles (SMP) resulting in the discovery that 5 of the 10 compounds demonstrated significant inhibition with IC sub(50)s in the nM range for three of the five. Examination of screening profiles of the five inhibitors toward the NCIs tumor cell lines revealed that they were cytotoxic to the leukemia subpanel (particularly K562 cells). Oxygen consumption experiments with permeabilized K562 cells revealed that the five most active compounds inhibited complex I activity in these cells in the same rank order and similar potency as determined with bovine heart SMP. Our findings thus fortify the appeal of mitochondrial complex I as a possible anticancer molecular target and provide a data mining strategy for selecting candidate inhibitors for further testing. JF - Biochemical Pharmacology AU - Glover, Constance J AU - Rabow, Alfred A AU - Isgor, Yasemin G AU - Shoemaker, Robert H AU - Covell, David G AD - Developmental Therapeutics Program, National Cancer Institute at Frederick, Frederick, MD 21702, United States, cglover@mail.ncifcrf.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 331 EP - 340 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 73 IS - 3 SN - 0006-2952, 0006-2952 KW - Biotechnology and Bioengineering Abstracts KW - Oxygen consumption KW - Heart KW - Apoptosis KW - Data processing KW - Chemotherapy KW - Mitochondria KW - Tumors KW - Cancer KW - Databases KW - Cytotoxicity KW - Tumor cell lines KW - oxidoreductase KW - NADH-ubiquinone oxidoreductase KW - Electron transport chain KW - Antitumor activity KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19491756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+Pharmacology&rft.atitle=Data+mining+of+NCIs+anticancer+screening+database+reveals+mitochondrial+complex+I+inhibitors+cytotoxic+to+leukemia+cell+lines&rft.au=Glover%2C+Constance+J%3BRabow%2C+Alfred+A%3BIsgor%2C+Yasemin+G%3BShoemaker%2C+Robert+H%3BCovell%2C+David+G&rft.aulast=Glover&rft.aufirst=Constance&rft.date=2007-02-01&rft.volume=73&rft.issue=3&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Biochemical+Pharmacology&rft.issn=00062952&rft_id=info:doi/10.1016%2Fj.bcp.2006.10.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - NADH-ubiquinone oxidoreductase; Tumor cell lines; Cytotoxicity; Data processing; Cancer; Heart; Apoptosis; Antitumor activity; Electron transport chain; Mitochondria; Oxygen consumption; oxidoreductase; Databases; Tumors; Chemotherapy DO - http://dx.doi.org/10.1016/j.bcp.2006.10.005 ER - TY - JOUR T1 - Effects of Friedreich's ataxia (GAA) sub(n).(TTC) sub(n) repeats on RNA synthesis and stability AN - 19452290; 7408709 AB - Expansions of (GAA) sub(n) repeats within the first intron of the frataxin gene reduce its expression, resulting in a hereditary neurodegenerative disorder, Friedreich's ataxia. While it is generally believed that expanded (GAA) sub(n) repeats block transcription elongation, fine mechanisms responsible for gene repression are not fully understood. To follow the effects of (GAA) sub(n).(TTC) sub(n) repeats on gene expression, we have chosen E. coli as a convenient model system. (GAA) sub(n).(TTC) sub(n) repeats were cloned into bacterial plasmids in both orientations relative to a promoter, and their effects on transcription and RNA stability were evaluated both in vitro and in vivo. Expanded (GAA) sub(n) repeats in the sense strand for transcription caused a significant decrease in the mRNA levels in vitro and in vivo. This decrease was likely due to the tardiness of the RNA polymerase within expanded (GAA) sub(n) runs but was not accompanied by the enzyme's dissociation and premature transcription termination. Unexpectedly, positioning of normal- and carrier-size (TTC) sub(n) repeats into the sense strand for transcription led to the appearance of RNA transcripts that were truncated within those repetitive runs in vivo. We have determined that these RNA truncations are consistent with cleavage of the full-sized mRNAs at (UUC) sub(n) runs by the E. coli degradosome. JF - Nucleic Acids Research AU - Krasilnikova, Maria M AU - Kireeva, Maria L AU - Petrovic, Vladimir AU - Knijnikova, Nelli AU - Kashlev, Mikhail AU - Mirkin, Sergei M AD - Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA, NCI Center for Cancer Research, Frederick, MD 21702, USA and Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 1075 EP - 1084 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 35 IS - 4 SN - 0305-1048, 0305-1048 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; CSA Neurosciences Abstracts KW - Transcription termination KW - Transcription KW - Plasmids KW - Sensory systems KW - frataxin KW - Friedreich's ataxia KW - Gene expression KW - Neurodegenerative diseases KW - Promoters KW - DNA-directed RNA polymerase KW - Transcription elongation KW - Escherichia coli KW - Introns KW - Gene silencing KW - J 02310:Genetics & Taxonomy KW - N3 11023:Neurogenetics KW - N 14825:Gene Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19452290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Effects+of+Friedreich%27s+ataxia+%28GAA%29+sub%28n%29.%28TTC%29+sub%28n%29+repeats+on+RNA+synthesis+and+stability&rft.au=Krasilnikova%2C+Maria+M%3BKireeva%2C+Maria+L%3BPetrovic%2C+Vladimir%3BKnijnikova%2C+Nelli%3BKashlev%2C+Mikhail%3BMirkin%2C+Sergei+M&rft.aulast=Krasilnikova&rft.aufirst=Maria&rft.date=2007-02-01&rft.volume=35&rft.issue=4&rft.spage=1075&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Transcription termination; Transcription; Plasmids; Sensory systems; Friedreich's ataxia; frataxin; Gene expression; Promoters; Neurodegenerative diseases; DNA-directed RNA polymerase; Transcription elongation; Introns; Gene silencing; Escherichia coli ER - TY - JOUR T1 - A generic protocol for the expression and purification of recombinant proteins in Escherichia coli using a combinatorial His sub(6)-maltose binding protein fusion tag AN - 1439237980; 18477334 AB - We describe a generic protocol for the overproduction and purification of recombinant proteins in Escherichia coli. The strategy utilizes a dual His sub(6)-maltose binding protein (HisMBP) affinity tag that can be removed from the target protein by digestion of the fusion protein at a designed site by tobacco etch virus protease. The MBP moiety serves to enhance the solubility and promote the proper folding of its fusion partners, and the polyhistidine tag facilitates its purification to homogeneity. This protocol is divided into three stages, each of which takes approximately 1 week to complete: (i) construction of a HisMBP fusion vector; (ii) a pilot experiment to assess the yield and solubility of the target protein; and (iii) the large-scale production and purification of the target protein. JF - Nature Protocols AU - Nallamsetty, Sreedevi AU - Waugh, David S AD - Macromolecular Crystallography Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, P.O. Box B, Frederick, Maryland 21702-1201, USA. Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 383 EP - 391 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 2 IS - 2 SN - 1750-2799, 1750-2799 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Solubility KW - Escherichia coli KW - Tobacco etch virus KW - Proteinase KW - protein purification KW - Fusion protein KW - polyhistidine KW - J 02420:Plant Diseases KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1439237980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Protocols&rft.atitle=A+generic+protocol+for+the+expression+and+purification+of+recombinant+proteins+in+Escherichia+coli+using+a+combinatorial+His+sub%286%29-maltose+binding+protein+fusion+tag&rft.au=Nallamsetty%2C+Sreedevi%3BWaugh%2C+David+S&rft.aulast=Nallamsetty&rft.aufirst=Sreedevi&rft.date=2007-02-01&rft.volume=2&rft.issue=2&rft.spage=383&rft.isbn=&rft.btitle=&rft.title=Nature+Protocols&rft.issn=17502799&rft_id=info:doi/10.1038%2Fnprot.2007.50 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-10-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Solubility; Proteinase; Fusion protein; protein purification; polyhistidine; Escherichia coli; Tobacco etch virus DO - http://dx.doi.org/10.1038/nprot.2007.50 ER - TY - CPAPER T1 - Identification of Small RNAs Associated with the Gypsy Chromatin Insulator T2 - 2007 Keystone Symposia on MicroRNAs and siRNAs: Biological Functions and Mechanisms (J5) AN - 39341162; 4502388 JF - 2007 Keystone Symposia on MicroRNAs and siRNAs: Biological Functions and Mechanisms (J5) AU - Lei, Elissa Y1 - 2007/01/28/ PY - 2007 DA - 2007 Jan 28 KW - Chromatin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39341162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+MicroRNAs+and+siRNAs%3A+Biological+Functions+and+Mechanisms+%28J5%29&rft.atitle=Identification+of+Small+RNAs+Associated+with+the+Gypsy+Chromatin+Insulator&rft.au=Lei%2C+Elissa&rft.aulast=Lei&rft.aufirst=Elissa&rft.date=2007-01-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+MicroRNAs+and+siRNAs%3A+Biological+Functions+and+Mechanisms+%28J5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=82 5&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - RNAi and Heterochromatin Assembly in S. pombe T2 - 2007 Keystone Symposia on MicroRNAs and siRNAs: Biological Functions and Mechanisms (J5) AN - 39303795; 4502385 JF - 2007 Keystone Symposia on MicroRNAs and siRNAs: Biological Functions and Mechanisms (J5) AU - Grewal, Shiv I S Y1 - 2007/01/28/ PY - 2007 DA - 2007 Jan 28 KW - Heterochromatin KW - RNA-mediated interference KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39303795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+MicroRNAs+and+siRNAs%3A+Biological+Functions+and+Mechanisms+%28J5%29&rft.atitle=RNAi+and+Heterochromatin+Assembly+in+S.