TY - JOUR T1 - Nonpsychoactive Cannabidiol Prevents Prion Accumulation and Protects Neurons against Prion Toxicity AN - 20699493; 7615300 AB - Prion diseases are transmissible neurodegenerative disorders characterized by the accumulation in the CNS of the protease-resistant prion protein (PrPres), a structurally misfolded isoform of its physiological counterpart PrPsen. Both neuropathogenesis and prion infectivity are related to PrPres formation. Here, we report that the nonpsychoactive cannabis constituent cannabidiol (CBD) inhibited PrPres accumulation in both mouse and sheep scrapie-infected cells, whereas other structurally related cannabinoid analogs were either weak inhibitors or noninhibitory. Moreover, after intraperitoneal infection with murine scrapie, peripheral injection of CBD limited cerebral accumulation of PrPres and significantly increased the survival time of infected mice. Mechanistically, CBD did not appear to inhibit PrPres accumulation via direct interactions with PrP, destabilization of PrPres aggregates, or alteration of the expression level or subcellular localization of PrPsen. However, CBD did inhibit the neurotoxic effects of PrPres and affected PrPres-induced microglial cell migration in a concentration-dependent manner. Our results suggest that CBD may protect neurons against the multiple molecular and cellular factors involved in the different steps of the neurodegenerative process, which takes place during prion infection. When combined with its ability to target the brain and its lack of toxic side effects, CBD may represent a promising new anti-prion drug. JF - Journal of Neuroscience AU - Dirikoc, Sevda AU - Priola, Suzette A AU - Marella, Mathieu AU - Zsuerger, Nicole AU - Chabry, Joelle AD - Institut de Pharmacologie Moleculaire et Cellulaire, Unite Mixte de Recherche 6097, Centre National de la Recherche Scientifique, 06560 Valbonne, France, Laboratory of Persistent Viral Diseases, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, and Scripps Research Institute, La Jolla, California 92037 Y1 - 2007/09/05/ PY - 2007 DA - 2007 Sep 05 SP - 9537 EP - 9544 PB - Society for Neuroscience, 11 Dupont Circle, N.W. Suite 500 Washington DC 20036 USA, [mailto:info@sfn.org], [URL:http://apu.sfn.org/] VL - 27 IS - 36 SN - 0270-6474, 0270-6474 KW - Toxicology Abstracts; Virology & AIDS Abstracts; CSA Neurosciences Abstracts KW - Central nervous system KW - Neuropathogenesis KW - Brain KW - Scrapie KW - Toxicity KW - Infection KW - Drug abuse KW - Neurodegenerative diseases KW - Infectivity KW - Nervous system KW - Cannabinoids KW - Neurons KW - Neurotoxicity KW - Prion protein KW - Cannabis KW - Cell migration KW - Microglial cells KW - Side effects KW - X 24380:Social Poisons & Drug Abuse KW - N3 11028:Neuropharmacology & toxicology KW - V 22380:Prions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20699493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=Nonpsychoactive+Cannabidiol+Prevents+Prion+Accumulation+and+Protects+Neurons+against+Prion+Toxicity&rft.au=Dirikoc%2C+Sevda%3BPriola%2C+Suzette+A%3BMarella%2C+Mathieu%3BZsuerger%2C+Nicole%3BChabry%2C+Joelle&rft.aulast=Dirikoc&rft.aufirst=Sevda&rft.date=2007-09-05&rft.volume=27&rft.issue=36&rft.spage=9537&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Central nervous system; Brain; Neuropathogenesis; Toxicity; Scrapie; Drug abuse; Infection; Neurodegenerative diseases; Nervous system; Infectivity; Cannabinoids; Neurons; Neurotoxicity; Cannabis; Prion protein; Cell migration; Microglial cells; Side effects ER - TY - JOUR T1 - Short-term and long-term effects of postnatal exposure to an adult male in C57BL/6J mice. AN - 68106178; 17482287 AB - Rodent models provide a valuable approach to elucidating the pathophysiological mechanisms underlying the deleterious effects of childhood trauma and stress. Neonatal rats and mice emit ultrasonic vocalizations (USVs) when separated from the dam and litter. USVs are suppressed in rat pups by exposure to the putatively infanticidal threat of an adult male. In the present study, C57BL/6J mouse pups were exposed to an anaesthetized (non-sire) adult C57BL/6J male for 3-min/day from postnatal days 2-14, and subsequently tested for anxiety-related behaviors (using the novel open field, elevated plus-maze, light/dark exploration tests) and depression-related behavior (using the forced swim test) at 11 weeks of age. In a separate cohort, hypothalamic-pituitary-adrenal-axis activation was measured via plasma corticosterone levels following either a single male-exposure or separation episode. Results showed that pups exposed to an adult male emitted significantly fewer USVs than separation-only counterparts. Corticosterone levels were significantly lower following single exposure to the adult male than separation alone. Repeated neonatal male-exposure did not lead to significant alterations in anxiety- or depression-related behaviors in adulthood. Taken together, present data suggest that the form of adult male-exposure employed did not act as a significant stressor, at least in this mouse strain. Further studies will be needed to determine whether alternative mouse strains, exposure protocols or adult behavioral assays will produce a different pattern of short-term and long-term effects. JF - Behavioural brain research AU - Hefner, Kathryn AU - Cameron, Heather A AU - Karlsson, Rose-Marie AU - Holmes, Andrew AD - Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD 20852-9411, USA. Y1 - 2007/09/04/ PY - 2007 DA - 2007 Sep 04 SP - 344 EP - 348 VL - 182 IS - 2 SN - 0166-4328, 0166-4328 KW - Analgesics KW - 0 KW - Corticosterone KW - W980KJ009P KW - Index Medicus KW - Animals KW - Maze Learning -- drug effects KW - Analysis of Variance KW - Age Factors KW - Maze Learning -- physiology KW - Corticosterone -- blood KW - Mice KW - Dose-Response Relationship, Radiation KW - Acoustic Stimulation -- methods KW - Time Factors KW - Male KW - Animals, Newborn -- physiology KW - Vocalization, Animal -- drug effects KW - Behavior, Animal -- drug effects KW - Vocalization, Animal -- physiology KW - Ultrasonics KW - Mice, Inbred C57BL -- physiology KW - Analgesics -- pharmacology KW - Behavior, Animal -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68106178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+brain+research&rft.atitle=Short-term+and+long-term+effects+of+postnatal+exposure+to+an+adult+male+in+C57BL%2F6J+mice.&rft.au=Hefner%2C+Kathryn%3BCameron%2C+Heather+A%3BKarlsson%2C+Rose-Marie%3BHolmes%2C+Andrew&rft.aulast=Hefner&rft.aufirst=Kathryn&rft.date=2007-09-04&rft.volume=182&rft.issue=2&rft.spage=344&rft.isbn=&rft.btitle=&rft.title=Behavioural+brain+research&rft.issn=01664328&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-26 N1 - Date created - 2007-07-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of the nonreducing end of Shigella dysenteriae type 1 O-specific oligosaccharides on their immunogenicity as conjugates in mice AN - 20300772; 7616672 AB - Endemic and epidemic shigellosis, an acute invasive disease of the lower intestines, afflicts millions of people worldwide with an estimated one million fatalities per annum at a low infectious dose. Our approach to vaccine development against Shigella is based on the hypothesis that serum IgG antibodies to the O-specific polysaccharide (O-SP) domains of the LPS of these organisms confer protection to infection. The synthetic oligosaccharides corresponding to the tetrasaccharide repeating unit of the O-SP of Shigella dysenteriae type 1 covalently linked to human serum albumin elicited O-SP-specific IgG in mice. The antibody levels were a function of both the saccharide chain length and their loading on the protein. These synthetic saccharide conjugates elicited significantly higher levels of IgG anti O-SP than conjugates prepared with the O-SP from the bacteria. Here, we evaluated the influence of the nonreducing terminal monosaccharide on the serum antibody response. To this end, we prepared synthetic oligosaccharides comprising hexa- to tridecasaccharide fragments of the native O-SP, having one of the four monosaccharide residues that constitute the repeating unit at their termini and bound them to BSA by a single-point attachment. The conjugates contained an average of 19 saccharide chains per BSA. The synthetic oligosaccharides inhibited the binding of serum raised against whole bacteria to its LPS to a similar extent but lower than the native O-SP. The highest anti-LPS levels were elicited by conjugates having N-acetylglucosamine (10-mer) or galactose residues (7- and 11-mers) at their nonreducing termini. JF - Proceedings of the National Academy of Sciences, USA AU - Pozsgay, Vince AU - Kubler-Kielb, Joanna AU - Schneerson, Rachel AU - Robbins, John B AD - Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-2423 Y1 - 2007/09/04/ PY - 2007 DA - 2007 Sep 04 SP - 14478 EP - 14482 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 36 SN - 0027-8424, 0027-8424 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Galactose KW - Epidemics KW - oligosaccharides KW - human serum albumin KW - Shigella KW - Antibody response KW - monosaccharides KW - N-Acetylglucosamine KW - Polysaccharides KW - Infection KW - Shigella dysenteriae KW - Immunogenicity KW - Shigellosis KW - Intestine KW - Immunoglobulin G KW - Lipopolysaccharides KW - Vaccines KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20300772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Effect+of+the+nonreducing+end+of+Shigella+dysenteriae+type+1+O-specific+oligosaccharides+on+their+immunogenicity+as+conjugates+in+mice&rft.au=Pozsgay%2C+Vince%3BKubler-Kielb%2C+Joanna%3BSchneerson%2C+Rachel%3BRobbins%2C+John+B&rft.aulast=Pozsgay&rft.aufirst=Vince&rft.date=2007-09-04&rft.volume=104&rft.issue=36&rft.spage=14478&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Galactose; oligosaccharides; Epidemics; human serum albumin; N-Acetylglucosamine; monosaccharides; Antibody response; Infection; Polysaccharides; Shigellosis; Immunogenicity; Immunoglobulin G; Intestine; Lipopolysaccharides; Vaccines; Shigella; Shigella dysenteriae ER - TY - JOUR T1 - Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade AN - 20078297; 7558391 AB - Systemic onset juvenile idiopathic arthritis (SoJIA) represents up to 20% of juvenile idiopathic arthritis. We recently reported that interleukin (IL) 1 is an important mediator of this disease and that IL-1 blockade induces clinical remission. However, lack of specificity of the initial systemic manifestations leads to delays in diagnosis and initiation of therapy. To develop a specific diagnostic test, we analyzed leukocyte gene expression profiles of 44 pediatric SoJIA patients, 94 pediatric patients with acute viral and bacterial infections, 38 pediatric patients with systemic lupus erythematosus (SLE), 6 patients with PAPA syndrome, and 39 healthy children. Statistical group comparison and class prediction identified genes differentially expressed in SoJIA patients compared with healthy children. These genes, however, were also changed in patients with acute infections and SLE. An analysis of significance across all diagnostic groups identified 88 SoJIA-specific genes, 12 of which accurately classified an independent set of SoJIA patients with systemic disease. Transcripts that changed significantly in patients undergoing IL-1 blockade were also identified. Thus, leukocyte transcriptional signatures can be used to distinguish SoJIA from other febrile illnesses and to assess response to therapy. Availability of early diagnostic markers may allow prompt initiation of therapy and prevention of disabilities. JF - Journal of Experimental Medicine AU - Allantaz, Florence AU - Chaussabel, Damien AU - Stichweh, Dorothee AU - Bennett, Lynda AU - Allman, Windy AU - Mejias, Asuncion AU - Ardura, Monica AU - Chung, Wendy AU - Wise, Carol AU - Palucka, Karolina AU - Ramilo, Octavio AU - Punaro, Marilynn AU - Banchereau, Jacques AU - Pascual, Virginia AD - Baylor National Institute of Allergy and Infectious Diseases Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX 75204. Baylor Institute for Immunology Research, Dallas, TX 75204. Division of Pediatric Infectious Diseases and Division of Pediatric Rheumatology, UT Southwestern Medical Center, Dallas, TX 75390. Texas Scottish Rite Hospital, Dallas, TX 75219 Y1 - 2007/09/03/ PY - 2007 DA - 2007 Sep 03 SP - 2131 EP - 2144 PB - Rockefeller University Press, 1114 First Avenue New York NY 10021-8325 USA, [mailto:Bruce.Lyons@rockefeller.edu], [URL:http://www.rockefeller.edu/rupress] VL - 204 IS - 9 SN - 0022-1007, 0022-1007 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Statistics KW - Pediatrics KW - Leukocytes KW - Interleukin 1 KW - Transcription KW - Remission KW - Children KW - Infection KW - DNA microarrays KW - Gene expression KW - Blood KW - Arthritis KW - Systemic lupus erythematosus KW - J 02400:Human Diseases KW - F 06930:Autoimmunity KW - W 30900:Methods KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20078297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Medicine&rft.atitle=Blood+leukocyte+microarrays+to+diagnose+systemic+onset+juvenile+idiopathic+arthritis+and+follow+the+response+to+IL-1+blockade&rft.au=Allantaz%2C+Florence%3BChaussabel%2C+Damien%3BStichweh%2C+Dorothee%3BBennett%2C+Lynda%3BAllman%2C+Windy%3BMejias%2C+Asuncion%3BArdura%2C+Monica%3BChung%2C+Wendy%3BWise%2C+Carol%3BPalucka%2C+Karolina%3BRamilo%2C+Octavio%3BPunaro%2C+Marilynn%3BBanchereau%2C+Jacques%3BPascual%2C+Virginia&rft.aulast=Allantaz&rft.aufirst=Florence&rft.date=2007-09-03&rft.volume=204&rft.issue=9&rft.spage=2131&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Medicine&rft.issn=00221007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Statistics; Pediatrics; Interleukin 1; Leukocytes; Remission; Transcription; Infection; Children; DNA microarrays; Gene expression; Blood; Arthritis; Systemic lupus erythematosus ER - TY - CPAPER T1 - Carcinosarcoma of the Lung with Soft Tissues Metastases. A Case Report T2 - 12th World Conference on Lung Cancer AN - 39543436; 4651323 JF - 12th World Conference on Lung Cancer AU - Parra, Luis Dominguez Y1 - 2007/09/02/ PY - 2007 DA - 2007 Sep 02 KW - Lung KW - Soft tissues KW - Case reports KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39543436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+World+Conference+on+Lung+Cancer&rft.atitle=Carcinosarcoma+of+the+Lung+with+Soft+Tissues+Metastases.+A+Case+Report&rft.au=Parra%2C+Luis+Dominguez&rft.aulast=Parra&rft.aufirst=Luis&rft.date=2007-09-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.2007worldlungcancer.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevalence and Pattern of Lymph Node Metastasis in Malignant Pleural Mesothelioma T2 - 12th World Conference on Lung Cancer AN - 39474904; 4651313 JF - 12th World Conference on Lung Cancer AU - Rahman, Mohamed Abdel Y1 - 2007/09/02/ PY - 2007 DA - 2007 Sep 02 KW - Lymph nodes KW - Mesothelioma KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39474904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+World+Conference+on+Lung+Cancer&rft.atitle=Prevalence+and+Pattern+of+Lymph+Node+Metastasis+in+Malignant+Pleural+Mesothelioma&rft.au=Rahman%2C+Mohamed+Abdel&rft.aulast=Rahman&rft.aufirst=Mohamed&rft.date=2007-09-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.2007worldlungcancer.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Number of Surgically Removed Mediastinal Lymph-Nodes (SRMLNs) as Prognostic Factor for Survival in Resected Early Stage Non-Small-Cell Lung Cancer (NSCLC): A Retrospective Analysis of a Mono-Institutional Series T2 - 12th World Conference on Lung Cancer AN - 39445226; 4652024 JF - 12th World Conference on Lung Cancer AU - Alessandrini, Gabriele Y1 - 2007/09/02/ PY - 2007 DA - 2007 Sep 02 KW - Lung cancer KW - Survival KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39445226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+World+Conference+on+Lung+Cancer&rft.atitle=Number+of+Surgically+Removed+Mediastinal+Lymph-Nodes+%28SRMLNs%29+as+Prognostic+Factor+for+Survival+in+Resected+Early+Stage+Non-Small-Cell+Lung+Cancer+%28NSCLC%29%3A+A+Retrospective+Analysis+of+a+Mono-Institutional+Series&rft.au=Alessandrini%2C+Gabriele&rft.aulast=Alessandrini&rft.aufirst=Gabriele&rft.date=2007-09-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.2007worldlungcancer.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Promotion of Squamous Differentiation and Tumorigenesis in Mouse Lung Expressing Human Keratin 14 T2 - 12th World Conference on Lung Cancer AN - 39430599; 4651120 JF - 12th World Conference on Lung Cancer AU - Linnoila, Ilona Y1 - 2007/09/02/ PY - 2007 DA - 2007 Sep 02 KW - Lung KW - Tumorigenesis KW - Differentiation KW - Keratin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39430599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+World+Conference+on+Lung+Cancer&rft.atitle=Promotion+of+Squamous+Differentiation+and+Tumorigenesis+in+Mouse+Lung+Expressing+Human+Keratin+14&rft.au=Linnoila%2C+Ilona&rft.aulast=Linnoila&rft.aufirst=Ilona&rft.date=2007-09-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.2007worldlungcancer.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of SV-40 as a Biological Prognostic Factor in Egyptian Patients with Malignant Pleural Mesothelioma T2 - 12th World Conference on Lung Cancer AN - 39427415; 4651314 JF - 12th World Conference on Lung Cancer AU - Bahnassy, Abeer Y1 - 2007/09/02/ PY - 2007 DA - 2007 Sep 02 KW - Mesothelioma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39427415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+World+Conference+on+Lung+Cancer&rft.atitle=Evaluation+of+SV-40+as+a+Biological+Prognostic+Factor+in+Egyptian+Patients+with+Malignant+Pleural+Mesothelioma&rft.au=Bahnassy%2C+Abeer&rft.aulast=Bahnassy&rft.aufirst=Abeer&rft.date=2007-09-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.2007worldlungcancer.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pulmonary Metastases from a Giant Tumor Cell of Bone. A Case Report T2 - 12th World Conference on Lung Cancer AN - 39413614; 4651324 JF - 12th World Conference on Lung Cancer AU - Dominguez-Parra, Luis Y1 - 2007/09/02/ PY - 2007 DA - 2007 Sep 02 KW - Bone KW - Tumor cells KW - Lung KW - Case reports KW - Metastases KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39413614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+World+Conference+on+Lung+Cancer&rft.atitle=Pulmonary+Metastases+from+a+Giant+Tumor+Cell+of+Bone.+A+Case+Report&rft.au=Dominguez-Parra%2C+Luis&rft.aulast=Dominguez-Parra&rft.aufirst=Luis&rft.date=2007-09-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.2007worldlungcancer.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nuclear and Cytoplasmic Cellular Distribution of Survivin as Survival Predictor in Resected Non-Small-Cell Lung Cancer. T2 - 12th World Conference on Lung Cancer AN - 39373853; 4651369 JF - 12th World Conference on Lung Cancer AU - Bria, Emilio Y1 - 2007/09/02/ PY - 2007 DA - 2007 Sep 02 KW - Lung cancer KW - Survival KW - Survivin KW - Cell survival KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39373853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+World+Conference+on+Lung+Cancer&rft.atitle=Nuclear+and+Cytoplasmic+Cellular+Distribution+of+Survivin+as+Survival+Predictor+in+Resected+Non-Small-Cell+Lung+Cancer.&rft.au=Bria%2C+Emilio&rft.aulast=Bria&rft.aufirst=Emilio&rft.date=2007-09-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.2007worldlungcancer.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Brain temperature fluctuations during physiological and pathological conditions AN - 883013301; 14082004 AB - This review discusses brain temperature as a physiological parameter, which is determined primarily by neural metabolism, regulated by cerebral blood flow, and affected by various environmental factors and drugs. First, we consider normal fluctuations in brain temperature that are induced by salient environmental stimuli and occur during motivated behavior at stable normothermic conditions. Second, we analyze changes in brain temperature induced by various drugs that affect brain and body metabolism and heat dissipation. Third, we consider how these physiological and drug-induced changes in brain temperature are modulated by environmental conditions that diminish heat dissipation. Our focus is psychomotor stimulant drugs and brain hyperthermia as a factor inducing or potentiating neurotoxicity. Finally, we discuss how brain temperature is regulated, what changes in brain temperature reflect, and how these changes may affect neural functions under normal and pathological conditions. Although most discussed data were obtained in animals and several important aspects of brain temperature regulation in humans remain unknown, our focus is on the relevance of these data for human physiology and pathology. JF - European Journal of Applied Physiology AU - Kiyatkin, Eugene A AD - Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, DHHS, 333 Cassell Drive, Baltimore, MD, 21224, USA, ekiyatki@intra.nida.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 3 EP - 17 PB - Springer-Verlag, P.O. Box 2485 Secaucus NJ 07096-2485 USA VL - 101 IS - 1 SN - 1439-6319, 1439-6319 KW - Physical Education Index; Toxicology Abstracts; CSA Neurosciences Abstracts KW - Hyperthermia KW - Body temperature KW - Physiology KW - Environmental factors KW - Blood flow KW - Environmental effects KW - Stimuli KW - Drugs KW - Temperature effects KW - Data processing KW - Motivation KW - Brain KW - Psychomotor stimulants KW - Heat KW - Analysis KW - Neurotoxicity KW - Environmental conditions KW - Cerebral blood flow KW - Metabolism KW - X 24310:Pharmaceuticals KW - N3 11028:Neuropharmacology & toxicology KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883013301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Applied+Physiology&rft.atitle=Brain+temperature+fluctuations+during+physiological+and+pathological+conditions&rft.au=Kiyatkin%2C+Eugene+A&rft.aulast=Kiyatkin&rft.aufirst=Eugene&rft.date=2007-09-01&rft.volume=101&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Applied+Physiology&rft.issn=14396319&rft_id=info:doi/10.1007%2Fs00421-007-0450-7 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Hyperthermia; Blood flow; Heat; Analysis; Physiology; Brain; Stimuli; Drugs; Metabolism; Temperature effects; Data processing; Body temperature; Motivation; Psychomotor stimulants; Environmental factors; Neurotoxicity; Environmental effects; Environmental conditions; Cerebral blood flow DO - http://dx.doi.org/10.1007/s00421-007-0450-7 ER - TY - JOUR T1 - Nerve growth factor potentiates p53 DNA binding but inhibits nitric oxide-induced apoptosis in neuronal PC12 cells. AN - 70768386; 17592775 AB - NGF is recognized for its role in neuronal differentiation and maintenance. Differentiation of PC12 cells by NGF involves p53, a transcription factor that controls growth arrest and apoptosis. We investigated NGF influence over p53 activity during NO-induced apoptosis by sodium nitroprusside in differentiated and mitotic PC12 cells. NGF-differentiation produced increased p53 levels, nuclear localization and sequence-specific DNA binding. Apoptosis in mitotic cells also produced these events but the accompanying activation of caspases 1-10 and mitochondrial depolarization were inhibited during NGF differentiation and could be reversed in p53-silenced cells. Transcriptional regulation of PUMA and survivin expression were not inhibited by NGF, although NO-induced mitochondrial depolarization was dependent upon de novo gene transcription and only occurred in mitotic cells. We conclude that NGF mediates prosurvival signaling by increasing factors such as Bcl-2 and p21(Waf1/Cip1) without altering p53 transcriptional activity to inhibit mitochondrial depolarization, caspase activation and apoptosis. JF - Neurochemical research AU - Brynczka, Christopher AU - Merrick, Bruce Alex AD - National Center for Toxicogenomics, National Institute of Environmental Health Sciences, National Institutes of Health, P.O. Box 12233, Research Triangle Park, NC 27709, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 1573 EP - 1585 VL - 32 IS - 9 SN - 0364-3190, 0364-3190 KW - Tumor Suppressor Protein p53 KW - 0 KW - Nitroprusside KW - 169D1260KM KW - Nitric Oxide KW - 31C4KY9ESH KW - DNA KW - 9007-49-2 KW - Nerve Growth Factor KW - 9061-61-4 KW - Caspases KW - EC 3.4.22.- KW - Index Medicus KW - Rats KW - Signal Transduction -- physiology KW - Animals KW - Membrane Potential, Mitochondrial -- drug effects KW - Cell Survival -- drug effects KW - Enzyme Activation KW - Nitric Oxide -- pharmacology KW - Nitroprusside -- pharmacology KW - Drug Synergism KW - Cell Differentiation -- drug effects KW - Caspases -- metabolism KW - PC12 Cells KW - DNA -- metabolism KW - Apoptosis -- drug effects KW - Nerve Growth Factor -- physiology KW - Tumor Suppressor Protein p53 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70768386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemical+research&rft.atitle=Nerve+growth+factor+potentiates+p53+DNA+binding+but+inhibits+nitric+oxide-induced+apoptosis+in+neuronal+PC12+cells.&rft.au=Simmons%2C+W+Kyle%3BMatlis%2C+Sean%3BBellgowan%2C+Patrick+S.F.%3BBodurka%2C+Jerzy%3BBarsalou%2C+Lawrence+W%3BMartin%2C+Alex&rft.aulast=Simmons&rft.aufirst=W&rft.date=2007-05-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-09 N1 - Date created - 2007-07-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2002 Mar 15;62(6):1648-53 [11912135] Atherosclerosis. 2002 May;162(1):93-101 [11947902] Oncogene. 2002 Apr 18;21(17):2613-22 [11965534] Ann N Y Acad Sci. 2002 May;962:318-31 [12076984] Nat Rev Cancer. 2002 Aug;2(8):594-604 [12154352] Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10364-9 [12136132] J Biol Chem. 2002 Oct 4;277(40):37949-54 [12151395] J Pharmacol Exp Ther. 2003 Jan;304(1):1-7 [12490568] Neurobiol Dis. 2003 Feb;12(1):35-45 [12609487] J Biol Chem. 2003 Apr 18;278(16):13898-904 [12578834] Ann Med. 2003;35(1):21-7 [12693609] Biochem Biophys Res Commun. 2003 Jun 6;305(3):776-83 [12763060] J Neurosci. 1996 Apr 1;16(7):2325-34 [8601812] J Cell Sci. 1996 Feb;109 ( Pt 2):289-300 [8838652] Oncogene. 2003 May 15;22(19):2857-68 [12771937] Exp Neurol. 2003 Jun;181(2):115-29 [12781986] Chem Res Toxicol. 2003 Aug;16(8):1004-13 [12924928] J Neurochem. 2003 Sep;86(6):1553-63 [12950464] Neurosci Lett. 2004 Jan 16;354(3):213-6 [14700734] Science. 2004 Feb 13;303(5660):1010-4 [14963330] J Neurochem. 2004 May;89(4):812-21 [15140181] J Biol Chem. 2004 Jul 23;279(30):30983-93 [15133027] Proc Natl Acad Sci U S A. 1976 Jul;73(7):2424-8 [1065897] Nature. 1990 Oct 25;347(6295):768-70 [1700301] Cell. 1991 Apr 5;65(1):189-97 [1849459] Cancer Res. 1994 Mar 1;54(5):1169-74 [8118801] Nature. 1996 Nov 28;384(6607):368-72 [8934524] Neurochem Int. 1996 Nov;29(5):461-7 [8939456] Biochem Biophys Res Commun. 1996 Dec 13;229(2):653-7 [8954953] J Neurosci Res. 1997 Aug 15;49(4):461-74 [9285522] Cell. 1997 Oct 31;91(3):325-34 [9363941] Biochem Biophys Res Commun. 1997 Nov 17;240(2):419-24 [9388494] Oncogene. 1998 Feb 19;16(7):825-32 [9484773] Eur J Biochem. 1998 Jan 15;251(1-2):195-200 [9492284] J Neurosci. 1998 Apr 15;18(8):2933-43 [9526010] Ann Neurol. 1998 Sep;44(3 Suppl 1):S115-20 [9749582] Brain Res Mol Brain Res. 1999 Feb 5;64(2):165-78 [9931481] Biochim Biophys Acta. 1999 Aug 5;1428(2-3):357-71 [10434055] Neurosci Lett. 1999 Jul 23;270(1):45-8 [10454142] Mol Cell Neurosci. 2004 Nov;27(3):322-31 [15519246] Mol Cells. 2004 Dec 31;18(3):353-9 [15650333] Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1339-44 [15677324] Toxicology. 2005 Mar 15;208(2):177-92 [15691583] Biochem Biophys Res Commun. 2005 Jun 10;331(3):851-8 [15865941] Curr Alzheimer Res. 2005 Apr;2(2):167-9 [15974914] Cell Death Differ. 2005 Aug;12(8):1066-77 [15877105] Carcinogenesis. 2005 Aug;26(8):1317-22 [15888490] Free Radic Biol Med. 2005 Oct 1;39(7):890-9 [16140209] Cell Cycle. 2005 Sep;4(9):1286-93 [16082214] Biochem Biophys Res Commun. 2006 Apr 14;342(3):984-90 [16598857] Oncogene. 2006 Apr 6;25(15):2203-12 [16288207] Brain Res. 2006 Apr 21;1084(1):1-15 [16564033] EMBO J. 2006 May 17;25(10):2083-95 [16642037] Bioessays. 2006 Jun;28(6):583-94 [16700063] J Neurosci Res. 2006 Jul;84(1):78-96 [16625660] Cell Death Differ. 2006 Aug;13(8):1396-402 [16710362] EMBO J. 2006 Sep 6;25(17):4084-96 [16946709] Brain Res. 2006 Sep 27;1112(1):1-15 [16901471] Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1693-705 [16987022] Cell Death Differ. 2006 Dec;13(12):2118-28 [16729028] J Biol Chem. 2006 Dec 1;281(48):36603-12 [17020887] Cancer Res. 2006 Dec 1;66(23):11254-62 [17145870] Mutat Res. 2007 Jan 3;614(1-2):24-36 [16879837] J Biol Chem. 2000 Mar 24;275(12):8817-24 [10722727] J Biol Chem. 2000 Apr 14;275(15):10761-6 [10753867] Crit Care Med. 2000 Apr;28(4 Suppl):N37-52 [10807315] Arch Neurol. 2000 Jun;57(6):846-51 [10867782] J Neurochem. 2000 Oct;75(4):1455-64 [10987825] J Biol Chem. 2000 Dec 1;275(48):37829-37 [10978315] Exp Cell Res. 2001 Jan 15;262(2):170-9 [11139341] Nat Rev Mol Cell Biol. 2000 Nov;1(2):120-9 [11253364] Blood. 2001 Jul 15;98(2):405-13 [11435310] Annu Rev Neurosci. 2001;24:1217-81 [11520933] Cell Death Differ. 2001 Sep;8(9):909-20 [11526446] J Biol Chem. 2002 Feb 1;277(5):3247-57 [11714700] Science. 2002 Mar 8;295(5561):1901-4 [11884757] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Substitution of oral and intravenous thioguanine for mercaptopurine in a treatment regimen for children with standard risk acute lymphoblastic leukemia: a collaborative Children's Oncology Group/National Cancer Institute pilot trial (CCG-1942). AN - 70763079; 16856155 AB - Although mercaptopurine (MP) is conventionally used to treat childhood acute lymphoblastic leukemia (ALL), thioguanine (TG) is a more potent thiopurine in vitro and, when administered orally to patients, achieves cytotoxic drug concentrations in the cerebrospinal fluid (CSF). We performed a pilot study incorporating oral and 24-hr continuous IV infusion (CIVI) TG in children with newly diagnosed standard-risk ALL. Children with newly diagnosed standard-risk ALL (age 1-10 years, WBC<50 k) were eligible. Multi-agent chemotherapy was patterned after the Children's Cancer Group (CCG) 105 trial, with the addition of CIVI-TG (480 mg/m2) during consolidation, interim maintenance and maintenance, and substitution of oral TG (60 mg/m2/day) for oral MP during maintenance. Fifty-eight patients (31 female), median age 4.3 years, were enrolled. At 8 years, the relapse-free and overall survival probabilities were 83% and 88%. There were no CNS relapses. Six patients (five males) experienced reversible veno-occlusive disease (VOD) while receiving oral TG, and the study was amended to discontinue TG, changing all patients to oral MP. Red cell TG nucleotide concentrations during oral TG averaged 95 ng (570 pmol)/8x10(8) RBC, greater than concentrations reported with oral MP. Although the absence of CNS relapses in this pilot study suggests that TG may contribute to the prevention of CNS recurrences, the development of VOD negatively impacts the risk:benefit ratio of substituting TG for MP. Copyright (c) 2006 Wiley-Liss, Inc. JF - Pediatric blood & cancer AU - Jacobs, Shana S AU - Stork, Linda C AU - Bostrom, Bruce C AU - Hutchinson, Ray AU - Holcenberg, John AU - Reaman, Gregory H AU - Erdmann, Gary AU - Franklin, Janet AU - Neglia, Joseph P AU - Steinberg, Seth M AU - Balis, Frank M AU - Adamson, Peter C AU - Children's Oncology Group AU - National Cancer Institute AD - Children's National Medical Center, Washington, District of Columbia, USA. jacobss@mail.nih.gov ; Children's Oncology Group ; National Cancer Institute Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 250 EP - 255 VL - 49 IS - 3 SN - 1545-5009, 1545-5009 KW - Antimetabolites, Antineoplastic KW - 0 KW - Thioguanine KW - FTK8U1GZNX KW - Index Medicus KW - Administration, Oral KW - Infusions, Intravenous KW - Drug-Related Side Effects and Adverse Reactions KW - Humans KW - Child KW - Pilot Projects KW - Child, Preschool KW - Infant KW - Hepatic Veno-Occlusive Disease -- chemically induced KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Female KW - Male KW - Survival Analysis KW - Antimetabolites, Antineoplastic -- administration & dosage KW - Thioguanine -- administration & dosage KW - Antimetabolites, Antineoplastic -- adverse effects KW - Thioguanine -- adverse effects KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70763079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+blood+%26+cancer&rft.atitle=Substitution+of+oral+and+intravenous+thioguanine+for+mercaptopurine+in+a+treatment+regimen+for+children+with+standard+risk+acute+lymphoblastic+leukemia%3A+a+collaborative+Children%27s+Oncology+Group%2FNational+Cancer+Institute+pilot+trial+%28CCG-1942%29.&rft.au=Jacobs%2C+Shana+S%3BStork%2C+Linda+C%3BBostrom%2C+Bruce+C%3BHutchinson%2C+Ray%3BHolcenberg%2C+John%3BReaman%2C+Gregory+H%3BErdmann%2C+Gary%3BFranklin%2C+Janet%3BNeglia%2C+Joseph+P%3BSteinberg%2C+Seth+M%3BBalis%2C+Frank+M%3BAdamson%2C+Peter+C%3BChildren%27s+Oncology+Group%3BNational+Cancer+Institute&rft.aulast=Jacobs&rft.aufirst=Shana&rft.date=2007-09-01&rft.volume=49&rft.issue=3&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=Pediatric+blood+%26+cancer&rft.issn=15455009&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-18 N1 - Date created - 2007-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Yoga therapy as an add-on treatment in the management of patients with schizophrenia--a randomized controlled trial. AN - 70750281; 17655565 AB - Treatment of schizophrenia has remained unsatisfactory despite the availability of antipsychotics. This study examined the efficacy of yoga therapy (YT) as an add-on treatment to the ongoing antipsychotic treatment. Sixty-one moderately ill schizophrenia patients were randomly assigned to YT (n = 31) and physical exercise therapy (PT; n = 30) for 4 months. They were assessed at baseline and 4 months after the start of intervention, by a rater who was blind to their group status. Forty-one subjects (YT = 21; PT = 20) were available at the end of 4 months for assessment. Subjects in the YT group had significantly less psychopathology than those in the PT group at the end of 4 months. They also had significantly greater social and occupational functioning and quality of life. Both non-pharmacological interventions contribute to reduction in symptoms, with YT having better efficacy. JF - Acta psychiatrica Scandinavica AU - Duraiswamy, G AU - Thirthalli, J AU - Nagendra, H R AU - Gangadhar, B N AD - Department of Psychiatry, National Institute of Mental Health and NeuroSciences, Bangalore 560029, India. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 226 EP - 232 VL - 116 IS - 3 SN - 0001-690X, 0001-690X KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Depression -- therapy KW - Single-Blind Method KW - Combined Modality Therapy KW - Humans KW - Depression -- psychology KW - Adult KW - Follow-Up Studies KW - Exercise -- psychology KW - Male KW - Female KW - Yoga KW - Antipsychotic Agents -- therapeutic use KW - Schizophrenic Psychology KW - Schizophrenia -- therapy KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70750281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+psychiatrica+Scandinavica&rft.atitle=Yoga+therapy+as+an+add-on+treatment+in+the+management+of+patients+with+schizophrenia--a+randomized+controlled+trial.&rft.au=Duraiswamy%2C+G%3BThirthalli%2C+J%3BNagendra%2C+H+R%3BGangadhar%2C+B+N&rft.aulast=Duraiswamy&rft.aufirst=G&rft.date=2007-09-01&rft.volume=116&rft.issue=3&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Acta+psychiatrica+Scandinavica&rft.issn=0001690X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-18 N1 - Date created - 2007-07-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Acta Psychiatr Scand. 2008 May;117(5):397 [18241310] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The combined activation of positive costimulatory signals with modulation of a negative costimulatory signal for the enhancement of vaccine-mediated T-cell responses. AN - 70661828; 17318654 AB - Blockade of CTLA-4 by monoclonal antibodies (mAb) can mediate regression of tumors and increase the efficacy of tumor antigen specific vaccines. Blockade of CTLA-4 has also been shown to significantly increase the avidity of antigen-specific T cells after immunization with live recombinant viral vector based vaccine. Here, we demonstrate a biological synergy between CTLA-4 blockade and active vaccine therapy consisting of recombinant vaccinia and avipox viruses expressing carcinoembryonic antigen (CEA) and three T cell costimulatory molecules to enhance antitumor effects. However, this synergy was very much dependent on the temporal relationship of scheduling of the two agents. We evaluated the strategies in both a foreign antigen model using beta-galactosidase as immunogen, and in a "self" antigen model using CEA as immunogen. For antitumor activity the model used consisted of mice transgenic for human CEA and a murine carcinoma cell line transfected with CEA. The enhanced antitumor activity after vaccine and CTLA-4 blockade did not result in any signs of autoimmunity. These studies form a rational basis for the use of vector-based vaccines with anti-CTLA-4 and demonstrate that both enhancement of positive costimulatory signals and inhibition of negative costimulatory signals can be simultaneously exploited. These studies also underscore the importance of "drug" scheduling in vaccine combination therapies. JF - Cancer immunology, immunotherapy : CII AU - Chakraborty, Mala AU - Schlom, Jeffrey AU - Hodge, James W AD - Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive Room 8B09, Bethesda, MD 20892, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 1471 EP - 1484 VL - 56 IS - 9 SN - 0340-7004, 0340-7004 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, CD KW - Antigens, Differentiation KW - CTLA-4 Antigen KW - CTLA4 protein, human KW - Cancer Vaccines KW - Ctla4 protein, mouse KW - Recombinant Proteins KW - Index Medicus KW - Animals KW - Humans KW - Mice, Inbred C57BL KW - Antigens, CD -- drug effects KW - Mice KW - Cell Line, Tumor KW - Antibody Affinity KW - Recombinant Proteins -- genetics KW - Antigens, Differentiation -- drug effects KW - Female KW - Lymphocyte Activation KW - Vaccinia virus -- genetics KW - Cancer Vaccines -- pharmacology KW - Immunization -- methods KW - Antibodies, Monoclonal -- pharmacology KW - Neoplasms -- therapy KW - Drug Synergism KW - T-Lymphocytes -- immunology KW - Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70661828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+immunology%2C+immunotherapy+%3A+CII&rft.atitle=The+combined+activation+of+positive+costimulatory+signals+with+modulation+of+a+negative+costimulatory+signal+for+the+enhancement+of+vaccine-mediated+T-cell+responses.&rft.au=Chakraborty%2C+Mala%3BSchlom%2C+Jeffrey%3BHodge%2C+James+W&rft.aulast=Chakraborty&rft.aufirst=Mala&rft.date=2007-09-01&rft.volume=56&rft.issue=9&rft.spage=1471&rft.isbn=&rft.btitle=&rft.title=Cancer+immunology%2C+immunotherapy+%3A+CII&rft.issn=03407004&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-06 N1 - Date created - 2007-06-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Obesity, metabolic syndrome, and prostate cancer. AN - 70094090; 18265478 AB - Although obesity has been consistently linked to an increased risk of several malignancies, including cancers of the colon, gallbladder, kidney, and pancreas, its role in prostate cancer etiology remains elusive. Data on the association between obesity and prostate cancer incidence are inconsistent, and in some studies obesity is associated with an increase in risk of high-grade prostate cancer but with a decrease in risk of low-grade tumors. In contrast, obesity has been consistently associated with an increased risk of prostate cancer aggressiveness and mortality. The differential effects of obesity on subtypes of prostate cancer suggest etiologic heterogeneity in these tumors and complex interactions between androgen metabolism and several putative risk factors, including insulin resistance, diabetes, inflammation, and genetic susceptibility, on prostate cancer risk. Data on the role of abdominal obesity, insulin resistance, and metabolic syndrome in prostate cancer etiology are limited. Obesity has been shown to be associated with a state of low-grade chronic inflammation, and insulin resistance and the metabolic syndrome are associated with adverse metabolic profiles and with higher circulating concentrations of inflammation-related markers, including leptin, interleukin-6, and tumor necrosis factor-, many of which have been shown to enhance tumor growth. Thus, whether obesity and metabolic syndrome modulate the risk of prostate cancer through chronic inflammation needs to be investigated further. Given that the prevalence of obesity and metabolic syndrome is increasing worldwide and that the world population is aging, the roles of obesity and metabolic syndrome in prostate carcinogenesis warrant further clarification. JF - The American journal of clinical nutrition AU - Hsing, Ann W AU - Sakoda, Lori C AU - Chua, Streamson AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852-7234, USA. hsinga@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - s843 EP - s857 VL - 86 IS - 3 SN - 0002-9165, 0002-9165 KW - Leptin KW - 0 KW - Somatomedins KW - Abridged Index Medicus KW - Index Medicus KW - Risk Factors KW - Humans KW - Somatomedins -- physiology KW - Inflammation -- metabolism KW - Body Mass Index KW - Leptin -- metabolism KW - Abdominal Fat -- metabolism KW - Somatomedins -- metabolism KW - Male KW - Inflammation -- complications KW - Prostatic Neoplasms -- etiology KW - Prostatic Neoplasms -- mortality KW - Prostatic Neoplasms -- epidemiology KW - Metabolic Syndrome X -- epidemiology KW - Obesity -- epidemiology KW - Obesity -- complications KW - Metabolic Syndrome X -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70094090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.atitle=Obesity%2C+metabolic+syndrome%2C+and+prostate+cancer.&rft.au=Hsing%2C+Ann+W%3BSakoda%2C+Lori+C%3BChua%2C+Streamson&rft.aulast=Hsing&rft.aufirst=Ann&rft.date=2007-09-01&rft.volume=86&rft.issue=3&rft.spage=s843&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+clinical+nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-07 N1 - Date created - 2008-02-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The clinical response on bone metastasis from breast and lung cancer during treatment with zoledronic acid is inversely correlated to skeletal related events (SRE). AN - 68475509; 17987788 AB - Current management of bone metastases involves a multimodal approach. Aminobisphosphonates (BPs) are a valid weapon in the treatment of skeletal localization of tumour disease. Patients with bone metastases from breast and lung cancer were enrolled in order to evaluate the impact of the addition of bisphosphonates therapy to standard treatments in terms of (i) pain control, (ii) quality of life (QoL) and (iii) toxicity and to evaluate (iv) any relations between clinical activity and the occurrence of SREs. A total of 60 patients were included in the study. Median age was 76 years (range 40-83). The majority of patients were treated with chemotherapy or hormonal therapy. All patients received zoledronic acid (ZOL) (4 mg) every 3-4 weeks for at least 3 cycles. No significant improvement in Performance Status of patients after 12 cycles of ZOL (p = 0.1672) was recorded. A statistically significant early and long-lasting amelioration of both pain, narcotic scores and QoL was found. Twenty-one patients (48%) experienced at least one SRE during the study. The most common SRE was radiation to bone (30% of patients). An inverse correlation between bone tumour response and SREs was also found (p = 0.019). ZOL addition induces a clinical benefit and improves QoL of patients with bone metastases. Moreover, the occurrence of bone clinical response is related to a reduced risk of SREs. JF - Journal of experimental & clinical cancer research : CR AU - Facchini, G AU - Caraglia, M AU - Santini, D AU - Nasti, G AU - Ottaiano, A AU - Striano, S AU - Maiolino, P AU - Ruberto, M AU - Fiore, F AU - Tonini, G AU - Budillon, A AU - Iaffaioli, R V AU - Zeppetella, G L AD - Medical Oncology Division B, National Cancer Institute, Naples, Italy. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 307 EP - 312 VL - 26 IS - 3 SN - 0392-9078, 0392-9078 KW - Bone Density Conservation Agents KW - 0 KW - Diphosphonates KW - Imidazoles KW - zoledronic acid KW - 6XC1PAD3KF KW - Index Medicus KW - Musculoskeletal System -- drug effects KW - Aged, 80 and over KW - Humans KW - Adult KW - Quality of Life KW - Aged KW - Middle Aged KW - Male KW - Female KW - Breast Neoplasms -- drug therapy KW - Diphosphonates -- therapeutic use KW - Diphosphonates -- adverse effects KW - Bone Density Conservation Agents -- therapeutic use KW - Imidazoles -- administration & dosage KW - Lung Neoplasms -- drug therapy KW - Bone Density Conservation Agents -- adverse effects KW - Breast Neoplasms -- pathology KW - Diphosphonates -- administration & dosage KW - Imidazoles -- therapeutic use KW - Bone Density Conservation Agents -- administration & dosage KW - Bone Neoplasms -- secondary KW - Imidazoles -- adverse effects KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68475509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+experimental+%26+clinical+cancer+research+%3A+CR&rft.atitle=The+clinical+response+on+bone+metastasis+from+breast+and+lung+cancer+during+treatment+with+zoledronic+acid+is+inversely+correlated+to+skeletal+related+events+%28SRE%29.&rft.au=Facchini%2C+G%3BCaraglia%2C+M%3BSantini%2C+D%3BNasti%2C+G%3BOttaiano%2C+A%3BStriano%2C+S%3BMaiolino%2C+P%3BRuberto%2C+M%3BFiore%2C+F%3BTonini%2C+G%3BBudillon%2C+A%3BIaffaioli%2C+R+V%3BZeppetella%2C+G+L&rft.aulast=Facchini&rft.aufirst=G&rft.date=2007-09-01&rft.volume=26&rft.issue=3&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Journal+of+experimental+%26+clinical+cancer+research+%3A+CR&rft.issn=03929078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-26 N1 - Date created - 2007-11-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - DLC-1:a Rho GTPase-activating protein and tumour suppressor. AN - 68470991; 17979893 AB - The deleted in liver cancer 1 (DLC-1) gene encodes a GTPase activating protein that acts as a negative regulator of the Rho family of small GTPases. Rho proteins transduce signals that influence cell morphology and physiology, and their aberrant up-regulation is a key factor in the neoplastic process, including metastasis. Since its discovery, compelling evidence has accumulated that demonstrates a role for DLC-1 as a bona fide tumour suppressor gene in different types of human cancer. Loss of DLC-1 expression mediated by genetic and epigenetic mechanisms has been associated with the development of many human cancers, and restoration of DLC-1 expression inhibited the growth of tumour cells in vivo and in vitro. Two closely related genes, DLC-2 and DLC-3, may also be tumour suppressors. This review presents the current status of progress in understanding the biological functions of DLC-1 and its relatives and their roles in neoplasia. JF - Journal of cellular and molecular medicine AU - Durkin, Marian E AU - Yuan, Bao-Zhu AU - Zhou, Xiaoling AU - Zimonjic, Drazen B AU - Lowy, Douglas R AU - Thorgeirsson, Snorri S AU - Popescu, Nicholas C AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. PY - 2007 SP - 1185 EP - 1207 VL - 11 IS - 5 SN - 1582-1838, 1582-1838 KW - GTPase-Activating Proteins KW - 0 KW - Tumor Suppressor Proteins KW - rho GTPase-activating protein KW - Index Medicus KW - Animals KW - Neoplasms -- pathology KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Protein Structure, Tertiary KW - Neoplasms -- metabolism KW - GTPase-Activating Proteins -- genetics KW - GTPase-Activating Proteins -- chemistry KW - GTPase-Activating Proteins -- metabolism KW - Tumor Suppressor Proteins -- metabolism KW - Tumor Suppressor Proteins -- genetics KW - Tumor Suppressor Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68470991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+and+molecular+medicine&rft.atitle=DLC-1%3Aa+Rho+GTPase-activating+protein+and+tumour+suppressor.&rft.au=Durkin%2C+Marian+E%3BYuan%2C+Bao-Zhu%3BZhou%2C+Xiaoling%3BZimonjic%2C+Drazen+B%3BLowy%2C+Douglas+R%3BThorgeirsson%2C+Snorri+S%3BPopescu%2C+Nicholas+C&rft.aulast=Durkin&rft.aufirst=Marian&rft.date=2007-09-01&rft.volume=11&rft.issue=5&rft.spage=1185&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+and+molecular+medicine&rft.issn=15821838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-04 N1 - Date created - 2007-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Structure and function of the human calcium-sensing receptor: insights from natural and engineered mutations and allosteric modulators. AN - 68470169; 17979873 AB - The human extracellular Ca(2+)-sensing receptor (CaR), a member of the G protein-coupled receptor family 3, plays a key role in the regulation of extracellular calcium homeostasis. It is one of just a few G protein-coupled receptors with a large number of naturally occurring mutations identified in patients. In contrast to the small sizes of its agonists, this large dimeric receptor consists of domains with topologically distinctive orthosteric and allosteric sites. Information derived from studies of naturally occurring mutations, engineered mutations, allosteric modulators and crystal structures of the agonist-binding domain of homologous type 1 metabotropic glutamate receptor and G protein-coupled rhodopsin offers new insights into the structure and function of the CaR. JF - Journal of cellular and molecular medicine AU - Hu, Jianxin AU - Spiegel, Allen M AD - Molecular Signalling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. jianxinh@niddk.nih.gov PY - 2007 SP - 908 EP - 922 VL - 11 IS - 5 SN - 1582-1838, 1582-1838 KW - Receptors, Calcium-Sensing KW - 0 KW - Index Medicus KW - Hyperparathyroidism -- metabolism KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Allosteric Regulation KW - Structure-Activity Relationship KW - Receptors, Calcium-Sensing -- chemistry KW - Receptors, Calcium-Sensing -- metabolism KW - Mutation -- genetics KW - Mutagenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68470169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+and+molecular+medicine&rft.atitle=Structure+and+function+of+the+human+calcium-sensing+receptor%3A+insights+from+natural+and+engineered+mutations+and+allosteric+modulators.&rft.au=Hu%2C+Jianxin%3BSpiegel%2C+Allen+M&rft.aulast=Hu&rft.aufirst=Jianxin&rft.date=2007-09-01&rft.volume=11&rft.issue=5&rft.spage=908&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+and+molecular+medicine&rft.issn=15821838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-04 N1 - Date created - 2007-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phase II trial of neoadjuvant gemcitabine and cisplatin in patients with resectable bladder carcinoma. AN - 68466991; 17980060 AB - Gemcitabine and cisplatin (GC) is an active combination in the treatment of metastatic bladder cancer. We have prospectively analyzed the efficacy and tolerability of GC as neoadjuvant treatment of invasive bladder cancer. In this single-institution phase II trial, patients with muscle-invasive transitional cell carcinoma received three cycles of gemcitabine 1200 mg/m2 on days 1 and 8 with cisplatin 75 mg/m2 on day 1 prior to surgery. Radiologic response was evaluated by computed tomography and magnetic resonance imaging. All patients were referred to surgery after chemotherapy completion. Between June 2002 and March 2005, 22 patients (19 males) were enrolled. Median age was 63 years. Initial stage was II (T2) in 11 and III (T3-4) in 11 patients. Median follow-up is 26 months (4-43). Partial or complete radiologic response rate was documented in 13 out of 20 assessable patients (70%). One patient was excluded due to sarcomatoid carcinoma at definitive pathologic examination. Cystectomy was performed in 15 patients and pelvic radiotherapy in four patients. Nine out of 21 patients (43%) relapsed and four (19%) died due to disease progression. Complete pathologic response was observed in four patients (26.7% of 15). Median progression-free survival was 27 months (CI 95% not reached) with median overall survival of 36 months (CI 95%: 28.7 - 43.3). Grade III/IV toxicity was infrequent, with no deaths due to chemotherapy. The combination of GC is effective and well-tolerated when used as neoadjuvant therapy in muscle-invasive bladder cancer. Longer follow-up is necessary to evaluate its impact on the overall survival of these patients. JF - International braz j urol : official journal of the Brazilian Society of Urology AU - Herchenhorn, Daniel AU - Dienstmann, Rodrigo AU - Peixoto, Fabio A AU - de Campos, Franz S AU - Santos, Valdelice O AU - Moreira, Denise M AU - Cardoso, Hedilene AU - Small, Isabele A AU - Ferreira, Carlos G AD - Department of Clinical Oncology, National Cancer Institute, Rio de Janeiro, RJ, Brazil. PY - 2007 SP - 630 EP - 8; discussion 638 VL - 33 IS - 5 SN - 1677-5538, 1677-5538 KW - Deoxycytidine KW - 0W860991D6 KW - gemcitabine KW - B76N6SBZ8R KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Disease-Free Survival KW - Deoxycytidine -- analogs & derivatives KW - Humans KW - Aged KW - Cisplatin -- administration & dosage KW - Prospective Studies KW - Adult KW - Treatment Outcome KW - Deoxycytidine -- administration & dosage KW - Middle Aged KW - Follow-Up Studies KW - Adolescent KW - Chemotherapy, Adjuvant KW - Female KW - Male KW - Carcinoma, Transitional Cell -- surgery KW - Urinary Bladder Neoplasms -- surgery KW - Urinary Bladder Neoplasms -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Carcinoma, Transitional Cell -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68466991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+braz+j+urol+%3A+official+journal+of+the+Brazilian+Society+of+Urology&rft.atitle=Phase+II+trial+of+neoadjuvant+gemcitabine+and+cisplatin+in+patients+with+resectable+bladder+carcinoma.&rft.au=Herchenhorn%2C+Daniel%3BDienstmann%2C+Rodrigo%3BPeixoto%2C+Fabio+A%3Bde+Campos%2C+Franz+S%3BSantos%2C+Valdelice+O%3BMoreira%2C+Denise+M%3BCardoso%2C+Hedilene%3BSmall%2C+Isabele+A%3BFerreira%2C+Carlos+G&rft.aulast=Herchenhorn&rft.aufirst=Daniel&rft.date=2007-09-01&rft.volume=33&rft.issue=5&rft.spage=630&rft.isbn=&rft.btitle=&rft.title=International+braz+j+urol+%3A+official+journal+of+the+Brazilian+Society+of+Urology&rft.issn=16775538&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-24 N1 - Date created - 2007-11-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Int Braz J Urol. 2007 Nov-Dec;33(6):840-1 [18199355] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Persistent hypocalcemia induced by zoledronic acid in a patient with androgen-independent prostate cancer and extensive bone metastases. AN - 68427570; 17956715 AB - Zoledronic acid is a highly potent bisphosphonate that has been shown to reduce skeletal-related events in patients with androgen-independent prostate cancer metastatic to bone. We report a patient with androgen-independent prostate cancer and extensive bone metastases. After receiving a single dose of zoledronic acid, the patient developed hypocalcemia that persisted for approximately 60 days despite intravenous and oral calcium supplementation, likely because of excess unopposed osteoblastic activity. This case underscores the need for calcium and vitamin D monitoring and supplementation to avoid bisphosphonate-induced secondary hyperparathyroidism and highlights the possibility that extensive osteoblastic metastasis alone might lead to hypocalcemia. JF - Clinical genitourinary cancer AU - Gulley, James L AU - Wu, Shenhong AU - Arlen, Philip M AU - Dahut, William L AD - Medical Oncology Branch, Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. gulleyj@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 403 EP - 405 VL - 5 IS - 6 SN - 1558-7673, 1558-7673 KW - Bone Density Conservation Agents KW - 0 KW - Diphosphonates KW - Imidazoles KW - zoledronic acid KW - 6XC1PAD3KF KW - Index Medicus KW - Bone Resorption -- prevention & control KW - Humans KW - Middle Aged KW - Male KW - Diphosphonates -- adverse effects KW - Imidazoles -- administration & dosage KW - Neoplasms, Hormone-Dependent -- drug therapy KW - Neoplasms, Hormone-Dependent -- pathology KW - Prostatic Neoplasms -- drug therapy KW - Hypocalcemia -- chemically induced KW - Bone Density Conservation Agents -- adverse effects KW - Prostatic Neoplasms -- pathology KW - Diphosphonates -- administration & dosage KW - Bone Neoplasms -- drug therapy KW - Adenocarcinoma -- secondary KW - Adenocarcinoma -- drug therapy KW - Bone Density Conservation Agents -- administration & dosage KW - Bone Neoplasms -- secondary KW - Imidazoles -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68427570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+genitourinary+cancer&rft.atitle=Persistent+hypocalcemia+induced+by+zoledronic+acid+in+a+patient+with+androgen-independent+prostate+cancer+and+extensive+bone+metastases.&rft.au=Gulley%2C+James+L%3BWu%2C+Shenhong%3BArlen%2C+Philip+M%3BDahut%2C+William+L&rft.aulast=Gulley&rft.aufirst=James&rft.date=2007-09-01&rft.volume=5&rft.issue=6&rft.spage=403&rft.isbn=&rft.btitle=&rft.title=Clinical+genitourinary+cancer&rft.issn=15587673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-03 N1 - Date created - 2007-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A second transient prostate-specific antigen elevation after external-beam radiation therapy and fractionated magnetic resonance imaging-guided high-dose rate brachytherapy boost. AN - 68426389; 17956716 AB - A 63-year-old man with a T1c adenocarcinoma of the prostate, Gleason score of 7 (4+3), and a pretreatment prostate-specific antigen (PSA) level of 9.5 ng/mL was treated with external-beam radiation therapy (45 Gy) and 2 magnetic resonance imaging-guided high-dose rate brachytherapy boosts (10 Gy each.) The patient also received neoadjuvant, concurrent, and adjuvant hormonal treatment with leuprolide for 7 months total. Without any further intervention the patient had 2 separate and prolonged PSA increases and decreases 12-35 months after therapy. His PSA nadir was <0.2 ng/mL and rose slowly over several months to 4.2 ng/mL, resolved, and then rose 2.3 ng/mL before again slowly resolving. After prostate irradiation, many patients experience a transient rise in serum PSA levels and a subsequent decline without any treatment. This is known as a PSA "bounce" or "bump." Some patients experience a second transient rise in PSA levels after irradiation. To our knowledge, this case report is the first documentation of a second PSA bump in a patient treated with external-beam radiation therapy and high-dose rate boost therapy and provides context to address concerns and therapeutic decisions confronting physicians and patients. JF - Clinical genitourinary cancer AU - Mishra, Mark V AU - Singh, Anurag K AD - Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 406 EP - 408 VL - 5 IS - 6 SN - 1558-7673, 1558-7673 KW - Antineoplastic Agents, Hormonal KW - 0 KW - Prostate-Specific Antigen KW - EC 3.4.21.77 KW - Leuprolide KW - EFY6W0M8TG KW - Index Medicus KW - Radiotherapy Dosage KW - Humans KW - Treatment Outcome KW - Middle Aged KW - Follow-Up Studies KW - Antineoplastic Agents, Hormonal -- therapeutic use KW - Male KW - Magnetic Resonance Imaging KW - Adenocarcinoma -- blood KW - Radiotherapy, Conformal KW - Brachytherapy -- adverse effects KW - Prostatic Neoplasms -- blood KW - Prostate-Specific Antigen -- blood KW - Prostatic Neoplasms -- drug therapy KW - Adenocarcinoma -- drug therapy KW - Prostatic Neoplasms -- radiotherapy KW - Adenocarcinoma -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68426389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+genitourinary+cancer&rft.atitle=A+second+transient+prostate-specific+antigen+elevation+after+external-beam+radiation+therapy+and+fractionated+magnetic+resonance+imaging-guided+high-dose+rate+brachytherapy+boost.&rft.au=Mishra%2C+Mark+V%3BSingh%2C+Anurag+K&rft.aulast=Mishra&rft.aufirst=Mark&rft.date=2007-09-01&rft.volume=5&rft.issue=6&rft.spage=406&rft.isbn=&rft.btitle=&rft.title=Clinical+genitourinary+cancer&rft.issn=15587673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-03 N1 - Date created - 2007-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Thymosin alpha1 as a chemopreventive agent in lung and breast cancer. AN - 68406532; 17567944 AB - The ability of thymosin alpha1 (Talpha1) to prevent lung and breast cancer was investigated. Lung adenomas developed in A/J mice injected with carcinogens, such as urethane. The lung adenoma number was reduced by 15-45% if animals were daily treated subcutaneously (s.c.) with Talpha1 (0.4 mg/kg). Talpha1 (1 microM) directly inhibited the growth of mouse lung cell lines. These results suggest that Talpha1 may prevent mouse lung carcinogenesis because it directly inhibits the growth of lung cancer cells. Talpha1 prevented mammary carcinogenesis in two animal models. In the Fisher rat, an animal model of mammary cancer that is estrogen receptor dependent, tumors were initiated by the injection of N-methylurea (NMU). The rat survival was significantly increased by the daily injection of Talpha1. In the SV40T antigen mouse, a transgenic female mouse that spontaneously gets mammary cancer in an estrogen receptor-independent manner, survival was increased and tumor burden was significantly decreased by daily injection of Talpha1. These results indicate that Talpha1 is a chemopreventive agent in animal models for lung and breast carcinogenesis. JF - Annals of the New York Academy of Sciences AU - Moody, Terry W AD - Department of Health and Human Services, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. moodyt@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 297 EP - 304 VL - 1112 SN - 0077-8923, 0077-8923 KW - Anticarcinogenic Agents KW - 0 KW - Thymosin KW - 61512-21-8 KW - thymalfasin KW - W0B22ISQ1C KW - Index Medicus KW - Rats KW - Mice, Inbred A KW - Animals KW - Rats, Inbred F344 KW - Adenoma -- prevention & control KW - Mice KW - Female KW - Lung Neoplasms -- prevention & control KW - Anticarcinogenic Agents -- therapeutic use KW - Thymosin -- therapeutic use KW - Mammary Neoplasms, Animal -- prevention & control KW - Thymosin -- analogs & derivatives KW - Mammary Neoplasms, Animal -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68406532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Thymosin+alpha1+as+a+chemopreventive+agent+in+lung+and+breast+cancer.&rft.au=Moody%2C+Terry+W&rft.aulast=Moody&rft.aufirst=Terry&rft.date=2007-09-01&rft.volume=1112&rft.issue=&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-27 N1 - Date created - 2007-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A fold-back single-chain diabody format enhances the bioactivity of an anti-monkey CD3 recombinant diphtheria toxin-based immunotoxin. AN - 68373271; 17693455 AB - T-cell depleting anti-CD3 immunotoxins have utility in non-human primate models of transplantation tolerance and autoimmune disease therapy. We recently reported that an affinity matured single-chain (scFv) anti-monkey CD3 antibody, C207, had increased binding to T-cells and increased bioactivity in a diphtheria toxin (DT)-based biscFv immunotoxin compared with the parental antibody, FN18. However, FN18 scFvs and their mutant derivatives such as C207 did not exhibit robust bivalent character in the biscFv format. We now report that C207 in a diabody format exhibits a 7-fold increase in binding to T-cells over scFv (C207) indicating considerable divalent character for the diabody. This construct was formed by reducing the V(L)/V(H) linker to five residues and was secreted from Pichia pastoris as the non-covalent dimer. An immunotoxin based on this diabody format was secreted as a non-covalent dimer but was devoid of bioactivity and failed to bind T-cells, suggesting steric hindrance from the two large closely positioned truncated DT moieties. We constructed a single-chain diabody immunotoxin by fusing to the truncated DT C-terminus L1-VL-L1-VH-L2-VL-L1-VH where L1 is a five-residue linker and L2 is the longer (G4S)3 linker permitting interactions between the distal and proximal VL/VH domains. This 'fold-back' immunotoxin was secreted predominantly as the monomer and exhibited a 5- to 7-fold increase in bioactivity over DT390biscFv(C207) and depleted monkey T-cells in vivo. JF - Protein engineering, design & selection : PEDS AU - Kim, Geun-Bae AU - Wang, Zhirui AU - Liu, Yuan Yi AU - Stavrou, Scott AU - Mathias, Askale AU - Goodwin, K Jeanine AU - Thomas, Judith M AU - Neville, David M AD - Section on Biophysical Chemistry, Laboratory of Molecular Biology, National Institute of Mental Health, Bldg 10, Room 3D46, 10 Center Drive, Bethesda, MD 20892-1216, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 425 EP - 432 VL - 20 IS - 9 SN - 1741-0126, 1741-0126 KW - Antigens, CD3 KW - 0 KW - Diphtheria Toxin KW - Immunoglobulin Fragments KW - Immunotoxins KW - Recombinant Fusion Proteins KW - Index Medicus KW - Animals KW - T-Lymphocytes -- metabolism KW - Plasmids -- metabolism KW - Dimerization KW - Pichia -- metabolism KW - Time Factors KW - Haplorhini KW - Recombinant Fusion Proteins -- chemistry KW - Immunoglobulin Fragments -- chemistry KW - Immunotoxins -- chemistry KW - Antigens, CD3 -- chemistry KW - Diphtheria Toxin -- chemistry KW - Protein Engineering -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68373271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+engineering%2C+design+%26+selection+%3A+PEDS&rft.atitle=A+fold-back+single-chain+diabody+format+enhances+the+bioactivity+of+an+anti-monkey+CD3+recombinant+diphtheria+toxin-based+immunotoxin.&rft.au=Kim%2C+Geun-Bae%3BWang%2C+Zhirui%3BLiu%2C+Yuan+Yi%3BStavrou%2C+Scott%3BMathias%2C+Askale%3BGoodwin%2C+K+Jeanine%3BThomas%2C+Judith+M%3BNeville%2C+David+M&rft.aulast=Kim&rft.aufirst=Geun-Bae&rft.date=2007-09-01&rft.volume=20&rft.issue=9&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Protein+engineering%2C+design+%26+selection+%3A+PEDS&rft.issn=17410126&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-13 N1 - Date created - 2007-10-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets. AN - 68332364; 17908040 AB - As the average ages of North Americans and Europeans continue to rise; similarly the incidence of "old age" associated illnesses likewise increases. Most notably among these ailments are conditions linked to dementia-related neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD) and stroke. While in the early stages, these conditions are associated with cellular dysfunction in distinctly different brain regions, thus affecting different neuronal cell types; it is most likely that the final stages share similar cellular and molecular processes leading to neuronal death and ultimately overt clinical symptoms. In this regard, different environmental and genetic triggers ranging from head trauma to protein mutations and toxicological exposure may instigate a cascade of intracellular events that ultimately lead to neuronal death. One strong candidate trigger protein, and thus a potential target for therapeutic manipulation is the potent pro-inflammatory / pro-apoptotic cytokine, tumor necrosis factor-alpha (TNF-alpha). TNF-alpha is secreted by the brain resident marcophage (the microglial cell) in response to various stimuli. It has been demonstrated to play a major role in central nervous system (CNS) neuroinflammation-mediated cell death in AD, PD and amyotrophic lateral sclerosis (ALS) as well as several other CNS complications. Recently, agents that modulate the levels of circulating peripheral TNF-alpha protein have been shown to be worthwhile therapeutic agents with the use of Enbrel (Etanercept) and Remicade (Infliximab), both of which display beneficial properties against rheumatoid arthritis and other peripheral inflammatory diseases. Unfortunately, these agents are largely unable to penetrate the blood-brain barrier, which severely limits their use in the setting of neuroinflammation in the CNS. However, thalidomide, a small molecule drug, can inhibit TNF-alpha protein synthesis and, unlike larger molecules, is readily capable of crossing the blood-brain barrier. Thus thalidomide and its analogs are excellent candidate agents for use in determining the potential value of anti-TNF-alpha therapies in a variety of diseases underpinned by inflammation within the nervous system. Consequently, we have chosen to discuss the relevance of unregulated TNF-alpha expression in illnesses of the CNS and, to an extent, the peripheral nervous system. Additionally, we consider the utilization of thalidomide-derived agents as anti-TNF-alpha therapeutics in the setting of neuroinflammation. JF - Current Alzheimer research AU - Tweedie, David AU - Sambamurti, Kumar AU - Greig, Nigel H AD - Drug Design & Development Section, Laboratory of Neurosciences, Intramural Research Program, NIA, NIH, Baltimore, MD 21224, USA. Tweedieda@grc.nia.nih.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 378 EP - 385 VL - 4 IS - 4 SN - 1567-2050, 1567-2050 KW - Enzyme Inhibitors KW - 0 KW - Tumor Necrosis Factor-alpha KW - Index Medicus KW - Animals KW - Humans KW - Neurodegenerative Diseases -- drug therapy KW - Enzyme Inhibitors -- therapeutic use KW - Tumor Necrosis Factor-alpha -- physiology KW - Tumor Necrosis Factor-alpha -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68332364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Alzheimer+research&rft.atitle=TNF-alpha+inhibition+as+a+treatment+strategy+for+neurodegenerative+disorders%3A+new+drug+candidates+and+targets.&rft.au=Tweedie%2C+David%3BSambamurti%2C+Kumar%3BGreig%2C+Nigel+H&rft.aulast=Tweedie&rft.aufirst=David&rft.date=2007-09-01&rft.volume=4&rft.issue=4&rft.spage=378&rft.isbn=&rft.btitle=&rft.title=Current+Alzheimer+research&rft.issn=15672050&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-01 N1 - Date created - 2007-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in the Central and Eastern European Kidney Cancer Study. AN - 68327410; 17617661 AB - High consumption of cruciferous vegetables has been associated with reduced kidney cancer risk in many studies. Isothiocyanates, thought to be responsible for the chemopreventive properties of this food group, are conjugated to glutathione by glutathione S-transferases (GSTs) before urinary excretion. Modification of this relationship by host genetic factors is unknown. We investigated cruciferous vegetable intake in 1097 cases and 1555 controls enrolled in a multicentric case-control study from the Czech Republic, Poland, Romania and Russia. To assess possible gene-diet interactions, genotyped cases (N = 925) and controls (N = 1247) for selected functional or non-synonymous polymorphisms including the GSTM1 deletion, GSTM3 3 bp deletion (IVS6 + 22-AGG) and V224I G>A substitution, GSTT1 deletion and the GSTP1 I105V A>G substitution. The odds ratio (OR) for low (less than once per month) versus high (at least once per week) intake of cruciferous vegetables was 1.29 [95% confidence interval (CI): 1.02-1.62; P-trend = 0.03]. When low intake of cruciferous vegetables (less than once per month) was stratified by GST genotype, higher kidney cancer risks were observed among individuals with the GSTT1 null (OR = 1.86; 95% CI: 1.07-3.23; P-interaction = 0.05) or with both GSTM1/T1 null genotypes (OR = 2.49; 95% CI: 1.08-5.77; P-interaction = 0.05). These data provide additional evidence for the role of cruciferous vegetables in cancer prevention among individuals with common, functional genetic polymorphisms. JF - Carcinogenesis AU - Moore, L E AU - Brennan, P AU - Karami, S AU - Hung, R J AU - Hsu, C AU - Boffetta, P AU - Toro, J AU - Zaridze, D AU - Janout, V AU - Bencko, V AU - Navratilova, M AU - Szeszenia-Dabrowska, N AU - Mates, D AU - Mukeria, A AU - Holcatova, I AU - Welch, R AU - Chanock, S AU - Rothman, N AU - Chow, W-H AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. moorele@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 1960 EP - 1964 VL - 28 IS - 9 SN - 0143-3334, 0143-3334 KW - DNA KW - 9007-49-2 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Humans KW - Aged KW - Europe -- epidemiology KW - Feeding Behavior KW - Genotype KW - DNA -- isolation & purification KW - Europe, Eastern -- epidemiology KW - Risk Factors KW - DNA -- blood KW - Adult KW - DNA -- genetics KW - Interviews as Topic KW - Middle Aged KW - Male KW - Female KW - Sequence Deletion KW - Kidney Neoplasms -- genetics KW - Vegetables KW - Brassicaceae KW - Polymorphism, Genetic KW - Kidney Neoplasms -- epidemiology KW - Glutathione Transferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68327410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Glutathione+S-transferase+polymorphisms%2C+cruciferous+vegetable+intake+and+cancer+risk+in+the+Central+and+Eastern+European+Kidney+Cancer+Study.&rft.au=Moore%2C+L+E%3BBrennan%2C+P%3BKarami%2C+S%3BHung%2C+R+J%3BHsu%2C+C%3BBoffetta%2C+P%3BToro%2C+J%3BZaridze%2C+D%3BJanout%2C+V%3BBencko%2C+V%3BNavratilova%2C+M%3BSzeszenia-Dabrowska%2C+N%3BMates%2C+D%3BMukeria%2C+A%3BHolcatova%2C+I%3BWelch%2C+R%3BChanock%2C+S%3BRothman%2C+N%3BChow%2C+W-H&rft.aulast=Moore&rft.aufirst=L&rft.date=2007-09-01&rft.volume=28&rft.issue=9&rft.spage=1960&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-14 N1 - Date created - 2007-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transforming growth factor beta 1 (TGFB1) gene polymorphisms and risk of advanced colorectal adenoma. AN - 68327365; 17615257 AB - Transforming growth factor beta 1 (TGFB1) is a multifunctional cytokine that has been implicated in the pathogenesis of colorectal neoplasia. To investigate the association between genetic variants in TGFB1 and the risk of colorectal adenoma, we conducted a case-control study of 754 advanced adenoma cases and 769 controls from the baseline screening exam of the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Cases included participants diagnosed with advanced left-sided adenoma (>or=1 cm, high-grade dysplasia or villous characteristics), and controls were subjects without evidence of a left-sided polyp by sigmoidoscopy. DNA was extracted from blood specimens, and five single-nucleotide polymorphisms in TGFB1 of known or suggested functional significance (-800G>A, -509C>T, Leu10Pro, Arg25Pro and Thr263Ile) were genotyped. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) for the association between each polymorphism and adenoma. The high TGFB1 producer genotypes, -509TT and 10Pro/Pro, were associated with an increased risk of colorectal adenoma compared with other genotypes (OR = 1.51, 95% CI: 1.04-2.20 and OR = 1.37, 95% CI: 1.02-1.86, respectively). These increased risks, particularly for -509TT, were greater for persons with multiple adenomas (OR = 1.89, 95% CI: 1.16-3.09, P = 0.01) and individuals with rectal adenoma (OR = 2.95, 95% CI: 1.66-5.26, P = 0.0002). Haplotype analysis revealed similar findings under a recessive model. No associations were observed for polymorphisms at codons 25 and 263. In conclusion, variants that enhance TGFB1 production may be associated with an increased risk of advanced colorectal adenoma. JF - Carcinogenesis AU - Berndt, Sonja I AU - Huang, Wen-Yi AU - Chatterjee, Nilanjan AU - Yeager, Meredith AU - Welch, Robert AU - Chanock, Stephen J AU - Weissfeld, Joel L AU - Schoen, Robert E AU - Hayes, Richard B AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. berndts@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 1965 EP - 1970 VL - 28 IS - 9 SN - 0143-3334, 0143-3334 KW - TGFB1 protein, human KW - 0 KW - Transforming Growth Factor beta1 KW - Index Medicus KW - Genetic Variation KW - Reference Values KW - Neoplasm Staging KW - Humans KW - Aged KW - Gene Expression Regulation, Neoplastic KW - Genotype KW - Incidence KW - Middle Aged KW - Adenoma -- genetics KW - United States -- epidemiology KW - Female KW - Male KW - Polymorphism, Genetic KW - Colorectal Neoplasms -- pathology KW - Transforming Growth Factor beta1 -- genetics KW - Colorectal Neoplasms -- genetics KW - Colorectal Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68327365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Transforming+growth+factor+beta+1+%28TGFB1%29+gene+polymorphisms+and+risk+of+advanced+colorectal+adenoma.&rft.au=Berndt%2C+Sonja+I%3BHuang%2C+Wen-Yi%3BChatterjee%2C+Nilanjan%3BYeager%2C+Meredith%3BWelch%2C+Robert%3BChanock%2C+Stephen+J%3BWeissfeld%2C+Joel+L%3BSchoen%2C+Robert+E%3BHayes%2C+Richard+B&rft.aulast=Berndt&rft.aufirst=Sonja&rft.date=2007-09-01&rft.volume=28&rft.issue=9&rft.spage=1965&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-14 N1 - Date created - 2007-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Preventive effect of diabegon, a polyherbal preparation, during progression of diabetes induced by high-fructose feeding in rats. AN - 68313590; 17878707 AB - In the present study, the polyherbal preparation diabegon, containing 18 plant extracts with hypoglycemic activity, was evaluated for its preventive effect during progression of type 2 diabetes in high-fructose-diet-fed rats. Oral administration of diabegon (100 mg/kg body weight) delayed development of glucose intolerance for 4 weeks in comparison with the diabetic control group, and the effect of diabegon was compared to that of the standard insulin sensitizer drug rosiglitazone. Diabegon treatment also ameliorated the elevation of glycosylated haemoglobin, liver glycogen content, plasma insulin, homeostasis model assessment, free fatty acids, triglycerides, total cholesterol, LDL-cholesterol, and VLDL-cholesterol, whereas it increased HDL-cholesterol after 56 days of treatment (P<0.05). The mechanism of action by which diabegon attenuates insulin resistance and dyslipidemia may be through induction of peroxisome proliferator-activated receptor-gamma and lipoprotein lipase activity in peripheral tissues (muscles). Moreover, diabegon administration for 56 days also produced no alteration in liver and kidney function tests, which seems to indicate its non-toxicity during treatment. Our present results suggest that diabegon may be included in diabetes mellitus treatment regimens, as a drug with good antidiabetic actions but no toxic manifestations. JF - Journal of pharmacological sciences AU - Yadav, Hariom AU - Jain, Shalini AU - Prasad, G B K S AU - Yadav, Mukesh AD - School of Studies in Biochemistry, Jiwaji University, Gwalior-474011, Madhya Prakesh, India. yadavh@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 12 EP - 21 VL - 105 IS - 1 SN - 1347-8613, 1347-8613 KW - Blood Glucose KW - 0 KW - Hemoglobin A, Glycosylated KW - Hypoglycemic Agents KW - Insulin KW - Lipids KW - PPAR gamma KW - Plant Extracts KW - diabegon KW - glucosylated hemoglobin A KW - Fructose KW - 30237-26-4 KW - Glycogen KW - 9005-79-2 KW - Lipoprotein Lipase KW - EC 3.1.1.34 KW - Index Medicus KW - Lipids -- blood KW - Administration, Oral KW - Animals KW - Glucose Tolerance Test KW - Blood Glucose -- metabolism KW - Hyperglycemia -- prevention & control KW - Insulin -- blood KW - Kidney -- drug effects KW - Liver -- metabolism KW - Hemoglobin A, Glycosylated -- analogs & derivatives KW - Homeostasis -- drug effects KW - Rats KW - Liver -- physiopathology KW - Glycogen -- metabolism KW - Liver -- drug effects KW - Lipoprotein Lipase -- metabolism KW - Hemoglobin A, Glycosylated -- metabolism KW - Rats, Wistar KW - PPAR gamma -- metabolism KW - Insulin Resistance KW - Male KW - Kidney -- physiopathology KW - Hyperglycemia -- blood KW - Plant Extracts -- pharmacology KW - Hypoglycemic Agents -- therapeutic use KW - Fructose -- toxicity KW - Plant Extracts -- therapeutic use KW - Hypoglycemic Agents -- administration & dosage KW - Diabetes Mellitus, Experimental -- prevention & control KW - Fructose -- administration & dosage KW - Diabetes Mellitus, Experimental -- chemically induced KW - Diabetes Mellitus, Experimental -- blood KW - Hypoglycemic Agents -- pharmacology KW - Plant Extracts -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68313590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pharmacological+sciences&rft.atitle=Preventive+effect+of+diabegon%2C+a+polyherbal+preparation%2C+during+progression+of+diabetes+induced+by+high-fructose+feeding+in+rats.&rft.au=Yadav%2C+Hariom%3BJain%2C+Shalini%3BPrasad%2C+G+B+K+S%3BYadav%2C+Mukesh&rft.aulast=Yadav&rft.aufirst=Hariom&rft.date=2007-09-01&rft.volume=105&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Journal+of+pharmacological+sciences&rft.issn=13478613&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-20 N1 - Date created - 2007-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A genetic screen for DNA double-strand break repair mutations in Drosophila. AN - 68304761; 17660539 AB - The study of DNA double-strand break (DSB) repair has been greatly facilitated by the use of rare-cutting endonucleases, which induce a break precisely at their cut sites that can be strategically placed in the genome. We previously established such a system in Drosophila and showed that the yeast I-SceI enzyme cuts efficiently in Drosophila cells and those breaks are effectively repaired by conserved mechanisms. In this study, we determined the genetic requirements for the repair of this I-SceI-induced DSB in the germline. We show that Drosophila Rad51 and Rad54 are both required for homologous repair by gene conversion, but are dispensable for single-strand annealing repair. We provided evidence suggesting that Rad51 is more stringently required than Rad54 for intersister gene conversion. We uncovered a significant role of DNA ligase IV in nonhomologous end joining. We conducted a screen for candidate mutations affecting DSB repair and discovered novel mutations in genes that include mutagen sensitive 206, single-strand annealing reducer, and others. In addition, we demonstrated an intricate balance among different repair pathways in which the cell differentially utilizes repair mechanisms in response to both changes in the genomic environment surrounding the break and deficiencies in one or the other repair pathways. JF - Genetics AU - Wei, Debbie S AU - Rong, Yikang S AD - Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 63 EP - 77 VL - 177 IS - 1 SN - 0016-6731, 0016-6731 KW - DNA, Cruciform KW - 0 KW - DNA-Binding Proteins KW - DNL4 protein, S cerevisiae KW - Drosophila Proteins KW - Egg Proteins KW - Saccharomyces cerevisiae Proteins KW - SCEI protein, S cerevisiae KW - EC 3.1.21.- KW - Deoxyribonucleases, Type II Site-Specific KW - EC 3.1.21.4 KW - okra protein, Drosophila KW - EC 3.6.1.3 KW - DNA Helicases KW - EC 3.6.4.- KW - DNA Ligases KW - EC 6.5.1.- KW - DNA Ligase ATP KW - EC 6.5.1.1 KW - Index Medicus KW - Animals KW - Egg Proteins -- genetics KW - DNA-Binding Proteins -- genetics KW - Animals, Genetically Modified KW - Deoxyribonucleases, Type II Site-Specific -- metabolism KW - Egg Proteins -- metabolism KW - Crosses, Genetic KW - Drosophila Proteins -- genetics KW - DNA Ligases -- metabolism KW - DNA, Cruciform -- physiology KW - Drosophila Proteins -- metabolism KW - Male KW - Female KW - DNA-Binding Proteins -- metabolism KW - DNA Repair -- physiology KW - Drosophila melanogaster -- genetics KW - Signal Transduction -- genetics KW - DNA Breaks, Double-Stranded UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68304761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+and+Medicine&rft.atitle=How+do+patients+evaluate+and+make+use+of+online+health+information%3F&rft.au=Sillence%2C+E%3BBriggs%2C+P%3BHarris%2C+PR%3BFishwick%2C+L&rft.aulast=Sillence&rft.aufirst=E&rft.date=2007-05-01&rft.volume=64&rft.issue=9&rft.spage=1853&rft.isbn=&rft.btitle=&rft.title=Social+Science+and+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2007.01.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-18 N1 - Date created - 2007-09-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell. 1999 Oct;4(4):511-8 [10549283] Genetics. 1999 Jul;152(3):1025-35 [10388821] Science. 2000 Jun 16;288(5473):2013-8 [10856208] Mol Cell Biol. 2000 Jul;20(14):5300-9 [10866686] EMBO J. 2000 Jul 3;19(13):3398-407 [10880452] J Cell Biol. 2000 Jul 24;150(2):F31-6 [10908583] Curr Genet. 2000 Oct;38(3):113-25 [11057444] Mol Cell. 2001 Feb;7(2):263-72 [11239455] Science. 2001 Mar 30;291(5513):2600-2 [11283371] Genetics. 2001 Oct;159(2):515-25 [11606529] Genetics. 2002 Jul;161(3):1015-27 [12136007] Genetics. 1999 Jul;152(3):1037-44 [10388822] Genetics. 2004 Nov;168(3):1477-89 [15579700] Nucleic Acids Res. 2005 Jan 1;33(Database issue):D390-5 [15608223] Genetics. 2004 Dec;168(4):2067-76 [15611176] Genetics. 2005 Feb;169(2):795-806 [15545651] Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15167-72 [16203987] DNA Repair (Amst). 2005 Nov 21;4(11):1281-94 [16043424] Annu Rev Genet. 2005;39:431-51 [16285867] Genetics. 2006 Feb;172(2):1055-68 [16299390] Curr Biol. 2006 Oct 24;16(20):2009-15 [17055979] Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16370-5 [17060623] Nature. 2002 Nov 7;420(6911):93-8 [12422221] Mol Cell. 2002 Nov;10(5):1189-99 [12453425] Microbiol Mol Biol Rev. 2002 Dec;66(4):630-70, table of contents [12456786] Mol Cell. 2002 Dec;10(6):1503-9 [12504024] Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16840-5 [17075047] Genetics. 2007 Mar;175(3):1023-33 [17194776] PLoS Genet. 2007 Apr 13;3(4):e50 [17432935] Science. 2003 Jan 10;299(5604):265-7 [12522255] Genetics. 2003 Jun;164(2):589-601 [12807779] Mol Cell. 2003 Jul;12(1):209-19 [12887906] Mol Cell. 2003 Jul;12(1):221-32 [12887907] Genetics. 2003 Sep;165(1):197-204 [14504227] EMBO J. 2003 Nov 3;22(21):5863-74 [14592983] Genetics. 2003 Dec;165(4):1831-42 [14704169] Genetics. 2003 Dec;165(4):1929-41 [14704177] Development. 2004 Mar;131(5):1029-39 [14973288] Genetics. 2004 May;167(1):217-31 [15166149] Genetics. 2004 Jun;167(2):699-705 [15238522] Curr Biol. 2004 Aug 10;14(15):1348-53 [15296751] Mutat Res. 1973 Nov;20(2):215-20 [4356741] Mutat Res. 1974 Sep;24(3):281-92 [4606119] Genetics. 1976 Nov;84(3):507-26 [826451] Genetics. 1981 Mar-Apr;97(3-4):607-23 [6795083] Cell. 1983 May;33(1):25-35 [6380756] EMBO J. 1990 Mar;9(3):663-73 [2178924] Cell. 1990 Aug 10;62(3):515-25 [2165865] Genetics. 1992 Oct;132(2):387-402 [1427035] Nucleic Acids Res. 1993 Nov 11;21(22):5034-40 [8255757] Mol Cell Biol. 1994 Mar;14(3):1613-25 [8114699] EMBO J. 1994 Mar 15;13(6):1450-9 [7907981] Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):6064-8 [8016116] Mol Cell Biol. 1995 Apr;15(4):2245-51 [7891718] Cell. 1995 Sep 8;82(5):815-21 [7671309] Genetics. 1995 Oct;141(2):619-27 [8647398] Genetics. 1996 Mar;142(3):693-704 [8849880] Nucleic Acids Res. 1996 Dec 1;24(23):4639-48 [8972848] Nature. 1997 Jul 31;388(6641):495-8 [9242411] Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9214-9 [9256462] Nucleic Acids Res. 1997 Sep 15;25(18):3665-71 [9278488] Genes Dev. 1998 Sep 1;12(17):2711-23 [9732269] Microbiol Mol Biol Rev. 1999 Jun;63(2):349-404 [10357855] Cell. 1999 Dec 23;99(7):723-33 [10619426] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acute pesticide poisoning among cut-flower farmers. AN - 68302960; 17886581 AB - The study reported here looked at adverse health effects associated with pesticide exposure among cut-flower farmers in La Trinidad, Philippines. Survey questionnaires and detailed physical and laboratory examinations were administered to 114 and 102 respondents, respectively, to determine pesticide exposure, work and safety practices, individual and family illnesses, and cholinesterase levels. Results showed that pesticide application was the activity most frequently associated with pesticide exposure, and entry was mostly ocular and dermal. Involvement of the skin was noted, with 21 percent of farmers having integumentary abnormalities. Upon physical examination, 90 respondents, or 88.2 percent of those examined, were found to have abnormal peak expiratory flow rate (PEFR). Abnormal temperature was found in 81.3 percent, and the next most frequent finding was abnormal general-survey results, at 75.5 percent. In 51 percent, cholinesterase levels were below the mean value of 0.7 delta pH/hour. (The unit of measure A pH/hour refers to the change in cholinesterase activity as measured by the difference between the initial pH and the final pH when acetylcholine solution has been added to the red blood cell for 1 1/2 hours. A decrease in cholinesterase activity will produce a low delta pH/hour level) In 25.5 percent, a more than 10 percent depression in the level of RBC cholinesterase was found. Certain hematological parameters were also abnormal, namely hemoglobin, hematocrit, and eosinophil count. Using Pearson's r, the author found that factors strongly associated with illness due to pesticides include use of a contaminated piece of fabric to wipe off sweat (p = .01) and reuse of pesticide containers to store water (p = .01), Recycling of containers poses great health hazards and risks of contamination, and the current recommendation is that used containers should be buried. There was a moderate relationship between illness and average number of years of pesticide use (p = .05), and between illness and re-entering a recently sprayed area (p = .05). Those with motor scale scores of < or = 15--normal values--were less likely to be sick. The greatest adverse effect in those exposed was an abnormal cholinesterase level, a finding that confirms results from earlier studies on the effect of pesticides on the body. JF - Journal of environmental health AU - Lu, Jinky Leilanie AD - University of the Philippines, National Institutes of Health, Quezon City. jinky_lu@yahoo.com Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 38 EP - 43 VL - 70 IS - 2 SN - 0022-0892, 0022-0892 KW - Pesticides KW - 0 KW - Cholinesterases KW - EC 3.1.1.8 KW - Index Medicus KW - Agriculture KW - Flowers KW - Cholinesterases -- blood KW - Aged, 80 and over KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Aged KW - Middle Aged KW - Adolescent KW - Philippines -- epidemiology KW - Male KW - Female KW - Inhalation Exposure -- adverse effects KW - Agricultural Workers' Diseases -- epidemiology KW - Agricultural Workers' Diseases -- chemically induced KW - Occupational Exposure -- adverse effects KW - Agricultural Workers' Diseases -- blood KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68302960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+health&rft.atitle=Acute+pesticide+poisoning+among+cut-flower+farmers.&rft.au=Lu%2C+Jinky+Leilanie&rft.aulast=Lu&rft.aufirst=Jinky&rft.date=2007-09-01&rft.volume=70&rft.issue=2&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+health&rft.issn=00220892&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-02 N1 - Date created - 2007-09-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Real-time imaging of convection-enhanced delivery of viruses and virus-sized particles. AN - 68299763; 17886556 AB - Despite recent evidence showing that convection-enhanced delivery (CED) of viruses and virus-sized particles to the central nervous system (CNS) is possible, little is known about the factors influencing distribution of these vectors with convection. To better define the delivery of viruses and virus-sized particles in the CNS, and to determine optimal parameters for infusion, the authors coinfused adeno-associated virus ([AAV], 24-nm diameter) and/or ferumoxtran-10 (24 nm) by using CED during real-time magnetic resonance (MR) imaging. Sixteen rats underwent intrastriatal convective coinfusion with 4 microl of 35S-AAV capsids (0.5-1.0 x 10(14) viral particles/ml) and increasing concentrations (0.1, 0.5, 1, and 5 mg/ml) of a similar sized iron oxide MR imaging agent (ferumoxtran-10). Five nonhuman primates underwent either convective coinfusion of 35S-AAV capsids and 1 mg/ml ferumoxtran-10 (striatum, one animal) or infusion of 1 mg/ml ferumoxtran-10 alone (striatum in two animals; frontal white matter in two). Clinical effects, MR imaging studies, quantitative autoradiography, and histological data were analyzed. Real-time, T2-weighted MR imaging of ferumoxtran-10 during infusion revealed a clearly defined hypointense region of perfusion. Quantitative autoradiography confirmed that MR imaging of ferumoxtran-10 at a concentration of 1 mg/ml accurately tracked viral capsid distribution in the rat and primate brain (the mean difference in volume of distribution [Vd] was 7 and 15% in rats and primates, respectively). The Vd increased linearly with increasing volume of infusion (Vi) (R2 = 0.98). The mean Vd/Vi ratio was 4.1 +/- 0.2 (mean +/- standard error of the mean) in gray and 2.3 +/- 0.1 in white matter (p < 0.01). The distribution of infusate was homogeneous. Postinfusion MR imaging revealed leakback along the cannula track at infusion rates greater than 1.5 microl/minute in primate gray and white matter. No animal had clinical or histological evidence of toxicity. The CED method can be used to deliver AAV capsids and similar sized particles to the CNS safely and effectively over clinically relevant volumes. Moreover, real-time MR imaging of ferumoxtran-10 during infusion reveals that AAV capsids and similar sized particles have different convective delivery properties than smaller proteins and other compounds. JF - Journal of neurosurgery AU - Szerlip, Nicholas J AU - Walbridge, Stuart AU - Yang, Linda AU - Morrison, Paul F AU - Degen, Jeffrey W AU - Jarrell, S Taylor AU - Kouri, Joshua AU - Kerr, P Benjamin AU - Kotin, Robert AU - Oldfield, Edward H AU - Lonser, Russell R AD - Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1414, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 560 EP - 567 VL - 107 IS - 3 SN - 0022-3085, 0022-3085 KW - Contrast Media KW - 0 KW - Dextrans KW - Magnetite Nanoparticles KW - Oxides KW - ferumoxtran-10 KW - Iron KW - E1UOL152H7 KW - Ferrosoferric Oxide KW - XM0M87F357 KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Magnetic Resonance Imaging KW - Convection KW - Animals KW - Rats, Sprague-Dawley KW - Macaca fascicularis KW - Particle Size KW - Infusions, Parenteral KW - Image Processing, Computer-Assisted KW - Genetic Vectors -- administration & dosage KW - Oxides -- administration & dosage KW - Contrast Media -- pharmacokinetics KW - Iron -- administration & dosage KW - Iron -- pharmacokinetics KW - Oxides -- pharmacokinetics KW - Contrast Media -- administration & dosage KW - Brain -- metabolism KW - Genetic Vectors -- pharmacokinetics KW - Dependovirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68299763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurosurgery&rft.atitle=Real-time+imaging+of+convection-enhanced+delivery+of+viruses+and+virus-sized+particles.&rft.au=Szerlip%2C+Nicholas+J%3BWalbridge%2C+Stuart%3BYang%2C+Linda%3BMorrison%2C+Paul+F%3BDegen%2C+Jeffrey+W%3BJarrell%2C+S+Taylor%3BKouri%2C+Joshua%3BKerr%2C+P+Benjamin%3BKotin%2C+Robert%3BOldfield%2C+Edward+H%3BLonser%2C+Russell+R&rft.aulast=Szerlip&rft.aufirst=Nicholas&rft.date=2007-09-01&rft.volume=107&rft.issue=3&rft.spage=560&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurosurgery&rft.issn=00223085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-11 N1 - Date created - 2007-09-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Seroprevalence of hepatitis C virus and hepatitis B virus among San Francisco injection drug users, 1998 to 2000. AN - 68298838; 17657818 AB - Previous studies suggest that most injection drug users (IDUs) become infected with hepatitis C virus (HCV) and hepatitis B virus (HBV) soon after initiating drug use. The Urban Health Study (UHS) recruited serial cross-sections of IDUs in the San Francisco Bay area from 1986 to 2005. In the current study, we determined the prevalence of antibody to HCV and HBV (core) among UHS participants during 1998 to 2000. To examine whether the time from onset of injection to acquisition of viral hepatitis has increased, we also compared the findings among recent (<10 years) initiates to drug use who participated during 1998-2000 with those who participated in 1987. Of 2,296 IDUs who participated during 1998-2000, 91.1% had antibody to HCV and 80.5% to HBV. The number of years a person had injected drugs strongly predicted infection with either virus (P(trend) < 0.0001). HCV seroprevalence among recent initiates in 1998-2000, by years of injection drug use, was: 100% predicted) or poor (70% after only 20 mg/kg of busulfan. Similar levels of engraftment were achieved even when infusion of BMNCs was delayed up to 20 days after busulfan injection. Nonmyeloablative parenteral busulfan produced transient myelosuppressive effects, clinically relevant levels of engraftment, and an extended time window for HSC infusion in murine hosts. JF - Experimental hematology AU - Hsieh, Matthew M AU - Langemeijer, Saskia AU - Wynter, Aisha AU - Phang, Oswald A AU - Kang, Elizabeth M AU - Tisdale, John F AD - Molecular and Clinical Hematology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 1415 EP - 1420 VL - 35 IS - 9 SN - 0301-472X, 0301-472X KW - Busulfan KW - G1LN9045DK KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Graft Survival KW - Mice, Inbred C57BL KW - Mice KW - Time Factors KW - Infusions, Parenteral KW - Leukocyte Count KW - Platelet Count KW - Busulfan -- administration & dosage KW - Busulfan -- pharmacology KW - Hematopoietic Stem Cell Transplantation -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68219980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+hematology&rft.atitle=Low-dose+parenteral+busulfan+provides+an+extended+window+for+the+infusion+of+hematopoietic+stem+cells+in+murine+hosts.&rft.au=Hsieh%2C+Matthew+M%3BLangemeijer%2C+Saskia%3BWynter%2C+Aisha%3BPhang%2C+Oswald+A%3BKang%2C+Elizabeth+M%3BTisdale%2C+John+F&rft.aulast=Hsieh&rft.aufirst=Matthew&rft.date=2007-09-01&rft.volume=35&rft.issue=9&rft.spage=1415&rft.isbn=&rft.btitle=&rft.title=Experimental+hematology&rft.issn=0301472X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-01 N1 - Date created - 2007-08-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biol Blood Marrow Transplant. 2007 Jan;13(1):56-64 [17222753] Curr Opin Hematol. 2007 Jan;14(1):29-36 [17133097] Mol Ther. 2000 Jun;1(6):533-44 [10933978] Hum Gene Ther. 2007 Jan;18(1):1-9 [17173507] Exp Hematol. 2001 Jun;29(6):779-85 [11378274] Mol Ther. 2001 Jun;3(6):911-9 [11407905] J Immunol. 