TY - JOUR T1 - Nonpsychoactive Cannabidiol Prevents Prion Accumulation and Protects Neurons against Prion Toxicity AN - 20699493; 7615300 AB - Prion diseases are transmissible neurodegenerative disorders characterized by the accumulation in the CNS of the protease-resistant prion protein (PrPres), a structurally misfolded isoform of its physiological counterpart PrPsen. Both neuropathogenesis and prion infectivity are related to PrPres formation. Here, we report that the nonpsychoactive cannabis constituent cannabidiol (CBD) inhibited PrPres accumulation in both mouse and sheep scrapie-infected cells, whereas other structurally related cannabinoid analogs were either weak inhibitors or noninhibitory. Moreover, after intraperitoneal infection with murine scrapie, peripheral injection of CBD limited cerebral accumulation of PrPres and significantly increased the survival time of infected mice. Mechanistically, CBD did not appear to inhibit PrPres accumulation via direct interactions with PrP, destabilization of PrPres aggregates, or alteration of the expression level or subcellular localization of PrPsen. However, CBD did inhibit the neurotoxic effects of PrPres and affected PrPres-induced microglial cell migration in a concentration-dependent manner. Our results suggest that CBD may protect neurons against the multiple molecular and cellular factors involved in the different steps of the neurodegenerative process, which takes place during prion infection. When combined with its ability to target the brain and its lack of toxic side effects, CBD may represent a promising new anti-prion drug. JF - Journal of Neuroscience AU - Dirikoc, Sevda AU - Priola, Suzette A AU - Marella, Mathieu AU - Zsuerger, Nicole AU - Chabry, Joelle AD - Institut de Pharmacologie Moleculaire et Cellulaire, Unite Mixte de Recherche 6097, Centre National de la Recherche Scientifique, 06560 Valbonne, France, Laboratory of Persistent Viral Diseases, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, Hamilton, Montana 59840, and Scripps Research Institute, La Jolla, California 92037 Y1 - 2007/09/05/ PY - 2007 DA - 2007 Sep 05 SP - 9537 EP - 9544 PB - Society for Neuroscience, 11 Dupont Circle, N.W. Suite 500 Washington DC 20036 USA, [mailto:info@sfn.org], [URL:http://apu.sfn.org/] VL - 27 IS - 36 SN - 0270-6474, 0270-6474 KW - Toxicology Abstracts; Virology & AIDS Abstracts; CSA Neurosciences Abstracts KW - Central nervous system KW - Neuropathogenesis KW - Brain KW - Scrapie KW - Toxicity KW - Infection KW - Drug abuse KW - Neurodegenerative diseases KW - Infectivity KW - Nervous system KW - Cannabinoids KW - Neurons KW - Neurotoxicity KW - Prion protein KW - Cannabis KW - Cell migration KW - Microglial cells KW - Side effects KW - X 24380:Social Poisons & Drug Abuse KW - N3 11028:Neuropharmacology & toxicology KW - V 22380:Prions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20699493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=Nonpsychoactive+Cannabidiol+Prevents+Prion+Accumulation+and+Protects+Neurons+against+Prion+Toxicity&rft.au=Dirikoc%2C+Sevda%3BPriola%2C+Suzette+A%3BMarella%2C+Mathieu%3BZsuerger%2C+Nicole%3BChabry%2C+Joelle&rft.aulast=Dirikoc&rft.aufirst=Sevda&rft.date=2007-09-05&rft.volume=27&rft.issue=36&rft.spage=9537&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Central nervous system; Brain; Neuropathogenesis; Toxicity; Scrapie; Drug abuse; Infection; Neurodegenerative diseases; Nervous system; Infectivity; Cannabinoids; Neurons; Neurotoxicity; Cannabis; Prion protein; Cell migration; Microglial cells; Side effects ER - TY - JOUR T1 - Short-term and long-term effects of postnatal exposure to an adult male in C57BL/6J mice. AN - 68106178; 17482287 AB - Rodent models provide a valuable approach to elucidating the pathophysiological mechanisms underlying the deleterious effects of childhood trauma and stress. Neonatal rats and mice emit ultrasonic vocalizations (USVs) when separated from the dam and litter. USVs are suppressed in rat pups by exposure to the putatively infanticidal threat of an adult male. In the present study, C57BL/6J mouse pups were exposed to an anaesthetized (non-sire) adult C57BL/6J male for 3-min/day from postnatal days 2-14, and subsequently tested for anxiety-related behaviors (using the novel open field, elevated plus-maze, light/dark exploration tests) and depression-related behavior (using the forced swim test) at 11 weeks of age. In a separate cohort, hypothalamic-pituitary-adrenal-axis activation was measured via plasma corticosterone levels following either a single male-exposure or separation episode. Results showed that pups exposed to an adult male emitted significantly fewer USVs than separation-only counterparts. Corticosterone levels were significantly lower following single exposure to the adult male than separation alone. Repeated neonatal male-exposure did not lead to significant alterations in anxiety- or depression-related behaviors in adulthood. Taken together, present data suggest that the form of adult male-exposure employed did not act as a significant stressor, at least in this mouse strain. Further studies will be needed to determine whether alternative mouse strains, exposure protocols or adult behavioral assays will produce a different pattern of short-term and long-term effects. JF - Behavioural brain research AU - Hefner, Kathryn AU - Cameron, Heather A AU - Karlsson, Rose-Marie AU - Holmes, Andrew AD - Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, NIH, Rockville, MD 20852-9411, USA. Y1 - 2007/09/04/ PY - 2007 DA - 2007 Sep 04 SP - 344 EP - 348 VL - 182 IS - 2 SN - 0166-4328, 0166-4328 KW - Analgesics KW - 0 KW - Corticosterone KW - W980KJ009P KW - Index Medicus KW - Animals KW - Maze Learning -- drug effects KW - Analysis of Variance KW - Age Factors KW - Maze Learning -- physiology KW - Corticosterone -- blood KW - Mice KW - Dose-Response Relationship, Radiation KW - Acoustic Stimulation -- methods KW - Time Factors KW - Male KW - Animals, Newborn -- physiology KW - Vocalization, Animal -- drug effects KW - Behavior, Animal -- drug effects KW - Vocalization, Animal -- physiology KW - Ultrasonics KW - Mice, Inbred C57BL -- physiology KW - Analgesics -- pharmacology KW - Behavior, Animal -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68106178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+brain+research&rft.atitle=Short-term+and+long-term+effects+of+postnatal+exposure+to+an+adult+male+in+C57BL%2F6J+mice.&rft.au=Hefner%2C+Kathryn%3BCameron%2C+Heather+A%3BKarlsson%2C+Rose-Marie%3BHolmes%2C+Andrew&rft.aulast=Hefner&rft.aufirst=Kathryn&rft.date=2007-09-04&rft.volume=182&rft.issue=2&rft.spage=344&rft.isbn=&rft.btitle=&rft.title=Behavioural+brain+research&rft.issn=01664328&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-26 N1 - Date created - 2007-07-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of the nonreducing end of Shigella dysenteriae type 1 O-specific oligosaccharides on their immunogenicity as conjugates in mice AN - 20300772; 7616672 AB - Endemic and epidemic shigellosis, an acute invasive disease of the lower intestines, afflicts millions of people worldwide with an estimated one million fatalities per annum at a low infectious dose. Our approach to vaccine development against Shigella is based on the hypothesis that serum IgG antibodies to the O-specific polysaccharide (O-SP) domains of the LPS of these organisms confer protection to infection. The synthetic oligosaccharides corresponding to the tetrasaccharide repeating unit of the O-SP of Shigella dysenteriae type 1 covalently linked to human serum albumin elicited O-SP-specific IgG in mice. The antibody levels were a function of both the saccharide chain length and their loading on the protein. These synthetic saccharide conjugates elicited significantly higher levels of IgG anti O-SP than conjugates prepared with the O-SP from the bacteria. Here, we evaluated the influence of the nonreducing terminal monosaccharide on the serum antibody response. To this end, we prepared synthetic oligosaccharides comprising hexa- to tridecasaccharide fragments of the native O-SP, having one of the four monosaccharide residues that constitute the repeating unit at their termini and bound them to BSA by a single-point attachment. The conjugates contained an average of 19 saccharide chains per BSA. The synthetic oligosaccharides inhibited the binding of serum raised against whole bacteria to its LPS to a similar extent but lower than the native O-SP. The highest anti-LPS levels were elicited by conjugates having N-acetylglucosamine (10-mer) or galactose residues (7- and 11-mers) at their nonreducing termini. JF - Proceedings of the National Academy of Sciences, USA AU - Pozsgay, Vince AU - Kubler-Kielb, Joanna AU - Schneerson, Rachel AU - Robbins, John B AD - Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-2423 Y1 - 2007/09/04/ PY - 2007 DA - 2007 Sep 04 SP - 14478 EP - 14482 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 36 SN - 0027-8424, 0027-8424 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Galactose KW - Epidemics KW - oligosaccharides KW - human serum albumin KW - Shigella KW - Antibody response KW - monosaccharides KW - N-Acetylglucosamine KW - Polysaccharides KW - Infection KW - Shigella dysenteriae KW - Immunogenicity KW - Shigellosis KW - Intestine KW - Immunoglobulin G KW - Lipopolysaccharides KW - Vaccines KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20300772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Effect+of+the+nonreducing+end+of+Shigella+dysenteriae+type+1+O-specific+oligosaccharides+on+their+immunogenicity+as+conjugates+in+mice&rft.au=Pozsgay%2C+Vince%3BKubler-Kielb%2C+Joanna%3BSchneerson%2C+Rachel%3BRobbins%2C+John+B&rft.aulast=Pozsgay&rft.aufirst=Vince&rft.date=2007-09-04&rft.volume=104&rft.issue=36&rft.spage=14478&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Galactose; oligosaccharides; Epidemics; human serum albumin; N-Acetylglucosamine; monosaccharides; Antibody response; Infection; Polysaccharides; Shigellosis; Immunogenicity; Immunoglobulin G; Intestine; Lipopolysaccharides; Vaccines; Shigella; Shigella dysenteriae ER - TY - JOUR T1 - Blood leukocyte microarrays to diagnose systemic onset juvenile idiopathic arthritis and follow the response to IL-1 blockade AN - 20078297; 7558391 AB - Systemic onset juvenile idiopathic arthritis (SoJIA) represents up to 20% of juvenile idiopathic arthritis. We recently reported that interleukin (IL) 1 is an important mediator of this disease and that IL-1 blockade induces clinical remission. However, lack of specificity of the initial systemic manifestations leads to delays in diagnosis and initiation of therapy. To develop a specific diagnostic test, we analyzed leukocyte gene expression profiles of 44 pediatric SoJIA patients, 94 pediatric patients with acute viral and bacterial infections, 38 pediatric patients with systemic lupus erythematosus (SLE), 6 patients with PAPA syndrome, and 39 healthy children. Statistical group comparison and class prediction identified genes differentially expressed in SoJIA patients compared with healthy children. These genes, however, were also changed in patients with acute infections and SLE. An analysis of significance across all diagnostic groups identified 88 SoJIA-specific genes, 12 of which accurately classified an independent set of SoJIA patients with systemic disease. Transcripts that changed significantly in patients undergoing IL-1 blockade were also identified. Thus, leukocyte transcriptional signatures can be used to distinguish SoJIA from other febrile illnesses and to assess response to therapy. Availability of early diagnostic markers may allow prompt initiation of therapy and prevention of disabilities. JF - Journal of Experimental Medicine AU - Allantaz, Florence AU - Chaussabel, Damien AU - Stichweh, Dorothee AU - Bennett, Lynda AU - Allman, Windy AU - Mejias, Asuncion AU - Ardura, Monica AU - Chung, Wendy AU - Wise, Carol AU - Palucka, Karolina AU - Ramilo, Octavio AU - Punaro, Marilynn AU - Banchereau, Jacques AU - Pascual, Virginia AD - Baylor National Institute of Allergy and Infectious Diseases Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX 75204. Baylor Institute for Immunology Research, Dallas, TX 75204. Division of Pediatric Infectious Diseases and Division of Pediatric Rheumatology, UT Southwestern Medical Center, Dallas, TX 75390. Texas Scottish Rite Hospital, Dallas, TX 75219 Y1 - 2007/09/03/ PY - 2007 DA - 2007 Sep 03 SP - 2131 EP - 2144 PB - Rockefeller University Press, 1114 First Avenue New York NY 10021-8325 USA, [mailto:Bruce.Lyons@rockefeller.edu], [URL:http://www.rockefeller.edu/rupress] VL - 204 IS - 9 SN - 0022-1007, 0022-1007 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Statistics KW - Pediatrics KW - Leukocytes KW - Interleukin 1 KW - Transcription KW - Remission KW - Children KW - Infection KW - DNA microarrays KW - Gene expression KW - Blood KW - Arthritis KW - Systemic lupus erythematosus KW - J 02400:Human Diseases KW - F 06930:Autoimmunity KW - W 30900:Methods KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20078297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Medicine&rft.atitle=Blood+leukocyte+microarrays+to+diagnose+systemic+onset+juvenile+idiopathic+arthritis+and+follow+the+response+to+IL-1+blockade&rft.au=Allantaz%2C+Florence%3BChaussabel%2C+Damien%3BStichweh%2C+Dorothee%3BBennett%2C+Lynda%3BAllman%2C+Windy%3BMejias%2C+Asuncion%3BArdura%2C+Monica%3BChung%2C+Wendy%3BWise%2C+Carol%3BPalucka%2C+Karolina%3BRamilo%2C+Octavio%3BPunaro%2C+Marilynn%3BBanchereau%2C+Jacques%3BPascual%2C+Virginia&rft.aulast=Allantaz&rft.aufirst=Florence&rft.date=2007-09-03&rft.volume=204&rft.issue=9&rft.spage=2131&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Medicine&rft.issn=00221007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Statistics; Pediatrics; Interleukin 1; Leukocytes; Remission; Transcription; Infection; Children; DNA microarrays; Gene expression; Blood; Arthritis; Systemic lupus erythematosus ER - TY - CPAPER T1 - Carcinosarcoma of the Lung with Soft Tissues Metastases. A Case Report T2 - 12th World Conference on Lung Cancer AN - 39543436; 4651323 JF - 12th World Conference on Lung Cancer AU - Parra, Luis Dominguez Y1 - 2007/09/02/ PY - 2007 DA - 2007 Sep 02 KW - Lung KW - Soft tissues KW - Case reports KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39543436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+World+Conference+on+Lung+Cancer&rft.atitle=Carcinosarcoma+of+the+Lung+with+Soft+Tissues+Metastases.+A+Case+Report&rft.au=Parra%2C+Luis+Dominguez&rft.aulast=Parra&rft.aufirst=Luis&rft.date=2007-09-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.2007worldlungcancer.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevalence and Pattern of Lymph Node Metastasis in Malignant Pleural Mesothelioma T2 - 12th World Conference on Lung Cancer AN - 39474904; 4651313 JF - 12th World Conference on Lung Cancer AU - Rahman, Mohamed Abdel Y1 - 2007/09/02/ PY - 2007 DA - 2007 Sep 02 KW - Lymph nodes KW - Mesothelioma KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39474904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+World+Conference+on+Lung+Cancer&rft.atitle=Prevalence+and+Pattern+of+Lymph+Node+Metastasis+in+Malignant+Pleural+Mesothelioma&rft.au=Rahman%2C+Mohamed+Abdel&rft.aulast=Rahman&rft.aufirst=Mohamed&rft.date=2007-09-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.2007worldlungcancer.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Number of Surgically Removed Mediastinal Lymph-Nodes (SRMLNs) as Prognostic Factor for Survival in Resected Early Stage Non-Small-Cell Lung Cancer (NSCLC): A Retrospective Analysis of a Mono-Institutional Series T2 - 12th World Conference on Lung Cancer AN - 39445226; 4652024 JF - 12th World Conference on Lung Cancer AU - Alessandrini, Gabriele Y1 - 2007/09/02/ PY - 2007 DA - 2007 Sep 02 KW - Lung cancer KW - Survival KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39445226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+World+Conference+on+Lung+Cancer&rft.atitle=Number+of+Surgically+Removed+Mediastinal+Lymph-Nodes+%28SRMLNs%29+as+Prognostic+Factor+for+Survival+in+Resected+Early+Stage+Non-Small-Cell+Lung+Cancer+%28NSCLC%29%3A+A+Retrospective+Analysis+of+a+Mono-Institutional+Series&rft.au=Alessandrini%2C+Gabriele&rft.aulast=Alessandrini&rft.aufirst=Gabriele&rft.date=2007-09-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.2007worldlungcancer.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Promotion of Squamous Differentiation and Tumorigenesis in Mouse Lung Expressing Human Keratin 14 T2 - 12th World Conference on Lung Cancer AN - 39430599; 4651120 JF - 12th World Conference on Lung Cancer AU - Linnoila, Ilona Y1 - 2007/09/02/ PY - 2007 DA - 2007 Sep 02 KW - Lung KW - Tumorigenesis KW - Differentiation KW - Keratin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39430599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+World+Conference+on+Lung+Cancer&rft.atitle=Promotion+of+Squamous+Differentiation+and+Tumorigenesis+in+Mouse+Lung+Expressing+Human+Keratin+14&rft.au=Linnoila%2C+Ilona&rft.aulast=Linnoila&rft.aufirst=Ilona&rft.date=2007-09-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.2007worldlungcancer.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of SV-40 as a Biological Prognostic Factor in Egyptian Patients with Malignant Pleural Mesothelioma T2 - 12th World Conference on Lung Cancer AN - 39427415; 4651314 JF - 12th World Conference on Lung Cancer AU - Bahnassy, Abeer Y1 - 2007/09/02/ PY - 2007 DA - 2007 Sep 02 KW - Mesothelioma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39427415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+World+Conference+on+Lung+Cancer&rft.atitle=Evaluation+of+SV-40+as+a+Biological+Prognostic+Factor+in+Egyptian+Patients+with+Malignant+Pleural+Mesothelioma&rft.au=Bahnassy%2C+Abeer&rft.aulast=Bahnassy&rft.aufirst=Abeer&rft.date=2007-09-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.2007worldlungcancer.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pulmonary Metastases from a Giant Tumor Cell of Bone. A Case Report T2 - 12th World Conference on Lung Cancer AN - 39413614; 4651324 JF - 12th World Conference on Lung Cancer AU - Dominguez-Parra, Luis Y1 - 2007/09/02/ PY - 2007 DA - 2007 Sep 02 KW - Bone KW - Tumor cells KW - Lung KW - Case reports KW - Metastases KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39413614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+World+Conference+on+Lung+Cancer&rft.atitle=Pulmonary+Metastases+from+a+Giant+Tumor+Cell+of+Bone.+A+Case+Report&rft.au=Dominguez-Parra%2C+Luis&rft.aulast=Dominguez-Parra&rft.aufirst=Luis&rft.date=2007-09-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.2007worldlungcancer.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nuclear and Cytoplasmic Cellular Distribution of Survivin as Survival Predictor in Resected Non-Small-Cell Lung Cancer. T2 - 12th World Conference on Lung Cancer AN - 39373853; 4651369 JF - 12th World Conference on Lung Cancer AU - Bria, Emilio Y1 - 2007/09/02/ PY - 2007 DA - 2007 Sep 02 KW - Lung cancer KW - Survival KW - Survivin KW - Cell survival KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39373853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=12th+World+Conference+on+Lung+Cancer&rft.atitle=Nuclear+and+Cytoplasmic+Cellular+Distribution+of+Survivin+as+Survival+Predictor+in+Resected+Non-Small-Cell+Lung+Cancer.&rft.au=Bria%2C+Emilio&rft.aulast=Bria&rft.aufirst=Emilio&rft.date=2007-09-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=12th+World+Conference+on+Lung+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.2007worldlungcancer.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Brain temperature fluctuations during physiological and pathological conditions AN - 883013301; 14082004 AB - This review discusses brain temperature as a physiological parameter, which is determined primarily by neural metabolism, regulated by cerebral blood flow, and affected by various environmental factors and drugs. First, we consider normal fluctuations in brain temperature that are induced by salient environmental stimuli and occur during motivated behavior at stable normothermic conditions. Second, we analyze changes in brain temperature induced by various drugs that affect brain and body metabolism and heat dissipation. Third, we consider how these physiological and drug-induced changes in brain temperature are modulated by environmental conditions that diminish heat dissipation. Our focus is psychomotor stimulant drugs and brain hyperthermia as a factor inducing or potentiating neurotoxicity. Finally, we discuss how brain temperature is regulated, what changes in brain temperature reflect, and how these changes may affect neural functions under normal and pathological conditions. Although most discussed data were obtained in animals and several important aspects of brain temperature regulation in humans remain unknown, our focus is on the relevance of these data for human physiology and pathology. JF - European Journal of Applied Physiology AU - Kiyatkin, Eugene A AD - Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, DHHS, 333 Cassell Drive, Baltimore, MD, 21224, USA, ekiyatki@intra.nida.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 3 EP - 17 PB - Springer-Verlag, P.O. Box 2485 Secaucus NJ 07096-2485 USA VL - 101 IS - 1 SN - 1439-6319, 1439-6319 KW - Physical Education Index; Toxicology Abstracts; CSA Neurosciences Abstracts KW - Hyperthermia KW - Body temperature KW - Physiology KW - Environmental factors KW - Blood flow KW - Environmental effects KW - Stimuli KW - Drugs KW - Temperature effects KW - Data processing KW - Motivation KW - Brain KW - Psychomotor stimulants KW - Heat KW - Analysis KW - Neurotoxicity KW - Environmental conditions KW - Cerebral blood flow KW - Metabolism KW - X 24310:Pharmaceuticals KW - N3 11028:Neuropharmacology & toxicology KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883013301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Applied+Physiology&rft.atitle=Brain+temperature+fluctuations+during+physiological+and+pathological+conditions&rft.au=Kiyatkin%2C+Eugene+A&rft.aulast=Kiyatkin&rft.aufirst=Eugene&rft.date=2007-09-01&rft.volume=101&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Applied+Physiology&rft.issn=14396319&rft_id=info:doi/10.1007%2Fs00421-007-0450-7 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Hyperthermia; Blood flow; Heat; Analysis; Physiology; Brain; Stimuli; Drugs; Metabolism; Temperature effects; Data processing; Body temperature; Motivation; Psychomotor stimulants; Environmental factors; Neurotoxicity; Environmental effects; Environmental conditions; Cerebral blood flow DO - http://dx.doi.org/10.1007/s00421-007-0450-7 ER - TY - JOUR T1 - Nerve growth factor potentiates p53 DNA binding but inhibits nitric oxide-induced apoptosis in neuronal PC12 cells. AN - 70768386; 17592775 AB - NGF is recognized for its role in neuronal differentiation and maintenance. Differentiation of PC12 cells by NGF involves p53, a transcription factor that controls growth arrest and apoptosis. We investigated NGF influence over p53 activity during NO-induced apoptosis by sodium nitroprusside in differentiated and mitotic PC12 cells. NGF-differentiation produced increased p53 levels, nuclear localization and sequence-specific DNA binding. Apoptosis in mitotic cells also produced these events but the accompanying activation of caspases 1-10 and mitochondrial depolarization were inhibited during NGF differentiation and could be reversed in p53-silenced cells. Transcriptional regulation of PUMA and survivin expression were not inhibited by NGF, although NO-induced mitochondrial depolarization was dependent upon de novo gene transcription and only occurred in mitotic cells. We conclude that NGF mediates prosurvival signaling by increasing factors such as Bcl-2 and p21(Waf1/Cip1) without altering p53 transcriptional activity to inhibit mitochondrial depolarization, caspase activation and apoptosis. JF - Neurochemical research AU - Brynczka, Christopher AU - Merrick, Bruce Alex AD - National Center for Toxicogenomics, National Institute of Environmental Health Sciences, National Institutes of Health, P.O. Box 12233, Research Triangle Park, NC 27709, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 1573 EP - 1585 VL - 32 IS - 9 SN - 0364-3190, 0364-3190 KW - Tumor Suppressor Protein p53 KW - 0 KW - Nitroprusside KW - 169D1260KM KW - Nitric Oxide KW - 31C4KY9ESH KW - DNA KW - 9007-49-2 KW - Nerve Growth Factor KW - 9061-61-4 KW - Caspases KW - EC 3.4.22.- KW - Index Medicus KW - Rats KW - Signal Transduction -- physiology KW - Animals KW - Membrane Potential, Mitochondrial -- drug effects KW - Cell Survival -- drug effects KW - Enzyme Activation KW - Nitric Oxide -- pharmacology KW - Nitroprusside -- pharmacology KW - Drug Synergism KW - Cell Differentiation -- drug effects KW - Caspases -- metabolism KW - PC12 Cells KW - DNA -- metabolism KW - Apoptosis -- drug effects KW - Nerve Growth Factor -- physiology KW - Tumor Suppressor Protein p53 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70768386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemical+research&rft.atitle=Nerve+growth+factor+potentiates+p53+DNA+binding+but+inhibits+nitric+oxide-induced+apoptosis+in+neuronal+PC12+cells.&rft.au=Simmons%2C+W+Kyle%3BMatlis%2C+Sean%3BBellgowan%2C+Patrick+S.F.%3BBodurka%2C+Jerzy%3BBarsalou%2C+Lawrence+W%3BMartin%2C+Alex&rft.aulast=Simmons&rft.aufirst=W&rft.date=2007-05-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-09 N1 - Date created - 2007-07-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2002 Mar 15;62(6):1648-53 [11912135] Atherosclerosis. 2002 May;162(1):93-101 [11947902] Oncogene. 2002 Apr 18;21(17):2613-22 [11965534] Ann N Y Acad Sci. 2002 May;962:318-31 [12076984] Nat Rev Cancer. 2002 Aug;2(8):594-604 [12154352] Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10364-9 [12136132] J Biol Chem. 2002 Oct 4;277(40):37949-54 [12151395] J Pharmacol Exp Ther. 2003 Jan;304(1):1-7 [12490568] Neurobiol Dis. 2003 Feb;12(1):35-45 [12609487] J Biol Chem. 2003 Apr 18;278(16):13898-904 [12578834] Ann Med. 2003;35(1):21-7 [12693609] Biochem Biophys Res Commun. 2003 Jun 6;305(3):776-83 [12763060] J Neurosci. 1996 Apr 1;16(7):2325-34 [8601812] J Cell Sci. 1996 Feb;109 ( Pt 2):289-300 [8838652] Oncogene. 2003 May 15;22(19):2857-68 [12771937] Exp Neurol. 2003 Jun;181(2):115-29 [12781986] Chem Res Toxicol. 2003 Aug;16(8):1004-13 [12924928] J Neurochem. 2003 Sep;86(6):1553-63 [12950464] Neurosci Lett. 2004 Jan 16;354(3):213-6 [14700734] Science. 2004 Feb 13;303(5660):1010-4 [14963330] J Neurochem. 2004 May;89(4):812-21 [15140181] J Biol Chem. 2004 Jul 23;279(30):30983-93 [15133027] Proc Natl Acad Sci U S A. 1976 Jul;73(7):2424-8 [1065897] Nature. 1990 Oct 25;347(6295):768-70 [1700301] Cell. 1991 Apr 5;65(1):189-97 [1849459] Cancer Res. 1994 Mar 1;54(5):1169-74 [8118801] Nature. 1996 Nov 28;384(6607):368-72 [8934524] Neurochem Int. 1996 Nov;29(5):461-7 [8939456] Biochem Biophys Res Commun. 1996 Dec 13;229(2):653-7 [8954953] J Neurosci Res. 1997 Aug 15;49(4):461-74 [9285522] Cell. 1997 Oct 31;91(3):325-34 [9363941] Biochem Biophys Res Commun. 1997 Nov 17;240(2):419-24 [9388494] Oncogene. 1998 Feb 19;16(7):825-32 [9484773] Eur J Biochem. 1998 Jan 15;251(1-2):195-200 [9492284] J Neurosci. 1998 Apr 15;18(8):2933-43 [9526010] Ann Neurol. 1998 Sep;44(3 Suppl 1):S115-20 [9749582] Brain Res Mol Brain Res. 1999 Feb 5;64(2):165-78 [9931481] Biochim Biophys Acta. 1999 Aug 5;1428(2-3):357-71 [10434055] Neurosci Lett. 1999 Jul 23;270(1):45-8 [10454142] Mol Cell Neurosci. 2004 Nov;27(3):322-31 [15519246] Mol Cells. 2004 Dec 31;18(3):353-9 [15650333] Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1339-44 [15677324] Toxicology. 2005 Mar 15;208(2):177-92 [15691583] Biochem Biophys Res Commun. 2005 Jun 10;331(3):851-8 [15865941] Curr Alzheimer Res. 2005 Apr;2(2):167-9 [15974914] Cell Death Differ. 2005 Aug;12(8):1066-77 [15877105] Carcinogenesis. 2005 Aug;26(8):1317-22 [15888490] Free Radic Biol Med. 2005 Oct 1;39(7):890-9 [16140209] Cell Cycle. 2005 Sep;4(9):1286-93 [16082214] Biochem Biophys Res Commun. 2006 Apr 14;342(3):984-90 [16598857] Oncogene. 2006 Apr 6;25(15):2203-12 [16288207] Brain Res. 2006 Apr 21;1084(1):1-15 [16564033] EMBO J. 2006 May 17;25(10):2083-95 [16642037] Bioessays. 2006 Jun;28(6):583-94 [16700063] J Neurosci Res. 2006 Jul;84(1):78-96 [16625660] Cell Death Differ. 2006 Aug;13(8):1396-402 [16710362] EMBO J. 2006 Sep 6;25(17):4084-96 [16946709] Brain Res. 2006 Sep 27;1112(1):1-15 [16901471] Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1693-705 [16987022] Cell Death Differ. 2006 Dec;13(12):2118-28 [16729028] J Biol Chem. 2006 Dec 1;281(48):36603-12 [17020887] Cancer Res. 2006 Dec 1;66(23):11254-62 [17145870] Mutat Res. 2007 Jan 3;614(1-2):24-36 [16879837] J Biol Chem. 2000 Mar 24;275(12):8817-24 [10722727] J Biol Chem. 2000 Apr 14;275(15):10761-6 [10753867] Crit Care Med. 2000 Apr;28(4 Suppl):N37-52 [10807315] Arch Neurol. 2000 Jun;57(6):846-51 [10867782] J Neurochem. 2000 Oct;75(4):1455-64 [10987825] J Biol Chem. 2000 Dec 1;275(48):37829-37 [10978315] Exp Cell Res. 2001 Jan 15;262(2):170-9 [11139341] Nat Rev Mol Cell Biol. 2000 Nov;1(2):120-9 [11253364] Blood. 2001 Jul 15;98(2):405-13 [11435310] Annu Rev Neurosci. 2001;24:1217-81 [11520933] Cell Death Differ. 2001 Sep;8(9):909-20 [11526446] J Biol Chem. 2002 Feb 1;277(5):3247-57 [11714700] Science. 2002 Mar 8;295(5561):1901-4 [11884757] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Substitution of oral and intravenous thioguanine for mercaptopurine in a treatment regimen for children with standard risk acute lymphoblastic leukemia: a collaborative Children's Oncology Group/National Cancer Institute pilot trial (CCG-1942). AN - 70763079; 16856155 AB - Although mercaptopurine (MP) is conventionally used to treat childhood acute lymphoblastic leukemia (ALL), thioguanine (TG) is a more potent thiopurine in vitro and, when administered orally to patients, achieves cytotoxic drug concentrations in the cerebrospinal fluid (CSF). We performed a pilot study incorporating oral and 24-hr continuous IV infusion (CIVI) TG in children with newly diagnosed standard-risk ALL. Children with newly diagnosed standard-risk ALL (age 1-10 years, WBC<50 k) were eligible. Multi-agent chemotherapy was patterned after the Children's Cancer Group (CCG) 105 trial, with the addition of CIVI-TG (480 mg/m2) during consolidation, interim maintenance and maintenance, and substitution of oral TG (60 mg/m2/day) for oral MP during maintenance. Fifty-eight patients (31 female), median age 4.3 years, were enrolled. At 8 years, the relapse-free and overall survival probabilities were 83% and 88%. There were no CNS relapses. Six patients (five males) experienced reversible veno-occlusive disease (VOD) while receiving oral TG, and the study was amended to discontinue TG, changing all patients to oral MP. Red cell TG nucleotide concentrations during oral TG averaged 95 ng (570 pmol)/8x10(8) RBC, greater than concentrations reported with oral MP. Although the absence of CNS relapses in this pilot study suggests that TG may contribute to the prevention of CNS recurrences, the development of VOD negatively impacts the risk:benefit ratio of substituting TG for MP. Copyright (c) 2006 Wiley-Liss, Inc. JF - Pediatric blood & cancer AU - Jacobs, Shana S AU - Stork, Linda C AU - Bostrom, Bruce C AU - Hutchinson, Ray AU - Holcenberg, John AU - Reaman, Gregory H AU - Erdmann, Gary AU - Franklin, Janet AU - Neglia, Joseph P AU - Steinberg, Seth M AU - Balis, Frank M AU - Adamson, Peter C AU - Children's Oncology Group AU - National Cancer Institute AD - Children's National Medical Center, Washington, District of Columbia, USA. jacobss@mail.nih.gov ; Children's Oncology Group ; National Cancer Institute Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 250 EP - 255 VL - 49 IS - 3 SN - 1545-5009, 1545-5009 KW - Antimetabolites, Antineoplastic KW - 0 KW - Thioguanine KW - FTK8U1GZNX KW - Index Medicus KW - Administration, Oral KW - Infusions, Intravenous KW - Drug-Related Side Effects and Adverse Reactions KW - Humans KW - Child KW - Pilot Projects KW - Child, Preschool KW - Infant KW - Hepatic Veno-Occlusive Disease -- chemically induced KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Female KW - Male KW - Survival Analysis KW - Antimetabolites, Antineoplastic -- administration & dosage KW - Thioguanine -- administration & dosage KW - Antimetabolites, Antineoplastic -- adverse effects KW - Thioguanine -- adverse effects KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70763079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+blood+%26+cancer&rft.atitle=Substitution+of+oral+and+intravenous+thioguanine+for+mercaptopurine+in+a+treatment+regimen+for+children+with+standard+risk+acute+lymphoblastic+leukemia%3A+a+collaborative+Children%27s+Oncology+Group%2FNational+Cancer+Institute+pilot+trial+%28CCG-1942%29.&rft.au=Jacobs%2C+Shana+S%3BStork%2C+Linda+C%3BBostrom%2C+Bruce+C%3BHutchinson%2C+Ray%3BHolcenberg%2C+John%3BReaman%2C+Gregory+H%3BErdmann%2C+Gary%3BFranklin%2C+Janet%3BNeglia%2C+Joseph+P%3BSteinberg%2C+Seth+M%3BBalis%2C+Frank+M%3BAdamson%2C+Peter+C%3BChildren%27s+Oncology+Group%3BNational+Cancer+Institute&rft.aulast=Jacobs&rft.aufirst=Shana&rft.date=2007-09-01&rft.volume=49&rft.issue=3&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=Pediatric+blood+%26+cancer&rft.issn=15455009&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-18 N1 - Date created - 2007-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Yoga therapy as an add-on treatment in the management of patients with schizophrenia--a randomized controlled trial. AN - 70750281; 17655565 AB - Treatment of schizophrenia has remained unsatisfactory despite the availability of antipsychotics. This study examined the efficacy of yoga therapy (YT) as an add-on treatment to the ongoing antipsychotic treatment. Sixty-one moderately ill schizophrenia patients were randomly assigned to YT (n = 31) and physical exercise therapy (PT; n = 30) for 4 months. They were assessed at baseline and 4 months after the start of intervention, by a rater who was blind to their group status. Forty-one subjects (YT = 21; PT = 20) were available at the end of 4 months for assessment. Subjects in the YT group had significantly less psychopathology than those in the PT group at the end of 4 months. They also had significantly greater social and occupational functioning and quality of life. Both non-pharmacological interventions contribute to reduction in symptoms, with YT having better efficacy. JF - Acta psychiatrica Scandinavica AU - Duraiswamy, G AU - Thirthalli, J AU - Nagendra, H R AU - Gangadhar, B N AD - Department of Psychiatry, National Institute of Mental Health and NeuroSciences, Bangalore 560029, India. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 226 EP - 232 VL - 116 IS - 3 SN - 0001-690X, 0001-690X KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Psychiatric Status Rating Scales KW - Depression -- therapy KW - Single-Blind Method KW - Combined Modality Therapy KW - Humans KW - Depression -- psychology KW - Adult KW - Follow-Up Studies KW - Exercise -- psychology KW - Male KW - Female KW - Yoga KW - Antipsychotic Agents -- therapeutic use KW - Schizophrenic Psychology KW - Schizophrenia -- therapy KW - Antipsychotic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70750281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+psychiatrica+Scandinavica&rft.atitle=Yoga+therapy+as+an+add-on+treatment+in+the+management+of+patients+with+schizophrenia--a+randomized+controlled+trial.&rft.au=Duraiswamy%2C+G%3BThirthalli%2C+J%3BNagendra%2C+H+R%3BGangadhar%2C+B+N&rft.aulast=Duraiswamy&rft.aufirst=G&rft.date=2007-09-01&rft.volume=116&rft.issue=3&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Acta+psychiatrica+Scandinavica&rft.issn=0001690X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-18 N1 - Date created - 2007-07-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Acta Psychiatr Scand. 2008 May;117(5):397 [18241310] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The combined activation of positive costimulatory signals with modulation of a negative costimulatory signal for the enhancement of vaccine-mediated T-cell responses. AN - 70661828; 17318654 AB - Blockade of CTLA-4 by monoclonal antibodies (mAb) can mediate regression of tumors and increase the efficacy of tumor antigen specific vaccines. Blockade of CTLA-4 has also been shown to significantly increase the avidity of antigen-specific T cells after immunization with live recombinant viral vector based vaccine. Here, we demonstrate a biological synergy between CTLA-4 blockade and active vaccine therapy consisting of recombinant vaccinia and avipox viruses expressing carcinoembryonic antigen (CEA) and three T cell costimulatory molecules to enhance antitumor effects. However, this synergy was very much dependent on the temporal relationship of scheduling of the two agents. We evaluated the strategies in both a foreign antigen model using beta-galactosidase as immunogen, and in a "self" antigen model using CEA as immunogen. For antitumor activity the model used consisted of mice transgenic for human CEA and a murine carcinoma cell line transfected with CEA. The enhanced antitumor activity after vaccine and CTLA-4 blockade did not result in any signs of autoimmunity. These studies form a rational basis for the use of vector-based vaccines with anti-CTLA-4 and demonstrate that both enhancement of positive costimulatory signals and inhibition of negative costimulatory signals can be simultaneously exploited. These studies also underscore the importance of "drug" scheduling in vaccine combination therapies. JF - Cancer immunology, immunotherapy : CII AU - Chakraborty, Mala AU - Schlom, Jeffrey AU - Hodge, James W AD - Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive Room 8B09, Bethesda, MD 20892, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 1471 EP - 1484 VL - 56 IS - 9 SN - 0340-7004, 0340-7004 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, CD KW - Antigens, Differentiation KW - CTLA-4 Antigen KW - CTLA4 protein, human KW - Cancer Vaccines KW - Ctla4 protein, mouse KW - Recombinant Proteins KW - Index Medicus KW - Animals KW - Humans KW - Mice, Inbred C57BL KW - Antigens, CD -- drug effects KW - Mice KW - Cell Line, Tumor KW - Antibody Affinity KW - Recombinant Proteins -- genetics KW - Antigens, Differentiation -- drug effects KW - Female KW - Lymphocyte Activation KW - Vaccinia virus -- genetics KW - Cancer Vaccines -- pharmacology KW - Immunization -- methods KW - Antibodies, Monoclonal -- pharmacology KW - Neoplasms -- therapy KW - Drug Synergism KW - T-Lymphocytes -- immunology KW - Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70661828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+immunology%2C+immunotherapy+%3A+CII&rft.atitle=The+combined+activation+of+positive+costimulatory+signals+with+modulation+of+a+negative+costimulatory+signal+for+the+enhancement+of+vaccine-mediated+T-cell+responses.&rft.au=Chakraborty%2C+Mala%3BSchlom%2C+Jeffrey%3BHodge%2C+James+W&rft.aulast=Chakraborty&rft.aufirst=Mala&rft.date=2007-09-01&rft.volume=56&rft.issue=9&rft.spage=1471&rft.isbn=&rft.btitle=&rft.title=Cancer+immunology%2C+immunotherapy+%3A+CII&rft.issn=03407004&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-06 N1 - Date created - 2007-06-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Obesity, metabolic syndrome, and prostate cancer. AN - 70094090; 18265478 AB - Although obesity has been consistently linked to an increased risk of several malignancies, including cancers of the colon, gallbladder, kidney, and pancreas, its role in prostate cancer etiology remains elusive. Data on the association between obesity and prostate cancer incidence are inconsistent, and in some studies obesity is associated with an increase in risk of high-grade prostate cancer but with a decrease in risk of low-grade tumors. In contrast, obesity has been consistently associated with an increased risk of prostate cancer aggressiveness and mortality. The differential effects of obesity on subtypes of prostate cancer suggest etiologic heterogeneity in these tumors and complex interactions between androgen metabolism and several putative risk factors, including insulin resistance, diabetes, inflammation, and genetic susceptibility, on prostate cancer risk. Data on the role of abdominal obesity, insulin resistance, and metabolic syndrome in prostate cancer etiology are limited. Obesity has been shown to be associated with a state of low-grade chronic inflammation, and insulin resistance and the metabolic syndrome are associated with adverse metabolic profiles and with higher circulating concentrations of inflammation-related markers, including leptin, interleukin-6, and tumor necrosis factor-, many of which have been shown to enhance tumor growth. Thus, whether obesity and metabolic syndrome modulate the risk of prostate cancer through chronic inflammation needs to be investigated further. Given that the prevalence of obesity and metabolic syndrome is increasing worldwide and that the world population is aging, the roles of obesity and metabolic syndrome in prostate carcinogenesis warrant further clarification. JF - The American journal of clinical nutrition AU - Hsing, Ann W AU - Sakoda, Lori C AU - Chua, Streamson AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852-7234, USA. hsinga@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - s843 EP - s857 VL - 86 IS - 3 SN - 0002-9165, 0002-9165 KW - Leptin KW - 0 KW - Somatomedins KW - Abridged Index Medicus KW - Index Medicus KW - Risk Factors KW - Humans KW - Somatomedins -- physiology KW - Inflammation -- metabolism KW - Body Mass Index KW - Leptin -- metabolism KW - Abdominal Fat -- metabolism KW - Somatomedins -- metabolism KW - Male KW - Inflammation -- complications KW - Prostatic Neoplasms -- etiology KW - Prostatic Neoplasms -- mortality KW - Prostatic Neoplasms -- epidemiology KW - Metabolic Syndrome X -- epidemiology KW - Obesity -- epidemiology KW - Obesity -- complications KW - Metabolic Syndrome X -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70094090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.atitle=Obesity%2C+metabolic+syndrome%2C+and+prostate+cancer.&rft.au=Hsing%2C+Ann+W%3BSakoda%2C+Lori+C%3BChua%2C+Streamson&rft.aulast=Hsing&rft.aufirst=Ann&rft.date=2007-09-01&rft.volume=86&rft.issue=3&rft.spage=s843&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+clinical+nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-07 N1 - Date created - 2008-02-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The clinical response on bone metastasis from breast and lung cancer during treatment with zoledronic acid is inversely correlated to skeletal related events (SRE). AN - 68475509; 17987788 AB - Current management of bone metastases involves a multimodal approach. Aminobisphosphonates (BPs) are a valid weapon in the treatment of skeletal localization of tumour disease. Patients with bone metastases from breast and lung cancer were enrolled in order to evaluate the impact of the addition of bisphosphonates therapy to standard treatments in terms of (i) pain control, (ii) quality of life (QoL) and (iii) toxicity and to evaluate (iv) any relations between clinical activity and the occurrence of SREs. A total of 60 patients were included in the study. Median age was 76 years (range 40-83). The majority of patients were treated with chemotherapy or hormonal therapy. All patients received zoledronic acid (ZOL) (4 mg) every 3-4 weeks for at least 3 cycles. No significant improvement in Performance Status of patients after 12 cycles of ZOL (p = 0.1672) was recorded. A statistically significant early and long-lasting amelioration of both pain, narcotic scores and QoL was found. Twenty-one patients (48%) experienced at least one SRE during the study. The most common SRE was radiation to bone (30% of patients). An inverse correlation between bone tumour response and SREs was also found (p = 0.019). ZOL addition induces a clinical benefit and improves QoL of patients with bone metastases. Moreover, the occurrence of bone clinical response is related to a reduced risk of SREs. JF - Journal of experimental & clinical cancer research : CR AU - Facchini, G AU - Caraglia, M AU - Santini, D AU - Nasti, G AU - Ottaiano, A AU - Striano, S AU - Maiolino, P AU - Ruberto, M AU - Fiore, F AU - Tonini, G AU - Budillon, A AU - Iaffaioli, R V AU - Zeppetella, G L AD - Medical Oncology Division B, National Cancer Institute, Naples, Italy. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 307 EP - 312 VL - 26 IS - 3 SN - 0392-9078, 0392-9078 KW - Bone Density Conservation Agents KW - 0 KW - Diphosphonates KW - Imidazoles KW - zoledronic acid KW - 6XC1PAD3KF KW - Index Medicus KW - Musculoskeletal System -- drug effects KW - Aged, 80 and over KW - Humans KW - Adult KW - Quality of Life KW - Aged KW - Middle Aged KW - Male KW - Female KW - Breast Neoplasms -- drug therapy KW - Diphosphonates -- therapeutic use KW - Diphosphonates -- adverse effects KW - Bone Density Conservation Agents -- therapeutic use KW - Imidazoles -- administration & dosage KW - Lung Neoplasms -- drug therapy KW - Bone Density Conservation Agents -- adverse effects KW - Breast Neoplasms -- pathology KW - Diphosphonates -- administration & dosage KW - Imidazoles -- therapeutic use KW - Bone Density Conservation Agents -- administration & dosage KW - Bone Neoplasms -- secondary KW - Imidazoles -- adverse effects KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68475509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+experimental+%26+clinical+cancer+research+%3A+CR&rft.atitle=The+clinical+response+on+bone+metastasis+from+breast+and+lung+cancer+during+treatment+with+zoledronic+acid+is+inversely+correlated+to+skeletal+related+events+%28SRE%29.&rft.au=Facchini%2C+G%3BCaraglia%2C+M%3BSantini%2C+D%3BNasti%2C+G%3BOttaiano%2C+A%3BStriano%2C+S%3BMaiolino%2C+P%3BRuberto%2C+M%3BFiore%2C+F%3BTonini%2C+G%3BBudillon%2C+A%3BIaffaioli%2C+R+V%3BZeppetella%2C+G+L&rft.aulast=Facchini&rft.aufirst=G&rft.date=2007-09-01&rft.volume=26&rft.issue=3&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Journal+of+experimental+%26+clinical+cancer+research+%3A+CR&rft.issn=03929078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-26 N1 - Date created - 2007-11-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - DLC-1:a Rho GTPase-activating protein and tumour suppressor. AN - 68470991; 17979893 AB - The deleted in liver cancer 1 (DLC-1) gene encodes a GTPase activating protein that acts as a negative regulator of the Rho family of small GTPases. Rho proteins transduce signals that influence cell morphology and physiology, and their aberrant up-regulation is a key factor in the neoplastic process, including metastasis. Since its discovery, compelling evidence has accumulated that demonstrates a role for DLC-1 as a bona fide tumour suppressor gene in different types of human cancer. Loss of DLC-1 expression mediated by genetic and epigenetic mechanisms has been associated with the development of many human cancers, and restoration of DLC-1 expression inhibited the growth of tumour cells in vivo and in vitro. Two closely related genes, DLC-2 and DLC-3, may also be tumour suppressors. This review presents the current status of progress in understanding the biological functions of DLC-1 and its relatives and their roles in neoplasia. JF - Journal of cellular and molecular medicine AU - Durkin, Marian E AU - Yuan, Bao-Zhu AU - Zhou, Xiaoling AU - Zimonjic, Drazen B AU - Lowy, Douglas R AU - Thorgeirsson, Snorri S AU - Popescu, Nicholas C AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. PY - 2007 SP - 1185 EP - 1207 VL - 11 IS - 5 SN - 1582-1838, 1582-1838 KW - GTPase-Activating Proteins KW - 0 KW - Tumor Suppressor Proteins KW - rho GTPase-activating protein KW - Index Medicus KW - Animals KW - Neoplasms -- pathology KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Protein Structure, Tertiary KW - Neoplasms -- metabolism KW - GTPase-Activating Proteins -- genetics KW - GTPase-Activating Proteins -- chemistry KW - GTPase-Activating Proteins -- metabolism KW - Tumor Suppressor Proteins -- metabolism KW - Tumor Suppressor Proteins -- genetics KW - Tumor Suppressor Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68470991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+and+molecular+medicine&rft.atitle=DLC-1%3Aa+Rho+GTPase-activating+protein+and+tumour+suppressor.&rft.au=Durkin%2C+Marian+E%3BYuan%2C+Bao-Zhu%3BZhou%2C+Xiaoling%3BZimonjic%2C+Drazen+B%3BLowy%2C+Douglas+R%3BThorgeirsson%2C+Snorri+S%3BPopescu%2C+Nicholas+C&rft.aulast=Durkin&rft.aufirst=Marian&rft.date=2007-09-01&rft.volume=11&rft.issue=5&rft.spage=1185&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+and+molecular+medicine&rft.issn=15821838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-04 N1 - Date created - 2007-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Structure and function of the human calcium-sensing receptor: insights from natural and engineered mutations and allosteric modulators. AN - 68470169; 17979873 AB - The human extracellular Ca(2+)-sensing receptor (CaR), a member of the G protein-coupled receptor family 3, plays a key role in the regulation of extracellular calcium homeostasis. It is one of just a few G protein-coupled receptors with a large number of naturally occurring mutations identified in patients. In contrast to the small sizes of its agonists, this large dimeric receptor consists of domains with topologically distinctive orthosteric and allosteric sites. Information derived from studies of naturally occurring mutations, engineered mutations, allosteric modulators and crystal structures of the agonist-binding domain of homologous type 1 metabotropic glutamate receptor and G protein-coupled rhodopsin offers new insights into the structure and function of the CaR. JF - Journal of cellular and molecular medicine AU - Hu, Jianxin AU - Spiegel, Allen M AD - Molecular Signalling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. jianxinh@niddk.nih.gov PY - 2007 SP - 908 EP - 922 VL - 11 IS - 5 SN - 1582-1838, 1582-1838 KW - Receptors, Calcium-Sensing KW - 0 KW - Index Medicus KW - Hyperparathyroidism -- metabolism KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Allosteric Regulation KW - Structure-Activity Relationship KW - Receptors, Calcium-Sensing -- chemistry KW - Receptors, Calcium-Sensing -- metabolism KW - Mutation -- genetics KW - Mutagenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68470169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+and+molecular+medicine&rft.atitle=Structure+and+function+of+the+human+calcium-sensing+receptor%3A+insights+from+natural+and+engineered+mutations+and+allosteric+modulators.&rft.au=Hu%2C+Jianxin%3BSpiegel%2C+Allen+M&rft.aulast=Hu&rft.aufirst=Jianxin&rft.date=2007-09-01&rft.volume=11&rft.issue=5&rft.spage=908&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+and+molecular+medicine&rft.issn=15821838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-04 N1 - Date created - 2007-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phase II trial of neoadjuvant gemcitabine and cisplatin in patients with resectable bladder carcinoma. AN - 68466991; 17980060 AB - Gemcitabine and cisplatin (GC) is an active combination in the treatment of metastatic bladder cancer. We have prospectively analyzed the efficacy and tolerability of GC as neoadjuvant treatment of invasive bladder cancer. In this single-institution phase II trial, patients with muscle-invasive transitional cell carcinoma received three cycles of gemcitabine 1200 mg/m2 on days 1 and 8 with cisplatin 75 mg/m2 on day 1 prior to surgery. Radiologic response was evaluated by computed tomography and magnetic resonance imaging. All patients were referred to surgery after chemotherapy completion. Between June 2002 and March 2005, 22 patients (19 males) were enrolled. Median age was 63 years. Initial stage was II (T2) in 11 and III (T3-4) in 11 patients. Median follow-up is 26 months (4-43). Partial or complete radiologic response rate was documented in 13 out of 20 assessable patients (70%). One patient was excluded due to sarcomatoid carcinoma at definitive pathologic examination. Cystectomy was performed in 15 patients and pelvic radiotherapy in four patients. Nine out of 21 patients (43%) relapsed and four (19%) died due to disease progression. Complete pathologic response was observed in four patients (26.7% of 15). Median progression-free survival was 27 months (CI 95% not reached) with median overall survival of 36 months (CI 95%: 28.7 - 43.3). Grade III/IV toxicity was infrequent, with no deaths due to chemotherapy. The combination of GC is effective and well-tolerated when used as neoadjuvant therapy in muscle-invasive bladder cancer. Longer follow-up is necessary to evaluate its impact on the overall survival of these patients. JF - International braz j urol : official journal of the Brazilian Society of Urology AU - Herchenhorn, Daniel AU - Dienstmann, Rodrigo AU - Peixoto, Fabio A AU - de Campos, Franz S AU - Santos, Valdelice O AU - Moreira, Denise M AU - Cardoso, Hedilene AU - Small, Isabele A AU - Ferreira, Carlos G AD - Department of Clinical Oncology, National Cancer Institute, Rio de Janeiro, RJ, Brazil. PY - 2007 SP - 630 EP - 8; discussion 638 VL - 33 IS - 5 SN - 1677-5538, 1677-5538 KW - Deoxycytidine KW - 0W860991D6 KW - gemcitabine KW - B76N6SBZ8R KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Disease-Free Survival KW - Deoxycytidine -- analogs & derivatives KW - Humans KW - Aged KW - Cisplatin -- administration & dosage KW - Prospective Studies KW - Adult KW - Treatment Outcome KW - Deoxycytidine -- administration & dosage KW - Middle Aged KW - Follow-Up Studies KW - Adolescent KW - Chemotherapy, Adjuvant KW - Female KW - Male KW - Carcinoma, Transitional Cell -- surgery KW - Urinary Bladder Neoplasms -- surgery KW - Urinary Bladder Neoplasms -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Carcinoma, Transitional Cell -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68466991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+braz+j+urol+%3A+official+journal+of+the+Brazilian+Society+of+Urology&rft.atitle=Phase+II+trial+of+neoadjuvant+gemcitabine+and+cisplatin+in+patients+with+resectable+bladder+carcinoma.&rft.au=Herchenhorn%2C+Daniel%3BDienstmann%2C+Rodrigo%3BPeixoto%2C+Fabio+A%3Bde+Campos%2C+Franz+S%3BSantos%2C+Valdelice+O%3BMoreira%2C+Denise+M%3BCardoso%2C+Hedilene%3BSmall%2C+Isabele+A%3BFerreira%2C+Carlos+G&rft.aulast=Herchenhorn&rft.aufirst=Daniel&rft.date=2007-09-01&rft.volume=33&rft.issue=5&rft.spage=630&rft.isbn=&rft.btitle=&rft.title=International+braz+j+urol+%3A+official+journal+of+the+Brazilian+Society+of+Urology&rft.issn=16775538&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-24 N1 - Date created - 2007-11-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Int Braz J Urol. 2007 Nov-Dec;33(6):840-1 [18199355] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Persistent hypocalcemia induced by zoledronic acid in a patient with androgen-independent prostate cancer and extensive bone metastases. AN - 68427570; 17956715 AB - Zoledronic acid is a highly potent bisphosphonate that has been shown to reduce skeletal-related events in patients with androgen-independent prostate cancer metastatic to bone. We report a patient with androgen-independent prostate cancer and extensive bone metastases. After receiving a single dose of zoledronic acid, the patient developed hypocalcemia that persisted for approximately 60 days despite intravenous and oral calcium supplementation, likely because of excess unopposed osteoblastic activity. This case underscores the need for calcium and vitamin D monitoring and supplementation to avoid bisphosphonate-induced secondary hyperparathyroidism and highlights the possibility that extensive osteoblastic metastasis alone might lead to hypocalcemia. JF - Clinical genitourinary cancer AU - Gulley, James L AU - Wu, Shenhong AU - Arlen, Philip M AU - Dahut, William L AD - Medical Oncology Branch, Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. gulleyj@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 403 EP - 405 VL - 5 IS - 6 SN - 1558-7673, 1558-7673 KW - Bone Density Conservation Agents KW - 0 KW - Diphosphonates KW - Imidazoles KW - zoledronic acid KW - 6XC1PAD3KF KW - Index Medicus KW - Bone Resorption -- prevention & control KW - Humans KW - Middle Aged KW - Male KW - Diphosphonates -- adverse effects KW - Imidazoles -- administration & dosage KW - Neoplasms, Hormone-Dependent -- drug therapy KW - Neoplasms, Hormone-Dependent -- pathology KW - Prostatic Neoplasms -- drug therapy KW - Hypocalcemia -- chemically induced KW - Bone Density Conservation Agents -- adverse effects KW - Prostatic Neoplasms -- pathology KW - Diphosphonates -- administration & dosage KW - Bone Neoplasms -- drug therapy KW - Adenocarcinoma -- secondary KW - Adenocarcinoma -- drug therapy KW - Bone Density Conservation Agents -- administration & dosage KW - Bone Neoplasms -- secondary KW - Imidazoles -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68427570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+genitourinary+cancer&rft.atitle=Persistent+hypocalcemia+induced+by+zoledronic+acid+in+a+patient+with+androgen-independent+prostate+cancer+and+extensive+bone+metastases.&rft.au=Gulley%2C+James+L%3BWu%2C+Shenhong%3BArlen%2C+Philip+M%3BDahut%2C+William+L&rft.aulast=Gulley&rft.aufirst=James&rft.date=2007-09-01&rft.volume=5&rft.issue=6&rft.spage=403&rft.isbn=&rft.btitle=&rft.title=Clinical+genitourinary+cancer&rft.issn=15587673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-03 N1 - Date created - 2007-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A second transient prostate-specific antigen elevation after external-beam radiation therapy and fractionated magnetic resonance imaging-guided high-dose rate brachytherapy boost. AN - 68426389; 17956716 AB - A 63-year-old man with a T1c adenocarcinoma of the prostate, Gleason score of 7 (4+3), and a pretreatment prostate-specific antigen (PSA) level of 9.5 ng/mL was treated with external-beam radiation therapy (45 Gy) and 2 magnetic resonance imaging-guided high-dose rate brachytherapy boosts (10 Gy each.) The patient also received neoadjuvant, concurrent, and adjuvant hormonal treatment with leuprolide for 7 months total. Without any further intervention the patient had 2 separate and prolonged PSA increases and decreases 12-35 months after therapy. His PSA nadir was <0.2 ng/mL and rose slowly over several months to 4.2 ng/mL, resolved, and then rose 2.3 ng/mL before again slowly resolving. After prostate irradiation, many patients experience a transient rise in serum PSA levels and a subsequent decline without any treatment. This is known as a PSA "bounce" or "bump." Some patients experience a second transient rise in PSA levels after irradiation. To our knowledge, this case report is the first documentation of a second PSA bump in a patient treated with external-beam radiation therapy and high-dose rate boost therapy and provides context to address concerns and therapeutic decisions confronting physicians and patients. JF - Clinical genitourinary cancer AU - Mishra, Mark V AU - Singh, Anurag K AD - Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 406 EP - 408 VL - 5 IS - 6 SN - 1558-7673, 1558-7673 KW - Antineoplastic Agents, Hormonal KW - 0 KW - Prostate-Specific Antigen KW - EC 3.4.21.77 KW - Leuprolide KW - EFY6W0M8TG KW - Index Medicus KW - Radiotherapy Dosage KW - Humans KW - Treatment Outcome KW - Middle Aged KW - Follow-Up Studies KW - Antineoplastic Agents, Hormonal -- therapeutic use KW - Male KW - Magnetic Resonance Imaging KW - Adenocarcinoma -- blood KW - Radiotherapy, Conformal KW - Brachytherapy -- adverse effects KW - Prostatic Neoplasms -- blood KW - Prostate-Specific Antigen -- blood KW - Prostatic Neoplasms -- drug therapy KW - Adenocarcinoma -- drug therapy KW - Prostatic Neoplasms -- radiotherapy KW - Adenocarcinoma -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68426389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+genitourinary+cancer&rft.atitle=A+second+transient+prostate-specific+antigen+elevation+after+external-beam+radiation+therapy+and+fractionated+magnetic+resonance+imaging-guided+high-dose+rate+brachytherapy+boost.&rft.au=Mishra%2C+Mark+V%3BSingh%2C+Anurag+K&rft.aulast=Mishra&rft.aufirst=Mark&rft.date=2007-09-01&rft.volume=5&rft.issue=6&rft.spage=406&rft.isbn=&rft.btitle=&rft.title=Clinical+genitourinary+cancer&rft.issn=15587673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-03 N1 - Date created - 2007-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Thymosin alpha1 as a chemopreventive agent in lung and breast cancer. AN - 68406532; 17567944 AB - The ability of thymosin alpha1 (Talpha1) to prevent lung and breast cancer was investigated. Lung adenomas developed in A/J mice injected with carcinogens, such as urethane. The lung adenoma number was reduced by 15-45% if animals were daily treated subcutaneously (s.c.) with Talpha1 (0.4 mg/kg). Talpha1 (1 microM) directly inhibited the growth of mouse lung cell lines. These results suggest that Talpha1 may prevent mouse lung carcinogenesis because it directly inhibits the growth of lung cancer cells. Talpha1 prevented mammary carcinogenesis in two animal models. In the Fisher rat, an animal model of mammary cancer that is estrogen receptor dependent, tumors were initiated by the injection of N-methylurea (NMU). The rat survival was significantly increased by the daily injection of Talpha1. In the SV40T antigen mouse, a transgenic female mouse that spontaneously gets mammary cancer in an estrogen receptor-independent manner, survival was increased and tumor burden was significantly decreased by daily injection of Talpha1. These results indicate that Talpha1 is a chemopreventive agent in animal models for lung and breast carcinogenesis. JF - Annals of the New York Academy of Sciences AU - Moody, Terry W AD - Department of Health and Human Services, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. moodyt@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 297 EP - 304 VL - 1112 SN - 0077-8923, 0077-8923 KW - Anticarcinogenic Agents KW - 0 KW - Thymosin KW - 61512-21-8 KW - thymalfasin KW - W0B22ISQ1C KW - Index Medicus KW - Rats KW - Mice, Inbred A KW - Animals KW - Rats, Inbred F344 KW - Adenoma -- prevention & control KW - Mice KW - Female KW - Lung Neoplasms -- prevention & control KW - Anticarcinogenic Agents -- therapeutic use KW - Thymosin -- therapeutic use KW - Mammary Neoplasms, Animal -- prevention & control KW - Thymosin -- analogs & derivatives KW - Mammary Neoplasms, Animal -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68406532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Thymosin+alpha1+as+a+chemopreventive+agent+in+lung+and+breast+cancer.&rft.au=Moody%2C+Terry+W&rft.aulast=Moody&rft.aufirst=Terry&rft.date=2007-09-01&rft.volume=1112&rft.issue=&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-27 N1 - Date created - 2007-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A fold-back single-chain diabody format enhances the bioactivity of an anti-monkey CD3 recombinant diphtheria toxin-based immunotoxin. AN - 68373271; 17693455 AB - T-cell depleting anti-CD3 immunotoxins have utility in non-human primate models of transplantation tolerance and autoimmune disease therapy. We recently reported that an affinity matured single-chain (scFv) anti-monkey CD3 antibody, C207, had increased binding to T-cells and increased bioactivity in a diphtheria toxin (DT)-based biscFv immunotoxin compared with the parental antibody, FN18. However, FN18 scFvs and their mutant derivatives such as C207 did not exhibit robust bivalent character in the biscFv format. We now report that C207 in a diabody format exhibits a 7-fold increase in binding to T-cells over scFv (C207) indicating considerable divalent character for the diabody. This construct was formed by reducing the V(L)/V(H) linker to five residues and was secreted from Pichia pastoris as the non-covalent dimer. An immunotoxin based on this diabody format was secreted as a non-covalent dimer but was devoid of bioactivity and failed to bind T-cells, suggesting steric hindrance from the two large closely positioned truncated DT moieties. We constructed a single-chain diabody immunotoxin by fusing to the truncated DT C-terminus L1-VL-L1-VH-L2-VL-L1-VH where L1 is a five-residue linker and L2 is the longer (G4S)3 linker permitting interactions between the distal and proximal VL/VH domains. This 'fold-back' immunotoxin was secreted predominantly as the monomer and exhibited a 5- to 7-fold increase in bioactivity over DT390biscFv(C207) and depleted monkey T-cells in vivo. JF - Protein engineering, design & selection : PEDS AU - Kim, Geun-Bae AU - Wang, Zhirui AU - Liu, Yuan Yi AU - Stavrou, Scott AU - Mathias, Askale AU - Goodwin, K Jeanine AU - Thomas, Judith M AU - Neville, David M AD - Section on Biophysical Chemistry, Laboratory of Molecular Biology, National Institute of Mental Health, Bldg 10, Room 3D46, 10 Center Drive, Bethesda, MD 20892-1216, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 425 EP - 432 VL - 20 IS - 9 SN - 1741-0126, 1741-0126 KW - Antigens, CD3 KW - 0 KW - Diphtheria Toxin KW - Immunoglobulin Fragments KW - Immunotoxins KW - Recombinant Fusion Proteins KW - Index Medicus KW - Animals KW - T-Lymphocytes -- metabolism KW - Plasmids -- metabolism KW - Dimerization KW - Pichia -- metabolism KW - Time Factors KW - Haplorhini KW - Recombinant Fusion Proteins -- chemistry KW - Immunoglobulin Fragments -- chemistry KW - Immunotoxins -- chemistry KW - Antigens, CD3 -- chemistry KW - Diphtheria Toxin -- chemistry KW - Protein Engineering -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68373271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+engineering%2C+design+%26+selection+%3A+PEDS&rft.atitle=A+fold-back+single-chain+diabody+format+enhances+the+bioactivity+of+an+anti-monkey+CD3+recombinant+diphtheria+toxin-based+immunotoxin.&rft.au=Kim%2C+Geun-Bae%3BWang%2C+Zhirui%3BLiu%2C+Yuan+Yi%3BStavrou%2C+Scott%3BMathias%2C+Askale%3BGoodwin%2C+K+Jeanine%3BThomas%2C+Judith+M%3BNeville%2C+David+M&rft.aulast=Kim&rft.aufirst=Geun-Bae&rft.date=2007-09-01&rft.volume=20&rft.issue=9&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Protein+engineering%2C+design+%26+selection+%3A+PEDS&rft.issn=17410126&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-13 N1 - Date created - 2007-10-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets. AN - 68332364; 17908040 AB - As the average ages of North Americans and Europeans continue to rise; similarly the incidence of "old age" associated illnesses likewise increases. Most notably among these ailments are conditions linked to dementia-related neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD) and stroke. While in the early stages, these conditions are associated with cellular dysfunction in distinctly different brain regions, thus affecting different neuronal cell types; it is most likely that the final stages share similar cellular and molecular processes leading to neuronal death and ultimately overt clinical symptoms. In this regard, different environmental and genetic triggers ranging from head trauma to protein mutations and toxicological exposure may instigate a cascade of intracellular events that ultimately lead to neuronal death. One strong candidate trigger protein, and thus a potential target for therapeutic manipulation is the potent pro-inflammatory / pro-apoptotic cytokine, tumor necrosis factor-alpha (TNF-alpha). TNF-alpha is secreted by the brain resident marcophage (the microglial cell) in response to various stimuli. It has been demonstrated to play a major role in central nervous system (CNS) neuroinflammation-mediated cell death in AD, PD and amyotrophic lateral sclerosis (ALS) as well as several other CNS complications. Recently, agents that modulate the levels of circulating peripheral TNF-alpha protein have been shown to be worthwhile therapeutic agents with the use of Enbrel (Etanercept) and Remicade (Infliximab), both of which display beneficial properties against rheumatoid arthritis and other peripheral inflammatory diseases. Unfortunately, these agents are largely unable to penetrate the blood-brain barrier, which severely limits their use in the setting of neuroinflammation in the CNS. However, thalidomide, a small molecule drug, can inhibit TNF-alpha protein synthesis and, unlike larger molecules, is readily capable of crossing the blood-brain barrier. Thus thalidomide and its analogs are excellent candidate agents for use in determining the potential value of anti-TNF-alpha therapies in a variety of diseases underpinned by inflammation within the nervous system. Consequently, we have chosen to discuss the relevance of unregulated TNF-alpha expression in illnesses of the CNS and, to an extent, the peripheral nervous system. Additionally, we consider the utilization of thalidomide-derived agents as anti-TNF-alpha therapeutics in the setting of neuroinflammation. JF - Current Alzheimer research AU - Tweedie, David AU - Sambamurti, Kumar AU - Greig, Nigel H AD - Drug Design & Development Section, Laboratory of Neurosciences, Intramural Research Program, NIA, NIH, Baltimore, MD 21224, USA. Tweedieda@grc.nia.nih.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 378 EP - 385 VL - 4 IS - 4 SN - 1567-2050, 1567-2050 KW - Enzyme Inhibitors KW - 0 KW - Tumor Necrosis Factor-alpha KW - Index Medicus KW - Animals KW - Humans KW - Neurodegenerative Diseases -- drug therapy KW - Enzyme Inhibitors -- therapeutic use KW - Tumor Necrosis Factor-alpha -- physiology KW - Tumor Necrosis Factor-alpha -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68332364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Alzheimer+research&rft.atitle=TNF-alpha+inhibition+as+a+treatment+strategy+for+neurodegenerative+disorders%3A+new+drug+candidates+and+targets.&rft.au=Tweedie%2C+David%3BSambamurti%2C+Kumar%3BGreig%2C+Nigel+H&rft.aulast=Tweedie&rft.aufirst=David&rft.date=2007-09-01&rft.volume=4&rft.issue=4&rft.spage=378&rft.isbn=&rft.btitle=&rft.title=Current+Alzheimer+research&rft.issn=15672050&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-01 N1 - Date created - 2007-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in the Central and Eastern European Kidney Cancer Study. AN - 68327410; 17617661 AB - High consumption of cruciferous vegetables has been associated with reduced kidney cancer risk in many studies. Isothiocyanates, thought to be responsible for the chemopreventive properties of this food group, are conjugated to glutathione by glutathione S-transferases (GSTs) before urinary excretion. Modification of this relationship by host genetic factors is unknown. We investigated cruciferous vegetable intake in 1097 cases and 1555 controls enrolled in a multicentric case-control study from the Czech Republic, Poland, Romania and Russia. To assess possible gene-diet interactions, genotyped cases (N = 925) and controls (N = 1247) for selected functional or non-synonymous polymorphisms including the GSTM1 deletion, GSTM3 3 bp deletion (IVS6 + 22-AGG) and V224I G>A substitution, GSTT1 deletion and the GSTP1 I105V A>G substitution. The odds ratio (OR) for low (less than once per month) versus high (at least once per week) intake of cruciferous vegetables was 1.29 [95% confidence interval (CI): 1.02-1.62; P-trend = 0.03]. When low intake of cruciferous vegetables (less than once per month) was stratified by GST genotype, higher kidney cancer risks were observed among individuals with the GSTT1 null (OR = 1.86; 95% CI: 1.07-3.23; P-interaction = 0.05) or with both GSTM1/T1 null genotypes (OR = 2.49; 95% CI: 1.08-5.77; P-interaction = 0.05). These data provide additional evidence for the role of cruciferous vegetables in cancer prevention among individuals with common, functional genetic polymorphisms. JF - Carcinogenesis AU - Moore, L E AU - Brennan, P AU - Karami, S AU - Hung, R J AU - Hsu, C AU - Boffetta, P AU - Toro, J AU - Zaridze, D AU - Janout, V AU - Bencko, V AU - Navratilova, M AU - Szeszenia-Dabrowska, N AU - Mates, D AU - Mukeria, A AU - Holcatova, I AU - Welch, R AU - Chanock, S AU - Rothman, N AU - Chow, W-H AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. moorele@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 1960 EP - 1964 VL - 28 IS - 9 SN - 0143-3334, 0143-3334 KW - DNA KW - 9007-49-2 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Humans KW - Aged KW - Europe -- epidemiology KW - Feeding Behavior KW - Genotype KW - DNA -- isolation & purification KW - Europe, Eastern -- epidemiology KW - Risk Factors KW - DNA -- blood KW - Adult KW - DNA -- genetics KW - Interviews as Topic KW - Middle Aged KW - Male KW - Female KW - Sequence Deletion KW - Kidney Neoplasms -- genetics KW - Vegetables KW - Brassicaceae KW - Polymorphism, Genetic KW - Kidney Neoplasms -- epidemiology KW - Glutathione Transferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68327410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Glutathione+S-transferase+polymorphisms%2C+cruciferous+vegetable+intake+and+cancer+risk+in+the+Central+and+Eastern+European+Kidney+Cancer+Study.&rft.au=Moore%2C+L+E%3BBrennan%2C+P%3BKarami%2C+S%3BHung%2C+R+J%3BHsu%2C+C%3BBoffetta%2C+P%3BToro%2C+J%3BZaridze%2C+D%3BJanout%2C+V%3BBencko%2C+V%3BNavratilova%2C+M%3BSzeszenia-Dabrowska%2C+N%3BMates%2C+D%3BMukeria%2C+A%3BHolcatova%2C+I%3BWelch%2C+R%3BChanock%2C+S%3BRothman%2C+N%3BChow%2C+W-H&rft.aulast=Moore&rft.aufirst=L&rft.date=2007-09-01&rft.volume=28&rft.issue=9&rft.spage=1960&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-14 N1 - Date created - 2007-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transforming growth factor beta 1 (TGFB1) gene polymorphisms and risk of advanced colorectal adenoma. AN - 68327365; 17615257 AB - Transforming growth factor beta 1 (TGFB1) is a multifunctional cytokine that has been implicated in the pathogenesis of colorectal neoplasia. To investigate the association between genetic variants in TGFB1 and the risk of colorectal adenoma, we conducted a case-control study of 754 advanced adenoma cases and 769 controls from the baseline screening exam of the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Cases included participants diagnosed with advanced left-sided adenoma (>or=1 cm, high-grade dysplasia or villous characteristics), and controls were subjects without evidence of a left-sided polyp by sigmoidoscopy. DNA was extracted from blood specimens, and five single-nucleotide polymorphisms in TGFB1 of known or suggested functional significance (-800G>A, -509C>T, Leu10Pro, Arg25Pro and Thr263Ile) were genotyped. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) for the association between each polymorphism and adenoma. The high TGFB1 producer genotypes, -509TT and 10Pro/Pro, were associated with an increased risk of colorectal adenoma compared with other genotypes (OR = 1.51, 95% CI: 1.04-2.20 and OR = 1.37, 95% CI: 1.02-1.86, respectively). These increased risks, particularly for -509TT, were greater for persons with multiple adenomas (OR = 1.89, 95% CI: 1.16-3.09, P = 0.01) and individuals with rectal adenoma (OR = 2.95, 95% CI: 1.66-5.26, P = 0.0002). Haplotype analysis revealed similar findings under a recessive model. No associations were observed for polymorphisms at codons 25 and 263. In conclusion, variants that enhance TGFB1 production may be associated with an increased risk of advanced colorectal adenoma. JF - Carcinogenesis AU - Berndt, Sonja I AU - Huang, Wen-Yi AU - Chatterjee, Nilanjan AU - Yeager, Meredith AU - Welch, Robert AU - Chanock, Stephen J AU - Weissfeld, Joel L AU - Schoen, Robert E AU - Hayes, Richard B AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. berndts@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 1965 EP - 1970 VL - 28 IS - 9 SN - 0143-3334, 0143-3334 KW - TGFB1 protein, human KW - 0 KW - Transforming Growth Factor beta1 KW - Index Medicus KW - Genetic Variation KW - Reference Values KW - Neoplasm Staging KW - Humans KW - Aged KW - Gene Expression Regulation, Neoplastic KW - Genotype KW - Incidence KW - Middle Aged KW - Adenoma -- genetics KW - United States -- epidemiology KW - Female KW - Male KW - Polymorphism, Genetic KW - Colorectal Neoplasms -- pathology KW - Transforming Growth Factor beta1 -- genetics KW - Colorectal Neoplasms -- genetics KW - Colorectal Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68327365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Transforming+growth+factor+beta+1+%28TGFB1%29+gene+polymorphisms+and+risk+of+advanced+colorectal+adenoma.&rft.au=Berndt%2C+Sonja+I%3BHuang%2C+Wen-Yi%3BChatterjee%2C+Nilanjan%3BYeager%2C+Meredith%3BWelch%2C+Robert%3BChanock%2C+Stephen+J%3BWeissfeld%2C+Joel+L%3BSchoen%2C+Robert+E%3BHayes%2C+Richard+B&rft.aulast=Berndt&rft.aufirst=Sonja&rft.date=2007-09-01&rft.volume=28&rft.issue=9&rft.spage=1965&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-14 N1 - Date created - 2007-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Preventive effect of diabegon, a polyherbal preparation, during progression of diabetes induced by high-fructose feeding in rats. AN - 68313590; 17878707 AB - In the present study, the polyherbal preparation diabegon, containing 18 plant extracts with hypoglycemic activity, was evaluated for its preventive effect during progression of type 2 diabetes in high-fructose-diet-fed rats. Oral administration of diabegon (100 mg/kg body weight) delayed development of glucose intolerance for 4 weeks in comparison with the diabetic control group, and the effect of diabegon was compared to that of the standard insulin sensitizer drug rosiglitazone. Diabegon treatment also ameliorated the elevation of glycosylated haemoglobin, liver glycogen content, plasma insulin, homeostasis model assessment, free fatty acids, triglycerides, total cholesterol, LDL-cholesterol, and VLDL-cholesterol, whereas it increased HDL-cholesterol after 56 days of treatment (P<0.05). The mechanism of action by which diabegon attenuates insulin resistance and dyslipidemia may be through induction of peroxisome proliferator-activated receptor-gamma and lipoprotein lipase activity in peripheral tissues (muscles). Moreover, diabegon administration for 56 days also produced no alteration in liver and kidney function tests, which seems to indicate its non-toxicity during treatment. Our present results suggest that diabegon may be included in diabetes mellitus treatment regimens, as a drug with good antidiabetic actions but no toxic manifestations. JF - Journal of pharmacological sciences AU - Yadav, Hariom AU - Jain, Shalini AU - Prasad, G B K S AU - Yadav, Mukesh AD - School of Studies in Biochemistry, Jiwaji University, Gwalior-474011, Madhya Prakesh, India. yadavh@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 12 EP - 21 VL - 105 IS - 1 SN - 1347-8613, 1347-8613 KW - Blood Glucose KW - 0 KW - Hemoglobin A, Glycosylated KW - Hypoglycemic Agents KW - Insulin KW - Lipids KW - PPAR gamma KW - Plant Extracts KW - diabegon KW - glucosylated hemoglobin A KW - Fructose KW - 30237-26-4 KW - Glycogen KW - 9005-79-2 KW - Lipoprotein Lipase KW - EC 3.1.1.34 KW - Index Medicus KW - Lipids -- blood KW - Administration, Oral KW - Animals KW - Glucose Tolerance Test KW - Blood Glucose -- metabolism KW - Hyperglycemia -- prevention & control KW - Insulin -- blood KW - Kidney -- drug effects KW - Liver -- metabolism KW - Hemoglobin A, Glycosylated -- analogs & derivatives KW - Homeostasis -- drug effects KW - Rats KW - Liver -- physiopathology KW - Glycogen -- metabolism KW - Liver -- drug effects KW - Lipoprotein Lipase -- metabolism KW - Hemoglobin A, Glycosylated -- metabolism KW - Rats, Wistar KW - PPAR gamma -- metabolism KW - Insulin Resistance KW - Male KW - Kidney -- physiopathology KW - Hyperglycemia -- blood KW - Plant Extracts -- pharmacology KW - Hypoglycemic Agents -- therapeutic use KW - Fructose -- toxicity KW - Plant Extracts -- therapeutic use KW - Hypoglycemic Agents -- administration & dosage KW - Diabetes Mellitus, Experimental -- prevention & control KW - Fructose -- administration & dosage KW - Diabetes Mellitus, Experimental -- chemically induced KW - Diabetes Mellitus, Experimental -- blood KW - Hypoglycemic Agents -- pharmacology KW - Plant Extracts -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68313590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pharmacological+sciences&rft.atitle=Preventive+effect+of+diabegon%2C+a+polyherbal+preparation%2C+during+progression+of+diabetes+induced+by+high-fructose+feeding+in+rats.&rft.au=Yadav%2C+Hariom%3BJain%2C+Shalini%3BPrasad%2C+G+B+K+S%3BYadav%2C+Mukesh&rft.aulast=Yadav&rft.aufirst=Hariom&rft.date=2007-09-01&rft.volume=105&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Journal+of+pharmacological+sciences&rft.issn=13478613&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-20 N1 - Date created - 2007-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A genetic screen for DNA double-strand break repair mutations in Drosophila. AN - 68304761; 17660539 AB - The study of DNA double-strand break (DSB) repair has been greatly facilitated by the use of rare-cutting endonucleases, which induce a break precisely at their cut sites that can be strategically placed in the genome. We previously established such a system in Drosophila and showed that the yeast I-SceI enzyme cuts efficiently in Drosophila cells and those breaks are effectively repaired by conserved mechanisms. In this study, we determined the genetic requirements for the repair of this I-SceI-induced DSB in the germline. We show that Drosophila Rad51 and Rad54 are both required for homologous repair by gene conversion, but are dispensable for single-strand annealing repair. We provided evidence suggesting that Rad51 is more stringently required than Rad54 for intersister gene conversion. We uncovered a significant role of DNA ligase IV in nonhomologous end joining. We conducted a screen for candidate mutations affecting DSB repair and discovered novel mutations in genes that include mutagen sensitive 206, single-strand annealing reducer, and others. In addition, we demonstrated an intricate balance among different repair pathways in which the cell differentially utilizes repair mechanisms in response to both changes in the genomic environment surrounding the break and deficiencies in one or the other repair pathways. JF - Genetics AU - Wei, Debbie S AU - Rong, Yikang S AD - Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 63 EP - 77 VL - 177 IS - 1 SN - 0016-6731, 0016-6731 KW - DNA, Cruciform KW - 0 KW - DNA-Binding Proteins KW - DNL4 protein, S cerevisiae KW - Drosophila Proteins KW - Egg Proteins KW - Saccharomyces cerevisiae Proteins KW - SCEI protein, S cerevisiae KW - EC 3.1.21.- KW - Deoxyribonucleases, Type II Site-Specific KW - EC 3.1.21.4 KW - okra protein, Drosophila KW - EC 3.6.1.3 KW - DNA Helicases KW - EC 3.6.4.- KW - DNA Ligases KW - EC 6.5.1.- KW - DNA Ligase ATP KW - EC 6.5.1.1 KW - Index Medicus KW - Animals KW - Egg Proteins -- genetics KW - DNA-Binding Proteins -- genetics KW - Animals, Genetically Modified KW - Deoxyribonucleases, Type II Site-Specific -- metabolism KW - Egg Proteins -- metabolism KW - Crosses, Genetic KW - Drosophila Proteins -- genetics KW - DNA Ligases -- metabolism KW - DNA, Cruciform -- physiology KW - Drosophila Proteins -- metabolism KW - Male KW - Female KW - DNA-Binding Proteins -- metabolism KW - DNA Repair -- physiology KW - Drosophila melanogaster -- genetics KW - Signal Transduction -- genetics KW - DNA Breaks, Double-Stranded UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68304761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+and+Medicine&rft.atitle=How+do+patients+evaluate+and+make+use+of+online+health+information%3F&rft.au=Sillence%2C+E%3BBriggs%2C+P%3BHarris%2C+PR%3BFishwick%2C+L&rft.aulast=Sillence&rft.aufirst=E&rft.date=2007-05-01&rft.volume=64&rft.issue=9&rft.spage=1853&rft.isbn=&rft.btitle=&rft.title=Social+Science+and+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2007.01.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-18 N1 - Date created - 2007-09-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell. 1999 Oct;4(4):511-8 [10549283] Genetics. 1999 Jul;152(3):1025-35 [10388821] Science. 2000 Jun 16;288(5473):2013-8 [10856208] Mol Cell Biol. 2000 Jul;20(14):5300-9 [10866686] EMBO J. 2000 Jul 3;19(13):3398-407 [10880452] J Cell Biol. 2000 Jul 24;150(2):F31-6 [10908583] Curr Genet. 2000 Oct;38(3):113-25 [11057444] Mol Cell. 2001 Feb;7(2):263-72 [11239455] Science. 2001 Mar 30;291(5513):2600-2 [11283371] Genetics. 2001 Oct;159(2):515-25 [11606529] Genetics. 2002 Jul;161(3):1015-27 [12136007] Genetics. 1999 Jul;152(3):1037-44 [10388822] Genetics. 2004 Nov;168(3):1477-89 [15579700] Nucleic Acids Res. 2005 Jan 1;33(Database issue):D390-5 [15608223] Genetics. 2004 Dec;168(4):2067-76 [15611176] Genetics. 2005 Feb;169(2):795-806 [15545651] Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15167-72 [16203987] DNA Repair (Amst). 2005 Nov 21;4(11):1281-94 [16043424] Annu Rev Genet. 2005;39:431-51 [16285867] Genetics. 2006 Feb;172(2):1055-68 [16299390] Curr Biol. 2006 Oct 24;16(20):2009-15 [17055979] Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16370-5 [17060623] Nature. 2002 Nov 7;420(6911):93-8 [12422221] Mol Cell. 2002 Nov;10(5):1189-99 [12453425] Microbiol Mol Biol Rev. 2002 Dec;66(4):630-70, table of contents [12456786] Mol Cell. 2002 Dec;10(6):1503-9 [12504024] Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16840-5 [17075047] Genetics. 2007 Mar;175(3):1023-33 [17194776] PLoS Genet. 2007 Apr 13;3(4):e50 [17432935] Science. 2003 Jan 10;299(5604):265-7 [12522255] Genetics. 2003 Jun;164(2):589-601 [12807779] Mol Cell. 2003 Jul;12(1):209-19 [12887906] Mol Cell. 2003 Jul;12(1):221-32 [12887907] Genetics. 2003 Sep;165(1):197-204 [14504227] EMBO J. 2003 Nov 3;22(21):5863-74 [14592983] Genetics. 2003 Dec;165(4):1831-42 [14704169] Genetics. 2003 Dec;165(4):1929-41 [14704177] Development. 2004 Mar;131(5):1029-39 [14973288] Genetics. 2004 May;167(1):217-31 [15166149] Genetics. 2004 Jun;167(2):699-705 [15238522] Curr Biol. 2004 Aug 10;14(15):1348-53 [15296751] Mutat Res. 1973 Nov;20(2):215-20 [4356741] Mutat Res. 1974 Sep;24(3):281-92 [4606119] Genetics. 1976 Nov;84(3):507-26 [826451] Genetics. 1981 Mar-Apr;97(3-4):607-23 [6795083] Cell. 1983 May;33(1):25-35 [6380756] EMBO J. 1990 Mar;9(3):663-73 [2178924] Cell. 1990 Aug 10;62(3):515-25 [2165865] Genetics. 1992 Oct;132(2):387-402 [1427035] Nucleic Acids Res. 1993 Nov 11;21(22):5034-40 [8255757] Mol Cell Biol. 1994 Mar;14(3):1613-25 [8114699] EMBO J. 1994 Mar 15;13(6):1450-9 [7907981] Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):6064-8 [8016116] Mol Cell Biol. 1995 Apr;15(4):2245-51 [7891718] Cell. 1995 Sep 8;82(5):815-21 [7671309] Genetics. 1995 Oct;141(2):619-27 [8647398] Genetics. 1996 Mar;142(3):693-704 [8849880] Nucleic Acids Res. 1996 Dec 1;24(23):4639-48 [8972848] Nature. 1997 Jul 31;388(6641):495-8 [9242411] Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9214-9 [9256462] Nucleic Acids Res. 1997 Sep 15;25(18):3665-71 [9278488] Genes Dev. 1998 Sep 1;12(17):2711-23 [9732269] Microbiol Mol Biol Rev. 1999 Jun;63(2):349-404 [10357855] Cell. 1999 Dec 23;99(7):723-33 [10619426] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acute pesticide poisoning among cut-flower farmers. AN - 68302960; 17886581 AB - The study reported here looked at adverse health effects associated with pesticide exposure among cut-flower farmers in La Trinidad, Philippines. Survey questionnaires and detailed physical and laboratory examinations were administered to 114 and 102 respondents, respectively, to determine pesticide exposure, work and safety practices, individual and family illnesses, and cholinesterase levels. Results showed that pesticide application was the activity most frequently associated with pesticide exposure, and entry was mostly ocular and dermal. Involvement of the skin was noted, with 21 percent of farmers having integumentary abnormalities. Upon physical examination, 90 respondents, or 88.2 percent of those examined, were found to have abnormal peak expiratory flow rate (PEFR). Abnormal temperature was found in 81.3 percent, and the next most frequent finding was abnormal general-survey results, at 75.5 percent. In 51 percent, cholinesterase levels were below the mean value of 0.7 delta pH/hour. (The unit of measure A pH/hour refers to the change in cholinesterase activity as measured by the difference between the initial pH and the final pH when acetylcholine solution has been added to the red blood cell for 1 1/2 hours. A decrease in cholinesterase activity will produce a low delta pH/hour level) In 25.5 percent, a more than 10 percent depression in the level of RBC cholinesterase was found. Certain hematological parameters were also abnormal, namely hemoglobin, hematocrit, and eosinophil count. Using Pearson's r, the author found that factors strongly associated with illness due to pesticides include use of a contaminated piece of fabric to wipe off sweat (p = .01) and reuse of pesticide containers to store water (p = .01), Recycling of containers poses great health hazards and risks of contamination, and the current recommendation is that used containers should be buried. There was a moderate relationship between illness and average number of years of pesticide use (p = .05), and between illness and re-entering a recently sprayed area (p = .05). Those with motor scale scores of < or = 15--normal values--were less likely to be sick. The greatest adverse effect in those exposed was an abnormal cholinesterase level, a finding that confirms results from earlier studies on the effect of pesticides on the body. JF - Journal of environmental health AU - Lu, Jinky Leilanie AD - University of the Philippines, National Institutes of Health, Quezon City. jinky_lu@yahoo.com Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 38 EP - 43 VL - 70 IS - 2 SN - 0022-0892, 0022-0892 KW - Pesticides KW - 0 KW - Cholinesterases KW - EC 3.1.1.8 KW - Index Medicus KW - Agriculture KW - Flowers KW - Cholinesterases -- blood KW - Aged, 80 and over KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Aged KW - Middle Aged KW - Adolescent KW - Philippines -- epidemiology KW - Male KW - Female KW - Inhalation Exposure -- adverse effects KW - Agricultural Workers' Diseases -- epidemiology KW - Agricultural Workers' Diseases -- chemically induced KW - Occupational Exposure -- adverse effects KW - Agricultural Workers' Diseases -- blood KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68302960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+health&rft.atitle=Acute+pesticide+poisoning+among+cut-flower+farmers.&rft.au=Lu%2C+Jinky+Leilanie&rft.aulast=Lu&rft.aufirst=Jinky&rft.date=2007-09-01&rft.volume=70&rft.issue=2&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+health&rft.issn=00220892&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-02 N1 - Date created - 2007-09-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Real-time imaging of convection-enhanced delivery of viruses and virus-sized particles. AN - 68299763; 17886556 AB - Despite recent evidence showing that convection-enhanced delivery (CED) of viruses and virus-sized particles to the central nervous system (CNS) is possible, little is known about the factors influencing distribution of these vectors with convection. To better define the delivery of viruses and virus-sized particles in the CNS, and to determine optimal parameters for infusion, the authors coinfused adeno-associated virus ([AAV], 24-nm diameter) and/or ferumoxtran-10 (24 nm) by using CED during real-time magnetic resonance (MR) imaging. Sixteen rats underwent intrastriatal convective coinfusion with 4 microl of 35S-AAV capsids (0.5-1.0 x 10(14) viral particles/ml) and increasing concentrations (0.1, 0.5, 1, and 5 mg/ml) of a similar sized iron oxide MR imaging agent (ferumoxtran-10). Five nonhuman primates underwent either convective coinfusion of 35S-AAV capsids and 1 mg/ml ferumoxtran-10 (striatum, one animal) or infusion of 1 mg/ml ferumoxtran-10 alone (striatum in two animals; frontal white matter in two). Clinical effects, MR imaging studies, quantitative autoradiography, and histological data were analyzed. Real-time, T2-weighted MR imaging of ferumoxtran-10 during infusion revealed a clearly defined hypointense region of perfusion. Quantitative autoradiography confirmed that MR imaging of ferumoxtran-10 at a concentration of 1 mg/ml accurately tracked viral capsid distribution in the rat and primate brain (the mean difference in volume of distribution [Vd] was 7 and 15% in rats and primates, respectively). The Vd increased linearly with increasing volume of infusion (Vi) (R2 = 0.98). The mean Vd/Vi ratio was 4.1 +/- 0.2 (mean +/- standard error of the mean) in gray and 2.3 +/- 0.1 in white matter (p < 0.01). The distribution of infusate was homogeneous. Postinfusion MR imaging revealed leakback along the cannula track at infusion rates greater than 1.5 microl/minute in primate gray and white matter. No animal had clinical or histological evidence of toxicity. The CED method can be used to deliver AAV capsids and similar sized particles to the CNS safely and effectively over clinically relevant volumes. Moreover, real-time MR imaging of ferumoxtran-10 during infusion reveals that AAV capsids and similar sized particles have different convective delivery properties than smaller proteins and other compounds. JF - Journal of neurosurgery AU - Szerlip, Nicholas J AU - Walbridge, Stuart AU - Yang, Linda AU - Morrison, Paul F AU - Degen, Jeffrey W AU - Jarrell, S Taylor AU - Kouri, Joshua AU - Kerr, P Benjamin AU - Kotin, Robert AU - Oldfield, Edward H AU - Lonser, Russell R AD - Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1414, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 560 EP - 567 VL - 107 IS - 3 SN - 0022-3085, 0022-3085 KW - Contrast Media KW - 0 KW - Dextrans KW - Magnetite Nanoparticles KW - Oxides KW - ferumoxtran-10 KW - Iron KW - E1UOL152H7 KW - Ferrosoferric Oxide KW - XM0M87F357 KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Magnetic Resonance Imaging KW - Convection KW - Animals KW - Rats, Sprague-Dawley KW - Macaca fascicularis KW - Particle Size KW - Infusions, Parenteral KW - Image Processing, Computer-Assisted KW - Genetic Vectors -- administration & dosage KW - Oxides -- administration & dosage KW - Contrast Media -- pharmacokinetics KW - Iron -- administration & dosage KW - Iron -- pharmacokinetics KW - Oxides -- pharmacokinetics KW - Contrast Media -- administration & dosage KW - Brain -- metabolism KW - Genetic Vectors -- pharmacokinetics KW - Dependovirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68299763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurosurgery&rft.atitle=Real-time+imaging+of+convection-enhanced+delivery+of+viruses+and+virus-sized+particles.&rft.au=Szerlip%2C+Nicholas+J%3BWalbridge%2C+Stuart%3BYang%2C+Linda%3BMorrison%2C+Paul+F%3BDegen%2C+Jeffrey+W%3BJarrell%2C+S+Taylor%3BKouri%2C+Joshua%3BKerr%2C+P+Benjamin%3BKotin%2C+Robert%3BOldfield%2C+Edward+H%3BLonser%2C+Russell+R&rft.aulast=Szerlip&rft.aufirst=Nicholas&rft.date=2007-09-01&rft.volume=107&rft.issue=3&rft.spage=560&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurosurgery&rft.issn=00223085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-11 N1 - Date created - 2007-09-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Seroprevalence of hepatitis C virus and hepatitis B virus among San Francisco injection drug users, 1998 to 2000. AN - 68298838; 17657818 AB - Previous studies suggest that most injection drug users (IDUs) become infected with hepatitis C virus (HCV) and hepatitis B virus (HBV) soon after initiating drug use. The Urban Health Study (UHS) recruited serial cross-sections of IDUs in the San Francisco Bay area from 1986 to 2005. In the current study, we determined the prevalence of antibody to HCV and HBV (core) among UHS participants during 1998 to 2000. To examine whether the time from onset of injection to acquisition of viral hepatitis has increased, we also compared the findings among recent (<10 years) initiates to drug use who participated during 1998-2000 with those who participated in 1987. Of 2,296 IDUs who participated during 1998-2000, 91.1% had antibody to HCV and 80.5% to HBV. The number of years a person had injected drugs strongly predicted infection with either virus (P(trend) < 0.0001). HCV seroprevalence among recent initiates in 1998-2000, by years of injection drug use, was: 100% predicted) or poor (70% after only 20 mg/kg of busulfan. Similar levels of engraftment were achieved even when infusion of BMNCs was delayed up to 20 days after busulfan injection. Nonmyeloablative parenteral busulfan produced transient myelosuppressive effects, clinically relevant levels of engraftment, and an extended time window for HSC infusion in murine hosts. JF - Experimental hematology AU - Hsieh, Matthew M AU - Langemeijer, Saskia AU - Wynter, Aisha AU - Phang, Oswald A AU - Kang, Elizabeth M AU - Tisdale, John F AD - Molecular and Clinical Hematology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 1415 EP - 1420 VL - 35 IS - 9 SN - 0301-472X, 0301-472X KW - Busulfan KW - G1LN9045DK KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Graft Survival KW - Mice, Inbred C57BL KW - Mice KW - Time Factors KW - Infusions, Parenteral KW - Leukocyte Count KW - Platelet Count KW - Busulfan -- administration & dosage KW - Busulfan -- pharmacology KW - Hematopoietic Stem Cell Transplantation -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68219980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+hematology&rft.atitle=Low-dose+parenteral+busulfan+provides+an+extended+window+for+the+infusion+of+hematopoietic+stem+cells+in+murine+hosts.&rft.au=Hsieh%2C+Matthew+M%3BLangemeijer%2C+Saskia%3BWynter%2C+Aisha%3BPhang%2C+Oswald+A%3BKang%2C+Elizabeth+M%3BTisdale%2C+John+F&rft.aulast=Hsieh&rft.aufirst=Matthew&rft.date=2007-09-01&rft.volume=35&rft.issue=9&rft.spage=1415&rft.isbn=&rft.btitle=&rft.title=Experimental+hematology&rft.issn=0301472X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-01 N1 - Date created - 2007-08-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biol Blood Marrow Transplant. 2007 Jan;13(1):56-64 [17222753] Curr Opin Hematol. 2007 Jan;14(1):29-36 [17133097] Mol Ther. 2000 Jun;1(6):533-44 [10933978] Hum Gene Ther. 2007 Jan;18(1):1-9 [17173507] Exp Hematol. 2001 Jun;29(6):779-85 [11378274] Mol Ther. 2001 Jun;3(6):911-9 [11407905] J Immunol. 2001 Jul 15;167(2):1103-11 [11441122] Hum Gene Ther. 2001 Sep 1;12(13):1663-72 [11535169] N Engl J Med. 2002 Apr 18;346(16):1185-93 [11961146] J Clin Immunol. 2002 Mar;22(2):70-4 [11998895] Science. 2002 Jun 28;296(5577):2410-3 [12089448] Biol Blood Marrow Transplant. 2002;8(9):486-92 [12374453] Int J Hematol. 2002 Aug;76 Suppl 2:271-7 [12430936] Int J Hematol. 2003 Jan;77(1):3-14 [12568294] Hematology Am Soc Hematol Educ Program. 2003;:372-97 [14633791] Blood. 2004 Aug 1;104(3):857-64 [15073038] Semin Hematol. 2004 Oct;41(4):279-86 [15508113] J Natl Cancer Inst. 1974 Dec;53(6):1781-5 [4612168] Exp Hematol. 1974;2(3):101-17 [4616840] N Engl J Med. 1983 Dec 1;309(22):1347-53 [6355849] Transplantation. 1988 Aug;46(2):205-10 [3043777] Blood. 1991 Dec 15;78(12):3312-6 [1683798] Blood. 1996 May 15;87(10):4049-56 [8639760] N Engl J Med. 1996 Aug 8;335(6):369-76 [8663884] Hum Gene Ther. 1999 Jul 20;10(11):1783-90 [10446918] Lancet. 1953 Jan 31;264(6753):207-8 [13097986] Lancet. 1953 Jan 31;264(6753):208-13 [13097987] Mol Ther. 2006 Jan;13(1):26-41 [16280257] Transpl Immunol. 2006 Jan;15(3):199-204 [16431286] Exp Hematol. 2006 Feb;34(2):132-9 [16459181] Exp Hematol. 2006 Mar;34(3):369-81 [16543071] Nat Med. 2006 Apr;12(4):401-9 [16582916] Blood. 2006 Nov 15;108(10):3313-20 [16868255] Biol Blood Marrow Transplant. 2000;6(5A):548-54 [11071260] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Blunted rostral anterior cingulate response during a simplified decoding task of negative emotional facial expressions in alcoholic patients. AN - 68217566; 17624997 AB - Alcoholism is characterized by deficits in emotional functioning as well as by deficits in cognitive functioning. However, most brain imaging research on alcoholism has focused on cognition rather than emotion. We used an event-related functional magnetic imaging approach to examine alcoholics' brain blood oxygenation level dependent (BOLD) response to evaluation of emotional stimuli and to compare their response to that of nonalcoholic controls. The task used was a simplified variant of a facial emotion-decoding task in which subjects determined the intensity level of a target emotion displayed as a facial expression. Facial expressions of happy, sad, anger, disgust, and fear were used as stimuli. Alcoholics and controls did not differ in accurately identifying the intensity level on the simple emotional decoding task but there were significant differences in their BOLD response during evaluation of facial emotion. In general, alcoholics showed less brain activation than nonalcoholic controls. The greatest differences in activation were during decoding of facial expressions of fear and disgust during which alcoholics had significantly less activation than controls in the affective division of the anterior cingulate cortex (ACC). Alcoholics also had significantly less activation than controls in the affective division of the ACC, while viewing sad faces. Only to facial expressions of anger did the alcoholics show significant activation in the affective ACC and in this case, their BOLD response did not significantly differ from that of the controls. Alcoholics show a deficit in the function of the affective division of the ACC during evaluation of negative facial emotions that can serve as cues for flight or avoidance. This deficit may underlie some of the behavioral dysfunction in alcoholism. JF - Alcoholism, clinical and experimental research AU - Salloum, Jasmin B AU - Ramchandani, Vijay A AU - Bodurka, Jerzy AU - Rawlings, Robert AU - Momenan, Reza AU - George, David AU - Hommer, Daniel W AD - Laboratory of Clinical and Translational Studies, NIAAA, NIH, Bethesda, Maryland, USA. jasmins@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 1490 EP - 1504 VL - 31 IS - 9 SN - 0145-6008, 0145-6008 KW - Central Nervous System Depressants KW - 0 KW - Ethanol KW - 3K9958V90M KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Ethanol -- pharmacology KW - Oxygen -- metabolism KW - Humans KW - Interpersonal Relations KW - Central Nervous System Depressants -- pharmacology KW - Evoked Potentials KW - Adult KW - Case-Control Studies KW - Middle Aged KW - Affect KW - Expressed Emotion KW - Behavior -- physiology KW - Male KW - Visual Perception -- physiology KW - Facial Expression KW - Emotions KW - Gyrus Cinguli -- physiopathology KW - Alcoholism -- physiopathology KW - Visual Perception -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68217566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Blunted+rostral+anterior+cingulate+response+during+a+simplified+decoding+task+of+negative+emotional+facial+expressions+in+alcoholic+patients.&rft.au=Salloum%2C+Jasmin+B%3BRamchandani%2C+Vijay+A%3BBodurka%2C+Jerzy%3BRawlings%2C+Robert%3BMomenan%2C+Reza%3BGeorge%2C+David%3BHommer%2C+Daniel+W&rft.aulast=Salloum&rft.aufirst=Jasmin&rft.date=2007-09-01&rft.volume=31&rft.issue=9&rft.spage=1490&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-16 N1 - Date created - 2007-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Developmental exposure to diethylstilbestrol alters uterine gene expression that may be associated with uterine neoplasia later in life. AN - 68208986; 17394237 AB - Previously, we described a mouse model where the well-known reproductive carcinogen with estrogenic activity, diethylstilbestrol (DES), caused uterine adenocarcinoma following neonatal treatment. Tumor incidence was dose-dependent reaching >90% by 18 mo following neonatal treatment with 1000 microg/kg/d of DES. These tumors followed the initiation/promotion model of hormonal carcinogenesis with developmental exposure as initiator, and exposure to ovarian hormones at puberty as the promoter. To identify molecular pathways involved in DES-initiation events, uterine gene expression profiles were examined in prepubertal mice exposed to DES (1, 10, or 1000 microg/kg/d) on days 1-5 and compared to controls. Of more than 20 000 transcripts, approximately 3% were differentially expressed in at least one DES treatment group compared to controls; some transcripts demonstrated dose-responsiveness. Assessment of gene ontology annotation revealed alterations in genes associated with cell growth, differentiation, and adhesion. When expression profiles were compared to published studies of uteri from 5-d-old DES-treated mice, or adult mice treated with 17beta estradiol, similarities were seen suggesting persistent differential expression of estrogen responsive genes following developmental DES exposure. Moreover, several altered genes were identified in human uterine adenocarcinomas. Four altered genes [lactotransferrin (Ltf), transforming growth factor beta inducible (Tgfb1), cyclin D1 (Ccnd1), and secreted frizzled-related protein 4 (Sfrp4)], selected for real-time RT-PCR analysis, correlated well with the directionality of the microarray data. These data suggested altered gene expression profiles observed 2 wk after treatment ceased, were established at the time of developmental exposure and maybe related to the initiation events resulting in carcinogenesis. (c) 2007 Wiley-Liss, Inc. JF - Molecular carcinogenesis AU - Newbold, Retha R AU - Jefferson, Wendy N AU - Grissom, Sherry F AU - Padilla-Banks, Elizabeth AU - Snyder, Ryan J AU - Lobenhofer, Edward K AD - Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, NIEHS, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 783 EP - 796 VL - 46 IS - 9 SN - 0899-1987, 0899-1987 KW - Estradiol KW - 4TI98Z838E KW - Diethylstilbestrol KW - 731DCA35BT KW - Index Medicus KW - Animals KW - Oligonucleotide Array Sequence Analysis KW - Dose-Response Relationship, Drug KW - Estradiol -- pharmacology KW - Mice KW - Models, Biological KW - Pregnancy KW - Animals, Newborn KW - Gene Expression Profiling KW - Maternal-Fetal Exchange KW - Mice, Inbred Strains KW - Time Factors KW - Female KW - Prenatal Exposure Delayed Effects KW - Uterus -- metabolism KW - Gene Expression -- drug effects KW - Uterine Neoplasms -- genetics KW - Adenocarcinoma -- chemically induced KW - Uterine Neoplasms -- chemically induced KW - Diethylstilbestrol -- toxicity KW - Adenocarcinoma -- genetics KW - Uterus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68208986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Developmental+exposure+to+diethylstilbestrol+alters+uterine+gene+expression+that+may+be+associated+with+uterine+neoplasia+later+in+life.&rft.au=Newbold%2C+Retha+R%3BJefferson%2C+Wendy+N%3BGrissom%2C+Sherry+F%3BPadilla-Banks%2C+Elizabeth%3BSnyder%2C+Ryan+J%3BLobenhofer%2C+Edward+K&rft.aulast=Newbold&rft.aufirst=Retha&rft.date=2007-09-01&rft.volume=46&rft.issue=9&rft.spage=783&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=08991987&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-13 N1 - Date created - 2007-08-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Endocrinol. 2006 Jul;20(7):1535-46 [16513791] Endocrinology. 2006 Jun;147(6 Suppl):S11-7 [16690809] Cancer Res. 2003 Jan 1;63(1):6-11 [12517768] J Midwifery Womens Health. 2003 Jan-Feb;48(1):19-29 [12589302] Ann N Y Acad Sci. 2003 Mar;983:161-9 [12724221] J Pediatr Hematol Oncol. 2003 Aug;25(8):635-6 [12902917] Genome Biol. 2003;4(10):R70 [14519205] Mol Endocrinol. 2003 Oct;17(10):2070-83 [12893882] Reprod Toxicol. 2004 May;18(3):399-406 [15082075] Lab Anim Sci. 1999 Oct;49(5):530-6 [10551455] Mol Cell Endocrinol. 1999 Dec 20;158(1-2):1-5 [10630399] Cancer Res. 2000 Jan 15;60(2):235-7 [10667565] Mol Hum Reprod. 2000 May;6(5):469-73 [10775652] Toxicol Pathol. 2000 Mar-Apr;28(2):237-45 [10805141] FASEB J. 2000 Jun;14(9):1101-8 [10834931] Histol Histopathol. 2001 Jan;16(1):131-40 [11193187] Cancer Res. 2001 Jun 1;61(11):4325-8 [11389053] Dev Biol. 2001 Oct 15;238(2):224-38 [11784006] J Mol Endocrinol. 2002 Jun;28(3):213-23 [12063187] Nucleic Acids Res. 2002 Aug 15;30(16):e86 [12177314] Exp Biol Med (Maywood). 2002 Oct;227(9):709-23 [12324652] Nucleic Acids Res. 2001 May 1;29(9):e45 [11328886] Cancer Causes Control. 2002 Oct;13(8):753-8 [12420954] Toxicol Appl Pharmacol. 2004 Sep 1;199(2):142-50 [15313586] N Engl J Med. 1971 Apr 15;284(15):878-81 [5549830] J Natl Cancer Inst. 1979 Aug;63(2):507-18 [287840] Cancer Res. 1981 Feb;41(2):721-34 [7448817] Cancer Res. 1980 Nov;40(11):3988-99 [7193511] Science. 1981 Jun 19;212(4501):1402-4 [6262919] J Endocrinol. 1981 Nov;91(2):281-7 [7299327] Proc Soc Exp Biol Med. 1986 Jan;181(1):59-65 [3945625] Exp Mol Pathol. 1988 Feb;48(1):59-76 [3335252] Acta Anat (Basel). 1987;130(4):351-8 [3434191] Endocrinology. 1988 Jun;122(6):2355-63 [3286224] Mol Endocrinol. 1988 Sep;2(9):816-24 [3173352] Toxicology. 1988 Oct;51(2-3):201-12 [3176028] J Steroid Biochem. 1989 Mar;32(3):339-43 [2784840] J Biol Chem. 1989 Oct 5;264(28):16941-7 [2674144] Cancer Res. 1990 Dec 1;50(23):7677-81 [2174729] Mol Endocrinol. 1990 Jul;4(7):1041-50 [2126598] In Vitro Cell Dev Biol. 1992 May;28A(5):327-36 [1597405] J Natl Cancer Inst. 1993 Oct 6;85(19):1558-70 [8411230] Environ Health Perspect. 1993 Oct;101(5):378-84 [8080506] Cell Growth Differ. 1994 Jun;5(6):595-606 [8086337] Ann Intern Med. 1995 May 15;122(10):778-88 [7717601] Cancer. 1996 Feb 1;77(3):507-13 [8630958] Exp Clin Endocrinol Diabetes. 1996;104(2):111-22 [8740934] Anat Rec. 1996 Jul;245(3):459-71 [8800404] Biol Reprod. 1997 May;56(5):1147-57 [9160713] Cancer Res. 1997 Oct 1;57(19):4356-9 [9331098] Carcinogenesis. 1997 Dec;18(12):2293-8 [9450472] Dev Biol. 1998 May 15;197(2):141-54 [9630742] Toxicol Pathol. 1999 May-Jun;27(3):325-33 [10356709] Hum Mol Genet. 2005 Apr 15;14 Spec No 1:R149-55 [15809267] BMC Bioinformatics. 2005;6:168 [15998470] Bioinformatics. 2006 May 1;22(9):1111-21 [16522673] Mol Endocrinol. 2005 Mar;19(3):669-82 [15591538] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fibroblast growth factor receptor-1 is required for long-term potentiation, memory consolidation, and neurogenesis. AN - 68200980; 17239352 AB - Although substantial evidence supports the view that adult neurogenesis is involved in learning and memory, how newly generated neurons contribute to the cognitive process remains unknown. Fibroblast growth factor 2 (FGF-2) is known to stimulate the proliferation of neuronal progenitor cells (NPCs) in adult brain. Using conditional knockout mice that lack brain expression of FGFR1, a major receptor for FGF-2, we have investigated the role of adult neurogenesis in hippocampal synaptic plasticity and learning and memory. The Fgfr1 conditional knockout mice were generated by crossing the Fgfr1-null line, the Fgfr1-flox line, and the Nestin-Cre transgenic mice. Bromodeoxyuridine (BrdU) labeling, slice electrophysiology, and Morris Water Maze experiments were performed with the Fgfr1 conditional mutant mice. Bromodeoxyuridine labeling experiments demonstrate that FGFR1 is required for the proliferation of NPCs as well as generation of new neurons in the adult dentate gyrus (DG). Moreover, deficits in neurogenesis in Fgfr1 mutant mice are accompanied by a severe impairment of long-term potentiation (LTP) at the medial perforant path (MPP)-granule neuron synapses in the hippocampal dentate. Moreover, the Fgfr1 mutant mice exhibit significant deficits in memory consolidation but not spatial learning. Our study suggests a critical role of FGFR1 in adult neurogenesis in vivo, provides a potential link between proliferative neurogenesis and dentate LTP, and raises the possibility that adult neurogenesis might contribute to memory consolidation. JF - Biological psychiatry AU - Zhao, Mingrui AU - Li, Dan AU - Shimazu, Kazuhiro AU - Zhou, Yong-Xing AU - Lu, Bai AU - Deng, Chu-Xia AD - Section on Neural Development and Plasticity, Laboratory of Cellular & Synaptic Neurophysiology, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA. Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - 381 EP - 390 VL - 62 IS - 5 SN - 0006-3223, 0006-3223 KW - Glial Fibrillary Acidic Protein KW - 0 KW - Intermediate Filament Proteins KW - NES protein, human KW - Nerve Tissue Proteins KW - Nes protein, mouse KW - Nestin KW - Fgfr1 protein, mouse KW - EC 2.7.10.1 KW - Receptor, Fibroblast Growth Factor, Type 1 KW - Phosphopyruvate Hydratase KW - EC 4.2.1.11 KW - Bromodeoxyuridine KW - G34N38R2N1 KW - Index Medicus KW - Patch-Clamp Techniques -- methods KW - Animals KW - Electric Stimulation -- methods KW - Cell Count KW - Maze Learning -- physiology KW - Medial Forebrain Bundle -- physiology KW - Glial Fibrillary Acidic Protein -- metabolism KW - Mice KW - Dose-Response Relationship, Radiation KW - Nerve Tissue Proteins -- genetics KW - Mice, Transgenic KW - Reaction Time -- physiology KW - Behavior, Animal KW - Reaction Time -- radiation effects KW - Medial Forebrain Bundle -- radiation effects KW - Intermediate Filament Proteins -- genetics KW - Phosphopyruvate Hydratase -- metabolism KW - Hippocampus -- cytology KW - In Vitro Techniques KW - Mutation KW - Bromodeoxyuridine -- metabolism KW - Long-Term Potentiation -- genetics KW - Receptor, Fibroblast Growth Factor, Type 1 -- deficiency KW - Long-Term Potentiation -- physiology KW - Neurons -- physiology KW - Memory -- physiology KW - Receptor, Fibroblast Growth Factor, Type 1 -- physiology KW - Cell Proliferation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68200980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Fibroblast+growth+factor+receptor-1+is+required+for+long-term+potentiation%2C+memory+consolidation%2C+and+neurogenesis.