+pombe&rft.au=Grewal%2C+Shiv+I+S&rft.aulast=Grewal&rft.aufirst=Shiv+I&rft.date=2007-01-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+MicroRNAs+and+siRNAs%3A+Biological+Functions+and+Mechanisms+%28J5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=82 5&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - A "silent" polymorphism in the MDR1 gene changes substrate specificity. AN - 68949232; 17185560 AB - Synonymous single-nucleotide polymorphisms (SNPs) do not produce altered coding sequences, and therefore they are not expected to change the function of the protein in which they occur. We report that a synonymous SNP in the Multidrug Resistance 1 (MDR1) gene, part of a haplotype previously linked to altered function of the MDR1 gene product P-glycoprotein (P-gp), nonetheless results in P-gp with altered drug and inhibitor interactions. Similar mRNA and protein levels, but altered conformations, were found for wild-type and polymorphic P-gp. We hypothesize that the presence of a rare codon, marked by the synonymous polymorphism, affects the timing of cotranslational folding and insertion of P-gp into the membrane, thereby altering the structure of substrate and inhibitor interaction sites. JF - Science (New York, N.Y.) AU - Kimchi-Sarfaty, Chava AU - Oh, Jung Mi AU - Kim, In-Wha AU - Sauna, Zuben E AU - Calcagno, Anna Maria AU - Ambudkar, Suresh V AU - Gottesman, Michael M AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. kimchi@cber.fda.gov Y1 - 2007/01/26/ PY - 2007 DA - 2007 Jan 26 SP - 525 EP - 528 VL - 315 IS - 5811 KW - Codon KW - 0 KW - P-Glycoprotein KW - RNA, Messenger KW - Rhodamine 123 KW - 1N3CZ14C5O KW - Cyclosporine KW - 83HN0GTJ6D KW - Verapamil KW - CJ0O37KU29 KW - Sirolimus KW - W36ZG6FT64 KW - Index Medicus KW - Animals KW - Protein Biosynthesis KW - HeLa Cells KW - Humans KW - Verapamil -- pharmacology KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Rhodamine 123 -- pharmacology KW - Mutagenesis, Site-Directed KW - Rhodamine 123 -- metabolism KW - RNA, Messenger -- metabolism KW - Haplotypes KW - Transfection KW - Cyclosporine -- pharmacology KW - Verapamil -- metabolism KW - Sirolimus -- pharmacology KW - Cercopithecus aethiops KW - Substrate Specificity KW - Cell Membrane -- metabolism KW - Protein Structure, Tertiary KW - Cell Line KW - Protein Conformation KW - Polymorphism, Single Nucleotide KW - P-Glycoprotein -- genetics KW - P-Glycoprotein -- metabolism KW - Protein Folding KW - P-Glycoprotein -- chemistry KW - P-Glycoprotein -- antagonists & inhibitors KW - Genes, MDR UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68949232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28New+York%2C+N.Y.%29&rft.atitle=A+%22silent%22+polymorphism+in+the+MDR1+gene+changes+substrate+specificity.&rft.au=Kimchi-Sarfaty%2C+Chava%3BOh%2C+Jung+Mi%3BKim%2C+In-Wha%3BSauna%2C+Zuben+E%3BCalcagno%2C+Anna+Maria%3BAmbudkar%2C+Suresh+V%3BGottesman%2C+Michael+M&rft.aulast=Kimchi-Sarfaty&rft.aufirst=Chava&rft.date=2007-01-26&rft.volume=315&rft.issue=5811&rft.spage=525&rft.isbn=&rft.btitle=&rft.title=Science+%28New+York%2C+N.Y.%29&rft.issn=1095-9203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-06 N1 - Date created - 2007-01-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Science. 2007 Jan 26;315(5811):466-7 [17185559] Epilepsia. 2007 Dec;48(12):2369-70 [18088268] Bioessays. 2007 Jun;29(6):515-9 [17508390] Erratum In: Science. 2011 oCT 7;334(6052):39 Science. 2007 Nov 30;318(5855):1382-3 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A perspective on microarrays: current applications, pitfalls, and potential uses. AN - 68999129; 17254338 AB - With advances in robotics, computational capabilities, and the fabrication of high quality glass slides coinciding with increased genomic information being available on public databases, microarray technology is increasingly being used in laboratories around the world. In fact, fields as varied as: toxicology, evolutionary biology, drug development and production, disease characterization, diagnostics development, cellular physiology and stress responses, and forensics have benefiting from its use. However, for many researchers not familiar with microarrays, current articles and reviews often address neither the fundamental principles behind the technology nor the proper designing of experiments. Although, microarray technology is relatively simple, conceptually, its practice does require careful planning and detailed understanding of the limitations inherently present. Without these considerations, it can be exceedingly difficult to ascertain valuable information from microarray data. Therefore, this text aims to outline key features in microarray technology, paying particular attention to current applications as outlined in recent publications, experimental design, statistical methods, and potential uses. Furthermore, this review is not meant to be comprehensive, but rather substantive; highlighting important concepts and detailing steps necessary to conduct and interpret microarray experiments. Collectively, the information included in this text will highlight the versatility of microarray technology and provide a glimpse of what the future may hold. JF - Microbial cell factories AU - Jaluria, Pratik AU - Konstantopoulos, Konstantinos AU - Betenbaugh, Michael AU - Shiloach, Joseph AD - Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 221 Maryland Hall, 3400 North Charles Street, Baltimore, MD 21218, USA. pratikj@mail.nih.gov Y1 - 2007/01/25/ PY - 2007 DA - 2007 Jan 25 SP - 4 VL - 6 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68999129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+cell+factories&rft.atitle=A+perspective+on+microarrays%3A+current+applications%2C+pitfalls%2C+and+potential+uses.&rft.au=Jaluria%2C+Pratik%3BKonstantopoulos%2C+Konstantinos%3BBetenbaugh%2C+Michael%3BShiloach%2C+Joseph&rft.aulast=Jaluria&rft.aufirst=Pratik&rft.date=2007-01-25&rft.volume=6&rft.issue=&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Microbial+cell+factories&rft.issn=1475-2859&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-02 N1 - Date created - 2007-02-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14863-8 [9843981] PLoS Biol. 2006 Jul;4(8):e256 [16856782] Nat Genet. 1999 Jul;22(3):281-5 [10391217] J Immunol Methods. 2001 Apr1;250(1-2):93-112 [11251224] Nat Rev Genet. 2001 Jun;2(6):418-27 [11389458] Biotechniques. 2001 Jun;30(6):1322-6, 1328, 1330-1 [11414226] Acta Med Okayama. 2001 Dec;55(6):319-28 [11779093] Microcirculation. 2002 Jan;9(1):13-22 [11896556] N Engl J Med. 2002 Jun 20;346(25):1937-47 [12075054] Genet Epidemiol. 2002 Jun;23(1):21-36 [12112246] Curr Opin Pharmacol. 2002 Oct;2(5):551-4 [12324258] Adv Physiol Educ. 2002 Dec;26(1-4):256-70 [12443997] Nat Genet. 2002 Dec;32 Suppl:502-8 [12454645] Nat Rev Drug Discov. 2002 Dec;1(12):951-60 [12461517] Ann N Y Acad Sci. 2002 Dec;975:169-79 [12538163] J Clin Microbiol. 2003 Feb;41(2):632-9 [12574259] Mol Microbiol. 2003 Feb;47(4):879-89 [12581346] Bioinformatics. 2003 Mar 1;19(4):459-66 [12611800] Biotechniques. 2003 Feb;34(2):374-8 [12613259] RNA. 2003 May;9(5):518-32 [12702811] J Biol Chem. 2003 Aug 1;278(31):28388-94 [12743126] Curr Opin Drug Discov Devel. 2003 May;6(3):384-95 [12833672] PLoS Biol. 2003 Nov;1(2):E2 [14624234] Nucleic Acids Res. 2004;32(5):1848-56 [15037662] Curr Opin Microbiol. 2004 Jun;7(3):245-54 [15196491] J Bacteriol. 2004 Jul;186(13):4338-49 [15205436] J Microbiol Methods. 2004 Aug;58(2):251-62 [15234523] Appl Microbiol Biotechnol. 2004 Dec;66(2):123-30 [15316685] Mil Med. 2004 Aug;169(8):594-9 [15379069] Biotechnol Bioeng. 2005 Jan 20;89(2):195-205 [15580578] BMC Genomics. 2005;6:66 [15877823] Microb Cell Fact. 2005 Jun 28;4:19 [15985162] Water Res. 2005 Sep;39(14):3229-38 [16009395] Mol Biol Cell. 2005 Oct;16(10):4814-26 [16030247] Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14010-5 [16172382] J Ind Microbiol Biotechnol. 2006 Feb;33(2):159-72 [16217633] J Bacteriol. 2006 Jan;188(2):669-76 [16385056] J Clin Microbiol. 2006 Jan;44(1):244-50 [16390982] Crit Rev Microbiol. 2005;31(4):233-54 [16417203] Antimicrob Agents Chemother. 2006 May;50(5):1753-61 [16641446] J Bacteriol. 