2001 Jul 15;167(2):1103-11 [11441122] Hum Gene Ther. 2001 Sep 1;12(13):1663-72 [11535169] N Engl J Med. 2002 Apr 18;346(16):1185-93 [11961146] J Clin Immunol. 2002 Mar;22(2):70-4 [11998895] Science. 2002 Jun 28;296(5577):2410-3 [12089448] Biol Blood Marrow Transplant. 2002;8(9):486-92 [12374453] Int J Hematol. 2002 Aug;76 Suppl 2:271-7 [12430936] Int J Hematol. 2003 Jan;77(1):3-14 [12568294] Hematology Am Soc Hematol Educ Program. 2003;:372-97 [14633791] Blood. 2004 Aug 1;104(3):857-64 [15073038] Semin Hematol. 2004 Oct;41(4):279-86 [15508113] J Natl Cancer Inst. 1974 Dec;53(6):1781-5 [4612168] Exp Hematol. 1974;2(3):101-17 [4616840] N Engl J Med. 1983 Dec 1;309(22):1347-53 [6355849] Transplantation. 1988 Aug;46(2):205-10 [3043777] Blood. 1991 Dec 15;78(12):3312-6 [1683798] Blood. 1996 May 15;87(10):4049-56 [8639760] N Engl J Med. 1996 Aug 8;335(6):369-76 [8663884] Hum Gene Ther. 1999 Jul 20;10(11):1783-90 [10446918] Lancet. 1953 Jan 31;264(6753):207-8 [13097986] Lancet. 1953 Jan 31;264(6753):208-13 [13097987] Mol Ther. 2006 Jan;13(1):26-41 [16280257] Transpl Immunol. 2006 Jan;15(3):199-204 [16431286] Exp Hematol. 2006 Feb;34(2):132-9 [16459181] Exp Hematol. 2006 Mar;34(3):369-81 [16543071] Nat Med. 2006 Apr;12(4):401-9 [16582916] Blood. 2006 Nov 15;108(10):3313-20 [16868255] Biol Blood Marrow Transplant. 2000;6(5A):548-54 [11071260] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Blunted rostral anterior cingulate response during a simplified decoding task of negative emotional facial expressions in alcoholic patients. AN - 68217566; 17624997 AB - Alcoholism is characterized by deficits in emotional functioning as well as by deficits in cognitive functioning. However, most brain imaging research on alcoholism has focused on cognition rather than emotion. We used an event-related functional magnetic imaging approach to examine alcoholics' brain blood oxygenation level dependent (BOLD) response to evaluation of emotional stimuli and to compare their response to that of nonalcoholic controls. The task used was a simplified variant of a facial emotion-decoding task in which subjects determined the intensity level of a target emotion displayed as a facial expression. Facial expressions of happy, sad, anger, disgust, and fear were used as stimuli. Alcoholics and controls did not differ in accurately identifying the intensity level on the simple emotional decoding task but there were significant differences in their BOLD response during evaluation of facial emotion. In general, alcoholics showed less brain activation than nonalcoholic controls. The greatest differences in activation were during decoding of facial expressions of fear and disgust during which alcoholics had significantly less activation than controls in the affective division of the anterior cingulate cortex (ACC). Alcoholics also had significantly less activation than controls in the affective division of the ACC, while viewing sad faces. Only to facial expressions of anger did the alcoholics show significant activation in the affective ACC and in this case, their BOLD response did not significantly differ from that of the controls. Alcoholics show a deficit in the function of the affective division of the ACC during evaluation of negative facial emotions that can serve as cues for flight or avoidance. This deficit may underlie some of the behavioral dysfunction in alcoholism. JF - Alcoholism, clinical and experimental research AU - Salloum, Jasmin B AU - Ramchandani, Vijay A AU - Bodurka, Jerzy AU - Rawlings, Robert AU - Momenan, Reza AU - George, David AU - Hommer, Daniel W AD - Laboratory of Clinical and Translational Studies, NIAAA, NIH, Bethesda, Maryland, USA. jasmins@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 1490 EP - 1504 VL - 31 IS - 9 SN - 0145-6008, 0145-6008 KW - Central Nervous System Depressants KW - 0 KW - Ethanol KW - 3K9958V90M KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Ethanol -- pharmacology KW - Oxygen -- metabolism KW - Humans KW - Interpersonal Relations KW - Central Nervous System Depressants -- pharmacology KW - Evoked Potentials KW - Adult KW - Case-Control Studies KW - Middle Aged KW - Affect KW - Expressed Emotion KW - Behavior -- physiology KW - Male KW - Visual Perception -- physiology KW - Facial Expression KW - Emotions KW - Gyrus Cinguli -- physiopathology KW - Alcoholism -- physiopathology KW - Visual Perception -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68217566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Blunted+rostral+anterior+cingulate+response+during+a+simplified+decoding+task+of+negative+emotional+facial+expressions+in+alcoholic+patients.&rft.au=Salloum%2C+Jasmin+B%3BRamchandani%2C+Vijay+A%3BBodurka%2C+Jerzy%3BRawlings%2C+Robert%3BMomenan%2C+Reza%3BGeorge%2C+David%3BHommer%2C+Daniel+W&rft.aulast=Salloum&rft.aufirst=Jasmin&rft.date=2007-09-01&rft.volume=31&rft.issue=9&rft.spage=1490&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-16 N1 - Date created - 2007-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Developmental exposure to diethylstilbestrol alters uterine gene expression that may be associated with uterine neoplasia later in life. AN - 68208986; 17394237 AB - Previously, we described a mouse model where the well-known reproductive carcinogen with estrogenic activity, diethylstilbestrol (DES), caused uterine adenocarcinoma following neonatal treatment. Tumor incidence was dose-dependent reaching >90% by 18 mo following neonatal treatment with 1000 microg/kg/d of DES. These tumors followed the initiation/promotion model of hormonal carcinogenesis with developmental exposure as initiator, and exposure to ovarian hormones at puberty as the promoter. To identify molecular pathways involved in DES-initiation events, uterine gene expression profiles were examined in prepubertal mice exposed to DES (1, 10, or 1000 microg/kg/d) on days 1-5 and compared to controls. Of more than 20 000 transcripts, approximately 3% were differentially expressed in at least one DES treatment group compared to controls; some transcripts demonstrated dose-responsiveness. Assessment of gene ontology annotation revealed alterations in genes associated with cell growth, differentiation, and adhesion. When expression profiles were compared to published studies of uteri from 5-d-old DES-treated mice, or adult mice treated with 17beta estradiol, similarities were seen suggesting persistent differential expression of estrogen responsive genes following developmental DES exposure. Moreover, several altered genes were identified in human uterine adenocarcinomas. Four altered genes [lactotransferrin (Ltf), transforming growth factor beta inducible (Tgfb1), cyclin D1 (Ccnd1), and secreted frizzled-related protein 4 (Sfrp4)], selected for real-time RT-PCR analysis, correlated well with the directionality of the microarray data. These data suggested altered gene expression profiles observed 2 wk after treatment ceased, were established at the time of developmental exposure and maybe related to the initiation events resulting in carcinogenesis. (c) 2007 Wiley-Liss, Inc. JF - Molecular carcinogenesis AU - Newbold, Retha R AU - Jefferson, Wendy N AU - Grissom, Sherry F AU - Padilla-Banks, Elizabeth AU - Snyder, Ryan J AU - Lobenhofer, Edward K AD - Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, NIEHS, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 783 EP - 796 VL - 46 IS - 9 SN - 0899-1987, 0899-1987 KW - Estradiol KW - 4TI98Z838E KW - Diethylstilbestrol KW - 731DCA35BT KW - Index Medicus KW - Animals KW - Oligonucleotide Array Sequence Analysis KW - Dose-Response Relationship, Drug KW - Estradiol -- pharmacology KW - Mice KW - Models, Biological KW - Pregnancy KW - Animals, Newborn KW - Gene Expression Profiling KW - Maternal-Fetal Exchange KW - Mice, Inbred Strains KW - Time Factors KW - Female KW - Prenatal Exposure Delayed Effects KW - Uterus -- metabolism KW - Gene Expression -- drug effects KW - Uterine Neoplasms -- genetics KW - Adenocarcinoma -- chemically induced KW - Uterine Neoplasms -- chemically induced KW - Diethylstilbestrol -- toxicity KW - Adenocarcinoma -- genetics KW - Uterus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68208986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Developmental+exposure+to+diethylstilbestrol+alters+uterine+gene+expression+that+may+be+associated+with+uterine+neoplasia+later+in+life.&rft.au=Newbold%2C+Retha+R%3BJefferson%2C+Wendy+N%3BGrissom%2C+Sherry+F%3BPadilla-Banks%2C+Elizabeth%3BSnyder%2C+Ryan+J%3BLobenhofer%2C+Edward+K&rft.aulast=Newbold&rft.aufirst=Retha&rft.date=2007-09-01&rft.volume=46&rft.issue=9&rft.spage=783&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=08991987&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-13 N1 - Date created - 2007-08-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Endocrinol. 2006 Jul;20(7):1535-46 [16513791] Endocrinology. 2006 Jun;147(6 Suppl):S11-7 [16690809] Cancer Res. 2003 Jan 1;63(1):6-11 [12517768] J Midwifery Womens Health. 2003 Jan-Feb;48(1):19-29 [12589302] Ann N Y Acad Sci. 2003 Mar;983:161-9 [12724221] J Pediatr Hematol Oncol. 2003 Aug;25(8):635-6 [12902917] Genome Biol. 2003;4(10):R70 [14519205] Mol Endocrinol. 2003 Oct;17(10):2070-83 [12893882] Reprod Toxicol. 2004 May;18(3):399-406 [15082075] Lab Anim Sci. 1999 Oct;49(5):530-6 [10551455] Mol Cell Endocrinol. 1999 Dec 20;158(1-2):1-5 [10630399] Cancer Res. 2000 Jan 15;60(2):235-7 [10667565] Mol Hum Reprod. 2000 May;6(5):469-73 [10775652] Toxicol Pathol. 2000 Mar-Apr;28(2):237-45 [10805141] FASEB J. 2000 Jun;14(9):1101-8 [10834931] Histol Histopathol. 2001 Jan;16(1):131-40 [11193187] Cancer Res. 2001 Jun 1;61(11):4325-8 [11389053] Dev Biol. 2001 Oct 15;238(2):224-38 [11784006] J Mol Endocrinol. 2002 Jun;28(3):213-23 [12063187] Nucleic Acids Res. 2002 Aug 15;30(16):e86 [12177314] Exp Biol Med (Maywood). 2002 Oct;227(9):709-23 [12324652] Nucleic Acids Res. 2001 May 1;29(9):e45 [11328886] Cancer Causes Control. 2002 Oct;13(8):753-8 [12420954] Toxicol Appl Pharmacol. 2004 Sep 1;199(2):142-50 [15313586] N Engl J Med. 1971 Apr 15;284(15):878-81 [5549830] J Natl Cancer Inst. 1979 Aug;63(2):507-18 [287840] Cancer Res. 1981 Feb;41(2):721-34 [7448817] Cancer Res. 1980 Nov;40(11):3988-99 [7193511] Science. 1981 Jun 19;212(4501):1402-4 [6262919] J Endocrinol. 1981 Nov;91(2):281-7 [7299327] Proc Soc Exp Biol Med. 1986 Jan;181(1):59-65 [3945625] Exp Mol Pathol. 1988 Feb;48(1):59-76 [3335252] Acta Anat (Basel). 1987;130(4):351-8 [3434191] Endocrinology. 1988 Jun;122(6):2355-63 [3286224] Mol Endocrinol. 1988 Sep;2(9):816-24 [3173352] Toxicology. 1988 Oct;51(2-3):201-12 [3176028] J Steroid Biochem. 1989 Mar;32(3):339-43 [2784840] J Biol Chem. 1989 Oct 5;264(28):16941-7 [2674144] Cancer Res. 1990 Dec 1;50(23):7677-81 [2174729] Mol Endocrinol. 1990 Jul;4(7):1041-50 [2126598] In Vitro Cell Dev Biol. 1992 May;28A(5):327-36 [1597405] J Natl Cancer Inst. 1993 Oct 6;85(19):1558-70 [8411230] Environ Health Perspect. 1993 Oct;101(5):378-84 [8080506] Cell Growth Differ. 1994 Jun;5(6):595-606 [8086337] Ann Intern Med. 1995 May 15;122(10):778-88 [7717601] Cancer. 1996 Feb 1;77(3):507-13 [8630958] Exp Clin Endocrinol Diabetes. 1996;104(2):111-22 [8740934] Anat Rec. 1996 Jul;245(3):459-71 [8800404] Biol Reprod. 1997 May;56(5):1147-57 [9160713] Cancer Res. 1997 Oct 1;57(19):4356-9 [9331098] Carcinogenesis. 1997 Dec;18(12):2293-8 [9450472] Dev Biol. 1998 May 15;197(2):141-54 [9630742] Toxicol Pathol. 1999 May-Jun;27(3):325-33 [10356709] Hum Mol Genet. 2005 Apr 15;14 Spec No 1:R149-55 [15809267] BMC Bioinformatics. 2005;6:168 [15998470] Bioinformatics. 2006 May 1;22(9):1111-21 [16522673] Mol Endocrinol. 2005 Mar;19(3):669-82 [15591538] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fibroblast growth factor receptor-1 is required for long-term potentiation, memory consolidation, and neurogenesis. AN - 68200980; 17239352 AB - Although substantial evidence supports the view that adult neurogenesis is involved in learning and memory, how newly generated neurons contribute to the cognitive process remains unknown. Fibroblast growth factor 2 (FGF-2) is known to stimulate the proliferation of neuronal progenitor cells (NPCs) in adult brain. Using conditional knockout mice that lack brain expression of FGFR1, a major receptor for FGF-2, we have investigated the role of adult neurogenesis in hippocampal synaptic plasticity and learning and memory. The Fgfr1 conditional knockout mice were generated by crossing the Fgfr1-null line, the Fgfr1-flox line, and the Nestin-Cre transgenic mice. Bromodeoxyuridine (BrdU) labeling, slice electrophysiology, and Morris Water Maze experiments were performed with the Fgfr1 conditional mutant mice. Bromodeoxyuridine labeling experiments demonstrate that FGFR1 is required for the proliferation of NPCs as well as generation of new neurons in the adult dentate gyrus (DG). Moreover, deficits in neurogenesis in Fgfr1 mutant mice are accompanied by a severe impairment of long-term potentiation (LTP) at the medial perforant path (MPP)-granule neuron synapses in the hippocampal dentate. Moreover, the Fgfr1 mutant mice exhibit significant deficits in memory consolidation but not spatial learning. Our study suggests a critical role of FGFR1 in adult neurogenesis in vivo, provides a potential link between proliferative neurogenesis and dentate LTP, and raises the possibility that adult neurogenesis might contribute to memory consolidation. JF - Biological psychiatry AU - Zhao, Mingrui AU - Li, Dan AU - Shimazu, Kazuhiro AU - Zhou, Yong-Xing AU - Lu, Bai AU - Deng, Chu-Xia AD - Section on Neural Development and Plasticity, Laboratory of Cellular & Synaptic Neurophysiology, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA. Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - 381 EP - 390 VL - 62 IS - 5 SN - 0006-3223, 0006-3223 KW - Glial Fibrillary Acidic Protein KW - 0 KW - Intermediate Filament Proteins KW - NES protein, human KW - Nerve Tissue Proteins KW - Nes protein, mouse KW - Nestin KW - Fgfr1 protein, mouse KW - EC 2.7.10.1 KW - Receptor, Fibroblast Growth Factor, Type 1 KW - Phosphopyruvate Hydratase KW - EC 4.2.1.11 KW - Bromodeoxyuridine KW - G34N38R2N1 KW - Index Medicus KW - Patch-Clamp Techniques -- methods KW - Animals KW - Electric Stimulation -- methods KW - Cell Count KW - Maze Learning -- physiology KW - Medial Forebrain Bundle -- physiology KW - Glial Fibrillary Acidic Protein -- metabolism KW - Mice KW - Dose-Response Relationship, Radiation KW - Nerve Tissue Proteins -- genetics KW - Mice, Transgenic KW - Reaction Time -- physiology KW - Behavior, Animal KW - Reaction Time -- radiation effects KW - Medial Forebrain Bundle -- radiation effects KW - Intermediate Filament Proteins -- genetics KW - Phosphopyruvate Hydratase -- metabolism KW - Hippocampus -- cytology KW - In Vitro Techniques KW - Mutation KW - Bromodeoxyuridine -- metabolism KW - Long-Term Potentiation -- genetics KW - Receptor, Fibroblast Growth Factor, Type 1 -- deficiency KW - Long-Term Potentiation -- physiology KW - Neurons -- physiology KW - Memory -- physiology KW - Receptor, Fibroblast Growth Factor, Type 1 -- physiology KW - Cell Proliferation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68200980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Fibroblast+growth+factor+receptor-1+is+required+for+long-term+potentiation%2C+memory+consolidation%2C+and+neurogenesis.&rft.au=Zhao%2C+Mingrui%3BLi%2C+Dan%3BShimazu%2C+Kazuhiro%3BZhou%2C+Yong-Xing%3BLu%2C+Bai%3BDeng%2C+Chu-Xia&rft.aulast=Zhao&rft.aufirst=Mingrui&rft.date=2007-09-01&rft.volume=62&rft.issue=5&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-26 N1 - Date created - 2007-08-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons. AN - 68200157; 17626162 AB - Under normal conditions, the proline-directed serine/threonine residues of neurofilament tail-domain repeats are exclusively phosphorylated in axons. In pathological conditions such as amyotrophic lateral sclerosis (ALS), motor neurons contain abnormal perikaryal accumulations of phosphorylated neurofilament proteins. The precise mechanisms for this compartment-specific phosphorylation of neurofilaments are not completely understood. Although localization of kinases and phosphatases is certainly implicated, another possibility involves Pin1 modulation of phosphorylation of the proline-directed serine/threonine residues. Pin1, a prolyl isomerase, selectively binds to phosphorylated proline-directed serine/threonine residues in target proteins and isomerizes cis isomers to more stable trans configurations. In this study we show that Pin1 associates with phosphorylated neurofilament-H (p-NF-H) in neurons and is colocalized in ALS-affected spinal cord neuronal inclusions. To mimic the pathology of neurodegeneration, we studied glutamate-stressed neurons that displayed increased p-NF-H in perikaryal accumulations that colocalized with Pin1 and led to cell death. Both effects were reduced upon inhibition of Pin1 activity by the use of an inhibitor juglone and down-regulating Pin1 levels through the use of Pin1 small interfering RNA. Thus, isomerization of lys-ser-pro repeat residues that are abundant in NF-H tail domains by Pin1 can regulate NF-H phosphorylation, which suggests that Pin1 inhibition may be an attractive therapeutic target to reduce pathological accumulations of p-NF-H. JF - Molecular biology of the cell AU - Kesavapany, Sashi AU - Patel, Vyomesh AU - Zheng, Ya-Li AU - Pareek, Tej K AU - Bjelogrlic, Mia AU - Albers, Wayne AU - Amin, Niranjana AU - Jaffe, Howard AU - Gutkind, J Silvio AU - Strong, Michael J AU - Grant, Philip AU - Pant, Harish C AD - Cytoskeletal Protein Regulation Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 3645 EP - 3655 VL - 18 IS - 9 SN - 1059-1524, 1059-1524 KW - NIMA-Interacting Peptidylprolyl Isomerase KW - 0 KW - Naphthoquinones KW - Neurofilament Proteins KW - RNA, Small Interfering KW - neurofilament protein H KW - 108688-71-7 KW - Glutamic Acid KW - 3KX376GY7L KW - PIN1 protein, human KW - EC 5.2.1.8 KW - Peptidylprolyl Isomerase KW - juglone KW - W6Q80SK9L6 KW - Index Medicus KW - Animals KW - Protein Transport -- drug effects KW - Humans KW - Naphthoquinones -- pharmacology KW - RNA, Small Interfering -- metabolism KW - Alzheimer Disease -- enzymology KW - Models, Biological KW - Protein Structure, Quaternary KW - Phosphorylation -- drug effects KW - Rats KW - Ganglia, Spinal -- cytology KW - Amyotrophic Lateral Sclerosis -- pathology KW - Amyotrophic Lateral Sclerosis -- enzymology KW - Genes, Dominant KW - Transfection KW - Protein Binding -- drug effects KW - Spinal Cord -- drug effects KW - Apoptosis -- drug effects KW - Spinal Cord -- pathology KW - Alzheimer Disease -- pathology KW - Ganglia, Spinal -- enzymology KW - Peptidylprolyl Isomerase -- antagonists & inhibitors KW - Glutamic Acid -- toxicity KW - Cell Nucleus -- metabolism KW - Neurons -- drug effects KW - Neurons -- enzymology KW - Neurofilament Proteins -- metabolism KW - Cell Nucleus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68200157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+biology+of+the+cell&rft.atitle=Inhibition+of+Pin1+reduces+glutamate-induced+perikaryal+accumulation+of+phosphorylated+neurofilament-H+in+neurons.&rft.au=Kesavapany%2C+Sashi%3BPatel%2C+Vyomesh%3BZheng%2C+Ya-Li%3BPareek%2C+Tej+K%3BBjelogrlic%2C+Mia%3BAlbers%2C+Wayne%3BAmin%2C+Niranjana%3BJaffe%2C+Howard%3BGutkind%2C+J+Silvio%3BStrong%2C+Michael+J%3BGrant%2C+Philip%3BPant%2C+Harish+C&rft.aulast=Kesavapany&rft.aufirst=Sashi&rft.date=2007-09-01&rft.volume=18&rft.issue=9&rft.spage=3645&rft.isbn=&rft.btitle=&rft.title=Molecular+biology+of+the+cell&rft.issn=10591524&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-09 N1 - Date created - 2007-08-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neurobiol Dis. 2004 Nov;17(2):237-49 [15474361] Biochem Biophys Res Commun. 2004 Aug 13;321(1):210-8 [15358237] Proc Natl Acad Sci U S A. 1985 Jun;82(12):4274-6 [3159022] J Neuropathol Exp Neurol. 1986 Jan;45(1):56-64 [3510274] Neurosci Lett. 1986 Mar 14;64(3):253-8 [2421208] J Neurosci. 1987 Nov;7(11):3474-88 [3119789] FEBS Lett. 1988 Jun 6;233(1):181-5 [3384089] Neurosci Lett. 1988 Oct 17;92(3):291-7 [2462197] Acta Neuropathol. 1992;83(3):240-5 [1557955] Brain Res. 1993 Feb 12;603(1):121-4 [7680936] Mol Biol Cell. 1994 Feb;5(2):161-72 [8019002] J Cell Biol. 1994 Aug;126(4):1031-46 [7519617] Biochem J. 1995 Aug 1;309 ( Pt 3):941-9 [7639714] Nature. 1996 Apr 11;380(6574):544-7 [8606777] Biochem Cell Biol. 1995 Sep-Oct;73(9-10):575-92 [8714676] J Cell Sci. 1996 Sep;109 ( Pt 9):2319-29 [8886982] J Neuropathol Exp Neurol. 1997 May;56(5):523-30 [9143265] Biochemistry. 1998 Mar 17;37(11):3931-40 [9521714] Biochemistry. 1998 Nov 17;37(46):16211-24 [9819213] Nature. 1999 Jun 24;399(6738):784-8 [10391244] Biochim Biophys Acta. 2005 Jan 3;1739(2-3):280-97 [15615646] Curr Opin Struct Biol. 2005 Feb;15(1):35-41 [15718131] J Mol Biol. 2005 Apr 8;347(4):827-39 [15769473] Nat Cell Biol. 2005 May;7(5):435-41 [15867923] J Biol Chem. 2006 Feb 17;281(7):4117-25 [16365047] Neuron. 2006 Mar 2;49(5):655-62 [16504941] Neurobiol Aging. 2006 Jul;27(7):918-25 [15950321] Pharmacol Ther. 2006 Jul;111(1):99-113 [16274748] Mol Cell Neurosci. 2006 May-Jun;32(1-2):155-60 [16697218] Biol Bull. 2006 Jun;210(3):318-33 [16801505] J Biol Chem. 2006 Jul 14;281(28):19296-304 [16675464] Sci STKE. 2006 Aug 22;2006(349):pe32 [16926362] J Neurochem. 2006 Sep;98(6):1697-706 [16945100] Acta Neuropathol. 1990;79(4):402-8 [2111074] J Biol Chem. 2001 Jul 6;276(27):25150-6 [11313338] J Biol Chem. 2001 Aug 17;276(33):31163-70 [11333266] FEBS Lett. 2001 Oct 19;507(1):81-7 [11682063] J Biol Chem. 2002 Jan 25;277(4):2381-4 [11723108] Acta Neuropathol. 2002 Jan;103(1):26-35 [11837744] J Neuropathol Exp Neurol. 2002 Jun;61(6):557-64 [12071639] Bioessays. 2003 Feb;25(2):174-81 [12539244] Bioessays. 2003 Apr;25(4):346-55 [12655642] Neurochem Res. 2003 Jul;28(7):1041-7 [12737529] J Biol Chem. 2003 Jun 27;278(26):24026-32 [12695506] Nature. 2003 Jul 31;424(6948):556-61 [12891359] Biochem Pharmacol. 2003 Oct 15;66(8):1619-25 [14555242] Genes Dev. 2003 Nov 15;17(22):2765-76 [14600023] J Cell Sci. 2004 Feb 29;117(Pt 6):933-41 [14762105] J Neurobiol. 2004 Mar;58(4):514-28 [14978728] Trends Biochem Sci. 2004 Apr;29(4):200-9 [15082314] Am J Pathol. 2004 May;164(5):1727-37 [15111319] J Neurosci. 2004 May 5;24(18):4421-31 [15128856] J Mol Biol. 2004 Jun 4;339(3):635-46 [15147846] J Cell Sci. 2000 Feb;113 ( Pt 3):401-7 [10639328] Neuropharmacology. 2000 Feb 14;39(4):621-30 [10728883] Nature. 2000 May 18;405(6784):360-4 [10830966] Mol Cell. 2000 Oct;6(4):873-83 [11090625] Nucleic Acids Res. 2001 Feb 1;29(3):767-73 [11160900] J Neurochem. 2001 Mar;76(5):1315-25 [11238716] J Neurosci. 2001 Jul 1;21(13):4572-81 [11425885] EMBO J. 2004 Aug 18;23(16):3397-407 [15257284] J Biol Chem. 1982 Sep 10;257(17):10467-70 [7202005] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reconstitution of FOXP3+ regulatory T cells (Tregs) after CD25-depleted allotransplantation in elderly patients and association with acute graft-versus-host disease. AN - 68189204; 17478639 AB - Selective depletion (SD) of host-reactive donor T cells from allogeneic stem-cell transplants (SCTs) using an anti-CD25 immunotoxin (IT) is a strategy to prevent acute graft-versus-host disease (aGvHD). There is concern that concurrent removal of regulatory T cells (T(regs)) with incomplete removal of alloactivated CD25(+) T cells could increase the risk of aGvHD. We therefore measured T(regs) in the blood of 16 patients receiving a T-cell-depleted allograft together with anti-CD25-IT-treated SD lymphocytes, in 13 of their HLA-identical donors, and in 10 SD products. T(regs) were characterized by intracellular staining for forkhead box protein 3 (FOXP3) and by quantitative reverse-transcription-polymerase chain reaction (qRT-PCR) for FOXP3 gene in CD4(+) cells. Patients received a median of 1.0 x 10(8)/kg SD T cells and a stem cell product containing a median of 0.25 x 10(4)/kg residual T cells. T(regs) reconstituted promptly after SCT and underwent further expansion. Of the CD4(+) T cells in SD products, 1.5% to 4.8% were CD25(-) T(regs). Acute GvHD (>or= grade II) was restricted to 5 patients whose donors had significantly (P = .019) fewer T(regs) compared with those without clinically significant aGvHD. These results suggest that rapid T(reg) reconstitution can occur following SD allografts, either from CD25(-) T(regs) escaping depletion, or from residual CD25(-) and CD25(+) T(regs) contained in the stem-cell product that expand after transplantation and may confer additional protection against GvHD. JF - Blood AU - Mielke, Stephan AU - Rezvani, Katayoun AU - Savani, Bipin N AU - Nunes, Raquel AU - Yong, Agnes S M AU - Schindler, John AU - Kurlander, Roger AU - Ghetie, Victor AU - Read, Elizabeth J AU - Solomon, Scott R AU - Vitetta, Ellen S AU - Barrett, A John AD - Allotransplantation Section, Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892-1202, USA. mielkes@nhlbi.nih.gov Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - 1689 EP - 1697 VL - 110 IS - 5 SN - 0006-4971, 0006-4971 KW - FOXP3 protein, human KW - 0 KW - Forkhead Transcription Factors KW - Immunotoxins KW - Interleukin-2 Receptor alpha Subunit KW - Abridged Index Medicus KW - Index Medicus KW - Acute Disease KW - Hematopoietic Stem Cells -- immunology KW - Immunotoxins -- immunology KW - Risk Factors KW - Humans KW - Aged KW - Middle Aged KW - Interleukin-2 Receptor alpha Subunit -- immunology KW - Follow-Up Studies KW - Transplantation, Homologous KW - Immunotoxins -- pharmacology KW - Male KW - Female KW - Forkhead Transcription Factors -- immunology KW - Peripheral Blood Stem Cell Transplantation KW - Recovery of Function -- immunology KW - Graft vs Host Disease -- immunology KW - Forkhead Transcription Factors -- biosynthesis KW - Lymphocyte Depletion -- adverse effects KW - Graft vs Host Disease -- blood KW - T-Lymphocytes, Regulatory -- immunology KW - Living Donors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68189204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Reconstitution+of+FOXP3%2B+regulatory+T+cells+%28Tregs%29+after+CD25-depleted+allotransplantation+in+elderly+patients+and+association+with+acute+graft-versus-host+disease.&rft.au=Mielke%2C+Stephan%3BRezvani%2C+Katayoun%3BSavani%2C+Bipin+N%3BNunes%2C+Raquel%3BYong%2C+Agnes+S+M%3BSchindler%2C+John%3BKurlander%2C+Roger%3BGhetie%2C+Victor%3BRead%2C+Elizabeth+J%3BSolomon%2C+Scott+R%3BVitetta%2C+Ellen+S%3BBarrett%2C+A+John&rft.aulast=Mielke&rft.aufirst=Stephan&rft.date=2007-09-01&rft.volume=110&rft.issue=5&rft.spage=1689&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-19 N1 - Date created - 2007-08-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Haematol. 2000 Jun;109(3):644-51 [10886218] Blood. 2004 Dec 1;104(12):3429-36 [15284108] J Immunol. 2000 Nov 1;165(9):4901-9 [11046015] Blood. 2002 Apr 15;99(8):3041-9 [11929798] Blood. 2002 May 1;99(9):3083-8 [11964269] Blood. 2002 May 15;99(10):3493-9 [11986199] Blood. 2002 Jun 15;99(12):4601-9 [12036894] Blood. 2002 Jul 15;100(2):375-82 [12091325] Lancet. 2002 Jul 13;360(9327):130-7 [12126823] J Exp Med. 2002 Aug 5;196(3):389-99 [12163567] Curr Opin Hematol. 2002 Nov;9(6):490-6 [12394170] Cytotherapy. 2002;4(5):395-406 [12473206] Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1180-4 [12531922] Science. 2003 Feb 14;299(5609):1057-61 [12522256] Nat Immunol. 2003 Apr;4(4):330-6 [12612578] Nat Immunol. 2003 Apr;4(4):337-42 [12612581] Neoplasma. 2003;50(4):296-9 [12937844] Nat Med. 2003 Sep;9(9):1144-50 [12925844] Blood. 2003 Sep 15;102(6):2292-9 [12763937] J Clin Invest. 2003 Nov;112(9):1310-2 [14597756] J Clin Invest. 2003 Nov;112(9):1437-43 [14597769] Blood. 2004 Feb 1;103(3):1158-65 [14525783] Biol Blood Marrow Transplant. 2004 Aug;10(8):552-60 [15282533] J Exp Med. 2005 Jun 6;201(11):1793-803 [15939793] Blood. 2005 Aug 1;106(3):1123-9 [15817673] Cytotherapy. 2005;7(2):109-15 [16040390] Blood. 2005 Oct 15;106(8):2903-11 [15972448] Nat Med. 2005 Nov;11(11):1238-43 [16227988] Bone Marrow Transplant. 2006 Feb;37(3):297-305 [16327814] Blood. 2006 Feb 15;107(4):1717-23 [16278306] Bone Marrow Transplant. 2006 Mar;37(6):559-67 [16444279] J Immunol. 2006 Jun 1;176(11):6586-93 [16709816] Blood. 2006 Aug 15;108(4):1291-7 [16627754] Immunol Rev. 2006 Aug;212:8-27 [16903903] Blood. 2006 Sep 15;108(6):1797-808 [16741253] Blood. 2007 Jan 1;109(1):365-73 [16931626] Blood. 2008 Apr 15;111(8):4392-402 [17878399] Blood. 2004 Oct 1;104(7):2187-93 [15172973] Transplantation. 1990 Jul;50(1):1-7 [2142343] N Engl J Med. 1991 Mar 7;324(10):667-74 [1994250] Blood. 1994 Jun 15;83(12):3815-25 [7515723] J Immunol. 1995 Aug 1;155(3):1151-64 [7636184] Bone Marrow Transplant. 1996 May;17(5):793-9 [8733700] Genome Res. 1996 Oct;6(10):986-94 [8908518] J Immunol Methods. 1997 Dec 29;210(2):195-203 [9520302] Br J Haematol. 1999 Oct;107(1):169-75 [10520038] Bone Marrow Transplant. 2000 May;25 Suppl 2:S39-42 [10933186] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of the catalytic metal during polymerization by DNA polymerase lambda. AN - 68177083; 17475573 AB - The incorporation of dNMPs into DNA by polymerases involves a phosphoryl transfer reaction hypothesized to require two divalent metal ions. Here we investigate this hypothesis using as a model human DNA polymerase lambda (Pol lambda), an enzyme suggested to be activated in vivo by manganese. We report the crystal structures of four complexes of human Pol lambda. In a 1.9 A structure of Pol lambda containing a 3'-OH and the non-hydrolyzable analog dUpnpp, a non-catalytic Na+ ion occupies the site for metal A and the ribose of the primer-terminal nucleotide is found in a conformation that positions the acceptor 3'-OH out of line with the alpha-phosphate and the bridging oxygen of the pyrophosphate leaving group. Soaking this crystal in MnCl2 yielded a 2.0 A structure with Mn2+ occupying the site for metal A. In the presence of Mn2+, the conformation of the ribose is C3'-endo and the 3'-oxygen is in line with the leaving oxygen, at a distance from the phosphorus atom of the alpha-phosphate (3.69 A) consistent with and supporting a catalytic mechanism involving two divalent metal ions. Finally, soaking with MnCl2 converted a pre-catalytic Pol lambda/Na+ complex with unreacted dCTP in the active site into a product complex via catalysis in the crystal. These data provide pre- and post-transition state information and outline in a single crystal the pathway for the phosphoryl transfer reaction carried out by DNA polymerases. JF - DNA repair AU - Garcia-Diaz, Miguel AU - Bebenek, Katarzyna AU - Krahn, Joseph M AU - Pedersen, Lars C AU - Kunkel, Thomas A AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - 1333 EP - 1340 VL - 6 IS - 9 SN - 1568-7864, 1568-7864 KW - Phosphates KW - 0 KW - Manganese KW - 42Z2K6ZL8P KW - DNA KW - 9007-49-2 KW - DNA Polymerase beta KW - EC 2.7.7.- KW - DNA polymerase beta2 KW - Index Medicus KW - Phosphates -- metabolism KW - Crystallization KW - Models, Molecular KW - Humans KW - Crystallography, X-Ray KW - Protein Binding KW - Protein Conformation KW - Catalysis KW - Binding Sites KW - Manganese -- pharmacology KW - DNA Polymerase beta -- genetics KW - DNA -- metabolism KW - DNA Polymerase beta -- chemistry KW - DNA -- chemistry KW - DNA Polymerase beta -- metabolism KW - Mutagenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68177083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+repair&rft.atitle=Role+of+the+catalytic+metal+during+polymerization+by+DNA+polymerase+lambda.&rft.au=Garcia-Diaz%2C+Miguel%3BBebenek%2C+Katarzyna%3BKrahn%2C+Joseph+M%3BPedersen%2C+Lars+C%3BKunkel%2C+Thomas+A&rft.aulast=Garcia-Diaz&rft.aufirst=Miguel&rft.date=2007-09-01&rft.volume=6&rft.issue=9&rft.spage=1333&rft.isbn=&rft.btitle=&rft.title=DNA+repair&rft.issn=15687864&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-25 N1 - Date created - 2007-08-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2001 Sep 14;276(37):34659-63 [11457865] Mol Cell. 2005 Aug 5;19(3):357-66 [16061182] Proteins. 2003 Feb 15;50(3):437-50 [12557186] Biochemistry. 2003 Jun 24;42(24):7467-76 [12809503] Biochemistry. 2003 Aug 19;42(32):9564-74 [12911298] J Biol Chem. 2003 Sep 5;278(36):34685-90 [12829698] J Biol Chem. 2004 Jan 2;279(1):805-11 [14561766] Mol Cell. 2004 Feb 27;13(4):561-72 [14992725] Biochemistry. 2004 Jun 1;43(21):6751-62 [15157109] J Biol Chem. 1972 Nov 10;247(21):6784-94 [4343158] J Biol Chem. 1979 Aug 10;254(15):6889-93 [378995] J Biol Chem. 1990 Aug 25;265(24):14327-34 [2201684] EMBO J. 1991 Jan;10(1):25-33 [1989886] Acta Crystallogr A. 1991 Mar 1;47 ( Pt 2):110-9 [2025413] Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):905-21 [9757107] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765] Mol Cell. 2004 Dec 3;16(5):701-13 [15574326] Nat Struct Mol Biol. 2005 Jan;12(1):97-8 [15608652] J Biol Chem. 2005 May 6;280(18):18469-75 [15749700] EMBO J. 2005 Sep 7;24(17):2957-67 [16107880] J Biol Chem. 2005 Sep 9;280(36):31641-7 [16002405] DNA Repair (Amst). 2005 Dec 8;4(12):1358-67 [16213194] Cell. 2006 Jan 27;124(2):331-42 [16439207] Mol Cell. 2006 Apr 7;22(1):5-13 [16600865] Structure. 2006 Apr;14(4):757-66 [16615916] Nucleic Acids Res. 2006;34(11):3259-66 [16807316] Immunity. 2006 Jul;25(1):31-41 [16860755] Radiat Res. 2006 Nov;166(5):693-714 [17067213] Annu Rev Biochem. 2002;71:133-63 [12045093] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cyclooxygenase-2 deficiency exacerbates bleomycin-induced lung dysfunction but not fibrosis. AN - 68174293; 17496151 AB - Cyclooxygenase (COX)-derived eicosanoids have been implicated in the pathogenesis of pulmonary fibrosis. Uncertainty regarding the influence of COX-2 on experimental pulmonary fibrosis prompted us to clarify the fibrotic and functional effects of intratracheal bleomycin administration in mice genetically deficient in COX-2. Further, the effects of airway-specific COX-1 overexpression on fibrotic and functional outcomes in wild-type and COX-2 knockout mice were assessed. Equivalent increases in airway cell influx, lung collagen content, and histopathologic evidence of fibrosis were observed in wild-type and COX-2 knockout mice 21 d after bleomycin treatment, suggesting that COX-2 deficiency did not alter the extent or severity of fibrosis in this model. However, bleomycin-induced alterations in respiratory mechanics were more severe in COX-2 knockout mice than in wild-type mice, as illustrated by a greater decrease in static compliance compared with genotype-matched, saline-treated control mice (26 +/- 3% versus 11 +/- 4% decreases for COX-2 knockout and wild-type mice, respectively; P < 0.05). The influence of COX-1 overexpression in airway Clara cells was also examined. Whereas the fibrotic effects of bleomycin were not altered in wild-type or COX-2 knockout mice overexpressing COX-1, the exaggerated lung function decrement in bleomycin-treated COX-2 knockout mice was prevented by COX-1 overexpression and coincided with decreased airway cysteinyl leukotriene levels. Collectively, these data suggest an important regulatory role for COX-2 in the maintenance of lung function in the setting of lung fibrosis, but not in the progression of the fibrotic process per se. JF - American journal of respiratory cell and molecular biology AU - Card, Jeffrey W AU - Voltz, James W AU - Carey, Michelle A AU - Bradbury, J Alyce AU - Degraff, Laura M AU - Lih, Fred B AU - Bonner, James C AU - Morgan, Daniel L AU - Flake, Gordon P AU - Zeldin, Darryl C AD - Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, NC 27709, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 300 EP - 308 VL - 37 IS - 3 SN - 1044-1549, 1044-1549 KW - Eicosanoids KW - 0 KW - Recombinant Proteins KW - Bleomycin KW - 11056-06-7 KW - Ptgs2 protein, mouse KW - EC 1.14.99.- KW - Cyclooxygenase 1 KW - EC 1.14.99.1 KW - Cyclooxygenase 2 KW - Index Medicus KW - Animals KW - Cyclooxygenase 1 -- metabolism KW - Pulmonary Fibrosis -- etiology KW - Eicosanoids -- metabolism KW - Humans KW - Gene Expression KW - Cyclooxygenase 1 -- genetics KW - Mice KW - Recombinant Proteins -- genetics KW - Mice, Transgenic KW - Pulmonary Fibrosis -- metabolism KW - Mice, Knockout KW - Respiratory Mechanics KW - Recombinant Proteins -- metabolism KW - Pulmonary Fibrosis -- pathology KW - Mice, Inbred C57BL KW - Female KW - Cyclooxygenase 2 -- deficiency KW - Cyclooxygenase 2 -- genetics KW - Lung -- drug effects KW - Bleomycin -- toxicity KW - Lung -- enzymology KW - Lung -- pathology KW - Lung -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68174293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=Cyclooxygenase-2+deficiency+exacerbates+bleomycin-induced+lung+dysfunction+but+not+fibrosis.&rft.au=Card%2C+Jeffrey+W%3BVoltz%2C+James+W%3BCarey%2C+Michelle+A%3BBradbury%2C+J+Alyce%3BDegraff%2C+Laura+M%3BLih%2C+Fred+B%3BBonner%2C+James+C%3BMorgan%2C+Daniel+L%3BFlake%2C+Gordon+P%3BZeldin%2C+Darryl+C&rft.aulast=Schooler&rft.aufirst=Carmi&rft.date=2007-05-01&rft.volume=62B&rft.issue=3&rft.spage=P165&rft.isbn=&rft.btitle=&rft.title=Journals+of+Gerontology+Series+B%3A+Psychological+Sciences+and+Social+Sciences&rft.issn=10795014&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-19 N1 - Date created - 2007-08-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am Rev Respir Dis. 1982 Mar;125(3):290-4 [6279000] Am Rev Respir Dis. 1979 Jul;120(1):67-73 [88916] Respiration. 1987;51(4):256-65 [3116626] J Clin Pathol. 1988 Apr;41(4):467-70 [3366935] J Clin Invest. 1995 Apr;95(4):1861-8 [7706493] Lung. 1996;174(5):315-23 [8843057] J Appl Physiol. 1964 Jan;19:97-104 [14104296] Am J Respir Crit Care Med. 2005 Mar 15;171(6):639-44 [15640368] Clin Sci (Lond). 2005 Jun;108(6):479-91 [15896193] Crit Rev Immunol. 2005;25(6):429-63 [16390322] J Immunol. 2006 Jul 1;177(1):621-30 [16785560] Am J Physiol Lung Cell Mol Physiol. 2006 Aug;291(2):L144-56 [16473862] Pharmacol Rev. 2006 Sep;58(3):375-88 [16968946] J Immunol. 2006 Oct 1;177(7):4785-93 [16982919] Am J Respir Crit Care Med. 2006 Oct 1;174(7):803-9 [16825656] Respir Res. 2006;7:137 [17118201] Circ Res. 2001 Mar 30;88(6):593-9 [11282893] Am J Pathol. 2001 Apr;158(4):1411-22 [11290559] Am J Respir Crit Care Med. 2002 Jan 15;165(2):229-35 [11790660] Am J Respir Cell Mol Biol. 2002 Mar;26(3):277-82 [11867335] Am J Pathol. 2002 Aug;161(2):459-70 [12163371] Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):277-82 [12493843] Crit Care Med. 2003 May;31(5):1442-8 [12771616] Am J Respir Crit Care Med. 2003 Dec 1;168(11):1358-65 [14644925] Circ Res. 2003 Nov 28;93(11):1089-94 [14563714] Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3047-52 [14970333] Am J Pathol. 2004 Nov;165(5):1663-76 [15509536] Prostaglandins. 1986 Nov;32(5):769-80 [3823489] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nuclear receptor corepressor is a novel regulator of phosphatidylinositol 3-kinase signaling. AN - 68171439; 17606624 AB - The nuclear receptor corepressor (NCoR) regulates the activities of DNA-binding transcription factors. Recent observations of its distribution in the extranuclear compartment raised the possibility that it could have other cellular functions in addition to transcription repression. We previously showed that phosphatidylinositol 3-kinase (PI3K) signaling is aberrantly activated by a mutant thyroid hormone beta receptor (TRbetaPV, hereafter referred to as PV) via physical interaction with p85alpha, thus contributing to thyroid carcinogenesis in a mouse model of follicular thyroid carcinoma (TRbetaPV/PV mouse). Since NCoR is known to modulate the actions of TRbeta mutants in vivo and in vitro, we asked whether NCoR regulates PV-activated PI3K signaling. Remarkably, we found that NCoR physically interacted with and competed with PV for binding to the C-terminal SH2 (Src homology 2) domain of p85alpha, the regulatory subunit of PI3K. Confocal fluorescence microscopy showed that both NCoR and p85alpha were localized in the nuclear as well as in the cytoplasmic compartments. Overexpression of NCoR in thyroid tumor cells of TRbetaPV/PV mouse reduced PI3K signaling, as indicated by the decrease in the phosphorylation of its immediate downstream effector, p-AKT. Conversely, lowering cellular NCoR by siRNA knockdown in tumor cells led to overactivated p-AKT and increased cell proliferation and motility. Furthermore, NCoR protein levels were significantly lower in thyroid tumor cells than in wild-type thyrocytes, allowing more effective binding of PV to p85alpha to activate PI3K signaling and thus contributing to tumor progression. Taken together, these results indicate that NCoR, via protein-protein interaction, is a novel regulator of PI3K signaling and could serve to modulate thyroid tumor progression. JF - Molecular and cellular biology AU - Furuya, Fumihiko AU - Guigon, Celine J AU - Zhao, Li AU - Lu, Changxue AU - Hanover, John A AU - Cheng, Sheue-yann AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Dr., Room 5128, Bethesda, MD 20892-4264, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 6116 EP - 6126 VL - 27 IS - 17 SN - 0270-7306, 0270-7306 KW - NCOR1 protein, human KW - 0 KW - Ncor1 protein, mouse KW - Nuclear Proteins KW - Nuclear Receptor Co-Repressor 1 KW - Protein Subunits KW - RNA, Small Interfering KW - Repressor Proteins KW - Thyroid Hormone Receptors beta KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Index Medicus KW - Proto-Oncogene Proteins c-akt -- genetics KW - Animals KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Thyroid Neoplasms KW - Thyroid Gland -- pathology KW - Humans KW - Mice KW - Mice, Transgenic KW - Protein Subunits -- metabolism KW - RNA, Small Interfering -- metabolism KW - Thyroid Gland -- cytology KW - Thyroid Hormone Receptors beta -- metabolism KW - Protein Subunits -- genetics KW - Cells, Cultured KW - Gene Expression Regulation KW - Thyroid Hormone Receptors beta -- genetics KW - Signal Transduction -- physiology KW - Phosphatidylinositol 3-Kinases -- genetics KW - Nuclear Proteins -- genetics KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Repressor Proteins -- metabolism KW - Nuclear Proteins -- metabolism KW - Repressor Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68171439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Nuclear+receptor+corepressor+is+a+novel+regulator+of+phosphatidylinositol+3-kinase+signaling.&rft.au=Furuya%2C+Fumihiko%3BGuigon%2C+Celine+J%3BZhao%2C+Li%3BLu%2C+Changxue%3BHanover%2C+John+A%3BCheng%2C+Sheue-yann&rft.aulast=Furuya&rft.aufirst=Fumihiko&rft.date=2007-09-01&rft.volume=27&rft.issue=17&rft.spage=6116&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-12 N1 - Date created - 2007-08-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13209-14 [11069286] J Clin Invest. 2006 Nov;116(11):2972-84 [17039256] Cell. 2002 Jul 12;110(1):55-67 [12150997] Nature. 2002 Oct 31;419(6910):934-9 [12410313] Thyroid. 2002 Nov;12(11):963-9 [12490073] Endocr J. 2003 Feb;50(1):77-83 [12733712] Trends Endocrinol Metab. 2003 Sep;14(7):327-33 [12946875] Carcinogenesis. 2003 Sep;24(9):1467-79 [12869418] J Med Genet. 2004 Mar;41(3):161-70 [14985374] J Clin Invest. 1991 Dec;88(6):2123-30 [1661299] J Clin Invest. 1993 Oct;92(4):1986-93 [8408652] Nature. 1995 Oct 5;377(6548):397-404 [7566114] Mol Cell Biol. 2005 Jan;25(1):124-35 [15601836] Biochimie. 2005 Mar-Apr;87(3-4):287-97 [15781315] Mol Cell Biol. 2005 Sep;25(17):7687-95 [16107715] Endocrinology. 2005 Oct;146(10):4456-63 [16002527] Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16251-6 [16260719] Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1780-5 [16446424] Thyroid. 2006 Mar;16(3):211-6 [16571082] Oncogene. 2006 May 4;25(19):2736-47 [16314832] Genes Dev. 2006 Jun 1;20(11):1405-28 [16751179] Trends Cell Biol. 2006 Sep;16(9):461-6 [16870447] Cell. 2006 Oct 6;127(1):185-97 [17018285] Nat Rev Mol Cell Biol. 2002 Mar;3(3):207-14 [11994741] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Activation of cellular Arf GTPases by poliovirus protein 3CD correlates with virus replication. AN - 68168407; 17567696 AB - We have previously shown that synthesis of poliovirus protein 3CD in uninfected HeLa cell extracts induces an increased association with membranes of the cellular Arf GTPases, which are key players in cellular membrane traffic. Arfs cycle between an inactive, cytoplasmic, GDP-bound form and an active, membrane-associated, GTP-bound form. 3CD promotes binding of Arf to membranes by initiating recruitment to membranes of guanine nucleotide exchange factors (GEFs), BIG1 and BIG2. GEFs activate Arf by replacing GDP with GTP. In poliovirus-infected cells, there is a dramatic redistribution of cellular Arf pools that coincides with the reorganization of membranes used to form viral RNA replication complexes. Here we demonstrate that Arf translocation in vitro can be induced by purified recombinant 3CD protein; thus, concurrent translation of viral RNA is not required. Coexpression of 3C and 3D proteins was not sufficient to target Arf to membranes. 3CD expressed in HeLa cells was retained after treatment of the cells with digitonin, indicating that it may interact with a membrane-bound host factor. A F441S mutant of 3CD was shown previously to have lost Arf translocation activity and was also defective in attracting the corresponding GEFs to membranes. A series of other mutations were introduced at 3CD residue F441. Mutations that retained Arf translocation activity of 3CD also supported efficient growth of virus, regardless of their effects on 3D polymerase elongation activity. Those that abrogated Arf activation by 3CD generated quasi-infectious RNAs that produced some plaques from which revertants that always restored the Arf activation property of 3CD were rescued. JF - Journal of virology AU - Belov, George A AU - Habbersett, Courtney AU - Franco, David AU - Ehrenfeld, Ellie AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8011, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 9259 EP - 9267 VL - 81 IS - 17 SN - 0022-538X, 0022-538X KW - Viral Proteins KW - 0 KW - Cysteine Endopeptidases KW - EC 3.4.22.- KW - 3C proteases KW - EC 3.4.22.28 KW - ADP-Ribosylation Factors KW - EC 3.6.5.2 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Microscopy, Fluorescence KW - Viral Plaque Assay KW - HeLa Cells KW - Amino Acid Substitution -- genetics KW - Humans KW - Cell Membrane -- chemistry KW - Protein Transport KW - Virus Replication KW - Viral Proteins -- genetics KW - Poliovirus -- growth & development KW - ADP-Ribosylation Factors -- metabolism KW - Cysteine Endopeptidases -- metabolism KW - Poliovirus -- metabolism KW - Poliovirus -- genetics KW - Viral Proteins -- metabolism KW - Cysteine Endopeptidases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68168407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Activation+of+cellular+Arf+GTPases+by+poliovirus+protein+3CD+correlates+with+virus+replication.&rft.au=Belov%2C+George+A%3BHabbersett%2C+Courtney%3BFranco%2C+David%3BEhrenfeld%2C+Ellie&rft.aulast=Belov&rft.aufirst=George&rft.date=2007-09-01&rft.volume=81&rft.issue=17&rft.spage=9259&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-28 N1 - Date created - 2007-08-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 2000 Mar;74(5):2219-26 [10666252] J Virol. 2007 May;81(10):5238-45 [17329336] J Virol. 2000 Nov;74(22):10359-70 [11044080] J Virol. 2001 Sep;75(17):8158-65 [11483761] J Cell Sci. 2001 Oct;114(Pt 19):3413-8 [11682601] J Virol. 2002 Mar;76(5):2529-42 [11836431] Arch Virol. 2002 Apr;147(4):731-44 [12038684] Curr Opin Cell Biol. 2003 Aug;15(4):396-404 [12892779] J Virol. 2003 Nov;77(21):11408-16 [14557626] Virology. 2004 Mar 15;320(2):195-205 [15016543] J Biol Chem. 2004 Mar 26;279(13):12659-67 [14711816] EMBO J. 2004 Sep 1;23(17):3462-71 [15306852] Virology. 1988 Sep;166(1):265-70 [2842953] Science. 1991 Dec 13;254(5038):1647-51 [1661029] J Virol. 1992 Apr;66(4):1985-94 [1312615] J Cell Biol. 1992 Dec;119(5):1097-116 [1447290] EMBO J. 1993 Sep;12(9):3587-98 [8253083] Arch Virol Suppl. 1994;9:159-72 [8032247] J Biol Chem. 1994 Oct 28;269(43):27015-20 [7929442] J Virol. 1994 Nov;68(11):7507-15 [7933134] J Virol. 1995 Jun;69(6):3658-67 [7745714] Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2296-301 [8637866] J Virol. 1997 Jan;71(1):578-85 [8985386] Biochemistry. 1997 Apr 15;36(15):4675-84 [9109679] RNA. 1997 Oct;3(10):1124-34 [9326487] J Mol Biol. 1997 Nov 14;273(5):1032-47 [9367789] J Virol. 1997 Dec;71(12):8962-72 [9371552] J Virol. 1997 Dec;71(12):9054-64 [9371562] J Virol. 1998 Aug;72(8):6456-64 [9658088] Genes Dev. 1998 Aug 1;12(15):2293-304 [9694795] J Cell Biol. 1999 Jul 12;146(1):71-84 [10402461] J Virol. 2005 Mar;79(6):3254-66 [15731220] J Virol. 2005 May;79(10):6358-67 [15858019] J Virol. 2005 Jun;79(11):7207-16 [15890959] Virology. 2005 Jun 20;337(1):18-29 [15914217] Nature. 2005 Dec 1;438(7068):597-604 [16319879] Nat Rev Mol Cell Biol. 2006 May;7(5):347-58 [16633337] J Virol. 2006 Jul;80(13):6637-47 [16775351] Dev Cell. 2006 Aug;11(2):191-201 [16890159] J Virol. 2006 Dec;80(23):11852-60 [17005635] J Virol. 2007 Jan;81(2):558-67 [17079330] Cell Cycle. 2007 Jan 1;6(1):36-8 [17245115] J Virol. 2007 Apr;81(7):3583-96 [17251299] Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2567-72 [10716990] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Vpr cytopathicity independent of G2/M cell cycle arrest in human immunodeficiency virus type 1-infected CD4+ T cells. AN - 68168354; 17553871 AB - The mechanism of CD4(+) T-cell depletion in human immunodeficiency virus type 1 (HIV-1)-infected individuals remains unknown, although mounting evidence suggests that direct viral cytopathicity contributes to this loss. The HIV-1 Vpr accessory protein causes cell death and arrests cells in the G(2)/M phase; however, the molecular mechanism underlying these properties is not clear. Mutation of hydrophobic residues on the surface of its third alpha-helix disrupted Vpr toxicity, G(2)/M arrest induction, nuclear localization, and self-association, implicating this region in multiple Vpr functions. Cytopathicity by virion-delivered mutant Vpr protein correlated with G(2)/M arrest induction but not nuclear localization or self-association. However, infection with whole virus encoding these Vpr mutants did not abrogate HIV-1-induced cell killing. Rather, mutant Vpr proteins that are impaired for G(2)/M block still prevented infected cell proliferation, and this property correlated with the death of infected cells. Chemical agents that inhibit infected cells from entering G(2)/M also did not reduce HIV-1 cytopathicity. Combined, these data implicate Vpr in HIV-1 killing through a mechanism involving inhibiting cell division but not necessarily in G(2)/M. Thus, the hydrophobic region of the third alpha-helix of Vpr is crucial for mediating G(2)/M arrest, nuclear localization, and self-association but dispensable for HIV-1 cytopathicity due to residual cell proliferation blockade mediated by a separate region of the protein. JF - Journal of virology AU - Bolton, Diane L AU - Lenardo, Michael J AD - Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg. 10, Rm. 11N311, 10 Center Dr., Bethesda, MD 20892-1892, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 8878 EP - 8890 VL - 81 IS - 17 SN - 0022-538X, 0022-538X KW - Gene Products, vpr KW - 0 KW - vpr Gene Products, Human Immunodeficiency Virus KW - Index Medicus KW - Hydrophobic and Hydrophilic Interactions KW - Protein Structure, Secondary KW - Models, Molecular KW - Humans KW - Jurkat Cells KW - Cell Line, Tumor KW - Mutation, Missense KW - Mutagenesis, Site-Directed KW - Protein Transport -- genetics KW - Amino Acid Substitution -- genetics KW - Cell Death KW - Protein Binding -- genetics KW - CD4-Positive T-Lymphocytes -- cytology KW - HIV-1 -- pathogenicity KW - CD4-Positive T-Lymphocytes -- virology KW - Gene Products, vpr -- chemistry KW - Gene Products, vpr -- physiology KW - Cytopathogenic Effect, Viral KW - Cell Cycle KW - Gene Products, vpr -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68168354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Resistance+to+Chronic+Wasting+Disease+in+Transgenic+Mice+Expressing+a+Naturally+Occurring+Allelic+Variant+of+Deer+Prion+Protein&rft.au=Meade-White%2C+Kimberly%3BRace%2C+Brent%3BTrifilo%2C+Matthew%3BBossers%2C+Alex%3BFavara%2C+Cynthia%3BLacasse%2C+Rachel%3BMiller%2C+Michael%3BWilliams%2C+Elizabeth%3BOldstone%2C+Michael%3BRace%2C+Richard%3BChesebro%2C+Bruce&rft.aulast=Meade-White&rft.aufirst=Kimberly&rft.date=2007-05-01&rft.volume=81&rft.issue=9&rft.spage=4533&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-28 N1 - Date created - 2007-08-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 2005 Mar;79(5):2780-7 [15708996] Microbes Infect. 2000 Jul;2(9):1011-7 [10967282] Virology. 2000 Oct 10;276(1):16-26 [11021990] J Biol Chem. 2000 Oct 13;275(41):32016-26 [10903315] J Virol. 2001 Apr;75(8):3791-801 [11264368] Nat Immunol. 2000 Oct;1(4):285-9 [11017098] Nature. 2001 Apr 19;410(6831):974-9 [11309627] Science. 2001 Nov 2;294(5544):1105-8 [11691994] Sci STKE. 2000 Jun 27;2000(38):pl1 [11752595] J Virol. 2002 May;76(10):5082-93 [11967324] J Virol. 2002 May;76(10):5094-107 [11967325] Arch Virol. 1991;120(3-4):181-92 [1835572] Virology. 1991 Dec;185(2):829-39 [1683728] J Virol. 1993 Nov;67(11):6542-50 [8411357] J Virol. 1993 Dec;67(12):7229-37 [8230445] Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7311-5 [8041786] J Biol Chem. 1994 Dec 23;269(51):32131-7 [7798208] J Virol. 1995 Feb;69(2):882-8 [7815556] Nature. 1995 Jan 12;373(6510):117-22 [7529365] Nature. 1995 Jan 12;373(6510):123-6 [7816094] J Virol. 1995 Apr;69(4):2378-83 [7884883] J Virol. 1995 Oct;69(10):6304-13 [7666531] J Virol. 1995 Nov;69(11):6705-11 [7474080] J Virol. 1995 Nov;69(11):6859-64 [7474100] J Biol Chem. 1995 Oct 27;270(43):25564-9 [7592727] J Virol. 1995 Dec;69(12):7507-18 [7494257] J Virol. 1995 Dec;69(12):7909-16 [7494303] J Virol. 1996 Apr;70(4):2324-31 [8642659] J Virol. 1996 Mar;70(3):1340-54 [8627650] Drug Resist Updat. 2001 Oct;4(5):303-13 [11991684] J Mol Biol. 2003 Mar 14;327(1):215-27 [12614620] Mol Biol Cell. 2004 Apr;15(4):1793-801 [14767062] Cell. 2004 Aug 20;118(4):493-504 [15315761] Science. 2005 Mar 4;307(5714):1465-8 [15746428] Biochem J. 2005 Apr 15;387(Pt 2):333-41 [15571493] Nature. 2005 Apr 28;434(7037):1093-7 [15793563] Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3369-74 [16492778] AIDS. 2006 Apr 4;20(6):831-6 [16549966] Microbes Infect. 2006 Mar;8(3):670-9 [16480911] PLoS Pathog. 2006 Dec;2(12):e127 [17140287] Nat Cell Biol. 1999 May;1(1):60-7 [10559866] J Biol Chem. 2000 Apr 28;275(17):12661-6 [10777558] J Virol. 2000 Jul;74(14):6520-7 [10864665] Exp Cell Res. 2000 Aug 1;258(2):261-9 [10896777] J Exp Med. 2004 Sep 20;200(6):749-59 [15365096] J Biol Chem. 2004 Oct 1;279(40):41801-6 [15294906] J Clin Invest. 1991 May;87(5):1710-5 [2022741] J Mol Biol. 1996 Sep 6;261(5):599-606 [8800208] Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11382-8 [8876144] Biochem Biophys Res Commun. 1997 Mar 17;232(2):550-4 [9125220] J Virol. 1997 May;71(5):3961-71 [9094673] Science. 1997 May 9;276(5314):960-4 [9139661] J Virol. 1997 Jun;71(6):4331-8 [9151821] J Virol. 1997 Jul;71(7):5579-92 [9188632] AIDS. 1997 Aug;11(10):1219-25 [9256939] J Virol. 1997 Sep;71(9):6339-47 [9261351] Cell Biochem Funct. 1997 Sep;15(3):171-9 [9377795] J Virol. 1998 Jan;72(1):660-70 [9420271] Nat Med. 1998 Jan;4(1):65-71 [9427608] Genes Dev. 1998 Jan 15;12(2):175-85 [9436978] Virology. 1998 Jan 20;240(2):232-7 [9454696] J Exp Med. 1998 Feb 2;187(3):403-13 [9449720] EMBO J. 1998 Feb 16;17(4):909-17 [9463369] J Biol Chem. 1998 Apr 3;273(14):8130-6 [9525916] Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5281-6 [9560267] J Virol. 1998 Jun;72(6):4686-93 [9573232] FEBS Lett. 1998 Jul 31;432(1-2):17-20 [9710242] J Virol. 1998 Nov;72(11):8873-83 [9765432] J Mol Biol. 1999 Feb 5;285(5):2105-17 [9925788] J Virol. 1999 Apr;73(4):3236-45 [10074177] Biochem Biophys Res Commun. 1999 May 10;258(2):379-84 [10329395] Annu Rev Immunol. 1999;17:625-56 [10358770] J Virol. 1999 Jul;73(7):5422-30 [10364289] Cancer Res. 1999 Sep 1;59(17):4375-82 [10485486] Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):12039-43 [10518572] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Erythrocebus patas monkey offspring exposed perinatally to NRTIs sustain skeletal muscle mitochondrial compromise at birth and at 1 year of age. AN - 68158514; 17545213 AB - Antiretroviral nucleoside reverse transcriptase inhibitors (NRTIs), given to human immunodeficiency virus-1-infected pregnant women to prevent vertical viral transmission, have caused mitochondrial dysfunction in some human infants. Here, we examined mitochondrial integrity in skeletal muscle from offspring of pregnant retroviral-free Erythrocebus patas dams administered human-equivalent NRTI doses for the last 10 weeks of gestation or for 10 weeks of gestation and 6 weeks after birth. Exposures included no drug, Zidovudine (AZT), Lamivudine (3TC), AZT/3TC, AZT/Didanosine (ddI), and Stavudine (d4T)/3TC. Offspring were examined at birth (n=3 per group) and 1 year (n=4 per group, not including 3TC alone). Circulating levels of creatine kinase were elevated at 1 year in the d4T/3TC-exposed group. Measurement of oxidative phosphorylation enzyme activities (complexes I, II, and IV) revealed minimal NRTI-induced changes at birth and at 1 year. Histochemistry for complex IV activity showed abnormal staining with activity depletion at birth and 1 year in groups exposed to AZT alone and to the 2-NRTI combinations. Electron microscopy of skeletal muscle at birth and 1 year of age showed mild to severe mitochondrial damage in all the NRTI-exposed groups, with 3TC inducing mild damage and the 2-NRTI combinations inducing extensive damage. At birth, mitochondrial DNA (mtDNA) was depleted by approximately 50% in groups exposed to AZT alone and the 2-NRTI combinations. At 1 year, the mtDNA levels had increased but remained significantly below normal. Therefore, skeletal muscle mitochondrial compromise occurs at birth and persists at 1 year of age (46 weeks after the last NRTI exposure) in perinatally exposed young monkeys, suggesting that similar events may occur in NRTI-exposed human infants. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Divi, Rao L AU - Leonard, Sarah L AU - Walker, Brettania L AU - Kuo, Maryanne M AU - Shockley, Marie E AU - St Claire, Marisa C AU - Nagashima, Kunio AU - Harbaugh, Steven W AU - Harbaugh, Jeffrey W AU - Poirier, Miriam C AD - Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, Maryland 20892-4255, USA. divir@exchange.nih.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 203 EP - 213 VL - 99 IS - 1 SN - 1096-6080, 1096-6080 KW - Anti-HIV Agents KW - 0 KW - DNA, Mitochondrial KW - Multienzyme Complexes KW - Reverse Transcriptase Inhibitors KW - Creatine Kinase KW - EC 2.7.3.2 KW - Index Medicus KW - Drug Therapy, Combination KW - Multienzyme Complexes -- metabolism KW - Microscopy, Electron, Transmission KW - Animals, Newborn KW - Animals KW - DNA, Mitochondrial -- drug effects KW - Gestational Age KW - DNA, Mitochondrial -- analysis KW - Creatine Kinase -- metabolism KW - Histocytochemistry KW - Erythrocebus patas KW - Female KW - Pregnancy KW - Maternal Exposure -- adverse effects KW - Anti-HIV Agents -- toxicity KW - Muscle, Skeletal -- ultrastructure KW - Mitochondria, Muscle -- ultrastructure KW - Mitochondria, Muscle -- genetics KW - Reverse Transcriptase Inhibitors -- toxicity KW - Muscle, Skeletal -- enzymology KW - Muscle, Skeletal -- drug effects KW - Mitochondria, Muscle -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68158514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Erythrocebus+patas+monkey+offspring+exposed+perinatally+to+NRTIs+sustain+skeletal+muscle+mitochondrial+compromise+at+birth+and+at+1+year+of+age.&rft.au=Divi%2C+Rao+L%3BLeonard%2C+Sarah+L%3BWalker%2C+Brettania+L%3BKuo%2C+Maryanne+M%3BShockley%2C+Marie+E%3BSt+Claire%2C+Marisa+C%3BNagashima%2C+Kunio%3BHarbaugh%2C+Steven+W%3BHarbaugh%2C+Jeffrey+W%3BPoirier%2C+Miriam+C&rft.aulast=Divi&rft.aufirst=Rao&rft.date=2007-09-01&rft.volume=99&rft.issue=1&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-04 N1 - Date created - 2007-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A review of the interaction among dietary antioxidants and reactive oxygen species. AN - 68156637; 17360173 AB - During normal cellular activities, various processes inside of cells produce reactive oxygen species (ROS). Some of the most common ROS are hydrogen peroxide (H(2)O(2)), superoxide ion (O(2)(-)), and hydroxide radical (OH(-)). These compounds, when present in a high enough concentration, can damage cellular proteins and lipids or form DNA adducts that may promote carcinogenic activity. The purpose of antioxidants in a physiological setting is to prevent ROS concentrations from reaching a high-enough level within a cell that damage may occur. Cellular antioxidants may be enzymatic (catalase, glutathione peroxidase, superoxide dismutase) or nonenzymatic (glutathione, thiols, some vitamins and metals, or phytochemicals such as isoflavones, polyphenols, and flavanoids). Reactive oxygen species are a potential double-edged sword in disease prevention and promotion. Whereas generation of ROS once was viewed as detrimental to the overall health of the organism, advances in research have shown that ROS play crucial roles in normal physiological processes including response to growth factors, the immune response, and apoptotic elimination of damaged cells. Notwithstanding these beneficial functions, aberrant production or regulation of ROS activity has been demonstrated to contribute to the development of some prevalent diseases and conditions, including cancer and cardiovascular disease (CVD). The topic of antioxidant usage and ROS is currently receiving much attention because of studies linking the use of some antioxidants with increased mortality in primarily higher-risk populations and the lack of strong efficacy data for protection against cancer and heart disease, at least in populations with adequate baseline dietary consumption. In normal physiological processes, antioxidants effect signal transduction and regulation of proliferation and the immune response. Reactive oxygen species have been linked to cancer and CVD, and antioxidants have been considered promising therapy for prevention and treatment of these diseases, especially given the tantalizing links observed between diets high in fruits and vegetables (and presumably antioxidants) and decreased risks for cancer. JF - The Journal of nutritional biochemistry AU - Seifried, Harold E AU - Anderson, Darrell E AU - Fisher, Evan I AU - Milner, John A AD - Division of Cancer Prevention, National Cancer Institute, Rockville, MD 20862, USA. hs41s@nih.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 567 EP - 579 VL - 18 IS - 9 SN - 0955-2863, 0955-2863 KW - Antioxidants KW - 0 KW - Reactive Oxygen Species KW - Index Medicus KW - Animals KW - Humans KW - Diet KW - Models, Biological KW - Signal Transduction KW - Reactive Oxygen Species -- metabolism KW - Neoplasms -- drug therapy KW - Antioxidants -- therapeutic use KW - Cardiovascular Diseases -- metabolism KW - Cardiovascular Diseases -- drug therapy KW - Neoplasms -- prevention & control KW - Cardiovascular Diseases -- prevention & control KW - Neoplasms -- metabolism KW - Antioxidants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68156637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nutritional+biochemistry&rft.atitle=A+review+of+the+interaction+among+dietary+antioxidants+and+reactive+oxygen+species.&rft.au=Seifried%2C+Harold+E%3BAnderson%2C+Darrell+E%3BFisher%2C+Evan+I%3BMilner%2C+John+A&rft.aulast=Seifried&rft.aufirst=Harold&rft.date=2007-09-01&rft.volume=18&rft.issue=9&rft.spage=567&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nutritional+biochemistry&rft.issn=09552863&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-27 N1 - Date created - 2007-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The putative tumor suppressor Tsc-22 is downregulated early in chemically induced hepatocarcinogenesis and may be a suppressor of Gadd45b. AN - 68155841; 17533171 AB - Tsc-22 is a novel tumor suppressor gene that represents a new class of transcription factors that has transcriptional repressor activity. We found Tsc-22 downregulation in livers from B6C3F1 mice following treatment for 2 weeks with carcinogenic doses of the antianxiety drug oxazepam (2500 ppm) or the peroxisome proliferator Wyeth-14,643 (500 ppm) but not with two other carcinogens such as o-nitrotoluene or methyleugenol or three noncarcinogens including p-nitrotoluene, eugenol, or acetaminophen. The expression of Tsc-22 was also repressed in B6C3F1 mouse liver tumors that were induced by several chemicals from 2-year carcinogenicity studies as well as in spontaneous liver tumors. To identify potential Tsc-22 target genes in mouse liver, we transfected small interference RNA (SiRNA) designed to inhibit Tsc-22 into murine liver BNL-CL.2 cells. We selected two potential transcriptional targets of Tsc-22, growth arrest and DNA damage-inducible gene 45 beta (Gadd45b) and leucine zipper, putative tumor suppressor 2 (Lzts2) to test based on our previous complementary DNA microarray studies, showing that expression of these cancer-associated genes was increased when Tsc-22 was repressed. SiRNA treatment of BNL-CL.2 cells with Tsc-22 oligonucleotides but not nonspecific oligonucleotides decreased RNA and protein expression of Tsc-22 by 80-90%, while expression of Gadd45b gene, but not Lzts2, was increased over time after an initial decrease. Treatment of these cells with oxazepam for 48 h also resulted in decreased Tsc-22 and increased Gadd45b expression. These data provide evidence that Tsc-22 is a suppressor of Gadd45b expression, which may contribute to an early antiapoptotic response. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Iida, Mari AU - Anna, Colleen H AU - Gaskin, Nicole D AU - Walker, Nigel J AU - Devereux, Theodora R AD - Laboratory of Molecular Carcinogenesis, Toxicology Operations Branch, Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, USA. kotorogzo@yahoo.co.jp Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 43 EP - 50 VL - 99 IS - 1 SN - 1096-6080, 1096-6080 KW - Antigens, Differentiation KW - 0 KW - Carcinogens KW - Gadd45b protein, mouse KW - RNA, Small Interfering KW - Repressor Proteins KW - Tgfb1i4 protein, mouse KW - Transforming Growth Factor beta1 KW - Tumor Suppressor Proteins KW - Oxazepam KW - 6GOW6DWN2A KW - Index Medicus KW - Animals KW - Oligonucleotide Array Sequence Analysis KW - Oxazepam -- pharmacology KW - Tumor Suppressor Proteins -- genetics KW - Liver -- metabolism KW - Cell Line, Tumor KW - Mice KW - Gene Expression Profiling KW - Mice, Inbred Strains KW - Down-Regulation KW - Liver -- drug effects KW - Tumor Suppressor Proteins -- metabolism KW - RNA, Small Interfering -- pharmacology KW - Transforming Growth Factor beta1 -- pharmacology KW - Female KW - Male KW - Liver Neoplasms, Experimental -- genetics KW - Genes, Tumor Suppressor -- drug effects KW - Antigens, Differentiation -- metabolism KW - Repressor Proteins -- metabolism KW - Carcinogens -- toxicity KW - Antigens, Differentiation -- genetics KW - Liver Neoplasms, Experimental -- chemically induced KW - Repressor Proteins -- genetics KW - Repressor Proteins -- antagonists & inhibitors KW - Gene Expression Regulation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68155841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=The+putative+tumor+suppressor+Tsc-22+is+downregulated+early+in+chemically+induced+hepatocarcinogenesis+and+may+be+a+suppressor+of+Gadd45b.&rft.au=Iida%2C+Mari%3BAnna%2C+Colleen+H%3BGaskin%2C+Nicole+D%3BWalker%2C+Nigel+J%3BDevereux%2C+Theodora+R&rft.aulast=Iida&rft.aufirst=Mari&rft.date=2007-09-01&rft.volume=99&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-04 N1 - Date created - 2007-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toward a checklist for exchange and interpretation of data from a toxicology study. AN - 68155237; 17442663 AB - Data from toxicology and toxicogenomics studies are valuable, and can be combined for meta-analysis using public data repositories such as Chemical Effects in Biological Systems Knowledgebase, ArrayExpress, and Gene Expression Omnibus. In order to fully utilize the data for secondary analysis, it is necessary to have a description of the study and good annotation of the accompanying data. This study annotation permits sophisticated cross-study comparison and analysis, and allows data from comparable subjects to be identified and fully understood. The Minimal Information About a Microarray Experiment Standard was proposed to permit deposition and sharing of microarray data. We propose the first step toward an analogous standard for a toxicogenomics/toxicology study, by describing a checklist of information that best practices would suggest be included with the study data. When the information in this checklist is deposited together with the study data, the checklist information helps the public explore the study data in context of time, or identify data from similarly treated subjects, and also explore/identify potential sources of experimental variability. The proposed checklist summarizes useful information to include when sharing study data for publication, deposition into a database, or electronic exchange with collaborators. It is not a description of how to carry out an experiment, but a definition of how to describe an experiment. It is anticipated that once a toxicology checklist is accepted and put into use, then toxicology databases can be configured to require and output these fields, making it straightforward to annotate data for interpretation by others. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Fostel, Jennifer M AU - Burgoon, Lyle AU - Zwickl, Craig AU - Lord, Peter AU - Corton, J Christopher AU - Bushel, Pierre R AU - Cunningham, Michael AU - Fan, Liju AU - Edwards, Stephen W AU - Hester, Susan AU - Stevens, James AU - Tong, Weida AU - Waters, Michael AU - Yang, ChiHae AU - Tennant, Raymond AD - NIEHS, LMIT ITSS Contract, Research Triangle Park, North Carolina 27709-2233, USA. fostel@niehs.nih.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 26 EP - 34 VL - 99 IS - 1 SN - 1096-6080, 1096-6080 KW - Index Medicus KW - Software KW - Animals KW - Oligonucleotide Array Sequence Analysis -- methods KW - Data Display KW - Data Collection KW - Oligonucleotide Array Sequence Analysis -- statistics & numerical data KW - Meta-Analysis as Topic KW - Toxicity Tests -- statistics & numerical data KW - Toxicity Tests -- methods KW - Data Interpretation, Statistical KW - Databases, Genetic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68155237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Toward+a+checklist+for+exchange+and+interpretation+of+data+from+a+toxicology+study.&rft.au=Fostel%2C+Jennifer+M%3BBurgoon%2C+Lyle%3BZwickl%2C+Craig%3BLord%2C+Peter%3BCorton%2C+J+Christopher%3BBushel%2C+Pierre+R%3BCunningham%2C+Michael%3BFan%2C+Liju%3BEdwards%2C+Stephen+W%3BHester%2C+Susan%3BStevens%2C+James%3BTong%2C+Weida%3BWaters%2C+Michael%3BYang%2C+ChiHae%3BTennant%2C+Raymond&rft.aulast=Fostel&rft.aufirst=Jennifer&rft.date=2007-09-01&rft.volume=99&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-04 N1 - Date created - 2007-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Targeting Akt in cancer therapy. AN - 68122231; 17667591 AB - In an effort to improve therapeutic options in cancer, many investigational drugs are being developed to inhibit signaling pathways that promote the survival of cancer cells. The prototypic pathway that promotes cellular survival is the phosphoinositide 3'-kinase/Akt/mammalian target of rapamycin pathway, which is constitutively activated in many types of cancers. Mechanisms for activation of the serine/threonine kinase, Akt, include loss of tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10) function, amplification or mutation of phosphoinositide 3'-kinase, amplification of Akt, activation of growth factor receptors and exposure to carcinogens. Activation of Akt promotes cellular survival as well as resistance to treatment with chemotherapy and/or radiation therapy. Immunohistochemical analyses have shown that Akt is activated in many types of cancers and preneoplastic lesions, and Akt activation is a poor prognostic factor in various cancers. Taken together, these data demonstrate that Akt is a valid target for inhibition. This review will focus on published data using different approaches to inhibit Akt. We will also consider how the complex regulation of the phosphoinositide 3'-kinase/Akt/mammalian target of rapamycin pathway poses practical issues concerning the design of clinical trials, potential toxicities and the likelihood of finding a therapeutic index when targeting such a critical cellular pathway. JF - Anti-cancer drugs AU - LoPiccolo, Jaclyn AU - Granville, Courtney A AU - Gills, Joell J AU - Dennis, Phillip A AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 861 EP - 874 VL - 18 IS - 8 SN - 0959-4973, 0959-4973 KW - Antineoplastic Agents KW - 0 KW - Lipids KW - Peptides KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Index Medicus KW - Animals KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Lipids -- chemistry KW - Adenosine Triphosphate -- antagonists & inhibitors KW - Humans KW - Signal Transduction -- drug effects KW - Lipids -- pharmacology KW - Peptides -- pharmacology KW - Drug Design KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Proto-Oncogene Proteins c-akt -- drug effects KW - Proto-Oncogene Proteins c-akt -- antagonists & inhibitors KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68122231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anti-cancer+drugs&rft.atitle=Targeting+Akt+in+cancer+therapy.&rft.au=LoPiccolo%2C+Jaclyn%3BGranville%2C+Courtney+A%3BGills%2C+Joell+J%3BDennis%2C+Phillip+A&rft.aulast=LoPiccolo&rft.aufirst=Jaclyn&rft.date=2007-09-01&rft.volume=18&rft.issue=8&rft.spage=861&rft.isbn=&rft.btitle=&rft.title=Anti-cancer+drugs&rft.issn=09594973&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-28 N1 - Date created - 2007-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - CYP2D6 polymorphisms and the impact on tamoxifen therapy. AN - 68119728; 17518364 AB - The cytochrome P450 2D6 (CYP2D6) is an enzyme known to metabolize a variety of xenobiotics and drugs. Inter-individual variation in the metabolic capacity of this enzyme has been extensively studied and associations with genotype have been established. Genetic polymorphisms have been grouped as nonfunctional, reduced function, functional, and multiplication alleles phenotypically. Individuals carrying these alleles are presumed to correspond to poor, intermediate, extensive, and ultrarapid metabolizers (UM), respectively. Tamoxifen has been shown to be metabolized by CYP2D6 to the more potent metabolite endoxifen. Poor metabolizers (PM) of tamoxifen have lower levels of endoxifen and poorer clinical outcomes as compared to extensive metabolizers (EM). Here, we will provide an overview of the history and application of CYP2D6 pharmacogenetics, and will discuss the clinical implications of recent developments relating to the involvement of CYP2D6 in tamoxifen treatment. (c) 2007 Wiley-Liss, Inc. and the American Pharmacists Association. JF - Journal of pharmaceutical sciences AU - Beverage, Jacob N AU - Sissung, Tristan M AU - Sion, Amy M AU - Danesi, Romano AU - Figg, William D AD - Clinical Pharmacology Research Core, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Building 10, Room 5A01, Bethesda, Maryland, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 2224 EP - 2231 VL - 96 IS - 9 SN - 0022-3549, 0022-3549 KW - Antineoplastic Agents, Hormonal KW - 0 KW - Tamoxifen KW - 094ZI81Y45 KW - Cytochrome P-450 CYP2D6 KW - EC 1.14.14.1 KW - Index Medicus KW - Phenotype KW - Animals KW - Polymorphism, Genetic KW - Humans KW - Cytochrome P-450 CYP2D6 -- genetics KW - Neoplasms -- drug therapy KW - Neoplasms -- enzymology KW - Tamoxifen -- therapeutic use KW - Tamoxifen -- adverse effects KW - Antineoplastic Agents, Hormonal -- therapeutic use KW - Antineoplastic Agents, Hormonal -- adverse effects KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68119728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pharmaceutical+sciences&rft.atitle=CYP2D6+polymorphisms+and+the+impact+on+tamoxifen+therapy.&rft.au=Beverage%2C+Jacob+N%3BSissung%2C+Tristan+M%3BSion%2C+Amy+M%3BDanesi%2C+Romano%3BFigg%2C+William+D&rft.aulast=Beverage&rft.aufirst=Jacob&rft.date=2007-09-01&rft.volume=96&rft.issue=9&rft.spage=2224&rft.isbn=&rft.btitle=&rft.title=Journal+of+pharmaceutical+sciences&rft.issn=00223549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-27 N1 - Date created - 2007-08-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - New immunotoxins targeting CD123, a stem cell antigen on acute myeloid leukemia cells. AN - 68109906; 17667524 AB - The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. In this study, immunotoxins were developed to target CD123 only, which bypasses the dependence on other subunits to form intact IL-3R. Three anti-CD123 hybridomas (26292, 32701, and 32716) were selected on the basis of their affinity for CD123. Total RNAs were extracted from the 3 anti-CD123 hybridomas and used to clone the fragment of variable region (Fvs). The Fvs were assembled into single chain Fvs and fused to a 38-kd fragment of Pseudomonas exotoxin A to make recombinant immunotoxins. 26292(Fv)-PE38 was found to have the highest cytotoxic activity on the CD123 expressing leukemia cell line TF-1. It bound the cells with a kd of 3.5 nM. Another immunotoxin, 32716(Fv)-PE38, belonging to a different epitope group, had a similar binding ability but was less active, demonstrating the role of epitope selection in immunotoxin action. The cytotoxic activity of 26292(Fv)-PE38 was increased from 200 to about 40 ng/mL by mutating the REDLK sequence at the C terminus to KDEL. 26292(Fv)-PE38-KDEL was specifically cytotoxic to several CD123 expressing cell lines (TF-1, Molm-13, and Molm-14) with good CD123 expression but not to ML-1 or U937 with low or absent expression. In conclusion, 26292(Fv)-PE38-KDEL shows good cytotoxic activity against CD123 expressing cell lines, and merits further development for the possible treatment of acute myeloid leukemia and other CD123 expressing malignancies. JF - Journal of immunotherapy (Hagerstown, Md. : 1997) AU - Du, Xing AU - Ho, Mitchell AU - Pastan, Ira AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 607 EP - 613 VL - 30 IS - 6 SN - 1524-9557, 1524-9557 KW - Antibodies, Monoclonal KW - 0 KW - Bacterial Toxins KW - Exotoxins KW - IL3RA protein, human KW - Immunoglobulin Fragments KW - Immunoglobulin Variable Region KW - Immunotoxins KW - Interleukin-3 Receptor alpha Subunit KW - Receptors, Interleukin-3 KW - Recombinant Fusion Proteins KW - Virulence Factors KW - ADP Ribose Transferases KW - EC 2.4.2.- KW - toxA protein, Pseudomonas aeruginosa KW - EC 2.4.2.31 KW - Index Medicus KW - Acute Disease KW - Antibodies, Monoclonal -- metabolism KW - Humans KW - Immunoglobulin Fragments -- metabolism KW - Cell Line, Tumor KW - Immunoglobulin Fragments -- immunology KW - Antibodies, Monoclonal -- therapeutic use KW - Antibodies, Monoclonal -- immunology KW - ADP Ribose Transferases -- immunology KW - Leukemia, Myeloid -- immunology KW - Virulence Factors -- therapeutic use KW - Interleukin-3 Receptor alpha Subunit -- metabolism KW - Leukemia, Myeloid -- therapy KW - Receptors, Interleukin-3 -- immunology KW - Bacterial Toxins -- immunology KW - Exotoxins -- immunology KW - Immunotoxins -- metabolism KW - Virulence Factors -- immunology KW - ADP Ribose Transferases -- therapeutic use KW - Bacterial Toxins -- metabolism KW - Receptors, Interleukin-3 -- metabolism KW - Virulence Factors -- metabolism KW - Immunotoxins -- immunology KW - Interleukin-3 Receptor alpha Subunit -- immunology KW - Bacterial Toxins -- therapeutic use KW - Leukemia, Myeloid -- metabolism KW - ADP Ribose Transferases -- metabolism KW - Exotoxins -- metabolism KW - Immunotoxins -- therapeutic use KW - Exotoxins -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68109906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.atitle=New+immunotoxins+targeting+CD123%2C+a+stem+cell+antigen+on+acute+myeloid+leukemia+cells.&rft.au=Du%2C+Xing%3BHo%2C+Mitchell%3BPastan%2C+Ira&rft.aulast=Du&rft.aufirst=Xing&rft.date=2007-09-01&rft.volume=30&rft.issue=6&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.issn=15249557&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-24 N1 - Date created - 2007-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of Individual Components of Multiple Behavior Changes: The PREMIER Trial AN - 57223526; 200804832 AB - Objectives: To assess contributions of individual lifestyle changes on systolic blood pressure (SBP) changes. Methods: We examined associations between lifestyle behavior changes and SBP after 6 and 18 months in 782 PREMIER trial participants. Results: In multivariate models omitting weight, predicted SBP reductions ranged from 1/2 to 1 1/2 mm Hg for reduced urinary sodium, improved fitness, and adherence to the DASH diet (except sodium at 18 months). With weight included, only fitness change additionally predicted SBP at 18 months. Conclusions: Several lifestyle behavior changes are important for BP lowering, but are difficult to detect when weight is included in multivariate models. Adapted from the source document. JF - American Journal of Health Behavior AU - Obarzanek, Eva AU - Vollmer, William M AU - Lin, Pao-Hwa AU - Cooper, Lawton S AU - Young, Deborah R AU - Ard, Jamy D AU - Stevens, Victor J AU - Simons-Morton, Denise G AU - Svetkey, Laura P AU - Harsha, David W AU - Elmer, Patricia J AU - Appel, Lawrence J AD - National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Bethesda MD 20892-7936 Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 545 EP - 560 PB - PNG Publications, Star City WV VL - 31 IS - 5 SN - 1087-3244, 1087-3244 KW - blood pressure, nutrition, physical activity, fitness, lifestyle KW - Fitness KW - Physical activity KW - Nutrition KW - Blood pressure KW - Lifestyle KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57223526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Health+Behavior&rft.atitle=Effects+of+Individual+Components+of+Multiple+Behavior+Changes%3A+The+PREMIER+Trial&rft.au=Obarzanek%2C+Eva%3BVollmer%2C+William+M%3BLin%2C+Pao-Hwa%3BCooper%2C+Lawton+S%3BYoung%2C+Deborah+R%3BArd%2C+Jamy+D%3BStevens%2C+Victor+J%3BSimons-Morton%2C+Denise+G%3BSvetkey%2C+Laura+P%3BHarsha%2C+David+W%3BElmer%2C+Patricia+J%3BAppel%2C+Lawrence+J&rft.aulast=Obarzanek&rft.aufirst=Eva&rft.date=2007-09-01&rft.volume=31&rft.issue=5&rft.spage=545&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Health+Behavior&rft.issn=10873244&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-03-04 N1 - Last updated - 2016-09-27 N1 - CODEN - AJHBF6 N1 - SubjectsTermNotLitGenreText - Blood pressure; Physical activity; Fitness; Lifestyle; Nutrition ER - TY - JOUR T1 - Seat Belt Use Among American Indians/Alaska Natives and Non-Hispanic Whites AN - 57089888; 200802022 AB - Background: Accidents (including motor vehicle injuries) are a leading cause of death among American Indians/Alaskan Natives (AI/AN). The purpose of this study was to examine geographic variation and the existence of a seat belt law on seat belt use among AI/AN and non-Hispanic whites (NHW). Methods: Self-reported seat belt behavior data from the 1997 and 2002 Behavioral Risk Factor Surveillance System were analyzed in 2006-2007 and were restricted to AI/AN (n=4310 for 2002, and n=1758 for 1997) and NHW (n=193,6l7 for 2002, and n=108,551 for 1997) aged 18 years and older. Results: Seat belt non-use varied significantly across geographic regions for both AI/AN and NHW. For example, AI/AN living in the Northern Plains (odds ratio [OR]=12.4, 95% confidence interval [CI]=6.5-23.7) and Alaska (OR=10.3, 95%CI=5.3-19.9) had significantly higher seat belt non-use compared to AI/AN living in the West. In addition, compared to those residing in urban areas, those living in rural areas were 60% more likely in NHW and 2.6 times more likely in AI/AN not to wear a seat belt. Both AI/AN and NHW living in states without primary seat belt laws were approximately twice as likely to report seat belt non-use in 2002 as those living in states with primary laws. In states with primary laws enacted between 1997 and 2002, AI/AN experienced greater decline in seat belt non-use than NHW. Conclusions: Seat belt use among AI/AN and NHW varied significantly by region and urban-rural residency in 2002. Primary seat belt laws appear to help reduce regional and racial disparities in seat belt non-use. [Copyright 2007 American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Garcia, Andrea N AU - Patel, Kushang V AU - Guralnik, Jack M AD - Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Gateway Building, Suite 3C-309, 7201 Wisconsin Ave., MSC 9205, Bethesda MD 20892-9205 Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 200 EP - 206 PB - Elsevier Science, New York NY VL - 33 IS - 3 SN - 0749-3797, 0749-3797 KW - American Indian people KW - Users KW - Seatbelts KW - Motor vehicles KW - Law KW - Alaska Native people KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57089888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Seat+Belt+Use+Among+American+Indians%2FAlaska+Natives+and+Non-Hispanic+Whites&rft.au=Garcia%2C+Andrea+N%3BPatel%2C+Kushang+V%3BGuralnik%2C+Jack+M&rft.aulast=Garcia&rft.aufirst=Andrea&rft.date=2007-09-01&rft.volume=33&rft.issue=3&rft.spage=200&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2007.04.032 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-02-04 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Alaska Native people; American Indian people; Motor vehicles; Law; Users; Seatbelts DO - http://dx.doi.org/10.1016/j.amepre.2007.04.032 ER - TY - CPAPER T1 - Cardioprotective Effects of Zileuton 5-Lo Inhibitor, is Mediated by COX-2 via PKC Delta Activation. T2 - 2007 Meeting of the European Life Scientist Organization (ELSO 2007) AN - 39587648; 4722781 JF - 2007 Meeting of the European Life Scientist Organization (ELSO 2007) AU - Kwak, Hyun-Jeong AU - Park, Kyoung-Mi AU - Lee, Seahyoung AU - Lee, Hyung-Hee AU - Yang, Hee-Jun AU - Park, Hyun-Young Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 KW - Deltas KW - Cyclooxygenase-2 KW - Protein kinase C KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39587648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Meeting+of+the+European+Life+Scientist+Organization+%28ELSO+2007%29&rft.atitle=Cardioprotective+Effects+of+Zileuton+5-Lo+Inhibitor%2C+is+Mediated+by+COX-2+via+PKC+Delta+Activation.&rft.au=Kwak%2C+Hyun-Jeong%3BPark%2C+Kyoung-Mi%3BLee%2C+Seahyoung%3BLee%2C+Hyung-Hee%3BYang%2C+Hee-Jun%3BPark%2C+Hyun-Young&rft.aulast=Kwak&rft.aufirst=Hyun-Jeong&rft.date=2007-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Meeting+of+the+European+Life+Scientist+Organization+%28ELSO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.elso.org/index.php?id=elso2007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Religion and substance abuse treatment: individual and program effects AN - 36914553; 3562190 AB - The relationship between personal religiousness and substance abuse treatment outcomes has emerged as an important issue in the public health arena. Using the 'moral community' perspective, a conceptual framework developed by Stark, Kent, and Doyle (1982) to analyze the contextual effects of religion, we explore the degree to which religion influences two drug treatment outcome measures-critical retention and commitment to treatment. The data are derived from the Drug Abuse Treatment Outcome Studies (DATOS), a national study of 10,010 clients enrolled in 70 drug treatment programs. Three research questions were addressed: (1) What is the relationship between an individual's level of religiosity and retention in treatment and commitment to treatment? (2) How does the ecological context of treatment programs shape the individual-level relationships? (3) To what extent are program practices and characteristics directly linked to outcome level? The findings are supportive of the literature that shows a weak to moderate relationship between religiosity and treatment outcomes. However, the findings did not show strong support for the 'moral community' hypothesis. Although there was a wide variation in the size of the individual-level religiosity-treatment correlations, the variation could not be conclusively attributed to the overall religious emphasis of the programs. The findings suggest that further research is needed in order to understand fully the role of religion in substance abuse treatment. Reprinted by permission of Society for the Scientific Study of Religion JF - Journal for the scientific study of religion AU - Shields, Joseph J AU - Broome, Kirk M AU - Delany, Peter J AU - Fletcher, Bennett W AU - Flynn, Patrick M AD - Catholic University of America ; Texas Christian University ; National Institutes of Health Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 355 EP - 372 VL - 46 IS - 3 SN - 0021-8294, 0021-8294 KW - Sociology KW - Dependency rehabilitation KW - Religiosity KW - Drug addiction KW - Sociological methodology KW - Science KW - Substance abuse KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36914553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+for+the+scientific+study+of+religion&rft.atitle=Religion+and+substance+abuse+treatment%3A+individual+and+program+effects&rft.au=Shields%2C+Joseph+J%3BBroome%2C+Kirk+M%3BDelany%2C+Peter+J%3BFletcher%2C+Bennett+W%3BFlynn%2C+Patrick+M&rft.aulast=Shields&rft.aufirst=Joseph&rft.date=2007-09-01&rft.volume=46&rft.issue=3&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Journal+for+the+scientific+study+of+religion&rft.issn=00218294&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 11325; 12356 12357; 10766 12024 10762; 10449 5772; 3744 561 6220; 3432 12356 12357; 12001 7994 ER - TY - JOUR T1 - Embryonic stem cell patents and human dignity AN - 36894554; 3545991 AB - This article examines the assertion that human embryonic stem cells patents are immoral because they violate human dignity. After analyzing the concept of human dignity and its role in bioethics debates, this article argues that patents on human embryos or totipotent embryonic stem cells violate human dignity, but that patents on pluripotent or multipotent stem cells do not. Since patents on pluripotent or multipotent stem cells may still threaten human dignity by encouraging people to treat embryos as property, patent agencies should carefully monitor and control these patents to ensure that patents are not inadvertently awarded on embryos or totipotent stem cells. Reprinted by permission of Springer JF - Health care analysis AU - Resnik, D B AD - National Institutes of Health, USA Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 211 EP - 222 VL - 15 IS - 3 SN - 1065-3058, 1065-3058 KW - Political Science KW - Morality KW - Patents KW - Foetus KW - Bioethics KW - Health policy KW - Policy studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36894554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+care+analysis&rft.atitle=Embryonic+stem+cell+patents+and+human+dignity&rft.au=Resnik%2C+D+B&rft.aulast=Resnik&rft.aufirst=D&rft.date=2007-09-01&rft.volume=15&rft.issue=3&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Health+care+analysis&rft.issn=10653058&rft_id=info:doi/10.1007%2Fs10728-007-0045-9 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5080 11574; 8281 6085; 9266; 1603 4408 8282 8281 6085; 5788 11888 10472; 9628 DO - http://dx.doi.org/10.1007/s10728-007-0045-9 ER - TY - JOUR T1 - Mark tests for mirror self-recognition in Capuchin monkeys (Cebus apella) trained to touch marks AN - 36864854; 3534430 AB - In Experiment 1, three capuchin monkeys (Cebus apella) were exposed to a mirror in their home cage for 3 days and then given food treats for touching orange marks located on the surface of an experimental chamber. Following training, a mirror was added to the chamber to see if the monkeys would use it to guide non-reinforced contacts with an orange mark on their foreheads that was only visible as a mirror reflection (mark test). Two monkeys touched the head-mark more often with the mirror present than absent, but no mark touches were emitted while looking at the mirror. In Experiment 2, the monkeys were rewarded for touching orange marks on their bodies that were directly visible, followed by another head-mark test. Again, two monkeys touched the mark more often with the mirror present than absent, but these contacts were not emitted while looking at the mirror. Since facing the mirror while mark touching was not required for reinforcement during training, Experiment 3 further tested the possibility that increased mark touching in the presence of the mirror during Experiments 1 and 2 was the result of a memorial process. For this, a final, novel mark test was conducted using an orange mark on the neck that was only visible as a reflection (Experiment 3). No monkeys passed this test. These are the first mark tests given to capuchin monkeys. The results are consistent with the finding that no monkey species is capable of spontaneous mirror self-recognition. The implications of sequential training and mark testing for comparative evaluations of mirror self-recognition capacity are discussed. Copyright John Wiley & Sons. Reproduced with permission. An electronic version of this article is available online at http://www.interscience.wiley.com JF - American journal of primatology AU - Roma, Peter G AU - Silberberg, Alan AU - Huntsberry, Mary E AU - Christensen, Chesley J AU - Ruggiero, Angela M AU - Suomi, Stephen J AD - American University Washington DC ; National Institute of Child Health and Human Development, Poolesville Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 989 EP - 1000 VL - 69 IS - 9 SN - 0275-2565, 0275-2565 KW - Anthropology KW - Capuchin monkeys KW - Experiments KW - Intelligence KW - Physical anthropology KW - Primatology KW - Training KW - Self KW - Primates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36864854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+primatology&rft.atitle=Mark+tests+for+mirror+self-recognition+in+Capuchin+monkeys+%28Cebus+apella%29+trained+to+touch+marks&rft.au=Roma%2C+Peter+G%3BSilberberg%2C+Alan%3BHuntsberry%2C+Mary+E%3BChristensen%2C+Chesley+J%3BRuggiero%2C+Angela+M%3BSuomi%2C+Stephen+J&rft.aulast=Roma&rft.aufirst=Peter&rft.date=2007-09-01&rft.volume=69&rft.issue=9&rft.spage=989&rft.isbn=&rft.btitle=&rft.title=American+journal+of+primatology&rft.issn=02752565&rft_id=info:doi/10.1002%2Fajp.20404 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 9507 1077; 11442 6191; 6608 6085; 12894; 4636 6845 6564 12622; 10148; 10149 DO - http://dx.doi.org/10.1002/ajp.20404 ER - TY - JOUR T1 - Improving Healthcare Accessibility through Point-of-Care Technologies AN - 214004368; 17660275 AB - The NIH is committed to improving healthcare quality in the US and has set up initiatives to address problems such as the fragmented nature of healthcare provision. A hypothesis has been developed that testing closer to the point at which care is delivered may reduce fragmentation of care and improve outcomes. The National Institute of Biomedical Imaging and Bioengineering (NIBIB), the NIH's National Heart, Lung, and Blood Institute, and the National Science Foundation sponsored a workshop, "Improving Health Care Accessibility through Point-of-Care Technologies," in April 2006. The workshop assessed the clinical needs and opportunities for point-of-care (POC) technologies in primary care, the home, and emergency medical services and reviewed minimally invasive and noninvasive testing, including imaging, and conventional testing based on sensor and lab-on-a-chip technologies. Emerging needs of informatics and telehealth and healthcare systems engineering were considered in the POC testing context. Additionally, implications of evidence-based decision-making were reviewed, particularly as it related to the challenges in producing reliable evidence, undertaking regulation, implementing evidence responsibly, and integrating evidence into health policy. Many testing procedures were considered to be valuable in the clinical settings discussed. Technological solutions were proposed to meet these needs, as well as the practical requirements around clinical process change and regulation. From these considerations, a series of recommendations was formulated for development of POC technologies based on input from the symposium attendees. NIBIB has developed a funding initiative to establish a Point-of-Care Technologies Research Network that will work to bridge the technology/clinical gap and provide the partnerships necessary for the application of technologies to pressing clinical needs in POC testing. JF - Clinical Chemistry AU - Price, Christopher P AU - Kricka, Larry J Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 1665 EP - 75 CY - Washington PB - American Association for Clinical Chemistry VL - 53 IS - 9 SN - 00099147 KW - Medical Sciences KW - Health care KW - Emergency medical care KW - Hospitals KW - Quality of care KW - Personal health KW - Family physicians KW - Technological change KW - Risk assessment KW - Research methodology KW - Neurological disorders KW - Multiple sclerosis KW - Heart failure KW - Health services KW - Families & family life KW - Clinical trials KW - Blood pressure KW - Primary care KW - United States KW - Biomedical Technology -- trends KW - Evidence-Based Medicine KW - Telemedicine -- trends KW - Humans KW - Computational Biology -- trends KW - Clinical Laboratory Techniques KW - National Institutes of Health (U.S.) KW - Point-of-Care Systems -- organization & administration KW - Diagnostic Techniques & Procedures KW - Health Services Accessibility UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/214004368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Clinical+Chemistry&rft.atitle=Improving+Healthcare+Accessibility+through+Point-of-Care+Technologies&rft.au=Price%2C+Christopher+P%3BKricka%2C+Larry+J&rft.aulast=Price&rft.aufirst=Christopher&rft.date=2007-09-01&rft.volume=53&rft.issue=9&rft.spage=1665&rft.isbn=&rft.btitle=&rft.title=Clinical+Chemistry&rft.issn=00099147&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Association for Clinical Chemistry Sep 2007 N1 - Document feature - Tables; Diagrams; References N1 - Last updated - 2016-12-03 ER - TY - JOUR T1 - Medication Adherence and Sexual Risk Behavior among HIV-Infected Adults: Implications for Transmission of Resistant Virus AN - 211250998; 17243012 AB - As more people are living long-term with HIV there are growing concerns about specific behaviors that can affect both personal and the public health. This study examined the relationship between antiretroviral therapy (ART) adherence and sexual risk behavior and their association with psychosocial and health factors among a diverse sample of 2,849 HIV-infected adults. Only 8.5% of the sample reported both non-adherence and sexual risk. Individuals were 46% more likely to report one of these risk outcomes when the other one was present and the presence of both outcomes was associated with an increased likelihood of having a detectable viral load. A simultaneous polytomous regression analysis revealed complex relationships among a range of psychosocial variables and the two primary behavioral risk outcomes. There is a need for targeted interventions and integration of mental health and substance use services into primary HIV care settings. [PUBLICATION ABSTRACT] JF - AIDS and Behavior AU - Remien, Robert H AU - Exner, Theresa M AU - Morin, Stephen F AU - Ehrhardt, Anke A AU - Johnson, Mallory O AU - Correale, Jackie AU - Marhefka, Stephanie AU - Kirshenbaum, Sheri B AU - Weinhardt, Lance S AU - Rotheram-Borus, Mary Jane AU - Catz, Sheryl L AU - Gore-Felton, Cheryl AU - Chesney, Margaret A Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 663 EP - 75 CY - New York PB - Springer Science & Business Media VL - 11 IS - 5 SN - 10907165 KW - Psychology KW - Anti-Retroviral Agents KW - Depressive Disorder -- epidemiology KW - Questionnaires KW - Alcoholism -- epidemiology KW - Humans KW - Anxiety Disorders -- diagnosis KW - Adult KW - Depressive Disorder -- diagnosis KW - Social Support KW - Anxiety Disorders -- epidemiology KW - Male KW - Female KW - Sexual Behavior KW - Patient Compliance -- statistics & numerical data KW - Drug Resistance, Viral KW - Risk-Taking KW - HIV Infections -- transmission KW - HIV Infections -- drug therapy KW - HIV Infections -- epidemiology KW - Anti-Retroviral Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/211250998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acriminaljusticeperiodicals&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=Medication+Adherence+and+Sexual+Risk+Behavior+among+HIV-Infected+Adults%3A+Implications+for+Transmission+of+Resistant+Virus&rft.au=Remien%2C+Robert+H%3BExner%2C+Theresa+M%3BMorin%2C+Stephen+F%3BEhrhardt%2C+Anke+A%3BJohnson%2C+Mallory+O%3BCorreale%2C+Jackie%3BMarhefka%2C+Stephanie%3BKirshenbaum%2C+Sheri+B%3BWeinhardt%2C+Lance+S%3BRotheram-Borus%2C+Mary+Jane%3BCatz%2C+Sheryl+L%3BGore-Felton%2C+Cheryl%3BChesney%2C+Margaret+A&rft.aulast=Remien&rft.aufirst=Robert&rft.date=2007-09-01&rft.volume=11&rft.issue=5&rft.spage=663&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-006-9201-8 LA - English DB - ProQuest Central N1 - Copyright - Springer Science+Business Media, LLC 2007 N1 - Last updated - 2014-08-30 N1 - CODEN - AIBEFC DO - http://dx.doi.org/10.1007/s10461-006-9201-8 ER - TY - JOUR T1 - Lung Cancer and History of Pulmonary Tuberculosis among the U.S. Elderly AN - 21120831; 9271141 JF - Annals of Epidemiology AU - Yu, Y AU - Pfeiffer, R AU - Engels, E A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 741 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 17 IS - 9 SN - 1047-2797, 1047-2797 KW - Microbiology Abstracts B: Bacteriology KW - Mycobacterium KW - Geriatrics KW - Tuberculosis KW - Lung cancer KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21120831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Lung+Cancer+and+History+of+Pulmonary+Tuberculosis+among+the+U.S.