&rft.au=Zhao%2C+Mingrui%3BLi%2C+Dan%3BShimazu%2C+Kazuhiro%3BZhou%2C+Yong-Xing%3BLu%2C+Bai%3BDeng%2C+Chu-Xia&rft.aulast=Zhao&rft.aufirst=Mingrui&rft.date=2007-09-01&rft.volume=62&rft.issue=5&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-26 N1 - Date created - 2007-08-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons. AN - 68200157; 17626162 AB - Under normal conditions, the proline-directed serine/threonine residues of neurofilament tail-domain repeats are exclusively phosphorylated in axons. In pathological conditions such as amyotrophic lateral sclerosis (ALS), motor neurons contain abnormal perikaryal accumulations of phosphorylated neurofilament proteins. The precise mechanisms for this compartment-specific phosphorylation of neurofilaments are not completely understood. Although localization of kinases and phosphatases is certainly implicated, another possibility involves Pin1 modulation of phosphorylation of the proline-directed serine/threonine residues. Pin1, a prolyl isomerase, selectively binds to phosphorylated proline-directed serine/threonine residues in target proteins and isomerizes cis isomers to more stable trans configurations. In this study we show that Pin1 associates with phosphorylated neurofilament-H (p-NF-H) in neurons and is colocalized in ALS-affected spinal cord neuronal inclusions. To mimic the pathology of neurodegeneration, we studied glutamate-stressed neurons that displayed increased p-NF-H in perikaryal accumulations that colocalized with Pin1 and led to cell death. Both effects were reduced upon inhibition of Pin1 activity by the use of an inhibitor juglone and down-regulating Pin1 levels through the use of Pin1 small interfering RNA. Thus, isomerization of lys-ser-pro repeat residues that are abundant in NF-H tail domains by Pin1 can regulate NF-H phosphorylation, which suggests that Pin1 inhibition may be an attractive therapeutic target to reduce pathological accumulations of p-NF-H. JF - Molecular biology of the cell AU - Kesavapany, Sashi AU - Patel, Vyomesh AU - Zheng, Ya-Li AU - Pareek, Tej K AU - Bjelogrlic, Mia AU - Albers, Wayne AU - Amin, Niranjana AU - Jaffe, Howard AU - Gutkind, J Silvio AU - Strong, Michael J AU - Grant, Philip AU - Pant, Harish C AD - Cytoskeletal Protein Regulation Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 3645 EP - 3655 VL - 18 IS - 9 SN - 1059-1524, 1059-1524 KW - NIMA-Interacting Peptidylprolyl Isomerase KW - 0 KW - Naphthoquinones KW - Neurofilament Proteins KW - RNA, Small Interfering KW - neurofilament protein H KW - 108688-71-7 KW - Glutamic Acid KW - 3KX376GY7L KW - PIN1 protein, human KW - EC 5.2.1.8 KW - Peptidylprolyl Isomerase KW - juglone KW - W6Q80SK9L6 KW - Index Medicus KW - Animals KW - Protein Transport -- drug effects KW - Humans KW - Naphthoquinones -- pharmacology KW - RNA, Small Interfering -- metabolism KW - Alzheimer Disease -- enzymology KW - Models, Biological KW - Protein Structure, Quaternary KW - Phosphorylation -- drug effects KW - Rats KW - Ganglia, Spinal -- cytology KW - Amyotrophic Lateral Sclerosis -- pathology KW - Amyotrophic Lateral Sclerosis -- enzymology KW - Genes, Dominant KW - Transfection KW - Protein Binding -- drug effects KW - Spinal Cord -- drug effects KW - Apoptosis -- drug effects KW - Spinal Cord -- pathology KW - Alzheimer Disease -- pathology KW - Ganglia, Spinal -- enzymology KW - Peptidylprolyl Isomerase -- antagonists & inhibitors KW - Glutamic Acid -- toxicity KW - Cell Nucleus -- metabolism KW - Neurons -- drug effects KW - Neurons -- enzymology KW - Neurofilament Proteins -- metabolism KW - Cell Nucleus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68200157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+biology+of+the+cell&rft.atitle=Inhibition+of+Pin1+reduces+glutamate-induced+perikaryal+accumulation+of+phosphorylated+neurofilament-H+in+neurons.&rft.au=Kesavapany%2C+Sashi%3BPatel%2C+Vyomesh%3BZheng%2C+Ya-Li%3BPareek%2C+Tej+K%3BBjelogrlic%2C+Mia%3BAlbers%2C+Wayne%3BAmin%2C+Niranjana%3BJaffe%2C+Howard%3BGutkind%2C+J+Silvio%3BStrong%2C+Michael+J%3BGrant%2C+Philip%3BPant%2C+Harish+C&rft.aulast=Kesavapany&rft.aufirst=Sashi&rft.date=2007-09-01&rft.volume=18&rft.issue=9&rft.spage=3645&rft.isbn=&rft.btitle=&rft.title=Molecular+biology+of+the+cell&rft.issn=10591524&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-09 N1 - Date created - 2007-08-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neurobiol Dis. 2004 Nov;17(2):237-49 [15474361] Biochem Biophys Res Commun. 2004 Aug 13;321(1):210-8 [15358237] Proc Natl Acad Sci U S A. 1985 Jun;82(12):4274-6 [3159022] J Neuropathol Exp Neurol. 1986 Jan;45(1):56-64 [3510274] Neurosci Lett. 1986 Mar 14;64(3):253-8 [2421208] J Neurosci. 1987 Nov;7(11):3474-88 [3119789] FEBS Lett. 1988 Jun 6;233(1):181-5 [3384089] Neurosci Lett. 1988 Oct 17;92(3):291-7 [2462197] Acta Neuropathol. 1992;83(3):240-5 [1557955] Brain Res. 1993 Feb 12;603(1):121-4 [7680936] Mol Biol Cell. 1994 Feb;5(2):161-72 [8019002] J Cell Biol. 1994 Aug;126(4):1031-46 [7519617] Biochem J. 1995 Aug 1;309 ( Pt 3):941-9 [7639714] Nature. 1996 Apr 11;380(6574):544-7 [8606777] Biochem Cell Biol. 1995 Sep-Oct;73(9-10):575-92 [8714676] J Cell Sci. 1996 Sep;109 ( Pt 9):2319-29 [8886982] J Neuropathol Exp Neurol. 1997 May;56(5):523-30 [9143265] Biochemistry. 1998 Mar 17;37(11):3931-40 [9521714] Biochemistry. 1998 Nov 17;37(46):16211-24 [9819213] Nature. 1999 Jun 24;399(6738):784-8 [10391244] Biochim Biophys Acta. 2005 Jan 3;1739(2-3):280-97 [15615646] Curr Opin Struct Biol. 2005 Feb;15(1):35-41 [15718131] J Mol Biol. 2005 Apr 8;347(4):827-39 [15769473] Nat Cell Biol. 2005 May;7(5):435-41 [15867923] J Biol Chem. 2006 Feb 17;281(7):4117-25 [16365047] Neuron. 2006 Mar 2;49(5):655-62 [16504941] Neurobiol Aging. 2006 Jul;27(7):918-25 [15950321] Pharmacol Ther. 2006 Jul;111(1):99-113 [16274748] Mol Cell Neurosci. 2006 May-Jun;32(1-2):155-60 [16697218] Biol Bull. 2006 Jun;210(3):318-33 [16801505] J Biol Chem. 2006 Jul 14;281(28):19296-304 [16675464] Sci STKE. 2006 Aug 22;2006(349):pe32 [16926362] J Neurochem. 2006 Sep;98(6):1697-706 [16945100] Acta Neuropathol. 1990;79(4):402-8 [2111074] J Biol Chem. 2001 Jul 6;276(27):25150-6 [11313338] J Biol Chem. 2001 Aug 17;276(33):31163-70 [11333266] FEBS Lett. 2001 Oct 19;507(1):81-7 [11682063] J Biol Chem. 2002 Jan 25;277(4):2381-4 [11723108] Acta Neuropathol. 2002 Jan;103(1):26-35 [11837744] J Neuropathol Exp Neurol. 2002 Jun;61(6):557-64 [12071639] Bioessays. 2003 Feb;25(2):174-81 [12539244] Bioessays. 2003 Apr;25(4):346-55 [12655642] Neurochem Res. 2003 Jul;28(7):1041-7 [12737529] J Biol Chem. 2003 Jun 27;278(26):24026-32 [12695506] Nature. 2003 Jul 31;424(6948):556-61 [12891359] Biochem Pharmacol. 2003 Oct 15;66(8):1619-25 [14555242] Genes Dev. 2003 Nov 15;17(22):2765-76 [14600023] J Cell Sci. 2004 Feb 29;117(Pt 6):933-41 [14762105] J Neurobiol. 2004 Mar;58(4):514-28 [14978728] Trends Biochem Sci. 2004 Apr;29(4):200-9 [15082314] Am J Pathol. 2004 May;164(5):1727-37 [15111319] J Neurosci. 2004 May 5;24(18):4421-31 [15128856] J Mol Biol. 2004 Jun 4;339(3):635-46 [15147846] J Cell Sci. 2000 Feb;113 ( Pt 3):401-7 [10639328] Neuropharmacology. 2000 Feb 14;39(4):621-30 [10728883] Nature. 2000 May 18;405(6784):360-4 [10830966] Mol Cell. 2000 Oct;6(4):873-83 [11090625] Nucleic Acids Res. 2001 Feb 1;29(3):767-73 [11160900] J Neurochem. 2001 Mar;76(5):1315-25 [11238716] J Neurosci. 2001 Jul 1;21(13):4572-81 [11425885] EMBO J. 2004 Aug 18;23(16):3397-407 [15257284] J Biol Chem. 1982 Sep 10;257(17):10467-70 [7202005] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reconstitution of FOXP3+ regulatory T cells (Tregs) after CD25-depleted allotransplantation in elderly patients and association with acute graft-versus-host disease. AN - 68189204; 17478639 AB - Selective depletion (SD) of host-reactive donor T cells from allogeneic stem-cell transplants (SCTs) using an anti-CD25 immunotoxin (IT) is a strategy to prevent acute graft-versus-host disease (aGvHD). There is concern that concurrent removal of regulatory T cells (T(regs)) with incomplete removal of alloactivated CD25(+) T cells could increase the risk of aGvHD. We therefore measured T(regs) in the blood of 16 patients receiving a T-cell-depleted allograft together with anti-CD25-IT-treated SD lymphocytes, in 13 of their HLA-identical donors, and in 10 SD products. T(regs) were characterized by intracellular staining for forkhead box protein 3 (FOXP3) and by quantitative reverse-transcription-polymerase chain reaction (qRT-PCR) for FOXP3 gene in CD4(+) cells. Patients received a median of 1.0 x 10(8)/kg SD T cells and a stem cell product containing a median of 0.25 x 10(4)/kg residual T cells. T(regs) reconstituted promptly after SCT and underwent further expansion. Of the CD4(+) T cells in SD products, 1.5% to 4.8% were CD25(-) T(regs). Acute GvHD (>or= grade II) was restricted to 5 patients whose donors had significantly (P = .019) fewer T(regs) compared with those without clinically significant aGvHD. These results suggest that rapid T(reg) reconstitution can occur following SD allografts, either from CD25(-) T(regs) escaping depletion, or from residual CD25(-) and CD25(+) T(regs) contained in the stem-cell product that expand after transplantation and may confer additional protection against GvHD. JF - Blood AU - Mielke, Stephan AU - Rezvani, Katayoun AU - Savani, Bipin N AU - Nunes, Raquel AU - Yong, Agnes S M AU - Schindler, John AU - Kurlander, Roger AU - Ghetie, Victor AU - Read, Elizabeth J AU - Solomon, Scott R AU - Vitetta, Ellen S AU - Barrett, A John AD - Allotransplantation Section, Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892-1202, USA. mielkes@nhlbi.nih.gov Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - 1689 EP - 1697 VL - 110 IS - 5 SN - 0006-4971, 0006-4971 KW - FOXP3 protein, human KW - 0 KW - Forkhead Transcription Factors KW - Immunotoxins KW - Interleukin-2 Receptor alpha Subunit KW - Abridged Index Medicus KW - Index Medicus KW - Acute Disease KW - Hematopoietic Stem Cells -- immunology KW - Immunotoxins -- immunology KW - Risk Factors KW - Humans KW - Aged KW - Middle Aged KW - Interleukin-2 Receptor alpha Subunit -- immunology KW - Follow-Up Studies KW - Transplantation, Homologous KW - Immunotoxins -- pharmacology KW - Male KW - Female KW - Forkhead Transcription Factors -- immunology KW - Peripheral Blood Stem Cell Transplantation KW - Recovery of Function -- immunology KW - Graft vs Host Disease -- immunology KW - Forkhead Transcription Factors -- biosynthesis KW - Lymphocyte Depletion -- adverse effects KW - Graft vs Host Disease -- blood KW - T-Lymphocytes, Regulatory -- immunology KW - Living Donors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68189204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Reconstitution+of+FOXP3%2B+regulatory+T+cells+%28Tregs%29+after+CD25-depleted+allotransplantation+in+elderly+patients+and+association+with+acute+graft-versus-host+disease.&rft.au=Mielke%2C+Stephan%3BRezvani%2C+Katayoun%3BSavani%2C+Bipin+N%3BNunes%2C+Raquel%3BYong%2C+Agnes+S+M%3BSchindler%2C+John%3BKurlander%2C+Roger%3BGhetie%2C+Victor%3BRead%2C+Elizabeth+J%3BSolomon%2C+Scott+R%3BVitetta%2C+Ellen+S%3BBarrett%2C+A+John&rft.aulast=Mielke&rft.aufirst=Stephan&rft.date=2007-09-01&rft.volume=110&rft.issue=5&rft.spage=1689&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-19 N1 - Date created - 2007-08-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Haematol. 2000 Jun;109(3):644-51 [10886218] Blood. 2004 Dec 1;104(12):3429-36 [15284108] J Immunol. 2000 Nov 1;165(9):4901-9 [11046015] Blood. 2002 Apr 15;99(8):3041-9 [11929798] Blood. 2002 May 1;99(9):3083-8 [11964269] Blood. 2002 May 15;99(10):3493-9 [11986199] Blood. 2002 Jun 15;99(12):4601-9 [12036894] Blood. 2002 Jul 15;100(2):375-82 [12091325] Lancet. 2002 Jul 13;360(9327):130-7 [12126823] J Exp Med. 2002 Aug 5;196(3):389-99 [12163567] Curr Opin Hematol. 2002 Nov;9(6):490-6 [12394170] Cytotherapy. 2002;4(5):395-406 [12473206] Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1180-4 [12531922] Science. 2003 Feb 14;299(5609):1057-61 [12522256] Nat Immunol. 2003 Apr;4(4):330-6 [12612578] Nat Immunol. 2003 Apr;4(4):337-42 [12612581] Neoplasma. 2003;50(4):296-9 [12937844] Nat Med. 2003 Sep;9(9):1144-50 [12925844] Blood. 2003 Sep 15;102(6):2292-9 [12763937] J Clin Invest. 2003 Nov;112(9):1310-2 [14597756] J Clin Invest. 2003 Nov;112(9):1437-43 [14597769] Blood. 2004 Feb 1;103(3):1158-65 [14525783] Biol Blood Marrow Transplant. 2004 Aug;10(8):552-60 [15282533] J Exp Med. 2005 Jun 6;201(11):1793-803 [15939793] Blood. 2005 Aug 1;106(3):1123-9 [15817673] Cytotherapy. 2005;7(2):109-15 [16040390] Blood. 2005 Oct 15;106(8):2903-11 [15972448] Nat Med. 2005 Nov;11(11):1238-43 [16227988] Bone Marrow Transplant. 2006 Feb;37(3):297-305 [16327814] Blood. 2006 Feb 15;107(4):1717-23 [16278306] Bone Marrow Transplant. 2006 Mar;37(6):559-67 [16444279] J Immunol. 2006 Jun 1;176(11):6586-93 [16709816] Blood. 2006 Aug 15;108(4):1291-7 [16627754] Immunol Rev. 2006 Aug;212:8-27 [16903903] Blood. 2006 Sep 15;108(6):1797-808 [16741253] Blood. 2007 Jan 1;109(1):365-73 [16931626] Blood. 2008 Apr 15;111(8):4392-402 [17878399] Blood. 2004 Oct 1;104(7):2187-93 [15172973] Transplantation. 1990 Jul;50(1):1-7 [2142343] N Engl J Med. 1991 Mar 7;324(10):667-74 [1994250] Blood. 1994 Jun 15;83(12):3815-25 [7515723] J Immunol. 1995 Aug 1;155(3):1151-64 [7636184] Bone Marrow Transplant. 1996 May;17(5):793-9 [8733700] Genome Res. 1996 Oct;6(10):986-94 [8908518] J Immunol Methods. 1997 Dec 29;210(2):195-203 [9520302] Br J Haematol. 1999 Oct;107(1):169-75 [10520038] Bone Marrow Transplant. 2000 May;25 Suppl 2:S39-42 [10933186] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of the catalytic metal during polymerization by DNA polymerase lambda. AN - 68177083; 17475573 AB - The incorporation of dNMPs into DNA by polymerases involves a phosphoryl transfer reaction hypothesized to require two divalent metal ions. Here we investigate this hypothesis using as a model human DNA polymerase lambda (Pol lambda), an enzyme suggested to be activated in vivo by manganese. We report the crystal structures of four complexes of human Pol lambda. In a 1.9 A structure of Pol lambda containing a 3'-OH and the non-hydrolyzable analog dUpnpp, a non-catalytic Na+ ion occupies the site for metal A and the ribose of the primer-terminal nucleotide is found in a conformation that positions the acceptor 3'-OH out of line with the alpha-phosphate and the bridging oxygen of the pyrophosphate leaving group. Soaking this crystal in MnCl2 yielded a 2.0 A structure with Mn2+ occupying the site for metal A. In the presence of Mn2+, the conformation of the ribose is C3'-endo and the 3'-oxygen is in line with the leaving oxygen, at a distance from the phosphorus atom of the alpha-phosphate (3.69 A) consistent with and supporting a catalytic mechanism involving two divalent metal ions. Finally, soaking with MnCl2 converted a pre-catalytic Pol lambda/Na+ complex with unreacted dCTP in the active site into a product complex via catalysis in the crystal. These data provide pre- and post-transition state information and outline in a single crystal the pathway for the phosphoryl transfer reaction carried out by DNA polymerases. JF - DNA repair AU - Garcia-Diaz, Miguel AU - Bebenek, Katarzyna AU - Krahn, Joseph M AU - Pedersen, Lars C AU - Kunkel, Thomas A AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - 1333 EP - 1340 VL - 6 IS - 9 SN - 1568-7864, 1568-7864 KW - Phosphates KW - 0 KW - Manganese KW - 42Z2K6ZL8P KW - DNA KW - 9007-49-2 KW - DNA Polymerase beta KW - EC 2.7.7.- KW - DNA polymerase beta2 KW - Index Medicus KW - Phosphates -- metabolism KW - Crystallization KW - Models, Molecular KW - Humans KW - Crystallography, X-Ray KW - Protein Binding KW - Protein Conformation KW - Catalysis KW - Binding Sites KW - Manganese -- pharmacology KW - DNA Polymerase beta -- genetics KW - DNA -- metabolism KW - DNA Polymerase beta -- chemistry KW - DNA -- chemistry KW - DNA Polymerase beta -- metabolism KW - Mutagenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68177083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+repair&rft.atitle=Role+of+the+catalytic+metal+during+polymerization+by+DNA+polymerase+lambda.&rft.au=Garcia-Diaz%2C+Miguel%3BBebenek%2C+Katarzyna%3BKrahn%2C+Joseph+M%3BPedersen%2C+Lars+C%3BKunkel%2C+Thomas+A&rft.aulast=Garcia-Diaz&rft.aufirst=Miguel&rft.date=2007-09-01&rft.volume=6&rft.issue=9&rft.spage=1333&rft.isbn=&rft.btitle=&rft.title=DNA+repair&rft.issn=15687864&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-25 N1 - Date created - 2007-08-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2001 Sep 14;276(37):34659-63 [11457865] Mol Cell. 2005 Aug 5;19(3):357-66 [16061182] Proteins. 2003 Feb 15;50(3):437-50 [12557186] Biochemistry. 2003 Jun 24;42(24):7467-76 [12809503] Biochemistry. 2003 Aug 19;42(32):9564-74 [12911298] J Biol Chem. 2003 Sep 5;278(36):34685-90 [12829698] J Biol Chem. 2004 Jan 2;279(1):805-11 [14561766] Mol Cell. 2004 Feb 27;13(4):561-72 [14992725] Biochemistry. 2004 Jun 1;43(21):6751-62 [15157109] J Biol Chem. 1972 Nov 10;247(21):6784-94 [4343158] J Biol Chem. 1979 Aug 10;254(15):6889-93 [378995] J Biol Chem. 1990 Aug 25;265(24):14327-34 [2201684] EMBO J. 1991 Jan;10(1):25-33 [1989886] Acta Crystallogr A. 1991 Mar 1;47 ( Pt 2):110-9 [2025413] Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):905-21 [9757107] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765] Mol Cell. 2004 Dec 3;16(5):701-13 [15574326] Nat Struct Mol Biol. 2005 Jan;12(1):97-8 [15608652] J Biol Chem. 2005 May 6;280(18):18469-75 [15749700] EMBO J. 2005 Sep 7;24(17):2957-67 [16107880] J Biol Chem. 2005 Sep 9;280(36):31641-7 [16002405] DNA Repair (Amst). 2005 Dec 8;4(12):1358-67 [16213194] Cell. 2006 Jan 27;124(2):331-42 [16439207] Mol Cell. 2006 Apr 7;22(1):5-13 [16600865] Structure. 2006 Apr;14(4):757-66 [16615916] Nucleic Acids Res. 2006;34(11):3259-66 [16807316] Immunity. 2006 Jul;25(1):31-41 [16860755] Radiat Res. 2006 Nov;166(5):693-714 [17067213] Annu Rev Biochem. 2002;71:133-63 [12045093] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cyclooxygenase-2 deficiency exacerbates bleomycin-induced lung dysfunction but not fibrosis. AN - 68174293; 17496151 AB - Cyclooxygenase (COX)-derived eicosanoids have been implicated in the pathogenesis of pulmonary fibrosis. Uncertainty regarding the influence of COX-2 on experimental pulmonary fibrosis prompted us to clarify the fibrotic and functional effects of intratracheal bleomycin administration in mice genetically deficient in COX-2. Further, the effects of airway-specific COX-1 overexpression on fibrotic and functional outcomes in wild-type and COX-2 knockout mice were assessed. Equivalent increases in airway cell influx, lung collagen content, and histopathologic evidence of fibrosis were observed in wild-type and COX-2 knockout mice 21 d after bleomycin treatment, suggesting that COX-2 deficiency did not alter the extent or severity of fibrosis in this model. However, bleomycin-induced alterations in respiratory mechanics were more severe in COX-2 knockout mice than in wild-type mice, as illustrated by a greater decrease in static compliance compared with genotype-matched, saline-treated control mice (26 +/- 3% versus 11 +/- 4% decreases for COX-2 knockout and wild-type mice, respectively; P < 0.05). The influence of COX-1 overexpression in airway Clara cells was also examined. Whereas the fibrotic effects of bleomycin were not altered in wild-type or COX-2 knockout mice overexpressing COX-1, the exaggerated lung function decrement in bleomycin-treated COX-2 knockout mice was prevented by COX-1 overexpression and coincided with decreased airway cysteinyl leukotriene levels. Collectively, these data suggest an important regulatory role for COX-2 in the maintenance of lung function in the setting of lung fibrosis, but not in the progression of the fibrotic process per se. JF - American journal of respiratory cell and molecular biology AU - Card, Jeffrey W AU - Voltz, James W AU - Carey, Michelle A AU - Bradbury, J Alyce AU - Degraff, Laura M AU - Lih, Fred B AU - Bonner, James C AU - Morgan, Daniel L AU - Flake, Gordon P AU - Zeldin, Darryl C AD - Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, NC 27709, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 300 EP - 308 VL - 37 IS - 3 SN - 1044-1549, 1044-1549 KW - Eicosanoids KW - 0 KW - Recombinant Proteins KW - Bleomycin KW - 11056-06-7 KW - Ptgs2 protein, mouse KW - EC 1.14.99.- KW - Cyclooxygenase 1 KW - EC 1.14.99.1 KW - Cyclooxygenase 2 KW - Index Medicus KW - Animals KW - Cyclooxygenase 1 -- metabolism KW - Pulmonary Fibrosis -- etiology KW - Eicosanoids -- metabolism KW - Humans KW - Gene Expression KW - Cyclooxygenase 1 -- genetics KW - Mice KW - Recombinant Proteins -- genetics KW - Mice, Transgenic KW - Pulmonary Fibrosis -- metabolism KW - Mice, Knockout KW - Respiratory Mechanics KW - Recombinant Proteins -- metabolism KW - Pulmonary Fibrosis -- pathology KW - Mice, Inbred C57BL KW - Female KW - Cyclooxygenase 2 -- deficiency KW - Cyclooxygenase 2 -- genetics KW - Lung -- drug effects KW - Bleomycin -- toxicity KW - Lung -- enzymology KW - Lung -- pathology KW - Lung -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68174293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=Cyclooxygenase-2+deficiency+exacerbates+bleomycin-induced+lung+dysfunction+but+not+fibrosis.&rft.au=Card%2C+Jeffrey+W%3BVoltz%2C+James+W%3BCarey%2C+Michelle+A%3BBradbury%2C+J+Alyce%3BDegraff%2C+Laura+M%3BLih%2C+Fred+B%3BBonner%2C+James+C%3BMorgan%2C+Daniel+L%3BFlake%2C+Gordon+P%3BZeldin%2C+Darryl+C&rft.aulast=Schooler&rft.aufirst=Carmi&rft.date=2007-05-01&rft.volume=62B&rft.issue=3&rft.spage=P165&rft.isbn=&rft.btitle=&rft.title=Journals+of+Gerontology+Series+B%3A+Psychological+Sciences+and+Social+Sciences&rft.issn=10795014&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-19 N1 - Date created - 2007-08-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am Rev Respir Dis. 1982 Mar;125(3):290-4 [6279000] Am Rev Respir Dis. 1979 Jul;120(1):67-73 [88916] Respiration. 1987;51(4):256-65 [3116626] J Clin Pathol. 1988 Apr;41(4):467-70 [3366935] J Clin Invest. 1995 Apr;95(4):1861-8 [7706493] Lung. 1996;174(5):315-23 [8843057] J Appl Physiol. 1964 Jan;19:97-104 [14104296] Am J Respir Crit Care Med. 2005 Mar 15;171(6):639-44 [15640368] Clin Sci (Lond). 2005 Jun;108(6):479-91 [15896193] Crit Rev Immunol. 2005;25(6):429-63 [16390322] J Immunol. 2006 Jul 1;177(1):621-30 [16785560] Am J Physiol Lung Cell Mol Physiol. 2006 Aug;291(2):L144-56 [16473862] Pharmacol Rev. 2006 Sep;58(3):375-88 [16968946] J Immunol. 2006 Oct 1;177(7):4785-93 [16982919] Am J Respir Crit Care Med. 2006 Oct 1;174(7):803-9 [16825656] Respir Res. 2006;7:137 [17118201] Circ Res. 2001 Mar 30;88(6):593-9 [11282893] Am J Pathol. 2001 Apr;158(4):1411-22 [11290559] Am J Respir Crit Care Med. 2002 Jan 15;165(2):229-35 [11790660] Am J Respir Cell Mol Biol. 2002 Mar;26(3):277-82 [11867335] Am J Pathol. 2002 Aug;161(2):459-70 [12163371] Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):277-82 [12493843] Crit Care Med. 2003 May;31(5):1442-8 [12771616] Am J Respir Crit Care Med. 2003 Dec 1;168(11):1358-65 [14644925] Circ Res. 2003 Nov 28;93(11):1089-94 [14563714] Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3047-52 [14970333] Am J Pathol. 2004 Nov;165(5):1663-76 [15509536] Prostaglandins. 1986 Nov;32(5):769-80 [3823489] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nuclear receptor corepressor is a novel regulator of phosphatidylinositol 3-kinase signaling. AN - 68171439; 17606624 AB - The nuclear receptor corepressor (NCoR) regulates the activities of DNA-binding transcription factors. Recent observations of its distribution in the extranuclear compartment raised the possibility that it could have other cellular functions in addition to transcription repression. We previously showed that phosphatidylinositol 3-kinase (PI3K) signaling is aberrantly activated by a mutant thyroid hormone beta receptor (TRbetaPV, hereafter referred to as PV) via physical interaction with p85alpha, thus contributing to thyroid carcinogenesis in a mouse model of follicular thyroid carcinoma (TRbetaPV/PV mouse). Since NCoR is known to modulate the actions of TRbeta mutants in vivo and in vitro, we asked whether NCoR regulates PV-activated PI3K signaling. Remarkably, we found that NCoR physically interacted with and competed with PV for binding to the C-terminal SH2 (Src homology 2) domain of p85alpha, the regulatory subunit of PI3K. Confocal fluorescence microscopy showed that both NCoR and p85alpha were localized in the nuclear as well as in the cytoplasmic compartments. Overexpression of NCoR in thyroid tumor cells of TRbetaPV/PV mouse reduced PI3K signaling, as indicated by the decrease in the phosphorylation of its immediate downstream effector, p-AKT. Conversely, lowering cellular NCoR by siRNA knockdown in tumor cells led to overactivated p-AKT and increased cell proliferation and motility. Furthermore, NCoR protein levels were significantly lower in thyroid tumor cells than in wild-type thyrocytes, allowing more effective binding of PV to p85alpha to activate PI3K signaling and thus contributing to tumor progression. Taken together, these results indicate that NCoR, via protein-protein interaction, is a novel regulator of PI3K signaling and could serve to modulate thyroid tumor progression. JF - Molecular and cellular biology AU - Furuya, Fumihiko AU - Guigon, Celine J AU - Zhao, Li AU - Lu, Changxue AU - Hanover, John A AU - Cheng, Sheue-yann AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Dr., Room 5128, Bethesda, MD 20892-4264, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 6116 EP - 6126 VL - 27 IS - 17 SN - 0270-7306, 0270-7306 KW - NCOR1 protein, human KW - 0 KW - Ncor1 protein, mouse KW - Nuclear Proteins KW - Nuclear Receptor Co-Repressor 1 KW - Protein Subunits KW - RNA, Small Interfering KW - Repressor Proteins KW - Thyroid Hormone Receptors beta KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Index Medicus KW - Proto-Oncogene Proteins c-akt -- genetics KW - Animals KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Thyroid Neoplasms KW - Thyroid Gland -- pathology KW - Humans KW - Mice KW - Mice, Transgenic KW - Protein Subunits -- metabolism KW - RNA, Small Interfering -- metabolism KW - Thyroid Gland -- cytology KW - Thyroid Hormone Receptors beta -- metabolism KW - Protein Subunits -- genetics KW - Cells, Cultured KW - Gene Expression Regulation KW - Thyroid Hormone Receptors beta -- genetics KW - Signal Transduction -- physiology KW - Phosphatidylinositol 3-Kinases -- genetics KW - Nuclear Proteins -- genetics KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Repressor Proteins -- metabolism KW - Nuclear Proteins -- metabolism KW - Repressor Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68171439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Nuclear+receptor+corepressor+is+a+novel+regulator+of+phosphatidylinositol+3-kinase+signaling.&rft.au=Furuya%2C+Fumihiko%3BGuigon%2C+Celine+J%3BZhao%2C+Li%3BLu%2C+Changxue%3BHanover%2C+John+A%3BCheng%2C+Sheue-yann&rft.aulast=Furuya&rft.aufirst=Fumihiko&rft.date=2007-09-01&rft.volume=27&rft.issue=17&rft.spage=6116&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-12 N1 - Date created - 2007-08-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13209-14 [11069286] J Clin Invest. 2006 Nov;116(11):2972-84 [17039256] Cell. 2002 Jul 12;110(1):55-67 [12150997] Nature. 2002 Oct 31;419(6910):934-9 [12410313] Thyroid. 2002 Nov;12(11):963-9 [12490073] Endocr J. 2003 Feb;50(1):77-83 [12733712] Trends Endocrinol Metab. 2003 Sep;14(7):327-33 [12946875] Carcinogenesis. 2003 Sep;24(9):1467-79 [12869418] J Med Genet. 2004 Mar;41(3):161-70 [14985374] J Clin Invest. 1991 Dec;88(6):2123-30 [1661299] J Clin Invest. 1993 Oct;92(4):1986-93 [8408652] Nature. 1995 Oct 5;377(6548):397-404 [7566114] Mol Cell Biol. 2005 Jan;25(1):124-35 [15601836] Biochimie. 2005 Mar-Apr;87(3-4):287-97 [15781315] Mol Cell Biol. 2005 Sep;25(17):7687-95 [16107715] Endocrinology. 2005 Oct;146(10):4456-63 [16002527] Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16251-6 [16260719] Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1780-5 [16446424] Thyroid. 2006 Mar;16(3):211-6 [16571082] Oncogene. 2006 May 4;25(19):2736-47 [16314832] Genes Dev. 2006 Jun 1;20(11):1405-28 [16751179] Trends Cell Biol. 2006 Sep;16(9):461-6 [16870447] Cell. 2006 Oct 6;127(1):185-97 [17018285] Nat Rev Mol Cell Biol. 2002 Mar;3(3):207-14 [11994741] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Activation of cellular Arf GTPases by poliovirus protein 3CD correlates with virus replication. AN - 68168407; 17567696 AB - We have previously shown that synthesis of poliovirus protein 3CD in uninfected HeLa cell extracts induces an increased association with membranes of the cellular Arf GTPases, which are key players in cellular membrane traffic. Arfs cycle between an inactive, cytoplasmic, GDP-bound form and an active, membrane-associated, GTP-bound form. 3CD promotes binding of Arf to membranes by initiating recruitment to membranes of guanine nucleotide exchange factors (GEFs), BIG1 and BIG2. GEFs activate Arf by replacing GDP with GTP. In poliovirus-infected cells, there is a dramatic redistribution of cellular Arf pools that coincides with the reorganization of membranes used to form viral RNA replication complexes. Here we demonstrate that Arf translocation in vitro can be induced by purified recombinant 3CD protein; thus, concurrent translation of viral RNA is not required. Coexpression of 3C and 3D proteins was not sufficient to target Arf to membranes. 3CD expressed in HeLa cells was retained after treatment of the cells with digitonin, indicating that it may interact with a membrane-bound host factor. A F441S mutant of 3CD was shown previously to have lost Arf translocation activity and was also defective in attracting the corresponding GEFs to membranes. A series of other mutations were introduced at 3CD residue F441. Mutations that retained Arf translocation activity of 3CD also supported efficient growth of virus, regardless of their effects on 3D polymerase elongation activity. Those that abrogated Arf activation by 3CD generated quasi-infectious RNAs that produced some plaques from which revertants that always restored the Arf activation property of 3CD were rescued. JF - Journal of virology AU - Belov, George A AU - Habbersett, Courtney AU - Franco, David AU - Ehrenfeld, Ellie AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8011, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 9259 EP - 9267 VL - 81 IS - 17 SN - 0022-538X, 0022-538X KW - Viral Proteins KW - 0 KW - Cysteine Endopeptidases KW - EC 3.4.22.- KW - 3C proteases KW - EC 3.4.22.28 KW - ADP-Ribosylation Factors KW - EC 3.6.5.2 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Microscopy, Fluorescence KW - Viral Plaque Assay KW - HeLa Cells KW - Amino Acid Substitution -- genetics KW - Humans KW - Cell Membrane -- chemistry KW - Protein Transport KW - Virus Replication KW - Viral Proteins -- genetics KW - Poliovirus -- growth & development KW - ADP-Ribosylation Factors -- metabolism KW - Cysteine Endopeptidases -- metabolism KW - Poliovirus -- metabolism KW - Poliovirus -- genetics KW - Viral Proteins -- metabolism KW - Cysteine Endopeptidases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68168407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Activation+of+cellular+Arf+GTPases+by+poliovirus+protein+3CD+correlates+with+virus+replication.&rft.au=Belov%2C+George+A%3BHabbersett%2C+Courtney%3BFranco%2C+David%3BEhrenfeld%2C+Ellie&rft.aulast=Belov&rft.aufirst=George&rft.date=2007-09-01&rft.volume=81&rft.issue=17&rft.spage=9259&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-28 N1 - Date created - 2007-08-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 2000 Mar;74(5):2219-26 [10666252] J Virol. 2007 May;81(10):5238-45 [17329336] J Virol. 2000 Nov;74(22):10359-70 [11044080] J Virol. 2001 Sep;75(17):8158-65 [11483761] J Cell Sci. 2001 Oct;114(Pt 19):3413-8 [11682601] J Virol. 2002 Mar;76(5):2529-42 [11836431] Arch Virol. 2002 Apr;147(4):731-44 [12038684] Curr Opin Cell Biol. 2003 Aug;15(4):396-404 [12892779] J Virol. 2003 Nov;77(21):11408-16 [14557626] Virology. 2004 Mar 15;320(2):195-205 [15016543] J Biol Chem. 2004 Mar 26;279(13):12659-67 [14711816] EMBO J. 2004 Sep 1;23(17):3462-71 [15306852] Virology. 1988 Sep;166(1):265-70 [2842953] Science. 1991 Dec 13;254(5038):1647-51 [1661029] J Virol. 1992 Apr;66(4):1985-94 [1312615] J Cell Biol. 1992 Dec;119(5):1097-116 [1447290] EMBO J. 1993 Sep;12(9):3587-98 [8253083] Arch Virol Suppl. 1994;9:159-72 [8032247] J Biol Chem. 1994 Oct 28;269(43):27015-20 [7929442] J Virol. 1994 Nov;68(11):7507-15 [7933134] J Virol. 1995 Jun;69(6):3658-67 [7745714] Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2296-301 [8637866] J Virol. 1997 Jan;71(1):578-85 [8985386] Biochemistry. 1997 Apr 15;36(15):4675-84 [9109679] RNA. 1997 Oct;3(10):1124-34 [9326487] J Mol Biol. 1997 Nov 14;273(5):1032-47 [9367789] J Virol. 1997 Dec;71(12):8962-72 [9371552] J Virol. 1997 Dec;71(12):9054-64 [9371562] J Virol. 1998 Aug;72(8):6456-64 [9658088] Genes Dev. 1998 Aug 1;12(15):2293-304 [9694795] J Cell Biol. 1999 Jul 12;146(1):71-84 [10402461] J Virol. 2005 Mar;79(6):3254-66 [15731220] J Virol. 2005 May;79(10):6358-67 [15858019] J Virol. 2005 Jun;79(11):7207-16 [15890959] Virology. 2005 Jun 20;337(1):18-29 [15914217] Nature. 2005 Dec 1;438(7068):597-604 [16319879] Nat Rev Mol Cell Biol. 2006 May;7(5):347-58 [16633337] J Virol. 2006 Jul;80(13):6637-47 [16775351] Dev Cell. 2006 Aug;11(2):191-201 [16890159] J Virol. 2006 Dec;80(23):11852-60 [17005635] J Virol. 2007 Jan;81(2):558-67 [17079330] Cell Cycle. 2007 Jan 1;6(1):36-8 [17245115] J Virol. 2007 Apr;81(7):3583-96 [17251299] Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2567-72 [10716990] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Vpr cytopathicity independent of G2/M cell cycle arrest in human immunodeficiency virus type 1-infected CD4+ T cells. AN - 68168354; 17553871 AB - The mechanism of CD4(+) T-cell depletion in human immunodeficiency virus type 1 (HIV-1)-infected individuals remains unknown, although mounting evidence suggests that direct viral cytopathicity contributes to this loss. The HIV-1 Vpr accessory protein causes cell death and arrests cells in the G(2)/M phase; however, the molecular mechanism underlying these properties is not clear. Mutation of hydrophobic residues on the surface of its third alpha-helix disrupted Vpr toxicity, G(2)/M arrest induction, nuclear localization, and self-association, implicating this region in multiple Vpr functions. Cytopathicity by virion-delivered mutant Vpr protein correlated with G(2)/M arrest induction but not nuclear localization or self-association. However, infection with whole virus encoding these Vpr mutants did not abrogate HIV-1-induced cell killing. Rather, mutant Vpr proteins that are impaired for G(2)/M block still prevented infected cell proliferation, and this property correlated with the death of infected cells. Chemical agents that inhibit infected cells from entering G(2)/M also did not reduce HIV-1 cytopathicity. Combined, these data implicate Vpr in HIV-1 killing through a mechanism involving inhibiting cell division but not necessarily in G(2)/M. Thus, the hydrophobic region of the third alpha-helix of Vpr is crucial for mediating G(2)/M arrest, nuclear localization, and self-association but dispensable for HIV-1 cytopathicity due to residual cell proliferation blockade mediated by a separate region of the protein. JF - Journal of virology AU - Bolton, Diane L AU - Lenardo, Michael J AD - Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg. 10, Rm. 11N311, 10 Center Dr., Bethesda, MD 20892-1892, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 8878 EP - 8890 VL - 81 IS - 17 SN - 0022-538X, 0022-538X KW - Gene Products, vpr KW - 0 KW - vpr Gene Products, Human Immunodeficiency Virus KW - Index Medicus KW - Hydrophobic and Hydrophilic Interactions KW - Protein Structure, Secondary KW - Models, Molecular KW - Humans KW - Jurkat Cells KW - Cell Line, Tumor KW - Mutation, Missense KW - Mutagenesis, Site-Directed KW - Protein Transport -- genetics KW - Amino Acid Substitution -- genetics KW - Cell Death KW - Protein Binding -- genetics KW - CD4-Positive T-Lymphocytes -- cytology KW - HIV-1 -- pathogenicity KW - CD4-Positive T-Lymphocytes -- virology KW - Gene Products, vpr -- chemistry KW - Gene Products, vpr -- physiology KW - Cytopathogenic Effect, Viral KW - Cell Cycle KW - Gene Products, vpr -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68168354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Resistance+to+Chronic+Wasting+Disease+in+Transgenic+Mice+Expressing+a+Naturally+Occurring+Allelic+Variant+of+Deer+Prion+Protein&rft.au=Meade-White%2C+Kimberly%3BRace%2C+Brent%3BTrifilo%2C+Matthew%3BBossers%2C+Alex%3BFavara%2C+Cynthia%3BLacasse%2C+Rachel%3BMiller%2C+Michael%3BWilliams%2C+Elizabeth%3BOldstone%2C+Michael%3BRace%2C+Richard%3BChesebro%2C+Bruce&rft.aulast=Meade-White&rft.aufirst=Kimberly&rft.date=2007-05-01&rft.volume=81&rft.issue=9&rft.spage=4533&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-28 N1 - Date created - 2007-08-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 2005 Mar;79(5):2780-7 [15708996] Microbes Infect. 2000 Jul;2(9):1011-7 [10967282] Virology. 2000 Oct 10;276(1):16-26 [11021990] J Biol Chem. 2000 Oct 13;275(41):32016-26 [10903315] J Virol. 2001 Apr;75(8):3791-801 [11264368] Nat Immunol. 2000 Oct;1(4):285-9 [11017098] Nature. 2001 Apr 19;410(6831):974-9 [11309627] Science. 2001 Nov 2;294(5544):1105-8 [11691994] Sci STKE. 2000 Jun 27;2000(38):pl1 [11752595] J Virol. 2002 May;76(10):5082-93 [11967324] J Virol. 2002 May;76(10):5094-107 [11967325] Arch Virol. 1991;120(3-4):181-92 [1835572] Virology. 1991 Dec;185(2):829-39 [1683728] J Virol. 1993 Nov;67(11):6542-50 [8411357] J Virol. 1993 Dec;67(12):7229-37 [8230445] Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7311-5 [8041786] J Biol Chem. 1994 Dec 23;269(51):32131-7 [7798208] J Virol. 1995 Feb;69(2):882-8 [7815556] Nature. 1995 Jan 12;373(6510):117-22 [7529365] Nature. 1995 Jan 12;373(6510):123-6 [7816094] J Virol. 1995 Apr;69(4):2378-83 [7884883] J Virol. 1995 Oct;69(10):6304-13 [7666531] J Virol. 1995 Nov;69(11):6705-11 [7474080] J Virol. 1995 Nov;69(11):6859-64 [7474100] J Biol Chem. 1995 Oct 27;270(43):25564-9 [7592727] J Virol. 1995 Dec;69(12):7507-18 [7494257] J Virol. 1995 Dec;69(12):7909-16 [7494303] J Virol. 1996 Apr;70(4):2324-31 [8642659] J Virol. 1996 Mar;70(3):1340-54 [8627650] Drug Resist Updat. 2001 Oct;4(5):303-13 [11991684] J Mol Biol. 2003 Mar 14;327(1):215-27 [12614620] Mol Biol Cell. 2004 Apr;15(4):1793-801 [14767062] Cell. 2004 Aug 20;118(4):493-504 [15315761] Science. 2005 Mar 4;307(5714):1465-8 [15746428] Biochem J. 2005 Apr 15;387(Pt 2):333-41 [15571493] Nature. 2005 Apr 28;434(7037):1093-7 [15793563] Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3369-74 [16492778] AIDS. 2006 Apr 4;20(6):831-6 [16549966] Microbes Infect. 2006 Mar;8(3):670-9 [16480911] PLoS Pathog. 2006 Dec;2(12):e127 [17140287] Nat Cell Biol. 1999 May;1(1):60-7 [10559866] J Biol Chem. 2000 Apr 28;275(17):12661-6 [10777558] J Virol. 2000 Jul;74(14):6520-7 [10864665] Exp Cell Res. 2000 Aug 1;258(2):261-9 [10896777] J Exp Med. 2004 Sep 20;200(6):749-59 [15365096] J Biol Chem. 2004 Oct 1;279(40):41801-6 [15294906] J Clin Invest. 1991 May;87(5):1710-5 [2022741] J Mol Biol. 1996 Sep 6;261(5):599-606 [8800208] Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11382-8 [8876144] Biochem Biophys Res Commun. 1997 Mar 17;232(2):550-4 [9125220] J Virol. 1997 May;71(5):3961-71 [9094673] Science. 1997 May 9;276(5314):960-4 [9139661] J Virol. 1997 Jun;71(6):4331-8 [9151821] J Virol. 1997 Jul;71(7):5579-92 [9188632] AIDS. 1997 Aug;11(10):1219-25 [9256939] J Virol. 1997 Sep;71(9):6339-47 [9261351] Cell Biochem Funct. 1997 Sep;15(3):171-9 [9377795] J Virol. 1998 Jan;72(1):660-70 [9420271] Nat Med. 1998 Jan;4(1):65-71 [9427608] Genes Dev. 1998 Jan 15;12(2):175-85 [9436978] Virology. 1998 Jan 20;240(2):232-7 [9454696] J Exp Med. 1998 Feb 2;187(3):403-13 [9449720] EMBO J. 1998 Feb 16;17(4):909-17 [9463369] J Biol Chem. 1998 Apr 3;273(14):8130-6 [9525916] Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5281-6 [9560267] J Virol. 1998 Jun;72(6):4686-93 [9573232] FEBS Lett. 1998 Jul 31;432(1-2):17-20 [9710242] J Virol. 1998 Nov;72(11):8873-83 [9765432] J Mol Biol. 1999 Feb 5;285(5):2105-17 [9925788] J Virol. 1999 Apr;73(4):3236-45 [10074177] Biochem Biophys Res Commun. 1999 May 10;258(2):379-84 [10329395] Annu Rev Immunol. 1999;17:625-56 [10358770] J Virol. 1999 Jul;73(7):5422-30 [10364289] Cancer Res. 1999 Sep 1;59(17):4375-82 [10485486] Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):12039-43 [10518572] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Erythrocebus patas monkey offspring exposed perinatally to NRTIs sustain skeletal muscle mitochondrial compromise at birth and at 1 year of age. AN - 68158514; 17545213 AB - Antiretroviral nucleoside reverse transcriptase inhibitors (NRTIs), given to human immunodeficiency virus-1-infected pregnant women to prevent vertical viral transmission, have caused mitochondrial dysfunction in some human infants. Here, we examined mitochondrial integrity in skeletal muscle from offspring of pregnant retroviral-free Erythrocebus patas dams administered human-equivalent NRTI doses for the last 10 weeks of gestation or for 10 weeks of gestation and 6 weeks after birth. Exposures included no drug, Zidovudine (AZT), Lamivudine (3TC), AZT/3TC, AZT/Didanosine (ddI), and Stavudine (d4T)/3TC. Offspring were examined at birth (n=3 per group) and 1 year (n=4 per group, not including 3TC alone). Circulating levels of creatine kinase were elevated at 1 year in the d4T/3TC-exposed group. Measurement of oxidative phosphorylation enzyme activities (complexes I, II, and IV) revealed minimal NRTI-induced changes at birth and at 1 year. Histochemistry for complex IV activity showed abnormal staining with activity depletion at birth and 1 year in groups exposed to AZT alone and to the 2-NRTI combinations. Electron microscopy of skeletal muscle at birth and 1 year of age showed mild to severe mitochondrial damage in all the NRTI-exposed groups, with 3TC inducing mild damage and the 2-NRTI combinations inducing extensive damage. At birth, mitochondrial DNA (mtDNA) was depleted by approximately 50% in groups exposed to AZT alone and the 2-NRTI combinations. At 1 year, the mtDNA levels had increased but remained significantly below normal. Therefore, skeletal muscle mitochondrial compromise occurs at birth and persists at 1 year of age (46 weeks after the last NRTI exposure) in perinatally exposed young monkeys, suggesting that similar events may occur in NRTI-exposed human infants. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Divi, Rao L AU - Leonard, Sarah L AU - Walker, Brettania L AU - Kuo, Maryanne M AU - Shockley, Marie E AU - St Claire, Marisa C AU - Nagashima, Kunio AU - Harbaugh, Steven W AU - Harbaugh, Jeffrey W AU - Poirier, Miriam C AD - Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, Maryland 20892-4255, USA. divir@exchange.nih.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 203 EP - 213 VL - 99 IS - 1 SN - 1096-6080, 1096-6080 KW - Anti-HIV Agents KW - 0 KW - DNA, Mitochondrial KW - Multienzyme Complexes KW - Reverse Transcriptase Inhibitors KW - Creatine Kinase KW - EC 2.7.3.2 KW - Index Medicus KW - Drug Therapy, Combination KW - Multienzyme Complexes -- metabolism KW - Microscopy, Electron, Transmission KW - Animals, Newborn KW - Animals KW - DNA, Mitochondrial -- drug effects KW - Gestational Age KW - DNA, Mitochondrial -- analysis KW - Creatine Kinase -- metabolism KW - Histocytochemistry KW - Erythrocebus patas KW - Female KW - Pregnancy KW - Maternal Exposure -- adverse effects KW - Anti-HIV Agents -- toxicity KW - Muscle, Skeletal -- ultrastructure KW - Mitochondria, Muscle -- ultrastructure KW - Mitochondria, Muscle -- genetics KW - Reverse Transcriptase Inhibitors -- toxicity KW - Muscle, Skeletal -- enzymology KW - Muscle, Skeletal -- drug effects KW - Mitochondria, Muscle -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68158514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Erythrocebus+patas+monkey+offspring+exposed+perinatally+to+NRTIs+sustain+skeletal+muscle+mitochondrial+compromise+at+birth+and+at+1+year+of+age.&rft.au=Divi%2C+Rao+L%3BLeonard%2C+Sarah+L%3BWalker%2C+Brettania+L%3BKuo%2C+Maryanne+M%3BShockley%2C+Marie+E%3BSt+Claire%2C+Marisa+C%3BNagashima%2C+Kunio%3BHarbaugh%2C+Steven+W%3BHarbaugh%2C+Jeffrey+W%3BPoirier%2C+Miriam+C&rft.aulast=Divi&rft.aufirst=Rao&rft.date=2007-09-01&rft.volume=99&rft.issue=1&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-04 N1 - Date created - 2007-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A review of the interaction among dietary antioxidants and reactive oxygen species. AN - 68156637; 17360173 AB - During normal cellular activities, various processes inside of cells produce reactive oxygen species (ROS). Some of the most common ROS are hydrogen peroxide (H(2)O(2)), superoxide ion (O(2)(-)), and hydroxide radical (OH(-)). These compounds, when present in a high enough concentration, can damage cellular proteins and lipids or form DNA adducts that may promote carcinogenic activity. The purpose of antioxidants in a physiological setting is to prevent ROS concentrations from reaching a high-enough level within a cell that damage may occur. Cellular antioxidants may be enzymatic (catalase, glutathione peroxidase, superoxide dismutase) or nonenzymatic (glutathione, thiols, some vitamins and metals, or phytochemicals such as isoflavones, polyphenols, and flavanoids). Reactive oxygen species are a potential double-edged sword in disease prevention and promotion. Whereas generation of ROS once was viewed as detrimental to the overall health of the organism, advances in research have shown that ROS play crucial roles in normal physiological processes including response to growth factors, the immune response, and apoptotic elimination of damaged cells. Notwithstanding these beneficial functions, aberrant production or regulation of ROS activity has been demonstrated to contribute to the development of some prevalent diseases and conditions, including cancer and cardiovascular disease (CVD). The topic of antioxidant usage and ROS is currently receiving much attention because of studies linking the use of some antioxidants with increased mortality in primarily higher-risk populations and the lack of strong efficacy data for protection against cancer and heart disease, at least in populations with adequate baseline dietary consumption. In normal physiological processes, antioxidants effect signal transduction and regulation of proliferation and the immune response. Reactive oxygen species have been linked to cancer and CVD, and antioxidants have been considered promising therapy for prevention and treatment of these diseases, especially given the tantalizing links observed between diets high in fruits and vegetables (and presumably antioxidants) and decreased risks for cancer. JF - The Journal of nutritional biochemistry AU - Seifried, Harold E AU - Anderson, Darrell E AU - Fisher, Evan I AU - Milner, John A AD - Division of Cancer Prevention, National Cancer Institute, Rockville, MD 20862, USA. hs41s@nih.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 567 EP - 579 VL - 18 IS - 9 SN - 0955-2863, 0955-2863 KW - Antioxidants KW - 0 KW - Reactive Oxygen Species KW - Index Medicus KW - Animals KW - Humans KW - Diet KW - Models, Biological KW - Signal Transduction KW - Reactive Oxygen Species -- metabolism KW - Neoplasms -- drug therapy KW - Antioxidants -- therapeutic use KW - Cardiovascular Diseases -- metabolism KW - Cardiovascular Diseases -- drug therapy KW - Neoplasms -- prevention & control KW - Cardiovascular Diseases -- prevention & control KW - Neoplasms -- metabolism KW - Antioxidants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68156637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nutritional+biochemistry&rft.atitle=A+review+of+the+interaction+among+dietary+antioxidants+and+reactive+oxygen+species.&rft.au=Seifried%2C+Harold+E%3BAnderson%2C+Darrell+E%3BFisher%2C+Evan+I%3BMilner%2C+John+A&rft.aulast=Seifried&rft.aufirst=Harold&rft.date=2007-09-01&rft.volume=18&rft.issue=9&rft.spage=567&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nutritional+biochemistry&rft.issn=09552863&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-27 N1 - Date created - 2007-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The putative tumor suppressor Tsc-22 is downregulated early in chemically induced hepatocarcinogenesis and may be a suppressor of Gadd45b. AN - 68155841; 17533171 AB - Tsc-22 is a novel tumor suppressor gene that represents a new class of transcription factors that has transcriptional repressor activity. We found Tsc-22 downregulation in livers from B6C3F1 mice following treatment for 2 weeks with carcinogenic doses of the antianxiety drug oxazepam (2500 ppm) or the peroxisome proliferator Wyeth-14,643 (500 ppm) but not with two other carcinogens such as o-nitrotoluene or methyleugenol or three noncarcinogens including p-nitrotoluene, eugenol, or acetaminophen. The expression of Tsc-22 was also repressed in B6C3F1 mouse liver tumors that were induced by several chemicals from 2-year carcinogenicity studies as well as in spontaneous liver tumors. To identify potential Tsc-22 target genes in mouse liver, we transfected small interference RNA (SiRNA) designed to inhibit Tsc-22 into murine liver BNL-CL.2 cells. We selected two potential transcriptional targets of Tsc-22, growth arrest and DNA damage-inducible gene 45 beta (Gadd45b) and leucine zipper, putative tumor suppressor 2 (Lzts2) to test based on our previous complementary DNA microarray studies, showing that expression of these cancer-associated genes was increased when Tsc-22 was repressed. SiRNA treatment of BNL-CL.2 cells with Tsc-22 oligonucleotides but not nonspecific oligonucleotides decreased RNA and protein expression of Tsc-22 by 80-90%, while expression of Gadd45b gene, but not Lzts2, was increased over time after an initial decrease. Treatment of these cells with oxazepam for 48 h also resulted in decreased Tsc-22 and increased Gadd45b expression. These data provide evidence that Tsc-22 is a suppressor of Gadd45b expression, which may contribute to an early antiapoptotic response. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Iida, Mari AU - Anna, Colleen H AU - Gaskin, Nicole D AU - Walker, Nigel J AU - Devereux, Theodora R AD - Laboratory of Molecular Carcinogenesis, Toxicology Operations Branch, Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, USA. kotorogzo@yahoo.co.jp Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 43 EP - 50 VL - 99 IS - 1 SN - 1096-6080, 1096-6080 KW - Antigens, Differentiation KW - 0 KW - Carcinogens KW - Gadd45b protein, mouse KW - RNA, Small Interfering KW - Repressor Proteins KW - Tgfb1i4 protein, mouse KW - Transforming Growth Factor beta1 KW - Tumor Suppressor Proteins KW - Oxazepam KW - 6GOW6DWN2A KW - Index Medicus KW - Animals KW - Oligonucleotide Array Sequence Analysis KW - Oxazepam -- pharmacology KW - Tumor Suppressor Proteins -- genetics KW - Liver -- metabolism KW - Cell Line, Tumor KW - Mice KW - Gene Expression Profiling KW - Mice, Inbred Strains KW - Down-Regulation KW - Liver -- drug effects KW - Tumor Suppressor Proteins -- metabolism KW - RNA, Small Interfering -- pharmacology KW - Transforming Growth Factor beta1 -- pharmacology KW - Female KW - Male KW - Liver Neoplasms, Experimental -- genetics KW - Genes, Tumor Suppressor -- drug effects KW - Antigens, Differentiation -- metabolism KW - Repressor Proteins -- metabolism KW - Carcinogens -- toxicity KW - Antigens, Differentiation -- genetics KW - Liver Neoplasms, Experimental -- chemically induced KW - Repressor Proteins -- genetics KW - Repressor Proteins -- antagonists & inhibitors KW - Gene Expression Regulation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68155841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=The+putative+tumor+suppressor+Tsc-22+is+downregulated+early+in+chemically+induced+hepatocarcinogenesis+and+may+be+a+suppressor+of+Gadd45b.&rft.au=Iida%2C+Mari%3BAnna%2C+Colleen+H%3BGaskin%2C+Nicole+D%3BWalker%2C+Nigel+J%3BDevereux%2C+Theodora+R&rft.aulast=Iida&rft.aufirst=Mari&rft.date=2007-09-01&rft.volume=99&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-04 N1 - Date created - 2007-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toward a checklist for exchange and interpretation of data from a toxicology study. AN - 68155237; 17442663 AB - Data from toxicology and toxicogenomics studies are valuable, and can be combined for meta-analysis using public data repositories such as Chemical Effects in Biological Systems Knowledgebase, ArrayExpress, and Gene Expression Omnibus. In order to fully utilize the data for secondary analysis, it is necessary to have a description of the study and good annotation of the accompanying data. This study annotation permits sophisticated cross-study comparison and analysis, and allows data from comparable subjects to be identified and fully understood. The Minimal Information About a Microarray Experiment Standard was proposed to permit deposition and sharing of microarray data. We propose the first step toward an analogous standard for a toxicogenomics/toxicology study, by describing a checklist of information that best practices would suggest be included with the study data. When the information in this checklist is deposited together with the study data, the checklist information helps the public explore the study data in context of time, or identify data from similarly treated subjects, and also explore/identify potential sources of experimental variability. The proposed checklist summarizes useful information to include when sharing study data for publication, deposition into a database, or electronic exchange with collaborators. It is not a description of how to carry out an experiment, but a definition of how to describe an experiment. It is anticipated that once a toxicology checklist is accepted and put into use, then toxicology databases can be configured to require and output these fields, making it straightforward to annotate data for interpretation by others. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Fostel, Jennifer M AU - Burgoon, Lyle AU - Zwickl, Craig AU - Lord, Peter AU - Corton, J Christopher AU - Bushel, Pierre R AU - Cunningham, Michael AU - Fan, Liju AU - Edwards, Stephen W AU - Hester, Susan AU - Stevens, James AU - Tong, Weida AU - Waters, Michael AU - Yang, ChiHae AU - Tennant, Raymond AD - NIEHS, LMIT ITSS Contract, Research Triangle Park, North Carolina 27709-2233, USA. fostel@niehs.nih.gov Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 26 EP - 34 VL - 99 IS - 1 SN - 1096-6080, 1096-6080 KW - Index Medicus KW - Software KW - Animals KW - Oligonucleotide Array Sequence Analysis -- methods KW - Data Display KW - Data Collection KW - Oligonucleotide Array Sequence Analysis -- statistics & numerical data KW - Meta-Analysis as Topic KW - Toxicity Tests -- statistics & numerical data KW - Toxicity Tests -- methods KW - Data Interpretation, Statistical KW - Databases, Genetic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68155237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Toward+a+checklist+for+exchange+and+interpretation+of+data+from+a+toxicology+study.&rft.au=Fostel%2C+Jennifer+M%3BBurgoon%2C+Lyle%3BZwickl%2C+Craig%3BLord%2C+Peter%3BCorton%2C+J+Christopher%3BBushel%2C+Pierre+R%3BCunningham%2C+Michael%3BFan%2C+Liju%3BEdwards%2C+Stephen+W%3BHester%2C+Susan%3BStevens%2C+James%3BTong%2C+Weida%3BWaters%2C+Michael%3BYang%2C+ChiHae%3BTennant%2C+Raymond&rft.aulast=Fostel&rft.aufirst=Jennifer&rft.date=2007-09-01&rft.volume=99&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-04 N1 - Date created - 2007-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Targeting Akt in cancer therapy. AN - 68122231; 17667591 AB - In an effort to improve therapeutic options in cancer, many investigational drugs are being developed to inhibit signaling pathways that promote the survival of cancer cells. The prototypic pathway that promotes cellular survival is the phosphoinositide 3'-kinase/Akt/mammalian target of rapamycin pathway, which is constitutively activated in many types of cancers. Mechanisms for activation of the serine/threonine kinase, Akt, include loss of tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10) function, amplification or mutation of phosphoinositide 3'-kinase, amplification of Akt, activation of growth factor receptors and exposure to carcinogens. Activation of Akt promotes cellular survival as well as resistance to treatment with chemotherapy and/or radiation therapy. Immunohistochemical analyses have shown that Akt is activated in many types of cancers and preneoplastic lesions, and Akt activation is a poor prognostic factor in various cancers. Taken together, these data demonstrate that Akt is a valid target for inhibition. This review will focus on published data using different approaches to inhibit Akt. We will also consider how the complex regulation of the phosphoinositide 3'-kinase/Akt/mammalian target of rapamycin pathway poses practical issues concerning the design of clinical trials, potential toxicities and the likelihood of finding a therapeutic index when targeting such a critical cellular pathway. JF - Anti-cancer drugs AU - LoPiccolo, Jaclyn AU - Granville, Courtney A AU - Gills, Joell J AU - Dennis, Phillip A AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 861 EP - 874 VL - 18 IS - 8 SN - 0959-4973, 0959-4973 KW - Antineoplastic Agents KW - 0 KW - Lipids KW - Peptides KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Index Medicus KW - Animals KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Lipids -- chemistry KW - Adenosine Triphosphate -- antagonists & inhibitors KW - Humans KW - Signal Transduction -- drug effects KW - Lipids -- pharmacology KW - Peptides -- pharmacology KW - Drug Design KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Proto-Oncogene Proteins c-akt -- drug effects KW - Proto-Oncogene Proteins c-akt -- antagonists & inhibitors KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68122231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anti-cancer+drugs&rft.atitle=Targeting+Akt+in+cancer+therapy.&rft.au=LoPiccolo%2C+Jaclyn%3BGranville%2C+Courtney+A%3BGills%2C+Joell+J%3BDennis%2C+Phillip+A&rft.aulast=LoPiccolo&rft.aufirst=Jaclyn&rft.date=2007-09-01&rft.volume=18&rft.issue=8&rft.spage=861&rft.isbn=&rft.btitle=&rft.title=Anti-cancer+drugs&rft.issn=09594973&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-28 N1 - Date created - 2007-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - CYP2D6 polymorphisms and the impact on tamoxifen therapy. AN - 68119728; 17518364 AB - The cytochrome P450 2D6 (CYP2D6) is an enzyme known to metabolize a variety of xenobiotics and drugs. Inter-individual variation in the metabolic capacity of this enzyme has been extensively studied and associations with genotype have been established. Genetic polymorphisms have been grouped as nonfunctional, reduced function, functional, and multiplication alleles phenotypically. Individuals carrying these alleles are presumed to correspond to poor, intermediate, extensive, and ultrarapid metabolizers (UM), respectively. Tamoxifen has been shown to be metabolized by CYP2D6 to the more potent metabolite endoxifen. Poor metabolizers (PM) of tamoxifen have lower levels of endoxifen and poorer clinical outcomes as compared to extensive metabolizers (EM). Here, we will provide an overview of the history and application of CYP2D6 pharmacogenetics, and will discuss the clinical implications of recent developments relating to the involvement of CYP2D6 in tamoxifen treatment. (c) 2007 Wiley-Liss, Inc. and the American Pharmacists Association. JF - Journal of pharmaceutical sciences AU - Beverage, Jacob N AU - Sissung, Tristan M AU - Sion, Amy M AU - Danesi, Romano AU - Figg, William D AD - Clinical Pharmacology Research Core, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Building 10, Room 5A01, Bethesda, Maryland, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 2224 EP - 2231 VL - 96 IS - 9 SN - 0022-3549, 0022-3549 KW - Antineoplastic Agents, Hormonal KW - 0 KW - Tamoxifen KW - 094ZI81Y45 KW - Cytochrome P-450 CYP2D6 KW - EC 1.14.14.1 KW - Index Medicus KW - Phenotype KW - Animals KW - Polymorphism, Genetic KW - Humans KW - Cytochrome P-450 CYP2D6 -- genetics KW - Neoplasms -- drug therapy KW - Neoplasms -- enzymology KW - Tamoxifen -- therapeutic use KW - Tamoxifen -- adverse effects KW - Antineoplastic Agents, Hormonal -- therapeutic use KW - Antineoplastic Agents, Hormonal -- adverse effects KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68119728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pharmaceutical+sciences&rft.atitle=CYP2D6+polymorphisms+and+the+impact+on+tamoxifen+therapy.&rft.au=Beverage%2C+Jacob+N%3BSissung%2C+Tristan+M%3BSion%2C+Amy+M%3BDanesi%2C+Romano%3BFigg%2C+William+D&rft.aulast=Beverage&rft.aufirst=Jacob&rft.date=2007-09-01&rft.volume=96&rft.issue=9&rft.spage=2224&rft.isbn=&rft.btitle=&rft.title=Journal+of+pharmaceutical+sciences&rft.issn=00223549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-27 N1 - Date created - 2007-08-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - New immunotoxins targeting CD123, a stem cell antigen on acute myeloid leukemia cells. AN - 68109906; 17667524 AB - The specific alpha subunit of the interleukin-3 receptor (IL-3Ralpha, CD123) is strongly expressed in various leukemic blasts and leukemic stem cells and seems to be an excellent target for the therapy of leukemias. In this study, immunotoxins were developed to target CD123 only, which bypasses the dependence on other subunits to form intact IL-3R. Three anti-CD123 hybridomas (26292, 32701, and 32716) were selected on the basis of their affinity for CD123. Total RNAs were extracted from the 3 anti-CD123 hybridomas and used to clone the fragment of variable region (Fvs). The Fvs were assembled into single chain Fvs and fused to a 38-kd fragment of Pseudomonas exotoxin A to make recombinant immunotoxins. 26292(Fv)-PE38 was found to have the highest cytotoxic activity on the CD123 expressing leukemia cell line TF-1. It bound the cells with a kd of 3.5 nM. Another immunotoxin, 32716(Fv)-PE38, belonging to a different epitope group, had a similar binding ability but was less active, demonstrating the role of epitope selection in immunotoxin action. The cytotoxic activity of 26292(Fv)-PE38 was increased from 200 to about 40 ng/mL by mutating the REDLK sequence at the C terminus to KDEL. 26292(Fv)-PE38-KDEL was specifically cytotoxic to several CD123 expressing cell lines (TF-1, Molm-13, and Molm-14) with good CD123 expression but not to ML-1 or U937 with low or absent expression. In conclusion, 26292(Fv)-PE38-KDEL shows good cytotoxic activity against CD123 expressing cell lines, and merits further development for the possible treatment of acute myeloid leukemia and other CD123 expressing malignancies. JF - Journal of immunotherapy (Hagerstown, Md. : 1997) AU - Du, Xing AU - Ho, Mitchell AU - Pastan, Ira AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA. Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 607 EP - 613 VL - 30 IS - 6 SN - 1524-9557, 1524-9557 KW - Antibodies, Monoclonal KW - 0 KW - Bacterial Toxins KW - Exotoxins KW - IL3RA protein, human KW - Immunoglobulin Fragments KW - Immunoglobulin Variable Region KW - Immunotoxins KW - Interleukin-3 Receptor alpha Subunit KW - Receptors, Interleukin-3 KW - Recombinant Fusion Proteins KW - Virulence Factors KW - ADP Ribose Transferases KW - EC 2.4.2.- KW - toxA protein, Pseudomonas aeruginosa KW - EC 2.4.2.31 KW - Index Medicus KW - Acute Disease KW - Antibodies, Monoclonal -- metabolism KW - Humans KW - Immunoglobulin Fragments -- metabolism KW - Cell Line, Tumor KW - Immunoglobulin Fragments -- immunology KW - Antibodies, Monoclonal -- therapeutic use KW - Antibodies, Monoclonal -- immunology KW - ADP Ribose Transferases -- immunology KW - Leukemia, Myeloid -- immunology KW - Virulence Factors -- therapeutic use KW - Interleukin-3 Receptor alpha Subunit -- metabolism KW - Leukemia, Myeloid -- therapy KW - Receptors, Interleukin-3 -- immunology KW - Bacterial Toxins -- immunology KW - Exotoxins -- immunology KW - Immunotoxins -- metabolism KW - Virulence Factors -- immunology KW - ADP Ribose Transferases -- therapeutic use KW - Bacterial Toxins -- metabolism KW - Receptors, Interleukin-3 -- metabolism KW - Virulence Factors -- metabolism KW - Immunotoxins -- immunology KW - Interleukin-3 Receptor alpha Subunit -- immunology KW - Bacterial Toxins -- therapeutic use KW - Leukemia, Myeloid -- metabolism KW - ADP Ribose Transferases -- metabolism KW - Exotoxins -- metabolism KW - Immunotoxins -- therapeutic use KW - Exotoxins -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68109906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.atitle=New+immunotoxins+targeting+CD123%2C+a+stem+cell+antigen+on+acute+myeloid+leukemia+cells.&rft.au=Du%2C+Xing%3BHo%2C+Mitchell%3BPastan%2C+Ira&rft.aulast=Du&rft.aufirst=Xing&rft.date=2007-09-01&rft.volume=30&rft.issue=6&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.issn=15249557&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-24 N1 - Date created - 2007-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of Individual Components of Multiple Behavior Changes: The PREMIER Trial AN - 57223526; 200804832 AB - Objectives: To assess contributions of individual lifestyle changes on systolic blood pressure (SBP) changes. Methods: We examined associations between lifestyle behavior changes and SBP after 6 and 18 months in 782 PREMIER trial participants. Results: In multivariate models omitting weight, predicted SBP reductions ranged from 1/2 to 1 1/2 mm Hg for reduced urinary sodium, improved fitness, and adherence to the DASH diet (except sodium at 18 months). With weight included, only fitness change additionally predicted SBP at 18 months. Conclusions: Several lifestyle behavior changes are important for BP lowering, but are difficult to detect when weight is included in multivariate models. Adapted from the source document. JF - American Journal of Health Behavior AU - Obarzanek, Eva AU - Vollmer, William M AU - Lin, Pao-Hwa AU - Cooper, Lawton S AU - Young, Deborah R AU - Ard, Jamy D AU - Stevens, Victor J AU - Simons-Morton, Denise G AU - Svetkey, Laura P AU - Harsha, David W AU - Elmer, Patricia J AU - Appel, Lawrence J AD - National Heart, Lung, and Blood Institute, 6701 Rockledge Drive, Bethesda MD 20892-7936 Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 545 EP - 560 PB - PNG Publications, Star City WV VL - 31 IS - 5 SN - 1087-3244, 1087-3244 KW - blood pressure, nutrition, physical activity, fitness, lifestyle KW - Fitness KW - Physical activity KW - Nutrition KW - Blood pressure KW - Lifestyle KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57223526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Health+Behavior&rft.atitle=Effects+of+Individual+Components+of+Multiple+Behavior+Changes%3A+The+PREMIER+Trial&rft.au=Obarzanek%2C+Eva%3BVollmer%2C+William+M%3BLin%2C+Pao-Hwa%3BCooper%2C+Lawton+S%3BYoung%2C+Deborah+R%3BArd%2C+Jamy+D%3BStevens%2C+Victor+J%3BSimons-Morton%2C+Denise+G%3BSvetkey%2C+Laura+P%3BHarsha%2C+David+W%3BElmer%2C+Patricia+J%3BAppel%2C+Lawrence+J&rft.aulast=Obarzanek&rft.aufirst=Eva&rft.date=2007-09-01&rft.volume=31&rft.issue=5&rft.spage=545&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Health+Behavior&rft.issn=10873244&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-03-04 N1 - Last updated - 2016-09-27 N1 - CODEN - AJHBF6 N1 - SubjectsTermNotLitGenreText - Blood pressure; Physical activity; Fitness; Lifestyle; Nutrition ER - TY - JOUR T1 - Seat Belt Use Among American Indians/Alaska Natives and Non-Hispanic Whites AN - 57089888; 200802022 AB - Background: Accidents (including motor vehicle injuries) are a leading cause of death among American Indians/Alaskan Natives (AI/AN). The purpose of this study was to examine geographic variation and the existence of a seat belt law on seat belt use among AI/AN and non-Hispanic whites (NHW). Methods: Self-reported seat belt behavior data from the 1997 and 2002 Behavioral Risk Factor Surveillance System were analyzed in 2006-2007 and were restricted to AI/AN (n=4310 for 2002, and n=1758 for 1997) and NHW (n=193,6l7 for 2002, and n=108,551 for 1997) aged 18 years and older. Results: Seat belt non-use varied significantly across geographic regions for both AI/AN and NHW. For example, AI/AN living in the Northern Plains (odds ratio [OR]=12.4, 95% confidence interval [CI]=6.5-23.7) and Alaska (OR=10.3, 95%CI=5.3-19.9) had significantly higher seat belt non-use compared to AI/AN living in the West. In addition, compared to those residing in urban areas, those living in rural areas were 60% more likely in NHW and 2.6 times more likely in AI/AN not to wear a seat belt. Both AI/AN and NHW living in states without primary seat belt laws were approximately twice as likely to report seat belt non-use in 2002 as those living in states with primary laws. In states with primary laws enacted between 1997 and 2002, AI/AN experienced greater decline in seat belt non-use than NHW. Conclusions: Seat belt use among AI/AN and NHW varied significantly by region and urban-rural residency in 2002. Primary seat belt laws appear to help reduce regional and racial disparities in seat belt non-use. [Copyright 2007 American Journal of Preventive Medicine; published by Elsevier Inc.] JF - American Journal of Preventive Medicine AU - Garcia, Andrea N AU - Patel, Kushang V AU - Guralnik, Jack M AD - Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Gateway Building, Suite 3C-309, 7201 Wisconsin Ave., MSC 9205, Bethesda MD 20892-9205 Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 200 EP - 206 PB - Elsevier Science, New York NY VL - 33 IS - 3 SN - 0749-3797, 0749-3797 KW - American Indian people KW - Users KW - Seatbelts KW - Motor vehicles KW - Law KW - Alaska Native people KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57089888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Seat+Belt+Use+Among+American+Indians%2FAlaska+Natives+and+Non-Hispanic+Whites&rft.au=Garcia%2C+Andrea+N%3BPatel%2C+Kushang+V%3BGuralnik%2C+Jack+M&rft.aulast=Garcia&rft.aufirst=Andrea&rft.date=2007-09-01&rft.volume=33&rft.issue=3&rft.spage=200&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2007.04.032 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-02-04 N1 - Last updated - 2016-09-27 N1 - CODEN - AJPMEA N1 - SubjectsTermNotLitGenreText - Alaska Native people; American Indian people; Motor vehicles; Law; Users; Seatbelts DO - http://dx.doi.org/10.1016/j.amepre.2007.04.032 ER - TY - CPAPER T1 - Cardioprotective Effects of Zileuton 5-Lo Inhibitor, is Mediated by COX-2 via PKC Delta Activation. T2 - 2007 Meeting of the European Life Scientist Organization (ELSO 2007) AN - 39587648; 4722781 JF - 2007 Meeting of the European Life Scientist Organization (ELSO 2007) AU - Kwak, Hyun-Jeong AU - Park, Kyoung-Mi AU - Lee, Seahyoung AU - Lee, Hyung-Hee AU - Yang, Hee-Jun AU - Park, Hyun-Young Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 KW - Deltas KW - Cyclooxygenase-2 KW - Protein kinase C KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39587648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Meeting+of+the+European+Life+Scientist+Organization+%28ELSO+2007%29&rft.atitle=Cardioprotective+Effects+of+Zileuton+5-Lo+Inhibitor%2C+is+Mediated+by+COX-2+via+PKC+Delta+Activation.&rft.au=Kwak%2C+Hyun-Jeong%3BPark%2C+Kyoung-Mi%3BLee%2C+Seahyoung%3BLee%2C+Hyung-Hee%3BYang%2C+Hee-Jun%3BPark%2C+Hyun-Young&rft.aulast=Kwak&rft.aufirst=Hyun-Jeong&rft.date=2007-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Meeting+of+the+European+Life+Scientist+Organization+%28ELSO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.elso.org/index.php?id=elso2007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Religion and substance abuse treatment: individual and program effects AN - 36914553; 3562190 AB - The relationship between personal religiousness and substance abuse treatment outcomes has emerged as an important issue in the public health arena. Using the 'moral community' perspective, a conceptual framework developed by Stark, Kent, and Doyle (1982) to analyze the contextual effects of religion, we explore the degree to which religion influences two drug treatment outcome measures-critical retention and commitment to treatment. The data are derived from the Drug Abuse Treatment Outcome Studies (DATOS), a national study of 10,010 clients enrolled in 70 drug treatment programs. Three research questions were addressed: (1) What is the relationship between an individual's level of religiosity and retention in treatment and commitment to treatment? (2) How does the ecological context of treatment programs shape the individual-level relationships? (3) To what extent are program practices and characteristics directly linked to outcome level? The findings are supportive of the literature that shows a weak to moderate relationship between religiosity and treatment outcomes. However, the findings did not show strong support for the 'moral community' hypothesis. Although there was a wide variation in the size of the individual-level religiosity-treatment correlations, the variation could not be conclusively attributed to the overall religious emphasis of the programs. The findings suggest that further research is needed in order to understand fully the role of religion in substance abuse treatment. Reprinted by permission of Society for the Scientific Study of Religion JF - Journal for the scientific study of religion AU - Shields, Joseph J AU - Broome, Kirk M AU - Delany, Peter J AU - Fletcher, Bennett W AU - Flynn, Patrick M AD - Catholic University of America ; Texas Christian University ; National Institutes of Health Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 355 EP - 372 VL - 46 IS - 3 SN - 0021-8294, 0021-8294 KW - Sociology KW - Dependency rehabilitation KW - Religiosity KW - Drug addiction KW - Sociological methodology KW - Science KW - Substance abuse KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36914553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+for+the+scientific+study+of+religion&rft.atitle=Religion+and+substance+abuse+treatment%3A+individual+and+program+effects&rft.au=Shields%2C+Joseph+J%3BBroome%2C+Kirk+M%3BDelany%2C+Peter+J%3BFletcher%2C+Bennett+W%3BFlynn%2C+Patrick+M&rft.aulast=Shields&rft.aufirst=Joseph&rft.date=2007-09-01&rft.volume=46&rft.issue=3&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Journal+for+the+scientific+study+of+religion&rft.issn=00218294&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 11325; 12356 12357; 10766 12024 10762; 10449 5772; 3744 561 6220; 3432 12356 12357; 12001 7994 ER - TY - JOUR T1 - Embryonic stem cell patents and human dignity AN - 36894554; 3545991 AB - This article examines the assertion that human embryonic stem cells patents are immoral because they violate human dignity. After analyzing the concept of human dignity and its role in bioethics debates, this article argues that patents on human embryos or totipotent embryonic stem cells violate human dignity, but that patents on pluripotent or multipotent stem cells do not. Since patents on pluripotent or multipotent stem cells may still threaten human dignity by encouraging people to treat embryos as property, patent agencies should carefully monitor and control these patents to ensure that patents are not inadvertently awarded on embryos or totipotent stem cells. Reprinted by permission of Springer JF - Health care analysis AU - Resnik, D B AD - National Institutes of Health, USA Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 211 EP - 222 VL - 15 IS - 3 SN - 1065-3058, 1065-3058 KW - Political Science KW - Morality KW - Patents KW - Foetus KW - Bioethics KW - Health policy KW - Policy studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36894554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+care+analysis&rft.atitle=Embryonic+stem+cell+patents+and+human+dignity&rft.au=Resnik%2C+D+B&rft.aulast=Resnik&rft.aufirst=D&rft.date=2007-09-01&rft.volume=15&rft.issue=3&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Health+care+analysis&rft.issn=10653058&rft_id=info:doi/10.1007%2Fs10728-007-0045-9 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5080 11574; 8281 6085; 9266; 1603 4408 8282 8281 6085; 5788 11888 10472; 9628 DO - http://dx.doi.org/10.1007/s10728-007-0045-9 ER - TY - JOUR T1 - Mark tests for mirror self-recognition in Capuchin monkeys (Cebus apella) trained to touch marks AN - 36864854; 3534430 AB - In Experiment 1, three capuchin monkeys (Cebus apella) were exposed to a mirror in their home cage for 3 days and then given food treats for touching orange marks located on the surface of an experimental chamber. Following training, a mirror was added to the chamber to see if the monkeys would use it to guide non-reinforced contacts with an orange mark on their foreheads that was only visible as a mirror reflection (mark test). Two monkeys touched the head-mark more often with the mirror present than absent, but no mark touches were emitted while looking at the mirror. In Experiment 2, the monkeys were rewarded for touching orange marks on their bodies that were directly visible, followed by another head-mark test. Again, two monkeys touched the mark more often with the mirror present than absent, but these contacts were not emitted while looking at the mirror. Since facing the mirror while mark touching was not required for reinforcement during training, Experiment 3 further tested the possibility that increased mark touching in the presence of the mirror during Experiments 1 and 2 was the result of a memorial process. For this, a final, novel mark test was conducted using an orange mark on the neck that was only visible as a reflection (Experiment 3). No monkeys passed this test. These are the first mark tests given to capuchin monkeys. The results are consistent with the finding that no monkey species is capable of spontaneous mirror self-recognition. The implications of sequential training and mark testing for comparative evaluations of mirror self-recognition capacity are discussed. Copyright John Wiley & Sons. Reproduced with permission. An electronic version of this article is available online at http://www.interscience.wiley.com JF - American journal of primatology AU - Roma, Peter G AU - Silberberg, Alan AU - Huntsberry, Mary E AU - Christensen, Chesley J AU - Ruggiero, Angela M AU - Suomi, Stephen J AD - American University Washington DC ; National Institute of Child Health and Human Development, Poolesville Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 989 EP - 1000 VL - 69 IS - 9 SN - 0275-2565, 0275-2565 KW - Anthropology KW - Capuchin monkeys KW - Experiments KW - Intelligence KW - Physical anthropology KW - Primatology KW - Training KW - Self KW - Primates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36864854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+primatology&rft.atitle=Mark+tests+for+mirror+self-recognition+in+Capuchin+monkeys+%28Cebus+apella%29+trained+to+touch+marks&rft.au=Roma%2C+Peter+G%3BSilberberg%2C+Alan%3BHuntsberry%2C+Mary+E%3BChristensen%2C+Chesley+J%3BRuggiero%2C+Angela+M%3BSuomi%2C+Stephen+J&rft.aulast=Roma&rft.aufirst=Peter&rft.date=2007-09-01&rft.volume=69&rft.issue=9&rft.spage=989&rft.isbn=&rft.btitle=&rft.title=American+journal+of+primatology&rft.issn=02752565&rft_id=info:doi/10.1002%2Fajp.20404 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 9507 1077; 11442 6191; 6608 6085; 12894; 4636 6845 6564 12622; 10148; 10149 DO - http://dx.doi.org/10.1002/ajp.20404 ER - TY - JOUR T1 - Improving Healthcare Accessibility through Point-of-Care Technologies AN - 214004368; 17660275 AB - The NIH is committed to improving healthcare quality in the US and has set up initiatives to address problems such as the fragmented nature of healthcare provision. A hypothesis has been developed that testing closer to the point at which care is delivered may reduce fragmentation of care and improve outcomes. The National Institute of Biomedical Imaging and Bioengineering (NIBIB), the NIH's National Heart, Lung, and Blood Institute, and the National Science Foundation sponsored a workshop, "Improving Health Care Accessibility through Point-of-Care Technologies," in April 2006. The workshop assessed the clinical needs and opportunities for point-of-care (POC) technologies in primary care, the home, and emergency medical services and reviewed minimally invasive and noninvasive testing, including imaging, and conventional testing based on sensor and lab-on-a-chip technologies. Emerging needs of informatics and telehealth and healthcare systems engineering were considered in the POC testing context. Additionally, implications of evidence-based decision-making were reviewed, particularly as it related to the challenges in producing reliable evidence, undertaking regulation, implementing evidence responsibly, and integrating evidence into health policy. Many testing procedures were considered to be valuable in the clinical settings discussed. Technological solutions were proposed to meet these needs, as well as the practical requirements around clinical process change and regulation. From these considerations, a series of recommendations was formulated for development of POC technologies based on input from the symposium attendees. NIBIB has developed a funding initiative to establish a Point-of-Care Technologies Research Network that will work to bridge the technology/clinical gap and provide the partnerships necessary for the application of technologies to pressing clinical needs in POC testing. JF - Clinical Chemistry AU - Price, Christopher P AU - Kricka, Larry J Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 1665 EP - 75 CY - Washington PB - American Association for Clinical Chemistry VL - 53 IS - 9 SN - 00099147 KW - Medical Sciences KW - Health care KW - Emergency medical care KW - Hospitals KW - Quality of care KW - Personal health KW - Family physicians KW - Technological change KW - Risk assessment KW - Research methodology KW - Neurological disorders KW - Multiple sclerosis KW - Heart failure KW - Health services KW - Families & family life KW - Clinical trials KW - Blood pressure KW - Primary care KW - United States KW - Biomedical Technology -- trends KW - Evidence-Based Medicine KW - Telemedicine -- trends KW - Humans KW - Computational Biology -- trends KW - Clinical Laboratory Techniques KW - National Institutes of Health (U.S.) KW - Point-of-Care Systems -- organization & administration KW - Diagnostic Techniques & Procedures KW - Health Services Accessibility UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/214004368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Clinical+Chemistry&rft.atitle=Improving+Healthcare+Accessibility+through+Point-of-Care+Technologies&rft.au=Price%2C+Christopher+P%3BKricka%2C+Larry+J&rft.aulast=Price&rft.aufirst=Christopher&rft.date=2007-09-01&rft.volume=53&rft.issue=9&rft.spage=1665&rft.isbn=&rft.btitle=&rft.title=Clinical+Chemistry&rft.issn=00099147&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Association for Clinical Chemistry Sep 2007 N1 - Document feature - Tables; Diagrams; References N1 - Last updated - 2016-12-03 ER - TY - JOUR T1 - Medication Adherence and Sexual Risk Behavior among HIV-Infected Adults: Implications for Transmission of Resistant Virus AN - 211250998; 17243012 AB - As more people are living long-term with HIV there are growing concerns about specific behaviors that can affect both personal and the public health. This study examined the relationship between antiretroviral therapy (ART) adherence and sexual risk behavior and their association with psychosocial and health factors among a diverse sample of 2,849 HIV-infected adults. Only 8.5% of the sample reported both non-adherence and sexual risk. Individuals were 46% more likely to report one of these risk outcomes when the other one was present and the presence of both outcomes was associated with an increased likelihood of having a detectable viral load. A simultaneous polytomous regression analysis revealed complex relationships among a range of psychosocial variables and the two primary behavioral risk outcomes. There is a need for targeted interventions and integration of mental health and substance use services into primary HIV care settings. [PUBLICATION ABSTRACT] JF - AIDS and Behavior AU - Remien, Robert H AU - Exner, Theresa M AU - Morin, Stephen F AU - Ehrhardt, Anke A AU - Johnson, Mallory O AU - Correale, Jackie AU - Marhefka, Stephanie AU - Kirshenbaum, Sheri B AU - Weinhardt, Lance S AU - Rotheram-Borus, Mary Jane AU - Catz, Sheryl L AU - Gore-Felton, Cheryl AU - Chesney, Margaret A Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 663 EP - 75 CY - New York PB - Springer Science & Business Media VL - 11 IS - 5 SN - 10907165 KW - Psychology KW - Anti-Retroviral Agents KW - Depressive Disorder -- epidemiology KW - Questionnaires KW - Alcoholism -- epidemiology KW - Humans KW - Anxiety Disorders -- diagnosis KW - Adult KW - Depressive Disorder -- diagnosis KW - Social Support KW - Anxiety Disorders -- epidemiology KW - Male KW - Female KW - Sexual Behavior KW - Patient Compliance -- statistics & numerical data KW - Drug Resistance, Viral KW - Risk-Taking KW - HIV Infections -- transmission KW - HIV Infections -- drug therapy KW - HIV Infections -- epidemiology KW - Anti-Retroviral Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/211250998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acriminaljusticeperiodicals&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=Medication+Adherence+and+Sexual+Risk+Behavior+among+HIV-Infected+Adults%3A+Implications+for+Transmission+of+Resistant+Virus&rft.au=Remien%2C+Robert+H%3BExner%2C+Theresa+M%3BMorin%2C+Stephen+F%3BEhrhardt%2C+Anke+A%3BJohnson%2C+Mallory+O%3BCorreale%2C+Jackie%3BMarhefka%2C+Stephanie%3BKirshenbaum%2C+Sheri+B%3BWeinhardt%2C+Lance+S%3BRotheram-Borus%2C+Mary+Jane%3BCatz%2C+Sheryl+L%3BGore-Felton%2C+Cheryl%3BChesney%2C+Margaret+A&rft.aulast=Remien&rft.aufirst=Robert&rft.date=2007-09-01&rft.volume=11&rft.issue=5&rft.spage=663&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-006-9201-8 LA - English DB - ProQuest Central N1 - Copyright - Springer Science+Business Media, LLC 2007 N1 - Last updated - 2014-08-30 N1 - CODEN - AIBEFC DO - http://dx.doi.org/10.1007/s10461-006-9201-8 ER - TY - JOUR T1 - Lung Cancer and History of Pulmonary Tuberculosis among the U.S. Elderly AN - 21120831; 9271141 JF - Annals of Epidemiology AU - Yu, Y AU - Pfeiffer, R AU - Engels, E A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 741 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 17 IS - 9 SN - 1047-2797, 1047-2797 KW - Microbiology Abstracts B: Bacteriology KW - Mycobacterium KW - Geriatrics KW - Tuberculosis KW - Lung cancer KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21120831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Lung+Cancer+and+History+of+Pulmonary+Tuberculosis+among+the+U.S.+Elderly&rft.au=Yu%2C+Y%3BPfeiffer%2C+R%3BEngels%2C+E+A&rft.aulast=Yu&rft.aufirst=Y&rft.date=2007-09-01&rft.volume=17&rft.issue=9&rft.spage=741&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Geriatrics; Tuberculosis; Lung cancer; Mycobacterium ER - TY - JOUR T1 - Helicobacter pylori VacA Enhances Prostaglandin E sub(2) Production through Induction of Cyclooxygenase 2 Expression via a p38 Mitogen-Activated Protein Kinase/Activating Transcription Factor 2 Cascade in AZ-521 Cells AN - 21009214; 7557099 AB - Treatment of AZ-521 cells with Helicobacter pylori VacA increased cyclooxygenase 2 (COX-2) mRNA in a time- and dose-dependent manner. A p38 mitogen-activated protein kinase (MAPK) inhibitor, SB203580, blocked elevation of COX-2 mRNA levels, whereas PD98059, which blocks the Erk1/2 cascade, partially suppressed the increase. Consistent with involvement of p38 MAPK, VacA-induced accumulation of COX-2 mRNA was reduced in AZ-521 cells overexpressing a dominant-negative p38 MAPK (DN-p38). Phosphatidylinositol-specific phospholipase C, which inhibits VacA-induced p38 MAPK activation, blocked VacA-induced COX-2 expression. In parallel with COX-2 expression, VacA increased prostaglandin E sub(2) (PGE sub(2)) production, which was inhibited by SB203580 and NS-398, a COX-2 inhibitor. VacA-induced PGE sub(2) production was markedly attenuated in AZ-521 cells stably expressing DN-p38. VacA increased transcription of a COX-2 promoter reporter gene and activated a COX-2 promoter containing mutated NF- Kappa B or NF-interleukin-6 sites but not a mutated cis-acting replication element (CRE) site, suggesting direct involvement of the activating transcription factor 2 (ATF-2)/CREB-binding region in VacA-induced COX-2 promoter activation. The reduction of ATF-2 expression in AZ-521 cells transformed with ATF-2-small interfering RNA duplexes resulted in suppression of COX-2 expression. Thus, VacA enhances PGE sub(2) production by AZ-521 cells through induction of COX-2 expression via the p38 MAPK/ATF-2 cascade, leading to activation of the CRE site in the COX-2 promoter. JF - Infection and Immunity AU - Hisatsune, Junzo AU - Yamasaki, Eiki AU - Nakayama, Masaaki AU - Shirasaka, Daisuke AU - Kurazono, Hisao AU - Katagata, Yohtaro AU - Inoue, Hiroyasu AU - Han, Jiahuai AU - Sap, Jan AU - Yahiro, Kinnosuke AU - Moss, Joel AU - Hirayama, Toshiya AD - Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 8528523, Japan. Division of Digestive Disease, Kobe University Graduate School of Medicine, Kobe 6500017, Japan. Laboratory of Veterinary Public Health, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka 5998531, Japan. Department of Biochemistry and Biotechnology, Faculty of Agriculture and Life Science, Hirosaki University, Hirosaki 0368561, Japan. Department of Food and Nutrition, Nara Women's University, Nara 6308506, Japan. Department of Immunology, The Scripps Research Institute, La Jolla, California 92037. Department of Molecular Pathology, University of Copenhagen, Copenhagen DK-2100, Denmark. Pulmonary-Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892-1590 Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 4472 EP - 4481 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 9 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Cyclooxygenase-2 KW - Helicobacter pylori KW - Promoters KW - Extracellular signal-regulated kinase KW - MAP kinase KW - Replication KW - Reporter gene KW - Activating transcription factor 2 KW - Phospholipase C KW - Prostaglandin E2 KW - NF- Kappa B protein KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21009214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Helicobacter+pylori+VacA+Enhances+Prostaglandin+E+sub%282%29+Production+through+Induction+of+Cyclooxygenase+2+Expression+via+a+p38+Mitogen-Activated+Protein+Kinase%2FActivating+Transcription+Factor+2+Cascade+in+AZ-521+Cells&rft.au=Hisatsune%2C+Junzo%3BYamasaki%2C+Eiki%3BNakayama%2C+Masaaki%3BShirasaka%2C+Daisuke%3BKurazono%2C+Hisao%3BKatagata%2C+Yohtaro%3BInoue%2C+Hiroyasu%3BHan%2C+Jiahuai%3BSap%2C+Jan%3BYahiro%2C+Kinnosuke%3BMoss%2C+Joel%3BHirayama%2C+Toshiya&rft.aulast=Hisatsune&rft.aufirst=Junzo&rft.date=2007-09-01&rft.volume=75&rft.issue=9&rft.spage=4472&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cyclooxygenase-2; Extracellular signal-regulated kinase; Promoters; MAP kinase; Reporter gene; Replication; Phospholipase C; Activating transcription factor 2; Prostaglandin E2; NF- Kappa B protein; Helicobacter pylori ER - TY - JOUR T1 - Staphylococcus aureus Biofilm Metabolism and the Influence of Arginine on Polysaccharide Intercellular Adhesin Synthesis, Biofilm Formation, and Pathogenesis AN - 21003563; 7557070 AB - Staphylococcus aureus and Staphylococcus epidermidis are the leading causes of nosocomial infections in the United States and often are associated with biofilms attached to indwelling medical devices. Despite the importance of biofilms, there is very little consensus about the metabolic requirements of S. aureus during biofilm growth. To assess the metabolic requirements of S. aureus growing in a biofilm, we grew USA200 and USA300 clonal types in biofilm flow cells and measured the extraction and accumulation of metabolites. In spite of the genetic differences, both clonal types extracted glucose and accumulated lactate, acetate, formate, and acetoin, suggesting that glucose was catabolized to pyruvate that was then catabolized via the lactate dehydrogenase, pyruvate formate-lyase, and butanediol pathways. Additionally, both clonal types selectively extracted the same six amino acids (serine, proline, arginine, glutamine, glycine, and threonine) from the culture medium. These data and recent speculation about the importance of arginine in biofilm growth and the function of arginine deiminase in USA300 clones led us to genetically inactivate the sole copy of the arginine deiminase operon by deleting the arginine/ornithine antiporter gene (arcD) in the USA200 clonal type and to assess the effect on biofilm development and pathogenesis. Although inactivation of arcD did completely inhibit arginine transport and did reduce polysaccharide intercellular adhesin accumulation, arcD mutants formed biofilms and achieved cell densities in catheter infection studies that were equivalent to those for isogenic wild-type strains. JF - Infection and Immunity AU - Zhu, Yefei AU - Weiss, Elizabeth C AU - Otto, Michael AU - Fey, Paul D AU - Smeltzer, Mark S AU - Somerville, Greg A AD - Department of Veterinary and Biomedical Sciences, University of Nebraska, Lincoln, Nebraska 68583. Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205. Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840. Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 4219 EP - 4226 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 9 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Adhesins KW - Glutamine KW - Cell density KW - Glucose KW - Cell culture KW - Metabolites KW - Polysaccharides KW - Pyruvic acid KW - ornithine KW - Biofilms KW - Staphylococcus aureus KW - Serine KW - Proline KW - Data processing KW - Amino acids KW - Acetoin KW - Glycine KW - Arginine KW - Acetic acid KW - L-Lactate dehydrogenase KW - Nosocomial infection KW - Catheters KW - Lactic acid KW - Arginine deiminase KW - Operons KW - Staphylococcus epidermidis KW - Threonine KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21003563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Staphylococcus+aureus+Biofilm+Metabolism+and+the+Influence+of+Arginine+on+Polysaccharide+Intercellular+Adhesin+Synthesis%2C+Biofilm+Formation%2C+and+Pathogenesis&rft.au=Zhu%2C+Yefei%3BWeiss%2C+Elizabeth+C%3BOtto%2C+Michael%3BFey%2C+Paul+D%3BSmeltzer%2C+Mark+S%3BSomerville%2C+Greg+A&rft.aulast=Zhu&rft.aufirst=Yefei&rft.date=2007-09-01&rft.volume=75&rft.issue=9&rft.spage=4219&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Adhesins; Glutamine; Cell density; Glucose; Metabolites; Cell culture; Polysaccharides; Pyruvic acid; ornithine; Biofilms; Serine; Proline; Amino acids; Data processing; Acetoin; Arginine; Glycine; Acetic acid; L-Lactate dehydrogenase; Nosocomial infection; Lactic acid; Catheters; Arginine deiminase; Operons; Threonine; Staphylococcus aureus; Staphylococcus epidermidis ER - TY - JOUR T1 - Quantifying the blood oxygenation level dependent effect in cerebral blood volume-weighted functional MRI at 9.4T AN - 20855687; 8368573 AB - In cerebral blood volume (CBV)-weighted functional MRI (fMRI) employing superparamagnetic contrast agent, iron dose and blood oxygenation level dependent (BOLD) contamination are two important issues for experimental design and CBV quantification. Both BOLD and CBV-weighted fMRI are based upon the susceptibility effect, to which spin-echo and gradient-echo sequences have different sensitivities. In the present study, CBV-weighted fMRI was conducted using spin-echo and gradient-echo sequences at 9.4T by systematically changing the doses of contrast agent. Results suggest that BOLD contamination is a significant component in CBV-weighted fMRI at high field, particularly when relatively low dose of contrast agent is administered. A mathematical model was developed to quantify the extravascular (EV) BOLD effect. With a TE of 35 ms, the EV BOLD effect was estimated to account for 76 - 12% of the observed spin-echo fMRI signal at 9.4T. These data suggest that correcting BOLD effect may be necessary for accurately quantifying activation-induced CBV changes at high field. Magn Reson Med 58:616-621, 2007. JF - Magnetic Resonance in Medicine AU - Lu, Hanbing AU - Scholl, Clara A AU - Zuo, Yantao AU - Stein, Elliot A AU - Yang, Yihong AD - Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA, luha@intra.nida.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 616 EP - 621 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 58 IS - 3 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Mathematical models KW - Data processing KW - Contamination KW - Functional magnetic resonance imaging KW - Blood KW - Contrast media KW - N.M.R. KW - Iron KW - Cerebral blood flow KW - W 30910:Imaging KW - N3 11002:Computational & theoretical neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20855687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Quantifying+the+blood+oxygenation+level+dependent+effect+in+cerebral+blood+volume-weighted+functional+MRI+at+9.4T&rft.au=Lu%2C+Hanbing%3BScholl%2C+Clara+A%3BZuo%2C+Yantao%3BStein%2C+Elliot+A%3BYang%2C+Yihong&rft.aulast=Lu&rft.aufirst=Hanbing&rft.date=2007-09-01&rft.volume=58&rft.issue=3&rft.spage=616&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21354 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Functional magnetic resonance imaging; Contrast media; Contamination; Blood; Data processing; Iron; N.M.R.; Cerebral blood flow; Mathematical models DO - http://dx.doi.org/10.1002/mrm.21354 ER - TY - JOUR T1 - Increasing the Efficiency of Clinical Trials of Antimicrobials: The Scientific Basis of Substantial Evidence of Effectiveness of Drugs AN - 20855511; 8349762 AB - In the United States, drug sponsors must obtain approval from the US Food and Drug Administration before licensure and widespread clinical use of drugs. In this article, I discuss the definition and history of the regulatory requirement for "substantial evidence" of effectiveness from "adequate and well-controlled" clinical trials of drugs. These requirements apply to antimicrobials as they do to other therapeutic drug classes, and they may be even more important in their application to antimicrobials, given issues of antimicrobial resistance. I will discuss the evidence requirements, using examples from clinical trials in diseases such as acute otitis media, acute bacterial sinusitis, and acute exacerbations of chronic bronchitis. Examination of the principles of substantial evidence also points to opportunities to improve the efficiency of confirmatory clinical trials of antimicrobials to obtain more clinically relevant and useful information without increasing the uncertainty regarding the safety and efficacy of these drugs. JF - Clinical Infectious Diseases AU - Powers, J H AD - 6700B Rockledge Dr., Rm. 1123, Bethesda, MD 20892, USA, powersjohn@mail.nih.gov Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - S153 EP - S162 VL - 45 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts B: Bacteriology KW - Otitis media KW - Drug resistance KW - Bronchitis KW - Sinusitis KW - Clinical trials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20855511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Increasing+the+Efficiency+of+Clinical+Trials+of+Antimicrobials%3A+The+Scientific+Basis+of+Substantial+Evidence+of+Effectiveness+of+Drugs&rft.au=Powers%2C+J+H&rft.aulast=Powers&rft.aufirst=J&rft.date=2007-09-01&rft.volume=45&rft.issue=&rft.spage=S153&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/10.1086%2F519253 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Drug resistance; Otitis media; Bronchitis; Sinusitis; Clinical trials DO - http://dx.doi.org/10.1086/519253 ER - TY - JOUR T1 - The anti-inflammatory activities of Staphylococcus aureus AN - 20848067; 8242534 AB - Staphylococcus aureus is a versatile and harmful pathogen in both hospital- and community-associated infections that range from superficial to systemic infections. S. aureus engages a multitude of mechanisms to subvert the innate immune response of the host, including inhibition of complement activation and neutralization of anti-microbial peptides. In addition, inflammatory cell and phagocyte recruitment is an integral part of the innate defense to staphylococcal infection and comprises a well-coordinated multi-step cascade of adhesive events. Recent and rapidly growing experimental evidence indicates the existence of a machinery of anti-adhesive and anti-chemotactic moieties of S. aureus that allow the bacterium to interfere with specific adhesive steps of the homing mechanism of leukocytes. Understanding the functions of these S. aureus-derived anti-inflammatory agents could also provide the platform for designing new therapies in several inflammatory and autoimmune diseases. JF - Trends in Immunology AU - Chavakis, T AU - Preissner, K T AU - Herrmann, M Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 408 EP - 418 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 28 IS - 9 SN - 1471-4906, 1471-4906 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Autoimmune diseases KW - Leukocytes KW - Disseminated infection KW - Pathogens KW - Cell adhesion KW - Inflammation KW - Leukocyte migration KW - Inflammatory diseases KW - Phagocytes KW - Reviews KW - Complement activation KW - Immune response KW - Staphylococcus aureus KW - Adhesives KW - Antimicrobial peptides KW - Antiinflammatory agents KW - F 06930:Autoimmunity KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20848067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Immunology&rft.atitle=The+anti-inflammatory+activities+of+Staphylococcus+aureus&rft.au=Chavakis%2C+T%3BPreissner%2C+K+T%3BHerrmann%2C+M&rft.aulast=Chavakis&rft.aufirst=T&rft.date=2007-09-01&rft.volume=28&rft.issue=9&rft.spage=408&rft.isbn=&rft.btitle=&rft.title=Trends+in+Immunology&rft.issn=14714906&rft_id=info:doi/10.1016%2Fj.it.2007.07.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Disseminated infection; Leukocytes; Autoimmune diseases; Pathogens; Inflammation; Cell adhesion; Leukocyte migration; Inflammatory diseases; Phagocytes; Reviews; Complement activation; Immune response; Adhesives; Antiinflammatory agents; Antimicrobial peptides; Staphylococcus aureus DO - http://dx.doi.org/10.1016/j.it.2007.07.002 ER - TY - JOUR T1 - Metabolomic and Genetic Analysis of Biomarkers for Peroxisome Proliferator-Activated Receptor alpha Expression and Activation AN - 20800008; 7559538 AB - Peroxisome proliferator-activated receptor alpha (PPAR alpha ) is a nuclear receptor with manifold effects on intermediary metabolism. To define a set of urinary biomarkers that could be used to determine the efficacy of PPAR alpha agonists, a metabolomic investigation was undertaken in wild-type and Ppar alpha -null mice fed for 2 wk either a regular diet or a diet containing the PPAR alpha ligand Wy-14,643 ([4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio] acetic acid), and their urine was analyzed by ultra-performance liquid chromatography coupled with time-of-flight mass spectrometry. Principal components analysis of 6393 accurate mass positive ions revealed clustering as a single phenotype of the treated and untreated Ppar alpha (-/-) mice plus two additional discrete phenotypes for the treated and untreated Ppar alpha (+/+) mice. Biomarkers of PPAR alpha activation were identified from their accurate masses and confirmed by tandem mass spectrometry of authentic compounds. Biomarkers were quantitated from raw chromatographic data using appropriate calibration curves. PPAR alpha urinary biomarkers highly statistically significantly elevated by Wy-14,643 treatment included 11{szligbeta}-hydroxy-3,20-dioxopregn-4-en-21-oic acid (>3700-fold), 11{szligbeta},20-dihydroxy-3-oxopregn-4-en-21-oic acid (50-fold), nicotinamide (>2-fold), nicotinamide 1-oxide (5-fold), 1-methylnicotinamide (1.5-fold), hippuric acid (2-fold), and 2,8-dihydroxyquinoline-{szligbeta}-D-glucuronide (3-fold). PPAR alpha urinary biomarkers highly statistically significantly attenuated by Wy-14,643 treatment included xanthurenic acid (1.3-fold), hexanoylglycine (20-fold), phenylpropionylglycine (4-fold), and cinnamoylglycine (9-fold). These biomarkers arise from PPAR alpha effects on tryptophan, corticosterone, and fatty acid metabolism and on glucuronidation. This study underscores the power of mass spectrometry-based metabolomics combined with genetically modified mice in the definition of monogenic metabolic phenotypes. JF - Molecular Endocrinology AU - Zhen, Yueying AU - Krausz, Kristopher W AU - Chen, Chi AU - Idle, Jeffrey R AU - Gonzalez, Frank J AD - Laboratory of Metabolism (Y.Z., K.W.K., C.C., F.J.G.), National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 2136 EP - 2151 PB - Endocrine Society, 8400 Connecticut Ave Suite 900 Chevy Chase MD 20815-5817 USA, [mailto:societyservices@endo-society.org], [URL:http://www.endo-society.org/] VL - 21 IS - 9 SN - 0888-8809, 0888-8809 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Diets KW - Ions KW - Tryptophan KW - Data processing KW - Peroxisome proliferator-activated receptors KW - nicotinamide KW - Nuclear receptors KW - Genetic analysis KW - Acetic acid KW - biomarkers KW - Mass spectroscopy KW - xanthurenic acid KW - Corticosterone KW - Liquid chromatography KW - Urine KW - Principal components analysis KW - Fatty acids KW - Metabolism KW - metabolomics KW - G 07870:Mammals KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20800008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Endocrinology&rft.atitle=Metabolomic+and+Genetic+Analysis+of+Biomarkers+for+Peroxisome+Proliferator-Activated+Receptor+alpha+Expression+and+Activation&rft.au=Zhen%2C+Yueying%3BKrausz%2C+Kristopher+W%3BChen%2C+Chi%3BIdle%2C+Jeffrey+R%3BGonzalez%2C+Frank+J&rft.aulast=Zhen&rft.aufirst=Yueying&rft.date=2007-09-01&rft.volume=21&rft.issue=9&rft.spage=2136&rft.isbn=&rft.btitle=&rft.title=Molecular+Endocrinology&rft.issn=08888809&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Diets; Tryptophan; Ions; Data processing; Peroxisome proliferator-activated receptors; nicotinamide; Nuclear receptors; Genetic analysis; biomarkers; Acetic acid; Mass spectroscopy; xanthurenic acid; Corticosterone; Urine; Liquid chromatography; Principal components analysis; Fatty acids; metabolomics; Metabolism ER - TY - JOUR T1 - Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development AN - 20799072; 7565471 AB - Muscarinic acetylcholine receptors (mAChRs), M sub(1)-M sub(5), regulate the activity of numerous fundamental central and peripheral functions. The lack of small-molecule ligands that can block or activate specific mAChR subtypes with high selectivity has remained a major obstacle in defining the roles of the individual receptor subtypes and in the development of novel muscarinic drugs. Recently, phenotypic analysis of mutant mouse strains deficient in each of the five mAChR subtypes has led to a wealth of new information regarding the physiological roles of the individual receptor subtypes. Importantly, these studies have identified specific mAChR-regulated pathways as potentially novel targets for the treatment of various important disorders including Alzheimer's disease, schizophrenia, pain, obesity and diabetes. JF - Nature Reviews: Drug Discovery AU - Wess, Juergen AU - Eglen, Richard M AU - Gautam, Dinesh AD - Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0810, USA., jwess@helix.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 721 EP - 733 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 6 IS - 9 SN - 1474-1784, 1474-1784 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Diabetes mellitus KW - Schizophrenia KW - Obesity KW - Neurodegenerative diseases KW - Mental disorders KW - Reviews KW - Acetylcholine receptors (muscarinic) KW - Alzheimer's disease KW - Drug development KW - Pain KW - N3 11028:Neuropharmacology & toxicology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20799072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Drug+Discovery&rft.atitle=Muscarinic+acetylcholine+receptors%3A+mutant+mice+provide+new+insights+for+drug+development&rft.au=Wess%2C+Juergen%3BEglen%2C+Richard+M%3BGautam%2C+Dinesh&rft.aulast=Wess&rft.aufirst=Juergen&rft.date=2007-09-01&rft.volume=6&rft.issue=9&rft.spage=721&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Drug+Discovery&rft.issn=14741784&rft_id=info:doi/10.1038%2Fnrd2379 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Schizophrenia; Diabetes mellitus; Neurodegenerative diseases; Obesity; Mental disorders; Reviews; Alzheimer's disease; Acetylcholine receptors (muscarinic); Pain; Drug development DO - http://dx.doi.org/10.1038/nrd2379 ER - TY - JOUR T1 - The ongoing evolution of proteomics in malignancy AN - 20777000; 8242408 AB - The complementary fields of genomics and proteomics offer insights into the molecular mechanisms of diseases. While genomics seeks to define our genetic substrate, proteomics explores the structure and function of proteins, which are the end effectors of our genes. Proteomics has been revolutionized in the past decade by the application of techniques such as protein arrays, two-dimensional gel electrophoresis, and mass spectrometry. These techniques have tremendous potential for biomarker development, target validation, diagnosis, prognosis, and optimization of treatment in medical care, especially in the field of clinical oncology. We will discuss innovations in proteomic technologies and highlight their prospective applications to patient care. JF - Drug Discovery Today AU - Dhamoon, A S AU - Kohn, E C AU - Azad, N S AD - Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Dr. MSC 1500, Bethesda, MD 20892, United States, azadn@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 700 EP - 708 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 12 IS - 17-18 SN - 1359-6446, 1359-6446 KW - Biotechnology and Bioengineering Abstracts KW - Molecular modelling KW - Prognosis KW - Oncology KW - biomarkers KW - Mass spectroscopy KW - Gel electrophoresis KW - Malignancy KW - Structure-function relationships KW - Protein arrays KW - proteomics KW - genomics KW - Evolution KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20777000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Discovery+Today&rft.atitle=The+ongoing+evolution+of+proteomics+in+malignancy&rft.au=Dhamoon%2C+A+S%3BKohn%2C+E+C%3BAzad%2C+N+S&rft.aulast=Dhamoon&rft.aufirst=A&rft.date=2007-09-01&rft.volume=12&rft.issue=17-18&rft.spage=700&rft.isbn=&rft.btitle=&rft.title=Drug+Discovery+Today&rft.issn=13596446&rft_id=info:doi/10.1016%2Fj.drudis.2007.07.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Malignancy; Structure-function relationships; Protein arrays; Prognosis; Oncology; genomics; proteomics; biomarkers; Gel electrophoresis; Mass spectroscopy; Evolution DO - http://dx.doi.org/10.1016/j.drudis.2007.07.015 ER - TY - JOUR T1 - Identification of arsenic-binding proteins in human breast cancer cells AN - 20753130; 7602754 AB - As a cancer chemotherapeutic drug, arsenic acts on numerous intracellular signal transduction pathways in cancer cells. However, its mechanism of actions is still not fully understood. Previous studies suggest that arsenic reacts with closely spaced cysteine (Cys) residues of proteins with high Cys content and accessible sulfhydryl (SH) groups. In this study, human breast cancer cell line MCF-7 was examined as a cellular model to explore arsenic-binding proteins and the mechanism of binding. An arsenic-biotin conjugate was synthesized by coupling the pentafluorophenol ester of biotin with p-aminophenylarsenoxide. Arsenic-binding proteins were eluted with streptavidin resin from arsenic-biotin treated MCF-7 cells, separated by polyacrylamide gel electrophoresis, and identified by matrix assisted laser desorption ionization mass spectrometry (MALDI-MS). Arsenic-binding properties of two of these proteins, beta -tubulin and pyruvate kinase M2 (PKM2), were studied further in vitro and the biological consequences of this binding was evaluated. Binding assay with Western blotting confirmed binding of beta -tubulin and PKM2 by arsenic in a concentration-dependent manner. Arsenic binding inhibited tubulin polymerization, but surprisingly had no effect on PKM2 activity. Molecular modeling showed that binding of Cys12 alone or vicinal Cys residues (Cys12 and Cys213) of beta -tubulin by arsenic blocked the active site for access of GTP, which is necessary for tubulin polymerization. On the contrary, all Cys residues of PKM2 were far away from the active site of the enzyme. In summary, this study confirmed beta -tubulin and PKM2 as arsenic-binding proteins in MCF-7 cells. Functional consequence of such binding may depend on whether arsenic binding causes conformational changes or blocks active sites of target proteins. JF - Cancer Letters AU - Zhang, Xinyan AU - Yang, Fan AU - Shim, Joong-Youn AU - Kirk, Kenneth L AU - Anderson, D Eric AU - Chen, Xiaoxin AD - Cancer Research Program, Julius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, 700 George St., Durham, NC 27707, USA, fyang@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 95 EP - 106 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 255 IS - 1 SN - 0304-3835, 0304-3835 KW - Toxicology Abstracts KW - Arsenic KW - Cysteine KW - Breast cancer KW - Western blotting KW - Molecular modelling KW - Resins KW - Polymerization KW - Desorption KW - GTP KW - Enzymes KW - Esters KW - Mass spectroscopy KW - Gel electrophoresis KW - Pyruvate kinase KW - Tumor cell lines KW - pentafluorophenol KW - Lasers KW - Tubulin KW - Biotin KW - streptavidin KW - Signal transduction KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20753130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Letters&rft.atitle=Identification+of+arsenic-binding+proteins+in+human+breast+cancer+cells&rft.au=Zhang%2C+Xinyan%3BYang%2C+Fan%3BShim%2C+Joong-Youn%3BKirk%2C+Kenneth+L%3BAnderson%2C+D+Eric%3BChen%2C+Xiaoxin&rft.aulast=Zhang&rft.aufirst=Xinyan&rft.date=2007-09-01&rft.volume=255&rft.issue=1&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Cancer+Letters&rft.issn=03043835&rft_id=info:doi/10.1016%2Fj.canlet.2007.03.