2006 May;188(10):3645-53 [16672618] Clin Exp Pharmacol Physiol. 2006 May-Jun;33(5-6):496-503 [16700885] Trends Ecol Evol. 2006 Jan;21(1):29-37 [16701467] BMC Genomics. 2006;7:117 [16709242] Neuropsychopharmacology. 2006 Oct;31(10):2304-12 [16710320] J Clin Microbiol. 2006 Jun;44(6):2212-9 [16757623] Nat Genet. 1999 Jan;21(1 Suppl):33-7 [9915498] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Cardiorespiratory and SAO sub(2) Changes Precede Apnea and Bradycardia Events during Infant Home Memory Monitoring T2 - 25th Annual Conference on Sleep Disorders in Infancy and Childhood AN - 39319448; 4551962 JF - 25th Annual Conference on Sleep Disorders in Infancy and Childhood AU - Hunt, C E AU - Corwin, M J AU - Weese-Mayer, D E AU - Ward, S.L.D. AU - Lister, G AU - Neuman, M R AU - Tinsley, L R AU - Ramanathan, R AU - Willinger, M Y1 - 2007/01/25/ PY - 2007 DA - 2007 Jan 25 KW - Residential areas KW - Infants KW - Sleep disorders KW - Apnea KW - Memory KW - Bradycardia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39319448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Conference+on+Sleep+Disorders+in+Infancy+and+Childhood&rft.atitle=Cardiorespiratory+and+SAO+sub%282%29+Changes+Precede+Apnea+and+Bradycardia+Events+during+Infant+Home+Memory+Monitoring&rft.au=Hunt%2C+C+E%3BCorwin%2C+M+J%3BWeese-Mayer%2C+D+E%3BWard%2C+S.L.D.%3BLister%2C+G%3BNeuman%2C+M+R%3BTinsley%2C+L+R%3BRamanathan%2C+R%3BWillinger%2C+M&rft.aulast=Hunt&rft.aufirst=C&rft.date=2007-01-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Conference+on+Sleep+Disorders+in+Infancy+and+Childhood&rft.issn=&rft_id=info:doi/ L2 - http://www.5starmeded.org/sleepdisorders/abstracts.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Image-guided, direct convective delivery of glucocerebrosidase for neuronopathic Gaucher disease. AN - 68937379; 17065591 AB - To determine if convection-enhanced delivery (CED) of glucocerebrosidase could be used to treat targeted sites of disease progression in the brain and brainstem of a patient with neuronopathic Gaucher disease while monitoring enzyme distribution using MRI. A CED paradigm in rodents (n = 8) and primates (n = 5) that employs co-infusion of a surrogate MRI tracer (gadolinium diethylenetriamine penta-acetic acid [Gd-DTPA]) with glucocerebrosidase to permit real-time monitoring of distribution was developed. The safety and feasibility of this delivery and monitoring paradigm were evaluated in a patient with type 2 Gaucher disease. Animal studies revealed that real-time, T1-weighted, MRI of Gd-DTPA accurately tracked enzyme distribution during CED. Targeted perfusion of clinically affected anatomic sites in a patient with neuronopathic Gaucher disease (frontal lobe and brainstem) with glucocerebrosidase was successfully performed. Real-time MRI revealed progressive and complete filling of the targeted region with enzyme and Gd-DTPA infusate. The patient tolerated the infusions without evidence of toxicity. Convection-enhanced delivery can be used to safely perfuse large regions of the brain and brainstem with therapeutic levels of glucocerebrosidase. Co-infused imaging surrogate tracers can be used to monitor and control the distribution of therapeutic agents in vivo. Patients with neuronopathic Gaucher disease and other intrinsic CNS disorders may benefit from a similar treatment paradigm. JF - Neurology AU - Lonser, R R AU - Schiffman, R AU - Robison, R A AU - Butman, J A AU - Quezado, Z AU - Walker, M L AU - Morrison, P F AU - Walbridge, S AU - Murray, G J AU - Park, D M AU - Brady, R O AU - Oldfield, E H AD - Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bldg. 10, Rm. 5D37, Bethesda, MD 20892-1414, USA. lonserr@ninds.nih.gov Y1 - 2007/01/23/ PY - 2007 DA - 2007 Jan 23 SP - 254 EP - 261 VL - 68 IS - 4 KW - Glucosylceramidase KW - EC 3.2.1.45 KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Infant KW - Animals KW - Rats, Sprague-Dawley KW - Neurons -- drug effects KW - Humans KW - Macaca mulatta KW - Radiography KW - Male KW - Neurons -- pathology KW - Convection KW - Surgery, Computer-Assisted -- methods KW - Glucosylceramidase -- administration & dosage KW - Gaucher Disease -- drug therapy KW - Gaucher Disease -- diagnostic imaging KW - Gaucher Disease -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68937379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Image-guided%2C+direct+convective+delivery+of+glucocerebrosidase+for+neuronopathic+Gaucher+disease.&rft.au=Lonser%2C+R+R%3BSchiffman%2C+R%3BRobison%2C+R+A%3BButman%2C+J+A%3BQuezado%2C+Z%3BWalker%2C+M+L%3BMorrison%2C+P+F%3BWalbridge%2C+S%3BMurray%2C+G+J%3BPark%2C+D+M%3BBrady%2C+R+O%3BOldfield%2C+E+H&rft.aulast=Lonser&rft.aufirst=R&rft.date=2007-01-23&rft.volume=68&rft.issue=4&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=1526-632X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-21 N1 - Date created - 2007-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Retrospective Cohort Study of Cumulative False Positive Risk for Lung Cancer Screening Test Among Tin Miners in Yunnan China T2 - Fourth Meeting of the Eastern Mediterranean Region of the International Biometric Society (EMR-IBS 2007) AN - 39329580; 4508525 JF - Fourth Meeting of the Eastern Mediterranean Region of the International Biometric Society (EMR-IBS 2007) AU - Hu, Ping Y1 - 2007/01/23/ PY - 2007 DA - 2007 Jan 23 KW - China, People's Rep. KW - Tin KW - Lung cancer KW - Occupational safety KW - Mining KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39329580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fourth+Meeting+of+the+Eastern+Mediterranean+Region+of+the+International+Biometric+Society+%28EMR-IBS+2007%29&rft.atitle=Retrospective+Cohort+Study+of+Cumulative+False+Positive+Risk+for+Lung+Cancer+Screening+Test+Among+Tin+Miners+in+Yunnan+China&rft.au=Hu%2C+Ping&rft.aulast=Hu&rft.aufirst=Ping&rft.date=2007-01-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fourth+Meeting+of+the+Eastern+Mediterranean+Region+of+the+International+Biometric+Society+%28EMR-IBS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congress.co.il/emr-ibs2007/progrem.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Imputation Methods for Adjusting for Covariate Measurement Error T2 - Fourth Meeting of the Eastern Mediterranean Region of the International Biometric Society (EMR-IBS 2007) AN - 39328953; 4508526 DE: JF - Fourth Meeting of the Eastern Mediterranean Region of the International Biometric Society (EMR-IBS 2007) AU - Kipnis, Victor Y1 - 2007/01/23/ PY - 2007 DA - 2007 Jan 23 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39328953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fourth+Meeting+of+the+Eastern+Mediterranean+Region+of+the+International+Biometric+Society+%28EMR-IBS+2007%29&rft.atitle=Imputation+Methods+for+Adjusting+for+Covariate+Measurement+Error&rft.au=Kipnis%2C+Victor&rft.aulast=Kipnis&rft.aufirst=Victor&rft.date=2007-01-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fourth+Meeting+of+the+Eastern+Mediterranean+Region+of+the+International+Biometric+Society+%28EMR-IBS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congress.co.il/emr-ibs2007/progrem.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Estimation of the Discrimination Ability of Biomarkers Subject to Limit of Detection T2 - Fourth Meeting of the Eastern Mediterranean Region of the International Biometric Society (EMR-IBS 2007) AN - 39299922; 4508519 JF - Fourth Meeting of the Eastern Mediterranean Region of the International Biometric Society (EMR-IBS 2007) AU - Schisterman, Enrique Y1 - 2007/01/23/ PY - 2007 DA - 2007 Jan 23 KW - Bioindicators KW - Discrimination KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39299922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fourth+Meeting+of+the+Eastern+Mediterranean+Region+of+the+International+Biometric+Society+%28EMR-IBS+2007%29&rft.atitle=Estimation+of+the+Discrimination+Ability+of+Biomarkers+Subject+to+Limit+of+Detection&rft.au=Schisterman%2C+Enrique&rft.aulast=Schisterman&rft.aufirst=Enrique&rft.date=2007-01-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fourth+Meeting+of+the+Eastern+Mediterranean+Region+of+the+International+Biometric+Society+%28EMR-IBS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congress.co.il/emr-ibs2007/progrem.