+Elderly&rft.au=Yu%2C+Y%3BPfeiffer%2C+R%3BEngels%2C+E+A&rft.aulast=Yu&rft.aufirst=Y&rft.date=2007-09-01&rft.volume=17&rft.issue=9&rft.spage=741&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Geriatrics; Tuberculosis; Lung cancer; Mycobacterium ER - TY - JOUR T1 - Helicobacter pylori VacA Enhances Prostaglandin E sub(2) Production through Induction of Cyclooxygenase 2 Expression via a p38 Mitogen-Activated Protein Kinase/Activating Transcription Factor 2 Cascade in AZ-521 Cells AN - 21009214; 7557099 AB - Treatment of AZ-521 cells with Helicobacter pylori VacA increased cyclooxygenase 2 (COX-2) mRNA in a time- and dose-dependent manner. A p38 mitogen-activated protein kinase (MAPK) inhibitor, SB203580, blocked elevation of COX-2 mRNA levels, whereas PD98059, which blocks the Erk1/2 cascade, partially suppressed the increase. Consistent with involvement of p38 MAPK, VacA-induced accumulation of COX-2 mRNA was reduced in AZ-521 cells overexpressing a dominant-negative p38 MAPK (DN-p38). Phosphatidylinositol-specific phospholipase C, which inhibits VacA-induced p38 MAPK activation, blocked VacA-induced COX-2 expression. In parallel with COX-2 expression, VacA increased prostaglandin E sub(2) (PGE sub(2)) production, which was inhibited by SB203580 and NS-398, a COX-2 inhibitor. VacA-induced PGE sub(2) production was markedly attenuated in AZ-521 cells stably expressing DN-p38. VacA increased transcription of a COX-2 promoter reporter gene and activated a COX-2 promoter containing mutated NF- Kappa B or NF-interleukin-6 sites but not a mutated cis-acting replication element (CRE) site, suggesting direct involvement of the activating transcription factor 2 (ATF-2)/CREB-binding region in VacA-induced COX-2 promoter activation. The reduction of ATF-2 expression in AZ-521 cells transformed with ATF-2-small interfering RNA duplexes resulted in suppression of COX-2 expression. Thus, VacA enhances PGE sub(2) production by AZ-521 cells through induction of COX-2 expression via the p38 MAPK/ATF-2 cascade, leading to activation of the CRE site in the COX-2 promoter. JF - Infection and Immunity AU - Hisatsune, Junzo AU - Yamasaki, Eiki AU - Nakayama, Masaaki AU - Shirasaka, Daisuke AU - Kurazono, Hisao AU - Katagata, Yohtaro AU - Inoue, Hiroyasu AU - Han, Jiahuai AU - Sap, Jan AU - Yahiro, Kinnosuke AU - Moss, Joel AU - Hirayama, Toshiya AD - Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 8528523, Japan. Division of Digestive Disease, Kobe University Graduate School of Medicine, Kobe 6500017, Japan. Laboratory of Veterinary Public Health, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka 5998531, Japan. Department of Biochemistry and Biotechnology, Faculty of Agriculture and Life Science, Hirosaki University, Hirosaki 0368561, Japan. Department of Food and Nutrition, Nara Women's University, Nara 6308506, Japan. Department of Immunology, The Scripps Research Institute, La Jolla, California 92037. Department of Molecular Pathology, University of Copenhagen, Copenhagen DK-2100, Denmark. Pulmonary-Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892-1590 Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 4472 EP - 4481 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 9 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Cyclooxygenase-2 KW - Helicobacter pylori KW - Promoters KW - Extracellular signal-regulated kinase KW - MAP kinase KW - Replication KW - Reporter gene KW - Activating transcription factor 2 KW - Phospholipase C KW - Prostaglandin E2 KW - NF- Kappa B protein KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21009214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Helicobacter+pylori+VacA+Enhances+Prostaglandin+E+sub%282%29+Production+through+Induction+of+Cyclooxygenase+2+Expression+via+a+p38+Mitogen-Activated+Protein+Kinase%2FActivating+Transcription+Factor+2+Cascade+in+AZ-521+Cells&rft.au=Hisatsune%2C+Junzo%3BYamasaki%2C+Eiki%3BNakayama%2C+Masaaki%3BShirasaka%2C+Daisuke%3BKurazono%2C+Hisao%3BKatagata%2C+Yohtaro%3BInoue%2C+Hiroyasu%3BHan%2C+Jiahuai%3BSap%2C+Jan%3BYahiro%2C+Kinnosuke%3BMoss%2C+Joel%3BHirayama%2C+Toshiya&rft.aulast=Hisatsune&rft.aufirst=Junzo&rft.date=2007-09-01&rft.volume=75&rft.issue=9&rft.spage=4472&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cyclooxygenase-2; Extracellular signal-regulated kinase; Promoters; MAP kinase; Reporter gene; Replication; Phospholipase C; Activating transcription factor 2; Prostaglandin E2; NF- Kappa B protein; Helicobacter pylori ER - TY - JOUR T1 - Staphylococcus aureus Biofilm Metabolism and the Influence of Arginine on Polysaccharide Intercellular Adhesin Synthesis, Biofilm Formation, and Pathogenesis AN - 21003563; 7557070 AB - Staphylococcus aureus and Staphylococcus epidermidis are the leading causes of nosocomial infections in the United States and often are associated with biofilms attached to indwelling medical devices. Despite the importance of biofilms, there is very little consensus about the metabolic requirements of S. aureus during biofilm growth. To assess the metabolic requirements of S. aureus growing in a biofilm, we grew USA200 and USA300 clonal types in biofilm flow cells and measured the extraction and accumulation of metabolites. In spite of the genetic differences, both clonal types extracted glucose and accumulated lactate, acetate, formate, and acetoin, suggesting that glucose was catabolized to pyruvate that was then catabolized via the lactate dehydrogenase, pyruvate formate-lyase, and butanediol pathways. Additionally, both clonal types selectively extracted the same six amino acids (serine, proline, arginine, glutamine, glycine, and threonine) from the culture medium. These data and recent speculation about the importance of arginine in biofilm growth and the function of arginine deiminase in USA300 clones led us to genetically inactivate the sole copy of the arginine deiminase operon by deleting the arginine/ornithine antiporter gene (arcD) in the USA200 clonal type and to assess the effect on biofilm development and pathogenesis. Although inactivation of arcD did completely inhibit arginine transport and did reduce polysaccharide intercellular adhesin accumulation, arcD mutants formed biofilms and achieved cell densities in catheter infection studies that were equivalent to those for isogenic wild-type strains. JF - Infection and Immunity AU - Zhu, Yefei AU - Weiss, Elizabeth C AU - Otto, Michael AU - Fey, Paul D AU - Smeltzer, Mark S AU - Somerville, Greg A AD - Department of Veterinary and Biomedical Sciences, University of Nebraska, Lincoln, Nebraska 68583. Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205. Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840. Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 4219 EP - 4226 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 9 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Adhesins KW - Glutamine KW - Cell density KW - Glucose KW - Cell culture KW - Metabolites KW - Polysaccharides KW - Pyruvic acid KW - ornithine KW - Biofilms KW - Staphylococcus aureus KW - Serine KW - Proline KW - Data processing KW - Amino acids KW - Acetoin KW - Glycine KW - Arginine KW - Acetic acid KW - L-Lactate dehydrogenase KW - Nosocomial infection KW - Catheters KW - Lactic acid KW - Arginine deiminase KW - Operons KW - Staphylococcus epidermidis KW - Threonine KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21003563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Staphylococcus+aureus+Biofilm+Metabolism+and+the+Influence+of+Arginine+on+Polysaccharide+Intercellular+Adhesin+Synthesis%2C+Biofilm+Formation%2C+and+Pathogenesis&rft.au=Zhu%2C+Yefei%3BWeiss%2C+Elizabeth+C%3BOtto%2C+Michael%3BFey%2C+Paul+D%3BSmeltzer%2C+Mark+S%3BSomerville%2C+Greg+A&rft.aulast=Zhu&rft.aufirst=Yefei&rft.date=2007-09-01&rft.volume=75&rft.issue=9&rft.spage=4219&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Adhesins; Glutamine; Cell density; Glucose; Metabolites; Cell culture; Polysaccharides; Pyruvic acid; ornithine; Biofilms; Serine; Proline; Amino acids; Data processing; Acetoin; Arginine; Glycine; Acetic acid; L-Lactate dehydrogenase; Nosocomial infection; Lactic acid; Catheters; Arginine deiminase; Operons; Threonine; Staphylococcus aureus; Staphylococcus epidermidis ER - TY - JOUR T1 - Quantifying the blood oxygenation level dependent effect in cerebral blood volume-weighted functional MRI at 9.4T AN - 20855687; 8368573 AB - In cerebral blood volume (CBV)-weighted functional MRI (fMRI) employing superparamagnetic contrast agent, iron dose and blood oxygenation level dependent (BOLD) contamination are two important issues for experimental design and CBV quantification. Both BOLD and CBV-weighted fMRI are based upon the susceptibility effect, to which spin-echo and gradient-echo sequences have different sensitivities. In the present study, CBV-weighted fMRI was conducted using spin-echo and gradient-echo sequences at 9.4T by systematically changing the doses of contrast agent. Results suggest that BOLD contamination is a significant component in CBV-weighted fMRI at high field, particularly when relatively low dose of contrast agent is administered. A mathematical model was developed to quantify the extravascular (EV) BOLD effect. With a TE of 35 ms, the EV BOLD effect was estimated to account for 76 - 12% of the observed spin-echo fMRI signal at 9.4T. These data suggest that correcting BOLD effect may be necessary for accurately quantifying activation-induced CBV changes at high field. Magn Reson Med 58:616-621, 2007. JF - Magnetic Resonance in Medicine AU - Lu, Hanbing AU - Scholl, Clara A AU - Zuo, Yantao AU - Stein, Elliot A AU - Yang, Yihong AD - Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA, luha@intra.nida.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 616 EP - 621 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 58 IS - 3 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Mathematical models KW - Data processing KW - Contamination KW - Functional magnetic resonance imaging KW - Blood KW - Contrast media KW - N.M.R. KW - Iron KW - Cerebral blood flow KW - W 30910:Imaging KW - N3 11002:Computational & theoretical neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20855687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Quantifying+the+blood+oxygenation+level+dependent+effect+in+cerebral+blood+volume-weighted+functional+MRI+at+9.4T&rft.au=Lu%2C+Hanbing%3BScholl%2C+Clara+A%3BZuo%2C+Yantao%3BStein%2C+Elliot+A%3BYang%2C+Yihong&rft.aulast=Lu&rft.aufirst=Hanbing&rft.date=2007-09-01&rft.volume=58&rft.issue=3&rft.spage=616&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21354 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Functional magnetic resonance imaging; Contrast media; Contamination; Blood; Data processing; Iron; N.M.R.; Cerebral blood flow; Mathematical models DO - http://dx.doi.org/10.1002/mrm.21354 ER - TY - JOUR T1 - Increasing the Efficiency of Clinical Trials of Antimicrobials: The Scientific Basis of Substantial Evidence of Effectiveness of Drugs AN - 20855511; 8349762 AB - In the United States, drug sponsors must obtain approval from the US Food and Drug Administration before licensure and widespread clinical use of drugs. In this article, I discuss the definition and history of the regulatory requirement for "substantial evidence" of effectiveness from "adequate and well-controlled" clinical trials of drugs. These requirements apply to antimicrobials as they do to other therapeutic drug classes, and they may be even more important in their application to antimicrobials, given issues of antimicrobial resistance. I will discuss the evidence requirements, using examples from clinical trials in diseases such as acute otitis media, acute bacterial sinusitis, and acute exacerbations of chronic bronchitis. Examination of the principles of substantial evidence also points to opportunities to improve the efficiency of confirmatory clinical trials of antimicrobials to obtain more clinically relevant and useful information without increasing the uncertainty regarding the safety and efficacy of these drugs. JF - Clinical Infectious Diseases AU - Powers, J H AD - 6700B Rockledge Dr., Rm. 1123, Bethesda, MD 20892, USA, powersjohn@mail.nih.gov Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - S153 EP - S162 VL - 45 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts B: Bacteriology KW - Otitis media KW - Drug resistance KW - Bronchitis KW - Sinusitis KW - Clinical trials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20855511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Increasing+the+Efficiency+of+Clinical+Trials+of+Antimicrobials%3A+The+Scientific+Basis+of+Substantial+Evidence+of+Effectiveness+of+Drugs&rft.au=Powers%2C+J+H&rft.aulast=Powers&rft.aufirst=J&rft.date=2007-09-01&rft.volume=45&rft.issue=&rft.spage=S153&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/10.1086%2F519253 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Drug resistance; Otitis media; Bronchitis; Sinusitis; Clinical trials DO - http://dx.doi.org/10.1086/519253 ER - TY - JOUR T1 - The anti-inflammatory activities of Staphylococcus aureus AN - 20848067; 8242534 AB - Staphylococcus aureus is a versatile and harmful pathogen in both hospital- and community-associated infections that range from superficial to systemic infections. S. aureus engages a multitude of mechanisms to subvert the innate immune response of the host, including inhibition of complement activation and neutralization of anti-microbial peptides. In addition, inflammatory cell and phagocyte recruitment is an integral part of the innate defense to staphylococcal infection and comprises a well-coordinated multi-step cascade of adhesive events. Recent and rapidly growing experimental evidence indicates the existence of a machinery of anti-adhesive and anti-chemotactic moieties of S. aureus that allow the bacterium to interfere with specific adhesive steps of the homing mechanism of leukocytes. Understanding the functions of these S. aureus-derived anti-inflammatory agents could also provide the platform for designing new therapies in several inflammatory and autoimmune diseases. JF - Trends in Immunology AU - Chavakis, T AU - Preissner, K T AU - Herrmann, M Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 408 EP - 418 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 28 IS - 9 SN - 1471-4906, 1471-4906 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Autoimmune diseases KW - Leukocytes KW - Disseminated infection KW - Pathogens KW - Cell adhesion KW - Inflammation KW - Leukocyte migration KW - Inflammatory diseases KW - Phagocytes KW - Reviews KW - Complement activation KW - Immune response KW - Staphylococcus aureus KW - Adhesives KW - Antimicrobial peptides KW - Antiinflammatory agents KW - F 06930:Autoimmunity KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20848067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Immunology&rft.atitle=The+anti-inflammatory+activities+of+Staphylococcus+aureus&rft.au=Chavakis%2C+T%3BPreissner%2C+K+T%3BHerrmann%2C+M&rft.aulast=Chavakis&rft.aufirst=T&rft.date=2007-09-01&rft.volume=28&rft.issue=9&rft.spage=408&rft.isbn=&rft.btitle=&rft.title=Trends+in+Immunology&rft.issn=14714906&rft_id=info:doi/10.1016%2Fj.it.2007.07.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Disseminated infection; Leukocytes; Autoimmune diseases; Pathogens; Inflammation; Cell adhesion; Leukocyte migration; Inflammatory diseases; Phagocytes; Reviews; Complement activation; Immune response; Adhesives; Antiinflammatory agents; Antimicrobial peptides; Staphylococcus aureus DO - http://dx.doi.org/10.1016/j.it.2007.07.002 ER - TY - JOUR T1 - Metabolomic and Genetic Analysis of Biomarkers for Peroxisome Proliferator-Activated Receptor alpha Expression and Activation AN - 20800008; 7559538 AB - Peroxisome proliferator-activated receptor alpha (PPAR alpha ) is a nuclear receptor with manifold effects on intermediary metabolism. To define a set of urinary biomarkers that could be used to determine the efficacy of PPAR alpha agonists, a metabolomic investigation was undertaken in wild-type and Ppar alpha -null mice fed for 2 wk either a regular diet or a diet containing the PPAR alpha ligand Wy-14,643 ([4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio] acetic acid), and their urine was analyzed by ultra-performance liquid chromatography coupled with time-of-flight mass spectrometry. Principal components analysis of 6393 accurate mass positive ions revealed clustering as a single phenotype of the treated and untreated Ppar alpha (-/-) mice plus two additional discrete phenotypes for the treated and untreated Ppar alpha (+/+) mice. Biomarkers of PPAR alpha activation were identified from their accurate masses and confirmed by tandem mass spectrometry of authentic compounds. Biomarkers were quantitated from raw chromatographic data using appropriate calibration curves. PPAR alpha urinary biomarkers highly statistically significantly elevated by Wy-14,643 treatment included 11{szligbeta}-hydroxy-3,20-dioxopregn-4-en-21-oic acid (>3700-fold), 11{szligbeta},20-dihydroxy-3-oxopregn-4-en-21-oic acid (50-fold), nicotinamide (>2-fold), nicotinamide 1-oxide (5-fold), 1-methylnicotinamide (1.5-fold), hippuric acid (2-fold), and 2,8-dihydroxyquinoline-{szligbeta}-D-glucuronide (3-fold). PPAR alpha urinary biomarkers highly statistically significantly attenuated by Wy-14,643 treatment included xanthurenic acid (1.3-fold), hexanoylglycine (20-fold), phenylpropionylglycine (4-fold), and cinnamoylglycine (9-fold). These biomarkers arise from PPAR alpha effects on tryptophan, corticosterone, and fatty acid metabolism and on glucuronidation. This study underscores the power of mass spectrometry-based metabolomics combined with genetically modified mice in the definition of monogenic metabolic phenotypes. JF - Molecular Endocrinology AU - Zhen, Yueying AU - Krausz, Kristopher W AU - Chen, Chi AU - Idle, Jeffrey R AU - Gonzalez, Frank J AD - Laboratory of Metabolism (Y.Z., K.W.K., C.C., F.J.G.), National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 2136 EP - 2151 PB - Endocrine Society, 8400 Connecticut Ave Suite 900 Chevy Chase MD 20815-5817 USA, [mailto:societyservices@endo-society.org], [URL:http://www.endo-society.org/] VL - 21 IS - 9 SN - 0888-8809, 0888-8809 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Diets KW - Ions KW - Tryptophan KW - Data processing KW - Peroxisome proliferator-activated receptors KW - nicotinamide KW - Nuclear receptors KW - Genetic analysis KW - Acetic acid KW - biomarkers KW - Mass spectroscopy KW - xanthurenic acid KW - Corticosterone KW - Liquid chromatography KW - Urine KW - Principal components analysis KW - Fatty acids KW - Metabolism KW - metabolomics KW - G 07870:Mammals KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20800008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Endocrinology&rft.atitle=Metabolomic+and+Genetic+Analysis+of+Biomarkers+for+Peroxisome+Proliferator-Activated+Receptor+alpha+Expression+and+Activation&rft.au=Zhen%2C+Yueying%3BKrausz%2C+Kristopher+W%3BChen%2C+Chi%3BIdle%2C+Jeffrey+R%3BGonzalez%2C+Frank+J&rft.aulast=Zhen&rft.aufirst=Yueying&rft.date=2007-09-01&rft.volume=21&rft.issue=9&rft.spage=2136&rft.isbn=&rft.btitle=&rft.title=Molecular+Endocrinology&rft.issn=08888809&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Diets; Tryptophan; Ions; Data processing; Peroxisome proliferator-activated receptors; nicotinamide; Nuclear receptors; Genetic analysis; biomarkers; Acetic acid; Mass spectroscopy; xanthurenic acid; Corticosterone; Urine; Liquid chromatography; Principal components analysis; Fatty acids; metabolomics; Metabolism ER - TY - JOUR T1 - Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development AN - 20799072; 7565471 AB - Muscarinic acetylcholine receptors (mAChRs), M sub(1)-M sub(5), regulate the activity of numerous fundamental central and peripheral functions. The lack of small-molecule ligands that can block or activate specific mAChR subtypes with high selectivity has remained a major obstacle in defining the roles of the individual receptor subtypes and in the development of novel muscarinic drugs. Recently, phenotypic analysis of mutant mouse strains deficient in each of the five mAChR subtypes has led to a wealth of new information regarding the physiological roles of the individual receptor subtypes. Importantly, these studies have identified specific mAChR-regulated pathways as potentially novel targets for the treatment of various important disorders including Alzheimer's disease, schizophrenia, pain, obesity and diabetes. JF - Nature Reviews: Drug Discovery AU - Wess, Juergen AU - Eglen, Richard M AU - Gautam, Dinesh AD - Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0810, USA., jwess@helix.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 721 EP - 733 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 6 IS - 9 SN - 1474-1784, 1474-1784 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Diabetes mellitus KW - Schizophrenia KW - Obesity KW - Neurodegenerative diseases KW - Mental disorders KW - Reviews KW - Acetylcholine receptors (muscarinic) KW - Alzheimer's disease KW - Drug development KW - Pain KW - N3 11028:Neuropharmacology & toxicology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20799072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Drug+Discovery&rft.atitle=Muscarinic+acetylcholine+receptors%3A+mutant+mice+provide+new+insights+for+drug+development&rft.au=Wess%2C+Juergen%3BEglen%2C+Richard+M%3BGautam%2C+Dinesh&rft.aulast=Wess&rft.aufirst=Juergen&rft.date=2007-09-01&rft.volume=6&rft.issue=9&rft.spage=721&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Drug+Discovery&rft.issn=14741784&rft_id=info:doi/10.1038%2Fnrd2379 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Schizophrenia; Diabetes mellitus; Neurodegenerative diseases; Obesity; Mental disorders; Reviews; Alzheimer's disease; Acetylcholine receptors (muscarinic); Pain; Drug development DO - http://dx.doi.org/10.1038/nrd2379 ER - TY - JOUR T1 - The ongoing evolution of proteomics in malignancy AN - 20777000; 8242408 AB - The complementary fields of genomics and proteomics offer insights into the molecular mechanisms of diseases. While genomics seeks to define our genetic substrate, proteomics explores the structure and function of proteins, which are the end effectors of our genes. Proteomics has been revolutionized in the past decade by the application of techniques such as protein arrays, two-dimensional gel electrophoresis, and mass spectrometry. These techniques have tremendous potential for biomarker development, target validation, diagnosis, prognosis, and optimization of treatment in medical care, especially in the field of clinical oncology. We will discuss innovations in proteomic technologies and highlight their prospective applications to patient care. JF - Drug Discovery Today AU - Dhamoon, A S AU - Kohn, E C AU - Azad, N S AD - Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr. MSC 1500, Bethesda, MD 20892, United States, azadn@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 700 EP - 708 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 12 IS - 17-18 SN - 1359-6446, 1359-6446 KW - Biotechnology and Bioengineering Abstracts KW - Molecular modelling KW - Prognosis KW - Oncology KW - biomarkers KW - Mass spectroscopy KW - Gel electrophoresis KW - Malignancy KW - Structure-function relationships KW - Protein arrays KW - proteomics KW - genomics KW - Evolution KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20777000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Discovery+Today&rft.atitle=The+ongoing+evolution+of+proteomics+in+malignancy&rft.au=Dhamoon%2C+A+S%3BKohn%2C+E+C%3BAzad%2C+N+S&rft.aulast=Dhamoon&rft.aufirst=A&rft.date=2007-09-01&rft.volume=12&rft.issue=17-18&rft.spage=700&rft.isbn=&rft.btitle=&rft.title=Drug+Discovery+Today&rft.issn=13596446&rft_id=info:doi/10.1016%2Fj.drudis.2007.07.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Malignancy; Structure-function relationships; Protein arrays; Prognosis; Oncology; genomics; proteomics; biomarkers; Gel electrophoresis; Mass spectroscopy; Evolution DO - http://dx.doi.org/10.1016/j.drudis.2007.07.015 ER - TY - JOUR T1 - Identification of arsenic-binding proteins in human breast cancer cells AN - 20753130; 7602754 AB - As a cancer chemotherapeutic drug, arsenic acts on numerous intracellular signal transduction pathways in cancer cells. However, its mechanism of actions is still not fully understood. Previous studies suggest that arsenic reacts with closely spaced cysteine (Cys) residues of proteins with high Cys content and accessible sulfhydryl (SH) groups. In this study, human breast cancer cell line MCF-7 was examined as a cellular model to explore arsenic-binding proteins and the mechanism of binding. An arsenic-biotin conjugate was synthesized by coupling the pentafluorophenol ester of biotin with p-aminophenylarsenoxide. Arsenic-binding proteins were eluted with streptavidin resin from arsenic-biotin treated MCF-7 cells, separated by polyacrylamide gel electrophoresis, and identified by matrix assisted laser desorption ionization mass spectrometry (MALDI-MS). Arsenic-binding properties of two of these proteins, beta -tubulin and pyruvate kinase M2 (PKM2), were studied further in vitro and the biological consequences of this binding was evaluated. Binding assay with Western blotting confirmed binding of beta -tubulin and PKM2 by arsenic in a concentration-dependent manner. Arsenic binding inhibited tubulin polymerization, but surprisingly had no effect on PKM2 activity. Molecular modeling showed that binding of Cys12 alone or vicinal Cys residues (Cys12 and Cys213) of beta -tubulin by arsenic blocked the active site for access of GTP, which is necessary for tubulin polymerization. On the contrary, all Cys residues of PKM2 were far away from the active site of the enzyme. In summary, this study confirmed beta -tubulin and PKM2 as arsenic-binding proteins in MCF-7 cells. Functional consequence of such binding may depend on whether arsenic binding causes conformational changes or blocks active sites of target proteins. JF - Cancer Letters AU - Zhang, Xinyan AU - Yang, Fan AU - Shim, Joong-Youn AU - Kirk, Kenneth L AU - Anderson, D Eric AU - Chen, Xiaoxin AD - Cancer Research Program, Julius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, 700 George St., Durham, NC 27707, USA, fyang@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 95 EP - 106 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 255 IS - 1 SN - 0304-3835, 0304-3835 KW - Toxicology Abstracts KW - Arsenic KW - Cysteine KW - Breast cancer KW - Western blotting KW - Molecular modelling KW - Resins KW - Polymerization KW - Desorption KW - GTP KW - Enzymes KW - Esters KW - Mass spectroscopy KW - Gel electrophoresis KW - Pyruvate kinase KW - Tumor cell lines KW - pentafluorophenol KW - Lasers KW - Tubulin KW - Biotin KW - streptavidin KW - Signal transduction KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20753130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Letters&rft.atitle=Identification+of+arsenic-binding+proteins+in+human+breast+cancer+cells&rft.au=Zhang%2C+Xinyan%3BYang%2C+Fan%3BShim%2C+Joong-Youn%3BKirk%2C+Kenneth+L%3BAnderson%2C+D+Eric%3BChen%2C+Xiaoxin&rft.aulast=Zhang&rft.aufirst=Xinyan&rft.date=2007-09-01&rft.volume=255&rft.issue=1&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Cancer+Letters&rft.issn=03043835&rft_id=info:doi/10.1016%2Fj.canlet.2007.03.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Western blotting; Resins; Arsenic; Desorption; Polymerization; Enzymes; GTP; Esters; Gel electrophoresis; Mass spectroscopy; Pyruvate kinase; Tumor cell lines; pentafluorophenol; Cysteine; Breast cancer; Lasers; Tubulin; Biotin; Signal transduction; streptavidin DO - http://dx.doi.org/10.1016/j.canlet.2007.03.025 ER - TY - JOUR T1 - Alcohol, Smoking, and Body Size in Relation to Incident Hodgkin's and Non-Hodgkin's Lymphoma Risk AN - 20723319; 7554738 AB - Studies associate alcohol consumption, cigarette smoking, and body size with the risk of overall or subtype lymphoma. Current data come mostly from case-control studies or prospective studies with few cases. In the prospective National Institutes of Health-former American Association of Retired Persons (NIH-AARP) Diet and Health Study, the authors assessed the above lifestyle factors via baseline questionnaire among 285,079 men and 188,905 women aged 50-71 years and ascertained histologically confirmed Hodgkin's lymphoma (n = 58) and non-Hodgkin's lymphoma (n = 1,381) cases through linkage with cancer registries from 1995 to 2000. Compared with nondrinkers, alcohol consumers had a lower risk for non-Hodgkin's lymphoma overall (for >28 drinks/week: adjusted relative risk (RR) = 0.77, 95% confidence interval (CI): 0.59, 1.00; p sub(trend) among drinkers = 0.02) and for its main subtypes. Compared with never smokers, current smokers and recent quitters ( less than or equal to 4 years ago) had higher risk of Hodgkin's lymphoma (RR = 2.25, 95% CI: 1.04, 4.89; RR = 4.20, 95% CI: 1.94, 9.09, respectively), whereas current or former smokers had lower risk of follicular non-Hodgkin's lymphoma (RR = 0.67, 95% CI: 0.52, 0.86). Severe obesity (body mass index of greater than or equal to 35: RR = 1.29, 95% CI: 1.02, 1.64) and taller height (RR = 1.19, 95% CI: 1.03, 1.38) were associated moderately with non-Hodgkin's lymphoma. These findings add to the evidence that lifestyle factors and relevant anthropometric characteristics play a role in lymphoma etiology. JF - American Journal of Epidemiology AU - Lim, Unhee AU - Morton, Lindsay M AU - Subar, Amy F AU - Baris, Dalsu AU - Stolzenberg-Solomon, Rachael AU - Leitzmann, Michael AU - Kipnis, Victor AU - Mouw, Traci AU - Carroll, Leslie AU - Schatzkin, Arthur AU - Hartge, Patricia AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 697 EP - 708 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 166 IS - 6 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; Immunology Abstracts; Toxicology Abstracts KW - non-Hodgkin's lymphoma KW - Risk assessment KW - Hodgkin's disease KW - obesity KW - body size KW - Non-Hodgkin's lymphoma KW - body mass KW - Risk factors KW - Cigarette smoking KW - Body size KW - Consumers KW - Ethanol KW - Diets KW - Alcohol KW - Inventories KW - Obesity KW - Etiology KW - Beverages KW - Data processing KW - Cancer KW - Body mass index KW - lymphoma KW - X 24380:Social Poisons & Drug Abuse KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20723319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Alcohol%2C+Smoking%2C+and+Body+Size+in+Relation+to+Incident+Hodgkin%27s+and+Non-Hodgkin%27s+Lymphoma+Risk&rft.au=Lim%2C+Unhee%3BMorton%2C+Lindsay+M%3BSubar%2C+Amy+F%3BBaris%2C+Dalsu%3BStolzenberg-Solomon%2C+Rachael%3BLeitzmann%2C+Michael%3BKipnis%2C+Victor%3BMouw%2C+Traci%3BCarroll%2C+Leslie%3BSchatzkin%2C+Arthur%3BHartge%2C+Patricia&rft.aulast=Lim&rft.aufirst=Unhee&rft.date=2007-09-01&rft.volume=166&rft.issue=6&rft.spage=3452&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Diets; Risk assessment; Obesity; Inventories; Etiology; Data processing; Hodgkin's disease; Beverages; Cancer; Non-Hodgkin's lymphoma; Risk factors; Cigarette smoking; Body size; Consumers; Body mass index; Ethanol; non-Hodgkin's lymphoma; Alcohol; body mass; obesity; body size; lymphoma ER - TY - JOUR T1 - Effect of Concomitantly Administered Rifampin on the Pharmacokinetics and Safety of Atazanavir Administered Twice Daily AN - 20723216; 7553974 AB - The potent induction of hepatic cytochrome P450 3A isoforms by rifampin complicates therapy for coinfection with human immunodeficiency virus (HIV) and Mycobacterium tuberculosis. We performed an open-label, single-arm study to assess the safety and pharmacokinetic interactions of the HIV protease inhibitor atazanavir coadministered with rifampin. Ten healthy HIV-negative subjects completed pharmacokinetic sampling at steady state while receiving 300 mg atazanavir every 12 h without rifampin (period 1), 300 mg atazanavir every 12 h with 600 mg rifampin every 24 h (period 2), and 400 mg atazanavir every 12 h with 600 mg rifampin every 24 h (period 3). During period 1, the mean concentration of drug in serum at 12 h (C sub(12 h)) was 811 ng/ml (range, 363 to 2,484 ng/ml) for atazanavir, similar to historic seronegative data for once-daily treatment with 300 mg atazanavir boosted with 100 mg ritonavir. During periods 2 and 3, the mean C sub(12 h) values for atazanavir were 44 ng/ml (range, <25 to187 ng/ml) and 113 ng/ml (range, 39 to 260 ng/ml), respectively, well below historic seronegative data for once-daily treatment with 400 mg atazanavir without ritonavir. Although safe and generally well tolerated, 300 mg or 400 mg atazanavir administered every 12 h did not maintain adequate plasma exposure when coadministered with rifampin. JF - Antimicrobial Agents & Chemotherapy AU - Acosta, Edward P AU - Kendall, Michelle A AU - Gerber, John G AU - Alston-Smith, Beverly AU - Koletar, Susan L AU - Zolopa, Andrew R AU - Agarwala, Sangeeta AU - Child, Michael AU - Bertz, Richard AU - Hosey, Lara AU - Haas, David W AD - University of Alabama at Birmingham, Birmingham, Alabama. Statistical and Data Analysis Center, Harvard School of Public Health, Boston, Massachusetts. University of Colorado Health Sciences Center, Denver, Colorado. DAIDS, NIAID, NIH, Bethesda, Maryland. Ohio State University, Columbus, Ohio. Stanford University, Stanford, California. Bristol-Myers Squibb, Princeton, New Jersey. Social & Scientific Systems Inc., Silver Spring, Maryland. Vanderbilt University School of Medicine, Nashville, Tennessee Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 3104 EP - 3110 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 51 IS - 9 SN - 0066-4804, 0066-4804 KW - HIV KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Rifampin KW - Data processing KW - Human immunodeficiency virus KW - Ritonavir KW - Proteinase inhibitors KW - Liver KW - Cytochrome P450 KW - Sampling KW - Drugs KW - Pharmacokinetics KW - Mycobacterium tuberculosis KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20723216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Effect+of+Concomitantly+Administered+Rifampin+on+the+Pharmacokinetics+and+Safety+of+Atazanavir+Administered+Twice+Daily&rft.au=Acosta%2C+Edward+P%3BKendall%2C+Michelle+A%3BGerber%2C+John+G%3BAlston-Smith%2C+Beverly%3BKoletar%2C+Susan+L%3BZolopa%2C+Andrew+R%3BAgarwala%2C+Sangeeta%3BChild%2C+Michael%3BBertz%2C+Richard%3BHosey%2C+Lara%3BHaas%2C+David+W&rft.aulast=Acosta&rft.aufirst=Edward&rft.date=2007-09-01&rft.volume=51&rft.issue=9&rft.spage=3104&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Rifampin; Data processing; Ritonavir; Proteinase inhibitors; Liver; Sampling; Cytochrome P450; Drugs; Pharmacokinetics; Human immunodeficiency virus; Mycobacterium tuberculosis ER - TY - JOUR T1 - A quantum chemical study of the mechanism of action of Vitamin K carboxylase (VKC) AN - 20721295; 8284088 AB - A reaction path including transition states is generated for the Dowd mechanism [P. Dowd, R. Hershlne, S.W. Ham, S. Naganathan. Vitamin K and energy transduction: a base strength amplification mechanism. Science 269 (2005) 1684-1691] of action for Vitamin K carboxylase (VKC) using quantum chemical methods (B3LYP/6-311G**). VKC, an essential enzyme in mammalian systems, catalyzes the conversion of hydroquinone form of Vitamin K to the epoxide form in the presence of oxygen. An intermediate species of the oxidation of Vitamin K, an alkoxide, acts apparently to abstract the gamma hydrogen from specifically located glutamate residues. We are able to follow the Dowd proposed path to generate this alkoxide species. The geometries of the proposed model intermediates and transition states in the mechanism are energy optimized. We find that the most energetic step in the mechanism is the uni-deprotonation of the hydroquinone - once this occurs, there is only a small barrier of 3.5kcal/mol for the interaction of oxygen with the carbon to be attacked - and then the reaction proceeds downhill in free energy to form the critical alkoxide species. The results are consistent with the idea that the enzyme probably acts to facilitate the formation of the epoxide by reducing the energy required to deprotonate the hydroquinone form. JF - Journal of Molecular Graphics and Modelling AU - Davis, CH AU - Deerfield, D AU - Wymore, T AU - Stafford, D W AU - Pedersen, L G AD - NIEHS, Research Triangle Park, NC 27009, United States, Lee_Pedersen@unc.edu Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 409 EP - 414 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 26 IS - 2 SN - 1093-3263, 1093-3263 KW - Biotechnology and Bioengineering Abstracts KW - Epoxides KW - Hydroquinone KW - Energy transduction KW - Enzymes KW - Hydrogen KW - Free energy KW - Models KW - Oxygen KW - Carbon KW - Oxidation KW - Ham KW - Vitamin K KW - Glutamic acid KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20721295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Graphics+and+Modelling&rft.atitle=A+quantum+chemical+study+of+the+mechanism+of+action+of+Vitamin+K+carboxylase+%28VKC%29&rft.au=Davis%2C+CH%3BDeerfield%2C+D%3BWymore%2C+T%3BStafford%2C+D+W%3BPedersen%2C+L+G&rft.aulast=Davis&rft.aufirst=CH&rft.date=2007-09-01&rft.volume=26&rft.issue=2&rft.spage=409&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Graphics+and+Modelling&rft.issn=10933263&rft_id=info:doi/10.1016%2Fj.jmgm.2006.10.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Epoxides; Hydroquinone; Energy transduction; Enzymes; Hydrogen; Free energy; Models; Oxygen; Carbon; Ham; Oxidation; Vitamin K; Glutamic acid DO - http://dx.doi.org/10.1016/j.jmgm.2006.10.006 ER - TY - JOUR T1 - Nelfinavir, A Lead HIV Protease Inhibitor, Is a Broad-Spectrum, Anticancer Agent that Induces Endoplasmic Reticulum Stress, Autophagy, and Apoptosis In vitro and In vivo AN - 20696730; 7556263 AB - PURPOSE: The development of new cancer drugs is slow and costly. HIV protease inhibitors are Food and Drug Administration approved for HIV patients. Because these drugs cause toxicities that can be associated with inhibition of Akt, an emerging target in cancer, we assessed the potential of HIV protease inhibitors as anticancer agents. Experimental Design: HIV protease inhibitors were screened in vitro using assays that measure cellular proliferation, apoptotic and nonapoptotic cell death, endoplasmic reticulum (ER) stress, autophagy, and activation of Akt. Nelfinavir was tested in non-small cell lung carcinoma (NSCLC) xenografts with biomarker assessment. RESULTS: Three of six HIV protease inhibitors, nelfinavir, ritonavir, and saquinavir, inhibited proliferation of NSCLC cells, as well as every cell line in the NCI60 cell line panel. Nelfinavir was most potent with a mean 50% growth inhibition of 5.2 mu mol/L, a concentration achievable in HIV patients. Nelfinavir caused two types of cell death, caspase-dependent apoptosis and caspase-independent death that was characterized by induction of ER stress and autophagy. Autophagy was protective because an inhibitor of autophagy increased nelfinavir-induced death. Akt was variably inhibited by HIV protease inhibitors, but nelfinavir caused the greatest inhibition of endogenous and growth factor-induced Akt activation. Nelfinavir decreased the viability of a panel of drug-resistant breast cancer cell lines and inhibited the growth of NSCLC xenografts that was associated with induction of ER stress, autophagy, and apoptosis. CONCLUSIONS: Nelfinavir is a lead HIV protease inhibitor with pleiotropic effects in cancer cells. Given its wide spectrum of activity, oral availability, and familiarity of administration, nelfinavir is a Food and Drug Administration-approved drug that could be repositioned as a cancer therapeutic. JF - Clinical Cancer Research AU - Gills, Joell J AU - LoPiccolo, Jaclyn AU - Tsurutani, Junji AU - Shoemaker, Robert H AU - Best, Carolyn JM AU - Abu-Asab, Mones S AU - Borojerdi, Jennifer AU - Warfel, Noel A AU - Gardner, Erin R AU - Danish, Matthew AU - Hollander, MChristine AU - Kawabata, Shigeru AU - Tsokos, Maria AU - Figg, William D AU - Steeg, Patricia S AU - Dennis, Phillip A AD - Authors' Affiliations: Medical Oncology Branch, Molecular Therapeutics Program, Laboratory of Pathology, Clinical Pharmacology Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - 5183 EP - 5194 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 13 IS - 17 SN - 1078-0432, 1078-0432 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Apoptosis KW - Saquinavir KW - Drug resistance KW - Non-small cell lung carcinoma KW - Proteinase inhibitors KW - Stress KW - Drug development KW - Toxicity KW - Familiarity KW - biomarkers KW - Antitumor agents KW - Lead KW - Endoplasmic reticulum KW - Tumor cell lines KW - Human immunodeficiency virus KW - Ritonavir KW - AKT protein KW - Breast cancer KW - Xenografts KW - Phagocytosis KW - Nelfinavir KW - Cell proliferation KW - V 22360:AIDS and HIV KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20696730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Nelfinavir%2C+A+Lead+HIV+Protease+Inhibitor%2C+Is+a+Broad-Spectrum%2C+Anticancer+Agent+that+Induces+Endoplasmic+Reticulum+Stress%2C+Autophagy%2C+and+Apoptosis+In+vitro+and+In+vivo&rft.au=Gills%2C+Joell+J%3BLoPiccolo%2C+Jaclyn%3BTsurutani%2C+Junji%3BShoemaker%2C+Robert+H%3BBest%2C+Carolyn+JM%3BAbu-Asab%2C+Mones+S%3BBorojerdi%2C+Jennifer%3BWarfel%2C+Noel+A%3BGardner%2C+Erin+R%3BDanish%2C+Matthew%3BHollander%2C+MChristine%3BKawabata%2C+Shigeru%3BTsokos%2C+Maria%3BFigg%2C+William+D%3BSteeg%2C+Patricia+S%3BDennis%2C+Phillip+A&rft.aulast=Gills&rft.aufirst=Joell&rft.date=2007-09-01&rft.volume=13&rft.issue=17&rft.spage=5183&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Apoptosis; Saquinavir; Drug resistance; Proteinase inhibitors; Non-small cell lung carcinoma; Stress; Drug development; Toxicity; Familiarity; Antitumor agents; biomarkers; Lead; Endoplasmic reticulum; Tumor cell lines; Ritonavir; AKT protein; Breast cancer; Xenografts; Cell proliferation; Nelfinavir; Phagocytosis; Human immunodeficiency virus ER - TY - JOUR T1 - Risk of human T-lymphotropic virus type I-associated diseases in Jamaica with common HLA types AN - 20679245; 8079587 AB - Human T-lymphotropic virus-I (HTLV-I) causes adult T-cell leukemia/lymphoma (ATL) and HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). We postulated a higher disease risk for people with common human leukocyte antigen (HLA) types, due to a narrower immune response against viral or neoplastic antigens, compared to people with uncommon types. HLA class-I (A,B) and class-II (DRB1, DQB1) allele and haplotype frequencies in 56 ATL patients, 59 HAM/TSP patients and 190 population-based, asymptomatic HTLV-I-infected carriers were compared by logistic regression overall (score test) and with odds ratios (ORs) for common types (prevalence >50% of asymptomatic carriers) and by prevalence quartile. HTLV-I proviral load between asymptomatic carriers with common versus uncommon types was compared by t-test. ATL differed from asymptomatic carriers in overall DQB1 allele and class-I haplotype frequencies (p 0.04). ATL risk was increased significantly with common HLA-B (OR 2.25, 95% CI 1.19-4.25) and DRB1 (OR 2.11, 95% CI 1.13-3.40) alleles. Higher prevalence HLA-B alleles were associated with higher ATL risk (OR 1.14 per quartile, ptrend = 0.02). Asymptomatic carriers with common HLA-B alleles had marginally higher HTLV-I proviral load (p = 0.057). HAM/TSP risk did not differ consistently with common HLA types. Thus, ATL risk, but not HAM/TSP risk, was increased with higher prevalence HLA-B alleles. Perhaps breadth of cellular immunity affects risk of this viral leukemia/lymphoma. JF - International Journal of Cancer AU - Goedert, James J AU - Li, Hong-Chuan AU - Gao, Xiao-Jiang AU - Chatterjee, Nilanjan AU - Sonoda, Shunro AU - Biggar, Robert J AU - Cranston, Beverley AU - Kim, Norma AU - Carrington, Mary AU - Morgan, Owen AU - Hanchard, Barrie AU - Hisada, Michie AD - Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, goedertj@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 1092 EP - 1097 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 121 IS - 5 SN - 0020-7136, 0020-7136 KW - Virology & AIDS Abstracts; Risk Abstracts; Immunology Abstracts KW - Histocompatibility antigen HLA KW - ASW, Greater Antilles, Jamaica KW - Spinal cord KW - Human T-lymphotropic virus 1 KW - haplotypes KW - Cancer KW - Leukemia KW - Haplotypes KW - Immunity (cell-mediated) KW - Risk factors KW - Tropical spastic paraparesis KW - Central nervous system diseases KW - Lymphocytes T KW - Gene frequency KW - Immune response KW - lymphoma KW - Lymphoma KW - V 22350:Immunology KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20679245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Risk+of+human+T-lymphotropic+virus+type+I-associated+diseases+in+Jamaica+with+common+HLA+types&rft.au=Goedert%2C+James+J%3BLi%2C+Hong-Chuan%3BGao%2C+Xiao-Jiang%3BChatterjee%2C+Nilanjan%3BSonoda%2C+Shunro%3BBiggar%2C+Robert+J%3BCranston%2C+Beverley%3BKim%2C+Norma%3BCarrington%2C+Mary%3BMorgan%2C+Owen%3BHanchard%2C+Barrie%3BHisada%2C+Michie&rft.aulast=Goedert&rft.aufirst=James&rft.date=2007-09-01&rft.volume=121&rft.issue=5&rft.spage=1092&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22767 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Leukemia; Immunity (cell-mediated); Haplotypes; Spinal cord; Tropical spastic paraparesis; Risk factors; Central nervous system diseases; Lymphocytes T; Gene frequency; Immune response; Lymphoma; haplotypes; lymphoma; Cancer; Human T-lymphotropic virus 1; ASW, Greater Antilles, Jamaica DO - http://dx.doi.org/10.1002/ijc.22767 ER - TY - JOUR T1 - Variation in breast cancer hormone receptor and HER2 levels by etiologic factors: A population-based analysis AN - 20649127; 8079585 AB - Evidence suggests that breast cancer hormone receptor status varies by etiologic factors, but studies have been inconsistent. In a population-based case-control study in Poland that included 2,386 cases and 2,502 controls, we assessed ER- and PR status of tumors based on clinical records according to etiologic exposure data collected via interview. For 842 cancers, we evaluated ER-, ER-, PR and HER2 levels by semiquantitative microscopic scoring of immunostained tissue microarrays and a quantitative immunofluorescence method, automated quantitative analysis (AQUATM). We related marker levels in tumors to etiologic factors, using standard regression models and novel statistical methods, permitting adjustment for both correlated tumor features and exposures. Results obtained with different assays were generally consistent. Receptor levels varied most significantly with body mass index (BMI), a factor that was inversely related to risk among premenopausal women and directly related to risk among postmenopausal women with larger tumors. After adjustment for correlated markers, exposures and pathologic characteristics, PR and HER2 AQUA levels were inversely related to BMI among premenopausal women (p-trend = 0.01, both comparisons), whereas among postmenopausal women, PR levels were associated directly with BMI (p-trend = 0.002). Among postmenopausal women, analyses demonstrated that BMI was related to an interaction of PR and HER2: odds ratio (OR) = 0.86 (95% CI = 0.69-1.07) for low PR and HER2 expression vs. OR = 1.78 (95% CI = 1.25-2.55) for high expression (p-heterogeneity = 0.001). PR and HER2 levels in breast cancer vary by BMI, suggesting a heterogeneous etiology for tumors related to these markers. JF - International Journal of Cancer AU - Sherman, Mark E AU - Rimm, David L AU - Yang, Xiaohong R AU - Chatterjee, Nilanjan AU - Brinton, Louise A AU - Lissowska, Jolanta AU - Peplonska, Beata AU - Szeszenia-Dabrowska, Neonila AU - Zatonski, Witold AU - Cartun, Richard AU - Mandich, Daniza AU - Rymkiewicz, Grzegorz AU - Ligaj, Marcin AU - Lukaszek, Stanislaw AU - Kordek, Radzislaw AU - Kalaylioglu, Zynep AU - Harigopal, Malini AU - Charrette, Lori AU - Falk, Roni T AU - Richesson, Douglas AU - Anderson, William F AU - Hewitt, Stephen M AU - Garcia-Closas, Montserrat AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, shermanm@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 1079 EP - 1085 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 121 IS - 5 SN - 0020-7136, 0020-7136 KW - Risk Abstracts; Oncogenes & Growth Factors Abstracts KW - Etiology KW - ErbB-2 protein KW - Mathematical models KW - post-menopause KW - Statistical analysis KW - Tumors KW - Immunofluorescence KW - Hormones KW - Models KW - body mass KW - Post-menopause KW - Poland KW - Regression analysis KW - Breast cancer KW - Body mass index KW - B 26660:Miscellaneous Oncogenes & Growth Factors KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20649127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Variation+in+breast+cancer+hormone+receptor+and+HER2+levels+by+etiologic+factors%3A+A+population-based+analysis&rft.au=Sherman%2C+Mark+E%3BRimm%2C+David+L%3BYang%2C+Xiaohong+R%3BChatterjee%2C+Nilanjan%3BBrinton%2C+Louise+A%3BLissowska%2C+Jolanta%3BPeplonska%2C+Beata%3BSzeszenia-Dabrowska%2C+Neonila%3BZatonski%2C+Witold%3BCartun%2C+Richard%3BMandich%2C+Daniza%3BRymkiewicz%2C+Grzegorz%3BLigaj%2C+Marcin%3BLukaszek%2C+Stanislaw%3BKordek%2C+Radzislaw%3BKalaylioglu%2C+Zynep%3BHarigopal%2C+Malini%3BCharrette%2C+Lori%3BFalk%2C+Roni+T%3BRichesson%2C+Douglas%3BAnderson%2C+William+F%3BHewitt%2C+Stephen+M%3BGarcia-Closas%2C+Montserrat&rft.aulast=Sherman&rft.aufirst=Mark&rft.date=2007-09-01&rft.volume=121&rft.issue=5&rft.spage=1079&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22812 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Etiology; Mathematical models; ErbB-2 protein; Post-menopause; Regression analysis; Statistical analysis; Breast cancer; Immunofluorescence; Tumors; Body mass index; Hormones; Models; post-menopause; body mass; Poland DO - http://dx.doi.org/10.1002/ijc.22812 ER - TY - JOUR T1 - Sorting of transgenic secretory proteins in miniature pig parotid glands following adenoviral-mediated gene transfer AN - 20645529; 8029077 AB - Background Gene transfer to salivary glands for use in treating both systemic and upper gastrointestinal tract diseases shows considerable potential. Numerous studies in rodents demonstrate that salivary glands can secrete transgenic secretory proteins either into saliva, primarily via the regulated secretory pathway (RSP), or into the bloodstream, primarily by the constitutive secretory pathway (CSP). The purpose of the present study was to assess the sorting characteristics of human growth hormone (hGH), a RSP protein, and human erythropoietin (hEpo), a CSP protein, in a large animal model of salivary gland gene transfer, the miniature pig. Methods Recombinant serotype 5 adenoviral (Ad5; 1011 particles/gland) vectors encoding either hGH (AdCMVhGH) or hEpo (AdCMVhEpo) were administered to both parotid glands of male miniature pigs by intraductal cannulation. The secretion of hGH or hEpo was measured in both saliva and serum on days 3, 7 and 14 following administration. Detailed serum chemistry and hematological analyses were performed, and the presence of serum antibodies to hGH and hEpo was measured. For AdCMVhEpo-treated minipigs vector distribution in multiple tissues was determined by quantitative polymerase chain reaction (QPCR). Results The RSP protein hGH was secreted entirely into saliva, while the CSP protein hEpo was secreted into both saliva and serum. Most hEpo was found in saliva, but serum hEpo levels were sufficient to significantly increase hematocrit levels in treated animals by 10%. Expression of both transgenes was maximal on day 3 and declined to near background by day 14. The amount of vector found in the targeted glands was 100X more than in other tissues. Conclusions Secretion of transgenic hGH from minipig parotid glands occurred principally into saliva via the RSP, as seen in rodents, while hEpo was secreted into both saliva and serum, the latter presumably via the CSP. Even though hEpo secretion into the bloodstream was not to the extent previously observed in rodents, serum hEpo levels were considerable and the hEpo was biologically active. Ad5 vector distribution was highly restricted to the parotid glands with little vector detected elsewhere. While the results in this large animal model support the established notion that salivary gland gene transfer can be used for treating systemic single protein deficiency disorders, they also highlight differences in transgenic CSP protein sorting between rodents and miniature pigs. JF - Journal of Gene Medicine AU - Yan, Xing AU - Voutetakis, Antonis AU - Zheng, Changyu AU - Hai, Bo AU - Zhang, Chunmei AU - Baum, Bruce J AU - Wang, Songlin AD - Salivary Gland Disease Center and the Molecular Laboratory for Gene Therapy, School of Stomatology, Capital Medical University, Beijing 100050, P.R. China, bbaum@dir.nidcr.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 779 EP - 787 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 9 IS - 9 SN - 1099-498X, 1099-498X KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Growth hormone KW - Serotypes KW - Gastrointestinal tract diseases KW - Secretion KW - Parotid gland KW - Animal models KW - CSP protein KW - Salivary gland KW - Expression vectors KW - Antibodies KW - Erythropoietin KW - Gene transfer KW - Protein deficiency KW - Hematocrit KW - Polymerase chain reaction KW - Saliva KW - Cannulation KW - W 30925:Genetic Engineering KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20645529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=A+pharmacokinetic+and+safety+evaluation+of+an+episcleral+cyclosporine+implant+for+potential+use+in+high-risk+keratoplasty+rejection.&rft.au=Lee%2C+Susan+S%3BKim%2C+Hyuncheol%3BWang%2C+Nam+Sun%3BBungay%2C+Peter+M%3BGilger%2C+Brian+C%3BYuan%2C+Peng%3BKim%2C+Jonghyeon%3BCsaky%2C+Karl+G%3BRobinson%2C+Michael+R&rft.aulast=Lee&rft.aufirst=Susan&rft.date=2007-05-01&rft.volume=48&rft.issue=5&rft.spage=2023&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=01460404&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Growth hormone; Serotypes; Secretion; Gastrointestinal tract diseases; Parotid gland; CSP protein; Animal models; Salivary gland; Expression vectors; Antibodies; Erythropoietin; Gene transfer; Protein deficiency; Polymerase chain reaction; Hematocrit; Saliva; Cannulation DO - http://dx.doi.org/10.1002/jgm.1081 ER - TY - JOUR T1 - Phosphoproteomics for the discovery of kinases as cancer biomarkers and drug targets AN - 20634983; 7732069 AB - Early detection and targeted therapy represent a novel regimen of cancer management The understanding of receptor tyrosine kinases in tumorigenesis at the molecular level has led to the first generation of kinase inhibitors for anticancer therapy that targets a specific kinase or pathway. While the therapeutic advantage is obvious, targeted therapy often relapses and results in drug resistance for advanced cancers. To achieve feasible early detection and better efficacy of therapeutics targeting multiple pathways, significantly more biomarkers and drug targets are in demand, especially for individualized therapy. Recent advances in phosphoprotein enrichment and MS technologies for quantitative phosphoproteome analysis provide great opportunities in the identification and validation of kinases as drug targets. The MS-based phosphoproteomic technologies would be useful tools as well for the identification of phosphosignatures unique to a specific type or subtype of cancer and drug responsive biomarkers. This review summarizes the major kinases acting as cancer biomarkers and drug targets, the advances of MS-based phosphoproteomic technologies, and some potential values and challenges of this emerging phos-phoproteomics-based biomarker and drug target discovery field. Strategies for global, targeted, and quantitative phosphoproteomics are discussed, and some recent interesting applications are also evaluated. JF - Proteomics Clinical Applications AU - Yu, L-R AU - Issaq, HJ AU - Veenstra, T D AD - SAIC-Frederick, Inc., NCI-Frederick, P.O. Box B, Bldg. 434, Rm. 5E, Frederick, MD 21702, USA, lyu@ncifcrf.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 1042 EP - 1057 VL - 1 IS - 9 SN - 1862-8346, 1862-8346 KW - Biotechnology Research Abstracts (through 1992) KW - Drug discovery KW - Phosphoproteins KW - Drug resistance KW - Reviews KW - Tumorigenesis KW - phosphoproteomes KW - Protein-tyrosine kinase receptors KW - proteomics KW - biomarkers KW - Cancer KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20634983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics+Clinical+Applications&rft.atitle=Phosphoproteomics+for+the+discovery+of+kinases+as+cancer+biomarkers+and+drug+targets&rft.au=Yu%2C+L-R%3BIssaq%2C+HJ%3BVeenstra%2C+T+D&rft.aulast=Yu&rft.aufirst=L-R&rft.date=2007-09-01&rft.volume=1&rft.issue=9&rft.spage=1042&rft.isbn=&rft.btitle=&rft.title=Proteomics+Clinical+Applications&rft.issn=18628346&rft_id=info:doi/10.1002%2Fprca.200700102 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - biomarkers; Cancer; Drug discovery; Reviews; Protein-tyrosine kinase receptors; proteomics; Tumorigenesis; phosphoproteomes; Phosphoproteins; Drug resistance DO - http://dx.doi.org/10.1002/prca.200700102 ER - TY - JOUR T1 - Risk of Testicular Germ Cell Cancer in Relation to Childhood Physical Activity AN - 20559763; 9271161 JF - Annals of Epidemiology AU - Cook, M B AU - Zhang, Y AU - Graubard, B I AU - Rubertone, M V AU - Erickson, R L AU - McGlynn, K A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 748 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 17 IS - 9 SN - 1047-2797, 1047-2797 KW - Physical Education Index KW - Epidemiology KW - Exercise KW - Cancer KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20559763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Biliary+tract+cancer+and+stones+in+relation+to+chronic+liver+conditions%3A+A+population-based+study+in+Shanghai%2C+China&rft.au=Hsing%2C+Ann+W%3BGao%2C+Yu-Tang%3BMcGlynn%2C+Katherine+A%3BNiwa%2C+Shelley%3BZhang%2C+Mingdong%3BHan%2C+Tian-Quan%3BWang%2C+Bing-Sheng%3BChen%2C+Jinbo%3BSakoda%2C+Lori+C%3BShen%2C+Ming-Chang%3BZhang%2C+Bai-He%3BDeng%2C+Jie%3BRashid%2C+Asif&rft.aulast=Hsing&rft.aufirst=Ann&rft.date=2007-05-01&rft.volume=120&rft.issue=9&rft.spage=1981&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22375 LA - English DB - Physical Education Index N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Epidemiology; Exercise; Cancer ER - TY - JOUR T1 - Rac interacts with Abi-1 and WAVE2 to promote an Arp23-dependent actin recruitment during chlamydial invasion AN - 20552171; 7894428 AB - Chlamydiae are Gram-negative obligate intracellular pathogens to which access to an intracellular environment is fundamental to their development. Chlamydial attachment to host cells induces the activation of the Rac GTPase, which is required for the localization of WAVE2 at the sites of chlamydial entry. Co-immunoprecipitation experiments demonstrated that Chlamydia trachomatis infection promoted the interaction of Rac with WAVE2 and Abi-1, but not with IRSp53. siRNA depletion of WAVE2 and Abi-1 abrogated chlamydia-induced actin recruitment and significantly reduced the uptake of the pathogen by the depleted cells. Chlamydia invasion also requires the Arp23 complex as demonstrated by its localization to the sites of chlamydial attachment and the reduced efficiency of chlamydial invasion in cells overexpressing the VCA domain of the neural Wiskott-Aldrich syndrome protein. Thus, C. trachomatis activates Rac and promotes its interaction with WAVE2 and Abi-1 to activate the Arp23 complex resulting in the induction of actin cytoskeletal rearrangements that are required for invasion. JF - Cellular Microbiology AU - Carabeo, Rey A AU - Dooley, Cheryl A AU - Grieshaber, Scott S AU - Hackstadt, Ted AD - Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY, USA., Ted_Hackstadt@NIH.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 2278 EP - 2288 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 9 IS - 9 SN - 1462-5814, 1462-5814 KW - Microbiology Abstracts B: Bacteriology KW - Cytoskeleton KW - siRNA KW - N-WASP protein KW - Chlamydia trachomatis KW - Actin KW - Pathogens KW - Development KW - Infection KW - Guanosinetriphosphatase KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20552171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+Microbiology&rft.atitle=Rac+interacts+with+Abi-1+and+WAVE2+to+promote+an+Arp23-dependent+actin+recruitment+during+chlamydial+invasion&rft.au=Carabeo%2C+Rey+A%3BDooley%2C+Cheryl+A%3BGrieshaber%2C+Scott+S%3BHackstadt%2C+Ted&rft.aulast=Carabeo&rft.aufirst=Rey&rft.date=2007-09-01&rft.volume=9&rft.issue=9&rft.spage=2278&rft.isbn=&rft.btitle=&rft.title=Cellular+Microbiology&rft.issn=14625814&rft_id=info:doi/10.1111%2Fj.1462-5822.2007.00958.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cytoskeleton; siRNA; N-WASP protein; Actin; Development; Pathogens; Infection; Guanosinetriphosphatase; Chlamydia trachomatis DO - http://dx.doi.org/10.1111/j.1462-5822.2007.00958.x ER - TY - JOUR T1 - Process optimization of large-scale production of recombinant adeno-associated vectors using dielectric spectroscopy AN - 20522365; 7623482 AB - A well-characterized manufacturing process for the large-scale production of recombinant adeno-associated vectors (rAAV) for gene therapy applications is required to meet current and future demands for pre-clinical and clinical studies and potential commercialization. Economic considerations argue in favor of suspension culture-based production. Currently, the only feasible method for large-scale rAAV production utilizes baculovirus expression vectors and insect cells in suspension cultures. To maximize yields and achieve reproducibility between batches, online monitoring of various metabolic and physical parameters is useful for characterizing early stages of baculovirus-infected insect cells. In this study, rAAVs were produced at 40-l scale yielding ~1 x 10 super(15) particles. During the process, dielectric spectroscopy was performed by real time scanning in radio frequencies between 300 kHz and 10 MHz. The corresponding permittivity values were correlated with the rAAV production. Both infected and uninfected reached a maximum value; however, only infected cell cultures permittivity profile reached a second maximum value. This effect was correlated with the optimal harvest time for rAAV production. Analysis of rAAV indicated the harvesting time around 48 h post-infection (hpi), and 72 hpi produced similar quantities of biologically active rAAV. Thus, if operated continuously, the 24-h reduction in the production process of rAAV gives sufficient time for additional 18 runs a year corresponding to an extra production of ~2 x 10 super(16) particles. As part of large-scale optimization studies, this new finding will facilitate the bioprocessing scale-up of rAAV and other bioproducts. JF - Applied Microbiology and Biotechnology AU - Negrete, Alejandro AU - Esteban, Geoffrey AU - Kotin, Robert M AD - US National Institutes of Health, 10 Center Drive, NIH, Building 10, Room 7D05, Bethesda, MD, 20892, USA, kotinr@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 761 EP - 772 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 76 IS - 4 SN - 0175-7598, 0175-7598 KW - Biotechnology and Bioengineering Abstracts KW - Expression vectors KW - Scanning KW - Gene therapy KW - Insect cells KW - Economics KW - Cell culture KW - Suspension culture KW - Baculovirus KW - Spectroscopy KW - Harvesting KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20522365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Microbiology+and+Biotechnology&rft.atitle=Process+optimization+of+large-scale+production+of+recombinant+adeno-associated+vectors+using+dielectric+spectroscopy&rft.au=Negrete%2C+Alejandro%3BEsteban%2C+Geoffrey%3BKotin%2C+Robert+M&rft.aulast=Negrete&rft.aufirst=Alejandro&rft.date=2007-09-01&rft.volume=76&rft.issue=4&rft.spage=761&rft.isbn=&rft.btitle=&rft.title=Applied+Microbiology+and+Biotechnology&rft.issn=01757598&rft_id=info:doi/10.1007%2Fs00253-007-1030-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Expression vectors; Gene therapy; Scanning; Insect cells; Economics; Suspension culture; Cell culture; Spectroscopy; Harvesting; Baculovirus DO - http://dx.doi.org/10.1007/s00253-007-1030-9 ER - TY - JOUR T1 - Aegyptin, a Novel Mosquito Salivary Gland Protein, Specifically Binds to Collagen and Prevents Its Interaction with Platelet Glycoprotein VI, Integrin alpha 2 beta 1, and von Willebrand Factor AN - 20463564; 7613880 AB - Blood-sucking arthropods have evolved a number of inhibitors of platelet aggregation and blood coagulation. In this study we have molecularly and functionally characterized aegyptin, a member of the family of 30-kDa salivary allergens from Aedes aegypti, whose function remained elusive thus far. Aegyptin displays a unique sequence characterized by glycine, glutamic acid, and aspartic acid repeats and was shown to specifically block collagen-induced human platelet aggregation and granule secretion. Plasmon resonance experiments demonstrate that aegyptin binds to collagen types I-V (K sub(d) approximately 1 nM) but does not interact with vitronectin, fibronectin, laminin, fibrinogen, and von Willebrand factor (vWf). In addition, aegyptin attenuates platelet adhesion to soluble or fibrillar collagen. Furthermore, aegyptin inhibits vWf interaction with collagen type III under static conditions and completely blocks platelet adhesion to collagen under flow conditions at high shear rates. Notably, aegyptin prevents collagen but not convulxin binding to recombinant glycoprotein VI. These findings suggest that aegyptin recognizes specific binding sites for glycoprotein VI, integrin alpha 2 beta 1, and vWf, thereby preventing collagen interaction with its three major ligands. Aegyptin is a novel tool to study collagen-platelet interaction and a prototype for development of molecules with antithrombotic properties. JF - Journal of Biological Chemistry AU - Calvo, Eric AU - Tokumasu, Fuyuki AU - Marinotti, Osvaldo AU - Villeval, Jean-Luc AU - Ribeiro, Jose MC AU - Francischetti, Ivo MB AD - Vector Biology Section, and Biochemical and Biophysical Parasitology Section, Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Bethesda, Maryland 20892-8132, the Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697-3900, and INSERM, U790, Universite Paris XI, Institut Gustave Roussy, 94805 Villejuif, France Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 26928 EP - 26938 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org] VL - 282 IS - 37 SN - 0021-9258, 0021-9258 KW - Yellow fever mosquito KW - Entomology Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Aedes aegypti KW - Von Willebrand factor KW - Aspartic acid KW - Platelet aggregation KW - Secretion KW - Collagen KW - Public health KW - Recombinants KW - Arthropoda KW - Integrins KW - glycoprotein VI KW - Allergens KW - Glands KW - vitronectin KW - Glycoproteins KW - Aquatic insects KW - Ligands KW - Q1 08306:Physiology, biochemistry, biophysics KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20463564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Aegyptin%2C+a+Novel+Mosquito+Salivary+Gland+Protein%2C+Specifically+Binds+to+Collagen+and+Prevents+Its+Interaction+with+Platelet+Glycoprotein+VI%2C+Integrin+alpha+2+beta+1%2C+and+von+Willebrand+Factor&rft.au=Calvo%2C+Eric%3BTokumasu%2C+Fuyuki%3BMarinotti%2C+Osvaldo%3BVilleval%2C+Jean-Luc%3BRibeiro%2C+Jose+MC%3BFrancischetti%2C+Ivo+MB&rft.aulast=Calvo&rft.aufirst=Eric&rft.date=2007-09-01&rft.volume=282&rft.issue=37&rft.spage=26928&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Recombinants; Secretion; Glands; Glycoproteins; Aquatic insects; Ligands; Public health; Von Willebrand factor; Aspartic acid; Integrins; Platelet aggregation; Allergens; glycoprotein VI; vitronectin; Collagen; Aedes aegypti; Arthropoda ER - TY - JOUR T1 - Role of the Proteasome in Ethanol-Induced Liver Pathology AN - 20418895; 7883795 AB - The ubiquitin-proteasome system has come to be known as a vital constituent of mammalian cells. The proteasome is a large nonlysosomal enzyme that acts in concert with an 8.5 kDa polypeptide called ubiquitin and a series of conjugating enzymes, known as E1, E2 and E3, that covalently bind multiple ubiquitin moieties in a polyubiquitin chain to protein substrates in a process called ubiquitylation. The latter process targets protein substrates for unfolding and degradation by the 26S proteasome. This enzyme system specifically recognizes and degrades polyubiquitylated proteins, many of which are key proteins involved in cell cycle regulation, apoptosis, signal transduction, and antigen presentation. The 26S proteasome contains a cylinder-shaped 20S catalytic core that, itself, degrades proteins in an ATP- and ubiquitin-independent manner. The 20S form is actually the predominant enzyme form in mammalian cells. Proteolysis by the constitutive 20S proteasome is vital in removing oxidized, misfolded and otherwise modified proteins. Such degradation is critical as a means of cellular detoxification, as intracellular accumulation of damaged and misfolded proteins is potentially lethal. Studies have shown that inhibition of proteasome activity can lead to cell death. Ethanol and its metabolism cause partial inhibition of the proteasome. This leads to a number of pleiotropic effects that can affect a variety of cellular processes. This critical review describes important aspects of ethanol metabolism and its influence on the proteasome. The review will summarize recent findings on: (1) the interactions between the proteasome and the ethanol metabolizing enzyme, CYP2E1; (2) the dynamics of proteasome inhibition by ethanol in animal models and cultured cells; (3) ethanol-elicited suppression of proteasome activity and its effect on signal transduction; (4) The role of proteasome inhibition in cytokine production by liver cells; and (5) ethanol elicited suppression of peptide hydrolysis and the potential effects on antigen presentation. While the principal focus is on alcohol-induced liver injury, the authors foresee that the findings presented in this review will prompt further research on the role of this proteolytic system in other tissues injured by excessive alcohol consumption. JF - Alcoholism: Clinical and Experimental Research AU - Donohue, Terrence M AU - Cederbaum, Arthur I AU - French, Samuel W AU - Barve, Shirish AU - Gao, Bin AU - Osna, Natalia A AD - From the Liver Study Unit Omaha VA Medical Center, and Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska (TMD, NAO); Departments of Pharmacology and Biological Chemistry, Mt. Sinai Medical Center, New York, New York (AIC); Department of Anatomic Pathology Harbor UCLA Medical Center, Torrance, California (SWF); Department of Internal Medicine, University of Louisville Medical Center, Louisville, Kentucky (SB); and Section of Liver Biology, National Institutes of Health, Bethesda, Maryland (BG). Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 1446 EP - 1459 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 31 IS - 9 SN - 0145-6008, 0145-6008 KW - Toxicology Abstracts KW - Ethanol Metabolism KW - Proteolysis KW - Ubiquitin Proteasome System KW - Alcoholic Liver Disease KW - Signal Transduction KW - Antigen Presentation KW - Detoxification KW - Apoptosis KW - Injuries KW - Hepatocytes KW - Cell cycle KW - proteasomes KW - Animal models KW - Enzymes KW - Antigen presentation KW - Drug abuse KW - Hydrolysis KW - Mammalian cells KW - Protein folding KW - Reviews KW - Alcoholism KW - Liver KW - Cytokines KW - Metabolism KW - Signal transduction KW - Ubiquitin KW - Ethanol KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20418895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%3A+Clinical+and+Experimental+Research&rft.atitle=Role+of+the+Proteasome+in+Ethanol-Induced+Liver+Pathology&rft.au=Donohue%2C+Terrence+M%3BCederbaum%2C+Arthur+I%3BFrench%2C+Samuel+W%3BBarve%2C+Shirish%3BGao%2C+Bin%3BOsna%2C+Natalia+A&rft.aulast=Donohue&rft.aufirst=Terrence&rft.date=2007-09-01&rft.volume=31&rft.issue=9&rft.spage=1446&rft.isbn=&rft.btitle=&rft.title=Alcoholism%3A+Clinical+and+Experimental+Research&rft.issn=01456008&rft_id=info:doi/10.1111%2Fj.1530-0277.2007.00454.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Detoxification; Proteolysis; Apoptosis; Injuries; Hepatocytes; Cell cycle; Animal models; proteasomes; Enzymes; Drug abuse; Antigen presentation; Hydrolysis; Protein folding; Mammalian cells; Reviews; Alcoholism; Liver; Cytokines; Metabolism; Ethanol; Ubiquitin; Signal transduction DO - http://dx.doi.org/10.1111/j.1530-0277.2007.00454.x ER - TY - JOUR T1 - Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy AN - 20410111; 7636230 AB - Annexin V and Sytox Green are widely used markers to evaluate apoptosis in various cell types using flow cytometry and fluorescent microscopy. Recently, a novel fluoroprobe MitoSOX Red was introduced for selective detection of superoxide in the mitochondria of live cells and was validated for confocal microscopy and flow cytometry. This protocol describes simultaneous measurements of mitochondrial superoxide generation with apoptotic markers (Annexin V and Sytox Green) by both flow cytometry and confocal microscopy in endothelial cell lines. The advantages of the described flow cytometry method over other cell-based techniques are the tremendous speed (1-2 h), exquisite precision and the possibility of simultaneous quantitative measurements of mitochondrial superoxide generation and apoptotic (and other) markers, with maximal preservation of cellular functions. This method combined with fluorescent microscopy may be very useful to reveal important spatial-temporal changes in mitochondrial superoxide production and execution of programmed cell death in virtually any cell type. JF - Nature Protocols AU - Mukhopadhyay, Partha AU - Rajesh, Mohanraj AU - Hasko, Gyoergy AU - Hawkins, Brian J AU - Madesh, Muniswamy AU - Pacher, Pal Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 2295 EP - 2301 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 2 IS - 9 SN - 1754-2189, 1754-2189 KW - Biotechnology Research Abstracts (through 1992) KW - Endothelial cells KW - Flow cytometry KW - Apoptosis KW - Superoxide KW - Confocal microscopy KW - Mitochondria KW - Preservation KW - Annexin V KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20410111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Protocols&rft.atitle=Simultaneous+detection+of+apoptosis+and+mitochondrial+superoxide+production+in+live+cells+by+flow+cytometry+and+confocal+microscopy&rft.au=Mukhopadhyay%2C+Partha%3BRajesh%2C+Mohanraj%3BHasko%2C+Gyoergy%3BHawkins%2C+Brian+J%3BMadesh%2C+Muniswamy%3BPacher%2C+Pal&rft.aulast=Mukhopadhyay&rft.aufirst=Partha&rft.date=2007-09-01&rft.volume=2&rft.issue=9&rft.spage=2295&rft.isbn=&rft.btitle=&rft.title=Nature+Protocols&rft.issn=17542189&rft_id=info:doi/10.1038%2Fnprot.2007.327 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Mitochondria; Apoptosis; Superoxide; Confocal microscopy; Annexin V; Preservation; Endothelial cells DO - http://dx.doi.org/10.1038/nprot.2007.327 ER - TY - JOUR T1 - Effects of manganese on thyroid hormone homeostasis: Potential links AN - 20405765; 7750857 AB - Manganese (Mn) is an essential trace nutrient that is potentially toxic at high levels of exposure. As a constituent of numerous enzymes and a cofactor, manganese plays an important role in a number of physiologic processes in mammals. The manganese-containing enzyme, manganese superoxide dismutase (Mn-SOD), is the principal antioxidant enzyme which neutralizes the toxic effects of reactive oxygen species. Other manganese-containing enzymes include oxidoreductases, transferases, hydrolases, lyases, isomerases, ligases and glutamine synthetase. Environmental or occupational exposure to high levels of manganese can cause a neuropathy resembling idiopathic Parkinson's disease, commonly referred to as manganism. Manganism and Parkinson's disease are both characterized by motor deficits and damage to nuclei of the basal ganglia, particularly the substantia nigra, with altered dopamine (and its metabolites) contributing to these disorders. Dopamine, a major neurotransmitter plays a crucial role in the modulation of the cognitive function, working memory and/or attention of the prefrontal cortex and the hippocampus. Dopamine is also a known inhibitory modulator of thyroid stimulating hormone (TSH) secretion. The involvement of dopamine and dopaminergic receptors in neurodevelopment, as well as TSH modulation, led us to hypothesize that excessive manganese exposure may lead to adverse neurodevelopmental outcomes due to the disruption of thyroid homeostasis via the loss of dopaminergic control of TSH regulation of thyroid hormones. This disruption may alter thyroid hormone levels, resulting in some of the deficits associated with gestational exposure to manganese. While the effects of manganese in adult populations are relatively well documented, comprehensive data on its neurodevelopmental effects are sparse. Given the importance of this topic, we review the potential participation of thyroid hormone dyshomeostasis in the neurodevelopmental effects of manganese positing the hypotheses that manganese may directly or indirectly affect thyroid function by injuring the thyroid gland or dysregulating dopaminergic modulation of thyroid hormone synthesis. JF - Neurotoxicology AU - Soldin, O P AU - Aschner, M AD - The Center for Study of Sex Differences, Georgetown University Medical Center, Washington, DC, and Obstetrics Pharmacology Research Unit, NICHD, USA, os35@georgetown.edu Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 951 EP - 956 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 28 IS - 5 SN - 0161-813X, 0161-813X KW - Health & Safety Science Abstracts; CSA Neurosciences Abstracts; Toxicology Abstracts KW - Antioxidants KW - Hippocampus KW - Parkinson's disease KW - Secretion KW - Nutrients KW - Metabolites KW - Homeostasis KW - Hormones KW - Short term memory KW - Thyroid hormones KW - Neuromodulation KW - Dopamine KW - Superoxide dismutase KW - Thyroid-stimulating hormone KW - Neurotransmitters KW - Manganese KW - Occupational exposure KW - Neuropathy KW - mammals KW - Substantia nigra KW - Thyroid KW - Enzymes KW - Toxicity KW - Glutamate-ammonia ligase KW - hydrolase KW - Oxygen KW - Neurodegenerative diseases KW - cognitive ability KW - Movement disorders KW - Cofactors KW - Cognitive ability KW - Reviews KW - oxidoreductase KW - Attention KW - Cortex (prefrontal) KW - Basal ganglia KW - N3 11028:Neuropharmacology & toxicology KW - H 1000:Occupational Safety and Health KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20405765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Effects+of+manganese+on+thyroid+hormone+homeostasis%3A+Potential+links&rft.au=Soldin%2C+O+P%3BAschner%2C+M&rft.aulast=Soldin&rft.aufirst=O&rft.date=2007-09-01&rft.volume=28&rft.issue=5&rft.spage=951&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2007.05.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Antioxidants; Hippocampus; Secretion; Parkinson's disease; Metabolites; Nutrients; Homeostasis; Short term memory; Thyroid hormones; Neuromodulation; Dopamine; Superoxide dismutase; Neurotransmitters; Thyroid-stimulating hormone; Manganese; Occupational exposure; Neuropathy; Substantia nigra; Enzymes; hydrolase; Glutamate-ammonia ligase; Neurodegenerative diseases; Cofactors; Movement disorders; Cognitive ability; Reviews; oxidoreductase; Attention; Basal ganglia; Cortex (prefrontal); mammals; Thyroid; Toxicity; Hormones; Oxygen; cognitive ability DO - http://dx.doi.org/10.1016/j.neuro.2007.05.003 ER - TY - JOUR T1 - Analysis of inflammatory biomarkers from tissue biopsies by chip-based immunoaffinity CE AN - 20402942; 7762902 AB - To aid in the biochemical analysis of human skin biopsies, a semiautomatic chip-based CE system has been developed for measuring inflammatory biomarkers in microdissected areas of the biopsy. Following solubilization of the dissected tissue, the desired biomarkers were isolated by immunoaffinity capture using a panel of 12 antibodies, immobilized on a disposable glass fiber disk, within the extraction port of the chip. The captured analytes were labeled with a 635nm light-emitting laser dye and electroeluted into the separation channel. Electrophoretic separation of all of the analytes was achieved in 2.2min with quantification of each peak being performed by online LIF detection and integration of each peak area. Comparison of the results obtained from the chip-based system to those obtained using commercially available high-sensitivity immunoassays demonstrated that the chip-based assay provides a fast, accurate procedure for studying the concentrations of inflammatory biomarkers in complex biological materials. The degree of accuracy and precision achieved by the chip-based CE is comparable to conventional immunoassays and the system is capable of analyzing circa six samples per hour. With the ever-expanding array of antibodies that are commercially available, this chip-based system can be applied to a wide variety of different biomedical analyses. JF - Electrophoresis AU - Phillips, Terry M AU - Wellner, Edward F AD - Nanoscale Immunodiagnostics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA, phillipt@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 3041 EP - 3048 PB - Wiley-VCH, Postfach 101161 Weinheim 69451 Germany, [mailto:info@wiley-vch.de], [URL:http://www.wiley-vch.de/publish/en/] VL - 28 IS - 17 SN - 0173-0835, 0173-0835 KW - Biotechnology and Bioengineering Abstracts KW - Fibers KW - Integration KW - Antibodies KW - Skin KW - Solubilization KW - Biochemical analysis KW - Lasers KW - Biopsy KW - Immunoassays KW - biomarkers KW - Inflammation KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20402942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Electrophoresis&rft.atitle=Analysis+of+inflammatory+biomarkers+from+tissue+biopsies+by+chip-based+immunoaffinity+CE&rft.au=Phillips%2C+Terry+M%3BWellner%2C+Edward+F&rft.aulast=Phillips&rft.aufirst=Terry&rft.date=2007-09-01&rft.volume=28&rft.issue=17&rft.spage=3041&rft.isbn=&rft.btitle=&rft.title=Electrophoresis&rft.issn=01730835&rft_id=info:doi/10.1002%2Felps.200700193 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - biomarkers; Biopsy; Inflammation; Antibodies; Immunoassays; Lasers; Biochemical analysis; Skin; Solubilization; Integration; Fibers DO - http://dx.doi.org/10.1002/elps.200700193 ER - TY - JOUR T1 - Potent Inhibition of HIV-1 Replication by Novel Non-peptidyl Small Molecule Inhibitors of Protease Dimerization AN - 20363392; 7614068 AB - Dimerization of HIV-1 protease subunits is essential for its proteolytic activity, which plays a critical role in HIV-1 replication. Hence, the inhibition of protease dimerization represents a unique target for potential intervention of HIV-1. We developed an intermolecular fluorescence resonance energy transfer-based HIV-1-expression assay employing cyan and yellow fluorescent protein-tagged protease monomers. Using this assay, we identified non-peptidyl small molecule inhibitors of protease dimerization. These inhibitors, including darunavir and two experimental protease inhibitors, blocked protease dimerization at concentrations of as low as 0.01 mu M and blocked HIV-1 replication with IC sub(50) values of 0.0002-0.48 mu M. These agents also inhibited the proteolytic activity of mature protease. Other approved anti-HIV-1 agents examined except tipranavir, a CCR5 inhibitor, and soluble CD4 failed to block the dimerization event. Once protease monomers dimerize to become mature protease, mature protease is not dissociated by this dimerization inhibition mechanism, suggesting that these agents block dimerization at the nascent stage of protease maturation. The proteolytic activity of mature protease that managed to undergo dimerization despite the presence of these agents is likely to be inhibited by the same agents acting as conventional protease inhibitors. Such a dual inhibition mechanism should lead to highly potent inhibition of HIV-1. JF - Journal of Biological Chemistry AU - Koh, Yasuhiro AU - Matsumi, Shintaro AU - Das, Debananda AU - Amano, Masayuki AU - Davis, David A AU - Li, Jianfeng AU - Leschenko, Sofiya AU - Baldridge, Abigail AU - Shioda, Tatsuo AU - Yarchoan, Robert AU - Ghosh, Arun K AU - Mitsuya, Hiroaki AD - Department of Hematology and Department of Infectious Diseases, Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, 1-1-1 Honjo, Kumamoto 860-8556, Japan, the Experimental Retrovirology Section and Retroviral Disease Section, HIV and AIDS Malignancy Branch, NCI, National Institutes of Health, Bethesda, Maryland 20892, the Departments of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907, and the Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 28709 EP - 28720 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 39 SN - 0021-9258, 0021-9258 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Proteolysis KW - Fluorescence KW - Replication KW - Proteinase inhibitors KW - CCR5 protein KW - Monomers KW - CD4 antigen KW - Human immunodeficiency virus 1 KW - V 22360:AIDS and HIV KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20363392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Potent+Inhibition+of+HIV-1+Replication+by+Novel+Non-peptidyl+Small+Molecule+Inhibitors+of+Protease+Dimerization&rft.au=Koh%2C+Yasuhiro%3BMatsumi%2C+Shintaro%3BDas%2C+Debananda%3BAmano%2C+Masayuki%3BDavis%2C+David+A%3BLi%2C+Jianfeng%3BLeschenko%2C+Sofiya%3BBaldridge%2C+Abigail%3BShioda%2C+Tatsuo%3BYarchoan%2C+Robert%3BGhosh%2C+Arun+K%3BMitsuya%2C+Hiroaki&rft.aulast=Koh&rft.aufirst=Yasuhiro&rft.date=2007-09-01&rft.volume=282&rft.issue=39&rft.spage=28709&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus 1; Proteinase inhibitors; Replication; Proteolysis; Monomers; CD4 antigen; Fluorescence; CCR5 protein ER - TY - JOUR T1 - Characterization of Chimpanzee/Human Monoclonal Antibodies to Vaccinia Virus A33 Glycoprotein and Its Variola Virus Homolog In Vitro and in a Vaccinia Virus Mouse Protection Model AN - 20356285; 7559260 AB - Three distinct chimpanzee Fabs against the A33 envelope glycoprotein of vaccinia virus were isolated and converted into complete monoclonal antibodies (MAbs) with human gamma 1 heavy-chain constant regions. The three MAbs (6C, 12C, and 12F) displayed high binding affinities to A33 (K sub(d) of 0.14 nM to 20 nM) and may recognize the same epitope, which was determined to be conformational and located within amino acid residues 99 to 185 at the C terminus of A33. One or more of the MAbs were shown to reduce the spread of vaccinia virus as well as variola virus (the causative agent of smallpox) in vitro and to more effectively protect mice when administered before or 2 days after intranasal challenge with virulent vaccinia virus than a previously isolated mouse anti-A33 MAb (1G10) or vaccinia virus immunoglobulin. The protective efficacy afforded by anti-A33 MAb was comparable to that of a previously isolated chimpanzee/human anti-B5 MAb. The combination of anti-A33 MAb and anti-B5 MAb did not synergize the protective efficacy. These chimpanzee/human anti-A33 MAbs may be useful in the prevention and treatment of vaccinia virus-induced complications of vaccination against smallpox and may also be effective in the immunoprophylaxis and immunotherapy of smallpox and other orthopoxvirus diseases. JF - Journal of Virology AU - Chen, Zhaochun AU - Earl, Patricia AU - Americo, Jeffrey AU - Damon, Inger AU - Smith, Scott K AU - Yu, Fujuan AU - Sebrell, Andrew AU - Emerson, Suzanne AU - Cohen, Gary AU - Eisenberg, Roselyn J AU - Gorshkova, Inna AU - Schuck, Peter AU - Satterfield, William AU - Moss, Bernard AU - Purcell, Robert AD - Hepatitis Viruses Section. Molecular Hepatitis Section. Laboratory of Infectious Diseases, and Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases. Protein Biophysics Resource, National Institute for Biomedical Imaging and Bioengineering, NIH, Bethesda, Maryland 20892. Centers for Disease Control and Prevention, Atlanta, Georgia 30333. Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104. Department of Veterinary Sciences, University of Texas, M. D. Anderson Cancer Center, Bastrop, Texas 78602 Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - 8989 EP - 8995 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 81 IS - 17 SN - 0022-538X, 0022-538X KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Orthopoxvirus KW - Immunotherapy KW - Envelopes KW - Constant region KW - Glycoproteins KW - Immunoglobulins KW - Synergism KW - Amino acids KW - Vaccinia KW - Monoclonal antibodies KW - Vaccinia virus KW - Immunoprophylaxis KW - Animal models KW - Epitopes KW - Variola virus KW - Vaccination KW - Pan troglodytes KW - Smallpox KW - Fab KW - V 22410:Animal Diseases KW - W 30915:Pharmaceuticals & Vaccines KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20356285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Characterization+of+Chimpanzee%2FHuman+Monoclonal+Antibodies+to+Vaccinia+Virus+A33+Glycoprotein+and+Its+Variola+Virus+Homolog+In+Vitro+and+in+a+Vaccinia+Virus+Mouse+Protection+Model&rft.au=Chen%2C+Zhaochun%3BEarl%2C+Patricia%3BAmerico%2C+Jeffrey%3BDamon%2C+Inger%3BSmith%2C+Scott+K%3BYu%2C+Fujuan%3BSebrell%2C+Andrew%3BEmerson%2C+Suzanne%3BCohen%2C+Gary%3BEisenberg%2C+Roselyn+J%3BGorshkova%2C+Inna%3BSchuck%2C+Peter%3BSatterfield%2C+William%3BMoss%2C+Bernard%3BPurcell%2C+Robert&rft.aulast=Chen&rft.aufirst=Zhaochun&rft.date=2007-09-01&rft.volume=81&rft.issue=17&rft.spage=8989&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Vaccinia virus; Pan troglodytes; Variola virus; Orthopoxvirus; Monoclonal antibodies; Smallpox; Glycoproteins; Amino acids; Immunotherapy; Synergism; Fab; Immunoprophylaxis; Animal models; Epitopes; Vaccinia; Immunoglobulins; Constant region; Vaccination; Envelopes ER - TY - JOUR T1 - Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome AN - 20338177; 7616787 AB - Little is known about genetic regulation of the development of white matter. This knowledge is critical in understanding the pathophysiology of neurodevelopmental syndromes associated with altered cognition as well as in elucidating the genetics of normal human cognition. The hemideletion of approximately 25 genes on chromosome 7q11.23 that causes Williams syndrome (WS) includes genes that regulate cytoskeletal dynamics in neurons, especially LIMK1 and CYLN2, and therefore offers the opportunity to investigate the role of these genes in the formation of white matter tracts. We used diffusion tensor imaging to demonstrate alteration in white matter fiber directionality, deviation in posterior fiber tract course, and reduced lateralization of fiber coherence in WS. These abnormalities are consistent with an alteration of the late stages of neuronal migration, define alterations of white matter structures underlying dissociable behavioral phenotypes in WS, and provide human in vivo information about genetic control of white matter tract formation. JF - Proceedings of the National Academy of Sciences, USA AU - Marenco, Stefano AU - Siuta, Michael A AU - Kippenhan, JShane AU - Grodofsky, Samuel AU - Chang, Wei-li AU - Kohn, Philip AU - Mervis, Carolyn B AU - Morris, Colleen A AU - Weinberger, Daniel R AU - Meyer-Lindenberg, Andreas AU - Pierpaoli, Carlo AU - Berman, Karen Faith AD - Clinical Brain Disorders Branch (CBDB), Genes Cognition and Psychosis Program (GCAP), Intramural Research Program (IRP), National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Department of Health and Human Services, Bethesda, MD 20892 Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 15117 EP - 15122 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 38 SN - 0027-8424, 0027-8424 KW - CSA Neurosciences Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Neurodevelopmental disorders KW - Magnetic resonance imaging KW - LIM kinase KW - Substantia alba KW - Cognition KW - chromosome 7 KW - Cytoskeleton KW - Fibers KW - Neurons KW - Genetic control KW - Cell migration KW - Williams syndrome KW - W 30910:Imaging KW - N3 11023:Neurogenetics KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20338177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Genetic+contributions+to+white+matter+architecture+revealed+by+diffusion+tensor+imaging+in+Williams+syndrome&rft.au=Marenco%2C+Stefano%3BSiuta%2C+Michael+A%3BKippenhan%2C+JShane%3BGrodofsky%2C+Samuel%3BChang%2C+Wei-li%3BKohn%2C+Philip%3BMervis%2C+Carolyn+B%3BMorris%2C+Colleen+A%3BWeinberger%2C+Daniel+R%3BMeyer-Lindenberg%2C+Andreas%3BPierpaoli%2C+Carlo%3BBerman%2C+Karen+Faith&rft.aulast=Marenco&rft.aufirst=Stefano&rft.date=2007-09-01&rft.volume=104&rft.issue=38&rft.spage=15117&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cytoskeleton; Neurodevelopmental disorders; Fibers; Neurons; LIM kinase; Magnetic resonance imaging; Substantia alba; Genetic control; Cell migration; Williams syndrome; Cognition; chromosome 7 ER - TY - JOUR T1 - The Structure of the R184A Mutant of the Inositol Monophosphatase Encoded by suhB and Implications for Its Functional Interactions in Escherichia coli AN - 20334202; 7613887 AB - The Escherichia coli product of the suhB gene, SuhB, is an inositol monophosphatase (IMPase) that is best known as a suppressor of temperature-sensitive growth phenotypes in E. coli. To gain insights into these biological diverse effects, we determined the structure of the SuhB R184A mutant protein. The structure showed a dimer organization similar to other IMPases, but with an altered interface suggesting that the presence of Arg-184 in the wild-type protein could shift the monomer-dimer equilibrium toward monomer. In parallel, a gel shift assay showed that SuhB forms a tight complex with RNA polymerase (RNA pol) that inhibits the IMPase catalytic activity of SuhB. A variety of SuhB mutant proteins designed to stabilize the dimer interface did not show a clear correlation with the ability of a specific mutant protein to complement the Delta suhB mutation when introduced extragenically despite being active IMPases. However, the loss of sensitivity to RNA pol binding, i.e. in G173V, R184I, and L96F/R184I, did correlate strongly with loss of complementation of Delta suhB. Because residue 184 forms the core of the SuhB dimer, it is likely that the interaction with RNA polymerase requires monomeric SuhB. The exposure of specific residues facilitates the interaction of SuhB with RNA pol (or another target with a similar binding surface) and it is this heterodimer formation that is critical to the ability of SuhB to rescue temperature-sensitive phenotypes in E. coli. JF - Journal of Biological Chemistry AU - Wang, Yanling AU - Stieglitz, Kimberly A AU - Bubunenko, Mikhail AU - Court, Donald L AU - Stec, Boguslaw AU - Roberts, Mary F AD - Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, the Basic Research Program, SAIC-Frederick, Inc. and the Molecular Control and Genetics Section, Gene Regulation and Chromosome Biology Laboratory, Center for Cancer Research, NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702, and The Burnham Institute for Medical Research, La Jolla, California 92037 Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 26989 EP - 26996 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 37 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Myo-inositol-1 (or 4)-monophosphatase KW - Monomers KW - DNA-directed RNA polymerase KW - Complementation KW - Escherichia coli KW - Mutation KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20334202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=The+Structure+of+the+R184A+Mutant+of+the+Inositol+Monophosphatase+Encoded+by+suhB+and+Implications+for+Its+Functional+Interactions+in+Escherichia+coli&rft.au=Wang%2C+Yanling%3BStieglitz%2C+Kimberly+A%3BBubunenko%2C+Mikhail%3BCourt%2C+Donald+L%3BStec%2C+Boguslaw%3BRoberts%2C+Mary+F&rft.aulast=Wang&rft.aufirst=Yanling&rft.date=2007-09-01&rft.volume=282&rft.issue=37&rft.spage=26989&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Monomers; Myo-inositol-1 (or 4)-monophosphatase; DNA-directed RNA polymerase; Complementation; Mutation; Escherichia coli ER - TY - JOUR T1 - Serum 25(OH)-Vitamin D Concentration and Risk of Esophageal Squamous Dysplasia AN - 20328525; 7610363 AB - Background: Squamous dysplasia is the precursor lesion for esophageal squamous cell carcinoma, and nutritional factors play an important role in the etiology of this cancer. Previous studies using a variety of measures for vitamin D exposure have reached different conclusions about the association between vitamin D and the risk of developing esophageal cancer. Methods: We measured serum 25-hydroxyvitamin D [25(OH)D] concentrations in a cross-sectional analysis of 720 subjects from Linxian, China, a population at high risk for developing esophageal squamous cell carcinoma. All subjects underwent endoscopy and biopsy and were categorized by the presence or absence of histologic squamous dysplasia. We used crude and multivariate-adjusted generalized linear models to estimate the relative risks (RR) and 95% confidence intervals (95% CI) for the association between squamous dysplasia and sex-specific quartiles of serum 25(OH)D concentration. Results: Two-hundred and thirty of 720 subjects (32%) had squamous dysplasia. Subjects with dysplasia had significantly higher median serum 25(OH)D concentrations than subjects without dysplasia, 36.5 and 31.5 nmol/L, respectively (Wilcoxon two-sample test, P = 0.0004). In multivariate-adjusted models, subjects in the highest compared with the lowest quartiles were at a significantly increased risk of squamous dysplasia (RR, 1.86; 95% CI, 1.35-2.62). Increased risks were similar when examined in men and women separately: men (RR, 1.74; 95% CI, 1.08-2.93); women (RR, 1.96; 95% CI, 1.28-3.18). Conclusions: Higher serum 25(OH)D concentrations were associated with significantly increased risk of squamous dysplasia. No obvious source of measured or unmeasured confounding explains this finding. (Cancer Epidemiol Biomarkers Prev 2007; 16(9):1889-93) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Abnet, Christian C AU - Chen, Wen AU - Dawsey, Sanford M AU - Wei, Wen-Qiang AU - Roth, Mark J AU - Liu, Bing AU - Lu, Ning AU - Taylor, Philip R AU - Qiao, You-Lin AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland and Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Beijing, People's Republic of China Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 1889 EP - 1893 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 9 SN - 1055-9965, 1055-9965 KW - Risk Abstracts KW - Etiology KW - vitamins KW - prevention KW - Supplements KW - Lesions KW - China, People's Rep. KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20328525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Serum+25%28OH%29-Vitamin+D+Concentration+and+Risk+of+Esophageal+Squamous+Dysplasia&rft.au=Abnet%2C+Christian+C%3BChen%2C+Wen%3BDawsey%2C+Sanford+M%3BWei%2C+Wen-Qiang%3BRoth%2C+Mark+J%3BLiu%2C+Bing%3BLu%2C+Ning%3BTaylor%2C+Philip+R%3BQiao%2C+You-Lin&rft.aulast=Abnet&rft.aufirst=Christian&rft.date=2007-09-01&rft.volume=16&rft.issue=9&rft.spage=1889&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Etiology; vitamins; prevention; Lesions; Supplements; Cancer; China, People's Rep. ER - TY - JOUR T1 - Gliotoxin Is a Virulence Factor of Aspergillus fumigatus: gliP Deletion Attenuates Virulence in Mice Immunosuppressed with Hydrocortisone AN - 20317820; 7612847 AB - Gliotoxin is an immunosuppressive mycotoxin long suspected to be a potential virulence factor of Aspergillus fumigatus. Recent studies using mutants lacking gliotoxin production, however, suggested that the mycotoxin is not important for pathogenesis of A. fumigatus in neutropenic mice resulting from treatment with cyclophosphomide and hydrocortisone. In this study, we report on the pathobiological role of gliotoxin in two different mouse strains, 129/Sv and BALB/c, that were immunosuppressed by hydrocortisone alone to avoid neutropenia. These strains of mice were infected using the isogenic set of a wild type strain (B-5233) and its mutant strain (gliP Delta ) and the the glip reconstituted strain (gliP sub(R)). The gliP gene encodes a nonribosomal peptide synthase that catalyzes the first step in gliotoxin biosynthesis. The gliP Delta strain was significantly less virulent than strain B-5233 or gliP sub(R) in both mouse models. In vitro assays with culture filtrates (CFs) of B-5233, gliP Delta , and gliP sub(R) strains showed the following: (i) deletion of gliP abrogated gliotoxin production, as determined by high-performance liquid chromatography analysis; (ii) unlike the CFs from strains B-5233 and gliP sub(R), gliP Delta CFs failed to induce proapoptotic processes in EL4 thymoma cells, as tested by Bak conformational change, mitochondrial-membrane potential disruption, superoxide production, caspase 3 activation, and phosphatidylserine translocation. Furthermore, superoxide production in human neutrophils was strongly inhibited by CFs from strain B-5233 and the gliP sub(R) strain, but not the gliP Delta strain. Our study confirms that gliotoxin is an important virulence determinant of A. fumigatus and that the type of immunosuppression regimen used is important to reveal the pathogenic potential of gliotoxin. JF - Eukaryotic Cell AU - Sugui, Janyce A AU - Pardo, Julian AU - Chang, Yun C AU - Zarember, Kol A AU - Nardone, Glenn AU - Galvez, Eva M AU - Muellbacher, Arno AU - Gallin, John I AU - Simon, Markus M AU - Kwon-Chung, Kyung J AD - Laboratory of Clinical Infectious Diseases. Laboratory of Host Defense. Research Technology Branch, National Institutes of Health, Bethesda, Maryland. Max-Planck-Institute for Immunology, Freiburg, Germany. Institut fuer Physikalische Chemie, Freiburg Universitaet, Freiburg, Germany. John Curtin School of Medical Research, Australian National University, Canberra, Australia Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 1562 EP - 1569 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 6 IS - 9 SN - 1535-9778, 1535-9778 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - High-performance liquid chromatography KW - Hydrocortisone KW - Apoptosis KW - virulence factors KW - Animal models KW - Leukocytes (neutrophilic) KW - Mitochondria KW - Cell culture KW - peptide synthase KW - Neutropenia KW - Mycotoxins KW - phosphatidylserine KW - Aspergillus fumigatus KW - Superoxide KW - Caspase-3 KW - BAK protein KW - gliotoxin KW - thymoma KW - Translocation KW - Immunosuppression KW - K 03410:Animal Diseases KW - F 06910:Microorganisms & Parasites KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20317820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eukaryotic+Cell&rft.atitle=Gliotoxin+Is+a+Virulence+Factor+of+Aspergillus+fumigatus%3A+gliP+Deletion+Attenuates+Virulence+in+Mice+Immunosuppressed+with+Hydrocortisone&rft.au=Sugui%2C+Janyce+A%3BPardo%2C+Julian%3BChang%2C+Yun+C%3BZarember%2C+Kol+A%3BNardone%2C+Glenn%3BGalvez%2C+Eva+M%3BMuellbacher%2C+Arno%3BGallin%2C+John+I%3BSimon%2C+Markus+M%3BKwon-Chung%2C+Kyung+J&rft.aulast=Sugui&rft.aufirst=Janyce&rft.date=2007-09-01&rft.volume=6&rft.issue=9&rft.spage=1562&rft.isbn=&rft.btitle=&rft.title=Eukaryotic+Cell&rft.issn=15359778&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Apoptosis; Hydrocortisone; virulence factors; Leukocytes (neutrophilic); Animal models; Mitochondria; Cell culture; peptide synthase; Neutropenia; Mycotoxins; phosphatidylserine; Superoxide; Caspase-3; gliotoxin; BAK protein; Translocation; thymoma; Immunosuppression; Aspergillus fumigatus ER - TY - JOUR T1 - Design Characteristics of Worksite Environmental Interventions for Obesity Prevention AN - 20313911; 7616354 AB - OBJECTIVE: This paper describes the design characteristics of the National Heart, Lung, and Blood Institute (NHLBI)-funded studies that are testing innovative environmental interventions for weight control and obesity prevention at worksites. RESEARCH METHODS AND PROCEDURES: Seven separate studies that have a total of 114 worksites ( similar to 48,000 employees) across studies are being conducted. The worksite settings include hotels, hospitals, manufacturing facilities, businesses, schools, and bus garages located across the U.S. Each study uses its own conceptual model drawn from the literature and includes the socio-ecological model for health promotion, the epidemiological triad, and those integrating organizational and social contexts. The interventions, which are offered to all employees, include environmental- and individual-level approaches to improve physical activity and promote healthful eating practices. Environmental strategies include reducing portion sizes, modifying cafeteria recipes to lower their fat contents, and increasing the accessibility of fitness equipment at the workplace. Across all seven studies about 48% (N = 23,000) of the population is randomly selected for measurements. The primary outcome measure is change in BMI or body weight after two years of intervention. Secondary measures include waist circumference, objective, and self-report measures of physical activity, dietary intake, changes in vending machines and cafeteria food offerings, work productivity, healthcare use, and return on investment. DISCUSSION: The results of these studies could have important implications for the design and implementation of worksite overweight and obesity control programs. JF - Obesity Research AU - Pratt, Charlotte A AU - Lemon, Stephenie C AU - Fernandez, Isabel Diana AU - Goetzel, Ron AU - Beresford, Shirley A AU - French, Simone A AU - Stevens, Victor J AU - Vogt, Thomas M AU - Webber, Larry S AD - National Heart, Lung, and Blood Institute, Division of Epidemiology and Clinical Applications, Bethesda, Maryland. University of Massachusetts Medical School, Division of Preventive and Behavioral Medicine, Worcester, Massachusetts. Department of Community and Preventive Medicine, University of Rochester School of Medicine, Rochester, New York. Institute for Health and Productivity Studies, Cornell University, Washington, District of Columbia. Fred Hutchinson Cancer Research Center, Seattle, Washington, and University of Washington, Cancer Prevention Program, Seattle, Washington. University of Minnesota, School of Public Health, Minneapolis, Minnesota. Kaiser Permanente Center for Health Research, Portland, Oregon. Kaiser Foundation Hospitals, Center for Health Research, Honolulu, Hawaii. Tulane University School of Public Health, New Orleans, Louisiana Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 2171 EP - 2180 PB - North American Association for the Study of Obesity, 1090 Amsterdam Ave., Ste. 14K New York NY 10025 USA, [mailto:helener@mindspring.com], [URL:http://www.naaso.org] VL - 15 IS - 9 SN - 1071-7323, 1071-7323 KW - Physical Education Index KW - Fitness KW - Measurement KW - Programs KW - Research (statistical design) KW - Eating disorders KW - Promotion KW - Work KW - Worksite KW - Accessibility KW - Heart KW - Obesity KW - Weight control KW - Equipment KW - Business KW - Preventive health KW - Facilities KW - Strategy KW - Employees KW - Diet (weight control) KW - Exercise KW - Blood KW - Schools KW - Waist KW - Hotels KW - Lungs KW - Hospitals KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20313911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obesity+Research&rft.atitle=Design+Characteristics+of+Worksite+Environmental+Interventions+for+Obesity+Prevention&rft.au=Pratt%2C+Charlotte+A%3BLemon%2C+Stephenie+C%3BFernandez%2C+Isabel+Diana%3BGoetzel%2C+Ron%3BBeresford%2C+Shirley+A%3BFrench%2C+Simone+A%3BStevens%2C+Victor+J%3BVogt%2C+Thomas+M%3BWebber%2C+Larry+S&rft.aulast=Pratt&rft.aufirst=Charlotte&rft.date=2007-09-01&rft.volume=15&rft.issue=9&rft.spage=2171&rft.isbn=&rft.btitle=&rft.title=Obesity+Research&rft.issn=10717323&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Fitness; Measurement; Programs; Research (statistical design); Eating disorders; Promotion; Work; Worksite; Accessibility; Heart; Obesity; Equipment; Weight control; Business; Preventive health; Facilities; Strategy; Diet (weight control); Employees; Exercise; Blood; Schools; Waist; Hotels; Lungs; Hospitals ER - TY - JOUR T1 - Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tract AN - 20312447; 7637156 AB - The developing fetus is uniquely sensitive to perturbation by chemicals with hormone-like activity. The adverse effects of prenatal diethylstilbestrol (DES) exposure are a classic example. Since concern has been mounting regarding the human health and environmental effects of bisphenol A (BPA), a high-production-volume chemical with estrogenic activity used in the synthesis of plastics, we investigated its long-term effects in an experimental animal model that was previously shown useful in studying the adverse effects of developmental exposure to DES. Outbred female CD-1 mice were treated on days 1-5 with subcutaneous injections of BPA (10, 100 or 1000 mu g/kg/day) dissolved in corn oil or corn oil alone (Control). At 18 months, ovaries and reproductive tract tissues were examined. There was a statistically significant increase in cystic ovaries and cystic endometrial hyperplasia (CEH) in the BPA-100 group as compared to Controls. Progressive proliferative lesion (PPL) of the oviduct and cystic mesonephric (Wolffian) duct remnants were also seen in all of the BPA groups. More severe pathologies of the uterus following neonatal BPA treatment included adenomyosis, leiomyomas, atypical hyperplasia, and stromal polyps. These data suggest that BPA causes long-term adverse effects if exposure occurs during critical periods of differentiation. JF - Reproductive Toxicology AU - Newbold, R R AU - Jefferson, W N AU - Padilla-Banks, E AD - Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States, newbold1@niehs.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 253 EP - 258 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 24 IS - 2 SN - 0890-6238, 0890-6238 KW - Toxicology Abstracts KW - Uterus KW - Endometrium KW - Prenatal experience KW - Statistical analysis KW - Animal models KW - Polyps KW - estrogenic activity KW - Fetuses KW - Oil KW - Bisphenol A KW - Long-term effects KW - Differentiation KW - Hyperplasia KW - Oviduct KW - Environmental effects KW - Neonates KW - Ovaries KW - Plastics KW - Critical period KW - Diethylstilbestrol KW - Side effects KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20312447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+Toxicology&rft.atitle=Long-term+adverse+effects+of+neonatal+exposure+to+bisphenol+A+on+the+murine+female+reproductive+tract&rft.au=Newbold%2C+R+R%3BJefferson%2C+W+N%3BPadilla-Banks%2C+E&rft.aulast=Newbold&rft.aufirst=R&rft.date=2007-09-01&rft.volume=24&rft.issue=2&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Reproductive+Toxicology&rft.issn=08906238&rft_id=info:doi/10.1016%2Fj.reprotox.2007.07.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Endometrium; Uterus; Prenatal experience; Animal models; Statistical analysis; Polyps; estrogenic activity; Fetuses; Long-term effects; Bisphenol A; Oil; Differentiation; Hyperplasia; Oviduct; Environmental effects; Plastics; Ovaries; Neonates; Diethylstilbestrol; Critical period; Side effects DO - http://dx.doi.org/10.1016/j.reprotox.2007.07.006 ER - TY - JOUR T1 - Maternal Serum Polychlorinated Biphenyl Concentrations across Critical Windows of Human Development AN - 20306226; 7594289 AB - BACKGROUND: Few data are available on polychlorinated biphenyl (PCB) concentrations over critical windows of human reproduction and development inclusive of the periconception window. OBJECTIVES: Our goal was to measure changes in PCB concentrations from preconception to pregnancy, through pregnancy, or after a year without becoming pregnant. METHODS: Seventy-nine women planning pregnancies were prospectively enrolled and followed for up to 12 menstrual cycles of attempting pregnancy. Blood specimens were obtained from participating women preconceptionally (n = 79), after a positive pregnancy test leading to a live birth (n = 54) or pregnancy loss (n = 10), at approximately 6 weeks postpartum (n = 53), and after 12 unsuccessful cycles (n = 9) for toxicologic analysis of 76 PCB congeners. We estimated overall and daily rate of change in PCB concentration (nanograms per gram serum) adjusting for relevant covariates, serum lipids, and baseline PCB concentration. RESULTS: Significant (p < 0.0001) decreases in the mean overall and daily rate of change in PCB concentrations were observed between the preconception and first pregnancy samples for total (-1.012 and -0.034, respectively), estrogenic (-0.444 and -0.016, respectively), and antiestrogenic (-0.106 and -0.004, respectively) PCBs among women with live births. Similar significant decreases in total (-1.452 and -0.085), estrogenic (-0.647 and -0.040), and antiestrogenic (-0.093 and -0.004) PCB concentrations were seen for women with pregnancy losses. No significant changes were observed for PCB congener 153. CONCLUSIONS: These data suggest that PCB concentrations may change during the periconception interval, questioning the stability of persistent compounds during this critical window. JF - Environmental Health Perspectives AU - Bloom AU - Louis, GMB AU - Schisterman, E F AU - Liu, A AU - Kostyniak, P J AD - 6100 Executive Blvd., Rm. 7B03, Rockville, MD 20852 USA, louisg@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 1320 EP - 1324 VL - 115 IS - 9 SN - 0091-6765, 0091-6765 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Lipids KW - Environmental health KW - Reproduction KW - PCB compounds KW - Pregnancy KW - estrogens KW - H 12000:Epidemiology and Public Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20306226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Maternal+Serum+Polychlorinated+Biphenyl+Concentrations+across+Critical+Windows+of+Human+Development&rft.au=Bloom%3BLouis%2C+GMB%3BSchisterman%2C+E+F%3BLiu%2C+A%3BKostyniak%2C+P+J&rft.aulast=Bloom&rft.aufirst=&rft.date=2007-09-01&rft.volume=115&rft.issue=9&rft.spage=1320&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.10086 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Lipids; Environmental health; Reproduction; PCB compounds; estrogens; Pregnancy DO - http://dx.doi.org/10.1289/ehp.10086 ER - TY - JOUR T1 - Meat intake, preparation methods, mutagens and colorectal adenoma recurrence AN - 20304233; 7610235 AB - Red meat intake has been shown to be associated with higher risk of colorectal cancer. Though the exact mechanisms responsible for this association remain unknown, several tumorigenic properties of meat have been proposed. One well-supported biologic mechanism is elevated exposure to the genotoxic formation of heterocyclic amines (HCAs), which occur when meat is cooked at high temperatures for a long period of time. We prospectively assessed the relation between type of meat, meat preparation method, doneness, a metric of HCAs and other mutagens and colorectal adenoma recurrence among 869 participants in a chemoprevention trial of ursodeoxycholic acid. Unconditional logistic regression analyses were used to estimate odds ratios (ORs) and associated 95% confidence intervals (CIs). Most meat variables assessed were positively but weakly associated with recurrence of any adenoma. In contrast, recurrence of advanced or multiple adenomas was more strongly associated with a number of the meat exposure variables evaluated. For recurrence of advanced lesions, significant associations were detected among individuals in the highest when compared with the lowest tertile of intake for pan-fried red meat (OR = 1.85; 95% CI = 1.10-3.13) and well/very well done red meat (OR = 1.71; 95% CI = 1.02-2.86). Significant positive associations were shown for recurrence of multiple adenomas and the following variables: processed meat (OR = 1.83; 95% CI = 1.10-3.04), pan-fried red meat (OR = 1.63; 95% CI = 1.01-2.61), well/very well done red meat (OR = 1.68; 95% CI = 1.03-2.74), 2-amino-3,4,8-trimethylimidazo[4,5,-f]quinoxaline (OR = 1.74; 95% CI = 1.07-2.82) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (OR = 1.68; 95% CI = 1.03-2.75). Our results support a meat mutagen exposure hypothesis as a potential mechanism for recurrence of clinically significant adenomatous polyps. JF - Carcinogenesis AU - Martinez, Maria Elena AU - Jacobs, Elizabeth T AU - Ashbeck, Erin L AU - Sinha, Rashmi AU - Lance, Peter AU - Alberts, David S AU - Thompson, Patricia A AD - Arizona Cancer Center. Mel and Enid Zuckerman Arizona College of Public Health. Department of Nutritional Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, AZ, USA. Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA. Department of Medicine. Department of Pathology, University of Arizona, Tucson, AZ 85724, USA Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 2019 EP - 2027 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 28 IS - 9 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts KW - Temperature effects KW - Mutagens KW - Heterocyclic amines KW - Genotoxicity KW - Colorectal cancer KW - Polyps KW - Meat KW - Risk factors KW - Carcinogenesis KW - Regression analysis KW - ursodeoxycholic acid KW - Adenoma KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20304233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Meat+intake%2C+preparation+methods%2C+mutagens+and+colorectal+adenoma+recurrence&rft.au=Martinez%2C+Maria+Elena%3BJacobs%2C+Elizabeth+T%3BAshbeck%2C+Erin+L%3BSinha%2C+Rashmi%3BLance%2C+Peter%3BAlberts%2C+David+S%3BThompson%2C+Patricia+A&rft.aulast=Martinez&rft.aufirst=Maria&rft.date=2007-09-01&rft.volume=28&rft.issue=9&rft.spage=2019&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Temperature effects; Meat; Heterocyclic amines; Mutagens; Risk factors; Genotoxicity; Carcinogenesis; Regression analysis; Colorectal cancer; Polyps; ursodeoxycholic acid; Adenoma ER - TY - JOUR T1 - Coxiella burnetii Inhibits Apoptosis in Human THP-1 Cells and Monkey Primary Alveolar Macrophages AN - 20299310; 7557075 AB - Coxiella burnetii, the cause of human Q fever, is an aerosol-borne, obligate intracellular bacterium that targets host alveolar mononuclear phagocytic cells during infection. In all cell types examined, C. burnetii establishes a replicative niche in a lysosome-like parasitophorous vacuole where it carries out a lengthy infectious cycle with minimal cytopathic effects. The persistent and mild nature of C. burnetii infection in vitro suggests that the pathogen modulates apoptosis to sustain the host cell. In the current study, we examined the ability of C. burnetii to inhibit apoptotic cell death during infection of human THP-1 monocyte-derived macrophages and primary monkey alveolar macrophages. C. burnetii-infected cells demonstrated significant protection from death relative to uninfected cells following treatment with staurosporine, a potent inducer of intrinsic apoptosis. This protection correlated with reduced cleavage of caspase-9, caspase-3, and poly(ADP-ribose) polymerase (PARP), all proteolytic events that occur during apoptosis. Reduced PARP cleavage was also observed in cells treated with tumor necrosis factor alpha to induce extrinsic apoptosis. Apoptosis inhibition was a C. burnetii-driven process as infected cells treated with rifampin or chloramphenicol, inhibitors of bacterial RNA and protein synthesis, respectively, showed significantly reduced protection against staurosporine-induced apoptosis. C. burnetii infection affected the expression of multiple apoptosis-related genes and resulted in increased synthesis of the antiapoptotic proteins A1/Bfl-1 and c-IAP2. Collectively, these data suggest that C. burnetii modulates apoptotic pathways to inhibit host cell death, thus providing a stable, intracellular niche for the course of the pathogen's infectious cycle. JF - Infection and Immunity AU - Voth, Daniel E AU - Howe, Dale AU - Heinzen, Robert A AD - Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840 Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 4263 EP - 4271 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 9 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Proteolysis KW - Macrophages KW - Caspase-9 KW - Chloramphenicol KW - Protein biosynthesis KW - Apoptosis KW - Transcription KW - Pathogens KW - Infection KW - Alveoli KW - double prime Q fever KW - parasitophorous vacuole KW - Coxiella burnetii KW - Rifampin KW - RNA KW - Poly(ADP-ribose) polymerase KW - Staurosporine KW - Caspase-3 KW - Tumor necrosis factor- alpha KW - Monocytes KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20299310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Coxiella+burnetii+Inhibits+Apoptosis+in+Human+THP-1+Cells+and+Monkey+Primary+Alveolar+Macrophages&rft.au=Voth%2C+Daniel+E%3BHowe%2C+Dale%3BHeinzen%2C+Robert+A&rft.aulast=Voth&rft.aufirst=Daniel&rft.date=2007-09-01&rft.volume=75&rft.issue=9&rft.spage=4263&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Macrophages; Proteolysis; Caspase-9; Chloramphenicol; Apoptosis; Protein biosynthesis; Transcription; Pathogens; Infection; double prime Q fever; Alveoli; parasitophorous vacuole; Rifampin; RNA; Poly(ADP-ribose) polymerase; Staurosporine; Caspase-3; Monocytes; Tumor necrosis factor- alpha; Coxiella burnetii ER - TY - JOUR T1 - Dectin-1 Interaction with Mycobacterium tuberculosis Leads to Enhanced IL-12p40 Production by Splenic Dendritic Cells AN - 20244222; 7614843 AB - Dectin-1 is a fungal pattern recognition receptor that binds to beta -glucans and triggers cytokine production by facilitating interaction with TLR2 or by directly activating spleen tyrosine kinase (Syk). To assess the possible role of Dectin-1 in the innate response to mycobacteria, we used an in vitro system in which IL-12p40 production is measured in splenic dendritic cells (SpDC) following exposure to live Mycobacterium tuberculosis bacilli. Treatment of SpDC with laminarin or glucan phosphate, two molecules known to block Dectin-1-dependent activity, led to a reduction in M. tuberculosis-induced IL-12p40 as well as IL-12p70 production. Moreover, SpDC from Dectin-1 super(-/-) chimeric mice displayed reduced IL-12p40 production in response to mycobacteria when compared with Dectin-sufficient DC. Laminarin treatment also inhibited mycobacterial-induced IL-12p40 production in DC from TLR2 super(-/-) mice, arguing that Dectin-1 functions independently of TLR2 signaling in this system. Importantly, a Dectin-1 fusion protein was found to directly bind to live mycobacteria in a laminarin-inhibitable manner indicating the presence of ligands for the receptor in the bacterium and laminarin pretreatment resulted in reduced association of mycobacteria to SpDC. In additional experiments, mycobacterial stimulation was shown to be associated with increased phosphorylation of Syk and this response was inhibited by laminarin. Furthermore, pharmacologic inhibition of Syk reduced the M. tuberculosis-induced IL-12p40 response. Together, these findings support a role for Dectin-1 in promoting M. tuberculosis-induced IL-12p40 production by DC in which the receptor augments bacterial-host cell interaction and enhances the subsequent cytokine response through an unknown mechanism involving Syk signaling. JF - Journal of Immunology AU - Rothfuchs, Antonio Gigliotti AU - Bafica, Andre AU - Feng, Carl G AU - Egen, Jackson G AU - Williams, David L AU - Brown, Gordon D AU - Sher, Alan AD - Immunobiology Section, Laboratory of Parasitic Diseases and Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892. Division of Immunology, Department of Microbiology and Parasitology, Federal University of Santa Catarina, Florianopolis, Brazil. Department of Surgery, James H. Quillen College of Medicine, Johnson City, TN 37614. Division of Immunology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch, South Africa Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 3463 EP - 3471 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 179 IS - 6 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Bacilli KW - TLR2 protein KW - Spleen KW - Syk protein KW - beta -Glucan KW - Pattern recognition KW - Dendritic cells KW - Interleukin 12 KW - Phosphorylation KW - Phosphate KW - Protein-tyrosine kinase KW - Fusion protein KW - Cell interactions KW - Toll-like receptors KW - laminarin KW - glucans KW - Mycobacterium tuberculosis KW - Signal transduction KW - K 03350:Immunology KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20244222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Dectin-1+Interaction+with+Mycobacterium+tuberculosis+Leads+to+Enhanced+IL-12p40+Production+by+Splenic+Dendritic+Cells&rft.au=Rothfuchs%2C+Antonio+Gigliotti%3BBafica%2C+Andre%3BFeng%2C+Carl+G%3BEgen%2C+Jackson+G%3BWilliams%2C+David+L%3BBrown%2C+Gordon+D%3BSher%2C+Alan&rft.aulast=Rothfuchs&rft.aufirst=Antonio&rft.date=2007-09-01&rft.volume=179&rft.issue=6&rft.spage=3463&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Bacilli; TLR2 protein; Spleen; Syk protein; beta -Glucan; Interleukin 12; Dendritic cells; Pattern recognition; Phosphate; Phosphorylation; Protein-tyrosine kinase; Cell interactions; Fusion protein; glucans; laminarin; Toll-like receptors; Signal transduction; Mycobacterium tuberculosis ER - TY - JOUR T1 - Neurotoxicity of substituted amphetamines: Molecular and cellular mechanisms AN - 20151458; 10263304 AB - The amphetamines, including amphetamine (AMPH), methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA), are among abused drugs in the US and throughout the world. Their abuse is associated with severe neurologic and psychiatric adverse events including the development of psychotic states. These neuropsychiatric complications might, in part, be related to drug-induced neurotoxic effects, which include damage to dopaminergic and serotonergic terminals, neuronal apoptosis, as well as activated astroglial and microglial cells in the brain. The purpose of the present review is to summarize the toxic effects of AMPH, METH and MDMA. The paper also presents some of the factors that are thought to underlie this toxicity. These include oxidative stress, hyperthermia, excitotoxicity and various apoptotic pathways. Better understanding of the cellular and molecular mechanisms involved in their toxicity should help to generate modern therapeutic approaches to prevent or attenuate the long-term consequences of amphetamine use disorders in humans. JF - Neurotoxicity Research AU - Cadet, Jean Lud AU - Krasnova, Irina N AU - Jayanthi, Subramaniam AU - Lyles, Johnalyn AD - Molecular Neuropsychiatry Branch, DHHS/NIH/NIDA, Intramural Research Program, 5500 Nathan Shock Drive, 21224 Baltimore, Maryland, USA, jcadet@intra.nida.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 183 EP - 202 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 11 IS - 3-4 SN - 1029-8428, 1029-8428 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Molecular modelling KW - Hyperthermia KW - Apoptosis KW - Brain KW - Drug abuse KW - MDMA KW - Serotonin KW - Methamphetamine KW - Dopamine KW - Oxidative stress KW - Reviews KW - Neurotoxicity KW - Amphetamine KW - Microglial cells KW - Excitotoxicity KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20151458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicity+Research&rft.atitle=Neurotoxicity+of+substituted+amphetamines%3A+Molecular+and+cellular+mechanisms&rft.au=Cadet%2C+Jean+Lud%3BKrasnova%2C+Irina+N%3BJayanthi%2C+Subramaniam%3BLyles%2C+Johnalyn&rft.aulast=Cadet&rft.aufirst=Jean&rft.date=2007-09-01&rft.volume=11&rft.issue=3-4&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Neurotoxicity+Research&rft.issn=10298428&rft_id=info:doi/10.1007%2FBF03033567 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Hyperthermia; Apoptosis; Brain; Drug abuse; MDMA; Serotonin; Methamphetamine; Dopamine; Oxidative stress; Reviews; Neurotoxicity; Amphetamine; Microglial cells; Excitotoxicity DO - http://dx.doi.org/10.1007/BF03033567 ER - TY - JOUR T1 - Performance characteristics of 65-mer oligonucleotide microarrays AN - 20091423; 7537068 AB - Microarray fabrication using presynthesized long oligonucleotide is becoming increasingly important, but a study of large-scale array productions has not yet been published. We addressed the issue of fabricating oligonucleotide microarrays by spotting commercial presynthesized 65-mers with 5' amines representing 7500 murine genes. Amine-modified oligonucleotides were immobilized on glass slides having aldehyde groups via transient Schiff base formation followed by reduction to produce a covalent conjugate. When RNA derived from the same source was used for Cy3 and Cy5 labeling and hybridized to the same array, signal intensities spanning three orders of magnitude were observed and the coefficient of variance (CV) between the two channels for all spots was 8 to 10%. To ascertain the reproducibility of ratio determination of these arrays, two triplicate hybridizations (with fluorochrome reversal) comparing RNAs from a fibroblast (NIH3T3) and a breast cancer (JC) cell line were carried out. The 95% confidence interval for all spots in the six hybridizations was 0.60 to 1.66. This level of reproducibility allows use of the full range of pattern finding and discriminant analysis typically applied to complementary DNA (cDNA) microarrays. Further comparative testing was carried out with oligonucleotide microarrays, cDNA microarrays, and reverse transcription (RT)-PCR assays to examine the comparability of results across these different methodologies. JF - Analytical Biochemistry AU - Lee, Myoyong AU - Xiang, Charlie C AU - Trent, Jeffrey M AU - Bittner, Michael L AD - Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA, myoyong.lee@samsung.com Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 70 EP - 78 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 368 IS - 1 SN - 0003-2697, 0003-2697 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Oligonucleotide KW - Microarray KW - Gene expression KW - Tumor cell lines KW - amines KW - RNA KW - Breast cancer KW - fluorochromes KW - Aldehydes KW - DNA microarrays KW - Oligonucleotides KW - Fibroblasts KW - Reverse transcription KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20091423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Biochemistry&rft.atitle=Performance+characteristics+of+65-mer+oligonucleotide+microarrays&rft.au=Lee%2C+Myoyong%3BXiang%2C+Charlie+C%3BTrent%2C+Jeffrey+M%3BBittner%2C+Michael+L&rft.aulast=Lee&rft.aufirst=Myoyong&rft.date=2007-09-01&rft.volume=368&rft.issue=1&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=Analytical+Biochemistry&rft.issn=00032697&rft_id=info:doi/10.1016%2Fj.ab.2007.05.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - amines; Tumor cell lines; RNA; Breast cancer; fluorochromes; Aldehydes; Oligonucleotides; DNA microarrays; Reverse transcription; Fibroblasts DO - http://dx.doi.org/10.1016/j.ab.2007.05.010 ER - TY - JOUR T1 - Optimization of oligonucleotide microarray fabricated by spotting 65-mer AN - 20091254; 7537067 AB - DNA microarrays currently provide measurements of sufficiently high quality to allow a wide variety of sound inferences about gene regulation and the coordination of cellular processes to be drawn. Nonetheless, a desire for greater precision in the measurements continues to drive the microarray research community to seek higher measurement quality through improvements in array fabrication and sample labeling and hybridization. We prepared oligonucleotide microarrays by printing 65-mer on aldehyde functional group-derivatized slides as described in a previous study. We could improve the reliability of data by removing enzymatic bias during probe labeling and hybridizing under a more stringent condition. This optimized method was used to profile gene expression patterns for nine different mouse tissues and organs, and multidimensional scaling (MDS) analysis of data showed both strong similarity between like samples and a clear, highly reproducible separation between different tissue samples. Three other microarrays were fabricated on commercial substrates and hybridized following the manufacturer's instructions. The data were then compared with in-house microarray data and reverse transcription-polymerase chain reaction (RT-PCR) data. The microarray printed on the custom aldehyde slide was superior to microarrays printed on commercially available substrate slides in terms of signal intensities, background, and hybridization characteristics. The data from the custom substrate microarray generally showed good agreement in quantitative changes up to 100-fold changes of transcript abundance with RT-PCR data. However, more accurate comparisons will be made as more genomic sequence information is gathered in the public data domain. JF - Analytical Biochemistry AU - Lee, Myoyong AU - Trent, Jeffrey M AU - Bittner, Michael L AD - Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA, myoyong.lee@samsung.com Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 61 EP - 69 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 368 IS - 1 SN - 0003-2697, 0003-2697 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Oligonucleotide KW - Microarray KW - Spotting KW - Gene expression KW - Printing KW - Data processing KW - DNA probes KW - Abundance KW - Transcription KW - Oligonucleotides KW - DNA microarrays KW - Gene regulation KW - Multidimensional scaling KW - Sound KW - Polymerase chain reaction KW - genomics KW - Aldehydes KW - W 30910:Imaging KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20091254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+biological+therapy&rft.atitle=First-generation+blood+substitutes%3A+what+have+we+learned%3F+Biochemical+and+physiological+perspectives.&rft.au=Alayash%2C+Abdu+I%3BD%27Agnillo%2C+Felice%3BBuehler%2C+Paul+W&rft.aulast=Alayash&rft.aufirst=Abdu&rft.date=2007-05-01&rft.volume=7&rft.issue=5&rft.spage=665&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+biological+therapy&rft.issn=1744-7682&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Data processing; Printing; DNA probes; Abundance; Transcription; DNA microarrays; Oligonucleotides; Gene expression; Gene regulation; Multidimensional scaling; Sound; Polymerase chain reaction; genomics; Aldehydes DO - http://dx.doi.org/10.1016/j.ab.2007.06.005 ER - TY - JOUR T1 - AffyProbeMiner: a web resource for computing or retrieving accurately redefined Affymetrix probe sets AN - 20025689; 7609368 AB - MOTIVATION: Affymetrix microarrays are widely used to measure global expression of mRNA transcripts. That technology is based on the concept of a probe set. Individual probes within a probe set were originally designated by Affymetrix to hybridize with the same unique mRNA transcript. Because of increasing accuracy in knowledge of genomic sequences, however, a substantial number of the manufacturer's original probe groupings and mappings are now known to be inaccurate and must be corrected. Otherwise, analysis and interpretation of an Affymetrix microarray experiment will be in error. RESULTS: AffyProbeMiner is a computationally efficient platform-independent tool that uses all RefSeq mature RNA protein coding transcripts and validated complete coding sequences in GenBank to (1) regroup the individual probes into consistent probe sets and (2) remap the probe sets to the correct sets of mRNA transcripts. The individual probes are grouped into probe sets that are 'transcript-consistent' in that they hybridize to the same mRNA transcript (or transcripts) and, therefore, measure the same entity (or entities). About 65.6 % of the probe sets on the HG-U133A chip were affected by the remapping. Pre-computed regrouped and remapped probe sets for many Affymetrix microarrays are made freely available at the AffyProbeMiner web site. Alternatively, we provide a web service that enables the user to perform the remapping for any type of short-oligo commercial or custom array that has an Affymetrix-format Chip Definition File (CDF). Important features that differentiate AffyProbeMiner from other approaches are flexibility in the handling of splice variants, computational efficiency, extensibility, customizability and user-friendliness of the interface. AVAILABILITY: The web interface and software (GPL open source license), are publicly-accessible at http://discover.nci.nih.gov/affyprobeminer. CONTACT: hl224atgeorgetown.edu or barryatdiscover.nci.nih.gov JF - Bioinformatics AU - Liu, Hongfang AU - Zeeberg, Barry R AU - Qu, Gang AU - Koru, AGunes AU - Ferrucci, Alessandro AU - Kahn, Ari AU - Ryan, Michael C AU - Nuhanovic, Antej AU - Munson, Peter J AU - Reinhold, William C AU - Kane, David W AU - Weinstein, John N AD - Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, Department of Biostatistics, Bioinformatics, and Biomathematics, Georgetown University Medical Center, 4000 Reservoir Road, NW, Washington, DC 20007, Electrical & Computer Engineering and Institute for Advanced Studies, University of Maryland, College Park, College Park, MD 20742, Department of Information Systems, Department of Computer Science and Electrical Engineering, University of Maryland, Baltimore County, 1000 Hilltop Circle, MD 21050, Department of Bioinformatics, George Mason University, Fairfax, Virginia, 20110, Mathematical and Statistical Computing Laboratory, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892 and SRA International, 4300 Fair Lakes Court, Fairfax, VA 22033, USA Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 2385 EP - 2390 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 23 IS - 18 SN - 1367-4803, 1367-4803 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Computer programs KW - software KW - DNA probes KW - Bioinformatics KW - genomics KW - Computer applications KW - Internet KW - Alternative splicing KW - Gene mapping KW - N 14815:Nucleotide Sequence KW - W 30960:Bioinformatics & Computer Applications KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20025689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=AffyProbeMiner%3A+a+web+resource+for+computing+or+retrieving+accurately+redefined+Affymetrix+probe+sets&rft.au=Liu%2C+Hongfang%3BZeeberg%2C+Barry+R%3BQu%2C+Gang%3BKoru%2C+AGunes%3BFerrucci%2C+Alessandro%3BKahn%2C+Ari%3BRyan%2C+Michael+C%3BNuhanovic%2C+Antej%3BMunson%2C+Peter+J%3BReinhold%2C+William+C%3BKane%2C+David+W%3BWeinstein%2C+John+N&rft.aulast=Liu&rft.aufirst=Hongfang&rft.date=2007-09-01&rft.volume=23&rft.issue=18&rft.spage=2385&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gene expression; Computer programs; software; DNA probes; genomics; Bioinformatics; Computer applications; Internet; Gene mapping; Alternative splicing ER - TY - JOUR T1 - RSV604, a Novel Inhibitor of Respiratory Syncytial Virus Replication AN - 20004075; 7554009 AB - Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infections worldwide, yet no effective vaccine or antiviral treatment is available. Here we report the discovery and initial development of RSV604, a novel benzodiazepine with submicromolar anti-RSV activity. It proved to be equipotent against all clinical isolates tested of both the A and B subtypes of the virus. The compound has a low rate of in vitro resistance development. Sequencing revealed that the resistant virus had mutations within the nucleocapsid protein. This is a novel mechanism of action for anti-RSV compounds. In a three-dimensional human airway epithelial cell model, RSV604 was able to pass from the basolateral side of the epithelium effectively to inhibit virus replication after mucosal inoculation. RSV604, which is currently in phase II clinical trials, represents the first in a new class of RSV inhibitors and may have significant potential for the effective treatment of RSV disease. JF - Antimicrobial Agents & Chemotherapy AU - Chapman, Joanna AU - Abbott, Elizabeth AU - Alber, Dagmar G AU - Baxter, Robert C AU - Bithell, Sian K AU - Henderson, Elisa A AU - Carter, Malcolm C AU - Chambers, Phil AU - Chubb, Ann AU - Cockerill, GStuart AU - Collins, Peter L AU - Dowdell, Verity CL AU - Keegan, Sally J AU - Kelsey, Richard D AU - Lockyer, Michael J AU - Luongo, Cindy AU - Najarro, Pilar AU - Pickles, Raymond J AU - Simmonds, Mark AU - Taylor, Debbie AU - Tyms, Stan AU - Wilson, Lara J AU - Powell, Kenneth L AD - Arrow Therapeutics Ltd., Britannia House, 7 Trinity Street, London SE1 1DB, United Kingdom. Virogen Ltd., MRC Technology, 1-3 Burtonhole Lane, Mill Hill, London NW7 1AD, United Kingdom. Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, 7 Center Drive, MSC 0720, Bethesda, Maryland. Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 3346 EP - 3353 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 51 IS - 9 SN - 0066-4804, 0066-4804 KW - RSV604 KW - anti-RSV activity KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Clinical isolates KW - Epithelial cells KW - Replication KW - Mucosa KW - Cell culture KW - Infection KW - Clinical trials KW - Respiratory syncytial virus KW - Respiratory tract diseases KW - Benzodiazepine KW - Nucleocapsids KW - Inoculation KW - Epithelium KW - Vaccines KW - Mutation KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents KW - V 22320:Replication KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20004075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=RSV604%2C+a+Novel+Inhibitor+of+Respiratory+Syncytial+Virus+Replication&rft.au=Chapman%2C+Joanna%3BAbbott%2C+Elizabeth%3BAlber%2C+Dagmar+G%3BBaxter%2C+Robert+C%3BBithell%2C+Sian+K%3BHenderson%2C+Elisa+A%3BCarter%2C+Malcolm+C%3BChambers%2C+Phil%3BChubb%2C+Ann%3BCockerill%2C+GStuart%3BCollins%2C+Peter+L%3BDowdell%2C+Verity+CL%3BKeegan%2C+Sally+J%3BKelsey%2C+Richard+D%3BLockyer%2C+Michael+J%3BLuongo%2C+Cindy%3BNajarro%2C+Pilar%3BPickles%2C+Raymond+J%3BSimmonds%2C+Mark%3BTaylor%2C+Debbie%3BTyms%2C+Stan%3BWilson%2C+Lara+J%3BPowell%2C+Kenneth+L&rft.aulast=Chapman&rft.aufirst=Joanna&rft.date=2007-09-01&rft.volume=51&rft.issue=9&rft.spage=3346&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Epithelial cells; Replication; Mucosa; Cell culture; Infection; Clinical trials; Respiratory tract diseases; Benzodiazepine; Inoculation; Nucleocapsids; Epithelium; Vaccines; Mutation; Respiratory syncytial virus ER - TY - JOUR T1 - Oxygen Tension Regulates Survival and Fate of Mouse Central Nervous System Precursors at Multiple Levels AN - 20003203; 7617395 AB - Despite evidence that oxygen regulates neural precursor fate, the effects of changing oxygen tensions on distinct stages in precursor differentiation are poorly understood. We found that 5% oxygen permitted clonal and long-term expansion of mouse fetal cortical precursors. In contrast, 20% oxygen caused a rapid decrease in hypoxia-inducible factor 1 alpha and nucleophosmin, followed by the induction of p53 and apoptosis of cells. This led to a decrease in overall cell number and particularly a loss of astrocytes and oligodendrocytes. Clonal analysis revealed that apoptosis in 20% oxygen was due to a complete loss of CD133 super(lo)CD24 super(lo) multipotent precursors, a substantial loss of CD133 super(hi)CD24 super(lo) multipotent precursors, and a failure of remaining CD133 super(hi)CD24 super(lo) cells to generate glia. In contrast, committed neuronal progenitors were not significantly affected. Switching clones from 5% to 20% oxygen only after mitogen withdrawal led to a decrease in total clone numbers but an even greater decrease in oligodendrocyte-containing clones. During this late exposure to 20% oxygen, bipotent glial (A2B5 super(+)) and early (platelet-derived growth factor receptor alpha ) oligodendrocyte progenitors appeared and disappeared more quickly, relative to 5% oxygen, and late stage O4 super(+) oligodendrocyte progenitors never appeared. These results indicate that multipotent cells and oligodendrocyte progenitors are more susceptible to apoptosis at 20% oxygen than committed neuronal progenitors. This has important implications for optimizing ex vivo production methods for cell replacement therapies. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Chen, Hui-Ling AU - Pistollato, Francesca AU - Hoeppner, Daniel J AU - Ni, Hsiao-Tzu AU - McKay, Ronald DG AU - Panchision, David M AD - Center for Neuroscience Research, Children's National Medical Center, Washington, DC, USA. Hemato-Oncology Laboratory, Department of Pediatrics, University of Padua, Padua, Italy. Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA. R&D Systems, Inc., Minneapolis, Minnesota, USA Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 2291 EP - 2301 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 25 IS - 9 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Central nervous system KW - Apoptosis KW - Cell number KW - Oxygen tension KW - Oligodendrocytes KW - Astrocytes KW - Hypoxia-inducible factor 1 alpha KW - Fetuses KW - p53 protein KW - Differentiation KW - Stem cells KW - Glial stem cells KW - Platelet-derived growth factor receptors KW - Glia KW - Mitogens KW - Neural stem cells KW - W 30965:Miscellaneous, Reviews KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20003203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Oxygen+Tension+Regulates+Survival+and+Fate+of+Mouse+Central+Nervous+System+Precursors+at+Multiple+Levels&rft.au=Chen%2C+Hui-Ling%3BPistollato%2C+Francesca%3BHoeppner%2C+Daniel+J%3BNi%2C+Hsiao-Tzu%3BMcKay%2C+Ronald+DG%3BPanchision%2C+David+M&rft.aulast=Chen&rft.aufirst=Hui-Ling&rft.date=2007-09-01&rft.volume=25&rft.issue=9&rft.spage=2291&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Central nervous system; Apoptosis; Astrocytes; Oligodendrocytes; Oxygen tension; Cell number; Hypoxia-inducible factor 1 alpha; Fetuses; p53 protein; Differentiation; Stem cells; Glial stem cells; Platelet-derived growth factor receptors; Glia; Mitogens; Neural stem cells ER - TY - JOUR T1 - Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulation AN - 20003096; 7616844 AB - The mechanisms that regulate hematopoietic stem cell (HSC) fate decisions between proliferation and multilineage differentiation are unclear. Members of the Wnt family of ligands that activate the canonical Wnt signaling pathway, which utilizes beta -catenin to relay the signal, have been demonstrated to regulate HSC function. In this study, we examined the role of noncanonical Wnt signaling in regulating HSC fate. We observed that noncanonical Wnt5a inhibited Wnt3a-mediated canonical Wnt signaling in HSCs and suppressed Wnt3a-mediated alterations in gene expression associated with HSC differentiation, such as increased expression of myc. Wnt5a increased short- and long-term HSC repopulation by maintaining HSCs in a quiescent G sub(0) state. From these data, we propose that Wnt5a regulates hematopoiesis by the antagonism of the canonical Wnt pathway, resulting in a pool of quiescent HSCs. JF - Proceedings of the National Academy of Sciences, USA AU - Nemeth, Michael J AU - Topol, Lilia AU - Anderson, Stacie M AU - Yang, Yingzi AU - Bodine, David M AD - Genetics and Molecular Biology Branch and Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, MD 20892-4442 Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 15436 EP - 15441 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 39 SN - 0027-8424, 0027-8424 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Gene expression KW - Myc protein KW - Differentiation KW - Stem cells KW - Wnt protein KW - catenin KW - Data processing KW - Hemopoiesis KW - Antagonism KW - Signal transduction KW - G 07730:Development & Cell Cycle KW - W 30970:Book & Conference Notices UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20003096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Wnt5a+inhibits+canonical+Wnt+signaling+in+hematopoietic+stem+cells+and+enhances+repopulation&rft.au=Nemeth%2C+Michael+J%3BTopol%2C+Lilia%3BAnderson%2C+Stacie+M%3BYang%2C+Yingzi%3BBodine%2C+David+M&rft.aulast=Nemeth&rft.aufirst=Michael&rft.date=2007-09-01&rft.volume=104&rft.issue=39&rft.spage=15436&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Myc protein; Gene expression; Differentiation; Stem cells; Data processing; catenin; Wnt protein; Hemopoiesis; Antagonism; Signal transduction ER - TY - JOUR T1 - Expression of Interleukin-13 Receptor alpha 2 in Glioblastoma Multiforme: Implications for Targeted Therapies AN - 19876213; 7609987 AB - Glioblastoma multiforme is the most common primary malignant brain tumor and despite treatment with surgery, radiation, and chemotherapy, the median survival of patients with glioblastoma multiforme is similar to 1 year. Glioblastoma multiforme explants and cell lines have been reported to overexpress the interleukin-13 receptor alpha 2 subunit (IL13R alpha 2) relative to nonneoplastic brain. Based on this finding, a recombinant cytotoxin composed of IL13 ligand and a truncated form of Pseudomonas aeruginosa exotoxin A (IL13-PE38QQR) was developed for the targeted treatment of glioblastoma multiforme tumors. In a recently completed phase III clinical trial, however, IL13-PE38QQR was found to be no more effective than an existing therapy in prolonging survival. To determine possible explanations for this result, we analyzed the relative expression levels of IL13R alpha 2 in glioblastoma multiforme and nonneoplastic brain specimens using publicly available oligonucleotide microarray databases, quantitative real-time reverse transcription PCR, and immunohistochemical staining. Increased expression of the IL13R alpha 2 gene relative to nonneoplastic brain was observed in 36 of 81 (44%) and 8 of 17 (47%) tumor specimens by microarray and quantitative real-time reverse transcription PCR analyses, respectively. Immunohistochemical staining of tumor specimens showed highly variable expression of IL13R alpha 2 protein both within and across specimens. These data indicate that prescreening of subjects may be of benefit in future trials of IL13R alpha 2 targeting therapies. [Cancer Res 2007; 67(17):7983-6] JF - Cancer Research AU - Jarboe, John S AU - Johnson, Kory R AU - Choi, Yong AU - Lonser, Russell R AU - Park, John K AD - Surgical and Molecular Neuro-oncology Unit, Bioinformatics Group, Intramural Information Technology Program, Division of Intramural Research, and Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - 7983 EP - 7986 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 67 IS - 17 SN - 0008-5472, 0008-5472 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Data processing KW - glioblastoma multiforme KW - Cytotoxins KW - Chemotherapy KW - Interleukin 1 KW - Survival KW - exotoxin A KW - DNA microarrays KW - Clinical trials KW - Oligonucleotides KW - Cancer KW - Reverse transcription KW - Brain tumors KW - Databases KW - Interleukin 13 KW - Radiation KW - Surgery KW - Polymerase chain reaction KW - Pseudomonas aeruginosa KW - Explants KW - F 06915:Cancer Immunology KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19876213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Genetic+alterations+in+K-ras+and+p53+cancer+genes+in+lung+neoplasms+from+Swiss+%28CD-1%29+male+mice+exposed+transplacentally+to+AZT&rft.au=Hong%2C+Hue-Hua+L%3BDunnick%2C+June%3BHerbert%2C+Ronald%3BDevereux%2C+Theodora+R%3BKim%2C+Yongbaek%3BSills%2C+Robert+C&rft.aulast=Hong&rft.aufirst=Hue-Hua&rft.date=2007-05-01&rft.volume=48&rft.issue=3-4&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20197 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Data processing; glioblastoma multiforme; Chemotherapy; Cytotoxins; Interleukin 1; Survival; Oligonucleotides; Clinical trials; DNA microarrays; exotoxin A; Cancer; Reverse transcription; Brain tumors; Databases; Interleukin 13; Radiation; Surgery; Polymerase chain reaction; Explants; Pseudomonas aeruginosa ER - TY - JOUR T1 - Expression of a CALM-AF10 Fusion Gene Leads to Hoxa Cluster Overexpression and Acute Leukemia in Transgenic Mice AN - 19875660; 7609994 AB - To assess the role of the CALM-AF10 fusion gene in leukemic transformation in vivo, we generated transgenic mice that expressed a CALM-AF10 fusion gene. Depending on the transgenic line, at least 40% to 50% of the F sub(1) generation mice developed acute leukemia at a median age of 12 months. Leukemic mice typically had enlarged spleens, invasion of parenchymal organs with malignant cells, and tumors with myeloid markers such as myeloperoxidase, Mac1, and Gr1. Although most leukemias were acute myeloid leukemia, many showed lymphoid features, such as CD3 staining, or clonal Tcrb or Igh gene rearrangements. Mice were clinically healthy for the first 9 months of life and had normal peripheral blood hemograms but showed impaired thymocyte differentiation, manifested by decreased CD4 super(+)/CD8 super(+) cells and increased immature CD4 super(-)/CD8 super(-) cells in the thymus. Hematopoietic tissues from both clinically healthy and leukemic CALM-AF10 mice showed up-regulation of Hoxa cluster genes, suggesting a potential mechanism for the impaired differentiation. The long latency period and incomplete penetrance suggest that additional genetic events are needed to complement the CALM-AF10 transgene and complete the process of leukemic transformation. [Cancer Res 2007; 67(17):8022-31] JF - Cancer Research AU - Caudell, David AU - Zhang, Zhenhua AU - Chung, Yang Jo AU - Aplan, Peter D AD - Genetics Branch and Comparative Molecular Pathology Unit, National Cancer Institute, National Institutes for Health, Bethesda, Maryland and Department of Veterinary Medical Sciences, University of Maryland, College Park, Maryland Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - 8022 EP - 8031 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 67 IS - 17 SN - 0008-5472, 0008-5472 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Transformation KW - Age KW - Acute myeloid leukemia KW - double prime T-cell receptor KW - Peroxidase KW - Thymus KW - Spleen KW - Peripheral blood KW - Tumors KW - CD8 antigen KW - Transgenic mice KW - Cancer KW - Differentiation KW - CD4 antigen KW - Gene fusion KW - gene rearrangement KW - Hemopoiesis KW - Thymocytes KW - CD3 antigen KW - Fusion protein KW - Immunoglobulins KW - W 30925:Genetic Engineering KW - F 06915:Cancer Immunology KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19875660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Expression+of+a+CALM-AF10+Fusion+Gene+Leads+to+Hoxa+Cluster+Overexpression+and+Acute+Leukemia+in+Transgenic+Mice&rft.au=Caudell%2C+David%3BZhang%2C+Zhenhua%3BChung%2C+Yang+Jo%3BAplan%2C+Peter+D&rft.aulast=Caudell&rft.aufirst=David&rft.date=2007-09-01&rft.volume=67&rft.issue=17&rft.spage=8022&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Transformation; Age; Acute myeloid leukemia; Peroxidase; double prime T-cell receptor; Thymus; Spleen; Peripheral blood; CD8 antigen; Tumors; Transgenic mice; Cancer; Differentiation; CD4 antigen; gene rearrangement; Gene fusion; Hemopoiesis; Thymocytes; Fusion protein; CD3 antigen; Immunoglobulins ER - TY - JOUR T1 - The RAGNYA fold: a novel fold with multiple topological variants found in functionally diverse nucleic acid, nucleotide and peptide-binding proteins AN - 19795544; 7616184 AB - Using sensitive structure similarity searches, we identify a shared alpha +{szligbeta} fold, RAGNYA, principally involved in nucleic acid, nucleotide or peptide interactions in a diverse group of proteins. These include the Ribosomal proteins L3 and L1, ATP-grasp modules, the GYF domain, DNA-recombination proteins of the NinB family from caudate bacteriophages, the C-terminal DNA-interacting domain of the Y-family DNA polymerases, the uncharacterized enzyme AMMECR1, the siRNA silencing repressor of tombusviruses, tRNA Wybutosine biosynthesis enzyme Tyw3p, DNA/RNA ligases and related nucleotidyltransferases and the Enhancer of rudimentary proteins. This fold exhibits three distinct circularly permuted versions and is composed of an internal repeat of a unit with two-strands and a helix. We show that despite considerable structural diversity in the fold, its representatives show a common mode of nucleic acid or nucleotide interaction via the exposed face of the sheet. Using this information and sensitive profile-based sequence searches: (1) we predict the active site, and mode of substrate interaction of the Wybutosine biosynthesis enzyme, Tyw3p, and a potential catalytic role for AMMECR1. (2) We provide insights regarding the mode of nucleic acid interaction of the NinB proteins, and the evolution of the active site of classical ATP-grasp enzymes and DNA/RNA ligases. (3) We also present evidence for a bacterial origin of the GYF domain and propose how this version of the fold might have been utilized in peptide interactions in the context of nucleoprotein complexes. JF - Nucleic Acids Research AU - Balaji, S AU - Aravind, L AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 5658 EP - 5671 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 35 IS - 17 SN - 0305-1048, 0305-1048 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Phages KW - DNA biosynthesis KW - tRNA KW - Nucleotide sequence KW - Nucleoproteins KW - Enzymes KW - Nucleotides KW - Enhancers KW - nucleic acids KW - siRNA KW - DNA-directed DNA polymerase KW - ribosomal protein L3 KW - Repressors KW - peptide-binding protein KW - RNA ligase KW - Evolution KW - J 02320:Cell Biology KW - V 22320:Replication KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19795544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=The+RAGNYA+fold%3A+a+novel+fold+with+multiple+topological+variants+found+in+functionally+diverse+nucleic+acid%2C+nucleotide+and+peptide-binding+proteins&rft.au=Balaji%2C+S%3BAravind%2C+L&rft.aulast=Balaji&rft.aufirst=S&rft.date=2007-09-01&rft.volume=35&rft.issue=17&rft.spage=5658&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Phages; DNA biosynthesis; Nucleotide sequence; tRNA; Nucleoproteins; Enzymes; Nucleotides; Enhancers; nucleic acids; siRNA; DNA-directed DNA polymerase; ribosomal protein L3; Repressors; Evolution; RNA ligase; peptide-binding protein ER - TY - JOUR T1 - Radioimmunotherapy with alpha -Particle-Emitting super(213)Bi-C-Functionalized trans-Cyclohexyl-Diethylenetriaminepentaacetic Acid-Humanized 3S193 Is Enhanced by Combination with Paclitaxel Chemotherapy AN - 19787028; 7612371 AB - PURPOSE: Previous experience in solid tumor radioimmunotherapy studies has indicated that greatest therapeutic efficacy is achieved in the treatment of small-volume disease. alpha -Particle-emitting radioisotopes possess several physical characteristics ideally suited to the treatment of minimal residual disease. Therefore, we have investigated the efficacy of the alpha -particle-emitting bismuth-213 ( super(213)Bi) radioimmunotherapy using the humanized anti-Lewis Y (Le super(y)) monoclonal antibody humanized 3S193 (hu3S193). Experimental Design: The intracellular localization of hu3S193 in Le super(y)-positive MCF-7 breast carcinoma cells was assessed by confocal microscopy. Cytotoxicity of super(213)Bi-hu3S193 and apoptosis was assessed using [ super(3)H]thymidine incorporation assay and ELISA, respectively. Immunoblotting for gamma -H2AX assessed DNA strand breaks. In vivo efficacy of super(213)Bi-hu3S193 was assessed using a minimal residual disease model in BALB/c nude mice, with radioconjugate [15, 30, and 60 mu Ci (9.2 mu g)] injected 2 days after s.c. implantation of MCF-7 cells. Radioimmunotherapy was also combined with a single injection of 300 mu g paclitaxel to explore improved efficacy. Further, mice with established tumors received 30, 60, or 120 mu Ci (14.5 mu g) of super(213)Bi-hu3S193 to assess the effect of tumor volume on treatment efficacy. RESULTS: hu3S193 is internalized via an endosomal and lysosomal trafficking pathway. Treatment with super(213)Bi-hu3S193 results in >90% cytotoxicity in vitro and induces apoptosis and increased gamma -H2AX expression. super(213)Bi-hu3S193 causes specific and significant retardation of tumor growth even in established tumors, and efficacy was enhanced by paclitaxel to produce defined complete responses. CONCLUSIONS: These studies show the potency of alpha -particle radioimmunotherapy and warrant its further exploration in the treatment of micrometastatic disease in Le super(y)-positive malignancies. JF - Clinical Cancer Research AU - Kelly, Marcus P AU - Lee, Fook T AU - Tahtis, Kiki AU - Smyth, Fiona E AU - Brechbiel, Martin W AU - Scott, Andrew M AD - Authors' Affiliations: Tumour Targeting Program, Ludwig Institute for Cancer Research, Austin Hospital, Heidelberg, Victoria, Australia and Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 5604s EP - 5612s PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 13 IS - 18 SN - 1078-0432, 1078-0432 KW - Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Immunoblotting KW - Physical characteristics KW - Enzyme-linked immunosorbent assay KW - Apoptosis KW - Monoclonal antibodies KW - Solid tumors KW - Chemotherapy KW - Animal models KW - Tumors KW - DNA damage KW - Malignancy KW - Cytotoxicity KW - minimal residual disease KW - Paclitaxel KW - Confocal microscopy KW - Radioisotopes KW - Breast carcinoma KW - F 06915:Cancer Immunology KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19787028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Radioimmunotherapy+with+alpha+-Particle-Emitting+super%28213%29Bi-C-Functionalized+trans-Cyclohexyl-Diethylenetriaminepentaacetic+Acid-Humanized+3S193+Is+Enhanced+by+Combination+with+Paclitaxel+Chemotherapy&rft.au=Kelly%2C+Marcus+P%3BLee%2C+Fook+T%3BTahtis%2C+Kiki%3BSmyth%2C+Fiona+E%3BBrechbiel%2C+Martin+W%3BScott%2C+Andrew+M&rft.aulast=Kelly&rft.aufirst=Marcus&rft.date=2007-09-01&rft.volume=13&rft.issue=18&rft.spage=5604s&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Immunoblotting; Enzyme-linked immunosorbent assay; Physical characteristics; Apoptosis; Solid tumors; Monoclonal antibodies; Chemotherapy; Animal models; Tumors; DNA damage; minimal residual disease; Cytotoxicity; Malignancy; Paclitaxel; Confocal microscopy; Radioisotopes; Breast carcinoma ER - TY - JOUR T1 - Inflammatory Breast Cancer: Dynamic Contrast-enhanced MR in Patients Receiving Bevacizumab-Initial Experience AN - 19747556; 7560633 AB - PURPOSE: To retrospectively compare three dynamic contrast material-enhanced magnetic resonance (MR) imaging (dynamic MR imaging) analytic methods to determine the parameter or combination of parameters most strongly associated with changes in tumor microvasculature during treatment with bevacizumab alone and bevacizumab plus chemotherapy in patients with inflammatory or locally advanced breast cancer. MATERIALS AND METHODS: This study was conducted in accordance with the institutional review board of the National Cancer Institute and was compliant with the Privacy Act of 1974. Informed consent was obtained from all patients. Patients with inflammatory or locally advanced breast cancer were treated with one cycle of bevacizumab alone (cycle 1) followed by six cycles of combination bevacizumab and chemotherapy (cycles 2-7). Serial dynamic MR images were obtained, and the kinetic parameters measured by using three dynamic analytic MR methods (heuristic, Brix, and general kinetic models) and two region-of-interest strategies were compared by using two-sided statistical tests. A P value of .01 was required for significance. RESULTS: In 19 patients, with use of a whole-tumor region of interest, the authors observed a significant decrease in the median values of three parameters measured from baseline to cycle 1: forward transfer rate constant (K super(trans)) (-34% relative change, P = .003), backflow compartmental rate constant extravascular and extracellular to plasma (K sub(ep)) (-15% relative change, P < .001), and integrated area under the gadolinium concentration curve (IAUGC) at 180 seconds (-23% relative change, P = .009). A trend toward differences in the heuristic slope of the washout curve between responders and nonresponders to therapy was observed after cycle 1 (bevacizumab alone, P = .02). The median relative change in slope of the wash-in curve from baseline to cycle 4 was significantly different between responders and nonresponders (P = .009). CONCLUSION: The dynamic contrast-enhanced MR parameters K super(trans), K sub(ep), and IAUGC at 180 seconds appear to have the strongest association with early physiologic response to bevacizumab. Clinical trial registration no. NCT00016549 [copy ] RSNA, 2007 JF - Radiology AU - Thukral, Arpi AU - Thomasson, David M AU - Chow, Catherine K AU - Eulate, Reyes AU - Wedam, Suparna B AU - Gupta, Sandeep N AU - Wise, Betty J AU - Steinberg, Seth M AU - Liewehr, David J AU - Choyke, Peter L AU - Swain, Sandra M AD - Medical Oncology Branch (A.T., S.B.W., S. M. Swain), Molecular Imaging Program (R.E., P.L.C.), and Biostatistics and Data Management Section (S. M. Steinberg, D.J.L.), Center for Cancer Research, National Cancer Institute Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 727 EP - 735 PB - Radiological Society of North America, 820 Jorie Blvd. Oak Brook Illinois 60523-2251 USA VL - 244 IS - 3 SN - 0033-8419, 0033-8419 KW - Biotechnology and Bioengineering Abstracts KW - Microvasculature KW - Chemotherapy KW - Gadolinium KW - Magnetic resonance imaging KW - Statistical analysis KW - Tumors KW - Clinical trials KW - Models KW - Inflammation KW - Kinetics KW - Problem solving KW - Breast cancer KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19747556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Inflammatory+Breast+Cancer%3A+Dynamic+Contrast-enhanced+MR+in+Patients+Receiving+Bevacizumab-Initial+Experience&rft.au=Thukral%2C+Arpi%3BThomasson%2C+David+M%3BChow%2C+Catherine+K%3BEulate%2C+Reyes%3BWedam%2C+Suparna+B%3BGupta%2C+Sandeep+N%3BWise%2C+Betty+J%3BSteinberg%2C+Seth+M%3BLiewehr%2C+David+J%3BChoyke%2C+Peter+L%3BSwain%2C+Sandra+M&rft.aulast=Thukral&rft.aufirst=Arpi&rft.date=2007-09-01&rft.volume=244&rft.issue=3&rft.spage=727&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Inflammation; Breast cancer; Magnetic resonance imaging; Kinetics; Statistical analysis; Problem solving; Chemotherapy; Gadolinium; Models; Clinical trials; Tumors; Microvasculature ER - TY - JOUR T1 - Multicenter Study of Acetaminophen Hepatotoxicity Reveals the Importance of Biological Endpoints in Genomic Analyses AN - 19747162; 7561136 AB - Gene expression profiling is a widely used technique with data from the majority of published microarray studies being publicly available. These data are being used for meta-analyses and in silico discovery; however, the comparability of toxicogenomic data generated in multiple laboratories has not been critically evaluated. Using the power of prospective multilaboratory investigations, seven centers individually conducted a common toxicogenomics experiment designed to advance understanding of molecular pathways perturbed in liver by an acute toxic dose of N-acetyl-p-aminophenol (APAP) and to uncover reproducible genomic signatures of APAP-induced toxicity. The nonhepatotoxic APAP isomer N-acetyl-m-aminophenol was used to identify gene expression changes unique to APAP. Our data show that c-Myc is induced by APAP and that c-Myc-centered interactomes are the most significant networks of proteins associated with liver injury. Furthermore, sources of error and data variability among Centers and methods to accommodate this variability were identified by coupling gene expression with extensive toxicological evaluation of the toxic responses. We show that phenotypic anchoring of gene expression data is required for biologically meaningful analysis of toxicogenomic experiments. JF - Toxicological Sciences AU - Beyer, Richard P AU - Fry, Rebecca C AU - Lasarev, Michael R AU - McConnachie, Lisa A AU - Meira, Lisiane B AU - Palmer, Valerie S AU - Powell, Christine L AU - Ross, Pamela K AU - Bammler, Theo K AU - Bradford, Blair U AU - Cranson, Alex B AU - Cunningham, Michael L AU - Fannin, Rickie D AU - Higgins, Gregory M AU - Hurban, Patrick AU - Kayton, Robert J AU - Kerr, Kathleen F AU - Kosyk, Oksana AU - Lobenhofer, Edward K AU - Sieber, Stella O AU - Vliet, Portia A AU - Weis, Brenda K AU - Wolfinger, Russel AU - Woods, Courtney G AU - Freedman, Jonathan H AU - Linney, Elwood AU - Kaufmann, William K AU - Kavanagh, Terrance J AU - Paules, Richard S AU - Rusyn, Ivan AU - Samson, Leona D AU - Spencer, Peter S AU - Suk, William AU - Tennant, Raymond J AU - Zarbl, Helmut AD - University of Washington, Seattle, Washington 98195. Massachusetts Institute of Technology, Cambridge, Massachusetts 02139. Oregon Health & Science University, Portland, Oregon 97239. University of North Carolina, Chapel Hill, North Carolina 27599. National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Cogenics, a Division of Clinical Data, Inc., Morrisville, North Carolina 27560. SAS Institute, Inc., Cary, North Carolina 27513. Duke University Medical Center, Durham, North Carolina 27710. Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 326 EP - 337 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 1 SN - 1096-6080, 1096-6080 KW - Genetics Abstracts; Toxicology Abstracts KW - Gene expression KW - Data processing KW - Injuries KW - Reviews KW - Genomic analysis KW - Liver KW - Toxicity KW - Acetaminophen KW - hepatotoxicity KW - c-Myc protein KW - Isomers KW - X 24310:Pharmaceuticals KW - G 07710:Chemical Mutagenesis & Radiation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19747162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Mitochondrial+toxicity+in+hearts+of+CD-1+mice+following+perinatal+exposure+to+AZT%2C+3TC%2C+or+AZT%2F3TC+in+combination&rft.au=Chan%2C+Sherine+S+L%3BSantos%2C+Janine+H%3BMeyer%2C+Joel+N%3BMandavilli%2C+Bhaskar+S%3BCook+Jr%2C+Dennis+L%3BMcCash%2C+Consuelo+L%3BKissling%2C+Grace+E%3BNyska%2C+Abraham%3BFoley%2C+Julie+F%3Bvan+Houten%2C+Bennett%3BCopeland%2C+William+C%3BWalker%2C+Vernon+E%3BWitt%2C+Kristine+L%3BBishop%2C+Jack+B&rft.aulast=Chan&rft.aufirst=Sherine+S&rft.date=2007-05-01&rft.volume=48&rft.issue=3-4&rft.spage=190&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20191 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gene expression; Data processing; Injuries; Reviews; Genomic analysis; Liver; Toxicity; c-Myc protein; hepatotoxicity; Acetaminophen; Isomers ER - TY - JOUR T1 - Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in the Developing Male Wistar(Han) Rat. II: Chronic Dosing Causes Developmental Delay AN - 19747140; 7561125 AB - We have investigated whether fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes defects in the male reproductive system of the rat using chronically exposed rats to ensure continuous exposure of the fetus. Five- to six-week-old rats were exposed to control diet, or diet containing TCDD, to attain an average dose of 2.4, 8, and 46 ng TCDD/kg/day for 12 weeks, whereupon the rats were mated and allowed to litter; rats were switched to control diet after parturition. Male offsprings were allowed to develop until kills on PND70 (25 per group) or PND120 (all remaining animals). Offspring from the high-dose group showed an increase in total litter loss, and the number of animals alive on postnatal day (PND)4 in the high-dose group was similar to 26% less than control. The high and medium dose offsprings showed decreased weights at various ages. Balano-preputial separation (BPS) was significantly delayed in all three dose groups compared to control. There were no significant effects of maternal treatment when the offsprings were subjected to a functional observational battery or learning tests, with the exception that the high-dose group showed a deficit in motor activity. Twenty rats per group were mated to females, and there were no significant effects of maternal treatment on the fertility of these rats or on the F sub(1) or F sub(2) sex ratio. Sperm parameters at PND70 and 120 showed no significant effect of maternal treatment, with the exception that there was an increase in the proportion of abnormal sperm in the high-dose group at PND70; this is associated with the developmental delay in puberty in this dose group. There were no remarkable findings of maternal treatment on organ weights, with the exception that testis weights were reduced by similar to 10% at PND70 (but not PND120), and although the experiment was sufficiently powered to detect small changes, ventral prostate weight was not reduced. There were no significant effects of maternal treatment upon histopathological comparison of high-dose and control group organs. These data confirm that developmental exposure to TCDD shows no potent effect on adult sperm parameters or accessory sexual organs, but show that delay in BPS occurs after exposure to low doses of TCDD, and this is dependent upon whether TCDD is administered acutely or chronically. JF - Toxicological Sciences AU - Bell, David R AU - Clode, Sally AU - Fan, Ming Qi AU - Fernandes, Alwyn AU - Foster, Paul MD AU - Jiang, Tao AU - Loizou, George AU - MacNicoll, Alan AU - Miller, Brian G AU - Rose, Martin AU - Tran, Lang AU - White, Shaun AD - School of Biology, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. Covance Laboratories Ltd, Otley Road, Harrogate, North Yorkshire, HG3 1PY UK. National Institute of Environmental Health Sciences, PO Box 12233 (MD E1-06), 111 TW Alexander Drive, Research Triangle Park, North Carolina 27709. Health and Safety Laboratory, Harpur Hill, Buxton, Derbyshire, SK17 9JN, UK. Central Science Laboratory, Environment, Food and Health, Sand Hutton, York, YO41 1LZ, UK. Institute of Occupational Medicine, Research Park North, Riccarton, Edinburgh, EH14 4AP, UK Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 224 EP - 233 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 1 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - Testes KW - Diets KW - Fertility KW - Age KW - Sex ratio KW - Parturition KW - TCDD KW - Toxicity KW - Sperm KW - Fetuses KW - Reproductive system KW - Motor activity KW - Observational learning KW - Progeny KW - Prostate KW - Puberty KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19747140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Toxicity+of+2%2C3%2C7%2C8-Tetrachlorodibenzo-p-dioxin+in+the+Developing+Male+Wistar%28Han%29+Rat.+II%3A+Chronic+Dosing+Causes+Developmental+Delay&rft.au=Bell%2C+David+R%3BClode%2C+Sally%3BFan%2C+Ming+Qi%3BFernandes%2C+Alwyn%3BFoster%2C+Paul+MD%3BJiang%2C+Tao%3BLoizou%2C+George%3BMacNicoll%2C+Alan%3BMiller%2C+Brian+G%3BRose%2C+Martin%3BTran%2C+Lang%3BWhite%2C+Shaun&rft.aulast=Bell&rft.aufirst=David&rft.date=2007-09-01&rft.volume=99&rft.issue=1&rft.spage=224&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Diets; Testes; Age; Fertility; Sex ratio; Parturition; TCDD; Sperm; Toxicity; Reproductive system; Fetuses; Motor activity; Progeny; Observational learning; Prostate; Puberty ER - TY - JOUR T1 - Differential Fungicidal Activities of Amphotericin B and Voriconazole against Aspergillus Species Determined by Microbroth Methodology AN - 19741098; 7554007 AB - Antifungal agents may differ in their fungicidal activities against Aspergillus spp. In order to compare the fungicidal activities of voriconazole and amphotericin B against 40 isolates of Aspergillus fumigatus, A. flavus, and A. terreus, we developed a new microbroth colorimetric method for assessing fungicidal activities and determining minimal fungicidal concentrations (MFCs). This methodology follows the antifungal susceptibility testing reference method M-38A for MIC determination. After drug removal and addition of fresh medium, growth of viable conidia adhering to the bottoms of the microtitration wells was assessed by a colorimetric assay of metabolic activity after 24 h of incubation. The new method was faster (six times), reproducible (92 to 97%), and in agreement with culture-based MFCs (91 to 100%). Differential fungicidal activities of voriconazole and amphotericin B were found among the three Aspergillus species, with A. fumigatus and A. flavus having the lowest (1 and 2 mg/liter, respectively) and A. terreus the highest (>16 mg/liter) median amphotericin B MFCs; A. flavus had a lower median voriconazole MFC (4 mg/liter) than the other species (>8 mg/liter; P 4) against 94% of A. fumigatus and 84% of A. terreus isolates. The new methodology revealed a concentration-dependent sigmoid pattern of fungicidal effects, indicating that fungicidal activity is not an all-or-nothing phenomenon and that some degree of fungicidal action can be found even for agents considered fungistatic based on the MFC/MIC ratio. JF - Antimicrobial Agents & Chemotherapy AU - Meletiadis, Joseph AU - Antachopoulos, Charalampos AU - Stergiopoulou, Theodouli AU - Pournaras, Spyros AU - Roilides, Emmanuel AU - Walsh, Thomas J AD - Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland. Department of Clinical Microbiology, University of Thessalia, Larissa, Greece. Third Department of Pediatrics, Aristotle University, Hippokration Hospital, Thessaloniki, Greece Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 3329 EP - 3337 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 51 IS - 9 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Amphotericin B KW - Antifungal agents KW - Aspergillus flavus KW - Aspergillus fumigatus KW - Fungicidal activity KW - Voriconazole KW - Colorimetry KW - Conidia KW - Minimum inhibitory concentration KW - Drugs KW - K 03340:Effects of Physical & Chemical Factors KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19741098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Differential+Fungicidal+Activities+of+Amphotericin+B+and+Voriconazole+against+Aspergillus+Species+Determined+by+Microbroth+Methodology&rft.au=Meletiadis%2C+Joseph%3BAntachopoulos%2C+Charalampos%3BStergiopoulou%2C+Theodouli%3BPournaras%2C+Spyros%3BRoilides%2C+Emmanuel%3BWalsh%2C+Thomas+J&rft.aulast=Meletiadis&rft.aufirst=Joseph&rft.date=2007-09-01&rft.volume=51&rft.issue=9&rft.spage=3329&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Amphotericin B; Antifungal agents; Voriconazole; Fungicidal activity; Colorimetry; Conidia; Drugs; Minimum inhibitory concentration; Aspergillus flavus; Aspergillus fumigatus ER - TY - JOUR T1 - Phase I Study of SS1P, a Recombinant Anti-Mesothelin Immunotoxin Given as a Bolus I.V. Infusion to Patients with Mesothelin-Expressing Mesothelioma, Ovarian, and Pancreatic Cancers AN - 19739561; 7556257 AB - PURPOSE: To determine the toxicities, maximum tolerated dose (MTD) and pharmacokinetics of the recombinant immunotoxin SS1P (anti-mesothelin dsFv-PE38) in patients with mesothelin-expressing cancers. Experimental Design: SS1P given as a 30-min i.v. infusion every other day (QOD) for six or three doses was administered to 34 patients with advanced mesothelioma (n = 20), ovarian (n = 12), and pancreatic (n = 2) cancer. RESULTS: The initial cohort of 17 patients received SS1P QOD x 6 doses and the MTD was 18 mu g/kg/dose. Dose-limiting toxicities (DLT) included grade 3 uticaria (one patient) and grade 3 vascular leak syndrome (two patients). To allow further SS1P dose escalation, 17 patients were treated on the QOD x 3 schedule and the MTD was 45 mu g/kg/dose. The DLT was grade 3 pleuritis and was seen in two of two patients treated at a dose of 60 mu g/kg and in one of nine patients treated at a dose of 45 mu g/kg. At the MTD of 45 mu g/kg, the mean C sub(max) of SS1P was 483 ng/mL and half-life was 466 min. Of the 33 evaluable patients treated, 4 had minor responses, 19 had stable disease (including 2 with resolution of ascites), and 10 had progressive disease. CONCLUSIONS: SS1P is well tolerated with pleuritis as the DLT at the highest dose level. Evidence of clinical activity was noted in a group of heavily pretreated patients. Phase II clinical trials of SS1P are being planned for malignant mesothelioma and other mesothelin-expressing malignancies. JF - Clinical Cancer Research AU - Hassan, Raffit AU - Bullock, Susie AU - Premkumar, Ahalya AU - Kreitman, Robert J AU - Kindler, Hedy AU - Willingham, Mark C AU - Pastan, Ira AD - Authors' Affiliations: Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute and Clinical Center, NIH, Bethesda, Maryland Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - 5144 EP - 5149 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 13 IS - 17 SN - 1078-0432, 1078-0432 KW - Toxicology Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Malignancy KW - Pleurisy KW - vascular leak syndrome KW - Ascites KW - Pancreatic cancer KW - mesothelioma KW - Toxicity KW - Clinical trials KW - Immunotoxins KW - Pharmacokinetics KW - W 30925:Genetic Engineering KW - X 24310:Pharmaceuticals KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19739561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Phase+I+Study+of+SS1P%2C+a+Recombinant+Anti-Mesothelin+Immunotoxin+Given+as+a+Bolus+I.V.+Infusion+to+Patients+with+Mesothelin-Expressing+Mesothelioma%2C+Ovarian%2C+and+Pancreatic+Cancers&rft.au=Hassan%2C+Raffit%3BBullock%2C+Susie%3BPremkumar%2C+Ahalya%3BKreitman%2C+Robert+J%3BKindler%2C+Hedy%3BWillingham%2C+Mark+C%3BPastan%2C+Ira&rft.aulast=Hassan&rft.aufirst=Raffit&rft.date=2007-09-01&rft.volume=13&rft.issue=17&rft.spage=5144&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Malignancy; Pleurisy; vascular leak syndrome; Ascites; Pancreatic cancer; mesothelioma; Toxicity; Clinical trials; Pharmacokinetics; Immunotoxins ER - TY - JOUR T1 - Effects of Gamma Radiation on Fc epsilon RI and TLR-Mediated Mast Cell Activation AN - 19739019; 7558709 AB - Ionizing gamma radiation has several therapeutic indications including bone marrow transplantation and tumor ablation. Among immune cells, susceptibility of lymphocytes to gamma radiation is well known. However, there is little information on the effects of gamma radiation on mast cells, which are important in both innate and acquired immunity. Previous studies have suggested that mast cells may release histamine in response to high doses of gamma radiation, whereas other reports suggest that mast cells are relatively radioresistant. No strong link has been established between gamma radiation and its effect on mast cell survival and activation. We examined both human and murine mast cell survival and activation, including mechanisms related to innate and acquired immune responses following gamma radiation. Data revealed that human and murine mast cells were resistant to gamma radiation-induced cytotoxicity and, importantly, that irradiation did not directly induce beta -hexosaminidase release. Instead, a transient attenuation of IgE-mediated beta -hexosaminidase release and cytokine production was observed which appeared to be the result of reactive oxygen species formation after irradiation. Mast cells retained the ability to phagocytose Escherichia coli particles and respond to TLR ligands as measured by cytokine production after irradiation. In vivo, there was no decrease in mast cell numbers in skin of irradiated mice. Additionally, mast cells retained the ability to respond to Ag in vivo as measured by passive cutaneous anaphylaxis in mice after irradiation. Mast cells are thus resistant to the cytotoxic effects and alterations in function after irradiation and, despite a transient inhibition, ultimately respond to innate and acquired immune activation signals. JF - Journal of Immunology AU - Soule, Benjamin P AU - Brown, Jared M AU - Kushnir-Sukhov, Nataliya M AU - Simone, Nicole L AU - Mitchell, James B AU - Metcalfe, Dean D AD - Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - 3276 EP - 3286 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 179 IS - 5 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Cell survival KW - Skin KW - double prime Fc receptors KW - Bone marrow KW - Mast cells KW - Immunity KW - Passive cutaneous anaphylaxis KW - Lymphocytes KW - beta N- double prime Acetylhexosaminidase KW - Cell activation KW - Histamine KW - Cytotoxicity KW - Reactive oxygen species KW - Allografts KW - Escherichia coli KW - gamma Radiation KW - Cytokines KW - Bone marrow transplantation KW - F 06955:Immunomodulation & Immunopharmacology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19739019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Effects+of+Gamma+Radiation+on+Fc+epsilon+RI+and+TLR-Mediated+Mast+Cell+Activation&rft.au=Soule%2C+Benjamin+P%3BBrown%2C+Jared+M%3BKushnir-Sukhov%2C+Nataliya+M%3BSimone%2C+Nicole+L%3BMitchell%2C+James+B%3BMetcalfe%2C+Dean+D&rft.aulast=Soule&rft.aufirst=Benjamin&rft.date=2007-09-01&rft.volume=179&rft.issue=5&rft.spage=3276&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell survival; Skin; double prime Fc receptors; Bone marrow; Mast cells; Lymphocytes; Passive cutaneous anaphylaxis; Immunity; Histamine; Cell activation; beta N- double prime Acetylhexosaminidase; Cytotoxicity; Reactive oxygen species; Allografts; gamma Radiation; Cytokines; Bone marrow transplantation; Escherichia coli ER - TY - JOUR T1 - Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in the Developing Male Wistar(Han) Rat. I: No Decrease in Epididymal Sperm Count after a Single Acute Dose AN - 19736470; 7561124 AB - It has been reported that fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes defects in the male reproductive system of the rat. We set out to replicate and extend these effects using a robust experimental design. Groups of 75 (control vehicle) or 55 (50, 200, or 1000 ng of TCDD/kg bodyweight) female Wistar(Han) rats were exposed to TCDD on gestational day (GD)15, then allowed to litter. The high-dose group dams showed no sustained weight loss compared to control, but four animals had total litter loss. Pups in the high-dose group showed reduced body weight up till day 21, and pups in the medium dose group showed reduced body weight in the first week postpartum. Balano-preputial separation was significantly delayed in the high-dose group male offspring. There were no significant effects of treatment when the offspring were subjected to a functional observational battery or mated with females to assess reproductive capability. Twenty-five males per group were killed on postnatal day (PND) 70, and similar to 60 animals per group ( similar to 30 for the high-dose group) on PND120 to assess seminology and other end points. At PND120, the two highest dose groups showed a statistically significant elevation of sperm counts, compared to control; however, this effect was small ( similar to 30%), within the normal range of sperm counts for this strain of rat, was not reflected in testicular spermatid counts nor PND70 data, and is therefore postulated to have no biological significance. Although there was an increase in the proportion of abnormal sperm at PND70, seminology parameters were otherwise unremarkable. Testis weights in the high-dose group were slightly decreased at PND70 and 120, and at PND120, brain weights were decreased in the high-dose group, liver to body weight ratios were increased for all three dose groups, with an increase in inflammatory cell foci in the epididymis in the high-dose group. These data show that TCDD is a potent developmental toxin after exposure of the developing fetus but that acute developmental exposure to TCDD on GD15 caused no decrease in sperm counts. JF - Toxicological Sciences AU - Bell, David R AU - Clode, Sally AU - Fan, Ming Qi AU - Fernandes, Alwyn AU - Foster, Paul MD AU - Jiang, Tao AU - Loizou, George AU - MacNicoll, Alan AU - Miller, Brian G AU - Rose, Martin AU - Tran, Lang AU - White, Shaun AD - School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK. Covance Laboratories Ltd, Otley Road, Harrogate, North Yorkshire, HG3 1PY, UK. National Institute of Environmental Health Sciences, PO Box 12233 (MD E1-06), 111 TW Alexander Drive, Research Triangle Park, North Carolina 27709. Health and Safety Laboratory, Harpur Hill, Buxton, Derbyshire, SK17 9JN, UK. Central Science Laboratory, Environment, Food and Health, Sand Hutton, York, YO41 1LZ, UK. Institute of Occupational Medicine, Research Park North, Riccarton, Edinburgh, EH14 4AP, UK Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 214 EP - 223 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 1 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - Testes KW - Epididymis KW - Brain KW - Statistical analysis KW - TCDD KW - Toxicity KW - Sperm KW - Toxins KW - Fetuses KW - Reproductive system KW - Inflammation KW - Postpartum KW - Body weight KW - Spermatids KW - Liver KW - Progeny KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19736470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Toxicity+of+2%2C3%2C7%2C8-Tetrachlorodibenzo-p-dioxin+in+the+Developing+Male+Wistar%28Han%29+Rat.+I%3A+No+Decrease+in+Epididymal+Sperm+Count+after+a+Single+Acute+Dose&rft.au=Bell%2C+David+R%3BClode%2C+Sally%3BFan%2C+Ming+Qi%3BFernandes%2C+Alwyn%3BFoster%2C+Paul+MD%3BJiang%2C+Tao%3BLoizou%2C+George%3BMacNicoll%2C+Alan%3BMiller%2C+Brian+G%3BRose%2C+Martin%3BTran%2C+Lang%3BWhite%2C+Shaun&rft.aulast=Bell&rft.aufirst=David&rft.date=2007-09-01&rft.volume=99&rft.issue=1&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Testes; Epididymis; Statistical analysis; Brain; TCDD; Sperm; Toxicity; Reproductive system; Fetuses; Toxins; Inflammation; Postpartum; Spermatids; Body weight; Liver; Progeny ER - TY - JOUR T1 - Multicopy plasmid modification with phage lambda Red recombineering AN - 19540422; 8242091 AB - Recombineering, in vivo genetic engineering using the bacteriophage lambda Red generalized recombination system, was used to create various modifications of a multicopy plasmid derived from pBR322. All genetic modifications possible on the Escherichia coli chromosome and on bacterial artificial chromosomes (BACs) are also possible on multicopy plasmids and are obtained with similar frequencies to their chromosomal counterparts, including creation of point mutations (5-10% unselected frequency), deletions and substitutions. Parental and recombinant plasmids are nearly always present as a mixture following recombination, and circular multimeric plasmid molecules are often generated during the recombineering. JF - Plasmid AU - Thomason, L C AU - Costantino, N AU - Shaw, D V AU - Court, D L AD - Building 539, Room 243, National Cancer Institute at Frederick, Frederick, MD 21702, USA, lthomason@ncifcrf.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 148 EP - 158 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 58 IS - 2 SN - 0147-619X, 0147-619X KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Phages KW - Bacterial artificial chromosomes KW - Recombination KW - Chromosomes KW - Genetic engineering KW - Chromosome deletion KW - Point mutation KW - Escherichia coli KW - Phage l KW - Plasmids KW - J 02410:Animal Diseases KW - W 30925:Genetic Engineering KW - V 22410:Animal Diseases KW - G 07760:Viruses & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19540422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Plasmid&rft.atitle=Multicopy+plasmid+modification+with+phage+lambda+Red+recombineering&rft.au=Thomason%2C+L+C%3BCostantino%2C+N%3BShaw%2C+D+V%3BCourt%2C+D+L&rft.aulast=Thomason&rft.aufirst=L&rft.date=2007-09-01&rft.volume=58&rft.issue=2&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Plasmid&rft.issn=0147619X&rft_id=info:doi/10.1016%2Fj.plasmid.2007.03.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Bacterial artificial chromosomes; Phages; Recombination; Chromosomes; Genetic engineering; Point mutation; Chromosome deletion; Plasmids; Escherichia coli; Phage l DO - http://dx.doi.org/10.1016/j.plasmid.2007.03.001 ER - TY - JOUR T1 - Cutting Edge: Peyer's Patch Plasmacytoid Dendritic Cells (pDCs) Produce Low Levels of Type I Interferons: Possible Role for IL-10, TGF beta , and Prostaglandin E sub(2) in Conditioning a Unique Mucosal pDC Phenotype AN - 19458168; 7558645 AB - The organized lymphoid tissues of the intestine likely play an important role in the balance between tolerance harmless mucosal Ags and commensal bacteria and immunity to mucosal pathogens. We examined the phenotype and function of plasmacytoid dendritic cells (pDCs) from murine Peyer's patches (PPs). When stimulated with CpG-enriched oligodeoxynucleotides in vitro, PPs and spleen pDCs made equivalent levels of IL-12, yet PP pDCs were incapable of producing significant levels of type I IFNs. Three regulatory factors associated with mucosal tissues, PGE sub(2), IL-10, and TGF beta , inhibited the ability of spleen pDCs to produce type I IFN in a dose-dependent fashion. These studies suggest that mucosal factors may regulate the production of type I IFN as well as IL-12 by pDCs. In the intestine, this may be beneficial in preventing harmful innate and adaptive immune responses to commensal microorganisms. JF - Journal of Immunology AU - Contractor, Nikhat AU - Louten, Jennifer AU - Kim, Leesun AU - Biron, Christine A AU - Kelsall, Brian L AD - Mucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892. Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912. Wyeth Nutrition, Collegeville, PA 19426. Schering-Plough Biopharma, Palo Alto, CA 94304 Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - 2690 EP - 2694 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 179 IS - 5 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Peyer's patches KW - Mucosal immunity KW - Mucosa KW - Commensals KW - Spleen KW - Pathogens KW - Prostaglandin E2 KW - Oligonucleotides KW - Immunological tolerance KW - Interleukin 10 KW - Lymphoid tissue KW - Dendritic cells KW - Interleukin 12 KW - Interferon KW - Transforming growth factor- beta KW - Intestine KW - Microorganisms KW - Immune response KW - A 01490:Miscellaneous KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19458168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Cutting+Edge%3A+Peyer%27s+Patch+Plasmacytoid+Dendritic+Cells+%28pDCs%29+Produce+Low+Levels+of+Type+I+Interferons%3A+Possible+Role+for+IL-10%2C+TGF+beta+%2C+and+Prostaglandin+E+sub%282%29+in+Conditioning+a+Unique+Mucosal+pDC+Phenotype&rft.au=Contractor%2C+Nikhat%3BLouten%2C+Jennifer%3BKim%2C+Leesun%3BBiron%2C+Christine+A%3BKelsall%2C+Brian+L&rft.aulast=Contractor&rft.aufirst=Nikhat&rft.date=2007-09-01&rft.volume=179&rft.issue=5&rft.spage=2690&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Peyer's patches; Mucosal immunity; Mucosa; Commensals; Spleen; Prostaglandin E2; Pathogens; Immunological tolerance; Oligonucleotides; Lymphoid tissue; Interleukin 10; Interferon; Interleukin 12; Dendritic cells; Transforming growth factor- beta; Microorganisms; Intestine; Immune response ER - TY - JOUR T1 - OC144: Clinical significance of the presence of amniotic fluid sludge in patients with cervical cerclage AN - 19283404; 8634598 AB - Abstract not available. JF - Ultrasound in Obstetrics and Gynecology AU - Kusanovic, J P AU - Romero, R AU - Espinoza, J AU - Goncalves, L F AU - Gotsch, F AU - Camacho, N AU - Lee, W AU - Erez, O AU - Schoen, M L AU - Hassan, S AD - Perinatology Research Branch, Intramural Division, National Institute of Child Health and Human Development, NIH, DHHS, United States Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 411 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 30 IS - 4 SN - 0960-7692, 0960-7692 KW - Biotechnology and Bioengineering Abstracts KW - Amniotic fluid KW - Gynecology KW - Sludges KW - Ultrasound KW - Obstetrics KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19283404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=OC144%3A+Clinical+significance+of+the+presence+of+amniotic+fluid+sludge+in+patients+with+cervical+cerclage&rft.au=Kusanovic%2C+J+P%3BRomero%2C+R%3BEspinoza%2C+J%3BGoncalves%2C+L+F%3BGotsch%2C+F%3BCamacho%2C+N%3BLee%2C+W%3BErez%2C+O%3BSchoen%2C+M+L%3BHassan%2C+S&rft.aulast=Kusanovic&rft.aufirst=J&rft.date=2007-09-01&rft.volume=30&rft.issue=4&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=09607692&rft_id=info:doi/10.1002%2Fuog.4250 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Obstetrics; Amniotic fluid; Gynecology; Sludges; Ultrasound DO - http://dx.doi.org/10.1002/uog.4250 ER - TY - JOUR T1 - Inter- alpha -Trypsin Inhibitor Attenuates Complement Activation and Complement-Induced Lung Injury AN - 17279455; 7614922 AB - Complement activation is a central component of inflammation and sepsis and can lead to significant tissue injury. Complement factors are serum proteins that work through a cascade of proteolytic reactions to amplify proinflammatory signals. Inter- alpha -trypsin inhibitor (IaI) is an abundant serum protease inhibitor that contains potential complement-binding domains, and has been shown to improve survival in animal sepsis models. We hypothesized that IaI can bind complement and inhibit complement activation, thus ameliorating complement-dependent inflammation. We evaluated this hypothesis with in vitro complement activation assays and in vivo in a murine model of complement-dependent lung injury. We found that IaI inhibited complement activation through the classical and alternative pathways, inhibited complement-dependent phagocytosis in vitro, and reduced complement-dependent lung injury in vivo. This novel function of IaI provides a mechanistic explanation for its observed salutary effects in sepsis and opens new possibilities for its use as a treatment agent in inflammatory diseases. JF - Journal of Immunology AU - Garantziotis, Stavros AU - Hollingsworth, John W AU - Ghanayem, Rami B AU - Timberlake, Sarah AU - Zhuo, Lisheng AU - Kimata, Koji AU - Schwartz, David A AD - Department of Medicine, Duke University Medical Center, Durham, NC 27710. National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. North Carolina State University, Raleigh, NC 27695. Institute for Molecular Science of Medicine, Aichi Medical University, Aichi, Japan Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 4187 EP - 4192 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 179 IS - 6 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Proteolysis KW - Injuries KW - Proteinase inhibitors KW - Animal models KW - Survival KW - Serum proteins KW - Inflammation KW - Alternative pathway KW - Sepsis KW - Inflammatory diseases KW - Lung KW - Complement activation KW - Phagocytosis KW - J 02350:Immunology KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17279455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Inter-+alpha+-Trypsin+Inhibitor+Attenuates+Complement+Activation+and+Complement-Induced+Lung+Injury&rft.au=Garantziotis%2C+Stavros%3BHollingsworth%2C+John+W%3BGhanayem%2C+Rami+B%3BTimberlake%2C+Sarah%3BZhuo%2C+Lisheng%3BKimata%2C+Koji%3BSchwartz%2C+David+A&rft.aulast=Garantziotis&rft.aufirst=Stavros&rft.date=2007-09-01&rft.volume=179&rft.issue=6&rft.spage=4187&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Proteolysis; Injuries; Proteinase inhibitors; Animal models; Survival; Inflammation; Serum proteins; Alternative pathway; Sepsis; Inflammatory diseases; Lung; Complement activation; Phagocytosis ER - TY - JOUR T1 - Gene expression profiling reveals different pathways related to Abl and other genes that cooperate with c-Myc in a model of plasma cell neoplasia. AN - 68428160; 17764563 AB - To elucidate the genes involved in the neoplastic transformation of B cells, global gene expression profiles were generated using Affymetrix U74Av2 microarrays, containing 12,488 genes, for four different groups of mouse B-cell lymphomas and six subtypes of pristane-induced mouse plasma cell tumors, three of which developed much earlier than the others. Unsupervised hierarchical cluster analysis exhibited two main sub-clusters of samples: a B-cell lymphoma cluster and a plasma cell tumor cluster with subclusters reflecting mechanism of induction. This report represents the first step in using global gene expression to investigate molecular signatures related to the role of cooperating oncogenes in a model of Myc-induced carcinogenesis. Within a single subgroup, e.g., ABPCs, plasma cell tumors that contained typical T(12;15) chromosomal translocations did not display gene expression patterns distinct from those with variant T(6;15) translocations, in which the breakpoint was in the Pvt-1 locus, 230 kb 3' of c-Myc, suggesting that c-Myc activation was the initiating factor in both. When integrated with previously published Affymetrix array data from human multiple myelomas, the IL-6-transgenic subset of mouse plasma cell tumors clustered more closely with MM1 subsets of human myelomas, slow-appearing plasma cell tumors clustered together with MM2, while plasma cell tumors accelerated by v-Abl clustered with the more aggressive MM3-MM4 myeloma subsets. Slow-appearing plasma cell tumors expressed Socs1 and Socs2 but v-Abl-accelerated plasma cell tumors expressed 4-5 times as much. Both v-Abl-accelerated and non-v-Abl-associated tumors exhibited phosphorylated STAT 1 and 3, but only v-Abl-accelerated plasma cell tumors lost viability and STAT 1 and 3 phosphorylation when cultured in the presence of the v-Abl kinase inhibitor, STI-571. These data suggest that the Jak/Stat pathway was critical in the transformation acceleration by v-Abl and that v-Abl activity remained essential throughout the life of the tumors, not just in their acceleration. A different pathway appears to predominate in the more slowly arising plasma cell tumors. Gene expression profiling differentiates not only B-cell lymphomas from plasma cell tumors but also distinguishes slow from accelerated plasma cell tumors. These data and those obtained from the sensitivity of v-Abl-accelerated plasma cell tumors and their phosphorylated STAT proteins indicate that these similar tumors utilize different signaling pathways but share a common initiating genetic lesion, a c-Myc-activating chromosome translocation. JF - BMC genomics AU - Park, Eun Sung AU - Shaughnessy, John D AU - Gupta, Shalu AU - Wang, Hongyang AU - Lee, Ju-Seog AU - Woo, Hyun Goo AU - Zhan, Fenghuang AU - Owens, James D AU - Potter, Michael AU - Janz, Siegfried AU - Mushinski, J Frederic AD - Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. espark@mdanderson.org Y1 - 2007/08/31/ PY - 2007 DA - 2007 Aug 31 SP - 302 VL - 8 KW - Benzamides KW - 0 KW - Piperazines KW - Pyrimidines KW - STAT Transcription Factors KW - Imatinib Mesylate KW - 8A1O1M485B KW - Index Medicus KW - Animals KW - Multiple Myeloma -- genetics KW - Humans KW - Pyrimidines -- pharmacology KW - Cell Line, Tumor KW - Mice KW - STAT Transcription Factors -- antagonists & inhibitors KW - Mice, Inbred BALB C KW - Piperazines -- pharmacology KW - Models, Biological KW - Lymphoma, B-Cell -- metabolism KW - Gene Expression Profiling KW - Signal Transduction -- genetics KW - Gene Expression Regulation, Neoplastic KW - Neoplasms, Plasma Cell -- genetics KW - Genes, myc KW - Genes, abl UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68428160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+genomics&rft.atitle=Gene+expression+profiling+reveals+different+pathways+related+to+Abl+and+other+genes+that+cooperate+with+c-Myc+in+a+model+of+plasma+cell+neoplasia.&rft.au=Park%2C+Eun+Sung%3BShaughnessy%2C+John+D%3BGupta%2C+Shalu%3BWang%2C+Hongyang%3BLee%2C+Ju-Seog%3BWoo%2C+Hyun+Goo%3BZhan%2C+Fenghuang%3BOwens%2C+James+D%3BPotter%2C+Michael%3BJanz%2C+Siegfried%3BMushinski%2C+J+Frederic&rft.aulast=Park&rft.aufirst=Eun&rft.date=2007-08-31&rft.volume=8&rft.issue=&rft.spage=302&rft.isbn=&rft.btitle=&rft.title=BMC+genomics&rft.issn=1471-2164&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-06 N1 - Date created - 2007-10-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Immunol. 2002 Mar;3(3):288-94 [11836527] Blood. 2002 Mar 1;99(5):1745-57 [11861292] Oncogene. 2002 Jun 27;21(28):4351-62 [12080466] Blood. 2002 Sep 15;100(6):2175-86 [12200383] Int J Cancer. 2002 Oct 10;101(5):423-6 [12216069] Blood. 2003 Feb 1;101(3):1128-40 [12393520] Blood. 2003 Apr 1;101(7):2784-8 [12456503] Blood. 2003 May 15;101(10):4013-21 [12543863] Blood. 2003 Jul 15;102(2):592-600 [12663452] Immunol Rev. 2003 Aug;194:19-28 [12846804] Immunol Rev. 2003 Aug;194:177-95 [12846815] Cancer Cell. 2003 Sep;4(3):223-38 [14522256] J Clin Invest. 2004 Jun;113(12):1763-73 [15199411] Mol Cell. 2004 Aug 13;15(3):329-41 [15304214] Science. 1973 Nov 9;182(4112):592-4 [4355680] Adv Cancer Res. 1986;47:189-234 [3096089] Proc Natl Acad Sci U S A. 1988 Aug;85(16):6067-71 [3137564] Proc Natl Acad Sci U S A. 1989 Oct;86(19):7547-51 [2798426] Proc Natl Acad Sci U S A. 1989 Dec;86(24):9941-5 [2690079] Mol Cell Biol. 1990 Aug;10(8):4365-9 [2164639] Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8735-9 [1924333] Carcinogenesis. 1992 Oct;13(10):1681-97 [1423827] Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7361-5 [8346257] Nat Med. 1996 May;2(5):561-6 [8616716] Nat Genet. 2004 Dec;36(12):1306-11 [15565109] Bioinformatics. 2004 Dec 12;20(18):3710-5 [15297299] Cell Cycle. 2004 Dec;3(12):1486-8 [15611644] Cancer Res. 2005 Feb 15;65(4):1306-15 [15735016] Cancer Res. 2005 Sep 1;65(17):7644-52 [16140930] Leukemia. 2006 Jun;20(6):1047-54 [16598311] Blood. 2006 Sep 15;108(6):2020-8 [16728703] Oncogene. 2000 May 15;19(21):2523-31 [10851051] Leukemia. 2000 Jun;14(6):1127-35 [10865979] Neoplasia. 1999 Aug;1(3):241-52 [10935479] N Engl J Med. 2001 Apr 5;344(14):1031-7 [11287972] Nat Immunol. 2001 Dec;2(12):1103-8 [11725300] Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1509-14 [11805288] Methods. 2001 Dec;25(4):402-8 [11846609] Curr Opin Hematol. 2002 Jul;9(4):333-8 [12042708] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Endogenous erythropoietin signaling is required for normal neural progenitor cell proliferation. AN - 68204986; 17604282 AB - Erythropoietin (Epo) and its receptor (EpoR), critical for erythropoiesis, are expressed in the nervous system. Prior to death in utero because of severe anemia EpoR-null mice have fewer neural progenitor cells, and differentiated neurons are markedly sensitive to hypoxia, suggesting that during development Epo stimulates neural cell proliferation and prevents neuron apoptosis by promoting oxygen delivery to brain or by direct interaction with neural cells. Here we present evidence that neural progenitor cells express EpoR at higher levels compared with mature neurons; that Epo stimulates proliferation of embryonic neural progenitor cells; and that endogenous Epo contributes to neural progenitor cell proliferation and maintenance. EpoR-null mice were rescued with selective EpoR expression driven by the endogenous EpoR promoter in hematopoietic tissue but not in brain. Although these mice exhibited normal hematopoiesis and erythrocyte production and survived to adulthood, neural cell proliferation and viability were affected. Embryonic brain exhibited increased neural cell apoptosis, and neural cell proliferation was reduced in the adult hippocampus and subventricular zone. Neural cells from these animals were more sensitive to hypoxia/glutamate neurotoxicity than normal neurons in culture and in vivo. These observations demonstrate that endogenous Epo/EpoR signaling promotes cell survival in embryonic brain and contributes to neural cell proliferation in adult brain in regions associated with neurogenesis. Therefore, Epo exerts extra-hematopoietic function and contributes directly to brain development, maintenance, and repair by promoting cell survival and proliferation independent of insult, injury, or ischemia. JF - The Journal of biological chemistry AU - Chen, Zhi-Yong AU - Asavaritikrai, Pundit AU - Prchal, Josef T AU - Noguchi, Constance Tom AD - Molecular Medicine Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-1822, USA. Y1 - 2007/08/31/ PY - 2007 DA - 2007 Aug 31 SP - 25875 EP - 25883 VL - 282 IS - 35 SN - 0021-9258, 0021-9258 KW - Receptors, Erythropoietin KW - 0 KW - Erythropoietin KW - 11096-26-7 KW - Index Medicus KW - Signal Transduction -- physiology KW - Promoter Regions, Genetic -- physiology KW - Animals KW - Mice, Mutant Strains KW - Erythropoiesis -- physiology KW - Hypoxia-Ischemia, Brain -- pathology KW - Organ Specificity -- physiology KW - Mice KW - Hypoxia-Ischemia, Brain -- metabolism KW - Cell Hypoxia KW - Cell Survival -- physiology KW - Stem Cells -- cytology KW - Neurons -- metabolism KW - Receptors, Erythropoietin -- metabolism KW - Cell Differentiation -- physiology KW - Brain -- cytology KW - Apoptosis -- physiology KW - Neurons -- cytology KW - Brain -- embryology KW - Brain -- metabolism KW - Stem Cells -- metabolism KW - Receptors, Erythropoietin -- deficiency KW - Cell Proliferation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68204986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Endogenous+erythropoietin+signaling+is+required+for+normal+neural+progenitor+cell+proliferation.&rft.au=Chen%2C+Zhi-Yong%3BAsavaritikrai%2C+Pundit%3BPrchal%2C+Josef+T%3BNoguchi%2C+Constance+Tom&rft.aulast=Chen&rft.aufirst=Zhi-Yong&rft.date=2007-08-31&rft.volume=282&rft.issue=35&rft.spage=25875&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-29 N1 - Date created - 2007-08-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Fabry Disease: What Pediatric Nephrologists should Know? T2 - 14th Congress of the International Pediatric Nephrology Association (IPNA 2007) AN - 39422996; 4646330 JF - 14th Congress of the International Pediatric Nephrology Association (IPNA 2007) AU - Cho, M Y1 - 2007/08/31/ PY - 2007 DA - 2007 Aug 31 KW - Pediatrics KW - Fabry's disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39422996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Congress+of+the+International+Pediatric+Nephrology+Association+%28IPNA+2007%29&rft.atitle=Fabry+Disease%3A+What+Pediatric+Nephrologists+should+Know%3F&rft.au=Cho%2C+M&rft.aulast=Cho&rft.aufirst=M&rft.date=2007-08-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Congress+of+the+International+Pediatric+Nephrology+Association+%28IPNA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ipna2007.com/final_programme/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Preeclampsia and maternal breast cancer risk by offspring gender: do elevated androgen concentrations play a role? AN - 954574550; 13760132 AB - Among older mothers, preeclampsia in the first pregnancy was associated with a reduction in maternal breast cancer risk that was significantly more pronounced in women bearing male than female infants. Androgen concentrations in male, preeclamptic pregnancies were consistent with the hypothesis that elevated pregnancy androgens might mediate this apparent modifying effect of fetal gender.British Journal of Cancer (2007) 97, 688-690. doi:10.1038/sj.bjc.6603921 www.bjcancer.com Published online 7 August 2007 JF - British Journal of Cancer AU - Troisi, R AU - Innes, K E AU - Roberts, J M AU - Hoover, R N AD - [1] 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA [2] 2 Department of Community and Family Medicine, Dartmouth Medical School, Hanover, NH, USA Y1 - 2007/08/28/ PY - 2007 DA - 2007 Aug 28 SP - 688 EP - 690 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 97 IS - 5 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - Cancer KW - Pregnancy KW - Gender KW - Breast cancer KW - offspring KW - Infants KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954574550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Preeclampsia+and+maternal+breast+cancer+risk+by+offspring+gender%3A+do+elevated+androgen+concentrations+play+a+role%3F&rft.au=Troisi%2C+R%3BInnes%2C+K+E%3BRoberts%2C+J+M%3BHoover%2C+R+N&rft.aulast=Troisi&rft.aufirst=R&rft.date=2007-08-28&rft.volume=97&rft.issue=5&rft.spage=688&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6603921 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Gender; Breast cancer; Cancer; Infants; offspring; Pregnancy DO - http://dx.doi.org/10.1038/sj.bjc.6603921 ER - TY - CPAPER T1 - Number of Axillary Lymph Nodes Dissected is not Affected after Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer T2 - 42nd World Congress of Surgery of the International Society of Surgery ISS/SIC (International Surgical Week) (ISW 2007) AN - 39394739; 4622693 JF - 42nd World Congress of Surgery of the International Society of Surgery ISS/SIC (International Surgical Week) (ISW 2007) AU - Youssef, O AU - Mohamed, A G AU - Anwar, H AU - Gouda, I AU - Mansour, O AU - Hamimi, W Y1 - 2007/08/26/ PY - 2007 DA - 2007 Aug 26 KW - Chemotherapy KW - Lymph nodes KW - Breast cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39394739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=42nd+World+Congress+of+Surgery+of+the+International+Society+of+Surgery+ISS%2FSIC+%28International+Surgical+Week%29+%28ISW+2007%29&rft.atitle=Number+of+Axillary+Lymph+Nodes+Dissected+is+not+Affected+after+Neoadjuvant+Chemotherapy+for+Locally+Advanced+Breast+Cancer&rft.au=Youssef%2C+O%3BMohamed%2C+A+G%3BAnwar%2C+H%3BGouda%2C+I%3BMansour%2C+O%3BHamimi%2C+W&rft.aulast=Youssef&rft.aufirst=O&rft.date=2007-08-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=42nd+World+Congress+of+Surgery+of+the+International+Society+of+Surgery+ISS%2FSIC+%28International+Surgical+Week%29+%28ISW+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isw2007.com/Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Breast Cancer in Young Women (35 Years or Younger): Features of Disease Presentation in a Developing Country T2 - 42nd World Congress of Surgery of the International Society of Surgery ISS/SIC (International Surgical Week) (ISW 2007) AN - 39357834; 4622694 JF - 42nd World Congress of Surgery of the International Society of Surgery ISS/SIC (International Surgical Week) (ISW 2007) AU - Youssef, O AU - Hassan, N AU - Nouh, A Y1 - 2007/08/26/ PY - 2007 DA - 2007 Aug 26 KW - Breast cancer KW - Developing countries KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39357834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=42nd+World+Congress+of+Surgery+of+the+International+Society+of+Surgery+ISS%2FSIC+%28International+Surgical+Week%29+%28ISW+2007%29&rft.atitle=Breast+Cancer+in+Young+Women+%2835+Years+or+Younger%29%3A+Features+of+Disease+Presentation+in+a+Developing+Country&rft.au=Youssef%2C+O%3BHassan%2C+N%3BNouh%2C+A&rft.aulast=Youssef&rft.aufirst=O&rft.date=2007-08-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=42nd+World+Congress+of+Surgery+of+the+International+Society+of+Surgery+ISS%2FSIC+%28International+Surgical+Week%29+%28ISW+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isw2007.com/Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Auditory Perception in Landau-Kleffner Syndrome T2 - 2007 International Congress of Pediatrics (ICP 2007) AN - 39546989; 4700525 JF - 2007 International Congress of Pediatrics (ICP 2007) AU - Kaga, Makiko AU - Inagaki, Masumi AU - Suzuki, Seiko Y1 - 2007/08/25/ PY - 2007 DA - 2007 Aug 25 KW - Perception KW - Auditory perception KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39546989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Congress+of+Pediatrics+%28ICP+2007%29&rft.atitle=Auditory+Perception+in+Landau-Kleffner+Syndrome&rft.au=Kaga%2C+Makiko%3BInagaki%2C+Masumi%3BSuzuki%2C+Seiko&rft.aulast=Kaga&rft.aufirst=Makiko&rft.date=2007-08-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Congress+of+Pediatrics+%28ICP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icp2007.gr/final/total.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Insights in Neurogenesis and Neuroprotection in Parkinson's Disease T2 - 11th Congress of the European Federation of Neurological Societies (EFNS 2007) AN - 39543110; 4674144 JF - 11th Congress of the European Federation of Neurological Societies (EFNS 2007) AU - Isacson, Ole Y1 - 2007/08/25/ PY - 2007 DA - 2007 Aug 25 KW - Neurogenesis KW - Neuroprotection KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39543110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Biology+%26+Drug+Design&rft.atitle=Natural+Products+Active+in+Aberrant+c-Kit+Signaling&rft.au=Henrich%2C+Curtis+J%3BGoncharova%2C+Ekaterina+I%3BWilson%2C+Jennifer+A%3BGardella%2C+Roberta+S%3BJohnson%2C+Tanya+R%3BMcMahon%2C+James+B%3BTakada%2C+Kentaro%3BBokesch%2C+Heidi+R%3BGustafson%2C+Kirk+R&rft.aulast=Henrich&rft.aufirst=Curtis&rft.date=2007-05-01&rft.volume=69&rft.issue=5&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Chemical+Biology+%26+Drug+Design&rft.issn=17470277&rft_id=info:doi/10.1111%2Fj.1747-0285.2007.00508.x L2 - http://www.kenes.com/efns2007/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Modeling Tissue Morphogenesis and Cancer in 3D AN - 20333294; 7553019 AB - Three-dimensional (3D) in vitro models span the gap between two-dimensional cell cultures and whole-animal systems. By mimicking features of the in vivo environment and taking advantage of the same tools used to study cells in traditional cell culture, 3D models provide unique perspectives on the behavior of stem cells, developing tissues and organs, and tumors. These models may help to accelerate translational research in cancer biology and tissue engineering. JF - Cell AU - Yamada, K M AU - Cukierman, E AD - National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, kenneth.yamada@nih.gov Y1 - 2007/08/24/ PY - 2007 DA - 2007 Aug 24 SP - 601 EP - 610 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 130 IS - 4 SN - 0092-8674, 0092-8674 KW - Biotechnology and Bioengineering Abstracts KW - Mimicry KW - Translation KW - Stem cells KW - Morphogenesis KW - Cell culture KW - Tumors KW - Tissue engineering KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20333294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell&rft.atitle=Modeling+Tissue+Morphogenesis+and+Cancer+in+3D&rft.au=Yamada%2C+K+M%3BCukierman%2C+E&rft.aulast=Yamada&rft.aufirst=K&rft.date=2007-08-24&rft.volume=130&rft.issue=4&rft.spage=601&rft.isbn=&rft.btitle=&rft.title=Cell&rft.issn=00928674&rft_id=info:doi/10.1016%2Fj.cell.2007.08.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cell culture; Cancer; Translation; Tumors; Tissue engineering; Stem cells; Mimicry; Morphogenesis DO - http://dx.doi.org/10.1016/j.cell.2007.08.006 ER - TY - JOUR T1 - Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3 receptor ligands: potential substance abuse therapeutic agents. AN - 68167568; 17672446 AB - Dopamine D3 receptor antagonists and partial agonists have been shown to modulate drug-seeking effects induced by cocaine and other abused substances. Compound 6 [PG01037, (N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-trans-but-2-enyl)-4-pyridine-2-ylbenzamide)] and related analogues are currently being evaluated in animal models of drug addiction. In these studies, a discrepancy between in vitro binding affinity, in vivo occupancy, and behavioral potency has been observed. The purpose of this study was to examine (1) modifications of the 2-pyridylphenyl moiety of 6 and (2) hydroxyl, acetyl, and cyclopropyl substitutions on the butylamide linking chain systematically coupled with 2-fluorenylamide or 2-pyridylphenylamide and 2-methoxy- or 2,3-dichloro-substituted phenylpiperazines to measure the impact on binding affinity, D2/D3 selectivity, lipophilicity, and function. In general, these modifications were well tolerated at the human dopamine D3 (hD3) receptor (Ki = 1-5 nM) as measured in competition binding assays. Several analogues showed >100-fold selectivity for dopamine D3 over D2 and D4 receptors. In addition, while all the derivatives with an olefinic linker were antagonists, in quinpirole-stimulated mitogenesis at hD3 receptors, several of the hydroxybutyl-linked analogues (16, 17, 21) showed partial agonist activity. Finally, several structural modifications reduced lipophilicities while retaining the desired binding profile. JF - Journal of medicinal chemistry AU - Grundt, Peter AU - Prevatt, Katherine M AU - Cao, Jianjing AU - Taylor, Michelle AU - Floresca, Christina Z AU - Choi, Ji-Kyung AU - Jenkins, Bruce G AU - Luedtke, Robert R AU - Newman, Amy Hauck AD - Medicinal Chemistry Section, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA. Y1 - 2007/08/23/ PY - 2007 DA - 2007 Aug 23 SP - 4135 EP - 4146 VL - 50 IS - 17 SN - 0022-2623, 0022-2623 KW - Amides KW - 0 KW - Benzamides KW - Ligands KW - N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)but-2-enyl)-4-pyridine-2-ylbenzamide KW - Piperazines KW - Pyridines KW - Receptors, Dopamine D3 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Animals KW - Benzamides -- chemistry KW - Stereoisomerism KW - Pyridines -- chemistry KW - Benzamides -- pharmacokinetics KW - Humans KW - Pyridines -- pharmacokinetics KW - Brain -- metabolism KW - Radioligand Assay KW - Structure-Activity Relationship KW - Rats KW - Binding, Competitive KW - Mitosis -- drug effects KW - Cell Line KW - Receptors, Dopamine D3 -- agonists KW - Piperazines -- chemical synthesis KW - Piperazines -- chemistry KW - Amides -- pharmacology KW - Amides -- chemical synthesis KW - Receptors, Dopamine D3 -- antagonists & inhibitors KW - Substance-Related Disorders -- drug therapy KW - Piperazines -- pharmacology KW - Amides -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68167568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Heterocyclic+analogues+of+N-%284-%284-%282%2C3-dichlorophenyl%29piperazin-1-yl%29butyl%29arylcarboxamides+with+functionalized+linking+chains+as+novel+dopamine+D3+receptor+ligands%3A+potential+substance+abuse+therapeutic+agents.&rft.au=Grundt%2C+Peter%3BPrevatt%2C+Katherine+M%3BCao%2C+Jianjing%3BTaylor%2C+Michelle%3BFloresca%2C+Christina+Z%3BChoi%2C+Ji-Kyung%3BJenkins%2C+Bruce+G%3BLuedtke%2C+Robert+R%3BNewman%2C+Amy+Hauck&rft.aulast=Grundt&rft.aufirst=Peter&rft.date=2007-08-23&rft.volume=50&rft.issue=17&rft.spage=4135&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=00222623&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-29 N1 - Date created - 2007-08-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Synthesis, Biological Activity, and Crystal Structure of Potent Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase That Retain Activity against Mutant Forms of the Enzyme AN - 19766392; 7581070 AB - In an ongoing effort to develop novel and potent nonnucleoside HIV-1 reverse transcriptase (RT) inhibitors that are effective against the wild type (WT) virus and clinically observed mutants, 1,2-bis-substituted benzimidazoles were synthesized and tested. Optimization of the N1 and C2 positions of benzimidazole led to the development of -(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-methylbenzimidazole (1) (IC sub(50) = 0.2 mu M, EC sub(50) = 0.44 mu M, and TC sub(50) greater than or equal to 100 against WT). This paper describes how substitution on the benzimidazole ring profoundly affects activity. Substituents at the benzimidazole C4 dramatically enhanced potency, while at C5 or C6 substituents were generally detrimental or neutral to activity, respectively. A 7-methyl analogue did not inhibit HIV-1 RT. Determination of the crystal structure of 1 bound to RT provided the basis for accurate modeling of additional analogues, which were synthesized and tested. Several derivatives were nanomolar inhibitors of wild-type virus and were effective against clinically relevant HIV-1 mutants. JF - Journal of Medicinal Chemistry AU - Morningstar, M L AU - Roth, T AU - Farnsworth, D W AU - Smith, M K AU - Watson, K AU - Buckheit, RW Jr AU - Das, K AU - Zhang, W AU - Arnold, E AU - Julias, J G AU - Hughes, SH AU - Michejda, C J AD - Molecular Aspects of Drug Design Section and Retroviral Replication Laboratory, National Cancer Institute-Frederick, P.O. Box B, Frederick, Maryland 21702, USA Y1 - 2007/08/23/ PY - 2007 DA - 2007 Aug 23 SP - 4003 EP - 4015 VL - 50 IS - 17 SN - 0022-2623, 0022-2623 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Human immunodeficiency virus 1 KW - Crystal structure KW - RNA-directed DNA polymerase KW - Enzymes KW - Benzimidazole KW - V 22360:AIDS and HIV KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19766392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medicinal+Chemistry&rft.atitle=Synthesis%2C+Biological+Activity%2C+and+Crystal+Structure+of+Potent+Nonnucleoside+Inhibitors+of+HIV-1+Reverse+Transcriptase+That+Retain+Activity+against+Mutant+Forms+of+the+Enzyme&rft.au=Morningstar%2C+M+L%3BRoth%2C+T%3BFarnsworth%2C+D+W%3BSmith%2C+M+K%3BWatson%2C+K%3BBuckheit%2C+RW+Jr%3BDas%2C+K%3BZhang%2C+W%3BArnold%2C+E%3BJulias%2C+J+G%3BHughes%2C+SH%3BMichejda%2C+C+J&rft.aulast=Morningstar&rft.aufirst=M&rft.date=2007-08-23&rft.volume=50&rft.issue=17&rft.spage=4003&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medicinal+Chemistry&rft.issn=00222623&rft_id=info:doi/10.1021%2Fjm060103d LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Crystal structure; Enzymes; RNA-directed DNA polymerase; Benzimidazole; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1021/jm060103d ER - TY - CPAPER T1 - Fostering International Validation and Acceptance of New and Alternative Methods: ICCVAM and NICEATM Initiatives T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39722781; 4721579 DE: JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Stokes, William Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39722781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Fostering+International+Validation+and+Acceptance+of+New+and+Alternative+Methods%3A+ICCVAM+and+NICEATM+Initiatives&rft.au=Stokes%2C+William&rft.aulast=Stokes&rft.aufirst=William&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Application of the Flow Cytometric Cytotoxicity Assay for Monitoring Cancer Vaccine Trials T2 - 13th International Congress of Immunology (ICI 2007) AN - 39692567; 4702463 JF - 13th International Congress of Immunology (ICI 2007) AU - Malyguine, A AU - Zaritskaya, L AU - Shafer-Weaver, K AU - Strobl, S AU - Gregory, M AU - Baseler, M Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Cancer KW - Vaccines KW - Cytotoxicity KW - Flow cytometry KW - Cancer vaccines KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39692567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Application+of+the+Flow+Cytometric+Cytotoxicity+Assay+for+Monitoring+Cancer+Vaccine+Trials&rft.au=Malyguine%2C+A%3BZaritskaya%2C+L%3BShafer-Weaver%2C+K%3BStrobl%2C+S%3BGregory%2C+M%3BBaseler%2C+M&rft.aulast=Malyguine&rft.aufirst=A&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Alternatives for Ocular Toxicity Testing: ICCVAM and NICEATM Recent and Planned Initiatives T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39626955; 4721459 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Stokes, William Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Toxicity testing KW - Bioaccumulation KW - Pollution indicators KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39626955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Alternatives+for+Ocular+Toxicity+Testing%3A+ICCVAM+and+NICEATM+Recent+and+Planned+Initiatives&rft.au=Stokes%2C+William&rft.aulast=Stokes&rft.aufirst=William&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Comet Assay: An Overview T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39624425; 4721511 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Tice, Raymond R Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Reviews KW - Comet assay KW - Toxicity testing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39624425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=The+Comet+Assay%3A+An+Overview&rft.au=Tice%2C+Raymond+R&rft.aulast=Tice&rft.aufirst=Raymond&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Topical Anesthetic Pre-treatment in the Draize Eye Test: Impact on Hazard Classification T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39605356; 4721648 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Stokes, William Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Eye KW - Classification KW - Anesthetics KW - Hazards KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39605356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Topical+Anesthetic+Pre-treatment+in+the+Draize+Eye+Test%3A+Impact+on+Hazard+Classification&rft.au=Stokes%2C+William&rft.aulast=Stokes&rft.aufirst=William&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Standardization of Protocols for the Validation of an In Vitro Estrogen Receptor Transcriptional Activation Assay T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39604754; 4721860 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Tice, Raymond Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Standardization KW - Estrogen receptors KW - Transcription activation KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39604754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Standardization+of+Protocols+for+the+Validation+of+an+In+Vitro+Estrogen+Receptor+Transcriptional+Activation+Assay&rft.au=Tice%2C+Raymond&rft.aulast=Tice&rft.aufirst=Raymond&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of B Cell Motility in Lymph Nodes T2 - 13th International Congress of Immunology (ICI 2007) AN - 39601280; 4701437 JF - 13th International Congress of Immunology (ICI 2007) AU - Kehrl, J H AU - Hwang, I AU - Park, C Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Lymph nodes KW - Lymphocytes B KW - Cell migration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39601280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Regulation+of+B+Cell+Motility+in+Lymph+Nodes&rft.au=Kehrl%2C+J+H%3BHwang%2C+I%3BPark%2C+C&rft.aulast=Kehrl&rft.aufirst=J&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vitro Cytotoxicity Test Methods for Estimating Rat Acute Oral Toxicity: Prediction of GHS Acute Oral Toxicity Categories T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39593849; 4721759 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Stokes, William Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Acute toxicity KW - Cytotoxicity KW - Toxicity testing KW - Bioaccumulation KW - Pollution indicators KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39593849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=In+Vitro+Cytotoxicity+Test+Methods+for+Estimating+Rat+Acute+Oral+Toxicity%3A+Prediction+of+GHS+Acute+Oral+Toxicity+Categories&rft.au=Stokes%2C+William&rft.aulast=Stokes&rft.aufirst=William&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Alternatives for Acute Oral Systemic Toxicity Testing: NICEATM/ICCVAM Current and Planned Activities T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39593454; 4721455 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Tice, Raymond Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Acute toxicity KW - Toxicity testing KW - Bioaccumulation KW - Pollution indicators KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39593454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Alternatives+for+Acute+Oral+Systemic+Toxicity+Testing%3A+NICEATM%2FICCVAM+Current+and+Planned+Activities&rft.au=Tice%2C+Raymond&rft.aulast=Tice&rft.aufirst=Raymond&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reducing Animal Use for Acute Oral Toxicity Testing: ICCVAM Recommendations for the Use of In Vitro Cytotoxicity Test Methods T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39584018; 4721691 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Stokes, William S Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Cytotoxicity KW - Acute toxicity KW - Toxicity testing KW - Bioaccumulation KW - Pollution indicators KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39584018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Reducing+Animal+Use+for+Acute+Oral+Toxicity+Testing%3A+ICCVAM+Recommendations+for+the+Use+of+In+Vitro+Cytotoxicity+Test+Methods&rft.au=Stokes%2C+William+S&rft.aulast=Stokes&rft.aufirst=William&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationship between Adverse Ocular Effects and their Reversibility T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39580666; 4721774 DE: JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Tice, Raymond Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39580666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Relationship+between+Adverse+Ocular+Effects+and+their+Reversibility&rft.au=Tice%2C+Raymond&rft.aulast=Tice&rft.aufirst=Raymond&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The NICEATM/ECVAM Validation Study of In Vitro Cytotoxicity Test Methods for Estimating Rat Acute Oral Toxicity T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39577955; 4721457 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Stokes, William Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Cytotoxicity KW - Acute toxicity KW - Toxicity testing KW - Bioaccumulation KW - Pollution indicators KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39577955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=The+NICEATM%2FECVAM+Validation+Study+of+In+Vitro+Cytotoxicity+Test+Methods+for+Estimating+Rat+Acute+Oral+Toxicity&rft.au=Stokes%2C+William&rft.aulast=Stokes&rft.aufirst=William&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Live Microfilariae of Brugia malayi Downregulate the Gene Expression and Function of TLR3 and TLR4 in Human DC Resulting in Inactivation of NFkB and Diminution of Inflammatory Cytokines T2 - 13th International Congress of Immunology (ICI 2007) AN - 39576256; 4701272 JF - 13th International Congress of Immunology (ICI 2007) AU - Semnani, R Tolouei AU - Goel, P AU - Leifer, C A AU - Mostbock, S AU - Sabzevari, H AU - Nutman, T B Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Inactivation KW - Toll-like receptors KW - TLR3 protein KW - Gene expression KW - TLR4 protein KW - Cytokines KW - NF-B protein KW - Inflammation KW - Brugia malayi KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39576256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Live+Microfilariae+of+Brugia+malayi+Downregulate+the+Gene+Expression+and+Function+of+TLR3+and+TLR4+in+Human+DC+Resulting+in+Inactivation+of+NFkB+and+Diminution+of+Inflammatory+Cytokines&rft.au=Semnani%2C+R+Tolouei%3BGoel%2C+P%3BLeifer%2C+C+A%3BMostbock%2C+S%3BSabzevari%2C+H%3BNutman%2C+T+B&rft.aulast=Semnani&rft.aufirst=R&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of c-Myc Expression by NFAT1 Transcription Factor in Lymphocytes T2 - 13th International Congress of Immunology (ICI 2007) AN - 39561905; 4702516 JF - 13th International Congress of Immunology (ICI 2007) AU - Mognol, G P AU - Caetano, M S AU - Robbs, B K AU - Viola, J P B Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Lymphocytes KW - C-Myc protein KW - Transcription factors KW - NF-AT1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39561905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Regulation+of+c-Myc+Expression+by+NFAT1+Transcription+Factor+in+Lymphocytes&rft.au=Mognol%2C+G+P%3BCaetano%2C+M+S%3BRobbs%2C+B+K%3BViola%2C+J+P+B&rft.aulast=Mognol&rft.aufirst=G&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Quality of the Th1 Response Following Vaccination Correlates with Protection Against Leishmania Major Infection T2 - 13th International Congress of Immunology (ICI 2007) AN - 39558110; 4701115 JF - 13th International Congress of Immunology (ICI 2007) AU - Darrah, P A AU - Patel, D T AU - De Luca, P M AU - Lindsay, R W B AU - Davey, D F AU - Roederer, M AU - Seder, R A Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Infection KW - Vaccination KW - Lymphocytes T KW - Helper cells KW - Leishmania major KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39558110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=The+Quality+of+the+Th1+Response+Following+Vaccination+Correlates+with+Protection+Against+Leishmania+Major+Infection&rft.au=Darrah%2C+P+A%3BPatel%2C+D+T%3BDe+Luca%2C+P+M%3BLindsay%2C+R+W+B%3BDavey%2C+D+F%3BRoederer%2C+M%3BSeder%2C+R+A&rft.aulast=Darrah&rft.aufirst=P&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel TTF-1 Mutation with Mild IgA Deficiency T2 - 13th International Congress of Immunology (ICI 2007) AN - 39556897; 4702517 JF - 13th International Congress of Immunology (ICI 2007) AU - Elloumi, H AU - Uzel, G AU - Ding, L AU - Anderson, V AU - Holland, S M Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Mutation KW - Immunoglobulin A KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39556897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Novel+TTF-1+Mutation+with+Mild+IgA+Deficiency&rft.au=Elloumi%2C+H%3BUzel%2C+G%3BDing%2C+L%3BAnderson%2C+V%3BHolland%2C+S+M&rft.aulast=Elloumi&rft.aufirst=H&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Estrogen Receptor Mechanisms: How They Influence Environmental Factor Activities T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39550633; 4721507 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Korach, Kenneth S Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Environmental factors KW - Estrogen receptors KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39550633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Estrogen+Receptor+Mechanisms%3A+How+They+Influence+Environmental+Factor+Activities&rft.au=Korach%2C+Kenneth+S&rft.aulast=Korach&rft.aufirst=Kenneth&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distinct Roles of Two Types of NKT Cells in the Regulation of Tumor Imunity T2 - 13th International Congress of Immunology (ICI 2007) AN - 39547395; 4702078 JF - 13th International Congress of Immunology (ICI 2007) AU - Terabe, M AU - Ambrosino, E AU - Takaku, S AU - Peng, J AU - Miyake, S AU - Halder, R C AU - Yamamura, T AU - Kumar, V AU - Berzofsky, J A Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Tumors KW - Lymphocytes T KW - Natural killer cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39547395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Distinct+Roles+of+Two+Types+of+NKT+Cells+in+the+Regulation+of+Tumor+Imunity&rft.au=Terabe%2C+M%3BAmbrosino%2C+E%3BTakaku%2C+S%3BPeng%2C+J%3BMiyake%2C+S%3BHalder%2C+R+C%3BYamamura%2C+T%3BKumar%2C+V%3BBerzofsky%2C+J+A&rft.aulast=Terabe&rft.aufirst=M&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NK Cells are Required for Optimal IL-12 Production by CD11b+CD8- Dendritic Cells and Host Resistance to Toxoplasma Gondii. T2 - 13th International Congress of Immunology (ICI 2007) AN - 39541277; 4701078 JF - 13th International Congress of Immunology (ICI 2007) AU - Goldszmid, R AU - Feng, C AU - Rothfuchs, A AU - Jankovic, D AU - Caspar, P AU - Reinhardt, L AU - Locksley, R AU - Sher, A Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - CD11b antigen KW - Dendritic cells KW - Interleukin 12 KW - Natural killer cells KW - Toxoplasma gondii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39541277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=NK+Cells+are+Required+for+Optimal+IL-12+Production+by+CD11b%2BCD8-+Dendritic+Cells+and+Host+Resistance+to+Toxoplasma+Gondii.&rft.au=Goldszmid%2C+R%3BFeng%2C+C%3BRothfuchs%2C+A%3BJankovic%2C+D%3BCaspar%2C+P%3BReinhardt%2C+L%3BLocksley%2C+R%3BSher%2C+A&rft.aulast=Goldszmid&rft.aufirst=R&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Redesigned NICEATM-ICCVAM Website: Improving Communication with Stakeholders T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39533166; 4721689 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Tice, Raymond Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Stakeholders KW - Communication KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39533166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=The+Redesigned+NICEATM-ICCVAM+Website%3A+Improving+Communication+with+Stakeholders&rft.au=Tice%2C+Raymond&rft.aulast=Tice&rft.aufirst=Raymond&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NICEATM/ECVAM/JaCVAM Multi-phased International Validation Study of an In Vitro Estrogen Receptor Transcriptional Activation Assay to Detect Agonist and Antagonist Activity T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39531097; 4721861 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Stokes, William S Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Estrogen receptors KW - Transcription activation KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39531097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=NICEATM%2FECVAM%2FJaCVAM+Multi-phased+International+Validation+Study+of+an+In+Vitro+Estrogen+Receptor+Transcriptional+Activation+Assay+to+Detect+Agonist+and+Antagonist+Activity&rft.au=Stokes%2C+William+S&rft.aulast=Stokes&rft.aufirst=William&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of the Defective Interaction between a Subset of Natural Killer Cells and Dendritic Cells in HIV-1 Infection T2 - 13th International Congress of Immunology (ICI 2007) AN - 39530680; 4701059 JF - 13th International Congress of Immunology (ICI 2007) AU - Mavilio, D AU - Lombardo, G AU - Fogli, M AU - Kinter, A AU - La Sala, A AU - Follmann, D AU - Roby, G AU - Kovacs, C AU - Marcenaro, E AU - Pende, D AU - Moretta, A AU - Fauci, A S Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Infection KW - Dendritic cells KW - Natural killer cells KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39530680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Characterization+of+the+Defective+Interaction+between+a+Subset+of+Natural+Killer+Cells+and+Dendritic+Cells+in+HIV-1+Infection&rft.au=Mavilio%2C+D%3BLombardo%2C+G%3BFogli%2C+M%3BKinter%2C+A%3BLa+Sala%2C+A%3BFollmann%2C+D%3BRoby%2C+G%3BKovacs%2C+C%3BMarcenaro%2C+E%3BPende%2C+D%3BMoretta%2C+A%3BFauci%2C+A+S&rft.aulast=Mavilio&rft.aufirst=D&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CYBB, a NADPH-oxidase Coding Gene: Restricted Diversity in Humans and Evidence for Differential Long Term Purifying Selection on Trans-membrane and Cytosolic Domains T2 - 13th International Congress of Immunology (ICI 2007) AN - 39526793; 4701303 JF - 13th International Congress of Immunology (ICI 2007) AU - Tarazona-Santos, E M AU - Bernig, T AU - Burdett, L AU - Fabbri, C AU - Magalhaes, W AU - Redondo, R AU - Welch, R AU - Yeager, M AU - Chanock, S J Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - NADPH oxidase KW - Genetic diversity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39526793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=CYBB%2C+a+NADPH-oxidase+Coding+Gene%3A+Restricted+Diversity+in+Humans+and+Evidence+for+Differential+Long+Term+Purifying+Selection+on+Trans-membrane+and+Cytosolic+Domains&rft.au=Tarazona-Santos%2C+E+M%3BBernig%2C+T%3BBurdett%2C+L%3BFabbri%2C+C%3BMagalhaes%2C+W%3BRedondo%2C+R%3BWelch%2C+R%3BYeager%2C+M%3BChanock%2C+S+J&rft.aulast=Tarazona-Santos&rft.aufirst=E&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Gene Expression Profile between M. abscessus and M. avium: Possible Role of SOCS Proteins in Mediating the Extent of Innate Immune Response T2 - 13th International Congress of Immunology (ICI 2007) AN - 39523367; 4701167 JF - 13th International Congress of Immunology (ICI 2007) AU - Sampaio, E P Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Immune response KW - Gene expression KW - Immunity KW - Defense mechanisms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39523367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Differential+Gene+Expression+Profile+between+M.+abscessus+and+M.+avium%3A+Possible+Role+of+SOCS+Proteins+in+Mediating+the+Extent+of+Innate+Immune+Response&rft.au=Sampaio%2C+E+P&rft.aulast=Sampaio&rft.aufirst=E&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Histone Acetylation is Associated with Differential Gene Expression in the Rapid and Robust Memory CD8+ T Cell Response T2 - 13th International Congress of Immunology (ICI 2007) AN - 39522580; 4701266 JF - 13th International Congress of Immunology (ICI 2007) AU - Fann, M AU - Weng, N P Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Gene expression KW - Memory cells KW - Histones KW - CD8 antigen KW - Lymphocytes T KW - Immunological memory KW - Acetylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39522580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Histone+Acetylation+is+Associated+with+Differential+Gene+Expression+in+the+Rapid+and+Robust+Memory+CD8%2B+T+Cell+Response&rft.au=Fann%2C+M%3BWeng%2C+N+P&rft.aulast=Fann&rft.aufirst=M&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulatory Elements Governing Transcription of the Human DAP10 Gene T2 - 13th International Congress of Immunology (ICI 2007) AN - 39494426; 4700945 JF - 13th International Congress of Immunology (ICI 2007) AU - Coligan, J E AU - Marusina, A AU - Burgess, S J AU - Borrego, F Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Regulatory sequences KW - Transcription KW - DAP10 gene KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39494426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Regulatory+Elements+Governing+Transcription+of+the+Human+DAP10+Gene&rft.au=Coligan%2C+J+E%3BMarusina%2C+A%3BBurgess%2C+S+J%3BBorrego%2C+F&rft.aulast=Coligan&rft.aufirst=J&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Abrogation of Potent Humoral Vaccine Responses in Patients on Long-term Anti-CD25 Therapy T2 - 13th International Congress of Immunology (ICI 2007) AN - 39490339; 4701109 JF - 13th International Congress of Immunology (ICI 2007) AU - Ragheb, J A AU - Buggage, R AU - Reed, G AU - Levy-Clarke, G AU - Nussenblatt, R Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Vaccines KW - Therapy KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39490339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Abrogation+of+Potent+Humoral+Vaccine+Responses+in+Patients+on+Long-term+Anti-CD25+Therapy&rft.au=Ragheb%2C+J+A%3BBuggage%2C+R%3BReed%2C+G%3BLevy-Clarke%2C+G%3BNussenblatt%2C+R&rft.aulast=Ragheb&rft.aufirst=J&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Small Intestinal Lamina Propria Dendritic Cells Favor the Conversion of Foxp3 super(+) T sub(reg) T2 - 13th International Congress of Immunology (ICI 2007) AN - 39490046; 4701024 JF - 13th International Congress of Immunology (ICI 2007) AU - Sun, C AU - Hall, J AU - Blank, R AU - Belkaid, Y Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Intestine KW - Dendritic cells KW - Lymphocytes T KW - Lamina propria KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39490046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Small+Intestinal+Lamina+Propria+Dendritic+Cells+Favor+the+Conversion+of+Foxp3+super%28%2B%29+T+sub%28reg%29&rft.au=Sun%2C+C%3BHall%2C+J%3BBlank%2C+R%3BBelkaid%2C+Y&rft.aulast=Sun&rft.aufirst=C&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dual Role for NFAT Transcription Factors in Cell Proliferation and Transformation T2 - 13th International Congress of Immunology (ICI 2007) AN - 39452860; 4701125 JF - 13th International Congress of Immunology (ICI 2007) AU - Robbs, B K AU - Cruz, A L S AU - Mognol, G P AU - Viola, J P B Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Cell proliferation KW - Transcription factors KW - Transformation KW - NF-AT protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39452860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Dual+Role+for+NFAT+Transcription+Factors+in+Cell+Proliferation+and+Transformation&rft.au=Robbs%2C+B+K%3BCruz%2C+A+L+S%3BMognol%2C+G+P%3BViola%2C+J+P+B&rft.aulast=Robbs&rft.aufirst=B&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Filarial Parasites Induce NK Cell Activation, NK1 (IFNg and TNFa) and NK2 (IL-4 and IL-5) Differentiation and Subsequent Apoptotic Cell Death T2 - 13th International Congress of Immunology (ICI 2007) AN - 39452206; 4700965 JF - 13th International Congress of Immunology (ICI 2007) AU - Babu, S Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Parasites KW - Mortality KW - Tumor necrosis factor-a KW - Interleukin 5 KW - Cell death KW - Interleukin 4 KW - Differentiation KW - Natural killer cells KW - Cell activation KW - Apoptosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39452206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Filarial+Parasites+Induce+NK+Cell+Activation%2C+NK1+%28IFNg+and+TNFa%29+and+NK2+%28IL-4+and+IL-5%29+Differentiation+and+Subsequent+Apoptotic+Cell+Death&rft.au=Babu%2C+S&rft.aulast=Babu&rft.aufirst=S&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Structural and Biochemical Analyses of Shikimate Dehydrogenase AroE from Aquifex aeolicus: Implications for the Catalytic Mechanism AN - 20460952; 7728741 AB - The shikimate biosynthetic pathway is essential to microorganisms, plants, and parasites but absent from mammals. Therefore, shikimate dehydrogenase (SD) and other enzymes in the pathway are attractive targets for developing nontoxic antimicrobial agents, herbicides, and antiparasite drugs. SD catalyzes the fourth reaction in the pathway, the nicotinamide adenine dinucleotide phosphate- (NADP-) dependent reduction of 3-dehydroshikimic acid to shikimic acid (SA), as well as its reverse, by the transfer of a hydride. Previous structural studies reveal that the enzyme exists in two major conformations, an open and a closed form. For the reaction to occur, it is believed that the catalytic complex assumes the closed conformation. Nonetheless, the only structure containing both SA and NADP super(+) exhibits an open conformation (PDB entry 2EV9). Here, we present two crystal structures of Aquifex aeolicus SD, including a ternary complex with both SA and NADP super(+), which assumes the closed conformation and therefore contains a catalytically competent active site. On the basis of preexisting and novel structural and biochemical data, a catalytic mechanism is proposed. JF - Biochemistry (Washington) AU - Gan, J AU - Wu, Y AU - Prabakaran, P AU - Gu, Y AU - Li, Y AU - Andrykovitch, M AU - Liu, H AU - Gong, Y AU - Yan, H AU - Ji, X AD - Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 SP - 9513 EP - 9522 VL - 46 IS - 33 SN - 0006-2960, 0006-2960 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology KW - Parasites KW - shikimic acid KW - Data processing KW - Enzymes KW - Biochemical analysis KW - Animal physiology KW - Herbicides KW - Antimicrobial agents KW - Shikimate dehydrogenase KW - Aquifex aeolicus KW - Crystal structure KW - Microorganisms KW - Drugs KW - Dehydrogenases KW - Conformation KW - A 01340:Antibiotics & Antimicrobials KW - Q1 08246:Physiology, biochemistry, biophysics KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20460952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Structural+and+Biochemical+Analyses+of+Shikimate+Dehydrogenase+AroE+from+Aquifex+aeolicus%3A+Implications+for+the+Catalytic+Mechanism&rft.au=Gan%2C+J%3BWu%2C+Y%3BPrabakaran%2C+P%3BGu%2C+Y%3BLi%2C+Y%3BAndrykovitch%2C+M%3BLiu%2C+H%3BGong%2C+Y%3BYan%2C+H%3BJi%2C+X&rft.aulast=Gan&rft.aufirst=J&rft.date=2007-08-21&rft.volume=46&rft.issue=33&rft.spage=9513&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi602601e LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Microorganisms; Biochemical analysis; Herbicides; Animal physiology; Dehydrogenases; Shikimate dehydrogenase; Parasites; Data processing; shikimic acid; Crystal structure; Enzymes; Drugs; Antimicrobial agents; Conformation; Aquifex aeolicus DO - http://dx.doi.org/10.1021/bi602601e ER - TY - JOUR T1 - Inactivation of cytosolic aldehyde dehydrogenase via S-nitrosylation in ethanol-exposed rat liver AN - 19466331; 7552783 AB - Aldehyde dehydrogenase (ALDH) isozymes are critically important in the metabolism of acetaldehyde, thus preventing its accumulation after ethanol-exposure. We previously reported that mitochondrial ALDH2 could be inactivated via S-nitrosylation in ethanol-exposed rats. This study was aimed at investigating whether cytosolic ALDH1, with a relatively-low-K sub(m) value (11-18 mu M) for acetaldehyde, could be also inhibited in ethanol-exposed rats. Chronic or binge ethanol-exposure significantly decreased ALDH1 activity, which was restored by addition of dithiothreitol. Immunoblot analysis with the anti-S-nitroso-Cys antibody showed one immunoreactive band in the immunoprecipitated ALDH1 only from ethanol-exposed rats, but not from pair-fed controls, suggesting S-nitrosylation of ALDH1. Therefore inactivation of ALDH1 via S-nitrosylation can result in accumulation of acetaldehyde upon ethanol-exposure. JF - FEBS Letters AU - Moon, KH AU - Abdelmegeed, MA AU - Song, B J AD - National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 9000 Rockville pike, Bethesda, MD 20892-9410, USA, bjs@mail.nih.gov Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 SP - 3967 EP - 3972 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 581 IS - 21 SN - 0014-5793, 0014-5793 KW - Toxicology Abstracts KW - Antibodies KW - Acetaldehyde KW - Isoenzymes KW - Liver KW - Mitochondria KW - Dithiothreitol KW - Aldehyde dehydrogenase KW - Metabolism KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19466331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=Inactivation+of+cytosolic+aldehyde+dehydrogenase+via+S-nitrosylation+in+ethanol-exposed+rat+liver&rft.au=Moon%2C+KH%3BAbdelmegeed%2C+MA%3BSong%2C+B+J&rft.aulast=Moon&rft.aufirst=KH&rft.date=2007-08-21&rft.volume=581&rft.issue=21&rft.spage=3967&rft.isbn=&rft.btitle=&rft.title=FEBS+Letters&rft.issn=00145793&rft_id=info:doi/10.1016%2Fj.febslet.2007.07.037 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Antibodies; Acetaldehyde; Liver; Isoenzymes; Mitochondria; Dithiothreitol; Aldehyde dehydrogenase; Metabolism DO - http://dx.doi.org/10.1016/j.febslet.2007.07.037 ER - TY - JOUR T1 - A turning point for conflicts of interest: the controversy over the National Academy of Sciences' first conflicts of interest disclosure policy. AN - 68180581; 17704427 AB - Conflicts of interest policies have become a part of the fabric of the conduct of biomedical research, yet such concerns are relatively recent history. Until the 1960s, concerns about conflicts of interest were confined to scientists who served as government advisors and contractors. However, in the 1970s, as a range of environmental and consumer safety issues gained public attention, the conclusions of researchers frequently came under attack because of concerns about experts' financial ties to private industry. These debates typically focused on evaluating potential carcinogens in the environment. In response, the National Academy of Sciences (NAS) developed its first conflict of interest policy, requiring committee members to disclose any "potential sources of bias" that "others might deem prejudicial." Scientists universally opposed the policy, however, for a range of reasons--while some argued that all experienced and knowledgeable experts were inherently conflicted, others were offended at the suggestion that any expert could be biased. Despite the controversy, the disclosure policy remained in place and became a model for subsequent professional and institutional policies in the biomedical sciences. However, although disclosure policies have become standard at academic medical centers and for publications in scientific journals, clinical researchers have continued to debate the content of these policies and the need for additional protections beyond disclosure. In the absence of a definitive standard, this historical case study can substantially inform ongoing discussion on conflicts of interest in clinical research. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Parascandola, Mark AD - Tobacco Control Research Branch, National Cancer Institute, Bethesda, MD 20892, USA. paramark@mail.nih.gov Y1 - 2007/08/20/ PY - 2007 DA - 2007 Aug 20 SP - 3774 EP - 3779 VL - 25 IS - 24 KW - Index Medicus KW - United States KW - Financing, Government KW - Research Support as Topic KW - Industry KW - Biomedical Research KW - Organizational Policy KW - Conflict of Interest KW - National Academy of Sciences (U.S.) KW - Disclosure -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68180581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=A+turning+point+for+conflicts+of+interest%3A+the+controversy+over+the+National+Academy+of+Sciences%27+first+conflicts+of+interest+disclosure+policy.&rft.au=Parascandola%2C+Mark&rft.aulast=Parascandola&rft.aufirst=Mark&rft.date=2007-08-20&rft.volume=25&rft.issue=24&rft.spage=3774&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-12 N1 - Date created - 2007-08-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Synthesis of a Reactive Linker for the Construction of Antibody-Drug Hybrid Molecules T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39461707; 4637892 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Thomas, Joshua D AU - Hofer, Thomas AU - Rader, Christoph AU - Burke Jr, Terrence R Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Hybrids KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39461707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Synthesis+of+a+Reactive+Linker+for+the+Construction+of+Antibody-Drug+Hybrid+Molecules&rft.au=Thomas%2C+Joshua+D%3BHofer%2C+Thomas%3BRader%2C+Christoph%3BBurke+Jr%2C+Terrence+R&rft.aulast=Thomas&rft.aufirst=Joshua&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Medicinal Chemistry in Drug Abuse Research T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39457210; 4637989 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Rice, Kenner C Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Drug abuse KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39457210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Medicinal+Chemistry+in+Drug+Abuse+Research&rft.au=Rice%2C+Kenner+C&rft.aulast=Rice&rft.aufirst=Kenner&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Design and Synthesis of C-Met Kinase Inhibitors Based on an in Silico Screen-Derived Lead T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39454490; 4638130 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Kim, Sung-Eun AU - Shi, Zhen-Dan AU - Peach, Megan AU - Giubellino, Alessio AU - Nicklaus, Marc C AU - Bottaro, Donald AU - Burke Jr, Terrence R Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Lead KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39454490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Design+and+Synthesis+of+C-Met+Kinase+Inhibitors+Based+on+an+in+Silico+Screen-Derived+Lead&rft.au=Kim%2C+Sung-Eun%3BShi%2C+Zhen-Dan%3BPeach%2C+Megan%3BGiubellino%2C+Alessio%3BNicklaus%2C+Marc+C%3BBottaro%2C+Donald%3BBurke+Jr%2C+Terrence+R&rft.aulast=Kim&rft.aufirst=Sung-Eun&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single Molecule FRET Efficiency Distributions of Diffusing Molecules with Conformational Dynamics T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39453040; 4631516 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Szabo, Attila AU - Gopich, Irina Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Fluorescence resonance energy transfer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39453040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Single+Molecule+FRET+Efficiency+Distributions+of+Diffusing+Molecules+with+Conformational+Dynamics&rft.au=Szabo%2C+Attila%3BGopich%2C+Irina&rft.aulast=Szabo&rft.aufirst=Attila&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Large Ion Channels: Role of Interactions with Penetrating Molecules T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39452615; 4631412 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Bezrukov, Sergey M Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Channels KW - Ion channels KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39452615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Large+Ion+Channels%3A+Role+of+Interactions+with+Penetrating+Molecules&rft.au=Bezrukov%2C+Sergey+M&rft.aulast=Bezrukov&rft.aufirst=Sergey&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Coarse Master Equations for Peptide Folding Kinetics from Atomistic Molecular Simulations T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39446711; 4630534 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Buchete, Nicolae-Viorel AU - Hummer, Gerhard Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Kinetics KW - Simulation KW - Mathematical models KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39446711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Coarse+Master+Equations+for+Peptide+Folding+Kinetics+from+Atomistic+Molecular+Simulations&rft.au=Buchete%2C+Nicolae-Viorel%3BHummer%2C+Gerhard&rft.aulast=Buchete&rft.aufirst=Nicolae-Viorel&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PCDD/Fs Formation onto the Fly Ash Matrix from Metal-Mediated Catalysts T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39446656; 4637686 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Lin, Chieh AU - Wang, Ya-Hsin Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Catalysts KW - Fly ash KW - PCDD KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39446656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=PCDD%2FFs+Formation+onto+the+Fly+Ash+Matrix+from+Metal-Mediated+Catalysts&rft.au=Lin%2C+Chieh%3BWang%2C+Ya-Hsin&rft.aulast=Lin&rft.aufirst=Chieh&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - D-Galactose Receptor-Targeted In Vivo Spectral Fluorescence Molecular Imaging of Peritoneal Metastasis T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39446627; 4637299 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Kobayashi, Hisataka AU - Hama, Yukihiro AU - Gunn, Andrew J AU - Koyama, Yoshinori AU - Urano, Yasuteru AU - Choyke, Peter L Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Fluorescence KW - Imaging techniques KW - Peritoneum KW - D-Galactose KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39446627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=D-Galactose+Receptor-Targeted+In+Vivo+Spectral+Fluorescence+Molecular+Imaging+of+Peritoneal+Metastasis&rft.au=Kobayashi%2C+Hisataka%3BHama%2C+Yukihiro%3BGunn%2C+Andrew+J%3BKoyama%2C+Yoshinori%3BUrano%2C+Yasuteru%3BChoyke%2C+Peter+L&rft.aulast=Kobayashi&rft.aufirst=Hisataka&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hidden Folding Intermediates in Small Proteins: Implications for the Folding Energy Landscape, Cooperativity, and Evolution of Protein Structures T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39446012; 4637166 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Bai, Yawen Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Energy KW - Protein structure KW - Evolution KW - Cooperativity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39446012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Hidden+Folding+Intermediates+in+Small+Proteins%3A+Implications+for+the+Folding+Energy+Landscape%2C+Cooperativity%2C+and+Evolution+of+Protein+Structures&rft.au=Bai%2C+Yawen&rft.aulast=Bai&rft.aufirst=Yawen&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synthesis of DAG-Lactones Containing Heterocyclic Moieties: Small Focused Libraries in Search of C1-Specific Domain Interactions T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39443404; 4638163 DE: JF - 234th National Meeting and Exposition of the American Chemical Society AU - El Kazzouli, Said AU - Lewin, Nancy E AU - Blumberg, Peter M AU - Marquez, Vicror E Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39443404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Synthesis+of+DAG-Lactones+Containing+Heterocyclic+Moieties%3A+Small+Focused+Libraries+in+Search+of+C1-Specific+Domain+Interactions&rft.au=El+Kazzouli%2C+Said%3BLewin%2C+Nancy+E%3BBlumberg%2C+Peter+M%3BMarquez%2C+Vicror+E&rft.aulast=El+Kazzouli&rft.aufirst=Said&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nitric Oxide-Induced Deamidation Retards and Reverses Fibril Formation by an Oligo(Glutamine/Asparagine) Peptide T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39438862; 4635270 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Kong, Li AU - Saavedra, Joseph E AU - Nagashima, kunio AU - Zheng, Jiwen AU - Patri, Anil AU - Keefer, Larry K Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Fibrillogenesis KW - Asparagine KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39438862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Nitric+Oxide-Induced+Deamidation+Retards+and+Reverses+Fibril+Formation+by+an+Oligo%28Glutamine%2FAsparagine%29+Peptide&rft.au=Kong%2C+Li%3BSaavedra%2C+Joseph+E%3BNagashima%2C+kunio%3BZheng%2C+Jiwen%3BPatri%2C+Anil%3BKeefer%2C+Larry+K&rft.aulast=Kong&rft.aufirst=Li&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Address Book for Chemical Space: The Chemical Structure Lookup Service (CSLS) T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39438359; 4630013 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Sitzmann, Markus AU - Filippov, Igor V AU - Ihlenfeldt, Wolf-Dietrich AU - Nicklaus, Marc C Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Books KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39438359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=An+Address+Book+for+Chemical+Space%3A+The+Chemical+Structure+Lookup+Service+%28CSLS%29&rft.au=Sitzmann%2C+Markus%3BFilippov%2C+Igor+V%3BIhlenfeldt%2C+Wolf-Dietrich%3BNicklaus%2C+Marc+C&rft.aulast=Sitzmann&rft.aufirst=Markus&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Carbocyclic Analogs of 1,3-Diazepin-2-One Nucleosides as Transition-State Inhibitors of Cytidine Deaminase T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39437100; 4634107 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Marquez, Victor E AU - Ludek, Olaf R Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Nucleoside analogs KW - Cytidine deaminase KW - Analogs KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39437100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Carbocyclic+Analogs+of+1%2C3-Diazepin-2-One+Nucleosides+as+Transition-State+Inhibitors+of+Cytidine+Deaminase&rft.au=Marquez%2C+Victor+E%3BLudek%2C+Olaf+R&rft.aulast=Marquez&rft.aufirst=Victor&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biomechanical Properties of Tissue Engineered Cartilage T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39435940; 4637521 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Horkay, Ferenc AU - Lin, David C AU - Horkayne-Szakaly, Iren AU - Dimitriadis, Emilios K AU - Silva, Candida AU - Basser, Peter J Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Biomechanics KW - Mechanical properties KW - Cartilage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39435940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Biomechanical+Properties+of+Tissue+Engineered+Cartilage&rft.au=Horkay%2C+Ferenc%3BLin%2C+David+C%3BHorkayne-Szakaly%2C+Iren%3BDimitriadis%2C+Emilios+K%3BSilva%2C+Candida%3BBasser%2C+Peter+J&rft.aulast=Horkay&rft.aufirst=Ferenc&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Discovery of Novel HIV-1 Integrase Inhibitors by Pharmacophore Search T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39435454; 4637877 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Weidlich, Iwona E AU - Marchand, Christophe AU - Pommier, Yves AU - Nicklaus, Marc C Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Integrase KW - Pharmacophores KW - Inhibitors KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39435454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Discovery+of+Novel+HIV-1+Integrase+Inhibitors+by+Pharmacophore+Search&rft.au=Weidlich%2C+Iwona+E%3BMarchand%2C+Christophe%3BPommier%2C+Yves%3BNicklaus%2C+Marc+C&rft.aulast=Weidlich&rft.aufirst=Iwona&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Study of Conformationally Biased Oligodeoxyribonucleotides Designed to Induce Bending And/Or Novel Secondary Structures in DNA T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39435268; 4638112 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Saneyoshi, Hisao AU - Marquez, Victor E Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Oligonucleotides KW - Protein structure KW - Secondary structure KW - Deformation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39435268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Study+of+Conformationally+Biased+Oligodeoxyribonucleotides+Designed+to+Induce+Bending+And%2FOr+Novel+Secondary+Structures+in+DNA&rft.au=Saneyoshi%2C+Hisao%3BMarquez%2C+Victor+E&rft.aulast=Saneyoshi&rft.aufirst=Hisao&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Dynamics Simulations Suggest a Way to Stabilize Von Hippel-Lindau Tumor Suppressor Protein and Rescue its Function T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39433673; 4630386 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Liu, Jin AU - Nussinov, Ruth Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Simulation KW - VHL protein KW - Tumor suppressor genes KW - Tumors KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39433673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Molecular+Dynamics+Simulations+Suggest+a+Way+to+Stabilize+Von+Hippel-Lindau+Tumor+Suppressor+Protein+and+Rescue+its+Function&rft.au=Liu%2C+Jin%3BNussinov%2C+Ruth&rft.aulast=Liu&rft.aufirst=Jin&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamics of Intramolecular Contact Formation in Islet Amyloid Polypeptide (IAPP) T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39430770; 4637175 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Vaiana, Sara AU - Eaton, William A AU - Ghirlando, Rodolfo AU - Hofrichter, James Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Amylin KW - Polypeptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39430770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Dynamics+of+Intramolecular+Contact+Formation+in+Islet+Amyloid+Polypeptide+%28IAPP%29&rft.au=Vaiana%2C+Sara%3BEaton%2C+William+A%3BGhirlando%2C+Rodolfo%3BHofrichter%2C+James&rft.aulast=Vaiana&rft.aufirst=Sara&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exploring QM/MM Paths for Mapping Reaction Mechanisms T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39427275; 4630440 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Woodcock III, H Lee AU - Hodoscek, Milan AU - Brooks, Bernard R Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Mapping KW - Reaction mechanisms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39427275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Exploring+QM%2FMM+Paths+for+Mapping+Reaction+Mechanisms&rft.au=Woodcock+III%2C+H+Lee%3BHodoscek%2C+Milan%3BBrooks%2C+Bernard+R&rft.aulast=Woodcock+III&rft.aufirst=H&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ultrafast Folding of the Villin Subdomain T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39425629; 4637168 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Cellmer, Troy AU - Eaton, William A AU - Hofrichter, James Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Protein folding KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39425629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Ultrafast+Folding+of+the+Villin+Subdomain&rft.au=Cellmer%2C+Troy%3BEaton%2C+William+A%3BHofrichter%2C+James&rft.aulast=Cellmer&rft.aufirst=Troy&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mutant Glycosyltransferases Assist in Linking Glycoconjugates Via Glycan Chains: Development of a Targeted Drug Delivery System and Contrast Agents for MRI T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39421252; 4637296 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Qasba, Pradman Krishen AU - Boeggeman, Elizabeth AU - Ramakrishnan, Boopathy Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Drug delivery KW - Mutants KW - Magnetic resonance imaging KW - Glycoconjugates KW - Glycosyltransferase KW - Contrast media KW - Polysaccharides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39421252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Mutant+Glycosyltransferases+Assist+in+Linking+Glycoconjugates+Via+Glycan+Chains%3A+Development+of+a+Targeted+Drug+Delivery+System+and+Contrast+Agents+for+MRI&rft.au=Qasba%2C+Pradman+Krishen%3BBoeggeman%2C+Elizabeth%3BRamakrishnan%2C+Boopathy&rft.aulast=Qasba&rft.aufirst=Pradman&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analytical Ultracentrifugation for the Characterization of Proteins and Protein Assemblies T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39417949; 4638495 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Schuck, Peter Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Ultracentrifugation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39417949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Analytical+Ultracentrifugation+for+the+Characterization+of+Proteins+and+Protein+Assemblies&rft.au=Schuck%2C+Peter&rft.aulast=Schuck&rft.aufirst=Peter&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Utilizing a Diazirine and Alkyne Containing Probe in a Proof of Principle Study to Investigate Small Molecule Interactions Across the Proteome T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39417908; 4638206 JF - 234th National Meeting and Exposition of the American Chemical Society AU - LeClair, Christopher A AU - Prinz, William A AU - Raychaudhuri, Sumana AU - Thomas, Craig J Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Alkynes KW - Probes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39417908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Utilizing+a+Diazirine+and+Alkyne+Containing+Probe+in+a+Proof+of+Principle+Study+to+Investigate+Small+Molecule+Interactions+Across+the+Proteome&rft.au=LeClair%2C+Christopher+A%3BPrinz%2C+William+A%3BRaychaudhuri%2C+Sumana%3BThomas%2C+Craig+J&rft.aulast=LeClair&rft.aufirst=Christopher&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Deducing the Multiple Binding Modes of p53 Tetramer DNA Interaction Based on Full-site Palindrome of p53 Response Elements T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39414611; 4630255 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Ma, Buyong AU - Levine, Arnold J Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - P53 protein KW - Regulatory sequences KW - Palindromes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39414611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Deducing+the+Multiple+Binding+Modes+of+p53+Tetramer+DNA+Interaction+Based+on+Full-site+Palindrome+of+p53+Response+Elements&rft.au=Ma%2C+Buyong%3BLevine%2C+Arnold+J&rft.aulast=Ma&rft.aufirst=Buyong&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Generalization of the Gaussian Electrostatic Model: A Molecular Density Based Force Field T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39408615; 4630132 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Cisneros, G Andres AU - Piquemal, Jean-Philip AU - Darden, Thomas A Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Molecular modelling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39408615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Generalization+of+the+Gaussian+Electrostatic+Model%3A+A+Molecular+Density+Based+Force+Field&rft.au=Cisneros%2C+G+Andres%3BPiquemal%2C+Jean-Philip%3BDarden%2C+Thomas+A&rft.aulast=Cisneros&rft.aufirst=G&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proton Transfer Along Ordered Water Chains Inside Carbon Nanotubes T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39408558; 4630432 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Hummer, Gerhard AU - Hassan, Sergio A AU - Lee, Yong S AU - Dellago, Christoph Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Nanotechnology KW - Carbon KW - Protons KW - Nanotubes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39408558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Proton+Transfer+Along+Ordered+Water+Chains+Inside+Carbon+Nanotubes&rft.au=Hummer%2C+Gerhard%3BHassan%2C+Sergio+A%3BLee%2C+Yong+S%3BDellago%2C+Christoph&rft.aulast=Hummer&rft.aufirst=Gerhard&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Simulation of Interfacial Systems with Isotropic Periodical Sum T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39395100; 4630103 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Wu, Xiongwu AU - Klauda, Jeffery B AU - Pastor, Richard W AU - Brooks, Bernard R Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Simulation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39395100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Simulation+of+Interfacial+Systems+with+Isotropic+Periodical+Sum&rft.au=Wu%2C+Xiongwu%3BKlauda%2C+Jeffery+B%3BPastor%2C+Richard+W%3BBrooks%2C+Bernard+R&rft.aulast=Wu&rft.aufirst=Xiongwu&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phthalimide-Containing Hydrazides and Amides as Diketo Acid-Class HIV-1 Integrase Inhibitors T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39393775; 4637875 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Zhao, Xue Zhi AU - Semenova, Elena A AU - Vu, B Christie AU - Liao, Chenzhong AU - Nicklaus, Marc C AU - Hughes, Stephen H AU - Pommier, Yves AU - Burke Jr, Terrence R Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Amides KW - Integrase KW - Inhibitors KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39393775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Phthalimide-Containing+Hydrazides+and+Amides+as+Diketo+Acid-Class+HIV-1+Integrase+Inhibitors&rft.au=Zhao%2C+Xue+Zhi%3BSemenova%2C+Elena+A%3BVu%2C+B+Christie%3BLiao%2C+Chenzhong%3BNicklaus%2C+Marc+C%3BHughes%2C+Stephen+H%3BPommier%2C+Yves%3BBurke+Jr%2C+Terrence+R&rft.aulast=Zhao&rft.aufirst=Xue&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NIH Programs in Single Molecule Biophysics, Cellular Imaging and Nanoscience T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39389052; 4631505 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Lewis, Catherine Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Biophysics KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39389052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=NIH+Programs+in+Single+Molecule+Biophysics%2C+Cellular+Imaging+and+Nanoscience&rft.au=Lewis%2C+Catherine&rft.aulast=Lewis&rft.aufirst=Catherine&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Virtual Screening of the Inhibitors into Tyrosyl-DNA Phoshodiesterase (Tdp1) Active Sites T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39387339; 4637956 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Weidlich, Iwona E AU - Dexheimer, Thomas AU - Pommier, Yves AU - Merchand, Christophe AU - Nicklaus, Marc C Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Screening KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39387339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Virtual+Screening+of+the+Inhibitors+into+Tyrosyl-DNA+Phoshodiesterase+%28Tdp1%29+Active+Sites&rft.au=Weidlich%2C+Iwona+E%3BDexheimer%2C+Thomas%3BPommier%2C+Yves%3BMerchand%2C+Christophe%3BNicklaus%2C+Marc+C&rft.aulast=Weidlich&rft.aufirst=Iwona&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Solid-Liquid Multiphase Simulation in CHARMM with Simultaneous use of Class-I and Class-II Force Fields: Application to Peptide Adsorptions on Polymer Surfaces T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39385326; 4636472 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Biswas, Pradip Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Adsorption KW - Simulation KW - Polymers KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39385326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Solid-Liquid+Multiphase+Simulation+in+CHARMM+with+Simultaneous+use+of+Class-I+and+Class-II+Force+Fields%3A+Application+to+Peptide+Adsorptions+on+Polymer+Surfaces&rft.au=Biswas%2C+Pradip&rft.aulast=Biswas&rft.aufirst=Pradip&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Addiction and Brain Mechanisms T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39383675; 4637985 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Hoffer, Barry Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Brain KW - Addiction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39383675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Addiction+and+Brain+Mechanisms&rft.au=Hoffer%2C+Barry&rft.aulast=Hoffer&rft.aufirst=Barry&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synthesis of Conformationally Locked Versions of Puromycin as Tools to Understand the Role of Furanose Conformation in the Peptidyl Transfer Reaction T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39373615; 4638200 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Saneyoshi, Hisao AU - Choi, Yongseok AU - Strazewski, Peter AU - Marquez, Victor E Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Conformation KW - Puromycin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39373615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Synthesis+of+Conformationally+Locked+Versions+of+Puromycin+as+Tools+to+Understand+the+Role+of+Furanose+Conformation+in+the+Peptidyl+Transfer+Reaction&rft.au=Saneyoshi%2C+Hisao%3BChoi%2C+Yongseok%3BStrazewski%2C+Peter%3BMarquez%2C+Victor+E&rft.aulast=Saneyoshi&rft.aufirst=Hisao&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Imaging Probe Development Center: An NIH Roadmap Initiative to Promote Molecular Imaging Applications in Interdisciplinary Research T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39358572; 4633886 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Li, Haitao AU - Kaur, G AU - Shi, Z AU - Sulima, A AU - Teng, B AU - Vasalatiy, O AU - Wu, H. AU - Xu, B. AU - Cofiell, S AU - Neale, N AU - Ruddy, B AU - Wilson, C AU - Griffiths, G L Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Interdisciplinary research KW - Imaging techniques KW - Probes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39358572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=The+Imaging+Probe+Development+Center%3A+An+NIH+Roadmap+Initiative+to+Promote+Molecular+Imaging+Applications+in+Interdisciplinary+Research&rft.au=Li%2C+Haitao%3BKaur%2C+G%3BShi%2C+Z%3BSulima%2C+A%3BTeng%2C+B%3BVasalatiy%2C+O%3BWu%2C+H.%3BXu%2C+B.%3BCofiell%2C+S%3BNeale%2C+N%3BRuddy%2C+B%3BWilson%2C+C%3BGriffiths%2C+G+L&rft.aulast=Li&rft.aufirst=Haitao&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Study of the Chlorophenols Combustion in a Laboratory Scale Spouted Bed Incinerator T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39357875; 4633536 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Lin, Chieh AU - Wang, Ya-Hsin Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Incinerators KW - Combustion KW - Chlorophenols KW - Incineration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39357875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Study+of+the+Chlorophenols+Combustion+in+a+Laboratory+Scale+Spouted+Bed+Incinerator&rft.au=Lin%2C+Chieh%3BWang%2C+Ya-Hsin&rft.aulast=Lin&rft.aufirst=Chieh&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Packed Column Sfc: A Fast Separation Technique for the Clinical Laboratory T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39353996; 4632337 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Issaq, Haleem J AU - Xu, X. AU - Roman, J M AU - Abbott, E AU - Veenstra, T D Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Separation techniques KW - Separation processes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39353996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Packed+Column+Sfc%3A+A+Fast+Separation+Technique+for+the+Clinical+Laboratory&rft.au=Issaq%2C+Haleem+J%3BXu%2C+X.%3BRoman%2C+J+M%3BAbbott%2C+E%3BVeenstra%2C+T+D&rft.aulast=Issaq&rft.aufirst=Haleem&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modeling Alzheimer Amyloid Conformations and Toxicity T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39325815; 4631361 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Nussinov, Ruth AU - Jang, Hyunbum AU - Zheng, Jie AU - Ma, Buyong Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Toxicity KW - Amyloid KW - Neurodegenerative diseases KW - Conformation KW - Alzheimer's disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39325815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Modeling+Alzheimer+Amyloid+Conformations+and+Toxicity&rft.au=Nussinov%2C+Ruth%3BJang%2C+Hyunbum%3BZheng%2C+Jie%3BMa%2C+Buyong&rft.aulast=Nussinov&rft.aufirst=Ruth&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Targeted inhibition of glucuronidation markedly improves drug efficacy in mice-A model AN - 19728633; 7539064 AB - Finding UDP-glucuronosyltransferases (UGT) require protein kinase C-mediated phosphorylation is important information that allows manipulation of this critical system. UGTs glucuronidate numerous aromatic-like chemicals derived from metabolites, diet, environment and, inadvertently, therapeutics to reduce toxicities. As UGTs are inactivated by downregulating PKCs with reversibly-acting dietary curcumin, we determined the impact of gastro-intestinal glucuronidation on free-drug uptake and efficacy using immunosuppressant, mycophenolic acid (MPA), in mice. Expressed in COS-1 cells, mouse GI-distributed Ugt1a1 glucuronidates curcumin and MPA and undergoes irreversibly and reversibly dephosphorylation by PKC-specific inhibitor calphostin-C and general-kinase inhibitor curcumin, respectively, with parallel effects on activity. Moreover, oral curcumin-administration to mice reversibly inhibited glucuronidation in GI-tissues. Finally, successive oral administration of curcumin and MPA to antigen-treated mice increased serum free MPA and immunosuppression up to 9-fold. Results indicate targeted inhibition of GI glucuronidation in mice markedly improved free-chemical uptake and efficacy using MPA as a model. JF - Biochemical and Biophysical Research Communications AU - Basu, N K AU - Kole, L AU - Basu, M AU - McDonagh, A F AU - Owens, I S AD - National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 8D-42, Bethesda, MD 20892-1830, USA, basun@mail.nih.gov Y1 - 2007/08/17/ PY - 2007 DA - 2007 Aug 17 SP - 7 EP - 13 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 360 IS - 1 SN - 0006-291X, 0006-291X KW - Biotechnology and Bioengineering Abstracts KW - Diets KW - Protein kinase C KW - Curcumin KW - Mycophenolic acid KW - Dephosphorylation KW - UDP-glucuronosyltransferase KW - Oral administration KW - Metabolites KW - Toxicity KW - Immunosuppressive agents KW - Phosphorylation KW - Drugs KW - Immunosuppression KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19728633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Targeted+inhibition+of+glucuronidation+markedly+improves+drug+efficacy+in+mice-A+model&rft.au=Basu%2C+N+K%3BKole%2C+L%3BBasu%2C+M%3BMcDonagh%2C+A+F%3BOwens%2C+I+S&rft.aulast=Basu&rft.aufirst=N&rft.date=2007-08-17&rft.volume=360&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1016%2Fj.bbrc.2007.05.224 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Curcumin; Protein kinase C; Toxicity; Immunosuppressive agents; Diets; Oral administration; Dephosphorylation; Metabolites; UDP-glucuronosyltransferase; Mycophenolic acid; Phosphorylation; Drugs; Immunosuppression DO - http://dx.doi.org/10.1016/j.bbrc.2007.05.224 ER - TY - JOUR T1 - V-PROLI/NO, a prodrug of the nitric oxide donor, PROLI/NO. AN - 68151855; 17658755 AB - The sensitivity to decomposition of the nitric oxide (NO) donor ion, 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO), complicates direct electrophilic substitution to form useful prodrug derivatives. A modified general synthetic approach involving 1-[2-(hydroxymethyl)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate ion (structure A, above) was used to prepare several PROLI/NO prodrugs including the previously inaccessible O2-vinyl derivative, V-PROLI/NO. Metabolism of V-PROLI/NO by liver microsomes enriched in human cytochrome P450 isoforms was demonstrated. JF - Organic letters AU - Chakrapani, Harinath AU - Showalter, Brett M AU - Kong, Li AU - Keefer, Larry K AU - Saavedra, Joseph E AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. Y1 - 2007/08/16/ PY - 2007 DA - 2007 Aug 16 SP - 3409 EP - 3412 VL - 9 IS - 17 SN - 1523-7060, 1523-7060 KW - Nitric Oxide Donors KW - 0 KW - Prodrugs KW - Protein Isoforms KW - Vinyl Compounds KW - proline-nitric oxide KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Proline KW - 9DLQ4CIU6V KW - Index Medicus KW - Microsomes, Liver -- metabolism KW - Humans KW - Proline -- metabolism KW - Nitric Oxide Donors -- chemical synthesis KW - Prodrugs -- metabolism KW - Nitric Oxide Donors -- metabolism KW - Proline -- chemical synthesis KW - Proline -- analogs & derivatives KW - Prodrugs -- chemical synthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68151855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Organic+letters&rft.atitle=V-PROLI%2FNO%2C+a+prodrug+of+the+nitric+oxide+donor%2C+PROLI%2FNO.&rft.au=Chakrapani%2C+Harinath%3BShowalter%2C+Brett+M%3BKong%2C+Li%3BKeefer%2C+Larry+K%3BSaavedra%2C+Joseph+E&rft.aulast=Chakrapani&rft.aufirst=Harinath&rft.date=2007-08-16&rft.volume=9&rft.issue=17&rft.spage=3409&rft.isbn=&rft.btitle=&rft.title=Organic+letters&rft.issn=15237060&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-09 N1 - Date created - 2007-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Medical Abortion and the Risk of Subsequent Adverse Pregnancy Outcomes AN - 20449529; 7890519 AB - Background The long-term safety of surgical abortion in the first trimester is well established. Despite the increasing use of medical abortion (abortion by means of medication), limited information is available regarding the effects of this procedure on subsequent pregnancies. Methods We identified all women living in Denmark who had undergone an abortion for nonmedical reasons between 1999 and 2004 and obtained information regarding subsequent pregnancies from national registries. Risks of ectopic pregnancy, spontaneous abortion, preterm birth (at <37 weeks of gestation), and low birth weight (<2500 g) in the first subsequent pregnancy in women who had had a first-trimester medical abortion were compared with risks in women who had had a first-trimester surgical abortion. Results Among 11,814 pregnancies in women who had had a previous first-trimester medical abortion (2710 women) or surgical abortion (9104 women), there were 274 ectopic pregnancies (respective incidence rates, 2.4% and 2.3%), 1426 spontaneous abortions (12.2% and 12.7%), 552 preterm births (5.4% and 6.7%), and 478 births with low birth weight (4.0% and 5.1%). After adjustment for maternal age, interval between pregnancies, gestational age at abortion, parity, cohabitation status, and urban or nonurban residence, medical abortion was not associated with a significantly increased risk of ectopic pregnancy (relative risk, 1.04; 95% confidence interval [CI], 0.76 to 1.41), spontaneous abortion (relative risk, 0.87; 95% CI, 0.72 to 1.05), preterm birth (relative risk, 0.88; 95% CI, 0.66 to 1.18), or low birth weight (relative risk, 0.82; 95% CI, 0.61 to 1.11). Gestational age at medical abortion was not significantly associated with any of these adverse outcomes. Conclusions We found no evidence that a previous medical abortion, as compared with a previous surgical abortion, increases the risk of spontaneous abortion, ectopic pregnancy, preterm birth, or low birth weight. JF - New England Journal of Medicine AU - Virk, J AU - Zhang, J AU - Olsen, J AD - Epidemiology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bldg. 6100, Rm. 7B03, Bethesda, MD 20892, USA, zhangi@mail.nih.gov Y1 - 2007/08/16/ PY - 2007 DA - 2007 Aug 16 SP - 648 EP - 653 VL - 357 IS - 7 SN - 0028-4793, 0028-4793 KW - Risk Abstracts KW - Age KW - parity KW - cohabitation KW - Abortion KW - low-birth-weight KW - Denmark KW - Side effects KW - Pregnancy KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20449529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=New+England+Journal+of+Medicine&rft.atitle=Medical+Abortion+and+the+Risk+of+Subsequent+Adverse+Pregnancy+Outcomes&rft.au=Virk%2C+J%3BZhang%2C+J%3BOlsen%2C+J&rft.aulast=Virk&rft.aufirst=J&rft.date=2007-08-16&rft.volume=357&rft.issue=7&rft.spage=648&rft.isbn=&rft.btitle=&rft.title=New+England+Journal+of+Medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - parity; Age; cohabitation; Abortion; low-birth-weight; Side effects; Pregnancy; Denmark ER - TY - JOUR T1 - Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein. AN - 70704550; 17600340 AB - alpha-Synuclein, a gene whose mutations, duplication, and triplication has been linked to autosomal dominant familial Parkinson's disease (fPD), appears to play a central role in the pathogenesis of sporadic PD (sPD) as well. Enhancement of neurodegeneration induced by mutant alpha-synuclein has been attributed to date largely to faster formation of alpha-synuclein aggregates in neurons. Recently, we reported that microglial activation enhances wild type (WT) alpha-synuclein-elicited dopaminergic neurodegeneration. In the present study, using a primary mesencephalic culture system, we tested whether mutated alpha-synuclein could activate microglia more powerfully than WT alpha-synuclein, thereby contributing to the accelerated neurodegeneration observed in fPD. The results showed that alpha-synuclein with the A30P or A53T mutations caused greater microglial activation than WT alpha-synuclein. Furthermore, the extent of microglial activation paralleled the degree of dopaminergic neurotoxicity induced by WT and mutant alpha-synuclein. Mutant alpha-synuclein also induced greater production of reactive oxygen species than WT alpha-synuclein by NADPH oxidase (PHOX), and PHOX activation was linked to direct activation of macrophage antigen-1 (Mac-1) receptor, rather than alpha-synuclein internalization via scavenger receptors. These results have, for the first time, demonstrated that microglia are also critical in enhanced neurotoxicity induced by mutant alpha-synuclein. (c) 2007 Wiley-Liss, Inc. JF - Glia AU - Zhang, Wei AU - Dallas, Shannon AU - Zhang, Dan AU - Guo, Jian-Ping AU - Pang, Hao AU - Wilson, Belinda AU - Miller, David S AU - Chen, Biao AU - Zhang, Wanqin AU - McGeer, Patrick L AU - Hong, Jau-Shyong AU - Zhang, Jing AD - Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina, USA. Y1 - 2007/08/15/ PY - 2007 DA - 2007 Aug 15 SP - 1178 EP - 1188 VL - 55 IS - 11 SN - 0894-1491, 0894-1491 KW - Macrophage-1 Antigen KW - 0 KW - Reactive Oxygen Species KW - Synucleins KW - NADPH Oxidase KW - EC 1.6.3.1 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Oxygen Consumption -- drug effects KW - Neurotoxicity Syndromes -- physiopathology KW - Mice KW - Mesencephalon -- cytology KW - Rats KW - Mesencephalon -- drug effects KW - Rats, Inbred F344 KW - Cells, Cultured KW - Mutation -- physiology KW - Mice, Inbred C57BL KW - Immunohistochemistry KW - Synucleins -- toxicity KW - Synucleins -- genetics KW - Macrophage-1 Antigen -- physiology KW - Nerve Degeneration -- physiopathology KW - Dopamine -- physiology KW - Nerve Degeneration -- chemically induced KW - NADPH Oxidase -- physiology KW - Microglia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70704550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Glia&rft.atitle=Microglial+PHOX+and+Mac-1+are+essential+to+the+enhanced+dopaminergic+neurodegeneration+elicited+by+A30P+and+A53T+mutant+alpha-synuclein.