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Western blotting; Resins; Arsenic; Desorption; Polymerization; Enzymes; GTP; Esters; Gel electrophoresis; Mass spectroscopy; Pyruvate kinase; Tumor cell lines; pentafluorophenol; Cysteine; Breast cancer; Lasers; Tubulin; Biotin; Signal transduction; streptavidin DO - http://dx.doi.org/10.1016/j.canlet.2007.03.025 ER - TY - JOUR T1 - Alcohol, Smoking, and Body Size in Relation to Incident Hodgkin's and Non-Hodgkin's Lymphoma Risk AN - 20723319; 7554738 AB - Studies associate alcohol consumption, cigarette smoking, and body size with the risk of overall or subtype lymphoma. Current data come mostly from case-control studies or prospective studies with few cases. In the prospective National Institutes of Health-former American Association of Retired Persons (NIH-AARP) Diet and Health Study, the authors assessed the above lifestyle factors via baseline questionnaire among 285,079 men and 188,905 women aged 50-71 years and ascertained histologically confirmed Hodgkin's lymphoma (n = 58) and non-Hodgkin's lymphoma (n = 1,381) cases through linkage with cancer registries from 1995 to 2000. Compared with nondrinkers, alcohol consumers had a lower risk for non-Hodgkin's lymphoma overall (for >28 drinks/week: adjusted relative risk (RR) = 0.77, 95% confidence interval (CI): 0.59, 1.00; p sub(trend) among drinkers = 0.02) and for its main subtypes. Compared with never smokers, current smokers and recent quitters ( less than or equal to 4 years ago) had higher risk of Hodgkin's lymphoma (RR = 2.25, 95% CI: 1.04, 4.89; RR = 4.20, 95% CI: 1.94, 9.09, respectively), whereas current or former smokers had lower risk of follicular non-Hodgkin's lymphoma (RR = 0.67, 95% CI: 0.52, 0.86). Severe obesity (body mass index of greater than or equal to 35: RR = 1.29, 95% CI: 1.02, 1.64) and taller height (RR = 1.19, 95% CI: 1.03, 1.38) were associated moderately with non-Hodgkin's lymphoma. These findings add to the evidence that lifestyle factors and relevant anthropometric characteristics play a role in lymphoma etiology. JF - American Journal of Epidemiology AU - Lim, Unhee AU - Morton, Lindsay M AU - Subar, Amy F AU - Baris, Dalsu AU - Stolzenberg-Solomon, Rachael AU - Leitzmann, Michael AU - Kipnis, Victor AU - Mouw, Traci AU - Carroll, Leslie AU - Schatzkin, Arthur AU - Hartge, Patricia AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 697 EP - 708 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 166 IS - 6 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; Immunology Abstracts; Toxicology Abstracts KW - non-Hodgkin's lymphoma KW - Risk assessment KW - Hodgkin's disease KW - obesity KW - body size KW - Non-Hodgkin's lymphoma KW - body mass KW - Risk factors KW - Cigarette smoking KW - Body size KW - Consumers KW - Ethanol KW - Diets KW - Alcohol KW - Inventories KW - Obesity KW - Etiology KW - Beverages KW - Data processing KW - Cancer KW - Body mass index KW - lymphoma KW - X 24380:Social Poisons & Drug Abuse KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20723319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Alcohol%2C+Smoking%2C+and+Body+Size+in+Relation+to+Incident+Hodgkin%27s+and+Non-Hodgkin%27s+Lymphoma+Risk&rft.au=Lim%2C+Unhee%3BMorton%2C+Lindsay+M%3BSubar%2C+Amy+F%3BBaris%2C+Dalsu%3BStolzenberg-Solomon%2C+Rachael%3BLeitzmann%2C+Michael%3BKipnis%2C+Victor%3BMouw%2C+Traci%3BCarroll%2C+Leslie%3BSchatzkin%2C+Arthur%3BHartge%2C+Patricia&rft.aulast=Lim&rft.aufirst=Unhee&rft.date=2007-09-01&rft.volume=166&rft.issue=6&rft.spage=3452&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Diets; Risk assessment; Obesity; Inventories; Etiology; Data processing; Hodgkin's disease; Beverages; Cancer; Non-Hodgkin's lymphoma; Risk factors; Cigarette smoking; Body size; Consumers; Body mass index; Ethanol; non-Hodgkin's lymphoma; Alcohol; body mass; obesity; body size; lymphoma ER - TY - JOUR T1 - Effect of Concomitantly Administered Rifampin on the Pharmacokinetics and Safety of Atazanavir Administered Twice Daily AN - 20723216; 7553974 AB - The potent induction of hepatic cytochrome P450 3A isoforms by rifampin complicates therapy for coinfection with human immunodeficiency virus (HIV) and Mycobacterium tuberculosis. We performed an open-label, single-arm study to assess the safety and pharmacokinetic interactions of the HIV protease inhibitor atazanavir coadministered with rifampin. Ten healthy HIV-negative subjects completed pharmacokinetic sampling at steady state while receiving 300 mg atazanavir every 12 h without rifampin (period 1), 300 mg atazanavir every 12 h with 600 mg rifampin every 24 h (period 2), and 400 mg atazanavir every 12 h with 600 mg rifampin every 24 h (period 3). During period 1, the mean concentration of drug in serum at 12 h (C sub(12 h)) was 811 ng/ml (range, 363 to 2,484 ng/ml) for atazanavir, similar to historic seronegative data for once-daily treatment with 300 mg atazanavir boosted with 100 mg ritonavir. During periods 2 and 3, the mean C sub(12 h) values for atazanavir were 44 ng/ml (range, <25 to187 ng/ml) and 113 ng/ml (range, 39 to 260 ng/ml), respectively, well below historic seronegative data for once-daily treatment with 400 mg atazanavir without ritonavir. Although safe and generally well tolerated, 300 mg or 400 mg atazanavir administered every 12 h did not maintain adequate plasma exposure when coadministered with rifampin. JF - Antimicrobial Agents & Chemotherapy AU - Acosta, Edward P AU - Kendall, Michelle A AU - Gerber, John G AU - Alston-Smith, Beverly AU - Koletar, Susan L AU - Zolopa, Andrew R AU - Agarwala, Sangeeta AU - Child, Michael AU - Bertz, Richard AU - Hosey, Lara AU - Haas, David W AD - University of Alabama at Birmingham, Birmingham, Alabama. Statistical and Data Analysis Center, Harvard School of Public Health, Boston, Massachusetts. University of Colorado Health Sciences Center, Denver, Colorado. DAIDS, NIAID, NIH, Bethesda, Maryland. Ohio State University, Columbus, Ohio. Stanford University, Stanford, California. Bristol-Myers Squibb, Princeton, New Jersey. Social & Scientific Systems Inc., Silver Spring, Maryland. Vanderbilt University School of Medicine, Nashville, Tennessee Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 3104 EP - 3110 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 51 IS - 9 SN - 0066-4804, 0066-4804 KW - HIV KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Rifampin KW - Data processing KW - Human immunodeficiency virus KW - Ritonavir KW - Proteinase inhibitors KW - Liver KW - Cytochrome P450 KW - Sampling KW - Drugs KW - Pharmacokinetics KW - Mycobacterium tuberculosis KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20723216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Effect+of+Concomitantly+Administered+Rifampin+on+the+Pharmacokinetics+and+Safety+of+Atazanavir+Administered+Twice+Daily&rft.au=Acosta%2C+Edward+P%3BKendall%2C+Michelle+A%3BGerber%2C+John+G%3BAlston-Smith%2C+Beverly%3BKoletar%2C+Susan+L%3BZolopa%2C+Andrew+R%3BAgarwala%2C+Sangeeta%3BChild%2C+Michael%3BBertz%2C+Richard%3BHosey%2C+Lara%3BHaas%2C+David+W&rft.aulast=Acosta&rft.aufirst=Edward&rft.date=2007-09-01&rft.volume=51&rft.issue=9&rft.spage=3104&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Rifampin; Data processing; Ritonavir; Proteinase inhibitors; Liver; Sampling; Cytochrome P450; Drugs; Pharmacokinetics; Human immunodeficiency virus; Mycobacterium tuberculosis ER - TY - JOUR T1 - A quantum chemical study of the mechanism of action of Vitamin K carboxylase (VKC) AN - 20721295; 8284088 AB - A reaction path including transition states is generated for the Dowd mechanism [P. Dowd, R. Hershlne, S.W. Ham, S. Naganathan. Vitamin K and energy transduction: a base strength amplification mechanism. Science 269 (2005) 1684-1691] of action for Vitamin K carboxylase (VKC) using quantum chemical methods (B3LYP/6-311G**). VKC, an essential enzyme in mammalian systems, catalyzes the conversion of hydroquinone form of Vitamin K to the epoxide form in the presence of oxygen. An intermediate species of the oxidation of Vitamin K, an alkoxide, acts apparently to abstract the gamma hydrogen from specifically located glutamate residues. We are able to follow the Dowd proposed path to generate this alkoxide species. The geometries of the proposed model intermediates and transition states in the mechanism are energy optimized. We find that the most energetic step in the mechanism is the uni-deprotonation of the hydroquinone - once this occurs, there is only a small barrier of 3.5kcal/mol for the interaction of oxygen with the carbon to be attacked - and then the reaction proceeds downhill in free energy to form the critical alkoxide species. The results are consistent with the idea that the enzyme probably acts to facilitate the formation of the epoxide by reducing the energy required to deprotonate the hydroquinone form. JF - Journal of Molecular Graphics and Modelling AU - Davis, CH AU - Deerfield, D AU - Wymore, T AU - Stafford, D W AU - Pedersen, L G AD - NIEHS, Research Triangle Park, NC 27009, United States, Lee_Pedersen@unc.edu Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 409 EP - 414 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 26 IS - 2 SN - 1093-3263, 1093-3263 KW - Biotechnology and Bioengineering Abstracts KW - Epoxides KW - Hydroquinone KW - Energy transduction KW - Enzymes KW - Hydrogen KW - Free energy KW - Models KW - Oxygen KW - Carbon KW - Oxidation KW - Ham KW - Vitamin K KW - Glutamic acid KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20721295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Graphics+and+Modelling&rft.atitle=A+quantum+chemical+study+of+the+mechanism+of+action+of+Vitamin+K+carboxylase+%28VKC%29&rft.au=Davis%2C+CH%3BDeerfield%2C+D%3BWymore%2C+T%3BStafford%2C+D+W%3BPedersen%2C+L+G&rft.aulast=Davis&rft.aufirst=CH&rft.date=2007-09-01&rft.volume=26&rft.issue=2&rft.spage=409&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Graphics+and+Modelling&rft.issn=10933263&rft_id=info:doi/10.1016%2Fj.jmgm.2006.10.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Epoxides; Hydroquinone; Energy transduction; Enzymes; Hydrogen; Free energy; Models; Oxygen; Carbon; Ham; Oxidation; Vitamin K; Glutamic acid DO - http://dx.doi.org/10.1016/j.jmgm.2006.10.006 ER - TY - JOUR T1 - Nelfinavir, A Lead HIV Protease Inhibitor, Is a Broad-Spectrum, Anticancer Agent that Induces Endoplasmic Reticulum Stress, Autophagy, and Apoptosis In vitro and In vivo AN - 20696730; 7556263 AB - PURPOSE: The development of new cancer drugs is slow and costly. HIV protease inhibitors are Food and Drug Administration approved for HIV patients. Because these drugs cause toxicities that can be associated with inhibition of Akt, an emerging target in cancer, we assessed the potential of HIV protease inhibitors as anticancer agents. Experimental Design: HIV protease inhibitors were screened in vitro using assays that measure cellular proliferation, apoptotic and nonapoptotic cell death, endoplasmic reticulum (ER) stress, autophagy, and activation of Akt. Nelfinavir was tested in non-small cell lung carcinoma (NSCLC) xenografts with biomarker assessment. RESULTS: Three of six HIV protease inhibitors, nelfinavir, ritonavir, and saquinavir, inhibited proliferation of NSCLC cells, as well as every cell line in the NCI60 cell line panel. Nelfinavir was most potent with a mean 50% growth inhibition of 5.2 mu mol/L, a concentration achievable in HIV patients. Nelfinavir caused two types of cell death, caspase-dependent apoptosis and caspase-independent death that was characterized by induction of ER stress and autophagy. Autophagy was protective because an inhibitor of autophagy increased nelfinavir-induced death. Akt was variably inhibited by HIV protease inhibitors, but nelfinavir caused the greatest inhibition of endogenous and growth factor-induced Akt activation. Nelfinavir decreased the viability of a panel of drug-resistant breast cancer cell lines and inhibited the growth of NSCLC xenografts that was associated with induction of ER stress, autophagy, and apoptosis. CONCLUSIONS: Nelfinavir is a lead HIV protease inhibitor with pleiotropic effects in cancer cells. Given its wide spectrum of activity, oral availability, and familiarity of administration, nelfinavir is a Food and Drug Administration-approved drug that could be repositioned as a cancer therapeutic. JF - Clinical Cancer Research AU - Gills, Joell J AU - LoPiccolo, Jaclyn AU - Tsurutani, Junji AU - Shoemaker, Robert H AU - Best, Carolyn JM AU - Abu-Asab, Mones S AU - Borojerdi, Jennifer AU - Warfel, Noel A AU - Gardner, Erin R AU - Danish, Matthew AU - Hollander, MChristine AU - Kawabata, Shigeru AU - Tsokos, Maria AU - Figg, William D AU - Steeg, Patricia S AU - Dennis, Phillip A AD - Authors' Affiliations: Medical Oncology Branch, Molecular Therapeutics Program, Laboratory of Pathology, Clinical Pharmacology Program, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - 5183 EP - 5194 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 13 IS - 17 SN - 1078-0432, 1078-0432 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Apoptosis KW - Saquinavir KW - Drug resistance KW - Non-small cell lung carcinoma KW - Proteinase inhibitors KW - Stress KW - Drug development KW - Toxicity KW - Familiarity KW - biomarkers KW - Antitumor agents KW - Lead KW - Endoplasmic reticulum KW - Tumor cell lines KW - Human immunodeficiency virus KW - Ritonavir KW - AKT protein KW - Breast cancer KW - Xenografts KW - Phagocytosis KW - Nelfinavir KW - Cell proliferation KW - V 22360:AIDS and HIV KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20696730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Nelfinavir%2C+A+Lead+HIV+Protease+Inhibitor%2C+Is+a+Broad-Spectrum%2C+Anticancer+Agent+that+Induces+Endoplasmic+Reticulum+Stress%2C+Autophagy%2C+and+Apoptosis+In+vitro+and+In+vivo&rft.au=Gills%2C+Joell+J%3BLoPiccolo%2C+Jaclyn%3BTsurutani%2C+Junji%3BShoemaker%2C+Robert+H%3BBest%2C+Carolyn+JM%3BAbu-Asab%2C+Mones+S%3BBorojerdi%2C+Jennifer%3BWarfel%2C+Noel+A%3BGardner%2C+Erin+R%3BDanish%2C+Matthew%3BHollander%2C+MChristine%3BKawabata%2C+Shigeru%3BTsokos%2C+Maria%3BFigg%2C+William+D%3BSteeg%2C+Patricia+S%3BDennis%2C+Phillip+A&rft.aulast=Gills&rft.aufirst=Joell&rft.date=2007-09-01&rft.volume=13&rft.issue=17&rft.spage=5183&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Apoptosis; Saquinavir; Drug resistance; Proteinase inhibitors; Non-small cell lung carcinoma; Stress; Drug development; Toxicity; Familiarity; Antitumor agents; biomarkers; Lead; Endoplasmic reticulum; Tumor cell lines; Ritonavir; AKT protein; Breast cancer; Xenografts; Cell proliferation; Nelfinavir; Phagocytosis; Human immunodeficiency virus ER - TY - JOUR T1 - Risk of human T-lymphotropic virus type I-associated diseases in Jamaica with common HLA types AN - 20679245; 8079587 AB - Human T-lymphotropic virus-I (HTLV-I) causes adult T-cell leukemia/lymphoma (ATL) and HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). We postulated a higher disease risk for people with common human leukocyte antigen (HLA) types, due to a narrower immune response against viral or neoplastic antigens, compared to people with uncommon types. HLA class-I (A,B) and class-II (DRB1, DQB1) allele and haplotype frequencies in 56 ATL patients, 59 HAM/TSP patients and 190 population-based, asymptomatic HTLV-I-infected carriers were compared by logistic regression overall (score test) and with odds ratios (ORs) for common types (prevalence >50% of asymptomatic carriers) and by prevalence quartile. HTLV-I proviral load between asymptomatic carriers with common versus uncommon types was compared by t-test. ATL differed from asymptomatic carriers in overall DQB1 allele and class-I haplotype frequencies (p 0.04). ATL risk was increased significantly with common HLA-B (OR 2.25, 95% CI 1.19-4.25) and DRB1 (OR 2.11, 95% CI 1.13-3.40) alleles. Higher prevalence HLA-B alleles were associated with higher ATL risk (OR 1.14 per quartile, ptrend = 0.02). Asymptomatic carriers with common HLA-B alleles had marginally higher HTLV-I proviral load (p = 0.057). HAM/TSP risk did not differ consistently with common HLA types. Thus, ATL risk, but not HAM/TSP risk, was increased with higher prevalence HLA-B alleles. Perhaps breadth of cellular immunity affects risk of this viral leukemia/lymphoma. JF - International Journal of Cancer AU - Goedert, James J AU - Li, Hong-Chuan AU - Gao, Xiao-Jiang AU - Chatterjee, Nilanjan AU - Sonoda, Shunro AU - Biggar, Robert J AU - Cranston, Beverley AU - Kim, Norma AU - Carrington, Mary AU - Morgan, Owen AU - Hanchard, Barrie AU - Hisada, Michie AD - Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, goedertj@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 1092 EP - 1097 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 121 IS - 5 SN - 0020-7136, 0020-7136 KW - Virology & AIDS Abstracts; Risk Abstracts; Immunology Abstracts KW - Histocompatibility antigen HLA KW - ASW, Greater Antilles, Jamaica KW - Spinal cord KW - Human T-lymphotropic virus 1 KW - haplotypes KW - Cancer KW - Leukemia KW - Haplotypes KW - Immunity (cell-mediated) KW - Risk factors KW - Tropical spastic paraparesis KW - Central nervous system diseases KW - Lymphocytes T KW - Gene frequency KW - Immune response KW - lymphoma KW - Lymphoma KW - V 22350:Immunology KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20679245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Risk+of+human+T-lymphotropic+virus+type+I-associated+diseases+in+Jamaica+with+common+HLA+types&rft.au=Goedert%2C+James+J%3BLi%2C+Hong-Chuan%3BGao%2C+Xiao-Jiang%3BChatterjee%2C+Nilanjan%3BSonoda%2C+Shunro%3BBiggar%2C+Robert+J%3BCranston%2C+Beverley%3BKim%2C+Norma%3BCarrington%2C+Mary%3BMorgan%2C+Owen%3BHanchard%2C+Barrie%3BHisada%2C+Michie&rft.aulast=Goedert&rft.aufirst=James&rft.date=2007-09-01&rft.volume=121&rft.issue=5&rft.spage=1092&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22767 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Leukemia; Immunity (cell-mediated); Haplotypes; Spinal cord; Tropical spastic paraparesis; Risk factors; Central nervous system diseases; Lymphocytes T; Gene frequency; Immune response; Lymphoma; haplotypes; lymphoma; Cancer; Human T-lymphotropic virus 1; ASW, Greater Antilles, Jamaica DO - http://dx.doi.org/10.1002/ijc.22767 ER - TY - JOUR T1 - Variation in breast cancer hormone receptor and HER2 levels by etiologic factors: A population-based analysis AN - 20649127; 8079585 AB - Evidence suggests that breast cancer hormone receptor status varies by etiologic factors, but studies have been inconsistent. In a population-based case-control study in Poland that included 2,386 cases and 2,502 controls, we assessed ER- and PR status of tumors based on clinical records according to etiologic exposure data collected via interview. For 842 cancers, we evaluated ER-, ER-, PR and HER2 levels by semiquantitative microscopic scoring of immunostained tissue microarrays and a quantitative immunofluorescence method, automated quantitative analysis (AQUATM). We related marker levels in tumors to etiologic factors, using standard regression models and novel statistical methods, permitting adjustment for both correlated tumor features and exposures. Results obtained with different assays were generally consistent. Receptor levels varied most significantly with body mass index (BMI), a factor that was inversely related to risk among premenopausal women and directly related to risk among postmenopausal women with larger tumors. After adjustment for correlated markers, exposures and pathologic characteristics, PR and HER2 AQUA levels were inversely related to BMI among premenopausal women (p-trend = 0.01, both comparisons), whereas among postmenopausal women, PR levels were associated directly with BMI (p-trend = 0.002). Among postmenopausal women, analyses demonstrated that BMI was related to an interaction of PR and HER2: odds ratio (OR) = 0.86 (95% CI = 0.69-1.07) for low PR and HER2 expression vs. OR = 1.78 (95% CI = 1.25-2.55) for high expression (p-heterogeneity = 0.001). PR and HER2 levels in breast cancer vary by BMI, suggesting a heterogeneous etiology for tumors related to these markers. JF - International Journal of Cancer AU - Sherman, Mark E AU - Rimm, David L AU - Yang, Xiaohong R AU - Chatterjee, Nilanjan AU - Brinton, Louise A AU - Lissowska, Jolanta AU - Peplonska, Beata AU - Szeszenia-Dabrowska, Neonila AU - Zatonski, Witold AU - Cartun, Richard AU - Mandich, Daniza AU - Rymkiewicz, Grzegorz AU - Ligaj, Marcin AU - Lukaszek, Stanislaw AU - Kordek, Radzislaw AU - Kalaylioglu, Zynep AU - Harigopal, Malini AU - Charrette, Lori AU - Falk, Roni T AU - Richesson, Douglas AU - Anderson, William F AU - Hewitt, Stephen M AU - Garcia-Closas, Montserrat AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, shermanm@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 1079 EP - 1085 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 121 IS - 5 SN - 0020-7136, 0020-7136 KW - Risk Abstracts; Oncogenes & Growth Factors Abstracts KW - Etiology KW - ErbB-2 protein KW - Mathematical models KW - post-menopause KW - Statistical analysis KW - Tumors KW - Immunofluorescence KW - Hormones KW - Models KW - body mass KW - Post-menopause KW - Poland KW - Regression analysis KW - Breast cancer KW - Body mass index KW - B 26660:Miscellaneous Oncogenes & Growth Factors KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20649127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Variation+in+breast+cancer+hormone+receptor+and+HER2+levels+by+etiologic+factors%3A+A+population-based+analysis&rft.au=Sherman%2C+Mark+E%3BRimm%2C+David+L%3BYang%2C+Xiaohong+R%3BChatterjee%2C+Nilanjan%3BBrinton%2C+Louise+A%3BLissowska%2C+Jolanta%3BPeplonska%2C+Beata%3BSzeszenia-Dabrowska%2C+Neonila%3BZatonski%2C+Witold%3BCartun%2C+Richard%3BMandich%2C+Daniza%3BRymkiewicz%2C+Grzegorz%3BLigaj%2C+Marcin%3BLukaszek%2C+Stanislaw%3BKordek%2C+Radzislaw%3BKalaylioglu%2C+Zynep%3BHarigopal%2C+Malini%3BCharrette%2C+Lori%3BFalk%2C+Roni+T%3BRichesson%2C+Douglas%3BAnderson%2C+William+F%3BHewitt%2C+Stephen+M%3BGarcia-Closas%2C+Montserrat&rft.aulast=Sherman&rft.aufirst=Mark&rft.date=2007-09-01&rft.volume=121&rft.issue=5&rft.spage=1079&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22812 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Etiology; Mathematical models; ErbB-2 protein; Post-menopause; Regression analysis; Statistical analysis; Breast cancer; Immunofluorescence; Tumors; Body mass index; Hormones; Models; post-menopause; body mass; Poland DO - http://dx.doi.org/10.1002/ijc.22812 ER - TY - JOUR T1 - Sorting of transgenic secretory proteins in miniature pig parotid glands following adenoviral-mediated gene transfer AN - 20645529; 8029077 AB - Background Gene transfer to salivary glands for use in treating both systemic and upper gastrointestinal tract diseases shows considerable potential. Numerous studies in rodents demonstrate that salivary glands can secrete transgenic secretory proteins either into saliva, primarily via the regulated secretory pathway (RSP), or into the bloodstream, primarily by the constitutive secretory pathway (CSP). The purpose of the present study was to assess the sorting characteristics of human growth hormone (hGH), a RSP protein, and human erythropoietin (hEpo), a CSP protein, in a large animal model of salivary gland gene transfer, the miniature pig. Methods Recombinant serotype 5 adenoviral (Ad5; 1011 particles/gland) vectors encoding either hGH (AdCMVhGH) or hEpo (AdCMVhEpo) were administered to both parotid glands of male miniature pigs by intraductal cannulation. The secretion of hGH or hEpo was measured in both saliva and serum on days 3, 7 and 14 following administration. Detailed serum chemistry and hematological analyses were performed, and the presence of serum antibodies to hGH and hEpo was measured. For AdCMVhEpo-treated minipigs vector distribution in multiple tissues was determined by quantitative polymerase chain reaction (QPCR). Results The RSP protein hGH was secreted entirely into saliva, while the CSP protein hEpo was secreted into both saliva and serum. Most hEpo was found in saliva, but serum hEpo levels were sufficient to significantly increase hematocrit levels in treated animals by 10%. Expression of both transgenes was maximal on day 3 and declined to near background by day 14. The amount of vector found in the targeted glands was 100X more than in other tissues. Conclusions Secretion of transgenic hGH from minipig parotid glands occurred principally into saliva via the RSP, as seen in rodents, while hEpo was secreted into both saliva and serum, the latter presumably via the CSP. Even though hEpo secretion into the bloodstream was not to the extent previously observed in rodents, serum hEpo levels were considerable and the hEpo was biologically active. Ad5 vector distribution was highly restricted to the parotid glands with little vector detected elsewhere. While the results in this large animal model support the established notion that salivary gland gene transfer can be used for treating systemic single protein deficiency disorders, they also highlight differences in transgenic CSP protein sorting between rodents and miniature pigs. JF - Journal of Gene Medicine AU - Yan, Xing AU - Voutetakis, Antonis AU - Zheng, Changyu AU - Hai, Bo AU - Zhang, Chunmei AU - Baum, Bruce J AU - Wang, Songlin AD - Salivary Gland Disease Center and the Molecular Laboratory for Gene Therapy, School of Stomatology, Capital Medical University, Beijing 100050, P.R. China, bbaum@dir.nidcr.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 779 EP - 787 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 9 IS - 9 SN - 1099-498X, 1099-498X KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Growth hormone KW - Serotypes KW - Gastrointestinal tract diseases KW - Secretion KW - Parotid gland KW - Animal models KW - CSP protein KW - Salivary gland KW - Expression vectors KW - Antibodies KW - Erythropoietin KW - Gene transfer KW - Protein deficiency KW - Hematocrit KW - Polymerase chain reaction KW - Saliva KW - Cannulation KW - W 30925:Genetic Engineering KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20645529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=A+pharmacokinetic+and+safety+evaluation+of+an+episcleral+cyclosporine+implant+for+potential+use+in+high-risk+keratoplasty+rejection.&rft.au=Lee%2C+Susan+S%3BKim%2C+Hyuncheol%3BWang%2C+Nam+Sun%3BBungay%2C+Peter+M%3BGilger%2C+Brian+C%3BYuan%2C+Peng%3BKim%2C+Jonghyeon%3BCsaky%2C+Karl+G%3BRobinson%2C+Michael+R&rft.aulast=Lee&rft.aufirst=Susan&rft.date=2007-05-01&rft.volume=48&rft.issue=5&rft.spage=2023&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=01460404&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Growth hormone; Serotypes; Secretion; Gastrointestinal tract diseases; Parotid gland; CSP protein; Animal models; Salivary gland; Expression vectors; Antibodies; Erythropoietin; Gene transfer; Protein deficiency; Polymerase chain reaction; Hematocrit; Saliva; Cannulation DO - http://dx.doi.org/10.1002/jgm.1081 ER - TY - JOUR T1 - Phosphoproteomics for the discovery of kinases as cancer biomarkers and drug targets AN - 20634983; 7732069 AB - Early detection and targeted therapy represent a novel regimen of cancer management The understanding of receptor tyrosine kinases in tumorigenesis at the molecular level has led to the first generation of kinase inhibitors for anticancer therapy that targets a specific kinase or pathway. While the therapeutic advantage is obvious, targeted therapy often relapses and results in drug resistance for advanced cancers. To achieve feasible early detection and better efficacy of therapeutics targeting multiple pathways, significantly more biomarkers and drug targets are in demand, especially for individualized therapy. Recent advances in phosphoprotein enrichment and MS technologies for quantitative phosphoproteome analysis provide great opportunities in the identification and validation of kinases as drug targets. The MS-based phosphoproteomic technologies would be useful tools as well for the identification of phosphosignatures unique to a specific type or subtype of cancer and drug responsive biomarkers. This review summarizes the major kinases acting as cancer biomarkers and drug targets, the advances of MS-based phosphoproteomic technologies, and some potential values and challenges of this emerging phos-phoproteomics-based biomarker and drug target discovery field. Strategies for global, targeted, and quantitative phosphoproteomics are discussed, and some recent interesting applications are also evaluated. JF - Proteomics Clinical Applications AU - Yu, L-R AU - Issaq, HJ AU - Veenstra, T D AD - SAIC-Frederick, Inc., NCI-Frederick, P.O. Box B, Bldg. 434, Rm. 5E, Frederick, MD 21702, USA, lyu@ncifcrf.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 1042 EP - 1057 VL - 1 IS - 9 SN - 1862-8346, 1862-8346 KW - Biotechnology Research Abstracts (through 1992) KW - Drug discovery KW - Phosphoproteins KW - Drug resistance KW - Reviews KW - Tumorigenesis KW - phosphoproteomes KW - Protein-tyrosine kinase receptors KW - proteomics KW - biomarkers KW - Cancer KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20634983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics+Clinical+Applications&rft.atitle=Phosphoproteomics+for+the+discovery+of+kinases+as+cancer+biomarkers+and+drug+targets&rft.au=Yu%2C+L-R%3BIssaq%2C+HJ%3BVeenstra%2C+T+D&rft.aulast=Yu&rft.aufirst=L-R&rft.date=2007-09-01&rft.volume=1&rft.issue=9&rft.spage=1042&rft.isbn=&rft.btitle=&rft.title=Proteomics+Clinical+Applications&rft.issn=18628346&rft_id=info:doi/10.1002%2Fprca.200700102 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - biomarkers; Cancer; Drug discovery; Reviews; Protein-tyrosine kinase receptors; proteomics; Tumorigenesis; phosphoproteomes; Phosphoproteins; Drug resistance DO - http://dx.doi.org/10.1002/prca.200700102 ER - TY - JOUR T1 - Risk of Testicular Germ Cell Cancer in Relation to Childhood Physical Activity AN - 20559763; 9271161 JF - Annals of Epidemiology AU - Cook, M B AU - Zhang, Y AU - Graubard, B I AU - Rubertone, M V AU - Erickson, R L AU - McGlynn, K A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 748 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 17 IS - 9 SN - 1047-2797, 1047-2797 KW - Physical Education Index KW - Epidemiology KW - Exercise KW - Cancer KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20559763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Biliary+tract+cancer+and+stones+in+relation+to+chronic+liver+conditions%3A+A+population-based+study+in+Shanghai%2C+China&rft.au=Hsing%2C+Ann+W%3BGao%2C+Yu-Tang%3BMcGlynn%2C+Katherine+A%3BNiwa%2C+Shelley%3BZhang%2C+Mingdong%3BHan%2C+Tian-Quan%3BWang%2C+Bing-Sheng%3BChen%2C+Jinbo%3BSakoda%2C+Lori+C%3BShen%2C+Ming-Chang%3BZhang%2C+Bai-He%3BDeng%2C+Jie%3BRashid%2C+Asif&rft.aulast=Hsing&rft.aufirst=Ann&rft.date=2007-05-01&rft.volume=120&rft.issue=9&rft.spage=1981&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22375 LA - English DB - Physical Education Index N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Epidemiology; Exercise; Cancer ER - TY - JOUR T1 - Rac interacts with Abi-1 and WAVE2 to promote an Arp23-dependent actin recruitment during chlamydial invasion AN - 20552171; 7894428 AB - Chlamydiae are Gram-negative obligate intracellular pathogens to which access to an intracellular environment is fundamental to their development. Chlamydial attachment to host cells induces the activation of the Rac GTPase, which is required for the localization of WAVE2 at the sites of chlamydial entry. Co-immunoprecipitation experiments demonstrated that Chlamydia trachomatis infection promoted the interaction of Rac with WAVE2 and Abi-1, but not with IRSp53. siRNA depletion of WAVE2 and Abi-1 abrogated chlamydia-induced actin recruitment and significantly reduced the uptake of the pathogen by the depleted cells. Chlamydia invasion also requires the Arp23 complex as demonstrated by its localization to the sites of chlamydial attachment and the reduced efficiency of chlamydial invasion in cells overexpressing the VCA domain of the neural Wiskott-Aldrich syndrome protein. Thus, C. trachomatis activates Rac and promotes its interaction with WAVE2 and Abi-1 to activate the Arp23 complex resulting in the induction of actin cytoskeletal rearrangements that are required for invasion. JF - Cellular Microbiology AU - Carabeo, Rey A AU - Dooley, Cheryl A AU - Grieshaber, Scott S AU - Hackstadt, Ted AD - Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY, USA., Ted_Hackstadt@NIH.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 2278 EP - 2288 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 9 IS - 9 SN - 1462-5814, 1462-5814 KW - Microbiology Abstracts B: Bacteriology KW - Cytoskeleton KW - siRNA KW - N-WASP protein KW - Chlamydia trachomatis KW - Actin KW - Pathogens KW - Development KW - Infection KW - Guanosinetriphosphatase KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20552171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+Microbiology&rft.atitle=Rac+interacts+with+Abi-1+and+WAVE2+to+promote+an+Arp23-dependent+actin+recruitment+during+chlamydial+invasion&rft.au=Carabeo%2C+Rey+A%3BDooley%2C+Cheryl+A%3BGrieshaber%2C+Scott+S%3BHackstadt%2C+Ted&rft.aulast=Carabeo&rft.aufirst=Rey&rft.date=2007-09-01&rft.volume=9&rft.issue=9&rft.spage=2278&rft.isbn=&rft.btitle=&rft.title=Cellular+Microbiology&rft.issn=14625814&rft_id=info:doi/10.1111%2Fj.1462-5822.2007.00958.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cytoskeleton; siRNA; N-WASP protein; Actin; Development; Pathogens; Infection; Guanosinetriphosphatase; Chlamydia trachomatis DO - http://dx.doi.org/10.1111/j.1462-5822.2007.00958.x ER - TY - JOUR T1 - Process optimization of large-scale production of recombinant adeno-associated vectors using dielectric spectroscopy AN - 20522365; 7623482 AB - A well-characterized manufacturing process for the large-scale production of recombinant adeno-associated vectors (rAAV) for gene therapy applications is required to meet current and future demands for pre-clinical and clinical studies and potential commercialization. Economic considerations argue in favor of suspension culture-based production. Currently, the only feasible method for large-scale rAAV production utilizes baculovirus expression vectors and insect cells in suspension cultures. To maximize yields and achieve reproducibility between batches, online monitoring of various metabolic and physical parameters is useful for characterizing early stages of baculovirus-infected insect cells. In this study, rAAVs were produced at 40-l scale yielding ~1 x 10 super(15) particles. During the process, dielectric spectroscopy was performed by real time scanning in radio frequencies between 300 kHz and 10 MHz. The corresponding permittivity values were correlated with the rAAV production. Both infected and uninfected reached a maximum value; however, only infected cell cultures permittivity profile reached a second maximum value. This effect was correlated with the optimal harvest time for rAAV production. Analysis of rAAV indicated the harvesting time around 48 h post-infection (hpi), and 72 hpi produced similar quantities of biologically active rAAV. Thus, if operated continuously, the 24-h reduction in the production process of rAAV gives sufficient time for additional 18 runs a year corresponding to an extra production of ~2 x 10 super(16) particles. As part of large-scale optimization studies, this new finding will facilitate the bioprocessing scale-up of rAAV and other bioproducts. JF - Applied Microbiology and Biotechnology AU - Negrete, Alejandro AU - Esteban, Geoffrey AU - Kotin, Robert M AD - US National Institutes of Health, 10 Center Drive, NIH, Building 10, Room 7D05, Bethesda, MD, 20892, USA, kotinr@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 761 EP - 772 PB - Springer-Verlag, Heidelberger Platz 3 Berlin 14197 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 76 IS - 4 SN - 0175-7598, 0175-7598 KW - Biotechnology and Bioengineering Abstracts KW - Expression vectors KW - Scanning KW - Gene therapy KW - Insect cells KW - Economics KW - Cell culture KW - Suspension culture KW - Baculovirus KW - Spectroscopy KW - Harvesting KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20522365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Microbiology+and+Biotechnology&rft.atitle=Process+optimization+of+large-scale+production+of+recombinant+adeno-associated+vectors+using+dielectric+spectroscopy&rft.au=Negrete%2C+Alejandro%3BEsteban%2C+Geoffrey%3BKotin%2C+Robert+M&rft.aulast=Negrete&rft.aufirst=Alejandro&rft.date=2007-09-01&rft.volume=76&rft.issue=4&rft.spage=761&rft.isbn=&rft.btitle=&rft.title=Applied+Microbiology+and+Biotechnology&rft.issn=01757598&rft_id=info:doi/10.1007%2Fs00253-007-1030-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Expression vectors; Gene therapy; Scanning; Insect cells; Economics; Suspension culture; Cell culture; Spectroscopy; Harvesting; Baculovirus DO - http://dx.doi.org/10.1007/s00253-007-1030-9 ER - TY - JOUR T1 - Aegyptin, a Novel Mosquito Salivary Gland Protein, Specifically Binds to Collagen and Prevents Its Interaction with Platelet Glycoprotein VI, Integrin alpha 2 beta 1, and von Willebrand Factor AN - 20463564; 7613880 AB - Blood-sucking arthropods have evolved a number of inhibitors of platelet aggregation and blood coagulation. In this study we have molecularly and functionally characterized aegyptin, a member of the family of 30-kDa salivary allergens from Aedes aegypti, whose function remained elusive thus far. Aegyptin displays a unique sequence characterized by glycine, glutamic acid, and aspartic acid repeats and was shown to specifically block collagen-induced human platelet aggregation and granule secretion. Plasmon resonance experiments demonstrate that aegyptin binds to collagen types I-V (K sub(d) approximately 1 nM) but does not interact with vitronectin, fibronectin, laminin, fibrinogen, and von Willebrand factor (vWf). In addition, aegyptin attenuates platelet adhesion to soluble or fibrillar collagen. Furthermore, aegyptin inhibits vWf interaction with collagen type III under static conditions and completely blocks platelet adhesion to collagen under flow conditions at high shear rates. Notably, aegyptin prevents collagen but not convulxin binding to recombinant glycoprotein VI. These findings suggest that aegyptin recognizes specific binding sites for glycoprotein VI, integrin alpha 2 beta 1, and vWf, thereby preventing collagen interaction with its three major ligands. Aegyptin is a novel tool to study collagen-platelet interaction and a prototype for development of molecules with antithrombotic properties. JF - Journal of Biological Chemistry AU - Calvo, Eric AU - Tokumasu, Fuyuki AU - Marinotti, Osvaldo AU - Villeval, Jean-Luc AU - Ribeiro, Jose MC AU - Francischetti, Ivo MB AD - Vector Biology Section, and Biochemical and Biophysical Parasitology Section, Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Bethesda, Maryland 20892-8132, the Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697-3900, and INSERM, U790, Universite Paris XI, Institut Gustave Roussy, 94805 Villejuif, France Y1 - 2007/09// PY - 2007 DA - September 2007 SP - 26928 EP - 26938 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org] VL - 282 IS - 37 SN - 0021-9258, 0021-9258 KW - Yellow fever mosquito KW - Entomology Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Aedes aegypti KW - Von Willebrand factor KW - Aspartic acid KW - Platelet aggregation KW - Secretion KW - Collagen KW - Public health KW - Recombinants KW - Arthropoda KW - Integrins KW - glycoprotein VI KW - Allergens KW - Glands KW - vitronectin KW - Glycoproteins KW - Aquatic insects KW - Ligands KW - Q1 08306:Physiology, biochemistry, biophysics KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20463564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Aegyptin%2C+a+Novel+Mosquito+Salivary+Gland+Protein%2C+Specifically+Binds+to+Collagen+and+Prevents+Its+Interaction+with+Platelet+Glycoprotein+VI%2C+Integrin+alpha+2+beta+1%2C+and+von+Willebrand+Factor&rft.au=Calvo%2C+Eric%3BTokumasu%2C+Fuyuki%3BMarinotti%2C+Osvaldo%3BVilleval%2C+Jean-Luc%3BRibeiro%2C+Jose+MC%3BFrancischetti%2C+Ivo+MB&rft.aulast=Calvo&rft.aufirst=Eric&rft.date=2007-09-01&rft.volume=282&rft.issue=37&rft.spage=26928&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Recombinants; Secretion; Glands; Glycoproteins; Aquatic insects; Ligands; Public health; Von Willebrand factor; Aspartic acid; Integrins; Platelet aggregation; Allergens; glycoprotein VI; vitronectin; Collagen; Aedes aegypti; Arthropoda ER - TY - JOUR T1 - Role of the Proteasome in Ethanol-Induced Liver Pathology AN - 20418895; 7883795 AB - The ubiquitin-proteasome system has come to be known as a vital constituent of mammalian cells. The proteasome is a large nonlysosomal enzyme that acts in concert with an 8.5 kDa polypeptide called ubiquitin and a series of conjugating enzymes, known as E1, E2 and E3, that covalently bind multiple ubiquitin moieties in a polyubiquitin chain to protein substrates in a process called ubiquitylation. The latter process targets protein substrates for unfolding and degradation by the 26S proteasome. This enzyme system specifically recognizes and degrades polyubiquitylated proteins, many of which are key proteins involved in cell cycle regulation, apoptosis, signal transduction, and antigen presentation. The 26S proteasome contains a cylinder-shaped 20S catalytic core that, itself, degrades proteins in an ATP- and ubiquitin-independent manner. The 20S form is actually the predominant enzyme form in mammalian cells. Proteolysis by the constitutive 20S proteasome is vital in removing oxidized, misfolded and otherwise modified proteins. Such degradation is critical as a means of cellular detoxification, as intracellular accumulation of damaged and misfolded proteins is potentially lethal. Studies have shown that inhibition of proteasome activity can lead to cell death. Ethanol and its metabolism cause partial inhibition of the proteasome. This leads to a number of pleiotropic effects that can affect a variety of cellular processes. This critical review describes important aspects of ethanol metabolism and its influence on the proteasome. The review will summarize recent findings on: (1) the interactions between the proteasome and the ethanol metabolizing enzyme, CYP2E1; (2) the dynamics of proteasome inhibition by ethanol in animal models and cultured cells; (3) ethanol-elicited suppression of proteasome activity and its effect on signal transduction; (4) The role of proteasome inhibition in cytokine production by liver cells; and (5) ethanol elicited suppression of peptide hydrolysis and the potential effects on antigen presentation. While the principal focus is on alcohol-induced liver injury, the authors foresee that the findings presented in this review will prompt further research on the role of this proteolytic system in other tissues injured by excessive alcohol consumption. JF - Alcoholism: Clinical and Experimental Research AU - Donohue, Terrence M AU - Cederbaum, Arthur I AU - French, Samuel W AU - Barve, Shirish AU - Gao, Bin AU - Osna, Natalia A AD - From the Liver Study Unit Omaha VA Medical Center, and Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska (TMD, NAO); Departments of Pharmacology and Biological Chemistry, Mt. Sinai Medical Center, New York, New York (AIC); Department of Anatomic Pathology Harbor UCLA Medical Center, Torrance, California (SWF); Department of Internal Medicine, University of Louisville Medical Center, Louisville, Kentucky (SB); and Section of Liver Biology, National Institutes of Health, Bethesda, Maryland (BG). Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 1446 EP - 1459 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 31 IS - 9 SN - 0145-6008, 0145-6008 KW - Toxicology Abstracts KW - Ethanol Metabolism KW - Proteolysis KW - Ubiquitin Proteasome System KW - Alcoholic Liver Disease KW - Signal Transduction KW - Antigen Presentation KW - Detoxification KW - Apoptosis KW - Injuries KW - Hepatocytes KW - Cell cycle KW - proteasomes KW - Animal models KW - Enzymes KW - Antigen presentation KW - Drug abuse KW - Hydrolysis KW - Mammalian cells KW - Protein folding KW - Reviews KW - Alcoholism KW - Liver KW - Cytokines KW - Metabolism KW - Signal transduction KW - Ubiquitin KW - Ethanol KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20418895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%3A+Clinical+and+Experimental+Research&rft.atitle=Role+of+the+Proteasome+in+Ethanol-Induced+Liver+Pathology&rft.au=Donohue%2C+Terrence+M%3BCederbaum%2C+Arthur+I%3BFrench%2C+Samuel+W%3BBarve%2C+Shirish%3BGao%2C+Bin%3BOsna%2C+Natalia+A&rft.aulast=Donohue&rft.aufirst=Terrence&rft.date=2007-09-01&rft.volume=31&rft.issue=9&rft.spage=1446&rft.isbn=&rft.btitle=&rft.title=Alcoholism%3A+Clinical+and+Experimental+Research&rft.issn=01456008&rft_id=info:doi/10.1111%2Fj.1530-0277.2007.00454.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Detoxification; Proteolysis; Apoptosis; Injuries; Hepatocytes; Cell cycle; Animal models; proteasomes; Enzymes; Drug abuse; Antigen presentation; Hydrolysis; Protein folding; Mammalian cells; Reviews; Alcoholism; Liver; Cytokines; Metabolism; Ethanol; Ubiquitin; Signal transduction DO - http://dx.doi.org/10.1111/j.1530-0277.2007.00454.x ER - TY - JOUR T1 - Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy AN - 20410111; 7636230 AB - Annexin V and Sytox Green are widely used markers to evaluate apoptosis in various cell types using flow cytometry and fluorescent microscopy. Recently, a novel fluoroprobe MitoSOX Red was introduced for selective detection of superoxide in the mitochondria of live cells and was validated for confocal microscopy and flow cytometry. This protocol describes simultaneous measurements of mitochondrial superoxide generation with apoptotic markers (Annexin V and Sytox Green) by both flow cytometry and confocal microscopy in endothelial cell lines. The advantages of the described flow cytometry method over other cell-based techniques are the tremendous speed (1-2 h), exquisite precision and the possibility of simultaneous quantitative measurements of mitochondrial superoxide generation and apoptotic (and other) markers, with maximal preservation of cellular functions. This method combined with fluorescent microscopy may be very useful to reveal important spatial-temporal changes in mitochondrial superoxide production and execution of programmed cell death in virtually any cell type. JF - Nature Protocols AU - Mukhopadhyay, Partha AU - Rajesh, Mohanraj AU - Hasko, Gyoergy AU - Hawkins, Brian J AU - Madesh, Muniswamy AU - Pacher, Pal Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 2295 EP - 2301 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 2 IS - 9 SN - 1754-2189, 1754-2189 KW - Biotechnology Research Abstracts (through 1992) KW - Endothelial cells KW - Flow cytometry KW - Apoptosis KW - Superoxide KW - Confocal microscopy KW - Mitochondria KW - Preservation KW - Annexin V KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20410111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Protocols&rft.atitle=Simultaneous+detection+of+apoptosis+and+mitochondrial+superoxide+production+in+live+cells+by+flow+cytometry+and+confocal+microscopy&rft.au=Mukhopadhyay%2C+Partha%3BRajesh%2C+Mohanraj%3BHasko%2C+Gyoergy%3BHawkins%2C+Brian+J%3BMadesh%2C+Muniswamy%3BPacher%2C+Pal&rft.aulast=Mukhopadhyay&rft.aufirst=Partha&rft.date=2007-09-01&rft.volume=2&rft.issue=9&rft.spage=2295&rft.isbn=&rft.btitle=&rft.title=Nature+Protocols&rft.issn=17542189&rft_id=info:doi/10.1038%2Fnprot.2007.327 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Mitochondria; Apoptosis; Superoxide; Confocal microscopy; Annexin V; Preservation; Endothelial cells DO - http://dx.doi.org/10.1038/nprot.2007.327 ER - TY - JOUR T1 - Effects of manganese on thyroid hormone homeostasis: Potential links AN - 20405765; 7750857 AB - Manganese (Mn) is an essential trace nutrient that is potentially toxic at high levels of exposure. As a constituent of numerous enzymes and a cofactor, manganese plays an important role in a number of physiologic processes in mammals. The manganese-containing enzyme, manganese superoxide dismutase (Mn-SOD), is the principal antioxidant enzyme which neutralizes the toxic effects of reactive oxygen species. Other manganese-containing enzymes include oxidoreductases, transferases, hydrolases, lyases, isomerases, ligases and glutamine synthetase. Environmental or occupational exposure to high levels of manganese can cause a neuropathy resembling idiopathic Parkinson's disease, commonly referred to as manganism. Manganism and Parkinson's disease are both characterized by motor deficits and damage to nuclei of the basal ganglia, particularly the substantia nigra, with altered dopamine (and its metabolites) contributing to these disorders. Dopamine, a major neurotransmitter plays a crucial role in the modulation of the cognitive function, working memory and/or attention of the prefrontal cortex and the hippocampus. Dopamine is also a known inhibitory modulator of thyroid stimulating hormone (TSH) secretion. The involvement of dopamine and dopaminergic receptors in neurodevelopment, as well as TSH modulation, led us to hypothesize that excessive manganese exposure may lead to adverse neurodevelopmental outcomes due to the disruption of thyroid homeostasis via the loss of dopaminergic control of TSH regulation of thyroid hormones. This disruption may alter thyroid hormone levels, resulting in some of the deficits associated with gestational exposure to manganese. While the effects of manganese in adult populations are relatively well documented, comprehensive data on its neurodevelopmental effects are sparse. Given the importance of this topic, we review the potential participation of thyroid hormone dyshomeostasis in the neurodevelopmental effects of manganese positing the hypotheses that manganese may directly or indirectly affect thyroid function by injuring the thyroid gland or dysregulating dopaminergic modulation of thyroid hormone synthesis. JF - Neurotoxicology AU - Soldin, O P AU - Aschner, M AD - The Center for Study of Sex Differences, Georgetown University Medical Center, Washington, DC, and Obstetrics Pharmacology Research Unit, NICHD, USA, os35@georgetown.edu Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 951 EP - 956 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 28 IS - 5 SN - 0161-813X, 0161-813X KW - Health & Safety Science Abstracts; CSA Neurosciences Abstracts; Toxicology Abstracts KW - Antioxidants KW - Hippocampus KW - Parkinson's disease KW - Secretion KW - Nutrients KW - Metabolites KW - Homeostasis KW - Hormones KW - Short term memory KW - Thyroid hormones KW - Neuromodulation KW - Dopamine KW - Superoxide dismutase KW - Thyroid-stimulating hormone KW - Neurotransmitters KW - Manganese KW - Occupational exposure KW - Neuropathy KW - mammals KW - Substantia nigra KW - Thyroid KW - Enzymes KW - Toxicity KW - Glutamate-ammonia ligase KW - hydrolase KW - Oxygen KW - Neurodegenerative diseases KW - cognitive ability KW - Movement disorders KW - Cofactors KW - Cognitive ability KW - Reviews KW - oxidoreductase KW - Attention KW - Cortex (prefrontal) KW - Basal ganglia KW - N3 11028:Neuropharmacology & toxicology KW - H 1000:Occupational Safety and Health KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20405765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Effects+of+manganese+on+thyroid+hormone+homeostasis%3A+Potential+links&rft.au=Soldin%2C+O+P%3BAschner%2C+M&rft.aulast=Soldin&rft.aufirst=O&rft.date=2007-09-01&rft.volume=28&rft.issue=5&rft.spage=951&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2007.05.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Antioxidants; Hippocampus; Secretion; Parkinson's disease; Metabolites; Nutrients; Homeostasis; Short term memory; Thyroid hormones; Neuromodulation; Dopamine; Superoxide dismutase; Neurotransmitters; Thyroid-stimulating hormone; Manganese; Occupational exposure; Neuropathy; Substantia nigra; Enzymes; hydrolase; Glutamate-ammonia ligase; Neurodegenerative diseases; Cofactors; Movement disorders; Cognitive ability; Reviews; oxidoreductase; Attention; Basal ganglia; Cortex (prefrontal); mammals; Thyroid; Toxicity; Hormones; Oxygen; cognitive ability DO - http://dx.doi.org/10.1016/j.neuro.2007.05.003 ER - TY - JOUR T1 - Analysis of inflammatory biomarkers from tissue biopsies by chip-based immunoaffinity CE AN - 20402942; 7762902 AB - To aid in the biochemical analysis of human skin biopsies, a semiautomatic chip-based CE system has been developed for measuring inflammatory biomarkers in microdissected areas of the biopsy. Following solubilization of the dissected tissue, the desired biomarkers were isolated by immunoaffinity capture using a panel of 12 antibodies, immobilized on a disposable glass fiber disk, within the extraction port of the chip. The captured analytes were labeled with a 635nm light-emitting laser dye and electroeluted into the separation channel. Electrophoretic separation of all of the analytes was achieved in 2.2min with quantification of each peak being performed by online LIF detection and integration of each peak area. Comparison of the results obtained from the chip-based system to those obtained using commercially available high-sensitivity immunoassays demonstrated that the chip-based assay provides a fast, accurate procedure for studying the concentrations of inflammatory biomarkers in complex biological materials. The degree of accuracy and precision achieved by the chip-based CE is comparable to conventional immunoassays and the system is capable of analyzing circa six samples per hour. With the ever-expanding array of antibodies that are commercially available, this chip-based system can be applied to a wide variety of different biomedical analyses. JF - Electrophoresis AU - Phillips, Terry M AU - Wellner, Edward F AD - Nanoscale Immunodiagnostics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA, phillipt@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 3041 EP - 3048 PB - Wiley-VCH, Postfach 101161 Weinheim 69451 Germany, [mailto:info@wiley-vch.de], [URL:http://www.wiley-vch.de/publish/en/] VL - 28 IS - 17 SN - 0173-0835, 0173-0835 KW - Biotechnology and Bioengineering Abstracts KW - Fibers KW - Integration KW - Antibodies KW - Skin KW - Solubilization KW - Biochemical analysis KW - Lasers KW - Biopsy KW - Immunoassays KW - biomarkers KW - Inflammation KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20402942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Electrophoresis&rft.atitle=Analysis+of+inflammatory+biomarkers+from+tissue+biopsies+by+chip-based+immunoaffinity+CE&rft.au=Phillips%2C+Terry+M%3BWellner%2C+Edward+F&rft.aulast=Phillips&rft.aufirst=Terry&rft.date=2007-09-01&rft.volume=28&rft.issue=17&rft.spage=3041&rft.isbn=&rft.btitle=&rft.title=Electrophoresis&rft.issn=01730835&rft_id=info:doi/10.1002%2Felps.200700193 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - biomarkers; Biopsy; Inflammation; Antibodies; Immunoassays; Lasers; Biochemical analysis; Skin; Solubilization; Integration; Fibers DO - http://dx.doi.org/10.1002/elps.200700193 ER - TY - JOUR T1 - Potent Inhibition of HIV-1 Replication by Novel Non-peptidyl Small Molecule Inhibitors of Protease Dimerization AN - 20363392; 7614068 AB - Dimerization of HIV-1 protease subunits is essential for its proteolytic activity, which plays a critical role in HIV-1 replication. Hence, the inhibition of protease dimerization represents a unique target for potential intervention of HIV-1. We developed an intermolecular fluorescence resonance energy transfer-based HIV-1-expression assay employing cyan and yellow fluorescent protein-tagged protease monomers. Using this assay, we identified non-peptidyl small molecule inhibitors of protease dimerization. These inhibitors, including darunavir and two experimental protease inhibitors, blocked protease dimerization at concentrations of as low as 0.01 mu M and blocked HIV-1 replication with IC sub(50) values of 0.0002-0.48 mu M. These agents also inhibited the proteolytic activity of mature protease. Other approved anti-HIV-1 agents examined except tipranavir, a CCR5 inhibitor, and soluble CD4 failed to block the dimerization event. Once protease monomers dimerize to become mature protease, mature protease is not dissociated by this dimerization inhibition mechanism, suggesting that these agents block dimerization at the nascent stage of protease maturation. The proteolytic activity of mature protease that managed to undergo dimerization despite the presence of these agents is likely to be inhibited by the same agents acting as conventional protease inhibitors. Such a dual inhibition mechanism should lead to highly potent inhibition of HIV-1. JF - Journal of Biological Chemistry AU - Koh, Yasuhiro AU - Matsumi, Shintaro AU - Das, Debananda AU - Amano, Masayuki AU - Davis, David A AU - Li, Jianfeng AU - Leschenko, Sofiya AU - Baldridge, Abigail AU - Shioda, Tatsuo AU - Yarchoan, Robert AU - Ghosh, Arun K AU - Mitsuya, Hiroaki AD - Department of Hematology and Department of Infectious Diseases, Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, 1-1-1 Honjo, Kumamoto 860-8556, Japan, the Experimental Retrovirology Section and Retroviral Disease Section, HIV and AIDS Malignancy Branch, NCI, National Institutes of Health, Bethesda, Maryland 20892, the Departments of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907, and the Department of Viral Infections, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 28709 EP - 28720 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 39 SN - 0021-9258, 0021-9258 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Proteolysis KW - Fluorescence KW - Replication KW - Proteinase inhibitors KW - CCR5 protein KW - Monomers KW - CD4 antigen KW - Human immunodeficiency virus 1 KW - V 22360:AIDS and HIV KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20363392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Potent+Inhibition+of+HIV-1+Replication+by+Novel+Non-peptidyl+Small+Molecule+Inhibitors+of+Protease+Dimerization&rft.au=Koh%2C+Yasuhiro%3BMatsumi%2C+Shintaro%3BDas%2C+Debananda%3BAmano%2C+Masayuki%3BDavis%2C+David+A%3BLi%2C+Jianfeng%3BLeschenko%2C+Sofiya%3BBaldridge%2C+Abigail%3BShioda%2C+Tatsuo%3BYarchoan%2C+Robert%3BGhosh%2C+Arun+K%3BMitsuya%2C+Hiroaki&rft.aulast=Koh&rft.aufirst=Yasuhiro&rft.date=2007-09-01&rft.volume=282&rft.issue=39&rft.spage=28709&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus 1; Proteinase inhibitors; Replication; Proteolysis; Monomers; CD4 antigen; Fluorescence; CCR5 protein ER - TY - JOUR T1 - Characterization of Chimpanzee/Human Monoclonal Antibodies to Vaccinia Virus A33 Glycoprotein and Its Variola Virus Homolog In Vitro and in a Vaccinia Virus Mouse Protection Model AN - 20356285; 7559260 AB - Three distinct chimpanzee Fabs against the A33 envelope glycoprotein of vaccinia virus were isolated and converted into complete monoclonal antibodies (MAbs) with human gamma 1 heavy-chain constant regions. The three MAbs (6C, 12C, and 12F) displayed high binding affinities to A33 (K sub(d) of 0.14 nM to 20 nM) and may recognize the same epitope, which was determined to be conformational and located within amino acid residues 99 to 185 at the C terminus of A33. One or more of the MAbs were shown to reduce the spread of vaccinia virus as well as variola virus (the causative agent of smallpox) in vitro and to more effectively protect mice when administered before or 2 days after intranasal challenge with virulent vaccinia virus than a previously isolated mouse anti-A33 MAb (1G10) or vaccinia virus immunoglobulin. The protective efficacy afforded by anti-A33 MAb was comparable to that of a previously isolated chimpanzee/human anti-B5 MAb. The combination of anti-A33 MAb and anti-B5 MAb did not synergize the protective efficacy. These chimpanzee/human anti-A33 MAbs may be useful in the prevention and treatment of vaccinia virus-induced complications of vaccination against smallpox and may also be effective in the immunoprophylaxis and immunotherapy of smallpox and other orthopoxvirus diseases. JF - Journal of Virology AU - Chen, Zhaochun AU - Earl, Patricia AU - Americo, Jeffrey AU - Damon, Inger AU - Smith, Scott K AU - Yu, Fujuan AU - Sebrell, Andrew AU - Emerson, Suzanne AU - Cohen, Gary AU - Eisenberg, Roselyn J AU - Gorshkova, Inna AU - Schuck, Peter AU - Satterfield, William AU - Moss, Bernard AU - Purcell, Robert AD - Hepatitis Viruses Section. Molecular Hepatitis Section. Laboratory of Infectious Diseases, and Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases. Protein Biophysics Resource, National Institute for Biomedical Imaging and Bioengineering, NIH, Bethesda, Maryland 20892. Centers for Disease Control and Prevention, Atlanta, Georgia 30333. Department of Microbiology, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104. Department of Veterinary Sciences, University of Texas, M. D. Anderson Cancer Center, Bastrop, Texas 78602 Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - 8989 EP - 8995 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 81 IS - 17 SN - 0022-538X, 0022-538X KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Orthopoxvirus KW - Immunotherapy KW - Envelopes KW - Constant region KW - Glycoproteins KW - Immunoglobulins KW - Synergism KW - Amino acids KW - Vaccinia KW - Monoclonal antibodies KW - Vaccinia virus KW - Immunoprophylaxis KW - Animal models KW - Epitopes KW - Variola virus KW - Vaccination KW - Pan troglodytes KW - Smallpox KW - Fab KW - V 22410:Animal Diseases KW - W 30915:Pharmaceuticals & Vaccines KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20356285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Characterization+of+Chimpanzee%2FHuman+Monoclonal+Antibodies+to+Vaccinia+Virus+A33+Glycoprotein+and+Its+Variola+Virus+Homolog+In+Vitro+and+in+a+Vaccinia+Virus+Mouse+Protection+Model&rft.au=Chen%2C+Zhaochun%3BEarl%2C+Patricia%3BAmerico%2C+Jeffrey%3BDamon%2C+Inger%3BSmith%2C+Scott+K%3BYu%2C+Fujuan%3BSebrell%2C+Andrew%3BEmerson%2C+Suzanne%3BCohen%2C+Gary%3BEisenberg%2C+Roselyn+J%3BGorshkova%2C+Inna%3BSchuck%2C+Peter%3BSatterfield%2C+William%3BMoss%2C+Bernard%3BPurcell%2C+Robert&rft.aulast=Chen&rft.aufirst=Zhaochun&rft.date=2007-09-01&rft.volume=81&rft.issue=17&rft.spage=8989&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Vaccinia virus; Pan troglodytes; Variola virus; Orthopoxvirus; Monoclonal antibodies; Smallpox; Glycoproteins; Amino acids; Immunotherapy; Synergism; Fab; Immunoprophylaxis; Animal models; Epitopes; Vaccinia; Immunoglobulins; Constant region; Vaccination; Envelopes ER - TY - JOUR T1 - Genetic contributions to white matter architecture revealed by diffusion tensor imaging in Williams syndrome AN - 20338177; 7616787 AB - Little is known about genetic regulation of the development of white matter. This knowledge is critical in understanding the pathophysiology of neurodevelopmental syndromes associated with altered cognition as well as in elucidating the genetics of normal human cognition. The hemideletion of approximately 25 genes on chromosome 7q11.23 that causes Williams syndrome (WS) includes genes that regulate cytoskeletal dynamics in neurons, especially LIMK1 and CYLN2, and therefore offers the opportunity to investigate the role of these genes in the formation of white matter tracts. We used diffusion tensor imaging to demonstrate alteration in white matter fiber directionality, deviation in posterior fiber tract course, and reduced lateralization of fiber coherence in WS. These abnormalities are consistent with an alteration of the late stages of neuronal migration, define alterations of white matter structures underlying dissociable behavioral phenotypes in WS, and provide human in vivo information about genetic control of white matter tract formation. JF - Proceedings of the National Academy of Sciences, USA AU - Marenco, Stefano AU - Siuta, Michael A AU - Kippenhan, JShane AU - Grodofsky, Samuel AU - Chang, Wei-li AU - Kohn, Philip AU - Mervis, Carolyn B AU - Morris, Colleen A AU - Weinberger, Daniel R AU - Meyer-Lindenberg, Andreas AU - Pierpaoli, Carlo AU - Berman, Karen Faith AD - Clinical Brain Disorders Branch (CBDB), Genes Cognition and Psychosis Program (GCAP), Intramural Research Program (IRP), National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Department of Health and Human Services, Bethesda, MD 20892 Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 15117 EP - 15122 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 38 SN - 0027-8424, 0027-8424 KW - CSA Neurosciences Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Neurodevelopmental disorders KW - Magnetic resonance imaging KW - LIM kinase KW - Substantia alba KW - Cognition KW - chromosome 7 KW - Cytoskeleton KW - Fibers KW - Neurons KW - Genetic control KW - Cell migration KW - Williams syndrome KW - W 30910:Imaging KW - N3 11023:Neurogenetics KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20338177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Genetic+contributions+to+white+matter+architecture+revealed+by+diffusion+tensor+imaging+in+Williams+syndrome&rft.au=Marenco%2C+Stefano%3BSiuta%2C+Michael+A%3BKippenhan%2C+JShane%3BGrodofsky%2C+Samuel%3BChang%2C+Wei-li%3BKohn%2C+Philip%3BMervis%2C+Carolyn+B%3BMorris%2C+Colleen+A%3BWeinberger%2C+Daniel+R%3BMeyer-Lindenberg%2C+Andreas%3BPierpaoli%2C+Carlo%3BBerman%2C+Karen+Faith&rft.aulast=Marenco&rft.aufirst=Stefano&rft.date=2007-09-01&rft.volume=104&rft.issue=38&rft.spage=15117&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cytoskeleton; Neurodevelopmental disorders; Fibers; Neurons; LIM kinase; Magnetic resonance imaging; Substantia alba; Genetic control; Cell migration; Williams syndrome; Cognition; chromosome 7 ER - TY - JOUR T1 - The Structure of the R184A Mutant of the Inositol Monophosphatase Encoded by suhB and Implications for Its Functional Interactions in Escherichia coli AN - 20334202; 7613887 AB - The Escherichia coli product of the suhB gene, SuhB, is an inositol monophosphatase (IMPase) that is best known as a suppressor of temperature-sensitive growth phenotypes in E. coli. To gain insights into these biological diverse effects, we determined the structure of the SuhB R184A mutant protein. The structure showed a dimer organization similar to other IMPases, but with an altered interface suggesting that the presence of Arg-184 in the wild-type protein could shift the monomer-dimer equilibrium toward monomer. In parallel, a gel shift assay showed that SuhB forms a tight complex with RNA polymerase (RNA pol) that inhibits the IMPase catalytic activity of SuhB. A variety of SuhB mutant proteins designed to stabilize the dimer interface did not show a clear correlation with the ability of a specific mutant protein to complement the Delta suhB mutation when introduced extragenically despite being active IMPases. However, the loss of sensitivity to RNA pol binding, i.e. in G173V, R184I, and L96F/R184I, did correlate strongly with loss of complementation of Delta suhB. Because residue 184 forms the core of the SuhB dimer, it is likely that the interaction with RNA polymerase requires monomeric SuhB. The exposure of specific residues facilitates the interaction of SuhB with RNA pol (or another target with a similar binding surface) and it is this heterodimer formation that is critical to the ability of SuhB to rescue temperature-sensitive phenotypes in E. coli. JF - Journal of Biological Chemistry AU - Wang, Yanling AU - Stieglitz, Kimberly A AU - Bubunenko, Mikhail AU - Court, Donald L AU - Stec, Boguslaw AU - Roberts, Mary F AD - Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, the Basic Research Program, SAIC-Frederick, Inc. and the Molecular Control and Genetics Section, Gene Regulation and Chromosome Biology Laboratory, Center for Cancer Research, NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702, and The Burnham Institute for Medical Research, La Jolla, California 92037 Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 26989 EP - 26996 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 37 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Myo-inositol-1 (or 4)-monophosphatase KW - Monomers KW - DNA-directed RNA polymerase KW - Complementation KW - Escherichia coli KW - Mutation KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20334202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=The+Structure+of+the+R184A+Mutant+of+the+Inositol+Monophosphatase+Encoded+by+suhB+and+Implications+for+Its+Functional+Interactions+in+Escherichia+coli&rft.au=Wang%2C+Yanling%3BStieglitz%2C+Kimberly+A%3BBubunenko%2C+Mikhail%3BCourt%2C+Donald+L%3BStec%2C+Boguslaw%3BRoberts%2C+Mary+F&rft.aulast=Wang&rft.aufirst=Yanling&rft.date=2007-09-01&rft.volume=282&rft.issue=37&rft.spage=26989&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Monomers; Myo-inositol-1 (or 4)-monophosphatase; DNA-directed RNA polymerase; Complementation; Mutation; Escherichia coli ER - TY - JOUR T1 - Serum 25(OH)-Vitamin D Concentration and Risk of Esophageal Squamous Dysplasia AN - 20328525; 7610363 AB - Background: Squamous dysplasia is the precursor lesion for esophageal squamous cell carcinoma, and nutritional factors play an important role in the etiology of this cancer. Previous studies using a variety of measures for vitamin D exposure have reached different conclusions about the association between vitamin D and the risk of developing esophageal cancer. Methods: We measured serum 25-hydroxyvitamin D [25(OH)D] concentrations in a cross-sectional analysis of 720 subjects from Linxian, China, a population at high risk for developing esophageal squamous cell carcinoma. All subjects underwent endoscopy and biopsy and were categorized by the presence or absence of histologic squamous dysplasia. We used crude and multivariate-adjusted generalized linear models to estimate the relative risks (RR) and 95% confidence intervals (95% CI) for the association between squamous dysplasia and sex-specific quartiles of serum 25(OH)D concentration. Results: Two-hundred and thirty of 720 subjects (32%) had squamous dysplasia. Subjects with dysplasia had significantly higher median serum 25(OH)D concentrations than subjects without dysplasia, 36.5 and 31.5 nmol/L, respectively (Wilcoxon two-sample test, P = 0.0004). In multivariate-adjusted models, subjects in the highest compared with the lowest quartiles were at a significantly increased risk of squamous dysplasia (RR, 1.86; 95% CI, 1.35-2.62). Increased risks were similar when examined in men and women separately: men (RR, 1.74; 95% CI, 1.08-2.93); women (RR, 1.96; 95% CI, 1.28-3.18). Conclusions: Higher serum 25(OH)D concentrations were associated with significantly increased risk of squamous dysplasia. No obvious source of measured or unmeasured confounding explains this finding. (Cancer Epidemiol Biomarkers Prev 2007; 16(9):1889-93) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Abnet, Christian C AU - Chen, Wen AU - Dawsey, Sanford M AU - Wei, Wen-Qiang AU - Roth, Mark J AU - Liu, Bing AU - Lu, Ning AU - Taylor, Philip R AU - Qiao, You-Lin AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland and Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Beijing, People's Republic of China Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 1889 EP - 1893 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 9 SN - 1055-9965, 1055-9965 KW - Risk Abstracts KW - Etiology KW - vitamins KW - prevention KW - Supplements KW - Lesions KW - China, People's Rep. KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20328525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Serum+25%28OH%29-Vitamin+D+Concentration+and+Risk+of+Esophageal+Squamous+Dysplasia&rft.au=Abnet%2C+Christian+C%3BChen%2C+Wen%3BDawsey%2C+Sanford+M%3BWei%2C+Wen-Qiang%3BRoth%2C+Mark+J%3BLiu%2C+Bing%3BLu%2C+Ning%3BTaylor%2C+Philip+R%3BQiao%2C+You-Lin&rft.aulast=Abnet&rft.aufirst=Christian&rft.date=2007-09-01&rft.volume=16&rft.issue=9&rft.spage=1889&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Etiology; vitamins; prevention; Lesions; Supplements; Cancer; China, People's Rep. ER - TY - JOUR T1 - Gliotoxin Is a Virulence Factor of Aspergillus fumigatus: gliP Deletion Attenuates Virulence in Mice Immunosuppressed with Hydrocortisone AN - 20317820; 7612847 AB - Gliotoxin is an immunosuppressive mycotoxin long suspected to be a potential virulence factor of Aspergillus fumigatus. Recent studies using mutants lacking gliotoxin production, however, suggested that the mycotoxin is not important for pathogenesis of A. fumigatus in neutropenic mice resulting from treatment with cyclophosphomide and hydrocortisone. In this study, we report on the pathobiological role of gliotoxin in two different mouse strains, 129/Sv and BALB/c, that were immunosuppressed by hydrocortisone alone to avoid neutropenia. These strains of mice were infected using the isogenic set of a wild type strain (B-5233) and its mutant strain (gliP Delta ) and the the glip reconstituted strain (gliP sub(R)). The gliP gene encodes a nonribosomal peptide synthase that catalyzes the first step in gliotoxin biosynthesis. The gliP Delta strain was significantly less virulent than strain B-5233 or gliP sub(R) in both mouse models. In vitro assays with culture filtrates (CFs) of B-5233, gliP Delta , and gliP sub(R) strains showed the following: (i) deletion of gliP abrogated gliotoxin production, as determined by high-performance liquid chromatography analysis; (ii) unlike the CFs from strains B-5233 and gliP sub(R), gliP Delta CFs failed to induce proapoptotic processes in EL4 thymoma cells, as tested by Bak conformational change, mitochondrial-membrane potential disruption, superoxide production, caspase 3 activation, and phosphatidylserine translocation. Furthermore, superoxide production in human neutrophils was strongly inhibited by CFs from strain B-5233 and the gliP sub(R) strain, but not the gliP Delta strain. Our study confirms that gliotoxin is an important virulence determinant of A. fumigatus and that the type of immunosuppression regimen used is important to reveal the pathogenic potential of gliotoxin. JF - Eukaryotic Cell AU - Sugui, Janyce A AU - Pardo, Julian AU - Chang, Yun C AU - Zarember, Kol A AU - Nardone, Glenn AU - Galvez, Eva M AU - Muellbacher, Arno AU - Gallin, John I AU - Simon, Markus M AU - Kwon-Chung, Kyung J AD - Laboratory of Clinical Infectious Diseases. Laboratory of Host Defense. Research Technology Branch, National Institutes of Health, Bethesda, Maryland. Max-Planck-Institute for Immunology, Freiburg, Germany. Institut fuer Physikalische Chemie, Freiburg Universitaet, Freiburg, Germany. John Curtin School of Medical Research, Australian National University, Canberra, Australia Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 1562 EP - 1569 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 6 IS - 9 SN - 1535-9778, 1535-9778 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - High-performance liquid chromatography KW - Hydrocortisone KW - Apoptosis KW - virulence factors KW - Animal models KW - Leukocytes (neutrophilic) KW - Mitochondria KW - Cell culture KW - peptide synthase KW - Neutropenia KW - Mycotoxins KW - phosphatidylserine KW - Aspergillus fumigatus KW - Superoxide KW - Caspase-3 KW - BAK protein KW - gliotoxin KW - thymoma KW - Translocation KW - Immunosuppression KW - K 03410:Animal Diseases KW - F 06910:Microorganisms & Parasites KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20317820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eukaryotic+Cell&rft.atitle=Gliotoxin+Is+a+Virulence+Factor+of+Aspergillus+fumigatus%3A+gliP+Deletion+Attenuates+Virulence+in+Mice+Immunosuppressed+with+Hydrocortisone&rft.au=Sugui%2C+Janyce+A%3BPardo%2C+Julian%3BChang%2C+Yun+C%3BZarember%2C+Kol+A%3BNardone%2C+Glenn%3BGalvez%2C+Eva+M%3BMuellbacher%2C+Arno%3BGallin%2C+John+I%3BSimon%2C+Markus+M%3BKwon-Chung%2C+Kyung+J&rft.aulast=Sugui&rft.aufirst=Janyce&rft.date=2007-09-01&rft.volume=6&rft.issue=9&rft.spage=1562&rft.isbn=&rft.btitle=&rft.title=Eukaryotic+Cell&rft.issn=15359778&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Apoptosis; Hydrocortisone; virulence factors; Leukocytes (neutrophilic); Animal models; Mitochondria; Cell culture; peptide synthase; Neutropenia; Mycotoxins; phosphatidylserine; Superoxide; Caspase-3; gliotoxin; BAK protein; Translocation; thymoma; Immunosuppression; Aspergillus fumigatus ER - TY - JOUR T1 - Design Characteristics of Worksite Environmental Interventions for Obesity Prevention AN - 20313911; 7616354 AB - OBJECTIVE: This paper describes the design characteristics of the National Heart, Lung, and Blood Institute (NHLBI)-funded studies that are testing innovative environmental interventions for weight control and obesity prevention at worksites. RESEARCH METHODS AND PROCEDURES: Seven separate studies that have a total of 114 worksites ( similar to 48,000 employees) across studies are being conducted. The worksite settings include hotels, hospitals, manufacturing facilities, businesses, schools, and bus garages located across the U.S. Each study uses its own conceptual model drawn from the literature and includes the socio-ecological model for health promotion, the epidemiological triad, and those integrating organizational and social contexts. The interventions, which are offered to all employees, include environmental- and individual-level approaches to improve physical activity and promote healthful eating practices. Environmental strategies include reducing portion sizes, modifying cafeteria recipes to lower their fat contents, and increasing the accessibility of fitness equipment at the workplace. Across all seven studies about 48% (N = 23,000) of the population is randomly selected for measurements. The primary outcome measure is change in BMI or body weight after two years of intervention. Secondary measures include waist circumference, objective, and self-report measures of physical activity, dietary intake, changes in vending machines and cafeteria food offerings, work productivity, healthcare use, and return on investment. DISCUSSION: The results of these studies could have important implications for the design and implementation of worksite overweight and obesity control programs. JF - Obesity Research AU - Pratt, Charlotte A AU - Lemon, Stephenie C AU - Fernandez, Isabel Diana AU - Goetzel, Ron AU - Beresford, Shirley A AU - French, Simone A AU - Stevens, Victor J AU - Vogt, Thomas M AU - Webber, Larry S AD - National Heart, Lung, and Blood Institute, Division of Epidemiology and Clinical Applications, Bethesda, Maryland. University of Massachusetts Medical School, Division of Preventive and Behavioral Medicine, Worcester, Massachusetts. Department of Community and Preventive Medicine, University of Rochester School of Medicine, Rochester, New York. Institute for Health and Productivity Studies, Cornell University, Washington, District of Columbia. Fred Hutchinson Cancer Research Center, Seattle, Washington, and University of Washington, Cancer Prevention Program, Seattle, Washington. University of Minnesota, School of Public Health, Minneapolis, Minnesota. Kaiser Permanente Center for Health Research, Portland, Oregon. Kaiser Foundation Hospitals, Center for Health Research, Honolulu, Hawaii. Tulane University School of Public Health, New Orleans, Louisiana Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 2171 EP - 2180 PB - North American Association for the Study of Obesity, 1090 Amsterdam Ave., Ste. 14K New York NY 10025 USA, [mailto:helener@mindspring.com], [URL:http://www.naaso.org] VL - 15 IS - 9 SN - 1071-7323, 1071-7323 KW - Physical Education Index KW - Fitness KW - Measurement KW - Programs KW - Research (statistical design) KW - Eating disorders KW - Promotion KW - Work KW - Worksite KW - Accessibility KW - Heart KW - Obesity KW - Weight control KW - Equipment KW - Business KW - Preventive health KW - Facilities KW - Strategy KW - Employees KW - Diet (weight control) KW - Exercise KW - Blood KW - Schools KW - Waist KW - Hotels KW - Lungs KW - Hospitals KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20313911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obesity+Research&rft.atitle=Design+Characteristics+of+Worksite+Environmental+Interventions+for+Obesity+Prevention&rft.au=Pratt%2C+Charlotte+A%3BLemon%2C+Stephenie+C%3BFernandez%2C+Isabel+Diana%3BGoetzel%2C+Ron%3BBeresford%2C+Shirley+A%3BFrench%2C+Simone+A%3BStevens%2C+Victor+J%3BVogt%2C+Thomas+M%3BWebber%2C+Larry+S&rft.aulast=Pratt&rft.aufirst=Charlotte&rft.date=2007-09-01&rft.volume=15&rft.issue=9&rft.spage=2171&rft.isbn=&rft.btitle=&rft.title=Obesity+Research&rft.issn=10717323&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Fitness; Measurement; Programs; Research (statistical design); Eating disorders; Promotion; Work; Worksite; Accessibility; Heart; Obesity; Equipment; Weight control; Business; Preventive health; Facilities; Strategy; Diet (weight control); Employees; Exercise; Blood; Schools; Waist; Hotels; Lungs; Hospitals ER - TY - JOUR T1 - Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tract AN - 20312447; 7637156 AB - The developing fetus is uniquely sensitive to perturbation by chemicals with hormone-like activity. The adverse effects of prenatal diethylstilbestrol (DES) exposure are a classic example. Since concern has been mounting regarding the human health and environmental effects of bisphenol A (BPA), a high-production-volume chemical with estrogenic activity used in the synthesis of plastics, we investigated its long-term effects in an experimental animal model that was previously shown useful in studying the adverse effects of developmental exposure to DES. Outbred female CD-1 mice were treated on days 1-5 with subcutaneous injections of BPA (10, 100 or 1000 mu g/kg/day) dissolved in corn oil or corn oil alone (Control). At 18 months, ovaries and reproductive tract tissues were examined. There was a statistically significant increase in cystic ovaries and cystic endometrial hyperplasia (CEH) in the BPA-100 group as compared to Controls. Progressive proliferative lesion (PPL) of the oviduct and cystic mesonephric (Wolffian) duct remnants were also seen in all of the BPA groups. More severe pathologies of the uterus following neonatal BPA treatment included adenomyosis, leiomyomas, atypical hyperplasia, and stromal polyps. These data suggest that BPA causes long-term adverse effects if exposure occurs during critical periods of differentiation. JF - Reproductive Toxicology AU - Newbold, R R AU - Jefferson, W N AU - Padilla-Banks, E AD - Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, United States, newbold1@niehs.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 253 EP - 258 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 24 IS - 2 SN - 0890-6238, 0890-6238 KW - Toxicology Abstracts KW - Uterus KW - Endometrium KW - Prenatal experience KW - Statistical analysis KW - Animal models KW - Polyps KW - estrogenic activity KW - Fetuses KW - Oil KW - Bisphenol A KW - Long-term effects KW - Differentiation KW - Hyperplasia KW - Oviduct KW - Environmental effects KW - Neonates KW - Ovaries KW - Plastics KW - Critical period KW - Diethylstilbestrol KW - Side effects KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20312447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+Toxicology&rft.atitle=Long-term+adverse+effects+of+neonatal+exposure+to+bisphenol+A+on+the+murine+female+reproductive+tract&rft.au=Newbold%2C+R+R%3BJefferson%2C+W+N%3BPadilla-Banks%2C+E&rft.aulast=Newbold&rft.aufirst=R&rft.date=2007-09-01&rft.volume=24&rft.issue=2&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Reproductive+Toxicology&rft.issn=08906238&rft_id=info:doi/10.1016%2Fj.reprotox.2007.07.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Endometrium; Uterus; Prenatal experience; Animal models; Statistical analysis; Polyps; estrogenic activity; Fetuses; Long-term effects; Bisphenol A; Oil; Differentiation; Hyperplasia; Oviduct; Environmental effects; Plastics; Ovaries; Neonates; Diethylstilbestrol; Critical period; Side effects DO - http://dx.doi.org/10.1016/j.reprotox.2007.07.006 ER - TY - JOUR T1 - Maternal Serum Polychlorinated Biphenyl Concentrations across Critical Windows of Human Development AN - 20306226; 7594289 AB - BACKGROUND: Few data are available on polychlorinated biphenyl (PCB) concentrations over critical windows of human reproduction and development inclusive of the periconception window. OBJECTIVES: Our goal was to measure changes in PCB concentrations from preconception to pregnancy, through pregnancy, or after a year without becoming pregnant. METHODS: Seventy-nine women planning pregnancies were prospectively enrolled and followed for up to 12 menstrual cycles of attempting pregnancy. Blood specimens were obtained from participating women preconceptionally (n = 79), after a positive pregnancy test leading to a live birth (n = 54) or pregnancy loss (n = 10), at approximately 6 weeks postpartum (n = 53), and after 12 unsuccessful cycles (n = 9) for toxicologic analysis of 76 PCB congeners. We estimated overall and daily rate of change in PCB concentration (nanograms per gram serum) adjusting for relevant covariates, serum lipids, and baseline PCB concentration. RESULTS: Significant (p < 0.0001) decreases in the mean overall and daily rate of change in PCB concentrations were observed between the preconception and first pregnancy samples for total (-1.012 and -0.034, respectively), estrogenic (-0.444 and -0.016, respectively), and antiestrogenic (-0.106 and -0.004, respectively) PCBs among women with live births. Similar significant decreases in total (-1.452 and -0.085), estrogenic (-0.647 and -0.040), and antiestrogenic (-0.093 and -0.004) PCB concentrations were seen for women with pregnancy losses. No significant changes were observed for PCB congener 153. CONCLUSIONS: These data suggest that PCB concentrations may change during the periconception interval, questioning the stability of persistent compounds during this critical window. JF - Environmental Health Perspectives AU - Bloom AU - Louis, GMB AU - Schisterman, E F AU - Liu, A AU - Kostyniak, P J AD - 6100 Executive Blvd., Rm. 7B03, Rockville, MD 20852 USA, louisg@mail.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 1320 EP - 1324 VL - 115 IS - 9 SN - 0091-6765, 0091-6765 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - Lipids KW - Environmental health KW - Reproduction KW - PCB compounds KW - Pregnancy KW - estrogens KW - H 12000:Epidemiology and Public Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20306226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Maternal+Serum+Polychlorinated+Biphenyl+Concentrations+across+Critical+Windows+of+Human+Development&rft.au=Bloom%3BLouis%2C+GMB%3BSchisterman%2C+E+F%3BLiu%2C+A%3BKostyniak%2C+P+J&rft.aulast=Bloom&rft.aufirst=&rft.date=2007-09-01&rft.volume=115&rft.issue=9&rft.spage=1320&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.10086 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Lipids; Environmental health; Reproduction; PCB compounds; estrogens; Pregnancy DO - http://dx.doi.org/10.1289/ehp.10086 ER - TY - JOUR T1 - Meat intake, preparation methods, mutagens and colorectal adenoma recurrence AN - 20304233; 7610235 AB - Red meat intake has been shown to be associated with higher risk of colorectal cancer. Though the exact mechanisms responsible for this association remain unknown, several tumorigenic properties of meat have been proposed. One well-supported biologic mechanism is elevated exposure to the genotoxic formation of heterocyclic amines (HCAs), which occur when meat is cooked at high temperatures for a long period of time. We prospectively assessed the relation between type of meat, meat preparation method, doneness, a metric of HCAs and other mutagens and colorectal adenoma recurrence among 869 participants in a chemoprevention trial of ursodeoxycholic acid. Unconditional logistic regression analyses were used to estimate odds ratios (ORs) and associated 95% confidence intervals (CIs). Most meat variables assessed were positively but weakly associated with recurrence of any adenoma. In contrast, recurrence of advanced or multiple adenomas was more strongly associated with a number of the meat exposure variables evaluated. For recurrence of advanced lesions, significant associations were detected among individuals in the highest when compared with the lowest tertile of intake for pan-fried red meat (OR = 1.85; 95% CI = 1.10-3.13) and well/very well done red meat (OR = 1.71; 95% CI = 1.02-2.86). Significant positive associations were shown for recurrence of multiple adenomas and the following variables: processed meat (OR = 1.83; 95% CI = 1.10-3.04), pan-fried red meat (OR = 1.63; 95% CI = 1.01-2.61), well/very well done red meat (OR = 1.68; 95% CI = 1.03-2.74), 2-amino-3,4,8-trimethylimidazo[4,5,-f]quinoxaline (OR = 1.74; 95% CI = 1.07-2.82) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (OR = 1.68; 95% CI = 1.03-2.75). Our results support a meat mutagen exposure hypothesis as a potential mechanism for recurrence of clinically significant adenomatous polyps. JF - Carcinogenesis AU - Martinez, Maria Elena AU - Jacobs, Elizabeth T AU - Ashbeck, Erin L AU - Sinha, Rashmi AU - Lance, Peter AU - Alberts, David S AU - Thompson, Patricia A AD - Arizona Cancer Center. Mel and Enid Zuckerman Arizona College of Public Health. Department of Nutritional Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, AZ, USA. Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20852, USA. Department of Medicine. Department of Pathology, University of Arizona, Tucson, AZ 85724, USA Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 2019 EP - 2027 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 28 IS - 9 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts KW - Temperature effects KW - Mutagens KW - Heterocyclic amines KW - Genotoxicity KW - Colorectal cancer KW - Polyps KW - Meat KW - Risk factors KW - Carcinogenesis KW - Regression analysis KW - ursodeoxycholic acid KW - Adenoma KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20304233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Meat+intake%2C+preparation+methods%2C+mutagens+and+colorectal+adenoma+recurrence&rft.au=Martinez%2C+Maria+Elena%3BJacobs%2C+Elizabeth+T%3BAshbeck%2C+Erin+L%3BSinha%2C+Rashmi%3BLance%2C+Peter%3BAlberts%2C+David+S%3BThompson%2C+Patricia+A&rft.aulast=Martinez&rft.aufirst=Maria&rft.date=2007-09-01&rft.volume=28&rft.issue=9&rft.spage=2019&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Temperature effects; Meat; Heterocyclic amines; Mutagens; Risk factors; Genotoxicity; Carcinogenesis; Regression analysis; Colorectal cancer; Polyps; ursodeoxycholic acid; Adenoma ER - TY - JOUR T1 - Coxiella burnetii Inhibits Apoptosis in Human THP-1 Cells and Monkey Primary Alveolar Macrophages AN - 20299310; 7557075 AB - Coxiella burnetii, the cause of human Q fever, is an aerosol-borne, obligate intracellular bacterium that targets host alveolar mononuclear phagocytic cells during infection. In all cell types examined, C. burnetii establishes a replicative niche in a lysosome-like parasitophorous vacuole where it carries out a lengthy infectious cycle with minimal cytopathic effects. The persistent and mild nature of C. burnetii infection in vitro suggests that the pathogen modulates apoptosis to sustain the host cell. In the current study, we examined the ability of C. burnetii to inhibit apoptotic cell death during infection of human THP-1 monocyte-derived macrophages and primary monkey alveolar macrophages. C. burnetii-infected cells demonstrated significant protection from death relative to uninfected cells following treatment with staurosporine, a potent inducer of intrinsic apoptosis. This protection correlated with reduced cleavage of caspase-9, caspase-3, and poly(ADP-ribose) polymerase (PARP), all proteolytic events that occur during apoptosis. Reduced PARP cleavage was also observed in cells treated with tumor necrosis factor alpha to induce extrinsic apoptosis. Apoptosis inhibition was a C. burnetii-driven process as infected cells treated with rifampin or chloramphenicol, inhibitors of bacterial RNA and protein synthesis, respectively, showed significantly reduced protection against staurosporine-induced apoptosis. C. burnetii infection affected the expression of multiple apoptosis-related genes and resulted in increased synthesis of the antiapoptotic proteins A1/Bfl-1 and c-IAP2. Collectively, these data suggest that C. burnetii modulates apoptotic pathways to inhibit host cell death, thus providing a stable, intracellular niche for the course of the pathogen's infectious cycle. JF - Infection and Immunity AU - Voth, Daniel E AU - Howe, Dale AU - Heinzen, Robert A AD - Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840 Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 4263 EP - 4271 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 9 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Proteolysis KW - Macrophages KW - Caspase-9 KW - Chloramphenicol KW - Protein biosynthesis KW - Apoptosis KW - Transcription KW - Pathogens KW - Infection KW - Alveoli KW - double prime Q fever KW - parasitophorous vacuole KW - Coxiella burnetii KW - Rifampin KW - RNA KW - Poly(ADP-ribose) polymerase KW - Staurosporine KW - Caspase-3 KW - Tumor necrosis factor- alpha KW - Monocytes KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20299310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Coxiella+burnetii+Inhibits+Apoptosis+in+Human+THP-1+Cells+and+Monkey+Primary+Alveolar+Macrophages&rft.au=Voth%2C+Daniel+E%3BHowe%2C+Dale%3BHeinzen%2C+Robert+A&rft.aulast=Voth&rft.aufirst=Daniel&rft.date=2007-09-01&rft.volume=75&rft.issue=9&rft.spage=4263&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Macrophages; Proteolysis; Caspase-9; Chloramphenicol; Apoptosis; Protein biosynthesis; Transcription; Pathogens; Infection; double prime Q fever; Alveoli; parasitophorous vacuole; Rifampin; RNA; Poly(ADP-ribose) polymerase; Staurosporine; Caspase-3; Monocytes; Tumor necrosis factor- alpha; Coxiella burnetii ER - TY - JOUR T1 - Dectin-1 Interaction with Mycobacterium tuberculosis Leads to Enhanced IL-12p40 Production by Splenic Dendritic Cells AN - 20244222; 7614843 AB - Dectin-1 is a fungal pattern recognition receptor that binds to beta -glucans and triggers cytokine production by facilitating interaction with TLR2 or by directly activating spleen tyrosine kinase (Syk). To assess the possible role of Dectin-1 in the innate response to mycobacteria, we used an in vitro system in which IL-12p40 production is measured in splenic dendritic cells (SpDC) following exposure to live Mycobacterium tuberculosis bacilli. Treatment of SpDC with laminarin or glucan phosphate, two molecules known to block Dectin-1-dependent activity, led to a reduction in M. tuberculosis-induced IL-12p40 as well as IL-12p70 production. Moreover, SpDC from Dectin-1 super(-/-) chimeric mice displayed reduced IL-12p40 production in response to mycobacteria when compared with Dectin-sufficient DC. Laminarin treatment also inhibited mycobacterial-induced IL-12p40 production in DC from TLR2 super(-/-) mice, arguing that Dectin-1 functions independently of TLR2 signaling in this system. Importantly, a Dectin-1 fusion protein was found to directly bind to live mycobacteria in a laminarin-inhibitable manner indicating the presence of ligands for the receptor in the bacterium and laminarin pretreatment resulted in reduced association of mycobacteria to SpDC. In additional experiments, mycobacterial stimulation was shown to be associated with increased phosphorylation of Syk and this response was inhibited by laminarin. Furthermore, pharmacologic inhibition of Syk reduced the M. tuberculosis-induced IL-12p40 response. Together, these findings support a role for Dectin-1 in promoting M. tuberculosis-induced IL-12p40 production by DC in which the receptor augments bacterial-host cell interaction and enhances the subsequent cytokine response through an unknown mechanism involving Syk signaling. JF - Journal of Immunology AU - Rothfuchs, Antonio Gigliotti AU - Bafica, Andre AU - Feng, Carl G AU - Egen, Jackson G AU - Williams, David L AU - Brown, Gordon D AU - Sher, Alan AD - Immunobiology Section, Laboratory of Parasitic Diseases and Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892. Division of Immunology, Department of Microbiology and Parasitology, Federal University of Santa Catarina, Florianopolis, Brazil. Department of Surgery, James H. Quillen College of Medicine, Johnson City, TN 37614. Division of Immunology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch, South Africa Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 3463 EP - 3471 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 179 IS - 6 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Bacilli KW - TLR2 protein KW - Spleen KW - Syk protein KW - beta -Glucan KW - Pattern recognition KW - Dendritic cells KW - Interleukin 12 KW - Phosphorylation KW - Phosphate KW - Protein-tyrosine kinase KW - Fusion protein KW - Cell interactions KW - Toll-like receptors KW - laminarin KW - glucans KW - Mycobacterium tuberculosis KW - Signal transduction KW - K 03350:Immunology KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20244222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Dectin-1+Interaction+with+Mycobacterium+tuberculosis+Leads+to+Enhanced+IL-12p40+Production+by+Splenic+Dendritic+Cells&rft.au=Rothfuchs%2C+Antonio+Gigliotti%3BBafica%2C+Andre%3BFeng%2C+Carl+G%3BEgen%2C+Jackson+G%3BWilliams%2C+David+L%3BBrown%2C+Gordon+D%3BSher%2C+Alan&rft.aulast=Rothfuchs&rft.aufirst=Antonio&rft.date=2007-09-01&rft.volume=179&rft.issue=6&rft.spage=3463&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Bacilli; TLR2 protein; Spleen; Syk protein; beta -Glucan; Interleukin 12; Dendritic cells; Pattern recognition; Phosphate; Phosphorylation; Protein-tyrosine kinase; Cell interactions; Fusion protein; glucans; laminarin; Toll-like receptors; Signal transduction; Mycobacterium tuberculosis ER - TY - JOUR T1 - Neurotoxicity of substituted amphetamines: Molecular and cellular mechanisms AN - 20151458; 10263304 AB - The amphetamines, including amphetamine (AMPH), methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA), are among abused drugs in the US and throughout the world. Their abuse is associated with severe neurologic and psychiatric adverse events including the development of psychotic states. These neuropsychiatric complications might, in part, be related to drug-induced neurotoxic effects, which include damage to dopaminergic and serotonergic terminals, neuronal apoptosis, as well as activated astroglial and microglial cells in the brain. The purpose of the present review is to summarize the toxic effects of AMPH, METH and MDMA. The paper also presents some of the factors that are thought to underlie this toxicity. These include oxidative stress, hyperthermia, excitotoxicity and various apoptotic pathways. Better understanding of the cellular and molecular mechanisms involved in their toxicity should help to generate modern therapeutic approaches to prevent or attenuate the long-term consequences of amphetamine use disorders in humans. JF - Neurotoxicity Research AU - Cadet, Jean Lud AU - Krasnova, Irina N AU - Jayanthi, Subramaniam AU - Lyles, Johnalyn AD - Molecular Neuropsychiatry Branch, DHHS/NIH/NIDA, Intramural Research Program, 5500 Nathan Shock Drive, 21224 Baltimore, Maryland, USA, jcadet@intra.nida.nih.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 183 EP - 202 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 11 IS - 3-4 SN - 1029-8428, 1029-8428 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Molecular modelling KW - Hyperthermia KW - Apoptosis KW - Brain KW - Drug abuse KW - MDMA KW - Serotonin KW - Methamphetamine KW - Dopamine KW - Oxidative stress KW - Reviews KW - Neurotoxicity KW - Amphetamine KW - Microglial cells KW - Excitotoxicity KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20151458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicity+Research&rft.atitle=Neurotoxicity+of+substituted+amphetamines%3A+Molecular+and+cellular+mechanisms&rft.au=Cadet%2C+Jean+Lud%3BKrasnova%2C+Irina+N%3BJayanthi%2C+Subramaniam%3BLyles%2C+Johnalyn&rft.aulast=Cadet&rft.aufirst=Jean&rft.date=2007-09-01&rft.volume=11&rft.issue=3-4&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Neurotoxicity+Research&rft.issn=10298428&rft_id=info:doi/10.1007%2FBF03033567 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Hyperthermia; Apoptosis; Brain; Drug abuse; MDMA; Serotonin; Methamphetamine; Dopamine; Oxidative stress; Reviews; Neurotoxicity; Amphetamine; Microglial cells; Excitotoxicity DO - http://dx.doi.org/10.1007/BF03033567 ER - TY - JOUR T1 - Performance characteristics of 65-mer oligonucleotide microarrays AN - 20091423; 7537068 AB - Microarray fabrication using presynthesized long oligonucleotide is becoming increasingly important, but a study of large-scale array productions has not yet been published. We addressed the issue of fabricating oligonucleotide microarrays by spotting commercial presynthesized 65-mers with 5' amines representing 7500 murine genes. Amine-modified oligonucleotides were immobilized on glass slides having aldehyde groups via transient Schiff base formation followed by reduction to produce a covalent conjugate. When RNA derived from the same source was used for Cy3 and Cy5 labeling and hybridized to the same array, signal intensities spanning three orders of magnitude were observed and the coefficient of variance (CV) between the two channels for all spots was 8 to 10%. To ascertain the reproducibility of ratio determination of these arrays, two triplicate hybridizations (with fluorochrome reversal) comparing RNAs from a fibroblast (NIH3T3) and a breast cancer (JC) cell line were carried out. The 95% confidence interval for all spots in the six hybridizations was 0.60 to 1.66. This level of reproducibility allows use of the full range of pattern finding and discriminant analysis typically applied to complementary DNA (cDNA) microarrays. Further comparative testing was carried out with oligonucleotide microarrays, cDNA microarrays, and reverse transcription (RT)-PCR assays to examine the comparability of results across these different methodologies. JF - Analytical Biochemistry AU - Lee, Myoyong AU - Xiang, Charlie C AU - Trent, Jeffrey M AU - Bittner, Michael L AD - Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA, myoyong.lee@samsung.com Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 70 EP - 78 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 368 IS - 1 SN - 0003-2697, 0003-2697 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Oligonucleotide KW - Microarray KW - Gene expression KW - Tumor cell lines KW - amines KW - RNA KW - Breast cancer KW - fluorochromes KW - Aldehydes KW - DNA microarrays KW - Oligonucleotides KW - Fibroblasts KW - Reverse transcription KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20091423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Biochemistry&rft.atitle=Performance+characteristics+of+65-mer+oligonucleotide+microarrays&rft.au=Lee%2C+Myoyong%3BXiang%2C+Charlie+C%3BTrent%2C+Jeffrey+M%3BBittner%2C+Michael+L&rft.aulast=Lee&rft.aufirst=Myoyong&rft.date=2007-09-01&rft.volume=368&rft.issue=1&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=Analytical+Biochemistry&rft.issn=00032697&rft_id=info:doi/10.1016%2Fj.ab.2007.05.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - amines; Tumor cell lines; RNA; Breast cancer; fluorochromes; Aldehydes; Oligonucleotides; DNA microarrays; Reverse transcription; Fibroblasts DO - http://dx.doi.org/10.1016/j.ab.2007.05.010 ER - TY - JOUR T1 - Optimization of oligonucleotide microarray fabricated by spotting 65-mer AN - 20091254; 7537067 AB - DNA microarrays currently provide measurements of sufficiently high quality to allow a wide variety of sound inferences about gene regulation and the coordination of cellular processes to be drawn. Nonetheless, a desire for greater precision in the measurements continues to drive the microarray research community to seek higher measurement quality through improvements in array fabrication and sample labeling and hybridization. We prepared oligonucleotide microarrays by printing 65-mer on aldehyde functional group-derivatized slides as described in a previous study. We could improve the reliability of data by removing enzymatic bias during probe labeling and hybridizing under a more stringent condition. This optimized method was used to profile gene expression patterns for nine different mouse tissues and organs, and multidimensional scaling (MDS) analysis of data showed both strong similarity between like samples and a clear, highly reproducible separation between different tissue samples. Three other microarrays were fabricated on commercial substrates and hybridized following the manufacturer's instructions. The data were then compared with in-house microarray data and reverse transcription-polymerase chain reaction (RT-PCR) data. The microarray printed on the custom aldehyde slide was superior to microarrays printed on commercially available substrate slides in terms of signal intensities, background, and hybridization characteristics. The data from the custom substrate microarray generally showed good agreement in quantitative changes up to 100-fold changes of transcript abundance with RT-PCR data. However, more accurate comparisons will be made as more genomic sequence information is gathered in the public data domain. JF - Analytical Biochemistry AU - Lee, Myoyong AU - Trent, Jeffrey M AU - Bittner, Michael L AD - Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA, myoyong.lee@samsung.com Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 61 EP - 69 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 368 IS - 1 SN - 0003-2697, 0003-2697 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Oligonucleotide KW - Microarray KW - Spotting KW - Gene expression KW - Printing KW - Data processing KW - DNA probes KW - Abundance KW - Transcription KW - Oligonucleotides KW - DNA microarrays KW - Gene regulation KW - Multidimensional scaling KW - Sound KW - Polymerase chain reaction KW - genomics KW - Aldehydes KW - W 30910:Imaging KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20091254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+biological+therapy&rft.atitle=First-generation+blood+substitutes%3A+what+have+we+learned%3F+Biochemical+and+physiological+perspectives.&rft.au=Alayash%2C+Abdu+I%3BD%27Agnillo%2C+Felice%3BBuehler%2C+Paul+W&rft.aulast=Alayash&rft.aufirst=Abdu&rft.date=2007-05-01&rft.volume=7&rft.issue=5&rft.spage=665&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+biological+therapy&rft.issn=1744-7682&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Data processing; Printing; DNA probes; Abundance; Transcription; DNA microarrays; Oligonucleotides; Gene expression; Gene regulation; Multidimensional scaling; Sound; Polymerase chain reaction; genomics; Aldehydes DO - http://dx.doi.org/10.1016/j.ab.2007.06.005 ER - TY - JOUR T1 - AffyProbeMiner: a web resource for computing or retrieving accurately redefined Affymetrix probe sets AN - 20025689; 7609368 AB - MOTIVATION: Affymetrix microarrays are widely used to measure global expression of mRNA transcripts. That technology is based on the concept of a probe set. Individual probes within a probe set were originally designated by Affymetrix to hybridize with the same unique mRNA transcript. Because of increasing accuracy in knowledge of genomic sequences, however, a substantial number of the manufacturer's original probe groupings and mappings are now known to be inaccurate and must be corrected. Otherwise, analysis and interpretation of an Affymetrix microarray experiment will be in error. RESULTS: AffyProbeMiner is a computationally efficient platform-independent tool that uses all RefSeq mature RNA protein coding transcripts and validated complete coding sequences in GenBank to (1) regroup the individual probes into consistent probe sets and (2) remap the probe sets to the correct sets of mRNA transcripts. The individual probes are grouped into probe sets that are 'transcript-consistent' in that they hybridize to the same mRNA transcript (or transcripts) and, therefore, measure the same entity (or entities). About 65.6 % of the probe sets on the HG-U133A chip were affected by the remapping. Pre-computed regrouped and remapped probe sets for many Affymetrix microarrays are made freely available at the AffyProbeMiner web site. Alternatively, we provide a web service that enables the user to perform the remapping for any type of short-oligo commercial or custom array that has an Affymetrix-format Chip Definition File (CDF). Important features that differentiate AffyProbeMiner from other approaches are flexibility in the handling of splice variants, computational efficiency, extensibility, customizability and user-friendliness of the interface. AVAILABILITY: The web interface and software (GPL open source license), are publicly-accessible at http://discover.nci.nih.gov/affyprobeminer. CONTACT: hl224atgeorgetown.edu or barryatdiscover.nci.nih.gov JF - Bioinformatics AU - Liu, Hongfang AU - Zeeberg, Barry R AU - Qu, Gang AU - Koru, AGunes AU - Ferrucci, Alessandro AU - Kahn, Ari AU - Ryan, Michael C AU - Nuhanovic, Antej AU - Munson, Peter J AU - Reinhold, William C AU - Kane, David W AU - Weinstein, John N AD - Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, Department of Biostatistics, Bioinformatics, and Biomathematics, Georgetown University Medical Center, 4000 Reservoir Road, NW, Washington, DC 20007, Electrical & Computer Engineering and Institute for Advanced Studies, University of Maryland, College Park, College Park, MD 20742, Department of Information Systems, Department of Computer Science and Electrical Engineering, University of Maryland, Baltimore County, 1000 Hilltop Circle, MD 21050, Department of Bioinformatics, George Mason University, Fairfax, Virginia, 20110, Mathematical and Statistical Computing Laboratory, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, MD 20892 and SRA International, 4300 Fair Lakes Court, Fairfax, VA 22033, USA Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 2385 EP - 2390 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 23 IS - 18 SN - 1367-4803, 1367-4803 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Computer programs KW - software KW - DNA probes KW - Bioinformatics KW - genomics KW - Computer applications KW - Internet KW - Alternative splicing KW - Gene mapping KW - N 14815:Nucleotide Sequence KW - W 30960:Bioinformatics & Computer Applications KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20025689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=AffyProbeMiner%3A+a+web+resource+for+computing+or+retrieving+accurately+redefined+Affymetrix+probe+sets&rft.au=Liu%2C+Hongfang%3BZeeberg%2C+Barry+R%3BQu%2C+Gang%3BKoru%2C+AGunes%3BFerrucci%2C+Alessandro%3BKahn%2C+Ari%3BRyan%2C+Michael+C%3BNuhanovic%2C+Antej%3BMunson%2C+Peter+J%3BReinhold%2C+William+C%3BKane%2C+David+W%3BWeinstein%2C+John+N&rft.aulast=Liu&rft.aufirst=Hongfang&rft.date=2007-09-01&rft.volume=23&rft.issue=18&rft.spage=2385&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gene expression; Computer programs; software; DNA probes; genomics; Bioinformatics; Computer applications; Internet; Gene mapping; Alternative splicing ER - TY - JOUR T1 - RSV604, a Novel Inhibitor of Respiratory Syncytial Virus Replication AN - 20004075; 7554009 AB - Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infections worldwide, yet no effective vaccine or antiviral treatment is available. Here we report the discovery and initial development of RSV604, a novel benzodiazepine with submicromolar anti-RSV activity. It proved to be equipotent against all clinical isolates tested of both the A and B subtypes of the virus. The compound has a low rate of in vitro resistance development. Sequencing revealed that the resistant virus had mutations within the nucleocapsid protein. This is a novel mechanism of action for anti-RSV compounds. In a three-dimensional human airway epithelial cell model, RSV604 was able to pass from the basolateral side of the epithelium effectively to inhibit virus replication after mucosal inoculation. RSV604, which is currently in phase II clinical trials, represents the first in a new class of RSV inhibitors and may have significant potential for the effective treatment of RSV disease. JF - Antimicrobial Agents & Chemotherapy AU - Chapman, Joanna AU - Abbott, Elizabeth AU - Alber, Dagmar G AU - Baxter, Robert C AU - Bithell, Sian K AU - Henderson, Elisa A AU - Carter, Malcolm C AU - Chambers, Phil AU - Chubb, Ann AU - Cockerill, GStuart AU - Collins, Peter L AU - Dowdell, Verity CL AU - Keegan, Sally J AU - Kelsey, Richard D AU - Lockyer, Michael J AU - Luongo, Cindy AU - Najarro, Pilar AU - Pickles, Raymond J AU - Simmonds, Mark AU - Taylor, Debbie AU - Tyms, Stan AU - Wilson, Lara J AU - Powell, Kenneth L AD - Arrow Therapeutics Ltd., Britannia House, 7 Trinity Street, London SE1 1DB, United Kingdom. Virogen Ltd., MRC Technology, 1-3 Burtonhole Lane, Mill Hill, London NW7 1AD, United Kingdom. Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, 7 Center Drive, MSC 0720, Bethesda, Maryland. Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 3346 EP - 3353 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 51 IS - 9 SN - 0066-4804, 0066-4804 KW - RSV604 KW - anti-RSV activity KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Clinical isolates KW - Epithelial cells KW - Replication KW - Mucosa KW - Cell culture KW - Infection KW - Clinical trials KW - Respiratory syncytial virus KW - Respiratory tract diseases KW - Benzodiazepine KW - Nucleocapsids KW - Inoculation KW - Epithelium KW - Vaccines KW - Mutation KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents KW - V 22320:Replication KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20004075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=RSV604%2C+a+Novel+Inhibitor+of+Respiratory+Syncytial+Virus+Replication&rft.au=Chapman%2C+Joanna%3BAbbott%2C+Elizabeth%3BAlber%2C+Dagmar+G%3BBaxter%2C+Robert+C%3BBithell%2C+Sian+K%3BHenderson%2C+Elisa+A%3BCarter%2C+Malcolm+C%3BChambers%2C+Phil%3BChubb%2C+Ann%3BCockerill%2C+GStuart%3BCollins%2C+Peter+L%3BDowdell%2C+Verity+CL%3BKeegan%2C+Sally+J%3BKelsey%2C+Richard+D%3BLockyer%2C+Michael+J%3BLuongo%2C+Cindy%3BNajarro%2C+Pilar%3BPickles%2C+Raymond+J%3BSimmonds%2C+Mark%3BTaylor%2C+Debbie%3BTyms%2C+Stan%3BWilson%2C+Lara+J%3BPowell%2C+Kenneth+L&rft.aulast=Chapman&rft.aufirst=Joanna&rft.date=2007-09-01&rft.volume=51&rft.issue=9&rft.spage=3346&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Epithelial cells; Replication; Mucosa; Cell culture; Infection; Clinical trials; Respiratory tract diseases; Benzodiazepine; Inoculation; Nucleocapsids; Epithelium; Vaccines; Mutation; Respiratory syncytial virus ER - TY - JOUR T1 - Oxygen Tension Regulates Survival and Fate of Mouse Central Nervous System Precursors at Multiple Levels AN - 20003203; 7617395 AB - Despite evidence that oxygen regulates neural precursor fate, the effects of changing oxygen tensions on distinct stages in precursor differentiation are poorly understood. We found that 5% oxygen permitted clonal and long-term expansion of mouse fetal cortical precursors. In contrast, 20% oxygen caused a rapid decrease in hypoxia-inducible factor 1 alpha and nucleophosmin, followed by the induction of p53 and apoptosis of cells. This led to a decrease in overall cell number and particularly a loss of astrocytes and oligodendrocytes. Clonal analysis revealed that apoptosis in 20% oxygen was due to a complete loss of CD133 super(lo)CD24 super(lo) multipotent precursors, a substantial loss of CD133 super(hi)CD24 super(lo) multipotent precursors, and a failure of remaining CD133 super(hi)CD24 super(lo) cells to generate glia. In contrast, committed neuronal progenitors were not significantly affected. Switching clones from 5% to 20% oxygen only after mitogen withdrawal led to a decrease in total clone numbers but an even greater decrease in oligodendrocyte-containing clones. During this late exposure to 20% oxygen, bipotent glial (A2B5 super(+)) and early (platelet-derived growth factor receptor alpha ) oligodendrocyte progenitors appeared and disappeared more quickly, relative to 5% oxygen, and late stage O4 super(+) oligodendrocyte progenitors never appeared. These results indicate that multipotent cells and oligodendrocyte progenitors are more susceptible to apoptosis at 20% oxygen than committed neuronal progenitors. This has important implications for optimizing ex vivo production methods for cell replacement therapies. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Chen, Hui-Ling AU - Pistollato, Francesca AU - Hoeppner, Daniel J AU - Ni, Hsiao-Tzu AU - McKay, Ronald DG AU - Panchision, David M AD - Center for Neuroscience Research, Children's National Medical Center, Washington, DC, USA. Hemato-Oncology Laboratory, Department of Pediatrics, University of Padua, Padua, Italy. Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA. R&D Systems, Inc., Minneapolis, Minnesota, USA Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 2291 EP - 2301 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 25 IS - 9 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Central nervous system KW - Apoptosis KW - Cell number KW - Oxygen tension KW - Oligodendrocytes KW - Astrocytes KW - Hypoxia-inducible factor 1 alpha KW - Fetuses KW - p53 protein KW - Differentiation KW - Stem cells KW - Glial stem cells KW - Platelet-derived growth factor receptors KW - Glia KW - Mitogens KW - Neural stem cells KW - W 30965:Miscellaneous, Reviews KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20003203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Oxygen+Tension+Regulates+Survival+and+Fate+of+Mouse+Central+Nervous+System+Precursors+at+Multiple+Levels&rft.au=Chen%2C+Hui-Ling%3BPistollato%2C+Francesca%3BHoeppner%2C+Daniel+J%3BNi%2C+Hsiao-Tzu%3BMcKay%2C+Ronald+DG%3BPanchision%2C+David+M&rft.aulast=Chen&rft.aufirst=Hui-Ling&rft.date=2007-09-01&rft.volume=25&rft.issue=9&rft.spage=2291&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Central nervous system; Apoptosis; Astrocytes; Oligodendrocytes; Oxygen tension; Cell number; Hypoxia-inducible factor 1 alpha; Fetuses; p53 protein; Differentiation; Stem cells; Glial stem cells; Platelet-derived growth factor receptors; Glia; Mitogens; Neural stem cells ER - TY - JOUR T1 - Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulation AN - 20003096; 7616844 AB - The mechanisms that regulate hematopoietic stem cell (HSC) fate decisions between proliferation and multilineage differentiation are unclear. Members of the Wnt family of ligands that activate the canonical Wnt signaling pathway, which utilizes beta -catenin to relay the signal, have been demonstrated to regulate HSC function. In this study, we examined the role of noncanonical Wnt signaling in regulating HSC fate. We observed that noncanonical Wnt5a inhibited Wnt3a-mediated canonical Wnt signaling in HSCs and suppressed Wnt3a-mediated alterations in gene expression associated with HSC differentiation, such as increased expression of myc. Wnt5a increased short- and long-term HSC repopulation by maintaining HSCs in a quiescent G sub(0) state. From these data, we propose that Wnt5a regulates hematopoiesis by the antagonism of the canonical Wnt pathway, resulting in a pool of quiescent HSCs. JF - Proceedings of the National Academy of Sciences, USA AU - Nemeth, Michael J AU - Topol, Lilia AU - Anderson, Stacie M AU - Yang, Yingzi AU - Bodine, David M AD - Genetics and Molecular Biology Branch and Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, MD 20892-4442 Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 15436 EP - 15441 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 39 SN - 0027-8424, 0027-8424 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Gene expression KW - Myc protein KW - Differentiation KW - Stem cells KW - Wnt protein KW - catenin KW - Data processing KW - Hemopoiesis KW - Antagonism KW - Signal transduction KW - G 07730:Development & Cell Cycle KW - W 30970:Book & Conference Notices UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20003096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Wnt5a+inhibits+canonical+Wnt+signaling+in+hematopoietic+stem+cells+and+enhances+repopulation&rft.au=Nemeth%2C+Michael+J%3BTopol%2C+Lilia%3BAnderson%2C+Stacie+M%3BYang%2C+Yingzi%3BBodine%2C+David+M&rft.aulast=Nemeth&rft.aufirst=Michael&rft.date=2007-09-01&rft.volume=104&rft.issue=39&rft.spage=15436&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Myc protein; Gene expression; Differentiation; Stem cells; Data processing; catenin; Wnt protein; Hemopoiesis; Antagonism; Signal transduction ER - TY - JOUR T1 - Expression of Interleukin-13 Receptor alpha 2 in Glioblastoma Multiforme: Implications for Targeted Therapies AN - 19876213; 7609987 AB - Glioblastoma multiforme is the most common primary malignant brain tumor and despite treatment with surgery, radiation, and chemotherapy, the median survival of patients with glioblastoma multiforme is similar to 1 year. Glioblastoma multiforme explants and cell lines have been reported to overexpress the interleukin-13 receptor alpha 2 subunit (IL13R alpha 2) relative to nonneoplastic brain. Based on this finding, a recombinant cytotoxin composed of IL13 ligand and a truncated form of Pseudomonas aeruginosa exotoxin A (IL13-PE38QQR) was developed for the targeted treatment of glioblastoma multiforme tumors. In a recently completed phase III clinical trial, however, IL13-PE38QQR was found to be no more effective than an existing therapy in prolonging survival. To determine possible explanations for this result, we analyzed the relative expression levels of IL13R alpha 2 in glioblastoma multiforme and nonneoplastic brain specimens using publicly available oligonucleotide microarray databases, quantitative real-time reverse transcription PCR, and immunohistochemical staining. Increased expression of the IL13R alpha 2 gene relative to nonneoplastic brain was observed in 36 of 81 (44%) and 8 of 17 (47%) tumor specimens by microarray and quantitative real-time reverse transcription PCR analyses, respectively. Immunohistochemical staining of tumor specimens showed highly variable expression of IL13R alpha 2 protein both within and across specimens. These data indicate that prescreening of subjects may be of benefit in future trials of IL13R alpha 2 targeting therapies. [Cancer Res 2007; 67(17):7983-6] JF - Cancer Research AU - Jarboe, John S AU - Johnson, Kory R AU - Choi, Yong AU - Lonser, Russell R AU - Park, John K AD - Surgical and Molecular Neuro-oncology Unit, Bioinformatics Group, Intramural Information Technology Program, Division of Intramural Research, and Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - 7983 EP - 7986 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 67 IS - 17 SN - 0008-5472, 0008-5472 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Data processing KW - glioblastoma multiforme KW - Cytotoxins KW - Chemotherapy KW - Interleukin 1 KW - Survival KW - exotoxin A KW - DNA microarrays KW - Clinical trials KW - Oligonucleotides KW - Cancer KW - Reverse transcription KW - Brain tumors KW - Databases KW - Interleukin 13 KW - Radiation KW - Surgery KW - Polymerase chain reaction KW - Pseudomonas aeruginosa KW - Explants KW - F 06915:Cancer Immunology KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19876213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Genetic+alterations+in+K-ras+and+p53+cancer+genes+in+lung+neoplasms+from+Swiss+%28CD-1%29+male+mice+exposed+transplacentally+to+AZT&rft.au=Hong%2C+Hue-Hua+L%3BDunnick%2C+June%3BHerbert%2C+Ronald%3BDevereux%2C+Theodora+R%3BKim%2C+Yongbaek%3BSills%2C+Robert+C&rft.aulast=Hong&rft.aufirst=Hue-Hua&rft.date=2007-05-01&rft.volume=48&rft.issue=3-4&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20197 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Data processing; glioblastoma multiforme; Chemotherapy; Cytotoxins; Interleukin 1; Survival; Oligonucleotides; Clinical trials; DNA microarrays; exotoxin A; Cancer; Reverse transcription; Brain tumors; Databases; Interleukin 13; Radiation; Surgery; Polymerase chain reaction; Explants; Pseudomonas aeruginosa ER - TY - JOUR T1 - Expression of a CALM-AF10 Fusion Gene Leads to Hoxa Cluster Overexpression and Acute Leukemia in Transgenic Mice AN - 19875660; 7609994 AB - To assess the role of the CALM-AF10 fusion gene in leukemic transformation in vivo, we generated transgenic mice that expressed a CALM-AF10 fusion gene. Depending on the transgenic line, at least 40% to 50% of the F sub(1) generation mice developed acute leukemia at a median age of 12 months. Leukemic mice typically had enlarged spleens, invasion of parenchymal organs with malignant cells, and tumors with myeloid markers such as myeloperoxidase, Mac1, and Gr1. Although most leukemias were acute myeloid leukemia, many showed lymphoid features, such as CD3 staining, or clonal Tcrb or Igh gene rearrangements. Mice were clinically healthy for the first 9 months of life and had normal peripheral blood hemograms but showed impaired thymocyte differentiation, manifested by decreased CD4 super(+)/CD8 super(+) cells and increased immature CD4 super(-)/CD8 super(-) cells in the thymus. Hematopoietic tissues from both clinically healthy and leukemic CALM-AF10 mice showed up-regulation of Hoxa cluster genes, suggesting a potential mechanism for the impaired differentiation. The long latency period and incomplete penetrance suggest that additional genetic events are needed to complement the CALM-AF10 transgene and complete the process of leukemic transformation. [Cancer Res 2007; 67(17):8022-31] JF - Cancer Research AU - Caudell, David AU - Zhang, Zhenhua AU - Chung, Yang Jo AU - Aplan, Peter D AD - Genetics Branch and Comparative Molecular Pathology Unit, National Cancer Institute, National Institutes for Health, Bethesda, Maryland and Department of Veterinary Medical Sciences, University of Maryland, College Park, Maryland Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - 8022 EP - 8031 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 67 IS - 17 SN - 0008-5472, 0008-5472 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Transformation KW - Age KW - Acute myeloid leukemia KW - double prime T-cell receptor KW - Peroxidase KW - Thymus KW - Spleen KW - Peripheral blood KW - Tumors KW - CD8 antigen KW - Transgenic mice KW - Cancer KW - Differentiation KW - CD4 antigen KW - Gene fusion KW - gene rearrangement KW - Hemopoiesis KW - Thymocytes KW - CD3 antigen KW - Fusion protein KW - Immunoglobulins KW - W 30925:Genetic Engineering KW - F 06915:Cancer Immunology KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19875660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Expression+of+a+CALM-AF10+Fusion+Gene+Leads+to+Hoxa+Cluster+Overexpression+and+Acute+Leukemia+in+Transgenic+Mice&rft.au=Caudell%2C+David%3BZhang%2C+Zhenhua%3BChung%2C+Yang+Jo%3BAplan%2C+Peter+D&rft.aulast=Caudell&rft.aufirst=David&rft.date=2007-09-01&rft.volume=67&rft.issue=17&rft.spage=8022&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Transformation; Age; Acute myeloid leukemia; Peroxidase; double prime T-cell receptor; Thymus; Spleen; Peripheral blood; CD8 antigen; Tumors; Transgenic mice; Cancer; Differentiation; CD4 antigen; gene rearrangement; Gene fusion; Hemopoiesis; Thymocytes; Fusion protein; CD3 antigen; Immunoglobulins ER - TY - JOUR T1 - The RAGNYA fold: a novel fold with multiple topological variants found in functionally diverse nucleic acid, nucleotide and peptide-binding proteins AN - 19795544; 7616184 AB - Using sensitive structure similarity searches, we identify a shared alpha +{szligbeta} fold, RAGNYA, principally involved in nucleic acid, nucleotide or peptide interactions in a diverse group of proteins. These include the Ribosomal proteins L3 and L1, ATP-grasp modules, the GYF domain, DNA-recombination proteins of the NinB family from caudate bacteriophages, the C-terminal DNA-interacting domain of the Y-family DNA polymerases, the uncharacterized enzyme AMMECR1, the siRNA silencing repressor of tombusviruses, tRNA Wybutosine biosynthesis enzyme Tyw3p, DNA/RNA ligases and related nucleotidyltransferases and the Enhancer of rudimentary proteins. This fold exhibits three distinct circularly permuted versions and is composed of an internal repeat of a unit with two-strands and a helix. We show that despite considerable structural diversity in the fold, its representatives show a common mode of nucleic acid or nucleotide interaction via the exposed face of the sheet. Using this information and sensitive profile-based sequence searches: (1) we predict the active site, and mode of substrate interaction of the Wybutosine biosynthesis enzyme, Tyw3p, and a potential catalytic role for AMMECR1. (2) We provide insights regarding the mode of nucleic acid interaction of the NinB proteins, and the evolution of the active site of classical ATP-grasp enzymes and DNA/RNA ligases. (3) We also present evidence for a bacterial origin of the GYF domain and propose how this version of the fold might have been utilized in peptide interactions in the context of nucleoprotein complexes. JF - Nucleic Acids Research AU - Balaji, S AU - Aravind, L AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 5658 EP - 5671 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 35 IS - 17 SN - 0305-1048, 0305-1048 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Phages KW - DNA biosynthesis KW - tRNA KW - Nucleotide sequence KW - Nucleoproteins KW - Enzymes KW - Nucleotides KW - Enhancers KW - nucleic acids KW - siRNA KW - DNA-directed DNA polymerase KW - ribosomal protein L3 KW - Repressors KW - peptide-binding protein KW - RNA ligase KW - Evolution KW - J 02320:Cell Biology KW - V 22320:Replication KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19795544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=The+RAGNYA+fold%3A+a+novel+fold+with+multiple+topological+variants+found+in+functionally+diverse+nucleic+acid%2C+nucleotide+and+peptide-binding+proteins&rft.au=Balaji%2C+S%3BAravind%2C+L&rft.aulast=Balaji&rft.aufirst=S&rft.date=2007-09-01&rft.volume=35&rft.issue=17&rft.spage=5658&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Phages; DNA biosynthesis; Nucleotide sequence; tRNA; Nucleoproteins; Enzymes; Nucleotides; Enhancers; nucleic acids; siRNA; DNA-directed DNA polymerase; ribosomal protein L3; Repressors; Evolution; RNA ligase; peptide-binding protein ER - TY - JOUR T1 - Radioimmunotherapy with alpha -Particle-Emitting super(213)Bi-C-Functionalized trans-Cyclohexyl-Diethylenetriaminepentaacetic Acid-Humanized 3S193 Is Enhanced by Combination with Paclitaxel Chemotherapy AN - 19787028; 7612371 AB - PURPOSE: Previous experience in solid tumor radioimmunotherapy studies has indicated that greatest therapeutic efficacy is achieved in the treatment of small-volume disease. alpha -Particle-emitting radioisotopes possess several physical characteristics ideally suited to the treatment of minimal residual disease. Therefore, we have investigated the efficacy of the alpha -particle-emitting bismuth-213 ( super(213)Bi) radioimmunotherapy using the humanized anti-Lewis Y (Le super(y)) monoclonal antibody humanized 3S193 (hu3S193). Experimental Design: The intracellular localization of hu3S193 in Le super(y)-positive MCF-7 breast carcinoma cells was assessed by confocal microscopy. Cytotoxicity of super(213)Bi-hu3S193 and apoptosis was assessed using [ super(3)H]thymidine incorporation assay and ELISA, respectively. Immunoblotting for gamma -H2AX assessed DNA strand breaks. In vivo efficacy of super(213)Bi-hu3S193 was assessed using a minimal residual disease model in BALB/c nude mice, with radioconjugate [15, 30, and 60 mu Ci (9.2 mu g)] injected 2 days after s.c. implantation of MCF-7 cells. Radioimmunotherapy was also combined with a single injection of 300 mu g paclitaxel to explore improved efficacy. Further, mice with established tumors received 30, 60, or 120 mu Ci (14.5 mu g) of super(213)Bi-hu3S193 to assess the effect of tumor volume on treatment efficacy. RESULTS: hu3S193 is internalized via an endosomal and lysosomal trafficking pathway. Treatment with super(213)Bi-hu3S193 results in >90% cytotoxicity in vitro and induces apoptosis and increased gamma -H2AX expression. super(213)Bi-hu3S193 causes specific and significant retardation of tumor growth even in established tumors, and efficacy was enhanced by paclitaxel to produce defined complete responses. CONCLUSIONS: These studies show the potency of alpha -particle radioimmunotherapy and warrant its further exploration in the treatment of micrometastatic disease in Le super(y)-positive malignancies. JF - Clinical Cancer Research AU - Kelly, Marcus P AU - Lee, Fook T AU - Tahtis, Kiki AU - Smyth, Fiona E AU - Brechbiel, Martin W AU - Scott, Andrew M AD - Authors' Affiliations: Tumour Targeting Program, Ludwig Institute for Cancer Research, Austin Hospital, Heidelberg, Victoria, Australia and Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 5604s EP - 5612s PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 13 IS - 18 SN - 1078-0432, 1078-0432 KW - Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Immunoblotting KW - Physical characteristics KW - Enzyme-linked immunosorbent assay KW - Apoptosis KW - Monoclonal antibodies KW - Solid tumors KW - Chemotherapy KW - Animal models KW - Tumors KW - DNA damage KW - Malignancy KW - Cytotoxicity KW - minimal residual disease KW - Paclitaxel KW - Confocal microscopy KW - Radioisotopes KW - Breast carcinoma KW - F 06915:Cancer Immunology KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19787028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Radioimmunotherapy+with+alpha+-Particle-Emitting+super%28213%29Bi-C-Functionalized+trans-Cyclohexyl-Diethylenetriaminepentaacetic+Acid-Humanized+3S193+Is+Enhanced+by+Combination+with+Paclitaxel+Chemotherapy&rft.au=Kelly%2C+Marcus+P%3BLee%2C+Fook+T%3BTahtis%2C+Kiki%3BSmyth%2C+Fiona+E%3BBrechbiel%2C+Martin+W%3BScott%2C+Andrew+M&rft.aulast=Kelly&rft.aufirst=Marcus&rft.date=2007-09-01&rft.volume=13&rft.issue=18&rft.spage=5604s&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Immunoblotting; Enzyme-linked immunosorbent assay; Physical characteristics; Apoptosis; Solid tumors; Monoclonal antibodies; Chemotherapy; Animal models; Tumors; DNA damage; minimal residual disease; Cytotoxicity; Malignancy; Paclitaxel; Confocal microscopy; Radioisotopes; Breast carcinoma ER - TY - JOUR T1 - Inflammatory Breast Cancer: Dynamic Contrast-enhanced MR in Patients Receiving Bevacizumab-Initial Experience AN - 19747556; 7560633 AB - PURPOSE: To retrospectively compare three dynamic contrast material-enhanced magnetic resonance (MR) imaging (dynamic MR imaging) analytic methods to determine the parameter or combination of parameters most strongly associated with changes in tumor microvasculature during treatment with bevacizumab alone and bevacizumab plus chemotherapy in patients with inflammatory or locally advanced breast cancer. MATERIALS AND METHODS: This study was conducted in accordance with the institutional review board of the National Cancer Institute and was compliant with the Privacy Act of 1974. Informed consent was obtained from all patients. Patients with inflammatory or locally advanced breast cancer were treated with one cycle of bevacizumab alone (cycle 1) followed by six cycles of combination bevacizumab and chemotherapy (cycles 2-7). Serial dynamic MR images were obtained, and the kinetic parameters measured by using three dynamic analytic MR methods (heuristic, Brix, and general kinetic models) and two region-of-interest strategies were compared by using two-sided statistical tests. A P value of .01 was required for significance. RESULTS: In 19 patients, with use of a whole-tumor region of interest, the authors observed a significant decrease in the median values of three parameters measured from baseline to cycle 1: forward transfer rate constant (K super(trans)) (-34% relative change, P = .003), backflow compartmental rate constant extravascular and extracellular to plasma (K sub(ep)) (-15% relative change, P < .001), and integrated area under the gadolinium concentration curve (IAUGC) at 180 seconds (-23% relative change, P = .009). A trend toward differences in the heuristic slope of the washout curve between responders and nonresponders to therapy was observed after cycle 1 (bevacizumab alone, P = .02). The median relative change in slope of the wash-in curve from baseline to cycle 4 was significantly different between responders and nonresponders (P = .009). CONCLUSION: The dynamic contrast-enhanced MR parameters K super(trans), K sub(ep), and IAUGC at 180 seconds appear to have the strongest association with early physiologic response to bevacizumab. Clinical trial registration no. NCT00016549 [copy ] RSNA, 2007 JF - Radiology AU - Thukral, Arpi AU - Thomasson, David M AU - Chow, Catherine K AU - Eulate, Reyes AU - Wedam, Suparna B AU - Gupta, Sandeep N AU - Wise, Betty J AU - Steinberg, Seth M AU - Liewehr, David J AU - Choyke, Peter L AU - Swain, Sandra M AD - Medical Oncology Branch (A.T., S.B.W., S. M. Swain), Molecular Imaging Program (R.E., P.L.C.), and Biostatistics and Data Management Section (S. M. Steinberg, D.J.L.), Center for Cancer Research, National Cancer Institute Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 727 EP - 735 PB - Radiological Society of North America, 820 Jorie Blvd. Oak Brook Illinois 60523-2251 USA VL - 244 IS - 3 SN - 0033-8419, 0033-8419 KW - Biotechnology and Bioengineering Abstracts KW - Microvasculature KW - Chemotherapy KW - Gadolinium KW - Magnetic resonance imaging KW - Statistical analysis KW - Tumors KW - Clinical trials KW - Models KW - Inflammation KW - Kinetics KW - Problem solving KW - Breast cancer KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19747556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Inflammatory+Breast+Cancer%3A+Dynamic+Contrast-enhanced+MR+in+Patients+Receiving+Bevacizumab-Initial+Experience&rft.au=Thukral%2C+Arpi%3BThomasson%2C+David+M%3BChow%2C+Catherine+K%3BEulate%2C+Reyes%3BWedam%2C+Suparna+B%3BGupta%2C+Sandeep+N%3BWise%2C+Betty+J%3BSteinberg%2C+Seth+M%3BLiewehr%2C+David+J%3BChoyke%2C+Peter+L%3BSwain%2C+Sandra+M&rft.aulast=Thukral&rft.aufirst=Arpi&rft.date=2007-09-01&rft.volume=244&rft.issue=3&rft.spage=727&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Inflammation; Breast cancer; Magnetic resonance imaging; Kinetics; Statistical analysis; Problem solving; Chemotherapy; Gadolinium; Models; Clinical trials; Tumors; Microvasculature ER - TY - JOUR T1 - Multicenter Study of Acetaminophen Hepatotoxicity Reveals the Importance of Biological Endpoints in Genomic Analyses AN - 19747162; 7561136 AB - Gene expression profiling is a widely used technique with data from the majority of published microarray studies being publicly available. These data are being used for meta-analyses and in silico discovery; however, the comparability of toxicogenomic data generated in multiple laboratories has not been critically evaluated. Using the power of prospective multilaboratory investigations, seven centers individually conducted a common toxicogenomics experiment designed to advance understanding of molecular pathways perturbed in liver by an acute toxic dose of N-acetyl-p-aminophenol (APAP) and to uncover reproducible genomic signatures of APAP-induced toxicity. The nonhepatotoxic APAP isomer N-acetyl-m-aminophenol was used to identify gene expression changes unique to APAP. Our data show that c-Myc is induced by APAP and that c-Myc-centered interactomes are the most significant networks of proteins associated with liver injury. Furthermore, sources of error and data variability among Centers and methods to accommodate this variability were identified by coupling gene expression with extensive toxicological evaluation of the toxic responses. We show that phenotypic anchoring of gene expression data is required for biologically meaningful analysis of toxicogenomic experiments. JF - Toxicological Sciences AU - Beyer, Richard P AU - Fry, Rebecca C AU - Lasarev, Michael R AU - McConnachie, Lisa A AU - Meira, Lisiane B AU - Palmer, Valerie S AU - Powell, Christine L AU - Ross, Pamela K AU - Bammler, Theo K AU - Bradford, Blair U AU - Cranson, Alex B AU - Cunningham, Michael L AU - Fannin, Rickie D AU - Higgins, Gregory M AU - Hurban, Patrick AU - Kayton, Robert J AU - Kerr, Kathleen F AU - Kosyk, Oksana AU - Lobenhofer, Edward K AU - Sieber, Stella O AU - Vliet, Portia A AU - Weis, Brenda K AU - Wolfinger, Russel AU - Woods, Courtney G AU - Freedman, Jonathan H AU - Linney, Elwood AU - Kaufmann, William K AU - Kavanagh, Terrance J AU - Paules, Richard S AU - Rusyn, Ivan AU - Samson, Leona D AU - Spencer, Peter S AU - Suk, William AU - Tennant, Raymond J AU - Zarbl, Helmut AD - University of Washington, Seattle, Washington 98195. Massachusetts Institute of Technology, Cambridge, Massachusetts 02139. Oregon Health & Science University, Portland, Oregon 97239. University of North Carolina, Chapel Hill, North Carolina 27599. National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Cogenics, a Division of Clinical Data, Inc., Morrisville, North Carolina 27560. SAS Institute, Inc., Cary, North Carolina 27513. Duke University Medical Center, Durham, North Carolina 27710. Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 326 EP - 337 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 1 SN - 1096-6080, 1096-6080 KW - Genetics Abstracts; Toxicology Abstracts KW - Gene expression KW - Data processing KW - Injuries KW - Reviews KW - Genomic analysis KW - Liver KW - Toxicity KW - Acetaminophen KW - hepatotoxicity KW - c-Myc protein KW - Isomers KW - X 24310:Pharmaceuticals KW - G 07710:Chemical Mutagenesis & Radiation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19747162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Mitochondrial+toxicity+in+hearts+of+CD-1+mice+following+perinatal+exposure+to+AZT%2C+3TC%2C+or+AZT%2F3TC+in+combination&rft.au=Chan%2C+Sherine+S+L%3BSantos%2C+Janine+H%3BMeyer%2C+Joel+N%3BMandavilli%2C+Bhaskar+S%3BCook+Jr%2C+Dennis+L%3BMcCash%2C+Consuelo+L%3BKissling%2C+Grace+E%3BNyska%2C+Abraham%3BFoley%2C+Julie+F%3Bvan+Houten%2C+Bennett%3BCopeland%2C+William+C%3BWalker%2C+Vernon+E%3BWitt%2C+Kristine+L%3BBishop%2C+Jack+B&rft.aulast=Chan&rft.aufirst=Sherine+S&rft.date=2007-05-01&rft.volume=48&rft.issue=3-4&rft.spage=190&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20191 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gene expression; Data processing; Injuries; Reviews; Genomic analysis; Liver; Toxicity; c-Myc protein; hepatotoxicity; Acetaminophen; Isomers ER - TY - JOUR T1 - Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in the Developing Male Wistar(Han) Rat. II: Chronic Dosing Causes Developmental Delay AN - 19747140; 7561125 AB - We have investigated whether fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes defects in the male reproductive system of the rat using chronically exposed rats to ensure continuous exposure of the fetus. Five- to six-week-old rats were exposed to control diet, or diet containing TCDD, to attain an average dose of 2.4, 8, and 46 ng TCDD/kg/day for 12 weeks, whereupon the rats were mated and allowed to litter; rats were switched to control diet after parturition. Male offsprings were allowed to develop until kills on PND70 (25 per group) or PND120 (all remaining animals). Offspring from the high-dose group showed an increase in total litter loss, and the number of animals alive on postnatal day (PND)4 in the high-dose group was similar to 26% less than control. The high and medium dose offsprings showed decreased weights at various ages. Balano-preputial separation (BPS) was significantly delayed in all three dose groups compared to control. There were no significant effects of maternal treatment when the offsprings were subjected to a functional observational battery or learning tests, with the exception that the high-dose group showed a deficit in motor activity. Twenty rats per group were mated to females, and there were no significant effects of maternal treatment on the fertility of these rats or on the F sub(1) or F sub(2) sex ratio. Sperm parameters at PND70 and 120 showed no significant effect of maternal treatment, with the exception that there was an increase in the proportion of abnormal sperm in the high-dose group at PND70; this is associated with the developmental delay in puberty in this dose group. There were no remarkable findings of maternal treatment on organ weights, with the exception that testis weights were reduced by similar to 10% at PND70 (but not PND120), and although the experiment was sufficiently powered to detect small changes, ventral prostate weight was not reduced. There were no significant effects of maternal treatment upon histopathological comparison of high-dose and control group organs. These data confirm that developmental exposure to TCDD shows no potent effect on adult sperm parameters or accessory sexual organs, but show that delay in BPS occurs after exposure to low doses of TCDD, and this is dependent upon whether TCDD is administered acutely or chronically. JF - Toxicological Sciences AU - Bell, David R AU - Clode, Sally AU - Fan, Ming Qi AU - Fernandes, Alwyn AU - Foster, Paul MD AU - Jiang, Tao AU - Loizou, George AU - MacNicoll, Alan AU - Miller, Brian G AU - Rose, Martin AU - Tran, Lang AU - White, Shaun AD - School of Biology, University of Nottingham, University Park, Nottingham, NG7 2RD, UK. Covance Laboratories Ltd, Otley Road, Harrogate, North Yorkshire, HG3 1PY UK. National Institute of Environmental Health Sciences, PO Box 12233 (MD E1-06), 111 TW Alexander Drive, Research Triangle Park, North Carolina 27709. Health and Safety Laboratory, Harpur Hill, Buxton, Derbyshire, SK17 9JN, UK. Central Science Laboratory, Environment, Food and Health, Sand Hutton, York, YO41 1LZ, UK. Institute of Occupational Medicine, Research Park North, Riccarton, Edinburgh, EH14 4AP, UK Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 224 EP - 233 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 1 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - Testes KW - Diets KW - Fertility KW - Age KW - Sex ratio KW - Parturition KW - TCDD KW - Toxicity KW - Sperm KW - Fetuses KW - Reproductive system KW - Motor activity KW - Observational learning KW - Progeny KW - Prostate KW - Puberty KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19747140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Toxicity+of+2%2C3%2C7%2C8-Tetrachlorodibenzo-p-dioxin+in+the+Developing+Male+Wistar%28Han%29+Rat.+II%3A+Chronic+Dosing+Causes+Developmental+Delay&rft.au=Bell%2C+David+R%3BClode%2C+Sally%3BFan%2C+Ming+Qi%3BFernandes%2C+Alwyn%3BFoster%2C+Paul+MD%3BJiang%2C+Tao%3BLoizou%2C+George%3BMacNicoll%2C+Alan%3BMiller%2C+Brian+G%3BRose%2C+Martin%3BTran%2C+Lang%3BWhite%2C+Shaun&rft.aulast=Bell&rft.aufirst=David&rft.date=2007-09-01&rft.volume=99&rft.issue=1&rft.spage=224&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Diets; Testes; Age; Fertility; Sex ratio; Parturition; TCDD; Sperm; Toxicity; Reproductive system; Fetuses; Motor activity; Progeny; Observational learning; Prostate; Puberty ER - TY - JOUR T1 - Differential Fungicidal Activities of Amphotericin B and Voriconazole against Aspergillus Species Determined by Microbroth Methodology AN - 19741098; 7554007 AB - Antifungal agents may differ in their fungicidal activities against Aspergillus spp. In order to compare the fungicidal activities of voriconazole and amphotericin B against 40 isolates of Aspergillus fumigatus, A. flavus, and A. terreus, we developed a new microbroth colorimetric method for assessing fungicidal activities and determining minimal fungicidal concentrations (MFCs). This methodology follows the antifungal susceptibility testing reference method M-38A for MIC determination. After drug removal and addition of fresh medium, growth of viable conidia adhering to the bottoms of the microtitration wells was assessed by a colorimetric assay of metabolic activity after 24 h of incubation. The new method was faster (six times), reproducible (92 to 97%), and in agreement with culture-based MFCs (91 to 100%). Differential fungicidal activities of voriconazole and amphotericin B were found among the three Aspergillus species, with A. fumigatus and A. flavus having the lowest (1 and 2 mg/liter, respectively) and A. terreus the highest (>16 mg/liter) median amphotericin B MFCs; A. flavus had a lower median voriconazole MFC (4 mg/liter) than the other species (>8 mg/liter; P 4) against 94% of A. fumigatus and 84% of A. terreus isolates. The new methodology revealed a concentration-dependent sigmoid pattern of fungicidal effects, indicating that fungicidal activity is not an all-or-nothing phenomenon and that some degree of fungicidal action can be found even for agents considered fungistatic based on the MFC/MIC ratio. JF - Antimicrobial Agents & Chemotherapy AU - Meletiadis, Joseph AU - Antachopoulos, Charalampos AU - Stergiopoulou, Theodouli AU - Pournaras, Spyros AU - Roilides, Emmanuel AU - Walsh, Thomas J AD - Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland. Department of Clinical Microbiology, University of Thessalia, Larissa, Greece. Third Department of Pediatrics, Aristotle University, Hippokration Hospital, Thessaloniki, Greece Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 3329 EP - 3337 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 51 IS - 9 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Amphotericin B KW - Antifungal agents KW - Aspergillus flavus KW - Aspergillus fumigatus KW - Fungicidal activity KW - Voriconazole KW - Colorimetry KW - Conidia KW - Minimum inhibitory concentration KW - Drugs KW - K 03340:Effects of Physical & Chemical Factors KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19741098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Differential+Fungicidal+Activities+of+Amphotericin+B+and+Voriconazole+against+Aspergillus+Species+Determined+by+Microbroth+Methodology&rft.au=Meletiadis%2C+Joseph%3BAntachopoulos%2C+Charalampos%3BStergiopoulou%2C+Theodouli%3BPournaras%2C+Spyros%3BRoilides%2C+Emmanuel%3BWalsh%2C+Thomas+J&rft.aulast=Meletiadis&rft.aufirst=Joseph&rft.date=2007-09-01&rft.volume=51&rft.issue=9&rft.spage=3329&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Amphotericin B; Antifungal agents; Voriconazole; Fungicidal activity; Colorimetry; Conidia; Drugs; Minimum inhibitory concentration; Aspergillus flavus; Aspergillus fumigatus ER - TY - JOUR T1 - Phase I Study of SS1P, a Recombinant Anti-Mesothelin Immunotoxin Given as a Bolus I.V. Infusion to Patients with Mesothelin-Expressing Mesothelioma, Ovarian, and Pancreatic Cancers AN - 19739561; 7556257 AB - PURPOSE: To determine the toxicities, maximum tolerated dose (MTD) and pharmacokinetics of the recombinant immunotoxin SS1P (anti-mesothelin dsFv-PE38) in patients with mesothelin-expressing cancers. Experimental Design: SS1P given as a 30-min i.v. infusion every other day (QOD) for six or three doses was administered to 34 patients with advanced mesothelioma (n = 20), ovarian (n = 12), and pancreatic (n = 2) cancer. RESULTS: The initial cohort of 17 patients received SS1P QOD x 6 doses and the MTD was 18 mu g/kg/dose. Dose-limiting toxicities (DLT) included grade 3 uticaria (one patient) and grade 3 vascular leak syndrome (two patients). To allow further SS1P dose escalation, 17 patients were treated on the QOD x 3 schedule and the MTD was 45 mu g/kg/dose. The DLT was grade 3 pleuritis and was seen in two of two patients treated at a dose of 60 mu g/kg and in one of nine patients treated at a dose of 45 mu g/kg. At the MTD of 45 mu g/kg, the mean C sub(max) of SS1P was 483 ng/mL and half-life was 466 min. Of the 33 evaluable patients treated, 4 had minor responses, 19 had stable disease (including 2 with resolution of ascites), and 10 had progressive disease. CONCLUSIONS: SS1P is well tolerated with pleuritis as the DLT at the highest dose level. Evidence of clinical activity was noted in a group of heavily pretreated patients. Phase II clinical trials of SS1P are being planned for malignant mesothelioma and other mesothelin-expressing malignancies. JF - Clinical Cancer Research AU - Hassan, Raffit AU - Bullock, Susie AU - Premkumar, Ahalya AU - Kreitman, Robert J AU - Kindler, Hedy AU - Willingham, Mark C AU - Pastan, Ira AD - Authors' Affiliations: Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute and Clinical Center, NIH, Bethesda, Maryland Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - 5144 EP - 5149 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 13 IS - 17 SN - 1078-0432, 1078-0432 KW - Toxicology Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Malignancy KW - Pleurisy KW - vascular leak syndrome KW - Ascites KW - Pancreatic cancer KW - mesothelioma KW - Toxicity KW - Clinical trials KW - Immunotoxins KW - Pharmacokinetics KW - W 30925:Genetic Engineering KW - X 24310:Pharmaceuticals KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19739561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Phase+I+Study+of+SS1P%2C+a+Recombinant+Anti-Mesothelin+Immunotoxin+Given+as+a+Bolus+I.V.+Infusion+to+Patients+with+Mesothelin-Expressing+Mesothelioma%2C+Ovarian%2C+and+Pancreatic+Cancers&rft.au=Hassan%2C+Raffit%3BBullock%2C+Susie%3BPremkumar%2C+Ahalya%3BKreitman%2C+Robert+J%3BKindler%2C+Hedy%3BWillingham%2C+Mark+C%3BPastan%2C+Ira&rft.aulast=Hassan&rft.aufirst=Raffit&rft.date=2007-09-01&rft.volume=13&rft.issue=17&rft.spage=5144&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Malignancy; Pleurisy; vascular leak syndrome; Ascites; Pancreatic cancer; mesothelioma; Toxicity; Clinical trials; Pharmacokinetics; Immunotoxins ER - TY - JOUR T1 - Effects of Gamma Radiation on Fc epsilon RI and TLR-Mediated Mast Cell Activation AN - 19739019; 7558709 AB - Ionizing gamma radiation has several therapeutic indications including bone marrow transplantation and tumor ablation. Among immune cells, susceptibility of lymphocytes to gamma radiation is well known. However, there is little information on the effects of gamma radiation on mast cells, which are important in both innate and acquired immunity. Previous studies have suggested that mast cells may release histamine in response to high doses of gamma radiation, whereas other reports suggest that mast cells are relatively radioresistant. No strong link has been established between gamma radiation and its effect on mast cell survival and activation. We examined both human and murine mast cell survival and activation, including mechanisms related to innate and acquired immune responses following gamma radiation. Data revealed that human and murine mast cells were resistant to gamma radiation-induced cytotoxicity and, importantly, that irradiation did not directly induce beta -hexosaminidase release. Instead, a transient attenuation of IgE-mediated beta -hexosaminidase release and cytokine production was observed which appeared to be the result of reactive oxygen species formation after irradiation. Mast cells retained the ability to phagocytose Escherichia coli particles and respond to TLR ligands as measured by cytokine production after irradiation. In vivo, there was no decrease in mast cell numbers in skin of irradiated mice. Additionally, mast cells retained the ability to respond to Ag in vivo as measured by passive cutaneous anaphylaxis in mice after irradiation. Mast cells are thus resistant to the cytotoxic effects and alterations in function after irradiation and, despite a transient inhibition, ultimately respond to innate and acquired immune activation signals. JF - Journal of Immunology AU - Soule, Benjamin P AU - Brown, Jared M AU - Kushnir-Sukhov, Nataliya M AU - Simone, Nicole L AU - Mitchell, James B AU - Metcalfe, Dean D AD - Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - 3276 EP - 3286 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 179 IS - 5 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Cell survival KW - Skin KW - double prime Fc receptors KW - Bone marrow KW - Mast cells KW - Immunity KW - Passive cutaneous anaphylaxis KW - Lymphocytes KW - beta N- double prime Acetylhexosaminidase KW - Cell activation KW - Histamine KW - Cytotoxicity KW - Reactive oxygen species KW - Allografts KW - Escherichia coli KW - gamma Radiation KW - Cytokines KW - Bone marrow transplantation KW - F 06955:Immunomodulation & Immunopharmacology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19739019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Effects+of+Gamma+Radiation+on+Fc+epsilon+RI+and+TLR-Mediated+Mast+Cell+Activation&rft.au=Soule%2C+Benjamin+P%3BBrown%2C+Jared+M%3BKushnir-Sukhov%2C+Nataliya+M%3BSimone%2C+Nicole+L%3BMitchell%2C+James+B%3BMetcalfe%2C+Dean+D&rft.aulast=Soule&rft.aufirst=Benjamin&rft.date=2007-09-01&rft.volume=179&rft.issue=5&rft.spage=3276&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell survival; Skin; double prime Fc receptors; Bone marrow; Mast cells; Lymphocytes; Passive cutaneous anaphylaxis; Immunity; Histamine; Cell activation; beta N- double prime Acetylhexosaminidase; Cytotoxicity; Reactive oxygen species; Allografts; gamma Radiation; Cytokines; Bone marrow transplantation; Escherichia coli ER - TY - JOUR T1 - Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in the Developing Male Wistar(Han) Rat. I: No Decrease in Epididymal Sperm Count after a Single Acute Dose AN - 19736470; 7561124 AB - It has been reported that fetal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes defects in the male reproductive system of the rat. We set out to replicate and extend these effects using a robust experimental design. Groups of 75 (control vehicle) or 55 (50, 200, or 1000 ng of TCDD/kg bodyweight) female Wistar(Han) rats were exposed to TCDD on gestational day (GD)15, then allowed to litter. The high-dose group dams showed no sustained weight loss compared to control, but four animals had total litter loss. Pups in the high-dose group showed reduced body weight up till day 21, and pups in the medium dose group showed reduced body weight in the first week postpartum. Balano-preputial separation was significantly delayed in the high-dose group male offspring. There were no significant effects of treatment when the offspring were subjected to a functional observational battery or mated with females to assess reproductive capability. Twenty-five males per group were killed on postnatal day (PND) 70, and similar to 60 animals per group ( similar to 30 for the high-dose group) on PND120 to assess seminology and other end points. At PND120, the two highest dose groups showed a statistically significant elevation of sperm counts, compared to control; however, this effect was small ( similar to 30%), within the normal range of sperm counts for this strain of rat, was not reflected in testicular spermatid counts nor PND70 data, and is therefore postulated to have no biological significance. Although there was an increase in the proportion of abnormal sperm at PND70, seminology parameters were otherwise unremarkable. Testis weights in the high-dose group were slightly decreased at PND70 and 120, and at PND120, brain weights were decreased in the high-dose group, liver to body weight ratios were increased for all three dose groups, with an increase in inflammatory cell foci in the epididymis in the high-dose group. These data show that TCDD is a potent developmental toxin after exposure of the developing fetus but that acute developmental exposure to TCDD on GD15 caused no decrease in sperm counts. JF - Toxicological Sciences AU - Bell, David R AU - Clode, Sally AU - Fan, Ming Qi AU - Fernandes, Alwyn AU - Foster, Paul MD AU - Jiang, Tao AU - Loizou, George AU - MacNicoll, Alan AU - Miller, Brian G AU - Rose, Martin AU - Tran, Lang AU - White, Shaun AD - School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK. Covance Laboratories Ltd, Otley Road, Harrogate, North Yorkshire, HG3 1PY, UK. National Institute of Environmental Health Sciences, PO Box 12233 (MD E1-06), 111 TW Alexander Drive, Research Triangle Park, North Carolina 27709. Health and Safety Laboratory, Harpur Hill, Buxton, Derbyshire, SK17 9JN, UK. Central Science Laboratory, Environment, Food and Health, Sand Hutton, York, YO41 1LZ, UK. Institute of Occupational Medicine, Research Park North, Riccarton, Edinburgh, EH14 4AP, UK Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 214 EP - 223 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 1 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - Testes KW - Epididymis KW - Brain KW - Statistical analysis KW - TCDD KW - Toxicity KW - Sperm KW - Toxins KW - Fetuses KW - Reproductive system KW - Inflammation KW - Postpartum KW - Body weight KW - Spermatids KW - Liver KW - Progeny KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19736470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Toxicity+of+2%2C3%2C7%2C8-Tetrachlorodibenzo-p-dioxin+in+the+Developing+Male+Wistar%28Han%29+Rat.+I%3A+No+Decrease+in+Epididymal+Sperm+Count+after+a+Single+Acute+Dose&rft.au=Bell%2C+David+R%3BClode%2C+Sally%3BFan%2C+Ming+Qi%3BFernandes%2C+Alwyn%3BFoster%2C+Paul+MD%3BJiang%2C+Tao%3BLoizou%2C+George%3BMacNicoll%2C+Alan%3BMiller%2C+Brian+G%3BRose%2C+Martin%3BTran%2C+Lang%3BWhite%2C+Shaun&rft.aulast=Bell&rft.aufirst=David&rft.date=2007-09-01&rft.volume=99&rft.issue=1&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Testes; Epididymis; Statistical analysis; Brain; TCDD; Sperm; Toxicity; Reproductive system; Fetuses; Toxins; Inflammation; Postpartum; Spermatids; Body weight; Liver; Progeny ER - TY - JOUR T1 - Multicopy plasmid modification with phage lambda Red recombineering AN - 19540422; 8242091 AB - Recombineering, in vivo genetic engineering using the bacteriophage lambda Red generalized recombination system, was used to create various modifications of a multicopy plasmid derived from pBR322. All genetic modifications possible on the Escherichia coli chromosome and on bacterial artificial chromosomes (BACs) are also possible on multicopy plasmids and are obtained with similar frequencies to their chromosomal counterparts, including creation of point mutations (5-10% unselected frequency), deletions and substitutions. Parental and recombinant plasmids are nearly always present as a mixture following recombination, and circular multimeric plasmid molecules are often generated during the recombineering. JF - Plasmid AU - Thomason, L C AU - Costantino, N AU - Shaw, D V AU - Court, D L AD - Building 539, Room 243, National Cancer Institute at Frederick, Frederick, MD 21702, USA, lthomason@ncifcrf.gov Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 148 EP - 158 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 58 IS - 2 SN - 0147-619X, 0147-619X KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Phages KW - Bacterial artificial chromosomes KW - Recombination KW - Chromosomes KW - Genetic engineering KW - Chromosome deletion KW - Point mutation KW - Escherichia coli KW - Phage l KW - Plasmids KW - J 02410:Animal Diseases KW - W 30925:Genetic Engineering KW - V 22410:Animal Diseases KW - G 07760:Viruses & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19540422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Plasmid&rft.atitle=Multicopy+plasmid+modification+with+phage+lambda+Red+recombineering&rft.au=Thomason%2C+L+C%3BCostantino%2C+N%3BShaw%2C+D+V%3BCourt%2C+D+L&rft.aulast=Thomason&rft.aufirst=L&rft.date=2007-09-01&rft.volume=58&rft.issue=2&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Plasmid&rft.issn=0147619X&rft_id=info:doi/10.1016%2Fj.plasmid.2007.03.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Bacterial artificial chromosomes; Phages; Recombination; Chromosomes; Genetic engineering; Point mutation; Chromosome deletion; Plasmids; Escherichia coli; Phage l DO - http://dx.doi.org/10.1016/j.plasmid.2007.03.001 ER - TY - JOUR T1 - Cutting Edge: Peyer's Patch Plasmacytoid Dendritic Cells (pDCs) Produce Low Levels of Type I Interferons: Possible Role for IL-10, TGF beta , and Prostaglandin E sub(2) in Conditioning a Unique Mucosal pDC Phenotype AN - 19458168; 7558645 AB - The organized lymphoid tissues of the intestine likely play an important role in the balance between tolerance harmless mucosal Ags and commensal bacteria and immunity to mucosal pathogens. We examined the phenotype and function of plasmacytoid dendritic cells (pDCs) from murine Peyer's patches (PPs). When stimulated with CpG-enriched oligodeoxynucleotides in vitro, PPs and spleen pDCs made equivalent levels of IL-12, yet PP pDCs were incapable of producing significant levels of type I IFNs. Three regulatory factors associated with mucosal tissues, PGE sub(2), IL-10, and TGF beta , inhibited the ability of spleen pDCs to produce type I IFN in a dose-dependent fashion. These studies suggest that mucosal factors may regulate the production of type I IFN as well as IL-12 by pDCs. In the intestine, this may be beneficial in preventing harmful innate and adaptive immune responses to commensal microorganisms. JF - Journal of Immunology AU - Contractor, Nikhat AU - Louten, Jennifer AU - Kim, Leesun AU - Biron, Christine A AU - Kelsall, Brian L AD - Mucosal Immunobiology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892. Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912. Wyeth Nutrition, Collegeville, PA 19426. Schering-Plough Biopharma, Palo Alto, CA 94304 Y1 - 2007/09/01/ PY - 2007 DA - 2007 Sep 01 SP - 2690 EP - 2694 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 179 IS - 5 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Peyer's patches KW - Mucosal immunity KW - Mucosa KW - Commensals KW - Spleen KW - Pathogens KW - Prostaglandin E2 KW - Oligonucleotides KW - Immunological tolerance KW - Interleukin 10 KW - Lymphoid tissue KW - Dendritic cells KW - Interleukin 12 KW - Interferon KW - Transforming growth factor- beta KW - Intestine KW - Microorganisms KW - Immune response KW - A 01490:Miscellaneous KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19458168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Cutting+Edge%3A+Peyer%27s+Patch+Plasmacytoid+Dendritic+Cells+%28pDCs%29+Produce+Low+Levels+of+Type+I+Interferons%3A+Possible+Role+for+IL-10%2C+TGF+beta+%2C+and+Prostaglandin+E+sub%282%29+in+Conditioning+a+Unique+Mucosal+pDC+Phenotype&rft.au=Contractor%2C+Nikhat%3BLouten%2C+Jennifer%3BKim%2C+Leesun%3BBiron%2C+Christine+A%3BKelsall%2C+Brian+L&rft.aulast=Contractor&rft.aufirst=Nikhat&rft.date=2007-09-01&rft.volume=179&rft.issue=5&rft.spage=2690&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Peyer's patches; Mucosal immunity; Mucosa; Commensals; Spleen; Prostaglandin E2; Pathogens; Immunological tolerance; Oligonucleotides; Lymphoid tissue; Interleukin 10; Interferon; Interleukin 12; Dendritic cells; Transforming growth factor- beta; Microorganisms; Intestine; Immune response ER - TY - JOUR T1 - OC144: Clinical significance of the presence of amniotic fluid sludge in patients with cervical cerclage AN - 19283404; 8634598 AB - Abstract not available. JF - Ultrasound in Obstetrics and Gynecology AU - Kusanovic, J P AU - Romero, R AU - Espinoza, J AU - Goncalves, L F AU - Gotsch, F AU - Camacho, N AU - Lee, W AU - Erez, O AU - Schoen, M L AU - Hassan, S AD - Perinatology Research Branch, Intramural Division, National Institute of Child Health and Human Development, NIH, DHHS, United States Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 411 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 30 IS - 4 SN - 0960-7692, 0960-7692 KW - Biotechnology and Bioengineering Abstracts KW - Amniotic fluid KW - Gynecology KW - Sludges KW - Ultrasound KW - Obstetrics KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19283404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=OC144%3A+Clinical+significance+of+the+presence+of+amniotic+fluid+sludge+in+patients+with+cervical+cerclage&rft.au=Kusanovic%2C+J+P%3BRomero%2C+R%3BEspinoza%2C+J%3BGoncalves%2C+L+F%3BGotsch%2C+F%3BCamacho%2C+N%3BLee%2C+W%3BErez%2C+O%3BSchoen%2C+M+L%3BHassan%2C+S&rft.aulast=Kusanovic&rft.aufirst=J&rft.date=2007-09-01&rft.volume=30&rft.issue=4&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=09607692&rft_id=info:doi/10.1002%2Fuog.4250 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Obstetrics; Amniotic fluid; Gynecology; Sludges; Ultrasound DO - http://dx.doi.org/10.1002/uog.4250 ER - TY - JOUR T1 - Inter- alpha -Trypsin Inhibitor Attenuates Complement Activation and Complement-Induced Lung Injury AN - 17279455; 7614922 AB - Complement activation is a central component of inflammation and sepsis and can lead to significant tissue injury. Complement factors are serum proteins that work through a cascade of proteolytic reactions to amplify proinflammatory signals. Inter- alpha -trypsin inhibitor (IaI) is an abundant serum protease inhibitor that contains potential complement-binding domains, and has been shown to improve survival in animal sepsis models. We hypothesized that IaI can bind complement and inhibit complement activation, thus ameliorating complement-dependent inflammation. We evaluated this hypothesis with in vitro complement activation assays and in vivo in a murine model of complement-dependent lung injury. We found that IaI inhibited complement activation through the classical and alternative pathways, inhibited complement-dependent phagocytosis in vitro, and reduced complement-dependent lung injury in vivo. This novel function of IaI provides a mechanistic explanation for its observed salutary effects in sepsis and opens new possibilities for its use as a treatment agent in inflammatory diseases. JF - Journal of Immunology AU - Garantziotis, Stavros AU - Hollingsworth, John W AU - Ghanayem, Rami B AU - Timberlake, Sarah AU - Zhuo, Lisheng AU - Kimata, Koji AU - Schwartz, David A AD - Department of Medicine, Duke University Medical Center, Durham, NC 27710. National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. North Carolina State University, Raleigh, NC 27695. Institute for Molecular Science of Medicine, Aichi Medical University, Aichi, Japan Y1 - 2007/09// PY - 2007 DA - Sep 2007 SP - 4187 EP - 4192 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 179 IS - 6 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Proteolysis KW - Injuries KW - Proteinase inhibitors KW - Animal models KW - Survival KW - Serum proteins KW - Inflammation KW - Alternative pathway KW - Sepsis KW - Inflammatory diseases KW - Lung KW - Complement activation KW - Phagocytosis KW - J 02350:Immunology KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17279455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Inter-+alpha+-Trypsin+Inhibitor+Attenuates+Complement+Activation+and+Complement-Induced+Lung+Injury&rft.au=Garantziotis%2C+Stavros%3BHollingsworth%2C+John+W%3BGhanayem%2C+Rami+B%3BTimberlake%2C+Sarah%3BZhuo%2C+Lisheng%3BKimata%2C+Koji%3BSchwartz%2C+David+A&rft.aulast=Garantziotis&rft.aufirst=Stavros&rft.date=2007-09-01&rft.volume=179&rft.issue=6&rft.spage=4187&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Proteolysis; Injuries; Proteinase inhibitors; Animal models; Survival; Inflammation; Serum proteins; Alternative pathway; Sepsis; Inflammatory diseases; Lung; Complement activation; Phagocytosis ER - TY - JOUR T1 - Gene expression profiling reveals different pathways related to Abl and other genes that cooperate with c-Myc in a model of plasma cell neoplasia. AN - 68428160; 17764563 AB - To elucidate the genes involved in the neoplastic transformation of B cells, global gene expression profiles were generated using Affymetrix U74Av2 microarrays, containing 12,488 genes, for four different groups of mouse B-cell lymphomas and six subtypes of pristane-induced mouse plasma cell tumors, three of which developed much earlier than the others. Unsupervised hierarchical cluster analysis exhibited two main sub-clusters of samples: a B-cell lymphoma cluster and a plasma cell tumor cluster with subclusters reflecting mechanism of induction. This report represents the first step in using global gene expression to investigate molecular signatures related to the role of cooperating oncogenes in a model of Myc-induced carcinogenesis. Within a single subgroup, e.g., ABPCs, plasma cell tumors that contained typical T(12;15) chromosomal translocations did not display gene expression patterns distinct from those with variant T(6;15) translocations, in which the breakpoint was in the Pvt-1 locus, 230 kb 3' of c-Myc, suggesting that c-Myc activation was the initiating factor in both. When integrated with previously published Affymetrix array data from human multiple myelomas, the IL-6-transgenic subset of mouse plasma cell tumors clustered more closely with MM1 subsets of human myelomas, slow-appearing plasma cell tumors clustered together with MM2, while plasma cell tumors accelerated by v-Abl clustered with the more aggressive MM3-MM4 myeloma subsets. Slow-appearing plasma cell tumors expressed Socs1 and Socs2 but v-Abl-accelerated plasma cell tumors expressed 4-5 times as much. Both v-Abl-accelerated and non-v-Abl-associated tumors exhibited phosphorylated STAT 1 and 3, but only v-Abl-accelerated plasma cell tumors lost viability and STAT 1 and 3 phosphorylation when cultured in the presence of the v-Abl kinase inhibitor, STI-571. These data suggest that the Jak/Stat pathway was critical in the transformation acceleration by v-Abl and that v-Abl activity remained essential throughout the life of the tumors, not just in their acceleration. A different pathway appears to predominate in the more slowly arising plasma cell tumors. Gene expression profiling differentiates not only B-cell lymphomas from plasma cell tumors but also distinguishes slow from accelerated plasma cell tumors. These data and those obtained from the sensitivity of v-Abl-accelerated plasma cell tumors and their phosphorylated STAT proteins indicate that these similar tumors utilize different signaling pathways but share a common initiating genetic lesion, a c-Myc-activating chromosome translocation. JF - BMC genomics AU - Park, Eun Sung AU - Shaughnessy, John D AU - Gupta, Shalu AU - Wang, Hongyang AU - Lee, Ju-Seog AU - Woo, Hyun Goo AU - Zhan, Fenghuang AU - Owens, James D AU - Potter, Michael AU - Janz, Siegfried AU - Mushinski, J Frederic AD - Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. espark@mdanderson.org Y1 - 2007/08/31/ PY - 2007 DA - 2007 Aug 31 SP - 302 VL - 8 KW - Benzamides KW - 0 KW - Piperazines KW - Pyrimidines KW - STAT Transcription Factors KW - Imatinib Mesylate KW - 8A1O1M485B KW - Index Medicus KW - Animals KW - Multiple Myeloma -- genetics KW - Humans KW - Pyrimidines -- pharmacology KW - Cell Line, Tumor KW - Mice KW - STAT Transcription Factors -- antagonists & inhibitors KW - Mice, Inbred BALB C KW - Piperazines -- pharmacology KW - Models, Biological KW - Lymphoma, B-Cell -- metabolism KW - Gene Expression Profiling KW - Signal Transduction -- genetics KW - Gene Expression Regulation, Neoplastic KW - Neoplasms, Plasma Cell -- genetics KW - Genes, myc KW - Genes, abl UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68428160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+genomics&rft.atitle=Gene+expression+profiling+reveals+different+pathways+related+to+Abl+and+other+genes+that+cooperate+with+c-Myc+in+a+model+of+plasma+cell+neoplasia.&rft.au=Park%2C+Eun+Sung%3BShaughnessy%2C+John+D%3BGupta%2C+Shalu%3BWang%2C+Hongyang%3BLee%2C+Ju-Seog%3BWoo%2C+Hyun+Goo%3BZhan%2C+Fenghuang%3BOwens%2C+James+D%3BPotter%2C+Michael%3BJanz%2C+Siegfried%3BMushinski%2C+J+Frederic&rft.aulast=Park&rft.aufirst=Eun&rft.date=2007-08-31&rft.volume=8&rft.issue=&rft.spage=302&rft.isbn=&rft.btitle=&rft.title=BMC+genomics&rft.issn=1471-2164&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-06 N1 - Date created - 2007-10-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Immunol. 2002 Mar;3(3):288-94 [11836527] Blood. 2002 Mar 1;99(5):1745-57 [11861292] Oncogene. 2002 Jun 27;21(28):4351-62 [12080466] Blood. 2002 Sep 15;100(6):2175-86 [12200383] Int J Cancer. 2002 Oct 10;101(5):423-6 [12216069] Blood. 2003 Feb 1;101(3):1128-40 [12393520] Blood. 2003 Apr 1;101(7):2784-8 [12456503] Blood. 2003 May 15;101(10):4013-21 [12543863] Blood. 2003 Jul 15;102(2):592-600 [12663452] Immunol Rev. 2003 Aug;194:19-28 [12846804] Immunol Rev. 2003 Aug;194:177-95 [12846815] Cancer Cell. 2003 Sep;4(3):223-38 [14522256] J Clin Invest. 2004 Jun;113(12):1763-73 [15199411] Mol Cell. 2004 Aug 13;15(3):329-41 [15304214] Science. 1973 Nov 9;182(4112):592-4 [4355680] Adv Cancer Res. 1986;47:189-234 [3096089] Proc Natl Acad Sci U S A. 1988 Aug;85(16):6067-71 [3137564] Proc Natl Acad Sci U S A. 1989 Oct;86(19):7547-51 [2798426] Proc Natl Acad Sci U S A. 1989 Dec;86(24):9941-5 [2690079] Mol Cell Biol. 1990 Aug;10(8):4365-9 [2164639] Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8735-9 [1924333] Carcinogenesis. 1992 Oct;13(10):1681-97 [1423827] Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7361-5 [8346257] Nat Med. 1996 May;2(5):561-6 [8616716] Nat Genet. 2004 Dec;36(12):1306-11 [15565109] Bioinformatics. 2004 Dec 12;20(18):3710-5 [15297299] Cell Cycle. 2004 Dec;3(12):1486-8 [15611644] Cancer Res. 2005 Feb 15;65(4):1306-15 [15735016] Cancer Res. 2005 Sep 1;65(17):7644-52 [16140930] Leukemia. 2006 Jun;20(6):1047-54 [16598311] Blood. 2006 Sep 15;108(6):2020-8 [16728703] Oncogene. 2000 May 15;19(21):2523-31 [10851051] Leukemia. 2000 Jun;14(6):1127-35 [10865979] Neoplasia. 1999 Aug;1(3):241-52 [10935479] N Engl J Med. 2001 Apr 5;344(14):1031-7 [11287972] Nat Immunol. 2001 Dec;2(12):1103-8 [11725300] Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1509-14 [11805288] Methods. 2001 Dec;25(4):402-8 [11846609] Curr Opin Hematol. 2002 Jul;9(4):333-8 [12042708] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Endogenous erythropoietin signaling is required for normal neural progenitor cell proliferation. AN - 68204986; 17604282 AB - Erythropoietin (Epo) and its receptor (EpoR), critical for erythropoiesis, are expressed in the nervous system. Prior to death in utero because of severe anemia EpoR-null mice have fewer neural progenitor cells, and differentiated neurons are markedly sensitive to hypoxia, suggesting that during development Epo stimulates neural cell proliferation and prevents neuron apoptosis by promoting oxygen delivery to brain or by direct interaction with neural cells. Here we present evidence that neural progenitor cells express EpoR at higher levels compared with mature neurons; that Epo stimulates proliferation of embryonic neural progenitor cells; and that endogenous Epo contributes to neural progenitor cell proliferation and maintenance. EpoR-null mice were rescued with selective EpoR expression driven by the endogenous EpoR promoter in hematopoietic tissue but not in brain. Although these mice exhibited normal hematopoiesis and erythrocyte production and survived to adulthood, neural cell proliferation and viability were affected. Embryonic brain exhibited increased neural cell apoptosis, and neural cell proliferation was reduced in the adult hippocampus and subventricular zone. Neural cells from these animals were more sensitive to hypoxia/glutamate neurotoxicity than normal neurons in culture and in vivo. These observations demonstrate that endogenous Epo/EpoR signaling promotes cell survival in embryonic brain and contributes to neural cell proliferation in adult brain in regions associated with neurogenesis. Therefore, Epo exerts extra-hematopoietic function and contributes directly to brain development, maintenance, and repair by promoting cell survival and proliferation independent of insult, injury, or ischemia. JF - The Journal of biological chemistry AU - Chen, Zhi-Yong AU - Asavaritikrai, Pundit AU - Prchal, Josef T AU - Noguchi, Constance Tom AD - Molecular Medicine Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-1822, USA. Y1 - 2007/08/31/ PY - 2007 DA - 2007 Aug 31 SP - 25875 EP - 25883 VL - 282 IS - 35 SN - 0021-9258, 0021-9258 KW - Receptors, Erythropoietin KW - 0 KW - Erythropoietin KW - 11096-26-7 KW - Index Medicus KW - Signal Transduction -- physiology KW - Promoter Regions, Genetic -- physiology KW - Animals KW - Mice, Mutant Strains KW - Erythropoiesis -- physiology KW - Hypoxia-Ischemia, Brain -- pathology KW - Organ Specificity -- physiology KW - Mice KW - Hypoxia-Ischemia, Brain -- metabolism KW - Cell Hypoxia KW - Cell Survival -- physiology KW - Stem Cells -- cytology KW - Neurons -- metabolism KW - Receptors, Erythropoietin -- metabolism KW - Cell Differentiation -- physiology KW - Brain -- cytology KW - Apoptosis -- physiology KW - Neurons -- cytology KW - Brain -- embryology KW - Brain -- metabolism KW - Stem Cells -- metabolism KW - Receptors, Erythropoietin -- deficiency KW - Cell Proliferation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68204986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Endogenous+erythropoietin+signaling+is+required+for+normal+neural+progenitor+cell+proliferation.&rft.au=Chen%2C+Zhi-Yong%3BAsavaritikrai%2C+Pundit%3BPrchal%2C+Josef+T%3BNoguchi%2C+Constance+Tom&rft.aulast=Chen&rft.aufirst=Zhi-Yong&rft.date=2007-08-31&rft.volume=282&rft.issue=35&rft.spage=25875&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-29 N1 - Date created - 2007-08-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Fabry Disease: What Pediatric Nephrologists should Know? T2 - 14th Congress of the International Pediatric Nephrology Association (IPNA 2007) AN - 39422996; 4646330 JF - 14th Congress of the International Pediatric Nephrology Association (IPNA 2007) AU - Cho, M Y1 - 2007/08/31/ PY - 2007 DA - 2007 Aug 31 KW - Pediatrics KW - Fabry's disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39422996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Congress+of+the+International+Pediatric+Nephrology+Association+%28IPNA+2007%29&rft.atitle=Fabry+Disease%3A+What+Pediatric+Nephrologists+should+Know%3F&rft.au=Cho%2C+M&rft.aulast=Cho&rft.aufirst=M&rft.date=2007-08-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Congress+of+the+International+Pediatric+Nephrology+Association+%28IPNA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ipna2007.com/final_programme/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Preeclampsia and maternal breast cancer risk by offspring gender: do elevated androgen concentrations play a role? AN - 954574550; 13760132 AB - Among older mothers, preeclampsia in the first pregnancy was associated with a reduction in maternal breast cancer risk that was significantly more pronounced in women bearing male than female infants. Androgen concentrations in male, preeclamptic pregnancies were consistent with the hypothesis that elevated pregnancy androgens might mediate this apparent modifying effect of fetal gender.British Journal of Cancer (2007) 97, 688-690. doi:10.1038/sj.bjc.6603921 www.bjcancer.com Published online 7 August 2007 JF - British Journal of Cancer AU - Troisi, R AU - Innes, K E AU - Roberts, J M AU - Hoover, R N AD - [1] 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA [2] 2 Department of Community and Family Medicine, Dartmouth Medical School, Hanover, NH, USA Y1 - 2007/08/28/ PY - 2007 DA - 2007 Aug 28 SP - 688 EP - 690 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 97 IS - 5 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - Cancer KW - Pregnancy KW - Gender KW - Breast cancer KW - offspring KW - Infants KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954574550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Preeclampsia+and+maternal+breast+cancer+risk+by+offspring+gender%3A+do+elevated+androgen+concentrations+play+a+role%3F&rft.au=Troisi%2C+R%3BInnes%2C+K+E%3BRoberts%2C+J+M%3BHoover%2C+R+N&rft.aulast=Troisi&rft.aufirst=R&rft.date=2007-08-28&rft.volume=97&rft.issue=5&rft.spage=688&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6603921 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Gender; Breast cancer; Cancer; Infants; offspring; Pregnancy DO - http://dx.doi.org/10.1038/sj.bjc.6603921 ER - TY - CPAPER T1 - Number of Axillary Lymph Nodes Dissected is not Affected after Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer T2 - 42nd World Congress of Surgery of the International Society of Surgery ISS/SIC (International Surgical Week) (ISW 2007) AN - 39394739; 4622693 JF - 42nd World Congress of Surgery of the International Society of Surgery ISS/SIC (International Surgical Week) (ISW 2007) AU - Youssef, O AU - Mohamed, A G AU - Anwar, H AU - Gouda, I AU - Mansour, O AU - Hamimi, W Y1 - 2007/08/26/ PY - 2007 DA - 2007 Aug 26 KW - Chemotherapy KW - Lymph nodes KW - Breast cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39394739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=42nd+World+Congress+of+Surgery+of+the+International+Society+of+Surgery+ISS%2FSIC+%28International+Surgical+Week%29+%28ISW+2007%29&rft.atitle=Number+of+Axillary+Lymph+Nodes+Dissected+is+not+Affected+after+Neoadjuvant+Chemotherapy+for+Locally+Advanced+Breast+Cancer&rft.au=Youssef%2C+O%3BMohamed%2C+A+G%3BAnwar%2C+H%3BGouda%2C+I%3BMansour%2C+O%3BHamimi%2C+W&rft.aulast=Youssef&rft.aufirst=O&rft.date=2007-08-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=42nd+World+Congress+of+Surgery+of+the+International+Society+of+Surgery+ISS%2FSIC+%28International+Surgical+Week%29+%28ISW+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isw2007.com/Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Breast Cancer in Young Women (35 Years or Younger): Features of Disease Presentation in a Developing Country T2 - 42nd World Congress of Surgery of the International Society of Surgery ISS/SIC (International Surgical Week) (ISW 2007) AN - 39357834; 4622694 JF - 42nd World Congress of Surgery of the International Society of Surgery ISS/SIC (International Surgical Week) (ISW 2007) AU - Youssef, O AU - Hassan, N AU - Nouh, A Y1 - 2007/08/26/ PY - 2007 DA - 2007 Aug 26 KW - Breast cancer KW - Developing countries KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39357834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=42nd+World+Congress+of+Surgery+of+the+International+Society+of+Surgery+ISS%2FSIC+%28International+Surgical+Week%29+%28ISW+2007%29&rft.atitle=Breast+Cancer+in+Young+Women+%2835+Years+or+Younger%29%3A+Features+of+Disease+Presentation+in+a+Developing+Country&rft.au=Youssef%2C+O%3BHassan%2C+N%3BNouh%2C+A&rft.aulast=Youssef&rft.aufirst=O&rft.date=2007-08-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=42nd+World+Congress+of+Surgery+of+the+International+Society+of+Surgery+ISS%2FSIC+%28International+Surgical+Week%29+%28ISW+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.isw2007.com/Abstracts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Auditory Perception in Landau-Kleffner Syndrome T2 - 2007 International Congress of Pediatrics (ICP 2007) AN - 39546989; 4700525 JF - 2007 International Congress of Pediatrics (ICP 2007) AU - Kaga, Makiko AU - Inagaki, Masumi AU - Suzuki, Seiko Y1 - 2007/08/25/ PY - 2007 DA - 2007 Aug 25 KW - Perception KW - Auditory perception KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39546989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Congress+of+Pediatrics+%28ICP+2007%29&rft.atitle=Auditory+Perception+in+Landau-Kleffner+Syndrome&rft.au=Kaga%2C+Makiko%3BInagaki%2C+Masumi%3BSuzuki%2C+Seiko&rft.aulast=Kaga&rft.aufirst=Makiko&rft.date=2007-08-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Congress+of+Pediatrics+%28ICP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.icp2007.gr/final/total.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Insights in Neurogenesis and Neuroprotection in Parkinson's Disease T2 - 11th Congress of the European Federation of Neurological Societies (EFNS 2007) AN - 39543110; 4674144 JF - 11th Congress of the European Federation of Neurological Societies (EFNS 2007) AU - Isacson, Ole Y1 - 2007/08/25/ PY - 2007 DA - 2007 Aug 25 KW - Neurogenesis KW - Neuroprotection KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39543110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Biology+%26+Drug+Design&rft.atitle=Natural+Products+Active+in+Aberrant+c-Kit+Signaling&rft.au=Henrich%2C+Curtis+J%3BGoncharova%2C+Ekaterina+I%3BWilson%2C+Jennifer+A%3BGardella%2C+Roberta+S%3BJohnson%2C+Tanya+R%3BMcMahon%2C+James+B%3BTakada%2C+Kentaro%3BBokesch%2C+Heidi+R%3BGustafson%2C+Kirk+R&rft.aulast=Henrich&rft.aufirst=Curtis&rft.date=2007-05-01&rft.volume=69&rft.issue=5&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Chemical+Biology+%26+Drug+Design&rft.issn=17470277&rft_id=info:doi/10.1111%2Fj.1747-0285.2007.00508.x L2 - http://www.kenes.com/efns2007/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Modeling Tissue Morphogenesis and Cancer in 3D AN - 20333294; 7553019 AB - Three-dimensional (3D) in vitro models span the gap between two-dimensional cell cultures and whole-animal systems. By mimicking features of the in vivo environment and taking advantage of the same tools used to study cells in traditional cell culture, 3D models provide unique perspectives on the behavior of stem cells, developing tissues and organs, and tumors. These models may help to accelerate translational research in cancer biology and tissue engineering. JF - Cell AU - Yamada, K M AU - Cukierman, E AD - National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, kenneth.yamada@nih.gov Y1 - 2007/08/24/ PY - 2007 DA - 2007 Aug 24 SP - 601 EP - 610 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 130 IS - 4 SN - 0092-8674, 0092-8674 KW - Biotechnology and Bioengineering Abstracts KW - Mimicry KW - Translation KW - Stem cells KW - Morphogenesis KW - Cell culture KW - Tumors KW - Tissue engineering KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20333294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell&rft.atitle=Modeling+Tissue+Morphogenesis+and+Cancer+in+3D&rft.au=Yamada%2C+K+M%3BCukierman%2C+E&rft.aulast=Yamada&rft.aufirst=K&rft.date=2007-08-24&rft.volume=130&rft.issue=4&rft.spage=601&rft.isbn=&rft.btitle=&rft.title=Cell&rft.issn=00928674&rft_id=info:doi/10.1016%2Fj.cell.2007.08.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cell culture; Cancer; Translation; Tumors; Tissue engineering; Stem cells; Mimicry; Morphogenesis DO - http://dx.doi.org/10.1016/j.cell.2007.08.006 ER - TY - JOUR T1 - Heterocyclic analogues of N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)arylcarboxamides with functionalized linking chains as novel dopamine D3 receptor ligands: potential substance abuse therapeutic agents. AN - 68167568; 17672446 AB - Dopamine D3 receptor antagonists and partial agonists have been shown to modulate drug-seeking effects induced by cocaine and other abused substances. Compound 6 [PG01037, (N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)-trans-but-2-enyl)-4-pyridine-2-ylbenzamide)] and related analogues are currently being evaluated in animal models of drug addiction. In these studies, a discrepancy between in vitro binding affinity, in vivo occupancy, and behavioral potency has been observed. The purpose of this study was to examine (1) modifications of the 2-pyridylphenyl moiety of 6 and (2) hydroxyl, acetyl, and cyclopropyl substitutions on the butylamide linking chain systematically coupled with 2-fluorenylamide or 2-pyridylphenylamide and 2-methoxy- or 2,3-dichloro-substituted phenylpiperazines to measure the impact on binding affinity, D2/D3 selectivity, lipophilicity, and function. In general, these modifications were well tolerated at the human dopamine D3 (hD3) receptor (Ki = 1-5 nM) as measured in competition binding assays. Several analogues showed >100-fold selectivity for dopamine D3 over D2 and D4 receptors. In addition, while all the derivatives with an olefinic linker were antagonists, in quinpirole-stimulated mitogenesis at hD3 receptors, several of the hydroxybutyl-linked analogues (16, 17, 21) showed partial agonist activity. Finally, several structural modifications reduced lipophilicities while retaining the desired binding profile. JF - Journal of medicinal chemistry AU - Grundt, Peter AU - Prevatt, Katherine M AU - Cao, Jianjing AU - Taylor, Michelle AU - Floresca, Christina Z AU - Choi, Ji-Kyung AU - Jenkins, Bruce G AU - Luedtke, Robert R AU - Newman, Amy Hauck AD - Medicinal Chemistry Section, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA. Y1 - 2007/08/23/ PY - 2007 DA - 2007 Aug 23 SP - 4135 EP - 4146 VL - 50 IS - 17 SN - 0022-2623, 0022-2623 KW - Amides KW - 0 KW - Benzamides KW - Ligands KW - N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)but-2-enyl)-4-pyridine-2-ylbenzamide KW - Piperazines KW - Pyridines KW - Receptors, Dopamine D3 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Animals KW - Benzamides -- chemistry KW - Stereoisomerism KW - Pyridines -- chemistry KW - Benzamides -- pharmacokinetics KW - Humans KW - Pyridines -- pharmacokinetics KW - Brain -- metabolism KW - Radioligand Assay KW - Structure-Activity Relationship KW - Rats KW - Binding, Competitive KW - Mitosis -- drug effects KW - Cell Line KW - Receptors, Dopamine D3 -- agonists KW - Piperazines -- chemical synthesis KW - Piperazines -- chemistry KW - Amides -- pharmacology KW - Amides -- chemical synthesis KW - Receptors, Dopamine D3 -- antagonists & inhibitors KW - Substance-Related Disorders -- drug therapy KW - Piperazines -- pharmacology KW - Amides -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68167568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Heterocyclic+analogues+of+N-%284-%284-%282%2C3-dichlorophenyl%29piperazin-1-yl%29butyl%29arylcarboxamides+with+functionalized+linking+chains+as+novel+dopamine+D3+receptor+ligands%3A+potential+substance+abuse+therapeutic+agents.&rft.au=Grundt%2C+Peter%3BPrevatt%2C+Katherine+M%3BCao%2C+Jianjing%3BTaylor%2C+Michelle%3BFloresca%2C+Christina+Z%3BChoi%2C+Ji-Kyung%3BJenkins%2C+Bruce+G%3BLuedtke%2C+Robert+R%3BNewman%2C+Amy+Hauck&rft.aulast=Grundt&rft.aufirst=Peter&rft.date=2007-08-23&rft.volume=50&rft.issue=17&rft.spage=4135&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=00222623&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-29 N1 - Date created - 2007-08-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Synthesis, Biological Activity, and Crystal Structure of Potent Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase That Retain Activity against Mutant Forms of the Enzyme AN - 19766392; 7581070 AB - In an ongoing effort to develop novel and potent nonnucleoside HIV-1 reverse transcriptase (RT) inhibitors that are effective against the wild type (WT) virus and clinically observed mutants, 1,2-bis-substituted benzimidazoles were synthesized and tested. Optimization of the N1 and C2 positions of benzimidazole led to the development of -(2,6-difluorobenzyl)-2-(2,6-difluorophenyl)-4-methylbenzimidazole (1) (IC sub(50) = 0.2 mu M, EC sub(50) = 0.44 mu M, and TC sub(50) greater than or equal to 100 against WT). This paper describes how substitution on the benzimidazole ring profoundly affects activity. Substituents at the benzimidazole C4 dramatically enhanced potency, while at C5 or C6 substituents were generally detrimental or neutral to activity, respectively. A 7-methyl analogue did not inhibit HIV-1 RT. Determination of the crystal structure of 1 bound to RT provided the basis for accurate modeling of additional analogues, which were synthesized and tested. Several derivatives were nanomolar inhibitors of wild-type virus and were effective against clinically relevant HIV-1 mutants. JF - Journal of Medicinal Chemistry AU - Morningstar, M L AU - Roth, T AU - Farnsworth, D W AU - Smith, M K AU - Watson, K AU - Buckheit, RW Jr AU - Das, K AU - Zhang, W AU - Arnold, E AU - Julias, J G AU - Hughes, SH AU - Michejda, C J AD - Molecular Aspects of Drug Design Section and Retroviral Replication Laboratory, National Cancer Institute-Frederick, P.O. Box B, Frederick, Maryland 21702, USA Y1 - 2007/08/23/ PY - 2007 DA - 2007 Aug 23 SP - 4003 EP - 4015 VL - 50 IS - 17 SN - 0022-2623, 0022-2623 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Human immunodeficiency virus 1 KW - Crystal structure KW - RNA-directed DNA polymerase KW - Enzymes KW - Benzimidazole KW - V 22360:AIDS and HIV KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19766392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medicinal+Chemistry&rft.atitle=Synthesis%2C+Biological+Activity%2C+and+Crystal+Structure+of+Potent+Nonnucleoside+Inhibitors+of+HIV-1+Reverse+Transcriptase+That+Retain+Activity+against+Mutant+Forms+of+the+Enzyme&rft.au=Morningstar%2C+M+L%3BRoth%2C+T%3BFarnsworth%2C+D+W%3BSmith%2C+M+K%3BWatson%2C+K%3BBuckheit%2C+RW+Jr%3BDas%2C+K%3BZhang%2C+W%3BArnold%2C+E%3BJulias%2C+J+G%3BHughes%2C+SH%3BMichejda%2C+C+J&rft.aulast=Morningstar&rft.aufirst=M&rft.date=2007-08-23&rft.volume=50&rft.issue=17&rft.spage=4003&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medicinal+Chemistry&rft.issn=00222623&rft_id=info:doi/10.1021%2Fjm060103d LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Crystal structure; Enzymes; RNA-directed DNA polymerase; Benzimidazole; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1021/jm060103d ER - TY - CPAPER T1 - Fostering International Validation and Acceptance of New and Alternative Methods: ICCVAM and NICEATM Initiatives T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39722781; 4721579 DE: JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Stokes, William Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39722781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Fostering+International+Validation+and+Acceptance+of+New+and+Alternative+Methods%3A+ICCVAM+and+NICEATM+Initiatives&rft.au=Stokes%2C+William&rft.aulast=Stokes&rft.aufirst=William&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Application of the Flow Cytometric Cytotoxicity Assay for Monitoring Cancer Vaccine Trials T2 - 13th International Congress of Immunology (ICI 2007) AN - 39692567; 4702463 JF - 13th International Congress of Immunology (ICI 2007) AU - Malyguine, A AU - Zaritskaya, L AU - Shafer-Weaver, K AU - Strobl, S AU - Gregory, M AU - Baseler, M Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Cancer KW - Vaccines KW - Cytotoxicity KW - Flow cytometry KW - Cancer vaccines KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39692567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Application+of+the+Flow+Cytometric+Cytotoxicity+Assay+for+Monitoring+Cancer+Vaccine+Trials&rft.au=Malyguine%2C+A%3BZaritskaya%2C+L%3BShafer-Weaver%2C+K%3BStrobl%2C+S%3BGregory%2C+M%3BBaseler%2C+M&rft.aulast=Malyguine&rft.aufirst=A&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Alternatives for Ocular Toxicity Testing: ICCVAM and NICEATM Recent and Planned Initiatives T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39626955; 4721459 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Stokes, William Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Toxicity testing KW - Bioaccumulation KW - Pollution indicators KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39626955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Alternatives+for+Ocular+Toxicity+Testing%3A+ICCVAM+and+NICEATM+Recent+and+Planned+Initiatives&rft.au=Stokes%2C+William&rft.aulast=Stokes&rft.aufirst=William&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Comet Assay: An Overview T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39624425; 4721511 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Tice, Raymond R Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Reviews KW - Comet assay KW - Toxicity testing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39624425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=The+Comet+Assay%3A+An+Overview&rft.au=Tice%2C+Raymond+R&rft.aulast=Tice&rft.aufirst=Raymond&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Topical Anesthetic Pre-treatment in the Draize Eye Test: Impact on Hazard Classification T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39605356; 4721648 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Stokes, William Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Eye KW - Classification KW - Anesthetics KW - Hazards KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39605356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Topical+Anesthetic+Pre-treatment+in+the+Draize+Eye+Test%3A+Impact+on+Hazard+Classification&rft.au=Stokes%2C+William&rft.aulast=Stokes&rft.aufirst=William&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Standardization of Protocols for the Validation of an In Vitro Estrogen Receptor Transcriptional Activation Assay T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39604754; 4721860 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Tice, Raymond Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Standardization KW - Estrogen receptors KW - Transcription activation KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39604754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Standardization+of+Protocols+for+the+Validation+of+an+In+Vitro+Estrogen+Receptor+Transcriptional+Activation+Assay&rft.au=Tice%2C+Raymond&rft.aulast=Tice&rft.aufirst=Raymond&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of B Cell Motility in Lymph Nodes T2 - 13th International Congress of Immunology (ICI 2007) AN - 39601280; 4701437 JF - 13th International Congress of Immunology (ICI 2007) AU - Kehrl, J H AU - Hwang, I AU - Park, C Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Lymph nodes KW - Lymphocytes B KW - Cell migration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39601280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Regulation+of+B+Cell+Motility+in+Lymph+Nodes&rft.au=Kehrl%2C+J+H%3BHwang%2C+I%3BPark%2C+C&rft.aulast=Kehrl&rft.aufirst=J&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vitro Cytotoxicity Test Methods for Estimating Rat Acute Oral Toxicity: Prediction of GHS Acute Oral Toxicity Categories T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39593849; 4721759 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Stokes, William Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Acute toxicity KW - Cytotoxicity KW - Toxicity testing KW - Bioaccumulation KW - Pollution indicators KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39593849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=In+Vitro+Cytotoxicity+Test+Methods+for+Estimating+Rat+Acute+Oral+Toxicity%3A+Prediction+of+GHS+Acute+Oral+Toxicity+Categories&rft.au=Stokes%2C+William&rft.aulast=Stokes&rft.aufirst=William&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Alternatives for Acute Oral Systemic Toxicity Testing: NICEATM/ICCVAM Current and Planned Activities T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39593454; 4721455 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Tice, Raymond Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Acute toxicity KW - Toxicity testing KW - Bioaccumulation KW - Pollution indicators KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39593454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Alternatives+for+Acute+Oral+Systemic+Toxicity+Testing%3A+NICEATM%2FICCVAM+Current+and+Planned+Activities&rft.au=Tice%2C+Raymond&rft.aulast=Tice&rft.aufirst=Raymond&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reducing Animal Use for Acute Oral Toxicity Testing: ICCVAM Recommendations for the Use of In Vitro Cytotoxicity Test Methods T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39584018; 4721691 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Stokes, William S Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Cytotoxicity KW - Acute toxicity KW - Toxicity testing KW - Bioaccumulation KW - Pollution indicators KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39584018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Reducing+Animal+Use+for+Acute+Oral+Toxicity+Testing%3A+ICCVAM+Recommendations+for+the+Use+of+In+Vitro+Cytotoxicity+Test+Methods&rft.au=Stokes%2C+William+S&rft.aulast=Stokes&rft.aufirst=William&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationship between Adverse Ocular Effects and their Reversibility T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39580666; 4721774 DE: JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Tice, Raymond Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39580666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Relationship+between+Adverse+Ocular+Effects+and+their+Reversibility&rft.au=Tice%2C+Raymond&rft.aulast=Tice&rft.aufirst=Raymond&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The NICEATM/ECVAM Validation Study of In Vitro Cytotoxicity Test Methods for Estimating Rat Acute Oral Toxicity T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39577955; 4721457 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Stokes, William Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Cytotoxicity KW - Acute toxicity KW - Toxicity testing KW - Bioaccumulation KW - Pollution indicators KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39577955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=The+NICEATM%2FECVAM+Validation+Study+of+In+Vitro+Cytotoxicity+Test+Methods+for+Estimating+Rat+Acute+Oral+Toxicity&rft.au=Stokes%2C+William&rft.aulast=Stokes&rft.aufirst=William&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Live Microfilariae of Brugia malayi Downregulate the Gene Expression and Function of TLR3 and TLR4 in Human DC Resulting in Inactivation of NFkB and Diminution of Inflammatory Cytokines T2 - 13th International Congress of Immunology (ICI 2007) AN - 39576256; 4701272 JF - 13th International Congress of Immunology (ICI 2007) AU - Semnani, R Tolouei AU - Goel, P AU - Leifer, C A AU - Mostbock, S AU - Sabzevari, H AU - Nutman, T B Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Inactivation KW - Toll-like receptors KW - TLR3 protein KW - Gene expression KW - TLR4 protein KW - Cytokines KW - NF-B protein KW - Inflammation KW - Brugia malayi KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39576256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Live+Microfilariae+of+Brugia+malayi+Downregulate+the+Gene+Expression+and+Function+of+TLR3+and+TLR4+in+Human+DC+Resulting+in+Inactivation+of+NFkB+and+Diminution+of+Inflammatory+Cytokines&rft.au=Semnani%2C+R+Tolouei%3BGoel%2C+P%3BLeifer%2C+C+A%3BMostbock%2C+S%3BSabzevari%2C+H%3BNutman%2C+T+B&rft.aulast=Semnani&rft.aufirst=R&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of c-Myc Expression by NFAT1 Transcription Factor in Lymphocytes T2 - 13th International Congress of Immunology (ICI 2007) AN - 39561905; 4702516 JF - 13th International Congress of Immunology (ICI 2007) AU - Mognol, G P AU - Caetano, M S AU - Robbs, B K AU - Viola, J P B Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Lymphocytes KW - C-Myc protein KW - Transcription factors KW - NF-AT1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39561905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Regulation+of+c-Myc+Expression+by+NFAT1+Transcription+Factor+in+Lymphocytes&rft.au=Mognol%2C+G+P%3BCaetano%2C+M+S%3BRobbs%2C+B+K%3BViola%2C+J+P+B&rft.aulast=Mognol&rft.aufirst=G&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Quality of the Th1 Response Following Vaccination Correlates with Protection Against Leishmania Major Infection T2 - 13th International Congress of Immunology (ICI 2007) AN - 39558110; 4701115 JF - 13th International Congress of Immunology (ICI 2007) AU - Darrah, P A AU - Patel, D T AU - De Luca, P M AU - Lindsay, R W B AU - Davey, D F AU - Roederer, M AU - Seder, R A Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Infection KW - Vaccination KW - Lymphocytes T KW - Helper cells KW - Leishmania major KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39558110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=The+Quality+of+the+Th1+Response+Following+Vaccination+Correlates+with+Protection+Against+Leishmania+Major+Infection&rft.au=Darrah%2C+P+A%3BPatel%2C+D+T%3BDe+Luca%2C+P+M%3BLindsay%2C+R+W+B%3BDavey%2C+D+F%3BRoederer%2C+M%3BSeder%2C+R+A&rft.aulast=Darrah&rft.aufirst=P&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel TTF-1 Mutation with Mild IgA Deficiency T2 - 13th International Congress of Immunology (ICI 2007) AN - 39556897; 4702517 JF - 13th International Congress of Immunology (ICI 2007) AU - Elloumi, H AU - Uzel, G AU - Ding, L AU - Anderson, V AU - Holland, S M Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Mutation KW - Immunoglobulin A KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39556897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Novel+TTF-1+Mutation+with+Mild+IgA+Deficiency&rft.au=Elloumi%2C+H%3BUzel%2C+G%3BDing%2C+L%3BAnderson%2C+V%3BHolland%2C+S+M&rft.aulast=Elloumi&rft.aufirst=H&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Estrogen Receptor Mechanisms: How They Influence Environmental Factor Activities T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39550633; 4721507 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Korach, Kenneth S Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Environmental factors KW - Estrogen receptors KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39550633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=Estrogen+Receptor+Mechanisms%3A+How+They+Influence+Environmental+Factor+Activities&rft.au=Korach%2C+Kenneth+S&rft.aulast=Korach&rft.aufirst=Kenneth&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distinct Roles of Two Types of NKT Cells in the Regulation of Tumor Imunity T2 - 13th International Congress of Immunology (ICI 2007) AN - 39547395; 4702078 JF - 13th International Congress of Immunology (ICI 2007) AU - Terabe, M AU - Ambrosino, E AU - Takaku, S AU - Peng, J AU - Miyake, S AU - Halder, R C AU - Yamamura, T AU - Kumar, V AU - Berzofsky, J A Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Tumors KW - Lymphocytes T KW - Natural killer cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39547395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Distinct+Roles+of+Two+Types+of+NKT+Cells+in+the+Regulation+of+Tumor+Imunity&rft.au=Terabe%2C+M%3BAmbrosino%2C+E%3BTakaku%2C+S%3BPeng%2C+J%3BMiyake%2C+S%3BHalder%2C+R+C%3BYamamura%2C+T%3BKumar%2C+V%3BBerzofsky%2C+J+A&rft.aulast=Terabe&rft.aufirst=M&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NK Cells are Required for Optimal IL-12 Production by CD11b+CD8- Dendritic Cells and Host Resistance to Toxoplasma Gondii. T2 - 13th International Congress of Immunology (ICI 2007) AN - 39541277; 4701078 JF - 13th International Congress of Immunology (ICI 2007) AU - Goldszmid, R AU - Feng, C AU - Rothfuchs, A AU - Jankovic, D AU - Caspar, P AU - Reinhardt, L AU - Locksley, R AU - Sher, A Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - CD11b antigen KW - Dendritic cells KW - Interleukin 12 KW - Natural killer cells KW - Toxoplasma gondii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39541277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=NK+Cells+are+Required+for+Optimal+IL-12+Production+by+CD11b%2BCD8-+Dendritic+Cells+and+Host+Resistance+to+Toxoplasma+Gondii.&rft.au=Goldszmid%2C+R%3BFeng%2C+C%3BRothfuchs%2C+A%3BJankovic%2C+D%3BCaspar%2C+P%3BReinhardt%2C+L%3BLocksley%2C+R%3BSher%2C+A&rft.aulast=Goldszmid&rft.aufirst=R&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Redesigned NICEATM-ICCVAM Website: Improving Communication with Stakeholders T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39533166; 4721689 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Tice, Raymond Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Stakeholders KW - Communication KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39533166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=The+Redesigned+NICEATM-ICCVAM+Website%3A+Improving+Communication+with+Stakeholders&rft.au=Tice%2C+Raymond&rft.aulast=Tice&rft.aufirst=Raymond&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NICEATM/ECVAM/JaCVAM Multi-phased International Validation Study of an In Vitro Estrogen Receptor Transcriptional Activation Assay to Detect Agonist and Antagonist Activity T2 - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AN - 39531097; 4721861 JF - 6th World Congress on Alternatives Animal Use in the Life Sciences (WC6) AU - Stokes, William S Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Estrogen receptors KW - Transcription activation KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39531097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.atitle=NICEATM%2FECVAM%2FJaCVAM+Multi-phased+International+Validation+Study+of+an+In+Vitro+Estrogen+Receptor+Transcriptional+Activation+Assay+to+Detect+Agonist+and+Antagonist+Activity&rft.au=Stokes%2C+William+S&rft.aulast=Stokes&rft.aufirst=William&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Alternatives+Animal+Use+in+the+Life+Sciences+%28WC6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ech.co.jp/wc6/pdf/wc6_session.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of the Defective Interaction between a Subset of Natural Killer Cells and Dendritic Cells in HIV-1 Infection T2 - 13th International Congress of Immunology (ICI 2007) AN - 39530680; 4701059 JF - 13th International Congress of Immunology (ICI 2007) AU - Mavilio, D AU - Lombardo, G AU - Fogli, M AU - Kinter, A AU - La Sala, A AU - Follmann, D AU - Roby, G AU - Kovacs, C AU - Marcenaro, E AU - Pende, D AU - Moretta, A AU - Fauci, A S Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Infection KW - Dendritic cells KW - Natural killer cells KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39530680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Characterization+of+the+Defective+Interaction+between+a+Subset+of+Natural+Killer+Cells+and+Dendritic+Cells+in+HIV-1+Infection&rft.au=Mavilio%2C+D%3BLombardo%2C+G%3BFogli%2C+M%3BKinter%2C+A%3BLa+Sala%2C+A%3BFollmann%2C+D%3BRoby%2C+G%3BKovacs%2C+C%3BMarcenaro%2C+E%3BPende%2C+D%3BMoretta%2C+A%3BFauci%2C+A+S&rft.aulast=Mavilio&rft.aufirst=D&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CYBB, a NADPH-oxidase Coding Gene: Restricted Diversity in Humans and Evidence for Differential Long Term Purifying Selection on Trans-membrane and Cytosolic Domains T2 - 13th International Congress of Immunology (ICI 2007) AN - 39526793; 4701303 JF - 13th International Congress of Immunology (ICI 2007) AU - Tarazona-Santos, E M AU - Bernig, T AU - Burdett, L AU - Fabbri, C AU - Magalhaes, W AU - Redondo, R AU - Welch, R AU - Yeager, M AU - Chanock, S J Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - NADPH oxidase KW - Genetic diversity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39526793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=CYBB%2C+a+NADPH-oxidase+Coding+Gene%3A+Restricted+Diversity+in+Humans+and+Evidence+for+Differential+Long+Term+Purifying+Selection+on+Trans-membrane+and+Cytosolic+Domains&rft.au=Tarazona-Santos%2C+E+M%3BBernig%2C+T%3BBurdett%2C+L%3BFabbri%2C+C%3BMagalhaes%2C+W%3BRedondo%2C+R%3BWelch%2C+R%3BYeager%2C+M%3BChanock%2C+S+J&rft.aulast=Tarazona-Santos&rft.aufirst=E&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Gene Expression Profile between M. abscessus and M. avium: Possible Role of SOCS Proteins in Mediating the Extent of Innate Immune Response T2 - 13th International Congress of Immunology (ICI 2007) AN - 39523367; 4701167 JF - 13th International Congress of Immunology (ICI 2007) AU - Sampaio, E P Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Immune response KW - Gene expression KW - Immunity KW - Defense mechanisms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39523367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Differential+Gene+Expression+Profile+between+M.+abscessus+and+M.+avium%3A+Possible+Role+of+SOCS+Proteins+in+Mediating+the+Extent+of+Innate+Immune+Response&rft.au=Sampaio%2C+E+P&rft.aulast=Sampaio&rft.aufirst=E&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Histone Acetylation is Associated with Differential Gene Expression in the Rapid and Robust Memory CD8+ T Cell Response T2 - 13th International Congress of Immunology (ICI 2007) AN - 39522580; 4701266 JF - 13th International Congress of Immunology (ICI 2007) AU - Fann, M AU - Weng, N P Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Gene expression KW - Memory cells KW - Histones KW - CD8 antigen KW - Lymphocytes T KW - Immunological memory KW - Acetylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39522580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Histone+Acetylation+is+Associated+with+Differential+Gene+Expression+in+the+Rapid+and+Robust+Memory+CD8%2B+T+Cell+Response&rft.au=Fann%2C+M%3BWeng%2C+N+P&rft.aulast=Fann&rft.aufirst=M&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulatory Elements Governing Transcription of the Human DAP10 Gene T2 - 13th International Congress of Immunology (ICI 2007) AN - 39494426; 4700945 JF - 13th International Congress of Immunology (ICI 2007) AU - Coligan, J E AU - Marusina, A AU - Burgess, S J AU - Borrego, F Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Regulatory sequences KW - Transcription KW - DAP10 gene KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39494426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Regulatory+Elements+Governing+Transcription+of+the+Human+DAP10+Gene&rft.au=Coligan%2C+J+E%3BMarusina%2C+A%3BBurgess%2C+S+J%3BBorrego%2C+F&rft.aulast=Coligan&rft.aufirst=J&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Abrogation of Potent Humoral Vaccine Responses in Patients on Long-term Anti-CD25 Therapy T2 - 13th International Congress of Immunology (ICI 2007) AN - 39490339; 4701109 JF - 13th International Congress of Immunology (ICI 2007) AU - Ragheb, J A AU - Buggage, R AU - Reed, G AU - Levy-Clarke, G AU - Nussenblatt, R Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Vaccines KW - Therapy KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39490339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Abrogation+of+Potent+Humoral+Vaccine+Responses+in+Patients+on+Long-term+Anti-CD25+Therapy&rft.au=Ragheb%2C+J+A%3BBuggage%2C+R%3BReed%2C+G%3BLevy-Clarke%2C+G%3BNussenblatt%2C+R&rft.aulast=Ragheb&rft.aufirst=J&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Small Intestinal Lamina Propria Dendritic Cells Favor the Conversion of Foxp3 super(+) T sub(reg) T2 - 13th International Congress of Immunology (ICI 2007) AN - 39490046; 4701024 JF - 13th International Congress of Immunology (ICI 2007) AU - Sun, C AU - Hall, J AU - Blank, R AU - Belkaid, Y Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Intestine KW - Dendritic cells KW - Lymphocytes T KW - Lamina propria KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39490046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Small+Intestinal+Lamina+Propria+Dendritic+Cells+Favor+the+Conversion+of+Foxp3+super%28%2B%29+T+sub%28reg%29&rft.au=Sun%2C+C%3BHall%2C+J%3BBlank%2C+R%3BBelkaid%2C+Y&rft.aulast=Sun&rft.aufirst=C&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dual Role for NFAT Transcription Factors in Cell Proliferation and Transformation T2 - 13th International Congress of Immunology (ICI 2007) AN - 39452860; 4701125 JF - 13th International Congress of Immunology (ICI 2007) AU - Robbs, B K AU - Cruz, A L S AU - Mognol, G P AU - Viola, J P B Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Cell proliferation KW - Transcription factors KW - Transformation KW - NF-AT protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39452860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Dual+Role+for+NFAT+Transcription+Factors+in+Cell+Proliferation+and+Transformation&rft.au=Robbs%2C+B+K%3BCruz%2C+A+L+S%3BMognol%2C+G+P%3BViola%2C+J+P+B&rft.aulast=Robbs&rft.aufirst=B&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Filarial Parasites Induce NK Cell Activation, NK1 (IFNg and TNFa) and NK2 (IL-4 and IL-5) Differentiation and Subsequent Apoptotic Cell Death T2 - 13th International Congress of Immunology (ICI 2007) AN - 39452206; 4700965 JF - 13th International Congress of Immunology (ICI 2007) AU - Babu, S Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 KW - Parasites KW - Mortality KW - Tumor necrosis factor-a KW - Interleukin 5 KW - Cell death KW - Interleukin 4 KW - Differentiation KW - Natural killer cells KW - Cell activation KW - Apoptosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39452206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.atitle=Filarial+Parasites+Induce+NK+Cell+Activation%2C+NK1+%28IFNg+and+TNFa%29+and+NK2+%28IL-4+and+IL-5%29+Differentiation+and+Subsequent+Apoptotic+Cell+Death&rft.au=Babu%2C+S&rft.aulast=Babu&rft.aufirst=S&rft.date=2007-08-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Immunology+%28ICI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunorio2007.org.br/posterOral.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Structural and Biochemical Analyses of Shikimate Dehydrogenase AroE from Aquifex aeolicus: Implications for the Catalytic Mechanism AN - 20460952; 7728741 AB - The shikimate biosynthetic pathway is essential to microorganisms, plants, and parasites but absent from mammals. Therefore, shikimate dehydrogenase (SD) and other enzymes in the pathway are attractive targets for developing nontoxic antimicrobial agents, herbicides, and antiparasite drugs. SD catalyzes the fourth reaction in the pathway, the nicotinamide adenine dinucleotide phosphate- (NADP-) dependent reduction of 3-dehydroshikimic acid to shikimic acid (SA), as well as its reverse, by the transfer of a hydride. Previous structural studies reveal that the enzyme exists in two major conformations, an open and a closed form. For the reaction to occur, it is believed that the catalytic complex assumes the closed conformation. Nonetheless, the only structure containing both SA and NADP super(+) exhibits an open conformation (PDB entry 2EV9). Here, we present two crystal structures of Aquifex aeolicus SD, including a ternary complex with both SA and NADP super(+), which assumes the closed conformation and therefore contains a catalytically competent active site. On the basis of preexisting and novel structural and biochemical data, a catalytic mechanism is proposed. JF - Biochemistry (Washington) AU - Gan, J AU - Wu, Y AU - Prabakaran, P AU - Gu, Y AU - Li, Y AU - Andrykovitch, M AU - Liu, H AU - Gong, Y AU - Yan, H AU - Ji, X AD - Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 SP - 9513 EP - 9522 VL - 46 IS - 33 SN - 0006-2960, 0006-2960 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology KW - Parasites KW - shikimic acid KW - Data processing KW - Enzymes KW - Biochemical analysis KW - Animal physiology KW - Herbicides KW - Antimicrobial agents KW - Shikimate dehydrogenase KW - Aquifex aeolicus KW - Crystal structure KW - Microorganisms KW - Drugs KW - Dehydrogenases KW - Conformation KW - A 01340:Antibiotics & Antimicrobials KW - Q1 08246:Physiology, biochemistry, biophysics KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20460952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Structural+and+Biochemical+Analyses+of+Shikimate+Dehydrogenase+AroE+from+Aquifex+aeolicus%3A+Implications+for+the+Catalytic+Mechanism&rft.au=Gan%2C+J%3BWu%2C+Y%3BPrabakaran%2C+P%3BGu%2C+Y%3BLi%2C+Y%3BAndrykovitch%2C+M%3BLiu%2C+H%3BGong%2C+Y%3BYan%2C+H%3BJi%2C+X&rft.aulast=Gan&rft.aufirst=J&rft.date=2007-08-21&rft.volume=46&rft.issue=33&rft.spage=9513&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi602601e LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Microorganisms; Biochemical analysis; Herbicides; Animal physiology; Dehydrogenases; Shikimate dehydrogenase; Parasites; Data processing; shikimic acid; Crystal structure; Enzymes; Drugs; Antimicrobial agents; Conformation; Aquifex aeolicus DO - http://dx.doi.org/10.1021/bi602601e ER - TY - JOUR T1 - Inactivation of cytosolic aldehyde dehydrogenase via S-nitrosylation in ethanol-exposed rat liver AN - 19466331; 7552783 AB - Aldehyde dehydrogenase (ALDH) isozymes are critically important in the metabolism of acetaldehyde, thus preventing its accumulation after ethanol-exposure. We previously reported that mitochondrial ALDH2 could be inactivated via S-nitrosylation in ethanol-exposed rats. This study was aimed at investigating whether cytosolic ALDH1, with a relatively-low-K sub(m) value (11-18 mu M) for acetaldehyde, could be also inhibited in ethanol-exposed rats. Chronic or binge ethanol-exposure significantly decreased ALDH1 activity, which was restored by addition of dithiothreitol. Immunoblot analysis with the anti-S-nitroso-Cys antibody showed one immunoreactive band in the immunoprecipitated ALDH1 only from ethanol-exposed rats, but not from pair-fed controls, suggesting S-nitrosylation of ALDH1. Therefore inactivation of ALDH1 via S-nitrosylation can result in accumulation of acetaldehyde upon ethanol-exposure. JF - FEBS Letters AU - Moon, KH AU - Abdelmegeed, MA AU - Song, B J AD - National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 9000 Rockville pike, Bethesda, MD 20892-9410, USA, bjs@mail.nih.gov Y1 - 2007/08/21/ PY - 2007 DA - 2007 Aug 21 SP - 3967 EP - 3972 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 581 IS - 21 SN - 0014-5793, 0014-5793 KW - Toxicology Abstracts KW - Antibodies KW - Acetaldehyde KW - Isoenzymes KW - Liver KW - Mitochondria KW - Dithiothreitol KW - Aldehyde dehydrogenase KW - Metabolism KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19466331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=Inactivation+of+cytosolic+aldehyde+dehydrogenase+via+S-nitrosylation+in+ethanol-exposed+rat+liver&rft.au=Moon%2C+KH%3BAbdelmegeed%2C+MA%3BSong%2C+B+J&rft.aulast=Moon&rft.aufirst=KH&rft.date=2007-08-21&rft.volume=581&rft.issue=21&rft.spage=3967&rft.isbn=&rft.btitle=&rft.title=FEBS+Letters&rft.issn=00145793&rft_id=info:doi/10.1016%2Fj.febslet.2007.07.037 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Antibodies; Acetaldehyde; Liver; Isoenzymes; Mitochondria; Dithiothreitol; Aldehyde dehydrogenase; Metabolism DO - http://dx.doi.org/10.1016/j.febslet.2007.07.037 ER - TY - JOUR T1 - A turning point for conflicts of interest: the controversy over the National Academy of Sciences' first conflicts of interest disclosure policy. AN - 68180581; 17704427 AB - Conflicts of interest policies have become a part of the fabric of the conduct of biomedical research, yet such concerns are relatively recent history. Until the 1960s, concerns about conflicts of interest were confined to scientists who served as government advisors and contractors. However, in the 1970s, as a range of environmental and consumer safety issues gained public attention, the conclusions of researchers frequently came under attack because of concerns about experts' financial ties to private industry. These debates typically focused on evaluating potential carcinogens in the environment. In response, the National Academy of Sciences (NAS) developed its first conflict of interest policy, requiring committee members to disclose any "potential sources of bias" that "others might deem prejudicial." Scientists universally opposed the policy, however, for a range of reasons--while some argued that all experienced and knowledgeable experts were inherently conflicted, others were offended at the suggestion that any expert could be biased. Despite the controversy, the disclosure policy remained in place and became a model for subsequent professional and institutional policies in the biomedical sciences. However, although disclosure policies have become standard at academic medical centers and for publications in scientific journals, clinical researchers have continued to debate the content of these policies and the need for additional protections beyond disclosure. In the absence of a definitive standard, this historical case study can substantially inform ongoing discussion on conflicts of interest in clinical research. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Parascandola, Mark AD - Tobacco Control Research Branch, National Cancer Institute, Bethesda, MD 20892, USA. paramark@mail.nih.gov Y1 - 2007/08/20/ PY - 2007 DA - 2007 Aug 20 SP - 3774 EP - 3779 VL - 25 IS - 24 KW - Index Medicus KW - United States KW - Financing, Government KW - Research Support as Topic KW - Industry KW - Biomedical Research KW - Organizational Policy KW - Conflict of Interest KW - National Academy of Sciences (U.S.) KW - Disclosure -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68180581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=A+turning+point+for+conflicts+of+interest%3A+the+controversy+over+the+National+Academy+of+Sciences%27+first+conflicts+of+interest+disclosure+policy.&rft.au=Parascandola%2C+Mark&rft.aulast=Parascandola&rft.aufirst=Mark&rft.date=2007-08-20&rft.volume=25&rft.issue=24&rft.spage=3774&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-12 N1 - Date created - 2007-08-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Synthesis of a Reactive Linker for the Construction of Antibody-Drug Hybrid Molecules T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39461707; 4637892 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Thomas, Joshua D AU - Hofer, Thomas AU - Rader, Christoph AU - Burke Jr, Terrence R Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Hybrids KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39461707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Synthesis+of+a+Reactive+Linker+for+the+Construction+of+Antibody-Drug+Hybrid+Molecules&rft.au=Thomas%2C+Joshua+D%3BHofer%2C+Thomas%3BRader%2C+Christoph%3BBurke+Jr%2C+Terrence+R&rft.aulast=Thomas&rft.aufirst=Joshua&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Medicinal Chemistry in Drug Abuse Research T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39457210; 4637989 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Rice, Kenner C Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Drug abuse KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39457210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Medicinal+Chemistry+in+Drug+Abuse+Research&rft.au=Rice%2C+Kenner+C&rft.aulast=Rice&rft.aufirst=Kenner&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Design and Synthesis of C-Met Kinase Inhibitors Based on an in Silico Screen-Derived Lead T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39454490; 4638130 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Kim, Sung-Eun AU - Shi, Zhen-Dan AU - Peach, Megan AU - Giubellino, Alessio AU - Nicklaus, Marc C AU - Bottaro, Donald AU - Burke Jr, Terrence R Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Lead KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39454490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Design+and+Synthesis+of+C-Met+Kinase+Inhibitors+Based+on+an+in+Silico+Screen-Derived+Lead&rft.au=Kim%2C+Sung-Eun%3BShi%2C+Zhen-Dan%3BPeach%2C+Megan%3BGiubellino%2C+Alessio%3BNicklaus%2C+Marc+C%3BBottaro%2C+Donald%3BBurke+Jr%2C+Terrence+R&rft.aulast=Kim&rft.aufirst=Sung-Eun&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single Molecule FRET Efficiency Distributions of Diffusing Molecules with Conformational Dynamics T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39453040; 4631516 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Szabo, Attila AU - Gopich, Irina Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Fluorescence resonance energy transfer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39453040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Single+Molecule+FRET+Efficiency+Distributions+of+Diffusing+Molecules+with+Conformational+Dynamics&rft.au=Szabo%2C+Attila%3BGopich%2C+Irina&rft.aulast=Szabo&rft.aufirst=Attila&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Large Ion Channels: Role of Interactions with Penetrating Molecules T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39452615; 4631412 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Bezrukov, Sergey M Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Channels KW - Ion channels KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39452615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Large+Ion+Channels%3A+Role+of+Interactions+with+Penetrating+Molecules&rft.au=Bezrukov%2C+Sergey+M&rft.aulast=Bezrukov&rft.aufirst=Sergey&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Coarse Master Equations for Peptide Folding Kinetics from Atomistic Molecular Simulations T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39446711; 4630534 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Buchete, Nicolae-Viorel AU - Hummer, Gerhard Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Kinetics KW - Simulation KW - Mathematical models KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39446711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Coarse+Master+Equations+for+Peptide+Folding+Kinetics+from+Atomistic+Molecular+Simulations&rft.au=Buchete%2C+Nicolae-Viorel%3BHummer%2C+Gerhard&rft.aulast=Buchete&rft.aufirst=Nicolae-Viorel&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PCDD/Fs Formation onto the Fly Ash Matrix from Metal-Mediated Catalysts T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39446656; 4637686 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Lin, Chieh AU - Wang, Ya-Hsin Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Catalysts KW - Fly ash KW - PCDD KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39446656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=PCDD%2FFs+Formation+onto+the+Fly+Ash+Matrix+from+Metal-Mediated+Catalysts&rft.au=Lin%2C+Chieh%3BWang%2C+Ya-Hsin&rft.aulast=Lin&rft.aufirst=Chieh&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - D-Galactose Receptor-Targeted In Vivo Spectral Fluorescence Molecular Imaging of Peritoneal Metastasis T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39446627; 4637299 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Kobayashi, Hisataka AU - Hama, Yukihiro AU - Gunn, Andrew J AU - Koyama, Yoshinori AU - Urano, Yasuteru AU - Choyke, Peter L Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Fluorescence KW - Imaging techniques KW - Peritoneum KW - D-Galactose KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39446627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=D-Galactose+Receptor-Targeted+In+Vivo+Spectral+Fluorescence+Molecular+Imaging+of+Peritoneal+Metastasis&rft.au=Kobayashi%2C+Hisataka%3BHama%2C+Yukihiro%3BGunn%2C+Andrew+J%3BKoyama%2C+Yoshinori%3BUrano%2C+Yasuteru%3BChoyke%2C+Peter+L&rft.aulast=Kobayashi&rft.aufirst=Hisataka&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hidden Folding Intermediates in Small Proteins: Implications for the Folding Energy Landscape, Cooperativity, and Evolution of Protein Structures T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39446012; 4637166 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Bai, Yawen Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Energy KW - Protein structure KW - Evolution KW - Cooperativity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39446012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Hidden+Folding+Intermediates+in+Small+Proteins%3A+Implications+for+the+Folding+Energy+Landscape%2C+Cooperativity%2C+and+Evolution+of+Protein+Structures&rft.au=Bai%2C+Yawen&rft.aulast=Bai&rft.aufirst=Yawen&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synthesis of DAG-Lactones Containing Heterocyclic Moieties: Small Focused Libraries in Search of C1-Specific Domain Interactions T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39443404; 4638163 DE: JF - 234th National Meeting and Exposition of the American Chemical Society AU - El Kazzouli, Said AU - Lewin, Nancy E AU - Blumberg, Peter M AU - Marquez, Vicror E Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39443404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Synthesis+of+DAG-Lactones+Containing+Heterocyclic+Moieties%3A+Small+Focused+Libraries+in+Search+of+C1-Specific+Domain+Interactions&rft.au=El+Kazzouli%2C+Said%3BLewin%2C+Nancy+E%3BBlumberg%2C+Peter+M%3BMarquez%2C+Vicror+E&rft.aulast=El+Kazzouli&rft.aufirst=Said&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nitric Oxide-Induced Deamidation Retards and Reverses Fibril Formation by an Oligo(Glutamine/Asparagine) Peptide T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39438862; 4635270 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Kong, Li AU - Saavedra, Joseph E AU - Nagashima, kunio AU - Zheng, Jiwen AU - Patri, Anil AU - Keefer, Larry K Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Fibrillogenesis KW - Asparagine KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39438862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Nitric+Oxide-Induced+Deamidation+Retards+and+Reverses+Fibril+Formation+by+an+Oligo%28Glutamine%2FAsparagine%29+Peptide&rft.au=Kong%2C+Li%3BSaavedra%2C+Joseph+E%3BNagashima%2C+kunio%3BZheng%2C+Jiwen%3BPatri%2C+Anil%3BKeefer%2C+Larry+K&rft.aulast=Kong&rft.aufirst=Li&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Address Book for Chemical Space: The Chemical Structure Lookup Service (CSLS) T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39438359; 4630013 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Sitzmann, Markus AU - Filippov, Igor V AU - Ihlenfeldt, Wolf-Dietrich AU - Nicklaus, Marc C Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Books KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39438359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=An+Address+Book+for+Chemical+Space%3A+The+Chemical+Structure+Lookup+Service+%28CSLS%29&rft.au=Sitzmann%2C+Markus%3BFilippov%2C+Igor+V%3BIhlenfeldt%2C+Wolf-Dietrich%3BNicklaus%2C+Marc+C&rft.aulast=Sitzmann&rft.aufirst=Markus&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Carbocyclic Analogs of 1,3-Diazepin-2-One Nucleosides as Transition-State Inhibitors of Cytidine Deaminase T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39437100; 4634107 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Marquez, Victor E AU - Ludek, Olaf R Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Nucleoside analogs KW - Cytidine deaminase KW - Analogs KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39437100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Carbocyclic+Analogs+of+1%2C3-Diazepin-2-One+Nucleosides+as+Transition-State+Inhibitors+of+Cytidine+Deaminase&rft.au=Marquez%2C+Victor+E%3BLudek%2C+Olaf+R&rft.aulast=Marquez&rft.aufirst=Victor&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biomechanical Properties of Tissue Engineered Cartilage T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39435940; 4637521 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Horkay, Ferenc AU - Lin, David C AU - Horkayne-Szakaly, Iren AU - Dimitriadis, Emilios K AU - Silva, Candida AU - Basser, Peter J Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Biomechanics KW - Mechanical properties KW - Cartilage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39435940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Biomechanical+Properties+of+Tissue+Engineered+Cartilage&rft.au=Horkay%2C+Ferenc%3BLin%2C+David+C%3BHorkayne-Szakaly%2C+Iren%3BDimitriadis%2C+Emilios+K%3BSilva%2C+Candida%3BBasser%2C+Peter+J&rft.aulast=Horkay&rft.aufirst=Ferenc&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Discovery of Novel HIV-1 Integrase Inhibitors by Pharmacophore Search T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39435454; 4637877 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Weidlich, Iwona E AU - Marchand, Christophe AU - Pommier, Yves AU - Nicklaus, Marc C Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Integrase KW - Pharmacophores KW - Inhibitors KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39435454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Discovery+of+Novel+HIV-1+Integrase+Inhibitors+by+Pharmacophore+Search&rft.au=Weidlich%2C+Iwona+E%3BMarchand%2C+Christophe%3BPommier%2C+Yves%3BNicklaus%2C+Marc+C&rft.aulast=Weidlich&rft.aufirst=Iwona&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Study of Conformationally Biased Oligodeoxyribonucleotides Designed to Induce Bending And/Or Novel Secondary Structures in DNA T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39435268; 4638112 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Saneyoshi, Hisao AU - Marquez, Victor E Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Oligonucleotides KW - Protein structure KW - Secondary structure KW - Deformation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39435268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Study+of+Conformationally+Biased+Oligodeoxyribonucleotides+Designed+to+Induce+Bending+And%2FOr+Novel+Secondary+Structures+in+DNA&rft.au=Saneyoshi%2C+Hisao%3BMarquez%2C+Victor+E&rft.aulast=Saneyoshi&rft.aufirst=Hisao&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Dynamics Simulations Suggest a Way to Stabilize Von Hippel-Lindau Tumor Suppressor Protein and Rescue its Function T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39433673; 4630386 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Liu, Jin AU - Nussinov, Ruth Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Simulation KW - VHL protein KW - Tumor suppressor genes KW - Tumors KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39433673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Molecular+Dynamics+Simulations+Suggest+a+Way+to+Stabilize+Von+Hippel-Lindau+Tumor+Suppressor+Protein+and+Rescue+its+Function&rft.au=Liu%2C+Jin%3BNussinov%2C+Ruth&rft.aulast=Liu&rft.aufirst=Jin&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamics of Intramolecular Contact Formation in Islet Amyloid Polypeptide (IAPP) T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39430770; 4637175 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Vaiana, Sara AU - Eaton, William A AU - Ghirlando, Rodolfo AU - Hofrichter, James Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Amylin KW - Polypeptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39430770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Dynamics+of+Intramolecular+Contact+Formation+in+Islet+Amyloid+Polypeptide+%28IAPP%29&rft.au=Vaiana%2C+Sara%3BEaton%2C+William+A%3BGhirlando%2C+Rodolfo%3BHofrichter%2C+James&rft.aulast=Vaiana&rft.aufirst=Sara&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exploring QM/MM Paths for Mapping Reaction Mechanisms T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39427275; 4630440 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Woodcock III, H Lee AU - Hodoscek, Milan AU - Brooks, Bernard R Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Mapping KW - Reaction mechanisms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39427275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Exploring+QM%2FMM+Paths+for+Mapping+Reaction+Mechanisms&rft.au=Woodcock+III%2C+H+Lee%3BHodoscek%2C+Milan%3BBrooks%2C+Bernard+R&rft.aulast=Woodcock+III&rft.aufirst=H&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ultrafast Folding of the Villin Subdomain T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39425629; 4637168 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Cellmer, Troy AU - Eaton, William A AU - Hofrichter, James Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Protein folding KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39425629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Ultrafast+Folding+of+the+Villin+Subdomain&rft.au=Cellmer%2C+Troy%3BEaton%2C+William+A%3BHofrichter%2C+James&rft.aulast=Cellmer&rft.aufirst=Troy&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mutant Glycosyltransferases Assist in Linking Glycoconjugates Via Glycan Chains: Development of a Targeted Drug Delivery System and Contrast Agents for MRI T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39421252; 4637296 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Qasba, Pradman Krishen AU - Boeggeman, Elizabeth AU - Ramakrishnan, Boopathy Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Drug delivery KW - Mutants KW - Magnetic resonance imaging KW - Glycoconjugates KW - Glycosyltransferase KW - Contrast media KW - Polysaccharides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39421252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Mutant+Glycosyltransferases+Assist+in+Linking+Glycoconjugates+Via+Glycan+Chains%3A+Development+of+a+Targeted+Drug+Delivery+System+and+Contrast+Agents+for+MRI&rft.au=Qasba%2C+Pradman+Krishen%3BBoeggeman%2C+Elizabeth%3BRamakrishnan%2C+Boopathy&rft.aulast=Qasba&rft.aufirst=Pradman&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analytical Ultracentrifugation for the Characterization of Proteins and Protein Assemblies T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39417949; 4638495 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Schuck, Peter Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Ultracentrifugation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39417949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Analytical+Ultracentrifugation+for+the+Characterization+of+Proteins+and+Protein+Assemblies&rft.au=Schuck%2C+Peter&rft.aulast=Schuck&rft.aufirst=Peter&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Utilizing a Diazirine and Alkyne Containing Probe in a Proof of Principle Study to Investigate Small Molecule Interactions Across the Proteome T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39417908; 4638206 JF - 234th National Meeting and Exposition of the American Chemical Society AU - LeClair, Christopher A AU - Prinz, William A AU - Raychaudhuri, Sumana AU - Thomas, Craig J Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Alkynes KW - Probes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39417908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Utilizing+a+Diazirine+and+Alkyne+Containing+Probe+in+a+Proof+of+Principle+Study+to+Investigate+Small+Molecule+Interactions+Across+the+Proteome&rft.au=LeClair%2C+Christopher+A%3BPrinz%2C+William+A%3BRaychaudhuri%2C+Sumana%3BThomas%2C+Craig+J&rft.aulast=LeClair&rft.aufirst=Christopher&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Deducing the Multiple Binding Modes of p53 Tetramer DNA Interaction Based on Full-site Palindrome of p53 Response Elements T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39414611; 4630255 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Ma, Buyong AU - Levine, Arnold J Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - P53 protein KW - Regulatory sequences KW - Palindromes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39414611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Deducing+the+Multiple+Binding+Modes+of+p53+Tetramer+DNA+Interaction+Based+on+Full-site+Palindrome+of+p53+Response+Elements&rft.au=Ma%2C+Buyong%3BLevine%2C+Arnold+J&rft.aulast=Ma&rft.aufirst=Buyong&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Generalization of the Gaussian Electrostatic Model: A Molecular Density Based Force Field T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39408615; 4630132 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Cisneros, G Andres AU - Piquemal, Jean-Philip AU - Darden, Thomas A Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Molecular modelling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39408615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Generalization+of+the+Gaussian+Electrostatic+Model%3A+A+Molecular+Density+Based+Force+Field&rft.au=Cisneros%2C+G+Andres%3BPiquemal%2C+Jean-Philip%3BDarden%2C+Thomas+A&rft.aulast=Cisneros&rft.aufirst=G&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proton Transfer Along Ordered Water Chains Inside Carbon Nanotubes T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39408558; 4630432 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Hummer, Gerhard AU - Hassan, Sergio A AU - Lee, Yong S AU - Dellago, Christoph Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Nanotechnology KW - Carbon KW - Protons KW - Nanotubes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39408558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Proton+Transfer+Along+Ordered+Water+Chains+Inside+Carbon+Nanotubes&rft.au=Hummer%2C+Gerhard%3BHassan%2C+Sergio+A%3BLee%2C+Yong+S%3BDellago%2C+Christoph&rft.aulast=Hummer&rft.aufirst=Gerhard&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Simulation of Interfacial Systems with Isotropic Periodical Sum T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39395100; 4630103 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Wu, Xiongwu AU - Klauda, Jeffery B AU - Pastor, Richard W AU - Brooks, Bernard R Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Simulation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39395100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Simulation+of+Interfacial+Systems+with+Isotropic+Periodical+Sum&rft.au=Wu%2C+Xiongwu%3BKlauda%2C+Jeffery+B%3BPastor%2C+Richard+W%3BBrooks%2C+Bernard+R&rft.aulast=Wu&rft.aufirst=Xiongwu&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phthalimide-Containing Hydrazides and Amides as Diketo Acid-Class HIV-1 Integrase Inhibitors T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39393775; 4637875 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Zhao, Xue Zhi AU - Semenova, Elena A AU - Vu, B Christie AU - Liao, Chenzhong AU - Nicklaus, Marc C AU - Hughes, Stephen H AU - Pommier, Yves AU - Burke Jr, Terrence R Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Amides KW - Integrase KW - Inhibitors KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39393775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Phthalimide-Containing+Hydrazides+and+Amides+as+Diketo+Acid-Class+HIV-1+Integrase+Inhibitors&rft.au=Zhao%2C+Xue+Zhi%3BSemenova%2C+Elena+A%3BVu%2C+B+Christie%3BLiao%2C+Chenzhong%3BNicklaus%2C+Marc+C%3BHughes%2C+Stephen+H%3BPommier%2C+Yves%3BBurke+Jr%2C+Terrence+R&rft.aulast=Zhao&rft.aufirst=Xue&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NIH Programs in Single Molecule Biophysics, Cellular Imaging and Nanoscience T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39389052; 4631505 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Lewis, Catherine Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Biophysics KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39389052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=NIH+Programs+in+Single+Molecule+Biophysics%2C+Cellular+Imaging+and+Nanoscience&rft.au=Lewis%2C+Catherine&rft.aulast=Lewis&rft.aufirst=Catherine&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Virtual Screening of the Inhibitors into Tyrosyl-DNA Phoshodiesterase (Tdp1) Active Sites T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39387339; 4637956 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Weidlich, Iwona E AU - Dexheimer, Thomas AU - Pommier, Yves AU - Merchand, Christophe AU - Nicklaus, Marc C Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Screening KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39387339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Virtual+Screening+of+the+Inhibitors+into+Tyrosyl-DNA+Phoshodiesterase+%28Tdp1%29+Active+Sites&rft.au=Weidlich%2C+Iwona+E%3BDexheimer%2C+Thomas%3BPommier%2C+Yves%3BMerchand%2C+Christophe%3BNicklaus%2C+Marc+C&rft.aulast=Weidlich&rft.aufirst=Iwona&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Solid-Liquid Multiphase Simulation in CHARMM with Simultaneous use of Class-I and Class-II Force Fields: Application to Peptide Adsorptions on Polymer Surfaces T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39385326; 4636472 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Biswas, Pradip Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Adsorption KW - Simulation KW - Polymers KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39385326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Solid-Liquid+Multiphase+Simulation+in+CHARMM+with+Simultaneous+use+of+Class-I+and+Class-II+Force+Fields%3A+Application+to+Peptide+Adsorptions+on+Polymer+Surfaces&rft.au=Biswas%2C+Pradip&rft.aulast=Biswas&rft.aufirst=Pradip&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Addiction and Brain Mechanisms T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39383675; 4637985 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Hoffer, Barry Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Brain KW - Addiction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39383675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Addiction+and+Brain+Mechanisms&rft.au=Hoffer%2C+Barry&rft.aulast=Hoffer&rft.aufirst=Barry&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synthesis of Conformationally Locked Versions of Puromycin as Tools to Understand the Role of Furanose Conformation in the Peptidyl Transfer Reaction T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39373615; 4638200 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Saneyoshi, Hisao AU - Choi, Yongseok AU - Strazewski, Peter AU - Marquez, Victor E Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Conformation KW - Puromycin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39373615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Synthesis+of+Conformationally+Locked+Versions+of+Puromycin+as+Tools+to+Understand+the+Role+of+Furanose+Conformation+in+the+Peptidyl+Transfer+Reaction&rft.au=Saneyoshi%2C+Hisao%3BChoi%2C+Yongseok%3BStrazewski%2C+Peter%3BMarquez%2C+Victor+E&rft.aulast=Saneyoshi&rft.aufirst=Hisao&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Imaging Probe Development Center: An NIH Roadmap Initiative to Promote Molecular Imaging Applications in Interdisciplinary Research T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39358572; 4633886 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Li, Haitao AU - Kaur, G AU - Shi, Z AU - Sulima, A AU - Teng, B AU - Vasalatiy, O AU - Wu, H. AU - Xu, B. AU - Cofiell, S AU - Neale, N AU - Ruddy, B AU - Wilson, C AU - Griffiths, G L Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Interdisciplinary research KW - Imaging techniques KW - Probes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39358572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=The+Imaging+Probe+Development+Center%3A+An+NIH+Roadmap+Initiative+to+Promote+Molecular+Imaging+Applications+in+Interdisciplinary+Research&rft.au=Li%2C+Haitao%3BKaur%2C+G%3BShi%2C+Z%3BSulima%2C+A%3BTeng%2C+B%3BVasalatiy%2C+O%3BWu%2C+H.%3BXu%2C+B.%3BCofiell%2C+S%3BNeale%2C+N%3BRuddy%2C+B%3BWilson%2C+C%3BGriffiths%2C+G+L&rft.aulast=Li&rft.aufirst=Haitao&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Study of the Chlorophenols Combustion in a Laboratory Scale Spouted Bed Incinerator T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39357875; 4633536 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Lin, Chieh AU - Wang, Ya-Hsin Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Incinerators KW - Combustion KW - Chlorophenols KW - Incineration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39357875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Study+of+the+Chlorophenols+Combustion+in+a+Laboratory+Scale+Spouted+Bed+Incinerator&rft.au=Lin%2C+Chieh%3BWang%2C+Ya-Hsin&rft.aulast=Lin&rft.aufirst=Chieh&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Packed Column Sfc: A Fast Separation Technique for the Clinical Laboratory T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39353996; 4632337 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Issaq, Haleem J AU - Xu, X. AU - Roman, J M AU - Abbott, E AU - Veenstra, T D Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Separation techniques KW - Separation processes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39353996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Packed+Column+Sfc%3A+A+Fast+Separation+Technique+for+the+Clinical+Laboratory&rft.au=Issaq%2C+Haleem+J%3BXu%2C+X.%3BRoman%2C+J+M%3BAbbott%2C+E%3BVeenstra%2C+T+D&rft.aulast=Issaq&rft.aufirst=Haleem&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modeling Alzheimer Amyloid Conformations and Toxicity T2 - 234th National Meeting and Exposition of the American Chemical Society AN - 39325815; 4631361 JF - 234th National Meeting and Exposition of the American Chemical Society AU - Nussinov, Ruth AU - Jang, Hyunbum AU - Zheng, Jie AU - Ma, Buyong Y1 - 2007/08/19/ PY - 2007 DA - 2007 Aug 19 KW - Toxicity KW - Amyloid KW - Neurodegenerative diseases KW - Conformation KW - Alzheimer's disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39325815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.atitle=Modeling+Alzheimer+Amyloid+Conformations+and+Toxicity&rft.au=Nussinov%2C+Ruth%3BJang%2C+Hyunbum%3BZheng%2C+Jie%3BMa%2C+Buyong&rft.aulast=Nussinov&rft.aufirst=Ruth&rft.date=2007-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=234th+National+Meeting+and+Exposition+of+the+American+Chemical+Society&rft.issn=&rft_id=info:doi/ L2 - http://oasys2.confex.com/acs/234nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Targeted inhibition of glucuronidation markedly improves drug efficacy in mice-A model AN - 19728633; 7539064 AB - Finding UDP-glucuronosyltransferases (UGT) require protein kinase C-mediated phosphorylation is important information that allows manipulation of this critical system. UGTs glucuronidate numerous aromatic-like chemicals derived from metabolites, diet, environment and, inadvertently, therapeutics to reduce toxicities. As UGTs are inactivated by downregulating PKCs with reversibly-acting dietary curcumin, we determined the impact of gastro-intestinal glucuronidation on free-drug uptake and efficacy using immunosuppressant, mycophenolic acid (MPA), in mice. Expressed in COS-1 cells, mouse GI-distributed Ugt1a1 glucuronidates curcumin and MPA and undergoes irreversibly and reversibly dephosphorylation by PKC-specific inhibitor calphostin-C and general-kinase inhibitor curcumin, respectively, with parallel effects on activity. Moreover, oral curcumin-administration to mice reversibly inhibited glucuronidation in GI-tissues. Finally, successive oral administration of curcumin and MPA to antigen-treated mice increased serum free MPA and immunosuppression up to 9-fold. Results indicate targeted inhibition of GI glucuronidation in mice markedly improved free-chemical uptake and efficacy using MPA as a model. JF - Biochemical and Biophysical Research Communications AU - Basu, N K AU - Kole, L AU - Basu, M AU - McDonagh, A F AU - Owens, I S AD - National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 8D-42, Bethesda, MD 20892-1830, USA, basun@mail.nih.gov Y1 - 2007/08/17/ PY - 2007 DA - 2007 Aug 17 SP - 7 EP - 13 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 360 IS - 1 SN - 0006-291X, 0006-291X KW - Biotechnology and Bioengineering Abstracts KW - Diets KW - Protein kinase C KW - Curcumin KW - Mycophenolic acid KW - Dephosphorylation KW - UDP-glucuronosyltransferase KW - Oral administration KW - Metabolites KW - Toxicity KW - Immunosuppressive agents KW - Phosphorylation KW - Drugs KW - Immunosuppression KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19728633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Targeted+inhibition+of+glucuronidation+markedly+improves+drug+efficacy+in+mice-A+model&rft.au=Basu%2C+N+K%3BKole%2C+L%3BBasu%2C+M%3BMcDonagh%2C+A+F%3BOwens%2C+I+S&rft.aulast=Basu&rft.aufirst=N&rft.date=2007-08-17&rft.volume=360&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1016%2Fj.bbrc.2007.05.224 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Curcumin; Protein kinase C; Toxicity; Immunosuppressive agents; Diets; Oral administration; Dephosphorylation; Metabolites; UDP-glucuronosyltransferase; Mycophenolic acid; Phosphorylation; Drugs; Immunosuppression DO - http://dx.doi.org/10.1016/j.bbrc.2007.05.224 ER - TY - JOUR T1 - V-PROLI/NO, a prodrug of the nitric oxide donor, PROLI/NO. AN - 68151855; 17658755 AB - The sensitivity to decomposition of the nitric oxide (NO) donor ion, 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO), complicates direct electrophilic substitution to form useful prodrug derivatives. A modified general synthetic approach involving 1-[2-(hydroxymethyl)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate ion (structure A, above) was used to prepare several PROLI/NO prodrugs including the previously inaccessible O2-vinyl derivative, V-PROLI/NO. Metabolism of V-PROLI/NO by liver microsomes enriched in human cytochrome P450 isoforms was demonstrated. JF - Organic letters AU - Chakrapani, Harinath AU - Showalter, Brett M AU - Kong, Li AU - Keefer, Larry K AU - Saavedra, Joseph E AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. Y1 - 2007/08/16/ PY - 2007 DA - 2007 Aug 16 SP - 3409 EP - 3412 VL - 9 IS - 17 SN - 1523-7060, 1523-7060 KW - Nitric Oxide Donors KW - 0 KW - Prodrugs KW - Protein Isoforms KW - Vinyl Compounds KW - proline-nitric oxide KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Proline KW - 9DLQ4CIU6V KW - Index Medicus KW - Microsomes, Liver -- metabolism KW - Humans KW - Proline -- metabolism KW - Nitric Oxide Donors -- chemical synthesis KW - Prodrugs -- metabolism KW - Nitric Oxide Donors -- metabolism KW - Proline -- chemical synthesis KW - Proline -- analogs & derivatives KW - Prodrugs -- chemical synthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68151855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Organic+letters&rft.atitle=V-PROLI%2FNO%2C+a+prodrug+of+the+nitric+oxide+donor%2C+PROLI%2FNO.&rft.au=Chakrapani%2C+Harinath%3BShowalter%2C+Brett+M%3BKong%2C+Li%3BKeefer%2C+Larry+K%3BSaavedra%2C+Joseph+E&rft.aulast=Chakrapani&rft.aufirst=Harinath&rft.date=2007-08-16&rft.volume=9&rft.issue=17&rft.spage=3409&rft.isbn=&rft.btitle=&rft.title=Organic+letters&rft.issn=15237060&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-09 N1 - Date created - 2007-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Medical Abortion and the Risk of Subsequent Adverse Pregnancy Outcomes AN - 20449529; 7890519 AB - Background The long-term safety of surgical abortion in the first trimester is well established. Despite the increasing use of medical abortion (abortion by means of medication), limited information is available regarding the effects of this procedure on subsequent pregnancies. Methods We identified all women living in Denmark who had undergone an abortion for nonmedical reasons between 1999 and 2004 and obtained information regarding subsequent pregnancies from national registries. Risks of ectopic pregnancy, spontaneous abortion, preterm birth (at <37 weeks of gestation), and low birth weight (<2500 g) in the first subsequent pregnancy in women who had had a first-trimester medical abortion were compared with risks in women who had had a first-trimester surgical abortion. Results Among 11,814 pregnancies in women who had had a previous first-trimester medical abortion (2710 women) or surgical abortion (9104 women), there were 274 ectopic pregnancies (respective incidence rates, 2.4% and 2.3%), 1426 spontaneous abortions (12.2% and 12.7%), 552 preterm births (5.4% and 6.7%), and 478 births with low birth weight (4.0% and 5.1%). After adjustment for maternal age, interval between pregnancies, gestational age at abortion, parity, cohabitation status, and urban or nonurban residence, medical abortion was not associated with a significantly increased risk of ectopic pregnancy (relative risk, 1.04; 95% confidence interval [CI], 0.76 to 1.41), spontaneous abortion (relative risk, 0.87; 95% CI, 0.72 to 1.05), preterm birth (relative risk, 0.88; 95% CI, 0.66 to 1.18), or low birth weight (relative risk, 0.82; 95% CI, 0.61 to 1.11). Gestational age at medical abortion was not significantly associated with any of these adverse outcomes. Conclusions We found no evidence that a previous medical abortion, as compared with a previous surgical abortion, increases the risk of spontaneous abortion, ectopic pregnancy, preterm birth, or low birth weight. JF - New England Journal of Medicine AU - Virk, J AU - Zhang, J AU - Olsen, J AD - Epidemiology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bldg. 6100, Rm. 7B03, Bethesda, MD 20892, USA, zhangi@mail.nih.gov Y1 - 2007/08/16/ PY - 2007 DA - 2007 Aug 16 SP - 648 EP - 653 VL - 357 IS - 7 SN - 0028-4793, 0028-4793 KW - Risk Abstracts KW - Age KW - parity KW - cohabitation KW - Abortion KW - low-birth-weight KW - Denmark KW - Side effects KW - Pregnancy KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20449529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=New+England+Journal+of+Medicine&rft.atitle=Medical+Abortion+and+the+Risk+of+Subsequent+Adverse+Pregnancy+Outcomes&rft.au=Virk%2C+J%3BZhang%2C+J%3BOlsen%2C+J&rft.aulast=Virk&rft.aufirst=J&rft.date=2007-08-16&rft.volume=357&rft.issue=7&rft.spage=648&rft.isbn=&rft.btitle=&rft.title=New+England+Journal+of+Medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - parity; Age; cohabitation; Abortion; low-birth-weight; Side effects; Pregnancy; Denmark ER - TY - JOUR T1 - Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein. AN - 70704550; 17600340 AB - alpha-Synuclein, a gene whose mutations, duplication, and triplication has been linked to autosomal dominant familial Parkinson's disease (fPD), appears to play a central role in the pathogenesis of sporadic PD (sPD) as well. Enhancement of neurodegeneration induced by mutant alpha-synuclein has been attributed to date largely to faster formation of alpha-synuclein aggregates in neurons. Recently, we reported that microglial activation enhances wild type (WT) alpha-synuclein-elicited dopaminergic neurodegeneration. In the present study, using a primary mesencephalic culture system, we tested whether mutated alpha-synuclein could activate microglia more powerfully than WT alpha-synuclein, thereby contributing to the accelerated neurodegeneration observed in fPD. The results showed that alpha-synuclein with the A30P or A53T mutations caused greater microglial activation than WT alpha-synuclein. Furthermore, the extent of microglial activation paralleled the degree of dopaminergic neurotoxicity induced by WT and mutant alpha-synuclein. Mutant alpha-synuclein also induced greater production of reactive oxygen species than WT alpha-synuclein by NADPH oxidase (PHOX), and PHOX activation was linked to direct activation of macrophage antigen-1 (Mac-1) receptor, rather than alpha-synuclein internalization via scavenger receptors. These results have, for the first time, demonstrated that microglia are also critical in enhanced neurotoxicity induced by mutant alpha-synuclein. (c) 2007 Wiley-Liss, Inc. JF - Glia AU - Zhang, Wei AU - Dallas, Shannon AU - Zhang, Dan AU - Guo, Jian-Ping AU - Pang, Hao AU - Wilson, Belinda AU - Miller, David S AU - Chen, Biao AU - Zhang, Wanqin AU - McGeer, Patrick L AU - Hong, Jau-Shyong AU - Zhang, Jing AD - Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences/National Institutes of Health, Research Triangle Park, North Carolina, USA. Y1 - 2007/08/15/ PY - 2007 DA - 2007 Aug 15 SP - 1178 EP - 1188 VL - 55 IS - 11 SN - 0894-1491, 0894-1491 KW - Macrophage-1 Antigen KW - 0 KW - Reactive Oxygen Species KW - Synucleins KW - NADPH Oxidase KW - EC 1.6.3.1 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Oxygen Consumption -- drug effects KW - Neurotoxicity Syndromes -- physiopathology KW - Mice KW - Mesencephalon -- cytology KW - Rats KW - Mesencephalon -- drug effects KW - Rats, Inbred F344 KW - Cells, Cultured KW - Mutation -- physiology KW - Mice, Inbred C57BL KW - Immunohistochemistry KW - Synucleins -- toxicity KW - Synucleins -- genetics KW - Macrophage-1 Antigen -- physiology KW - Nerve Degeneration -- physiopathology KW - Dopamine -- physiology KW - Nerve Degeneration -- chemically induced KW - NADPH Oxidase -- physiology KW - Microglia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70704550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Glia&rft.atitle=Microglial+PHOX+and+Mac-1+are+essential+to+the+enhanced+dopaminergic+neurodegeneration+elicited+by+A30P+and+A53T+mutant+alpha-synuclein.&rft.au=Zhang%2C+Wei%3BDallas%2C+Shannon%3BZhang%2C+Dan%3BGuo%2C+Jian-Ping%3BPang%2C+Hao%3BWilson%2C+Belinda%3BMiller%2C+David+S%3BChen%2C+Biao%3BZhang%2C+Wanqin%3BMcGeer%2C+Patrick+L%3BHong%2C+Jau-Shyong%3BZhang%2C+Jing&rft.aulast=Zhang&rft.aufirst=Wei&rft.date=2007-08-15&rft.volume=55&rft.issue=11&rft.spage=1178&rft.isbn=&rft.btitle=&rft.title=Glia&rft.issn=08941491&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-18 N1 - Date created - 2007-07-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Family history of gallstones and the risk of biliary tract cancer and gallstones: a population-based study in Shanghai, China. AN - 70655597; 17450525 AB - Cancers of the biliary tract arise from the gallbladder, extrahepatic bile ducts and ampulla of Vater. Although relatively uncommon, the incidence of biliary tract cancer rose more than 100% in Shanghai, China between 1972 and 1994. Gallstones are the predominant risk factor for biliary tract cancers, with over 60% of the cancer cases having gallstones. A familial tendency to gallstones has been reported and may elevate the risk of gallbladder cancer further. As part of a large population-based case-control study of biliary tract cancers in Shanghai, China, we examined the association between a family history of gallstones and biliary tract cancers as well as biliary stones. A total of 627 biliary tract cancers (368 gallbladder, 191 bile duct, 68 ampulla of Vater), 1,037 biliary stone cases (774 gallbladder, 263 bile duct) and 959 healthy subjects randomly selected from the population were included in this study. Information on family history of gallstones among first-degree relatives (i.e., parents, siblings, offspring) was obtained through a self-reported history during in-person interviews. A family history of gallstones was associated with increased risks of biliary stones [odds ratio (OR) = 2.8, 95% confidence interval (CI) = 2.1-3.8], gallbladder cancer (OR = 2.1, 95% CI = 1.4-3.3) and bile duct cancer (OR = 1.5, 95% CI = 0.9-2.5), after adjustment for age, gender, marital status, education, smoking, alcohol drinking and body mass index. For gallbladder cancer, subjects with gallstones but without a family history of gallstones had a 21-fold risk (95% CI 14.8-30.1), while those with both gallstones and a positive family history had a 57-fold risk (95% CI 32.0-110.5). Significant risks for gallbladder cancer persisted after additional adjustment for gallstones, and when the analysis was restricted to subjects with first-degree relatives whose gallstones were treated with cholecystectomy. The significant associations with a family history of gallstones were seen for all first-degree relatives, including parents, siblings and offspring, but not spouses. This large population-based study not only supports the role of gallstones in biliary carcinogenesis but also suggests that the underlying genetic or lifestyle determinants of stones within families contribute to the risk of biliary tract cancer. JF - International journal of cancer AU - Hsing, Ann W AU - Bai, Yan AU - Andreotti, Gabriella AU - Rashid, Asif AU - Deng, Jie AU - Chen, Jinbo AU - Goldstein, Alisa M AU - Han, Tian-Quan AU - Shen, Ming-Chang AU - Fraumeni, Joseph F AU - Gao, Yu-Tang AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD 20852, USA. hsinga@mail.nih.gov Y1 - 2007/08/15/ PY - 2007 DA - 2007 Aug 15 SP - 832 EP - 838 VL - 121 IS - 4 SN - 0020-7136, 0020-7136 KW - Index Medicus KW - Risk Factors KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Family Health KW - Male KW - Female KW - China KW - Gallstones -- epidemiology KW - Biliary Tract Neoplasms -- epidemiology KW - Gallstones -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70655597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Family+history+of+gallstones+and+the+risk+of+biliary+tract+cancer+and+gallstones%3A+a+population-based+study+in+Shanghai%2C+China.&rft.au=Hsing%2C+Ann+W%3BBai%2C+Yan%3BAndreotti%2C+Gabriella%3BRashid%2C+Asif%3BDeng%2C+Jie%3BChen%2C+Jinbo%3BGoldstein%2C+Alisa+M%3BHan%2C+Tian-Quan%3BShen%2C+Ming-Chang%3BFraumeni%2C+Joseph+F%3BGao%2C+Yu-Tang&rft.aulast=Hsing&rft.aufirst=Ann&rft.date=2007-08-15&rft.volume=121&rft.issue=4&rft.spage=832&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-12 N1 - Date created - 2007-07-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Surg Laparosc Endosc Percutan Tech. 2004 Oct;14(5):250-3 [15492651] Annu Rev Genomics Hum Genet. 2000;1:507-37 [11701639] Science. 1986 Apr 4;232(4746):34-47 [3513311] Int J Cancer. 1988 May 15;41(5):657-60 [3366486] J Lipid Res. 1988 Apr;29(4):397-429 [3292686] Jpn J Cancer Res. 1989 Oct;80(10):932-8 [2515177] Int J Cancer. 1992 Jul 9;51(5):707-11 [1612778] Scand J Gastroenterol. 1994 Jul;29(7):577-82 [7939392] Hepatology. 1995 Jul;22(1):138-41 [7601405] Cancer. 1995 Nov 15;76(10):1747-56 [8625043] Int J Cancer. 1998 Jan 30;75(3):368-70 [9455795] Dig Dis Sci. 1998 Jun;43(6):1285-91 [9635619] Am J Gastroenterol. 1998 Sep;93(9):1420-4 [9732918] Gastroenterology. 1998 Oct;115(4):937-46 [9753497] Gastroenterol Clin North Am. 1999 Mar;28(1):99-115 [10198780] Dig Dis Sci. 1999 Aug;44(8):1619-25 [10492143] Zhonghua Wai Ke Za Zhi. 2005 Apr 1;43(7):455-9 [15854373] Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1315-8 [15894693] Int J Cancer. 2006 Jun 1;118(11):2847-53 [16381022] Int J Cancer. 2006 Jun 15;118(12):3089-94 [16395699] Carcinogenesis. 2006 Jun;27(6):1251-6 [16361272] Int J Cancer. 2007 May 1;120(9):1981-5 [17278101] Br J Cancer. 2007 Dec 3;97(11):1577-82 [18000509] CA Cancer J Clin. 2001 Nov-Dec;51(6):349-64 [11760569] Zhonghua Liu Xing Bing Xue Za Zhi. 2000 Feb;21(1):44-7 [11860758] Ann Surg. 2002 Jun;235(6):842-9 [12035041] Clin Cancer Res. 2002 Oct;8(10):3156-63 [12374683] Hum Genet. 2004 Feb;114(3):280-3 [14618390] Clin Cancer Res. 2004 Mar 1;10(5):1717-25 [15014024] Am J Clin Nutr. 2000 Nov;72(5 Suppl):1275S-1284S [11063469] Am J Gastroenterol. 1985 May;80(5):371-5 [3993637] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Use of a cytokine gene expression signature in lung adenocarcinoma and the surrounding tissue as a prognostic classifier. AN - 68172677; 17686824 AB - A 17-cytokine gene expression signature in noncancerous hepatic tissue from patients with metastatic hepatocellular carcinoma (HCC) was recently found to predict HCC metastasis and recurrence. We examined whether the cytokine gene expression profile of noncancerous lung tissue could predict the metastatic capability of adjacent lung adenocarcinoma. We analyzed a 15-cytokine gene expression profile in noncancerous lung tissue and corresponding lung tumor tissue from 80 US lung adenocarcinoma patients using real-time quantitative reverse transcription-polymerase chain reaction. We then used unsupervised hierarchical clustering and Prediction Analysis of Microarray classification to test the prognostic ability of the 15-cytokine gene profile in the US patients and in an independent validation set comprising 50 Japanese patients with stage I disease. Survival was analyzed by the Kaplan-Meier method using the log-rank test, and univariate and multivariable Cox proportional hazards modeling were used to analyze the association of clinical variables with patient survival. All statistical tests were two-sided. A 15-cytokine gene signature in noncancerous lung tissue primarily reflected the lymph node status of 80 lung adenocarcinoma patients, whereas the gene signature of the corresponding lung tumor tissue was associated with prognosis independent of lymph node status. Cytokine Lung Adenocarcinoma Survival Signature of 11 genes (CLASS-11), a refined 11-gene signature, accurately classified patients, including those with stage I disease, according to risk of death from adenocarcinoma. CLASS-11 prognostic classification was statistically significantly associated with survival and was an independent prognostic factor for stage I patients (hazard ratio for death in the high-risk CLASS-11 group compared with the low-risk CLASS-11 reference group = 7.46, 95% confidence interval = 2.14 to 26.05; P = .002). CLASS-11 also classified patients in the validation set according to risk of recurrence. CLASS-11, which consists of genes for pro- and anti-inflammatory cytokines, identifies stage I lung adenocarcinoma patients who have a poor prognosis. JF - Journal of the National Cancer Institute AU - Seike, Masahiro AU - Yanaihara, Nozomu AU - Bowman, Elise D AU - Zanetti, Krista A AU - Budhu, Anuradha AU - Kumamoto, Kensuke AU - Mechanic, Leah E AU - Matsumoto, Shingo AU - Yokota, Jun AU - Shibata, Tatsuhiro AU - Sugimura, Haruhiko AU - Gemma, Akihiko AU - Kudoh, Shoji AU - Wang, Xin W AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4258, USA. Y1 - 2007/08/15/ PY - 2007 DA - 2007 Aug 15 SP - 1257 EP - 1269 VL - 99 IS - 16 KW - Cytokines KW - 0 KW - Index Medicus KW - Neoplasm Staging KW - Humans KW - Prognosis KW - Lymph Nodes -- pathology KW - Lung -- pathology KW - Lung -- metabolism KW - Male KW - Female KW - Gene Expression Profiling KW - Cytokines -- genetics KW - Adenocarcinoma -- mortality KW - Adenocarcinoma -- classification KW - Adenocarcinoma -- secondary KW - Lung Neoplasms -- mortality KW - Lung Neoplasms -- classification KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68172677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Use+of+a+cytokine+gene+expression+signature+in+lung+adenocarcinoma+and+the+surrounding+tissue+as+a+prognostic+classifier.&rft.au=Seike%2C+Masahiro%3BYanaihara%2C+Nozomu%3BBowman%2C+Elise+D%3BZanetti%2C+Krista+A%3BBudhu%2C+Anuradha%3BKumamoto%2C+Kensuke%3BMechanic%2C+Leah+E%3BMatsumoto%2C+Shingo%3BYokota%2C+Jun%3BShibata%2C+Tatsuhiro%3BSugimura%2C+Haruhiko%3BGemma%2C+Akihiko%3BKudoh%2C+Shoji%3BWang%2C+Xin+W%3BHarris%2C+Curtis+C&rft.aulast=Seike&rft.aufirst=Masahiro&rft.date=2007-08-15&rft.volume=99&rft.issue=16&rft.spage=1257&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-05 N1 - Date created - 2007-08-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pseudohypoxic pathways in renal cell carcinoma. AN - 68166368; 17699843 AB - Mutations of the von Hippel-Lindau (VHL) or fumarate hydratase (FH) genes lead to morphologically different renal cell carcinomas with distinct clinical courses and outcomes. The VHL protein is a part of an ubiquitin ligase complex that targets proteins for proteosomal degradation. FH is one of the mitochondrial enzymes of the Kreb's cycle. Despite two different functionalities and cellular locations, loss of either VHL or FH products has been shown to alter expression levels of hypoxia-inducible factors (HIF-1alpha and HIF-2alpha) and their downstream targets. HIF proteins are key regulators of oxygen homeostasis. Tight regulation of HIF allows for cell survival and growth at the time of hypoxic stress. HIF acts via transcriptional regulation of vascular endothelial growth factor, platelet derived growth factor, endothelial growth factor receptor, glucose transporter protein 1, erythropoietin, and transforming growth factor-alpha. Loss of VHL or FH is thought to result in a pseudohypoxic state so that cellular response pathways mediated by HIF are activated despite normal oxygen conditions. Understanding of these pseudohypoxic pathways has provided a better appreciation of the molecular mechanisms of carcinogenesis in addition to providing a rationale for targeted therapeutic approaches. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Bratslavsky, Gennady AU - Sudarshan, Sunil AU - Neckers, Len AU - Linehan, W Marston AD - Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-1107, USA. Y1 - 2007/08/15/ PY - 2007 DA - 2007 Aug 15 SP - 4667 EP - 4671 VL - 13 IS - 16 SN - 1078-0432, 1078-0432 KW - HIG1 protein, human KW - 0 KW - Neoplasm Proteins KW - Von Hippel-Lindau Tumor Suppressor Protein KW - EC 2.3.2.27 KW - Fumarate Hydratase KW - EC 4.2.1.2 KW - VHL protein, human KW - EC 6.3.2.- KW - Index Medicus KW - Animals KW - Neoplasm Proteins -- physiology KW - Fumarate Hydratase -- physiology KW - Von Hippel-Lindau Tumor Suppressor Protein -- physiology KW - Humans KW - Von Hippel-Lindau Tumor Suppressor Protein -- genetics KW - Fumarate Hydratase -- genetics KW - Kidney Neoplasms -- genetics KW - Carcinoma, Renal Cell -- etiology KW - Kidney Neoplasms -- etiology KW - Cell Hypoxia KW - Carcinoma, Renal Cell -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68166368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Pseudohypoxic+pathways+in+renal+cell+carcinoma.&rft.au=Bratslavsky%2C+Gennady%3BSudarshan%2C+Sunil%3BNeckers%2C+Len%3BLinehan%2C+W+Marston&rft.aulast=Bratslavsky&rft.aufirst=Gennady&rft.date=2007-08-15&rft.volume=13&rft.issue=16&rft.spage=4667&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-25 N1 - Date created - 2007-08-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Using risk-based sampling to enrich cohorts for endpoints, genes, and exposures. AN - 68100913; 17556763 AB - Targeting the first-degree relatives of people with a particular complex disease can offer a powerful approach to building a risk-based cohort for prospective studies of etiologic factors. Such a cohort provides both a sizable increase in the rate of accrual of newly incident cases, enriching for risk factors that are known or even unknown, and a high level of motivation among participants. A nationwide study of breast cancer in the United States and Puerto Rico, the Sister Study, made up of women who are each the sister of a woman with breast cancer, exemplifies this approach. In this paper, the authors provide power calculations to aid in the design of such studies and quantify their benefits for detecting both genetic variants related to risk and interactive effects of genetic and environmental factors. While the risk-based cohort can have markedly increased prevalences of rare causative alleles, most of the power advantages for this design is due to the increased rate of accrual of newly incident cases rather than the increase in any one individual allele. JF - American journal of epidemiology AU - Weinberg, Clarice R AU - Shore, David L AU - Umbach, David M AU - Sandler, Dale P AD - Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. weinberg@niehs.nih.gov Y1 - 2007/08/15/ PY - 2007 DA - 2007 Aug 15 SP - 447 EP - 455 VL - 166 IS - 4 SN - 0002-9262, 0002-9262 KW - Index Medicus KW - Breast Neoplasms -- genetics KW - Genetic Variation KW - Disease Susceptibility KW - Endpoint Determination KW - Gene Frequency KW - Humans KW - Breast Neoplasms -- epidemiology KW - Genotype KW - Risk KW - Prospective Studies KW - Breast Neoplasms -- etiology KW - Siblings KW - Female KW - Prevalence KW - Cohort Studies KW - Environmental Exposure -- adverse effects KW - Epidemiologic Research Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68100913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Using+risk-based+sampling+to+enrich+cohorts+for+endpoints%2C+genes%2C+and+exposures.&rft.au=Weinberg%2C+Clarice+R%3BShore%2C+David+L%3BUmbach%2C+David+M%3BSandler%2C+Dale+P&rft.aulast=Weinberg&rft.aufirst=Clarice&rft.date=2007-08-15&rft.volume=166&rft.issue=4&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-31 N1 - Date created - 2007-07-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genet Epidemiol. 2003 Nov;25(3):190-202 [14557987] N Engl J Med. 2000 Jul 13;343(2):78-85 [10891514] J Natl Cancer Inst. 2006 Apr 5;98(7):436-8 [16595777] Br J Cancer. 2006 Jun 5;94(11):1734-7 [16641898] Am J Hum Genet. 2000 Jan;66(1):251-61 [10631155] Lancet. 2001 Oct 27;358(9291):1389-99 [11705483] Pediatrics. 2004 May;113(5):e472-86 [15121991] Epidemiology. 2005 May;16(3):294-303 [15824543] Am J Epidemiol. 1998 Nov 1;148(9):893-901 [9801020] Stat Med. 1997 Jan 15-Feb 15;16(1-3):103-16 [9004386] Am J Epidemiol. 1992 Nov 1;136(9):1138-47 [1462973] Am J Epidemiol. 1991 Aug 15;134(4):421-32 [1877602] Lancet. 1980 Feb 16;1(8164):339-40 [6101792] Am J Epidemiol. 1982 Jan;115(1):119-28 [7055123] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intramedullary spinal tumor causing belly dancer syndrome AN - 21164539; 11350395 AB - Abstract not available. JF - Movement Disorders AU - Shamim, Ejaz A AU - Hallett, Mark AD - Human Motor Control Section, National Institute of Neurologic Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA, shamime@ninds.nih.gov Y1 - 2007/08/15/ PY - 2007 DA - 2007 Aug 15 SP - 1673 EP - 1674 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 22 IS - 11 SN - 0885-3185, 0885-3185 KW - Physical Education Index; CSA Neurosciences Abstracts KW - Movement disorders KW - Abdomen KW - Tumors KW - PE 110:Physical Therapy KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21164539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+Disorders&rft.atitle=Intramedullary+spinal+tumor+causing+belly+dancer+syndrome&rft.au=Shamim%2C+Ejaz+A%3BHallett%2C+Mark&rft.aulast=Shamim&rft.aufirst=Ejaz&rft.date=2007-08-15&rft.volume=22&rft.issue=11&rft.spage=1673&rft.isbn=&rft.btitle=&rft.title=Movement+Disorders&rft.issn=08853185&rft_id=info:doi/10.1002%2Fmds.21280 LA - English DB - Physical Education Index N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Abdomen; Tumors; Movement disorders DO - http://dx.doi.org/10.1002/mds.21280 ER - TY - JOUR T1 - Correlates of 'Non-Problematic' and 'Problematic' Substance Use Among Depressed Adolescents in Primary Care AN - 57090218; 200802066 AB - Substance use and related problems were assessed in a sample of primary care patients (n = 450) ages 13-21 who screened positive for depression at a clinic visit. Patients were classified as having no substance use (n = 248), non-problematic use (substance use without reported school, work, social, or family problems, n = 90), or use that reportedly caused problems in at least one area (n = 112). In logistic regression models, older age, externalizing symptoms, and not being African American were significantly associated with non-problematic use; older age, male gender, externalizing symptoms, Caucasian/White ethnicity/race, and more friends were associated with problematic use. Odds ratios were similar for patients reporting non-problematic and problematic use, suggesting that, in the presence of depression, any substance use merits evaluation and monitoring to determine treatment needs and to prevent escalation of dysfunction. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Journal of Addictive Diseases AU - Goldstein, Rise B AU - Asarnow, Joan R AU - Jaycox, Lisa H AU - Shoptaw, Steven AU - Murray, Pamela J AD - MPH, Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20892-9304 Y1 - 2007/08/14/ PY - 2007 DA - 2007 Aug 14 SP - 39 EP - 52 PB - Haworth Press, Binghamton NY VL - 26 IS - 3 SN - 1055-0887, 1055-0887 KW - Depression KW - Emotionally disturbed adolescents KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57090218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Addictive+Diseases&rft.atitle=Correlates+of+%27Non-Problematic%27+and+%27Problematic%27+Substance+Use+Among+Depressed+Adolescents+in+Primary+Care&rft.au=Goldstein%2C+Rise+B%3BAsarnow%2C+Joan+R%3BJaycox%2C+Lisa+H%3BShoptaw%2C+Steven%3BMurray%2C+Pamela+J&rft.aulast=Goldstein&rft.aufirst=Rise&rft.date=2007-08-14&rft.volume=26&rft.issue=3&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Journal+of+Addictive+Diseases&rft.issn=10550887&rft_id=info:doi/10.1300%2FJ069v26n03_05 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-02-04 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDER N1 - SubjectsTermNotLitGenreText - Emotionally disturbed adolescents; Depression; Substance abuse DO - http://dx.doi.org/10.1300/J069v26n03_05 ER - TY - JOUR T1 - The human Mi-2/NuRD complex and gene regulation. AN - 68157500; 17694084 AB - The Mi-2/nucleosome remodeling and deacetylase (NuRD) complex is an abundant deacetylase complex with a broad cellular and tissue distribution. It is unique in that it couples histone deacetylation and chromatin remodeling ATPase activities in the same complex. A decade of research has uncovered a number of interesting connections between Mi-2/NuRD and gene regulation. The subunit composition of the enzyme appears to vary with cell type and in response to physiologic signals within a tissue. Here, we review the known subunits of the complex, their connections to signaling networks, and their association with cancer. In addition, we propose a working model that integrates the known biochemical properties of the enzyme with emerging models on how chromatin structure and modification relate to gene activity. JF - Oncogene AU - Denslow, S A AU - Wade, P A AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. Y1 - 2007/08/13/ PY - 2007 DA - 2007 Aug 13 SP - 5433 EP - 5438 VL - 26 IS - 37 SN - 0950-9232, 0950-9232 KW - Autoantigens KW - 0 KW - CHD4 protein, human KW - Neoplasm Proteins KW - Repressor Proteins KW - Histone Deacetylases KW - EC 3.5.1.98 KW - Mi-2 Nucleosome Remodeling and Deacetylase Complex KW - Adenosine Triphosphatases KW - EC 3.6.1.- KW - DNA Helicases KW - EC 3.6.4.- KW - Index Medicus KW - Animals KW - DNA Methylation KW - Humans KW - Repressor Proteins -- metabolism KW - Retinoblastoma -- metabolism KW - Neoplasm Proteins -- metabolism KW - Neoplasms -- pathology KW - Neoplasms -- enzymology KW - DNA Helicases -- metabolism KW - Histone Deacetylases -- metabolism KW - DNA Helicases -- genetics KW - Adenosine Triphosphatases -- metabolism KW - Autoantigens -- genetics KW - Gene Expression Regulation KW - Autoantigens -- metabolism KW - Histone Deacetylases -- genetics KW - Adenosine Triphosphatases -- genetics KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68157500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=The+human+Mi-2%2FNuRD+complex+and+gene+regulation.&rft.au=Denslow%2C+S+A%3BWade%2C+P+A&rft.aulast=Denslow&rft.aufirst=S&rft.date=2007-08-13&rft.volume=26&rft.issue=37&rft.spage=5433&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-24 N1 - Date created - 2007-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Restoration of 3,4-methylenedioxymethamphetamine-induced 5-HT depletion by the administration of L-5-hydroxytryptophan. AN - 68160304; 17629409 AB - 3,4-Methylenedioxymethamphetamine (MDMA) causes persistent decreases in brain 5-HT content and 5-HT transporter (SERT) binding, with no detectable changes in SERT protein. Such data suggest that MDMA impairs 5-HT transmission but leaves 5-HT nerve terminals intact. To further test this hypothesis, we carried out two types of experiments in rats exposed to high-dose MDMA. First, we examined the effects of MDMA on SERT binding and function using different in vitro assay conditions. Next, we treated rats with the 5-HT precursor, l-5-hydroxytryptophan (5-HTP), in an attempt to restore MDMA-induced depletions of 5-HT. Rats received three i.p. injections of saline or MDMA (7.5 mg/kg), one injection every 2 h. Rats in one group were decapitated, and brain tissue was assayed for SERT binding and [(3)H]5-HT uptake under conditions of normal (100 or 126 mM) and low (20 mM) NaCl concentration. Rats from another group received saline or 5-hydroxytryptophan/benserazide (5-HTP-B), each drug at 50 mg/kg i.p., and were killed 2 h later. MDMA reduced SERT binding to 10% of control when assayed in 100 mM NaCl, but this reduction was only 55% of control in 20 mM NaCl. MDMA decreased immunoreactive 5-HT in caudate and hippocampus to about 35% of control. Administration of 5-HTP-B to MDMA-pretreated rats significantly increased the 5-HT signal toward normal levels in caudate (85% of control) and hippocampus (66% of control). 1) Following high-dose MDMA treatment sufficient to reduce SERT binding by 90%, a significant number of functionally intact 5-HT nerve terminals survive. 2) The degree of MDMA-induced decreases in SERT binding depends on the in vitro assay conditions. 3) 5-HTP-B restores brain 5-HT depleted by MDMA, suggesting that this approach might be clinically useful in abstinent MDMA users. JF - Neuroscience AU - Wang, X AU - Baumann, M H AU - Dersch, C M AU - Rothman, R B AD - Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, P.O. Box 5180, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. Y1 - 2007/08/10/ PY - 2007 DA - 2007 Aug 10 SP - 212 EP - 220 VL - 148 IS - 1 SN - 0306-4522, 0306-4522 KW - Antidepressive Agents, Second-Generation KW - 0 KW - Hallucinogens KW - Serotonin Agents KW - Serotonin Plasma Membrane Transport Proteins KW - Serotonin KW - 333DO1RDJY KW - 5-Hydroxytryptophan KW - C1LJO185Q9 KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Index Medicus KW - Animals KW - Nerve Degeneration -- physiopathology KW - Serotonin Plasma Membrane Transport Proteins -- drug effects KW - Nerve Degeneration -- chemically induced KW - Recovery of Function -- physiology KW - Radioligand Assay KW - Recovery of Function -- drug effects KW - Presynaptic Terminals -- metabolism KW - Nerve Degeneration -- drug therapy KW - Rats KW - Presynaptic Terminals -- drug effects KW - Cell Survival -- drug effects KW - Male KW - Hallucinogens -- antagonists & inhibitors KW - Antidepressive Agents, Second-Generation -- pharmacology KW - Serotonin Plasma Membrane Transport Proteins -- metabolism KW - Dose-Response Relationship, Drug KW - Synaptic Transmission -- drug effects KW - Binding, Competitive -- physiology KW - Binding, Competitive -- drug effects KW - Synaptic Transmission -- physiology KW - Drug Interactions -- physiology KW - Rats, Sprague-Dawley KW - Serotonin Agents -- pharmacology KW - Serotonin Agents -- toxicity KW - Hallucinogens -- toxicity KW - Cell Survival -- physiology KW - Brain Chemistry -- drug effects KW - Brain -- drug effects KW - 5-Hydroxytryptophan -- pharmacology KW - N-Methyl-3,4-methylenedioxyamphetamine -- toxicity KW - Brain -- metabolism KW - N-Methyl-3,4-methylenedioxyamphetamine -- antagonists & inhibitors KW - Serotonin -- deficiency KW - Brain Chemistry -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68160304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Restoration+of+3%2C4-methylenedioxymethamphetamine-induced+5-HT+depletion+by+the+administration+of+L-5-hydroxytryptophan.&rft.au=Wang%2C+X%3BBaumann%2C+M+H%3BDersch%2C+C+M%3BRothman%2C+R+B&rft.aulast=Wang&rft.aufirst=X&rft.date=2007-08-10&rft.volume=148&rft.issue=1&rft.spage=212&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-14 N1 - Date created - 2007-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity. AN - 68127673; 17678736 AB - We aimed to explore the effects of pharmacologic inhibition of cannabinoid-1 (CB1) receptor in in vivo and in vitro models of doxorubicin (DOX)-induced cardiotoxicity. Doxorubicin is one of the most potent antitumor agents available; however, its clinical use is limited because of the risk of severe cardiotoxicity. Endocannabinoids mediate cardiodepressive effects through CB1 receptors in various pathophysiological conditions, and these effects can be reversed by CB1 antagonists. Left ventricular function was measured by Millar pressure-volume system. Apoptosis markers, CB1/CB2 receptor expression, and endocannabinoid levels were determined by immunohistochemistry, Western blot, reverse transcription-polymerase chain reaction, real-time polymerase chain reaction, flow cytometry, fluorescent microscopy, and liquid chromatography/in-line mass spectrometry techniques. Five days after the administration of a single dose of DOX (20 mg/kg intraperitoneally) to mice, left ventricular systolic pressure, maximum first derivative of ventricular pressure with respect to time (+dP/dt), stroke work, ejection fraction, cardiac output, and load-independent indexes of contractility (end-systolic pressure-volume relation, preload-recruitable stroke work, dP/dt-end-diastolic volume relation) were significantly depressed, and the myocardial level of the endocannabinoid anandamide (but not CB1/CB2 receptor expression) was elevated compared with vehicle-treated control mice. Treatment with the CB1 antagonists rimonabant or AM281 markedly improved cardiac dysfunction and reduced DOX-induced apoptosis in the myocardium. Doxorubicin also decreased cell viability and induced apoptosis in the H9c2 myocardial cell line measured by flow cytometry and fluorescent microscopy, which were prevented by the preincubation of the cells with either CB1 antagonist, but not with CB1 and CB2 agonists and CB2 antagonists. These data suggest that CB1 antagonists may represent a new cardioprotective strategy against DOX-induced cardiotoxicity. JF - Journal of the American College of Cardiology AU - Mukhopadhyay, Partha AU - Bátkai, Sándor AU - Rajesh, Mohanraj AU - Czifra, Nora AU - Harvey-White, Judith AU - Haskó, György AU - Zsengeller, Zsuzsanna AU - Gerard, Norma P AU - Liaudet, Lucas AU - Kunos, George AU - Pacher, Pál AD - Laboratory of Physiological Studies, NIH/NIAAA, Bethesda, Maryland 20892, USA. Y1 - 2007/08/07/ PY - 2007 DA - 2007 Aug 07 SP - 528 EP - 536 VL - 50 IS - 6 KW - AM 281 KW - 0 KW - Antibiotics, Antineoplastic KW - Cannabinoid Receptor Modulators KW - Morpholines KW - Piperidines KW - Pyrazoles KW - Receptor, Cannabinoid, CB1 KW - Receptor, Cannabinoid, CB2 KW - Doxorubicin KW - 80168379AG KW - rimonabant KW - RML78EN3XE KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Myocytes, Cardiac -- drug effects KW - Mice KW - Myocardium -- metabolism KW - Receptor, Cannabinoid, CB2 -- antagonists & inhibitors KW - Cannabinoid Receptor Modulators -- metabolism KW - Apoptosis -- drug effects KW - Mice, Inbred C57BL KW - DNA Fragmentation -- drug effects KW - Receptor, Cannabinoid, CB2 -- agonists KW - Receptor, Cannabinoid, CB2 -- drug effects KW - Cell Line KW - Male KW - Piperidines -- pharmacology KW - Pyrazoles -- pharmacology KW - Heart Failure -- prevention & control KW - Doxorubicin -- adverse effects KW - Receptor, Cannabinoid, CB1 -- antagonists & inhibitors KW - Receptor, Cannabinoid, CB1 -- agonists KW - Piperidines -- therapeutic use KW - Morpholines -- therapeutic use KW - Receptor, Cannabinoid, CB1 -- drug effects KW - Morpholines -- pharmacology KW - Heart Failure -- chemically induced KW - Pyrazoles -- therapeutic use KW - Antibiotics, Antineoplastic -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68127673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.atitle=Pharmacological+inhibition+of+CB1+cannabinoid+receptor+protects+against+doxorubicin-induced+cardiotoxicity.&rft.au=Mukhopadhyay%2C+Partha%3BB%C3%A1tkai%2C+S%C3%A1ndor%3BRajesh%2C+Mohanraj%3BCzifra%2C+Nora%3BHarvey-White%2C+Judith%3BHask%C3%B3%2C+Gy%C3%B6rgy%3BZsengeller%2C+Zsuzsanna%3BGerard%2C+Norma+P%3BLiaudet%2C+Lucas%3BKunos%2C+George%3BPacher%2C+P%C3%A1l&rft.aulast=Mukhopadhyay&rft.aufirst=Partha&rft.date=2007-08-07&rft.volume=50&rft.issue=6&rft.spage=528&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Cardiology&rft.issn=1558-3597&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-24 N1 - Date created - 2007-08-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Antioxid Redox Signal. 2001 Feb;3(1):135-45 [11291592] Physiol Rev. 2007 Jan;87(1):315-424 [17237348] J Am Coll Cardiol. 2001 Dec;38(7):2048-54 [11738314] Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2380-5 [11854531] J Pharmacol Exp Ther. 2002 Mar;300(3):862-7 [11861791] Cancer Res. 2002 Aug 15;62(16):4592-8 [12183413] J Mol Cell Cardiol. 2002 Dec;34(12):1595-607 [12505058] Circulation. 2003 Feb 18;107(6):896-904 [12591762] Br J Pharmacol. 2003 Apr;138(7):1251-8 [12711625] Oncol Rep. 2004 Feb;11(2):505-8 [14719091] J Leukoc Biol. 2004 Mar;75(3):453-9 [14657208] Circulation. 2004 Mar 23;109(11):1428-33 [15023870] Science. 1977 Jul 8;197(4299):165-7 [877547] N Engl J Med. 1981 Jul 16;305(3):139-53 [7017406] J Biol Chem. 1986 Mar 5;261(7):3068-74 [3005279] Drugs. 1997;54 Suppl 4:1-7 [9361955] N Engl J Med. 1998 Sep 24;339(13):900-5 [9744975] Circulation. 2004 Nov 2;110(18):2869-74 [15505089] N Engl J Med. 2005 Nov 17;353(20):2121-34 [16291982] JAMA. 2006 Feb 15;295(7):761-75 [16478899] Handb Exp Pharmacol. 2005;(168):599-625 [16596789] Pharmacol Res. 2006 Apr;53(4):341-6 [16455267] Arch Mal Coeur Vaiss. 2006 Mar;99(3):242-6 [16618028] Circulation. 2006 May 9;113(18):2211-20 [16651473] J Am Coll Cardiol. 2006 May 16;47(10):1919-26 [16697306] J Pharmacol Sci. 2006 Jun;101(2):151-8 [16766856] Eur Heart J. 2006 Aug;27(15):1868-75 [16717080] Pharmacol Rev. 2006 Sep;58(3):389-462 [16968947] J Mol Cell Cardiol. 2006 Sep;41(3):389-405 [16879835] Comment In: J Am Coll Cardiol. 2007 Aug 7;50(6):537-9 [17678737] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease AN - 20406802; 7560371 AB - Gaucher disease is an autosomal recessive lysosomal storage disorder caused by mutations in the glucocerebrosidase gene. Missense mutations result in reduced enzyme activity that may be due to misfolding, raising the possibility of small-molecule chaperone correction of the defect. Screening large compound libraries by quantitative high-throughput screening (qHTS) provides comprehensive information on the potency, efficacy, and structure-activity relationships (SAR) of active compounds directly from the primary screen, facilitating identification of leads for medicinal chemistry optimization. We used qHTS to rapidly identify three structural series of potent, selective, nonsugar glucocerebrosidase inhibitors. The three structural classes had excellent potencies and efficacies and, importantly, high selectivity against closely related hydrolases. Preliminary SAR data were used to select compounds with high activity in both enzyme and cell-based assays. Compounds from two of these structural series increased N370S mutant glucocerebrosidase activity by 40-90% in patient cell lines and enhanced lysosomal colocalization, indicating chaperone activity. These small molecules have potential as leads for chaperone therapy for Gaucher disease, and this paradigm promises to accelerate the development of leads for other rare genetic disorders. JF - Proceedings of the National Academy of Sciences, USA AU - Zheng, Wei AU - Padia, Janak AU - Urban, Daniel J AU - Jadhav, Ajit AU - Goker-Alpan, Ozlem AU - Simeonov, Anton AU - Goldin, Ehud AU - Auld, Douglas AU - LaMarca, Mary E AU - Inglese, James AU - Austin, Christopher P AU - Sidransky, Ellen AD - NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, 9800 Medical Center Drive, MSC 3370, Bethesda, MD 20892-3370 Y1 - 2007/08/07/ PY - 2007 DA - 2007 Aug 07 SP - 13192 EP - 13197 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 32 SN - 0027-8424, 0027-8424 KW - Biotechnology Research Abstracts (through 1992) KW - hydrolase KW - lysosomal storage diseases KW - Missense mutation KW - Hereditary diseases KW - Gaucher's disease KW - Enzymes KW - high-throughput screening KW - Chaperones KW - Glucosylceramidase KW - Structure-activity relationships KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20406802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Three+classes+of+glucocerebrosidase+inhibitors+identified+by+quantitative+high-throughput+screening+are+chaperone+leads+for+Gaucher+disease&rft.au=Zheng%2C+Wei%3BPadia%2C+Janak%3BUrban%2C+Daniel+J%3BJadhav%2C+Ajit%3BGoker-Alpan%2C+Ozlem%3BSimeonov%2C+Anton%3BGoldin%2C+Ehud%3BAuld%2C+Douglas%3BLaMarca%2C+Mary+E%3BInglese%2C+James%3BAustin%2C+Christopher+P%3BSidransky%2C+Ellen&rft.aulast=Zheng&rft.aufirst=Wei&rft.date=2007-08-07&rft.volume=104&rft.issue=32&rft.spage=13192&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Chaperones; Glucosylceramidase; Gaucher's disease; Enzymes; high-throughput screening; Missense mutation; lysosomal storage diseases; Hereditary diseases; hydrolase; Structure-activity relationships ER - TY - JOUR T1 - Viewpoint: mechanisms of action and therapeutic potential of neurohormetic phytochemicals. AN - 733227867; 18648607 AB - The nervous system is of fundamental importance in the adaptive (hormesis) responses of organisms to all types of stress, including environmental "toxins". Phytochemicals present in vegetables and fruits are believed to reduce the risk of several major diseases including cardiovascular disease, cancers and neurodegenerative disorders. Although antioxidant properties have been suggested as the basis of health benefits of phytochemicals, emerging findings suggest a quite different mechanism of action. Many phytochemicals normally function as toxins that protect the plants against insects and other damaging organisms. However, at the relatively low doses consumed by humans and other mammals these same "toxic" phytochemicals activate adaptive cellular stress response pathways that can protect the cells against a variety of adverse conditions. Recent findings have elucidated hormetic mechanisms of action of phytochemicals (e.g., resveratrol, curcumin, sulforaphanes and catechins) using cell culture and animal models of neurological disorders. Examples of hormesis pathways activated by phytochemicals include the transcription factor Nrf-2 which activates genes controlled by the antioxidant response element, and histone deacetylases of the sirtuin family and FOXO transcription factors. Such hormetic pathways stimulate the production of antioxidant enzymes, protein chaperones and neurotrophic factors. In several cases neurohormetic phytochemicals have been shown to suppress the disease process in animal models relevant to neurodegenerative disorders such as Alzheimer's and Parkinson's diseases, and can also improve outcome following a stroke. We are currently screening a panel of biopesticides in order to establish hormetic doses, neuroprotective efficacy, mechanisms of action and therapeutic potential as dietary supplements. JF - Dose-response : a publication of International Hormesis Society AU - Mattson, Mark P AU - Son, Tae Gen AU - Camandola, Simonetta AD - Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD, USA. mattsonm@grc.nia.nih.gov Y1 - 2007/08/06/ PY - 2007 DA - 2007 Aug 06 SP - 174 EP - 186 VL - 5 IS - 3 KW - neurotrophic factor KW - Alzheimer's disease KW - resveratrol KW - nrf2 KW - sirtuin KW - curcumin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733227867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dose-response+%3A+a+publication+of+International+Hormesis+Society&rft.atitle=Viewpoint%3A+mechanisms+of+action+and+therapeutic+potential+of+neurohormetic+phytochemicals.&rft.au=Mattson%2C+Mark+P%3BSon%2C+Tae+Gen%3BCamandola%2C+Simonetta&rft.aulast=Mattson&rft.aufirst=Mark&rft.date=2007-08-06&rft.volume=5&rft.issue=3&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=Dose-response+%3A+a+publication+of+International+Hormesis+Society&rft.issn=1559-3258&rft_id=info:doi/10.2203%2Fdose-response.07-004.Mattson LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-06-09 N1 - Date created - 2008-07-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci Res. 1999 Jul 1;57(1):48-61 [10397635] Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10367-72 [9294217] Cardiovasc Drug Rev. 2004 Fall;22(3):169-88 [15492766] Free Radic Biol Med. 2004 Nov 15;37(10):1578-90 [15477009] Trends Neurosci. 2004 Oct;27(10):589-94 [15374669] Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10446-51 [15229324] Amyotroph Lateral Scler Other Motor Neuron Disord. 2004 Mar;5(1):33-9 [15204022] J Neurosci Res. 2005 Nov 15;82(4):499-506 [16211562] Pharmacol Biochem Behav. 2005 Sep;82(1):200-6 [16171853] J Neurosci Res. 2005 Oct 1;82(1):138-48 [16075466] Neuromolecular Med. 2005;7(1-2):37-50 [16052037] Planta. 2005 Jul;221(5):603-6 [15931500] J Neurochem. 2005 Jun;93(5):1209-19 [15934941] Curr Biol. 2005 May 24;15(10):929-34 [15916949] Crit Rev Food Sci Nutr. 2004;44(2):97-111 [15116757] Science. 2004 Mar 26;303(5666):2011-5 [14976264] J Neurosci. 2004 Feb 4;24(5):1101-12 [14762128] Nature. 2004 Jan 15;427(6971):260-5 [14712238] Mol Cell Biol. 2003 Nov;23(22):8137-51 [14585973] J Neurosci Res. 2006 Sep;84(4):699-715 [16862541] Ann N Y Acad Sci. 2006 May;1067:425-35 [16804022] Neuromolecular Med. 2006;8(3):389-414 [16775390] Am J Pathol. 2003 Nov;163(5):1997-2008 [14578199] Psychopharmacology (Berl). 2003 Sep;169(2):115-34 [12827346] Am J Clin Nutr. 2003 Sep;78(3 Suppl):570S-578S [12936951] Nat Med. 2003 Aug;9(8):1062-8 [12858170] Nutr Neurosci. 2003 Jun;6(3):153-62 [12793519] Neuromolecular Med. 2003;3(2):65-94 [12728191] Biochem J. 2003 May 1;371(Pt 3):887-95 [12570874] Free Radic Biol Med. 2003 Apr 15;34(8):1100-10 [12684095] Curr Opin Plant Biol. 2003 Apr;6(2):185-90 [12667877] J Neurochem. 2002 Sep;82(6):1367-75 [12354284] Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11908-13 [12193649] Hum Exp Toxicol. 2002 Feb;21(2):91-7 [12102503] Physiol Rev. 2002 Jul;82(3):637-72 [12087131] J Neurosci. 2001 Dec 1;21(23):9204-13 [11717354] J Neurosci. 2001 Nov 1;21(21):8370-7 [11606625] Life Sci. 2001 Jul 20;69(9):1057-65 [11508648] J Neurosci. 2001 May 1;21(9):2929-38 [11312276] Br J Pharmacol. 2000 Oct;131(4):711-20 [11030720] Eur J Epidemiol. 2000 Apr;16(4):357-63 [10959944] J Cereb Blood Flow Metab. 1999 Dec;19(12):1296-308 [10598933] Toxicol Appl Pharmacol. 2007 Jul 1;222(1):122-8 [17459441] Amino Acids. 2007;32(3):299-304 [16998712] J Pharmacol Exp Ther. 2007 Apr;321(1):249-56 [17259450] Aging Cell. 2007 Feb;6(1):35-43 [17156081] Biochem Pharmacol. 2007 Feb 15;73(4):550-60 [17147953] Brain Res. 2007 Jan 12;1128(1):61-9 [17140550] Cell. 2006 Dec 15;127(6):1109-22 [17112576] J Biol Chem. 2006 Dec 8;281(49):37391-403 [17035241] Nutrition. 2006 Nov-Dec;22(11-12):1177-84 [17027231] Neurobiol Dis. 2006 Dec;24(3):506-15 [17010630] Nature. 2006 Nov 16;444(7117):337-42 [17086191] FASEB J. 2006 Nov;20(13):2313-20 [17077308] Trends Neurosci. 2006 Nov;29(11):632-9 [17000014] Eur J Clin Nutr. 2006 Oct;60(10):1145-59 [16670693] Ageing Res Rev. 2006 Aug;5(3):332-53 [16899414] Ageing Res Rev. 2006 May;5(2):165-78 [16682262] Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):395-403 [16677086] J Neurosci. 2006 Apr 26;26(17):4509-18 [16641230] Cell Death Differ. 2006 May;13(5):852-60 [16397579] Neurosci Lett. 2005 Dec 2;389(2):99-103 [16098661] Handb Exp Pharmacol. 2005;(168):53-79 [16596771] Crit Rev Toxicol. 2005 Jul;35(6):463-582 [16422392] Exp Neurol. 2006 Feb;197(2):309-17 [16364299] Neurosci Lett. 2006 Jan 30;393(2-3):108-12 [16233958] J Alzheimers Dis. 2005 Dec;8(3):283-7 [16340085] Proc Nutr Soc. 2005 Nov;64(4):565-70 [16313699] Ann Thorac Surg. 2005 Dec;80(6):2242-9 [16305881] Exp Neurol. 2005 Dec;196(2):298-307 [16176814] J Biol Chem. 2005 Nov 11;280(45):37377-82 [16162502] J Biol Chem. 2005 May 27;280(21):20589-95 [15788402] Neurobiol Dis. 2005 Jun-Jul;19(1-2):96-107 [15837565] Brain Res Mol Brain Res. 2005 Apr 4;134(2):215-25 [15836919] Exp Neurol. 2005 May;193(1):75-84 [15817266] Nat Genet. 2005 Apr;37(4):349-50 [15793589] Curr Opin Clin Nutr Metab Care. 2005 Mar;8(2):139-46 [15716791] Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18171-6 [15604149] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.2203/dose-response.07-004.Mattson ER - TY - JOUR T1 - Paradoxes in carcinogenesis: new opportunities for research directions. AN - 68313338; 17683619 AB - The prevailing paradigm in cancer research is the somatic mutation theory that posits that cancer begins with a single mutation in a somatic cell followed by successive mutations. Much cancer research involves refining the somatic mutation theory with an ever increasing catalog of genetic changes. The problem is that such research may miss paradoxical aspects of carcinogenesis for which there is no likely explanation under the somatic mutation theory. These paradoxical aspects offer opportunities for new research directions that should not be ignored. Various paradoxes related to the somatic mutation theory of carcinogenesis are discussed: (1) the presence of large numbers of spatially distinct precancerous lesions at the onset of promotion, (2) the large number of genetic instabilities found in hyperplastic polyps not considered cancer, (3) spontaneous regression, (4) higher incidence of cancer in patients with xeroderma pigmentosa but not in patients with other comparable defects in DNA repair, (5) lower incidence of many cancers except leukemia and testicular cancer in patients with Down's syndrome, (6) cancer developing after normal tissue is transplanted to other parts of the body or next to stroma previously exposed to carcinogens, (7) the lack of tumors when epithelial cells exposed to a carcinogen were transplanted next to normal stroma, (8) the development of cancers when Millipore filters of various pore sizes were was inserted under the skin of rats, but only if the holes were sufficiently small. For the latter paradox, a microarray experiment is proposed to try to better understand the phenomena. The famous physicist Niels Bohr said "How wonderful that we have met with a paradox. Now we have some hope of making progress." The same viewpoint should apply to cancer research. It is easy to ignore this piece of wisdom about the means to advance knowledge, but we do so at our peril. JF - BMC cancer AU - Baker, Stuart G AU - Kramer, Barnett S AD - Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA. sb16i@nih.gov Y1 - 2007/08/06/ PY - 2007 DA - 2007 Aug 06 SP - 151 VL - 7 KW - Carcinogens KW - 0 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Rats KW - Neoplasm Regression, Spontaneous KW - Carcinogens -- pharmacology KW - Animals KW - DNA Repair KW - Humans KW - Mutation KW - Neoplasms -- pathology KW - Research -- trends KW - Neoplasms -- genetics KW - Neoplasms -- etiology KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68313338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+cancer&rft.atitle=Paradoxes+in+carcinogenesis%3A+new+opportunities+for+research+directions.&rft.au=Baker%2C+Stuart+G%3BKramer%2C+Barnett+S&rft.aulast=Baker&rft.aufirst=Stuart&rft.date=2007-08-06&rft.volume=7&rft.issue=&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=BMC+cancer&rft.issn=1471-2407&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-16 N1 - Date created - 2007-09-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14675-7 [10611270] Proc Natl Acad Sci U S A. 1976 Feb;73(2):549-53 [1061157] Proc Natl Acad Sci U S A. 1986 Dec;83(23):8878-82 [3466163] Cancer Res. 1994 Oct 15;54(20):5296-300 [7923156] J Cell Biol. 1997 Apr 7;137(1):231-45 [9105051] Technol Health Care. 1997 Oct;5(4):331-4 [9429273] Cancer Res. 1998 Oct 1;58(19):4314-23 [9766659] Cell. 1999 Jul 23;98(2):137-46 [10428026] Int J Cancer. 2005 Jan 1;113(1):168-70 [15386432] Br Med Bull. 1958 May;14(2):99-101 [13536368] Lancet. 1962 Jul 21;2(7247):107-12 [14484229] Prog Exp Tumor Res. 1964;5:85-133 [14317768] Lancet. 2005 Feb 5-11;365(9458):488-92 [15705458] J Biosci. 2005 Feb;30(1):103-18 [15824446] Breast Cancer. 2005;12(2):140-4 [15858446] Cancer Biol Ther. 2005 Jun;4(6):621-7 [15970666] Int J Cancer. 2006 Apr 1;118(7):1769-72 [16231334] BMC Bioinformatics. 2006;7:407 [16959042] J Mol Histol. 2006 Sep;37(5-7):225-38 [16855787] Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15121-6 [10611348] Lancet. 2000 Jan 15;355(9199):165-9 [10675114] Cancer Res. 2000 Mar 1;60(5):1254-60 [10728684] Mol Carcinog. 2000 Dec;29(4):205-11 [11170258] Lancet. 2002 Mar 23;359(9311):1019-25 [11937181] Nat Rev Cancer. 2004 Mar;4(3):197-205 [14993901] J Cell Sci. 2004 Mar 15;117(Pt 8):1495-502 [14996910] Bioessays. 2004 Oct;26(10):1097-107 [15382143] J Natl Cancer Inst. 1966 Aug;37(2):145-51 [5912611] J Natl Cancer Inst. 1972 Apr;48(4):1251-4 [5023683] J Natl Cancer Inst. 1973 Oct;51(4):1275-85 [4583375] Nature. 1981 Jan 29;289(5796):353-7 [6258076] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A trial of 17 alpha-hydroxyprogesterone caproate to prevent prematurity in twins. AN - 68121816; 17671253 AB - In singleton gestations, 17 alpha-hydroxyprogesterone caproate (17P) has been shown to reduce the rate of recurrent preterm birth. This study was undertaken to evaluate whether 17P would reduce the rate of preterm birth in twin gestations. We performed a randomized, double-blind, placebo-controlled trial in 14 centers. Healthy women with twin gestations were assigned to weekly intramuscular injections of 250 mg of 17P or matching placebo, starting at 16 to 20 weeks of gestation and ending at 35 weeks. The primary study outcome was delivery or fetal death before 35 weeks of gestation. Six hundred sixty-one women were randomly assigned to treatment. Baseline demographic data were similar in the two study groups. Six women were lost to follow-up; data from 655 were analyzed (325 in the 17P group and 330 in the placebo group). Delivery or fetal death before 35 weeks occurred in 41.5% of pregnancies in the 17P group and 37.3% of those in the placebo group (relative risk, 1.1; 95% confidence interval [CI], 0.9 to 1.3). The rate of the prespecified composite outcome of serious adverse fetal or neonatal events was 20.2% in the 17P group and 18.0% in the placebo group (relative risk, 1.1; 95% CI, 0.9 to 1.5). Side effects of the injections were frequent in both groups, occurring in 65.9% and 64.4% of subjects, respectively (P=0.69), but were generally mild and limited to the injection site. Treatment with 17 alpha-hydroxyprogesterone caproate did not reduce the rate of preterm birth in women with twin gestations. (ClinicalTrials.gov number, NCT00099164 [ClinicalTrials.gov].). Copyright 2007 Massachusetts Medical Society. JF - The New England journal of medicine AU - Rouse, Dwight J AU - Caritis, Steve N AU - Peaceman, Alan M AU - Sciscione, Anthony AU - Thom, Elizabeth A AU - Spong, Catherine Y AU - Varner, Michael AU - Malone, Fergal AU - Iams, Jay D AU - Mercer, Brian M AU - Thorp, John AU - Sorokin, Yoram AU - Carpenter, Marshall AU - Lo, Julie AU - Ramin, Susan AU - Harper, Margaret AU - Anderson, Garland AU - National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network AD - Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham 35249-7333, USA. drouse@uab.edu ; National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network Y1 - 2007/08/02/ PY - 2007 DA - 2007 Aug 02 SP - 454 EP - 461 VL - 357 IS - 5 KW - Hydroxyprogesterones KW - 0 KW - Progesterone Congeners KW - 17-alpha-hydroxy-progesterone caproate KW - 276F2O42F5 KW - Abridged Index Medicus KW - Index Medicus KW - Treatment Failure KW - Double-Blind Method KW - Humans KW - Injections, Intramuscular KW - Adult KW - Female KW - Pregnancy Outcome KW - Pregnancy KW - Hydroxyprogesterones -- therapeutic use KW - Twins KW - Progesterone Congeners -- adverse effects KW - Premature Birth -- prevention & control KW - Pregnancy, Multiple KW - Hydroxyprogesterones -- adverse effects KW - Progesterone Congeners -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68121816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=A+trial+of+17+alpha-hydroxyprogesterone+caproate+to+prevent+prematurity+in+twins.&rft.au=Rouse%2C+Dwight+J%3BCaritis%2C+Steve+N%3BPeaceman%2C+Alan+M%3BSciscione%2C+Anthony%3BThom%2C+Elizabeth+A%3BSpong%2C+Catherine+Y%3BVarner%2C+Michael%3BMalone%2C+Fergal%3BIams%2C+Jay+D%3BMercer%2C+Brian+M%3BThorp%2C+John%3BSorokin%2C+Yoram%3BCarpenter%2C+Marshall%3BLo%2C+Julie%3BRamin%2C+Susan%3BHarper%2C+Margaret%3BAnderson%2C+Garland%3BNational+Institute+of+Child+Health+and+Human+Development+Maternal-Fetal+Medicine+Units+Network&rft.aulast=Rouse&rft.aufirst=Dwight&rft.date=2007-08-02&rft.volume=357&rft.issue=5&rft.spage=454&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-09 N1 - Date created - 2007-08-02 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - NCT00099164; ClinicalTrials.gov N1 - SuppNotes - Comment In: N Engl J Med. 2007 Nov 29;357(22):2306; author reply 2307 [18050514] N Engl J Med. 2007 Aug 2;357(5):499-501 [17671259] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells AN - 21335173; 11935012 AB - Epithelial stem cells in the bulge region within the hair follicle maintain the cyclic hair growth, but whether these stem cells also contribute to the epidermal renewal remains unclear. Here, we observed that the conditional deletion of the Rac1 gene in the mouse skin, including the potential follicular and epidermal stem cell compartments, results in alopecia owing to defective hair development. Surprisingly, mice lacking the expression of this Rho GTPase do not display major alterations in the interfollicular skin. Furthermore, Rac1 excision from primary epithelial keratinocytes results in the inability to reconstitute hair follicles and sebaceous glands when grafted onto mice, but epithelial cells lacking Rac1 can nonetheless form a healthy epidermis. Together, these findings support the emerging view that the epidermis and the hair follicles are maintained by different epithelial stem cells, and provide evidence that the requirement for Rac1 function can distinguish these distinct stem cells populations.Oncogene (2007) 26, 5078-5085; doi:10.1038/sj.onc.1210322; published online 5 March 2007 JF - Oncogene AU - Castilho, R M AU - Squarize, C H AU - Patel, V AU - Millar, S E AU - Zheng, Y AU - Molinolo, A AU - Gutkind, J S AD - 1 Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA Y1 - 2007/08/02/ PY - 2007 DA - 2007 Aug 02 SP - 5078 EP - 5085 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 26 IS - 35 SN - 0950-9232, 0950-9232 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Oncogenes & Growth Factors Abstracts KW - Epithelial cells KW - Skin KW - Follicles KW - Rac1 protein KW - Hair KW - Sebaceous gland KW - Epidermis KW - Stem cells KW - Gene deletion KW - Alopecia KW - Keratinocytes KW - Guanosinetriphosphatase KW - B 26610:Guanine nucleotide-binding proteins KW - G 07730:Development & Cell Cycle KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21335173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Requirement+of+Rac1+distinguishes+follicular+from+interfollicular+epithelial+stem+cells&rft.au=Castilho%2C+R+M%3BSquarize%2C+C+H%3BPatel%2C+V%3BMillar%2C+S+E%3BZheng%2C+Y%3BMolinolo%2C+A%3BGutkind%2C+J+S&rft.aulast=Castilho&rft.aufirst=R&rft.date=2007-08-02&rft.volume=26&rft.issue=35&rft.spage=5078&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/10.1038%2Fsj.onc.1210322 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Epidermis; Gene deletion; Stem cells; Skin; Follicles; Alopecia; Rac1 protein; Keratinocytes; Hair; Sebaceous gland; Guanosinetriphosphatase DO - http://dx.doi.org/10.1038/sj.onc.1210322 ER - TY - JOUR T1 - Adult mesenchymal stem cells: biological properties, characteristics, and applications in maxillofacial surgery. AN - 85395728; pmid-17656295 JF - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons AU - Shanti, Rabie M AU - Li, Wan-Ju AU - Nesti, Leon J AU - Wang, Xibin AU - Tuan, Rocky S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 1640 EP - 1647 VL - 65 IS - 8 SN - 0278-2391, 0278-2391 KW - National Library of Medicine KW - Adult Stem Cells: cytology KW - *Adult Stem Cells: physiology KW - Biocompatible Materials KW - Bone Substitutes KW - Cells, Cultured KW - Hematopoietic Stem Cells: cytology KW - Hematopoietic Stem Cells: physiology KW - Humans KW - Mesenchymal Stem Cells: cytology KW - *Mesenchymal Stem Cells: physiology KW - *Prosthesis Design: methods KW - *Reconstructive Surgical Procedures: methods KW - *Surgery, Oral: methods KW - *Tissue Engineering: methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85395728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+oral+and+maxillofacial+surgery+%3A+official+journal+of+the+American+Association+of+Oral+and+Maxillofacial+Surgeons&rft.atitle=Adult+mesenchymal+stem+cells%3A+biological+properties%2C+characteristics%2C+and+applications+in+maxillofacial+surgery.&rft.au=Shanti%2C+Rabie+M%3BLi%2C+Wan-Ju%3BNesti%2C+Leon+J%3BWang%2C+Xibin%3BTuan%2C+Rocky+S&rft.aulast=Shanti&rft.aufirst=Rabie&rft.date=2007-08-01&rft.volume=65&rft.issue=8&rft.spage=1640&rft.isbn=&rft.btitle=&rft.title=Journal+of+oral+and+maxillofacial+surgery+%3A+official+journal+of+the+American+Association+of+Oral+and+Maxillofacial+Surgeons&rft.issn=02782391&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Hemodynamic and cognitive effects of lofexidine and methadone coadministration: a pilot study. AN - 70766273; 17655511 AB - To determine the hemodynamic and cognitive effects of lofexidine and methadone coadministration. Prospective, double-blind study. Outpatient drug treatment research clinic. Fourteen participants (aged 18-45 yrs) with physical dependence on opioids. Subjects were stabilized on methadone maintenance therapy, starting with 30 mg/day and increasing by 10-mg/day increments, based on each subject's tolerability to achieve a target dose of 80 mg/day. After 3 weeks of methadone stabilization, lofexidine 0.4 mg/day or matching placebo were coadministered with methadone, in doses escalating by 0.2-mg/week increments, to achieve a target dose of 1.6 mg/day over the next 8 weeks. Acute orthostatic vital signs and neuropsychological effects of lofexidine and methadone coadministration were monitored for 5 hours after the dose on the first day of each new lofexidine dose. Orthostatic vital signs and adverse events were assessed daily thereafter to determine the effects of repeated doses. Lofexidine significantly decreased sitting systolic and diastolic blood pressure (p=0.045 and p=0.033, respectively) compared with placebo (i.e., methadone alone). With lofexidine 0.4 mg/day, mean decreases in systolic and diastolic blood pressure were 27 +/- 17 and 15 +/- 16 mm Hg, respectively. No significant association was noted between changes in orthostatic vital signs and lofexidine dose. Decreased cognitive efficiency was associated with lofexidine administration, and higher lofexidine doses adversely affected performance on a mathematical task compared with placebo (p=0.0035). The rate of adverse events was no higher with lofexidine than with placebo; the majority (54.3%) were common adverse effects of lofexidine. Significant changes in hemodynamic and cognitive efficiency were observed with coadministration of lofexidine and methadone compared with methadone alone. When patients receiving methadone are prescribed lofexidine, they should be closely monitored for cardiovascular and cognitive changes. JF - Pharmacotherapy AU - Schroeder, Jennifer R AU - Schmittner, John AU - Bleiberg, Joseph AU - Epstein, David H AU - Krantz, Mori J AU - Preston, Kenzie L AD - Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1111 EP - 1119 VL - 27 IS - 8 SN - 0277-0008, 0277-0008 KW - Narcotic Antagonists KW - 0 KW - Narcotics KW - Clonidine KW - MN3L5RMN02 KW - Methadone KW - UC6VBE7V1Z KW - lofexidine KW - UI82K0T627 KW - Index Medicus KW - Drug Interactions KW - Double-Blind Method KW - Dose-Response Relationship, Drug KW - Humans KW - Pilot Projects KW - Prospective Studies KW - Adult KW - Substance Withdrawal Syndrome -- drug therapy KW - Middle Aged KW - Blood Pressure -- drug effects KW - Adolescent KW - Female KW - Male KW - Methadone -- adverse effects KW - Clonidine -- administration & dosage KW - Clonidine -- analogs & derivatives KW - Clonidine -- adverse effects KW - Narcotics -- adverse effects KW - Narcotics -- administration & dosage KW - Methadone -- administration & dosage KW - Narcotics -- pharmacology KW - Methadone -- pharmacology KW - Narcotic Antagonists -- administration & dosage KW - Cognition -- drug effects KW - Narcotic Antagonists -- adverse effects KW - Clonidine -- pharmacology KW - Narcotic Antagonists -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70766273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Hemodynamic+and+cognitive+effects+of+lofexidine+and+methadone+coadministration%3A+a+pilot+study.&rft.au=Schroeder%2C+Jennifer+R%3BSchmittner%2C+John%3BBleiberg%2C+Joseph%3BEpstein%2C+David+H%3BKrantz%2C+Mori+J%3BPreston%2C+Kenzie+L&rft.aulast=Schroeder&rft.aufirst=Jennifer&rft.date=2007-08-01&rft.volume=27&rft.issue=8&rft.spage=1111&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-11 N1 - Date created - 2007-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sorafenib and sunitinib: novel targeted therapies for renal cell cancer. AN - 70761347; 17655513 AB - Renal cell cancer (RCC) is a relatively uncommon malignancy, with 51,190 cases expected to be diagnosed in 2007. Localized disease is curable by surgery; however, locally advanced or metastatic disease is not curable in most cases and, until recently, had a limited response to drug treatment. Historically, biologic response modifiers or immunomodulating agents were tested in clinical trials based on observations that some cases of RCC can spontaneously regress. High-dose aldesleukin is approved by the United States Food and Drug Administration as a treatment for advanced RCC; however, the drug is associated with a high frequency of severe adverse effects. Responses have been observed with low-dose aldesleukin and interferon alfa, but with little effect on overall survival. Sorafenib and sunitinib are novel therapies that target growth factor receptors known to be activated by the hypoxia-inducible factor and the Ras-Raf/MEK/ERK pathways. These pathways are important in the pathophysiology of RCC. Sorafenib and sunitinib have shown antitumor activity as first- and second-line therapy in patients with cytokine-refractory metastatic RCC who have clear-cell histology. Although complete responses are not common, both drugs promote disease stabilization and increase progression-free survival. This information suggests that disease stabilization may be an important determinant for response in RCC and possibly other cancers. Sorafenib and sunitinib are generally well tolerated and are considered first- and second-line treatment options for patients with advanced clear cell RCC. In addition, sorafenib and sunitinib have shown promising results in initial clinical trials evaluating antitumor activity in patients who are refractory to other antiangiogenic therapy. The most common toxicities with both sorafenib and sunitinib are hand-foot syndrome, rash, fatigue, hypertension, and diarrhea. Research is directed toward defining the optimal use of these new agents. JF - Pharmacotherapy AU - Grandinetti, Cheryl A AU - Goldspiel, Barry R AD - Pharmaceutical Management Branch, Cancer Therapy Evaluation Program, National Cancer Institute, Rockville, Maryland 20852, USA. grandinettic@ctep.nci.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1125 EP - 1144 VL - 27 IS - 8 SN - 0277-0008, 0277-0008 KW - Antineoplastic Agents KW - 0 KW - Benzenesulfonates KW - Indoles KW - Phenylurea Compounds KW - Pyridines KW - Pyrroles KW - Receptors, Growth Factor KW - Niacinamide KW - 25X51I8RD4 KW - sorafenib KW - 9ZOQ3TZI87 KW - sunitinib KW - V99T50803M KW - Index Medicus KW - Drug Delivery Systems KW - Drug Interactions KW - Humans KW - Niacinamide -- analogs & derivatives KW - Clinical Trials as Topic KW - Receptors, Growth Factor -- drug effects KW - Pyrroles -- adverse effects KW - Kidney Neoplasms -- drug therapy KW - Benzenesulfonates -- therapeutic use KW - Pyrroles -- pharmacokinetics KW - Pyridines -- pharmacokinetics KW - Antineoplastic Agents -- pharmacokinetics KW - Indoles -- adverse effects KW - Pyridines -- therapeutic use KW - Carcinoma, Renal Cell -- drug therapy KW - Pyrroles -- therapeutic use KW - Carcinoma, Renal Cell -- physiopathology KW - Antineoplastic Agents -- adverse effects KW - Benzenesulfonates -- adverse effects KW - Indoles -- pharmacokinetics KW - Benzenesulfonates -- pharmacokinetics KW - Indoles -- therapeutic use KW - Kidney Neoplasms -- physiopathology KW - Antineoplastic Agents -- therapeutic use KW - Pyridines -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70761347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacotherapy&rft.atitle=Sorafenib+and+sunitinib%3A+novel+targeted+therapies+for+renal+cell+cancer.&rft.au=Grandinetti%2C+Cheryl+A%3BGoldspiel%2C+Barry+R&rft.aulast=Grandinetti&rft.aufirst=Cheryl&rft.date=2007-08-01&rft.volume=27&rft.issue=8&rft.spage=1125&rft.isbn=&rft.btitle=&rft.title=Pharmacotherapy&rft.issn=02770008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-11 N1 - Date created - 2007-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cadmium-induced toxicity in rat primary mid-brain neuroglia cultures: role of oxidative stress from microglia. AN - 70761298; 17483498 AB - This study examined the role of oxidative stress in neurotoxic effects of cadmium chloride (Cd) in rat primary mid-brain neuron-glia cultures. Cd accumulated in neuron-glia cultures and produced cytotoxicity in a dose-dependent manner, with IC(50) of 2.5microM 24 h after exposure. (3)H-dopamine uptake into neuron-glia cultures was decreased 7 days after Cd exposure, with IC(50) of 0.9microM, indicative of the sensitivity of dopaminergic neurons to Cd toxicity. To investigate the role of microglia in Cd-induced toxicity to neurons, microglia-enriched cultures were prepared. Cd significantly increased intracellular reactive oxygen species production in microglia-enriched cultures, as evidenced by threefold increases in 2',7'-dichlorofluorescein signals. Using 5,5-dimethyl-1-pyrroline N-oxide as a spin-trapping agent, Cd increased electron spin resonance signals by 3.5-fold in microglia-enriched cultures. Cd-induced oxidative stress to microglia-enriched cultures was further evidenced by activation of redox-sensitive transcription factor nuclear factor kappa B and activator protein-1 (AP-1), and the increased expression of oxidative stress-related genes, such as metallothionein, heme oxygenase-1, glutathione S-transferase pi, and metal transport protein-1, as determined by gel-shift assays and real-time reverse transcription-PCR, respectively, in microglia-enriched cultures. In conclusion, Cd is toxic to neuron-glia cultures, and the oxidative stress from microglia may play important roles in Cd-induced damage to dopaminergic neurons. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Yang, Zhengqin AU - Yang, Sufen AU - Qian, Steven Y AU - Hong, Jau-Shyong AU - Kadiiska, Maria B AU - Tennant, Raymond W AU - Waalkes, Michael P AU - Liu, Jie AD - Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 488 EP - 494 VL - 98 IS - 2 SN - 1096-6080, 1096-6080 KW - Cation Transport Proteins KW - 0 KW - NF-kappa B KW - Reactive Oxygen Species KW - Transcription Factor AP-1 KW - metal transporting protein 1 KW - metallothionein 2 protein, rat KW - Cadmium KW - 00BH33GNGH KW - Metallothionein KW - 9038-94-2 KW - Heme Oxygenase-1 KW - EC 1.14.14.18 KW - Glutathione S-Transferase pi KW - EC 2.5.1.18 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Reactive Oxygen Species -- metabolism KW - Transcription Factor AP-1 -- metabolism KW - Metallothionein -- genetics KW - Heme Oxygenase-1 -- genetics KW - Mesencephalon -- cytology KW - Cation Transport Proteins -- genetics KW - Glutathione S-Transferase pi -- genetics KW - Rats KW - Rats, Inbred F344 KW - Cells, Cultured KW - NF-kappa B -- metabolism KW - Neuroglia -- metabolism KW - Oxidative Stress KW - Cadmium -- toxicity KW - Dopamine -- metabolism KW - Neuroglia -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70761298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Cadmium-induced+toxicity+in+rat+primary+mid-brain+neuroglia+cultures%3A+role+of+oxidative+stress+from+microglia.&rft.au=Yang%2C+Zhengqin%3BYang%2C+Sufen%3BQian%2C+Steven+Y%3BHong%2C+Jau-Shyong%3BKadiiska%2C+Maria+B%3BTennant%2C+Raymond+W%3BWaalkes%2C+Michael+P%3BLiu%2C+Jie&rft.aulast=Yang&rft.aufirst=Zhengqin&rft.date=2007-08-01&rft.volume=98&rft.issue=2&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-19 N1 - Date created - 2007-07-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharmacol Exp Ther. 2000 May;293(2):607-17 [10773035] Nat Rev Neurosci. 2007 Jan;8(1):57-69 [17180163] Brain Res. 2001 Feb 16;892(1):102-10 [11172754] Cell Biol Toxicol. 2000;16(6):347-62 [11254161] Int J Occup Environ Health. 2001 Apr-Jun;7(2):109-12 [11373040] Free Radic Biol Med. 2002 Mar 15;32(6):525-35 [11958953] Food Chem Toxicol. 2003 Mar;41(3):379-84 [12504170] Methods Mol Med. 2003;79:387-95 [12506711] Brain Res Mol Brain Res. 2003 Jan 31;110(1):76-84 [12573535] Br J Pharmacol. 2003 Mar;138(5):901-11 [12642392] Mutat Res. 2003 Dec 10;533(1-2):107-20 [14643415] Free Radic Biol Med. 2004 Jun 1;36(11):1434-43 [15135180] Free Radic Biol Med. 2004 Nov 1;37(9):1463-71 [15454286] J Neuropathol Exp Neurol. 1981 May;40(3):247-57 [7218003] Toxicol Appl Pharmacol. 1982 May;63(3):330-7 [7101297] Brain Res. 1986 Apr 9;370(2):354-8 [3011199] J Clin Exp Neuropsychol. 1989 Dec;11(6):933-43 [2592532] Cancer Res. 1991 Feb 1;51(3):974-8 [1988141] Arch Int Physiol Biochim. 1990 Oct;98(5):291-6 [1708997] Toxicol Appl Pharmacol. 1991 Sep 1;110(2):347-54 [1891778] Arch Toxicol. 1993;67(7):491-6 [8239998] Toxicology. 1995 Dec 15;104(1-3):141-7 [8560492] Toxicology. 1996 Sep 2;112(3):219-26 [8845042] J Neurophysiol. 1996 Nov;76(5):3264-73 [8930271] Toxicol Lett. 1996 Dec;89(1):65-9 [8952713] Free Radic Biol Med. 1997;22(3):471-8 [8981039] Clin Neurol Neurosurg. 1997 Dec;99(4):263-5 [9491302] Arch Toxicol. 1998 Nov;72(11):690-700 [9879806] Annu Rev Pharmacol Toxicol. 1999;39:267-94 [10331085] Toxicology. 1999 Mar 1;133(1):43-58 [10413193] Ann Neurol. 1999 Oct;46(4):598-605 [10514096] Toxicol Lett. 2005 Jan 15;155(1):87-96 [15585363] Int J Cancer. 2005 Apr 10;114(3):346-55 [15551354] Free Radic Biol Med. 2006 Mar 15;40(6):968-75 [16540392] J Pharmacol Exp Ther. 2006 Nov;319(2):595-603 [16891616] Brain Res. 2000 Jan 31;854(1-2):224-9 [10784126] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - ELR+-CXC chemokines and their receptors in early metanephric development. AN - 70759080; 17634442 AB - Although originally identified as mediators of inflammation, it is now apparent that chemokines play a fundamental role in tissue development. In this study, ELR(+)-CXC chemokine family members CXCL2 and CXCL7, along with their preferred receptor CXCR2, were expressed at the earliest stages of metanephric development in the rat, and signaling through this receptor was required for the survival and maintenance of the undifferentiated metanephric mesenchyme (MM). A specific antagonist of the CXCR2 receptor SB225002 induced apoptosis in this population but did not affect more mature structures or cells in the ureteric bud. CXCL7 treatment of isolated MM elicited an angiogenic response by upregulation of matrix metalloprotease 9 and endothelial and mesangial markers (platelet-endothelial cell adhesion molecule, Megsin, Thy-1, PDGF receptor alpha, and vascular alpha-actin) and induced SB225002-sensitive cell invasion through a matrix. Because Wilms' tumor cells may similarly depend on CXCR2 signaling for survival, primary tumor samples were analyzed, and 15 of 16 Wilms' tumors were found to be CXCR2 positive, whereas grossly normal kidney tissues from tumor patients or renal cell carcinomas were CXCR2 negative. Furthermore, cell lines derived from Wilms' tumors but not those from renal cell carcinomas were sensitive to SB225002-induced apoptosis. These data provide evidence for a prosurvival and proangiogenic role of ELR(+)-CXC chemokines and their receptor CXCR2 during metanephric development and suggest a novel mechanism for chemotherapeutic intervention in Wilms' tumor. JF - Journal of the American Society of Nephrology : JASN AU - Levashova, Zoia B AU - Sharma, Nirmala AU - Timofeeva, Olga A AU - Dome, Jeffrey S AU - Perantoni, Alan O AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute, National Institutes of Health, Frederick, MD 21702-1201, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 2359 EP - 2370 VL - 18 IS - 8 SN - 1046-6673, 1046-6673 KW - Chemokine CXCL1 KW - 0 KW - Chemokine CXCL2 KW - Chemokines, CXC KW - Cxcl1 protein, rat KW - Cxcl2 protein, rat KW - Cxcl7 protein, rat KW - Receptors, Interleukin-8A KW - Receptors, Interleukin-8B KW - Index Medicus KW - Animals KW - Oligonucleotide Array Sequence Analysis KW - Pregnancy KW - Rats KW - Signal Transduction -- physiology KW - Gene Expression Profiling KW - Rats, Inbred F344 KW - Cell Differentiation -- physiology KW - Kidney Neoplasms -- physiopathology KW - Cell Line KW - Cell Survival -- physiology KW - Female KW - Gene Expression Regulation, Developmental KW - Neovascularization, Physiologic -- physiology KW - Receptors, Interleukin-8A -- genetics KW - Chemokines, CXC -- metabolism KW - Receptors, Interleukin-8A -- metabolism KW - Receptors, Interleukin-8B -- genetics KW - Kidney -- embryology KW - Kidney -- physiology KW - Kidney -- cytology KW - Chemokines, CXC -- genetics KW - Receptors, Interleukin-8B -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70759080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.atitle=ELR%2B-CXC+chemokines+and+their+receptors+in+early+metanephric+development.