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Deletion of KIS Accelerates Intimal Hyperplasia in Response to Vascular Injury and Enhances Migratory Activity of VSMC T2 - 2007 Keystone Symposia on Integrative Basis of Cardiovascular Disease (J4) AN - 39258927; 4506243 JF - 2007 Keystone Symposia on Integrative Basis of Cardiovascular Disease (J4) AU - Langenickel, Thomas H Y1 - 2007/01/22/ PY - 2007 DA - 2007 Jan 22 KW - Injuries KW - Recruitment KW - Vascular system KW - Deletion KW - Hyperplasia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39258927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Integrative+Basis+of+Cardiovascular+Disease+%28J4%29&rft.atitle=Deletion+of+KIS+Accelerates+Intimal+Hyperplasia+in+Response+to+Vascular+Injury+and+Enhances+Migratory+Activity+of+VSMC&rft.au=Langenickel%2C+Thomas+H&rft.aulast=Langenickel&rft.aufirst=Thomas&rft.date=2007-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Integrative+Basis+of+Cardiovascular+Disease+%28J4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=83 2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sequence Variation in Human Taste Receptors T2 - 2007 Keystone Symposia on Chemical Senses: From Genes to Perception (A7) AN - 39312878; 4502477 JF - 2007 Keystone Symposia on Chemical Senses: From Genes to Perception (A7) AU - Drayna, Dennis Y1 - 2007/01/21/ PY - 2007 DA - 2007 Jan 21 KW - Taste receptors KW - Taste KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39312878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Chemical+Senses%3A+From+Genes+to+Perception+%28A7%29&rft.atitle=Sequence+Variation+in+Human+Taste+Receptors&rft.au=Drayna%2C+Dennis&rft.aulast=Drayna&rft.aufirst=Dennis&rft.date=2007-01-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Chemical+Senses%3A+From+Genes+to+Perception+%28A7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 3&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Translating the Basic Science of Tumor-Host Interactions into New Human Immunotherapies T2 - 2007 Keystone Symposia on Host Cell Interaction and Response to the Cancer Cell (A8) AN - 39219974; 4502167 JF - 2007 Keystone Symposia on Host Cell Interaction and Response to the Cancer Cell (A8) AU - Restifo, Nicholas P Y1 - 2007/01/21/ PY - 2007 DA - 2007 Jan 21 KW - Immunotherapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39219974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Host+Cell+Interaction+and+Response+to+the+Cancer+Cell+%28A8%29&rft.atitle=Translating+the+Basic+Science+of+Tumor-Host+Interactions+into+New+Human+Immunotherapies&rft.au=Restifo%2C+Nicholas+P&rft.aulast=Restifo&rft.aufirst=Nicholas&rft.date=2007-01-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Host+Cell+Interaction+and+Response+to+the+Cancer+Cell+%28A8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=82 1&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lipid Regulators of IgE/Fc Epsilon Homeostasis and Function T2 - 2007 Keystone Symposia on Mast Cells, Basophils, and IgE: Host Defense and Disease (A6) AN - 39340932; 4502322 JF - 2007 Keystone Symposia on Mast Cells, Basophils, and IgE: Host Defense and Disease (A6) AU - Rivera, Juan Y1 - 2007/01/20/ PY - 2007 DA - 2007 Jan 20 KW - Lipids KW - Homeostasis KW - Fc KW - Immunoglobulin E KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39340932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Mast+Cells%2C+Basophils%2C+and+IgE%3A+Host+Defense+and+Disease+%28A6%29&rft.atitle=Lipid+Regulators+of+IgE%2FFc+Epsilon+Homeostasis+and+Function&rft.au=Rivera%2C+Juan&rft.aulast=Rivera&rft.aufirst=Juan&rft.date=2007-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Mast+Cells%2C+Basophils%2C+and+IgE%3A+Host+Defense+and+Disease+%28A6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 2&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of the Transmembrane Adaptor Protein (TRAP) NTAL/LAB/LAT2 (NTAL) in Mast Cell Activation T2 - 2007 Keystone Symposia on Mast Cells, Basophils, and IgE: Host Defense and Disease (A6) AN - 39321304; 4502303 JF - 2007 Keystone Symposia on Mast Cells, Basophils, and IgE: Host Defense and Disease (A6) AU - Tkaczyk, Christine Y1 - 2007/01/20/ PY - 2007 DA - 2007 Jan 20 KW - Mast cells KW - Acid phosphatase (tartrate-resistant) KW - Cell activation KW - Adaptor proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39321304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Mast+Cells%2C+Basophils%2C+and+IgE%3A+Host+Defense+and+Disease+%28A6%29&rft.atitle=Role+of+the+Transmembrane+Adaptor+Protein+%28TRAP%29+NTAL%2FLAB%2FLAT2+%28NTAL%29+in+Mast+Cell+Activation&rft.au=Tkaczyk%2C+Christine&rft.aulast=Tkaczyk&rft.aufirst=Christine&rft.date=2007-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Mast+Cells%2C+Basophils%2C+and+IgE%3A+Host+Defense+and+Disease+%28A6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 2&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sphingosine Kinases are Determinants of Mast Cell Function and Anaphylaxis T2 - 2007 Keystone Symposia on Mast Cells, Basophils, and IgE: Host Defense and Disease (A6) AN - 39313029; 4502327 JF - 2007 Keystone Symposia on Mast Cells, Basophils, and IgE: Host Defense and Disease (A6) AU - Olivera, Ana Y1 - 2007/01/20/ PY - 2007 DA - 2007 Jan 20 KW - Anaphylaxis KW - Mast cells KW - Sphingosine kinase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39313029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Mast+Cells%2C+Basophils%2C+and+IgE%3A+Host+Defense+and+Disease+%28A6%29&rft.atitle=Sphingosine+Kinases+are+Determinants+of+Mast+Cell+Function+and+Anaphylaxis&rft.au=Olivera%2C+Ana&rft.aulast=Olivera&rft.aufirst=Ana&rft.date=2007-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Mast+Cells%2C+Basophils%2C+and+IgE%3A+Host+Defense+and+Disease+%28A6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 2&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preservation of Innate and Acquired Immune Function in Mast Cells Following Radiation Exposure T2 - 2007 Keystone Symposia on Mast Cells, Basophils, and IgE: Host Defense and Disease (A6) AN - 39312921; 4502310 JF - 2007 Keystone Symposia on Mast Cells, Basophils, and IgE: Host Defense and Disease (A6) AU - Brown, Jared M Y1 - 2007/01/20/ PY - 2007 DA - 2007 Jan 20 KW - Mast cells KW - Immune response KW - Radiation KW - Preservation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39312921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Mast+Cells%2C+Basophils%2C+and+IgE%3A+Host+Defense+and+Disease+%28A6%29&rft.atitle=Preservation+of+Innate+and+Acquired+Immune+Function+in+Mast+Cells+Following+Radiation+Exposure&rft.au=Brown%2C+Jared+M&rft.aulast=Brown&rft.aufirst=Jared&rft.date=2007-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Mast+Cells%2C+Basophils%2C+and+IgE%3A+Host+Defense+and+Disease+%28A6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 2&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Studies of the biological properties of human beta-defensin 1. AN - 68422535; 17071614 AB - Defensins are small (30-45 amino acid residues) cationic proteins with broad antimicrobial activity against many bacteria and fungi, some enveloped viruses, and other activities such as chemoattraction of a range of different cell types to the sites of inflammation. These proteins represent attractive targets for developing novel antimicrobial agents and modulators of immune responses with therapeutic applicability. In this report, we present the results of functional and structural studies of 26 single-site mutants of human beta-defensin 1 (hBD1). All mutants were assayed for antimicrobial activity against Escherichia coli (ATCC strain 25922) and for chemotactic activity with CCR6-transfected HEK293 cells. To analyze the structural implications of mutagenesis and to verify the correctness of the disulfide connectivity, we used x-ray crystallography to conduct complete structural studies for 10 mutants in which the topology of disulfides was the same as in the native hBD1. Mutations did not induce significant changes of the tertiary structure, suggesting that the observed alterations of biological properties of the mutants were solely associated with changes in the respective side chains. We found that cationic residues located near the C terminus (Arg(29), Lys(31), Lys(33), and Lys(36)) of hBD1 define most of the anti-E. coli in vitro activity of this protein. In turn, nearly all mutations altering the CCR6-mediated chemotaxis are located at one area of the protein, defined by the N-terminal alpha-helical region (Asp(1)... Ser(8)) and a few topologically adjacent residues (Lys(22), Arg(29), and Lys(33)). These experimental results allow for the first time drafting of the CCR6-epitope for a defensin molecule. JF - The Journal of biological chemistry AU - Pazgier, Marzena AU - Prahl, Adam AU - Hoover, David M AU - Lubkowski, Jacek AD - Macromolecular Crystallography Laboratory, NCI, National Institutes of Health, Frederick, Maryland 21702, USA. Y1 - 2007/01/19/ PY - 2007 DA - 2007 Jan 19 SP - 1819 EP - 1829 VL - 282 IS - 3 SN - 0021-9258, 0021-9258 KW - DEFB1 protein, human KW - 0 KW - Disulfides KW - Epitopes KW - beta-Defensins KW - Serine KW - 452VLY9402 KW - Arginine KW - 94ZLA3W45F KW - Lysine KW - K3Z4F929H6 KW - Index Medicus KW - Escherichia coli -- metabolism KW - Lysine -- chemistry KW - Arginine -- chemistry KW - Humans KW - Amino Acid Sequence KW - Serine -- chemistry KW - Mutagenesis KW - Disulfides -- chemistry KW - Transfection KW - Molecular Sequence Data KW - Point Mutation KW - Crystallography, X-Ray KW - Epitopes -- chemistry KW - Protein Structure, Tertiary KW - beta-Defensins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68422535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Studies+of+the+biological+properties+of+human+beta-defensin+1.