&rft.au=Zhang%2C+Wei%3BDallas%2C+Shannon%3BZhang%2C+Dan%3BGuo%2C+Jian-Ping%3BPang%2C+Hao%3BWilson%2C+Belinda%3BMiller%2C+David+S%3BChen%2C+Biao%3BZhang%2C+Wanqin%3BMcGeer%2C+Patrick+L%3BHong%2C+Jau-Shyong%3BZhang%2C+Jing&rft.aulast=Zhang&rft.aufirst=Wei&rft.date=2007-08-15&rft.volume=55&rft.issue=11&rft.spage=1178&rft.isbn=&rft.btitle=&rft.title=Glia&rft.issn=08941491&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-18 N1 - Date created - 2007-07-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Family history of gallstones and the risk of biliary tract cancer and gallstones: a population-based study in Shanghai, China. AN - 70655597; 17450525 AB - Cancers of the biliary tract arise from the gallbladder, extrahepatic bile ducts and ampulla of Vater. Although relatively uncommon, the incidence of biliary tract cancer rose more than 100% in Shanghai, China between 1972 and 1994. Gallstones are the predominant risk factor for biliary tract cancers, with over 60% of the cancer cases having gallstones. A familial tendency to gallstones has been reported and may elevate the risk of gallbladder cancer further. As part of a large population-based case-control study of biliary tract cancers in Shanghai, China, we examined the association between a family history of gallstones and biliary tract cancers as well as biliary stones. A total of 627 biliary tract cancers (368 gallbladder, 191 bile duct, 68 ampulla of Vater), 1,037 biliary stone cases (774 gallbladder, 263 bile duct) and 959 healthy subjects randomly selected from the population were included in this study. Information on family history of gallstones among first-degree relatives (i.e., parents, siblings, offspring) was obtained through a self-reported history during in-person interviews. A family history of gallstones was associated with increased risks of biliary stones [odds ratio (OR) = 2.8, 95% confidence interval (CI) = 2.1-3.8], gallbladder cancer (OR = 2.1, 95% CI = 1.4-3.3) and bile duct cancer (OR = 1.5, 95% CI = 0.9-2.5), after adjustment for age, gender, marital status, education, smoking, alcohol drinking and body mass index. For gallbladder cancer, subjects with gallstones but without a family history of gallstones had a 21-fold risk (95% CI 14.8-30.1), while those with both gallstones and a positive family history had a 57-fold risk (95% CI 32.0-110.5). Significant risks for gallbladder cancer persisted after additional adjustment for gallstones, and when the analysis was restricted to subjects with first-degree relatives whose gallstones were treated with cholecystectomy. The significant associations with a family history of gallstones were seen for all first-degree relatives, including parents, siblings and offspring, but not spouses. This large population-based study not only supports the role of gallstones in biliary carcinogenesis but also suggests that the underlying genetic or lifestyle determinants of stones within families contribute to the risk of biliary tract cancer. JF - International journal of cancer AU - Hsing, Ann W AU - Bai, Yan AU - Andreotti, Gabriella AU - Rashid, Asif AU - Deng, Jie AU - Chen, Jinbo AU - Goldstein, Alisa M AU - Han, Tian-Quan AU - Shen, Ming-Chang AU - Fraumeni, Joseph F AU - Gao, Yu-Tang AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20852, USA. hsinga@mail.nih.gov Y1 - 2007/08/15/ PY - 2007 DA - 2007 Aug 15 SP - 832 EP - 838 VL - 121 IS - 4 SN - 0020-7136, 0020-7136 KW - Index Medicus KW - Risk Factors KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Family Health KW - Male KW - Female KW - China KW - Gallstones -- epidemiology KW - Biliary Tract Neoplasms -- epidemiology KW - Gallstones -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70655597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Family+history+of+gallstones+and+the+risk+of+biliary+tract+cancer+and+gallstones%3A+a+population-based+study+in+Shanghai%2C+China.&rft.au=Hsing%2C+Ann+W%3BBai%2C+Yan%3BAndreotti%2C+Gabriella%3BRashid%2C+Asif%3BDeng%2C+Jie%3BChen%2C+Jinbo%3BGoldstein%2C+Alisa+M%3BHan%2C+Tian-Quan%3BShen%2C+Ming-Chang%3BFraumeni%2C+Joseph+F%3BGao%2C+Yu-Tang&rft.aulast=Hsing&rft.aufirst=Ann&rft.date=2007-08-15&rft.volume=121&rft.issue=4&rft.spage=832&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-12 N1 - Date created - 2007-07-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Surg Laparosc Endosc Percutan Tech. 2004 Oct;14(5):250-3 [15492651] Annu Rev Genomics Hum Genet. 2000;1:507-37 [11701639] Science. 1986 Apr 4;232(4746):34-47 [3513311] Int J Cancer. 1988 May 15;41(5):657-60 [3366486] J Lipid Res. 1988 Apr;29(4):397-429 [3292686] Jpn J Cancer Res. 1989 Oct;80(10):932-8 [2515177] Int J Cancer. 1992 Jul 9;51(5):707-11 [1612778] Scand J Gastroenterol. 1994 Jul;29(7):577-82 [7939392] Hepatology. 1995 Jul;22(1):138-41 [7601405] Cancer. 1995 Nov 15;76(10):1747-56 [8625043] Int J Cancer. 1998 Jan 30;75(3):368-70 [9455795] Dig Dis Sci. 1998 Jun;43(6):1285-91 [9635619] Am J Gastroenterol. 1998 Sep;93(9):1420-4 [9732918] Gastroenterology. 1998 Oct;115(4):937-46 [9753497] Gastroenterol Clin North Am. 1999 Mar;28(1):99-115 [10198780] Dig Dis Sci. 1999 Aug;44(8):1619-25 [10492143] Zhonghua Wai Ke Za Zhi. 2005 Apr 1;43(7):455-9 [15854373] Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1315-8 [15894693] Int J Cancer. 2006 Jun 1;118(11):2847-53 [16381022] Int J Cancer. 2006 Jun 15;118(12):3089-94 [16395699] Carcinogenesis. 2006 Jun;27(6):1251-6 [16361272] Int J Cancer. 2007 May 1;120(9):1981-5 [17278101] Br J Cancer. 2007 Dec 3;97(11):1577-82 [18000509] CA Cancer J Clin. 2001 Nov-Dec;51(6):349-64 [11760569] Zhonghua Liu Xing Bing Xue Za Zhi. 2000 Feb;21(1):44-7 [11860758] Ann Surg. 2002 Jun;235(6):842-9 [12035041] Clin Cancer Res. 2002 Oct;8(10):3156-63 [12374683] Hum Genet. 2004 Feb;114(3):280-3 [14618390] Clin Cancer Res. 2004 Mar 1;10(5):1717-25 [15014024] Am J Clin Nutr. 2000 Nov;72(5 Suppl):1275S-1284S [11063469] Am J Gastroenterol. 1985 May;80(5):371-5 [3993637] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of a cytokine gene expression signature in lung adenocarcinoma and the surrounding tissue as a prognostic classifier. AN - 68172677; 17686824 AB - A 17-cytokine gene expression signature in noncancerous hepatic tissue from patients with metastatic hepatocellular carcinoma (HCC) was recently found to predict HCC metastasis and recurrence. We examined whether the cytokine gene expression profile of noncancerous lung tissue could predict the metastatic capability of adjacent lung adenocarcinoma. We analyzed a 15-cytokine gene expression profile in noncancerous lung tissue and corresponding lung tumor tissue from 80 US lung adenocarcinoma patients using real-time quantitative reverse transcription-polymerase chain reaction. We then used unsupervised hierarchical clustering and Prediction Analysis of Microarray classification to test the prognostic ability of the 15-cytokine gene profile in the US patients and in an independent validation set comprising 50 Japanese patients with stage I disease. Survival was analyzed by the Kaplan-Meier method using the log-rank test, and univariate and multivariable Cox proportional hazards modeling were used to analyze the association of clinical variables with patient survival. All statistical tests were two-sided. A 15-cytokine gene signature in noncancerous lung tissue primarily reflected the lymph node status of 80 lung adenocarcinoma patients, whereas the gene signature of the corresponding lung tumor tissue was associated with prognosis independent of lymph node status. Cytokine Lung Adenocarcinoma Survival Signature of 11 genes (CLASS-11), a refined 11-gene signature, accurately classified patients, including those with stage I disease, according to risk of death from adenocarcinoma. CLASS-11 prognostic classification was statistically significantly associated with survival and was an independent prognostic factor for stage I patients (hazard ratio for death in the high-risk CLASS-11 group compared with the low-risk CLASS-11 reference group = 7.46, 95% confidence interval = 2.14 to 26.05; P = .002). CLASS-11 also classified patients in the validation set according to risk of recurrence. CLASS-11, which consists of genes for pro- and anti-inflammatory cytokines, identifies stage I lung adenocarcinoma patients who have a poor prognosis. JF - Journal of the National Cancer Institute AU - Seike, Masahiro AU - Yanaihara, Nozomu AU - Bowman, Elise D AU - Zanetti, Krista A AU - Budhu, Anuradha AU - Kumamoto, Kensuke AU - Mechanic, Leah E AU - Matsumoto, Shingo AU - Yokota, Jun AU - Shibata, Tatsuhiro AU - Sugimura, Haruhiko AU - Gemma, Akihiko AU - Kudoh, Shoji AU - Wang, Xin W AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4258, USA. Y1 - 2007/08/15/ PY - 2007 DA - 2007 Aug 15 SP - 1257 EP - 1269 VL - 99 IS - 16 KW - Cytokines KW - 0 KW - Index Medicus KW - Neoplasm Staging KW - Humans KW - Prognosis KW - Lymph Nodes -- pathology KW - Lung -- pathology KW - Lung -- metabolism KW - Male KW - Female KW - Gene Expression Profiling KW - Cytokines -- genetics KW - Adenocarcinoma -- mortality KW - Adenocarcinoma -- classification KW - Adenocarcinoma -- secondary KW - Lung Neoplasms -- mortality KW - Lung Neoplasms -- classification KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68172677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Use+of+a+cytokine+gene+expression+signature+in+lung+adenocarcinoma+and+the+surrounding+tissue+as+a+prognostic+classifier.&rft.au=Seike%2C+Masahiro%3BYanaihara%2C+Nozomu%3BBowman%2C+Elise+D%3BZanetti%2C+Krista+A%3BBudhu%2C+Anuradha%3BKumamoto%2C+Kensuke%3BMechanic%2C+Leah+E%3BMatsumoto%2C+Shingo%3BYokota%2C+Jun%3BShibata%2C+Tatsuhiro%3BSugimura%2C+Haruhiko%3BGemma%2C+Akihiko%3BKudoh%2C+Shoji%3BWang%2C+Xin+W%3BHarris%2C+Curtis+C&rft.aulast=Seike&rft.aufirst=Masahiro&rft.date=2007-08-15&rft.volume=99&rft.issue=16&rft.spage=1257&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-05 N1 - Date created - 2007-08-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pseudohypoxic pathways in renal cell carcinoma. AN - 68166368; 17699843 AB - Mutations of the von Hippel-Lindau (VHL) or fumarate hydratase (FH) genes lead to morphologically different renal cell carcinomas with distinct clinical courses and outcomes. The VHL protein is a part of an ubiquitin ligase complex that targets proteins for proteosomal degradation. FH is one of the mitochondrial enzymes of the Kreb's cycle. Despite two different functionalities and cellular locations, loss of either VHL or FH products has been shown to alter expression levels of hypoxia-inducible factors (HIF-1alpha and HIF-2alpha) and their downstream targets. HIF proteins are key regulators of oxygen homeostasis. Tight regulation of HIF allows for cell survival and growth at the time of hypoxic stress. HIF acts via transcriptional regulation of vascular endothelial growth factor, platelet derived growth factor, endothelial growth factor receptor, glucose transporter protein 1, erythropoietin, and transforming growth factor-alpha. Loss of VHL or FH is thought to result in a pseudohypoxic state so that cellular response pathways mediated by HIF are activated despite normal oxygen conditions. Understanding of these pseudohypoxic pathways has provided a better appreciation of the molecular mechanisms of carcinogenesis in addition to providing a rationale for targeted therapeutic approaches. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Bratslavsky, Gennady AU - Sudarshan, Sunil AU - Neckers, Len AU - Linehan, W Marston AD - Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-1107, USA. Y1 - 2007/08/15/ PY - 2007 DA - 2007 Aug 15 SP - 4667 EP - 4671 VL - 13 IS - 16 SN - 1078-0432, 1078-0432 KW - HIG1 protein, human KW - 0 KW - Neoplasm Proteins KW - Von Hippel-Lindau Tumor Suppressor Protein KW - EC 2.3.2.27 KW - Fumarate Hydratase KW - EC 4.2.1.2 KW - VHL protein, human KW - EC 6.3.2.- KW - Index Medicus KW - Animals KW - Neoplasm Proteins -- physiology KW - Fumarate Hydratase -- physiology KW - Von Hippel-Lindau Tumor Suppressor Protein -- physiology KW - Humans KW - Von Hippel-Lindau Tumor Suppressor Protein -- genetics KW - Fumarate Hydratase -- genetics KW - Kidney Neoplasms -- genetics KW - Carcinoma, Renal Cell -- etiology KW - Kidney Neoplasms -- etiology KW - Cell Hypoxia KW - Carcinoma, Renal Cell -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68166368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Pseudohypoxic+pathways+in+renal+cell+carcinoma.&rft.au=Bratslavsky%2C+Gennady%3BSudarshan%2C+Sunil%3BNeckers%2C+Len%3BLinehan%2C+W+Marston&rft.aulast=Bratslavsky&rft.aufirst=Gennady&rft.date=2007-08-15&rft.volume=13&rft.issue=16&rft.spage=4667&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-25 N1 - Date created - 2007-08-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Using risk-based sampling to enrich cohorts for endpoints, genes, and exposures. AN - 68100913; 17556763 AB - Targeting the first-degree relatives of people with a particular complex disease can offer a powerful approach to building a risk-based cohort for prospective studies of etiologic factors. Such a cohort provides both a sizable increase in the rate of accrual of newly incident cases, enriching for risk factors that are known or even unknown, and a high level of motivation among participants. A nationwide study of breast cancer in the United States and Puerto Rico, the Sister Study, made up of women who are each the sister of a woman with breast cancer, exemplifies this approach. In this paper, the authors provide power calculations to aid in the design of such studies and quantify their benefits for detecting both genetic variants related to risk and interactive effects of genetic and environmental factors. While the risk-based cohort can have markedly increased prevalences of rare causative alleles, most of the power advantages for this design is due to the increased rate of accrual of newly incident cases rather than the increase in any one individual allele. JF - American journal of epidemiology AU - Weinberg, Clarice R AU - Shore, David L AU - Umbach, David M AU - Sandler, Dale P AD - Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. weinberg@niehs.nih.gov Y1 - 2007/08/15/ PY - 2007 DA - 2007 Aug 15 SP - 447 EP - 455 VL - 166 IS - 4 SN - 0002-9262, 0002-9262 KW - Index Medicus KW - Breast Neoplasms -- genetics KW - Genetic Variation KW - Disease Susceptibility KW - Endpoint Determination KW - Gene Frequency KW - Humans KW - Breast Neoplasms -- epidemiology KW - Genotype KW - Risk KW - Prospective Studies KW - Breast Neoplasms -- etiology KW - Siblings KW - Female KW - Prevalence KW - Cohort Studies KW - Environmental Exposure -- adverse effects KW - Epidemiologic Research Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68100913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Using+risk-based+sampling+to+enrich+cohorts+for+endpoints%2C+genes%2C+and+exposures.&rft.au=Weinberg%2C+Clarice+R%3BShore%2C+David+L%3BUmbach%2C+David+M%3BSandler%2C+Dale+P&rft.aulast=Weinberg&rft.aufirst=Clarice&rft.date=2007-08-15&rft.volume=166&rft.issue=4&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-31 N1 - Date created - 2007-07-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genet Epidemiol. 2003 Nov;25(3):190-202 [14557987] N Engl J Med. 2000 Jul 13;343(2):78-85 [10891514] J Natl Cancer Inst. 2006 Apr 5;98(7):436-8 [16595777] Br J Cancer. 2006 Jun 5;94(11):1734-7 [16641898] Am J Hum Genet. 2000 Jan;66(1):251-61 [10631155] Lancet. 2001 Oct 27;358(9291):1389-99 [11705483] Pediatrics. 2004 May;113(5):e472-86 [15121991] Epidemiology. 2005 May;16(3):294-303 [15824543] Am J Epidemiol. 1998 Nov 1;148(9):893-901 [9801020] Stat Med. 1997 Jan 15-Feb 15;16(1-3):103-16 [9004386] Am J Epidemiol. 1992 Nov 1;136(9):1138-47 [1462973] Am J Epidemiol. 1991 Aug 15;134(4):421-32 [1877602] Lancet. 1980 Feb 16;1(8164):339-40 [6101792] Am J Epidemiol. 1982 Jan;115(1):119-28 [7055123] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intramedullary spinal tumor causing belly dancer syndrome AN - 21164539; 11350395 AB - Abstract not available. JF - Movement Disorders AU - Shamim, Ejaz A AU - Hallett, Mark AD - Human Motor Control Section, National Institute of Neurologic Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA, shamime@ninds.nih.gov Y1 - 2007/08/15/ PY - 2007 DA - 2007 Aug 15 SP - 1673 EP - 1674 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 22 IS - 11 SN - 0885-3185, 0885-3185 KW - Physical Education Index; CSA Neurosciences Abstracts KW - Movement disorders KW - Abdomen KW - Tumors KW - PE 110:Physical Therapy KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21164539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+Disorders&rft.atitle=Intramedullary+spinal+tumor+causing+belly+dancer+syndrome&rft.au=Shamim%2C+Ejaz+A%3BHallett%2C+Mark&rft.aulast=Shamim&rft.aufirst=Ejaz&rft.date=2007-08-15&rft.volume=22&rft.issue=11&rft.spage=1673&rft.isbn=&rft.btitle=&rft.title=Movement+Disorders&rft.issn=08853185&rft_id=info:doi/10.1002%2Fmds.21280 LA - English DB - Physical Education Index N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Abdomen; Tumors; Movement disorders DO - http://dx.doi.org/10.1002/mds.21280 ER - TY - JOUR T1 - Correlates of 'Non-Problematic' and 'Problematic' Substance Use Among Depressed Adolescents in Primary Care AN - 57090218; 200802066 AB - Substance use and related problems were assessed in a sample of primary care patients (n = 450) ages 13-21 who screened positive for depression at a clinic visit. Patients were classified as having no substance use (n = 248), non-problematic use (substance use without reported school, work, social, or family problems, n = 90), or use that reportedly caused problems in at least one area (n = 112). In logistic regression models, older age, externalizing symptoms, and not being African American were significantly associated with non-problematic use; older age, male gender, externalizing symptoms, Caucasian/White ethnicity/race, and more friends were associated with problematic use. Odds ratios were similar for patients reporting non-problematic and problematic use, suggesting that, in the presence of depression, any substance use merits evaluation and monitoring to determine treatment needs and to prevent escalation of dysfunction. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Journal of Addictive Diseases AU - Goldstein, Rise B AU - Asarnow, Joan R AU - Jaycox, Lisa H AU - Shoptaw, Steven AU - Murray, Pamela J AD - MPH, Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20892-9304 Y1 - 2007/08/14/ PY - 2007 DA - 2007 Aug 14 SP - 39 EP - 52 PB - Haworth Press, Binghamton NY VL - 26 IS - 3 SN - 1055-0887, 1055-0887 KW - Depression KW - Emotionally disturbed adolescents KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57090218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Addictive+Diseases&rft.atitle=Correlates+of+%27Non-Problematic%27+and+%27Problematic%27+Substance+Use+Among+Depressed+Adolescents+in+Primary+Care&rft.au=Goldstein%2C+Rise+B%3BAsarnow%2C+Joan+R%3BJaycox%2C+Lisa+H%3BShoptaw%2C+Steven%3BMurray%2C+Pamela+J&rft.aulast=Goldstein&rft.aufirst=Rise&rft.date=2007-08-14&rft.volume=26&rft.issue=3&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Journal+of+Addictive+Diseases&rft.issn=10550887&rft_id=info:doi/10.1300%2FJ069v26n03_05 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-02-04 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDER N1 - SubjectsTermNotLitGenreText - Emotionally disturbed adolescents; Depression; Substance abuse DO - http://dx.doi.org/10.1300/J069v26n03_05 ER - TY - JOUR T1 - The human Mi-2/NuRD complex and gene regulation. AN - 68157500; 17694084 AB - The Mi-2/nucleosome remodeling and deacetylase (NuRD) complex is an abundant deacetylase complex with a broad cellular and tissue distribution. It is unique in that it couples histone deacetylation and chromatin remodeling ATPase activities in the same complex. A decade of research has uncovered a number of interesting connections between Mi-2/NuRD and gene regulation. The subunit composition of the enzyme appears to vary with cell type and in response to physiologic signals within a tissue. Here, we review the known subunits of the complex, their connections to signaling networks, and their association with cancer. In addition, we propose a working model that integrates the known biochemical properties of the enzyme with emerging models on how chromatin structure and modification relate to gene activity. JF - Oncogene AU - Denslow, S A AU - Wade, P A AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. Y1 - 2007/08/13/ PY - 2007 DA - 2007 Aug 13 SP - 5433 EP - 5438 VL - 26 IS - 37 SN - 0950-9232, 0950-9232 KW - Autoantigens KW - 0 KW - CHD4 protein, human KW - Neoplasm Proteins KW - Repressor Proteins KW - Histone Deacetylases KW - EC 3.5.1.98 KW - Mi-2 Nucleosome Remodeling and Deacetylase Complex KW - Adenosine Triphosphatases KW - EC 3.6.1.- KW - DNA Helicases KW - EC 3.6.4.- KW - Index Medicus KW - Animals KW - DNA Methylation KW - Humans KW - Repressor Proteins -- metabolism KW - Retinoblastoma -- metabolism KW - Neoplasm Proteins -- metabolism KW - Neoplasms -- pathology KW - Neoplasms -- enzymology KW - DNA Helicases -- metabolism KW - Histone Deacetylases -- metabolism KW - DNA Helicases -- genetics KW - Adenosine Triphosphatases -- metabolism KW - Autoantigens -- genetics KW - Gene Expression Regulation KW - Autoantigens -- metabolism KW - Histone Deacetylases -- genetics KW - Adenosine Triphosphatases -- genetics KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68157500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=The+human+Mi-2%2FNuRD+complex+and+gene+regulation.&rft.au=Denslow%2C+S+A%3BWade%2C+P+A&rft.aulast=Denslow&rft.aufirst=S&rft.date=2007-08-13&rft.volume=26&rft.issue=37&rft.spage=5433&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-24 N1 - Date created - 2007-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Restoration of 3,4-methylenedioxymethamphetamine-induced 5-HT depletion by the administration of L-5-hydroxytryptophan. AN - 68160304; 17629409 AB - 3,4-Methylenedioxymethamphetamine (MDMA) causes persistent decreases in brain 5-HT content and 5-HT transporter (SERT) binding, with no detectable changes in SERT protein. Such data suggest that MDMA impairs 5-HT transmission but leaves 5-HT nerve terminals intact. To further test this hypothesis, we carried out two types of experiments in rats exposed to high-dose MDMA. First, we examined the effects of MDMA on SERT binding and function using different in vitro assay conditions. Next, we treated rats with the 5-HT precursor, l-5-hydroxytryptophan (5-HTP), in an attempt to restore MDMA-induced depletions of 5-HT. Rats received three i.p. injections of saline or MDMA (7.5 mg/kg), one injection every 2 h. Rats in one group were decapitated, and brain tissue was assayed for SERT binding and [(3)H]5-HT uptake under conditions of normal (100 or 126 mM) and low (20 mM) NaCl concentration. Rats from another group received saline or 5-hydroxytryptophan/benserazide (5-HTP-B), each drug at 50 mg/kg i.p., and were killed 2 h later. MDMA reduced SERT binding to 10% of control when assayed in 100 mM NaCl, but this reduction was only 55% of control in 20 mM NaCl. MDMA decreased immunoreactive 5-HT in caudate and hippocampus to about 35% of control. Administration of 5-HTP-B to MDMA-pretreated rats significantly increased the 5-HT signal toward normal levels in caudate (85% of control) and hippocampus (66% of control). 1) Following high-dose MDMA treatment sufficient to reduce SERT binding by 90%, a significant number of functionally intact 5-HT nerve terminals survive. 2) The degree of MDMA-induced decreases in SERT binding depends on the in vitro assay conditions. 3) 5-HTP-B restores brain 5-HT depleted by MDMA, suggesting that this approach might be clinically useful in abstinent MDMA users. JF - Neuroscience AU - Wang, X AU - Baumann, M H AU - Dersch, C M AU - Rothman, R B AD - Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, P.O. Box 5180, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. Y1 - 2007/08/10/ PY - 2007 DA - 2007 Aug 10 SP - 212 EP - 220 VL - 148 IS - 1 SN - 0306-4522, 0306-4522 KW - Antidepressive Agents, Second-Generation KW - 0 KW - Hallucinogens KW - Serotonin Agents KW - Serotonin Plasma Membrane Transport Proteins KW - Serotonin KW - 333DO1RDJY KW - 5-Hydroxytryptophan KW - C1LJO185Q9 KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Index Medicus KW - Animals KW - Nerve Degeneration -- physiopathology KW - Serotonin Plasma Membrane Transport Proteins -- drug effects KW - Nerve Degeneration -- chemically induced KW - Recovery of Function -- physiology KW - Radioligand Assay KW - Recovery of Function -- drug effects KW - Presynaptic Terminals -- metabolism KW - Nerve Degeneration -- drug therapy KW - Rats KW - Presynaptic Terminals -- drug effects KW - Cell Survival -- drug effects KW - Male KW - Hallucinogens -- antagonists & inhibitors KW - Antidepressive Agents, Second-Generation -- pharmacology KW - Serotonin Plasma Membrane Transport Proteins -- metabolism KW - Dose-Response Relationship, Drug KW - Synaptic Transmission -- drug effects KW - Binding, Competitive -- physiology KW - Binding, Competitive -- drug effects KW - Synaptic Transmission -- physiology KW - Drug Interactions -- physiology KW - Rats, Sprague-Dawley KW - Serotonin Agents -- pharmacology KW - Serotonin Agents -- toxicity KW - Hallucinogens -- toxicity KW - Cell Survival -- physiology KW - Brain Chemistry -- drug effects KW - Brain -- drug effects KW - 5-Hydroxytryptophan -- pharmacology KW - N-Methyl-3,4-methylenedioxyamphetamine -- toxicity KW - Brain -- metabolism KW - N-Methyl-3,4-methylenedioxyamphetamine -- antagonists & inhibitors KW - Serotonin -- deficiency KW - Brain Chemistry -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68160304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Restoration+of+3%2C4-methylenedioxymethamphetamine-induced+5-HT+depletion+by+the+administration+of+L-5-hydroxytryptophan.&rft.au=Wang%2C+X%3BBaumann%2C+M+H%3BDersch%2C+C+M%3BRothman%2C+R+B&rft.aulast=Wang&rft.aufirst=X&rft.date=2007-08-10&rft.volume=148&rft.issue=1&rft.spage=212&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-14 N1 - Date created - 2007-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity. AN - 68127673; 17678736 AB - We aimed to explore the effects of pharmacologic inhibition of cannabinoid-1 (CB1) receptor in in vivo and in vitro models of doxorubicin (DOX)-induced cardiotoxicity. Doxorubicin is one of the most potent antitumor agents available; however, its clinical use is limited because of the risk of severe cardiotoxicity. Endocannabinoids mediate cardiodepressive effects through CB1 receptors in various pathophysiological conditions, and these effects can be reversed by CB1 antagonists. Left ventricular function was measured by Millar pressure-volume system. Apoptosis markers, CB1/CB2 receptor expression, and endocannabinoid levels were determined by immunohistochemistry, Western blot, reverse transcription-polymerase chain reaction, real-time polymerase chain reaction, flow cytometry, fluorescent microscopy, and liquid chromatography/in-line mass spectrometry techniques. Five days after the administration of a single dose of DOX (20 mg/kg intraperitoneally) to mice, left ventricular systolic pressure, maximum first derivative of ventricular pressure with respect to time (+dP/dt), stroke work, ejection fraction, cardiac output, and load-independent indexes of contractility (end-systolic pressure-volume relation, preload-recruitable stroke work, dP/dt-end-diastolic volume relation) were significantly depressed, and the myocardial level of the endocannabinoid anandamide (but not CB1/CB2 receptor expression) was elevated compared with vehicle-treated control mice. Treatment with the CB1 antagonists rimonabant or AM281 markedly improved cardiac dysfunction and reduced DOX-induced apoptosis in the myocardium. Doxorubicin also decreased cell viability and induced apoptosis in the H9c2 myocardial cell line measured by flow cytometry and fluorescent microscopy, which were prevented by the preincubation of the cells with either CB1 antagonist, but not with CB1 and CB2 agonists and CB2 antagonists. These data suggest that CB1 antagonists may represent a new cardioprotective strategy against DOX-induced cardiotoxicity. JF - Journal of the American College of Cardiology AU - Mukhopadhyay, Partha AU - Bátkai, Sándor AU - Rajesh, Mohanraj AU - Czifra, Nora AU - Harvey-White, Judith AU - Haskó, György AU - Zsengeller, Zsuzsanna AU - Gerard, Norma P AU - Liaudet, Lucas AU - Kunos, George AU - Pacher, Pál AD - Laboratory of Physiological Studies, NIH/NIAAA, Bethesda, Maryland 20892, USA. Y1 - 2007/08/07/ PY - 2007 DA - 2007 Aug 07 SP - 528 EP - 536 VL - 50 IS - 6 KW - AM 281 KW - 0 KW - Antibiotics, Antineoplastic KW - Cannabinoid Receptor Modulators KW - Morpholines KW - Piperidines KW - Pyrazoles KW - Receptor, Cannabinoid, CB1 KW - Receptor, Cannabinoid, CB2 KW - Doxorubicin KW - 80168379AG KW - rimonabant KW - RML78EN3XE KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Myocytes, Cardiac -- drug effects KW - Mice KW - Myocardium -- metabolism KW - Receptor, Cannabinoid, CB2 -- antagonists & inhibitors KW - Cannabinoid Receptor Modulators -- metabolism KW - Apoptosis -- drug effects KW - Mice, Inbred C57BL KW - DNA Fragmentation -- drug effects KW - Receptor, Cannabinoid, CB2 -- agonists KW - Receptor, Cannabinoid, CB2 -- drug effects KW - Cell Line KW - Male KW - Piperidines -- pharmacology KW - Pyrazoles -- pharmacology KW - Heart Failure -- prevention & control KW - Doxorubicin -- adverse effects KW - Receptor, Cannabinoid, CB1 -- antagonists & inhibitors KW - Receptor, Cannabinoid, CB1 -- agonists KW - Piperidines -- therapeutic use KW - Morpholines -- therapeutic use KW - Receptor, Cannabinoid, CB1 -- drug effects KW - Morpholines -- pharmacology KW - Heart Failure -- chemically induced KW - Pyrazoles -- therapeutic use KW - Antibiotics, Antineoplastic -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68127673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.atitle=Pharmacological+inhibition+of+CB1+cannabinoid+receptor+protects+against+doxorubicin-induced+cardiotoxicity.&rft.au=Mukhopadhyay%2C+Partha%3BB%C3%A1tkai%2C+S%C3%A1ndor%3BRajesh%2C+Mohanraj%3BCzifra%2C+Nora%3BHarvey-White%2C+Judith%3BHask%C3%B3%2C+Gy%C3%B6rgy%3BZsengeller%2C+Zsuzsanna%3BGerard%2C+Norma+P%3BLiaudet%2C+Lucas%3BKunos%2C+George%3BPacher%2C+P%C3%A1l&rft.aulast=Mukhopadhyay&rft.aufirst=Partha&rft.date=2007-08-07&rft.volume=50&rft.issue=6&rft.spage=528&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Cardiology&rft.issn=1558-3597&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-24 N1 - Date created - 2007-08-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Antioxid Redox Signal. 2001 Feb;3(1):135-45 [11291592] Physiol Rev. 2007 Jan;87(1):315-424 [17237348] J Am Coll Cardiol. 2001 Dec;38(7):2048-54 [11738314] Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2380-5 [11854531] J Pharmacol Exp Ther. 2002 Mar;300(3):862-7 [11861791] Cancer Res. 2002 Aug 15;62(16):4592-8 [12183413] J Mol Cell Cardiol. 2002 Dec;34(12):1595-607 [12505058] Circulation. 2003 Feb 18;107(6):896-904 [12591762] Br J Pharmacol. 2003 Apr;138(7):1251-8 [12711625] Oncol Rep. 2004 Feb;11(2):505-8 [14719091] J Leukoc Biol. 2004 Mar;75(3):453-9 [14657208] Circulation. 2004 Mar 23;109(11):1428-33 [15023870] Science. 1977 Jul 8;197(4299):165-7 [877547] N Engl J Med. 1981 Jul 16;305(3):139-53 [7017406] J Biol Chem. 1986 Mar 5;261(7):3068-74 [3005279] Drugs. 1997;54 Suppl 4:1-7 [9361955] N Engl J Med. 1998 Sep 24;339(13):900-5 [9744975] Circulation. 2004 Nov 2;110(18):2869-74 [15505089] N Engl J Med. 2005 Nov 17;353(20):2121-34 [16291982] JAMA. 2006 Feb 15;295(7):761-75 [16478899] Handb Exp Pharmacol. 2005;(168):599-625 [16596789] Pharmacol Res. 2006 Apr;53(4):341-6 [16455267] Arch Mal Coeur Vaiss. 2006 Mar;99(3):242-6 [16618028] Circulation. 2006 May 9;113(18):2211-20 [16651473] J Am Coll Cardiol. 2006 May 16;47(10):1919-26 [16697306] J Pharmacol Sci. 2006 Jun;101(2):151-8 [16766856] Eur Heart J. 2006 Aug;27(15):1868-75 [16717080] Pharmacol Rev. 2006 Sep;58(3):389-462 [16968947] J Mol Cell Cardiol. 2006 Sep;41(3):389-405 [16879835] Comment In: J Am Coll Cardiol. 2007 Aug 7;50(6):537-9 [17678737] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease AN - 20406802; 7560371 AB - Gaucher disease is an autosomal recessive lysosomal storage disorder caused by mutations in the glucocerebrosidase gene. Missense mutations result in reduced enzyme activity that may be due to misfolding, raising the possibility of small-molecule chaperone correction of the defect. Screening large compound libraries by quantitative high-throughput screening (qHTS) provides comprehensive information on the potency, efficacy, and structure-activity relationships (SAR) of active compounds directly from the primary screen, facilitating identification of leads for medicinal chemistry optimization. We used qHTS to rapidly identify three structural series of potent, selective, nonsugar glucocerebrosidase inhibitors. The three structural classes had excellent potencies and efficacies and, importantly, high selectivity against closely related hydrolases. Preliminary SAR data were used to select compounds with high activity in both enzyme and cell-based assays. Compounds from two of these structural series increased N370S mutant glucocerebrosidase activity by 40-90% in patient cell lines and enhanced lysosomal colocalization, indicating chaperone activity. These small molecules have potential as leads for chaperone therapy for Gaucher disease, and this paradigm promises to accelerate the development of leads for other rare genetic disorders. JF - Proceedings of the National Academy of Sciences, USA AU - Zheng, Wei AU - Padia, Janak AU - Urban, Daniel J AU - Jadhav, Ajit AU - Goker-Alpan, Ozlem AU - Simeonov, Anton AU - Goldin, Ehud AU - Auld, Douglas AU - LaMarca, Mary E AU - Inglese, James AU - Austin, Christopher P AU - Sidransky, Ellen AD - NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, MSC 3370, Bethesda, MD 20892-3370 Y1 - 2007/08/07/ PY - 2007 DA - 2007 Aug 07 SP - 13192 EP - 13197 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 32 SN - 0027-8424, 0027-8424 KW - Biotechnology Research Abstracts (through 1992) KW - hydrolase KW - lysosomal storage diseases KW - Missense mutation KW - Hereditary diseases KW - Gaucher's disease KW - Enzymes KW - high-throughput screening KW - Chaperones KW - Glucosylceramidase KW - Structure-activity relationships KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20406802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Three+classes+of+glucocerebrosidase+inhibitors+identified+by+quantitative+high-throughput+screening+are+chaperone+leads+for+Gaucher+disease&rft.au=Zheng%2C+Wei%3BPadia%2C+Janak%3BUrban%2C+Daniel+J%3BJadhav%2C+Ajit%3BGoker-Alpan%2C+Ozlem%3BSimeonov%2C+Anton%3BGoldin%2C+Ehud%3BAuld%2C+Douglas%3BLaMarca%2C+Mary+E%3BInglese%2C+James%3BAustin%2C+Christopher+P%3BSidransky%2C+Ellen&rft.aulast=Zheng&rft.aufirst=Wei&rft.date=2007-08-07&rft.volume=104&rft.issue=32&rft.spage=13192&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Chaperones; Glucosylceramidase; Gaucher's disease; Enzymes; high-throughput screening; Missense mutation; lysosomal storage diseases; Hereditary diseases; hydrolase; Structure-activity relationships ER - TY - JOUR T1 - Viewpoint: mechanisms of action and therapeutic potential of neurohormetic phytochemicals. AN - 733227867; 18648607 AB - The nervous system is of fundamental importance in the adaptive (hormesis) responses of organisms to all types of stress, including environmental "toxins". Phytochemicals present in vegetables and fruits are believed to reduce the risk of several major diseases including cardiovascular disease, cancers and neurodegenerative disorders. Although antioxidant properties have been suggested as the basis of health benefits of phytochemicals, emerging findings suggest a quite different mechanism of action. Many phytochemicals normally function as toxins that protect the plants against insects and other damaging organisms. However, at the relatively low doses consumed by humans and other mammals these same "toxic" phytochemicals activate adaptive cellular stress response pathways that can protect the cells against a variety of adverse conditions. Recent findings have elucidated hormetic mechanisms of action of phytochemicals (e.g., resveratrol, curcumin, sulforaphanes and catechins) using cell culture and animal models of neurological disorders. Examples of hormesis pathways activated by phytochemicals include the transcription factor Nrf-2 which activates genes controlled by the antioxidant response element, and histone deacetylases of the sirtuin family and FOXO transcription factors. Such hormetic pathways stimulate the production of antioxidant enzymes, protein chaperones and neurotrophic factors. In several cases neurohormetic phytochemicals have been shown to suppress the disease process in animal models relevant to neurodegenerative disorders such as Alzheimer's and Parkinson's diseases, and can also improve outcome following a stroke. We are currently screening a panel of biopesticides in order to establish hormetic doses, neuroprotective efficacy, mechanisms of action and therapeutic potential as dietary supplements. JF - Dose-response : a publication of International Hormesis Society AU - Mattson, Mark P AU - Son, Tae Gen AU - Camandola, Simonetta AD - Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA. mattsonm@grc.nia.nih.gov Y1 - 2007/08/06/ PY - 2007 DA - 2007 Aug 06 SP - 174 EP - 186 VL - 5 IS - 3 KW - neurotrophic factor KW - Alzheimer's disease KW - resveratrol KW - nrf2 KW - sirtuin KW - curcumin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733227867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dose-response+%3A+a+publication+of+International+Hormesis+Society&rft.atitle=Viewpoint%3A+mechanisms+of+action+and+therapeutic+potential+of+neurohormetic+phytochemicals.&rft.au=Mattson%2C+Mark+P%3BSon%2C+Tae+Gen%3BCamandola%2C+Simonetta&rft.aulast=Mattson&rft.aufirst=Mark&rft.date=2007-08-06&rft.volume=5&rft.issue=3&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=Dose-response+%3A+a+publication+of+International+Hormesis+Society&rft.issn=1559-3258&rft_id=info:doi/10.2203%2Fdose-response.07-004.Mattson LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-09 N1 - Date created - 2008-07-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci Res. 1999 Jul 1;57(1):48-61 [10397635] Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10367-72 [9294217] Cardiovasc Drug Rev. 2004 Fall;22(3):169-88 [15492766] Free Radic Biol Med. 2004 Nov 15;37(10):1578-90 [15477009] Trends Neurosci. 2004 Oct;27(10):589-94 [15374669] Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10446-51 [15229324] Amyotroph Lateral Scler Other Motor Neuron Disord. 2004 Mar;5(1):33-9 [15204022] J Neurosci Res. 2005 Nov 15;82(4):499-506 [16211562] Pharmacol Biochem Behav. 2005 Sep;82(1):200-6 [16171853] J Neurosci Res. 2005 Oct 1;82(1):138-48 [16075466] Neuromolecular Med. 2005;7(1-2):37-50 [16052037] Planta. 2005 Jul;221(5):603-6 [15931500] J Neurochem. 2005 Jun;93(5):1209-19 [15934941] Curr Biol. 2005 May 24;15(10):929-34 [15916949] Crit Rev Food Sci Nutr. 2004;44(2):97-111 [15116757] Science. 2004 Mar 26;303(5666):2011-5 [14976264] J Neurosci. 2004 Feb 4;24(5):1101-12 [14762128] Nature. 2004 Jan 15;427(6971):260-5 [14712238] Mol Cell Biol. 2003 Nov;23(22):8137-51 [14585973] J Neurosci Res. 2006 Sep;84(4):699-715 [16862541] Ann N Y Acad Sci. 2006 May;1067:425-35 [16804022] Neuromolecular Med. 2006;8(3):389-414 [16775390] Am J Pathol. 2003 Nov;163(5):1997-2008 [14578199] Psychopharmacology (Berl). 2003 Sep;169(2):115-34 [12827346] Am J Clin Nutr. 2003 Sep;78(3 Suppl):570S-578S [12936951] Nat Med. 2003 Aug;9(8):1062-8 [12858170] Nutr Neurosci. 2003 Jun;6(3):153-62 [12793519] Neuromolecular Med. 2003;3(2):65-94 [12728191] Biochem J. 2003 May 1;371(Pt 3):887-95 [12570874] Free Radic Biol Med. 2003 Apr 15;34(8):1100-10 [12684095] Curr Opin Plant Biol. 2003 Apr;6(2):185-90 [12667877] J Neurochem. 2002 Sep;82(6):1367-75 [12354284] Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11908-13 [12193649] Hum Exp Toxicol. 2002 Feb;21(2):91-7 [12102503] Physiol Rev. 2002 Jul;82(3):637-72 [12087131] J Neurosci. 2001 Dec 1;21(23):9204-13 [11717354] J Neurosci. 2001 Nov 1;21(21):8370-7 [11606625] Life Sci. 2001 Jul 20;69(9):1057-65 [11508648] J Neurosci. 2001 May 1;21(9):2929-38 [11312276] Br J Pharmacol. 2000 Oct;131(4):711-20 [11030720] Eur J Epidemiol. 2000 Apr;16(4):357-63 [10959944] J Cereb Blood Flow Metab. 1999 Dec;19(12):1296-308 [10598933] Toxicol Appl Pharmacol. 2007 Jul 1;222(1):122-8 [17459441] Amino Acids. 2007;32(3):299-304 [16998712] J Pharmacol Exp Ther. 2007 Apr;321(1):249-56 [17259450] Aging Cell. 2007 Feb;6(1):35-43 [17156081] Biochem Pharmacol. 2007 Feb 15;73(4):550-60 [17147953] Brain Res. 2007 Jan 12;1128(1):61-9 [17140550] Cell. 2006 Dec 15;127(6):1109-22 [17112576] J Biol Chem. 2006 Dec 8;281(49):37391-403 [17035241] Nutrition. 2006 Nov-Dec;22(11-12):1177-84 [17027231] Neurobiol Dis. 2006 Dec;24(3):506-15 [17010630] Nature. 2006 Nov 16;444(7117):337-42 [17086191] FASEB J. 2006 Nov;20(13):2313-20 [17077308] Trends Neurosci. 2006 Nov;29(11):632-9 [17000014] Eur J Clin Nutr. 2006 Oct;60(10):1145-59 [16670693] Ageing Res Rev. 2006 Aug;5(3):332-53 [16899414] Ageing Res Rev. 2006 May;5(2):165-78 [16682262] Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):395-403 [16677086] J Neurosci. 2006 Apr 26;26(17):4509-18 [16641230] Cell Death Differ. 2006 May;13(5):852-60 [16397579] Neurosci Lett. 2005 Dec 2;389(2):99-103 [16098661] Handb Exp Pharmacol. 2005;(168):53-79 [16596771] Crit Rev Toxicol. 2005 Jul;35(6):463-582 [16422392] Exp Neurol. 2006 Feb;197(2):309-17 [16364299] Neurosci Lett. 2006 Jan 30;393(2-3):108-12 [16233958] J Alzheimers Dis. 2005 Dec;8(3):283-7 [16340085] Proc Nutr Soc. 2005 Nov;64(4):565-70 [16313699] Ann Thorac Surg. 2005 Dec;80(6):2242-9 [16305881] Exp Neurol. 2005 Dec;196(2):298-307 [16176814] J Biol Chem. 2005 Nov 11;280(45):37377-82 [16162502] J Biol Chem. 2005 May 27;280(21):20589-95 [15788402] Neurobiol Dis. 2005 Jun-Jul;19(1-2):96-107 [15837565] Brain Res Mol Brain Res. 2005 Apr 4;134(2):215-25 [15836919] Exp Neurol. 2005 May;193(1):75-84 [15817266] Nat Genet. 2005 Apr;37(4):349-50 [15793589] Curr Opin Clin Nutr Metab Care. 2005 Mar;8(2):139-46 [15716791] Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18171-6 [15604149] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2203/dose-response.07-004.Mattson ER - TY - JOUR T1 - Paradoxes in carcinogenesis: new opportunities for research directions. AN - 68313338; 17683619 AB - The prevailing paradigm in cancer research is the somatic mutation theory that posits that cancer begins with a single mutation in a somatic cell followed by successive mutations. Much cancer research involves refining the somatic mutation theory with an ever increasing catalog of genetic changes. The problem is that such research may miss paradoxical aspects of carcinogenesis for which there is no likely explanation under the somatic mutation theory. These paradoxical aspects offer opportunities for new research directions that should not be ignored. Various paradoxes related to the somatic mutation theory of carcinogenesis are discussed: (1) the presence of large numbers of spatially distinct precancerous lesions at the onset of promotion, (2) the large number of genetic instabilities found in hyperplastic polyps not considered cancer, (3) spontaneous regression, (4) higher incidence of cancer in patients with xeroderma pigmentosa but not in patients with other comparable defects in DNA repair, (5) lower incidence of many cancers except leukemia and testicular cancer in patients with Down's syndrome, (6) cancer developing after normal tissue is transplanted to other parts of the body or next to stroma previously exposed to carcinogens, (7) the lack of tumors when epithelial cells exposed to a carcinogen were transplanted next to normal stroma, (8) the development of cancers when Millipore filters of various pore sizes were was inserted under the skin of rats, but only if the holes were sufficiently small. For the latter paradox, a microarray experiment is proposed to try to better understand the phenomena. The famous physicist Niels Bohr said "How wonderful that we have met with a paradox. Now we have some hope of making progress." The same viewpoint should apply to cancer research. It is easy to ignore this piece of wisdom about the means to advance knowledge, but we do so at our peril. JF - BMC cancer AU - Baker, Stuart G AU - Kramer, Barnett S AD - Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA. sb16i@nih.gov Y1 - 2007/08/06/ PY - 2007 DA - 2007 Aug 06 SP - 151 VL - 7 KW - Carcinogens KW - 0 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Rats KW - Neoplasm Regression, Spontaneous KW - Carcinogens -- pharmacology KW - Animals KW - DNA Repair KW - Humans KW - Mutation KW - Neoplasms -- pathology KW - Research -- trends KW - Neoplasms -- genetics KW - Neoplasms -- etiology KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68313338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+cancer&rft.atitle=Paradoxes+in+carcinogenesis%3A+new+opportunities+for+research+directions.&rft.au=Baker%2C+Stuart+G%3BKramer%2C+Barnett+S&rft.aulast=Baker&rft.aufirst=Stuart&rft.date=2007-08-06&rft.volume=7&rft.issue=&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=BMC+cancer&rft.issn=1471-2407&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-16 N1 - Date created - 2007-09-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14675-7 [10611270] Proc Natl Acad Sci U S A. 1976 Feb;73(2):549-53 [1061157] Proc Natl Acad Sci U S A. 1986 Dec;83(23):8878-82 [3466163] Cancer Res. 1994 Oct 15;54(20):5296-300 [7923156] J Cell Biol. 1997 Apr 7;137(1):231-45 [9105051] Technol Health Care. 1997 Oct;5(4):331-4 [9429273] Cancer Res. 1998 Oct 1;58(19):4314-23 [9766659] Cell. 1999 Jul 23;98(2):137-46 [10428026] Int J Cancer. 2005 Jan 1;113(1):168-70 [15386432] Br Med Bull. 1958 May;14(2):99-101 [13536368] Lancet. 1962 Jul 21;2(7247):107-12 [14484229] Prog Exp Tumor Res. 1964;5:85-133 [14317768] Lancet. 2005 Feb 5-11;365(9458):488-92 [15705458] J Biosci. 2005 Feb;30(1):103-18 [15824446] Breast Cancer. 2005;12(2):140-4 [15858446] Cancer Biol Ther. 2005 Jun;4(6):621-7 [15970666] Int J Cancer. 2006 Apr 1;118(7):1769-72 [16231334] BMC Bioinformatics. 2006;7:407 [16959042] J Mol Histol. 2006 Sep;37(5-7):225-38 [16855787] Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15121-6 [10611348] Lancet. 2000 Jan 15;355(9199):165-9 [10675114] Cancer Res. 2000 Mar 1;60(5):1254-60 [10728684] Mol Carcinog. 2000 Dec;29(4):205-11 [11170258] Lancet. 2002 Mar 23;359(9311):1019-25 [11937181] Nat Rev Cancer. 2004 Mar;4(3):197-205 [14993901] J Cell Sci. 2004 Mar 15;117(Pt 8):1495-502 [14996910] Bioessays. 2004 Oct;26(10):1097-107 [15382143] J Natl Cancer Inst. 1966 Aug;37(2):145-51 [5912611] J Natl Cancer Inst. 1972 Apr;48(4):1251-4 [5023683] J Natl Cancer Inst. 1973 Oct;51(4):1275-85 [4583375] Nature. 1981 Jan 29;289(5796):353-7 [6258076] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A trial of 17 alpha-hydroxyprogesterone caproate to prevent prematurity in twins. AN - 68121816; 17671253 AB - In singleton gestations, 17 alpha-hydroxyprogesterone caproate (17P) has been shown to reduce the rate of recurrent preterm birth. This study was undertaken to evaluate whether 17P would reduce the rate of preterm birth in twin gestations. We performed a randomized, double-blind, placebo-controlled trial in 14 centers. Healthy women with twin gestations were assigned to weekly intramuscular injections of 250 mg of 17P or matching placebo, starting at 16 to 20 weeks of gestation and ending at 35 weeks. The primary study outcome was delivery or fetal death before 35 weeks of gestation. Six hundred sixty-one women were randomly assigned to treatment. Baseline demographic data were similar in the two study groups. Six women were lost to follow-up; data from 655 were analyzed (325 in the 17P group and 330 in the placebo group). Delivery or fetal death before 35 weeks occurred in 41.5% of pregnancies in the 17P group and 37.3% of those in the placebo group (relative risk, 1.1; 95% confidence interval [CI], 0.9 to 1.3). The rate of the prespecified composite outcome of serious adverse fetal or neonatal events was 20.2% in the 17P group and 18.0% in the placebo group (relative risk, 1.1; 95% CI, 0.9 to 1.5). Side effects of the injections were frequent in both groups, occurring in 65.9% and 64.4% of subjects, respectively (P=0.69), but were generally mild and limited to the injection site. Treatment with 17 alpha-hydroxyprogesterone caproate did not reduce the rate of preterm birth in women with twin gestations. (ClinicalTrials.gov number, NCT00099164 [ClinicalTrials.gov].). Copyright 2007 Massachusetts Medical Society. JF - The New England journal of medicine AU - Rouse, Dwight J AU - Caritis, Steve N AU - Peaceman, Alan M AU - Sciscione, Anthony AU - Thom, Elizabeth A AU - Spong, Catherine Y AU - Varner, Michael AU - Malone, Fergal AU - Iams, Jay D AU - Mercer, Brian M AU - Thorp, John AU - Sorokin, Yoram AU - Carpenter, Marshall AU - Lo, Julie AU - Ramin, Susan AU - Harper, Margaret AU - Anderson, Garland AU - National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network AD - Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham 35249-7333, USA. drouse@uab.edu ; National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network Y1 - 2007/08/02/ PY - 2007 DA - 2007 Aug 02 SP - 454 EP - 461 VL - 357 IS - 5 KW - Hydroxyprogesterones KW - 0 KW - Progesterone Congeners KW - 17-alpha-hydroxy-progesterone caproate KW - 276F2O42F5 KW - Abridged Index Medicus KW - Index Medicus KW - Treatment Failure KW - Double-Blind Method KW - Humans KW - Injections, Intramuscular KW - Adult KW - Female KW - Pregnancy Outcome KW - Pregnancy KW - Hydroxyprogesterones -- therapeutic use KW - Twins KW - Progesterone Congeners -- adverse effects KW - Premature Birth -- prevention & control KW - Pregnancy, Multiple KW - Hydroxyprogesterones -- adverse effects KW - Progesterone Congeners -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68121816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=A+trial+of+17+alpha-hydroxyprogesterone+caproate+to+prevent+prematurity+in+twins.&rft.au=Rouse%2C+Dwight+J%3BCaritis%2C+Steve+N%3BPeaceman%2C+Alan+M%3BSciscione%2C+Anthony%3BThom%2C+Elizabeth+A%3BSpong%2C+Catherine+Y%3BVarner%2C+Michael%3BMalone%2C+Fergal%3BIams%2C+Jay+D%3BMercer%2C+Brian+M%3BThorp%2C+John%3BSorokin%2C+Yoram%3BCarpenter%2C+Marshall%3BLo%2C+Julie%3BRamin%2C+Susan%3BHarper%2C+Margaret%3BAnderson%2C+Garland%3BNational+Institute+of+Child+Health+and+Human+Development+Maternal-Fetal+Medicine+Units+Network&rft.aulast=Rouse&rft.aufirst=Dwight&rft.date=2007-08-02&rft.volume=357&rft.issue=5&rft.spage=454&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-09 N1 - Date created - 2007-08-02 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - NCT00099164; ClinicalTrials.gov N1 - SuppNotes - Comment In: N Engl J Med. 2007 Nov 29;357(22):2306; author reply 2307 [18050514] N Engl J Med. 2007 Aug 2;357(5):499-501 [17671259] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells AN - 21335173; 11935012 AB - Epithelial stem cells in the bulge region within the hair follicle maintain the cyclic hair growth, but whether these stem cells also contribute to the epidermal renewal remains unclear. Here, we observed that the conditional deletion of the Rac1 gene in the mouse skin, including the potential follicular and epidermal stem cell compartments, results in alopecia owing to defective hair development. Surprisingly, mice lacking the expression of this Rho GTPase do not display major alterations in the interfollicular skin. Furthermore, Rac1 excision from primary epithelial keratinocytes results in the inability to reconstitute hair follicles and sebaceous glands when grafted onto mice, but epithelial cells lacking Rac1 can nonetheless form a healthy epidermis. Together, these findings support the emerging view that the epidermis and the hair follicles are maintained by different epithelial stem cells, and provide evidence that the requirement for Rac1 function can distinguish these distinct stem cells populations.Oncogene (2007) 26, 5078-5085; doi:10.1038/sj.onc.1210322; published online 5 March 2007 JF - Oncogene AU - Castilho, R M AU - Squarize, C H AU - Patel, V AU - Millar, S E AU - Zheng, Y AU - Molinolo, A AU - Gutkind, J S AD - 1 Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA Y1 - 2007/08/02/ PY - 2007 DA - 2007 Aug 02 SP - 5078 EP - 5085 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 26 IS - 35 SN - 0950-9232, 0950-9232 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Oncogenes & Growth Factors Abstracts KW - Epithelial cells KW - Skin KW - Follicles KW - Rac1 protein KW - Hair KW - Sebaceous gland KW - Epidermis KW - Stem cells KW - Gene deletion KW - Alopecia KW - Keratinocytes KW - Guanosinetriphosphatase KW - B 26610:Guanine nucleotide-binding proteins KW - G 07730:Development & Cell Cycle KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21335173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Requirement+of+Rac1+distinguishes+follicular+from+interfollicular+epithelial+stem+cells&rft.au=Castilho%2C+R+M%3BSquarize%2C+C+H%3BPatel%2C+V%3BMillar%2C+S+E%3BZheng%2C+Y%3BMolinolo%2C+A%3BGutkind%2C+J+S&rft.aulast=Castilho&rft.aufirst=R&rft.date=2007-08-02&rft.volume=26&rft.issue=35&rft.spage=5078&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/10.1038%2Fsj.onc.1210322 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Epidermis; Gene deletion; Stem cells; Skin; Follicles; Alopecia; Rac1 protein; Keratinocytes; Hair; Sebaceous gland; Guanosinetriphosphatase DO - http://dx.doi.org/10.1038/sj.onc.1210322 ER - TY - JOUR T1 - Adult mesenchymal stem cells: biological properties, characteristics, and applications in maxillofacial surgery. AN - 85395728; pmid-17656295 JF - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons AU - Shanti, Rabie M AU - Li, Wan-Ju AU - Nesti, Leon J AU - Wang, Xibin AU - Tuan, Rocky S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 1640 EP - 1647 VL - 65 IS - 8 SN - 0278-2391, 0278-2391 KW - National Library of Medicine KW - Adult Stem Cells: cytology KW - *Adult Stem Cells: physiology KW - Biocompatible Materials KW - Bone Substitutes KW - Cells, Cultured KW - Hematopoietic Stem Cells: cytology KW - Hematopoietic Stem Cells: physiology KW - Humans KW - Mesenchymal Stem Cells: cytology KW - *Mesenchymal Stem Cells: physiology KW - *Prosthesis Design: methods KW - *Reconstructive Surgical Procedures: methods KW - *Surgery, Oral: methods KW - *Tissue Engineering: methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85395728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+oral+and+maxillofacial+surgery+%3A+official+journal+of+the+American+Association+of+Oral+and+Maxillofacial+Surgeons&rft.atitle=Adult+mesenchymal+stem+cells%3A+biological+properties%2C+characteristics%2C+and+applications+in+maxillofacial+surgery.&rft.au=Shanti%2C+Rabie+M%3BLi%2C+Wan-Ju%3BNesti%2C+Leon+J%3BWang%2C+Xibin%3BTuan%2C+Rocky+S&rft.aulast=Shanti&rft.aufirst=Rabie&rft.date=2007-08-01&rft.volume=65&rft.issue=8&rft.spage=1640&rft.isbn=&rft.btitle=&rft.title=Journal+of+oral+and+maxillofacial+surgery+%3A+official+journal+of+the+American+Association+of+Oral+and+Maxillofacial+Surgeons&rft.issn=02782391&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Hemodynamic and cognitive effects of lofexidine and methadone coadministration: a pilot study. AN - 70766273; 17655511 AB - To determine the hemodynamic and cognitive effects of lofexidine and methadone coadministration. Prospective, double-blind study. Outpatient drug treatment research clinic. Fourteen participants (aged 18-45 yrs) with physical dependence on opioids. Subjects were stabilized on methadone maintenance therapy, starting with 30 mg/day and increasing by 10-mg/day increments, based on each subject's tolerability to achieve a target dose of 80 mg/day. After 3 weeks of methadone stabilization, lofexidine 0.4 mg/day or matching placebo were coadministered with methadone, in doses escalating by 0.2-mg/week increments, to achieve a target dose of 1.6 mg/day over the next 8 weeks. Acute orthostatic vital signs and neuropsychological effects of lofexidine and methadone coadministration were monitored for 5 hours after the dose on the first day of each new lofexidine dose. Orthostatic vital signs and adverse events were assessed daily thereafter to determine the effects of repeated doses. Lofexidine significantly decreased sitting systolic and diastolic blood pressure (p=0.045 and p=0.033, respectively) compared with placebo (i.e., methadone alone). With lofexidine 0.4 mg/day, mean decreases in systolic and diastolic blood pressure were 27 +/- 17 and 15 +/- 16 mm Hg, respectively. No significant association was noted between changes in orthostatic vital signs and lofexidine dose. Decreased cognitive efficiency was associated with lofexidine administration, and higher lofexidine doses adversely affected performance on a mathematical task compared with placebo (p=0.0035). The rate of adverse events was no higher with lofexidine than with placebo; the majority (54.3%) were common adverse effects of lofexidine. Significant changes in hemodynamic and cognitive efficiency were observed with coadministration of lofexidine and methadone compared with methadone alone. When patients receiving methadone are prescribed lofexidine, they should be closely monitored for cardiovascular and cognitive changes. JF - Pharmacotherapy AU - Schroeder, Jennifer R AU - Schmittner, John AU - Bleiberg, Joseph AU - Epstein, David H AU - Krantz, Mori J AU - Preston, Kenzie L AD - Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1111 EP - 1119 VL - 27 IS - 8 SN - 0277-0008, 0277-0008 KW - Narcotic Antagonists KW - 0 KW - Narcotics KW - Clonidine KW - MN3L5RMN02 KW - Methadone KW - UC6VBE7V1Z KW - lofexidine KW - UI82K0T627 KW - Index Medicus KW - Drug Interactions KW - Double-Blind Method KW - Dose-Response Relationship, Drug KW - Humans KW - Pilot Projects KW - Prospective Studies KW - Adult KW - Substance Withdrawal Syndrome -- drug therapy KW - Middle Aged KW - Blood Pressure -- drug effects KW - Adolescent KW - Female KW - Male KW - Methadone -- adverse effects KW - Clonidine -- administration & dosage KW - Clonidine -- analogs & derivatives KW - Clonidine -- adverse effects KW - Narcotics -- adverse effects KW - Narcotics -- administration & dosage KW - Methadone -- administration & dosage KW - Narcotics -- pharmacology KW - Methadone -- pharmacology KW - Narcotic Antagonists -- administration & dosage KW - Cognition -- drug effects KW - Narcotic Antagonists -- adverse effects KW - Clonidine -- pharmacology KW - Narcotic Antagonists -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70766273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Hemodynamic+and+cognitive+effects+of+lofexidine+and+methadone+coadministration%3A+a+pilot+study.&rft.au=Schroeder%2C+Jennifer+R%3BSchmittner%2C+John%3BBleiberg%2C+Joseph%3BEpstein%2C+David+H%3BKrantz%2C+Mori+J%3BPreston%2C+Kenzie+L&rft.aulast=Schroeder&rft.aufirst=Jennifer&rft.date=2007-08-01&rft.volume=27&rft.issue=8&rft.spage=1111&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-11 N1 - Date created - 2007-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sorafenib and sunitinib: novel targeted therapies for renal cell cancer. AN - 70761347; 17655513 AB - Renal cell cancer (RCC) is a relatively uncommon malignancy, with 51,190 cases expected to be diagnosed in 2007. Localized disease is curable by surgery; however, locally advanced or metastatic disease is not curable in most cases and, until recently, had a limited response to drug treatment. Historically, biologic response modifiers or immunomodulating agents were tested in clinical trials based on observations that some cases of RCC can spontaneously regress. High-dose aldesleukin is approved by the United States Food and Drug Administration as a treatment for advanced RCC; however, the drug is associated with a high frequency of severe adverse effects. Responses have been observed with low-dose aldesleukin and interferon alfa, but with little effect on overall survival. Sorafenib and sunitinib are novel therapies that target growth factor receptors known to be activated by the hypoxia-inducible factor and the Ras-Raf/MEK/ERK pathways. These pathways are important in the pathophysiology of RCC. Sorafenib and sunitinib have shown antitumor activity as first- and second-line therapy in patients with cytokine-refractory metastatic RCC who have clear-cell histology. Although complete responses are not common, both drugs promote disease stabilization and increase progression-free survival. This information suggests that disease stabilization may be an important determinant for response in RCC and possibly other cancers. Sorafenib and sunitinib are generally well tolerated and are considered first- and second-line treatment options for patients with advanced clear cell RCC. In addition, sorafenib and sunitinib have shown promising results in initial clinical trials evaluating antitumor activity in patients who are refractory to other antiangiogenic therapy. The most common toxicities with both sorafenib and sunitinib are hand-foot syndrome, rash, fatigue, hypertension, and diarrhea. Research is directed toward defining the optimal use of these new agents. JF - Pharmacotherapy AU - Grandinetti, Cheryl A AU - Goldspiel, Barry R AD - Pharmaceutical Management Branch, Cancer Therapy Evaluation Program, National Cancer Institute, Rockville, Maryland 20852, USA. grandinettic@ctep.nci.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1125 EP - 1144 VL - 27 IS - 8 SN - 0277-0008, 0277-0008 KW - Antineoplastic Agents KW - 0 KW - Benzenesulfonates KW - Indoles KW - Phenylurea Compounds KW - Pyridines KW - Pyrroles KW - Receptors, Growth Factor KW - Niacinamide KW - 25X51I8RD4 KW - sorafenib KW - 9ZOQ3TZI87 KW - sunitinib KW - V99T50803M KW - Index Medicus KW - Drug Delivery Systems KW - Drug Interactions KW - Humans KW - Niacinamide -- analogs & derivatives KW - Clinical Trials as Topic KW - Receptors, Growth Factor -- drug effects KW - Pyrroles -- adverse effects KW - Kidney Neoplasms -- drug therapy KW - Benzenesulfonates -- therapeutic use KW - Pyrroles -- pharmacokinetics KW - Pyridines -- pharmacokinetics KW - Antineoplastic Agents -- pharmacokinetics KW - Indoles -- adverse effects KW - Pyridines -- therapeutic use KW - Carcinoma, Renal Cell -- drug therapy KW - Pyrroles -- therapeutic use KW - Carcinoma, Renal Cell -- physiopathology KW - Antineoplastic Agents -- adverse effects KW - Benzenesulfonates -- adverse effects KW - Indoles -- pharmacokinetics KW - Benzenesulfonates -- pharmacokinetics KW - Indoles -- therapeutic use KW - Kidney Neoplasms -- physiopathology KW - Antineoplastic Agents -- therapeutic use KW - Pyridines -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70761347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Sorafenib+and+sunitinib%3A+novel+targeted+therapies+for+renal+cell+cancer.&rft.au=Grandinetti%2C+Cheryl+A%3BGoldspiel%2C+Barry+R&rft.aulast=Grandinetti&rft.aufirst=Cheryl&rft.date=2007-08-01&rft.volume=27&rft.issue=8&rft.spage=1125&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-11 N1 - Date created - 2007-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cadmium-induced toxicity in rat primary mid-brain neuroglia cultures: role of oxidative stress from microglia. AN - 70761298; 17483498 AB - This study examined the role of oxidative stress in neurotoxic effects of cadmium chloride (Cd) in rat primary mid-brain neuron-glia cultures. Cd accumulated in neuron-glia cultures and produced cytotoxicity in a dose-dependent manner, with IC(50) of 2.5microM 24 h after exposure. (3)H-dopamine uptake into neuron-glia cultures was decreased 7 days after Cd exposure, with IC(50) of 0.9microM, indicative of the sensitivity of dopaminergic neurons to Cd toxicity. To investigate the role of microglia in Cd-induced toxicity to neurons, microglia-enriched cultures were prepared. Cd significantly increased intracellular reactive oxygen species production in microglia-enriched cultures, as evidenced by threefold increases in 2',7'-dichlorofluorescein signals. Using 5,5-dimethyl-1-pyrroline N-oxide as a spin-trapping agent, Cd increased electron spin resonance signals by 3.5-fold in microglia-enriched cultures. Cd-induced oxidative stress to microglia-enriched cultures was further evidenced by activation of redox-sensitive transcription factor nuclear factor kappa B and activator protein-1 (AP-1), and the increased expression of oxidative stress-related genes, such as metallothionein, heme oxygenase-1, glutathione S-transferase pi, and metal transport protein-1, as determined by gel-shift assays and real-time reverse transcription-PCR, respectively, in microglia-enriched cultures. In conclusion, Cd is toxic to neuron-glia cultures, and the oxidative stress from microglia may play important roles in Cd-induced damage to dopaminergic neurons. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Yang, Zhengqin AU - Yang, Sufen AU - Qian, Steven Y AU - Hong, Jau-Shyong AU - Kadiiska, Maria B AU - Tennant, Raymond W AU - Waalkes, Michael P AU - Liu, Jie AD - Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 488 EP - 494 VL - 98 IS - 2 SN - 1096-6080, 1096-6080 KW - Cation Transport Proteins KW - 0 KW - NF-kappa B KW - Reactive Oxygen Species KW - Transcription Factor AP-1 KW - metal transporting protein 1 KW - metallothionein 2 protein, rat KW - Cadmium KW - 00BH33GNGH KW - Metallothionein KW - 9038-94-2 KW - Heme Oxygenase-1 KW - EC 1.14.14.18 KW - Glutathione S-Transferase pi KW - EC 2.5.1.18 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Reactive Oxygen Species -- metabolism KW - Transcription Factor AP-1 -- metabolism KW - Metallothionein -- genetics KW - Heme Oxygenase-1 -- genetics KW - Mesencephalon -- cytology KW - Cation Transport Proteins -- genetics KW - Glutathione S-Transferase pi -- genetics KW - Rats KW - Rats, Inbred F344 KW - Cells, Cultured KW - NF-kappa B -- metabolism KW - Neuroglia -- metabolism KW - Oxidative Stress KW - Cadmium -- toxicity KW - Dopamine -- metabolism KW - Neuroglia -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70761298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Cadmium-induced+toxicity+in+rat+primary+mid-brain+neuroglia+cultures%3A+role+of+oxidative+stress+from+microglia.&rft.au=Yang%2C+Zhengqin%3BYang%2C+Sufen%3BQian%2C+Steven+Y%3BHong%2C+Jau-Shyong%3BKadiiska%2C+Maria+B%3BTennant%2C+Raymond+W%3BWaalkes%2C+Michael+P%3BLiu%2C+Jie&rft.aulast=Yang&rft.aufirst=Zhengqin&rft.date=2007-08-01&rft.volume=98&rft.issue=2&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-19 N1 - Date created - 2007-07-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharmacol Exp Ther. 2000 May;293(2):607-17 [10773035] Nat Rev Neurosci. 2007 Jan;8(1):57-69 [17180163] Brain Res. 2001 Feb 16;892(1):102-10 [11172754] Cell Biol Toxicol. 2000;16(6):347-62 [11254161] Int J Occup Environ Health. 2001 Apr-Jun;7(2):109-12 [11373040] Free Radic Biol Med. 2002 Mar 15;32(6):525-35 [11958953] Food Chem Toxicol. 2003 Mar;41(3):379-84 [12504170] Methods Mol Med. 2003;79:387-95 [12506711] Brain Res Mol Brain Res. 2003 Jan 31;110(1):76-84 [12573535] Br J Pharmacol. 2003 Mar;138(5):901-11 [12642392] Mutat Res. 2003 Dec 10;533(1-2):107-20 [14643415] Free Radic Biol Med. 2004 Jun 1;36(11):1434-43 [15135180] Free Radic Biol Med. 2004 Nov 1;37(9):1463-71 [15454286] J Neuropathol Exp Neurol. 1981 May;40(3):247-57 [7218003] Toxicol Appl Pharmacol. 1982 May;63(3):330-7 [7101297] Brain Res. 1986 Apr 9;370(2):354-8 [3011199] J Clin Exp Neuropsychol. 1989 Dec;11(6):933-43 [2592532] Cancer Res. 1991 Feb 1;51(3):974-8 [1988141] Arch Int Physiol Biochim. 1990 Oct;98(5):291-6 [1708997] Toxicol Appl Pharmacol. 1991 Sep 1;110(2):347-54 [1891778] Arch Toxicol. 1993;67(7):491-6 [8239998] Toxicology. 1995 Dec 15;104(1-3):141-7 [8560492] Toxicology. 1996 Sep 2;112(3):219-26 [8845042] J Neurophysiol. 1996 Nov;76(5):3264-73 [8930271] Toxicol Lett. 1996 Dec;89(1):65-9 [8952713] Free Radic Biol Med. 1997;22(3):471-8 [8981039] Clin Neurol Neurosurg. 1997 Dec;99(4):263-5 [9491302] Arch Toxicol. 1998 Nov;72(11):690-700 [9879806] Annu Rev Pharmacol Toxicol. 1999;39:267-94 [10331085] Toxicology. 1999 Mar 1;133(1):43-58 [10413193] Ann Neurol. 1999 Oct;46(4):598-605 [10514096] Toxicol Lett. 2005 Jan 15;155(1):87-96 [15585363] Int J Cancer. 2005 Apr 10;114(3):346-55 [15551354] Free Radic Biol Med. 2006 Mar 15;40(6):968-75 [16540392] J Pharmacol Exp Ther. 2006 Nov;319(2):595-603 [16891616] Brain Res. 2000 Jan 31;854(1-2):224-9 [10784126] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - ELR+-CXC chemokines and their receptors in early metanephric development. AN - 70759080; 17634442 AB - Although originally identified as mediators of inflammation, it is now apparent that chemokines play a fundamental role in tissue development. In this study, ELR(+)-CXC chemokine family members CXCL2 and CXCL7, along with their preferred receptor CXCR2, were expressed at the earliest stages of metanephric development in the rat, and signaling through this receptor was required for the survival and maintenance of the undifferentiated metanephric mesenchyme (MM). A specific antagonist of the CXCR2 receptor SB225002 induced apoptosis in this population but did not affect more mature structures or cells in the ureteric bud. CXCL7 treatment of isolated MM elicited an angiogenic response by upregulation of matrix metalloprotease 9 and endothelial and mesangial markers (platelet-endothelial cell adhesion molecule, Megsin, Thy-1, PDGF receptor alpha, and vascular alpha-actin) and induced SB225002-sensitive cell invasion through a matrix. Because Wilms' tumor cells may similarly depend on CXCR2 signaling for survival, primary tumor samples were analyzed, and 15 of 16 Wilms' tumors were found to be CXCR2 positive, whereas grossly normal kidney tissues from tumor patients or renal cell carcinomas were CXCR2 negative. Furthermore, cell lines derived from Wilms' tumors but not those from renal cell carcinomas were sensitive to SB225002-induced apoptosis. These data provide evidence for a prosurvival and proangiogenic role of ELR(+)-CXC chemokines and their receptor CXCR2 during metanephric development and suggest a novel mechanism for chemotherapeutic intervention in Wilms' tumor. JF - Journal of the American Society of Nephrology : JASN AU - Levashova, Zoia B AU - Sharma, Nirmala AU - Timofeeva, Olga A AU - Dome, Jeffrey S AU - Perantoni, Alan O AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute, National Institutes of Health, Frederick, MD 21702-1201, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 2359 EP - 2370 VL - 18 IS - 8 SN - 1046-6673, 1046-6673 KW - Chemokine CXCL1 KW - 0 KW - Chemokine CXCL2 KW - Chemokines, CXC KW - Cxcl1 protein, rat KW - Cxcl2 protein, rat KW - Cxcl7 protein, rat KW - Receptors, Interleukin-8A KW - Receptors, Interleukin-8B KW - Index Medicus KW - Animals KW - Oligonucleotide Array Sequence Analysis KW - Pregnancy KW - Rats KW - Signal Transduction -- physiology KW - Gene Expression Profiling KW - Rats, Inbred F344 KW - Cell Differentiation -- physiology KW - Kidney Neoplasms -- physiopathology KW - Cell Line KW - Cell Survival -- physiology KW - Female KW - Gene Expression Regulation, Developmental KW - Neovascularization, Physiologic -- physiology KW - Receptors, Interleukin-8A -- genetics KW - Chemokines, CXC -- metabolism KW - Receptors, Interleukin-8A -- metabolism KW - Receptors, Interleukin-8B -- genetics KW - Kidney -- embryology KW - Kidney -- physiology KW - Kidney -- cytology KW - Chemokines, CXC -- genetics KW - Receptors, Interleukin-8B -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70759080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.atitle=ELR%2B-CXC+chemokines+and+their+receptors+in+early+metanephric+development.&rft.au=Levashova%2C+Zoia+B%3BSharma%2C+Nirmala%3BTimofeeva%2C+Olga+A%3BDome%2C+Jeffrey+S%3BPerantoni%2C+Alan+O&rft.aulast=Levashova&rft.aufirst=Zoia&rft.date=2007-08-01&rft.volume=18&rft.issue=8&rft.spage=2359&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.issn=10466673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-26 N1 - Date created - 2007-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Darunavir: a second-generation protease inhibitor. AN - 70756461; 17646561 AB - The pharmacology, pharmacokinetics, drug interactions, clinical efficacy, adverse events, dosage and administration, and place in therapy of darunavir are reviewed. Darunavir is the most recent protease inhibitor (PI) to receive approved labeling from the Food and Drug Administration for the treatment of human immunodeficiency virus (HIV). Darunavir is unique among currently available PIs because it maintains antiretroviral activity against a variety of multidrug-resistant HIV strains. Darunavir is well absorbed, and the bioavailability of darunavir increases by 30% when given with food. Darunavir is approximately 95% bound to plasma proteins. Darunavir is metabolized by and inhibits cytochrome P-450 (CYP) isoenzyme 3A4; therefore, darunavir is prone to CYP3A4-mediated drug-drug interactions. Two trials have demonstrated the clinical efficacy of darunavir in HIV-positive patients previously treated with antiretrovirals. One trial demonstrated a 2 log(10) decrease in plasma HIV RNA levels, compared with a decrease of <1 log(10) in the control group. Average increases in CD4+ T-cell counts for darunavir and control groups were 124 and 20 cells/mm(3), respectively. Adverse events reported from preliminary safety data indicate that darunavir has a similar safety profile to other currently available PIs. The recommended adult dosage of darunavir is 600 mg (two tablets) combined with ritonavir 100 mg every 12 hours with food. Darunavir should be used with caution in patients with hepatic dysfunction. No dosage adjustment is necessary for patients with mild or moderate renal dysfunction. Darunavir is a new HIV PI that retains virological activity in the presence of multiple protease mutations. As such, darunavir appears to be a useful component of optimized combination antiretroviral therapy for HIV-infected patients previously treated with antiretrovirals. JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - Busse, Kristin H S AU - Penzak, Scott R AD - Pharmacy Department, Clinical Center, National Institutes of Health, Bethesda, MD 20896-1196, USA. bussek@mail.nih.gov Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 1593 EP - 1602 VL - 64 IS - 15 KW - HIV Protease Inhibitors KW - 0 KW - Sulfonamides KW - Darunavir KW - YO603Y8113 KW - Index Medicus KW - Animals KW - Drug Resistance, Viral KW - Humans KW - Clinical Trials as Topic KW - Sulfonamides -- pharmacokinetics KW - Sulfonamides -- adverse effects KW - Sulfonamides -- pharmacology KW - HIV Infections -- drug therapy KW - HIV Protease Inhibitors -- pharmacology KW - HIV Protease Inhibitors -- pharmacokinetics KW - HIV Protease Inhibitors -- therapeutic use KW - HIV Protease Inhibitors -- adverse effects KW - Sulfonamides -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70756461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Darunavir%3A+a+second-generation+protease+inhibitor.&rft.au=Busse%2C+Kristin+H+S%3BPenzak%2C+Scott+R&rft.aulast=Busse&rft.aufirst=Kristin+H&rft.date=2007-08-01&rft.volume=64&rft.issue=15&rft.spage=1593&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=1535-2900&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-21 N1 - Date created - 2007-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pathways to smoking cessation among African American and Puerto Rican young adults. AN - 70751821; 17600250 AB - We examined the pathways to smoking cessation between late adolescence and young adulthood. We obtained data from a sample of urban African American and Puerto Rican young adults (N=242), mean age 19 years, who reported tobacco use and determined cessation rates between late adolescence and young adulthood. We used structural equation modeling to examine the pathways of positive family relations, family smoking, maladaptive personality attributes, and substance use to smoking cessation. A mediational pathway linked the absence of positive family relations with maladaptive personality attributes, both of which were related to substance use and ultimately smoking cessation. Substance use mediated the path between family smoking and smoking cessation. The results suggest that a positive relationship with one's parents, less smoking in the family, conventional personality attributes, and little or no other substance use facilitate smoking cessation among young adults. JF - American journal of public health AU - Marcus, Stephen E AU - Pahl, Kerstin AU - Ning, Yuming AU - Brook, Judith S AD - National Cancer Institute, Washington, DC, USA. marcusst@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1444 EP - 1448 VL - 97 IS - 8 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Puerto Rico -- ethnology KW - Personality KW - Parent-Child Relations KW - Longitudinal Studies KW - Comorbidity KW - Factor Analysis, Statistical KW - New York City -- epidemiology KW - Risk Factors KW - Adult KW - Female KW - Male KW - Substance-Related Disorders -- epidemiology KW - Smoking Cessation -- psychology KW - Models, Psychological KW - Hispanic Americans -- statistics & numerical data KW - African Americans -- psychology KW - African Americans -- statistics & numerical data KW - Smoking Cessation -- methods KW - Hispanic Americans -- psychology KW - Smoking Cessation -- ethnology KW - Family Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70751821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Pathways+to+smoking+cessation+among+African+American+and+Puerto+Rican+young+adults.&rft.au=Marcus%2C+Stephen+E%3BPahl%2C+Kerstin%3BNing%2C+Yuming%3BBrook%2C+Judith+S&rft.aulast=Marcus&rft.aufirst=Stephen&rft.date=2007-08-01&rft.volume=97&rft.issue=8&rft.spage=1444&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=1541-0048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-20 N1 - Date created - 2007-07-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Addict Behav. 1999 Sep-Oct;24(5):673-7 [10574304] Addict Behav. 2006 May;31(5):788-801 [15993005] Nicotine Tob Res. 1999;1 Suppl 2:S51-7; discussion S69-70 [11768187] J Consult Clin Psychol. 2001 Dec;69(6):959-70 [11777123] Addict Behav. 2002 Mar-Apr;27(2):193-206 [11817762] Am J Health Promot. 2002 May-Jun;16(5):259-66 [12053437] Addiction. 2002 Jul;97(7):861-9 [12133125] Addiction. 2002 Dec;97(12):1537-50 [12472638] Nicotine Tob Res. 2003 Feb;5(1):85-98 [12745510] BMJ. 2004 Jun 26;328(7455):1519 [15213107] Behav Sci. 1974 Jan;19(1):1-15 [4808738] Am J Drug Alcohol Abuse. 1987;13(1-2):95-108 [3687887] Genet Soc Gen Psychol Monogr. 1990 May;116(2):111-267 [2376323] Prev Med. 1994 Jan;23(1):48-53 [8016032] Am J Public Health. 1996 Feb;86(2):214-20 [8633738] Addict Behav. 1996 May-Jun;21(3):291-302 [8883481] J Adolesc Health. 1997 Mar;20(3):226-31 [9069023] J Genet Psychol. 1997 Jun;158(2):172-88 [9168587] J Pers Soc Psychol. 1998 Feb;74(2):387-406 [9491584] Prev Med. 1998 May-Jun;27(3):365-84 [9612827] Am J Prev Med. 1999 Apr;16(3):202-7 [10198659] Addict Behav. 2005 Mar;30(3):517-29 [15718068] MMWR Morb Mortal Wkly Rep. 2005 Jul 1;54(25):625-8 [15988406] MMWR Morb Mortal Wkly Rep. 2005 Nov 11;54(44):1121-4 [16280969] Arch Gen Psychiatry. 2001 Sep;58(9):810-6 [11545662] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gemcitabine-based combinations for inoperable pancreatic cancer: have we made real progress? A meta-analysis of 20 phase 3 trials. AN - 70747759; 17577216 AB - Several attempts have been made at improving the efficacy of gemcitabine in advanced pancreatic cancer by combining it with other chemotherapeutic or molecularly targeted agents. However, randomized trials have produced conflicting results. All prospective, randomized, phase 3 trials that compared single-agent gemcitabine with gemcitabine-based combinations were considered eligible for the current analysis. A literature-based meta-analysis was performed, event-based relative risk ratios with 95% confidence intervals were derived through both a fixed-effect model approach and a random-effect model approach, and overall survival (OS) was explored as the primary endpoint. To estimate the magnitude of the eventual benefit, absolute differences and the number of patients needed to treat (NNT) for 1 patient to benefit were calculated. A sensitivity analysis for OS was performed according to the type of agent used in combination with gemcitabine. Twenty trials that involved 6,296 patients were identified. No significant differences in the primary endpoint were observed in the overall population or in the sensitivity analysis. Conversely, a significant advantage was evident with regard to both progression-free survival (PFS) and the overall response rate (ORR) in the overall population, with an absolute benefit of 2.6% (NTT = 39 patients) and 3.0% (NNT = 33 patients). Platinum combinations led to the greatest absolute benefits for PFS and ORR compared with single-agent gemcitabine (10% and 6.5%, respectively), but this did not result in an OS benefit. Improvement in PFS, but not in the ORR, was correlated with an improvement in OS. Single-agent gemcitabine remains the standard of care for patients with advanced pancreatic cancer. However, platinum/gemcitabine combinations appeared to improve PFS and the ORR and, thus, may be considered in selected patients. (c) 2007 American Cancer Society. JF - Cancer AU - Bria, Emilio AU - Milella, Michele AU - Gelibter, Alain AU - Cuppone, Federica AU - Pino, Maria Simona AU - Ruggeri, Enzo Maria AU - Carlini, Paolo AU - Nisticò, Cecilia AU - Terzoli, Edmondo AU - Cognetti, Francesco AU - Giannarelli, Diana AD - Department of Medical Oncology, Regina Elena National Cancer Institute, Rome, Italy. Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 525 EP - 533 VL - 110 IS - 3 SN - 0008-543X, 0008-543X KW - Antimetabolites, Antineoplastic KW - 0 KW - Deoxycytidine KW - 0W860991D6 KW - gemcitabine KW - B76N6SBZ8R KW - Abridged Index Medicus KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Prospective Studies KW - Survival Rate KW - Dose-Response Relationship, Drug KW - Clinical Trials, Phase III as Topic KW - Humans KW - Treatment Outcome KW - Disease Progression KW - Deoxycytidine -- analogs & derivatives KW - Deoxycytidine -- therapeutic use KW - Pancreatic Neoplasms -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Antimetabolites, Antineoplastic -- therapeutic use KW - Pancreatic Neoplasms -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70747759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Gemcitabine-based+combinations+for+inoperable+pancreatic+cancer%3A+have+we+made+real+progress%3F+A+meta-analysis+of+20+phase+3+trials.&rft.au=Bria%2C+Emilio%3BMilella%2C+Michele%3BGelibter%2C+Alain%3BCuppone%2C+Federica%3BPino%2C+Maria+Simona%3BRuggeri%2C+Enzo+Maria%3BCarlini%2C+Paolo%3BNistic%C3%B2%2C+Cecilia%3BTerzoli%2C+Edmondo%3BCognetti%2C+Francesco%3BGiannarelli%2C+Diana&rft.aulast=Bria&rft.aufirst=Emilio&rft.date=2007-08-01&rft.volume=110&rft.issue=3&rft.spage=525&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-06 N1 - Date created - 2007-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intersectin enhances huntingtin aggregation and neurodegeneration through activation of c-Jun-NH2-terminal kinase. AN - 70745663; 17550941 AB - Huntingon's disease is a progressive neurodegenerative disease arising from expansion of a polyglutamine (polyQ) tract in the protein huntingtin (Htt) resulting in aggregation of mutant Htt into nuclear and/or cytosolic inclusions in neurons. Mutant Htt affects multiple processes including protein degradation, transcription, signal transduction, fast axonal transport and endocytosis [reviewed in Ross, C.A. and Poirier, M.A. (2005) Opinion: what is the role of protein aggregation in neurodegeneration? Nat. Rev. Mol. Cell. Biol., 6, 891-898]. Here, we report that the endocytic and signal transduction scaffold intersectin (ITSN) increased aggregate formation by mutant Htt through activation of the c-Jun-NH(2)-terminal kinase (JNK)-MAPK pathway. Conversely, silencing ITSN or inhibiting JNK attenuated aggregate formation. Using a Drosophila model for polyQ repeat disease, we observed that ITSN enhanced polyQ-mediated neurotoxicity. A reciprocal relationship was observed between ITSN and Htt. While ITSN enhanced Htt aggregation and toxicity, Htt, in turn, inhibited the cooperativity between ITSN and the epidermal growth factor receptor signal transduction pathway. Finally, we observed that ITSN overexpression enhanced aggregation of polyQ-expanded androgen receptor (AR) as well as wild-type versions of both Htt and AR suggesting a broader involvement of ITSN in neurodegenerative diseases through destabilization of polyQ-containing proteins. JF - Human molecular genetics AU - Scappini, Erica AU - Koh, Tong-Wey AU - Martin, Negin P AU - O'Bryan, John P AD - Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 1862 EP - 1871 VL - 16 IS - 15 SN - 0964-6906, 0964-6906 KW - Adaptor Proteins, Vesicular Transport KW - 0 KW - HTT protein, human KW - Huntingtin Protein KW - Nerve Tissue Proteins KW - Nuclear Proteins KW - Peptides KW - Recombinant Fusion Proteins KW - intersectin 1 KW - polyglutamine KW - 26700-71-0 KW - JNK Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Microscopy, Confocal KW - Animals KW - Neurons -- metabolism KW - COS Cells KW - Enzyme Activation KW - Humans KW - Drosophila -- metabolism KW - Peptides -- metabolism KW - Mice KW - Recombinant Fusion Proteins -- metabolism KW - Cells, Cultured KW - Cercopithecus aethiops KW - Recombinant Fusion Proteins -- genetics KW - Drosophila -- genetics KW - Mutation KW - Signal Transduction KW - Nuclear Proteins -- analysis KW - Nerve Tissue Proteins -- analysis KW - Huntington Disease -- metabolism KW - Adaptor Proteins, Vesicular Transport -- metabolism KW - Nerve Tissue Proteins -- metabolism KW - Nuclear Proteins -- metabolism KW - JNK Mitogen-Activated Protein Kinases -- metabolism KW - Huntington Disease -- enzymology KW - Adaptor Proteins, Vesicular Transport -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70745663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+molecular+genetics&rft.atitle=Intersectin+enhances+huntingtin+aggregation+and+neurodegeneration+through+activation+of+c-Jun-NH2-terminal+kinase.&rft.au=Scappini%2C+Erica%3BKoh%2C+Tong-Wey%3BMartin%2C+Negin+P%3BO%27Bryan%2C+John+P&rft.aulast=Scappini&rft.aufirst=Erica&rft.date=2007-08-01&rft.volume=16&rft.issue=15&rft.spage=1862&rft.isbn=&rft.btitle=&rft.title=Human+molecular+genetics&rft.issn=09646906&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-18 N1 - Date created - 2007-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - CLIC4 mediates and is required for Ca2+-induced keratinocyte differentiation. AN - 70744835; 17636002 AB - Keratinocyte differentiation requires integrating signaling among intracellular ionic changes, kinase cascades, sequential gene expression, cell cycle arrest, and programmed cell death. We now show that Cl(-) intracellular channel 4 (CLIC4) expression is increased in both mouse and human keratinocytes undergoing differentiation induced by Ca(2+), serum and the protein kinase C (PKC)-activator, 12-O-tetradecanoyl-phorbol-13-acetate (TPA). Elevation of CLIC4 is associated with signaling by PKCdelta, and knockdown of CLIC4 protein by antisense or shRNA prevents Ca(2+)-induced keratin 1, keratin 10 and filaggrin expression and cell cycle arrest in differentiating keratinocytes. CLIC4 is cytoplasmic in actively proliferating keratinocytes in vitro, but the cytoplasmic CLIC4 translocates to the nucleus in keratinocytes undergoing growth arrest by differentiation, senescence or transforming growth factor beta (TGFbeta) treatment. Targeting CLIC4 to the nucleus of keratinocytes via adenoviral transduction increases nuclear Cl(-) content and enhances expression of differentiation markers in the absence of elevated Ca(2+). In vivo, CLIC4 is localized to the epidermis in mouse and human skin, where it is predominantly nuclear in quiescent cells. These results suggest that CLIC4 participates in epidermal homeostasis through both alterations in the level of expression and subcellular localization. Nuclear CLIC4, possibly by altering the Cl(-) and pH of the nucleus, contributes to cell cycle arrest and the specific gene expression program associated with keratinocyte terminal differentiation. JF - Journal of cell science AU - Suh, Kwang S AU - Mutoh, Michihiro AU - Mutoh, Tomoko AU - Li, Luowei AU - Ryscavage, Andrew AU - Crutchley, John M AU - Dumont, Rebecca A AU - Cheng, Christina AU - Yuspa, Stuart H AD - Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 2631 EP - 2640 VL - 120 SN - 0021-9533, 0021-9533 KW - CLIC4 protein, human KW - 0 KW - Chloride Channels KW - Intermediate Filament Proteins KW - Protein Isoforms KW - Transcription Factor AP-1 KW - filaggrin KW - Keratins KW - 68238-35-7 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Keratins -- metabolism KW - Animals KW - Transcription Factor AP-1 -- metabolism KW - Cells, Cultured KW - Cell Nucleus -- metabolism KW - Protein Isoforms -- metabolism KW - Humans KW - Gene Expression KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Mice KW - Intermediate Filament Proteins -- metabolism KW - Protein Kinase C -- metabolism KW - Calcium -- metabolism KW - Chloride Channels -- isolation & purification KW - Keratinocytes -- cytology KW - Chloride Channels -- metabolism KW - Cell Differentiation KW - Keratinocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70744835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cell+science&rft.atitle=CLIC4+mediates+and+is+required+for+Ca2%2B-induced+keratinocyte+differentiation.&rft.au=Suh%2C+Kwang+S%3BMutoh%2C+Michihiro%3BMutoh%2C+Tomoko%3BLi%2C+Luowei%3BRyscavage%2C+Andrew%3BCrutchley%2C+John+M%3BDumont%2C+Rebecca+A%3BCheng%2C+Christina%3BYuspa%2C+Stuart+H&rft.aulast=Suh&rft.aufirst=Kwang&rft.date=2007-08-01&rft.volume=120&rft.issue=&rft.spage=2631&rft.isbn=&rft.btitle=&rft.title=Journal+of+cell+science&rft.issn=00219533&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-06 N1 - Date created - 2007-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The anesthetic management of children with neonatal-onset multi-system inflammatory disease. AN - 70741850; 17646489 AB - Neonatal-onset multi-system inflammatory disease (NOMID), a rare autosomal dominantly inherited disease, belongs to a growing spectrum of autoinflammatory diseases, is characterized by urticarial rash, arthropathy, and chronic aseptic meningitis, and is associated with mutations in the cold-induced autoinflammatory gene, CIAS1, the gene that encodes the protein, cryopyrin. As little is known about the anesthetic considerations of the disease, we sought to identify the main features and respective anesthetic and perioperative implications of NOMID. We examined perianesthetic records of children with NOMID who were anesthetized for invasive diagnostic and therapeutic interventions between 2003 and 2006. In addition, we conducted an extensive literature review of the genetic, clinical, and biochemical abnormalities of the disease. Seventeen children with NOMID (median age 8 yr, range 9 mo to 11 yr) were anesthetized for diagnostic and therapeutic procedures. All patients had neurological involvement, including increased intracranial pressure, chronic aseptic meningitis, and developmental delay; 7 had bony overgrowth, 15 ocular, and 14 otological manifestations of NOMID. Despite the complexity of the disease, the perioperative course was uncomplicated, and no serious adverse events were observed. This study is the first to investigate the anesthetic implications of NOMID, an autoinflammatory disease associated with arthropathy, recurrent fevers, urticarial rash, and chronic aseptic meningitis. While for the pediatric anesthesiologist, the presence of fever and aseptic meningitis might make the conduct of anesthetics for elective procedures less desirable, our findings suggest that without evidence of active infection, even in the presence of fever and chronic aseptic meningitis, general and regional anesthesia may be conducted in patients with NOMID without untoward complications. JF - Anesthesia and analgesia AU - Lauro, Christine F AU - Goldbach-Mansky, Raphaela AU - Schmidt, Margaret AU - Quezado, Zenaide M N AD - Department of Anesthesia and Surgical Services, National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD 20892-1512, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 351 EP - 357 VL - 105 IS - 2 KW - Anesthetics KW - 0 KW - Carrier Proteins KW - NLR Family, Pyrin Domain-Containing 3 Protein KW - NLRP3 protein, human KW - Abridged Index Medicus KW - Index Medicus KW - Infant KW - Inflammation -- therapy KW - Inflammation -- physiopathology KW - Humans KW - Disease Management KW - Carrier Proteins -- genetics KW - Inflammation -- genetics KW - Child KW - Male KW - Female KW - Child, Preschool KW - Autoimmune Diseases of the Nervous System -- physiopathology KW - Anesthetics -- therapeutic use KW - Anesthetics -- adverse effects KW - Autoimmune Diseases of the Nervous System -- therapy KW - Autoimmune Diseases of the Nervous System -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70741850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesia+and+analgesia&rft.atitle=The+anesthetic+management+of+children+with+neonatal-onset+multi-system+inflammatory+disease.&rft.au=Lauro%2C+Christine+F%3BGoldbach-Mansky%2C+Raphaela%3BSchmidt%2C+Margaret%3BQuezado%2C+Zenaide+M+N&rft.aulast=Lauro&rft.aufirst=Christine&rft.date=2007-08-01&rft.volume=105&rft.issue=2&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=Anesthesia+and+analgesia&rft.issn=1526-7598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-20 N1 - Date created - 2007-07-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arthritis Rheum. 2005 Apr;52(4):1283-6 [15818707] Clin Ther. 2004 Dec;26(12):1960-75 [15823761] Arch Dermatol. 2005 Feb;141(2):248-53 [15724022] Immunobiology. 1990 Jun;180(4-5):316-27 [2168857] J Clin Invest. 1990 May;85(5):1694-7 [2139669] Scand J Rheumatol Suppl. 1987;66:57-68 [3482735] Pediatrics. 2004 Jul;114(1):e124-7 [15231984] Blood. 2004 Apr 1;103(7):2809-15 [14630794] Immunity. 2004 Mar;20(3):319-25 [15030775] Eur J Haematol. 2003 Sep;71(3):215-9 [12930324] Curr Opin Rheumatol. 2003 Jan;15(1):61-9 [12496512] Arthritis Rheum. 2002 Dec;46(12):3340-8 [12483741] Acta Neurochir Suppl. 2002;81:89-91 [12168367] Am J Hum Genet. 2002 Jul;71(1):198-203 [12032915] Clin Exp Rheumatol. 2001 Jan-Feb;19(1):103-6 [11247311] Nat Rev Immunol. 2007 Jan;7(1):31-40 [17186029] N Engl J Med. 2006 Aug 10;355(6):581-92 [16899778] Reg Anesth Pain Med. 2006 Jul-Aug;31(4):334-45 [16857553] Reg Anesth Pain Med. 2006 Jul-Aug;31(4):324-33 [16857552] Am J Med Genet A. 2006 Apr 15;140(8):883-6 [16532456] Nature. 2006 Mar 9;440(7081):228-32 [16407890] Paediatr Anaesth. 2005 Dec;15(12):1078-82 [16324027] Scand J Rheumatol. 2005 May-Jun;34(3):246-9 [16134734] Curr Opin Rheumatol. 2005 Sep;17(5):586-99 [16093838] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reporting data from high-throughput screening of small-molecule libraries. AN - 70736539; 17637769 AB - Publications reporting results of small-molecule screens are becoming more common as academic researchers increasingly make use of high-throughput screening (HTS) facilities. However, no standards have been formally established for reporting small-molecule screening data, and often key information important for the evaluation and interpretation of results is omitted in published HTS protocols. Here, we propose concise guidelines for reporting small-molecule HTS data. JF - Nature chemical biology AU - Inglese, James AU - Shamu, Caroline E AU - Guy, R Kiplin AD - US National Institutes of Health Chemical Genomics Center, National Human Genome Institute, National Institutes of Health, 9800 Medical Center Drive, Bethesda, Maryland 20892-3370, USA. jinglese@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 438 EP - 441 VL - 3 IS - 8 SN - 1552-4450, 1552-4450 KW - Pharmaceutical Preparations KW - 0 KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Models, Chemical KW - Guidelines as Topic KW - Molecular Conformation KW - Inhibitory Concentration 50 KW - Drug Evaluation, Preclinical KW - Drug Design KW - Technology, Pharmaceutical -- methods KW - Combinatorial Chemistry Techniques KW - Chemistry, Pharmaceutical -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70736539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+chemical+biology&rft.atitle=Reporting+data+from+high-throughput+screening+of+small-molecule+libraries.