&rft.au=Levashova%2C+Zoia+B%3BSharma%2C+Nirmala%3BTimofeeva%2C+Olga+A%3BDome%2C+Jeffrey+S%3BPerantoni%2C+Alan+O&rft.aulast=Levashova&rft.aufirst=Zoia&rft.date=2007-08-01&rft.volume=18&rft.issue=8&rft.spage=2359&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+of+Nephrology+%3A+JASN&rft.issn=10466673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-26 N1 - Date created - 2007-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Darunavir: a second-generation protease inhibitor. AN - 70756461; 17646561 AB - The pharmacology, pharmacokinetics, drug interactions, clinical efficacy, adverse events, dosage and administration, and place in therapy of darunavir are reviewed. Darunavir is the most recent protease inhibitor (PI) to receive approved labeling from the Food and Drug Administration for the treatment of human immunodeficiency virus (HIV). Darunavir is unique among currently available PIs because it maintains antiretroviral activity against a variety of multidrug-resistant HIV strains. Darunavir is well absorbed, and the bioavailability of darunavir increases by 30% when given with food. Darunavir is approximately 95% bound to plasma proteins. Darunavir is metabolized by and inhibits cytochrome P-450 (CYP) isoenzyme 3A4; therefore, darunavir is prone to CYP3A4-mediated drug-drug interactions. Two trials have demonstrated the clinical efficacy of darunavir in HIV-positive patients previously treated with antiretrovirals. One trial demonstrated a 2 log(10) decrease in plasma HIV RNA levels, compared with a decrease of <1 log(10) in the control group. Average increases in CD4+ T-cell counts for darunavir and control groups were 124 and 20 cells/mm(3), respectively. Adverse events reported from preliminary safety data indicate that darunavir has a similar safety profile to other currently available PIs. The recommended adult dosage of darunavir is 600 mg (two tablets) combined with ritonavir 100 mg every 12 hours with food. Darunavir should be used with caution in patients with hepatic dysfunction. No dosage adjustment is necessary for patients with mild or moderate renal dysfunction. Darunavir is a new HIV PI that retains virological activity in the presence of multiple protease mutations. As such, darunavir appears to be a useful component of optimized combination antiretroviral therapy for HIV-infected patients previously treated with antiretrovirals. JF - American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists AU - Busse, Kristin H S AU - Penzak, Scott R AD - Pharmacy Department, Clinical Center, National Institutes of Health, Bethesda, MD 20896-1196, USA. bussek@mail.nih.gov Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 1593 EP - 1602 VL - 64 IS - 15 KW - HIV Protease Inhibitors KW - 0 KW - Sulfonamides KW - Darunavir KW - YO603Y8113 KW - Index Medicus KW - Animals KW - Drug Resistance, Viral KW - Humans KW - Clinical Trials as Topic KW - Sulfonamides -- pharmacokinetics KW - Sulfonamides -- adverse effects KW - Sulfonamides -- pharmacology KW - HIV Infections -- drug therapy KW - HIV Protease Inhibitors -- pharmacology KW - HIV Protease Inhibitors -- pharmacokinetics KW - HIV Protease Inhibitors -- therapeutic use KW - HIV Protease Inhibitors -- adverse effects KW - Sulfonamides -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70756461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.atitle=Darunavir%3A+a+second-generation+protease+inhibitor.&rft.au=Busse%2C+Kristin+H+S%3BPenzak%2C+Scott+R&rft.aulast=Busse&rft.aufirst=Kristin+H&rft.date=2007-08-01&rft.volume=64&rft.issue=15&rft.spage=1593&rft.isbn=&rft.btitle=&rft.title=American+journal+of+health-system+pharmacy+%3A+AJHP+%3A+official+journal+of+the+American+Society+of+Health-System+Pharmacists&rft.issn=1535-2900&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-21 N1 - Date created - 2007-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pathways to smoking cessation among African American and Puerto Rican young adults. AN - 70751821; 17600250 AB - We examined the pathways to smoking cessation between late adolescence and young adulthood. We obtained data from a sample of urban African American and Puerto Rican young adults (N=242), mean age 19 years, who reported tobacco use and determined cessation rates between late adolescence and young adulthood. We used structural equation modeling to examine the pathways of positive family relations, family smoking, maladaptive personality attributes, and substance use to smoking cessation. A mediational pathway linked the absence of positive family relations with maladaptive personality attributes, both of which were related to substance use and ultimately smoking cessation. Substance use mediated the path between family smoking and smoking cessation. The results suggest that a positive relationship with one's parents, less smoking in the family, conventional personality attributes, and little or no other substance use facilitate smoking cessation among young adults. JF - American journal of public health AU - Marcus, Stephen E AU - Pahl, Kerstin AU - Ning, Yuming AU - Brook, Judith S AD - National Cancer Institute, Washington, DC, USA. marcusst@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1444 EP - 1448 VL - 97 IS - 8 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Puerto Rico -- ethnology KW - Personality KW - Parent-Child Relations KW - Longitudinal Studies KW - Comorbidity KW - Factor Analysis, Statistical KW - New York City -- epidemiology KW - Risk Factors KW - Adult KW - Female KW - Male KW - Substance-Related Disorders -- epidemiology KW - Smoking Cessation -- psychology KW - Models, Psychological KW - Hispanic Americans -- statistics & numerical data KW - African Americans -- psychology KW - African Americans -- statistics & numerical data KW - Smoking Cessation -- methods KW - Hispanic Americans -- psychology KW - Smoking Cessation -- ethnology KW - Family Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70751821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+public+health&rft.atitle=Pathways+to+smoking+cessation+among+African+American+and+Puerto+Rican+young+adults.&rft.au=Marcus%2C+Stephen+E%3BPahl%2C+Kerstin%3BNing%2C+Yuming%3BBrook%2C+Judith+S&rft.aulast=Marcus&rft.aufirst=Stephen&rft.date=2007-08-01&rft.volume=97&rft.issue=8&rft.spage=1444&rft.isbn=&rft.btitle=&rft.title=American+journal+of+public+health&rft.issn=1541-0048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-20 N1 - Date created - 2007-07-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Addict Behav. 1999 Sep-Oct;24(5):673-7 [10574304] Addict Behav. 2006 May;31(5):788-801 [15993005] Nicotine Tob Res. 1999;1 Suppl 2:S51-7; discussion S69-70 [11768187] J Consult Clin Psychol. 2001 Dec;69(6):959-70 [11777123] Addict Behav. 2002 Mar-Apr;27(2):193-206 [11817762] Am J Health Promot. 2002 May-Jun;16(5):259-66 [12053437] Addiction. 2002 Jul;97(7):861-9 [12133125] Addiction. 2002 Dec;97(12):1537-50 [12472638] Nicotine Tob Res. 2003 Feb;5(1):85-98 [12745510] BMJ. 2004 Jun 26;328(7455):1519 [15213107] Behav Sci. 1974 Jan;19(1):1-15 [4808738] Am J Drug Alcohol Abuse. 1987;13(1-2):95-108 [3687887] Genet Soc Gen Psychol Monogr. 1990 May;116(2):111-267 [2376323] Prev Med. 1994 Jan;23(1):48-53 [8016032] Am J Public Health. 1996 Feb;86(2):214-20 [8633738] Addict Behav. 1996 May-Jun;21(3):291-302 [8883481] J Adolesc Health. 1997 Mar;20(3):226-31 [9069023] J Genet Psychol. 1997 Jun;158(2):172-88 [9168587] J Pers Soc Psychol. 1998 Feb;74(2):387-406 [9491584] Prev Med. 1998 May-Jun;27(3):365-84 [9612827] Am J Prev Med. 1999 Apr;16(3):202-7 [10198659] Addict Behav. 2005 Mar;30(3):517-29 [15718068] MMWR Morb Mortal Wkly Rep. 2005 Jul 1;54(25):625-8 [15988406] MMWR Morb Mortal Wkly Rep. 2005 Nov 11;54(44):1121-4 [16280969] Arch Gen Psychiatry. 2001 Sep;58(9):810-6 [11545662] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gemcitabine-based combinations for inoperable pancreatic cancer: have we made real progress? A meta-analysis of 20 phase 3 trials. AN - 70747759; 17577216 AB - Several attempts have been made at improving the efficacy of gemcitabine in advanced pancreatic cancer by combining it with other chemotherapeutic or molecularly targeted agents. However, randomized trials have produced conflicting results. All prospective, randomized, phase 3 trials that compared single-agent gemcitabine with gemcitabine-based combinations were considered eligible for the current analysis. A literature-based meta-analysis was performed, event-based relative risk ratios with 95% confidence intervals were derived through both a fixed-effect model approach and a random-effect model approach, and overall survival (OS) was explored as the primary endpoint. To estimate the magnitude of the eventual benefit, absolute differences and the number of patients needed to treat (NNT) for 1 patient to benefit were calculated. A sensitivity analysis for OS was performed according to the type of agent used in combination with gemcitabine. Twenty trials that involved 6,296 patients were identified. No significant differences in the primary endpoint were observed in the overall population or in the sensitivity analysis. Conversely, a significant advantage was evident with regard to both progression-free survival (PFS) and the overall response rate (ORR) in the overall population, with an absolute benefit of 2.6% (NTT = 39 patients) and 3.0% (NNT = 33 patients). Platinum combinations led to the greatest absolute benefits for PFS and ORR compared with single-agent gemcitabine (10% and 6.5%, respectively), but this did not result in an OS benefit. Improvement in PFS, but not in the ORR, was correlated with an improvement in OS. Single-agent gemcitabine remains the standard of care for patients with advanced pancreatic cancer. However, platinum/gemcitabine combinations appeared to improve PFS and the ORR and, thus, may be considered in selected patients. (c) 2007 American Cancer Society. JF - Cancer AU - Bria, Emilio AU - Milella, Michele AU - Gelibter, Alain AU - Cuppone, Federica AU - Pino, Maria Simona AU - Ruggeri, Enzo Maria AU - Carlini, Paolo AU - Nisticò, Cecilia AU - Terzoli, Edmondo AU - Cognetti, Francesco AU - Giannarelli, Diana AD - Department of Medical Oncology, Regina Elena National Cancer Institute, Rome, Italy. Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 525 EP - 533 VL - 110 IS - 3 SN - 0008-543X, 0008-543X KW - Antimetabolites, Antineoplastic KW - 0 KW - Deoxycytidine KW - 0W860991D6 KW - gemcitabine KW - B76N6SBZ8R KW - Abridged Index Medicus KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Prospective Studies KW - Survival Rate KW - Dose-Response Relationship, Drug KW - Clinical Trials, Phase III as Topic KW - Humans KW - Treatment Outcome KW - Disease Progression KW - Deoxycytidine -- analogs & derivatives KW - Deoxycytidine -- therapeutic use KW - Pancreatic Neoplasms -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Antimetabolites, Antineoplastic -- therapeutic use KW - Pancreatic Neoplasms -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70747759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Gemcitabine-based+combinations+for+inoperable+pancreatic+cancer%3A+have+we+made+real+progress%3F+A+meta-analysis+of+20+phase+3+trials.&rft.au=Bria%2C+Emilio%3BMilella%2C+Michele%3BGelibter%2C+Alain%3BCuppone%2C+Federica%3BPino%2C+Maria+Simona%3BRuggeri%2C+Enzo+Maria%3BCarlini%2C+Paolo%3BNistic%C3%B2%2C+Cecilia%3BTerzoli%2C+Edmondo%3BCognetti%2C+Francesco%3BGiannarelli%2C+Diana&rft.aulast=Bria&rft.aufirst=Emilio&rft.date=2007-08-01&rft.volume=110&rft.issue=3&rft.spage=525&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-06 N1 - Date created - 2007-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intersectin enhances huntingtin aggregation and neurodegeneration through activation of c-Jun-NH2-terminal kinase. AN - 70745663; 17550941 AB - Huntingon's disease is a progressive neurodegenerative disease arising from expansion of a polyglutamine (polyQ) tract in the protein huntingtin (Htt) resulting in aggregation of mutant Htt into nuclear and/or cytosolic inclusions in neurons. Mutant Htt affects multiple processes including protein degradation, transcription, signal transduction, fast axonal transport and endocytosis [reviewed in Ross, C.A. and Poirier, M.A. (2005) Opinion: what is the role of protein aggregation in neurodegeneration? Nat. Rev. Mol. Cell. Biol., 6, 891-898]. Here, we report that the endocytic and signal transduction scaffold intersectin (ITSN) increased aggregate formation by mutant Htt through activation of the c-Jun-NH(2)-terminal kinase (JNK)-MAPK pathway. Conversely, silencing ITSN or inhibiting JNK attenuated aggregate formation. Using a Drosophila model for polyQ repeat disease, we observed that ITSN enhanced polyQ-mediated neurotoxicity. A reciprocal relationship was observed between ITSN and Htt. While ITSN enhanced Htt aggregation and toxicity, Htt, in turn, inhibited the cooperativity between ITSN and the epidermal growth factor receptor signal transduction pathway. Finally, we observed that ITSN overexpression enhanced aggregation of polyQ-expanded androgen receptor (AR) as well as wild-type versions of both Htt and AR suggesting a broader involvement of ITSN in neurodegenerative diseases through destabilization of polyQ-containing proteins. JF - Human molecular genetics AU - Scappini, Erica AU - Koh, Tong-Wey AU - Martin, Negin P AU - O'Bryan, John P AD - Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 1862 EP - 1871 VL - 16 IS - 15 SN - 0964-6906, 0964-6906 KW - Adaptor Proteins, Vesicular Transport KW - 0 KW - HTT protein, human KW - Huntingtin Protein KW - Nerve Tissue Proteins KW - Nuclear Proteins KW - Peptides KW - Recombinant Fusion Proteins KW - intersectin 1 KW - polyglutamine KW - 26700-71-0 KW - JNK Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Microscopy, Confocal KW - Animals KW - Neurons -- metabolism KW - COS Cells KW - Enzyme Activation KW - Humans KW - Drosophila -- metabolism KW - Peptides -- metabolism KW - Mice KW - Recombinant Fusion Proteins -- metabolism KW - Cells, Cultured KW - Cercopithecus aethiops KW - Recombinant Fusion Proteins -- genetics KW - Drosophila -- genetics KW - Mutation KW - Signal Transduction KW - Nuclear Proteins -- analysis KW - Nerve Tissue Proteins -- analysis KW - Huntington Disease -- metabolism KW - Adaptor Proteins, Vesicular Transport -- metabolism KW - Nerve Tissue Proteins -- metabolism KW - Nuclear Proteins -- metabolism KW - JNK Mitogen-Activated Protein Kinases -- metabolism KW - Huntington Disease -- enzymology KW - Adaptor Proteins, Vesicular Transport -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70745663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+molecular+genetics&rft.atitle=Intersectin+enhances+huntingtin+aggregation+and+neurodegeneration+through+activation+of+c-Jun-NH2-terminal+kinase.&rft.au=Scappini%2C+Erica%3BKoh%2C+Tong-Wey%3BMartin%2C+Negin+P%3BO%27Bryan%2C+John+P&rft.aulast=Scappini&rft.aufirst=Erica&rft.date=2007-08-01&rft.volume=16&rft.issue=15&rft.spage=1862&rft.isbn=&rft.btitle=&rft.title=Human+molecular+genetics&rft.issn=09646906&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-18 N1 - Date created - 2007-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - CLIC4 mediates and is required for Ca2+-induced keratinocyte differentiation. AN - 70744835; 17636002 AB - Keratinocyte differentiation requires integrating signaling among intracellular ionic changes, kinase cascades, sequential gene expression, cell cycle arrest, and programmed cell death. We now show that Cl(-) intracellular channel 4 (CLIC4) expression is increased in both mouse and human keratinocytes undergoing differentiation induced by Ca(2+), serum and the protein kinase C (PKC)-activator, 12-O-tetradecanoyl-phorbol-13-acetate (TPA). Elevation of CLIC4 is associated with signaling by PKCdelta, and knockdown of CLIC4 protein by antisense or shRNA prevents Ca(2+)-induced keratin 1, keratin 10 and filaggrin expression and cell cycle arrest in differentiating keratinocytes. CLIC4 is cytoplasmic in actively proliferating keratinocytes in vitro, but the cytoplasmic CLIC4 translocates to the nucleus in keratinocytes undergoing growth arrest by differentiation, senescence or transforming growth factor beta (TGFbeta) treatment. Targeting CLIC4 to the nucleus of keratinocytes via adenoviral transduction increases nuclear Cl(-) content and enhances expression of differentiation markers in the absence of elevated Ca(2+). In vivo, CLIC4 is localized to the epidermis in mouse and human skin, where it is predominantly nuclear in quiescent cells. These results suggest that CLIC4 participates in epidermal homeostasis through both alterations in the level of expression and subcellular localization. Nuclear CLIC4, possibly by altering the Cl(-) and pH of the nucleus, contributes to cell cycle arrest and the specific gene expression program associated with keratinocyte terminal differentiation. JF - Journal of cell science AU - Suh, Kwang S AU - Mutoh, Michihiro AU - Mutoh, Tomoko AU - Li, Luowei AU - Ryscavage, Andrew AU - Crutchley, John M AU - Dumont, Rebecca A AU - Cheng, Christina AU - Yuspa, Stuart H AD - Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 2631 EP - 2640 VL - 120 SN - 0021-9533, 0021-9533 KW - CLIC4 protein, human KW - 0 KW - Chloride Channels KW - Intermediate Filament Proteins KW - Protein Isoforms KW - Transcription Factor AP-1 KW - filaggrin KW - Keratins KW - 68238-35-7 KW - Protein Kinase C KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Keratins -- metabolism KW - Animals KW - Transcription Factor AP-1 -- metabolism KW - Cells, Cultured KW - Cell Nucleus -- metabolism KW - Protein Isoforms -- metabolism KW - Humans KW - Gene Expression KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Mice KW - Intermediate Filament Proteins -- metabolism KW - Protein Kinase C -- metabolism KW - Calcium -- metabolism KW - Chloride Channels -- isolation & purification KW - Keratinocytes -- cytology KW - Chloride Channels -- metabolism KW - Cell Differentiation KW - Keratinocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70744835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cell+science&rft.atitle=CLIC4+mediates+and+is+required+for+Ca2%2B-induced+keratinocyte+differentiation.&rft.au=Suh%2C+Kwang+S%3BMutoh%2C+Michihiro%3BMutoh%2C+Tomoko%3BLi%2C+Luowei%3BRyscavage%2C+Andrew%3BCrutchley%2C+John+M%3BDumont%2C+Rebecca+A%3BCheng%2C+Christina%3BYuspa%2C+Stuart+H&rft.aulast=Suh&rft.aufirst=Kwang&rft.date=2007-08-01&rft.volume=120&rft.issue=&rft.spage=2631&rft.isbn=&rft.btitle=&rft.title=Journal+of+cell+science&rft.issn=00219533&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-06 N1 - Date created - 2007-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The anesthetic management of children with neonatal-onset multi-system inflammatory disease. AN - 70741850; 17646489 AB - Neonatal-onset multi-system inflammatory disease (NOMID), a rare autosomal dominantly inherited disease, belongs to a growing spectrum of autoinflammatory diseases, is characterized by urticarial rash, arthropathy, and chronic aseptic meningitis, and is associated with mutations in the cold-induced autoinflammatory gene, CIAS1, the gene that encodes the protein, cryopyrin. As little is known about the anesthetic considerations of the disease, we sought to identify the main features and respective anesthetic and perioperative implications of NOMID. We examined perianesthetic records of children with NOMID who were anesthetized for invasive diagnostic and therapeutic interventions between 2003 and 2006. In addition, we conducted an extensive literature review of the genetic, clinical, and biochemical abnormalities of the disease. Seventeen children with NOMID (median age 8 yr, range 9 mo to 11 yr) were anesthetized for diagnostic and therapeutic procedures. All patients had neurological involvement, including increased intracranial pressure, chronic aseptic meningitis, and developmental delay; 7 had bony overgrowth, 15 ocular, and 14 otological manifestations of NOMID. Despite the complexity of the disease, the perioperative course was uncomplicated, and no serious adverse events were observed. This study is the first to investigate the anesthetic implications of NOMID, an autoinflammatory disease associated with arthropathy, recurrent fevers, urticarial rash, and chronic aseptic meningitis. While for the pediatric anesthesiologist, the presence of fever and aseptic meningitis might make the conduct of anesthetics for elective procedures less desirable, our findings suggest that without evidence of active infection, even in the presence of fever and chronic aseptic meningitis, general and regional anesthesia may be conducted in patients with NOMID without untoward complications. JF - Anesthesia and analgesia AU - Lauro, Christine F AU - Goldbach-Mansky, Raphaela AU - Schmidt, Margaret AU - Quezado, Zenaide M N AD - Department of Anesthesia and Surgical Services, National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD 20892-1512, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 351 EP - 357 VL - 105 IS - 2 KW - Anesthetics KW - 0 KW - Carrier Proteins KW - NLR Family, Pyrin Domain-Containing 3 Protein KW - NLRP3 protein, human KW - Abridged Index Medicus KW - Index Medicus KW - Infant KW - Inflammation -- therapy KW - Inflammation -- physiopathology KW - Humans KW - Disease Management KW - Carrier Proteins -- genetics KW - Inflammation -- genetics KW - Child KW - Male KW - Female KW - Child, Preschool KW - Autoimmune Diseases of the Nervous System -- physiopathology KW - Anesthetics -- therapeutic use KW - Anesthetics -- adverse effects KW - Autoimmune Diseases of the Nervous System -- therapy KW - Autoimmune Diseases of the Nervous System -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70741850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesia+and+analgesia&rft.atitle=The+anesthetic+management+of+children+with+neonatal-onset+multi-system+inflammatory+disease.&rft.au=Lauro%2C+Christine+F%3BGoldbach-Mansky%2C+Raphaela%3BSchmidt%2C+Margaret%3BQuezado%2C+Zenaide+M+N&rft.aulast=Lauro&rft.aufirst=Christine&rft.date=2007-08-01&rft.volume=105&rft.issue=2&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=Anesthesia+and+analgesia&rft.issn=1526-7598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-20 N1 - Date created - 2007-07-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arthritis Rheum. 2005 Apr;52(4):1283-6 [15818707] Clin Ther. 2004 Dec;26(12):1960-75 [15823761] Arch Dermatol. 2005 Feb;141(2):248-53 [15724022] Immunobiology. 1990 Jun;180(4-5):316-27 [2168857] J Clin Invest. 1990 May;85(5):1694-7 [2139669] Scand J Rheumatol Suppl. 1987;66:57-68 [3482735] Pediatrics. 2004 Jul;114(1):e124-7 [15231984] Blood. 2004 Apr 1;103(7):2809-15 [14630794] Immunity. 2004 Mar;20(3):319-25 [15030775] Eur J Haematol. 2003 Sep;71(3):215-9 [12930324] Curr Opin Rheumatol. 2003 Jan;15(1):61-9 [12496512] Arthritis Rheum. 2002 Dec;46(12):3340-8 [12483741] Acta Neurochir Suppl. 2002;81:89-91 [12168367] Am J Hum Genet. 2002 Jul;71(1):198-203 [12032915] Clin Exp Rheumatol. 2001 Jan-Feb;19(1):103-6 [11247311] Nat Rev Immunol. 2007 Jan;7(1):31-40 [17186029] N Engl J Med. 2006 Aug 10;355(6):581-92 [16899778] Reg Anesth Pain Med. 2006 Jul-Aug;31(4):334-45 [16857553] Reg Anesth Pain Med. 2006 Jul-Aug;31(4):324-33 [16857552] Am J Med Genet A. 2006 Apr 15;140(8):883-6 [16532456] Nature. 2006 Mar 9;440(7081):228-32 [16407890] Paediatr Anaesth. 2005 Dec;15(12):1078-82 [16324027] Scand J Rheumatol. 2005 May-Jun;34(3):246-9 [16134734] Curr Opin Rheumatol. 2005 Sep;17(5):586-99 [16093838] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reporting data from high-throughput screening of small-molecule libraries. AN - 70736539; 17637769 AB - Publications reporting results of small-molecule screens are becoming more common as academic researchers increasingly make use of high-throughput screening (HTS) facilities. However, no standards have been formally established for reporting small-molecule screening data, and often key information important for the evaluation and interpretation of results is omitted in published HTS protocols. Here, we propose concise guidelines for reporting small-molecule HTS data. JF - Nature chemical biology AU - Inglese, James AU - Shamu, Caroline E AU - Guy, R Kiplin AD - US National Institutes of Health Chemical Genomics Center, National Human Genome Institute, National Institutes of Health, 9800 Medical Center Drive, Bethesda, Maryland 20892-3370, USA. jinglese@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 438 EP - 441 VL - 3 IS - 8 SN - 1552-4450, 1552-4450 KW - Pharmaceutical Preparations KW - 0 KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Models, Chemical KW - Guidelines as Topic KW - Molecular Conformation KW - Inhibitory Concentration 50 KW - Drug Evaluation, Preclinical KW - Drug Design KW - Technology, Pharmaceutical -- methods KW - Combinatorial Chemistry Techniques KW - Chemistry, Pharmaceutical -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70736539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+chemical+biology&rft.atitle=Reporting+data+from+high-throughput+screening+of+small-molecule+libraries.&rft.au=Inglese%2C+James%3BShamu%2C+Caroline+E%3BGuy%2C+R+Kiplin&rft.aulast=Inglese&rft.aufirst=James&rft.date=2007-08-01&rft.volume=3&rft.issue=8&rft.spage=438&rft.isbn=&rft.btitle=&rft.title=Nature+chemical+biology&rft.issn=15524450&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-06 N1 - Date created - 2007-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification of two distinct human immunodeficiency virus type 1 Vif determinants critical for interactions with human APOBEC3G and APOBEC3F. AN - 70726759; 17522216 AB - Human cytidine deaminases APOBEC3G (A3G) and APOBEC3F (A3F) inhibit replication of Vif-deficient human immunodeficiency virus type 1 (HIV-1). HIV-1 Vif overcomes these host restriction factors by binding to them and inducing their proteasomal degradation. The Vif-A3G and Vif-A3F interactions are attractive targets for antiviral drug development because inhibiting the interactions could allow the host defense mechanism to control HIV-1 replication. It was recently reported that the Vif amino acids D(14)RMR(17) are important for functional interaction and degradation of the previously identified Vif-resistant mutant of A3G (D128K-A3G). However, the Vif determinants important for functional interaction with A3G and A3F have not been fully characterized. To identify these determinants, we performed an extensive mutational analysis of HIV-1 Vif. Our analysis revealed two distinct Vif determinants, amino acids Y(40)RHHY(44) and D(14)RMR(17), which are essential for binding to A3G and A3F, respectively. Interestingly, mutation of the A3G-binding region increased Vif's ability to suppress A3F. Vif binding to D128K-A3G was also dependent on the Y(40)RHHY(44) region but not the D(14)RMR(17) region. Consistent with previous observations, subsequent neutralization of the D128K-A3G antiviral activity required substitution of Vif determinant D(14)RMR(17) with SEMQ, similar to the SERQ amino acids in simian immunodeficiency virus SIV(AGM) Vif, which is capable of neutralizing D128K-A3G. These studies are the first to clearly identify two distinct regions of Vif that are critical for independent interactions with A3G and A3F. Pharmacological interference with the Vif-A3G or Vif-A3F interactions could result in potent inhibition of HIV-1 replication by the APOBEC3 proteins. JF - Journal of virology AU - Russell, Rebecca A AU - Pathak, Vinay K AD - HIV Drug Resistance Program, National Cancer Institute-Frederick, P.O. Box B, Bldg. 535, Rm. 334, Frederick, MD 21702-1201, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 8201 EP - 8210 VL - 81 IS - 15 SN - 0022-538X, 0022-538X KW - Gene Products, vif KW - 0 KW - Repressor Proteins KW - vif Gene Products, Human Immunodeficiency Virus KW - Nucleoside Deaminases KW - EC 3.5.4.- KW - APOBEC3F protein, human KW - EC 3.5.4.1 KW - Cytosine Deaminase KW - APOBEC-3G Deaminase KW - EC 3.5.4.5 KW - APOBEC3G protein, human KW - Cytidine Deaminase KW - Alanine KW - OF5P57N2ZX KW - Index Medicus KW - Alanine -- metabolism KW - Humans KW - DNA Mutational Analysis KW - Protein Binding KW - Cell Line KW - Mutagenesis KW - Nucleoside Deaminases -- genetics KW - HIV-1 -- metabolism KW - Nucleoside Deaminases -- antagonists & inhibitors KW - Gene Products, vif -- chemistry KW - Cytosine Deaminase -- antagonists & inhibitors KW - Repressor Proteins -- metabolism KW - Nucleoside Deaminases -- metabolism KW - Cytosine Deaminase -- genetics KW - Gene Products, vif -- metabolism KW - Cytosine Deaminase -- metabolism KW - Gene Products, vif -- genetics KW - Repressor Proteins -- genetics KW - Repressor Proteins -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70726759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Identification+of+two+distinct+human+immunodeficiency+virus+type+1+Vif+determinants+critical+for+interactions+with+human+APOBEC3G+and+APOBEC3F.&rft.au=Russell%2C+Rebecca+A%3BPathak%2C+Vinay+K&rft.aulast=Russell&rft.aufirst=Rebecca&rft.date=2007-08-01&rft.volume=81&rft.issue=15&rft.spage=8201&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-26 N1 - Date created - 2007-07-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3927-32 [14978281] Virology. 2007 Apr 10;360(2):247-56 [17126871] J Biol Chem. 2004 Apr 9;279(15):14481-3 [14966139] Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5652-7 [15054139] EMBO J. 2004 Jun 16;23(12):2451-8 [15152192] Curr Biol. 2004 Aug 10;14(15):1385-91 [15296757] J Biol Chem. 2004 Aug 20;279(34):35822-8 [15210704] Nature. 1987 Aug 20-26;328(6132):728-30 [2441266] J Virol. 1992 Nov;66(11):6489-95 [1357189] J Virol. 1993 Aug;67(8):4945-55 [8331734] J Virol. 1994 Feb;68(2):704-12 [8289374] Methods Cell Biol. 1994;43 Pt A:99-112 [7823872] J Virol. 1998 Dec;72(12):10251-5 [9811770] Nat Med. 1998 Dec;4(12):1397-400 [9846577] Hum Gene Ther. 1999 Jan 1;10(1):123-32 [10022537] J Virol. 2000 Sep;74(18):8358-67 [10954535] Antimicrob Agents Chemother. 2002 Jun;46(6):1896-905 [12019106] Nature. 2002 Aug 8;418(6898):646-50 [12167863] J Virol. 2003 Jan;77(2):1626-32 [12502880] Science. 2003 May 16;300(5622):1112 [12750511] Cell. 2003 Jun 13;113(6):803-9 [12809610] Nature. 2003 Jul 3;424(6944):94-8 [12808465] Nature. 2003 Jul 3;424(6944):99-103 [12808466] Mol Cell. 2003 Sep;12(3):591-601 [14527406] J Virol. 2003 Nov;77(21):11398-407 [14557625] Nat Med. 2003 Nov;9(11):1404-7 [14528300] Nat Med. 2003 Nov;9(11):1398-403 [14528301] Science. 2003 Nov 7;302(5647):1056-60 [14564014] Curr Biol. 2003 Nov 11;13(22):2009-13 [14614829] J Virol. 2004 Feb;78(4):2072-81 [14747572] J Biol Chem. 2004 Feb 27;279(9):7792-8 [14672928] Virology. 2004 Feb 20;319(2):163-75 [15015498] J Virol. 1999 Apr;73(4):2675-81 [10074113] J Exp Med. 1999 Jun 7;189(11):1735-46 [10359577] Biochem Biophys Res Commun. 2005 Apr 15;329(3):917-24 [15752743] J Biol Chem. 2005 May 13;280(19):18573-8 [15781449] Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11444-9 [16076960] J Virol. 2006 Mar;80(6):3112-5 [16501124] Virology. 2006 May 25;349(1):31-40 [16460778] J Virol. 2006 Jun;80(12):5984-91 [16731937] FASEB J. 2007 Jan;21(1):217-22 [17135358] Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3770-4 [14999100] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Arachidonic acid metabolism in brain physiology and pathology: lessons from genetically altered mouse models. AN - 70723752; 17403135 AB - The arachidonic acid (AA) cascade involves the release of AA from the membrane phospholipids by a phospholipase A(2), followed by its subsequent metabolism to bioactive prostanoids by cyclooxygenases coupled with terminal synthases. Altered brain AA metabolism has been implicated in neurological, neurodegenerative, and psychiatric disorders. The development of genetically altered mice lacking specific enzymes of the AA cascade has helped to elucidate the individual roles of these enzymes in brain physiology and pathology. The roles of AA and its metabolites in brain physiology, with a particular emphasis on the phospholipase A(2)/cyclooxygenases pathway, are summarized, and the specific phenotypes of genetically altered mice relevant to brain physiology and neurotoxic models are discussed. JF - Journal of neurochemistry AU - Bosetti, Francesca AD - Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA. frances@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 577 EP - 586 VL - 102 IS - 3 SN - 0022-3042, 0022-3042 KW - Prostaglandins KW - 0 KW - Arachidonic Acid KW - 27YG812J1I KW - Prostaglandin-Endoperoxide Synthases KW - EC 1.14.99.1 KW - Phospholipases A KW - EC 3.1.1.32 KW - Index Medicus KW - Animals KW - Mice, Knockout -- genetics KW - Brain Diseases -- genetics KW - Prostaglandins -- biosynthesis KW - Mice, Knockout -- metabolism KW - Mice KW - Brain Diseases -- physiopathology KW - Models, Biological KW - Brain Diseases -- metabolism KW - Brain -- physiopathology KW - Prostaglandin-Endoperoxide Synthases -- metabolism KW - Brain -- metabolism KW - Arachidonic Acid -- metabolism KW - Phospholipases A -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70723752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Arachidonic+acid+metabolism+in+brain+physiology+and+pathology%3A+lessons+from+genetically+altered+mouse+models.&rft.au=Bosetti%2C+Francesca&rft.aulast=Bosetti&rft.aufirst=Francesca&rft.date=2007-08-01&rft.volume=102&rft.issue=3&rft.spage=577&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-15 N1 - Date created - 2007-07-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Brain Res. 2003 Jan 10;959(2):328-35 [12493622] J Lipid Res. 2003 Jan;44(1):109-17 [12518029] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4132-7 [12642666] J Neurochem. 2003 May;85(3):690-6 [12694395] Comp Med. 2004 Oct;54(5):497-513 [15575363] J Neurochem. 2004 Dec;91(6):1389-97 [15584915] Brain Res. 2005 Mar 10;1037(1-2):180-6 [15777767] Ann Neurol. 2005 May;57(5):758-61 [15852374] Am J Physiol Regul Integr Comp Physiol. 2005 Jun;288(6):R1774-82 [15718387] J Neuroimmunol. 2005 Sep;166(1-2):55-64 [16019083] Glia. 2005 Oct;52(1):70-7 [15920732] J Neurochem. 2005 Sep;94(6):1546-58 [16000148] Brain Res Mol Brain Res. 2005 Oct 3;139(2):217-24 [16055227] Am J Pathol. 2005 Nov;167(5):1371-7 [16251421] Eur J Neurosci. 2005 Nov;22(9):2199-206 [16262658] Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16066-71 [16247016] Ann Neurol. 2001 Feb;49(2):176-85 [11220737] J Neurochem. 2005 Dec;95(6):1563-74 [16277613] J Neurochem. 2006 Feb;96(3):669-79 [16405503] Nat Med. 2006 Feb;12(2):225-9 [16432513] Mol Nutr Food Res. 2006 Apr;50(4-5):451-5 [16534751] J Neurosci. 2006 Apr 19;26(16):4383-93 [16624958] Proc Natl Acad Sci U S A. 2001 Jan 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2017-01-18 ER - TY - JOUR T1 - Medication-related impulse control and repetitive behaviors in Parkinson's disease. AN - 70713942; 17620886 AB - A range of impulse control and repetitive behaviors presumed to be related to dopaminergic medications has been recognized in Parkinson's disease. These behaviors are linked by their incentive or reward-based and repetitive natures and overlap with addictions. The behaviors include pathological gambling, hypersexuality, compulsive shopping, and compulsive eating and are related to punding and compulsive medication use. In patients on dopamine agonists, these behaviors as a group are relatively common, can have potentially devastating psychosocial consequences and are commonly hidden. Recent studies have investigated prevalence rates and associated factors. The literature on these behaviors in Parkinson's disease, including definitions, epidemiology, pathophysiology and management, is reviewed. The relationship to medications, Parkinson's disease and individual susceptibility is examined. These behaviors can affect up to 14% of Parkinson's disease patients on dopamine agonists. Clinicians should warn patients prior to initiating dopamine agonists and enquire about these behaviors during follow up. JF - Current opinion in neurology AU - Voon, Valerie AU - Potenza, Marc N AU - Thomsen, Teri AD - Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institute of Health, Bethesda, Maryland 20892-1428, USA. voonv@ninds.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 484 EP - 492 VL - 20 IS - 4 SN - 1350-7540, 1350-7540 KW - Antiparkinson Agents KW - 0 KW - Dopamine Agonists KW - Receptors, Dopamine KW - Index Medicus KW - Reward KW - Humans KW - Neuronal Plasticity -- physiology KW - Receptors, Dopamine -- metabolism KW - Disruptive, Impulse Control, and Conduct Disorders -- epidemiology KW - Disruptive, Impulse Control, and Conduct Disorders -- chemically induced KW - Antiparkinson Agents -- adverse effects KW - Disruptive, Impulse Control, and Conduct Disorders -- physiopathology KW - Stereotyped Behavior KW - Compulsive Behavior -- chemically induced KW - Parkinson Disease -- complications KW - Dopamine Agonists -- adverse effects KW - Parkinson Disease -- physiopathology KW - Parkinson Disease -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70713942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+neurology&rft.atitle=Medication-related+impulse+control+and+repetitive+behaviors+in+Parkinson%27s+disease.&rft.au=Voon%2C+Valerie%3BPotenza%2C+Marc+N%3BThomsen%2C+Teri&rft.aulast=Voon&rft.aufirst=Valerie&rft.date=2007-08-01&rft.volume=20&rft.issue=4&rft.spage=484&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+neurology&rft.issn=13507540&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-27 N1 - Date created - 2007-07-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of simian virus-40 as a biological prognostic factor in Egyptian patients with malignant pleural mesothelioma. AN - 70704867; 17610473 AB - The association between simian virus (SV40) and malignant pleural mesothelioma (MPM) suggests an etiological role for SV40. However, exact pathogenetic mechanisms and possible prognostic value are not clear. The purpose of the present paper was to investigate 40 Egyptian MPM patients for the presence of SV40 DNA, altered Rb expression and p53 gene status using immunohistochemistry and molecular techniques. The relation between SV40, asbestos exposure, Rb, p53 and their contribution to the overall survival (OS) were also assessed. SV40 DNA was detected in 20/40 patients and asbestos exposure in 31 patients; 18 of them were SV40 positive. Altered p53 and Rb expression were detected in 57.5% and 52.5%, respectively, with no p53 mutation. Univariate analysis showed a significant correlation between OS and stage (P = 0.03), performance status (P = 0.04), p53 overexpression (P = 0.05), asbestos exposure (P = 0.002) and SV40 (P = 0.001). Multivariate analysis showed that when SV40 and asbestos exposure were considered together, only combined positivity of both was an independent prognostic factor affecting the OS (P = 0.001). SV40 and asbestos exposure are common in Egyptian MPM, denoting a possible etiological role and a synergistic effect for both agents. Combined positivity for SV40 and asbestos exposure is an independent prognostic factor in MPM, having a detrimental effect on OS. JF - Pathology international AU - Zekri, Abdel-Rahman N AU - Bahnassy, Abeer A AU - Mohamed, Waleed S AU - Hassan, Nelly AU - Abdel-Rahman, Abdel-Rahman M AU - El-Kassem, Fatma Abou AU - Gaafar, Rabab AD - Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt. ncizakri@starnet.com.eg Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 493 EP - 501 VL - 57 IS - 8 SN - 1320-5463, 1320-5463 KW - DNA, Viral KW - 0 KW - Retinoblastoma Protein KW - Tumor Suppressor Protein p53 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Asbestos -- poisoning KW - Fluorescent Antibody Technique, Indirect KW - Humans KW - Prognosis KW - Tumor Suppressor Protein p53 -- metabolism KW - Gene Expression Regulation, Neoplastic KW - Prospective Studies KW - Survival Rate KW - DNA, Viral -- analysis KW - Egypt -- epidemiology KW - Adult KW - Retinoblastoma Protein -- metabolism KW - Middle Aged KW - Tumor Suppressor Protein p53 -- genetics KW - Environmental Exposure -- adverse effects KW - Female KW - Male KW - Tumor Virus Infections -- virology KW - Simian virus 40 -- isolation & purification KW - Simian virus 40 -- genetics KW - Polyomavirus Infections -- pathology KW - Pleural Neoplasms -- mortality KW - Polyomavirus Infections -- virology KW - Pleural Neoplasms -- virology KW - Tumor Virus Infections -- pathology KW - Pleural Neoplasms -- pathology KW - Mesothelioma -- mortality KW - Mesothelioma -- pathology KW - Mesothelioma -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70704867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pathology+international&rft.atitle=Evaluation+of+simian+virus-40+as+a+biological+prognostic+factor+in+Egyptian+patients+with+malignant+pleural+mesothelioma.&rft.au=Zekri%2C+Abdel-Rahman+N%3BBahnassy%2C+Abeer+A%3BMohamed%2C+Waleed+S%3BHassan%2C+Nelly%3BAbdel-Rahman%2C+Abdel-Rahman+M%3BEl-Kassem%2C+Fatma+Abou%3BGaafar%2C+Rabab&rft.aulast=Zekri&rft.aufirst=Abdel-Rahman&rft.date=2007-08-01&rft.volume=57&rft.issue=8&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Pathology+international&rft.issn=13205463&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-20 N1 - Date created - 2007-07-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Stress-induced relapse to cocaine seeking: roles for the CRF(2) receptor and CRF-binding protein in the ventral tegmental area of the rat. AN - 70677169; 17437087 AB - Footshock reinstates cocaine seeking in cocaine-experienced rats by inducing corticotropin-releasing factor (CRF) and glutamate release in the ventral tegmental area (VTA) and thus activating VTA dopaminergic neurons. Footshock-induced VTA glutamate release, dopamine activation and reinstatements are blocked by VTA administration of a alpha-helical CRF, a nonselective CRF receptor antagonist. The effects of selective CRF antagonists have not yet been reported. The present studies were designed to explore the roles of VTA CRF receptor subtypes and CRF-BP in these effects induced by footshock. Rats were first trained to lever-press for intravenous cocaine (1 mg/infusion/0.13 ml, FR-1 schedule), and then tested under extinction conditions until response rates returned to the pretraining baseline. Reinstatements, VTA glutamate and dopamine levels [microdialysis with high performance liquid chromatography (HPLC)] were then assessed, under various pharmacological conditions, after mild inescapable footshock. Footshock-induced reinstatement of cocaine seeking and release of VTA glutamate and dopamine were blocked by selective blockade of VTA CRF(2) receptors (CRF(2)Rs) but not CRF(1)Rs. VTA perfusion of CRF or CRF(2)R agonists that have strong affinity for CRF-BP mimicked the effects induced by footshock while CRFR agonists that do not bind CRF-BP were ineffective. CRF(6-33), which competes for the CRF binding site on CRF-BP, attenuated the effects of CRF or urocortin I on VTA glutamate and dopamine release and on reinstatement of cocaine seeking. The present studies revealed a role of VTA CRF-BP and suggest an involvement of CRF(2)R in the effectiveness of stress in triggering glutamate and dopamine release and cocaine seeking in drug-experienced animals. JF - Psychopharmacology AU - Wang, Bin AU - You, Zhi-Bing AU - Rice, Kenner C AU - Wise, Roy A AD - Behavioral Neuroscience Branch, Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 283 EP - 294 VL - 193 IS - 2 SN - 0033-3158, 0033-3158 KW - CRF receptor type 1 KW - 0 KW - CRF receptor type 2 KW - Carrier Proteins KW - Receptors, Corticotropin-Releasing Hormone KW - alpha helical corticotropin-releasing hormone KW - corticotropin releasing factor-binding protein KW - 134773-81-2 KW - Glutamic Acid KW - 3KX376GY7L KW - Corticotropin-Releasing Hormone KW - 9015-71-8 KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Conditioning, Operant -- drug effects KW - Animals KW - Glutamic Acid -- metabolism KW - Rats, Long-Evans KW - Dopamine -- metabolism KW - Cocaine -- administration & dosage KW - Protein Binding KW - Recurrence KW - Rats KW - Behavior, Animal -- drug effects KW - Self Administration KW - Cocaine -- pharmacology KW - Electroshock KW - Male KW - Carrier Proteins -- metabolism KW - Receptors, Corticotropin-Releasing Hormone -- metabolism KW - Cocaine-Related Disorders -- psychology KW - Corticotropin-Releasing Hormone -- antagonists & inhibitors KW - Cocaine-Related Disorders -- physiopathology KW - Ventral Tegmental Area -- metabolism KW - Receptors, Corticotropin-Releasing Hormone -- antagonists & inhibitors KW - Corticotropin-Releasing Hormone -- agonists KW - Cocaine-Related Disorders -- etiology KW - Corticotropin-Releasing Hormone -- pharmacology KW - Corticotropin-Releasing Hormone -- metabolism KW - Stress, Psychological -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70677169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Stress-induced+relapse+to+cocaine+seeking%3A+roles+for+the+CRF%282%29+receptor+and+CRF-binding+protein+in+the+ventral+tegmental+area+of+the+rat.&rft.au=Wang%2C+Bin%3BYou%2C+Zhi-Bing%3BRice%2C+Kenner+C%3BWise%2C+Roy+A&rft.aulast=Wang&rft.aufirst=Bin&rft.date=2007-08-01&rft.volume=193&rft.issue=2&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-20 N1 - Date created - 2007-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Oligodendroglial abnormalities in schizophrenia, mood disorders and substance abuse. Comorbidity, shared traits, or molecular phenocopies? AN - 70656322; 17291372 AB - The evidence implicating oligodendroglia in major mental disorders has grown significantly in the past few years. Microarray analysis revealed altered expression of oligodendroglia-related genes in multiple brain regions from several, clinically diverse groups of subjects with schizophrenia (SZ) as well as subjects with bipolar disorder (BD) and major depressive disorders (MDD), alcoholics and cocaine users. In line with gene expression findings, evidence for ultrastructural changes in white matter and altered oligodendroglia in these disorders were reported in neuroimaging and neuropathological studies. Changes in oligodendroglia-related genes reported in SZ, BD and MDD appear to display considerable similarities (particularly decreased expression of MAG, ERBB, TF, PLP1, MOG, MOBP, MOG), while changes in cocaine abuse and alcoholism are more diverse. Common oligodendroglial abnormalities might indicate aetiological or pathophysiological overlaps between different disorders. The possible mechanisms of oligodendroglial abnormalities may involve functional variations in oligodendroglia-related genes, epigenetic regulation of chromatin, DA system hyperactivity and other mechanisms. JF - The international journal of neuropsychopharmacology AU - Sokolov, Boris P AD - Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD, USA. BSokolov@intra.nida.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 547 EP - 555 VL - 10 IS - 4 SN - 1461-1457, 1461-1457 KW - Nerve Tissue Proteins KW - 0 KW - Index Medicus KW - Phenotype KW - Humans KW - Nerve Tissue Proteins -- metabolism KW - Gene Expression Regulation KW - Myelin Sheath -- metabolism KW - Genetic Predisposition to Disease KW - Nerve Tissue Proteins -- genetics KW - Epigenesis, Genetic KW - Comorbidity KW - Oligodendroglia -- pathology KW - Alcoholism -- pathology KW - Schizophrenia -- metabolism KW - Alcoholism -- metabolism KW - Schizophrenia -- pathology KW - Alcoholism -- genetics KW - Mood Disorders -- genetics KW - Mood Disorders -- pathology KW - Oligodendroglia -- metabolism KW - Cocaine-Related Disorders -- genetics KW - Cocaine-Related Disorders -- pathology KW - Schizophrenia -- genetics KW - Cocaine-Related Disorders -- metabolism KW - Mood Disorders -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70656322?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+international+journal+of+neuropsychopharmacology&rft.atitle=Oligodendroglial+abnormalities+in+schizophrenia%2C+mood+disorders+and+substance+abuse.+Comorbidity%2C+shared+traits%2C+or+molecular+phenocopies%3F&rft.au=Sokolov%2C+Boris+P&rft.aulast=Sokolov&rft.aufirst=Boris&rft.date=2007-08-01&rft.volume=10&rft.issue=4&rft.spage=547&rft.isbn=&rft.btitle=&rft.title=The+international+journal+of+neuropsychopharmacology&rft.issn=14611457&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-18 N1 - Date created - 2007-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Therapy for metastatic ESFT: is it time to ask new questions? AN - 70614716; 17474114 JF - Pediatric blood & cancer AU - Snyder, Kristen M AU - Mackall, Crystal L AD - Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 115 EP - 116 VL - 49 IS - 2 SN - 1545-5009, 1545-5009 KW - Antineoplastic Agents, Alkylating KW - 0 KW - Index Medicus KW - Neuroectodermal Tumors, Primitive -- secondary KW - Multicenter Studies as Topic KW - Neuroectodermal Tumors, Primitive -- drug therapy KW - Combined Modality Therapy KW - Humans KW - Treatment Outcome KW - Clinical Trials as Topic KW - Pilot Projects KW - Bone Neoplasms -- pathology KW - Transplantation, Autologous KW - Neuroectodermal Tumors, Primitive -- surgery KW - Antineoplastic Agents, Alkylating -- therapeutic use KW - Peripheral Blood Stem Cell Transplantation KW - Sarcoma, Ewing -- secondary KW - Sarcoma, Ewing -- surgery KW - Antineoplastic Agents, Alkylating -- administration & dosage KW - Sarcoma, Ewing -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70614716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+blood+%26+cancer&rft.atitle=Therapy+for+metastatic+ESFT%3A+is+it+time+to+ask+new+questions%3F&rft.au=Snyder%2C+Kristen+M%3BMackall%2C+Crystal+L&rft.aulast=Snyder&rft.aufirst=Kristen&rft.date=2007-08-01&rft.volume=49&rft.issue=2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Pediatric+blood+%26+cancer&rft.issn=15455009&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-24 N1 - Date created - 2007-06-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Pediatr Blood Cancer. 2007 Aug;49(2):196-8 [17417796] Pediatr Blood Cancer. 2007 Aug;49(2):190-5 [17262797] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Teratogenicity risk of antiretroviral therapy in pregnancy. AN - 68303082; 17883999 AB - Highly active antiretroviral regimens are recommended for use in pregnancy to prevent vertical transmission of HIV, and many women enter pregnancy already on these regimens for their own health. Sources of data on the potential teratogenicity of antiretroviral drugs include animal studies, cohort studies, the Antiretroviral Pregnancy Registry, and case reports, but data on newly approved drugs are often limited. Thus far, concerns have been identified regarding a potential association between first trimester efavirenz exposure and neural tube defects based on a study in monkeys and case reports in humans, a possible association between first trimester exposure to zidovudine and an increased risk of hypospadias based on one cohort study, and an increased risk of septal heart defects in animals with delavirdine. Additional data on risks of antiretrovirals during pregnancy are needed. Providers should report cases of antiretroviral drug exposures during pregnancy to the Antiretroviral Pregnancy Registry. JF - Current HIV/AIDS reports AU - Watts, D Heather AD - Pediatric, Adolescent, and Maternal AIDS Branch, CRMC/NICHD/NIH, 6100 Executive Boulevard, Room 4B11, Bethesda, MD 20892, USA. hw59i@nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 135 EP - 140 VL - 4 IS - 3 SN - 1548-3568, 1548-3568 KW - Anti-Retroviral Agents KW - 0 KW - Teratogens KW - Index Medicus KW - Animals KW - Risk Factors KW - Humans KW - Infant, Newborn KW - Female KW - Pregnancy KW - Infectious Disease Transmission, Vertical -- prevention & control KW - HIV Infections -- transmission KW - HIV Infections -- prevention & control KW - Anti-Retroviral Agents -- adverse effects KW - Abnormalities, Drug-Induced -- etiology KW - Anti-Retroviral Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68303082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+HIV%2FAIDS+reports&rft.atitle=Teratogenicity+risk+of+antiretroviral+therapy+in+pregnancy.&rft.au=Watts%2C+D+Heather&rft.aulast=Watts&rft.aufirst=D&rft.date=2007-08-01&rft.volume=4&rft.issue=3&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Current+HIV%2FAIDS+reports&rft.issn=15483568&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-05 N1 - Date created - 2007-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Excess lifetime cancer mortality risk attributable to radiation exposure from computed tomography examinations in children. AN - 68285609; 17877063 AB - The use of computed tomography in Israel has been growing rapidly during recent decades. The major drawback of this important technology is the exposure to ionizing radiation, especially among children who have increased organ radiosensitivity and a long lifetime to potentially develop radiation-related cancer. To estimate the number of excess lifetime cancer deaths related to annual CT scans performed in children in Israel. We used CT scan utilization data from 1999 to 2003 obtained from the second largest health management organization in the country to project age and gender-specific CT scan use nationwide. Based on published organ doses for common CT examinations and radiation-related cancer mortality risk estimates from studies in survivors of the atomic bomb, we estimated the excess lifetime risks for cancer mortality attributed to use of CT in children and adolescents (up to 18 years old) in Israel. We estimated that 17,686 pediatric scans were conducted annually in Israel during 1999-2003. We project that 9.5 lifetime deaths would be associated with 1 year of pediatric CT scanning. This number represents an excess of 0.29% over the total number of patients who are eventually estimated to die from cancer in their lifetime. Pediatric CT scans in Israel may result in a small but not negligible increased lifetime risk for cancer mortality. Because of the uncertainty regarding radiation effects at low doses, our estimates of CT-related cancer mortality should be considered with caution. Nevertheless, physicians, CT technologists, and health authorities should work together to minimize the radiation dose for children to as low as reasonably achievable and encourage responsible use of this essential diagnostic tool. JF - The Israel Medical Association journal : IMAJ AU - Chodick, Gabriel AU - Ronckers, Cécile M AU - Shalev, Varda AU - Ron, Elaine AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892-7238, USA. hodik_g@mac.org.il Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 584 EP - 587 VL - 9 IS - 8 SN - 1565-1088, 1565-1088 KW - Index Medicus KW - Infant KW - Radiation Dosage KW - Humans KW - Child KW - Adolescent KW - Stomach -- diagnostic imaging KW - Brain -- diagnostic imaging KW - Male KW - Female KW - Survival Analysis KW - Risk Assessment KW - Child, Preschool KW - Tomography, X-Ray Computed -- adverse effects KW - Neoplasms, Radiation-Induced -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68285609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Israel+Medical+Association+journal+%3A+IMAJ&rft.atitle=Excess+lifetime+cancer+mortality+risk+attributable+to+radiation+exposure+from+computed+tomography+examinations+in+children.&rft.au=Chodick%2C+Gabriel%3BRonckers%2C+C%C3%A9cile+M%3BShalev%2C+Varda%3BRon%2C+Elaine&rft.aulast=Chodick&rft.aufirst=Gabriel&rft.date=2007-08-01&rft.volume=9&rft.issue=8&rft.spage=584&rft.isbn=&rft.btitle=&rft.title=The+Israel+Medical+Association+journal+%3A+IMAJ&rft.issn=15651088&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-02 N1 - Date created - 2007-09-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Isr Med Assoc J. 2007 Aug;9(8):607-9 [17877069] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sun exposure measurements in populations. AN - 68266756; 17867377 JF - Nutrition reviews AU - Tucker, Margaret A AD - Human Genetics Program, Chief, Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., Room 7122, Bethesda, MD 20892-7236, USA. tuckerp@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - S84 EP - S86 VL - 65 IS - 8 Pt 2 SN - 0029-6643, 0029-6643 KW - Vitamin D KW - 1406-16-2 KW - Index Medicus KW - Epidemiologic Methods KW - Humans KW - Sunlight -- adverse effects KW - Skin Neoplasms -- etiology KW - Environmental Exposure -- analysis KW - Ultraviolet Rays -- adverse effects KW - Skin Neoplasms -- epidemiology KW - Vitamin D -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68266756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nutrition+reviews&rft.atitle=Sun+exposure+measurements+in+populations.&rft.au=Tucker%2C+Margaret+A&rft.aulast=Tucker&rft.aufirst=Margaret&rft.date=2007-08-01&rft.volume=65&rft.issue=8+Pt+2&rft.spage=S84&rft.isbn=&rft.btitle=&rft.title=Nutrition+reviews&rft.issn=00296643&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-12 N1 - Date created - 2007-09-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The biology behind mTOR inhibition in sarcoma. AN - 68230176; 17766661 AB - Dysregulation of the mammalian target of rapamycin (mTOR) pathway has been found in many human tumors and implicated in the promotion of cancer cell growth and survival. Hence, the mTOR pathway is considered an important target for anticancer drug development. Currently, the mTOR inhibitor rapamycin and its derivatives CCI-779, RAD001, and AP23573 are being evaluated in cancer clinical trials. To date, clinical results have shown good tolerability of treatment with mTOR inhibitors in most reports and varying effectiveness of mTOR inhibitors in a variety of tumors in a subset of patients. For the targeted treatment of sarcomas, AP23573 has shown promising clinical efficacy and low toxicity profiles in patients. Further studies should define the optimal dose/schedule, patient selection, and combination strategies with other biological agents, especially those targeting signaling pathways crucial for cell survival. Disclosure of potential conflicts of interest is found at the end of this article. JF - The oncologist AU - Wan, Xiaolin AU - Helman, Lee J AD - Molecular Oncology Section, Pediatric Oncology Branch, Building 10, Room CRC-1W-3816, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1928, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1007 EP - 1018 VL - 12 IS - 8 SN - 1083-7159, 1083-7159 KW - Protein Kinase Inhibitors KW - 0 KW - ridaforolimus KW - 48Z35KB15K KW - temsirolimus KW - 624KN6GM2T KW - Everolimus KW - 9HW64Q8G6G KW - Protein Kinases KW - EC 2.7.- KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - MTOR protein, human KW - EC 2.7.1.1 KW - TOR Serine-Threonine Kinases KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Sirolimus KW - W36ZG6FT64 KW - Index Medicus KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Humans KW - Clinical Trials as Topic KW - Protein Kinase Inhibitors -- therapeutic use KW - Protein Kinase Inhibitors -- pharmacology KW - Protein Kinases -- drug effects KW - Sirolimus -- pharmacology KW - Protein Kinase Inhibitors -- chemistry KW - Sirolimus -- therapeutic use KW - Sarcoma -- drug therapy KW - Sarcoma -- enzymology KW - Sirolimus -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68230176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=The+biology+behind+mTOR+inhibition+in+sarcoma.&rft.au=Wan%2C+Xiaolin%3BHelman%2C+Lee+J&rft.aulast=Wan&rft.aufirst=Xiaolin&rft.date=2007-08-01&rft.volume=12&rft.issue=8&rft.spage=1007&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=10837159&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-31 N1 - Date created - 2007-09-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Seasonal birth patterns in myositis subgroups suggest an etiologic role of early environmental exposures. AN - 68207181; 17665425 AB - To evaluate whether seasonal early environmental exposures might influence later development of autoimmune disease, by assessing distributions of birth dates in groups of patients with idiopathic inflammatory myopathies (IIMs). We assessed birth patterns in groups of patients with juvenile-onset IIM (n = 307) and controls (n = 3,942) who were born between 1970 and 1999, and in groups of patients with adult-onset IIM (n = 668) and controls (n = 6,991) who were born between 1903 and 1982. Birth dates were analyzed as circular data. Seasonal clustering was assessed by the Rayleigh test, and differences between groups by a rank-based uniform scores test. The overall birth distributions among patients with juvenile IIM and among patients with adult IIM did not differ significantly from those among juvenile and adult controls, respectively. Some subgroups of patients with juvenile IIM had seasonal birth distributions. Hispanic patients with juvenile-onset IIM had a seasonal birth pattern (mean birth date October 16) significantly different from that of Hispanic controls (P = 0.002), who had a uniform birth distribution, and from that of non-Hispanic patients with juvenile-onset IIM (P < 0.001), who had a mean birth date of May 2. Juvenile dermatomyositis patients with p155 autoantibody had a birth distribution that differed significantly from that of p155 antibody-negative juvenile dermatomyositis patients (P = 0.003). Juvenile IIM patients with the HLA risk factor allele DRB1*0301 had a birth distribution significantly different from those without the allele (P = 0.021). Similar results were observed for juvenile and adult IIM patients with the linked allele DQA1*0501, versus juvenile and adult IIM patients without DQA1*0501, respectively. No significant patterns in birth season were found in other subgroups. Birth distributions appear to have stronger seasonality in juvenile than in adult IIM subgroups, suggesting greater influence of perinatal exposures on childhood-onset illness. Seasonal early-life exposures may influence the onset of some autoimmune diseases later in life. JF - Arthritis and rheumatism AU - Vegosen, Leora J AU - Weinberg, Clarice R AU - O'Hanlon, Terrance P AU - Targoff, Ira N AU - Miller, Frederick W AU - Rider, Lisa G AD - Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, NIH/DHHS, 10 Center Drive, Bethesda, MD 20892, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 2719 EP - 2728 VL - 56 IS - 8 SN - 0004-3591, 0004-3591 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Parturition KW - United States -- epidemiology KW - Time Factors KW - Cluster Analysis KW - Seasons KW - Myositis -- epidemiology KW - Environmental Exposure -- adverse effects KW - Myositis -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68207181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+and+rheumatism&rft.atitle=Seasonal+birth+patterns+in+myositis+subgroups+suggest+an+etiologic+role+of+early+environmental+exposures.&rft.au=Vegosen%2C+Leora+J%3BWeinberg%2C+Clarice+R%3BO%27Hanlon%2C+Terrance+P%3BTargoff%2C+Ira+N%3BMiller%2C+Frederick+W%3BRider%2C+Lisa+G&rft.aulast=Vegosen&rft.aufirst=Leora&rft.date=2007-08-01&rft.volume=56&rft.issue=8&rft.spage=2719&rft.isbn=&rft.btitle=&rft.title=Arthritis+and+rheumatism&rft.issn=00043591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-18 N1 - Date created - 2007-08-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hum Reprod. 1992 Jul;7(6):735-45 [1323571] BMJ. 1999 Oct 2;319(7214):887-8 [10506043] J Rheumatol. 1999 Feb;26(2):352-60 [9972969] J Immunol. 1997 Dec 15;159(12):6260-5 [9550430] Demography. 1996 Aug;33(3):291-305 [8875063] Arthritis Rheum. 1998 Mar;41(3):392-9 [9506565] Chronobiol Int. 1999 Sep;16(5):581-622 [10513884] J Am Coll Nutr. 2004 Dec;23(6 Suppl):588S-595S [15640511] BMJ. 2005 Jan 15;330(7483):120 [15585537] Immunol Cell Biol. 2005 Feb;83(1):9-17 [15661036] Isr Med Assoc J. 2005 Jun;7(6):381-4 [15984382] Arthritis Rheum. 2005 Aug;52(8):2433-8 [16052581] BMC Public Health. 2005;5:102 [16207379] N Engl J Med. 2005 Oct 27;353(17):1848-50 [16251542] Medicine (Baltimore). 2005 Nov;84(6):338-49 [16267409] Environ Health Perspect. 2005 Dec;113(12):1787-90 [16330365] Environ Health Perspect. 2005 Dec;113(12):1802-7 [16330368] Pediatr Pulmonol. 2006 Dec;41(12):1125-8 [17034060] Arthritis Rheum. 2006 Nov;54(11):3682-9 [17075819] Lupus. 2006;15(11):794-800 [17153853] Environ Health Perspect. 2006 Dec;114(12):1916-22 [17185285] Am J Psychiatry. 2000 Jul;157(7):1173-5 [10873932] Environ Health Perspect. 1999 Oct;107 Suppl 5:793-802 [10970168] J Pediatr Endocrinol Metab. 2001 Jan;14(1):47-52 [11220705] Emerg Infect Dis. 2001 May-Jun;7(3):369-74 [11384511] Hum Reprod. 2001 Jul;16(7):1512-7 [11425840] Environ Health Perspect. 2002 Jun;110 Suppl 3:441-9 [12060842] Arthritis Rheum. 2002 Jul;46(7):1885-93 [12124873] Gut. 2002 Dec;51(6):814-5 [12427782] Best Pract Res Clin Rheumatol. 2002 Dec;16(5):817-32 [12473276] Stat Med. 2003 Jul 15;22(13):2127-35 [12820278] Arthritis Rheum. 2003 Aug;48(8):2285-93 [12905483] Sleep. 2003 Sep15;26(6):663-5 [14572117] Diabetologia. 2004 Apr;47(4):614-21 [15298337] Am J Gastroenterol. 2004 Oct;99(10):1974-6 [15447759] N Engl J Med. 1975 Feb 13;292(7):344-7 [1090839] N Engl J Med. 1992 May 21;326(21):1380-4 [1472183] J Immunol. 1990 Mar 1;144(5):1737-43 [2307838] Diabetologia. 1984 Mar;26(3):199-202 [6609096] Lancet. 1988 Jun 25;1(8600):1461 [2898612] J Rheumatol. 1989 Sep;16(9):1225-8 [2681763] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Herbal hepatotoxicity. AN - 68205721; 17723921 AB - There is appropriate concern about the potential risk for hepatotoxicity from herbal products because they are unregulated and therefore not standardized with regard to their contents. This is particularly the case for the crude herbals that are commonly formulated as a mixture, so that their ingredients may be ambiguous and even contain harmful contaminants. Presented here is an overview of the more commonly recognized herbal products that have been reported to be associated with liver injury. Although many of them are clearly implicated, there are some, particularly those identified solely through an occasional case report, for which the relationship is uncertain. JF - Clinics in liver disease AU - Seeff, Leonard B AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 31 Center Drive, Room 9A27, Bethesda, MD 20892, USA. seeffl@extra.niddk.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 577 EP - 96, vii VL - 11 IS - 3 SN - 1089-3261, 1089-3261 KW - Drugs, Chinese Herbal KW - 0 KW - Plant Preparations KW - Index Medicus KW - Humans KW - Herb-Drug Interactions KW - Drugs, Chinese Herbal -- adverse effects KW - Plant Preparations -- adverse effects KW - Chemical and Drug Induced Liver Injury KW - Plants, Medicinal -- adverse effects KW - Phytotherapy -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68205721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinics+in+liver+disease&rft.atitle=Herbal+hepatotoxicity.&rft.au=Seeff%2C+Leonard+B&rft.aulast=Seeff&rft.aufirst=Leonard&rft.date=2007-08-01&rft.volume=11&rft.issue=3&rft.spage=577&rft.isbn=&rft.btitle=&rft.title=Clinics+in+liver+disease&rft.issn=10893261&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-08 N1 - Date created - 2007-08-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Analysis of toxicity in patients with high risk prostate cancer treated with intensity-modulated pelvic radiation therapy and simultaneous integrated dose escalation to prostate area. AN - 68201025; 17692416 AB - To report the treatment-related morbidity in patients with prostate cancer treated with an optimized pelvic intensity-modulated radiation therapy (IMRT) and simultaneous integrated dose escalation to prostate/prostate bed. Between November 2003 and May 2006, 55 patients with localized prostate cancer and >15% risk of lymph node involvement were treated with pelvic IMRT and simultaneous dose escalation to prostate area. Twenty-four patients received a radical radiation therapy program, and the remaining thirty-one patients received a postoperative irradiation as adjuvant treatment or after biochemical or macroscopic local/regional relapse. After a customized immobilization all patients underwent contrast-enhanced CT. On the CT slices CTV1 and CTV2 were delineated. CTV(1) included the prostate and seminal vesicles or prostate bed. CTV(2) consisted of CTV(1) plus pelvic nodes. CTV(1) and CTV(2) were then expanded by 0.5 and 1cm, respectively, to generate the planning target volumes. IMRT treatment plans were generated using commercial inverse planning software. Total doses of 66-80 Gy and 50-59 Gy in 33-40 fractions were prescribed to the prostate area and pelvis, respectively. The worst acute and late rectal, intestinal and GU toxicities during and after treatment were scored according to the EORTC/RTOG scales. The IMRT dose distribution provided excellent PTV coverage and satisfying sparing of all the organs at risk, with no patient experiencing >grade 2 acute or late toxicities. Patients without acute grade 2 intestinal, rectal, and GU toxicity were 91%, 71%, and 63%, respectively. After a median follow-up of 19 months (interquartile range of 9 to 28 months), late grade 2 toxicity was detected only for rectum, with an actuarial 2-year rate of freedom from G2 rectal bleeding of 92%. (CI 95% 0.83-0.99.) Pelvic IMRT and simultaneous dose escalation to prostate area is a well-tolerated technique in patients with prostate cancer requiring treatment of pelvic lymph nodes, and seems to be associated with a lower frequency and severity of side effects when compared with conventional techniques reported in other series. JF - Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology AU - Arcangeli, Stefano AU - Saracino, Biancamaria AU - Petrongari, Maria Grazia AU - Gomellini, Sara AU - Marzi, Simona AU - Landoni, Valeria AU - Gallucci, Michele AU - Sperduti, Isabella AU - Arcangeli, Giorgio AD - Department of Radiation Oncology, Regina Elena National Cancer Institute, Rome, Italy. arcangeli@ifo.it Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 148 EP - 155 VL - 84 IS - 2 SN - 0167-8140, 0167-8140 KW - Index Medicus KW - Radiotherapy Planning, Computer-Assisted KW - Radiation Dosage KW - Radiotherapy, Adjuvant KW - Aged, 80 and over KW - Humans KW - Aged KW - Middle Aged KW - Follow-Up Studies KW - Male KW - Prostate -- radiation effects KW - Pelvis -- radiation effects KW - Radiotherapy, Intensity-Modulated -- adverse effects KW - Prostatic Neoplasms -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68201025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiotherapy+and+oncology+%3A+journal+of+the+European+Society+for+Therapeutic+Radiology+and+Oncology&rft.atitle=Analysis+of+toxicity+in+patients+with+high+risk+prostate+cancer+treated+with+intensity-modulated+pelvic+radiation+therapy+and+simultaneous+integrated+dose+escalation+to+prostate+area.&rft.au=Arcangeli%2C+Stefano%3BSaracino%2C+Biancamaria%3BPetrongari%2C+Maria+Grazia%3BGomellini%2C+Sara%3BMarzi%2C+Simona%3BLandoni%2C+Valeria%3BGallucci%2C+Michele%3BSperduti%2C+Isabella%3BArcangeli%2C+Giorgio&rft.aulast=Arcangeli&rft.aufirst=Stefano&rft.date=2007-08-01&rft.volume=84&rft.issue=2&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Radiotherapy+and+oncology+%3A+journal+of+the+European+Society+for+Therapeutic+Radiology+and+Oncology&rft.issn=01678140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-23 N1 - Date created - 2007-08-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hair dye use, genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), and risk of non-Hodgkin lymphoma. AN - 68180117; 17522066 AB - Several previous studies have found non-Hodgkin lymphoma (NHL) risk to be associated with hair dye use, particularly use of permanent, dark colors and use before 1980, when hair dye formulations changed. We examined NHL risk in relation to reported hair dye use among 1,321 cases and 1,057 controls from a US population-based multi-center study. DNA was extracted from blood or buccal cells to identify genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2), which encode enzymes that metabolize aromatic amine compounds found in hair dyes. Among women, 509 cases and 413 controls reported hair dye use [odds ratio (OR) = 1.2; 95% confidence interval (95% CI) = 0.9, 1.6]. Risk estimates were higher for use before 1980 than for use in 1980 or later, particularly for use of permanent, intense tone (black, dark brown, dark blonde) products (or=1980-OR = 0.6; 95% CI 0.4, 1.1). Risk estimates were increased for women who used permanent, intense tone products before 1980 if they had the rapid/intermediate NAT2 phenotype (OR = 3.3; 95% CI 1.3, 8.6) or the NAT1 10 allele (OR = 2.5; 95% CI 0.9, 7.6), but not if they were slow NAT2 acetylators (OR = 1.5; 95% CI 0.6, 3.6) or had no copies of the NAT1 10 allele (OR = 1.5; 95% CI 0.7, 3.3). NHL risk was not increased among women who began hair dye use after 1980 or among men. Our results support previous research demonstrating elevated NHL risk among women who used dark color or intense tone permanent hair dyes before 1980. We present the first evidence suggesting that this risk may differ by genetic variation in NAT1 and NAT2. JF - Carcinogenesis AU - Morton, Lindsay M AU - Bernstein, Leslie AU - Wang, Sophia S AU - Hein, David W AU - Rothman, Nathaniel AU - Colt, Joanne S AU - Davis, Scott AU - Cerhan, James R AU - Severson, Richard K AU - Welch, Robert AU - Hartge, Patricia AU - Zahm, Shelia Hoar AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA. mortonli@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1759 EP - 1764 VL - 28 IS - 8 SN - 0143-3334, 0143-3334 KW - Hair Dyes KW - 0 KW - Isoenzymes KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - N-acetyltransferase 1 KW - NAT2 protein, human KW - Index Medicus KW - Risk Factors KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Male KW - Female KW - Lymphoma, Non-Hodgkin -- genetics KW - Genetic Variation KW - Lymphoma, Non-Hodgkin -- etiology KW - Lymphoma, Non-Hodgkin -- enzymology KW - Hair Dyes -- adverse effects KW - Genetic Predisposition to Disease KW - Isoenzymes -- genetics KW - Arylamine N-Acetyltransferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68180117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Hair+dye+use%2C+genetic+variation+in+N-acetyltransferase+1+%28NAT1%29+and+2+%28NAT2%29%2C+and+risk+of+non-Hodgkin+lymphoma.&rft.au=Morton%2C+Lindsay+M%3BBernstein%2C+Leslie%3BWang%2C+Sophia+S%3BHein%2C+David+W%3BRothman%2C+Nathaniel%3BColt%2C+Joanne+S%3BDavis%2C+Scott%3BCerhan%2C+James+R%3BSeverson%2C+Richard+K%3BWelch%2C+Robert%3BHartge%2C+Patricia%3BZahm%2C+Shelia+Hoar&rft.aulast=Morton&rft.aufirst=Lindsay&rft.date=2007-08-01&rft.volume=28&rft.issue=8&rft.spage=1759&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-19 N1 - Date created - 2007-08-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 1994 Jun 15;86(12):941-4 [8196085] Carcinogenesis. 2006 Aug;27(8):1600-6 [16497705] Cancer Causes Control. 1999 Dec;10(6):617-25 [10616830] Cancer Epidemiol Biomarkers Prev. 2000 Jan;9(1):29-42 [10667461] Pharmacogenetics. 2000 Jun;10(4):291-2 [10862519] Drug Metab Dispos. 2000 Dec;28(12):1425-32 [11095579] Int J Cancer. 2001 Feb 15;91(4):575-9 [11251984] Cancer Epidemiol Biomarkers Prev. 2001 Jun;10(6):687-96 [11401920] Pharmacogenomics. 2002 Jan;3(1):19-30 [11966400] Br J Haematol. 2002 Aug;118(2):477-81 [12139735] Mutat Res. 2002 Sep 30;506-507:65-77 [12351146] Carcinogenesis. 2003 Mar;24(3):483-9 [12663508] Chem Res Toxicol. 2003 Sep;16(9):1162-73 [12971805] Am J Epidemiol. 2004 Jan 15;159(2):148-54 [14718216] Curr Pharm Des. 2004;10(20):2519-24 [15320760] Proc Natl Acad Sci U S A. 1975 Jun;72(6):2423-7 [1094469] J Environ Pathol Toxicol. 1980 Mar;3(4 Spec No):237-51 [6993608] J Natl Cancer Inst. 1981 Mar;66(3):591-602 [6937712] Cancer Chemother Pharmacol. 1987;20(3):235-8 [3677298] Am J Public Health. 1988 May;78(5):570-1 [3354743] Zhonghua Yu Fang Yi Xue Za Zhi. 1990 Nov;24(6):328-31 [2099267] Am J Public Health. 1992 Jul;82(7):990-7 [1609918] J Natl Cancer Inst. 1994 Feb 2;86(3):210-5 [8283493] J Toxicol Environ Health B Crit Rev. 2006 Sep-Oct;9(5):413-39 [17492526] IARC Monogr Eval Carcinog Risks Hum. 1993;57:7-398 [7911535] J Natl Cancer Inst. 1994 Oct 5;86(19):1466-70 [8089866] Am J Public Health. 1998 Dec;88(12):1767-73 [9842372] Am J Ind Med. 1999 Jul;36(1):60-9 [10361588] Carcinogenesis. 1999 Jul;20(7):1225-9 [10383893] Pol J Pharmacol. 2004 Jul-Aug;56(4):445-9 [15520499] Int J Cancer. 2005 Feb 10;113(4):629-31 [15389468] Br J Haematol. 2005 Mar;128(5):610-5 [15725081] JAMA. 2005 May 25;293(20):2516-25 [15914752] JAMA. 2005 Sep 14;294(10):1205; author reply 1205 [16160127] Cancer Causes Control. 2005 Dec;16(10):1203-14 [16215871] Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2449-53 [16214931] Int J Epidemiol. 2005 Oct;34(5):1118-22 [15914502] Int J Cancer. 2006 Jan 1;118(1):161-8 [16003747] Nucleic Acids Res. 2006 Jan 1;34(Database issue):D617-21 [16381944] Am J Epidemiol. 2006 Feb 1;163(3):197-203 [16339049] Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):251-7 [16492912] Oncogene. 2006 Mar 13;25(11):1649-58 [16550165] Eur J Cancer. 2006 Jul;42(10):1448-54 [16740387] Am J Epidemiol. 2006 Jul 1;164(1):47-55 [16731576] Pharmacogenet Genomics. 2006 Aug;16(8):537-45 [16847422] Comment In: Carcinogenesis. 2008 May;29(5):1084-5 [18212328] Carcinogenesis. 2008 Sep;29(9):1851 [18218828] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer risk. AN - 68179865; 17557904 AB - The double-strand break DNA repair (DSBR) pathway is implicated in maintaining genomic stability and therefore could affect bladder cancer risk. Here we present data evaluating 39 single-nucleotide polymorphisms (SNPs) in seven candidate genes whose products are involved in DNA break sensing (NBS1, BRCA1 interacting genes BRIP1 and ZNF350), non-homologous end-joining (NHEJ) DNA repair (XRCC4) and homologous recombination (HR) repair (RAD51, XRCC2 and XRCC3). SNPs for RAD51 and XRCC2 covered most of the common variation. Associations with bladder cancer risk were evaluated in 1,150 newly diagnosed cases of urinary bladder transitional cell carcinomas and 1,149 controls conducted in Spain during 1997-2001. We found that the genetic variants evaluated significantly contributed to bladder cancer risk (global likelihood ratio test P = 0.01). Subjects with the ZNF350 R501S (rs2,278,415) variant allele showed significantly reduced risk compared with common homozygote variants, odds ratio (OR) [95% confidence interval (95% CI)]: 0.76 (0.62-0.93) per variant allele. Carriers of a putative functional SNP in intron 7 of XRCC4 (rs1,805,377) had significantly increased bladder cancer risk compared with common homozygotes: 1.33 (1.08-1.64) per variant allele. Lastly, XRCC2 homozygote variants for three promoter SNPs (rs10,234,749, rs6,464,268, rs3,218,373) and one non-synonymous SNP (rs3,218,536, R188H) were associated with reduced bladder cancer risk (ORs ranging from 0.36 to 0.50 compared with common homozygotes). Meta-analysis for XRCC3 T241M (rs861,539) had a significant small increase in risk among homozygote variants: OR (95% CI) = 1.17 (1.00-1.36). Results from this study provide evidence for associations between variants in genes in the DSBR pathway and bladder cancers risk that warrant replication in other study populations. JF - Carcinogenesis AU - Figueroa, Jonine D AU - Malats, Núria AU - Rothman, Nathaniel AU - Real, Francisco X AU - Silverman, Debra AU - Kogevinas, Manolis AU - Chanock, Stephen AU - Yeager, Meredith AU - Welch, Robert AU - Dosemeci, Mustafa AU - Tardón, Adonina AU - Serra, Consol AU - Carrato, Alfredo AU - García-Closas, Reina AU - Castaño-Vinyals, Gemma AU - García-Closas, Montserrat AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, MD, USA. figueroaj@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1788 EP - 1793 VL - 28 IS - 8 SN - 0143-3334, 0143-3334 KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Aged, 80 and over KW - Risk Factors KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - DNA Repair -- genetics KW - Genetic Variation KW - Urinary Bladder Neoplasms -- genetics KW - Genetic Predisposition to Disease KW - DNA Breaks, Double-Stranded KW - Carcinoma, Transitional Cell -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68179865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Evaluation+of+genetic+variation+in+the+double-strand+break+repair+pathway+and+bladder+cancer+risk.&rft.au=Figueroa%2C+Jonine+D%3BMalats%2C+N%C3%BAria%3BRothman%2C+Nathaniel%3BReal%2C+Francisco+X%3BSilverman%2C+Debra%3BKogevinas%2C+Manolis%3BChanock%2C+Stephen%3BYeager%2C+Meredith%3BWelch%2C+Robert%3BDosemeci%2C+Mustafa%3BTard%C3%B3n%2C+Adonina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BGarc%C3%ADa-Closas%2C+Reina%3BCasta%C3%B1o-Vinyals%2C+Gemma%3BGarc%C3%ADa-Closas%2C+Montserrat&rft.aulast=Figueroa&rft.aufirst=Jonine&rft.date=2007-08-01&rft.volume=28&rft.issue=8&rft.spage=1788&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-19 N1 - Date created - 2007-08-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hypoxic suppression of the cell cycle gene CDC25A in tumor cells. AN - 68173789; 17671423 AB - Hypoxia, a key microenvironmental factor for tumor development, not only stimulates angiogenesis and glycolysis for tumor expansion, but also induces cell cycle arrest and genetic instability for tumor progression. Several independent studies have shown hypoxic blockade of cell cycle progression at the G1/S transition, arising from the inactivation of S-phase-promoting cyclin E-CDK2 kinase complex. Despite these findings, the biochemical pathways leading to the cell cycle arrest remain poorly defined. We recently showed that hypoxic activates the expression of CDNK1A encoding the CDK2 inhibitor p21Cip1, through a novel HIF-1alpha-Myc pathway that involves Myc displacement from the CDNK1A promoter by the hypoxia-inducible transcription factor HIF-1alpha. In pursuit of further understanding of the hypoxic effects on cell cycle in tumor cells, here we report that hypoxia inhibits the expression of CDC25A, another cell cycle gene encoding a tyrosine phosphatase that maintains CDK2 activity. In accordance with the HIF-1alpha-Myc pathway, hypoxia requires HIF-1alpha for CDC25A repression, resulting in a selective displacement of an activating Myc from the CDC25A promoter without affecting a canonical Myc binding in the intron. Intriguingly, HIF-1alpha alone fails to recapitulate the hypoxic effect, indicating that HIF-1alpha is necessary but insufficient for the hypoxic repression. Taken together, our studies indicate that hypoxia inhibits cell cycle progression by controlling the expression of various cell cycle genes. JF - Cell cycle (Georgetown, Tex.) AU - Hammer, Stefanie AU - To, Kenneth K-W AU - Yoo, Young-Gun AU - Koshiji, Minori AU - Huang, L Eric AD - Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland, USA. Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 1919 EP - 1926 VL - 6 IS - 15 KW - Cell Cycle Proteins KW - 0 KW - HIF1A protein, human KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - Proto-Oncogene Proteins c-myc KW - Tumor Suppressor Protein p53 KW - Protein Kinases KW - EC 2.7.- KW - ATR protein, human KW - EC 2.7.11.1 KW - Ataxia Telangiectasia Mutated Proteins KW - Checkpoint Kinase 1 KW - Protein-Serine-Threonine Kinases KW - CDC25A protein, human KW - EC 3.1.3.48 KW - cdc25 Phosphatases KW - Index Medicus KW - Protein-Serine-Threonine Kinases -- metabolism KW - Humans KW - Transcription, Genetic -- genetics KW - Proto-Oncogene Proteins c-myc -- genetics KW - Cell Differentiation KW - Cell Line, Tumor KW - Proto-Oncogene Proteins c-myc -- metabolism KW - Cell Proliferation KW - Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism KW - Tumor Suppressor Protein p53 -- metabolism KW - Cell Cycle Proteins -- metabolism KW - Protein Kinases -- metabolism KW - Gene Expression Profiling KW - Cell Hypoxia -- genetics KW - Hypoxia-Inducible Factor 1, alpha Subunit -- genetics KW - Promoter Regions, Genetic -- genetics KW - Signal Transduction KW - Neoplasms -- pathology KW - Neoplasms -- enzymology KW - Down-Regulation -- genetics KW - cdc25 Phosphatases -- genetics KW - cdc25 Phosphatases -- metabolism KW - Neoplasms -- genetics KW - Gene Expression Regulation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68173789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+cycle+%28Georgetown%2C+Tex.%29&rft.atitle=Hypoxic+suppression+of+the+cell+cycle+gene+CDC25A+in+tumor+cells.&rft.au=Hammer%2C+Stefanie%3BTo%2C+Kenneth+K-W%3BYoo%2C+Young-Gun%3BKoshiji%2C+Minori%3BHuang%2C+L+Eric&rft.aulast=Hammer&rft.aufirst=Stefanie&rft.date=2007-08-01&rft.volume=6&rft.issue=15&rft.spage=1919&rft.isbn=&rft.btitle=&rft.title=Cell+cycle+%28Georgetown%2C+Tex.%29&rft.issn=1551-4005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-26 N1 - Date created - 2007-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Medication-related impulse control and repetitive behaviors in Parkinson disease. AN - 68161388; 17698698 AB - A range of behaviors presumed to be related to aberrant or excessive dopaminergic medications are being increasingly recognized in Parkinson disease. These behaviors are linked by their incentive- or reward-based and repetitive natures and include pathological gambling, hypersexuality, compulsive shopping, compulsive eating, hobbyism, and compulsive medication use. Such behaviors can have potentially devastating psychosocial consequences and are often hidden. Whether these behaviors are simply related to dopaminergic medications interacting with an underlying individual vulnerability or whether the primary pathological features of Parkinson disease play a role is not known. We reviewed the literature on these behaviors in Parkinson disease, including definitions, epidemiological and potential pathophysiological features, and management. The study of these behaviors allows not only improved clinical management but also greater insight into a biologically mediated complex behavioral model. JF - Archives of neurology AU - Voon, Valerie AU - Fox, Susan H AD - National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Dr, Bldg 10, Room 5S213, Bethesda, MD 20892-1428, USA. voonv@ninds.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1089 EP - 1096 VL - 64 IS - 8 SN - 0003-9942, 0003-9942 KW - Antiparkinson Agents KW - 0 KW - Dopamine Agents KW - Abridged Index Medicus KW - Index Medicus KW - Disease Susceptibility KW - Humans KW - Dopamine Agents -- adverse effects KW - Terminology as Topic KW - Prevalence KW - Disruptive, Impulse Control, and Conduct Disorders -- epidemiology KW - Disruptive, Impulse Control, and Conduct Disorders -- chemically induced KW - Antiparkinson Agents -- adverse effects KW - Disruptive, Impulse Control, and Conduct Disorders -- therapy KW - Mental Disorders -- therapy KW - Disruptive, Impulse Control, and Conduct Disorders -- physiopathology KW - Mental Disorders -- epidemiology KW - Mental Disorders -- chemically induced KW - Antiparkinson Agents -- therapeutic use KW - Parkinson Disease -- drug therapy KW - Mental Disorders -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68161388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+neurology&rft.atitle=Medication-related+impulse+control+and+repetitive+behaviors+in+Parkinson+disease.&rft.au=Voon%2C+Valerie%3BFox%2C+Susan+H&rft.aulast=Voon&rft.aufirst=Valerie&rft.date=2007-08-01&rft.volume=64&rft.issue=8&rft.spage=1089&rft.isbn=&rft.btitle=&rft.title=Archives+of+neurology&rft.issn=00039942&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-18 N1 - Date created - 2007-08-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Arsenic, internal cancers, and issues in inference from studies of low-level exposures in human populations. AN - 68157211; 17382983 AB - Epidemiologic data from regions of the world with very high levels of arsenic in drinking water (>150 microg/L) show a strong association between arsenic exposure and risk of several internal cancers. A causal interpretation of the data is warranted based on the strength and consistency of study findings. At lower levels of exposure (<100 microg/L), in the absence of unambiguous human data, extrapolation from the high-exposure studies has been used to estimate risk. Misclassification of exposure usually results in depressing observed levels of risk, and studies conducted in populations with exposures below 100 microg/L have been limited by the challenge of estimating past exposures, a critically important aspect of studying relative small increases in risk. Relatively small study size contributes to the variability of findings in most studies and makes interpretation of results all the more challenging. The effects on risk estimates of exposure misclassification and small study size under various scenarios are graphically illustrated. Efforts are underway to improve exposure assessment in a large case-control study of bladder cancer in a region of the United States with moderately elevated levels of arsenic in drinking water. JF - Toxicology and applied pharmacology AU - Cantor, Kenneth P AU - Lubin, Jay H AD - Division of Cancer Epidemiology and Genetics, 8106 EPS, National Cancer Institute, Bethesda, MD 20892-7240, USA. cantork@nih.gov Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 252 EP - 257 VL - 222 IS - 3 SN - 0041-008X, 0041-008X KW - Carcinogens KW - 0 KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Animals KW - Water Supply -- analysis KW - Urinary Bladder Neoplasms -- epidemiology KW - Humans KW - Environmental Exposure KW - Urinary Bladder Neoplasms -- chemically induced KW - Risk Assessment KW - Arsenic -- toxicity KW - Neoplasms -- chemically induced KW - Neoplasms -- epidemiology KW - Carcinogens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68157211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Arsenic%2C+internal+cancers%2C+and+issues+in+inference+from+studies+of+low-level+exposures+in+human+populations.&rft.au=Cantor%2C+Kenneth+P%3BLubin%2C+Jay+H&rft.aulast=Cantor&rft.aufirst=Kenneth&rft.date=2007-08-01&rft.volume=222&rft.issue=3&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-28 N1 - Date created - 2007-08-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Epidemiol. 2000 Mar 15;151(6):554-65 [10733037] Environ Sci Technol. 2006 Jun 1;40(11):3578-85 [16786697] Epidemiology. 2000 Nov;11(6):673-9 [11055628] Am J Epidemiol. 2001 Mar 1;153(5):411-8 [11226969] J Expo Anal Environ Epidemiol. 2002 Sep;12(5):329-34 [12198581] Environ Sci Technol. 2003 May 15;37(10):2075-83 [12785510] Am J Epidemiol. 2003 Dec 15;158(12):1193-201 [14652304] Am J Epidemiol. 2004 Feb 15;159(4):381-9 [14769642] Cancer Causes Control. 2004 Jun;15(5):465-72 [15286466] Int J Epidemiol. 2004 Oct;33(5):945-6 [15319401] Am J Epidemiol. 2004 Nov 1;160(9):853-9 [15496537] Ann Intern Med. 1972 Dec;77(6):935-7 [4509227] Can Med Assoc J. 1975 Sep 6;113(5):396-401 [125622] Arch Dermatol. 1978 Mar;114(3):378-81 [629571] Arch Dermatol. 1978 Apr;114(4):602-3 [646380] Am J Pathol. 1978 Aug;92(2):349-76 [567014] Orv Hetil. 1980 Apr 27;121(17):1009-11 [7383675] Am J Epidemiol. 1982 Dec;116(6):895-911 [7148816] Am J Epidemiol. 1989 Dec;130(6):1123-32 [2589305] Environ Health Perspect. 1992 Jul;97:259-67 [1396465] Am J Epidemiol. 1992 Aug 15;136(4):417-21 [1415161] Am J Epidemiol. 1995 Mar 15;141(6):523-30 [7900719] Epidemiology. 1996 Mar;7(2):117-24 [8834549] Am J Epidemiol. 1998 Apr 1;147(7):660-9 [9554605] Int J Epidemiol. 1998 Aug;27(4):561-9 [9758107] Environ Health Perspect. 1999 May;107(5):359-65 [10210691] Environ Health Perspect. 1999 Sep;107(9):705-10 [10464069] Cancer. 1953 Mar;6(2):347-59 [13032927] JAMA. 2004 Dec 22;292(24):2984-90 [15613666] J Occup Environ Med. 2006 Apr;48(4):376-80 [16607191] Environ Health Perspect. 2000 Jul;108(7):655-61 [10903620] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The interferon-alpha responsive gene TMEM7 suppresses cell proliferation and is downregulated in human hepatocellular carcinoma. AN - 68155448; 17693185 AB - Multiple regions on the chromosome arm 3p are frequently affected by loss of heterozygosity in human cancers. A candidate tumor suppressor gene is TMEM7, at 3p21.3, which encodes a transmembrane protein. TMEM7 is expressed specifically in the liver, and the encoded protein shares substantial sequence homology with human and mouse 28-kDa interferon-alpha (IFN-alpha) responsive protein. In investigation of the possible role of TMEM7 in development of hepatocellular carcinoma (HCC), we examined TMEM7 expression in 20 primary HCC and 18 HCC cell lines and found recurrent functional alterations. Although TMEM7 mRNA was expressed in normal hepatic cells, downregulation or inactivation of the gene was detected in 85% of primary HCC and 33% of HCC cell lines. To identify the mechanisms responsible, we examined genomic deletion and mutation, and also the effect of inhibitors of DNA methyltransferase and histone deacetylase on cells with low or no endogenous TMEM7 expression. Homozygous deletion of TMEM7 was not detected in 17 pairs of human HCC and corresponding noncancerous liver tissues, nor in any of the 18 HCC cell lines. TMEM7 mutation was not detected in the 18 HCC cell lines (low or normal TMEM7 expression). Treatment of two of six cell lines exhibiting downregulation or loss of TMEM7 with 5-aza-2'-deoxycytidine and trichostatin A yielded additive increase in TMEM7 expression, implicating aberrant DNA methylation and histone deacetylation in transcriptional silencing of this gene. Ectopic expression of TMEM7 in two TMEM7-deficient HCC lines suppressed cell proliferation, colony formation, and cell migration in vitro and reduced tumor formation in nude mice. Treatment of two highly invasive HCC cell lines with IFN-alpha for 7 days significantly increased TMEM7 expression and inhibited cell migration. These findings implicate loss of TMEM7 expression in hepatocarcinogenesis and suggest that modification of TMEM7 expression by IFN-alpha may have therapeutic relevance in a subset of HCC. JF - Cancer genetics and cytogenetics AU - Zhou, Xiaoling AU - Popescu, Nicholas C AU - Klein, George AU - Imreh, Stephan AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Building 37, Room 4128, 37 Convent Drive, MSC 4264, Bethesda, MD 20892-4255, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 6 EP - 15 VL - 177 IS - 1 SN - 0165-4608, 0165-4608 KW - Histone Deacetylase Inhibitors KW - 0 KW - Hydroxamic Acids KW - Interferon-alpha KW - trichostatin A KW - 3X2S926L3Z KW - decitabine KW - 776B62CQ27 KW - Azacitidine KW - M801H13NRU KW - Index Medicus KW - Animals KW - Azacitidine -- pharmacology KW - Azacitidine -- analogs & derivatives KW - Humans KW - Mice, Nude KW - Mice KW - Amino Acid Sequence KW - Cell Line, Tumor KW - Epigenesis, Genetic KW - Promoter Regions, Genetic KW - DNA Methylation KW - Molecular Sequence Data KW - Sequence Homology, Amino Acid KW - Hydroxamic Acids -- pharmacology KW - Immunohistochemistry KW - Male KW - Neoplasm Invasiveness -- prevention & control KW - Interferon-alpha -- pharmacology KW - Gene Silencing KW - Carcinoma, Hepatocellular -- genetics KW - Genes, Tumor Suppressor -- physiology KW - Cell Proliferation KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68155448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+genetics+and+cytogenetics&rft.atitle=The+interferon-alpha+responsive+gene+TMEM7+suppresses+cell+proliferation+and+is+downregulated+in+human+hepatocellular+carcinoma.&rft.au=Zhou%2C+Xiaoling%3BPopescu%2C+Nicholas+C%3BKlein%2C+George%3BImreh%2C+Stephan&rft.aulast=Zhou&rft.aufirst=Xiaoling&rft.date=2007-08-01&rft.volume=177&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Cancer+genetics+and+cytogenetics&rft.issn=01654608&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-04 N1 - Date created - 2007-08-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Lett. 2003 Mar 10;191(2):155-64 [12618328] BMC Cancer. 2002 Nov 15;2:29 [12433278] Hepatology. 2003 Apr;37(4):739-41 [12668963] Hepatology. 2003 Apr;37(4):852-61 [12668978] Am J Pathol. 2003 Sep;163(3):1101-7 [12937151] Genes Chromosomes Cancer. 2003 Dec;38(4):307-21 [14566849] N Engl J Med. 2003 Nov 20;349(21):2042-54 [14627790] J Interferon Cytokine Res. 2003 Dec;23(12):745-56 [14769151] Oncogene. 2004 Feb 12;23(6):1308-13 [14647417] Cancer Res. 2000 Feb 15;60(4):1049-53 [10706123] Curr Opin Immunol. 2000 Aug;12(4):419-24 [10899033] Lab Invest. 2001 Apr;81(4):613-27 [11304581] Cancer Res. 2001 Nov 15;61(22):8094-9 [11719434] Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14763-5 [11752421] Nat Rev Cancer. 2001 Dec;1(3):194-202 [11902574] Eur J Hum Genet. 2002 Jan;10(1):52-61 [11896456] Nat Rev Genet. 2002 Jun;3(6):415-28 [12042769] Nat Genet. 2002 Aug;31(4):339-46 [12149612] Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15584-9 [12438687] Nature. 2002 Dec 5;420(6915):563-73 [12466851] Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903 [12477932] Oncogene. 2003 Jan 23;22(3):445-50 [12545165] Oncogene. 2004 Feb 19;23(7):1405-11 [14661059] Int J Oncol. 2004 Apr;24(4):837-45 [15010820] N Engl J Med. 1999 Mar 11;340(10):745-50 [10072408] Hepatology. 1999 Apr;29(4):1208-14 [10094966] Biofactors. 2004;21(1-4):69-72 [15630172] Int J Cancer. 2005 Jul 10;115(5):684-9 [15704097] Clin Cancer Res. 2006 Mar 1;12(5):1412-9 [16533763] Am J Pathol. 2006 Apr;168(4):1375-84 [16565510] Cancer Res. 2006 Jun 15;66(12):6361-9 [16778214] Oncogene. 2003 Mar 27;22(12):1866-71 [12660822] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Molecular targets for nutritional preemption of cancer. AN - 68152974; 17691899 AB - Malignant cells are characterized by alterations in multiple signaling pathways that promote proliferation, inhibit apoptosis, promote angiogenesis in the case of solid tumors, and enable cancer cells to invade and migrate through tissues. A variety of foods and their bioactive dietary constituents appear to have merit in reducing cancer risk and modifying tumor behavior. All of the major signaling pathways, which are deregulated in cancer, and which serve as potential targets for cancer prevention, have been reported to respond to one or more dietary components. Herein, we provide a brief overview of the importance of diet as a modifier of carcinogen metabolism, DNA repair, cell proliferation, apoptosis, inflammation, immunity, differentiation, angiogenesis, hormonal regulation and cellular energetics. This special issue of Current Cancer Drug Targets provides a collection of articles from researchers who are actively involved in examining the role of dietary components in cancer prevention and therapy. The remaining articles in this series provide more details about the specifics about the importance of these processes during carcinogenesis and proof-of-principal about the modifying capabilities of food patterns, specific foods and individual bioactive food components. JF - Current cancer drug targets AU - Davis, Cindy D AU - Milner, John A AD - Nutritional Science Research Group, National Cancer Institute, Rockville, MD 20892, USA. davisci@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 410 EP - 415 VL - 7 IS - 5 KW - Index Medicus KW - Signal Transduction -- physiology KW - Animals KW - Humans KW - Signal Transduction -- genetics KW - Signal Transduction -- immunology KW - Diet -- methods KW - Neoplasms -- pathology KW - Neoplasms -- prevention & control KW - Neoplasms -- diet therapy KW - Neoplasms -- genetics KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68152974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+cancer+drug+targets&rft.atitle=Molecular+targets+for+nutritional+preemption+of+cancer.&rft.au=Davis%2C+Cindy+D%3BMilner%2C+John+A&rft.aulast=Davis&rft.aufirst=Cindy&rft.date=2007-08-01&rft.volume=7&rft.issue=5&rft.spage=410&rft.isbn=&rft.btitle=&rft.title=Current+cancer+drug+targets&rft.issn=1873-5576&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-10 N1 - Date created - 2007-08-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma. AN - 68147812; 17684125 AB - alpha-Methylacyl-CoA racemase (AMACR), an enzyme involved in oxidation of branched chain fatty acids and cholesterol metabolites, as well as ibuprofen metabolism, is overexpressed in colorectal adenomas and cancer. AMACR gene variants have been associated with hereditary prostate cancer, but no studies have evaluated their etiologic role in colorectal carcinogenesis. We conducted a case-control study of 725 advanced distal colorectal adenoma cases and 729 frequency-matched controls from the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Seven AMACR polymorphisms were genotyped. Unconditional logistic regression models were used to evaluate the associations adjusting for age at randomization and gender. The 201L allele of S201L [TT versus CC: odds ratio (OR), 1.74; 95% confidence interval (95% CI), 1.15-2.62; TC versus CC: OR, 1.17; 95% CI, 0.93-1.49] and the 277E allele of K277E (GG versus AA: OR, 1.66; 95% CI, 1.03-2.68; GA versus AA: OR, 1.21; 95% CI, 0.96-1.53) were associated with increased risk of advanced distal colorectal adenoma (both P(trend) or =110% of the prescribed dose and an 8% increase in the target volume receiving > or =95% of the prescribed dose. Although target homogeneity was improved, the maximum dose delivered in the paraspinal muscles was increased by approximately 8.5% with spinal IMRT compared to the PA technique. Follow-up evaluations revealed no unexpected toxicity associated with the IMRT technique. A new technique of spine IMRT is presented in combination with a quality assurance method. This method improves target dose uniformity compared to the conventional CSI technique. Longer follow-up will be required to determine any benefit with regard to toxicity and disease control. JF - International journal of radiation oncology, biology, physics AU - Pai Panandiker, Atmaram AU - Ning, Holly AU - Likhacheva, Anna AU - Ullman, Karen AU - Arora, Barbara AU - Ondos, John AU - Karimpour, Shervin AU - Packer, Roger AU - Miller, Robert AU - Citrin, Deborah AD - Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 1402 EP - 1409 VL - 68 IS - 5 SN - 0360-3016, 0360-3016 KW - Index Medicus KW - Spine -- radiation effects KW - Spinal Cord -- radiation effects KW - Radiotherapy Dosage KW - Humans KW - Adult KW - Child KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Radiotherapy, Intensity-Modulated -- standards KW - Supine Position KW - Radiotherapy, Intensity-Modulated -- methods KW - Brain Neoplasms -- radiotherapy KW - Spinal Neoplasms -- radiotherapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68127431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=Craniospinal+irradiation+with+spinal+IMRT+to+improve+target+homogeneity.&rft.au=Pai+Panandiker%2C+Atmaram%3BNing%2C+Holly%3BLikhacheva%2C+Anna%3BUllman%2C+Karen%3BArora%2C+Barbara%3BOndos%2C+John%3BKarimpour%2C+Shervin%3BPacker%2C+Roger%3BMiller%2C+Robert%3BCitrin%2C+Deborah&rft.aulast=Pai+Panandiker&rft.aufirst=Atmaram&rft.date=2007-08-01&rft.volume=68&rft.issue=5&rft.spage=1402&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-09 N1 - Date created - 2007-08-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer J. 2004 Nov-Dec;10(6):386-90 [15701271] Int J Radiat Oncol Biol Phys. 2006 May 1;65(1):1-7 [16618572] Int J Radiat Oncol Biol Phys. 2005 Oct 1;63(2):362-72 [16168831] Br J Radiol. 2005 Jun;78(930):548-52 [15900062] Int J Radiat Oncol Biol Phys. 1999 Aug 1;45(1):137-45 [10477017] Radiographics. 1999 Jul-Aug;19(4):873-85 [10464796] Int J Radiat Oncol Biol Phys. 2001 Jan 1;49(1):261-4 [11163523] J Appl Clin Med Phys. 2002 Autumn;3(4):310-6 [12383051] Int J Radiat Oncol Biol Phys. 2003 Jan 1;55(1):245-60 [12504059] Med Dosim. 2003 Spring;28(1):35-8 [12747617] Int J Radiat Oncol Biol Phys. 2004 Mar 1;58(3):727-34 [14967427] Radiology. 1975 Jan;114(1):155-62 [813276] Int J Radiat Oncol Biol Phys. 1997 Mar 15;37(5):1187-92 [9169830] Int J Radiat Oncol Biol Phys. 1999 Apr 1;44(1):81-4 [10219798] Eur J Cancer. 1998 Sep;34(10):1592-7 [9893634] Radiographics. 1998 Sep-Oct;18(5):1125-36; quiz 1242-3 [9747611] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis. AN - 68119705; 17559148 AB - A pilot study of a 48-week course of pioglitazone demonstrated significant improvements in the biochemical and histological features of nonalcoholic steatohepatitis (NASH). The aim of the study was to assess the effects of stopping pioglitazone. Twenty-one patients with NASH were treated with pioglitazone (30 mg/day) for 48 weeks and underwent baseline and end-of-treatment evaluation including liver biopsy. Thirteen patients were followed for at least 48 weeks after stopping therapy and 9 underwent repeat liver biopsy. Statistical comparisons were made to evaluate whether discontinuation of pioglitazone resulted in a reversal of improvements seen on therapy. Stopping pioglitazone was associated with subsequent elevation in serum alanine aminotransferase levels (from 34 +/- 13 to 70 +/- 39 IU/l), decrease in adiponectin (from 9.7 +/- 9.1 to 5.1 +/- 4.5 microg/ml), worsening insulin sensitivity (HOMA Index: from 2.9 +/- 1.8 to 5.5 +/- 5.4), and increase in total hepatic fat (from 30% +/- 32% to 71% +/- 33%) despite no change in average body weight compared to the end of treatment. Repeat liver biopsy in 9 patients revealed significant worsening of parenchymal inflammation (from 1.2 +/- 0.7 to 2.9 +/- 1.1) and steatosis (from 0.9 +/- 0.6 to 2.1 +/- 1.3) but no change in fibrosis (from 1.1 +/- 1.2 to 1.2 +/- 1.3). NASH was again present on liver biopsy in 7 patients. These findings suggest that long-term therapy with pioglitazone may be necessary to maintain improvements in disease activity in patients with NASH, although weight gain during treatment may ultimately limit its beneficial effects. JF - Hepatology (Baltimore, Md.) AU - Lutchman, Glen AU - Modi, Apurva AU - Kleiner, David E AU - Promrat, Kittichai AU - Heller, Theo AU - Ghany, Marc AU - Borg, Brian AU - Loomba, Rohit AU - Liang, T Jake AU - Premkumar, Ahalya AU - Hoofnagle, Jay H AD - Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 424 EP - 429 VL - 46 IS - 2 SN - 0270-9139, 0270-9139 KW - PPAR gamma KW - 0 KW - Thiazolidinediones KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - pioglitazone KW - X4OV71U42S KW - Index Medicus KW - Weight Gain -- drug effects KW - Aspartate Aminotransferases -- blood KW - Liver -- pathology KW - Alanine Transaminase -- blood KW - Humans KW - Adult KW - Middle Aged KW - Insulin Resistance KW - Male KW - Female KW - Fatty Liver -- drug therapy KW - Fatty Liver -- metabolism KW - Thiazolidinediones -- adverse effects KW - Fatty Liver -- pathology KW - Thiazolidinediones -- therapeutic use KW - PPAR gamma -- agonists UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68119705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=The+effects+of+discontinuing+pioglitazone+in+patients+with+nonalcoholic+steatohepatitis.&rft.au=Lutchman%2C+Glen%3BModi%2C+Apurva%3BKleiner%2C+David+E%3BPromrat%2C+Kittichai%3BHeller%2C+Theo%3BGhany%2C+Marc%3BBorg%2C+Brian%3BLoomba%2C+Rohit%3BLiang%2C+T+Jake%3BPremkumar%2C+Ahalya%3BHoofnagle%2C+Jay+H&rft.aulast=Lutchman&rft.aufirst=Glen&rft.date=2007-08-01&rft.volume=46&rft.issue=2&rft.spage=424&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-30 N1 - Date created - 2007-08-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Hepatology. 2007 Aug;46(2):285-7 [17661403] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In vitro models of TGF-beta-induced fibrosis suitable for high-throughput screening of antifibrotic agents. AN - 68109749; 17494090 AB - Progressive fibrosis is a cause of progressive organ dysfunction. Lack of quantitative in vitro models of fibrosis accounts, at least partially, for the slow progress in developing effective antifibrotic drugs. Here, we report two complementary in vitro models of fibrosis suitable for high-throughput screening. We found that, in mesangial cells and renal fibroblasts grown in eight-well chamber slides, transforming growth factor-beta1 (TGF-beta1) disrupted the cell monolayer and induced cell migration into nodules in a dose-, time- and Smad3-dependent manner. The nodules contained increased interstitial collagens and showed an increased collagen I:IV ratio. Nodules are likely a biological consequence of TGF-beta1-induced matrix overexpression since they were mimicked by addition of collagen I to the cell culture medium. TGF-beta1-induced nodule formation was inhibited by vacuum ionized gas treatment of the plate surface. This blockage was further enhanced by precoating plates with matrix proteins but was prevented, at least in part, by poly-l-lysine (PLL). We have established two cell-based models of TGF-beta-induced fibrogenesis, using mesangial cells or fibroblasts cultured in matrix protein or PLL-coated 96-well plates, on which TGF-beta1-induced two-dimensional matrix accumulation, three-dimensional nodule formation, and monolayer disruption can be quantitated either spectrophotometrically or by using a colony counter, respectively. As a proof of principle, chemical inhibitors of Alk5 and the antifibrotic compound tranilast were shown to have inhibitory activities in both assays. JF - American journal of physiology. Renal physiology AU - Xu, Qihe AU - Norman, Jill T AU - Shrivastav, Shashi AU - Lucio-Cazana, Javier AU - Kopp, Jeffrey B AD - Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Disases, National Institutes of Health, Bethesda, MD 20892-1268, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - F631 EP - F640 VL - 293 IS - 2 SN - 1931-857X, 1931-857X KW - Coloring Agents KW - 0 KW - Smad3 Protein KW - Transforming Growth Factor beta KW - Polylysine KW - 25104-18-1 KW - Index Medicus KW - Animals KW - Fibroblasts -- drug effects KW - Humans KW - Mice KW - Mesenchymal Stromal Cells -- drug effects KW - Epithelial Cells -- drug effects KW - Fibroblasts -- pathology KW - Polylysine -- pharmacology KW - Cells, Cultured KW - Glomerular Mesangium -- cytology KW - Glomerular Mesangium -- drug effects KW - Kidney -- cytology KW - Dogs KW - Microscopy, Electron KW - Smad3 Protein -- physiology KW - Image Processing, Computer-Assisted KW - Drug Evaluation, Preclinical KW - Cell Line KW - Fibrosis -- pathology KW - Fibrosis -- chemically induced KW - Transforming Growth Factor beta -- toxicity KW - Fibrosis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68109749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Renal+physiology&rft.atitle=In+vitro+models+of+TGF-beta-induced+fibrosis+suitable+for+high-throughput+screening+of+antifibrotic+agents.&rft.au=Xu%2C+Qihe%3BNorman%2C+Jill+T%3BShrivastav%2C+Shashi%3BLucio-Cazana%2C+Javier%3BKopp%2C+Jeffrey+B&rft.aulast=Xu&rft.aufirst=Qihe&rft.date=2007-08-01&rft.volume=293&rft.issue=2&rft.spage=F631&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Renal+physiology&rft.issn=1931857X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-26 N1 - Date created - 2007-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The impact of sex and sex hormones on lung physiology and disease: lessons from animal studies. AN - 68109628; 17575008 AB - Numerous animal studies have revealed significant effects of sex and sex hormones on normal lung development, lung physiology, and various lung diseases. The primary goal of this review is to summarize knowledge to date on the effects of sex and sex hormones on lung development, physiology, and disease in animals. Specific emphasis will be placed on fibrosis, allergic airway disease, acute lung injury models, respiratory infection, and lung toxicology studies. JF - American journal of physiology. Lung cellular and molecular physiology AU - Carey, Michelle A AU - Card, Jeffrey W AU - Voltz, James W AU - Germolec, Dori R AU - Korach, Kenneth S AU - Zeldin, Darryl C AD - National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - L272 EP - L278 VL - 293 IS - 2 SN - 1040-0605, 1040-0605 KW - Androgens KW - 0 KW - Estrogens KW - Index Medicus KW - Animals KW - Sex Characteristics KW - Androgens -- physiology KW - Lung Diseases -- physiopathology KW - Estrogens -- physiology KW - Lung -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68109628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Lung+cellular+and+molecular+physiology&rft.atitle=The+impact+of+sex+and+sex+hormones+on+lung+physiology+and+disease%3A+lessons+from+animal+studies.&rft.au=Carey%2C+Michelle+A%3BCard%2C+Jeffrey+W%3BVoltz%2C+James+W%3BGermolec%2C+Dori+R%3BKorach%2C+Kenneth+S%3BZeldin%2C+Darryl+C&rft.aulast=Carey&rft.aufirst=Michelle&rft.date=2007-08-01&rft.volume=293&rft.issue=2&rft.spage=L272&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Lung+cellular+and+molecular+physiology&rft.issn=10400605&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-26 N1 - Date created - 2007-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of aromatic and charged ectodomain residues in the P2X(4) receptor functions. AN - 68108105; 17663752 AB - The localization of ATP binding site(s) at P2X receptors and the molecular rearrangements associated with opening and closing of channels are still not well understood. At P2X(4) receptor, substitution of the K67, F185, K190, F230, R278, D280, R295, and K313 ectodomain residues with alanine generated low or non-responsive mutants, whereas the F294A mutant was functional. The loss of receptor function was also observed in K67R, R295K, and K313R mutants, but not in F185W, K190R, F230W, R278K, and D280E mutants. To examine whether the loss of function reflects decreased sensitivity of mutants for ATP, we treated cells with ivermectin, an antiparasitic agent that enhances responsiveness of P2X(4)R. In the presence of ivermectin, all low or non-responsive mutants responded to ATP in a dose-dependent manner, with the EC(50) values for ATP of about 1, 2, 4, 20, 60, 125, 270, 420, 1000 and 2300 micromol/L at D280A, R278A, F185A, K190A, R295K, K313R, R295A, K313A, K67A and K67R mutants, respectively. These results indicate that lysines 67 and 313 and arginine 295 play a critical role in forming the proper three-dimensional structure of P2X(4)R for agonist binding and/or channel gating. JF - Journal of neurochemistry AU - Zemkova, Hana AU - Yan, Zonghe AU - Liang, Zhaodong AU - Jelinkova, Irena AU - Tomic, Melanija AU - Stojilkovic, Stanko S AD - Section on Cellular Signaling, NICHD, National Institutes of Health, Bethesda, Maryland 20892-4510, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1139 EP - 1150 VL - 102 IS - 4 SN - 0022-3042, 0022-3042 KW - Amino Acids, Aromatic KW - 0 KW - P2RX4 protein, human KW - P2rx4 protein, mouse KW - Receptors, Purinergic P2 KW - Receptors, Purinergic P2X4 KW - Gonadotropin-Releasing Hormone KW - 33515-09-2 KW - Ivermectin KW - 70288-86-7 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Index Medicus KW - Animals KW - Membrane Potentials -- radiation effects KW - Neurons -- metabolism KW - Ivermectin -- pharmacology KW - Dose-Response Relationship, Drug KW - Humans KW - Hypothalamus -- cytology KW - Mice KW - Structure-Activity Relationship KW - Gonadotropin-Releasing Hormone -- metabolism KW - Patch-Clamp Techniques KW - Transfection KW - Protein Binding -- drug effects KW - Mutagenesis, Site-Directed -- methods KW - Binding Sites -- drug effects KW - Membrane Potentials -- drug effects KW - Cell Line, Transformed KW - Adenosine Triphosphate -- pharmacology KW - Receptors, Purinergic P2 -- chemistry KW - Amino Acids, Aromatic -- physiology KW - Receptors, Purinergic P2 -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68108105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Role+of+aromatic+and+charged+ectodomain+residues+in+the+P2X%284%29+receptor+functions.