&rft.au=Pazgier%2C+Marzena%3BPrahl%2C+Adam%3BHoover%2C+David+M%3BLubkowski%2C+Jacek&rft.aulast=Pazgier&rft.aufirst=Marzena&rft.date=2007-01-19&rft.volume=282&rft.issue=3&rft.spage=1819&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-27 N1 - Date created - 2007-01-15 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 2NLF; PDB; 2NLG; 2NLD; 2NLE; 2NLQ; 2NLB; 2NLP; 2NLC; 2NLS; 2NLH N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Conformation of the HIV-1 Gag Protein in Solution AN - 19848254; 7246118 AB - A single multi-domain viral protein, termed Gag, is sufficient for assembly of retrovirus-like particles in mammalian cells. We have purified the human immunodeficiency virus type 1 (HIV-1) Gag protein (lacking myristate at its N terminus and the p6 domain at its C terminus) from bacteria. This protein is capable of assembly into virus-like particles in a defined in vitro system. We have reported that it is in monomer-dimer equilibrium in solution, and have described a mutant Gag protein that remains monomeric at high concentrations in solution. We report that the mutant protein retains several properties of wild-type Gag. This mutant enabled us to analyze solutions of monomeric protein. Hydrodynamic studies on the mutant protein showed that it is highly asymmetric, with a frictional ratio of 1.66. Small-angle neutron scattering (SANS) experiments confirmed its asymmetry and yielded an R sub(g) value of 34 A. Atomic-level structures of individual domains within Gag have previously been determined, but these domains are connected in Gag by flexible linkers. We constructed a series of models of the mutant Gag protein based on these domain structures, and tested each model computationally for its agreement with the experimental hydrodynamic and SANS data. The only models consistent with the data were those in which Gag was folded over, with its N-terminal matrix domain near its C-terminal nucleocapsid domain in three-dimensional space. Since Gag is a rod-shaped molecule in the assembled immature virion, these findings imply that Gag undergoes a major conformational change upon virus assembly. JF - Journal of Molecular Biology AU - Datta, SAK AU - Curtis, JE AU - Ratcliff, W AU - Clark, P K AU - Crist, R M AU - Lebowitz, J AU - Krueger, S AU - Rein, A AD - National Cancer Institute-Frederick, Frederick, MD 21702-1201, USA, rein@ncifcrf.gov Y1 - 2007/01/19/ PY - 2007 DA - 2007 Jan 19 SP - 812 EP - 824 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 365 IS - 3 SN - 0022-2836, 0022-2836 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Virions KW - Virus-like particles KW - Data processing KW - Hydrodynamics KW - Mammalian cells KW - Neutron scattering KW - Human immunodeficiency virus 1 KW - Asymmetry KW - Nucleocapsids KW - Gag protein KW - J 02310:Genetics & Taxonomy KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19848254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Conformation+of+the+HIV-1+Gag+Protein+in+Solution&rft.au=Datta%2C+SAK%3BCurtis%2C+JE%3BRatcliff%2C+W%3BClark%2C+P+K%3BCrist%2C+R+M%3BLebowitz%2C+J%3BKrueger%2C+S%3BRein%2C+A&rft.aulast=Datta&rft.aufirst=SAK&rft.date=2007-01-19&rft.volume=365&rft.issue=3&rft.spage=812&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2006.10.073 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Virions; Data processing; Virus-like particles; Mammalian cells; Hydrodynamics; Neutron scattering; Asymmetry; Nucleocapsids; Gag protein; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1016/j.jmb.2006.10.073 ER - TY - CPAPER T1 - Positional Stability of Single Double Strand Breaks in Living Mammalian Cells T2 - 2007 Keystone Symposia on Genome Instability and Repair (A5) AN - 39313977; 4502113 JF - 2007 Keystone Symposia on Genome Instability and Repair (A5) AU - Soutoglou, Evi Y1 - 2007/01/17/ PY - 2007 DA - 2007 Jan 17 KW - Mammalian cells KW - Stranding KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39313977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Genome+Instability+and+Repair+%28A5%29&rft.atitle=Positional+Stability+of+Single+Double+Strand+Breaks+in+Living+Mammalian+Cells&rft.au=Soutoglou%2C+Evi&rft.aulast=Soutoglou&rft.aufirst=Evi&rft.date=2007-01-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Genome+Instability+and+Repair+%28A5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=82 8&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - p53 Biological Network: Inflammation, microRNA and Cancer T2 - 2007 Keystone Symposia on Genome Instability and Repair (A5) AN - 39299464; 4502077 JF - 2007 Keystone Symposia on Genome Instability and Repair (A5) AU - Harris, Curtis C Y1 - 2007/01/17/ PY - 2007 DA - 2007 Jan 17 KW - Cancer KW - MiRNA KW - P53 protein KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39299464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Genome+Instability+and+Repair+%28A5%29&rft.atitle=p53+Biological+Network%3A+Inflammation%2C+microRNA+and+Cancer&rft.au=Harris%2C+Curtis+C&rft.aulast=Harris&rft.aufirst=Curtis&rft.date=2007-01-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Genome+Instability+and+Repair+%28A5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=82 8&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationship between DNA Damage Detection and Signaling In Vivo T2 - 2007 Keystone Symposia on Genome Instability and Repair (A5) AN - 39250793; 4502130 JF - 2007 Keystone Symposia on Genome Instability and Repair (A5) AU - Nussenzweig, Andre Y1 - 2007/01/17/ PY - 2007 DA - 2007 Jan 17 KW - Signal transduction KW - DNA damage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39250793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Genome+Instability+and+Repair+%28A5%29&rft.atitle=Relationship+between+DNA+Damage+Detection+and+Signaling+In+Vivo&rft.au=Nussenzweig%2C+Andre&rft.aulast=Nussenzweig&rft.aufirst=Andre&rft.date=2007-01-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Genome+Instability+and+Repair+%28A5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=82 8&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Premature Aging and DNA Repair T2 - 2007 Keystone Symposia on Genome Instability and Repair (A5) AN - 39247649; 4502120 JF - 2007 Keystone Symposia on Genome Instability and Repair (A5) AU - Bohr, Vilhelm A Y1 - 2007/01/17/ PY - 2007 DA - 2007 Jan 17 KW - Aging KW - DNA repair KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39247649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Genome+Instability+and+Repair+%28A5%29&rft.atitle=Human+Premature+Aging+and+DNA+Repair&rft.au=Bohr%2C+Vilhelm+A&rft.aulast=Bohr&rft.aufirst=Vilhelm&rft.date=2007-01-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Genome+Instability+and+Repair+%28A5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=82 8&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Controlling the Outcome of Meiotic Double-Strand Break Repair T2 - 2007 Keystone Symposia on Genome Instability and Repair (A5) AN - 39241734; 4502083 JF - 2007 Keystone Symposia on Genome Instability and Repair (A5) AU - Lichten, Michael J Y1 - 2007/01/17/ PY - 2007 DA - 2007 Jan 17 KW - Meiosis KW - Double-strand break repair KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39241734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Genome+Instability+and+Repair+%28A5%29&rft.atitle=Controlling+the+Outcome+of+Meiotic+Double-Strand+Break+Repair&rft.au=Lichten%2C+Michael+J&rft.aulast=Lichten&rft.aufirst=Michael&rft.date=2007-01-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Genome+Instability+and+Repair+%28A5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=82 8&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biochemical Analysis of LRRK2 Parkinsons Disease Associated Mutations T2 - 2007 Keystone Symposia on Molecular Mechanisms of Neurodegeneration (A4) AN - 39265447; 4502428 JF - 2007 Keystone Symposia on Molecular Mechanisms of Neurodegeneration (A4) AU - Lewis, Patrick A Y1 - 2007/01/16/ PY - 2007 DA - 2007 Jan 16 KW - Mutation KW - Biochemical analysis KW - Movement disorders KW - Neurodegenerative diseases KW - Parkinson's disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39265447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Molecular+Mechanisms+of+Neurodegeneration+%28A4%29&rft.atitle=Biochemical+Analysis+of+LRRK2+Parkinsons+Disease+Associated+Mutations&rft.au=Lewis%2C+Patrick+A&rft.aulast=Lewis&rft.aufirst=Patrick&rft.date=2007-01-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Molecular+Mechanisms+of+Neurodegeneration+%28A4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 1&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Lymphocyte Loss and Immunosuppression Following Acetaminophen-Induced Hepatotoxicity in Mice as a Potential