&rft.au=Inglese%2C+James%3BShamu%2C+Caroline+E%3BGuy%2C+R+Kiplin&rft.aulast=Inglese&rft.aufirst=James&rft.date=2007-08-01&rft.volume=3&rft.issue=8&rft.spage=438&rft.isbn=&rft.btitle=&rft.title=Nature+chemical+biology&rft.issn=15524450&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-06 N1 - Date created - 2007-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification of two distinct human immunodeficiency virus type 1 Vif determinants critical for interactions with human APOBEC3G and APOBEC3F. AN - 70726759; 17522216 AB - Human cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) inhibit replication of Vif-deficient human immunodeficiency virus type 1 (HIV-1). HIV-1 Vif overcomes these host restriction factors by binding to them and inducing their proteasomal degradation. The Vif-A3G and Vif-A3F interactions are attractive targets for antiviral drug development because inhibiting the interactions could allow the host defense mechanism to control HIV-1 replication. It was recently reported that the Vif amino acids D(14)RMR(17) are important for functional interaction and degradation of the previously identified Vif-resistant mutant of A3G (D128K-A3G). However, the Vif determinants important for functional interaction with A3G and A3F have not been fully characterized. To identify these determinants, we performed an extensive mutational analysis of HIV-1 Vif. Our analysis revealed two distinct Vif determinants, amino acids Y(40)RHHY(44) and D(14)RMR(17), which are essential for binding to A3G and A3F, respectively. Interestingly, mutation of the A3G-binding region increased Vif's ability to suppress A3F. Vif binding to D128K-A3G was also dependent on the Y(40)RHHY(44) region but not the D(14)RMR(17) region. Consistent with previous observations, subsequent neutralization of the D128K-A3G antiviral activity required substitution of Vif determinant D(14)RMR(17) with SEMQ, similar to the SERQ amino acids in simian immunodeficiency virus SIV(AGM) Vif, which is capable of neutralizing D128K-A3G. These studies are the first to clearly identify two distinct regions of Vif that are critical for independent interactions with A3G and A3F. Pharmacological interference with the Vif-A3G or Vif-A3F interactions could result in potent inhibition of HIV-1 replication by the APOBEC3 proteins. JF - Journal of virology AU - Russell, Rebecca A AU - Pathak, Vinay K AD - HIV Drug Resistance Program, National Cancer Institute-Frederick, P.O. Box B, Bldg. 535, Rm. 334, Frederick, MD 21702-1201, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 8201 EP - 8210 VL - 81 IS - 15 SN - 0022-538X, 0022-538X KW - Gene Products, vif KW - 0 KW - Repressor Proteins KW - vif Gene Products, Human Immunodeficiency Virus KW - Nucleoside Deaminases KW - EC 3.5.4.- KW - APOBEC3F protein, human KW - EC 3.5.4.1 KW - Cytosine Deaminase KW - APOBEC-3G Deaminase KW - EC 3.5.4.5 KW - APOBEC3G protein, human KW - Cytidine Deaminase KW - Alanine KW - OF5P57N2ZX KW - Index Medicus KW - Alanine -- metabolism KW - Humans KW - DNA Mutational Analysis KW - Protein Binding KW - Cell Line KW - Mutagenesis KW - Nucleoside Deaminases -- genetics KW - HIV-1 -- metabolism KW - Nucleoside Deaminases -- antagonists & inhibitors KW - Gene Products, vif -- chemistry KW - Cytosine Deaminase -- antagonists & inhibitors KW - Repressor Proteins -- metabolism KW - Nucleoside Deaminases -- metabolism KW - Cytosine Deaminase -- genetics KW - Gene Products, vif -- metabolism KW - Cytosine Deaminase -- metabolism KW - Gene Products, vif -- genetics KW - Repressor Proteins -- genetics KW - Repressor Proteins -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70726759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Identification+of+two+distinct+human+immunodeficiency+virus+type+1+Vif+determinants+critical+for+interactions+with+human+APOBEC3G+and+APOBEC3F.&rft.au=Russell%2C+Rebecca+A%3BPathak%2C+Vinay+K&rft.aulast=Russell&rft.aufirst=Rebecca&rft.date=2007-08-01&rft.volume=81&rft.issue=15&rft.spage=8201&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-26 N1 - Date created - 2007-07-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3927-32 [14978281] Virology. 2007 Apr 10;360(2):247-56 [17126871] J Biol Chem. 2004 Apr 9;279(15):14481-3 [14966139] Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5652-7 [15054139] EMBO J. 2004 Jun 16;23(12):2451-8 [15152192] Curr Biol. 2004 Aug 10;14(15):1385-91 [15296757] J Biol Chem. 2004 Aug 20;279(34):35822-8 [15210704] Nature. 1987 Aug 20-26;328(6132):728-30 [2441266] J Virol. 1992 Nov;66(11):6489-95 [1357189] J Virol. 1993 Aug;67(8):4945-55 [8331734] J Virol. 1994 Feb;68(2):704-12 [8289374] Methods Cell Biol. 1994;43 Pt A:99-112 [7823872] J Virol. 1998 Dec;72(12):10251-5 [9811770] Nat Med. 1998 Dec;4(12):1397-400 [9846577] Hum Gene Ther. 1999 Jan 1;10(1):123-32 [10022537] J Virol. 2000 Sep;74(18):8358-67 [10954535] Antimicrob Agents Chemother. 2002 Jun;46(6):1896-905 [12019106] Nature. 2002 Aug 8;418(6898):646-50 [12167863] J Virol. 2003 Jan;77(2):1626-32 [12502880] Science. 2003 May 16;300(5622):1112 [12750511] Cell. 2003 Jun 13;113(6):803-9 [12809610] Nature. 2003 Jul 3;424(6944):94-8 [12808465] Nature. 2003 Jul 3;424(6944):99-103 [12808466] Mol Cell. 2003 Sep;12(3):591-601 [14527406] J Virol. 2003 Nov;77(21):11398-407 [14557625] Nat Med. 2003 Nov;9(11):1404-7 [14528300] Nat Med. 2003 Nov;9(11):1398-403 [14528301] Science. 2003 Nov 7;302(5647):1056-60 [14564014] Curr Biol. 2003 Nov 11;13(22):2009-13 [14614829] J Virol. 2004 Feb;78(4):2072-81 [14747572] J Biol Chem. 2004 Feb 27;279(9):7792-8 [14672928] Virology. 2004 Feb 20;319(2):163-75 [15015498] J Virol. 1999 Apr;73(4):2675-81 [10074113] J Exp Med. 1999 Jun 7;189(11):1735-46 [10359577] Biochem Biophys Res Commun. 2005 Apr 15;329(3):917-24 [15752743] J Biol Chem. 2005 May 13;280(19):18573-8 [15781449] Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11444-9 [16076960] J Virol. 2006 Mar;80(6):3112-5 [16501124] Virology. 2006 May 25;349(1):31-40 [16460778] J Virol. 2006 Jun;80(12):5984-91 [16731937] FASEB J. 2007 Jan;21(1):217-22 [17135358] Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3770-4 [14999100] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Arachidonic acid metabolism in brain physiology and pathology: lessons from genetically altered mouse models. AN - 70723752; 17403135 AB - The arachidonic acid (AA) cascade involves the release of AA from the membrane phospholipids by a phospholipase A(2), followed by its subsequent metabolism to bioactive prostanoids by cyclooxygenases coupled with terminal synthases. Altered brain AA metabolism has been implicated in neurological, neurodegenerative, and psychiatric disorders. The development of genetically altered mice lacking specific enzymes of the AA cascade has helped to elucidate the individual roles of these enzymes in brain physiology and pathology. The roles of AA and its metabolites in brain physiology, with a particular emphasis on the phospholipase A(2)/cyclooxygenases pathway, are summarized, and the specific phenotypes of genetically altered mice relevant to brain physiology and neurotoxic models are discussed. JF - Journal of neurochemistry AU - Bosetti, Francesca AD - Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA. frances@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 577 EP - 586 VL - 102 IS - 3 SN - 0022-3042, 0022-3042 KW - Prostaglandins KW - 0 KW - Arachidonic Acid KW - 27YG812J1I KW - Prostaglandin-Endoperoxide Synthases KW - EC 1.14.99.1 KW - Phospholipases A KW - EC 3.1.1.32 KW - Index Medicus KW - Animals KW - Mice, Knockout -- genetics KW - Brain Diseases -- genetics KW - Prostaglandins -- biosynthesis KW - Mice, Knockout -- metabolism KW - Mice KW - Brain Diseases -- physiopathology KW - Models, Biological KW - Brain Diseases -- metabolism KW - Brain -- physiopathology KW - Prostaglandin-Endoperoxide Synthases -- metabolism KW - Brain -- metabolism KW - Arachidonic Acid -- metabolism KW - Phospholipases A -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70723752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Arachidonic+acid+metabolism+in+brain+physiology+and+pathology%3A+lessons+from+genetically+altered+mouse+models.&rft.au=Bosetti%2C+Francesca&rft.aulast=Bosetti&rft.aufirst=Francesca&rft.date=2007-08-01&rft.volume=102&rft.issue=3&rft.spage=577&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-15 N1 - Date created - 2007-07-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Brain Res. 2003 Jan 10;959(2):328-35 [12493622] J Lipid Res. 2003 Jan;44(1):109-17 [12518029] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4132-7 [12642666] J Neurochem. 2003 May;85(3):690-6 [12694395] Comp Med. 2004 Oct;54(5):497-513 [15575363] J Neurochem. 2004 Dec;91(6):1389-97 [15584915] Brain Res. 2005 Mar 10;1037(1-2):180-6 [15777767] Ann Neurol. 2005 May;57(5):758-61 [15852374] Am J Physiol Regul Integr Comp Physiol. 2005 Jun;288(6):R1774-82 [15718387] J Neuroimmunol. 2005 Sep;166(1-2):55-64 [16019083] Glia. 2005 Oct;52(1):70-7 [15920732] J Neurochem. 2005 Sep;94(6):1546-58 [16000148] Brain Res Mol Brain Res. 2005 Oct 3;139(2):217-24 [16055227] Am J Pathol. 2005 Nov;167(5):1371-7 [16251421] Eur J Neurosci. 2005 Nov;22(9):2199-206 [16262658] Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16066-71 [16247016] Ann Neurol. 2001 Feb;49(2):176-85 [11220737] J Neurochem. 2005 Dec;95(6):1563-74 [16277613] J Neurochem. 2006 Feb;96(3):669-79 [16405503] Nat Med. 2006 Feb;12(2):225-9 [16432513] Mol Nutr Food Res. 2006 Apr;50(4-5):451-5 [16534751] J Neurosci. 2006 Apr 19;26(16):4383-93 [16624958] Proc Natl Acad Sci U S A. 2001 Jan 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2017-01-18 ER - TY - JOUR T1 - Medication-related impulse control and repetitive behaviors in Parkinson's disease. AN - 70713942; 17620886 AB - A range of impulse control and repetitive behaviors presumed to be related to dopaminergic medications has been recognized in Parkinson's disease. These behaviors are linked by their incentive or reward-based and repetitive natures and overlap with addictions. The behaviors include pathological gambling, hypersexuality, compulsive shopping, and compulsive eating and are related to punding and compulsive medication use. In patients on dopamine agonists, these behaviors as a group are relatively common, can have potentially devastating psychosocial consequences and are commonly hidden. Recent studies have investigated prevalence rates and associated factors. The literature on these behaviors in Parkinson's disease, including definitions, epidemiology, pathophysiology and management, is reviewed. The relationship to medications, Parkinson's disease and individual susceptibility is examined. These behaviors can affect up to 14% of Parkinson's disease patients on dopamine agonists. Clinicians should warn patients prior to initiating dopamine agonists and enquire about these behaviors during follow up. JF - Current opinion in neurology AU - Voon, Valerie AU - Potenza, Marc N AU - Thomsen, Teri AD - Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, Maryland 20892-1428, USA. voonv@ninds.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 484 EP - 492 VL - 20 IS - 4 SN - 1350-7540, 1350-7540 KW - Antiparkinson Agents KW - 0 KW - Dopamine Agonists KW - Receptors, Dopamine KW - Index Medicus KW - Reward KW - Humans KW - Neuronal Plasticity -- physiology KW - Receptors, Dopamine -- metabolism KW - Disruptive, Impulse Control, and Conduct Disorders -- epidemiology KW - Disruptive, Impulse Control, and Conduct Disorders -- chemically induced KW - Antiparkinson Agents -- adverse effects KW - Disruptive, Impulse Control, and Conduct Disorders -- physiopathology KW - Stereotyped Behavior KW - Compulsive Behavior -- chemically induced KW - Parkinson Disease -- complications KW - Dopamine Agonists -- adverse effects KW - Parkinson Disease -- physiopathology KW - Parkinson Disease -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70713942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+neurology&rft.atitle=Medication-related+impulse+control+and+repetitive+behaviors+in+Parkinson%27s+disease.&rft.au=Voon%2C+Valerie%3BPotenza%2C+Marc+N%3BThomsen%2C+Teri&rft.aulast=Voon&rft.aufirst=Valerie&rft.date=2007-08-01&rft.volume=20&rft.issue=4&rft.spage=484&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+neurology&rft.issn=13507540&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-27 N1 - Date created - 2007-07-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of simian virus-40 as a biological prognostic factor in Egyptian patients with malignant pleural mesothelioma. AN - 70704867; 17610473 AB - The association between simian virus (SV40) and malignant pleural mesothelioma (MPM) suggests an etiological role for SV40. However, exact pathogenetic mechanisms and possible prognostic value are not clear. The purpose of the present paper was to investigate 40 Egyptian MPM patients for the presence of SV40 DNA, altered Rb expression and p53 gene status using immunohistochemistry and molecular techniques. The relation between SV40, asbestos exposure, Rb, p53 and their contribution to the overall survival (OS) were also assessed. SV40 DNA was detected in 20/40 patients and asbestos exposure in 31 patients; 18 of them were SV40 positive. Altered p53 and Rb expression were detected in 57.5% and 52.5%, respectively, with no p53 mutation. Univariate analysis showed a significant correlation between OS and stage (P = 0.03), performance status (P = 0.04), p53 overexpression (P = 0.05), asbestos exposure (P = 0.002) and SV40 (P = 0.001). Multivariate analysis showed that when SV40 and asbestos exposure were considered together, only combined positivity of both was an independent prognostic factor affecting the OS (P = 0.001). SV40 and asbestos exposure are common in Egyptian MPM, denoting a possible etiological role and a synergistic effect for both agents. Combined positivity for SV40 and asbestos exposure is an independent prognostic factor in MPM, having a detrimental effect on OS. JF - Pathology international AU - Zekri, Abdel-Rahman N AU - Bahnassy, Abeer A AU - Mohamed, Waleed S AU - Hassan, Nelly AU - Abdel-Rahman, Abdel-Rahman M AU - El-Kassem, Fatma Abou AU - Gaafar, Rabab AD - Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt. ncizakri@starnet.com.eg Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 493 EP - 501 VL - 57 IS - 8 SN - 1320-5463, 1320-5463 KW - DNA, Viral KW - 0 KW - Retinoblastoma Protein KW - Tumor Suppressor Protein p53 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Asbestos -- poisoning KW - Fluorescent Antibody Technique, Indirect KW - Humans KW - Prognosis KW - Tumor Suppressor Protein p53 -- metabolism KW - Gene Expression Regulation, Neoplastic KW - Prospective Studies KW - Survival Rate KW - DNA, Viral -- analysis KW - Egypt -- epidemiology KW - Adult KW - Retinoblastoma Protein -- metabolism KW - Middle Aged KW - Tumor Suppressor Protein p53 -- genetics KW - Environmental Exposure -- adverse effects KW - Female KW - Male KW - Tumor Virus Infections -- virology KW - Simian virus 40 -- isolation & purification KW - Simian virus 40 -- genetics KW - Polyomavirus Infections -- pathology KW - Pleural Neoplasms -- mortality KW - Polyomavirus Infections -- virology KW - Pleural Neoplasms -- virology KW - Tumor Virus Infections -- pathology KW - Pleural Neoplasms -- pathology KW - Mesothelioma -- mortality KW - Mesothelioma -- pathology KW - Mesothelioma -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70704867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pathology+international&rft.atitle=Evaluation+of+simian+virus-40+as+a+biological+prognostic+factor+in+Egyptian+patients+with+malignant+pleural+mesothelioma.&rft.au=Zekri%2C+Abdel-Rahman+N%3BBahnassy%2C+Abeer+A%3BMohamed%2C+Waleed+S%3BHassan%2C+Nelly%3BAbdel-Rahman%2C+Abdel-Rahman+M%3BEl-Kassem%2C+Fatma+Abou%3BGaafar%2C+Rabab&rft.aulast=Zekri&rft.aufirst=Abdel-Rahman&rft.date=2007-08-01&rft.volume=57&rft.issue=8&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Pathology+international&rft.issn=13205463&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-20 N1 - Date created - 2007-07-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Stress-induced relapse to cocaine seeking: roles for the CRF(2) receptor and CRF-binding protein in the ventral tegmental area of the rat. AN - 70677169; 17437087 AB - Footshock reinstates cocaine seeking in cocaine-experienced rats by inducing corticotropin-releasing factor (CRF) and glutamate release in the ventral tegmental area (VTA) and thus activating VTA dopaminergic neurons. Footshock-induced VTA glutamate release, dopamine activation and reinstatements are blocked by VTA administration of a alpha-helical CRF, a nonselective CRF receptor antagonist. The effects of selective CRF antagonists have not yet been reported. The present studies were designed to explore the roles of VTA CRF receptor subtypes and CRF-BP in these effects induced by footshock. Rats were first trained to lever-press for intravenous cocaine (1 mg/infusion/0.13 ml, FR-1 schedule), and then tested under extinction conditions until response rates returned to the pretraining baseline. Reinstatements, VTA glutamate and dopamine levels [microdialysis with high performance liquid chromatography (HPLC)] were then assessed, under various pharmacological conditions, after mild inescapable footshock. Footshock-induced reinstatement of cocaine seeking and release of VTA glutamate and dopamine were blocked by selective blockade of VTA CRF(2) receptors (CRF(2)Rs) but not CRF(1)Rs. VTA perfusion of CRF or CRF(2)R agonists that have strong affinity for CRF-BP mimicked the effects induced by footshock while CRFR agonists that do not bind CRF-BP were ineffective. CRF(6-33), which competes for the CRF binding site on CRF-BP, attenuated the effects of CRF or urocortin I on VTA glutamate and dopamine release and on reinstatement of cocaine seeking. The present studies revealed a role of VTA CRF-BP and suggest an involvement of CRF(2)R in the effectiveness of stress in triggering glutamate and dopamine release and cocaine seeking in drug-experienced animals. JF - Psychopharmacology AU - Wang, Bin AU - You, Zhi-Bing AU - Rice, Kenner C AU - Wise, Roy A AD - Behavioral Neuroscience Branch, Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 283 EP - 294 VL - 193 IS - 2 SN - 0033-3158, 0033-3158 KW - CRF receptor type 1 KW - 0 KW - CRF receptor type 2 KW - Carrier Proteins KW - Receptors, Corticotropin-Releasing Hormone KW - alpha helical corticotropin-releasing hormone KW - corticotropin releasing factor-binding protein KW - 134773-81-2 KW - Glutamic Acid KW - 3KX376GY7L KW - Corticotropin-Releasing Hormone KW - 9015-71-8 KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Conditioning, Operant -- drug effects KW - Animals KW - Glutamic Acid -- metabolism KW - Rats, Long-Evans KW - Dopamine -- metabolism KW - Cocaine -- administration & dosage KW - Protein Binding KW - Recurrence KW - Rats KW - Behavior, Animal -- drug effects KW - Self Administration KW - Cocaine -- pharmacology KW - Electroshock KW - Male KW - Carrier Proteins -- metabolism KW - Receptors, Corticotropin-Releasing Hormone -- metabolism KW - Cocaine-Related Disorders -- psychology KW - Corticotropin-Releasing Hormone -- antagonists & inhibitors KW - Cocaine-Related Disorders -- physiopathology KW - Ventral Tegmental Area -- metabolism KW - Receptors, Corticotropin-Releasing Hormone -- antagonists & inhibitors KW - Corticotropin-Releasing Hormone -- agonists KW - Cocaine-Related Disorders -- etiology KW - Corticotropin-Releasing Hormone -- pharmacology KW - Corticotropin-Releasing Hormone -- metabolism KW - Stress, Psychological -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70677169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Stress-induced+relapse+to+cocaine+seeking%3A+roles+for+the+CRF%282%29+receptor+and+CRF-binding+protein+in+the+ventral+tegmental+area+of+the+rat.&rft.au=Wang%2C+Bin%3BYou%2C+Zhi-Bing%3BRice%2C+Kenner+C%3BWise%2C+Roy+A&rft.aulast=Wang&rft.aufirst=Bin&rft.date=2007-08-01&rft.volume=193&rft.issue=2&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-20 N1 - Date created - 2007-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Oligodendroglial abnormalities in schizophrenia, mood disorders and substance abuse. Comorbidity, shared traits, or molecular phenocopies? AN - 70656322; 17291372 AB - The evidence implicating oligodendroglia in major mental disorders has grown significantly in the past few years. Microarray analysis revealed altered expression of oligodendroglia-related genes in multiple brain regions from several, clinically diverse groups of subjects with schizophrenia (SZ) as well as subjects with bipolar disorder (BD) and major depressive disorders (MDD), alcoholics and cocaine users. In line with gene expression findings, evidence for ultrastructural changes in white matter and altered oligodendroglia in these disorders were reported in neuroimaging and neuropathological studies. Changes in oligodendroglia-related genes reported in SZ, BD and MDD appear to display considerable similarities (particularly decreased expression of MAG, ERBB, TF, PLP1, MOG, MOBP, MOG), while changes in cocaine abuse and alcoholism are more diverse. Common oligodendroglial abnormalities might indicate aetiological or pathophysiological overlaps between different disorders. The possible mechanisms of oligodendroglial abnormalities may involve functional variations in oligodendroglia-related genes, epigenetic regulation of chromatin, DA system hyperactivity and other mechanisms. JF - The international journal of neuropsychopharmacology AU - Sokolov, Boris P AD - Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD, USA. BSokolov@intra.nida.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 547 EP - 555 VL - 10 IS - 4 SN - 1461-1457, 1461-1457 KW - Nerve Tissue Proteins KW - 0 KW - Index Medicus KW - Phenotype KW - Humans KW - Nerve Tissue Proteins -- metabolism KW - Gene Expression Regulation KW - Myelin Sheath -- metabolism KW - Genetic Predisposition to Disease KW - Nerve Tissue Proteins -- genetics KW - Epigenesis, Genetic KW - Comorbidity KW - Oligodendroglia -- pathology KW - Alcoholism -- pathology KW - Schizophrenia -- metabolism KW - Alcoholism -- metabolism KW - Schizophrenia -- pathology KW - Alcoholism -- genetics KW - Mood Disorders -- genetics KW - Mood Disorders -- pathology KW - Oligodendroglia -- metabolism KW - Cocaine-Related Disorders -- genetics KW - Cocaine-Related Disorders -- pathology KW - Schizophrenia -- genetics KW - Cocaine-Related Disorders -- metabolism KW - Mood Disorders -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70656322?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+international+journal+of+neuropsychopharmacology&rft.atitle=Oligodendroglial+abnormalities+in+schizophrenia%2C+mood+disorders+and+substance+abuse.+Comorbidity%2C+shared+traits%2C+or+molecular+phenocopies%3F&rft.au=Sokolov%2C+Boris+P&rft.aulast=Sokolov&rft.aufirst=Boris&rft.date=2007-08-01&rft.volume=10&rft.issue=4&rft.spage=547&rft.isbn=&rft.btitle=&rft.title=The+international+journal+of+neuropsychopharmacology&rft.issn=14611457&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-18 N1 - Date created - 2007-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Therapy for metastatic ESFT: is it time to ask new questions? AN - 70614716; 17474114 JF - Pediatric blood & cancer AU - Snyder, Kristen M AU - Mackall, Crystal L AD - Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 115 EP - 116 VL - 49 IS - 2 SN - 1545-5009, 1545-5009 KW - Antineoplastic Agents, Alkylating KW - 0 KW - Index Medicus KW - Neuroectodermal Tumors, Primitive -- secondary KW - Multicenter Studies as Topic KW - Neuroectodermal Tumors, Primitive -- drug therapy KW - Combined Modality Therapy KW - Humans KW - Treatment Outcome KW - Clinical Trials as Topic KW - Pilot Projects KW - Bone Neoplasms -- pathology KW - Transplantation, Autologous KW - Neuroectodermal Tumors, Primitive -- surgery KW - Antineoplastic Agents, Alkylating -- therapeutic use KW - Peripheral Blood Stem Cell Transplantation KW - Sarcoma, Ewing -- secondary KW - Sarcoma, Ewing -- surgery KW - Antineoplastic Agents, Alkylating -- administration & dosage KW - Sarcoma, Ewing -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70614716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+blood+%26+cancer&rft.atitle=Therapy+for+metastatic+ESFT%3A+is+it+time+to+ask+new+questions%3F&rft.au=Snyder%2C+Kristen+M%3BMackall%2C+Crystal+L&rft.aulast=Snyder&rft.aufirst=Kristen&rft.date=2007-08-01&rft.volume=49&rft.issue=2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Pediatric+blood+%26+cancer&rft.issn=15455009&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-24 N1 - Date created - 2007-06-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Pediatr Blood Cancer. 2007 Aug;49(2):196-8 [17417796] Pediatr Blood Cancer. 2007 Aug;49(2):190-5 [17262797] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Teratogenicity risk of antiretroviral therapy in pregnancy. AN - 68303082; 17883999 AB - Highly active antiretroviral regimens are recommended for use in pregnancy to prevent vertical transmission of HIV, and many women enter pregnancy already on these regimens for their own health. Sources of data on the potential teratogenicity of antiretroviral drugs include animal studies, cohort studies, the Antiretroviral Pregnancy Registry, and case reports, but data on newly approved drugs are often limited. Thus far, concerns have been identified regarding a potential association between first trimester efavirenz exposure and neural tube defects based on a study in monkeys and case reports in humans, a possible association between first trimester exposure to zidovudine and an increased risk of hypospadias based on one cohort study, and an increased risk of septal heart defects in animals with delavirdine. Additional data on risks of antiretrovirals during pregnancy are needed. Providers should report cases of antiretroviral drug exposures during pregnancy to the Antiretroviral Pregnancy Registry. JF - Current HIV/AIDS reports AU - Watts, D Heather AD - Pediatric, Adolescent, and Maternal AIDS Branch, CRMC/NICHD/NIH, 6100 Executive Boulevard, Room 4B11, Bethesda, MD 20892, USA. hw59i@nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 135 EP - 140 VL - 4 IS - 3 SN - 1548-3568, 1548-3568 KW - Anti-Retroviral Agents KW - 0 KW - Teratogens KW - Index Medicus KW - Animals KW - Risk Factors KW - Humans KW - Infant, Newborn KW - Female KW - Pregnancy KW - Infectious Disease Transmission, Vertical -- prevention & control KW - HIV Infections -- transmission KW - HIV Infections -- prevention & control KW - Anti-Retroviral Agents -- adverse effects KW - Abnormalities, Drug-Induced -- etiology KW - Anti-Retroviral Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68303082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+HIV%2FAIDS+reports&rft.atitle=Teratogenicity+risk+of+antiretroviral+therapy+in+pregnancy.&rft.au=Watts%2C+D+Heather&rft.aulast=Watts&rft.aufirst=D&rft.date=2007-08-01&rft.volume=4&rft.issue=3&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Current+HIV%2FAIDS+reports&rft.issn=15483568&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-05 N1 - Date created - 2007-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Excess lifetime cancer mortality risk attributable to radiation exposure from computed tomography examinations in children. AN - 68285609; 17877063 AB - The use of computed tomography in Israel has been growing rapidly during recent decades. The major drawback of this important technology is the exposure to ionizing radiation, especially among children who have increased organ radiosensitivity and a long lifetime to potentially develop radiation-related cancer. To estimate the number of excess lifetime cancer deaths related to annual CT scans performed in children in Israel. We used CT scan utilization data from 1999 to 2003 obtained from the second largest health management organization in the country to project age and gender-specific CT scan use nationwide. Based on published organ doses for common CT examinations and radiation-related cancer mortality risk estimates from studies in survivors of the atomic bomb, we estimated the excess lifetime risks for cancer mortality attributed to use of CT in children and adolescents (up to 18 years old) in Israel. We estimated that 17,686 pediatric scans were conducted annually in Israel during 1999-2003. We project that 9.5 lifetime deaths would be associated with 1 year of pediatric CT scanning. This number represents an excess of 0.29% over the total number of patients who are eventually estimated to die from cancer in their lifetime. Pediatric CT scans in Israel may result in a small but not negligible increased lifetime risk for cancer mortality. Because of the uncertainty regarding radiation effects at low doses, our estimates of CT-related cancer mortality should be considered with caution. Nevertheless, physicians, CT technologists, and health authorities should work together to minimize the radiation dose for children to as low as reasonably achievable and encourage responsible use of this essential diagnostic tool. JF - The Israel Medical Association journal : IMAJ AU - Chodick, Gabriel AU - Ronckers, Cécile M AU - Shalev, Varda AU - Ron, Elaine AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892-7238, USA. hodik_g@mac.org.il Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 584 EP - 587 VL - 9 IS - 8 SN - 1565-1088, 1565-1088 KW - Index Medicus KW - Infant KW - Radiation Dosage KW - Humans KW - Child KW - Adolescent KW - Stomach -- diagnostic imaging KW - Brain -- diagnostic imaging KW - Male KW - Female KW - Survival Analysis KW - Risk Assessment KW - Child, Preschool KW - Tomography, X-Ray Computed -- adverse effects KW - Neoplasms, Radiation-Induced -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68285609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Israel+Medical+Association+journal+%3A+IMAJ&rft.atitle=Excess+lifetime+cancer+mortality+risk+attributable+to+radiation+exposure+from+computed+tomography+examinations+in+children.&rft.au=Chodick%2C+Gabriel%3BRonckers%2C+C%C3%A9cile+M%3BShalev%2C+Varda%3BRon%2C+Elaine&rft.aulast=Chodick&rft.aufirst=Gabriel&rft.date=2007-08-01&rft.volume=9&rft.issue=8&rft.spage=584&rft.isbn=&rft.btitle=&rft.title=The+Israel+Medical+Association+journal+%3A+IMAJ&rft.issn=15651088&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-02 N1 - Date created - 2007-09-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Isr Med Assoc J. 2007 Aug;9(8):607-9 [17877069] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sun exposure measurements in populations. AN - 68266756; 17867377 JF - Nutrition reviews AU - Tucker, Margaret A AD - Human Genetics Program, Chief, Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., Room 7122, Bethesda, MD 20892-7236, USA. tuckerp@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - S84 EP - S86 VL - 65 IS - 8 Pt 2 SN - 0029-6643, 0029-6643 KW - Vitamin D KW - 1406-16-2 KW - Index Medicus KW - Epidemiologic Methods KW - Humans KW - Sunlight -- adverse effects KW - Skin Neoplasms -- etiology KW - Environmental Exposure -- analysis KW - Ultraviolet Rays -- adverse effects KW - Skin Neoplasms -- epidemiology KW - Vitamin D -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68266756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nutrition+reviews&rft.atitle=Sun+exposure+measurements+in+populations.&rft.au=Tucker%2C+Margaret+A&rft.aulast=Tucker&rft.aufirst=Margaret&rft.date=2007-08-01&rft.volume=65&rft.issue=8+Pt+2&rft.spage=S84&rft.isbn=&rft.btitle=&rft.title=Nutrition+reviews&rft.issn=00296643&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-12 N1 - Date created - 2007-09-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The biology behind mTOR inhibition in sarcoma. AN - 68230176; 17766661 AB - Dysregulation of the mammalian target of rapamycin (mTOR) pathway has been found in many human tumors and implicated in the promotion of cancer cell growth and survival. Hence, the mTOR pathway is considered an important target for anticancer drug development. Currently, the mTOR inhibitor rapamycin and its derivatives CCI-779, RAD001, and AP23573 are being evaluated in cancer clinical trials. To date, clinical results have shown good tolerability of treatment with mTOR inhibitors in most reports and varying effectiveness of mTOR inhibitors in a variety of tumors in a subset of patients. For the targeted treatment of sarcomas, AP23573 has shown promising clinical efficacy and low toxicity profiles in patients. Further studies should define the optimal dose/schedule, patient selection, and combination strategies with other biological agents, especially those targeting signaling pathways crucial for cell survival. Disclosure of potential conflicts of interest is found at the end of this article. JF - The oncologist AU - Wan, Xiaolin AU - Helman, Lee J AD - Molecular Oncology Section, Pediatric Oncology Branch, Building 10, Room CRC-1W-3816, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1928, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1007 EP - 1018 VL - 12 IS - 8 SN - 1083-7159, 1083-7159 KW - Protein Kinase Inhibitors KW - 0 KW - ridaforolimus KW - 48Z35KB15K KW - temsirolimus KW - 624KN6GM2T KW - Everolimus KW - 9HW64Q8G6G KW - Protein Kinases KW - EC 2.7.- KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - MTOR protein, human KW - EC 2.7.1.1 KW - TOR Serine-Threonine Kinases KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Sirolimus KW - W36ZG6FT64 KW - Index Medicus KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Humans KW - Clinical Trials as Topic KW - Protein Kinase Inhibitors -- therapeutic use KW - Protein Kinase Inhibitors -- pharmacology KW - Protein Kinases -- drug effects KW - Sirolimus -- pharmacology KW - Protein Kinase Inhibitors -- chemistry KW - Sirolimus -- therapeutic use KW - Sarcoma -- drug therapy KW - Sarcoma -- enzymology KW - Sirolimus -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68230176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=The+biology+behind+mTOR+inhibition+in+sarcoma.&rft.au=Wan%2C+Xiaolin%3BHelman%2C+Lee+J&rft.aulast=Wan&rft.aufirst=Xiaolin&rft.date=2007-08-01&rft.volume=12&rft.issue=8&rft.spage=1007&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=10837159&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-31 N1 - Date created - 2007-09-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Seasonal birth patterns in myositis subgroups suggest an etiologic role of early environmental exposures. AN - 68207181; 17665425 AB - To evaluate whether seasonal early environmental exposures might influence later development of autoimmune disease, by assessing distributions of birth dates in groups of patients with idiopathic inflammatory myopathies (IIMs). We assessed birth patterns in groups of patients with juvenile-onset IIM (n = 307) and controls (n = 3,942) who were born between 1970 and 1999, and in groups of patients with adult-onset IIM (n = 668) and controls (n = 6,991) who were born between 1903 and 1982. Birth dates were analyzed as circular data. Seasonal clustering was assessed by the Rayleigh test, and differences between groups by a rank-based uniform scores test. The overall birth distributions among patients with juvenile IIM and among patients with adult IIM did not differ significantly from those among juvenile and adult controls, respectively. Some subgroups of patients with juvenile IIM had seasonal birth distributions. Hispanic patients with juvenile-onset IIM had a seasonal birth pattern (mean birth date October 16) significantly different from that of Hispanic controls (P = 0.002), who had a uniform birth distribution, and from that of non-Hispanic patients with juvenile-onset IIM (P < 0.001), who had a mean birth date of May 2. Juvenile dermatomyositis patients with p155 autoantibody had a birth distribution that differed significantly from that of p155 antibody-negative juvenile dermatomyositis patients (P = 0.003). Juvenile IIM patients with the HLA risk factor allele DRB1*0301 had a birth distribution significantly different from those without the allele (P = 0.021). Similar results were observed for juvenile and adult IIM patients with the linked allele DQA1*0501, versus juvenile and adult IIM patients without DQA1*0501, respectively. No significant patterns in birth season were found in other subgroups. Birth distributions appear to have stronger seasonality in juvenile than in adult IIM subgroups, suggesting greater influence of perinatal exposures on childhood-onset illness. Seasonal early-life exposures may influence the onset of some autoimmune diseases later in life. JF - Arthritis and rheumatism AU - Vegosen, Leora J AU - Weinberg, Clarice R AU - O'Hanlon, Terrance P AU - Targoff, Ira N AU - Miller, Frederick W AU - Rider, Lisa G AD - Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, NIH/DHHS, 10 Center Drive, Bethesda, MD 20892, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 2719 EP - 2728 VL - 56 IS - 8 SN - 0004-3591, 0004-3591 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Parturition KW - United States -- epidemiology KW - Time Factors KW - Cluster Analysis KW - Seasons KW - Myositis -- epidemiology KW - Environmental Exposure -- adverse effects KW - Myositis -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68207181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+and+rheumatism&rft.atitle=Seasonal+birth+patterns+in+myositis+subgroups+suggest+an+etiologic+role+of+early+environmental+exposures.&rft.au=Vegosen%2C+Leora+J%3BWeinberg%2C+Clarice+R%3BO%27Hanlon%2C+Terrance+P%3BTargoff%2C+Ira+N%3BMiller%2C+Frederick+W%3BRider%2C+Lisa+G&rft.aulast=Vegosen&rft.aufirst=Leora&rft.date=2007-08-01&rft.volume=56&rft.issue=8&rft.spage=2719&rft.isbn=&rft.btitle=&rft.title=Arthritis+and+rheumatism&rft.issn=00043591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-18 N1 - Date created - 2007-08-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hum Reprod. 1992 Jul;7(6):735-45 [1323571] BMJ. 1999 Oct 2;319(7214):887-8 [10506043] J Rheumatol. 1999 Feb;26(2):352-60 [9972969] J Immunol. 1997 Dec 15;159(12):6260-5 [9550430] Demography. 1996 Aug;33(3):291-305 [8875063] Arthritis Rheum. 1998 Mar;41(3):392-9 [9506565] Chronobiol Int. 1999 Sep;16(5):581-622 [10513884] J Am Coll Nutr. 2004 Dec;23(6 Suppl):588S-595S [15640511] BMJ. 2005 Jan 15;330(7483):120 [15585537] Immunol Cell Biol. 2005 Feb;83(1):9-17 [15661036] Isr Med Assoc J. 2005 Jun;7(6):381-4 [15984382] Arthritis Rheum. 2005 Aug;52(8):2433-8 [16052581] BMC Public Health. 2005;5:102 [16207379] N Engl J Med. 2005 Oct 27;353(17):1848-50 [16251542] Medicine (Baltimore). 2005 Nov;84(6):338-49 [16267409] Environ Health Perspect. 2005 Dec;113(12):1787-90 [16330365] Environ Health Perspect. 2005 Dec;113(12):1802-7 [16330368] Pediatr Pulmonol. 2006 Dec;41(12):1125-8 [17034060] Arthritis Rheum. 2006 Nov;54(11):3682-9 [17075819] Lupus. 2006;15(11):794-800 [17153853] Environ Health Perspect. 2006 Dec;114(12):1916-22 [17185285] Am J Psychiatry. 2000 Jul;157(7):1173-5 [10873932] Environ Health Perspect. 1999 Oct;107 Suppl 5:793-802 [10970168] J Pediatr Endocrinol Metab. 2001 Jan;14(1):47-52 [11220705] Emerg Infect Dis. 2001 May-Jun;7(3):369-74 [11384511] Hum Reprod. 2001 Jul;16(7):1512-7 [11425840] Environ Health Perspect. 2002 Jun;110 Suppl 3:441-9 [12060842] Arthritis Rheum. 2002 Jul;46(7):1885-93 [12124873] Gut. 2002 Dec;51(6):814-5 [12427782] Best Pract Res Clin Rheumatol. 2002 Dec;16(5):817-32 [12473276] Stat Med. 2003 Jul 15;22(13):2127-35 [12820278] Arthritis Rheum. 2003 Aug;48(8):2285-93 [12905483] Sleep. 2003 Sep15;26(6):663-5 [14572117] Diabetologia. 2004 Apr;47(4):614-21 [15298337] Am J Gastroenterol. 2004 Oct;99(10):1974-6 [15447759] N Engl J Med. 1975 Feb 13;292(7):344-7 [1090839] N Engl J Med. 1992 May 21;326(21):1380-4 [1472183] J Immunol. 1990 Mar 1;144(5):1737-43 [2307838] Diabetologia. 1984 Mar;26(3):199-202 [6609096] Lancet. 1988 Jun 25;1(8600):1461 [2898612] J Rheumatol. 1989 Sep;16(9):1225-8 [2681763] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Herbal hepatotoxicity. AN - 68205721; 17723921 AB - There is appropriate concern about the potential risk for hepatotoxicity from herbal products because they are unregulated and therefore not standardized with regard to their contents. This is particularly the case for the crude herbals that are commonly formulated as a mixture, so that their ingredients may be ambiguous and even contain harmful contaminants. Presented here is an overview of the more commonly recognized herbal products that have been reported to be associated with liver injury. Although many of them are clearly implicated, there are some, particularly those identified solely through an occasional case report, for which the relationship is uncertain. JF - Clinics in liver disease AU - Seeff, Leonard B AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 31 Center Drive, Room 9A27, Bethesda, MD 20892, USA. seeffl@extra.niddk.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 577 EP - 96, vii VL - 11 IS - 3 SN - 1089-3261, 1089-3261 KW - Drugs, Chinese Herbal KW - 0 KW - Plant Preparations KW - Index Medicus KW - Humans KW - Herb-Drug Interactions KW - Drugs, Chinese Herbal -- adverse effects KW - Plant Preparations -- adverse effects KW - Chemical and Drug Induced Liver Injury KW - Plants, Medicinal -- adverse effects KW - Phytotherapy -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68205721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinics+in+liver+disease&rft.atitle=Herbal+hepatotoxicity.&rft.au=Seeff%2C+Leonard+B&rft.aulast=Seeff&rft.aufirst=Leonard&rft.date=2007-08-01&rft.volume=11&rft.issue=3&rft.spage=577&rft.isbn=&rft.btitle=&rft.title=Clinics+in+liver+disease&rft.issn=10893261&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-08 N1 - Date created - 2007-08-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Analysis of toxicity in patients with high risk prostate cancer treated with intensity-modulated pelvic radiation therapy and simultaneous integrated dose escalation to prostate area. AN - 68201025; 17692416 AB - To report the treatment-related morbidity in patients with prostate cancer treated with an optimized pelvic intensity-modulated radiation therapy (IMRT) and simultaneous integrated dose escalation to prostate/prostate bed. Between November 2003 and May 2006, 55 patients with localized prostate cancer and >15% risk of lymph node involvement were treated with pelvic IMRT and simultaneous dose escalation to prostate area. Twenty-four patients received a radical radiation therapy program, and the remaining thirty-one patients received a postoperative irradiation as adjuvant treatment or after biochemical or macroscopic local/regional relapse. After a customized immobilization all patients underwent contrast-enhanced CT. On the CT slices CTV1 and CTV2 were delineated. CTV(1) included the prostate and seminal vesicles or prostate bed. CTV(2) consisted of CTV(1) plus pelvic nodes. CTV(1) and CTV(2) were then expanded by 0.5 and 1cm, respectively, to generate the planning target volumes. IMRT treatment plans were generated using commercial inverse planning software. Total doses of 66-80 Gy and 50-59 Gy in 33-40 fractions were prescribed to the prostate area and pelvis, respectively. The worst acute and late rectal, intestinal and GU toxicities during and after treatment were scored according to the EORTC/RTOG scales. The IMRT dose distribution provided excellent PTV coverage and satisfying sparing of all the organs at risk, with no patient experiencing >grade 2 acute or late toxicities. Patients without acute grade 2 intestinal, rectal, and GU toxicity were 91%, 71%, and 63%, respectively. After a median follow-up of 19 months (interquartile range of 9 to 28 months), late grade 2 toxicity was detected only for rectum, with an actuarial 2-year rate of freedom from G2 rectal bleeding of 92%. (CI 95% 0.83-0.99.) Pelvic IMRT and simultaneous dose escalation to prostate area is a well-tolerated technique in patients with prostate cancer requiring treatment of pelvic lymph nodes, and seems to be associated with a lower frequency and severity of side effects when compared with conventional techniques reported in other series. JF - Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology AU - Arcangeli, Stefano AU - Saracino, Biancamaria AU - Petrongari, Maria Grazia AU - Gomellini, Sara AU - Marzi, Simona AU - Landoni, Valeria AU - Gallucci, Michele AU - Sperduti, Isabella AU - Arcangeli, Giorgio AD - Department of Radiation Oncology, Regina Elena National Cancer Institute, Rome, Italy. arcangeli@ifo.it Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 148 EP - 155 VL - 84 IS - 2 SN - 0167-8140, 0167-8140 KW - Index Medicus KW - Radiotherapy Planning, Computer-Assisted KW - Radiation Dosage KW - Radiotherapy, Adjuvant KW - Aged, 80 and over KW - Humans KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Prostate -- radiation effects KW - Pelvis -- radiation effects KW - Radiotherapy, Intensity-Modulated -- adverse effects KW - Prostatic Neoplasms -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68201025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiotherapy+and+oncology+%3A+journal+of+the+European+Society+for+Therapeutic+Radiology+and+Oncology&rft.atitle=Analysis+of+toxicity+in+patients+with+high+risk+prostate+cancer+treated+with+intensity-modulated+pelvic+radiation+therapy+and+simultaneous+integrated+dose+escalation+to+prostate+area.&rft.au=Arcangeli%2C+Stefano%3BSaracino%2C+Biancamaria%3BPetrongari%2C+Maria+Grazia%3BGomellini%2C+Sara%3BMarzi%2C+Simona%3BLandoni%2C+Valeria%3BGallucci%2C+Michele%3BSperduti%2C+Isabella%3BArcangeli%2C+Giorgio&rft.aulast=Arcangeli&rft.aufirst=Stefano&rft.date=2007-08-01&rft.volume=84&rft.issue=2&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Radiotherapy+and+oncology+%3A+journal+of+the+European+Society+for+Therapeutic+Radiology+and+Oncology&rft.issn=01678140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-23 N1 - Date created - 2007-08-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hair dye use, genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma. AN - 68180117; 17522066 AB - Several previous studies have found non-Hodgkin lymphoma (NHL) risk to be associated with hair dye use, particularly use of permanent, dark colors and use before 1980, when hair dye formulations changed. We examined NHL risk in relation to reported hair dye use among 1,321 cases and 1,057 controls from a US population-based multi-center study. DNA was extracted from blood or buccal cells to identify genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), which encode enzymes that metabolize aromatic amine compounds found in hair dyes. Among women, 509 cases and 413 controls reported hair dye use [odds ratio (OR) = 1.2; 95% confidence interval (95% CI) = 0.9, 1.6]. Risk estimates were higher for use before 1980 than for use in 1980 or later, particularly for use of permanent, intense tone (black, dark brown, dark blonde) products (or=1980-OR = 0.6; 95% CI 0.4, 1.1). Risk estimates were increased for women who used permanent, intense tone products before 1980 if they had the rapid/intermediate NAT2 phenotype (OR = 3.3; 95% CI 1.3, 8.6) or the NAT1 10 allele (OR = 2.5; 95% CI 0.9, 7.6), but not if they were slow NAT2 acetylators (OR = 1.5; 95% CI 0.6, 3.6) or had no copies of the NAT1 10 allele (OR = 1.5; 95% CI 0.7, 3.3). NHL risk was not increased among women who began hair dye use after 1980 or among men. Our results support previous research demonstrating elevated NHL risk among women who used dark color or intense tone permanent hair dyes before 1980. We present the first evidence suggesting that this risk may differ by genetic variation in NAT1 and NAT2. JF - Carcinogenesis AU - Morton, Lindsay M AU - Bernstein, Leslie AU - Wang, Sophia S AU - Hein, David W AU - Rothman, Nathaniel AU - Colt, Joanne S AU - Davis, Scott AU - Cerhan, James R AU - Severson, Richard K AU - Welch, Robert AU - Hartge, Patricia AU - Zahm, Shelia Hoar AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA. mortonli@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1759 EP - 1764 VL - 28 IS - 8 SN - 0143-3334, 0143-3334 KW - Hair Dyes KW - 0 KW - Isoenzymes KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - N-acetyltransferase 1 KW - NAT2 protein, human KW - Index Medicus KW - Risk Factors KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Male KW - Female KW - Lymphoma, Non-Hodgkin -- genetics KW - Genetic Variation KW - Lymphoma, Non-Hodgkin -- etiology KW - Lymphoma, Non-Hodgkin -- enzymology KW - Hair Dyes -- adverse effects KW - Genetic Predisposition to Disease KW - Isoenzymes -- genetics KW - Arylamine N-Acetyltransferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68180117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Hair+dye+use%2C+genetic+variation+in+N-acetyltransferase+1+%28NAT1%29+and+2+%28NAT2%29%2C+and+risk+of+non-Hodgkin+lymphoma.&rft.au=Morton%2C+Lindsay+M%3BBernstein%2C+Leslie%3BWang%2C+Sophia+S%3BHein%2C+David+W%3BRothman%2C+Nathaniel%3BColt%2C+Joanne+S%3BDavis%2C+Scott%3BCerhan%2C+James+R%3BSeverson%2C+Richard+K%3BWelch%2C+Robert%3BHartge%2C+Patricia%3BZahm%2C+Shelia+Hoar&rft.aulast=Morton&rft.aufirst=Lindsay&rft.date=2007-08-01&rft.volume=28&rft.issue=8&rft.spage=1759&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-19 N1 - Date created - 2007-08-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 1994 Jun 15;86(12):941-4 [8196085] Carcinogenesis. 2006 Aug;27(8):1600-6 [16497705] Cancer Causes Control. 1999 Dec;10(6):617-25 [10616830] Cancer Epidemiol Biomarkers Prev. 2000 Jan;9(1):29-42 [10667461] Pharmacogenetics. 2000 Jun;10(4):291-2 [10862519] Drug Metab Dispos. 2000 Dec;28(12):1425-32 [11095579] Int J Cancer. 2001 Feb 15;91(4):575-9 [11251984] Cancer Epidemiol Biomarkers Prev. 2001 Jun;10(6):687-96 [11401920] Pharmacogenomics. 2002 Jan;3(1):19-30 [11966400] Br J Haematol. 2002 Aug;118(2):477-81 [12139735] Mutat Res. 2002 Sep 30;506-507:65-77 [12351146] Carcinogenesis. 2003 Mar;24(3):483-9 [12663508] Chem Res Toxicol. 2003 Sep;16(9):1162-73 [12971805] Am J Epidemiol. 2004 Jan 15;159(2):148-54 [14718216] Curr Pharm Des. 2004;10(20):2519-24 [15320760] Proc Natl Acad Sci U S A. 1975 Jun;72(6):2423-7 [1094469] J Environ Pathol Toxicol. 1980 Mar;3(4 Spec No):237-51 [6993608] J Natl Cancer Inst. 1981 Mar;66(3):591-602 [6937712] Cancer Chemother Pharmacol. 1987;20(3):235-8 [3677298] Am J Public Health. 1988 May;78(5):570-1 [3354743] Zhonghua Yu Fang Yi Xue Za Zhi. 1990 Nov;24(6):328-31 [2099267] Am J Public Health. 1992 Jul;82(7):990-7 [1609918] J Natl Cancer Inst. 1994 Feb 2;86(3):210-5 [8283493] J Toxicol Environ Health B Crit Rev. 2006 Sep-Oct;9(5):413-39 [17492526] IARC Monogr Eval Carcinog Risks Hum. 1993;57:7-398 [7911535] J Natl Cancer Inst. 1994 Oct 5;86(19):1466-70 [8089866] Am J Public Health. 1998 Dec;88(12):1767-73 [9842372] Am J Ind Med. 1999 Jul;36(1):60-9 [10361588] Carcinogenesis. 1999 Jul;20(7):1225-9 [10383893] Pol J Pharmacol. 2004 Jul-Aug;56(4):445-9 [15520499] Int J Cancer. 2005 Feb 10;113(4):629-31 [15389468] Br J Haematol. 2005 Mar;128(5):610-5 [15725081] JAMA. 2005 May 25;293(20):2516-25 [15914752] JAMA. 2005 Sep 14;294(10):1205; author reply 1205 [16160127] Cancer Causes Control. 2005 Dec;16(10):1203-14 [16215871] Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2449-53 [16214931] Int J Epidemiol. 2005 Oct;34(5):1118-22 [15914502] Int J Cancer. 2006 Jan 1;118(1):161-8 [16003747] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D617-21 [16381944] Am J Epidemiol. 2006 Feb 1;163(3):197-203 [16339049] Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):251-7 [16492912] Oncogene. 2006 Mar 13;25(11):1649-58 [16550165] Eur J Cancer. 2006 Jul;42(10):1448-54 [16740387] Am J Epidemiol. 2006 Jul 1;164(1):47-55 [16731576] Pharmacogenet Genomics. 2006 Aug;16(8):537-45 [16847422] Comment In: Carcinogenesis. 2008 May;29(5):1084-5 [18212328] Carcinogenesis. 2008 Sep;29(9):1851 [18218828] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer risk. AN - 68179865; 17557904 AB - The double-strand break DNA repair (DSBR) pathway is implicated in maintaining genomic stability and therefore could affect bladder cancer risk. Here we present data evaluating 39 single-nucleotide polymorphisms (SNPs) in seven candidate genes whose products are involved in DNA break sensing (NBS1, BRCA1 interacting genes BRIP1 and ZNF350), non-homologous end-joining (NHEJ) DNA repair (XRCC4) and homologous recombination (HR) repair (RAD51, XRCC2 and XRCC3). SNPs for RAD51 and XRCC2 covered most of the common variation. Associations with bladder cancer risk were evaluated in 1,150 newly diagnosed cases of urinary bladder transitional cell carcinomas and 1,149 controls conducted in Spain during 1997-2001. We found that the genetic variants evaluated significantly contributed to bladder cancer risk (global likelihood ratio test P = 0.01). Subjects with the ZNF350 R501S (rs2,278,415) variant allele showed significantly reduced risk compared with common homozygote variants, odds ratio (OR) [95% confidence interval (95% CI)]: 0.76 (0.62-0.93) per variant allele. Carriers of a putative functional SNP in intron 7 of XRCC4 (rs1,805,377) had significantly increased bladder cancer risk compared with common homozygotes: 1.33 (1.08-1.64) per variant allele. Lastly, XRCC2 homozygote variants for three promoter SNPs (rs10,234,749, rs6,464,268, rs3,218,373) and one non-synonymous SNP (rs3,218,536, R188H) were associated with reduced bladder cancer risk (ORs ranging from 0.36 to 0.50 compared with common homozygotes). Meta-analysis for XRCC3 T241M (rs861,539) had a significant small increase in risk among homozygote variants: OR (95% CI) = 1.17 (1.00-1.36). Results from this study provide evidence for associations between variants in genes in the DSBR pathway and bladder cancers risk that warrant replication in other study populations. JF - Carcinogenesis AU - Figueroa, Jonine D AU - Malats, Núria AU - Rothman, Nathaniel AU - Real, Francisco X AU - Silverman, Debra AU - Kogevinas, Manolis AU - Chanock, Stephen AU - Yeager, Meredith AU - Welch, Robert AU - Dosemeci, Mustafa AU - Tardón, Adonina AU - Serra, Consol AU - Carrato, Alfredo AU - García-Closas, Reina AU - Castaño-Vinyals, Gemma AU - García-Closas, Montserrat AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA. figueroaj@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1788 EP - 1793 VL - 28 IS - 8 SN - 0143-3334, 0143-3334 KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Aged, 80 and over KW - Risk Factors KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - DNA Repair -- genetics KW - Genetic Variation KW - Urinary Bladder Neoplasms -- genetics KW - Genetic Predisposition to Disease KW - DNA Breaks, Double-Stranded KW - Carcinoma, Transitional Cell -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68179865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Evaluation+of+genetic+variation+in+the+double-strand+break+repair+pathway+and+bladder+cancer+risk.&rft.au=Figueroa%2C+Jonine+D%3BMalats%2C+N%C3%BAria%3BRothman%2C+Nathaniel%3BReal%2C+Francisco+X%3BSilverman%2C+Debra%3BKogevinas%2C+Manolis%3BChanock%2C+Stephen%3BYeager%2C+Meredith%3BWelch%2C+Robert%3BDosemeci%2C+Mustafa%3BTard%C3%B3n%2C+Adonina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BGarc%C3%ADa-Closas%2C+Reina%3BCasta%C3%B1o-Vinyals%2C+Gemma%3BGarc%C3%ADa-Closas%2C+Montserrat&rft.aulast=Figueroa&rft.aufirst=Jonine&rft.date=2007-08-01&rft.volume=28&rft.issue=8&rft.spage=1788&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-19 N1 - Date created - 2007-08-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hypoxic suppression of the cell cycle gene CDC25A in tumor cells. AN - 68173789; 17671423 AB - Hypoxia, a key microenvironmental factor for tumor development, not only stimulates angiogenesis and glycolysis for tumor expansion, but also induces cell cycle arrest and genetic instability for tumor progression. Several independent studies have shown hypoxic blockade of cell cycle progression at the G1/S transition, arising from the inactivation of S-phase-promoting cyclin E-CDK2 kinase complex. Despite these findings, the biochemical pathways leading to the cell cycle arrest remain poorly defined. We recently showed that hypoxic activates the expression of CDNK1A encoding the CDK2 inhibitor p21Cip1, through a novel HIF-1alpha-Myc pathway that involves Myc displacement from the CDNK1A promoter by the hypoxia-inducible transcription factor HIF-1alpha. In pursuit of further understanding of the hypoxic effects on cell cycle in tumor cells, here we report that hypoxia inhibits the expression of CDC25A, another cell cycle gene encoding a tyrosine phosphatase that maintains CDK2 activity. In accordance with the HIF-1alpha-Myc pathway, hypoxia requires HIF-1alpha for CDC25A repression, resulting in a selective displacement of an activating Myc from the CDC25A promoter without affecting a canonical Myc binding in the intron. Intriguingly, HIF-1alpha alone fails to recapitulate the hypoxic effect, indicating that HIF-1alpha is necessary but insufficient for the hypoxic repression. Taken together, our studies indicate that hypoxia inhibits cell cycle progression by controlling the expression of various cell cycle genes. JF - Cell cycle (Georgetown, Tex.) AU - Hammer, Stefanie AU - To, Kenneth K-W AU - Yoo, Young-Gun AU - Koshiji, Minori AU - Huang, L Eric AD - Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland, USA. Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 1919 EP - 1926 VL - 6 IS - 15 KW - Cell Cycle Proteins KW - 0 KW - HIF1A protein, human KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - Proto-Oncogene Proteins c-myc KW - Tumor Suppressor Protein p53 KW - Protein Kinases KW - EC 2.7.- KW - ATR protein, human KW - EC 2.7.11.1 KW - Ataxia Telangiectasia Mutated Proteins KW - Checkpoint Kinase 1 KW - Protein-Serine-Threonine Kinases KW - CDC25A protein, human KW - EC 3.1.3.48 KW - cdc25 Phosphatases KW - Index Medicus KW - Protein-Serine-Threonine Kinases -- metabolism KW - Humans KW - Transcription, Genetic -- genetics KW - Proto-Oncogene Proteins c-myc -- genetics KW - Cell Differentiation KW - Cell Line, Tumor KW - Proto-Oncogene Proteins c-myc -- metabolism KW - Cell Proliferation KW - Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism KW - Tumor Suppressor Protein p53 -- metabolism KW - Cell Cycle Proteins -- metabolism KW - Protein Kinases -- metabolism KW - Gene Expression Profiling KW - Cell Hypoxia -- genetics KW - Hypoxia-Inducible Factor 1, alpha Subunit -- genetics KW - Promoter Regions, Genetic -- genetics KW - Signal Transduction KW - Neoplasms -- pathology KW - Neoplasms -- enzymology KW - Down-Regulation -- genetics KW - cdc25 Phosphatases -- genetics KW - cdc25 Phosphatases -- metabolism KW - Neoplasms -- genetics KW - Gene Expression Regulation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68173789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+cycle+%28Georgetown%2C+Tex.%29&rft.atitle=Hypoxic+suppression+of+the+cell+cycle+gene+CDC25A+in+tumor+cells.&rft.au=Hammer%2C+Stefanie%3BTo%2C+Kenneth+K-W%3BYoo%2C+Young-Gun%3BKoshiji%2C+Minori%3BHuang%2C+L+Eric&rft.aulast=Hammer&rft.aufirst=Stefanie&rft.date=2007-08-01&rft.volume=6&rft.issue=15&rft.spage=1919&rft.isbn=&rft.btitle=&rft.title=Cell+cycle+%28Georgetown%2C+Tex.%29&rft.issn=1551-4005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-26 N1 - Date created - 2007-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Medication-related impulse control and repetitive behaviors in Parkinson disease. AN - 68161388; 17698698 AB - A range of behaviors presumed to be related to aberrant or excessive dopaminergic medications are being increasingly recognized in Parkinson disease. These behaviors are linked by their incentive- or reward-based and repetitive natures and include pathological gambling, hypersexuality, compulsive shopping, compulsive eating, hobbyism, and compulsive medication use. Such behaviors can have potentially devastating psychosocial consequences and are often hidden. Whether these behaviors are simply related to dopaminergic medications interacting with an underlying individual vulnerability or whether the primary pathological features of Parkinson disease play a role is not known. We reviewed the literature on these behaviors in Parkinson disease, including definitions, epidemiological and potential pathophysiological features, and management. The study of these behaviors allows not only improved clinical management but also greater insight into a biologically mediated complex behavioral model. JF - Archives of neurology AU - Voon, Valerie AU - Fox, Susan H AD - National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Dr, Bldg 10, Room 5S213, Bethesda, MD 20892-1428, USA. voonv@ninds.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1089 EP - 1096 VL - 64 IS - 8 SN - 0003-9942, 0003-9942 KW - Antiparkinson Agents KW - 0 KW - Dopamine Agents KW - Abridged Index Medicus KW - Index Medicus KW - Disease Susceptibility KW - Humans KW - Dopamine Agents -- adverse effects KW - Terminology as Topic KW - Prevalence KW - Disruptive, Impulse Control, and Conduct Disorders -- epidemiology KW - Disruptive, Impulse Control, and Conduct Disorders -- chemically induced KW - Antiparkinson Agents -- adverse effects KW - Disruptive, Impulse Control, and Conduct Disorders -- therapy KW - Mental Disorders -- therapy KW - Disruptive, Impulse Control, and Conduct Disorders -- physiopathology KW - Mental Disorders -- epidemiology KW - Mental Disorders -- chemically induced KW - Antiparkinson Agents -- therapeutic use KW - Parkinson Disease -- drug therapy KW - Mental Disorders -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68161388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+neurology&rft.atitle=Medication-related+impulse+control+and+repetitive+behaviors+in+Parkinson+disease.&rft.au=Voon%2C+Valerie%3BFox%2C+Susan+H&rft.aulast=Voon&rft.aufirst=Valerie&rft.date=2007-08-01&rft.volume=64&rft.issue=8&rft.spage=1089&rft.isbn=&rft.btitle=&rft.title=Archives+of+neurology&rft.issn=00039942&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-18 N1 - Date created - 2007-08-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Arsenic, internal cancers, and issues in inference from studies of low-level exposures in human populations. AN - 68157211; 17382983 AB - Epidemiologic data from regions of the world with very high levels of arsenic in drinking water (>150 microg/L) show a strong association between arsenic exposure and risk of several internal cancers. A causal interpretation of the data is warranted based on the strength and consistency of study findings. At lower levels of exposure (<100 microg/L), in the absence of unambiguous human data, extrapolation from the high-exposure studies has been used to estimate risk. Misclassification of exposure usually results in depressing observed levels of risk, and studies conducted in populations with exposures below 100 microg/L have been limited by the challenge of estimating past exposures, a critically important aspect of studying relative small increases in risk. Relatively small study size contributes to the variability of findings in most studies and makes interpretation of results all the more challenging. The effects on risk estimates of exposure misclassification and small study size under various scenarios are graphically illustrated. Efforts are underway to improve exposure assessment in a large case-control study of bladder cancer in a region of the United States with moderately elevated levels of arsenic in drinking water. JF - Toxicology and applied pharmacology AU - Cantor, Kenneth P AU - Lubin, Jay H AD - Division of Cancer Epidemiology and Genetics, 8106 EPS, National Cancer Institute, Bethesda, MD 20892-7240, USA. cantork@nih.gov Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 252 EP - 257 VL - 222 IS - 3 SN - 0041-008X, 0041-008X KW - Carcinogens KW - 0 KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Animals KW - Water Supply -- analysis KW - Urinary Bladder Neoplasms -- epidemiology KW - Humans KW - Environmental Exposure KW - Urinary Bladder Neoplasms -- chemically induced KW - Risk Assessment KW - Arsenic -- toxicity KW - Neoplasms -- chemically induced KW - Neoplasms -- epidemiology KW - Carcinogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68157211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Arsenic%2C+internal+cancers%2C+and+issues+in+inference+from+studies+of+low-level+exposures+in+human+populations.&rft.au=Cantor%2C+Kenneth+P%3BLubin%2C+Jay+H&rft.aulast=Cantor&rft.aufirst=Kenneth&rft.date=2007-08-01&rft.volume=222&rft.issue=3&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-28 N1 - Date created - 2007-08-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Epidemiol. 2000 Mar 15;151(6):554-65 [10733037] Environ Sci Technol. 2006 Jun 1;40(11):3578-85 [16786697] Epidemiology. 2000 Nov;11(6):673-9 [11055628] Am J Epidemiol. 2001 Mar 1;153(5):411-8 [11226969] J Expo Anal Environ Epidemiol. 2002 Sep;12(5):329-34 [12198581] Environ Sci Technol. 2003 May 15;37(10):2075-83 [12785510] Am J Epidemiol. 2003 Dec 15;158(12):1193-201 [14652304] Am J Epidemiol. 2004 Feb 15;159(4):381-9 [14769642] Cancer Causes Control. 2004 Jun;15(5):465-72 [15286466] Int J Epidemiol. 2004 Oct;33(5):945-6 [15319401] Am J Epidemiol. 2004 Nov 1;160(9):853-9 [15496537] Ann Intern Med. 1972 Dec;77(6):935-7 [4509227] Can Med Assoc J. 1975 Sep 6;113(5):396-401 [125622] Arch Dermatol. 1978 Mar;114(3):378-81 [629571] Arch Dermatol. 1978 Apr;114(4):602-3 [646380] Am J Pathol. 1978 Aug;92(2):349-76 [567014] Orv Hetil. 1980 Apr 27;121(17):1009-11 [7383675] Am J Epidemiol. 1982 Dec;116(6):895-911 [7148816] Am J Epidemiol. 1989 Dec;130(6):1123-32 [2589305] Environ Health Perspect. 1992 Jul;97:259-67 [1396465] Am J Epidemiol. 1992 Aug 15;136(4):417-21 [1415161] Am J Epidemiol. 1995 Mar 15;141(6):523-30 [7900719] Epidemiology. 1996 Mar;7(2):117-24 [8834549] Am J Epidemiol. 1998 Apr 1;147(7):660-9 [9554605] Int J Epidemiol. 1998 Aug;27(4):561-9 [9758107] Environ Health Perspect. 1999 May;107(5):359-65 [10210691] Environ Health Perspect. 1999 Sep;107(9):705-10 [10464069] Cancer. 1953 Mar;6(2):347-59 [13032927] JAMA. 2004 Dec 22;292(24):2984-90 [15613666] J Occup Environ Med. 2006 Apr;48(4):376-80 [16607191] Environ Health Perspect. 2000 Jul;108(7):655-61 [10903620] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The interferon-alpha responsive gene TMEM7 suppresses cell proliferation and is downregulated in human hepatocellular carcinoma. AN - 68155448; 17693185 AB - Multiple regions on the chromosome arm 3p are frequently affected by loss of heterozygosity in human cancers. A candidate tumor suppressor gene is TMEM7, at 3p21.3, which encodes a transmembrane protein. TMEM7 is expressed specifically in the liver, and the encoded protein shares substantial sequence homology with human and mouse 28-kDa interferon-alpha (IFN-alpha) responsive protein. In investigation of the possible role of TMEM7 in development of hepatocellular carcinoma (HCC), we examined TMEM7 expression in 20 primary HCC and 18 HCC cell lines and found recurrent functional alterations. Although TMEM7 mRNA was expressed in normal hepatic cells, downregulation or inactivation of the gene was detected in 85% of primary HCC and 33% of HCC cell lines. To identify the mechanisms responsible, we examined genomic deletion and mutation, and also the effect of inhibitors of DNA methyltransferase and histone deacetylase on cells with low or no endogenous TMEM7 expression. Homozygous deletion of TMEM7 was not detected in 17 pairs of human HCC and corresponding noncancerous liver tissues, nor in any of the 18 HCC cell lines. TMEM7 mutation was not detected in the 18 HCC cell lines (low or normal TMEM7 expression). Treatment of two of six cell lines exhibiting downregulation or loss of TMEM7 with 5-aza-2'-deoxycytidine and trichostatin A yielded additive increase in TMEM7 expression, implicating aberrant DNA methylation and histone deacetylation in transcriptional silencing of this gene. Ectopic expression of TMEM7 in two TMEM7-deficient HCC lines suppressed cell proliferation, colony formation, and cell migration in vitro and reduced tumor formation in nude mice. Treatment of two highly invasive HCC cell lines with IFN-alpha for 7 days significantly increased TMEM7 expression and inhibited cell migration. These findings implicate loss of TMEM7 expression in hepatocarcinogenesis and suggest that modification of TMEM7 expression by IFN-alpha may have therapeutic relevance in a subset of HCC. JF - Cancer genetics and cytogenetics AU - Zhou, Xiaoling AU - Popescu, Nicholas C AU - Klein, George AU - Imreh, Stephan AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Building 37, Room 4128, 37 Convent Drive, MSC 4264, Bethesda, MD 20892-4255, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 6 EP - 15 VL - 177 IS - 1 SN - 0165-4608, 0165-4608 KW - Histone Deacetylase Inhibitors KW - 0 KW - Hydroxamic Acids KW - Interferon-alpha KW - trichostatin A KW - 3X2S926L3Z KW - decitabine KW - 776B62CQ27 KW - Azacitidine KW - M801H13NRU KW - Index Medicus KW - Animals KW - Azacitidine -- pharmacology KW - Azacitidine -- analogs & derivatives KW - Humans KW - Mice, Nude KW - Mice KW - Amino Acid Sequence KW - Cell Line, Tumor KW - Epigenesis, Genetic KW - Promoter Regions, Genetic KW - DNA Methylation KW - Molecular Sequence Data KW - Sequence Homology, Amino Acid KW - Hydroxamic Acids -- pharmacology KW - Immunohistochemistry KW - Male KW - Neoplasm Invasiveness -- prevention & control KW - Interferon-alpha -- pharmacology KW - Gene Silencing KW - Carcinoma, Hepatocellular -- genetics KW - Genes, Tumor Suppressor -- physiology KW - Cell Proliferation KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68155448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+genetics+and+cytogenetics&rft.atitle=The+interferon-alpha+responsive+gene+TMEM7+suppresses+cell+proliferation+and+is+downregulated+in+human+hepatocellular+carcinoma.&rft.au=Zhou%2C+Xiaoling%3BPopescu%2C+Nicholas+C%3BKlein%2C+George%3BImreh%2C+Stephan&rft.aulast=Zhou&rft.aufirst=Xiaoling&rft.date=2007-08-01&rft.volume=177&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Cancer+genetics+and+cytogenetics&rft.issn=01654608&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-04 N1 - Date created - 2007-08-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Lett. 2003 Mar 10;191(2):155-64 [12618328] BMC Cancer. 2002 Nov 15;2:29 [12433278] Hepatology. 2003 Apr;37(4):739-41 [12668963] Hepatology. 2003 Apr;37(4):852-61 [12668978] Am J Pathol. 2003 Sep;163(3):1101-7 [12937151] Genes Chromosomes Cancer. 2003 Dec;38(4):307-21 [14566849] N Engl J Med. 2003 Nov 20;349(21):2042-54 [14627790] J Interferon Cytokine Res. 2003 Dec;23(12):745-56 [14769151] Oncogene. 2004 Feb 12;23(6):1308-13 [14647417] Cancer Res. 2000 Feb 15;60(4):1049-53 [10706123] Curr Opin Immunol. 2000 Aug;12(4):419-24 [10899033] Lab Invest. 2001 Apr;81(4):613-27 [11304581] Cancer Res. 2001 Nov 15;61(22):8094-9 [11719434] Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14763-5 [11752421] Nat Rev Cancer. 2001 Dec;1(3):194-202 [11902574] Eur J Hum Genet. 2002 Jan;10(1):52-61 [11896456] Nat Rev Genet. 2002 Jun;3(6):415-28 [12042769] Nat Genet. 2002 Aug;31(4):339-46 [12149612] Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15584-9 [12438687] Nature. 2002 Dec 5;420(6915):563-73 [12466851] Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903 [12477932] Oncogene. 2003 Jan 23;22(3):445-50 [12545165] Oncogene. 2004 Feb 19;23(7):1405-11 [14661059] Int J Oncol. 2004 Apr;24(4):837-45 [15010820] N Engl J Med. 1999 Mar 11;340(10):745-50 [10072408] Hepatology. 1999 Apr;29(4):1208-14 [10094966] Biofactors. 2004;21(1-4):69-72 [15630172] Int J Cancer. 2005 Jul 10;115(5):684-9 [15704097] Clin Cancer Res. 2006 Mar 1;12(5):1412-9 [16533763] Am J Pathol. 2006 Apr;168(4):1375-84 [16565510] Cancer Res. 2006 Jun 15;66(12):6361-9 [16778214] Oncogene. 2003 Mar 27;22(12):1866-71 [12660822] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Molecular targets for nutritional preemption of cancer. AN - 68152974; 17691899 AB - Malignant cells are characterized by alterations in multiple signaling pathways that promote proliferation, inhibit apoptosis, promote angiogenesis in the case of solid tumors, and enable cancer cells to invade and migrate through tissues. A variety of foods and their bioactive dietary constituents appear to have merit in reducing cancer risk and modifying tumor behavior. All of the major signaling pathways, which are deregulated in cancer, and which serve as potential targets for cancer prevention, have been reported to respond to one or more dietary components. Herein, we provide a brief overview of the importance of diet as a modifier of carcinogen metabolism, DNA repair, cell proliferation, apoptosis, inflammation, immunity, differentiation, angiogenesis, hormonal regulation and cellular energetics. This special issue of Current Cancer Drug Targets provides a collection of articles from researchers who are actively involved in examining the role of dietary components in cancer prevention and therapy. The remaining articles in this series provide more details about the specifics about the importance of these processes during carcinogenesis and proof-of-principal about the modifying capabilities of food patterns, specific foods and individual bioactive food components. JF - Current cancer drug targets AU - Davis, Cindy D AU - Milner, John A AD - Nutritional Science Research Group, National Cancer Institute, Rockville, MD 20892, USA. davisci@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 410 EP - 415 VL - 7 IS - 5 KW - Index Medicus KW - Signal Transduction -- physiology KW - Animals KW - Humans KW - Signal Transduction -- genetics KW - Signal Transduction -- immunology KW - Diet -- methods KW - Neoplasms -- pathology KW - Neoplasms -- prevention & control KW - Neoplasms -- diet therapy KW - Neoplasms -- genetics KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68152974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+cancer+drug+targets&rft.atitle=Molecular+targets+for+nutritional+preemption+of+cancer.&rft.au=Davis%2C+Cindy+D%3BMilner%2C+John+A&rft.aulast=Davis&rft.aufirst=Cindy&rft.date=2007-08-01&rft.volume=7&rft.issue=5&rft.spage=410&rft.isbn=&rft.btitle=&rft.title=Current+cancer+drug+targets&rft.issn=1873-5576&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-10 N1 - Date created - 2007-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma. AN - 68147812; 17684125 AB - alpha-Methylacyl-CoA racemase (AMACR), an enzyme involved in oxidation of branched chain fatty acids and cholesterol metabolites, as well as ibuprofen metabolism, is overexpressed in colorectal adenomas and cancer. AMACR gene variants have been associated with hereditary prostate cancer, but no studies have evaluated their etiologic role in colorectal carcinogenesis. We conducted a case-control study of 725 advanced distal colorectal adenoma cases and 729 frequency-matched controls from the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Seven AMACR polymorphisms were genotyped. Unconditional logistic regression models were used to evaluate the associations adjusting for age at randomization and gender. The 201L allele of S201L [TT versus CC: odds ratio (OR), 1.74; 95% confidence interval (95% CI), 1.15-2.62; TC versus CC: OR, 1.17; 95% CI, 0.93-1.49] and the 277E allele of K277E (GG versus AA: OR, 1.66; 95% CI, 1.03-2.68; GA versus AA: OR, 1.21; 95% CI, 0.96-1.53) were associated with increased risk of advanced distal colorectal adenoma (both P(trend) or =110% of the prescribed dose and an 8% increase in the target volume receiving > or =95% of the prescribed dose. Although target homogeneity was improved, the maximum dose delivered in the paraspinal muscles was increased by approximately 8.5% with spinal IMRT compared to the PA technique. Follow-up evaluations revealed no unexpected toxicity associated with the IMRT technique. A new technique of spine IMRT is presented in combination with a quality assurance method. This method improves target dose uniformity compared to the conventional CSI technique. Longer follow-up will be required to determine any benefit with regard to toxicity and disease control. JF - International journal of radiation oncology, biology, physics AU - Pai Panandiker, Atmaram AU - Ning, Holly AU - Likhacheva, Anna AU - Ullman, Karen AU - Arora, Barbara AU - Ondos, John AU - Karimpour, Shervin AU - Packer, Roger AU - Miller, Robert AU - Citrin, Deborah AD - Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 1402 EP - 1409 VL - 68 IS - 5 SN - 0360-3016, 0360-3016 KW - Index Medicus KW - Spine -- radiation effects KW - Spinal Cord -- radiation effects KW - Radiotherapy Dosage KW - Humans KW - Adult KW - Child KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Radiotherapy, Intensity-Modulated -- standards KW - Supine Position KW - Radiotherapy, Intensity-Modulated -- methods KW - Brain Neoplasms -- radiotherapy KW - Spinal Neoplasms -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68127431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=Craniospinal+irradiation+with+spinal+IMRT+to+improve+target+homogeneity.&rft.au=Pai+Panandiker%2C+Atmaram%3BNing%2C+Holly%3BLikhacheva%2C+Anna%3BUllman%2C+Karen%3BArora%2C+Barbara%3BOndos%2C+John%3BKarimpour%2C+Shervin%3BPacker%2C+Roger%3BMiller%2C+Robert%3BCitrin%2C+Deborah&rft.aulast=Pai+Panandiker&rft.aufirst=Atmaram&rft.date=2007-08-01&rft.volume=68&rft.issue=5&rft.spage=1402&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-09 N1 - Date created - 2007-08-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer J. 2004 Nov-Dec;10(6):386-90 [15701271] Int J Radiat Oncol Biol Phys. 2006 May 1;65(1):1-7 [16618572] Int J Radiat Oncol Biol Phys. 2005 Oct 1;63(2):362-72 [16168831] Br J Radiol. 2005 Jun;78(930):548-52 [15900062] Int J Radiat Oncol Biol Phys. 1999 Aug 1;45(1):137-45 [10477017] Radiographics. 1999 Jul-Aug;19(4):873-85 [10464796] Int J Radiat Oncol Biol Phys. 2001 Jan 1;49(1):261-4 [11163523] J Appl Clin Med Phys. 2002 Autumn;3(4):310-6 [12383051] Int J Radiat Oncol Biol Phys. 2003 Jan 1;55(1):245-60 [12504059] Med Dosim. 2003 Spring;28(1):35-8 [12747617] Int J Radiat Oncol Biol Phys. 2004 Mar 1;58(3):727-34 [14967427] Radiology. 1975 Jan;114(1):155-62 [813276] Int J Radiat Oncol Biol Phys. 1997 Mar 15;37(5):1187-92 [9169830] Int J Radiat Oncol Biol Phys. 1999 Apr 1;44(1):81-4 [10219798] Eur J Cancer. 1998 Sep;34(10):1592-7 [9893634] Radiographics. 1998 Sep-Oct;18(5):1125-36; quiz 1242-3 [9747611] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis. AN - 68119705; 17559148 AB - A pilot study of a 48-week course of pioglitazone demonstrated significant improvements in the biochemical and histological features of nonalcoholic steatohepatitis (NASH). The aim of the study was to assess the effects of stopping pioglitazone. Twenty-one patients with NASH were treated with pioglitazone (30 mg/day) for 48 weeks and underwent baseline and end-of-treatment evaluation including liver biopsy. Thirteen patients were followed for at least 48 weeks after stopping therapy and 9 underwent repeat liver biopsy. Statistical comparisons were made to evaluate whether discontinuation of pioglitazone resulted in a reversal of improvements seen on therapy. Stopping pioglitazone was associated with subsequent elevation in serum alanine aminotransferase levels (from 34 +/- 13 to 70 +/- 39 IU/l), decrease in adiponectin (from 9.7 +/- 9.1 to 5.1 +/- 4.5 microg/ml), worsening insulin sensitivity (HOMA Index: from 2.9 +/- 1.8 to 5.5 +/- 5.4), and increase in total hepatic fat (from 30% +/- 32% to 71% +/- 33%) despite no change in average body weight compared to the end of treatment. Repeat liver biopsy in 9 patients revealed significant worsening of parenchymal inflammation (from 1.2 +/- 0.7 to 2.9 +/- 1.1) and steatosis (from 0.9 +/- 0.6 to 2.1 +/- 1.3) but no change in fibrosis (from 1.1 +/- 1.2 to 1.2 +/- 1.3). NASH was again present on liver biopsy in 7 patients. These findings suggest that long-term therapy with pioglitazone may be necessary to maintain improvements in disease activity in patients with NASH, although weight gain during treatment may ultimately limit its beneficial effects. JF - Hepatology (Baltimore, Md.) AU - Lutchman, Glen AU - Modi, Apurva AU - Kleiner, David E AU - Promrat, Kittichai AU - Heller, Theo AU - Ghany, Marc AU - Borg, Brian AU - Loomba, Rohit AU - Liang, T Jake AU - Premkumar, Ahalya AU - Hoofnagle, Jay H AD - Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 424 EP - 429 VL - 46 IS - 2 SN - 0270-9139, 0270-9139 KW - PPAR gamma KW - 0 KW - Thiazolidinediones KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - pioglitazone KW - X4OV71U42S KW - Index Medicus KW - Weight Gain -- drug effects KW - Aspartate Aminotransferases -- blood KW - Liver -- pathology KW - Alanine Transaminase -- blood KW - Humans KW - Adult KW - Middle Aged KW - Insulin Resistance KW - Male KW - Female KW - Fatty Liver -- drug therapy KW - Fatty Liver -- metabolism KW - Thiazolidinediones -- adverse effects KW - Fatty Liver -- pathology KW - Thiazolidinediones -- therapeutic use KW - PPAR gamma -- agonists UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68119705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=The+effects+of+discontinuing+pioglitazone+in+patients+with+nonalcoholic+steatohepatitis.&rft.au=Lutchman%2C+Glen%3BModi%2C+Apurva%3BKleiner%2C+David+E%3BPromrat%2C+Kittichai%3BHeller%2C+Theo%3BGhany%2C+Marc%3BBorg%2C+Brian%3BLoomba%2C+Rohit%3BLiang%2C+T+Jake%3BPremkumar%2C+Ahalya%3BHoofnagle%2C+Jay+H&rft.aulast=Lutchman&rft.aufirst=Glen&rft.date=2007-08-01&rft.volume=46&rft.issue=2&rft.spage=424&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-30 N1 - Date created - 2007-08-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Hepatology. 2007 Aug;46(2):285-7 [17661403] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In vitro models of TGF-beta-induced fibrosis suitable for high-throughput screening of antifibrotic agents. AN - 68109749; 17494090 AB - Progressive fibrosis is a cause of progressive organ dysfunction. Lack of quantitative in vitro models of fibrosis accounts, at least partially, for the slow progress in developing effective antifibrotic drugs. Here, we report two complementary in vitro models of fibrosis suitable for high-throughput screening. We found that, in mesangial cells and renal fibroblasts grown in eight-well chamber slides, transforming growth factor-beta1 (TGF-beta1) disrupted the cell monolayer and induced cell migration into nodules in a dose-, time- and Smad3-dependent manner. The nodules contained increased interstitial collagens and showed an increased collagen I:IV ratio. Nodules are likely a biological consequence of TGF-beta1-induced matrix overexpression since they were mimicked by addition of collagen I to the cell culture medium. TGF-beta1-induced nodule formation was inhibited by vacuum ionized gas treatment of the plate surface. This blockage was further enhanced by precoating plates with matrix proteins but was prevented, at least in part, by poly-l-lysine (PLL). We have established two cell-based models of TGF-beta-induced fibrogenesis, using mesangial cells or fibroblasts cultured in matrix protein or PLL-coated 96-well plates, on which TGF-beta1-induced two-dimensional matrix accumulation, three-dimensional nodule formation, and monolayer disruption can be quantitated either spectrophotometrically or by using a colony counter, respectively. As a proof of principle, chemical inhibitors of Alk5 and the antifibrotic compound tranilast were shown to have inhibitory activities in both assays. JF - American journal of physiology. Renal physiology AU - Xu, Qihe AU - Norman, Jill T AU - Shrivastav, Shashi AU - Lucio-Cazana, Javier AU - Kopp, Jeffrey B AD - Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Disases, National Institutes of Health, Bethesda, MD 20892-1268, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - F631 EP - F640 VL - 293 IS - 2 SN - 1931-857X, 1931-857X KW - Coloring Agents KW - 0 KW - Smad3 Protein KW - Transforming Growth Factor beta KW - Polylysine KW - 25104-18-1 KW - Index Medicus KW - Animals KW - Fibroblasts -- drug effects KW - Humans KW - Mice KW - Mesenchymal Stromal Cells -- drug effects KW - Epithelial Cells -- drug effects KW - Fibroblasts -- pathology KW - Polylysine -- pharmacology KW - Cells, Cultured KW - Glomerular Mesangium -- cytology KW - Glomerular Mesangium -- drug effects KW - Kidney -- cytology KW - Dogs KW - Microscopy, Electron KW - Smad3 Protein -- physiology KW - Image Processing, Computer-Assisted KW - Drug Evaluation, Preclinical KW - Cell Line KW - Fibrosis -- pathology KW - Fibrosis -- chemically induced KW - Transforming Growth Factor beta -- toxicity KW - Fibrosis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68109749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Renal+physiology&rft.atitle=In+vitro+models+of+TGF-beta-induced+fibrosis+suitable+for+high-throughput+screening+of+antifibrotic+agents.&rft.au=Xu%2C+Qihe%3BNorman%2C+Jill+T%3BShrivastav%2C+Shashi%3BLucio-Cazana%2C+Javier%3BKopp%2C+Jeffrey+B&rft.aulast=Xu&rft.aufirst=Qihe&rft.date=2007-08-01&rft.volume=293&rft.issue=2&rft.spage=F631&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Renal+physiology&rft.issn=1931857X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-26 N1 - Date created - 2007-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The impact of sex and sex hormones on lung physiology and disease: lessons from animal studies. AN - 68109628; 17575008 AB - Numerous animal studies have revealed significant effects of sex and sex hormones on normal lung development, lung physiology, and various lung diseases. The primary goal of this review is to summarize knowledge to date on the effects of sex and sex hormones on lung development, physiology, and disease in animals. Specific emphasis will be placed on fibrosis, allergic airway disease, acute lung injury models, respiratory infection, and lung toxicology studies. JF - American journal of physiology. Lung cellular and molecular physiology AU - Carey, Michelle A AU - Card, Jeffrey W AU - Voltz, James W AU - Germolec, Dori R AU - Korach, Kenneth S AU - Zeldin, Darryl C AD - National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - L272 EP - L278 VL - 293 IS - 2 SN - 1040-0605, 1040-0605 KW - Androgens KW - 0 KW - Estrogens KW - Index Medicus KW - Animals KW - Sex Characteristics KW - Androgens -- physiology KW - Lung Diseases -- physiopathology KW - Estrogens -- physiology KW - Lung -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68109628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Lung+cellular+and+molecular+physiology&rft.atitle=The+impact+of+sex+and+sex+hormones+on+lung+physiology+and+disease%3A+lessons+from+animal+studies.&rft.au=Carey%2C+Michelle+A%3BCard%2C+Jeffrey+W%3BVoltz%2C+James+W%3BGermolec%2C+Dori+R%3BKorach%2C+Kenneth+S%3BZeldin%2C+Darryl+C&rft.aulast=Carey&rft.aufirst=Michelle&rft.date=2007-08-01&rft.volume=293&rft.issue=2&rft.spage=L272&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Lung+cellular+and+molecular+physiology&rft.issn=10400605&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-26 N1 - Date created - 2007-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of aromatic and charged ectodomain residues in the P2X(4) receptor functions. AN - 68108105; 17663752 AB - The localization of ATP binding site(s) at P2X receptors and the molecular rearrangements associated with opening and closing of channels are still not well understood. At P2X(4) receptor, substitution of the K67, F185, K190, F230, R278, D280, R295, and K313 ectodomain residues with alanine generated low or non-responsive mutants, whereas the F294A mutant was functional. The loss of receptor function was also observed in K67R, R295K, and K313R mutants, but not in F185W, K190R, F230W, R278K, and D280E mutants. To examine whether the loss of function reflects decreased sensitivity of mutants for ATP, we treated cells with ivermectin, an antiparasitic agent that enhances responsiveness of P2X(4)R. In the presence of ivermectin, all low or non-responsive mutants responded to ATP in a dose-dependent manner, with the EC(50) values for ATP of about 1, 2, 4, 20, 60, 125, 270, 420, 1000 and 2300 micromol/L at D280A, R278A, F185A, K190A, R295K, K313R, R295A, K313A, K67A and K67R mutants, respectively. These results indicate that lysines 67 and 313 and arginine 295 play a critical role in forming the proper three-dimensional structure of P2X(4)R for agonist binding and/or channel gating. JF - Journal of neurochemistry AU - Zemkova, Hana AU - Yan, Zonghe AU - Liang, Zhaodong AU - Jelinkova, Irena AU - Tomic, Melanija AU - Stojilkovic, Stanko S AD - Section on Cellular Signaling, NICHD, National Institutes of Health, Bethesda, Maryland 20892-4510, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1139 EP - 1150 VL - 102 IS - 4 SN - 0022-3042, 0022-3042 KW - Amino Acids, Aromatic KW - 0 KW - P2RX4 protein, human KW - P2rx4 protein, mouse KW - Receptors, Purinergic P2 KW - Receptors, Purinergic P2X4 KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Ivermectin KW - 70288-86-7 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Index Medicus KW - Animals KW - Membrane Potentials -- radiation effects KW - Neurons -- metabolism KW - Ivermectin -- pharmacology KW - Dose-Response Relationship, Drug KW - Humans KW - Hypothalamus -- cytology KW - Mice KW - Structure-Activity Relationship KW - Gonadotropin-Releasing Hormone -- metabolism KW - Patch-Clamp Techniques KW - Transfection KW - Protein Binding -- drug effects KW - Mutagenesis, Site-Directed -- methods KW - Binding Sites -- drug effects KW - Membrane Potentials -- drug effects KW - Cell Line, Transformed KW - Adenosine Triphosphate -- pharmacology KW - Receptors, Purinergic P2 -- chemistry KW - Amino Acids, Aromatic -- physiology KW - Receptors, Purinergic P2 -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68108105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Role+of+aromatic+and+charged+ectodomain+residues+in+the+P2X%284%29+receptor+functions.&rft.au=Zemkova%2C+Hana%3BYan%2C+Zonghe%3BLiang%2C+Zhaodong%3BJelinkova%2C+Irena%3BTomic%2C+Melanija%3BStojilkovic%2C+Stanko+S&rft.aulast=Zemkova&rft.aufirst=Hana&rft.date=2007-08-01&rft.volume=102&rft.issue=4&rft.spage=1139&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-04 N1 - Date created - 2007-07-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A proposed COX-2 and PGE(2) receptor interaction in UV-exposed mouse skin. AN - 68108047; 17570497 AB - The cyclooxygenases (COX-1 and COX-2) and the prostaglandins (PGs) they generate play a major role in the skin's response to sunlight. Sunlight, especially the ultraviolet B (UVB) component, induces COX-2 and increases PG levels. However, PGs can have both beneficial and adverse cutaneous effects. To elucidate the roles of the COXs and the PGs they generate in response to UVB exposure, experiments with the COX-1- and COX-2-deficient mice have provided insight into the specific roles of each isoform. Furthermore, because PGE(2) is the major PG produced following UV exposure and PGE(2) manifests its biological activity via four membrane receptors (EP1, EP2, EP3, EP4), elucidating contributions of these receptors is essential for understanding the roles of PGs in UVB-induced effects. In this review, we summarize recent findings from the COX-deficient mice showing how COX-2 generated PGE(2) acting via the receptors EP2 and EP4 could contribute to short term beneficial, but also contribute to long-term carcinogenic effects in response to UVB exposure. JF - Molecular carcinogenesis AU - Chun, Kyung-Soo AU - Langenbach, Robert AD - Laboratory of Molecular Carcinogenesis, NIEHS, NIH, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 699 EP - 704 VL - 46 IS - 8 SN - 0899-1987, 0899-1987 KW - Receptors, Prostaglandin E KW - 0 KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - Index Medicus KW - Animals KW - Mice KW - Receptors, Prostaglandin E -- metabolism KW - Ultraviolet Rays KW - Skin -- radiation effects KW - Skin -- enzymology KW - Cyclooxygenase 2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68108047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=A+proposed+COX-2+and+PGE%282%29+receptor+interaction+in+UV-exposed+mouse+skin.&rft.au=Chun%2C+Kyung-Soo%3BLangenbach%2C+Robert&rft.aulast=Chun&rft.aufirst=Kyung-Soo&rft.date=2007-08-01&rft.volume=46&rft.issue=8&rft.spage=699&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=08991987&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-18 N1 - Date created - 2007-07-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Site matters: multisite randomized trial of motivational enhancement therapy in community drug abuse clinics. AN - 68107630; 17663610 AB - The effectiveness of motivational enhancement therapy (MET) in comparison with counseling as usual (CAU) for increasing retention and reducing substance use was evaluated in a multisite randomized clinical trial. Participants were 461 outpatients treated by 31 therapists within 1 of 5 outpatient substance abuse programs. There were no retention differences between the 2 brief intervention conditions. Although both 3-session interventions resulted in reductions in substance use during the 4-week therapy phase, MET resulted in sustained reductions during the subsequent 12 weeks whereas CAU was associated with significant increases in substance use over this follow-up period. This finding was complicated by program site main effects and higher level interactions. MET resulted in more sustained substance use reductions than CAU among primary alcohol users, but no difference was found for primary drug users. An independent evaluation of session audiotapes indicated that MET and CAU were highly and comparably discriminable across sites. JF - Journal of consulting and clinical psychology AU - Ball, Samuel A AU - Martino, Steve AU - Nich, Charla AU - Frankforter, Tami L AU - Van Horn, Deborah AU - Crits-Christoph, Paul AU - Woody, George E AU - Obert, Jeanne L AU - Farentinos, Christiane AU - Carroll, Kathleen M AU - National Institute on Drug Abuse Clinical Trials Network AD - Department of Psychiatry, Yale University School of Medicine, APT Foundation, New Haven, CT 06511, USA. samuel.ball@yale.edu ; National Institute on Drug Abuse Clinical Trials Network Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 556 EP - 567 VL - 75 IS - 4 SN - 0022-006X, 0022-006X KW - Index Medicus KW - Humans KW - Adult KW - Follow-Up Studies KW - Retention (Psychology) KW - Male KW - Female KW - Motivation KW - Community Mental Health Services -- utilization KW - Ambulatory Care Facilities KW - Substance-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68107630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+consulting+and+clinical+psychology&rft.atitle=Site+matters%3A+multisite+randomized+trial+of+motivational+enhancement+therapy+in+community+drug+abuse+clinics.&rft.au=Ball%2C+Samuel+A%3BMartino%2C+Steve%3BNich%2C+Charla%3BFrankforter%2C+Tami+L%3BVan+Horn%2C+Deborah%3BCrits-Christoph%2C+Paul%3BWoody%2C+George+E%3BObert%2C+Jeanne+L%3BFarentinos%2C+Christiane%3BCarroll%2C+Kathleen+M%3BNational+Institute+on+Drug+Abuse+Clinical+Trials+Network&rft.aulast=Ball&rft.aufirst=Samuel&rft.date=2007-08-01&rft.volume=75&rft.issue=4&rft.spage=556&rft.isbn=&rft.btitle=&rft.title=Journal+of+consulting+and+clinical+psychology&rft.issn=0022006X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-25 N1 - Date created - 2007-07-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Drug Alcohol Depend. 2000 Jan 1;57(3):225-38 [10661673] Drug Alcohol Depend. 2000 Apr 1;59(1):63-75 [10706976] J Consult Clin Psychol. 2000 Feb;68(1):134-44 [10710848] J Consult Clin Psychol. 2000 Oct;68(5):898-908 [11068976] Addiction. 2001 Aug;96(8):1149-60 [11487421] J Consult Clin Psychol. 2001 Oct;69(5):858-62 [11680565] Addiction. 2001 Dec;96(12):1725-42 [11784466] J Subst Abuse Treat. 2002 Dec;23(4):309-18 [12495792] J Subst Abuse Treat. 2003 Jan;24(1):51-7 [12646330] J Subst Abuse Treat. 2003 Apr;24(3):183-96 [12810139] J Consult Clin Psychol. 2003 Aug;71(4):754-63 [12924680] J Consult Clin Psychol. 2003 Oct;71(5):843-61 [14516234] Psychol Methods. 2003 Dec;8(4):518-23 [14664686] Drug Alcohol Depend. 2004 Jan 7;73(1):99-106 [14687964] Arch Gen Psychiatry. 2004 Mar;61(3):264-72 [14993114] Addiction. 2004 Jul;99(7):862-74 [15200582] J Consult Clin Psychol. 2004 Jun;72(3):455-66 [15279529] J Nerv Ment Dis. 1992 Feb;180(2):101-10 [1737971] J Stud Alcohol Suppl. 1994 Dec;12:149-55 [7722991] J Stud Alcohol Suppl. 1994 Dec;12:70-5 [7723001] Addiction. 1995 Mar;90(3):415-24 [7735025] J Stud Alcohol. 1997 Jan;58(1):7-29 [8979210] Arch Gen Psychiatry. 1997 Aug;54(8):721-6 [9283507] Public Health Rep. 1998 Jun;113 Suppl 1:116-28 [9722817] J Consult Clin Psychol. 2004 Dec;72(6):1050-62 [15612851] BMJ. 2005 Sep 10;331(7516):541 [16150764] Drug Alcohol Depend. 2006 Feb 28;81(3):301-12 [16169159] Addiction. 2006 Oct;101(10):1479-92 [16968350] Drug Alcohol Depend. 2007 Mar 16;87(2-3):107-18 [17023123] Annu Rev Clin Psychol. 2005;1:91-111 [17716083] Erratum In: J Consult Clin Psychol. 