&rft.au=Zemkova%2C+Hana%3BYan%2C+Zonghe%3BLiang%2C+Zhaodong%3BJelinkova%2C+Irena%3BTomic%2C+Melanija%3BStojilkovic%2C+Stanko+S&rft.aulast=Zemkova&rft.aufirst=Hana&rft.date=2007-08-01&rft.volume=102&rft.issue=4&rft.spage=1139&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-04 N1 - Date created - 2007-07-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A proposed COX-2 and PGE(2) receptor interaction in UV-exposed mouse skin. AN - 68108047; 17570497 AB - The cyclooxygenases (COX-1 and COX-2) and the prostaglandins (PGs) they generate play a major role in the skin's response to sunlight. Sunlight, especially the ultraviolet B (UVB) component, induces COX-2 and increases PG levels. However, PGs can have both beneficial and adverse cutaneous effects. To elucidate the roles of the COXs and the PGs they generate in response to UVB exposure, experiments with the COX-1- and COX-2-deficient mice have provided insight into the specific roles of each isoform. Furthermore, because PGE(2) is the major PG produced following UV exposure and PGE(2) manifests its biological activity via four membrane receptors (EP1, EP2, EP3, EP4), elucidating contributions of these receptors is essential for understanding the roles of PGs in UVB-induced effects. In this review, we summarize recent findings from the COX-deficient mice showing how COX-2 generated PGE(2) acting via the receptors EP2 and EP4 could contribute to short term beneficial, but also contribute to long-term carcinogenic effects in response to UVB exposure. JF - Molecular carcinogenesis AU - Chun, Kyung-Soo AU - Langenbach, Robert AD - Laboratory of Molecular Carcinogenesis, NIEHS, NIH, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 699 EP - 704 VL - 46 IS - 8 SN - 0899-1987, 0899-1987 KW - Receptors, Prostaglandin E KW - 0 KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - Index Medicus KW - Animals KW - Mice KW - Receptors, Prostaglandin E -- metabolism KW - Ultraviolet Rays KW - Skin -- radiation effects KW - Skin -- enzymology KW - Cyclooxygenase 2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68108047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=A+proposed+COX-2+and+PGE%282%29+receptor+interaction+in+UV-exposed+mouse+skin.&rft.au=Chun%2C+Kyung-Soo%3BLangenbach%2C+Robert&rft.aulast=Chun&rft.aufirst=Kyung-Soo&rft.date=2007-08-01&rft.volume=46&rft.issue=8&rft.spage=699&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=08991987&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-18 N1 - Date created - 2007-07-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Site matters: multisite randomized trial of motivational enhancement therapy in community drug abuse clinics. AN - 68107630; 17663610 AB - The effectiveness of motivational enhancement therapy (MET) in comparison with counseling as usual (CAU) for increasing retention and reducing substance use was evaluated in a multisite randomized clinical trial. Participants were 461 outpatients treated by 31 therapists within 1 of 5 outpatient substance abuse programs. There were no retention differences between the 2 brief intervention conditions. Although both 3-session interventions resulted in reductions in substance use during the 4-week therapy phase, MET resulted in sustained reductions during the subsequent 12 weeks whereas CAU was associated with significant increases in substance use over this follow-up period. This finding was complicated by program site main effects and higher level interactions. MET resulted in more sustained substance use reductions than CAU among primary alcohol users, but no difference was found for primary drug users. An independent evaluation of session audiotapes indicated that MET and CAU were highly and comparably discriminable across sites. JF - Journal of consulting and clinical psychology AU - Ball, Samuel A AU - Martino, Steve AU - Nich, Charla AU - Frankforter, Tami L AU - Van Horn, Deborah AU - Crits-Christoph, Paul AU - Woody, George E AU - Obert, Jeanne L AU - Farentinos, Christiane AU - Carroll, Kathleen M AU - National Institute on Drug Abuse Clinical Trials Network AD - Department of Psychiatry, Yale University School of Medicine, APT Foundation, New Haven, CT 06511, USA. samuel.ball@yale.edu ; National Institute on Drug Abuse Clinical Trials Network Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 556 EP - 567 VL - 75 IS - 4 SN - 0022-006X, 0022-006X KW - Index Medicus KW - Humans KW - Adult KW - Follow-Up Studies KW - Retention (Psychology) KW - Male KW - Female KW - Motivation KW - Community Mental Health Services -- utilization KW - Ambulatory Care Facilities KW - Substance-Related Disorders -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68107630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+consulting+and+clinical+psychology&rft.atitle=Site+matters%3A+multisite+randomized+trial+of+motivational+enhancement+therapy+in+community+drug+abuse+clinics.&rft.au=Ball%2C+Samuel+A%3BMartino%2C+Steve%3BNich%2C+Charla%3BFrankforter%2C+Tami+L%3BVan+Horn%2C+Deborah%3BCrits-Christoph%2C+Paul%3BWoody%2C+George+E%3BObert%2C+Jeanne+L%3BFarentinos%2C+Christiane%3BCarroll%2C+Kathleen+M%3BNational+Institute+on+Drug+Abuse+Clinical+Trials+Network&rft.aulast=Ball&rft.aufirst=Samuel&rft.date=2007-08-01&rft.volume=75&rft.issue=4&rft.spage=556&rft.isbn=&rft.btitle=&rft.title=Journal+of+consulting+and+clinical+psychology&rft.issn=0022006X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-25 N1 - Date created - 2007-07-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Drug Alcohol Depend. 2000 Jan 1;57(3):225-38 [10661673] Drug Alcohol Depend. 2000 Apr 1;59(1):63-75 [10706976] J Consult Clin Psychol. 2000 Feb;68(1):134-44 [10710848] J Consult Clin Psychol. 2000 Oct;68(5):898-908 [11068976] Addiction. 2001 Aug;96(8):1149-60 [11487421] J Consult Clin Psychol. 2001 Oct;69(5):858-62 [11680565] Addiction. 2001 Dec;96(12):1725-42 [11784466] J Subst Abuse Treat. 2002 Dec;23(4):309-18 [12495792] J Subst Abuse Treat. 2003 Jan;24(1):51-7 [12646330] J Subst Abuse Treat. 2003 Apr;24(3):183-96 [12810139] J Consult Clin Psychol. 2003 Aug;71(4):754-63 [12924680] J Consult Clin Psychol. 2003 Oct;71(5):843-61 [14516234] Psychol Methods. 2003 Dec;8(4):518-23 [14664686] Drug Alcohol Depend. 2004 Jan 7;73(1):99-106 [14687964] Arch Gen Psychiatry. 2004 Mar;61(3):264-72 [14993114] Addiction. 2004 Jul;99(7):862-74 [15200582] J Consult Clin Psychol. 2004 Jun;72(3):455-66 [15279529] J Nerv Ment Dis. 1992 Feb;180(2):101-10 [1737971] J Stud Alcohol Suppl. 1994 Dec;12:149-55 [7722991] J Stud Alcohol Suppl. 1994 Dec;12:70-5 [7723001] Addiction. 1995 Mar;90(3):415-24 [7735025] J Stud Alcohol. 1997 Jan;58(1):7-29 [8979210] Arch Gen Psychiatry. 1997 Aug;54(8):721-6 [9283507] Public Health Rep. 1998 Jun;113 Suppl 1:116-28 [9722817] J Consult Clin Psychol. 2004 Dec;72(6):1050-62 [15612851] BMJ. 2005 Sep 10;331(7516):541 [16150764] Drug Alcohol Depend. 2006 Feb 28;81(3):301-12 [16169159] Addiction. 2006 Oct;101(10):1479-92 [16968350] Drug Alcohol Depend. 2007 Mar 16;87(2-3):107-18 [17023123] Annu Rev Clin Psychol. 2005;1:91-111 [17716083] Erratum In: J Consult Clin Psychol. 2009 Apr;77(2):336 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Impact of continuous versus intermittent CS-UCS pairing on human brain activation during Pavlovian fear conditioning. AN - 68106364; 17663589 AB - During Pavlovian fear conditioning a conditioned stimulus (CS) is repeatedly paired with an aversive unconditioned stimulus (UCS). In many studies the CS and UCS are paired on every trial, whereas in others the CS and UCS are paired intermittently. To better understand the influence of the CS-UCS pairing rate on brain activity, the experimenters presented continuously, intermittently, and non-paired CSs during fear conditioning. Amygdala, anterior cingulate, and fusiform gyrus activity increased linearly with the CS-UCS pairing rate. In contrast, insula and left dorsolateral prefrontal cortex responses were larger during intermittently paired CS presentations relative to continuously and non-paired CSs. These results demonstrate two distinct patterns of activity in disparate brain regions. Amygdala, anterior cingulate, and fusiform gyrus activity paralleled the CS-UCS pairing rate, whereas the insula and dorsolateral prefrontal cortex appeared to respond to the uncertainty inherent in intermittent CS-UCS pairing procedures. These findings may further clarify the role of these brain regions in Pavlovian fear conditioning. ((c) 2007 APA, all rights reserved). JF - Behavioral neuroscience AU - Dunsmoor, Joseph E AU - Bandettini, Peter A AU - Knight, David C AD - Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, 10 Center Drive, Bethesda, MD 20892, USA. Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 635 EP - 642 VL - 121 IS - 4 SN - 0735-7044, 0735-7044 KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Analysis of Variance KW - Area Under Curve KW - Humans KW - Dose-Response Relationship, Radiation KW - Brain Mapping KW - Magnetic Resonance Imaging -- methods KW - Oxygen -- blood KW - Adult KW - Middle Aged KW - Acoustic Stimulation KW - Time Factors KW - Image Processing, Computer-Assisted KW - Male KW - Female KW - Functional Laterality KW - Galvanic Skin Response -- physiology KW - Conditioning, Classical -- physiology KW - Fear KW - Brain -- blood supply KW - Brain -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68106364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+neuroscience&rft.atitle=Impact+of+continuous+versus+intermittent+CS-UCS+pairing+on+human+brain+activation+during+Pavlovian+fear+conditioning.&rft.au=Dunsmoor%2C+Joseph+E%3BBandettini%2C+Peter+A%3BKnight%2C+David+C&rft.aulast=Dunsmoor&rft.aufirst=Joseph&rft.date=2007-08-01&rft.volume=121&rft.issue=4&rft.spage=635&rft.isbn=&rft.btitle=&rft.title=Behavioral+neuroscience&rft.issn=07357044&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-12 N1 - Date created - 2007-07-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A key role for corticotropin-releasing factor in alcohol dependence. AN - 68106186; 17629579 AB - Recent data indicate that alcohol dependence induces long-term neuroadaptations that recruit a negative emotional state. This leads to excessive alcohol ingestion motivated by relief of negative emotionality. A key mechanism in this transition to negative reinforcement is a recruitment of corticotropin-releasing factor (CRF) signaling within the amygdala. Long term upregulation of CRF(1) receptors is observed in the amygdala following a history of dependence, and CRF antagonists selectively block emotionality, excessive alcohol drinking and stress-induced reinstatement of alcohol-seeking in post-dependent animals. Innate upregulation of CRF(1) receptor expression mimics the post-dependent phenotype, both with regard to emotional responses and ethanol self-administration. Therefore, the CRF system is emerging as a key element of the neuroadaptive changes driving alcoholism and as a major target for its treatment. JF - Trends in neurosciences AU - Heilig, Markus AU - Koob, George F AD - Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism (NIAAA), NIH, 10 Center Dr., 1/5334, Bethesda, MD 20892, USA. markus.heilig@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 399 EP - 406 VL - 30 IS - 8 SN - 0166-2236, 0166-2236 KW - Ethanol KW - 3K9958V90M KW - Corticotropin-Releasing Hormone KW - 9015-71-8 KW - Index Medicus KW - Animals KW - Adaptation, Physiological -- drug effects KW - Reward KW - Ethanol -- pharmacology KW - Humans KW - Amygdala -- metabolism KW - Affect -- drug effects KW - Affect -- physiology KW - Alcohol-Related Disorders -- metabolism KW - Behavior, Addictive -- metabolism KW - Corticotropin-Releasing Hormone -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68106186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+neurosciences&rft.atitle=A+key+role+for+corticotropin-releasing+factor+in+alcohol+dependence.&rft.au=Heilig%2C+Markus%3BKoob%2C+George+F&rft.aulast=Heilig&rft.aufirst=Markus&rft.date=2007-08-01&rft.volume=30&rft.issue=8&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=Trends+in+neurosciences&rft.issn=01662236&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-06 N1 - Date created - 2007-07-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuroscience. 2006;138(1):235-43 [16359808] Alcohol Clin Exp Res. 2006 May;30(5):908-15 [16634861] Mol Psychiatry. 2006 Jun;11(6):594-602 [16550213] Pharmacol Ther. 2006 Sep;111(3):855-76 [16545872] Addict Biol. 2006 Sep;11(3-4):339-55 [16961763] Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15236-41 [17015825] Alcohol Clin Exp Res. 2002 Aug;26(8):1259-68 [12198403] J Neurosci. 2002 Sep 15;22(18):7844-9 [12223536] J Neurosci. 2002 Sep 15;22(18):7856-61 [12223538] Alcohol Clin Exp Res. 2002 Oct;26(10):1494-501 [12394282] Lancet. 2002 Nov 2;360(9343):1347-60 [12423980] Alcohol Alcohol. 2003 Jan-Feb;38(1):35-9 [12554605] Alcohol. 2003 Feb;29(2):55-60 [12782246] Neurosci Biobehav Rev. 2003 May;27(3):189-97 [12788332] Psychopharmacology (Berl). 2003 Jul;168(1-2):3-20 [12402102] J Stud Alcohol. 2003 Jul;64(4):445-9 [12921185] Pharmacol Biochem Behav. 2004 Feb;77(2):405-13 [14751471] J Neurosci. 2004 Feb 18;24(7):1551-60 [14973230] Alcohol. 2004 Feb;32(2):101-11 [15163561] Trends Mol Med. 2004 Aug;10(8):409-15 [15310462] Pediatrics. 2004 Sep;114(3):714-9 [15342844] J Stud Alcohol. 2004 Jul;65(4):477-88 [15378804] J Pharmacol Exp Ther. 2004 Nov;311(2):427-40 [15297468] Science. 1981 Sep 18;213(4514):1394-7 [6267699] Neuroendocrinology. 1983;36(3):165-86 [6601247] Science. 1984 Sep 21;225(4668):1326-34 [6147896] Am Psychol. 1986 Jul;41(7):765-82 [3527003] Psychopharmacology (Berl). 1991;103(2):227-32 [2027923] Brain Res. 1993 Mar 5;605(1):25-32 [8467387] Trends Neurosci. 1994 Feb;17(2):80-5 [7512773] J Neurosci. 1995 Aug;15(8):5439-47 [7643193] Neuron. 1996 Mar;16(3):675-86 [8785064] Psychopharmacology (Berl). 1998 Jan;135(2):169-74 [9497022] Neuropsychopharmacology. 1999 May;20(5):471-9 [10192827] Acta Psychiatr Neurol Scand Suppl. 1951;70:1-283 [14837769] Alcohol Clin Exp Res. 2004 Nov;28(11):1676-82 [15547454] Alcohol Clin Exp Res. 2004 Dec;28(12):1829-38 [15608599] Neurosci Lett. 2005 Feb 28;375(2):129-33 [15670655] Nat Rev Drug Discov. 2005 Feb;4(2):131-44 [15665858] Psychopharmacology (Berl). 2005 Apr;178(4):367-80 [15765253] Psychopharmacology (Berl). 2005 May;179(2):366-73 [15551068] Alcohol Clin Exp Res. 2005 Apr;29(4):584-90 [15834223] Behav Brain Res. 2005 Jun 3;161(1):133-40 [15904720] J Neurosci. 2005 Jun 1;25(22):5389-96 [15930388] Nat Rev Genet. 2005 Jul;6(7):521-32 [15995696] Neuropsychopharmacology. 2005 Sep;30(9):1662-9 [15726114] Nat Neurosci. 2005 Nov;8(11):1431-6 [16251982] Nat Neurosci. 2005 Nov;8(11):1442-4 [16251985] Addict Biol. 2005 Dec;10(4):309-19 [16318951] EXS. 2006;(95):183-92 [16383007] Neuropsychopharmacology. 2000 Feb;22(2):108-24 [10649824] Neuropsychopharmacology. 2000 Jun;22(6):581-94 [10788758] Psychopharmacology (Berl). 2000 Jun;150(3):317-24 [10923760] Neuropsychopharmacology. 2001 Feb;24(2):97-129 [11120394] J Neurosci. 2006 Nov 1;26(44):11324-32 [17079660] Biol Psychiatry. 2007 Jan 1;61(1):78-86 [16876134] J Neurosci. 2007 Mar 7;27(10):2718-26 [17344409] Addict Biol. 2007 Mar;12(1):30-4 [17407495] Biol Psychiatry. 2008 Jan 15;63(2):139-45 [17585886] Behav Neural Biol. 1979 Dec;27(4):466-86 [575037] Psychopharmacology (Berl). 2001 Dec;158(4):374-81 [11797058] Trends Pharmacol Sci. 2002 Feb;23(2):71-7 [11830263] Pharmacol Biochem Behav. 2002 May;72(1-2):213-20 [11900791] J Pharmacol Exp Ther. 2002 Apr;301(1):322-32 [11907190] J Pharmacol Exp Ther. 2002 Apr;301(1):333-45 [11907191] Science. 2002 May 3;296(5569):931-3 [11988580] Pharmacol Biochem Behav. 2002 Aug;73(1):147-58 [12076734] Peptides. 2001 Mar;22(3):515-22 [11287109] Pharmacol Rev. 2001 Jun;53(2):209-43 [11356984] FASEB J. 2002 Jan;16(1):27-35 [11772933] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Future of molecular profiling of human hepatocellular carcinoma. AN - 68101934; 17661718 AB - Hepatocellular carcinoma (HCC) is a fatal disease occurring worldwide and developing mainly in chronic liver diseased patients. Despite routine screening of individuals at high risk, most of the patients are diagnosed at late stages of HCC. In addition, the recurrence rate after surgical resection of small tumors is high. Molecular profiling, including expression analysis, comparative genomics and proteomics, provides powerful tools to gain insight into the molecular mechanisms underlying carcinogenesis. Advances in bioinformatics have also allowed for the evaluation of large data sets. Therefore, molecular profiling of HCC using a Biological Expression Network Discovery (BLEND) strategy that integrates global molecular profiling data, including mRNA, miRNA, DNA methylation and DNA copy numbers from both the tumor and the surrounding microenvironment, along with mechanistic studies, may improve the diagnosis, treatment and prognosis of HCC patients. Such an approach will provide mechanistic insight into the pathogenesis of HCC, potentially leading to personalized medicine and the identification of new therapeutic targets. JF - Future oncology (London, England) AU - Roessler, Stephanie AU - Budhu, Anuradha AU - Wang, Xin Wei AD - National Cancer Institute, Laboratory of Human Carcinogenesis, Center for Cancer Research, NIH, 37 Convent Drive, Bldg. 37, Rm. 3044A, Bethesda, MD 20892-4258, USA. roesslst@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 429 EP - 439 VL - 3 IS - 4 SN - 1479-6694, 1479-6694 KW - Biomarkers, Tumor KW - 0 KW - Index Medicus KW - Liver Diseases -- complications KW - Humans KW - Prognosis KW - Gene Expression Profiling KW - Carcinoma, Hepatocellular -- etiology KW - Carcinoma, Hepatocellular -- diagnosis KW - Carcinoma, Hepatocellular -- genetics KW - Carcinoma, Hepatocellular -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68101934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Future+oncology+%28London%2C+England%29&rft.atitle=Future+of+molecular+profiling+of+human+hepatocellular+carcinoma.&rft.au=Roessler%2C+Stephanie%3BBudhu%2C+Anuradha%3BWang%2C+Xin+Wei&rft.aulast=Roessler&rft.aufirst=Stephanie&rft.date=2007-08-01&rft.volume=3&rft.issue=4&rft.spage=429&rft.isbn=&rft.btitle=&rft.title=Future+oncology+%28London%2C+England%29&rft.issn=14796694&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-25 N1 - Date created - 2007-07-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Recommended Newborn Screening Policy Change for the NICU Infant AN - 57237803; 200813214 AB - Newborn screening (NBS), the practice by which infants are tested for certain genetic and metabolic conditions by heel prick 3 to 5 days after birth, has been a beneficial and cost-effective public health strategy. Many of the screened conditions present in the first 2 weeks of life and are life threatening. Because of the risk of metabolic acidosis, seizures, coma, neurological devastation, or death, NBS is essential for prompt diagnosis and treatment, including dietary, hormonal, and other interventions. However, due to the fact that aminoglycosides, blood transfusions, nothing by mouth status, and the presence of heparinized solutions all potentially affect the screening results, NBS guidelines in neonatal intensive care units (NICUs) ought to be changed to obviate inaccurate results. These guidelines, originally initiated by nurses at the Johns Hopkins NICU due to the missed diagnosis and death of an infant, include screening the day of birth prior to any interventions, performing the screen at 1 and/or 2 weeks of life, and repeating screening as needed. [Copyright 2007 Sage Publications, Inc.] JF - Policy, Politics, & Nursing Practice AU - Balk, Katherine G AD - Johns Hopkins University, National Institutes of Health Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 210 EP - 219 PB - Sage Publications VL - 8 IS - 3 SN - 1527-1544, 1527-1544 KW - Screening KW - Intensive care units KW - Guidelines KW - Newborn babies KW - Health policy KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57237803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Policy%2C+Politics%2C+%26+Nursing+Practice&rft.atitle=Recommended+Newborn+Screening+Policy+Change+for+the+NICU+Infant&rft.au=Balk%2C+Katherine+G&rft.aulast=Balk&rft.aufirst=Katherine&rft.date=2007-08-01&rft.volume=8&rft.issue=3&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Policy%2C+Politics%2C+%26+Nursing+Practice&rft.issn=15271544&rft_id=info:doi/10.1177%2F1527154407309049 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-27 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Newborn babies; Screening; Health policy; Intensive care units; Guidelines DO - http://dx.doi.org/10.1177/1527154407309049 ER - TY - JOUR T1 - Frontal release signs and cognition in people with schizophrenia, their siblings and healthy controls AN - 57232064; 200804334 AB - Background Frontal release signs, a subset of neurological soft signs, are common in schizophrenia. Aims To explore the relationship between frontal release signs and neuropsychological tests of frontal lobe function in people with schizophrenia, their siblings and healthy controls. Method Neuropsychological tests and frontal release signs were measured in a cohort of index cases (n=302), their siblings (n=240) and healthy controls (n=346). Results The mean total score of frontal release signs was 1.5(s.d.=1.58)in the schizophrenia group, 0.54 (s.d. =0.92) for siblings and 0.42 (s.d. =0.77) for controls. Schizophrenia group scores were greater than healthy control or sibling cohort scores (P<0.0001), which did not differ. In all three cohorts, right grasp reflex scores positively correlated with number of perseverative errors on the Wisconsin Card Sort Task (P <0.05). In the schizophrenia group, frontal release signs scores showed an inverse correlation with IQ(R=-0.199, P<0.0005). Conclusions Our findings of relationships between frontal release signs and cognitive assays of cortical dysfunction and the increased frequency of these signs in people with schizophrenia implicate a cortical origin for these clinical signs and evidence of frontal lobe dysfunction in this disorder. Declaration of interest None. Adapted from the source document. JF - The British Journal of Psychiatry AU - Hyde, Thomas M AU - Goldberg, Terry E AU - Egan, Michael F AU - Lener, Marc C AU - Weinberger, Daniel R AD - Room 4N306, Building 10, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892.USA. Tel: + 1 301 496 8848, fax: +1 301 402 2751 Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 120 EP - 125 PB - Royal College of Psychiatrists, London UK VL - 191 SN - 0007-1250, 0007-1250 KW - Frontal lobes KW - Schizophrenia KW - Neuropsychological tests KW - Siblings KW - Cognition KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57232064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+Journal+of+Psychiatry&rft.atitle=Frontal+release+signs+and+cognition+in+people+with+schizophrenia%2C+their+siblings+and+healthy+controls&rft.au=Hyde%2C+Thomas+M%3BGoldberg%2C+Terry+E%3BEgan%2C+Michael+F%3BLener%2C+Marc+C%3BWeinberger%2C+Daniel+R&rft.aulast=Hyde&rft.aufirst=Thomas&rft.date=2007-08-01&rft.volume=191&rft.issue=&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=The+British+Journal+of+Psychiatry&rft.issn=00071250&rft_id=info:doi/10.1192%2Fbjp.bp.106.026773 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-03-04 N1 - Last updated - 2016-09-27 N1 - CODEN - BJPYAJ N1 - SubjectsTermNotLitGenreText - Schizophrenia; Frontal lobes; Siblings; Neuropsychological tests; Cognition DO - http://dx.doi.org/10.1192/bjp.bp.106.026773 ER - TY - JOUR T1 - Migraine headaches are not associated with a unique depressive symptom profile: Results from the Baltimore Epidemiologic Catchment Area Study AN - 57227601; 200807068 AB - Objective: There is a well-established link between migraine headaches and depression. However, it is unclear whether individuals with migraine experience a unique profile of depressive symptoms in comparison to individuals without migraine. Methods: This question was addressed using data from the Baltimore cohort of the Epidemiologic Catchment Area Study. The cross-sectional association between migraine headaches and each depressive symptom was calculated using logistic regression, and symptom profiles among those with migraine headaches (n=249) and those without (n=1480) were compared using generalized estimating equations. Results: Migraine headaches were associated with increased odds of reporting seven of nine depressive symptom groups by a factor of roughly 2. However, when the symptom profiles were compared, individuals with migraine headaches did not differ in their profile of symptoms. Conclusion: These results suggest that individuals with migraine headaches are more likely to report depressive symptoms but do not display a unique profile of symptoms. [Copyright 2007 Elsevier Inc.] JF - Journal of Psychosomatic Research AU - Kalaydjian, Amanda AU - Eaton, William AU - Zandi, Peter AD - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA kalaydjiana@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 123 EP - 129 PB - Elsevier Science Inc. VL - 63 IS - 2 SN - 0022-3999, 0022-3999 KW - Depression KW - Headache KW - Migraine KW - Symptoms KW - Suicide KW - Severity KW - Physical symptoms KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57227601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychosomatic+Research&rft.atitle=Migraine+headaches+are+not+associated+with+a+unique+depressive+symptom+profile%3A+Results+from+the+Baltimore+Epidemiologic+Catchment+Area+Study&rft.au=Kalaydjian%2C+Amanda%3BEaton%2C+William%3BZandi%2C+Peter&rft.aulast=Kalaydjian&rft.aufirst=Amanda&rft.date=2007-08-01&rft.volume=63&rft.issue=2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychosomatic+Research&rft.issn=00223999&rft_id=info:doi/10.1016%2Fj.jpsychores.2007.03.005 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-04-02 N1 - Last updated - 2016-09-27 N1 - CODEN - JPCRAT N1 - SubjectsTermNotLitGenreText - Depression; Suicide; Migraine; Physical symptoms DO - http://dx.doi.org/10.1016/j.jpsychores.2007.03.005 ER - TY - JOUR T1 - A proposed stereo matching algorithm for noisy sets of color images AN - 50520415; 2009-021288 AB - Modeling the world in three dimensions has been attracting a growing interest both in applications and science. In many cases, such 3D models are achieved by triangulating corresponding features recorded by several images of the same field taken from different points of view. This, however, requires the ability to match corresponding image elements detected in different images. In this paper, an algorithm for stereo matching in noisy pairs of outdoor images is described. The proposed algorithm applies a standard window-based correlation, but uses a fuzzy logic-based similarity function that models the HSV color space. This fuzzy logic modeling allows a robust color comparison that can tolerate a certain degree of changes in the illumination conditions and can be used for finding corresponding pixels in noisy sets of images. While the proposed algorithm does not introduce an improvement over existing methods in ideal conditions, experiments suggest that it provides significantly better results when the images in the set are relatively different from each other, and can be effective for matching corresponding features in images taken in different weather conditions, different positions of the sun, different optics or other real-life situations in which pinhole conditions are not available. JF - Computers & Geosciences AU - Shamir, Lior Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 1052 EP - 1063 PB - Elsevier, Amsterdam VL - 33 IS - 8 SN - 0098-3004, 0098-3004 KW - fuzzy logic KW - imagery KW - technology KW - three-dimensional models KW - stereographic projection KW - color KW - algorithms KW - remote sensing KW - 20:Applied geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50520415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computers+%26+Geosciences&rft.atitle=A+proposed+stereo+matching+algorithm+for+noisy+sets+of+color+images&rft.au=Shamir%2C+Lior&rft.aulast=Shamir&rft.aufirst=Lior&rft.date=2007-08-01&rft.volume=33&rft.issue=8&rft.spage=1052&rft.isbn=&rft.btitle=&rft.title=Computers+%26+Geosciences&rft.issn=00983004&rft_id=info:doi/10.1016%2Fj.cageo.2006.11.013 L2 - http://www.sciencedirect.com/science?_ob=JournalURL&_cdi=5840&_auth=y&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=e5198452fad934c6346f38b57511c8e0 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2009-01-01 N1 - Number of references - 40 N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - algorithms; color; fuzzy logic; imagery; remote sensing; stereographic projection; technology; three-dimensional models DO - http://dx.doi.org/10.1016/j.cageo.2006.11.013 ER - TY - JOUR T1 - Serotonergic influences on life-history outcomes in free-ranging male rhesus macaques AN - 36846510; 3526061 AB - Several studies have demonstrated that nonhuman primate males with low cerebrospinal fluid (CSF) levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) exhibit antisocial behavior patterns. Included in these deleterious patterns are impulse control deficits associated with violence and premature death. No studies to date have longitudinally studied the long-term outcome of young subjects with low CSF 5-HIAA concentrations as they mature into adults. In this study we examined longitudinal relations among serotonergic and dopaminergic functioning, as reflected in CSF metabolite concentrations, aggression, age at emigration, dominance rank, and mortality in free-ranging rhesus macaque (Macaca mulatta) males. Our results indicate long-term consistency of individual differences in levels of 5-HIAA in CSF in the subject population from the juvenile period of development through adulthood. We found a significant negative correlation between 5-HIAA concentrations measured in juveniles and rates of high-intensity aggression in the same animals as adults. Further, CSF 5-HIAA concentrations were lower in juveniles that died than in animals that survived. For the young animals that migrated there was a positive correlation between CSF 5-HIAA concentration and age at emigration, whereas for the animals that remained in their troop until later in sexual maturity there was a negative correlation between CSF 5-HIAA concentration and age of emigration. After animals emigrated to a new troop, social dominance rank in the new troop was positively correlated with early family social dominance rank, but inversely correlated with juvenile CSF 5-HIAA concentrations. Taken together, our findings suggest that males with low central serotonin levels early in life delay migration and show high levels of violence and premature death, but the males that survive achieve high rank. These findings indicate that longitudinal measures of serotonergic and dopaminergic functioning are predictive of major life-history outcomes in nonhuman primate males. Low concentrations of CSF 5-HIAA are associated with negative life-history patterns characterized by social instability and excessive aggression, and positive life-history patterns characterized by higher dominance rank. Copyright John Wiley & Sons. Reproduced with permission. An electronic version of this article is available online at http://www.interscience.wiley.com JF - American journal of primatology AU - Howell, Sue AU - Westergaard, Greg AU - Hoos, Beth AU - Chavanne, Tara J AU - Shoaf, Susan E AU - Cleveland, Allison AU - Snoy, Philip J AU - Suomi, Stephen J AU - Higley, J Dee AD - Division of Research and Development, Alpha Genesis, Inc., Yemassee ; Division of Research and Development, Alpha Genesis, Inc., Yemasee ; National Institute on Alcohol Abuse and Alcoholism ; Center for Biologics Evaluation and Research, Rockville ; National Institute of Child Health and Human Development Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 851 EP - 865 VL - 69 IS - 8 SN - 0275-2565, 0275-2565 KW - Anthropology KW - Macaques KW - Longitudinal studies KW - Mortality KW - Life history KW - Physical anthropology KW - Primatology KW - Primate behaviour KW - Migration KW - Hormones UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36846510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+primatology&rft.atitle=Serotonergic+influences+on+life-history+outcomes+in+free-ranging+male+rhesus+macaques&rft.au=Howell%2C+Sue%3BWestergaard%2C+Greg%3BHoos%2C+Beth%3BChavanne%2C+Tara+J%3BShoaf%2C+Susan+E%3BCleveland%2C+Allison%3BSnoy%2C+Philip+J%3BSuomi%2C+Stephen+J%3BHigley%2C+J+Dee&rft.aulast=Howell&rft.aufirst=Sue&rft.date=2007-08-01&rft.volume=69&rft.issue=8&rft.spage=851&rft.isbn=&rft.btitle=&rft.title=American+journal+of+primatology&rft.issn=02752565&rft_id=info:doi/10.1002%2Fajp.20369 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 9507 1077; 5983 9524 1615 8573 11325; 7541 7537 971; 8040; 7398 5889; 8291 3409 6306; 10144 10148 10149 1542 11325; 10149 DO - http://dx.doi.org/10.1002/ajp.20369 ER - TY - JOUR T1 - Methods for translating an English-language survey questionnaire on tobacco use into Mandarin, Cantonese, Korean, and Vietnamese AN - 36831315; 3519322 AB - This article reports research on procedures for translating a survey questionnaire on tobacco use from English into Mandarin Chinese, Cantonese Chinese, Korean, and Vietnamese. The goal is to offer practical guidelines for researchers involved in translating questionnaires. The authors operationalize a five-step process for translation and evaluation based on the frameworks presented in Harkness, Van de Vijver, and Mohler (2003) and the U.S. Census Bureau (2004). Based on qualitative observations, the five-step process produced effective questionnaire translations. The iterative nature of the process and the team-based approach the process encourages were particularly important to the success. Based on documented experiences, the authors identify lessons learned and make recommendations to other researchers who need to translate questionnaires. Reprinted by permission of Sage Publications Inc. JF - Field methods AU - Forsyth, Barbara H AU - Kudela, Martha Stapleton AU - Levin, Kerry AU - Lawrence, Deirdre AU - Willis, Gordon B AD - Westat, Rockville, Maryland ; National Cancer Institute Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 264 EP - 283 VL - 19 IS - 3 SN - 1525-822X, 1525-822X KW - Anthropology KW - Qualitative analysis KW - Evaluation KW - Translation KW - Questionnaires KW - Survey data KW - Tobacco KW - Anthropological research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36831315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Field+methods&rft.atitle=Methods+for+translating+an+English-language+survey+questionnaire+on+tobacco+use+into+Mandarin%2C+Cantonese%2C+Korean%2C+and+Vietnamese&rft.au=Forsyth%2C+Barbara+H%3BKudela%2C+Martha+Stapleton%3BLevin%2C+Kerry%3BLawrence%2C+Deirdre%3BWillis%2C+Gordon+B&rft.aulast=Forsyth&rft.aufirst=Barbara&rft.date=2007-08-01&rft.volume=19&rft.issue=3&rft.spage=264&rft.isbn=&rft.btitle=&rft.title=Field+methods&rft.issn=1525822X&rft_id=info:doi/10.1177%2F1525822X07302105 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1069 10902; 12427 12429; 10541; 12927 7239 7226; 12766 3055 798 10286; 4551; 10519 3279 971 3286 DO - http://dx.doi.org/10.1177/1525822X07302105 ER - TY - JOUR T1 - Prolonged survival in poor-risk diffuse large B-cell lymphoma following front-line treatment with rituximab-supplemented, early-intensified chemotherapy with multiple autologous hematopoietic stem cell support: a multicenter study by GITIL (Gruppo Italiano Terapie Innovative nei Linfomi) AN - 220536854; 17554382 AB - A prospective multicenter program was performed to evaluate the combination of rituximab and high-dose (hd) sequential chemotherapy delivered with multiple autologous peripheral blood progenitor cell (PBPC) support (R-HDS-maps regimen) in previously untreated patients with diffuse large B-cell lymphoma (DLB-CL) and age-adjusted International Prognostic Score (aaIPI) score 2-3. R-HDS-maps includes: (i) three APO courses; (ii) sequential administration of hd-cyclophosphamide (CY), hd-Ara-C, both supplemented with rituximab, hd-etoposide/cisplatin, PBPC harvests, following hd-CY and hd-Ara-C; (iii) hd-mitoxantrone (hd-Mito)/L-Pam + 2 further rituximab doses; (iv) involved-field radiotherapy. PBPC rescue was scheduled following Ara-C, etoposide/cisplatin and Mito/L-Pam. Between 1999 and 2004, 112 consecutive patients aged <65 years (74 score 2, 38 score 3) entered the study protocol. There were five early and two late toxic deaths. Overall 90 patients (80%) reached clinical remission (CR); at a median 48 months follow-up, 87 (78%) patients are alive, 82 (73%) in continuous CR, with 4 year overall survival (OS) and event-free survival (EFS) projections of 76% (CI 68-85%) and 73% (CI 64-81%), respectively. There were no significant differences in OS and EFS between subgroups with Germinal-Center and Activated B-cell phenotype. Thus, life expectancy of younger patients with aaIPI 2-3 DLB-CL is improved with the early administration of rituximab-supplemented intensive chemotherapy compared with the poor outcome following conventional chemotherapy. JF - Leukemia AU - Tarella, C AU - Zanni, M AU - M Di Nicola AU - Patti, C AU - Calvi, R AU - Pescarollo, A AU - Zoli, V AU - Fornari, A AU - Novero, D AU - Cabras, A AU - Stella, M AU - Comino, A AU - Remotti, D AU - Ponzoni, M AU - Caracciolo, D AU - Ladetto, M AU - Magni, M AU - Devizzi, L AU - Rosato, R AU - Boccadoro, M AU - Bregni, M AU - Corradini, P AU - Gallamini, A Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 1802 EP - 11 CY - London PB - Nature Publishing Group VL - 21 IS - 8 SN - 08876924 KW - Medical Sciences--Oncology KW - Antibodies, Monoclonal KW - Antibodies, Monoclonal, Murine-Derived KW - rituximab KW - Cytarabine KW - Etoposide KW - Cyclophosphamide KW - Mitoxantrone KW - Cisplatin KW - Melphalan KW - Cyclophosphamide -- administration & dosage KW - Disease-Free Survival KW - Combined Modality Therapy KW - Humans KW - Mitoxantrone -- administration & dosage KW - Cytarabine -- administration & dosage KW - Transplantation, Autologous KW - Antibodies, Monoclonal -- administration & dosage KW - Cisplatin -- administration & dosage KW - Feasibility Studies KW - Prospective Studies KW - Etoposide -- administration & dosage KW - Melphalan -- administration & dosage KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Peripheral Blood Stem Cell Transplantation KW - Lymphoma, B-Cell -- therapy KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Lymphoma, Large B-Cell, Diffuse -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/220536854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia&rft.atitle=Prolonged+survival+in+poor-risk+diffuse+large+B-cell+lymphoma+following+front-line+treatment+with+rituximab-supplemented%2C+early-intensified+chemotherapy+with+multiple+autologous+hematopoietic+stem+cell+support%3A+a+multicenter+study+by+GITIL+%28Gruppo+Italiano+Terapie+Innovative+nei+Linfomi%29&rft.au=Tarella%2C+C%3BZanni%2C+M%3BM+Di+Nicola%3BPatti%2C+C%3BCalvi%2C+R%3BPescarollo%2C+A%3BZoli%2C+V%3BFornari%2C+A%3BNovero%2C+D%3BCabras%2C+A%3BStella%2C+M%3BComino%2C+A%3BRemotti%2C+D%3BPonzoni%2C+M%3BCaracciolo%2C+D%3BLadetto%2C+M%3BMagni%2C+M%3BDevizzi%2C+L%3BRosato%2C+R%3BBoccadoro%2C+M%3BBregni%2C+M%3BCorradini%2C+P%3BGallamini%2C+A&rft.aulast=Tarella&rft.aufirst=C&rft.date=2007-08-01&rft.volume=21&rft.issue=8&rft.spage=1802&rft.isbn=&rft.btitle=&rft.title=Leukemia&rft.issn=08876924&rft_id=info:doi/10.1038%2Fsj.leu.2404781 LA - English DB - ProQuest Central N1 - Copyright - Copyright Nature Publishing Group Aug 2007 N1 - Last updated - 2014-03-30 DO - http://dx.doi.org/10.1038/sj.leu.2404781 ER - TY - JOUR T1 - The Bipolar Disorder Phenome Database: A Resource for Genetic Studies AN - 220471780; 17671286 AB - The purpose of this study was to assemble and validate a database of phenotypic variables that were collected from families with bipolar disorder as a resource for genetic and other biological studies. Participants were ascertained for two bipolar disorder genetic linkage studies: the University of Chicago, Johns Hopkins, and National Institute of Mental Health (NIMH) Intramural Program (CHIP) Collaboration and the NIMH Genetics Initiative project. All participants underwent detailed, phenotypic assessment with either the Schedule for Affective Disorders and Schizophrenia-Lifetime Version or one of four versions of the Diagnostic Interview for Genetic Studies. Clinicians reviewed the interview items and derived variable definitions that were used to extract data from the original datasets. The combined data were subjected to range and logic assessments, and a subset was re-verified against the original data Inconsistent data and variables that were deemed unreliable were excluded. Several of the resulting variables were characterized in the total cohort and tested for familial clustering, heritability, and statistical power in genetic linkage and association studies. The combined database of phenotypic variables contained 197 variables on 5,721 subjects in 1,177 families. Deoxyribonucleic acid (DNA) samples are available for 5,373 of these subjects. The clinical presentation of bipolar disorder varied markedly. Most subjects suffered from serious and often disabling illness. Many phenotypic variables are strongly familial, and some quantitative variables are highly heritable. The cohort assembled in this study offers substantial power to carry out genetic linkage and association studies that use specific clinical features as covariates or as primary phenotypes. This is the largest database of phenotypic variables yet assembled for bipolar disorder, and it is now available to the research community. Researchers and clinicians can use this database to explore the connections between phenomenology and genetics in a cohort that is adequately powered to detect even modest genetic effects in bipolar disorder. JF - The American Journal of Psychiatry AU - Potash, James B AU - Toolan, Jennifer AU - Steele, Jo AU - Miller, Erin B AU - et al Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 1229 EP - 37 CY - Washington PB - American Psychiatric Association VL - 164 IS - 8 SN - 0002953X KW - Medical Sciences--Psychiatry And Neurology KW - Schizophrenia KW - Studies KW - Alzheimers disease KW - Bipolar disorder KW - Genes KW - United States KW - Pedigree KW - Genetic Linkage KW - Genetic Variation KW - Reproducibility of Results KW - Humans KW - National Institute of Mental Health (U.S.) KW - Research Design KW - Chromosome Mapping KW - Comorbidity KW - Phenotype KW - Genotype KW - Genetic Testing KW - Genetic Predisposition to Disease -- genetics KW - Psychotic Disorders -- genetics KW - Adult KW - Cohort Studies KW - Female KW - Male KW - Genetic Research KW - Databases, Genetic -- statistics & numerical data KW - Bipolar Disorder -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/220471780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=The+Bipolar+Disorder+Phenome+Database%3A+A+Resource+for+Genetic+Studies&rft.au=Potash%2C+James+B%3BToolan%2C+Jennifer%3BSteele%2C+Jo%3BMiller%2C+Erin+B%3Bet+al&rft.aulast=Potash&rft.aufirst=James&rft.date=2007-08-01&rft.volume=164&rft.issue=8&rft.spage=1229&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Psychiatric Association Aug 2007 N1 - Document feature - Diagrams; Tables; References N1 - Last updated - 2013-02-10 N1 - CODEN - AJPSAO ER - TY - JOUR T1 - Computed Tomography Screening for Lung Cancer AN - 21244645; 7557205 JF - JAMA: Journal of the American Medical Association AU - Berg, Christine D AU - Aberle, Denise R AD - National Cancer Institute , Bethesda, Maryland , David Geffen School of Medicine at UCLA , Los Angeles, California, bergc@mail.nih.gov Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 513 EP - 514 PB - American Medical Association, 515 N. State St. Chicago IL 60610 USA VL - 298 IS - 5 SN - 0098-7484, 0098-7484 KW - Biotechnology and Bioengineering Abstracts KW - Computed tomography KW - Lung cancer KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21244645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA%3A+Journal+of+the+American+Medical+Association&rft.atitle=Computed+Tomography+Screening+for+Lung+Cancer&rft.au=Berg%2C+Christine+D%3BAberle%2C+Denise+R&rft.aulast=Berg&rft.aufirst=Christine&rft.date=2007-08-01&rft.volume=298&rft.issue=5&rft.spage=513&rft.isbn=&rft.btitle=&rft.title=JAMA%3A+Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Computed tomography; Lung cancer ER - TY - JOUR T1 - Tonsil Epithelial Factors May Influence Oropharyngeal Human Immunodeficiency Virus Transmission AN - 21209314; 11653116 AB - Tonsil epithelium has been implicated in human immunodeficiency virus (HIV) pathogenesis, but its role in oral transmission remains controversial. To study characteristics of this tissue, which may influence susceptibility or resistance to HIV, we performed microarray analysis of the tonsil epithelium. Our data revealed that genes related to immune functions such as antibody production and antigen processing were increasingly expressed in tonsil compared with the epithelium of another oropharyngeal site, the gingival epithelium. Importantly, tonsil epithelium highly expressed genes associated with HIV entrapment and/or transmission, including the HIV co-receptor CXCR4 and the potential HIV-binding molecules FcRgIII, complement receptor 2, and various complement components. Immunohistochemical staining confirmed the increased presence of CXCR4 in the tonsil epithelium compared with multiple oral epithelial sites, particularly in basal and parabasal layers. This increased expression of molecules involved in viral recognition, binding, and entry may favor virus-epithelium interactions in an environment with reduced innate antiviral mechanisms. Specifically, secretory leukocyte protease inhibitor, an innate molecule with anti-HIV activity, was minimal in the tonsil epithelium, in contrast to oral mucosa. Collectively, our data suggest that increased expression of molecules associated with HIV binding and entry coupled with decreased innate antiviral factors may render the tonsil a potential site for oral transmission. JF - American Journal of Pathology AU - Moutsopoulos, N M AU - Nares, S AU - Nikitakis, N AU - Rangel, Z AU - Wen, J AU - Munson, P AU - Sauk, J AU - Wahl, S M AD - Oral Infection and Immunity Branch, Center for Information Technology, National Institutes of Health, Bethesda, USA Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 571 EP - 579 VL - 171 IS - 2 SN - 0002-9440, 0002-9440 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Data processing KW - CXCR4 protein KW - Leukocytes KW - Gingiva KW - Proteinase inhibitors KW - Mucosa KW - Antiviral activity KW - Disease transmission KW - Antibodies KW - Tonsil KW - Human immunodeficiency virus KW - complement receptor 2 KW - Antigen processing KW - Epithelium KW - Immune response KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21209314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Pathology&rft.atitle=Tonsil+Epithelial+Factors+May+Influence+Oropharyngeal+Human+Immunodeficiency+Virus+Transmission&rft.au=Moutsopoulos%2C+N+M%3BNares%2C+S%3BNikitakis%2C+N%3BRangel%2C+Z%3BWen%2C+J%3BMunson%2C+P%3BSauk%2C+J%3BWahl%2C+S+M&rft.aulast=Moutsopoulos&rft.aufirst=N&rft.date=2007-08-01&rft.volume=171&rft.issue=2&rft.spage=571&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Pathology&rft.issn=00029440&rft_id=info:doi/10.2353%2Fajpath.2007.061006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Data processing; CXCR4 protein; Mucosa; Proteinase inhibitors; Gingiva; Leukocytes; Antiviral activity; Disease transmission; Antibodies; Tonsil; complement receptor 2; Epithelium; Antigen processing; Immune response; Human immunodeficiency virus DO - http://dx.doi.org/10.2353/ajpath.2007.061006 ER - TY - JOUR T1 - NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of hydroxyurea AN - 21056489; 7596918 AB - Abstract not available. JF - Birth Defects Research Part B: Developmental and Reproductive Toxicology AU - Liebelt, Erica L AU - Balk, Sophie J AU - Faber, Willem AU - Fisher, Jeffrey W AU - Hughes, Claude L AU - Lanzkron, Sophie M AU - Lewis, Kerry M AU - Marchetti, Francesco AU - Mehendale, Harihara M AU - Rogers, John M AU - Shad, Aziza T AU - Skalko, Richard G AU - Stanek, Edward J AD - University of Alabama, Birmingham, AL, Shelby@niehs.nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 259 EP - 366 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 80 IS - 4 SN - 1542-9733, 1542-9733 KW - Toxicology Abstracts KW - Hydroxyurea KW - Congenital defects KW - Toxicity KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21056489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.atitle=NTP-CERHR+Expert+Panel+Report+on+the+reproductive+and+developmental+toxicity+of+hydroxyurea&rft.au=Liebelt%2C+Erica+L%3BBalk%2C+Sophie+J%3BFaber%2C+Willem%3BFisher%2C+Jeffrey+W%3BHughes%2C+Claude+L%3BLanzkron%2C+Sophie+M%3BLewis%2C+Kerry+M%3BMarchetti%2C+Francesco%3BMehendale%2C+Harihara+M%3BRogers%2C+John+M%3BShad%2C+Aziza+T%3BSkalko%2C+Richard+G%3BStanek%2C+Edward+J&rft.aulast=Liebelt&rft.aufirst=Erica&rft.date=2007-08-01&rft.volume=80&rft.issue=4&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.issn=15429733&rft_id=info:doi/10.1002%2Fbdrc.20068 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Hydroxyurea; Congenital defects; Toxicity DO - http://dx.doi.org/10.1002/bdrc.20068 ER - TY - JOUR T1 - Purine Salvage Pathways among Borrelia Species AN - 21006252; 7530478 AB - Genome sequencing projects on two relapsing fever spirochetes, Borrelia hermsii and Borrelia turicatae, revealed differences in genes involved in purine metabolism and salvage compared to those in the Lyme disease spirochete Borrelia burgdorferi. The relapsing fever spirochetes contained six open reading frames that are absent from the B. burgdorferi genome. These genes included those for hypoxanthine-guanine phosphoribosyltransferase (hpt), adenylosuccinate synthase (purA), adenylosuccinate lyase (purB), auxiliary protein (nrdI), the ribonucleotide-diphosphate reductase alpha subunit (nrdE), and the ribonucleotide-diphosphate reductase beta subunit (nrdF). Southern blot assays with multiple Borrelia species and isolates confirmed the presence of these genes in the relapsing fever group of spirochetes but not in B. burgdorferi and related species. TaqMan real-time reverse transcription-PCR demonstrated that the chromosomal genes (hpt, purA, and purB) were transcribed in vitro and in mice. Phosphoribosyltransferase assays revealed that, in general, B. hermsii exhibited significantly higher activity than did the B. burgdorferi cell lysate, and enzymatic activity was observed with adenine, hypoxanthine, and guanine as substrates. B. burgdorferi showed low but detectable phosphoribosyltransferase activity with hypoxanthine even though the genome lacks a discernible ortholog to the hpt gene in the relapsing fever spirochetes. B. hermsii incorporated radiolabeled hypoxanthine into RNA and DNA to a much greater extent than did B. burgdorferi. This complete pathway for purine salvage in the relapsing fever spirochetes may contribute, in part, to these spirochetes achieving high cell densities in blood. JF - Infection and Immunity AU - Pettersson, Jonas AU - Schrumpf, Merry E AU - Raffel, Sandra J AU - Porcella, Stephen F AU - Guyard, Cyril AU - Lawrence, Kevin AU - Gherardini, Frank C AU - Schwan, Tom G AD - Laboratory of Zoonotic Pathogens. Research Technologies Section, Research Technologies Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840 Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 3877 EP - 3884 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 8 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Genomes KW - Borrelia hermsii KW - HPT gene KW - Relapsing fever KW - Cell density KW - phosphoribosyltransferase KW - Guanine KW - reductase KW - Adenine KW - Enzymatic activity KW - Lyme disease KW - Adenylosuccinate lyase KW - Borrelia burgdorferi KW - Lymphocytes B KW - Borrelia turicatae KW - purines KW - Spirochetes KW - Blood KW - RNA KW - Adenylosuccinate synthase KW - Hypoxanthine KW - DNA KW - Open reading frames KW - Metabolism KW - J 02320:Cell Biology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21006252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Purine+Salvage+Pathways+among+Borrelia+Species&rft.au=Pettersson%2C+Jonas%3BSchrumpf%2C+Merry+E%3BRaffel%2C+Sandra+J%3BPorcella%2C+Stephen+F%3BGuyard%2C+Cyril%3BLawrence%2C+Kevin%3BGherardini%2C+Frank+C%3BSchwan%2C+Tom+G&rft.aulast=Pettersson&rft.aufirst=Jonas&rft.date=2007-08-01&rft.volume=75&rft.issue=8&rft.spage=3877&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; Adenylosuccinate lyase; HPT gene; Lymphocytes B; Relapsing fever; phosphoribosyltransferase; Cell density; purines; Blood; Spirochetes; Guanine; reductase; RNA; Adenylosuccinate synthase; DNA; Hypoxanthine; Adenine; Enzymatic activity; Metabolism; Open reading frames; Lyme disease; Borrelia hermsii; Borrelia burgdorferi; Borrelia turicatae ER - TY - JOUR T1 - CYP3A4 and pregnane X receptor humanized mice AN - 21004407; 8499574 AB - Marked species differences exist in P450 expression and activities. In order to produce mouse models that can be used to more accurately predict human drug and carcinogen metabolism, P450- and xenobiotic receptor humanized mice are being prepared using bacterial artificial chromosomes (BAC) and P1 phage artificial chromosomes (PAC) genomic clones. In some cases, transgenic mice carrying the human genes are bred with null-mice to produce fully humanized mice. Mice expressing human CYP1A1, CYP1A2, CYP2E1, CYP2D6, CYP3A4, and CYP3A7 were generated and characterized. Studies with the CYP3A4-humanized (hCYP3A4) mouse line revealed new information on the physiological function of this P450 and its role in drug metabolism in vivo. With this mouse line, CYP3A4, under certain circumstances, was found to alter the serum levels of estrogen resulting in deficient lactation and low pup survival as a result of underdeveloped mammary glands. This hCYP3A4 mouse established the importance of intestinal CYP3A4 in the pharmacokinetics of orally administered drugs. The hCYP3A4 mice were also used to establish the mechanisms of potential gender differences in CYP3A4 expression (adult female > adult male) that could account for human gender differences in drug metabolism and response. The pregnane X receptor (PXR) is also involved in induction of drug metabolism through its target genes including CYP3A4. Since species differences exist in ligand specificity between human and mice, a PXR-humanized mouse (hPXR) was produced that responds to human PXR activators such as rifampicin but does not respond to the rodent activator pregnenalone 16-carbonitrile. JF - Journal of Biochemical and Molecular Toxicology AU - Gonzalez, Frank J AD - Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA, fjgonz@helix.nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 158 EP - 162 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 21 IS - 4 SN - 1095-6670, 1095-6670 KW - Microbiology Abstracts B: Bacteriology KW - Phages KW - Animal models KW - Survival KW - Carcinogens KW - Sex differences KW - Rifampin KW - Chromosomes KW - genomics KW - Drugs KW - Estrogens KW - CYP1A2 protein KW - CYP3A7 protein KW - Mammary gland KW - Drug metabolism KW - Oral administration KW - Transgenic mice KW - Pharmacokinetics KW - Lactation KW - Bacterial artificial chromosomes KW - Serum levels KW - Intestine KW - pregnane X receptors KW - Cytochrome P450 KW - CYP2D6 protein KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21004407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biochemical+and+Molecular+Toxicology&rft.atitle=CYP3A4+and+pregnane+X+receptor+humanized+mice&rft.au=Gonzalez%2C+Frank+J&rft.aulast=Gonzalez&rft.aufirst=Frank&rft.date=2007-08-01&rft.volume=21&rft.issue=4&rft.spage=158&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biochemical+and+Molecular+Toxicology&rft.issn=10956670&rft_id=info:doi/10.1002%2Fjbt.20173 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Phages; Estrogens; CYP1A2 protein; CYP3A7 protein; Mammary gland; Drug metabolism; Oral administration; Animal models; Survival; Carcinogens; Transgenic mice; Sex differences; Pharmacokinetics; Lactation; Serum levels; Bacterial artificial chromosomes; Rifampin; Chromosomes; Intestine; genomics; Cytochrome P450; pregnane X receptors; Drugs; CYP2D6 protein DO - http://dx.doi.org/10.1002/jbt.20173 ER - TY - JOUR T1 - Amended Description of the Genes for Synthesis of Actinomyces naeslundii T14V Type 1 Fimbriae and Associated Adhesin AN - 21000889; 7530510 AB - The type 1 fimbriae of Actinomyces naeslundii T14V mediate adhesion of this gram-positive species to the tooth surface. The present findings show that the locus for type 1 fimbria production in this strain includes three genes, fimQ for a minor fimbrial subunit that appears to be an adhesin, fimP for the major structural subunit, and srtC1 for a type 1 fimbria-specific sortase involved in the assembly of these structures. JF - Infection and Immunity AU - Chen, Ping AU - Cisar, John O AU - Hess, Sonja AU - Ho, Jenny TC AU - Leung, Kai P AD - Microbiology Branch, U.S. Army Dental and Trauma Research Detachment, Walter Reed Army Institute of Research, Great Lakes, Illinois 60088. Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research. Proteomics and Mass Spectrometry Facility, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 4181 EP - 4185 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 8 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Teeth KW - Adhesins KW - Pili KW - sortase KW - Actinomyces naeslundii KW - Fimbria KW - J 02310:Genetics & Taxonomy KW - F 06910:Microorganisms & Parasites KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21000889?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Amended+Description+of+the+Genes+for+Synthesis+of+Actinomyces+naeslundii+T14V+Type+1+Fimbriae+and+Associated+Adhesin&rft.au=Chen%2C+Ping%3BCisar%2C+John+O%3BHess%2C+Sonja%3BHo%2C+Jenny+TC%3BLeung%2C+Kai+P&rft.aulast=Chen&rft.aufirst=Ping&rft.date=2007-08-01&rft.volume=75&rft.issue=8&rft.spage=4181&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Teeth; Adhesins; Pili; sortase; Actinomyces naeslundii; Fimbria ER - TY - JOUR T1 - Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8 super(+) T cells via TLR4 signaling AN - 20953660; 11055115 AB - Lymphodepletion with total body irradiation (TBI) increases the efficacy of adoptively transferred tumor-specific CD8 super(+) T cells by depleting inhibitory lymphocytes and increasing homeostatic cytokine levels. We found that TBI augmented the function of adoptively transferred CD8 super(+) T cells in mice genetically deficient in all lymphocytes, indicating the existence of another TBI mechanism of action. Additional investigation revealed commensal gut microflora in the mesenteric lymph nodes and elevated LPS levels in the sera of irradiated mice. These findings correlated with increased dendritic cell activation and heightened levels of systemic inflammatory cytokines. Reduction of host microflora using antibiotics, neutralization of serum LPS using polymyxin B, or removal of LPS signaling components using mice genetically deficient in CD14 and TLR4 reduced the beneficial effects of TBI on tumor regression. Conversely, administration of microbial ligand-containing serum or ultrapure LPS from irradiated animals to nonirradiated antibody-lymphodepleted mice enhanced CD8 super(+) T cell activation and improved tumor regression. Administration of ultrapure LPS to irradiated animals further enhanced the number and function of the adoptively transferred cells, leading to long-term cure of mice with large B16F10 tumors and enhanced autoimmune vitiligo. Thus, disruption of the homeostatic balance between the host and microbes can enhance cell-based tumor immunotherapy. JF - Journal of Clinical Investigation AU - Paulos, G M AU - Wrzesinski, C AU - Kaiser, A AU - Hinrichs, C S AU - Chieppa, M AU - Cassard, L AU - Palmer, D C AU - Boni, A AU - Muranski, P AU - Yu, Z AU - Gattinoni, L AU - Antony, P A AU - Rosenberg, SA AU - Restifo, N P AD - National Cancer Institute (NCI), NIH, Bethesda, Maryland, USA Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 2197 EP - 2204 VL - 117 IS - 8 SN - 0021-9738, 0021-9738 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Immunotherapy KW - Commensals KW - Antibiotics KW - polymyxin B KW - CD8 antigen KW - Tumors KW - CD14 antigen KW - Vitiligo KW - Lymph nodes KW - Cell activation KW - Inflammation KW - Dendritic cells KW - Digestive tract KW - Radiation KW - Microflora KW - Lymphocytes T KW - Cytokines KW - Lipopolysaccharides KW - TLR4 protein KW - Translocation KW - Toll-like receptors KW - Signal transduction KW - A 01340:Antibiotics & Antimicrobials KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20953660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Investigation&rft.atitle=Microbial+translocation+augments+the+function+of+adoptively+transferred+self%2Ftumor-specific+CD8+super%28%2B%29+T+cells+via+TLR4+signaling&rft.au=Paulos%2C+G+M%3BWrzesinski%2C+C%3BKaiser%2C+A%3BHinrichs%2C+C+S%3BChieppa%2C+M%3BCassard%2C+L%3BPalmer%2C+D+C%3BBoni%2C+A%3BMuranski%2C+P%3BYu%2C+Z%3BGattinoni%2C+L%3BAntony%2C+P+A%3BRosenberg%2C+SA%3BRestifo%2C+N+P&rft.aulast=Paulos&rft.aufirst=G&rft.date=2007-08-01&rft.volume=117&rft.issue=8&rft.spage=2197&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Investigation&rft.issn=00219738&rft_id=info:doi/10.1172%2FJCI32205 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Immunotherapy; Commensals; Antibiotics; Tumors; CD8 antigen; polymyxin B; CD14 antigen; Vitiligo; Lymph nodes; Inflammation; Cell activation; Dendritic cells; Digestive tract; Radiation; Lymphocytes T; Microflora; Lipopolysaccharides; Cytokines; Translocation; TLR4 protein; Toll-like receptors; Signal transduction DO - http://dx.doi.org/10.1172/JCI32205 ER - TY - JOUR T1 - Three-dimensional analytical magnetic resonance imaging phantom in the Fourier domain AN - 20858045; 8368550 AB - This work presents a basic framework for constructing a 3D analytical MRI phantom in the Fourier domain. In the image domain the phantom is modeled after the work of Kak and Roberts on a 3D version of the famous Shepp-Logan head phantom. This phantom consists of several ellipsoids of different sizes, orientations, locations, and signal intensities (or gray levels). It will be shown that the k-space signal derived from the phantom can be analytically expressed. As a consequence, it enables one to bypass the need for interpolation in the Fourier domain when testing image-reconstruction algorithms. More importantly, the proposed framework can serve as a benchmark for contrasting and comparing different image-reconstruction techniques in 3D MRI with a non-Cartesian k-space trajectory. The proposed framework can also be adapted for 3D MRI simulation studies in which the MRI parameters of interest may be introduced to the signal intensity from the ellipsoid. JF - Magnetic Resonance in Medicine AU - Koay, Cheng Guan AU - Sarlls, Joelle E AU - Ozarslan, Evren AD - National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA, guankoac@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 430 EP - 436 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 58 IS - 2 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Head KW - Magnetic resonance imaging KW - Algorithms KW - N.M.R. KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20858045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Three-dimensional+analytical+magnetic+resonance+imaging+phantom+in+the+Fourier+domain&rft.au=Koay%2C+Cheng+Guan%3BSarlls%2C+Joelle+E%3BOzarslan%2C+Evren&rft.aulast=Koay&rft.aufirst=Cheng&rft.date=2007-08-01&rft.volume=58&rft.issue=2&rft.spage=430&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21292 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; Algorithms; Head; N.M.R. DO - http://dx.doi.org/10.1002/mrm.21292 ER - TY - JOUR T1 - Single-walled tubulin ring polymers AN - 20798845; 7586148 AB - An unusual class of nanoscopic, ring-shaped, single-walled biopolymers arises when -tubulin is mixed with certain small peptides obtained from various marine organisms and cyanobacteria. The single-ring structures, whose mean molecular weight depends on the specific peptide added to the reaction mixture, usually have sharp mass distributions corresponding, e.g., to rings containing eight tubulin dimers (when the added peptide is cryptophycin) and 14 dimers (e.g., with dolastatin). Although the ring-forming peptides have been shown to possess antimitotic properties when tested with cultured eukaryotic cells (and thus have generated considerable interest as possible agents to be used in the treatment of cancer), it is not our intention to extensively discuss the potential pharmacological properties of the peptides. Rather, we will review the polymeric structures that form and illustrate how certain physical techniques can be used to characterize their properties and interactions. The nanoscopic size and particular geometry of the individual rings make them appropriate targets for scattering and hydrodynamic techniques that provide details about their structure in solution, but it is necessary to relate measured data to postulated structures by nontrivial, albeit straight-forward, mathematical, and computational means. We will discuss how this is done when one uses such methods as small angle neutron scattering, dynamic light scattering, fluorescence correlation spectroscopy, and sedimentation velocity measurements. Moreover, we show that, by using several techniques, one can eliminate degeneracy to provide better discrimination between model structures. JF - Biopolymers AU - Boukari, Hacene AU - Sackett, Dan L AU - Schuck, Peter AU - Nossal, Ralph J AD - Laboratory of Integrative and Medical Biophysics, NICHD, National Institutes of Health, Bethesda, MD 20892, boukarih@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 424 EP - 436 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 86 IS - 5-6 SN - 0006-3525, 0006-3525 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - Mathematical models KW - Hydrodynamics KW - Motivation KW - Light scattering KW - Biopolymers KW - Computer applications KW - Cancer KW - fluorescence spectroscopy KW - Neutron scattering KW - Reviews KW - Molecular weight KW - Marine organisms KW - Sedimentation KW - Tubulin KW - K 03330:Biochemistry KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20798845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biopolymers&rft.atitle=Single-walled+tubulin+ring+polymers&rft.au=Boukari%2C+Hacene%3BSackett%2C+Dan+L%3BSchuck%2C+Peter%3BNossal%2C+Ralph+J&rft.aulast=Boukari&rft.aufirst=Hacene&rft.date=2007-08-01&rft.volume=86&rft.issue=5-6&rft.spage=424&rft.isbn=&rft.btitle=&rft.title=Biopolymers&rft.issn=00063525&rft_id=info:doi/10.1002%2Fbip.20752 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Mathematical models; Motivation; Hydrodynamics; Biopolymers; Light scattering; Computer applications; Cancer; fluorescence spectroscopy; Neutron scattering; Molecular weight; Reviews; Marine organisms; Tubulin; Sedimentation DO - http://dx.doi.org/10.1002/bip.20752 ER - TY - JOUR T1 - A prospective study of polymorphisms of DNA repair genes XRCC1, XPD23 and APE/ref-1 and risk of stroke in Linxian, China AN - 20756886; 7531528 AB - BACKGROUND: Stroke is the leading cause of death in Linxian, China. Although there is evidence of DNA damage in experimental stroke, no data exist on DNA repair and stroke in human populations. Aim: To assess the risk of stroke conferred by polymorphisms in the DNA repair genes, XRCC1, XPD23 and APE/ref-1 in a cohort of individuals originally assembled as subjects in two cancer prevention trials in Linxian, China. METHODS: The subjects for this prospective study were sampled from a cohort of 4005 eligible subjects who were alive and cancer free in 1991 and had blood samples available for DNA extraction. Using real-time Taqman analyses, all incident cases of stroke (n = 118) that developed from May 1996, and an age- and a sex-stratified random sample (n = 454) drawn from all eligible subjects were genotyped. Cox proportional hazards models were used to estimate relative risks (RRs) and 95% CIs. RESULTS: No association was observed between polymorphisms in APE/ref-1 codon 148 and XRCC1*6 codon 194, and stroke. Polymorphisms in XRCC1*10 codon 399 were associated with a significantly reduced risk of stroke (RR 0.59, 95% CI 0.36 to 0.96, p = 0.033), whereas XPD23 codon 312 was associated with a significantly increased risk of stroke (RR 2.18, 95% CI 1.14 to 4.17, p = 0.010). CONCLUSIONS: Polymorphisms in DNA repair genes may be important in the aetiology of stroke. These data should stimulate research on DNA damage and repair in stroke. JF - Journal of Epidemiology and Community Health AU - Mahabir, Somdat AU - Abnet, Christian C AU - Qiao, You-Lin AU - Ratnasinghe, Luke D AU - Dawsey, Sanford M AU - Dong, Zhi-Wei AU - Taylor, Philip R AU - Mark, Steven D AD - Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. Department of Epidemiology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing, People's Republic of China. Center for Structural Genomics, NCTR, Food and Drug Administration, Jefferson and Arkansas Cancer Research Center, UAMS, Little Rock, Arkansas, USA. Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 737 EP - 741 PB - British Medical Association, BMA House Square Tavistock Square London WC1H 9JP UK, [mailto:info.web@bma.org.uk], [URL:http://www.bma.org.uk/] VL - 61 IS - 8 SN - 0143-005X, 0143-005X KW - stroke KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Risk Abstracts KW - Risk assessment KW - Mortality KW - Gene polymorphism KW - Stroke KW - X chromosome KW - XRCC1 protein KW - DNA repair KW - Cancer KW - Models KW - risk reduction KW - DNA damage KW - DNA KW - prevention KW - Codons KW - China, People's Rep. KW - human populations KW - G 07880:Human Genetics KW - N 14820:DNA Metabolism & Structure KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20756886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Epidemiology+and+Community+Health&rft.atitle=A+prospective+study+of+polymorphisms+of+DNA+repair+genes+XRCC1%2C+XPD23+and+APE%2Fref-1+and+risk+of+stroke+in+Linxian%2C+China&rft.au=Mahabir%2C+Somdat%3BAbnet%2C+Christian+C%3BQiao%2C+You-Lin%3BRatnasinghe%2C+Luke+D%3BDawsey%2C+Sanford+M%3BDong%2C+Zhi-Wei%3BTaylor%2C+Philip+R%3BMark%2C+Steven+D&rft.aulast=Mahabir&rft.aufirst=Somdat&rft.date=2007-08-01&rft.volume=61&rft.issue=8&rft.spage=737&rft.isbn=&rft.btitle=&rft.title=Journal+of+Epidemiology+and+Community+Health&rft.issn=0143005X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; DNA damage; Gene polymorphism; X chromosome; Stroke; Codons; XRCC1 protein; DNA repair; Cancer; Models; Mortality; risk reduction; prevention; DNA; human populations; China, People's Rep. ER - TY - JOUR T1 - Effect of Human Papillomavirus 16/18 L1 Viruslike Particle Vaccine Among Young Women With Preexisting Infection: A Randomized Trial AN - 20723533; 7557288 AB - CONTEXT: Viruslike particle human papillomavirus (HPV) vaccines were designed to prevent HPV infection and development of cervical precancers and cancer. Women with oncogenic HPV infections might consider vaccination as therapy. OBJECTIVE: To determine whether vaccination against HPV types 16 and 18 increases the rate of viral clearance in women already infected with HPV. DESIGN AND SETTING: Phase 3, masked, community-based randomized trial conducted in 2 provinces of Costa Rica. PARTICIPANTS: A total of 2189 women aged 18 to 25 years who were recruited between June 2004 and December 2005. Participants were positive for HPV DNA at enrollment, had at least 6 months of follow-up, and had follow-up HPV DNA results. INTERVENTION: Participants were randomly assigned to receive 3 doses of a bivalent HPV-16/18 L1 protein viruslike particle AS04 candidate vaccine (n = 1088) or a control hepatitis A vaccine (n = 1101) over 6 months. MAIN OUTCOME MEASURES: Presence of HPV DNA was determined in cervical specimins by a molecular hybridization assay using chemiluminescence with HPV RNA probes and by polymerase chain reaction using SPF10 primers and a line probe assay detection system before vaccination and by polymerase chain reaction after vaccination. We compared rates of type-specific viral clearance using generalized estimating equations methods at the 6-month visit (after 2 doses) and 12-month visit (after 3 doses) in the 2 study groups. RESULTS: There was no evidence of increased viral clearance at 6 or 12 months in the group who received HPV vaccine compared with the control group. Clearance rates for HPV-16/18 infections at 6 months were 33.4% (82/248) in the HPV vaccine group and 31.6% (95/298) in the control group (vaccine efficacy for viral clearance, 2.5%; 95% confidence interval, -9.8% to 13.5%). Human papillomavirus 16/18 clearance rates at 12 months were 48.8% (86/177) in the HPV vaccine group and 49.8% (110/220) in the control group (vaccine efficacy for viral clearance, -2.0%; 95% confidence interval, -24.3% to 16.3%). There was no evidence of a therapeutic effect for other oncogenic or nononcogenic HPV categories, among women receiving all vaccine doses, among women with single infections, or among women stratified by the following entry variables: HPV-16/18 serology, cytologic results, HPV DNA viral load, time since sexual debut, Chlamydia trachomatis or Neisseria gonorrhoeae infection, hormonal contraceptive use, or smoking. CONCLUSION: In women positive for HPV DNA, HPV-16/18 vaccination does not accelerate clearance of the virus and should not be used to treat prevalent infections. Trial Registration clinicaltrials.gov Identifier: NCT00128661 JF - JAMA: Journal of the American Medical Association AU - Hildesheim, Allan AU - Herrero, Rolando AU - Wacholder, Sholom AU - Rodriguez, Ana C AU - Solomon, Diane AU - Bratti, MConcepcion AU - Schiller, John T AU - Gonzalez, Paula AU - Dubin, Gary AU - Porras, Carolina AU - Jimenez, Silvia E AU - Lowy, Douglas R AD - Division of Cancer Epidemiology and Genetics (Drs Hildesheim and Wacholder), Division of Cancer Prevention and Control (Dr Solomon), and Center for Cancer Research (Drs Schiller and Lowy), National Cancer Institute, Bethesda, Maryland Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 743 EP - 753 PB - American Medical Association, 515 N. State St. Chicago IL 60610 USA VL - 298 IS - 7 SN - 0098-7484, 0098-7484 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Mathematical models KW - DNA probes KW - Chlamydia trachomatis KW - Infection KW - Serology KW - Vaccination KW - Neisseria gonorrhoeae KW - Cancer KW - double prime L1 protein KW - Smoking KW - RNA probes KW - Human papillomavirus 16 KW - Hepatitis A KW - Polymerase chain reaction KW - Primers KW - Vaccines KW - Chemiluminescence KW - Cervix KW - Contraceptives KW - J 02350:Immunology KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20723533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA%3A+Journal+of+the+American+Medical+Association&rft.atitle=Effect+of+Human+Papillomavirus+16%2F18+L1+Viruslike+Particle+Vaccine+Among+Young+Women+With+Preexisting+Infection%3A+A+Randomized+Trial&rft.au=Hildesheim%2C+Allan%3BHerrero%2C+Rolando%3BWacholder%2C+Sholom%3BRodriguez%2C+Ana+C%3BSolomon%2C+Diane%3BBratti%2C+MConcepcion%3BSchiller%2C+John+T%3BGonzalez%2C+Paula%3BDubin%2C+Gary%3BPorras%2C+Carolina%3BJimenez%2C+Silvia+E%3BLowy%2C+Douglas+R&rft.aulast=Hildesheim&rft.aufirst=Allan&rft.date=2007-08-01&rft.volume=298&rft.issue=7&rft.spage=743&rft.isbn=&rft.btitle=&rft.title=JAMA%3A+Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Mathematical models; DNA probes; Infection; Vaccination; Serology; Cancer; double prime L1 protein; Smoking; RNA probes; Polymerase chain reaction; Hepatitis A; Primers; Vaccines; Cervix; Chemiluminescence; Contraceptives; Human papillomavirus 16; Chlamydia trachomatis; Neisseria gonorrhoeae ER - TY - JOUR T1 - Polymorphisms in Apoptosis and Cell Cycle Control Genes and Risk of Brain Tumors in Adults AN - 20720908; 7555870 AB - Despite the potential importance of the cell cycle and apoptosis pathways in brain tumor etiology, little has been published regarding brain tumor risk associated with common gene variants in these pathways. Using data from a hospital-based case-control study conducted by the National Cancer Institute between 1994 and 1998, we evaluated risk of glioma (n = 388), meningioma (n = 162), and acoustic neuroma (n = 73) with respect to 12 single nucleotide polymorphisms from 10 genes involved in apoptosis and cell cycle control: CASP8, CCND1, CCNH, CDKN1A, CDKN2A, CHEK1, CHEK2, MDM2, PTEN, and TP53. We observed significantly decreased risk of meningioma with the CASP8 Ex14-271A>T variant [odds ratio (OR) sub(AT), 0.8; 95% confidence interval (95% CI), 0.5-1.2; OR sub(AA), 0.5; 95% CI, 0.3-0.9; P sub(trend) = 0.03] and increased risk of meningioma with the CASP8 Ex13+51G>C variant (OR sub(GC), 1.4; 95% CI, 0.9-2.1; OR sub(CC), 3.6; 95% CI, 1.0-13.1; P sub(trend) = 0.04). The CT haplotype of the two CASP8 polymorphisms was associated with significantly increased risk of meningioma (OR, 1.7; 95% CI, 1.1-2.6), but was not associated with risk of glioma or acoustic neuroma. The CCND1 Ex4-1G>A variant was associated with increased risk for glioma, and the Ex8+49T>C variant of CCNH was associated with increased risk of glioma and acoustic neuroma. The MDM2 Ex12+162A>G variant was associated with significantly reduced risk of glioma. Our results suggest that common variants in the CASP8, CCND1, CCNH, and MDM2 genes may influence brain tumor risk. Future research in this area should include more detailed coverage of genes in the apoptosis/cell cycle control pathways. (Cancer Epidemiol Biomarkers Prev 2007; 16(8):1655-61) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Rajaraman, Preetha AU - Wang, Sophia S AU - Rothman, Nathaniel AU - Brown, Merideth M AU - Black, Peter M AU - Fine, Howard A AU - Loeffler, Jay S AU - Selker, Robert G AU - Shapiro, William R AU - Chanock, Stephen J AU - Inskip, Peter D AD - Division of Cancer Epidemiology and Genetics, Core Genotyping Facility, Neuro-oncology Branch, and Pediatric Oncology Branch, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 1655 EP - 1661 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 8 SN - 1055-9965, 1055-9965 KW - Genetics Abstracts; Risk Abstracts; CSA Neurosciences Abstracts KW - Apoptosis KW - Gene polymorphism KW - Cell cycle KW - PTEN protein KW - Neoplasia KW - glioma KW - risk reduction KW - Haplotypes KW - prevention KW - Glioma KW - brain tumors KW - Bioindicators KW - MDM2 protein KW - Etiology KW - Data processing KW - haplotypes KW - biomarkers KW - Cancer KW - p53 protein KW - Brain tumors KW - Single-nucleotide polymorphism KW - France, Aquitaine, Oraas KW - meningioma KW - N3 11023:Neurogenetics KW - R2 23060:Medical and environmental health KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20720908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Polymorphisms+in+Apoptosis+and+Cell+Cycle+Control+Genes+and+Risk+of+Brain+Tumors+in+Adults&rft.au=Rajaraman%2C+Preetha%3BWang%2C+Sophia+S%3BRothman%2C+Nathaniel%3BBrown%2C+Merideth+M%3BBlack%2C+Peter+M%3BFine%2C+Howard+A%3BLoeffler%2C+Jay+S%3BSelker%2C+Robert+G%3BShapiro%2C+William+R%3BChanock%2C+Stephen+J%3BInskip%2C+Peter+D&rft.aulast=Rajaraman&rft.aufirst=Preetha&rft.date=2007-08-01&rft.volume=16&rft.issue=8&rft.spage=1655&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - MDM2 protein; Etiology; Data processing; Apoptosis; Gene polymorphism; Cell cycle; PTEN protein; biomarkers; Neoplasia; p53 protein; Brain tumors; Haplotypes; Single-nucleotide polymorphism; Glioma; meningioma; Bioindicators; risk reduction; glioma; prevention; haplotypes; brain tumors; Cancer; France, Aquitaine, Oraas ER - TY - JOUR T1 - Transduction of Rhesus Macaque Hematopoietic Stem and Progenitor Cells with Avian Sarcoma and Leukosis Viral Vectors AN - 20704325; 7588538 AB - Genome-wide integration site analyses showed that Moloney murine leukemia virus (MoMLV)- and lentivirus-derived vectors integrate preferentially into the coding regions of genes, posing a risk of insertional mutagenesis. Avian sarcoma and leukosis viruses (ASLVs) were previously reported to have a weak preference for gene-coding regions in a cell line study as compared with human immunodeficiency virus and MoMLV; however, thus far these vectors have not been studied for their potential efficacy in transduction of hematopoietic progenitor and stem cells. In this study we investigated for the first time the ability of ASLV-derived RCAS (replication-competent ALV LTR [avian leukosis virus long terminal repeat] with a splice acceptor) vectors to transduce rhesus macaque hematopoietic progenitors and long-term repopulating cells, in an autologous transplantation model. RCAS vectors can efficiently and stably transduce rhesus macaque CD34+ hematopoietic progenitor cells with an efficiency of transduction of up to 34% ex vivo. In two animals transplanted with RCAS vector-transduced autologous CD34 super(+) cells, highly polyclonal hematopoietic reconstitution with sustained gene-marking levels in myeloid and lymphoid lineages was observed up to 18 months post-transplantation. These findings are encouraging and suggest that this vector system should be explored and further optimized for gene therapy applications targeting hematopoietic stem and progenitor cells. JF - Human Gene Therapy AU - Hu, J AU - Ferris, A AU - Larochelle, A AU - Krouse, A E AU - Metzger, ME AU - Donahue, R E AU - Hughes, SH AU - Dunbar, CE AD - Molecular Hematopoiesis Section, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1202, dunbarc@nhlbi.nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 691 EP - 700 VL - 18 IS - 8 SN - 1043-0342, 1043-0342 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Autografts KW - Moloney murine leukemia virus KW - Gene therapy KW - Long terminal repeat KW - Animal models KW - Avian leukosis KW - CD34 antigen KW - Expression vectors KW - Integration KW - Avian leukosis virus KW - Stem cells KW - Leukosis KW - Human immunodeficiency virus KW - insertional mutagenesis KW - Sarcoma KW - Hemopoiesis KW - Macaca mulatta KW - Avian sarcoma and leukosis virus KW - W 30905:Medical Applications KW - V 22360:AIDS and HIV KW - F 06950:Immunogenetics, MHC, HLA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20704325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Transduction+of+Rhesus+Macaque+Hematopoietic+Stem+and+Progenitor+Cells+with+Avian+Sarcoma+and+Leukosis+Viral+Vectors&rft.au=Hu%2C+J%3BFerris%2C+A%3BLarochelle%2C+A%3BKrouse%2C+A+E%3BMetzger%2C+ME%3BDonahue%2C+R+E%3BHughes%2C+SH%3BDunbar%2C+CE&rft.aulast=Hu&rft.aufirst=J&rft.date=2007-08-01&rft.volume=18&rft.issue=8&rft.spage=691&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2006.175 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Autografts; Gene therapy; Long terminal repeat; Animal models; CD34 antigen; Avian leukosis; Expression vectors; Integration; Stem cells; Leukosis; insertional mutagenesis; Sarcoma; Hemopoiesis; Avian leukosis virus; Moloney murine leukemia virus; Human immunodeficiency virus; Macaca mulatta; Avian sarcoma and leukosis virus DO - http://dx.doi.org/10.1089/hum.2006.175 ER - TY - JOUR T1 - Cutaneous phenotype and MC1R variants as modifying factors for the development of melanoma in CDKN2A G101W mutation carriers from 4 countries AN - 20650251; 8079549 AB - The G101W founder mutation is the most common CDKN2A mutation in Italy, Spain, and France. As the background of modifying genes, environmental exposures, and sun behavior vary across countries, studying G101W carriers from distinct countries offers a unique opportunity to evaluate possible modifying factors in melanoma development. We evaluated 76 G101W cases and 59 carrier controls from France, Italy, Spain, and the United States. Hair color and dysplastic nevi distributions differed significantly in cases and controls across the 4 study groups. Cases also varied significantly for eye color, freckling, and nevi. The distribution of MC1R variants in cases differed significantly across study groups because 12% of Italian melanoma patients had 2 MC1R variants vs. >50% for the other case groups. Several MC1R covariates showed significant associations with melanoma risk in all groups combined and in the American, French, and Spanish samples; no significant findings were observed in the Italian sample. In multiple-case families, the number and type of MC1R variants varied significantly between multiple-primary-melanoma and single-primary-melanoma patients from the 4 groups; there was also a significant decrease in median age at melanoma diagnosis as the number or type of MC1R variants increased. The variation in the effects of the cutaneous phenotypic and MC1R factors across the study sample suggests that these factors differentially contribute to development of melanoma even on a common genetic background of a germline CDKN2A mutation. Differences in melanoma risk across geographic regions justify the need for individual studies in each country before counseling should be considered. JF - International Journal of Cancer AU - Goldstein, Alisa M AU - Chaudru, Valerie AU - Ghiorzo, Paola AU - Badenas, Celia AU - Malvehy, Josep AU - Pastorino, Lorenza AU - Laud, Karine AU - Hulley, Benjamin AU - Avril, Marie-Francoise AU - Puig-Butille, Joan A AU - Miniere, Annie AU - Marti, Rosa AU - Chompret, Agnes AU - Cuellar, Francisco AU - Kolm, Isabel AU - Mila, Montserrat AU - Tucker, Margaret A AU - Demenais, Florence AU - Bianchi-Scarra, Giovanna AU - Puig, Susana AU - de-Paillerets, Brigitte Bressac AD - Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, goldstea@exchange.nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 825 EP - 831 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 121 IS - 4 SN - 0020-7136, 0020-7136 KW - Genetics Abstracts; Risk Abstracts KW - Age KW - Eye KW - Spain KW - melanoma KW - Hair KW - Italy KW - Cancer KW - Melanoma KW - Color KW - France KW - USA KW - Sun KW - Mutation KW - R2 23060:Medical and environmental health KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20650251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Cutaneous+phenotype+and+MC1R+variants+as+modifying+factors+for+the+development+of+melanoma+in+CDKN2A+G101W+mutation+carriers+from+4+countries&rft.au=Goldstein%2C+Alisa+M%3BChaudru%2C+Valerie%3BGhiorzo%2C+Paola%3BBadenas%2C+Celia%3BMalvehy%2C+Josep%3BPastorino%2C+Lorenza%3BLaud%2C+Karine%3BHulley%2C+Benjamin%3BAvril%2C+Marie-Francoise%3BPuig-Butille%2C+Joan+A%3BMiniere%2C+Annie%3BMarti%2C+Rosa%3BChompret%2C+Agnes%3BCuellar%2C+Francisco%3BKolm%2C+Isabel%3BMila%2C+Montserrat%3BTucker%2C+Margaret+A%3BDemenais%2C+Florence%3BBianchi-Scarra%2C+Giovanna%3BPuig%2C+Susana%3Bde-Paillerets%2C+Brigitte+Bressac&rft.aulast=Goldstein&rft.aufirst=Alisa&rft.date=2007-08-01&rft.volume=121&rft.issue=4&rft.spage=825&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22712 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Age; Eye; Sun; Hair; Mutation; Color; Melanoma; melanoma; Cancer; France; USA; Spain; Italy DO - http://dx.doi.org/10.1002/ijc.22712 ER - TY - JOUR T1 - Enhanced Sensitivity to Cholera Toxin in ADP-Ribosylarginine Hydrolase-Deficient Mice AN - 20637528; 7532365 AB - Cholera toxin (CT) produced by Vibrio cholerae causes the devastating diarrhea of cholera by catalyzing the ADP-ribosylation of the alpha subunit of the intestinal G sub(s) protein (G sub(s alpha )), leading to characteristic water and electrolyte losses. Mammalian cells contain ADP-ribosyltransferases similar to CT and an ADP-ribosyl(arginine)protein hydrolase (ADPRH), which cleaves the ADP-ribose-(arginine)protein bond, regenerating native protein and completing an ADP-ribosylation cycle. We hypothesized that ADPRH might counteract intoxication by reversing the ADP-ribosylation of G sub(s alpha ). Effects of intoxication on murine ADPRH super(-/-) cells were greater than those on wild-type cells and were significantly reduced by overexpression of wild-type ADPRH in ADPRH super(-/-) cells, as evidenced by both ADP-ribose-arginine content and G sub(s alpha ) modification. Similarly, intestinal loops in the ADPRH super(-/-) mouse were more sensitive than their wild-type counterparts to toxin effects on fluid accumulation, G sub(s alpha ) modification, and ADP-ribosylarginine content. Thus, CT-catalyzed ADP-ribosylation of cell proteins can be counteracted by ADPRH, which could function as a modifier gene in disease. Further, our study demonstrates that enzymatic cross talk exists between bacterial toxin ADP-ribosyltransferases and host ADP-ribosylation cycles. In disease, toxin-catalyzed ADP-ribosylation overwhelms this potential host defense system, resulting in persistence of ADP-ribosylation and intoxication of the cell. JF - Molecular and Cellular Biology AU - Kato, Jiro AU - Zhu, Jianfeng AU - Liu, Chengyu AU - Moss, Joel AD - Pulmonary-Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1590. Laboratory Research Program, Transgenic Mouse Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1590 Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 5534 EP - 5543 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 27 IS - 15 SN - 0270-7306, 0270-7306 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology KW - Intoxication KW - hydrolase KW - Vibrio cholerae KW - Diarrhea KW - Mammalian cells KW - NAD(P) super(+)-arginine ADP-ribosyltransferase KW - Cholera toxin KW - Intestine KW - Guanine nucleotide-binding protein KW - Cholera KW - ADP-ribosylation KW - X 24370:Natural Toxins KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20637528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biology&rft.atitle=Enhanced+Sensitivity+to+Cholera+Toxin+in+ADP-Ribosylarginine+Hydrolase-Deficient+Mice&rft.au=Kato%2C+Jiro%3BZhu%2C+Jianfeng%3BLiu%2C+Chengyu%3BMoss%2C+Joel&rft.aulast=Kato&rft.aufirst=Jiro&rft.date=2007-08-01&rft.volume=27&rft.issue=15&rft.spage=5534&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - hydrolase; Intoxication; Diarrhea; Mammalian cells; Cholera toxin; NAD(P) super(+)-arginine ADP-ribosyltransferase; Intestine; Guanine nucleotide-binding protein; Cholera; ADP-ribosylation; Vibrio cholerae ER - TY - JOUR T1 - High-throughput screening assays for the identification of chemical probes AN - 20635607; 7565441 AB - High-throughput screening (HTS) assays enable the testing of large numbers of chemical substances for activity in diverse areas of biology. The biological responses measured in HTS assays span isolated biochemical systems containing purified receptors or enzymes to signal transduction pathways and complex networks functioning in cellular environments. This Review addresses factors that need to be considered when implementing assays for HTS and is aimed particularly at investigators new to this field. We discuss assay design strategies, the major detection technologies and examples of HTS assays for common target classes, cellular pathways and simple cellular phenotypes. We conclude with special considerations for configuring sensitive, robust, informative and economically feasible HTS assays. JF - Nature Chemical Biology AU - Inglese, James AU - Johnson, Ronald L AU - Simeonov, Anton AU - Xia, Menghang AU - Zheng, Wei AU - Austin, Christopher P AU - Auld, Douglas S AD - US National Institutes of Health Chemical Genomics Center, National Institutes of Health, 9800 Medical Center Drive, Bethesda, Maryland 20892- 3370, USA., jinglese@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 466 EP - 479 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 3 IS - 8 SN - 1552-4450, 1552-4450 KW - Biotechnology and Bioengineering Abstracts KW - Reviews KW - Enzymes KW - high-throughput screening KW - Signal transduction KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20635607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Chemical+Biology&rft.atitle=High-throughput+screening+assays+for+the+identification+of+chemical+probes&rft.au=Inglese%2C+James%3BJohnson%2C+Ronald+L%3BSimeonov%2C+Anton%3BXia%2C+Menghang%3BZheng%2C+Wei%3BAustin%2C+Christopher+P%3BAuld%2C+Douglas+S&rft.aulast=Inglese&rft.aufirst=James&rft.date=2007-08-01&rft.volume=3&rft.issue=8&rft.spage=466&rft.isbn=&rft.btitle=&rft.title=Nature+Chemical+Biology&rft.issn=15524450&rft_id=info:doi/10.1038%2Fnchembio.2007.17 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Reviews; Enzymes; high-throughput screening; Signal transduction DO - http://dx.doi.org/10.1038/nchembio.2007.17 ER - TY - JOUR T1 - Comparing measures of acute bowel toxicity in patients with prostate cancer treated with external beam radiation therapy AN - 20541994; 8067564 AB - Purpose This study strives to compare early measures of bowel toxicity in patients with prostate cancer receiving definitive or adjuvant 3D conformal external beam radiation therapy and concurrent daily endorectal application of amifostine. Methods Eighteen patients were enrolled in the clinical study with a median follow-up of 12 months. Prescription doses ranged from 66 Gy to 76 Gy with a daily fractionation of 2 Gy. Acute bowel toxicity was measured at baseline, at Weeks 5 and 7 of radiotherapy, and at 1 and 3 months after the completion of therapy. Measures of acute bowel toxicity included the Radiation Therapy Oncology Group (RTOG) acute radiation morbidity scoring criteria, Expanded Prostate Cancer Index Composite (EPIC) self-assessment questionnaires, and proctoscopic examinations. Results The mean EPIC bowel scores changed significantly through the course of therapy and follow-up (p < 0.0001), with a progressive decrease in scores at Weeks 5 and 7 of treatment, a partial recovery at 3 months, and a correlation to the gold standard RTOG grade (p = 0.004). Proctoscopic toxicity scores were low, did not vary over time, and did not correlate with either EPIC or RTOG scores. Conclusion The EPIC questionnaire measurements are most sensitive to changes in acute bowel toxicity through a course of radiotherapy and correlate with RTOG acute toxicity scores. Endoscopic examination of the rectal mucosa at the end and immediate follow-up of a course of therapy does not seem to be informative or reproducible between observers in the acute setting. JF - International Journal of Radiation Oncology, Biology, & Physics AU - Muanza, Thierry M AU - Albert, Paul S AU - Smith, Sharon AU - Godette, Denise AU - Crouse, Nancy Sears AU - Cooley-Zgela, Theresa AU - Sciuto, Linda AU - Camphausen, Kevin AU - Coleman, C Norman AU - Menard, Cynthia AD - Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, cynthia.menard@rmp.uhn.on.ca Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 1316 EP - 1321 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 62 IS - 5 SN - 0360-3016, 0360-3016 KW - Toxicology Abstracts KW - Bowel toxicity KW - Radiation KW - Endoscopy KW - Prostate cancer KW - Inventories KW - Rectum KW - Amifostine KW - Mucosa KW - Radiotherapy KW - Oncology KW - Acute toxicity KW - Adjuvants KW - Self-assessment KW - Morbidity KW - Intestine KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20541994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Radiation+Oncology%2C+Biology%2C+%26+Physics&rft.atitle=Comparing+measures+of+acute+bowel+toxicity+in+patients+with+prostate+cancer+treated+with+external+beam+radiation+therapy&rft.au=Muanza%2C+Thierry+M%3BAlbert%2C+Paul+S%3BSmith%2C+Sharon%3BGodette%2C+Denise%3BCrouse%2C+Nancy+Sears%3BCooley-Zgela%2C+Theresa%3BSciuto%2C+Linda%3BCamphausen%2C+Kevin%3BColeman%2C+C+Norman%3BMenard%2C+Cynthia&rft.aulast=Muanza&rft.aufirst=Thierry&rft.date=2007-08-01&rft.volume=62&rft.issue=5&rft.spage=1316&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Radiation+Oncology%2C+Biology%2C+%26+Physics&rft.issn=03603016&rft_id=info:doi/10.1016%2Fj.ijrobp.2004.12.083 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Inventories; Rectum; Amifostine; Mucosa; Radiotherapy; Oncology; Self-assessment; Adjuvants; Acute toxicity; Morbidity; Prostate cancer; Radiation; Intestine DO - http://dx.doi.org/10.1016/j.ijrobp.2004.12.083 ER - TY - JOUR T1 - Imaging and manipulating phosphoinositides in living cells AN - 20513543; 8007802 AB - Phosphoinositides are minor phospholipid constituents of virtually every biological membrane yet they play fundamental roles in controlling membrane-bound signalling events. Phosphoinositides are produced from phosphatidylinositol (PtdIns) by phosphorylation of one or more of three positions (3, 4 and 5) of the inositol headgroup located at the membrane cytoplasmic interface by distinct families of inositol lipid kinases. Intriguingly, many of the kinase reactions are catalysed by more than one form of the kinases even in simple organisms and these enzymes often assume non-redundant functions. A similar diversity is seen with inositide phosphatases, the enzymes that dephosphorylate phosphoinositides with a certain degree of specificity and the impairments of which are often linked to human diseases. This degree of multiplicity at the enzyme level together with the universal roles of these lipids in cell regulation assumes that inositol lipids are spatially and functionally restricted in specific membrane compartments. Studying the compartmentalized roles of these lipids at the cellular level represents a major methodological challenge. Over the last 10 years significant progress has been made in creating reagents that can monitor inositol lipid changes in live cells with fluorescence or confocal microscopy. New methods are also being developed to manipulate these lipids in specific membrane compartments in a regulated fashion. This article recalls some historical aspects of inositide research and describes the new methodological advances highlighting their great potential as well as the problems one can encounter with their use. JF - Journal of Physiology (London) AU - Balla, Tamas AD - National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA, ballat@mail.nih.gov Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 927 EP - 937 PB - Cambridge University Press, The Edinburgh Building, VL - 582 IS - 3 SN - 0022-3751, 0022-3751 KW - Biotechnology Research Abstracts (through 1992) KW - Lipid kinase KW - Fluorescence KW - Phosphorylation KW - phosphatidylinositol KW - Computed tomography KW - Confocal microscopy KW - Inositol KW - Enzymes KW - phosphoinositides KW - Phospholipids KW - Signal transduction KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20513543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Physiology+%28London%29&rft.atitle=Imaging+and+manipulating+phosphoinositides+in+living+cells&rft.au=Balla%2C+Tamas&rft.aulast=Balla&rft.aufirst=Tamas&rft.date=2007-08-01&rft.volume=582&rft.issue=3&rft.spage=927&rft.isbn=&rft.btitle=&rft.title=Journal+of+Physiology+%28London%29&rft.issn=00223751&rft_id=info:doi/10.1113%2Fjphysiol.2007.132795 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Inositol; phosphoinositides; Enzymes; Lipid kinase; phosphatidylinositol; Confocal microscopy; Computed tomography; Signal transduction; Fluorescence; Phospholipids; Phosphorylation DO - http://dx.doi.org/10.1113/jphysiol.2007.132795 ER - TY - JOUR T1 - Immunological properties of engineered nanomaterials AN - 20504337; 7565628 AB - Most research on the toxicology of nanomaterials has focused on the effects of nanoparticles that enter the body accidentally. There has been much less research on the toxicology of nanoparticles that are used for biomedical applications, such as drug delivery or imaging, in which the nanoparticles are deliberately placed in the body. Moreover, there are no harmonized standards for assessing the toxicity of nanoparticles to the immune system (immunotoxicity). Here we review recent research on immunotoxicity, along with data on a range of nanotechnology-based drugs that are at different stages in the approval process. Research shows that nanoparticles can stimulate and/or suppress the immune responses, and that their compatibility with the immune system is largely determined by their surface chemistry. Modifying these factors can significantly reduce the immunotoxicity of nanoparticles and make them useful platforms for drug delivery. JF - Nature Nanotechnology AU - Dobrovolskaia, Marina A AU - McNeil, Scott E Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 469 EP - 478 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 2 IS - 8 SN - 1748-3387, 1748-3387 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Nanoparticles KW - Nanomedicine KW - Drug delivery KW - Immunotoxicity KW - Immune system KW - Reviews KW - nanoparticles KW - imaging KW - Immunosuppressive agents KW - nanotechnology KW - F 06955:Immunomodulation & Immunopharmacology KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20504337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Nanotechnology&rft.atitle=Immunological+properties+of+engineered+nanomaterials&rft.au=Dobrovolskaia%2C+Marina+A%3BMcNeil%2C+Scott+E&rft.aulast=Dobrovolskaia&rft.aufirst=Marina&rft.date=2007-08-01&rft.volume=2&rft.issue=8&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Nature+Nanotechnology&rft.issn=17483387&rft_id=info:doi/10.1038%2Fnnano.2007.223 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Drug delivery; Immunotoxicity; Reviews; Immune system; Immunosuppressive agents; imaging; nanoparticles; nanotechnology DO - http://dx.doi.org/10.1038/nnano.2007.223 ER - TY - JOUR T1 - Factors Associated with Retaliatory Attitudes among African American Adolescents Who have been Assaulted AN - 20435559; 7532185 AB - OBJECTIVE:s (a) To describe attitudes regarding retaliation among adolescents who have been assaulted. (b) To examine assault/event characteristics, personal, parental, and environmental factors associated with the retaliatory attitudes of adolescents who have been assaulted. METHODS:African American youth aged 10-15 years presenting to two large urban hospitals with peer assault injury and a parent/caregiver completed interviews in their home after their emergency department visit. RESULTS:Multivariate analyses revealed that lower SES, older age, and adolescents' perceptions that their parents support fighting were related to endorsing retaliatory attitudes. Girls who were aggressive were more likely to endorse retaliatory attitudes. However, level of aggression did not impact boys' retaliatory attitudes. Affiliating with aggressive peers influenced the retaliatory attitudes of boys, but did not influence girls' retaliatory attitudes. Overall, youths' perceptions of their parents' attitudes toward fighting had the greatest impact on retaliatory attitudes. CONCLUSIONS:Adolescents' perceptions of their parents' attitudes toward fighting may be a factor in subsequent re-injury among youth. Violence prevention and intervention efforts need to involve components that assess parental attitudes and incorporate strategies to engage parents in violence prevention efforts. In addition, interventions for youth who have been assaulted may need to incorporate some gender-specific components in order to address the unique needs of girls and boys. JF - Journal of Pediatric Psychology AU - Copeland-Linder, Nikeea AU - Jones, Vanya C AU - Haynie, Denise L AU - Simons-Morton, Bruce G AU - Wright, Joseph L AU - Cheng, Tina L AD - Johns Hopkins University School of Medicine & Johns Hopkins Bloomberg School of Public Health, Johns Hopkins Bloomberg School of Public Health, NICHD/PRB/DESPR/NIH, Children's National Medical Center, and Johns Hopkins University School of Medicine Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 760 EP - 770 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 32 IS - 7 SN - 0146-8693, 0146-8693 KW - retaliation KW - Risk Abstracts KW - Prevention KW - Gender KW - Violence KW - Ethnic groups KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20435559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pediatric+Psychology&rft.atitle=Factors+Associated+with+Retaliatory+Attitudes+among+African+American+Adolescents+Who+have+been+Assaulted&rft.au=Copeland-Linder%2C+Nikeea%3BJones%2C+Vanya+C%3BHaynie%2C+Denise+L%3BSimons-Morton%2C+Bruce+G%3BWright%2C+Joseph+L%3BCheng%2C+Tina+L&rft.aulast=Copeland-Linder&rft.aufirst=Nikeea&rft.date=2007-08-01&rft.volume=32&rft.issue=7&rft.spage=760&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pediatric+Psychology&rft.issn=01468693&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Prevention; Gender; Violence; Ethnic groups ER - TY - JOUR T1 - Does cannabis use predict the first incidence of mood and anxiety disorders in the adult population? AN - 20418257; 7884081 AB - Aims To investigate whether cannabis use predicted the first incidence of mood and anxiety disorders in adults during a 3-year follow-up period. Design and participants Data were derived from the Netherlands Mental Health Survey and Incidence Study (NEMESIS), a prospective study in the adult population of 18-64 years. The analysis was carried out on 3881 people who had no life-time mood disorders and on 3854 people who had no life-time anxiety disorders at baseline. Measurements Life-time cannabis use and DSM-III-R mood and anxiety disorders, assessed with the Composite International Diagnostic Interview (CIDI). Findings After adjustment for strong confounders, any use of cannabis at baseline predicted a modest increase in the risk of a first major depression (odds ratio 1.62; 95% confidence interval 1.06-2.48) and a stronger increase in the risk of a first bipolar disorder (odds ratio 4.98; 95% confidence interval 1.80-13.81). The risk of 'any mood disorder' was elevated for weekly and almost daily users but not for less frequent use patterns. However, dose-response relationships were less clear for major depression and bipolar disorder separately. None of the associations between cannabis use and anxiety disorders remained significant after adjustment for confounders. Conclusions The associations between cannabis use and the first incidence of depression and bipolar disorder, which remained significant after adjustment for strong confounders, warrant research into the underlying mechanisms. JF - Addiction AU - van Laar, Margriet AU - van Dorsselaer, Saskia AU - Monshouwer, Karin AU - de Graaf, Ron AD - Trimbos Institute, Netherlands National Institute of Mental Health and Addiction, Utrecht, the Netherlands, mlaar@trimbos.nl Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 1251 EP - 1260 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 102 IS - 8 SN - 0965-2140, 0965-2140 KW - Toxicology Abstracts KW - Anxiety disorders KW - bipolar disorder KW - cannabis abuse KW - major depressive disorder KW - mood disorders KW - Mood KW - Mental disorders KW - Nemesis KW - Depression KW - Anxiety KW - Bipolar disorder KW - Dose-response effects KW - Cannabis KW - Addiction KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20418257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Does+cannabis+use+predict+the+first+incidence+of+mood+and+anxiety+disorders+in+the+adult+population%3F&rft.au=van+Laar%2C+Margriet%3Bvan+Dorsselaer%2C+Saskia%3BMonshouwer%2C+Karin%3Bde+Graaf%2C+Ron&rft.aulast=van+Laar&rft.aufirst=Margriet&rft.date=2007-08-01&rft.volume=102&rft.issue=8&rft.spage=1251&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2007.01875.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mood; Mental disorders; Depression; Anxiety; Bipolar disorder; Dose-response effects; Cannabis; Addiction; Nemesis DO - http://dx.doi.org/10.1111/j.1360-0443.2007.01875.x ER - TY - JOUR T1 - A Receptor-binding Site as Revealed by the Crystal Structure of CfaE, the Colonization Factor Antigen I Fimbrial Adhesin of Enterotoxigenic Escherichia coli AN - 20396743; 7557660 AB - CfaE is the minor, tip-localized adhesive subunit of colonization factor antigen I fimbriae (CFA/I) of enterotoxigenic Escherichia coli and is thought to be essential for the attachment of enterotoxigenic E. coli to the human small intestine early in diarrhea pathogenesis. The crystal structure of an in cis donor strand complemented CfaE was determined, providing the first atomic view of a fimbrial subunit assembled by the alternate chaperone pathway. The in cis donor strand complemented variant of CfaE structure consists of an N-terminal adhesin domain and a C-terminal pilin domain of similar size, each featuring a variable immunoglobulin-like fold. Extensive interactions exist between the two domains and appear to rigidify the molecule. The upper surface of the adhesin domain distal to the pilin domain reveals a depression consisting of conserved residues including Arg super(181), previously shown to be necessary for erythrocyte adhesion. Mutational analysis revealed a cluster of conserved, positively charged residues that are required for CFA/I-mediated hemagglutination, implicating this as the receptor-binding pocket. Mutations in a few subclass-specific residues that surround the cluster displayed differential effects on the two red cell species used in hemagglutination, suggesting that these residues play a role in host or cell specificity. The C-terminal donor strand derived from the major subunit CfaB is folded as a beta -strand and fits into a hydrophobic groove in the pilin domain to complete the immunoglobulin fold. The location of this well ordered donor strand suggests the positioning and orientation of the subjacent major fimbrial subunit CfaB in the native assembly of CFA/I fimbriae. JF - Journal of Biological Chemistry AU - Li, Yong-Fu AU - Poole, Steven AU - Rasulova, Fatima AU - McVeigh, Annette L AU - Savarino, Stephen J AU - Xia, Di AD - Laboratory of Cell Biology, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892-4256, the Enteric Diseases Department, Infectious Diseases Directorate, Naval Medical Research Center, Silver Spring, Maryland 20910-7500, and the Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799 Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 23970 EP - 23980 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 33 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology KW - Adhesins KW - Depression KW - Diarrhea KW - pilin KW - Erythrocytes KW - Hydrophobicity KW - Small intestine KW - Hemagglutination KW - Pili KW - Escherichia coli KW - Crystal structure KW - Chaperones KW - Adhesives KW - Mutation KW - Colonization factor KW - Immunoglobulins KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20396743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=A+Receptor-binding+Site+as+Revealed+by+the+Crystal+Structure+of+CfaE%2C+the+Colonization+Factor+Antigen+I+Fimbrial+Adhesin+of+Enterotoxigenic+Escherichia+coli&rft.au=Li%2C+Yong-Fu%3BPoole%2C+Steven%3BRasulova%2C+Fatima%3BMcVeigh%2C+Annette+L%3BSavarino%2C+Stephen+J%3BXia%2C+Di&rft.aulast=Li&rft.aufirst=Yong-Fu&rft.date=2007-08-01&rft.volume=282&rft.issue=33&rft.spage=23970&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Adhesins; Diarrhea; Depression; pilin; Erythrocytes; Small intestine; Hydrophobicity; Hemagglutination; Pili; Crystal structure; Chaperones; Adhesives; Mutation; Colonization factor; Immunoglobulins; Escherichia coli ER - TY - JOUR T1 - Cell microarray platform for anticancer drug development AN - 20379985; 7761837 AB - Pharmacodynamic assessment of whether a drug has interacted with and modified its target is an essential component of molecularly targeted clinical trials. Although many trials are written with the intent to assess tumor biopsies, if available, thus far the great majority of early drug trials have used peripheral blood mononuclear cells (PBMC) as a tumor surrogate. Typically, PBMC are studied by low-throughput techniques such as Western blot. We present the use of a cell-based tissue microarray for assessment of anticancer drug activity in vivo. We demonstrate the utility of this technique for analysis of protein hyperacetylation in response to treatment with the histone deacetylase inhibitor, SNDX-275 in PBMC treated in vitro and in PBMC and bone marrow aspirates from patients in Phase I clinical trials with SNDX-275. We demonstrate that the cell microarray can be used to measure drug response in a high-throughput manner, allowing analysis of an entire trial on one or two glass slides. The cell microarray technique brings the advantages of the tissue microarray platform to the pharmacodynamic assessment of single cells, such as those isolated from bone marrow aspirates, fine needle aspirates, or malignant effusions, and to analysis of PBMC, the most commonly studied surrogate in oncology trials. JF - Drug Development Research AU - Lee, Min-Jung AU - Chung, Eun Joo AU - Lee, Sunmin AU - Chung, Joon-Yong AU - Telford, William G AU - Sausville, Edward A AU - Gojo, Ivana AU - Karp, Judith E AU - Gore, Steven D AU - Kapoor, Veena AU - Kim, Yeong Sang AU - Kummar, Shivaani AU - Gutierrez, Martin AU - Hewitt, Stephen M AU - Trepel, Jane B AD - Medical Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, trepel@helix.nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 226 EP - 234 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 68 IS - 5 SN - 0272-4391, 0272-4391 KW - Biotechnology and Bioengineering Abstracts KW - Western blotting KW - Histone deacetylase KW - Bone marrow KW - Effusion KW - Drug development KW - Biopsy KW - Oncology KW - Tumors KW - Drug screening KW - Clinical trials KW - Peripheral blood mononuclear cells KW - Pharmacodynamics KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20379985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Development+Research&rft.atitle=Cell+microarray+platform+for+anticancer+drug+development&rft.au=Lee%2C+Min-Jung%3BChung%2C+Eun+Joo%3BLee%2C+Sunmin%3BChung%2C+Joon-Yong%3BTelford%2C+William+G%3BSausville%2C+Edward+A%3BGojo%2C+Ivana%3BKarp%2C+Judith+E%3BGore%2C+Steven+D%3BKapoor%2C+Veena%3BKim%2C+Yeong+Sang%3BKummar%2C+Shivaani%3BGutierrez%2C+Martin%3BHewitt%2C+Stephen+M%3BTrepel%2C+Jane+B&rft.aulast=Lee&rft.aufirst=Min-Jung&rft.date=2007-08-01&rft.volume=68&rft.issue=5&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Drug+Development+Research&rft.issn=02724391&rft_id=info:doi/10.1002%2Fddr.20183 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Histone deacetylase; Western blotting; Peripheral blood mononuclear cells; Bone marrow; Effusion; Oncology; Biopsy; Drug development; Tumors; Drug screening; Clinical trials; Pharmacodynamics DO - http://dx.doi.org/10.1002/ddr.20183 ER - TY - JOUR T1 - Tissue microarrays enabling high-throughput molecular pathology AN - 20370883; 7656775 AB - The tissue microarray has enabled high-throughput pathology. Rather than the laborious review of individual slides and issues of assay reproducibility across large series of specimens, tissue microarrays allow the review of a single stain on a single slide containing tens to hundreds of samples. This is a paradigm shift in pathology, away from histomorphology and toward molecular characterization by immunohistochemistry. This platform allows large retrospective clinical studies of biomarkers for correlation with outcome and can equally well be applied toward high-throughput analysis of cell lines and xenografts. Tissue microarrays encourage novel approaches to assaying tissue with retained histomorphology and have enabled image analysis in pathology. The reduction of tissue to an analyte for high-throughput analysis has highlighted the importance of a high quality tissue and the impact of tissue handling and processing in the quality of data that can be obtained from analysis of tissue. JF - Current Opinion in Biotechnology AU - Takikita, Mikiko AU - Chung, Joon-Yong AU - Hewitt, Stephen M AD - Tissue Array Research Program, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, TARP Lab, MSC 4605, Bethesda, MD 20892-4605, USA, genejock@helix.nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 318 EP - 325 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 18 IS - 4 SN - 0958-1669, 0958-1669 KW - Biotechnology and Bioengineering Abstracts KW - Reviews KW - Image processing KW - Stains KW - Xenografts KW - biomarkers KW - Immunohistochemistry KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20370883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Biotechnology&rft.atitle=Tissue+microarrays+enabling+high-throughput+molecular+pathology&rft.au=Takikita%2C+Mikiko%3BChung%2C+Joon-Yong%3BHewitt%2C+Stephen+M&rft.aulast=Takikita&rft.aufirst=Mikiko&rft.date=2007-08-01&rft.volume=18&rft.issue=4&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Biotechnology&rft.issn=09581669&rft_id=info:doi/10.1016%2Fj.copbio.2007.05.