Mechanism of Tolerance AN - 19554419; 7264361 AB - Current evidence suggests that drag-induced liver disease can be caused by an allergic response (drag-induced allergic hepatitis, DIAH) induced by hepatic drag-protein adducts. The relatively low incidence of these reactions has led us to hypothesize that tolerogenic mechanisms prevent DIAH from occurring in most people. Here, we present evidence for the existence of one of these regulatory pathways. Following a hepatotoxic dose of acetaminophen in C57B1/6 mice, lymphocyte loss that appeared to be due at least in part to apoptosis was noted in the spleen, thymus, and draining lymph nodes of the liver. There was no observable lymphocyte loss in the absence of hepatotoxicity. Acetaminophen-induced liver injury (AILI) also led to a functional suppression of the immune system as determined by the inhibition of a delayed-type hypersensitivity response to dinitrochlorobenzene. Further studies with adrenalectomized mice suggested a role for corticosterone in the depletion of lymphocytes following APAP-induced liver injury. In conclusion, these findings suggest that lymphocyte loss and immunosuppression following AILI may prevent subsequent occurrences of allergic hepatitis and possibly other forms of APAP-induced allergies induced by hepatic drag-protein adducts. Similar regulatory pathways may inhibit other hepatotoxic drags from causing allergic reactions. JF - Chemical Research in Toxicology AU - Masson, MJ AU - Peterson, R A AU - Chung, C J AU - Graf, M L AU - Carpenter, L D AU - Ambroso, J L AU - Krull, D L AU - Sciarrotta, J AU - Pohl, L R AD - Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2007/01/16/ PY - 2007 DA - 2007 Jan 16 SP - 20 EP - 26 VL - 20 IS - 1 SN - 0893-228X, 0893-228X KW - Virology & AIDS Abstracts; Toxicology Abstracts; Immunology Abstracts KW - Liver diseases KW - Apoptosis KW - Injuries KW - Immune system KW - Adducts KW - Thymus KW - Spleen KW - Lymphocytes KW - Immunological tolerance KW - hepatotoxicity KW - Lymph nodes KW - Hepatitis KW - Corticosterone KW - Hypersensitivity KW - Hypersensitivity (delayed) KW - Acetaminophen KW - Immunosuppression KW - F 06925:Hypersensitivity KW - X 24310:Pharmaceuticals KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19554419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Research+in+Toxicology&rft.atitle=Lymphocyte+Loss+and+Immunosuppression+Following+Acetaminophen-Induced+Hepatotoxicity+in+Mice+as+a+Potential+Mechanism+of+Tolerance&rft.au=Masson%2C+MJ%3BPeterson%2C+R+A%3BChung%2C+C+J%3BGraf%2C+M+L%3BCarpenter%2C+L+D%3BAmbroso%2C+J+L%3BKrull%2C+D+L%3BSciarrotta%2C+J%3BPohl%2C+L+R&rft.aulast=Masson&rft.aufirst=MJ&rft.date=2007-01-16&rft.volume=20&rft.issue=1&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Chemical+Research+in+Toxicology&rft.issn=0893228X&rft_id=info:doi/10.1021%2Ftx060190c LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Apoptosis; Liver diseases; Injuries; Adducts; Immune system; Thymus; Spleen; Lymphocytes; Immunological tolerance; Lymph nodes; hepatotoxicity; Hepatitis; Corticosterone; Hypersensitivity; Hypersensitivity (delayed); Acetaminophen; Immunosuppression DO - http://dx.doi.org/10.1021/tx060190c ER - TY - JOUR T1 - Assessing the role of DRD5 and DYT1 in two different case-control series with primary blepharospasm. AN - 85399557; pmid-17133500 AB - Primary blepharospasm is a common adult-onset focal dystonia. Polymorphisms of the genes encoding TorsinA (DYT1) and the D5 dopamine receptor (DRD5) have previously been associated with lifetime risk for focal dystonia. We describe here experiments testing common variability within these two genes in two independent cohorts of Italian and North American patients with primary blepharospasm. We have failed to identify a consistent association with disease in the two patient groups examined here; however, analysis of the Italian group reveals an association with the same risk genotype in DYT1 as previously described in an Icelandic population. We have also found global significant DYT1 haplotype differences between patients and controls in the Italian series. These data suggest that further examination is warranted of the role genetic variability at this locus plays in the risk for primary dystonia.(c) 2006 Movement Disorder Society. JF - Movement disorders : official journal of the Movement Disorder Society AU - Clarimon, Jordi AU - Brancati, Francesco AU - Peckham, Elizabeth AU - Valente, Enza Maria AU - Dallapiccola, Bruno AU - Abruzzese, Giovanni AU - Girlanda, Paolo AU - Defazio, Giovanni AU - Berardelli, Alfredo AU - Hallett, Mark AU - Singleton, Andrew B AD - Molecular Genetics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA. jclarimon@santpau.es Y1 - 2007/01/15/ PY - 2007 DA - 2007 Jan 15 SP - 162 EP - 166 VL - 22 IS - 2 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Blepharospasm: diagnosis KW - *Blepharospasm: genetics KW - *Blepharospasm: physiopathology KW - Case-Control Studies KW - DNA Primers: genetics KW - Female KW - Gene Frequency KW - Genotype KW - Humans KW - Linkage Disequilibrium: genetics KW - Male KW - Microsatellite Repeats: genetics KW - Middle Aged KW - Molecular Chaperones: genetics KW - *Molecular Chaperones: physiology KW - Polymerase Chain Reaction KW - Polymorphism, Genetic: genetics KW - Receptors, Dopamine D5: genetics KW - *Receptors, Dopamine D5: physiology KW - Severity of Illness Index UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85399557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Assessing+the+role+of+DRD5+and+DYT1+in+two+different+case-control+series+with+primary+blepharospasm.&rft.au=Clarimon%2C+Jordi%3BBrancati%2C+Francesco%3BPeckham%2C+Elizabeth%3BValente%2C+Enza+Maria%3BDallapiccola%2C+Bruno%3BAbruzzese%2C+Giovanni%3BGirlanda%2C+Paolo%3BDefazio%2C+Giovanni%3BBerardelli%2C+Alfredo%3BHallett%2C+Mark%3BSingleton%2C+Andrew+B&rft.aulast=Clarimon&rft.aufirst=Jordi&rft.date=2007-01-15&rft.volume=22&rft.issue=2&rft.spage=162&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Helicobacter pylori and oesophageal and gastric cancers in a prospective study in China AN - 807271747; 13759737 AB - In a cohort of 29584 residents of Linxian, China, followed from 1985 to 2001, we conducted a case-cohort study of the magnitude of the association of Helicobacter pylori seropositivity with cancer risk in a random sample of 300 oesophageal squamous cell carcinomas, 600 gastric cardia adenocarcinomas, all 363 diagnosed gastric non-cardia adenocarcinomas, and a random sample of the entire cohort (N=1050). Baseline serum was evaluated for IgG antibodies to whole-cell and CagA H. pylori antigens by enzyme-linked immunosorbent assay. Risks of both gastric cardia and non-cardia cancers were increased in individuals exposed to H. pylori (Hazard ratios (HRs) and 95% confidence intervals=1.64; 1.26-2.14, and 1.60; 1.15-2.21, respectively), whereas risk of oesophageal squamous cell cancer was not affected (1.17; 0.88-1.57). For both cardia and non-cardia cancers, HRs were higher in younger individuals. With longer time between serum collection to cancer diagnosis, associations became stronger for cardia cancers but weaker for non-cardia cancers. CagA positivity did not modify these associations. The associations between H. pylori exposure and gastric cardia and non-cardia adenocarcinoma development were equally strong, in contrast to Western countries, perhaps due to the absence of Barrett's oesophagus and oesophageal adenocarcinomas in Linxian, making all cardia tumours of gastric origin, rather than a mixture of gastric and oesophageal malignancies.British Journal of Cancer (2007) 96, 172-176. doi doi:10.1038/sj.bjc.6603517 www.bjcancer.com Published online 19 December 2006 JF - British Journal of Cancer AU - Kamangar, F AU - Qiao, Y-L AU - Blaser, M J AU - Sun, X-D AU - Katki, H AU - Fan, J-H AU - Perez-Perez, G I AU - Abnet, C C AU - Zhao, P AU - Mark, S D AU - Taylor, P R AU - Dawsey, S M AD - 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 3034, Bethesda, MD 20892-7232, USA Y1 - 2007/01/15/ PY - 2007 DA - 2007 Jan 15 SP - 172 EP - 176 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 96 IS - 1 SN - 0007-0920, 0007-0920 KW - Microbiology Abstracts B: Bacteriology; Risk Abstracts KW - Risk assessment KW - Esophagus KW - Helicobacter pylori KW - Enzyme-linked immunosorbent assay KW - Medical research KW - tumors KW - squamous cell carcinoma KW - Tumors KW - Cancer KW - Immunoglobulin G KW - China, People's Rep. KW - Gastrointestinal tract KW - Adenocarcinoma KW - Gastric cancer KW - Immunoassays KW - Internet KW - R2 23060:Medical and environmental health KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807271747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Helicobacter+pylori+and+oesophageal+and+gastric+cancers+in+a+prospective+study+in+China&rft.au=Kamangar%2C+F%3BQiao%2C+Y-L%3BBlaser%2C+M+J%3BSun%2C+X-D%3BKatki%2C+H%3BFan%2C+J-H%3BPerez-Perez%2C+G+I%3BAbnet%2C+C+C%3BZhao%2C+P%3BMark%2C+S+D%3BTaylor%2C+P+R%3BDawsey%2C+S+M&rft.aulast=Kamangar&rft.aufirst=F&rft.date=2007-01-15&rft.volume=96&rft.issue=1&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6603517 