2009 Apr;77(2):336 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Impact of continuous versus intermittent CS-UCS pairing on human brain activation during Pavlovian fear conditioning. AN - 68106364; 17663589 AB - During Pavlovian fear conditioning a conditioned stimulus (CS) is repeatedly paired with an aversive unconditioned stimulus (UCS). In many studies the CS and UCS are paired on every trial, whereas in others the CS and UCS are paired intermittently. To better understand the influence of the CS-UCS pairing rate on brain activity, the experimenters presented continuously, intermittently, and non-paired CSs during fear conditioning. Amygdala, anterior cingulate, and fusiform gyrus activity increased linearly with the CS-UCS pairing rate. In contrast, insula and left dorsolateral prefrontal cortex responses were larger during intermittently paired CS presentations relative to continuously and non-paired CSs. These results demonstrate two distinct patterns of activity in disparate brain regions. Amygdala, anterior cingulate, and fusiform gyrus activity paralleled the CS-UCS pairing rate, whereas the insula and dorsolateral prefrontal cortex appeared to respond to the uncertainty inherent in intermittent CS-UCS pairing procedures. These findings may further clarify the role of these brain regions in Pavlovian fear conditioning. ((c) 2007 APA, all rights reserved). JF - Behavioral neuroscience AU - Dunsmoor, Joseph E AU - Bandettini, Peter A AU - Knight, David C AD - Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, 10 Center Drive, Bethesda, MD 20892, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 635 EP - 642 VL - 121 IS - 4 SN - 0735-7044, 0735-7044 KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Analysis of Variance KW - Area Under Curve KW - Humans KW - Dose-Response Relationship, Radiation KW - Brain Mapping KW - Magnetic Resonance Imaging -- methods KW - Oxygen -- blood KW - Adult KW - Middle Aged KW - Acoustic Stimulation KW - Time Factors KW - Image Processing, Computer-Assisted KW - Male KW - Female KW - Functional Laterality KW - Galvanic Skin Response -- physiology KW - Conditioning, Classical -- physiology KW - Fear KW - Brain -- blood supply KW - Brain -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68106364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+neuroscience&rft.atitle=Impact+of+continuous+versus+intermittent+CS-UCS+pairing+on+human+brain+activation+during+Pavlovian+fear+conditioning.&rft.au=Dunsmoor%2C+Joseph+E%3BBandettini%2C+Peter+A%3BKnight%2C+David+C&rft.aulast=Dunsmoor&rft.aufirst=Joseph&rft.date=2007-08-01&rft.volume=121&rft.issue=4&rft.spage=635&rft.isbn=&rft.btitle=&rft.title=Behavioral+neuroscience&rft.issn=07357044&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-12 N1 - Date created - 2007-07-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A key role for corticotropin-releasing factor in alcohol dependence. AN - 68106186; 17629579 AB - Recent data indicate that alcohol dependence induces long-term neuroadaptations that recruit a negative emotional state. This leads to excessive alcohol ingestion motivated by relief of negative emotionality. A key mechanism in this transition to negative reinforcement is a recruitment of corticotropin-releasing factor (CRF) signaling within the amygdala. Long term upregulation of CRF(1) receptors is observed in the amygdala following a history of dependence, and CRF antagonists selectively block emotionality, excessive alcohol drinking and stress-induced reinstatement of alcohol-seeking in post-dependent animals. Innate upregulation of CRF(1) receptor expression mimics the post-dependent phenotype, both with regard to emotional responses and ethanol self-administration. Therefore, the CRF system is emerging as a key element of the neuroadaptive changes driving alcoholism and as a major target for its treatment. JF - Trends in neurosciences AU - Heilig, Markus AU - Koob, George F AD - Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism (NIAAA), NIH, 10 Center Dr., 1/5334, Bethesda, MD 20892, USA. markus.heilig@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 399 EP - 406 VL - 30 IS - 8 SN - 0166-2236, 0166-2236 KW - Ethanol KW - 3K9958V90M KW - Corticotropin-Releasing Hormone KW - 9015-71-8 KW - Index Medicus KW - Animals KW - Adaptation, Physiological -- drug effects KW - Reward KW - Ethanol -- pharmacology KW - Humans KW - Amygdala -- metabolism KW - Affect -- drug effects KW - Affect -- physiology KW - Alcohol-Related Disorders -- metabolism KW - Behavior, Addictive -- metabolism KW - Corticotropin-Releasing Hormone -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68106186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+neurosciences&rft.atitle=A+key+role+for+corticotropin-releasing+factor+in+alcohol+dependence.&rft.au=Heilig%2C+Markus%3BKoob%2C+George+F&rft.aulast=Heilig&rft.aufirst=Markus&rft.date=2007-08-01&rft.volume=30&rft.issue=8&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=Trends+in+neurosciences&rft.issn=01662236&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-06 N1 - Date created - 2007-07-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuroscience. 2006;138(1):235-43 [16359808] Alcohol Clin Exp Res. 2006 May;30(5):908-15 [16634861] Mol Psychiatry. 2006 Jun;11(6):594-602 [16550213] Pharmacol Ther. 2006 Sep;111(3):855-76 [16545872] Addict Biol. 2006 Sep;11(3-4):339-55 [16961763] Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15236-41 [17015825] Alcohol Clin Exp Res. 2002 Aug;26(8):1259-68 [12198403] J Neurosci. 2002 Sep 15;22(18):7844-9 [12223536] J Neurosci. 2002 Sep 15;22(18):7856-61 [12223538] Alcohol Clin Exp Res. 2002 Oct;26(10):1494-501 [12394282] Lancet. 2002 Nov 2;360(9343):1347-60 [12423980] Alcohol Alcohol. 2003 Jan-Feb;38(1):35-9 [12554605] Alcohol. 2003 Feb;29(2):55-60 [12782246] Neurosci Biobehav Rev. 2003 May;27(3):189-97 [12788332] Psychopharmacology (Berl). 2003 Jul;168(1-2):3-20 [12402102] J Stud Alcohol. 2003 Jul;64(4):445-9 [12921185] Pharmacol Biochem Behav. 2004 Feb;77(2):405-13 [14751471] J Neurosci. 2004 Feb 18;24(7):1551-60 [14973230] Alcohol. 2004 Feb;32(2):101-11 [15163561] Trends Mol Med. 2004 Aug;10(8):409-15 [15310462] Pediatrics. 2004 Sep;114(3):714-9 [15342844] J Stud Alcohol. 2004 Jul;65(4):477-88 [15378804] J Pharmacol Exp Ther. 2004 Nov;311(2):427-40 [15297468] Science. 1981 Sep 18;213(4514):1394-7 [6267699] Neuroendocrinology. 1983;36(3):165-86 [6601247] Science. 1984 Sep 21;225(4668):1326-34 [6147896] Am Psychol. 1986 Jul;41(7):765-82 [3527003] Psychopharmacology (Berl). 1991;103(2):227-32 [2027923] Brain Res. 1993 Mar 5;605(1):25-32 [8467387] Trends Neurosci. 1994 Feb;17(2):80-5 [7512773] J Neurosci. 1995 Aug;15(8):5439-47 [7643193] Neuron. 1996 Mar;16(3):675-86 [8785064] Psychopharmacology (Berl). 1998 Jan;135(2):169-74 [9497022] Neuropsychopharmacology. 1999 May;20(5):471-9 [10192827] Acta Psychiatr Neurol Scand Suppl. 1951;70:1-283 [14837769] Alcohol Clin Exp Res. 2004 Nov;28(11):1676-82 [15547454] Alcohol Clin Exp Res. 2004 Dec;28(12):1829-38 [15608599] Neurosci Lett. 2005 Feb 28;375(2):129-33 [15670655] Nat Rev Drug Discov. 2005 Feb;4(2):131-44 [15665858] Psychopharmacology (Berl). 2005 Apr;178(4):367-80 [15765253] Psychopharmacology (Berl). 2005 May;179(2):366-73 [15551068] Alcohol Clin Exp Res. 2005 Apr;29(4):584-90 [15834223] Behav Brain Res. 2005 Jun 3;161(1):133-40 [15904720] J Neurosci. 2005 Jun 1;25(22):5389-96 [15930388] Nat Rev Genet. 2005 Jul;6(7):521-32 [15995696] Neuropsychopharmacology. 2005 Sep;30(9):1662-9 [15726114] Nat Neurosci. 2005 Nov;8(11):1431-6 [16251982] Nat Neurosci. 2005 Nov;8(11):1442-4 [16251985] Addict Biol. 2005 Dec;10(4):309-19 [16318951] EXS. 2006;(95):183-92 [16383007] Neuropsychopharmacology. 2000 Feb;22(2):108-24 [10649824] Neuropsychopharmacology. 2000 Jun;22(6):581-94 [10788758] Psychopharmacology (Berl). 2000 Jun;150(3):317-24 [10923760] Neuropsychopharmacology. 2001 Feb;24(2):97-129 [11120394] J Neurosci. 2006 Nov 1;26(44):11324-32 [17079660] Biol Psychiatry. 2007 Jan 1;61(1):78-86 [16876134] J Neurosci. 2007 Mar 7;27(10):2718-26 [17344409] Addict Biol. 2007 Mar;12(1):30-4 [17407495] Biol Psychiatry. 2008 Jan 15;63(2):139-45 [17585886] Behav Neural Biol. 1979 Dec;27(4):466-86 [575037] Psychopharmacology (Berl). 2001 Dec;158(4):374-81 [11797058] Trends Pharmacol Sci. 2002 Feb;23(2):71-7 [11830263] Pharmacol Biochem Behav. 2002 May;72(1-2):213-20 [11900791] J Pharmacol Exp Ther. 2002 Apr;301(1):322-32 [11907190] J Pharmacol Exp Ther. 2002 Apr;301(1):333-45 [11907191] Science. 2002 May 3;296(5569):931-3 [11988580] Pharmacol Biochem Behav. 2002 Aug;73(1):147-58 [12076734] Peptides. 2001 Mar;22(3):515-22 [11287109] Pharmacol Rev. 2001 Jun;53(2):209-43 [11356984] FASEB J. 2002 Jan;16(1):27-35 [11772933] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Future of molecular profiling of human hepatocellular carcinoma. AN - 68101934; 17661718 AB - Hepatocellular carcinoma (HCC) is a fatal disease occurring worldwide and developing mainly in chronic liver diseased patients. Despite routine screening of individuals at high risk, most of the patients are diagnosed at late stages of HCC. In addition, the recurrence rate after surgical resection of small tumors is high. Molecular profiling, including expression analysis, comparative genomics and proteomics, provides powerful tools to gain insight into the molecular mechanisms underlying carcinogenesis. Advances in bioinformatics have also allowed for the evaluation of large data sets. Therefore, molecular profiling of HCC using a Biological Expression Network Discovery (BLEND) strategy that integrates global molecular profiling data, including mRNA, miRNA, DNA methylation and DNA copy numbers from both the tumor and the surrounding microenvironment, along with mechanistic studies, may improve the diagnosis, treatment and prognosis of HCC patients. Such an approach will provide mechanistic insight into the pathogenesis of HCC, potentially leading to personalized medicine and the identification of new therapeutic targets. JF - Future oncology (London, England) AU - Roessler, Stephanie AU - Budhu, Anuradha AU - Wang, Xin Wei AD - National Cancer Institute, Laboratory of Human Carcinogenesis, Center for Cancer Research, NIH, 37 Convent Drive, Bldg. 37, Rm. 3044A, Bethesda, MD 20892-4258, USA. roesslst@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 429 EP - 439 VL - 3 IS - 4 SN - 1479-6694, 1479-6694 KW - Biomarkers, Tumor KW - 0 KW - Index Medicus KW - Liver Diseases -- complications KW - Humans KW - Prognosis KW - Gene Expression Profiling KW - Carcinoma, Hepatocellular -- etiology KW - Carcinoma, Hepatocellular -- diagnosis KW - Carcinoma, Hepatocellular -- genetics KW - Carcinoma, Hepatocellular -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68101934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Future+oncology+%28London%2C+England%29&rft.atitle=Future+of+molecular+profiling+of+human+hepatocellular+carcinoma.&rft.au=Roessler%2C+Stephanie%3BBudhu%2C+Anuradha%3BWang%2C+Xin+Wei&rft.aulast=Roessler&rft.aufirst=Stephanie&rft.date=2007-08-01&rft.volume=3&rft.issue=4&rft.spage=429&rft.isbn=&rft.btitle=&rft.title=Future+oncology+%28London%2C+England%29&rft.issn=14796694&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-25 N1 - Date created - 2007-07-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Recommended Newborn Screening Policy Change for the NICU Infant AN - 57237803; 200813214 AB - Newborn screening (NBS), the practice by which infants are tested for certain genetic and metabolic conditions by heel prick 3 to 5 days after birth, has been a beneficial and cost-effective public health strategy. Many of the screened conditions present in the first 2 weeks of life and are life threatening. Because of the risk of metabolic acidosis, seizures, coma, neurological devastation, or death, NBS is essential for prompt diagnosis and treatment, including dietary, hormonal, and other interventions. However, due to the fact that aminoglycosides, blood transfusions, nothing by mouth status, and the presence of heparinized solutions all potentially affect the screening results, NBS guidelines in neonatal intensive care units (NICUs) ought to be changed to obviate inaccurate results. These guidelines, originally initiated by nurses at the Johns Hopkins NICU due to the missed diagnosis and death of an infant, include screening the day of birth prior to any interventions, performing the screen at 1 and/or 2 weeks of life, and repeating screening as needed. [Copyright 2007 Sage Publications, Inc.] JF - Policy, Politics, & Nursing Practice AU - Balk, Katherine G AD - Johns Hopkins University, National Institutes of Health Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 210 EP - 219 PB - Sage Publications VL - 8 IS - 3 SN - 1527-1544, 1527-1544 KW - Screening KW - Intensive care units KW - Guidelines KW - Newborn babies KW - Health policy KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57237803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Policy%2C+Politics%2C+%26+Nursing+Practice&rft.atitle=Recommended+Newborn+Screening+Policy+Change+for+the+NICU+Infant&rft.au=Balk%2C+Katherine+G&rft.aulast=Balk&rft.aufirst=Katherine&rft.date=2007-08-01&rft.volume=8&rft.issue=3&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Policy%2C+Politics%2C+%26+Nursing+Practice&rft.issn=15271544&rft_id=info:doi/10.1177%2F1527154407309049 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-27 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Newborn babies; Screening; Health policy; Intensive care units; Guidelines DO - http://dx.doi.org/10.1177/1527154407309049 ER - TY - JOUR T1 - Frontal release signs and cognition in people with schizophrenia, their siblings and healthy controls AN - 57232064; 200804334 AB - Background Frontal release signs, a subset of neurological soft signs, are common in schizophrenia. Aims To explore the relationship between frontal release signs and neuropsychological tests of frontal lobe function in people with schizophrenia, their siblings and healthy controls. Method Neuropsychological tests and frontal release signs were measured in a cohort of index cases (n=302), their siblings (n=240) and healthy controls (n=346). Results The mean total score of frontal release signs was 1.5(s.d.=1.58)in the schizophrenia group, 0.54 (s.d. =0.92) for siblings and 0.42 (s.d. =0.77) for controls. Schizophrenia group scores were greater than healthy control or sibling cohort scores (P<0.0001), which did not differ. In all three cohorts, right grasp reflex scores positively correlated with number of perseverative errors on the Wisconsin Card Sort Task (P <0.05). In the schizophrenia group, frontal release signs scores showed an inverse correlation with IQ(R=-0.199, P<0.0005). Conclusions Our findings of relationships between frontal release signs and cognitive assays of cortical dysfunction and the increased frequency of these signs in people with schizophrenia implicate a cortical origin for these clinical signs and evidence of frontal lobe dysfunction in this disorder. Declaration of interest None. Adapted from the source document. JF - The British Journal of Psychiatry AU - Hyde, Thomas M AU - Goldberg, Terry E AU - Egan, Michael F AU - Lener, Marc C AU - Weinberger, Daniel R AD - Room 4N306, Building 10, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892.USA. Tel: + 1 301 496 8848, fax: +1 301 402 2751 Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 120 EP - 125 PB - Royal College of Psychiatrists, London UK VL - 191 SN - 0007-1250, 0007-1250 KW - Frontal lobes KW - Schizophrenia KW - Neuropsychological tests KW - Siblings KW - Cognition KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57232064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+Journal+of+Psychiatry&rft.atitle=Frontal+release+signs+and+cognition+in+people+with+schizophrenia%2C+their+siblings+and+healthy+controls&rft.au=Hyde%2C+Thomas+M%3BGoldberg%2C+Terry+E%3BEgan%2C+Michael+F%3BLener%2C+Marc+C%3BWeinberger%2C+Daniel+R&rft.aulast=Hyde&rft.aufirst=Thomas&rft.date=2007-08-01&rft.volume=191&rft.issue=&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=The+British+Journal+of+Psychiatry&rft.issn=00071250&rft_id=info:doi/10.1192%2Fbjp.bp.106.026773 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-03-04 N1 - Last updated - 2016-09-27 N1 - CODEN - BJPYAJ N1 - SubjectsTermNotLitGenreText - Schizophrenia; Frontal lobes; Siblings; Neuropsychological tests; Cognition DO - http://dx.doi.org/10.1192/bjp.bp.106.026773 ER - TY - JOUR T1 - Migraine headaches are not associated with a unique depressive symptom profile: Results from the Baltimore Epidemiologic Catchment Area Study AN - 57227601; 200807068 AB - Objective: There is a well-established link between migraine headaches and depression. However, it is unclear whether individuals with migraine experience a unique profile of depressive symptoms in comparison to individuals without migraine. Methods: This question was addressed using data from the Baltimore cohort of the Epidemiologic Catchment Area Study. The cross-sectional association between migraine headaches and each depressive symptom was calculated using logistic regression, and symptom profiles among those with migraine headaches (n=249) and those without (n=1480) were compared using generalized estimating equations. Results: Migraine headaches were associated with increased odds of reporting seven of nine depressive symptom groups by a factor of roughly 2. However, when the symptom profiles were compared, individuals with migraine headaches did not differ in their profile of symptoms. Conclusion: These results suggest that individuals with migraine headaches are more likely to report depressive symptoms but do not display a unique profile of symptoms. [Copyright 2007 Elsevier Inc.] JF - Journal of Psychosomatic Research AU - Kalaydjian, Amanda AU - Eaton, William AU - Zandi, Peter AD - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA kalaydjiana@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 123 EP - 129 PB - Elsevier Science Inc. VL - 63 IS - 2 SN - 0022-3999, 0022-3999 KW - Depression KW - Headache KW - Migraine KW - Symptoms KW - Suicide KW - Severity KW - Physical symptoms KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57227601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychosomatic+Research&rft.atitle=Migraine+headaches+are+not+associated+with+a+unique+depressive+symptom+profile%3A+Results+from+the+Baltimore+Epidemiologic+Catchment+Area+Study&rft.au=Kalaydjian%2C+Amanda%3BEaton%2C+William%3BZandi%2C+Peter&rft.aulast=Kalaydjian&rft.aufirst=Amanda&rft.date=2007-08-01&rft.volume=63&rft.issue=2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychosomatic+Research&rft.issn=00223999&rft_id=info:doi/10.1016%2Fj.jpsychores.2007.03.005 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-04-02 N1 - Last updated - 2016-09-27 N1 - CODEN - JPCRAT N1 - SubjectsTermNotLitGenreText - Depression; Suicide; Migraine; Physical symptoms DO - http://dx.doi.org/10.1016/j.jpsychores.2007.03.005 ER - TY - JOUR T1 - A proposed stereo matching algorithm for noisy sets of color images AN - 50520415; 2009-021288 AB - Modeling the world in three dimensions has been attracting a growing interest both in applications and science. In many cases, such 3D models are achieved by triangulating corresponding features recorded by several images of the same field taken from different points of view. This, however, requires the ability to match corresponding image elements detected in different images. In this paper, an algorithm for stereo matching in noisy pairs of outdoor images is described. The proposed algorithm applies a standard window-based correlation, but uses a fuzzy logic-based similarity function that models the HSV color space. This fuzzy logic modeling allows a robust color comparison that can tolerate a certain degree of changes in the illumination conditions and can be used for finding corresponding pixels in noisy sets of images. While the proposed algorithm does not introduce an improvement over existing methods in ideal conditions, experiments suggest that it provides significantly better results when the images in the set are relatively different from each other, and can be effective for matching corresponding features in images taken in different weather conditions, different positions of the sun, different optics or other real-life situations in which pinhole conditions are not available. JF - Computers & Geosciences AU - Shamir, Lior Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1052 EP - 1063 PB - Elsevier, Amsterdam VL - 33 IS - 8 SN - 0098-3004, 0098-3004 KW - fuzzy logic KW - imagery KW - technology KW - three-dimensional models KW - stereographic projection KW - color KW - algorithms KW - remote sensing KW - 20:Applied geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50520415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computers+%26+Geosciences&rft.atitle=A+proposed+stereo+matching+algorithm+for+noisy+sets+of+color+images&rft.au=Shamir%2C+Lior&rft.aulast=Shamir&rft.aufirst=Lior&rft.date=2007-08-01&rft.volume=33&rft.issue=8&rft.spage=1052&rft.isbn=&rft.btitle=&rft.title=Computers+%26+Geosciences&rft.issn=00983004&rft_id=info:doi/10.1016%2Fj.cageo.2006.11.013 L2 - http://www.sciencedirect.com/science?_ob=JournalURL&_cdi=5840&_auth=y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=e5198452fad934c6346f38b57511c8e0 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2009-01-01 N1 - Number of references - 40 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - algorithms; color; fuzzy logic; imagery; remote sensing; stereographic projection; technology; three-dimensional models DO - http://dx.doi.org/10.1016/j.cageo.2006.11.013 ER - TY - JOUR T1 - Serotonergic influences on life-history outcomes in free-ranging male rhesus macaques AN - 36846510; 3526061 AB - Several studies have demonstrated that nonhuman primate males with low cerebrospinal fluid (CSF) levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) exhibit antisocial behavior patterns. Included in these deleterious patterns are impulse control deficits associated with violence and premature death. No studies to date have longitudinally studied the long-term outcome of young subjects with low CSF 5-HIAA concentrations as they mature into adults. In this study we examined longitudinal relations among serotonergic and dopaminergic functioning, as reflected in CSF metabolite concentrations, aggression, age at emigration, dominance rank, and mortality in free-ranging rhesus macaque (Macaca mulatta) males. Our results indicate long-term consistency of individual differences in levels of 5-HIAA in CSF in the subject population from the juvenile period of development through adulthood. We found a significant negative correlation between 5-HIAA concentrations measured in juveniles and rates of high-intensity aggression in the same animals as adults. Further, CSF 5-HIAA concentrations were lower in juveniles that died than in animals that survived. For the young animals that migrated there was a positive correlation between CSF 5-HIAA concentration and age at emigration, whereas for the animals that remained in their troop until later in sexual maturity there was a negative correlation between CSF 5-HIAA concentration and age of emigration. After animals emigrated to a new troop, social dominance rank in the new troop was positively correlated with early family social dominance rank, but inversely correlated with juvenile CSF 5-HIAA concentrations. Taken together, our findings suggest that males with low central serotonin levels early in life delay migration and show high levels of violence and premature death, but the males that survive achieve high rank. These findings indicate that longitudinal measures of serotonergic and dopaminergic functioning are predictive of major life-history outcomes in nonhuman primate males. Low concentrations of CSF 5-HIAA are associated with negative life-history patterns characterized by social instability and excessive aggression, and positive life-history patterns characterized by higher dominance rank. Copyright John Wiley & Sons. Reproduced with permission. An electronic version of this article is available online at http://www.interscience.wiley.com JF - American journal of primatology AU - Howell, Sue AU - Westergaard, Greg AU - Hoos, Beth AU - Chavanne, Tara J AU - Shoaf, Susan E AU - Cleveland, Allison AU - Snoy, Philip J AU - Suomi, Stephen J AU - Higley, J Dee AD - Division of Research and Development, Alpha Genesis, Inc., Yemassee ; Division of Research and Development, Alpha Genesis, Inc., Yemasee ; National Institute on Alcohol Abuse and Alcoholism ; Center for Biologics Evaluation and Research, Rockville ; National Institute of Child Health and Human Development Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 851 EP - 865 VL - 69 IS - 8 SN - 0275-2565, 0275-2565 KW - Anthropology KW - Macaques KW - Longitudinal studies KW - Mortality KW - Life history KW - Physical anthropology KW - Primatology KW - Primate behaviour KW - Migration KW - Hormones UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36846510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+primatology&rft.atitle=Serotonergic+influences+on+life-history+outcomes+in+free-ranging+male+rhesus+macaques&rft.au=Howell%2C+Sue%3BWestergaard%2C+Greg%3BHoos%2C+Beth%3BChavanne%2C+Tara+J%3BShoaf%2C+Susan+E%3BCleveland%2C+Allison%3BSnoy%2C+Philip+J%3BSuomi%2C+Stephen+J%3BHigley%2C+J+Dee&rft.aulast=Howell&rft.aufirst=Sue&rft.date=2007-08-01&rft.volume=69&rft.issue=8&rft.spage=851&rft.isbn=&rft.btitle=&rft.title=American+journal+of+primatology&rft.issn=02752565&rft_id=info:doi/10.1002%2Fajp.20369 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 9507 1077; 5983 9524 1615 8573 11325; 7541 7537 971; 8040; 7398 5889; 8291 3409 6306; 10144 10148 10149 1542 11325; 10149 DO - http://dx.doi.org/10.1002/ajp.20369 ER - TY - JOUR T1 - Methods for translating an English-language survey questionnaire on tobacco use into Mandarin, Cantonese, Korean, and Vietnamese AN - 36831315; 3519322 AB - This article reports research on procedures for translating a survey questionnaire on tobacco use from English into Mandarin Chinese, Cantonese Chinese, Korean, and Vietnamese. The goal is to offer practical guidelines for researchers involved in translating questionnaires. The authors operationalize a five-step process for translation and evaluation based on the frameworks presented in Harkness, Van de Vijver, and Mohler (2003) and the U.S. Census Bureau (2004). Based on qualitative observations, the five-step process produced effective questionnaire translations. The iterative nature of the process and the team-based approach the process encourages were particularly important to the success. Based on documented experiences, the authors identify lessons learned and make recommendations to other researchers who need to translate questionnaires. Reprinted by permission of Sage Publications Inc. JF - Field methods AU - Forsyth, Barbara H AU - Kudela, Martha Stapleton AU - Levin, Kerry AU - Lawrence, Deirdre AU - Willis, Gordon B AD - Westat, Rockville, Maryland ; National Cancer Institute Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 264 EP - 283 VL - 19 IS - 3 SN - 1525-822X, 1525-822X KW - Anthropology KW - Qualitative analysis KW - Evaluation KW - Translation KW - Questionnaires KW - Survey data KW - Tobacco KW - Anthropological research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36831315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Field+methods&rft.atitle=Methods+for+translating+an+English-language+survey+questionnaire+on+tobacco+use+into+Mandarin%2C+Cantonese%2C+Korean%2C+and+Vietnamese&rft.au=Forsyth%2C+Barbara+H%3BKudela%2C+Martha+Stapleton%3BLevin%2C+Kerry%3BLawrence%2C+Deirdre%3BWillis%2C+Gordon+B&rft.aulast=Forsyth&rft.aufirst=Barbara&rft.date=2007-08-01&rft.volume=19&rft.issue=3&rft.spage=264&rft.isbn=&rft.btitle=&rft.title=Field+methods&rft.issn=1525822X&rft_id=info:doi/10.1177%2F1525822X07302105 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1069 10902; 12427 12429; 10541; 12927 7239 7226; 12766 3055 798 10286; 4551; 10519 3279 971 3286 DO - http://dx.doi.org/10.1177/1525822X07302105 ER - TY - JOUR T1 - Prolonged survival in poor-risk diffuse large B-cell lymphoma following front-line treatment with rituximab-supplemented, early-intensified chemotherapy with multiple autologous hematopoietic stem cell support: a multicenter study by GITIL (Gruppo Italiano Terapie Innovative nei Linfomi) AN - 220536854; 17554382 AB - A prospective multicenter program was performed to evaluate the combination of rituximab and high-dose (hd) sequential chemotherapy delivered with multiple autologous peripheral blood progenitor cell (PBPC) support (R-HDS-maps regimen) in previously untreated patients with diffuse large B-cell lymphoma (DLB-CL) and age-adjusted International Prognostic Score (aaIPI) score 2-3. R-HDS-maps includes: (i) three APO courses; (ii) sequential administration of hd-cyclophosphamide (CY), hd-Ara-C, both supplemented with rituximab, hd-etoposide/cisplatin, PBPC harvests, following hd-CY and hd-Ara-C; (iii) hd-mitoxantrone (hd-Mito)/L-Pam + 2 further rituximab doses; (iv) involved-field radiotherapy. PBPC rescue was scheduled following Ara-C, etoposide/cisplatin and Mito/L-Pam. Between 1999 and 2004, 112 consecutive patients aged <65 years (74 score 2, 38 score 3) entered the study protocol. There were five early and two late toxic deaths. Overall 90 patients (80%) reached clinical remission (CR); at a median 48 months follow-up, 87 (78%) patients are alive, 82 (73%) in continuous CR, with 4 year overall survival (OS) and event-free survival (EFS) projections of 76% (CI 68-85%) and 73% (CI 64-81%), respectively. There were no significant differences in OS and EFS between subgroups with Germinal-Center and Activated B-cell phenotype. Thus, life expectancy of younger patients with aaIPI 2-3 DLB-CL is improved with the early administration of rituximab-supplemented intensive chemotherapy compared with the poor outcome following conventional chemotherapy. JF - Leukemia AU - Tarella, C AU - Zanni, M AU - M Di Nicola AU - Patti, C AU - Calvi, R AU - Pescarollo, A AU - Zoli, V AU - Fornari, A AU - Novero, D AU - Cabras, A AU - Stella, M AU - Comino, A AU - Remotti, D AU - Ponzoni, M AU - Caracciolo, D AU - Ladetto, M AU - Magni, M AU - Devizzi, L AU - Rosato, R AU - Boccadoro, M AU - Bregni, M AU - Corradini, P AU - Gallamini, A Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 1802 EP - 11 CY - London PB - Nature Publishing Group VL - 21 IS - 8 SN - 08876924 KW - Medical Sciences--Oncology KW - Antibodies, Monoclonal KW - Antibodies, Monoclonal, Murine-Derived KW - rituximab KW - Cytarabine KW - Etoposide KW - Cyclophosphamide KW - Mitoxantrone KW - Cisplatin KW - Melphalan KW - Cyclophosphamide -- administration & dosage KW - Disease-Free Survival KW - Combined Modality Therapy KW - Humans KW - Mitoxantrone -- administration & dosage KW - Cytarabine -- administration & dosage KW - Transplantation, Autologous KW - Antibodies, Monoclonal -- administration & dosage KW - Cisplatin -- administration & dosage KW - Feasibility Studies KW - Prospective Studies KW - Etoposide -- administration & dosage KW - Melphalan -- administration & dosage KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Peripheral Blood Stem Cell Transplantation KW - Lymphoma, B-Cell -- therapy KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Lymphoma, Large B-Cell, Diffuse -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/220536854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia&rft.atitle=Prolonged+survival+in+poor-risk+diffuse+large+B-cell+lymphoma+following+front-line+treatment+with+rituximab-supplemented%2C+early-intensified+chemotherapy+with+multiple+autologous+hematopoietic+stem+cell+support%3A+a+multicenter+study+by+GITIL+%28Gruppo+Italiano+Terapie+Innovative+nei+Linfomi%29&rft.au=Tarella%2C+C%3BZanni%2C+M%3BM+Di+Nicola%3BPatti%2C+C%3BCalvi%2C+R%3BPescarollo%2C+A%3BZoli%2C+V%3BFornari%2C+A%3BNovero%2C+D%3BCabras%2C+A%3BStella%2C+M%3BComino%2C+A%3BRemotti%2C+D%3BPonzoni%2C+M%3BCaracciolo%2C+D%3BLadetto%2C+M%3BMagni%2C+M%3BDevizzi%2C+L%3BRosato%2C+R%3BBoccadoro%2C+M%3BBregni%2C+M%3BCorradini%2C+P%3BGallamini%2C+A&rft.aulast=Tarella&rft.aufirst=C&rft.date=2007-08-01&rft.volume=21&rft.issue=8&rft.spage=1802&rft.isbn=&rft.btitle=&rft.title=Leukemia&rft.issn=08876924&rft_id=info:doi/10.1038%2Fsj.leu.2404781 LA - English DB - ProQuest Central N1 - Copyright - Copyright Nature Publishing Group Aug 2007 N1 - Last updated - 2014-03-30 DO - http://dx.doi.org/10.1038/sj.leu.2404781 ER - TY - JOUR T1 - The Bipolar Disorder Phenome Database: A Resource for Genetic Studies AN - 220471780; 17671286 AB - The purpose of this study was to assemble and validate a database of phenotypic variables that were collected from families with bipolar disorder as a resource for genetic and other biological studies. Participants were ascertained for two bipolar disorder genetic linkage studies: the University of Chicago, Johns Hopkins, and National Institute of Mental Health (NIMH) Intramural Program (CHIP) Collaboration and the NIMH Genetics Initiative project. All participants underwent detailed, phenotypic assessment with either the Schedule for Affective Disorders and Schizophrenia-Lifetime Version or one of four versions of the Diagnostic Interview for Genetic Studies. Clinicians reviewed the interview items and derived variable definitions that were used to extract data from the original datasets. The combined data were subjected to range and logic assessments, and a subset was re-verified against the original data Inconsistent data and variables that were deemed unreliable were excluded. Several of the resulting variables were characterized in the total cohort and tested for familial clustering, heritability, and statistical power in genetic linkage and association studies. The combined database of phenotypic variables contained 197 variables on 5,721 subjects in 1,177 families. Deoxyribonucleic acid (DNA) samples are available for 5,373 of these subjects. The clinical presentation of bipolar disorder varied markedly. Most subjects suffered from serious and often disabling illness. Many phenotypic variables are strongly familial, and some quantitative variables are highly heritable. The cohort assembled in this study offers substantial power to carry out genetic linkage and association studies that use specific clinical features as covariates or as primary phenotypes. This is the largest database of phenotypic variables yet assembled for bipolar disorder, and it is now available to the research community. Researchers and clinicians can use this database to explore the connections between phenomenology and genetics in a cohort that is adequately powered to detect even modest genetic effects in bipolar disorder. JF - The American Journal of Psychiatry AU - Potash, James B AU - Toolan, Jennifer AU - Steele, Jo AU - Miller, Erin B AU - et al Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 1229 EP - 37 CY - Washington PB - American Psychiatric Association VL - 164 IS - 8 SN - 0002953X KW - Medical Sciences--Psychiatry And Neurology KW - Schizophrenia KW - Studies KW - Alzheimers disease KW - Bipolar disorder KW - Genes KW - United States KW - Pedigree KW - Genetic Linkage KW - Genetic Variation KW - Reproducibility of Results KW - Humans KW - National Institute of Mental Health (U.S.) KW - Research Design KW - Chromosome Mapping KW - Comorbidity KW - Phenotype KW - Genotype KW - Genetic Testing KW - Genetic Predisposition to Disease -- genetics KW - Psychotic Disorders -- genetics KW - Adult KW - Cohort Studies KW - Female KW - Male KW - Genetic Research KW - Databases, Genetic -- statistics & numerical data KW - Bipolar Disorder -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/220471780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=The+Bipolar+Disorder+Phenome+Database%3A+A+Resource+for+Genetic+Studies&rft.au=Potash%2C+James+B%3BToolan%2C+Jennifer%3BSteele%2C+Jo%3BMiller%2C+Erin+B%3Bet+al&rft.aulast=Potash&rft.aufirst=James&rft.date=2007-08-01&rft.volume=164&rft.issue=8&rft.spage=1229&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Psychiatric Association Aug 2007 N1 - Document feature - Diagrams; Tables; References N1 - Last updated - 2013-02-10 N1 - CODEN - AJPSAO ER - TY - JOUR T1 - Computed Tomography Screening for Lung Cancer AN - 21244645; 7557205 JF - JAMA: Journal of the American Medical Association AU - Berg, Christine D AU - Aberle, Denise R AD - National Cancer Institute , Bethesda, Maryland , David Geffen School of Medicine at UCLA , Los Angeles, California, bergc@mail.nih.gov Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 513 EP - 514 PB - American Medical Association, 515 N. State St. Chicago IL 60610 USA VL - 298 IS - 5 SN - 0098-7484, 0098-7484 KW - Biotechnology and Bioengineering Abstracts KW - Computed tomography KW - Lung cancer KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21244645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA%3A+Journal+of+the+American+Medical+Association&rft.atitle=Computed+Tomography+Screening+for+Lung+Cancer&rft.au=Berg%2C+Christine+D%3BAberle%2C+Denise+R&rft.aulast=Berg&rft.aufirst=Christine&rft.date=2007-08-01&rft.volume=298&rft.issue=5&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=JAMA%3A+Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Computed tomography; Lung cancer ER - TY - JOUR T1 - Tonsil Epithelial Factors May Influence Oropharyngeal Human Immunodeficiency Virus Transmission AN - 21209314; 11653116 AB - Tonsil epithelium has been implicated in human immunodeficiency virus (HIV) pathogenesis, but its role in oral transmission remains controversial. To study characteristics of this tissue, which may influence susceptibility or resistance to HIV, we performed microarray analysis of the tonsil epithelium. Our data revealed that genes related to immune functions such as antibody production and antigen processing were increasingly expressed in tonsil compared with the epithelium of another oropharyngeal site, the gingival epithelium. Importantly, tonsil epithelium highly expressed genes associated with HIV entrapment and/or transmission, including the HIV co-receptor CXCR4 and the potential HIV-binding molecules FcRgIII, complement receptor 2, and various complement components. Immunohistochemical staining confirmed the increased presence of CXCR4 in the tonsil epithelium compared with multiple oral epithelial sites, particularly in basal and parabasal layers. This increased expression of molecules involved in viral recognition, binding, and entry may favor virus-epithelium interactions in an environment with reduced innate antiviral mechanisms. Specifically, secretory leukocyte protease inhibitor, an innate molecule with anti-HIV activity, was minimal in the tonsil epithelium, in contrast to oral mucosa. Collectively, our data suggest that increased expression of molecules associated with HIV binding and entry coupled with decreased innate antiviral factors may render the tonsil a potential site for oral transmission. JF - American Journal of Pathology AU - Moutsopoulos, N M AU - Nares, S AU - Nikitakis, N AU - Rangel, Z AU - Wen, J AU - Munson, P AU - Sauk, J AU - Wahl, S M AD - Oral Infection and Immunity Branch, Center for Information Technology, National Institutes of Health, Bethesda, USA Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 571 EP - 579 VL - 171 IS - 2 SN - 0002-9440, 0002-9440 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Data processing KW - CXCR4 protein KW - Leukocytes KW - Gingiva KW - Proteinase inhibitors KW - Mucosa KW - Antiviral activity KW - Disease transmission KW - Antibodies KW - Tonsil KW - Human immunodeficiency virus KW - complement receptor 2 KW - Antigen processing KW - Epithelium KW - Immune response KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21209314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Pathology&rft.atitle=Tonsil+Epithelial+Factors+May+Influence+Oropharyngeal+Human+Immunodeficiency+Virus+Transmission&rft.au=Moutsopoulos%2C+N+M%3BNares%2C+S%3BNikitakis%2C+N%3BRangel%2C+Z%3BWen%2C+J%3BMunson%2C+P%3BSauk%2C+J%3BWahl%2C+S+M&rft.aulast=Moutsopoulos&rft.aufirst=N&rft.date=2007-08-01&rft.volume=171&rft.issue=2&rft.spage=571&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Pathology&rft.issn=00029440&rft_id=info:doi/10.2353%2Fajpath.2007.061006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Data processing; CXCR4 protein; Mucosa; Proteinase inhibitors; Gingiva; Leukocytes; Antiviral activity; Disease transmission; Antibodies; Tonsil; complement receptor 2; Epithelium; Antigen processing; Immune response; Human immunodeficiency virus DO - http://dx.doi.org/10.2353/ajpath.2007.061006 ER - TY - JOUR T1 - NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of hydroxyurea AN - 21056489; 7596918 AB - Abstract not available. JF - Birth Defects Research Part B: Developmental and Reproductive Toxicology AU - Liebelt, Erica L AU - Balk, Sophie J AU - Faber, Willem AU - Fisher, Jeffrey W AU - Hughes, Claude L AU - Lanzkron, Sophie M AU - Lewis, Kerry M AU - Marchetti, Francesco AU - Mehendale, Harihara M AU - Rogers, John M AU - Shad, Aziza T AU - Skalko, Richard G AU - Stanek, Edward J AD - University of Alabama, Birmingham, AL, Shelby@niehs.nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 259 EP - 366 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 80 IS - 4 SN - 1542-9733, 1542-9733 KW - Toxicology Abstracts KW - Hydroxyurea KW - Congenital defects KW - Toxicity KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21056489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.atitle=NTP-CERHR+Expert+Panel+Report+on+the+reproductive+and+developmental+toxicity+of+hydroxyurea&rft.au=Liebelt%2C+Erica+L%3BBalk%2C+Sophie+J%3BFaber%2C+Willem%3BFisher%2C+Jeffrey+W%3BHughes%2C+Claude+L%3BLanzkron%2C+Sophie+M%3BLewis%2C+Kerry+M%3BMarchetti%2C+Francesco%3BMehendale%2C+Harihara+M%3BRogers%2C+John+M%3BShad%2C+Aziza+T%3BSkalko%2C+Richard+G%3BStanek%2C+Edward+J&rft.aulast=Liebelt&rft.aufirst=Erica&rft.date=2007-08-01&rft.volume=80&rft.issue=4&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.issn=15429733&rft_id=info:doi/10.1002%2Fbdrc.20068 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Hydroxyurea; Congenital defects; Toxicity DO - http://dx.doi.org/10.1002/bdrc.20068 ER - TY - JOUR T1 - Purine Salvage Pathways among Borrelia Species AN - 21006252; 7530478 AB - Genome sequencing projects on two relapsing fever spirochetes, Borrelia hermsii and Borrelia turicatae, revealed differences in genes involved in purine metabolism and salvage compared to those in the Lyme disease spirochete Borrelia burgdorferi. The relapsing fever spirochetes contained six open reading frames that are absent from the B. burgdorferi genome. These genes included those for hypoxanthine-guanine phosphoribosyltransferase (hpt), adenylosuccinate synthase (purA), adenylosuccinate lyase (purB), auxiliary protein (nrdI), the ribonucleotide-diphosphate reductase alpha subunit (nrdE), and the ribonucleotide-diphosphate reductase beta subunit (nrdF). Southern blot assays with multiple Borrelia species and isolates confirmed the presence of these genes in the relapsing fever group of spirochetes but not in B. burgdorferi and related species. TaqMan real-time reverse transcription-PCR demonstrated that the chromosomal genes (hpt, purA, and purB) were transcribed in vitro and in mice. Phosphoribosyltransferase assays revealed that, in general, B. hermsii exhibited significantly higher activity than did the B. burgdorferi cell lysate, and enzymatic activity was observed with adenine, hypoxanthine, and guanine as substrates. B. burgdorferi showed low but detectable phosphoribosyltransferase activity with hypoxanthine even though the genome lacks a discernible ortholog to the hpt gene in the relapsing fever spirochetes. B. hermsii incorporated radiolabeled hypoxanthine into RNA and DNA to a much greater extent than did B. burgdorferi. This complete pathway for purine salvage in the relapsing fever spirochetes may contribute, in part, to these spirochetes achieving high cell densities in blood. JF - Infection and Immunity AU - Pettersson, Jonas AU - Schrumpf, Merry E AU - Raffel, Sandra J AU - Porcella, Stephen F AU - Guyard, Cyril AU - Lawrence, Kevin AU - Gherardini, Frank C AU - Schwan, Tom G AD - Laboratory of Zoonotic Pathogens. Research Technologies Section, Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840 Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 3877 EP - 3884 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 8 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Genomes KW - Borrelia hermsii KW - HPT gene KW - Relapsing fever KW - Cell density KW - phosphoribosyltransferase KW - Guanine KW - reductase KW - Adenine KW - Enzymatic activity KW - Lyme disease KW - Adenylosuccinate lyase KW - Borrelia burgdorferi KW - Lymphocytes B KW - Borrelia turicatae KW - purines KW - Spirochetes KW - Blood KW - RNA KW - Adenylosuccinate synthase KW - Hypoxanthine KW - DNA KW - Open reading frames KW - Metabolism KW - J 02320:Cell Biology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21006252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Purine+Salvage+Pathways+among+Borrelia+Species&rft.au=Pettersson%2C+Jonas%3BSchrumpf%2C+Merry+E%3BRaffel%2C+Sandra+J%3BPorcella%2C+Stephen+F%3BGuyard%2C+Cyril%3BLawrence%2C+Kevin%3BGherardini%2C+Frank+C%3BSchwan%2C+Tom+G&rft.aulast=Pettersson&rft.aufirst=Jonas&rft.date=2007-08-01&rft.volume=75&rft.issue=8&rft.spage=3877&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; Adenylosuccinate lyase; HPT gene; Lymphocytes B; Relapsing fever; phosphoribosyltransferase; Cell density; purines; Blood; Spirochetes; Guanine; reductase; RNA; Adenylosuccinate synthase; DNA; Hypoxanthine; Adenine; Enzymatic activity; Metabolism; Open reading frames; Lyme disease; Borrelia hermsii; Borrelia burgdorferi; Borrelia turicatae ER - TY - JOUR T1 - CYP3A4 and pregnane X receptor humanized mice AN - 21004407; 8499574 AB - Marked species differences exist in P450 expression and activities. In order to produce mouse models that can be used to more accurately predict human drug and carcinogen metabolism, P450- and xenobiotic receptor humanized mice are being prepared using bacterial artificial chromosomes (BAC) and P1 phage artificial chromosomes (PAC) genomic clones. In some cases, transgenic mice carrying the human genes are bred with null-mice to produce fully humanized mice. Mice expressing human CYP1A1, CYP1A2, CYP2E1, CYP2D6, CYP3A4, and CYP3A7 were generated and characterized. Studies with the CYP3A4-humanized (hCYP3A4) mouse line revealed new information on the physiological function of this P450 and its role in drug metabolism in vivo. With this mouse line, CYP3A4, under certain circumstances, was found to alter the serum levels of estrogen resulting in deficient lactation and low pup survival as a result of underdeveloped mammary glands. This hCYP3A4 mouse established the importance of intestinal CYP3A4 in the pharmacokinetics of orally administered drugs. The hCYP3A4 mice were also used to establish the mechanisms of potential gender differences in CYP3A4 expression (adult female > adult male) that could account for human gender differences in drug metabolism and response. The pregnane X receptor (PXR) is also involved in induction of drug metabolism through its target genes including CYP3A4. Since species differences exist in ligand specificity between human and mice, a PXR-humanized mouse (hPXR) was produced that responds to human PXR activators such as rifampicin but does not respond to the rodent activator pregnenalone 16-carbonitrile. JF - Journal of Biochemical and Molecular Toxicology AU - Gonzalez, Frank J AD - Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, fjgonz@helix.nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 158 EP - 162 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 21 IS - 4 SN - 1095-6670, 1095-6670 KW - Microbiology Abstracts B: Bacteriology KW - Phages KW - Animal models KW - Survival KW - Carcinogens KW - Sex differences KW - Rifampin KW - Chromosomes KW - genomics KW - Drugs KW - Estrogens KW - CYP1A2 protein KW - CYP3A7 protein KW - Mammary gland KW - Drug metabolism KW - Oral administration KW - Transgenic mice KW - Pharmacokinetics KW - Lactation KW - Bacterial artificial chromosomes KW - Serum levels KW - Intestine KW - pregnane X receptors KW - Cytochrome P450 KW - CYP2D6 protein KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21004407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biochemical+and+Molecular+Toxicology&rft.atitle=CYP3A4+and+pregnane+X+receptor+humanized+mice&rft.au=Gonzalez%2C+Frank+J&rft.aulast=Gonzalez&rft.aufirst=Frank&rft.date=2007-08-01&rft.volume=21&rft.issue=4&rft.spage=158&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biochemical+and+Molecular+Toxicology&rft.issn=10956670&rft_id=info:doi/10.1002%2Fjbt.20173 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Phages; Estrogens; CYP1A2 protein; CYP3A7 protein; Mammary gland; Drug metabolism; Oral administration; Animal models; Survival; Carcinogens; Transgenic mice; Sex differences; Pharmacokinetics; Lactation; Serum levels; Bacterial artificial chromosomes; Rifampin; Chromosomes; Intestine; genomics; Cytochrome P450; pregnane X receptors; Drugs; CYP2D6 protein DO - http://dx.doi.org/10.1002/jbt.20173 ER - TY - JOUR T1 - Amended Description of the Genes for Synthesis of Actinomyces naeslundii T14V Type 1 Fimbriae and Associated Adhesin AN - 21000889; 7530510 AB - The type 1 fimbriae of Actinomyces naeslundii T14V mediate adhesion of this gram-positive species to the tooth surface. The present findings show that the locus for type 1 fimbria production in this strain includes three genes, fimQ for a minor fimbrial subunit that appears to be an adhesin, fimP for the major structural subunit, and srtC1 for a type 1 fimbria-specific sortase involved in the assembly of these structures. JF - Infection and Immunity AU - Chen, Ping AU - Cisar, John O AU - Hess, Sonja AU - Ho, Jenny TC AU - Leung, Kai P AD - Microbiology Branch, U.S. Army Dental and Trauma Research Detachment, Walter Reed Army Institute of Research, Great Lakes, Illinois 60088. Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research. Proteomics and Mass Spectrometry Facility, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 4181 EP - 4185 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 8 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Teeth KW - Adhesins KW - Pili KW - sortase KW - Actinomyces naeslundii KW - Fimbria KW - J 02310:Genetics & Taxonomy KW - F 06910:Microorganisms & Parasites KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21000889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Amended+Description+of+the+Genes+for+Synthesis+of+Actinomyces+naeslundii+T14V+Type+1+Fimbriae+and+Associated+Adhesin&rft.au=Chen%2C+Ping%3BCisar%2C+John+O%3BHess%2C+Sonja%3BHo%2C+Jenny+TC%3BLeung%2C+Kai+P&rft.aulast=Chen&rft.aufirst=Ping&rft.date=2007-08-01&rft.volume=75&rft.issue=8&rft.spage=4181&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Teeth; Adhesins; Pili; sortase; Actinomyces naeslundii; Fimbria ER - TY - JOUR T1 - Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8 super(+) T cells via TLR4 signaling AN - 20953660; 11055115 AB - Lymphodepletion with total body irradiation (TBI) increases the efficacy of adoptively transferred tumor-specific CD8 super(+) T cells by depleting inhibitory lymphocytes and increasing homeostatic cytokine levels. We found that TBI augmented the function of adoptively transferred CD8 super(+) T cells in mice genetically deficient in all lymphocytes, indicating the existence of another TBI mechanism of action. Additional investigation revealed commensal gut microflora in the mesenteric lymph nodes and elevated LPS levels in the sera of irradiated mice. These findings correlated with increased dendritic cell activation and heightened levels of systemic inflammatory cytokines. Reduction of host microflora using antibiotics, neutralization of serum LPS using polymyxin B, or removal of LPS signaling components using mice genetically deficient in CD14 and TLR4 reduced the beneficial effects of TBI on tumor regression. Conversely, administration of microbial ligand-containing serum or ultrapure LPS from irradiated animals to nonirradiated antibody-lymphodepleted mice enhanced CD8 super(+) T cell activation and improved tumor regression. Administration of ultrapure LPS to irradiated animals further enhanced the number and function of the adoptively transferred cells, leading to long-term cure of mice with large B16F10 tumors and enhanced autoimmune vitiligo. Thus, disruption of the homeostatic balance between the host and microbes can enhance cell-based tumor immunotherapy. JF - Journal of Clinical Investigation AU - Paulos, G M AU - Wrzesinski, C AU - Kaiser, A AU - Hinrichs, C S AU - Chieppa, M AU - Cassard, L AU - Palmer, D C AU - Boni, A AU - Muranski, P AU - Yu, Z AU - Gattinoni, L AU - Antony, P A AU - Rosenberg, SA AU - Restifo, N P AD - National Cancer Institute (NCI), NIH, Bethesda, Maryland, USA Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 2197 EP - 2204 VL - 117 IS - 8 SN - 0021-9738, 0021-9738 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Immunotherapy KW - Commensals KW - Antibiotics KW - polymyxin B KW - CD8 antigen KW - Tumors KW - CD14 antigen KW - Vitiligo KW - Lymph nodes KW - Cell activation KW - Inflammation KW - Dendritic cells KW - Digestive tract KW - Radiation KW - Microflora KW - Lymphocytes T KW - Cytokines KW - Lipopolysaccharides KW - TLR4 protein KW - Translocation KW - Toll-like receptors KW - Signal transduction KW - A 01340:Antibiotics & Antimicrobials KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20953660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Investigation&rft.atitle=Microbial+translocation+augments+the+function+of+adoptively+transferred+self%2Ftumor-specific+CD8+super%28%2B%29+T+cells+via+TLR4+signaling&rft.au=Paulos%2C+G+M%3BWrzesinski%2C+C%3BKaiser%2C+A%3BHinrichs%2C+C+S%3BChieppa%2C+M%3BCassard%2C+L%3BPalmer%2C+D+C%3BBoni%2C+A%3BMuranski%2C+P%3BYu%2C+Z%3BGattinoni%2C+L%3BAntony%2C+P+A%3BRosenberg%2C+SA%3BRestifo%2C+N+P&rft.aulast=Paulos&rft.aufirst=G&rft.date=2007-08-01&rft.volume=117&rft.issue=8&rft.spage=2197&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Investigation&rft.issn=00219738&rft_id=info:doi/10.1172%2FJCI32205 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Immunotherapy; Commensals; Antibiotics; Tumors; CD8 antigen; polymyxin B; CD14 antigen; Vitiligo; Lymph nodes; Inflammation; Cell activation; Dendritic cells; Digestive tract; Radiation; Lymphocytes T; Microflora; Lipopolysaccharides; Cytokines; Translocation; TLR4 protein; Toll-like receptors; Signal transduction DO - http://dx.doi.org/10.1172/JCI32205 ER - TY - JOUR T1 - Three-dimensional analytical magnetic resonance imaging phantom in the Fourier domain AN - 20858045; 8368550 AB - This work presents a basic framework for constructing a 3D analytical MRI phantom in the Fourier domain. In the image domain the phantom is modeled after the work of Kak and Roberts on a 3D version of the famous Shepp-Logan head phantom. This phantom consists of several ellipsoids of different sizes, orientations, locations, and signal intensities (or gray levels). It will be shown that the k-space signal derived from the phantom can be analytically expressed. As a consequence, it enables one to bypass the need for interpolation in the Fourier domain when testing image-reconstruction algorithms. More importantly, the proposed framework can serve as a benchmark for contrasting and comparing different image-reconstruction techniques in 3D MRI with a non-Cartesian k-space trajectory. The proposed framework can also be adapted for 3D MRI simulation studies in which the MRI parameters of interest may be introduced to the signal intensity from the ellipsoid. JF - Magnetic Resonance in Medicine AU - Koay, Cheng Guan AU - Sarlls, Joelle E AU - Ozarslan, Evren AD - National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA, guankoac@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 430 EP - 436 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 58 IS - 2 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Head KW - Magnetic resonance imaging KW - Algorithms KW - N.M.R. KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20858045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Three-dimensional+analytical+magnetic+resonance+imaging+phantom+in+the+Fourier+domain&rft.au=Koay%2C+Cheng+Guan%3BSarlls%2C+Joelle+E%3BOzarslan%2C+Evren&rft.aulast=Koay&rft.aufirst=Cheng&rft.date=2007-08-01&rft.volume=58&rft.issue=2&rft.spage=430&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21292 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; Algorithms; Head; N.M.R. DO - http://dx.doi.org/10.1002/mrm.21292 ER - TY - JOUR T1 - Single-walled tubulin ring polymers AN - 20798845; 7586148 AB - An unusual class of nanoscopic, ring-shaped, single-walled biopolymers arises when -tubulin is mixed with certain small peptides obtained from various marine organisms and cyanobacteria. The single-ring structures, whose mean molecular weight depends on the specific peptide added to the reaction mixture, usually have sharp mass distributions corresponding, e.g., to rings containing eight tubulin dimers (when the added peptide is cryptophycin) and 14 dimers (e.g., with dolastatin). Although the ring-forming peptides have been shown to possess antimitotic properties when tested with cultured eukaryotic cells (and thus have generated considerable interest as possible agents to be used in the treatment of cancer), it is not our intention to extensively discuss the potential pharmacological properties of the peptides. Rather, we will review the polymeric structures that form and illustrate how certain physical techniques can be used to characterize their properties and interactions. The nanoscopic size and particular geometry of the individual rings make them appropriate targets for scattering and hydrodynamic techniques that provide details about their structure in solution, but it is necessary to relate measured data to postulated structures by nontrivial, albeit straight-forward, mathematical, and computational means. We will discuss how this is done when one uses such methods as small angle neutron scattering, dynamic light scattering, fluorescence correlation spectroscopy, and sedimentation velocity measurements. Moreover, we show that, by using several techniques, one can eliminate degeneracy to provide better discrimination between model structures. JF - Biopolymers AU - Boukari, Hacene AU - Sackett, Dan L AU - Schuck, Peter AU - Nossal, Ralph J AD - Laboratory of Integrative and Medical Biophysics, NICHD, National Institutes of Health, Bethesda, MD 20892, boukarih@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 424 EP - 436 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 86 IS - 5-6 SN - 0006-3525, 0006-3525 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - Mathematical models KW - Hydrodynamics KW - Motivation KW - Light scattering KW - Biopolymers KW - Computer applications KW - Cancer KW - fluorescence spectroscopy KW - Neutron scattering KW - Reviews KW - Molecular weight KW - Marine organisms KW - Sedimentation KW - Tubulin KW - K 03330:Biochemistry KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20798845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biopolymers&rft.atitle=Single-walled+tubulin+ring+polymers&rft.au=Boukari%2C+Hacene%3BSackett%2C+Dan+L%3BSchuck%2C+Peter%3BNossal%2C+Ralph+J&rft.aulast=Boukari&rft.aufirst=Hacene&rft.date=2007-08-01&rft.volume=86&rft.issue=5-6&rft.spage=424&rft.isbn=&rft.btitle=&rft.title=Biopolymers&rft.issn=00063525&rft_id=info:doi/10.1002%2Fbip.20752 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Mathematical models; Motivation; Hydrodynamics; Biopolymers; Light scattering; Computer applications; Cancer; fluorescence spectroscopy; Neutron scattering; Molecular weight; Reviews; Marine organisms; Tubulin; Sedimentation DO - http://dx.doi.org/10.1002/bip.20752 ER - TY - JOUR T1 - A prospective study of polymorphisms of DNA repair genes XRCC1, XPD23 and APE/ref-1 and risk of stroke in Linxian, China AN - 20756886; 7531528 AB - BACKGROUND: Stroke is the leading cause of death in Linxian, China. Although there is evidence of DNA damage in experimental stroke, no data exist on DNA repair and stroke in human populations. Aim: To assess the risk of stroke conferred by polymorphisms in the DNA repair genes, XRCC1, XPD23 and APE/ref-1 in a cohort of individuals originally assembled as subjects in two cancer prevention trials in Linxian, China. METHODS: The subjects for this prospective study were sampled from a cohort of 4005 eligible subjects who were alive and cancer free in 1991 and had blood samples available for DNA extraction. Using real-time Taqman analyses, all incident cases of stroke (n = 118) that developed from May 1996, and an age- and a sex-stratified random sample (n = 454) drawn from all eligible subjects were genotyped. Cox proportional hazards models were used to estimate relative risks (RRs) and 95% CIs. RESULTS: No association was observed between polymorphisms in APE/ref-1 codon 148 and XRCC1*6 codon 194, and stroke. Polymorphisms in XRCC1*10 codon 399 were associated with a significantly reduced risk of stroke (RR 0.59, 95% CI 0.36 to 0.96, p = 0.033), whereas XPD23 codon 312 was associated with a significantly increased risk of stroke (RR 2.18, 95% CI 1.14 to 4.17, p = 0.010). CONCLUSIONS: Polymorphisms in DNA repair genes may be important in the aetiology of stroke. These data should stimulate research on DNA damage and repair in stroke. JF - Journal of Epidemiology and Community Health AU - Mahabir, Somdat AU - Abnet, Christian C AU - Qiao, You-Lin AU - Ratnasinghe, Luke D AU - Dawsey, Sanford M AU - Dong, Zhi-Wei AU - Taylor, Philip R AU - Mark, Steven D AD - Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. Department of Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing, People's Republic of China. Center for Structural Genomics, NCTR, Food and Drug Administration, Jefferson and Arkansas Cancer Research Center, UAMS, Little Rock, Arkansas, USA. Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 737 EP - 741 PB - British Medical Association, BMA House Square Tavistock Square London WC1H 9JP UK, [mailto:info.web@bma.org.uk], [URL:http://www.bma.org.uk/] VL - 61 IS - 8 SN - 0143-005X, 0143-005X KW - stroke KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Risk Abstracts KW - Risk assessment KW - Mortality KW - Gene polymorphism KW - Stroke KW - X chromosome KW - XRCC1 protein KW - DNA repair KW - Cancer KW - Models KW - risk reduction KW - DNA damage KW - DNA KW - prevention KW - Codons KW - China, People's Rep. KW - human populations KW - G 07880:Human Genetics KW - N 14820:DNA Metabolism & Structure KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20756886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Epidemiology+and+Community+Health&rft.atitle=A+prospective+study+of+polymorphisms+of+DNA+repair+genes+XRCC1%2C+XPD23+and+APE%2Fref-1+and+risk+of+stroke+in+Linxian%2C+China&rft.au=Mahabir%2C+Somdat%3BAbnet%2C+Christian+C%3BQiao%2C+You-Lin%3BRatnasinghe%2C+Luke+D%3BDawsey%2C+Sanford+M%3BDong%2C+Zhi-Wei%3BTaylor%2C+Philip+R%3BMark%2C+Steven+D&rft.aulast=Mahabir&rft.aufirst=Somdat&rft.date=2007-08-01&rft.volume=61&rft.issue=8&rft.spage=737&rft.isbn=&rft.btitle=&rft.title=Journal+of+Epidemiology+and+Community+Health&rft.issn=0143005X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; DNA damage; Gene polymorphism; X chromosome; Stroke; Codons; XRCC1 protein; DNA repair; Cancer; Models; Mortality; risk reduction; prevention; DNA; human populations; China, People's Rep. ER - TY - JOUR T1 - Effect of Human Papillomavirus 16/18 L1 Viruslike Particle Vaccine Among Young Women With Preexisting Infection: A Randomized Trial AN - 20723533; 7557288 AB - CONTEXT: Viruslike particle human papillomavirus (HPV) vaccines were designed to prevent HPV infection and development of cervical precancers and cancer. Women with oncogenic HPV infections might consider vaccination as therapy. OBJECTIVE: To determine whether vaccination against HPV types 16 and 18 increases the rate of viral clearance in women already infected with HPV. DESIGN AND SETTING: Phase 3, masked, community-based randomized trial conducted in 2 provinces of Costa Rica. PARTICIPANTS: A total of 2189 women aged 18 to 25 years who were recruited between June 2004 and December 2005. Participants were positive for HPV DNA at enrollment, had at least 6 months of follow-up, and had follow-up HPV DNA results. INTERVENTION: Participants were randomly assigned to receive 3 doses of a bivalent HPV-16/18 L1 protein viruslike particle AS04 candidate vaccine (n = 1088) or a control hepatitis A vaccine (n = 1101) over 6 months. MAIN OUTCOME MEASURES: Presence of HPV DNA was determined in cervical specimins by a molecular hybridization assay using chemiluminescence with HPV RNA probes and by polymerase chain reaction using SPF10 primers and a line probe assay detection system before vaccination and by polymerase chain reaction after vaccination. We compared rates of type-specific viral clearance using generalized estimating equations methods at the 6-month visit (after 2 doses) and 12-month visit (after 3 doses) in the 2 study groups. RESULTS: There was no evidence of increased viral clearance at 6 or 12 months in the group who received HPV vaccine compared with the control group. Clearance rates for HPV-16/18 infections at 6 months were 33.4% (82/248) in the HPV vaccine group and 31.6% (95/298) in the control group (vaccine efficacy for viral clearance, 2.5%; 95% confidence interval, -9.8% to 13.5%). Human papillomavirus 16/18 clearance rates at 12 months were 48.8% (86/177) in the HPV vaccine group and 49.8% (110/220) in the control group (vaccine efficacy for viral clearance, -2.0%; 95% confidence interval, -24.3% to 16.3%). There was no evidence of a therapeutic effect for other oncogenic or nononcogenic HPV categories, among women receiving all vaccine doses, among women with single infections, or among women stratified by the following entry variables: HPV-16/18 serology, cytologic results, HPV DNA viral load, time since sexual debut, Chlamydia trachomatis or Neisseria gonorrhoeae infection, hormonal contraceptive use, or smoking. CONCLUSION: In women positive for HPV DNA, HPV-16/18 vaccination does not accelerate clearance of the virus and should not be used to treat prevalent infections. Trial Registration clinicaltrials.gov Identifier: NCT00128661 JF - JAMA: Journal of the American Medical Association AU - Hildesheim, Allan AU - Herrero, Rolando AU - Wacholder, Sholom AU - Rodriguez, Ana C AU - Solomon, Diane AU - Bratti, MConcepcion AU - Schiller, John T AU - Gonzalez, Paula AU - Dubin, Gary AU - Porras, Carolina AU - Jimenez, Silvia E AU - Lowy, Douglas R AD - Division of Cancer Epidemiology and Genetics (Drs Hildesheim and Wacholder), Division of Cancer Prevention and Control (Dr Solomon), and Center for Cancer Research (Drs Schiller and Lowy), National Cancer Institute, Bethesda, Maryland Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 743 EP - 753 PB - American Medical Association, 515 N. State St. Chicago IL 60610 USA VL - 298 IS - 7 SN - 0098-7484, 0098-7484 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Mathematical models KW - DNA probes KW - Chlamydia trachomatis KW - Infection KW - Serology KW - Vaccination KW - Neisseria gonorrhoeae KW - Cancer KW - double prime L1 protein KW - Smoking KW - RNA probes KW - Human papillomavirus 16 KW - Hepatitis A KW - Polymerase chain reaction KW - Primers KW - Vaccines KW - Chemiluminescence KW - Cervix KW - Contraceptives KW - J 02350:Immunology KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20723533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA%3A+Journal+of+the+American+Medical+Association&rft.atitle=Effect+of+Human+Papillomavirus+16%2F18+L1+Viruslike+Particle+Vaccine+Among+Young+Women+With+Preexisting+Infection%3A+A+Randomized+Trial&rft.au=Hildesheim%2C+Allan%3BHerrero%2C+Rolando%3BWacholder%2C+Sholom%3BRodriguez%2C+Ana+C%3BSolomon%2C+Diane%3BBratti%2C+MConcepcion%3BSchiller%2C+John+T%3BGonzalez%2C+Paula%3BDubin%2C+Gary%3BPorras%2C+Carolina%3BJimenez%2C+Silvia+E%3BLowy%2C+Douglas+R&rft.aulast=Hildesheim&rft.aufirst=Allan&rft.date=2007-08-01&rft.volume=298&rft.issue=7&rft.spage=743&rft.isbn=&rft.btitle=&rft.title=JAMA%3A+Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Mathematical models; DNA probes; Infection; Vaccination; Serology; Cancer; double prime L1 protein; Smoking; RNA probes; Polymerase chain reaction; Hepatitis A; Primers; Vaccines; Cervix; Chemiluminescence; Contraceptives; Human papillomavirus 16; Chlamydia trachomatis; Neisseria gonorrhoeae ER - TY - JOUR T1 - Polymorphisms in Apoptosis and Cell Cycle Control Genes and Risk of Brain Tumors in Adults AN - 20720908; 7555870 AB - Despite the potential importance of the cell cycle and apoptosis pathways in brain tumor etiology, little has been published regarding brain tumor risk associated with common gene variants in these pathways. Using data from a hospital-based case-control study conducted by the National Cancer Institute between 1994 and 1998, we evaluated risk of glioma (n = 388), meningioma (n = 162), and acoustic neuroma (n = 73) with respect to 12 single nucleotide polymorphisms from 10 genes involved in apoptosis and cell cycle control: CASP8, CCND1, CCNH, CDKN1A, CDKN2A, CHEK1, CHEK2, MDM2, PTEN, and TP53. We observed significantly decreased risk of meningioma with the CASP8 Ex14-271A>T variant [odds ratio (OR) sub(AT), 0.8; 95% confidence interval (95% CI), 0.5-1.2; OR sub(AA), 0.5; 95% CI, 0.3-0.9; P sub(trend) = 0.03] and increased risk of meningioma with the CASP8 Ex13+51G>C variant (OR sub(GC), 1.4; 95% CI, 0.9-2.1; OR sub(CC), 3.6; 95% CI, 1.0-13.1; P sub(trend) = 0.04). The CT haplotype of the two CASP8 polymorphisms was associated with significantly increased risk of meningioma (OR, 1.7; 95% CI, 1.1-2.6), but was not associated with risk of glioma or acoustic neuroma. The CCND1 Ex4-1G>A variant was associated with increased risk for glioma, and the Ex8+49T>C variant of CCNH was associated with increased risk of glioma and acoustic neuroma. The MDM2 Ex12+162A>G variant was associated with significantly reduced risk of glioma. Our results suggest that common variants in the CASP8, CCND1, CCNH, and MDM2 genes may influence brain tumor risk. Future research in this area should include more detailed coverage of genes in the apoptosis/cell cycle control pathways. (Cancer Epidemiol Biomarkers Prev 2007; 16(8):1655-61) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Rajaraman, Preetha AU - Wang, Sophia S AU - Rothman, Nathaniel AU - Brown, Merideth M AU - Black, Peter M AU - Fine, Howard A AU - Loeffler, Jay S AU - Selker, Robert G AU - Shapiro, William R AU - Chanock, Stephen J AU - Inskip, Peter D AD - Division of Cancer Epidemiology and Genetics, Core Genotyping Facility, Neuro-oncology Branch, and Pediatric Oncology Branch, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 1655 EP - 1661 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 8 SN - 1055-9965, 1055-9965 KW - Genetics Abstracts; Risk Abstracts; CSA Neurosciences Abstracts KW - Apoptosis KW - Gene polymorphism KW - Cell cycle KW - PTEN protein KW - Neoplasia KW - glioma KW - risk reduction KW - Haplotypes KW - prevention KW - Glioma KW - brain tumors KW - Bioindicators KW - MDM2 protein KW - Etiology KW - Data processing KW - haplotypes KW - biomarkers KW - Cancer KW - p53 protein KW - Brain tumors KW - Single-nucleotide polymorphism KW - France, Aquitaine, Oraas KW - meningioma KW - N3 11023:Neurogenetics KW - R2 23060:Medical and environmental health KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20720908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Polymorphisms+in+Apoptosis+and+Cell+Cycle+Control+Genes+and+Risk+of+Brain+Tumors+in+Adults&rft.au=Rajaraman%2C+Preetha%3BWang%2C+Sophia+S%3BRothman%2C+Nathaniel%3BBrown%2C+Merideth+M%3BBlack%2C+Peter+M%3BFine%2C+Howard+A%3BLoeffler%2C+Jay+S%3BSelker%2C+Robert+G%3BShapiro%2C+William+R%3BChanock%2C+Stephen+J%3BInskip%2C+Peter+D&rft.aulast=Rajaraman&rft.aufirst=Preetha&rft.date=2007-08-01&rft.volume=16&rft.issue=8&rft.spage=1655&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - MDM2 protein; Etiology; Data processing; Apoptosis; Gene polymorphism; Cell cycle; PTEN protein; biomarkers; Neoplasia; p53 protein; Brain tumors; Haplotypes; Single-nucleotide polymorphism; Glioma; meningioma; Bioindicators; risk reduction; glioma; prevention; haplotypes; brain tumors; Cancer; France, Aquitaine, Oraas ER - TY - JOUR T1 - Transduction of Rhesus Macaque Hematopoietic Stem and Progenitor Cells with Avian Sarcoma and Leukosis Viral Vectors AN - 20704325; 7588538 AB - Genome-wide integration site analyses showed that Moloney murine leukemia virus (MoMLV)- and lentivirus-derived vectors integrate preferentially into the coding regions of genes, posing a risk of insertional mutagenesis. Avian sarcoma and leukosis viruses (ASLVs) were previously reported to have a weak preference for gene-coding regions in a cell line study as compared with human immunodeficiency virus and MoMLV; however, thus far these vectors have not been studied for their potential efficacy in transduction of hematopoietic progenitor and stem cells. In this study we investigated for the first time the ability of ASLV-derived RCAS (replication-competent ALV LTR [avian leukosis virus long terminal repeat] with a splice acceptor) vectors to transduce rhesus macaque hematopoietic progenitors and long-term repopulating cells, in an autologous transplantation model. RCAS vectors can efficiently and stably transduce rhesus macaque CD34+ hematopoietic progenitor cells with an efficiency of transduction of up to 34% ex vivo. In two animals transplanted with RCAS vector-transduced autologous CD34 super(+) cells, highly polyclonal hematopoietic reconstitution with sustained gene-marking levels in myeloid and lymphoid lineages was observed up to 18 months post-transplantation. These findings are encouraging and suggest that this vector system should be explored and further optimized for gene therapy applications targeting hematopoietic stem and progenitor cells. JF - Human Gene Therapy AU - Hu, J AU - Ferris, A AU - Larochelle, A AU - Krouse, A E AU - Metzger, ME AU - Donahue, R E AU - Hughes, SH AU - Dunbar, CE AD - Molecular Hematopoiesis Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1202, dunbarc@nhlbi.nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 691 EP - 700 VL - 18 IS - 8 SN - 1043-0342, 1043-0342 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Autografts KW - Moloney murine leukemia virus KW - Gene therapy KW - Long terminal repeat KW - Animal models KW - Avian leukosis KW - CD34 antigen KW - Expression vectors KW - Integration KW - Avian leukosis virus KW - Stem cells KW - Leukosis KW - Human immunodeficiency virus KW - insertional mutagenesis KW - Sarcoma KW - Hemopoiesis KW - Macaca mulatta KW - Avian sarcoma and leukosis virus KW - W 30905:Medical Applications KW - V 22360:AIDS and HIV KW - F 06950:Immunogenetics, MHC, HLA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20704325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Transduction+of+Rhesus+Macaque+Hematopoietic+Stem+and+Progenitor+Cells+with+Avian+Sarcoma+and+Leukosis+Viral+Vectors&rft.au=Hu%2C+J%3BFerris%2C+A%3BLarochelle%2C+A%3BKrouse%2C+A+E%3BMetzger%2C+ME%3BDonahue%2C+R+E%3BHughes%2C+SH%3BDunbar%2C+CE&rft.aulast=Hu&rft.aufirst=J&rft.date=2007-08-01&rft.volume=18&rft.issue=8&rft.spage=691&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2006.175 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Autografts; Gene therapy; Long terminal repeat; Animal models; CD34 antigen; Avian leukosis; Expression vectors; Integration; Stem cells; Leukosis; insertional mutagenesis; Sarcoma; Hemopoiesis; Avian leukosis virus; Moloney murine leukemia virus; Human immunodeficiency virus; Macaca mulatta; Avian sarcoma and leukosis virus DO - http://dx.doi.org/10.1089/hum.2006.175 ER - TY - JOUR T1 - Cutaneous phenotype and MC1R variants as modifying factors for the development of melanoma in CDKN2A G101W mutation carriers from 4 countries AN - 20650251; 8079549 AB - The G101W founder mutation is the most common CDKN2A mutation in Italy, Spain, and France. As the background of modifying genes, environmental exposures, and sun behavior vary across countries, studying G101W carriers from distinct countries offers a unique opportunity to evaluate possible modifying factors in melanoma development. We evaluated 76 G101W cases and 59 carrier controls from France, Italy, Spain, and the United States. Hair color and dysplastic nevi distributions differed significantly in cases and controls across the 4 study groups. Cases also varied significantly for eye color, freckling, and nevi. The distribution of MC1R variants in cases differed significantly across study groups because 12% of Italian melanoma patients had 2 MC1R variants vs. >50% for the other case groups. Several MC1R covariates showed significant associations with melanoma risk in all groups combined and in the American, French, and Spanish samples; no significant findings were observed in the Italian sample. In multiple-case families, the number and type of MC1R variants varied significantly between multiple-primary-melanoma and single-primary-melanoma patients from the 4 groups; there was also a significant decrease in median age at melanoma diagnosis as the number or type of MC1R variants increased. The variation in the effects of the cutaneous phenotypic and MC1R factors across the study sample suggests that these factors differentially contribute to development of melanoma even on a common genetic background of a germline CDKN2A mutation. Differences in melanoma risk across geographic regions justify the need for individual studies in each country before counseling should be considered. JF - International Journal of Cancer AU - Goldstein, Alisa M AU - Chaudru, Valerie AU - Ghiorzo, Paola AU - Badenas, Celia AU - Malvehy, Josep AU - Pastorino, Lorenza AU - Laud, Karine AU - Hulley, Benjamin AU - Avril, Marie-Francoise AU - Puig-Butille, Joan A AU - Miniere, Annie AU - Marti, Rosa AU - Chompret, Agnes AU - Cuellar, Francisco AU - Kolm, Isabel AU - Mila, Montserrat AU - Tucker, Margaret A AU - Demenais, Florence AU - Bianchi-Scarra, Giovanna AU - Puig, Susana AU - de-Paillerets, Brigitte Bressac AD - Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, goldstea@exchange.nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 825 EP - 831 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 121 IS - 4 SN - 0020-7136, 0020-7136 KW - Genetics Abstracts; Risk Abstracts KW - Age KW - Eye KW - Spain KW - melanoma KW - Hair KW - Italy KW - Cancer KW - Melanoma KW - Color KW - France KW - USA KW - Sun KW - Mutation KW - R2 23060:Medical and environmental health KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20650251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Cutaneous+phenotype+and+MC1R+variants+as+modifying+factors+for+the+development+of+melanoma+in+CDKN2A+G101W+mutation+carriers+from+4+countries&rft.au=Goldstein%2C+Alisa+M%3BChaudru%2C+Valerie%3BGhiorzo%2C+Paola%3BBadenas%2C+Celia%3BMalvehy%2C+Josep%3BPastorino%2C+Lorenza%3BLaud%2C+Karine%3BHulley%2C+Benjamin%3BAvril%2C+Marie-Francoise%3BPuig-Butille%2C+Joan+A%3BMiniere%2C+Annie%3BMarti%2C+Rosa%3BChompret%2C+Agnes%3BCuellar%2C+Francisco%3BKolm%2C+Isabel%3BMila%2C+Montserrat%3BTucker%2C+Margaret+A%3BDemenais%2C+Florence%3BBianchi-Scarra%2C+Giovanna%3BPuig%2C+Susana%3Bde-Paillerets%2C+Brigitte+Bressac&rft.aulast=Goldstein&rft.aufirst=Alisa&rft.date=2007-08-01&rft.volume=121&rft.issue=4&rft.spage=825&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22712 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Age; Eye; Sun; Hair; Mutation; Color; Melanoma; melanoma; Cancer; France; USA; Spain; Italy DO - http://dx.doi.org/10.1002/ijc.22712 ER - TY - JOUR T1 - Enhanced Sensitivity to Cholera Toxin in ADP-Ribosylarginine Hydrolase-Deficient Mice AN - 20637528; 7532365 AB - Cholera toxin (CT) produced by Vibrio cholerae causes the devastating diarrhea of cholera by catalyzing the ADP-ribosylation of the alpha subunit of the intestinal G sub(s) protein (G sub(s alpha )), leading to characteristic water and electrolyte losses. Mammalian cells contain ADP-ribosyltransferases similar to CT and an ADP-ribosyl(arginine)protein hydrolase (ADPRH), which cleaves the ADP-ribose-(arginine)protein bond, regenerating native protein and completing an ADP-ribosylation cycle. We hypothesized that ADPRH might counteract intoxication by reversing the ADP-ribosylation of G sub(s alpha ). Effects of intoxication on murine ADPRH super(-/-) cells were greater than those on wild-type cells and were significantly reduced by overexpression of wild-type ADPRH in ADPRH super(-/-) cells, as evidenced by both ADP-ribose-arginine content and G sub(s alpha ) modification. Similarly, intestinal loops in the ADPRH super(-/-) mouse were more sensitive than their wild-type counterparts to toxin effects on fluid accumulation, G sub(s alpha ) modification, and ADP-ribosylarginine content. Thus, CT-catalyzed ADP-ribosylation of cell proteins can be counteracted by ADPRH, which could function as a modifier gene in disease. Further, our study demonstrates that enzymatic cross talk exists between bacterial toxin ADP-ribosyltransferases and host ADP-ribosylation cycles. In disease, toxin-catalyzed ADP-ribosylation overwhelms this potential host defense system, resulting in persistence of ADP-ribosylation and intoxication of the cell. JF - Molecular and Cellular Biology AU - Kato, Jiro AU - Zhu, Jianfeng AU - Liu, Chengyu AU - Moss, Joel AD - Pulmonary-Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1590. Laboratory Research Program, Transgenic Mouse Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1590 Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 5534 EP - 5543 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 27 IS - 15 SN - 0270-7306, 0270-7306 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology KW - Intoxication KW - hydrolase KW - Vibrio cholerae KW - Diarrhea KW - Mammalian cells KW - NAD(P) super(+)-arginine ADP-ribosyltransferase KW - Cholera toxin KW - Intestine KW - Guanine nucleotide-binding protein KW - Cholera KW - ADP-ribosylation KW - X 24370:Natural Toxins KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20637528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biology&rft.atitle=Enhanced+Sensitivity+to+Cholera+Toxin+in+ADP-Ribosylarginine+Hydrolase-Deficient+Mice&rft.au=Kato%2C+Jiro%3BZhu%2C+Jianfeng%3BLiu%2C+Chengyu%3BMoss%2C+Joel&rft.aulast=Kato&rft.aufirst=Jiro&rft.date=2007-08-01&rft.volume=27&rft.issue=15&rft.spage=5534&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - hydrolase; Intoxication; Diarrhea; Mammalian cells; Cholera toxin; NAD(P) super(+)-arginine ADP-ribosyltransferase; Intestine; Guanine nucleotide-binding protein; Cholera; ADP-ribosylation; Vibrio cholerae ER - TY - JOUR T1 - High-throughput screening assays for the identification of chemical probes AN - 20635607; 7565441 AB - High-throughput screening (HTS) assays enable the testing of large numbers of chemical substances for activity in diverse areas of biology. The biological responses measured in HTS assays span isolated biochemical systems containing purified receptors or enzymes to signal transduction pathways and complex networks functioning in cellular environments. This Review addresses factors that need to be considered when implementing assays for HTS and is aimed particularly at investigators new to this field. We discuss assay design strategies, the major detection technologies and examples of HTS assays for common target classes, cellular pathways and simple cellular phenotypes. We conclude with special considerations for configuring sensitive, robust, informative and economically feasible HTS assays. JF - Nature Chemical Biology AU - Inglese, James AU - Johnson, Ronald L AU - Simeonov, Anton AU - Xia, Menghang AU - Zheng, Wei AU - Austin, Christopher P AU - Auld, Douglas S AD - US National Institutes of Health Chemical Genomics Center, National Institutes of Health, 9800 Medical Center Drive, Bethesda, Maryland 20892- 3370, USA., jinglese@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 466 EP - 479 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 3 IS - 8 SN - 1552-4450, 1552-4450 KW - Biotechnology and Bioengineering Abstracts KW - Reviews KW - Enzymes KW - high-throughput screening KW - Signal transduction KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20635607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Chemical+Biology&rft.atitle=High-throughput+screening+assays+for+the+identification+of+chemical+probes&rft.au=Inglese%2C+James%3BJohnson%2C+Ronald+L%3BSimeonov%2C+Anton%3BXia%2C+Menghang%3BZheng%2C+Wei%3BAustin%2C+Christopher+P%3BAuld%2C+Douglas+S&rft.aulast=Inglese&rft.aufirst=James&rft.date=2007-08-01&rft.volume=3&rft.issue=8&rft.spage=466&rft.isbn=&rft.btitle=&rft.title=Nature+Chemical+Biology&rft.issn=15524450&rft_id=info:doi/10.1038%2Fnchembio.2007.17 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Reviews; Enzymes; high-throughput screening; Signal transduction DO - http://dx.doi.org/10.1038/nchembio.2007.17 ER - TY - JOUR T1 - Comparing measures of acute bowel toxicity in patients with prostate cancer treated with external beam radiation therapy AN - 20541994; 8067564 AB - Purpose This study strives to compare early measures of bowel toxicity in patients with prostate cancer receiving definitive or adjuvant 3D conformal external beam radiation therapy and concurrent daily endorectal application of amifostine. Methods Eighteen patients were enrolled in the clinical study with a median follow-up of 12 months. Prescription doses ranged from 66 Gy to 76 Gy with a daily fractionation of 2 Gy. Acute bowel toxicity was measured at baseline, at Weeks 5 and 7 of radiotherapy, and at 1 and 3 months after the completion of therapy. Measures of acute bowel toxicity included the Radiation Therapy Oncology Group (RTOG) acute radiation morbidity scoring criteria, Expanded Prostate Cancer Index Composite (EPIC) self-assessment questionnaires, and proctoscopic examinations. Results The mean EPIC bowel scores changed significantly through the course of therapy and follow-up (p < 0.0001), with a progressive decrease in scores at Weeks 5 and 7 of treatment, a partial recovery at 3 months, and a correlation to the gold standard RTOG grade (p = 0.004). Proctoscopic toxicity scores were low, did not vary over time, and did not correlate with either EPIC or RTOG scores. Conclusion The EPIC questionnaire measurements are most sensitive to changes in acute bowel toxicity through a course of radiotherapy and correlate with RTOG acute toxicity scores. Endoscopic examination of the rectal mucosa at the end and immediate follow-up of a course of therapy does not seem to be informative or reproducible between observers in the acute setting. JF - International Journal of Radiation Oncology, Biology, & Physics AU - Muanza, Thierry M AU - Albert, Paul S AU - Smith, Sharon AU - Godette, Denise AU - Crouse, Nancy Sears AU - Cooley-Zgela, Theresa AU - Sciuto, Linda AU - Camphausen, Kevin AU - Coleman, C Norman AU - Menard, Cynthia AD - Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, cynthia.menard@rmp.uhn.on.ca Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 1316 EP - 1321 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 62 IS - 5 SN - 0360-3016, 0360-3016 KW - Toxicology Abstracts KW - Bowel toxicity KW - Radiation KW - Endoscopy KW - Prostate cancer KW - Inventories KW - Rectum KW - Amifostine KW - Mucosa KW - Radiotherapy KW - Oncology KW - Acute toxicity KW - Adjuvants KW - Self-assessment KW - Morbidity KW - Intestine KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20541994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Radiation+Oncology%2C+Biology%2C+%26+Physics&rft.atitle=Comparing+measures+of+acute+bowel+toxicity+in+patients+with+prostate+cancer+treated+with+external+beam+radiation+therapy&rft.au=Muanza%2C+Thierry+M%3BAlbert%2C+Paul+S%3BSmith%2C+Sharon%3BGodette%2C+Denise%3BCrouse%2C+Nancy+Sears%3BCooley-Zgela%2C+Theresa%3BSciuto%2C+Linda%3BCamphausen%2C+Kevin%3BColeman%2C+C+Norman%3BMenard%2C+Cynthia&rft.aulast=Muanza&rft.aufirst=Thierry&rft.date=2007-08-01&rft.volume=62&rft.issue=5&rft.spage=1316&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Radiation+Oncology%2C+Biology%2C+%26+Physics&rft.issn=03603016&rft_id=info:doi/10.1016%2Fj.ijrobp.2004.12.083 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Inventories; Rectum; Amifostine; Mucosa; Radiotherapy; Oncology; Self-assessment; Adjuvants; Acute toxicity; Morbidity; Prostate cancer; Radiation; Intestine DO - http://dx.doi.org/10.1016/j.ijrobp.2004.12.083 ER - TY - JOUR T1 - Imaging and manipulating phosphoinositides in living cells AN - 20513543; 8007802 AB - Phosphoinositides are minor phospholipid constituents of virtually every biological membrane yet they play fundamental roles in controlling membrane-bound signalling events. Phosphoinositides are produced from phosphatidylinositol (PtdIns) by phosphorylation of one or more of three positions (3, 4 and 5) of the inositol headgroup located at the membrane cytoplasmic interface by distinct families of inositol lipid kinases. Intriguingly, many of the kinase reactions are catalysed by more than one form of the kinases even in simple organisms and these enzymes often assume non-redundant functions. A similar diversity is seen with inositide phosphatases, the enzymes that dephosphorylate phosphoinositides with a certain degree of specificity and the impairments of which are often linked to human diseases. This degree of multiplicity at the enzyme level together with the universal roles of these lipids in cell regulation assumes that inositol lipids are spatially and functionally restricted in specific membrane compartments. Studying the compartmentalized roles of these lipids at the cellular level represents a major methodological challenge. Over the last 10 years significant progress has been made in creating reagents that can monitor inositol lipid changes in live cells with fluorescence or confocal microscopy. New methods are also being developed to manipulate these lipids in specific membrane compartments in a regulated fashion. This article recalls some historical aspects of inositide research and describes the new methodological advances highlighting their great potential as well as the problems one can encounter with their use. JF - Journal of Physiology (London) AU - Balla, Tamas AD - National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA, ballat@mail.nih.gov Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 927 EP - 937 PB - Cambridge University Press, The Edinburgh Building, VL - 582 IS - 3 SN - 0022-3751, 0022-3751 KW - Biotechnology Research Abstracts (through 1992) KW - Lipid kinase KW - Fluorescence KW - Phosphorylation KW - phosphatidylinositol KW - Computed tomography KW - Confocal microscopy KW - Inositol KW - Enzymes KW - phosphoinositides KW - Phospholipids KW - Signal transduction KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20513543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Physiology+%28London%29&rft.atitle=Imaging+and+manipulating+phosphoinositides+in+living+cells&rft.au=Balla%2C+Tamas&rft.aulast=Balla&rft.aufirst=Tamas&rft.date=2007-08-01&rft.volume=582&rft.issue=3&rft.spage=927&rft.isbn=&rft.btitle=&rft.title=Journal+of+Physiology+%28London%29&rft.issn=00223751&rft_id=info:doi/10.1113%2Fjphysiol.2007.132795 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Inositol; phosphoinositides; Enzymes; Lipid kinase; phosphatidylinositol; Confocal microscopy; Computed tomography; Signal transduction; Fluorescence; Phospholipids; Phosphorylation DO - http://dx.doi.org/10.1113/jphysiol.2007.132795 ER - TY - JOUR T1 - Immunological properties of engineered nanomaterials AN - 20504337; 7565628 AB - Most research on the toxicology of nanomaterials has focused on the effects of nanoparticles that enter the body accidentally. There has been much less research on the toxicology of nanoparticles that are used for biomedical applications, such as drug delivery or imaging, in which the nanoparticles are deliberately placed in the body. Moreover, there are no harmonized standards for assessing the toxicity of nanoparticles to the immune system (immunotoxicity). Here we review recent research on immunotoxicity, along with data on a range of nanotechnology-based drugs that are at different stages in the approval process. Research shows that nanoparticles can stimulate and/or suppress the immune responses, and that their compatibility with the immune system is largely determined by their surface chemistry. Modifying these factors can significantly reduce the immunotoxicity of nanoparticles and make them useful platforms for drug delivery. JF - Nature Nanotechnology AU - Dobrovolskaia, Marina A AU - McNeil, Scott E Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 469 EP - 478 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 2 IS - 8 SN - 1748-3387, 1748-3387 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Nanoparticles KW - Nanomedicine KW - Drug delivery KW - Immunotoxicity KW - Immune system KW - Reviews KW - nanoparticles KW - imaging KW - Immunosuppressive agents KW - nanotechnology KW - F 06955:Immunomodulation & Immunopharmacology KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20504337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Nanotechnology&rft.atitle=Immunological+properties+of+engineered+nanomaterials&rft.au=Dobrovolskaia%2C+Marina+A%3BMcNeil%2C+Scott+E&rft.aulast=Dobrovolskaia&rft.aufirst=Marina&rft.date=2007-08-01&rft.volume=2&rft.issue=8&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Nature+Nanotechnology&rft.issn=17483387&rft_id=info:doi/10.1038%2Fnnano.2007.223 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Drug delivery; Immunotoxicity; Reviews; Immune system; Immunosuppressive agents; imaging; nanoparticles; nanotechnology DO - http://dx.doi.org/10.1038/nnano.2007.223 ER - TY - JOUR T1 - Factors Associated with Retaliatory Attitudes among African American Adolescents Who have been Assaulted AN - 20435559; 7532185 AB - OBJECTIVE:s (a) To describe attitudes regarding retaliation among adolescents who have been assaulted. (b) To examine assault/event characteristics, personal, parental, and environmental factors associated with the retaliatory attitudes of adolescents who have been assaulted. METHODS:African American youth aged 10-15 years presenting to two large urban hospitals with peer assault injury and a parent/caregiver completed interviews in their home after their emergency department visit. RESULTS:Multivariate analyses revealed that lower SES, older age, and adolescents' perceptions that their parents support fighting were related to endorsing retaliatory attitudes. Girls who were aggressive were more likely to endorse retaliatory attitudes. However, level of aggression did not impact boys' retaliatory attitudes. Affiliating with aggressive peers influenced the retaliatory attitudes of boys, but did not influence girls' retaliatory attitudes. Overall, youths' perceptions of their parents' attitudes toward fighting had the greatest impact on retaliatory attitudes. CONCLUSIONS:Adolescents' perceptions of their parents' attitudes toward fighting may be a factor in subsequent re-injury among youth. Violence prevention and intervention efforts need to involve components that assess parental attitudes and incorporate strategies to engage parents in violence prevention efforts. In addition, interventions for youth who have been assaulted may need to incorporate some gender-specific components in order to address the unique needs of girls and boys. JF - Journal of Pediatric Psychology AU - Copeland-Linder, Nikeea AU - Jones, Vanya C AU - Haynie, Denise L AU - Simons-Morton, Bruce G AU - Wright, Joseph L AU - Cheng, Tina L AD - Johns Hopkins University School of Medicine & Johns Hopkins Bloomberg School of Public Health, Johns Hopkins Bloomberg School of Public Health, NICHD/PRB/DESPR/NIH, Children's National Medical Center, and Johns Hopkins University School of Medicine Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 760 EP - 770 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 32 IS - 7 SN - 0146-8693, 0146-8693 KW - retaliation KW - Risk Abstracts KW - Prevention KW - Gender KW - Violence KW - Ethnic groups KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20435559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pediatric+Psychology&rft.atitle=Factors+Associated+with+Retaliatory+Attitudes+among+African+American+Adolescents+Who+have+been+Assaulted&rft.au=Copeland-Linder%2C+Nikeea%3BJones%2C+Vanya+C%3BHaynie%2C+Denise+L%3BSimons-Morton%2C+Bruce+G%3BWright%2C+Joseph+L%3BCheng%2C+Tina+L&rft.aulast=Copeland-Linder&rft.aufirst=Nikeea&rft.date=2007-08-01&rft.volume=32&rft.issue=7&rft.spage=760&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pediatric+Psychology&rft.issn=01468693&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Prevention; Gender; Violence; Ethnic groups ER - TY - JOUR T1 - Does cannabis use predict the first incidence of mood and anxiety disorders in the adult population? AN - 20418257; 7884081 AB - Aims To investigate whether cannabis use predicted the first incidence of mood and anxiety disorders in adults during a 3-year follow-up period. Design and participants Data were derived from the Netherlands Mental Health Survey and Incidence Study (NEMESIS), a prospective study in the adult population of 18-64 years. The analysis was carried out on 3881 people who had no life-time mood disorders and on 3854 people who had no life-time anxiety disorders at baseline. Measurements Life-time cannabis use and DSM-III-R mood and anxiety disorders, assessed with the Composite International Diagnostic Interview (CIDI). Findings After adjustment for strong confounders, any use of cannabis at baseline predicted a modest increase in the risk of a first major depression (odds ratio 1.62; 95% confidence interval 1.06-2.48) and a stronger increase in the risk of a first bipolar disorder (odds ratio 4.98; 95% confidence interval 1.80-13.81). The risk of 'any mood disorder' was elevated for weekly and almost daily users but not for less frequent use patterns. However, dose-response relationships were less clear for major depression and bipolar disorder separately. None of the associations between cannabis use and anxiety disorders remained significant after adjustment for confounders. Conclusions The associations between cannabis use and the first incidence of depression and bi