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Esophagus; Enzyme-linked immunosorbent assay; Immunoglobulin G; squamous cell carcinoma; Tumors; Gastric cancer; Adenocarcinoma; Internet; Risk assessment; Medical research; tumors; Gastrointestinal tract; Immunoassays; Cancer; Helicobacter pylori; China, People's Rep. DO - http://dx.doi.org/10.1038/sj.bjc.6603517 ER - TY - CPAPER T1 - CODs (Clusters of Orthologous Domains) - New Resource for Comparative Genomics of Eukaryotes T2 - XV Conference on Plant and Animal Genome (PAG-XV) AN - 39342886; 4507544 JF - XV Conference on Plant and Animal Genome (PAG-XV) AU - Mekhedov, Sergei Y1 - 2007/01/13/ PY - 2007 DA - 2007 Jan 13 KW - Chemical oxygen demand KW - Genomics KW - Marine fish KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39342886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XV+Conference+on+Plant+and+Animal+Genome+%28PAG-XV%29&rft.atitle=CODs+%28Clusters+of+Orthologous+Domains%29+-+New+Resource+for+Comparative+Genomics+of+Eukaryotes&rft.au=Mekhedov%2C+Sergei&rft.aulast=Mekhedov&rft.aufirst=Sergei&rft.date=2007-01-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XV+Conference+on+Plant+and+Animal+Genome+%28PAG-XV%29&rft.issn=&rft_id=info:doi/ L2 - http://www.intl-pag.org/15/15-workshops.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gnomon a Multi-Step Combined Gene Prediction Program T2 - XV Conference on Plant and Animal Genome (PAG-XV) AN - 39259102; 4507125 JF - XV Conference on Plant and Animal Genome (PAG-XV) AU - Souvorov, Alexander Y1 - 2007/01/13/ PY - 2007 DA - 2007 Jan 13 KW - Bioinformatics KW - Computer programs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39259102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XV+Conference+on+Plant+and+Animal+Genome+%28PAG-XV%29&rft.atitle=Gnomon+a+Multi-Step+Combined+Gene+Prediction+Program&rft.au=Souvorov%2C+Alexander&rft.aulast=Souvorov&rft.aufirst=Alexander&rft.date=2007-01-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XV+Conference+on+Plant+and+Animal+Genome+%28PAG-XV%29&rft.issn=&rft_id=info:doi/ L2 - http://www.intl-pag.org/15/15-workshops.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Serotonergic responsiveness in human cocaine users. AN - 68363101; 16930852 AB - Animal experiments show that repeated cocaine injections induce changes in brain serotonin (5-hydroxytryptamine, or 5-HT) function which can be detected by altered neuroendocrine responsiveness to serotonergic drug challenge. Studies of human cocaine users given a serotonergic challenge have produced inconsistent results. Hormone responses evoked by the 5-HT releaser D,L-fenfluramine (FEN) were examined in eight human cocaine users who resided on a closed research ward. FEN (60 mg oral) was given after a 7-day cocaine-free period and 3 days after a 5-day period of daily double-blind administration of intranasal cocaine (96 mg) and active placebo (4 mg cocaine). Plasma cortisol and prolactin levels were measured after FEN challenges, and after cocaine and placebo administration. Cocaine significantly elevated plasma cortisol levels to a similar degree on the first and fifth days of administration, but did not alter prolactin levels on either day. The first FEN challenge significantly increased plasma prolactin and cortisol, whereas the second challenge increased only prolactin. Intranasal cocaine increases plasma cortisol without affecting prolactin, with no evidence for tolerance. The reduction in FEN-induced cortisol secretion after cocaine exposure suggests that deficits in 5-HT transmission during early cocaine abstinence might contribute to the maintenance of drug dependence. JF - Drug and alcohol dependence AU - Ghitza, Udi E AU - Rothman, Richard B AU - Gorelick, David A AU - Henningfield, Jack E AU - Baumann, Michael H AD - Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2007/01/12/ PY - 2007 DA - 2007 Jan 12 SP - 207 EP - 213 VL - 86 IS - 2-3 SN - 0376-8716, 0376-8716 KW - Dopamine Uptake Inhibitors KW - 0 KW - Serotonin Agents KW - Fenfluramine KW - 2DS058H2CF KW - Serotonin KW - 333DO1RDJY KW - Prolactin KW - 9002-62-4 KW - Cocaine KW - I5Y540LHVR KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Prolactin -- blood KW - Humans KW - Adult KW - Time Factors KW - Male KW - Hydrocortisone -- blood KW - Female KW - Fenfluramine -- administration & dosage KW - Serotonin -- physiology KW - Serotonin Agents -- administration & dosage KW - Dopamine Uptake Inhibitors -- administration & dosage KW - Cocaine-Related Disorders -- physiopathology KW - Cocaine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68363101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Serotonergic+responsiveness+in+human+cocaine+users.&rft.au=Ghitza%2C+Udi+E%3BRothman%2C+Richard+B%3BGorelick%2C+David+A%3BHenningfield%2C+Jack+E%3BBaumann%2C+Michael+H&rft.aulast=Ghitza&rft.aufirst=Udi&rft.date=2007-01-12&rft.volume=86&rft.issue=2-3&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-21 N1 - Date created - 2006-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - DSM-IV alcohol dependence and abuse: further evidence of validity in the general population. AN - 68363045; 16814489 AB - In order to understand the validity of the Diagnostic and Statistical Manual of Mental Disorders, 4th ed. (DSM-IV) alcohol abuse and dependence diagnoses, studies are needed in both clinical and general population samples. The purpose of this study was to examine the construct and criterion-oriented validity of DSM-IV alcohol dependence and abuse in the general population with respect to factor structure and their relationship to family history of alcoholism, treatment utilization, and psychiatric comorbidity. This analysis is based on data from the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), in which nationally representative data were collected in personal interviews conducted with one randomly selected adult in each sample household or group quarters. A subset (n=26,946) of the NESARC sample (total n=43,093) who reported drinking one or more drinks during the year preceding the interview formed the basis of analyses. Latent variable modeling was used to assess the concurrent validity of DSM-IV alcohol abuse and dependence symptom items. The latent variable modeling yielded one major factor related to alcohol dependence, a second factor related to alcohol abuse and a third smaller factor defined by tolerance. The validity of alcohol dependence in general population samples was further supported by statistically significant associations with family history of alcoholism, treatment utilization, and psychiatric and medical comorbidities. The factor structure and relationship to external criterion variables observed in the study provide support for the further validity of DSM-IV alcohol dependence in the general population, whereas support for the validity of DSM-IV abuse was equivocal. JF - Drug and alcohol dependence AU - Grant, Bridget F AU - Harford, Thomas C AU - Muthén, Bengt O AU - Yi, Hsiao-ye AU - Hasin, Deborah S AU - Stinson, Frederick S AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-9304, USA. bgrant@willco.niaaa.nih.gov Y1 - 2007/01/12/ PY - 2007 DA - 2007 Jan 12 SP - 154 EP - 166 VL - 86 IS - 2-3 SN - 0376-8716, 0376-8716 KW - Index Medicus KW - Reproducibility of Results KW - Epidemiologic Studies KW - Humans KW - Health Surveys KW - Adult KW - Aged KW - Models, Statistical KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Diagnostic and Statistical Manual of Mental Disorders KW - Alcohol-Related Disorders -- diagnosis KW - Alcohol-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68363045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=DSM-IV+alcohol+dependence+and+abuse%3A+further+evidence+of+validity+in+the+general+population.&rft.au=Grant%2C+Bridget+F%3BHarford%2C+Thomas+C%3BMuth%C3%A9n%2C+Bengt+O%3BYi%2C+Hsiao-ye%3BHasin%2C+Deborah+S%3BStinson%2C+Frederick+S&rft.aulast=Grant&rft.aufirst=Bridget&rft.date=2007-01-12&rft.volume=86&rft.issue=2-3&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-21 N1 - Date created - 2006-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - SRF is a nuclear repressor of Smad3-mediated TGF-beta signaling. AN - 68418819; 16819512 AB - Serum response factor (SRF) is a widely expressed transcription factor involved in immediate-early and tissue-specific gene expression, cell proliferation and differentiation. We defined a new role of SRF as a nuclear repressor of the tumor growth factor beta1 (TGF-beta1) growth-inhibitory signal during cell proliferation. We show that SRF significantly inhibits the TGF-beta1/Smad-dependent transcription by associating with Smad3. SRF causes resistance to the TGF-beta1 cytostatic response by directly repressing the Smad transcriptional activity and Smad binding to DNA. Furthermore, we demonstrated that overexpression of SRF markedly decreases the level of Smad3 complex binding to the promoters of Smad3 target genes, p15(INK4b) and p21(Cip1). This leads to the inhibition of expression of TGF-beta1-responsive genes. SRF therefore acts as a nuclear repressor of Smad3-mediated TGF-beta1 signaling. JF - Oncogene AU - Lee, H-J AU - Yun, C-H AU - Lim, S H AU - Kim, B-C AU - Baik, K G AU - Kim, J-M AU - Kim, W-H AU - Kim, S-J AD - Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, MD 20892-5055, USA. Y1 - 2007/01/11/ PY - 2007 DA - 2007 Jan 11 SP - 173 EP - 185 VL - 26 IS - 2 SN - 0950-9232, 0950-9232 KW - CDKN1A protein, human KW - 0 KW - Cyclin-Dependent Kinase Inhibitor p15 KW - Cyclin-Dependent Kinase Inhibitor p21 KW - Repressor Proteins KW - Serum Response Factor KW - Smad3 Protein KW - Transforming Growth Factor beta1 KW - Index Medicus KW - Liver Neoplasms -- metabolism KW - HeLa Cells KW - Humans KW - Lung -- cytology KW - Transcriptional Activation KW - Epithelial Cells -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - Liver Neoplasms -- pathology KW - Cells, Cultured KW - Carcinoma, Hepatocellular -- pathology KW - Cyclin-Dependent Kinase Inhibitor p21 -- metabolism KW - Kidney -- cytology KW - Promoter Regions, Genetic -- genetics KW - Gene Expression Regulation KW - Cyclin-Dependent Kinase Inhibitor p15 -- metabolism KW - Serum Response Factor -- genetics KW - Smad3 Protein -- metabolism KW - Repressor Proteins -- metabolism KW - Transforming Growth Factor beta1 -- pharmacology KW - Transcription, Genetic KW - Serum Response Factor -- metabolism KW - Repressor Proteins -- genetics KW - Signal Transduction KW - Smad3 Protein -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68418819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=SRF+is+a+nuclear+repressor+of+Smad3-mediated+TGF-beta+signaling.&rft.au=Lee%2C+H-J%3BYun%2C+C-H%3BLim%2C+S+H%3BKim%2C+B-C%3BBaik%2C+K+G%3BKim%2C+J-M%3BKim%2C+W-H%3BKim%2C+S-J&rft.aulast=Lee&rft.aufirst=H-J&rft.date=2007-01-11&rft.volume=26&rft.issue=2&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-08 N1 - Date created - 2007-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Elevated risk of lung cancer among people with AIDS AN - 21035617; 7296538 AB - Background and objectives: Lung cancer is a common malignancy among people with AIDS (PWA). Lung cancer risk was compared between PWA and the general population and its relationship with immunosuppression was assessed. The likelihood that excess risk is explained by a high prevalence of smoking was also investigated. Methods: Records on adolescent and adult PWA (N = 397927) were linked with cancer registries in 11 US regions. Cancer risk was assessed for the period 60 months before to 60 months after AIDS onset, with specific emphasis on the period 4-27 months after onset. Observed incidence was compared with general population rates and rates from a lung cancer prediction model for smokers. Results: Compared with the general population, lung cancer risk among PWA was elevated overall [n = 1489 cases; standardized incidence ratio (SIR), 3.8; 95% confidence interval (CI), 3.6-4.1 ] and in the 4-27 months after AIDS (n = 393 cases; SIR, 2.9; 95% CI, 2.6-3.2). In the 4-27 months after AIDS, risk was significantly elevated for all demographic subgroups, and was especially high among young PWA (SIRs for ages 15-29 years, 10.4; 30-39 years, 6.3; 40-49 years, 3.7). Lung cancers generally presented at an advanced stage. Risk was not associated with CD4 cell counts at AIDS (P sub(trend) = 0.36). Under plausible smoking assumptions, observed incidence was significantly higher than predicted among 40-49 and 50-59-year-old men with AIDS (observed/ predicted =5.03 and 1.43, respectively) and 40-49-year-old women with AIDS (observed/predicted = 1.88), but not among older PWA. Conclusion: Lung cancer risk was substantially elevated among PWA. Smoking could not entirely account for the observed elevation, especially among younger adults, suggesting a role for additional co-factors. JF - AIDS AU - Chaturvedi, A K AU - Pfeiffer, R M AU - Chang, L AU - Goedert, J J AU - Biggar, R J AU - Engels, E A AD - Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 7072, Rockville, MD 20852, USA, chaturva@mail.nih.gov Y1 - 2007/01/11/ PY - 2007 DA - 2007 Jan 11 SP - 207 EP - 213 VL - 21 IS - 2 SN - 0269-9370, 0269-9370 KW - Immunology Abstracts; Risk Abstracts; Virology & AIDS Abstracts KW - demography KW - Acquired immune deficiency syndrome KW - Age KW - Adolescence KW - Demography KW - Smoking KW - Malignancy KW - CD4 antigen KW - prediction models KW - Adolescents KW - Lung cancer KW - Immunosuppression KW - V 22360:AIDS and HIV KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21035617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Elevated+risk+of+lung+cancer+among+people+with+AIDS&rft.au=Chaturvedi%2C+A+K%3BPfeiffer%2C+R+M%3BChang%2C+L%3BGoedert%2C+J+J%3BBiggar%2C+R+J%3BEngels%2C+E+A&rft.aulast=Chaturvedi&rft.aufirst=A&rft.date=2007-01-11&rft.volume=21&rft.issue=2&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Demography; Smoking; Age; CD4 antigen; Malignancy; Acquired immune deficiency syndrome; Adolescence; Immunosuppression; Lung cancer; demography; prediction models; Adolescents ER - TY - JOUR T1 - Chimeric rabbit/human Fab and IgG specific for members of the Nogo-66 receptor family selected for species cross-reactivity with an improved phage display vector AN - 19850283; 7273486 AB - NgR1, NgR2, and NgR3 which constitute the Nogo-66 receptor family are primarily expressed by neurons in the central nervous system (CNS) and believed to limit axonal growth and sprouting following CNS injury. In an attempt to define the expression and decipher the function of individual members of the Nogo-66 receptor family, we previously reported the generation of selective rabbit polyclonal antibodies. Here we exploit the same immune repertoires by phage display technology to generate rabbit monoclonal antibodies (mAbs) with nanomolar affinity to epitopes that are specific for NgR1 and NgR2, respectively, but at the same time conserved between mouse, rat, and human orthologs. Employing phage display vector pC3C, a newly designed phagemid optimized for the generation and selection of Fab libraries with human constant domains, rabbit mAbs were selected from chimeric rabbit/human Fab libraries, characterized in terms of specificity, affinity, and amino acid sequence, and finally converted to chimeric rabbit/human IgG. Using immunofluorescence microscopy and immunoprecipitation, we demonstrate strong and specific recognition of cell surface bound Nogo-66 receptor family members by chimeric rabbit/human IgG. The rabbit mAbs reported here together with their amino acid sequences constitute a defined panel of species cross-reactive reagents in infinite supply which will aid investigations toward a functional role of the Nogo-66 receptor family in and beyond the CNS. JF - Journal of Immunological Methods AU - Hofer, T AU - Tangkeangsirisin, W AU - Kennedy, M G AU - Mage, R G AU - Raiker, S J AU - Venkatesh, K AU - Lee, H AU - Giger, R J AU - Rader, C AD - Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892-1203, USA, raderc@mail.nih.gov Y1 - 2007/01/10/ PY - 2007 DA - 2007 Jan 10 SP - 75 EP - 87 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 318 IS - 1-2 SN - 0022-1759, 0022-1759 KW - Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Central nervous system KW - Cell surface KW - Cross-reactivity KW - Axon sprouting KW - Injuries KW - Nogo protein KW - Receptor mechanisms KW - Monoclonal antibodies KW - Phage display KW - Immunoprecipitation KW - Immunofluorescence KW - Antibodies KW - Neurons KW - Microscopy KW - Immunoglobulin G KW - Axonogenesis KW - Fab KW - Epitopes KW - Amino acid sequence KW - N 14815:Nucleotide Sequence KW - F 06900:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19850283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=Chimeric+rabbit%2Fhuman+Fab+and+IgG+specific+for+members+of+the+Nogo-66+receptor+family+selected+for+species+cross-reactivity+with+an+improved+phage+display+vector&rft.au=Hofer%2C+T%3BTangkeangsirisin%2C+W%3BKennedy%2C+M+G%3BMage%2C+R+G%3BRaiker%2C+S+J%3BVenkatesh%2C+K%3BLee%2C+H%3BGiger%2C+R+J%3BRader%2C+C&rft.aulast=Hofer&rft.aufirst=T&rft.date=2007-01-10&rft.volume=318&rft.issue=1-2&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2006.10.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell surface; Central nervous system; Axon sprouting; Cross-reactivity; Receptor mechanisms; Nogo protein; Injuries; Monoclonal antibodies; Phage display; Immunoprecipitation; Immunofluorescence; Antibodies; Neurons; Microscopy; Immunoglobulin G; Axonogenesis; Fab; Epitopes; Amino acid sequence DO - http://dx.doi.org/10.1016/j.jim.2006.10.007 ER -