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Reviews; Xenografts; Immunohistochemistry; Image processing; Stains; biomarkers DO - http://dx.doi.org/10.1016/j.copbio.2007.05.007 ER - TY - JOUR T1 - Cardiotoxicity of Ma Huang/Caffeine or Ephedrine/Caffeine in a Rodent Model System AN - 20367026; 7692085 AB - Ma Huang (equivalent to 0, 12.5, 25, or 50 mg/kg ephedrine) or ephedrine (0, 6.25, 12.5, 25 mg/kg) were administered as one bolus oral dose to male F344 rats with and without caffeine. The herbal medicine Ma Huang (ephedra) in combination with caffeine caused rapid clinical signs of toxicity including salivation, hyperactivity, ataxia, and eventually lethargy, and failure to respond to stimuli. When this syndrome of clinical signs emerged, animals were moribund sacrificed, and a histological analysis for heart lesions performed. Cardiotoxicity included hemorrhage, necrosis, and degeneration in the ventricles or interventricular septum within 2-4 hours after treatment with Ma Huang (ephedra)/caffeine or ephedrine (the principal active component in Ma Huang)/caffeine. There was a steep dose response curve for cardiotoxicity with minimal toxicity seen at levels of Ma Huang (equivalent to 12.5 mg/kg ephedrine) with caffeine. However, cardiotoxic lesions occurred in 28% of animals with Ma Huang dosages equivalent to 25 mg/kg ephedrine with 15 or 30 mg/kg caffeine, and in 90% of animals at Ma Huang exposures equivalent to 50 mg/kg ephedrine with 15 or 30 mg/kg caffeine. Cardiotoxic lesions occurred in 47% of animals in the 25 mg/kg ephedrine groups with caffeine at 7.25, 15, or 30 mg/kg. There was no statistical difference in the occurrence of cardiotoxic lesions when 15 or 30 mg/kg caffeine was combined with Ma Huang equivalent to 25 or 50 mg/kg ephedrine; likewise there was no statistical difference in the occurrence of cardiotoxic lesions when 7.25, 15, or 30 mg/kg caffeine was combined with 25 mg/kg ephedrine. These results show that the cardiotoxic effects of the herbal medicine, Ma Huang, are similar to that of ephedrine, the principal active ingredient in the herbal medicine. The combination of Ma Huang or ephedrine with caffeine enhanced the cardiotoxicity over that with the herbal medicine or the active ingredient alone. JF - Toxicologic Pathology AU - Dunnick, J K AU - Kissling, G AU - Gerken, D K AU - Vallant, M A AU - Nyska, A AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 657 EP - 664 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 35 IS - 5 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Heart KW - Statistics KW - Toxicity KW - Hemorrhage KW - Necrosis KW - Herbal medicines KW - Ataxia KW - Caffeine KW - Ephedrine KW - Degeneration KW - Septum KW - Hyperactivity KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20367026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Cardiotoxicity+of+Ma+Huang%2FCaffeine+or+Ephedrine%2FCaffeine+in+a+Rodent+Model+System&rft.au=Dunnick%2C+J+K%3BKissling%2C+G%3BGerken%2C+D+K%3BVallant%2C+M+A%3BNyska%2C+A&rft.aulast=Dunnick&rft.aufirst=J&rft.date=2007-08-01&rft.volume=35&rft.issue=5&rft.spage=657&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1080%2F01926230701459978 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Heart; Necrosis; Statistics; Ataxia; Herbal medicines; Degeneration; Ephedrine; Caffeine; Septum; Toxicity; Hemorrhage; Hyperactivity DO - http://dx.doi.org/10.1080/01926230701459978 ER - TY - JOUR T1 - Correlation between binding rate constants and individual information of E. coli Fis binding sites AN - 20332159; 7616143 AB - Individual protein binding sites on DNA can be measured in bits of information. This information is related to the free energy of binding by the second law of thermodynamics, but binding kinetics appear to be inaccessible from sequence information since the relative contributions of the on- and off-rates to the binding constant, and hence the free energy, are unknown. However, the on-rate could be independent of the sequence since a protein is likely to bind once it is near a site. To test this, we used surface plasmon resonance and electromobility shift assays to determine the kinetics for binding of the Fis protein to a range of naturally occurring binding sites. We observed that the logarithm of the off-rate is indeed proportional to the individual information of the binding sites, as predicted. However, the on-rate is also related to the information, but to a lesser degree. We suggest that the on-rate is mostly determined by DNA bending, which in turn is determined by the sequence information. Finally, we observed a break in the binding curve around zero bits of information. The break is expected from information theory because it represents the coding demarcation between specific and nonspecific binding. JF - Nucleic Acids Research AU - Shultzaberger, Ryan K AU - Roberts, Lindsey R AU - Lyakhov, Ilya G AU - Sidorov, Igor A AU - Stephen, Andrew G AU - Fisher, Robert J AU - Schneider, Thomas D AD - National Cancer Institute at Frederick, Center for Cancer Research Nanobiology Program, The Protein Chemistry Laboratory, Advanced Technology Program, SAIC - Frederick, NCI - Frederick Bldg. 469, Rm 237 Frederick, MD 21782 and Basic Research Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD 21702, USA Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 5275 EP - 5283 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 35 IS - 16 SN - 0305-1048, 0305-1048 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - surface plasmon resonance KW - Thermodynamics KW - Kinetics KW - Nucleotide sequence KW - FIS protein KW - Escherichia coli KW - DNA KW - Free energy KW - Information theory KW - J 02310:Genetics & Taxonomy KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20332159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Correlation+between+binding+rate+constants+and+individual+information+of+E.+coli+Fis+binding+sites&rft.au=Shultzaberger%2C+Ryan+K%3BRoberts%2C+Lindsey+R%3BLyakhov%2C+Ilya+G%3BSidorov%2C+Igor+A%3BStephen%2C+Andrew+G%3BFisher%2C+Robert+J%3BSchneider%2C+Thomas+D&rft.aulast=Shultzaberger&rft.aufirst=Ryan&rft.date=2007-08-01&rft.volume=35&rft.issue=16&rft.spage=5275&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - surface plasmon resonance; Thermodynamics; Nucleotide sequence; Kinetics; FIS protein; DNA; Information theory; Free energy; Escherichia coli ER - TY - JOUR T1 - Brain and whole-body imaging in nonhuman primates with [ super(11)C]MeS-IMPY, a candidate radioligand for beta -amyloid plaques AN - 20306104; 7599461 AB - [ super(11)C]MeS-IMPY ([S-methyl- super(11)C]N,N-dimethyl-4-(6-(methylthio) imidazo[1,2-a]pyridine-2-yl)aniline) is a potential radioligand for imaging beta -amyloid plaques with positron emission tomography (PET). The aims of this study were to evaluate [ super(11)C]MeS-IMPY uptake in nonhuman primate brain and to estimate radiation exposure from serial whole-body images. Eight PET studies were performed in rhesus monkeys to measure the brain uptake and washout of [ super(11)C]MeS-IMPY. Time-activity data were analyzed with one-tissue and two-tissue compartmental models using radiometabolite-corrected plasma input function. In addition, two whole-body PET scans were acquired for 120 min to determine the biodistribution of [ super(11)C]MeS-IMPY. Tomographic PET images were compressed into a single planar image to identify organs with the highest radiation exposures. Estimates of the absorbed dose of radiation were calculated using OLINDA 1.0. Injection of [ super(11)C]MeS-IMPY caused little change in pulse rate, blood pressure, respiratory rate and temperature. [ super(11)C]MeS-IMPY showed high standardized brain uptake values of similar to 500% and 600% between 2 and 3 min in cortical regions and the cerebellum, respectively. The brain uptake of [ super(11)C]MeS-IMPY was widespread and quite uniform across all cortical regions. Activity rapidly washed out of the brain, with 20% of peak activity remaining at 40 min. Thus, all brain regions showed minimal retention of radioactivity, consistent with these healthy young animals having negligible amyloid plaques. Regional brain activity fitted well into a one-tissue compartment model. The average volume of distribution in all brain regions was 7.66 plus or minus 2.14 ml/cm super(3) (n=4). The organs with the highest radiation exposure ( mu Sv/MBq) were the gallbladder Wall (33.4), urinary bladder (17) and lungs (12.9), with a resulting effective dose of 4.9 mu Sv/MBq (18 mrem/mCi). The high brain uptake, rapid washout and quantifiable volume of distribution in nonhuman primate brain further support the evaluation of [ super(11)C]MeS-IMPY. Calculated dosimetry results are comparable with those for other super(11)C-labeled brain imaging radioligands. JF - Nuclear Medicine and Biology AU - Seneca, N AU - Cai, L AU - Liow, J-S AU - Zoghbi, S S AU - Gladding, R L AU - Hong, J AU - Pike, V W AU - Innis, R B AD - Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-2035, USA, nicholasseneca@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 681 EP - 689 VL - 34 IS - 6 SN - 0969-8051, 0969-8051 KW - Rhesus macaque KW - Rhesus monkey KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Neuroimaging KW - Data processing KW - Urinary bladder KW - Dosimetry KW - Alzheimer's disease KW - Brain KW - Cerebellum KW - Primates KW - Blood pressure KW - Gallbladder KW - Cortex KW - Radiation KW - Lung KW - Positron emission tomography KW - Macaca mulatta KW - Plaques KW - Radioactivity KW - beta -Amyloid KW - W 30910:Imaging KW - N3 11006:Neuroanatomy, histology & cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20306104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+Medicine+and+Biology&rft.atitle=Brain+and+whole-body+imaging+in+nonhuman+primates+with+%5B+super%2811%29C%5DMeS-IMPY%2C+a+candidate+radioligand+for+beta+-amyloid+plaques&rft.au=Seneca%2C+N%3BCai%2C+L%3BLiow%2C+J-S%3BZoghbi%2C+S+S%3BGladding%2C+R+L%3BHong%2C+J%3BPike%2C+V+W%3BInnis%2C+R+B&rft.aulast=Seneca&rft.aufirst=N&rft.date=2007-08-01&rft.volume=34&rft.issue=6&rft.spage=681&rft.isbn=&rft.btitle=&rft.title=Nuclear+Medicine+and+Biology&rft.issn=09698051&rft_id=info:doi/10.1016%2Fj.nucmedbio.2007.06.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Temperature effects; Neuroimaging; Data processing; Urinary bladder; Alzheimer's disease; Dosimetry; Cerebellum; Brain; Blood pressure; Gallbladder; Cortex; Radiation; Lung; Positron emission tomography; Plaques; beta -Amyloid; Radioactivity; Macaca mulatta; Primates DO - http://dx.doi.org/10.1016/j.nucmedbio.2007.06.002 ER - TY - JOUR T1 - Development of Smallpox Vaccine Candidates with Integrated Interleukin-15 That Demonstrate Superior Immunogenicity, Efficacy, and Safety in Mice AN - 20303101; 7532317 AB - The potential use of variola virus, the etiological agent of smallpox, as a bioterror agent has heightened the interest in the reinitiation of smallpox vaccination. However, the currently licensed Dryvax vaccine, despite its documented efficacy in eradicating smallpox, is not optimal for the vaccination of contemporary populations with large numbers of individuals with immunodeficiencies because of severe adverse effects that can occur in such individuals. Therefore, the development of safer smallpox vaccines that can match the immunogenicity and efficacy of Dryvax for the vaccination of contemporary populations remains a priority. Using the Wyeth strain of vaccinia virus derived from the Dryvax vaccine, we generated a recombinant Wyeth interleukin-15 (IL-15) with integrated IL-15, a cytokine with potent immunostimulatory functions. The integration of IL-15 into the Wyeth strain resulted in a >1,000-fold reduction in lethality of vaccinated athymic nude mice and induced severalfold-higher cellular and humoral immune responses in wild-type mice that persisted longer than those induced by the parental Wyeth strain. The superior efficacy of Wyeth IL-15 was further demonstrated by the ability of vaccinated mice to fully survive a lethal intranasal challenge of virulent vaccinia virus even 10 months after vaccination, whereas all mice vaccinated with parental Wyeth strain succumbed. By integrating IL-15 into modified vaccinia virus Ankara (MVA), a virus currently under consideration as a substitute for the Dryvax vaccine, we developed a second vaccine candidate (MVA IL-15) with greater immunogenicity and efficacy than Dryvax. Thus, Wyeth IL-15 and MVA IL-15 viruses hold promise as more-efficacious and safe alternatives to the Dryvax vaccine. JF - Journal of Virology AU - Perera, Liyanage P AU - Waldmann, Thomas A AU - Mosca, Joseph D AU - Baldwin, Nicole AU - Berzofsky, Jay A AU - Oh, Sang-Kon AD - Metabolism Branch. Vaccine Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-1374. JDM Technologies Inc., Ellicott City, Maryland 21042. Baylor Institute for Immunology Research, Baylor University Medical Center at Dallas, 3434 Live Oak Street, Dallas, Texas 75204 Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 8774 EP - 8783 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 81 IS - 16 SN - 0022-538X, 0022-538X KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Immunodeficiency KW - Integration KW - Interleukin 15 KW - Variola virus KW - Smallpox KW - Lethality KW - Vaccinia virus KW - Immunogenicity KW - Vaccines KW - Side effects KW - V 22350:Immunology KW - W 30915:Pharmaceuticals & Vaccines KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20303101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Development+of+Smallpox+Vaccine+Candidates+with+Integrated+Interleukin-15+That+Demonstrate+Superior+Immunogenicity%2C+Efficacy%2C+and+Safety+in+Mice&rft.au=Perera%2C+Liyanage+P%3BWaldmann%2C+Thomas+A%3BMosca%2C+Joseph+D%3BBaldwin%2C+Nicole%3BBerzofsky%2C+Jay+A%3BOh%2C+Sang-Kon&rft.aulast=Perera&rft.aufirst=Liyanage&rft.date=2007-08-01&rft.volume=81&rft.issue=16&rft.spage=8774&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Vaccinia virus; Variola virus; Interleukin 15; Vaccines; Smallpox; Immunogenicity; Integration; Side effects; Lethality; Immunodeficiency ER - TY - JOUR T1 - Recombinant human parainfluenza virus type 2 vaccine candidates containing a 3' genomic promoter mutation and L polymerase mutations are attenuated and protective in non-human primates AN - 20302787; 7640983 AB - Previously, we identified several attenuating mutations in the L polymerase protein of human parainfluenza virus type 2 (HPIV2) and genetically stabilized those mutations using reverse genetics [Nolan SM, Surman S, Amaro-Carambot E, Collins PL, Murphy BR, Skiadopoulos MH. Live-attenuated intranasal parainfluenza virus type 2 vaccine candidates developed by reverse genetics containing L polymerase protein mutations imported from heterologous paramyxoviruses. Vaccine 2005; 39(23):4765-74]. Here we describe the discovery of an attenuating mutation at nucleotide 15 (15T->C) in the 3' genomic promoter that was also present in the previously characterized mutants. We evaluated the properties of this promoter mutation alone and in various combinations with the L polymerase mutations. Amino acid substitutions at L protein positions 460 (460A or 460P) or 948 (948L), or deletion of amino acids 1724 and 1725 ( Delta 1724), each conferred a temperature sensitivity (ts) phenotype whereas the 15T->C mutation did not. The 460A and 948L mutations each contributed to restricted replication in the lower respiratory tract of African green monkeys, but the Delta 1724 mutation increased attenuation only in certain combinations with other mutations. We constructed two highly attenuated viruses, rV94(15C)/460A/948L and rV94(15C)/948L/ Delta 1724, that were immunogenic and protective against challenge with wild-type HPIV2 in African green monkeys and, therefore, appear to be suitable for evaluation in humans. JF - Vaccine AU - Nolan, Sheila M AU - Skiadopoulos, Mario H AU - Bradley, Konrad AU - Kim, Olivia S AU - Bier, Stacia AU - Amaro-Carambot, Emerito AU - Surman, Sonja R AU - Davis, Stephanie AU - Claire, Marisa St AU - Elkins, Randy AU - Collins, Peter L AU - Murphy, Brian R AU - Schaap-Nutt, Anne AD - Laboratory of Infectious Diseases, Respiratory Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA, schaapa@niaid.nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 6409 EP - 6422 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 25 IS - 34 SN - 0264-410X, 0264-410X KW - Primates KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Human parainfluenza virus KW - Live attenuated vaccine candidates KW - Non-human primate study KW - Temperature effects KW - double prime L protein KW - Amino acid substitution KW - Replication KW - Nucleotides KW - Parainfluenza virus KW - Parainfluenza KW - Promoters KW - Gene deletion KW - Immunogenicity KW - genomics KW - Vaccines KW - Mutation KW - Respiratory tract KW - V 22350:Immunology KW - F 06905:Vaccines KW - W 30915:Pharmaceuticals & Vaccines KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20302787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Recombinant+human+parainfluenza+virus+type+2+vaccine+candidates+containing+a+3%27+genomic+promoter+mutation+and+L+polymerase+mutations+are+attenuated+and+protective+in+non-human+primates&rft.au=Nolan%2C+Sheila+M%3BSkiadopoulos%2C+Mario+H%3BBradley%2C+Konrad%3BKim%2C+Olivia+S%3BBier%2C+Stacia%3BAmaro-Carambot%2C+Emerito%3BSurman%2C+Sonja+R%3BDavis%2C+Stephanie%3BClaire%2C+Marisa+St%3BElkins%2C+Randy%3BCollins%2C+Peter+L%3BMurphy%2C+Brian+R%3BSchaap-Nutt%2C+Anne&rft.aulast=Nolan&rft.aufirst=Sheila&rft.date=2007-08-01&rft.volume=25&rft.issue=34&rft.spage=6409&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2007.06.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Temperature effects; double prime L protein; Amino acid substitution; Replication; Nucleotides; Parainfluenza; Promoters; Gene deletion; Immunogenicity; Vaccines; genomics; Mutation; Respiratory tract; Primates; Parainfluenza virus DO - http://dx.doi.org/10.1016/j.vaccine.2007.06.028 ER - TY - JOUR T1 - The Large Clostridial Toxins from Clostridium sordellii and C. difficile Repress Glucocorticoid Receptor Activity AN - 20297720; 7530484 AB - We have previously shown that Bacillus anthracis lethal toxin represses glucocorticoid receptor (GR) transactivation. We now report that repression of GR activity also occurs with the large clostridial toxins produced by Clostridium sordellii and C. difficile. This was demonstrated using a transient transfection assay system for GR transactivation. We also report that C. sordellii lethal toxin inhibited GR function in an ex vivo assay, where toxin reduced the dexamethasone suppression of the proinflammatory cytokine tumor necrosis factor alpha (TNF- alpha ). Furthermore, the glucocorticoid antagonist RU-486 in combination with C. sordellii lethal toxin additively prevented glucocorticoid suppression of TNF- alpha . These findings corroborate the fact that GR is a target for the toxin and suggest a physiological role for toxin-associated GR repression in inflammation. Finally, we show that this repression is associated with toxins that inactivate p38 mitogen-activated protein kinase (MAPK). JF - Infection and Immunity AU - Tait, ASasha AU - Dalton, Monique AU - Geny, Blandine AU - D'Agnillo, Felice AU - Popoff, Michel R AU - Sternberg, Esther M AD - Section on Neuroendocrine Immunology and Behavior, National Institute of Mental Health, NIH, Rockville, Maryland. Unite des Bacteries Anaerobes et Toxines, Institut Pasteur, Paris, France. Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 3935 EP - 3940 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 8 SN - 0019-9567, 0019-9567 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Dexamethasone KW - MAP kinase KW - Glucocorticoid receptors KW - Clostridium sordellii KW - Transfection KW - Cytokines KW - Tumor necrosis factor- alpha KW - Bacillus anthracis KW - Glucocorticoids KW - Toxins KW - Inflammation KW - X 24370:Natural Toxins KW - J 02330:Biochemistry KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20297720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=The+Large+Clostridial+Toxins+from+Clostridium+sordellii+and+C.+difficile+Repress+Glucocorticoid+Receptor+Activity&rft.au=Tait%2C+ASasha%3BDalton%2C+Monique%3BGeny%2C+Blandine%3BD%27Agnillo%2C+Felice%3BPopoff%2C+Michel+R%3BSternberg%2C+Esther+M&rft.aulast=Tait&rft.aufirst=ASasha&rft.date=2007-08-01&rft.volume=75&rft.issue=8&rft.spage=3935&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Dexamethasone; MAP kinase; Glucocorticoid receptors; Transfection; Cytokines; Tumor necrosis factor- alpha; Glucocorticoids; Toxins; Inflammation; Clostridium sordellii; Bacillus anthracis ER - TY - JOUR T1 - Caffeine analogs: biomedical impact AN - 20275949; 7606618 AB - Caffeine, widely consumed in beverages, and many xanthine analogs have had a major impact on biomedical research. Caffeine and various analogs, the latter designed to enhance potency and selectivity toward specific biological targets, have played key roles in defining the nature and role of adenosine receptors, phosphodiesterases, and calcium release channels in physiological processes. Such xanthines and other caffeine-inspired heterocycles now provide important research tools and potential therapeutic agents for intervention in Alzheimer's disease, asthma, cancer, diabetes, and Parkinson's disease. Such compounds also have activity as analgesics, antiin-flammatories, antitussives, behavioral stimulants, diu-retics/natriuretics, and lipolytics. Adverse effects can include anxiety, hypertension, certain drug interactions, and withdrawal symptoms. JF - Cellular and Molecular Life Sciences AU - Daly, J W AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland 20892-0820 (USA), jdaly@nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 2153 EP - 2169 VL - 64 IS - 16 SN - 1420-682X, 1420-682X KW - Toxicology Abstracts KW - Drug interaction KW - Beverages KW - Anxiety KW - Adenosine receptors KW - Xanthine KW - Parkinson's disease KW - Alzheimer's disease KW - Asthma KW - Stimulants KW - Cancer KW - Diabetes mellitus KW - Neurodegenerative diseases KW - Calcium release channels KW - Movement disorders KW - Caffeine KW - Analgesics KW - phosphodiesterase KW - Side effects KW - Hypertension KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20275949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+and+Molecular+Life+Sciences&rft.atitle=Caffeine+analogs%3A+biomedical+impact&rft.au=Daly%2C+J+W&rft.aulast=Daly&rft.aufirst=J&rft.date=2007-08-01&rft.volume=64&rft.issue=16&rft.spage=2153&rft.isbn=&rft.btitle=&rft.title=Cellular+and+Molecular+Life+Sciences&rft.issn=1420682X&rft_id=info:doi/10.1007%2Fs00018-007-7051-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Drug interaction; Beverages; Anxiety; Adenosine receptors; Parkinson's disease; Xanthine; Alzheimer's disease; Asthma; Stimulants; Cancer; Diabetes mellitus; Neurodegenerative diseases; Movement disorders; Calcium release channels; Caffeine; Analgesics; Side effects; phosphodiesterase; Hypertension DO - http://dx.doi.org/10.1007/s00018-007-7051-9 ER - TY - JOUR T1 - Prions of fungi: inherited structures and biological roles AN - 20204193; 7565508 AB - The term 'prion' means an infectious protein that does not need an accompanying nucleic acid. There are six fungal prions, including four self- propagating amyloids and two enzymes that are necessary to activate their inactive precursors. Here we explore the scope of the prion phenomenon, the biological and evolutionary roles of prions, the structural basis of the amyloid prions and the prominent role of chaperones (proteins that affect the folding of other proteins) and other cellular components in prion generation and propagation. JF - Nature Reviews: Microbiology AU - Wickner, Reed B AU - Edskes, Herman K AU - Shewmaker, Frank AU - Nakayashiki, Toru AD - Laboratory of Biochemistry and Genetics, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0830, USA., wickner@helix.nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 611 EP - 618 PB - Nature Publishing Co., 345 Park Ave. S. 10th Floor New York NY 10010-1707 USA, [mailto:nature@natureny.com], [URL:http://www.nature.com/nature/] VL - 5 IS - 8 SN - 1740-1526, 1740-1526 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - nucleic acids KW - Protein folding KW - Fungi KW - Prion protein KW - Enzymes KW - Chaperones KW - beta -Amyloid KW - Evolution KW - Amyloid KW - A 01490:Miscellaneous KW - K 03310:Genetics & Taxonomy KW - V 22380:Prions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20204193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Microbiology&rft.atitle=Prions+of+fungi%3A+inherited+structures+and+biological+roles&rft.au=Wickner%2C+Reed+B%3BEdskes%2C+Herman+K%3BShewmaker%2C+Frank%3BNakayashiki%2C+Toru&rft.aulast=Wickner&rft.aufirst=Reed&rft.date=2007-08-01&rft.volume=5&rft.issue=8&rft.spage=611&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Microbiology&rft.issn=17401526&rft_id=info:doi/10.1038%2Fnrmicro1708 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - nucleic acids; Protein folding; Fungi; Prion protein; Enzymes; Chaperones; beta -Amyloid; Evolution; Amyloid DO - http://dx.doi.org/10.1038/nrmicro1708 ER - TY - JOUR T1 - Farnesol-Induced Apoptosis in Human Lung Carcinoma Cells Is Coupled to the Endoplasmic Reticulum Stress Response AN - 20136393; 7555797 AB - Farnesol (FOH) and other isoprenoid alcohols induce apoptosis in various carcinoma cells and inhibit tumorigenesis in several in vivo models. However, the mechanisms by which they mediate their effects are not yet fully understood. In this study, we show that FOH is an effective inducer of apoptosis in several lung carcinoma cells, including H460. This induction is associated with activation of several caspases and cleavage of poly(ADP-ribose) polymerase (PARP). To obtain insight into the mechanism involved in FOH-induced apoptosis, we compared the gene expression profiles of FOH-treated and control H460 cells by microarray analysis. This analysis revealed that many genes implicated in endoplasmic reticulum (ER) stress signaling, including ATF3, DDIT3, HERPUD1, HSPA5, XBP1, PDIA4, and PHLDA1, were highly up-regulated within 4 h of FOH treatment, suggesting that FOH-induced apoptosis involves an ER stress response. This was supported by observations showing that treatment with FOH induces splicing of XBP1 mRNA and phosphorylation of eIF2 alpha . FOH induces activation of several mitogen-activated protein kinase (MAPK) pathways, including p38, MAPK/extracellular signal-regulated kinase (ERK) kinase (MEK)-ERK, and c-jun NH sub(2)-terminal kinase (JNK). Inhibition of MEK1/2 by U0126 inhibited the induction of ER stress response genes. In addition, knockdown of the MEK1/2 and JNK1/2 expression by short interfering RNA (siRNA) effectively inhibited the cleavage of caspase-3 and PARP and apoptosis induced by FOH. However, only MEK1/2 siRNAs inhibited the induction of ER stress-related genes, XBP1 mRNA splicing, and eIF2 alpha phosphorylation. Our results show that FOH-induced apoptosis is coupled to ER stress and that activation of MEK1/2 is an early upstream event in the FOH-induced ER stress signaling cascade. [Cancer Res 2007; 67(16):7929-36] JF - Cancer Research AU - Joo, Joung Hyuck AU - Liao, Grace AU - Collins, Jennifer B AU - Grissom, Sherry F AU - Jetten, Anton M AD - Cell Biology Section, LRB, and Microarray Group, Division of Intramural Research, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 7929 EP - 7936 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 67 IS - 16 SN - 0008-5472, 0008-5472 KW - Biotechnology and Bioengineering Abstracts KW - Terpenes KW - MAP kinase KW - c-Jun amino-terminal kinase KW - Apoptosis KW - Lung carcinoma KW - GRP78 protein KW - Tumorigenesis KW - Stress KW - Farnesol KW - Carcinoma KW - Gene expression KW - Extracellular signal-regulated kinase KW - Endoplasmic reticulum KW - Splicing KW - Phosphorylation KW - siRNA KW - Poly(ADP-ribose) polymerase KW - Activating transcription factor 3 KW - Caspase-3 KW - alcohols KW - Initiation factor eIF-2 KW - Signal transduction KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20136393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Farnesol-Induced+Apoptosis+in+Human+Lung+Carcinoma+Cells+Is+Coupled+to+the+Endoplasmic+Reticulum+Stress+Response&rft.au=Joo%2C+Joung+Hyuck%3BLiao%2C+Grace%3BCollins%2C+Jennifer+B%3BGrissom%2C+Sherry+F%3BJetten%2C+Anton+M&rft.aulast=Joo&rft.aufirst=Joung&rft.date=2007-08-01&rft.volume=67&rft.issue=16&rft.spage=7929&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Terpenes; MAP kinase; Apoptosis; c-Jun amino-terminal kinase; Lung carcinoma; GRP78 protein; Tumorigenesis; Stress; Farnesol; Carcinoma; Gene expression; Endoplasmic reticulum; Extracellular signal-regulated kinase; Splicing; siRNA; Phosphorylation; Poly(ADP-ribose) polymerase; Activating transcription factor 3; alcohols; Caspase-3; Initiation factor eIF-2; Signal transduction ER - TY - JOUR T1 - Anticancer medicines in development: assessment of bioactivity profiles within the National Cancer Institute anticancer screening data AN - 20129471; 7559638 AB - We present an analysis of current anticancer compounds that are in phase I, II, or III clinical trials and their structural analogues that have been screened in the National Cancer Institute (NCI) anticancer screening program. Bioactivity profiles, measured across the NCI 60 cell lines, were examined for a correspondence between the type of cancer proposed for clinical testing and selective sensitivity to appropriately matched tumor subpanels in the NCI screen. These results find strongest support for using the NCI anticancer screen to select analogue compounds with selective sensitivity to the leukemia, colon, central nervous system, melanoma, and ovarian panels, but not for renal, prostate, and breast panels. These results are extended to applications of two-dimensional structural features to further refine compound selections based on tumor panel sensitivity obtained from tumor screening results. [Mol Cancer Ther 2007; 6(8):2261-70] JF - Molecular Cancer Therapeutics AU - Covell, David G AU - Huang, Ruili AU - Wallqvist, Anders AD - National Cancer Institute-Frederick, Developmental Therapeutics Program, Screening Technologies Branch, Laboratory of Computational Technologies and Laboratory of Computational Technologies, Science Applications International Corporation-Frederick, Inc., National Cancer Institute-Frederick, Frederick, Maryland Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 2261 EP - 2270 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 6 IS - 8 SN - 1535-7163, 1535-7163 KW - Biotechnology and Bioengineering Abstracts KW - Central nervous system KW - Leukemia KW - Data processing KW - Colon KW - Kidney KW - Tumors KW - Clinical trials KW - Prostate KW - Cancer KW - Melanoma KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20129471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cancer+Therapeutics&rft.atitle=Anticancer+medicines+in+development%3A+assessment+of+bioactivity+profiles+within+the+National+Cancer+Institute+anticancer+screening+data&rft.au=Covell%2C+David+G%3BHuang%2C+Ruili%3BWallqvist%2C+Anders&rft.aulast=Covell&rft.aufirst=David&rft.date=2007-08-01&rft.volume=6&rft.issue=8&rft.spage=2261&rft.isbn=&rft.btitle=&rft.title=Molecular+Cancer+Therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Leukemia; Central nervous system; Data processing; Colon; Kidney; Tumors; Prostate; Clinical trials; Cancer; Melanoma ER - TY - JOUR T1 - TREK-1: A potential target for novel antidepressants AN - 20107017; 7630643 AB - The neurotransmitter serotonin (5-HT: 5-hydroxytryptamin) was suggested to be involved in the pathogenesis of depression as well as in the mechanisms of antidepressant treatments. However, the molecular mechanisms underlying the pathophysiology or treatment of depression are still poorly understood. A recent paper has shown that deletion of the two-pore domain potassium channel TREK-1 results in an antidepressant-like phenotype. TREK-1-deficient mice behave as if they have been treated with an antidepressant drug, such as fluoxetine. Moreover, TREK-1-deficient mice showed a reduced elevation of corticosterone level under stress, an increased efficacy of 5-HT neurotransmission and an increased fluoxetine-induced neurogenesis in the hippocampus. Selective serotonin reuptake inhibitors (SSRIs) inhibited not only the 5-HT transporter but also the TREK-1 channel. In this article, we review the molecular and functional properties of the TREK-1 channel, which is a potential target for novel antidepressants. JF - Japanese Journal of Neuropsychopharmacology AU - Maruyama, Y AU - Yamada, M AD - Department of Psychogeriatrics, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-machi, Kodaira, 187-8553 Japan, ymaru@ncnp.go.jp Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 147 EP - 151 VL - 27 IS - 4 SN - 1340-2544, 1340-2544 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Molecular modelling KW - Depression KW - Hippocampus KW - Stress KW - Serotonin uptake inhibitors KW - Serotonin KW - Fluoxetine KW - Corticosterone KW - Antidepressants KW - Neurogenesis KW - Neurotransmission KW - Reviews KW - Neurotransmitters KW - Potassium channels KW - Drugs KW - N3 11001:Behavioral and Cognitive Neuroscience KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20107017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Japanese+Journal+of+Neuropsychopharmacology&rft.atitle=TREK-1%3A+A+potential+target+for+novel+antidepressants&rft.au=Maruyama%2C+Y%3BYamada%2C+M&rft.aulast=Maruyama&rft.aufirst=Y&rft.date=2007-08-01&rft.volume=27&rft.issue=4&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Japanese+Journal+of+Neuropsychopharmacology&rft.issn=13402544&rft_id=info:doi/ LA - Japanese DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Depression; Hippocampus; Serotonin uptake inhibitors; Stress; Serotonin; Fluoxetine; Antidepressants; Corticosterone; Neurogenesis; Neurotransmission; Reviews; Neurotransmitters; Potassium channels; Drugs ER - TY - JOUR T1 - Chronic lithium administration attenuates up-regulated brain arachidonic acid metabolism in a rat model of neuroinflammation AN - 20095321; 7907571 AB - Neuroinflammation, caused by a 6-day intracerebroventricular infusion of lipopolysaccharide (LPS) in rats, is associated with the up-regulation of brain arachidonic acid (AA) metabolism markers. Because chronic LiCl down-regulates markers of brain AA metabolism, we hypothesized that it would attenuate increments of these markers in LPS-infused rats. Incorporation coefficients k* of AA from plasma into brain, and other brain AA metabolic markers, were measured in rats that had been fed a LiCl or control diet for 6 weeks, and subjected in the last 6 days on the diet to intracerebroventricular infusion of artificial CSF or of LPS. In rats on the control diet, LPS compared with CSF infusion increased k* significantly in 28 regions, whereas the LiCl diet prevented k* increments in 18 of these regions. LiCl in CSF infused rats increased k* in 14 regions, largely belonging to auditory and visual systems. Brain cytoplasmic phospholipase A sub(2) activity, and prostaglandin E sub(2) and thromboxane B sub(2) concentrations, were increased significantly by LPS infusion in rats fed the control but not the LiCl diet. Chronic LiCl administration attenuates LPS-induced up-regulation of a number of brain AA metabolism markers. To the extent that this up-regulation has neuropathological consequences, lithium might be considered for treating human brain diseases accompanied by neuroinflammation. JF - Journal of Neurochemistry AU - Basselin, Mireille AU - Villacreses, Nelly E AU - Lee, Ho-Joo AU - Bell, Jane M AU - Rapoport, Stanley I AD - Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA, mirvasln@mail.nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 761 EP - 772 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 102 IS - 3 SN - 0022-3042, 0022-3042 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - arachidonic acid KW - lipopolysaccharide KW - lithium KW - neuroinflammation KW - neuroprotection KW - phospholipase A sub(2) KW - Diets KW - Thromboxanes KW - Phospholipase A2 KW - Animal models KW - Visual system KW - Lithium chloride KW - Brain KW - Arachidonic acid KW - Prostaglandin E2 KW - Inflammation KW - Cerebrospinal fluid KW - Lipopolysaccharides KW - Lithium KW - Metabolism KW - N3 11008:Neurochemistry KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20095321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurochemistry&rft.atitle=Chronic+lithium+administration+attenuates+up-regulated+brain+arachidonic+acid+metabolism+in+a+rat+model+of+neuroinflammation&rft.au=Basselin%2C+Mireille%3BVillacreses%2C+Nelly+E%3BLee%2C+Ho-Joo%3BBell%2C+Jane+M%3BRapoport%2C+Stanley+I&rft.aulast=Basselin&rft.aufirst=Mireille&rft.date=2007-08-01&rft.volume=102&rft.issue=3&rft.spage=761&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurochemistry&rft.issn=00223042&rft_id=info:doi/10.1111%2Fj.1471-4159.2007.04593.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Diets; Thromboxanes; Phospholipase A2; Brain; Lithium chloride; Visual system; Animal models; Arachidonic acid; Prostaglandin E2; Inflammation; Cerebrospinal fluid; Lipopolysaccharides; Metabolism; Lithium DO - http://dx.doi.org/10.1111/j.1471-4159.2007.04593.x ER - TY - JOUR T1 - Dose-response transition from cell cycle arrest to apoptosis with selective degradation of Mdm2 and p21 super(WAF1/CIP1) in response to the novel anticancer agent, aminoflavone (NSC 686288) AN - 20093998; 7491300 AB - Aminoflavone (AF, NSC 686288) is beginning clinical trials. It induces replication-mediated histone H2AX phosphorylation, DNA-protein crosslinks and activates p53. Here, we studied p21 super(CIP1/WAF1) and Mdm2 responses to AF. Although p53 stabilization and phosphorylation at serine 15 increased with dose and time of exposure, Mdm2 and p21 super(CIP1/WAF1) protein levels displayed a biphasic response, as they accumulated at submicromolar doses and then decreased with increasing AF. As both Mdm2 and p21 super(CIP1/WAF1) mRNA levels increased with AF concentration without reduction at higher concentrations, we measured the half-lives of Mdm2 and p21 super(CIP1/WAF1) proteins. Mdm2 and p21 super(CIP1/WAF1) half-lives were shortened with increasing AF concentrations. Proteasomal degradation appears responsible for the decrease of both Mdm2 and p21 super(CIP1/WAF1), as MG-132 prevented their degradation and revealed AF- induced Mdm2 polyubiquitylation. AF also induced protein kinase B (Akt) activation, which was reduced with increasing AF concentrations. Suppression of Akt by small interfering RNA was associated with downregulation of Mdm2 and p21 super(CIP1/WAF1) and with enhanced apoptosis. These results suggest that the cellular responses to AF are determined at least in part by Mdm2 and p21 super(CIP1/WAF1) protein levels, as well as by Akt activity, leading either to cell cycle arrest when Mdm2 and p21 super(CIP1/WAF1) are elevated, or to apoptosis when Mdm2 and p21 super(CIP1/WAF1) are degraded by the proteasome and Akt insufficiently activated to protect against apoptosis. JF - Oncogene AU - Meng, L-H AU - Kohn, K W AU - Pommier, Y AD - Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, pommier@nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 4806 EP - 4816 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 26 IS - 33 SN - 0950-9232, 0950-9232 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Oncogenes & Growth Factors Abstracts KW - p53 KW - proteasome KW - Akt KW - apoptosis KW - histone H2AX KW - DNA damage AF KW - aminoflavone KW - CHX KW - cycloheximide KW - siRNA KW - small interfering RNA KW - MDM2 protein KW - Apoptosis KW - Cell cycle KW - proteasomes KW - Clinical trials KW - Antitumor agents KW - mRNA KW - p53 protein KW - Phosphorylation KW - cyclin-dependent kinase inhibitor p21 KW - AKT protein KW - Cyclin-dependent kinase inhibitor p21 KW - Histone H2A KW - Serine KW - B 26670:Tumor Suppressors KW - W 30915:Pharmaceuticals & Vaccines KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20093998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Dose-response+transition+from+cell+cycle+arrest+to+apoptosis+with+selective+degradation+of+Mdm2+and+p21+super%28WAF1%2FCIP1%29+in+response+to+the+novel+anticancer+agent%2C+aminoflavone+%28NSC+686288%29&rft.au=Meng%2C+L-H%3BKohn%2C+K+W%3BPommier%2C+Y&rft.aulast=Meng&rft.aufirst=L-H&rft.date=2007-08-01&rft.volume=26&rft.issue=33&rft.spage=4806&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/10.1038%2Fsj.onc.1210283 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - MDM2 protein; Apoptosis; Cell cycle; proteasomes; Antitumor agents; Clinical trials; p53 protein; mRNA; cyclin-dependent kinase inhibitor p21; Phosphorylation; siRNA; AKT protein; Cyclin-dependent kinase inhibitor p21; Histone H2A; Serine DO - http://dx.doi.org/10.1038/sj.onc.1210283 ER - TY - JOUR T1 - Development and Validation of DNA Microarray for Genotyping Group A Rotavirus VP4 (P[4], P[6], P[8], P[9], and P[14]) and VP7 (G1 to G6, G8 to G10, and G12) Genes AN - 20091633; 7558216 AB - Previously, we reported the development of a microarray-based method for the identification of five clinically relevant G genotypes (G1 to G4 and G9) (V. Chizhikov et al., J. Clin. Microbiol. 40:2398-2407, 2002). The expanded version of the rotavirus microarray assay presented herein is capable of identifying (i) five clinically relevant human rotavirus VP4 genotypes (P[4], P[6], P[8], P[9], and P[14]) and (ii) five additional human rotavirus VP7 genotypes (G5, G6, G8, G10, and G12) on one chip. Initially, a total of 80 cell culture-adapted human and animal reference rotavirus strains of known P (P[1] to P[12], P[14], P[16], and P[20]) and G (G1-6, G8 to G12, and G14) genotypes isolated in various parts of the world were employed to evaluate the new microarray assay. All rotavirus strains bearing P[4], P[6], P[8], P[9], or P[14] and/or G1 to G6, G8 to G10, or G12 specificity were identified correctly. In addition, cross-reactivity to viruses of genotype G11, G13, or G14 or P[1] to P[3], P[5], P[7], P[10] to P[12], P[16], or P[20] was not observed. Next, we analyzed a total of 128 rotavirus-positive human stool samples collected in three countries (Brazil, Ghana, and the United States) by this assay and validated its usefulness. The results of this study showed that the assay was sensitive and specific and capable of unambiguously discriminating mixed rotavirus infections from nonspecific cross-reactivity; the inability to discriminate mixed infections from nonspecific cross-reactivity is one of the inherent shortcomings of traditional multiplex reverse transcription-PCR genotyping. Moreover, because the hybridization patterns exhibited by rotavirus strains of different genotypes can vary, this method may be ideal for analyzing the genetic polymorphisms of the VP7 or VP4 genes of rotaviruses. JF - Journal of Clinical Microbiology AU - Honma, Shinjiro AU - Chizhikov, Vladimir AU - Santos, Norma AU - Tatsumi, Masatoshi AU - do Carmo S. T. Timenetsky, Maria AU - Linhares, Alexandre C AU - Mascarenhas, Joana D'Arc P AU - Ushijima, Hiroshi AU - Armah, George E AU - Gentsch, Jon R AU - Hoshino, Yasutaka AD - Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland. Laboratory of Method Development, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland. Instituto de Microbiologia, Universidade Federal do Rio de Janeiro, Rio de Janerio, Brazil. Instituto Adolfo Lutz, Sao Paulo, Brazil. Instituto Evandro Chagas, Secretaria de Vigilancia em Saude, Belem, Brazil. University of Tokyo, Tokyo, Japan. University of Ghana, Legon, Ghana. Gastroenteritis and Respiratory Viruses Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, Georgia Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 2641 EP - 2648 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 45 IS - 8 SN - 0095-1137, 0095-1137 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts KW - Rotavirus KW - Cross-reactivity KW - Human rotavirus KW - Genotyping KW - Gene polymorphism KW - Genotypes KW - Feces KW - Group a rotavirus KW - DNA microarrays KW - Mixed infection KW - W 30910:Imaging KW - V 22300:Methods KW - G 07730:Development & Cell Cycle KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20091633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Development+and+Validation+of+DNA+Microarray+for+Genotyping+Group+A+Rotavirus+VP4+%28P%5B4%5D%2C+P%5B6%5D%2C+P%5B8%5D%2C+P%5B9%5D%2C+and+P%5B14%5D%29+and+VP7+%28G1+to+G6%2C+G8+to+G10%2C+and+G12%29+Genes&rft.au=Honma%2C+Shinjiro%3BChizhikov%2C+Vladimir%3BSantos%2C+Norma%3BTatsumi%2C+Masatoshi%3Bdo+Carmo+S.+T.+Timenetsky%2C+Maria%3BLinhares%2C+Alexandre+C%3BMascarenhas%2C+Joana+D%27Arc+P%3BUshijima%2C+Hiroshi%3BArmah%2C+George+E%3BGentsch%2C+Jon+R%3BHoshino%2C+Yasutaka&rft.aulast=Honma&rft.aufirst=Shinjiro&rft.date=2007-08-01&rft.volume=45&rft.issue=8&rft.spage=2641&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cross-reactivity; Gene polymorphism; Genotyping; Genotypes; Feces; DNA microarrays; Mixed infection; Rotavirus; Human rotavirus; Group a rotavirus ER - TY - JOUR T1 - Proteomic analysis of serum, plasma, and lymph for the identification of biomarkers AN - 20027972; 7732047 AB - Probably no topic has generated more excitement in the world of proteomics than the search for biomarkers. This excitement has been generated by two realities: the constant need for better biomarkers that can be used for disease diagnosis and prognosis, and the recent developments in proteomic technologies that are capable of scanning the individual proteins within varying complex clinical samples. Ideally a biomarker would be assayable from a noninvasively collected sample, therefore, much of the focus in proteomics has been on the analysis of biofluids such as serum, plasma, urine, cerebrospinal fluid, lymph, etc. While the discovery of biomarkers has been elusive, there have been many advances made in the understanding of the proteome content of various biofluids, and in the technologies used for their analysis, that continues to point the research community toward new methods for achieving the ultimate goal of identifying novel disease-specific biomarkers. In this review, we will describe and discuss many of the proteomic approaches taken in an attempt to find novel biomarkers in serum, plasma, and lymph. JF - Proteomics Clinical Applications AU - Meng, Z AU - Veenstra, T D AD - SAIC-Frederick Inc., National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702, USA, veenstra@ncifcrf.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 747 EP - 757 VL - 1 IS - 8 SN - 1862-8346, 1862-8346 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Prognosis KW - Therapeutic applications KW - Lymph KW - biomarkers KW - Cerebrospinal fluid KW - Scanning KW - Urine KW - Reviews KW - proteomics KW - W 30905:Medical Applications KW - F 06900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20027972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proteomics+Clinical+Applications&rft.atitle=Proteomic+analysis+of+serum%2C+plasma%2C+and+lymph+for+the+identification+of+biomarkers&rft.au=Meng%2C+Z%3BVeenstra%2C+T+D&rft.aulast=Meng&rft.aufirst=Z&rft.date=2007-08-01&rft.volume=1&rft.issue=8&rft.spage=747&rft.isbn=&rft.btitle=&rft.title=Proteomics+Clinical+Applications&rft.issn=18628346&rft_id=info:doi/10.1002%2Fprca.200700243 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - biomarkers; proteomics; Lymph; Urine; Scanning; Reviews; Therapeutic applications; Cerebrospinal fluid; Prognosis DO - http://dx.doi.org/10.1002/prca.200700243 ER - TY - JOUR T1 - Activity against Human Immunodeficiency Virus Type 1, Intracellular Metabolism, and Effects on Human DNA Polymerases of 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine AN - 19990366; 7527646 AB - We examined the intracytoplasmic anabolism and kinetics of antiviral activity against human immunodeficiency virus type 1 (HIV-1) of a nucleoside reverse transcriptase inhibitor, 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA), which has potent activity against wild-type and multidrug-resistant HIV-1 strains. When CEM cells were exposed to 0.1 mu M [ super(3)H]EFdA or [ super(3)H]3'-azido-2',3'-dideoxythymidine (AZT) for 6 h, the intracellular EFdA-triphosphate (TP) level was 91.6 pmol/10 super(9) cells, while that of AZT was 396.5 pmol/10 super(9) cells. When CEM cells were exposed to 10 mu M [ super(3)H]EFdA, the amount of EFdA-TP increased by 22-fold (2,090 pmol/10 super(9) cells), while the amount of [ super(3)H]AZT-TP increased only moderately by 2.4-fold (970 pmol/10 super(9) cells). The intracellular half-life values of EFdA-TP and AZT-TP were similar to 17 and similar to 3 h, respectively. When MT-4 cells were cultured with 0.01 mu M EFdA for 24 h, thoroughly washed to remove EFdA, further cultured without EFdA for various periods of time, exposed to HIV-1 sub(NL4-3), and cultured for an additional 5 days, the protection values were 75 and 47%, respectively, after 24 and 48 h with no drug incubation, while those with 1 mu M AZT were 55 and 9.2%, respectively. The 50% inhibitory concentration values of EFdA-TP against human polymerases alpha , {szligbeta}, and gamma were >100 mu M, >100 mu M, and 10 mu M, respectively, while those of ddA-TP were >100 mu M, 0.2 mu M, and 0.2 mu M, respectively. These data warrant further development of EFdA as a potential therapeutic agent for those patients who harbor wild-type HIV-1 and/or multidrug-resistant variants. JF - Antimicrobial Agents & Chemotherapy AU - Nakata, Hirotomo AU - Amano, Masayuki AU - Koh, Yasuhiro AU - Kodama, Eiichi AU - Yang, Guangwei AU - Bailey, Christopher M AU - Kohgo, Satoru AU - Hayakawa, Hiroyuki AU - Matsuoka, Masao AU - Anderson, Karen S AU - Cheng, Yung-Chi AU - Mitsuya, Hiroaki AD - Department of Infectious Diseases. Department of Hematology, Kumamoto University School of Medicine, Kumamoto 860-8556, Japan. Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892. Laboratory of Virus Immunology, Institute for Virus Research, Kyoto University, Kyoto 606-8507, Japan. Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520. Biochemicals Division, Yamasa Corporation, Chosi 288-0056, Japan Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 2701 EP - 2708 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 51 IS - 8 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Data processing KW - Antiviral agents KW - DNA-directed DNA polymerase KW - Drug resistance KW - Kinetics KW - Human immunodeficiency virus 1 KW - Zidovudine KW - Antiviral activity KW - Metabolism KW - nucleoside reverse transcriptase inhibitors KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19990366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Activity+against+Human+Immunodeficiency+Virus+Type+1%2C+Intracellular+Metabolism%2C+and+Effects+on+Human+DNA+Polymerases+of+4%27-Ethynyl-2-Fluoro-2%27-Deoxyadenosine&rft.au=Nakata%2C+Hirotomo%3BAmano%2C+Masayuki%3BKoh%2C+Yasuhiro%3BKodama%2C+Eiichi%3BYang%2C+Guangwei%3BBailey%2C+Christopher+M%3BKohgo%2C+Satoru%3BHayakawa%2C+Hiroyuki%3BMatsuoka%2C+Masao%3BAnderson%2C+Karen+S%3BCheng%2C+Yung-Chi%3BMitsuya%2C+Hiroaki&rft.aulast=Nakata&rft.aufirst=Hirotomo&rft.date=2007-08-01&rft.volume=51&rft.issue=8&rft.spage=2701&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Data processing; Antiviral agents; Kinetics; Drug resistance; DNA-directed DNA polymerase; Zidovudine; Antiviral activity; Metabolism; nucleoside reverse transcriptase inhibitors; Human immunodeficiency virus 1 ER - TY - JOUR T1 - Transgenic expression of human thymidylate synthase accelerates the development of hyperplasia and tumors in the endocrine pancreas AN - 19881378; 7491296 AB - Thymidylate synthase (TS) is an essential enzyme for DNA synthesis and repair and elevated levels of TS have been identified as an important prognostic biomarker for colorectal cancer and several other common human malignancies. In addition, TS gene expression has been linked with cell-cycle regulation and cell proliferation through the ability of retinoblastoma protein to repress the transcriptional activation of E2F target genes such as TS. Therefore, overproduction of TS could participate in the progression to a neoplastic phenotype. Consistent with this model, a recent study has suggested that ectopic TS expression can induce a transformed phenotype in mammalian cells. To investigate the role of deregulated TS activity in tumor development, we generated transgenic mice that express high levels of catalytically active human TS (hTS) exclusively in the pancreas and low levels of hTS in multiple other tissues. Analyses of pancreatic tissue in TS transgenic mice revealed abnormalities within the endocrine pancreas, ranging from pancreatic islet hyperplasia to the detection of islet cell tumors. Overexpression of hTS in murine islets provides a new model to study genetic alterations associated with the progression from normal cells to hyperplasia to islet cell tumors, and suggests that this mouse model may be useful for regulating TS activity in vivo for development of cancer prevention and new therapies. JF - Oncogene AU - Chen, M AU - Rahman, L AU - Voeller, D AU - Kastanos, E AU - Yang, S X AU - Feigenbaum, L AU - Allegra, C AU - Kaye, F J AU - Steeg, P AU - Zajac-Kaye, M AD - Molecular Therapeutics Program, Center for Cancer Research, Bethesda, MD, USA, kayem@exchange.nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 4817 EP - 4824 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 26 IS - 33 SN - 0950-9232, 0950-9232 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Oncogenes & Growth Factors Abstracts KW - thymidylate synthase KW - transgenic model KW - islet cell adenoma KW - endocrine pancreas KW - DNA biosynthesis KW - Pancreas KW - Animal models KW - Colorectal cancer KW - Retinoblastoma protein KW - Enzymes KW - Islet cells KW - Islets of Langerhans KW - double prime ts gene KW - Tumors KW - DNA repair KW - Transgenic mice KW - biomarkers KW - Thymidylate synthase KW - Hyperplasia KW - Malignancy KW - Mammalian cells KW - Cell proliferation KW - double prime E2F protein KW - Transcription activation KW - W 30925:Genetic Engineering KW - N 14820:DNA Metabolism & Structure KW - B 26670:Tumor Suppressors KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19881378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Transgenic+expression+of+human+thymidylate+synthase+accelerates+the+development+of+hyperplasia+and+tumors+in+the+endocrine+pancreas&rft.au=Chen%2C+M%3BRahman%2C+L%3BVoeller%2C+D%3BKastanos%2C+E%3BYang%2C+S+X%3BFeigenbaum%2C+L%3BAllegra%2C+C%3BKaye%2C+F+J%3BSteeg%2C+P%3BZajac-Kaye%2C+M&rft.aulast=Chen&rft.aufirst=M&rft.date=2007-08-01&rft.volume=26&rft.issue=33&rft.spage=4817&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/10.1038%2Fsj.onc.1210273 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - DNA biosynthesis; Pancreas; Retinoblastoma protein; Colorectal cancer; Animal models; Enzymes; double prime ts gene; Islets of Langerhans; Islet cells; Tumors; Transgenic mice; DNA repair; biomarkers; Thymidylate synthase; Malignancy; Hyperplasia; Mammalian cells; double prime E2F protein; Cell proliferation; Transcription activation DO - http://dx.doi.org/10.1038/sj.onc.1210273 ER - TY - JOUR T1 - Filarial Parasites Induce NK Cell Activation, Type 1 and Type 2 Cytokine Secretion, and Subsequent Apoptotic Cell Death AN - 19880868; 7558616 AB - NK cells are an important source of early cytokine production in a variety of intracellular viral, bacterial, and protozoan infections; however, the role of NK cells in extracellular parasitic infections such as filarial infections is not well-defined. To investigate the role of NK cells in filarial infections, we have used an in vitro model system of culturing live infective-stage larvae (L3) or live microfilariae (Mf) of Brugia malayi, a causative agent of human lymphatic filariasis, with PBMC of normal individuals. We found that NK cells undergo early cell activation and produce IFN- gamma and TNF- alpha within 24 h after stimulation with both live L3 and Mf. Interestingly, NK cells also express IL-4 and IL-5 at this time point in response to live Mf but not L3. This is accompanied by significant alterations in NK cell expression of costimulatory molecules and natural cytotoxicity receptors. This activation is dependent on the presence of monocytes in the culture, IL-12, and direct contact with live parasites. The early activation event is subsequently followed by apoptosis of NK cells involving a caspase-dependent mechanism in response to live L3 but not live Mf. Thus, the NK cell-parasite interaction is complex, with filarial parasites inducing NK cell activation and cytokine secretion and finally NK cell apoptosis, which may provide an additional mechanism of down-regulating the host immune response. JF - Journal of Immunology AU - Babu, Subash AU - Blauvelt, Carla P AU - Nutman, Thomas B AD - Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 2445 EP - 2456 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 179 IS - 4 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - gamma -Interferon KW - Parasites KW - Interleukin 4 KW - Apoptosis KW - Interleukin 5 KW - Larvae KW - Natural killer cells KW - Filariasis KW - Cell culture KW - Infection KW - Cell activation KW - Interleukin 12 KW - Costimulator KW - Cytotoxicity KW - Peripheral blood mononuclear cells KW - Brugia malayi KW - Cytokines KW - Tumor necrosis factor- alpha KW - Immune response KW - Monocytes KW - K 03350:Immunology KW - V 22350:Immunology KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19880868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Filarial+Parasites+Induce+NK+Cell+Activation%2C+Type+1+and+Type+2+Cytokine+Secretion%2C+and+Subsequent+Apoptotic+Cell+Death&rft.au=Babu%2C+Subash%3BBlauvelt%2C+Carla+P%3BNutman%2C+Thomas+B&rft.aulast=Babu&rft.aufirst=Subash&rft.date=2007-08-01&rft.volume=179&rft.issue=4&rft.spage=2445&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Parasites; gamma -Interferon; Interleukin 4; Interleukin 5; Apoptosis; Filariasis; Natural killer cells; Larvae; Cell culture; Infection; Cell activation; Costimulator; Interleukin 12; Peripheral blood mononuclear cells; Cytotoxicity; Cytokines; Monocytes; Immune response; Tumor necrosis factor- alpha; Brugia malayi ER - TY - JOUR T1 - Adenoviral Gene Transfer in Bovine Adrenomedullary and Murine Pheochromocytoma Cells: Potential Clinical and Therapeutic Relevance AN - 19866033; 7530079 AB - Recombinant adenoviruses (rAd) have been widely used as gene transfer vectors both in the laboratory and in human clinical trials. In the present study, we investigated the effects of adenoviral-mediated gene transfer in primary bovine adrenal chromaffin cells (BACC) and a murine pheochromocytoma cell line (MPC). Cells were infected with one of three nonreplicating E1/E3-deleted (E1 super(-)/E3 super(-)) rAd vectors: Ad.GFP, expressing a green fluorescent protein (GFP); Ad.null, expressing no transgene; or Ad.C2.TK, expressing the herpes simplex virus-1 thymidine kinase gene (TK). Forty-eight hours after exposure to Ad.GFP, the percentage of GFP-expressing BACC ranged from 23.5-97% in a dose-dependent manner and similarly from 1.06-84.4% in the MPC, indicating that adrenomedullary cells are a potentially valuable target for adenoviral-mediated gene transfer. Ultrastructural analysis, however, revealed profound changes in the nucleus and mitochondria of cells infected with rAd. Furthermore, infection of BACC with Ad.null was accompanied by a time- and dose-dependent decrease in cell survival due to the vector alone. Specific whole-cell norepinephrine uptake was also decreased in a time- and dose-dependent fashion in BACC. Infection of MPC cells with the Ad.C2.TK vector sensitized them to the cytotoxic effect of the antiviral drug ganciclovir, in direct proportion to the fraction of cells infected with the virus. We conclude that rAd may alter the structural and functional integrity of adrenomedullary cells, potentially interfering with the normal stress response. At the same time, in light of their ability to effectively deliver and express genes in pheochromocytoma cells, they may be applicable to the gene therapy of adrenomedullary tumors. JF - Endocrinology AU - Alesci, Salvatore AU - Perera, Shiromi M AU - Lai, Edwin W AU - Kukura, Christina AU - Abu-Asab, Mones AU - Tsokos, Maria AU - Morris, John C AU - Pacak, Karel AD - Clinical Neuroendocrinology Branch (S.A.), National Institute of Mental Health Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 3900 EP - 3907 PB - Endocrine Society, 8401 Connecticut Ave Suite 900 Chevy Chase MD 20815-5817 USA, [mailto:societyservices@endo-society.org], [URL:http://www.endo-society.org/] VL - 148 IS - 8 SN - 0013-7227, 0013-7227 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Cell survival KW - Gene therapy KW - Green fluorescent protein KW - Mitochondria KW - Ganciclovir KW - Thymidine kinase KW - Tumors KW - Infection KW - Clinical trials KW - Herpes simplex KW - Expression vectors KW - Cytotoxicity KW - Pheochromocytoma cells KW - Antiviral agents KW - Structure-function relationships KW - Gene transfer KW - Chromaffin cells KW - Norepinephrine KW - Protein-tyrosine kinase KW - Nuclei KW - W 30905:Medical Applications KW - G 07730:Development & Cell Cycle KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19866033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Adenoviral+Gene+Transfer+in+Bovine+Adrenomedullary+and+Murine+Pheochromocytoma+Cells%3A+Potential+Clinical+and+Therapeutic+Relevance&rft.au=Alesci%2C+Salvatore%3BPerera%2C+Shiromi+M%3BLai%2C+Edwin+W%3BKukura%2C+Christina%3BAbu-Asab%2C+Mones%3BTsokos%2C+Maria%3BMorris%2C+John+C%3BPacak%2C+Karel&rft.aulast=Alesci&rft.aufirst=Salvatore&rft.date=2007-08-01&rft.volume=148&rft.issue=8&rft.spage=3900&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell survival; Gene therapy; Green fluorescent protein; Mitochondria; Thymidine kinase; Ganciclovir; Tumors; Infection; Herpes simplex; Clinical trials; Expression vectors; Cytotoxicity; Pheochromocytoma cells; Antiviral agents; Gene transfer; Structure-function relationships; Protein-tyrosine kinase; Norepinephrine; Chromaffin cells; Nuclei ER - TY - JOUR T1 - Human Immunodeficiency Virus Type 1 Vif Inhibits Packaging and Antiviral Activity of a Degradation-Resistant APOBEC3G Variant AN - 19862527; 7532261 AB - Human immunodeficiency virus type 1 (HIV-1) Vif counteracts the antiviral activity of the human cytidine deaminase APOBEC3G (APO3G) by inhibiting its incorporation into virions. This has been attributed to the Vif-induced degradation of APO3G by cytoplasmic proteasomes. We recently demonstrated that although APO3G has a natural tendency to form RNA-dependent homo-multimers, multimerization was not essential for encapsidation into HIV-1 virions or antiviral activity. We now demonstrate that a multimerization-defective APO3G variant (APO3G C97A) is able to assemble into RNase-sensitive high-molecular-mass (HMM) complexes, suggesting that homo-multimerization of APO3G and assembly into HMM complexes are unrelated RNA-dependent processes. Interestingly, APO3G C97A was highly resistant to Vif-induced degradation even though the two proteins were found to interact in coimmunoprecipitation experiments and exhibited partial colocalization in transfected HeLa cells. Surprisingly, encapsidation and antiviral activity of APO3G C97A were both inhibited by Vif despite resistance to degradation. These results demonstrate that targeting of APO3G to proteasome degradation and interference with viral encapsidation are distinct functional properties of Vif. JF - Journal of Virology AU - Opi, Sandrine AU - Kao, Sandra AU - Goila-Gaur, Ritu AU - Khan, Mohammad A AU - Miyagi, Eri AU - Takeuchi, Hiroaki AU - Strebel, Klaus AD - Laboratory of Molecular Microbiology, Viral Biochemistry Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 4, Room 310, 4 Center Drive, MSC 0460, Bethesda, Maryland 20892-0460 Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 8236 EP - 8246 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 81 IS - 15 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Virions KW - Human immunodeficiency virus 1 KW - proteasomes KW - Encapsidation KW - Antiviral activity KW - Cytidine deaminase KW - Packaging KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19862527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Human+Immunodeficiency+Virus+Type+1+Vif+Inhibits+Packaging+and+Antiviral+Activity+of+a+Degradation-Resistant+APOBEC3G+Variant&rft.au=Opi%2C+Sandrine%3BKao%2C+Sandra%3BGoila-Gaur%2C+Ritu%3BKhan%2C+Mohammad+A%3BMiyagi%2C+Eri%3BTakeuchi%2C+Hiroaki%3BStrebel%2C+Klaus&rft.aulast=Opi&rft.aufirst=Sandrine&rft.date=2007-08-01&rft.volume=81&rft.issue=15&rft.spage=8236&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Virions; proteasomes; Encapsidation; Antiviral activity; Cytidine deaminase; Packaging; Human immunodeficiency virus 1 ER - TY - JOUR T1 - Profiling Microdissected Epithelium and Stroma to Model Genomic Signatures for Cervical Carcinogenesis Accommodating for Covariates AN - 19858126; 7555701 AB - This study is the first comprehensive, integrated approach to examine grade-specific changes in gene expression along the entire neoplastic spectrum of cervical intraepithelial neoplasia (CIN) in the process of cervical carcinogenesis. This was accomplished by identifying gene expression signatures of disease progression using cDNA microarrays to analyze RNA from laser-captured microdissected epithelium and underlying stroma from normal cervix, graded CINs, cancer, and patient-matched normal cervical tissues. A separate set of samples were subsequently validated using a linear mixed model that is ideal to control for interpatient gene expression profile variation, such as age and race. These validated genes were ultimately used to propose a genomically based model of the early events in cervical neoplastic transformation. In this model, the CIN 1 transition coincides with a proproliferative/immunosuppression gene signature in the epithelium that probably represents the epithelial response to human papillomavirus infection. The CIN 2 transition coincides with a proangiogenic signature, suggesting a cooperative signaling interaction between stroma and tumor cells. Finally, the CIN 3 and squamous cell carcinoma antigen transition coincide with a proinvasive gene signature that may be a response to epithelial tumor cell overcrowding. This work strongly suggests that premalignant cells experience a series of microenvironmental stresses at the epithelium/stroma cell interface that must be overcome to progress into a transformed phenotype and identifies the order of these events in vivo and their association with specific CIN transitions. [Cancer Res 2007; 67(15):7113-23] JF - Cancer Research AU - Gius, David AU - Funk, Margo C AU - Chuang, Eric Y AU - Feng, Sheng AU - Huettner, Phyllis C AU - Nguyen, Loan AU - Bradbury, CMatthew AU - Mishra, Mark AU - Gao, Shuping AU - Buttin, Barbara M AU - Cohn, David E AU - Powell, Matthew A AU - Horowitz, Neil S AU - Whitcomb, Bradford P AU - Rader, Janet S AD - Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland and Division of Gynecologic Oncology, Department of Obstetrics and Gynecology Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 7113 EP - 7123 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 67 IS - 15 SN - 0008-5472, 0008-5472 KW - Virology & AIDS Abstracts; Toxicology Abstracts; Genetics Abstracts KW - Stroma KW - Transformation KW - Age KW - Cervical cancer KW - Stress KW - squamous cell carcinoma KW - Infection KW - DNA microarrays KW - Tumor cells KW - Neoplasia KW - Gene expression KW - RNA KW - Carcinogenesis KW - Epithelium KW - genomics KW - Cervix KW - Races KW - Human papillomavirus KW - Signal transduction KW - Immunosuppression KW - X 24390:Radioactive Materials KW - G 07730:Development & Cell Cycle KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19858126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Profiling+Microdissected+Epithelium+and+Stroma+to+Model+Genomic+Signatures+for+Cervical+Carcinogenesis+Accommodating+for+Covariates&rft.au=Gius%2C+David%3BFunk%2C+Margo+C%3BChuang%2C+Eric+Y%3BFeng%2C+Sheng%3BHuettner%2C+Phyllis+C%3BNguyen%2C+Loan%3BBradbury%2C+CMatthew%3BMishra%2C+Mark%3BGao%2C+Shuping%3BButtin%2C+Barbara+M%3BCohn%2C+David+E%3BPowell%2C+Matthew+A%3BHorowitz%2C+Neil+S%3BWhitcomb%2C+Bradford+P%3BRader%2C+Janet+S&rft.aulast=Gius&rft.aufirst=David&rft.date=2007-08-01&rft.volume=67&rft.issue=15&rft.spage=7113&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Transformation; Stroma; Age; Cervical cancer; Stress; squamous cell carcinoma; Infection; Tumor cells; DNA microarrays; Neoplasia; Gene expression; RNA; Carcinogenesis; Epithelium; genomics; Cervix; Races; Immunosuppression; Signal transduction; Human papillomavirus ER - TY - JOUR T1 - Immune responses and gene expression in white shrimp, Litopenaeus vannamei, induced by Lactobacillus plantarum AN - 19854873; 7434376 AB - The total haemocyte counts, phenoloxidase (PO) activity, respiratory bursts, superoxide dismutase (SOD) activity, and phagocytic activity and clearance efficiency to Vibrio alginolyticus, as well as prophenoloxidase (proPO), lipopolysaccharide- and beta -1,3-glucan-binding protein (LGBP), serine protein (SP), and peroxinectin (PE) mRNA transcription of L. vannamei, and its susceptibility to V. alginolyticus when the shrimp were fed diets containing Lactobacillus plantarum at 0 (control), 10 super(7), and 10 super(1) super(0)cfu(kg diet) super(-) super(1) for 48 and 168h were evaluated. The results indicated that PO activity, SOD activity, clearance efficiency to V. alginolyticus, proPO and PE mRNA transcription, and the survival rate after challenge with V. alginolyticus all significantly increased, but the total haemocyte counts significantly decreased in shrimp fed a diet containing Lac. plantarum at 10 super(1) super(0)cfu(kg diet) super(-) super(1) for 168h. However, no significant differences in phagocytosis, LGBP, or SP mRNA expression of shrimp were observed among the different treatments. It was concluded that administration of Lac. plantarum in the diet at 10 super(1) super(0)cfu(kg diet) super(-) super(1) induced immune modulation and enhanced the immune ability of L. vannamei, and increased its resistance to V. alginolyticus infection. JF - Fish & Shellfish Immunology AU - Chiu, CH AU - Guu, Y K AU - Liu, CH AU - Pan, T M AU - Cheng, W AD - National Pingtung University of Science and Technology, 1 Sheuh Fu Road, Nei Pu Hsiang, Pingtung 91201, Taiwan, tmpan@ntu.edu.tw Y1 - 2007/08// PY - 2007 DA - August 2007 SP - 364 EP - 377 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl] VL - 23 IS - 2 SN - 1050-4648, 1050-4648 KW - Whiteleg shrimp KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources; Oceanic Abstracts; Immunology Abstracts KW - Lactobacillus plantarum KW - Survival KW - Vibrio alginolyticus KW - Infection KW - Immunomodulation KW - Feed composition KW - Gene expression KW - Respiratory burst KW - Superoxide dismutase KW - Phagocytes KW - prophenoloxidase KW - Hemocytes KW - Litopenaeus vannamei KW - Lipopolysaccharides KW - Blood cells KW - Phagocytosis KW - Marine crustaceans KW - Serine KW - Diets KW - Marine KW - Phenoloxidase KW - Transcription KW - Substance P KW - Microorganisms KW - Feeding experiments KW - Metabolism KW - O 1070:Ecology/Community Studies KW - G 07800:Plants and Algae KW - J 02350:Immunology KW - F 06940:Fish Immunity KW - Q1 08425:Nutrition and feeding habits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19854873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fish+%26+Shellfish+Immunology&rft.atitle=Immune+responses+and+gene+expression+in+white+shrimp%2C+Litopenaeus+vannamei%2C+induced+by+Lactobacillus+plantarum&rft.au=Chiu%2C+CH%3BGuu%2C+Y+K%3BLiu%2C+CH%3BPan%2C+T+M%3BCheng%2C+W&rft.aulast=Chiu&rft.aufirst=CH&rft.date=2007-08-01&rft.volume=23&rft.issue=2&rft.spage=364&rft.isbn=&rft.btitle=&rft.title=Fish+%26+Shellfish+Immunology&rft.issn=10504648&rft_id=info:doi/10.1016%2Fj.fsi.2006.11.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Gene expression; Diets; Microorganisms; Feeding experiments; Blood cells; Phagocytosis; Marine crustaceans; Metabolism; Feed composition; Phenoloxidase; Transcription; Survival; Infection; Immunomodulation; Substance P; Respiratory burst; Phagocytes; Superoxide dismutase; Hemocytes; prophenoloxidase; Lipopolysaccharides; Serine; Lactobacillus plantarum; Litopenaeus vannamei; Vibrio alginolyticus; Marine DO - http://dx.doi.org/10.1016/j.fsi.2006.11.010 ER - TY - JOUR T1 - Varicella-Zoster Virus IE63, a Major Viral Latency Protein, Is Required To Inhibit the Alpha Interferon-Induced Antiviral Response AN - 19842224; 7532222 AB - Varicella-zoster virus (VZV) open reading frame 63 (ORF63) is the most abundant transcript expressed during latency in human sensory ganglia. VZV with ORF63 deleted is impaired for replication in melanoma cells and fibroblasts and for latency in rodents. We found that replication of the ORF63 deletion mutant is fully complemented in U2OS cells, which have been shown to complement the growth of herpes simplex virus type 1 (HSV-1) ICP0 mutants. Since HSV-1 ICP0 mutants are hypersensitive to alpha interferon (IFN- alpha ), we examined the effect of IFN- alpha on VZV replication. Replication of the ORF63 mutant in melanoma cells was severely inhibited in the presence of IFN- alpha , in contrast to other VZV mutants that were similarly impaired for replication or to parental virus. The VZV ORF63 mutant was not hypersensitive to IFN- gamma . IFN- alpha inhibited viral-gene expression in cells infected with the ORF63 mutant at a posttranscriptional level. Since IFN- alpha stimulates gene products that can phosphorylate the alpha subunit of eukaryotic initiation factor 2 (eIF-2 alpha ) and inhibit translation, we determined whether cells infected with the ORF63 mutant had increased phosphorylation of eIF-2 alpha compared with cells infected with parental virus. While phosphorylated eIF-2 alpha was undetectable in uninfected cells or cells infected with parental virus, it was present in cells infected with the ORF63 mutant. Conversely, expression of IE63 (encoded by ORF63) in the absence of other viral proteins inhibited phosphorylation of eIF-2 alpha . Since IFN- alpha has been shown to limit VZV replication in human skin xenografts, the ability of VZV IE63 to block the effects of the cytokine may play a critical role in VZV pathogenesis. JF - Journal of Virology AU - Ambagala, Aruna PN AU - Cohen, Jeffrey I AD - Medical Virology Section, Laboratory of Clinical Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 7844 EP - 7851 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 81 IS - 15 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts KW - Initiation factors KW - Translation KW - gamma -Interferon KW - Skin KW - Deletion mutant KW - Sensory neurons KW - Replication KW - Herpes simplex virus 1 KW - Transcription KW - Fibroblasts KW - Melanoma KW - Phosphorylation KW - alpha -Interferon KW - Varicella-zoster virus KW - Cytokines KW - Initiation factor eIF-2 KW - Xenografts KW - Post-transcription KW - Open reading frames KW - A 01340:Antibiotics & Antimicrobials KW - V 22350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19842224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Varicella-Zoster+Virus+IE63%2C+a+Major+Viral+Latency+Protein%2C+Is+Required+To+Inhibit+the+Alpha+Interferon-Induced+Antiviral+Response&rft.au=Ambagala%2C+Aruna+PN%3BCohen%2C+Jeffrey+I&rft.aulast=Ambagala&rft.aufirst=Aruna&rft.date=2007-08-01&rft.volume=81&rft.issue=15&rft.spage=7844&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Translation; Initiation factors; Deletion mutant; Skin; Sensory neurons; Replication; Transcription; Melanoma; Fibroblasts; Phosphorylation; alpha -Interferon; Cytokines; Xenografts; Initiation factor eIF-2; Post-transcription; Open reading frames; Varicella-zoster virus; Herpes simplex virus 1 ER - TY - JOUR T1 - WY-14,643-Induced Cell Proliferation and Oxidative Stress in Mouse Liver are Independent of NADPH Oxidase AN - 19785211; 7533783 AB - Long-term exposure of rodents to peroxisome proliferators leads to increases in peroxisomes, hepatocellular proliferation, oxidative damage, suppressed apoptosis, and ultimately results in the development of hepatic adenomas and carcinomas. Peroxisome proliferators-activated receptor (PPAR) alpha was shown to be required for these pleiotropic responses; however, Kupffer cells, resident liver macrophages, were also identified as playing a role in peroxisome proliferators-induced effects, independently of PPAR alpha . Previous studies showed that oxidants from NADPH (nicotinamide adenine dinucleotide phosphate, reduced) oxidase mediate acute effects of peroxisome proliferators in rodent liver. To determine if Kupffer cell oxidants are also involved in chronic effects, NADPH oxidase-deficient (p47 super(phox)-null) mice were fed 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio acetic acid (WY-14,643)-containing diet (0.1% wt/wt) for 1 week, 5 weeks, or 5 months along with Ppar alpha -null and wild type mice. As expected, no change in liver size, cell replication rates, or other phenotypic effects of peroxisome proliferators were observed in Ppar alpha -null mice. Through 5 months of treatment, the p47 super(phox)-null and wild type mice exhibited peroxisome proliferators-induced adverse liver effects, along with increased oxidative DNA damage and increased cell proliferation, a response that is potentially mediated through nuclear factor kappa B (NFkB). Suppressed apoptosis caused by WY-14,643 was dependent on both NADPH oxidase and PPAR alpha . Collectively, these findings suggest that involvement of Kupffer cells in WY-14,643-induced parenchymal cell proliferation and oxidative stress in rodent liver is an acute phenomenon that is not relevant to long-term exposure, but they are still involved in chronic apoptotic responses. These results provide new insight for understanding the mode of hepatocarcinogenic action of peroxisome proliferators. JF - Toxicological Sciences AU - Woods, Courtney G AU - Burns, Amanda M AU - Bradford, Blair U AU - Ross, Pamela K AU - Kosyk, Oksana AU - Swenberg, James A AU - Cunningham, Michael L AU - Rusyn, Ivan AD - Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599-7431. National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 366 EP - 374 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 98 IS - 2 SN - 1096-6080, 1096-6080 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Macrophages KW - Diets KW - NADPH KW - Apoptosis KW - Hepatocytes KW - Replication KW - Acetic acid KW - Peroxisomes KW - NF- Kappa B protein KW - NADP KW - Carcinoma KW - Acute effects KW - DNA damage KW - Kupffer cells KW - Oxidative stress KW - Chronic effects KW - Cell size KW - Liver KW - NAD(P)H oxidase KW - Cell proliferation KW - Adenoma KW - Oxidants KW - N 14820:DNA Metabolism & Structure KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19785211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=WY-14%2C643-Induced+Cell+Proliferation+and+Oxidative+Stress+in+Mouse+Liver+are+Independent+of+NADPH+Oxidase&rft.au=Woods%2C+Courtney+G%3BBurns%2C+Amanda+M%3BBradford%2C+Blair+U%3BRoss%2C+Pamela+K%3BKosyk%2C+Oksana%3BSwenberg%2C+James+A%3BCunningham%2C+Michael+L%3BRusyn%2C+Ivan&rft.aulast=Woods&rft.aufirst=Courtney&rft.date=2007-08-01&rft.volume=98&rft.issue=2&rft.spage=366&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Diets; Macrophages; Apoptosis; NADPH; Replication; Hepatocytes; Acetic acid; Peroxisomes; Carcinoma; NADP; NF- Kappa B protein; Acute effects; Kupffer cells; DNA damage; Oxidative stress; Chronic effects; Cell size; Liver; NAD(P)H oxidase; Cell proliferation; Adenoma; Oxidants ER - TY - JOUR T1 - Identification and Characterization of CPS1 as a Hyaluronic Acid Synthase Contributing to the Pathogenesis of Cryptococcus neoformans Infection AN - 19785063; 7556635 AB - Cryptococcus neoformans is a pathogenic yeast that often causes devastating meningoencephalitis in immunocompromised individuals. We have previously identified the C. neoformans CPS1 gene, which is required for a capsular layer on the outer cell wall. In this report, we investigate the function of the CPS1 gene and its pathogenesis. We demonstrated that treatment of yeast with either 4-methylumbelliferone or hyaluronidase resulted in a reduction of the level of C. neoformans binding to human brain microvascular endothelial cells (HBMEC). Yeast extracellular structures were also altered accordingly in hyaluronidase-treated cells. Furthermore, observation of yeast strains with different hyaluronic acid contents showed that the ability to bind to HBMEC is proportional to the hyaluronic acid content. A killing assay with Caenorhabditis elegans demonstrated that the CPS1 wild-type strain is more virulent than the cps1 Delta strain. When CPS1 is expressed in Saccharomyces cerevisiae and Escherichia coli, hyaluronic acid can be detected in the cells. Additionally, we determined by fluorophore-assisted carbohydrate electrophoretic analysis that hyaluronic acid is a component of the C. neoformans capsule. The size of hyaluronic acid molecules is evaluated by gel filtration and transmission electron microscopy studies. Together, our results support that C. neoformans CPS1 encodes hyaluronic acid synthase and that its product, hyaluronic acid, plays a role as an adhesion molecule during the association of endothelial cells with yeast. JF - Eukaryotic Cell AU - Jong, Ambrose AU - Wu, Chun-Hua AU - Chen, Han-Min AU - Luo, Feng AU - Kwon-Chung, Kyung J AU - Chang, Yun C AU - LaMunyon, Craig W AU - Plaas, Anna AU - Huang, Sheng-He AD - Divisions of Hematology-Oncology. Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, California 90027. Department of Life Science, Fu-Jen University, Taiwan, Republic of China. Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892. Department of Biological Sciences, California State Polytechnic University, Pomona, California 91768. Section of Rheumatology, Rush University, Chicago, Illinois 60612 Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 1486 EP - 1496 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 6 IS - 8 SN - 1535-9778, 1535-9778 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Hyaluronic acid KW - Microvasculature KW - Transmission electron microscopy KW - Meningoencephalitis KW - Brain KW - Infection KW - Saccharomyces cerevisiae KW - Endothelial cells KW - Filtration KW - Cryptococcus neoformans KW - Caenorhabditis elegans KW - Escherichia coli KW - Carbohydrates KW - Hyaluronoglucuronidase KW - Cell adhesion molecules KW - Cell walls KW - K 03330:Biochemistry KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19785063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eukaryotic+Cell&rft.atitle=Identification+and+Characterization+of+CPS1+as+a+Hyaluronic+Acid+Synthase+Contributing+to+the+Pathogenesis+of+Cryptococcus+neoformans+Infection&rft.au=Jong%2C+Ambrose%3BWu%2C+Chun-Hua%3BChen%2C+Han-Min%3BLuo%2C+Feng%3BKwon-Chung%2C+Kyung+J%3BChang%2C+Yun+C%3BLaMunyon%2C+Craig+W%3BPlaas%2C+Anna%3BHuang%2C+Sheng-He&rft.aulast=Jong&rft.aufirst=Ambrose&rft.date=2007-08-01&rft.volume=6&rft.issue=8&rft.spage=1486&rft.isbn=&rft.btitle=&rft.title=Eukaryotic+Cell&rft.issn=15359778&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Endothelial cells; Microvasculature; Hyaluronic acid; Filtration; Transmission electron microscopy; Meningoencephalitis; Brain; Carbohydrates; Infection; Cell adhesion molecules; Hyaluronoglucuronidase; Cell walls; Cryptococcus neoformans; Caenorhabditis elegans; Escherichia coli; Saccharomyces cerevisiae ER - TY - JOUR T1 - Protein backbone chemical shifts predicted from searching a database for torsion angle and sequence homology AN - 19755490; 7569871 AB - Chemical shifts of nuclei in or attached to a protein backbone are exquisitely sensitive to their local environment. A computer program, SPARTA, is described that uses this correlation with local structure to predict protein backbone chemical shifts, given an input three-dimensional structure, by searching a newly generated database for triplets of adjacent residues that provide the best match in phi / psi / chi super(1 )torsion angles and sequence similarity to the query triplet of interest. The database contains super(15)N, super( 1)H super(N), super(1)H super( alpha ), super(13)C super( alpha ), super(13)C super( beta ) and super(13)C' chemical shifts for 200 proteins for which a high resolution X-ray ( less than or equal to 2.4 Aa) structure is available. The relative importance of the weighting factors for the phi / psi / chi super(1) angles and sequence similarity was optimized empirically. The weighted, average secondary shifts of the central residues in the 20 best-matching triplets, after inclusion of nearest neighbor, ring current, and hydrogen bonding effects, are used to predict chemical shifts for the protein of known structure. Validation shows good agreement between the SPARTA-predicted and experimental shifts, with standard deviations of 2.52, 0.51, 0.27, 0.98, 1.07 and 1.08 ppm for super(15)N, super( 1)H super(N), super(1)H super( alpha ), super(13)C super( alpha ), super(13)C super( beta ) and super(13)C', respectively, including outliers. JF - Journal of Biomolecular NMR AU - Shen, Yang AU - Bax, Ad AD - National Institutes of Health, Bethesda, MD, 20892-0520, USA, shenyang@niddk.nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 289 EP - 302 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 38 IS - 4 SN - 0925-2738, 0925-2738 KW - Biotechnology and Bioengineering Abstracts KW - Protein structure KW - Computer programs KW - Databases KW - Standard deviation KW - Homology KW - Hydrogen bonding KW - N.M.R. KW - Nuclei KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19755490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomolecular+NMR&rft.atitle=Protein+backbone+chemical+shifts+predicted+from+searching+a+database+for+torsion+angle+and+sequence+homology&rft.au=Shen%2C+Yang%3BBax%2C+Ad&rft.aulast=Shen&rft.aufirst=Yang&rft.date=2007-08-01&rft.volume=38&rft.issue=4&rft.spage=289&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomolecular+NMR&rft.issn=09252738&rft_id=info:doi/10.1007%2Fs10858-007-9166-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Databases; Protein structure; N.M.R.; Nuclei; Standard deviation; Homology; Computer programs; Hydrogen bonding DO - http://dx.doi.org/10.1007/s10858-007-9166-6 ER - TY - JOUR T1 - Top-down approach in protein RDC data analysis: de novo estimation of the alignment tensor AN - 19748392; 7569872 AB - In solution NMR spectroscopy the residual dipolar coupling (RDC) is invaluable in improving both the precision and accuracy of NMR structures during their structural refinement. The RDC also provides a potential to determine protein structure de novo. These procedures are only effective when an accurate estimate of the alignment tensor has already been made. Here we present a top-down approach, starting from the secondary structure elements and finishing at the residue level, for RDC data analysis in order to obtain a better estimate of the alignment tensor. Using only the RDCs from N-H bonds of residues in alpha -helices and CA-CO bonds in beta -strands, we are able to determine the offset and the approximate amplitude of the RDC modulation-curve for each secondary structure element, which are subsequently used as targets for global minimization. The alignment order parameters and the orientation of the major principal axis of individual helix or strand, with respect to the alignment frame, can be determined in each of the eight quadrants of a sphere. The following minimization against RDC of all residues within the helix or strand segment can be carried out with fixed alignment order parameters to improve the accuracy of the orientation. For a helical protein Bax, the three components A sub()xx A sub()yyand A sub()zz of the alignment order can be determined with this method in average to within 2.3% deviation from the values calculated with the available atomic coordinates. Similarly for beta -sheet protein Ubiquitin they agree in average to within 8.5%. The larger discrepancy in beta -strand parameters comes from both the diversity of the beta -sheet structure and the lower precision of CA-CO RDCs. This top-down approach is a robust method for alignment tensor estimation and also holds a promise for providing a protein topological fold using limited sets of RDCs. JF - Journal of Biomolecular NMR AU - Chen, Kang AU - Tjandra, Nico AD - National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 3503, Bethesda, MD, 20892, USA, tjandran@nhlbi.nih.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 303 EP - 313 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 38 IS - 4 SN - 0925-2738, 0925-2738 KW - Biotechnology and Bioengineering Abstracts KW - Protein structure KW - Data processing KW - Magnetic resonance spectroscopy KW - Bax protein KW - Secondary structure KW - N.M.R. KW - Ubiquitin KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19748392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomolecular+NMR&rft.atitle=Top-down+approach+in+protein+RDC+data+analysis%3A+de+novo+estimation+of+the+alignment+tensor&rft.au=Chen%2C+Kang%3BTjandra%2C+Nico&rft.aulast=Chen&rft.aufirst=Kang&rft.date=2007-08-01&rft.volume=38&rft.issue=4&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomolecular+NMR&rft.issn=09252738&rft_id=info:doi/10.1007%2Fs10858-007-9168-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Protein structure; N.M.R.; Data processing; Secondary structure; Ubiquitin; Bax protein; Magnetic resonance spectroscopy DO - http://dx.doi.org/10.1007/s10858-007-9168-4 ER - TY - JOUR T1 - Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits AN - 19746163; 7560481 AB - The innate immune system senses the invasion of pathogenic microorganisms and tissue injury through Toll-like receptors (TLR), a mechanism thought to be limited to immune cells. We now report that neurons express several TLRs, and that the levels of TLR2 and -4 are increased in neurons in response to IFN- gamma stimulation and energy deprivation. Neurons from both TLR2 knockout and -4 mutant mice were protected against energy deprivation-induced cell death, which was associated with decreased activation of a proapoptotic signaling cascade involving jun N-terminal kinase and the transcription factor AP-1. TLR2 and -4 expression was increased in cerebral cortical neurons in response to ischemia/reperfusion injury, and the amount of brain damage and neurological deficits caused by a stroke were significantly less in mice deficient in TLR2 or -4 compared with WT control mice. Our findings establish a proapoptotic signaling pathway for TLR2 and -4 in neurons that may render them vulnerable to ischemic death. JF - Proceedings of the National Academy of Sciences, USA AU - Tang, Sung-Chun AU - Arumugam, Thiruma V AU - Xu, Xiangru AU - Cheng, Aiwu AU - Mughal, Mohamed R AU - Jo, Dong Gyu AU - Lathia, Justin D AU - Siler, Dominic A AU - Chigurupati, Srinivasulu AU - Ouyang, Xin AU - Magnus, Tim AU - Camandola, Simonetta AU - Mattson, Mark P AD - Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224 Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 13798 EP - 13803 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 34 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; CSA Neurosciences Abstracts; Immunology Abstracts KW - gamma -Interferon KW - Neurological diseases KW - Brain injury KW - Apoptosis KW - Immune system KW - Activator protein 1 KW - Stroke KW - TLR2 protein KW - Energy requirements KW - Ischemia KW - Reperfusion KW - Cell death KW - Cortex KW - Neurons KW - Transcription factors KW - Microorganisms KW - Toll-like receptors KW - Signal transduction KW - A 01490:Miscellaneous KW - N3 11024:Neuroimmunology KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19746163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Pivotal+role+for+neuronal+Toll-like+receptors+in+ischemic+brain+injury+and+functional+deficits&rft.au=Tang%2C+Sung-Chun%3BArumugam%2C+Thiruma+V%3BXu%2C+Xiangru%3BCheng%2C+Aiwu%3BMughal%2C+Mohamed+R%3BJo%2C+Dong+Gyu%3BLathia%2C+Justin+D%3BSiler%2C+Dominic+A%3BChigurupati%2C+Srinivasulu%3BOuyang%2C+Xin%3BMagnus%2C+Tim%3BCamandola%2C+Simonetta%3BMattson%2C+Mark+P&rft.aulast=Tang&rft.aufirst=Sung-Chun&rft.date=2007-08-01&rft.volume=104&rft.issue=34&rft.spage=13798&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Apoptosis; Brain injury; Neurological diseases; Immune system; TLR2 protein; Stroke; Activator protein 1; Energy requirements; Ischemia; Reperfusion; Cell death; Cortex; Transcription factors; Neurons; Microorganisms; Toll-like receptors; Signal transduction ER - TY - JOUR T1 - Patients with Classic Congenital Adrenal Hyperplasia Have Decreased Epinephrine Reserve and Defective Glycemic Control during Prolonged Moderate-Intensity Exercise AN - 19744842; 7558063 AB - CONTEXT: Patients with classic congenital adrenal hyperplasia (CAH) have adrenomedullary dysplasia and hypofunction, and their lack of adrenomedullary reserve has been associated with a defective glucose response to brief high-intensity exercise. OBJECTIVE: Our objective was to assess hormonal, metabolic, and cardiovascular response to prolonged moderate-intensity exercise comparable to brisk walking in adolescents with classic CAH. Subjects and Methods: We compared six adolescents with classic CAH (16-20 yr old) with seven age-, sex-, and body mass index group-matched controls (16-23 yr old) using a 90-min standardized ergometer test. Metabolic, hormonal, and cardiovascular parameters were studied during exercise and recovery. RESULTS: Glucose did not change throughout exercise and recovery for controls, whereas CAH patients showed a steady decline in glucose during exercise with an increase in glucose in the postexercise period. Glucose levels were significantly lower in CAH patients at 60 (P = 0.04), 75 (P = 0.01), and 90 (P = 0.03) min of exercise and 15 (P = 0.02) min post exercise, whereas glucose levels were comparable between the two groups early in exercise and at 30 min (P = 0.19) post exercise. As compared with controls, CAH patients had significantly lower epinephrine (P = 0.002) and cortisol (P less than or equal to 0.001) levels throughout the study and similar norepinephrine, glucagon, and GH levels. Patients with CAH and controls had comparable cardiovascular parameters and perceived level of exertion. Despite having lower glucose levels, insulin levels were slightly higher in CAH patients during the testing period (P = 0.17), suggesting insulin insensitivity. CONCLUSION: CAH patients have defective glycemic control and altered metabolic and hormonal responses during prolonged moderate-intensity exercise comparable to brisk walking. JF - Journal of Clinical Endocrinology and Metabolism AU - Green-Golan, Liza AU - Yates, Catherine AU - Drinkard, Bart AU - VanRyzin, Carol AU - Eisenhofer, Graeme AU - Weise, Martina AU - Merke, Deborah P AD - National Institutes of Health Clinical Center (L.G.-G., C.V., D.P.M.), Pediatric Endocrinology (C.Y.), Walter Reed Army Medical Center, Washington, D.C. 20307 Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 3019 EP - 3024 PB - Endocrine Society, 4350 East West Highway Suite 500 Bethesda MD 20814-4426 USA, [mailto:societyservices@endo-society.org], [URL:http://www.endo-society.org/] VL - 92 IS - 8 SN - 0021-972X, 0021-972X KW - Physical Education Index KW - Recovery KW - Adolescence KW - Body mass KW - Blood glucose KW - Walking KW - Patients KW - Cardiorespiratory KW - Exercise KW - Exertion KW - Hormones KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19744842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Endocrinology+and+Metabolism&rft.atitle=Patients+with+Classic+Congenital+Adrenal+Hyperplasia+Have+Decreased+Epinephrine+Reserve+and+Defective+Glycemic+Control+during+Prolonged+Moderate-Intensity+Exercise&rft.au=Green-Golan%2C+Liza%3BYates%2C+Catherine%3BDrinkard%2C+Bart%3BVanRyzin%2C+Carol%3BEisenhofer%2C+Graeme%3BWeise%2C+Martina%3BMerke%2C+Deborah+P&rft.aulast=Green-Golan&rft.aufirst=Liza&rft.date=2007-08-01&rft.volume=92&rft.issue=8&rft.spage=3019&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Endocrinology+and+Metabolism&rft.issn=0021972X&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Recovery; Body mass; Adolescence; Walking; Blood glucose; Cardiorespiratory; Patients; Exercise; Exertion; Hormones ER - TY - JOUR T1 - CCR4-Expressing T Cell Tumors Can Be Specifically Controlled via Delivery of Toxins to Chemokine Receptors AN - 19744837; 7531794 AB - Expression of chemokine receptors by tumors, specifically CCR4 on cutaneous T cell lymphomas, is often associated with a poor disease outcome. To test the hypothesis that chemokine receptor-expressing tumors can be successfully controlled by delivering toxins through their chemokine receptors, we have generated fusion proteins designated chemotoxins: chemokines fused with toxic moieties that are nontoxic unless delivered into the cell cytosol. We demonstrate that chemokines fused with human RNase eosinophil-derived neurotoxin or with a truncated fragment of Pseudomonas exotoxin 38 are able to specifically kill tumors in vitro upon internalization through their respective chemokine receptors. Moreover, treatment with the thymus and activation-regulated chemokine (CCL17)-expressing chemotoxin efficiently eradicated CCR4-expressing cutaneous T cell lymphoma/leukemia established in NOD-SCID mice. Taken together, this work represents a novel concept that may allow control of growth and dissemination of tumors that use chemokine receptors to metastasize and circumvent immunosurveillance. JF - Journal of Immunology AU - Baatar, Dolgor AU - Olkhanud, Purevdorj AU - Newton, Dianne AU - Sumitomo, Kenya AU - Biragyn, Arya AD - Laboratory of Immunology, Gerontology Research Center, National Institute on Aging, Baltimore, MD 21224. Department of Microbiology, SAIC-Frederick, National Cancer Institute, Frederick, MD 21702 Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 1996 EP - 2004 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 179 IS - 3 SN - 0022-1767, 0022-1767 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - CCL17 protein KW - Thymus KW - Chemokine receptors KW - Pseudomonas KW - Tumors KW - Exotoxins KW - Leukemia KW - Eosinophil-derived neurotoxin KW - Immunosurveillance KW - double prime T-cell lymphoma KW - Lymphocytes T KW - Cytosol KW - Ribonuclease KW - Fusion protein KW - X 24490:Other KW - F 06915:Cancer Immunology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19744837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=CCR4-Expressing+T+Cell+Tumors+Can+Be+Specifically+Controlled+via+Delivery+of+Toxins+to+Chemokine+Receptors&rft.au=Baatar%2C+Dolgor%3BOlkhanud%2C+Purevdorj%3BNewton%2C+Dianne%3BSumitomo%2C+Kenya%3BBiragyn%2C+Arya&rft.aulast=Baatar&rft.aufirst=Dolgor&rft.date=2007-08-01&rft.volume=179&rft.issue=3&rft.spage=1996&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - CCL17 protein; Thymus; Chemokine receptors; Tumors; Exotoxins; Leukemia; Eosinophil-derived neurotoxin; Immunosurveillance; double prime T-cell lymphoma; Cytosol; Lymphocytes T; Ribonuclease; Fusion protein; Pseudomonas ER - TY - JOUR T1 - Transplacental arsenic carcinogenesis in mice AN - 19744741; 7546797 AB - Our work has focused on the carcinogenic effects of in utero arsenic exposure in mice. Our data show that a short period of maternal exposure to inorganic arsenic in the drinking water is an effective, multi-tissue carcinogen in the adult offspring. These studies have been reproduced in three temporally separate studies using two different mouse strains. In these studies pregnant mice were treated with drinking water containing sodium arsenite at up to 85 ppm arsenic from days 8 to 18 of gestation, and the offspring were observed for up to 2 years. The doses used in all these studies were well tolerated by both the dam and offspring. In C3H mice, two separate studies show male offspring exposed to arsenic in utero developed liver carcinoma and adrenal cortical adenoma in a dose-related fashion during adulthood. Prenatally exposed female C3H offspring show dose-related increases in ovarian tumors and lung carcinoma and in proliferative lesions (tumors plus preneoplastic hyperplasia) of the uterus and oviduct. In addition, prenatal arsenic plus postnatal exposure to the tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA) in C3H mice produces excess lung tumors in both sexes and liver tumors in females. Male CD1 mice treated with arsenic in utero develop tumors of the liver and adrenal and renal hyperplasia while females develop tumors of urogenital system, ovary, uterus and adrenal and hyperplasia of the oviduct. Additional postnatal treatment with diethylstilbestrol or tamoxifen after prenatal arsenic in CD1 mice induces urinary bladder transitional cell proliferative lesions, including carcinoma and papilloma, and enhances the carcinogenic response in the liver of both sexes. Overall this model has provided convincing evidence that arsenic is a transplacental carcinogen in mice with the ability to target tissues of potential human relevance, such as the urinary bladder, lung and liver. Transplacental carcinogenesis clearly occurs with other agents in humans and investigating a potential transplacental component of the human carcinogenic response to arsenic should be a research priority. JF - Toxicology and Applied Pharmacology AU - Waalkes, M P AU - Liu, J AU - Diwan, BA AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA, waalkes@niehs.nih.gov Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 271 EP - 280 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 222 IS - 3 SN - 0041-008X, 0041-008X KW - Toxicology Abstracts KW - Prenatal experience KW - Animal models KW - Carcinogens KW - TPA KW - Promoters KW - Gestation KW - Papilloma KW - Diethylstilbestrol KW - Arsenic KW - Uterus KW - Sodium arsenite KW - Lung carcinoma KW - Urinary bladder KW - Tumors KW - Intrauterine exposure KW - Tamoxifen KW - Transplacental carcinogenesis KW - Pregnancy KW - Carcinoma KW - Hyperplasia KW - Oviduct KW - Carcinogenesis KW - Kidney KW - Liver KW - Progeny KW - Ovaries KW - Drinking water KW - Adenoma KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19744741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Transplacental+arsenic+carcinogenesis+in+mice&rft.au=Waalkes%2C+M+P%3BLiu%2C+J%3BDiwan%2C+BA&rft.aulast=Waalkes&rft.aufirst=M&rft.date=2007-08-01&rft.volume=222&rft.issue=3&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2006.12.034 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Prenatal experience; Animal models; Carcinogens; TPA; Promoters; Gestation; Diethylstilbestrol; Papilloma; Uterus; Arsenic; Sodium arsenite; Urinary bladder; Lung carcinoma; Intrauterine exposure; Tumors; Tamoxifen; Transplacental carcinogenesis; Carcinoma; Pregnancy; Hyperplasia; Oviduct; Carcinogenesis; Liver; Kidney; Progeny; Ovaries; Drinking water; Adenoma DO - http://dx.doi.org/10.1016/j.taap.2006.12.034 ER - TY - JOUR T1 - Comparative Mortality for 621 Second Cancers in 29356 Testicular Cancer Survivors and 12420 Matched First Cancers AN - 19743285; 7558835 AB - BACKGROUND: Testicular cancer survivors, many of whom have undergone radiotherapy, are at substantial risk of second cancers. Treatment for testicular cancer may limit treatment options for second cancers, thereby adversely affecting survival after the second cancer. However, no data on outcomes of testicular cancer survivors with second cancers compared to patients with comparable first cancers exist. METHODS: Among 29356 white testicular cancer patients reported to the Surveillance, Epidemiology, and End Results (SEER) program (1973-2002), 621 developed a second cancer with known stage and were matched to a random sample of 12420 white male first cancer patients in the SEER program by cancer site, stage, diagnosis year, and age at diagnosis. Mortality was ascertained through 2002. Cancer-specific and all-cause mortality following second cancers were compared with those of matched first cancers, and rate ratios (RRs) were estimated using proportional hazards analysis. Survival functions were calculated using product-limit estimates. RESULTS: During the study period, 284 testicular cancer survivors with second cancers died, 191 from their second cancer; 5443 matched first cancer patients died, 3929 from their first cancer. Rate ratios for cancer-specific and all-cause mortality for second cancers compared with matched first cancers were 1.05 (95% confidence interval [CI] = 0.90 to 1.23) and 1.09 (95% CI = 0.96 to 1.23), respectively. However, among testicular cancer patients who were diagnosed during 1973-1979, an era in which radiation therapy was given at high doses and to the chest area, all-cause mortality following second cancers at sites below the diaphragm (79 deaths) and second lung cancers (29 deaths) was statistically significantly higher than that from matched first cancers (RR = 1.44, 95% CI = 1.13 to 1.83, and RR = 1.65, 95% CI = 1.12 to 2.42, respectively). CONCLUSIONS: Mortality from second cancers following testicular cancer was similar to matched first cancers, except for selected tumors in the radiotherapy field among testicular cancer patients who were diagnosed during 1973-1979, a time when radiotherapy doses for treatment of testicular cancer were high and chest irradiation was an option in standard practice. JF - Journal of the National Cancer Institute AU - Schairer, Catherine AU - Hisada, Michie AU - Chen, Bingshu E AU - Brown, Linda M AU - Howard, Regan AU - Fossaa, Sophie D AU - Gail, Mitchell AU - Travis, Lois B AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (CS, MH, BEC, LMB, RH, MG, LBT) Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 1248 EP - 1256 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 16 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Radiation therapy KW - Mortality KW - survival KW - Lung cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19743285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Comparative+Mortality+for+621+Second+Cancers+in+29356+Testicular+Cancer+Survivors+and+12420+Matched+First+Cancers&rft.au=Schairer%2C+Catherine%3BHisada%2C+Michie%3BChen%2C+Bingshu+E%3BBrown%2C+Linda+M%3BHoward%2C+Regan%3BFossaa%2C+Sophie+D%3BGail%2C+Mitchell%3BTravis%2C+Lois+B&rft.aulast=Schairer&rft.aufirst=Catherine&rft.date=2007-08-01&rft.volume=99&rft.issue=16&rft.spage=1248&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Radiation therapy; Mortality; survival; Lung cancer ER - TY - JOUR T1 - A bifunctional colchicinoid that binds to the androgen receptor AN - 19742605; 7559645 AB - Castrate-resistant prostate cancer (CRPC) continues to be dependent on the androgen receptor (AR) for disease progression. We have synthesized and evaluated a novel compound that is a conjugate of colchicine and an AR antagonist (cyanonilutamide) designed to inhibit AR function in CRPC. A problem in multifunctional AR-binding compounds is steric hindrance of binding to the embedded hydrophobic AR ligand-binding pocket. Despite the bulky side chain projecting off of the AR-binding moiety, this novel conjugate of colchicine and cyanonilutamide binds to AR with a K sub(i) of 449 nmol/L. Structural modeling of this compound in the AR ligand-binding domain using a combination of rational docking, molecular dynamics, and steered molecular dynamics simulations reveals a basis for how this compound, which has a rigid alkyne linker, is able to bind to AR. Surprisingly, we found that this compound also binds to tubulin and inhibits tubulin function to a greater degree than colchicine itself. The tubulin-inhibiting activity of this compound increases cytoplasmic AR levels in prostate cancer cells. Finally, we found that this compound has greater toxicity against androgen-independent prostate cancer cells than the combination of colchicine and nilutamide. Together, these data point to several ways of inhibiting AR function in CRPC. [Mol Cancer Ther 2007; 6(8):2328-36] JF - Molecular Cancer Therapeutics AU - Sharifi, Nima AU - Hamel, Ernest AU - Lill, Markus A AU - Risbood, Prabhakar AU - Kane, Charles TJr AU - Hossain, Md Tafazzal AU - Jones, Amanda AU - Dalton, James T AU - Farrar, William L AD - Cancer Stem Cell Section, Laboratory of Cancer Prevention, National Cancer Institute at Frederick, Center for Cancer Research, and Toxicology and Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute at Frederick, National Cancer Institute, Frederick, Maryland Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 2328 EP - 2336 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 6 IS - 8 SN - 1535-7163, 1535-7163 KW - Biotechnology and Bioengineering Abstracts KW - Androgen receptors KW - Prostate cancer KW - Hydrophobicity KW - Colchicine KW - Toxicity KW - Tubulin KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19742605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cancer+Therapeutics&rft.atitle=A+bifunctional+colchicinoid+that+binds+to+the+androgen+receptor&rft.au=Sharifi%2C+Nima%3BHamel%2C+Ernest%3BLill%2C+Markus+A%3BRisbood%2C+Prabhakar%3BKane%2C+Charles+TJr%3BHossain%2C+Md+Tafazzal%3BJones%2C+Amanda%3BDalton%2C+James+T%3BFarrar%2C+William+L&rft.aulast=Sharifi&rft.aufirst=Nima&rft.date=2007-08-01&rft.volume=6&rft.issue=8&rft.spage=2328&rft.isbn=&rft.btitle=&rft.title=Molecular+Cancer+Therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Colchicine; Prostate cancer; Androgen receptors; Tubulin; Toxicity; Hydrophobicity ER - TY - JOUR T1 - VISDA: an open-source caBIG super(TM) analytical tool for data clustering and beyond AN - 19738961; 7555217 AB - SUMMARY: VISDA (Visual Statistical Data Analyzer) is a caBIG super(TM) analytical tool for cluster modeling, visualization and discovery that has met silver-level compatibility under the caBIG initiative. Being statistically principled and visually interfaced, VISDA exploits both hierarchical statistics modeling and human gift for pattern recognition to allow a progressive yet interactive discovery of hidden clusters within high dimensional and complex biomedical datasets. The distinctive features of VISDA are particularly useful for users across the cancer research and broader research communities to analyze complex biological data. AVAILABILITY: http://gforge.nci.nih.gov/projects/visda/ CONTACT: yuewangt.edu Supplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Wang, Jiajing AU - Li, Huai AU - Zhu, Yitan AU - Yousef, Malik AU - Nebozhyn, Michael AU - Showe, Michael AU - Showe, Louise AU - Xuan, Jianhua AU - Clarke, Robert AU - Wang, Yue AD - Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, Bioinformatics Unit, RRB, National Institute on Aging, NIH, Baltimore, MD 21224, Systems Biology Division, The Wistar Institute, Philadelphia, PA 19104 and Lombardi Comprehensive Cancer Center and Department of Oncology, Georgetown University, Washington, DC 20057, USA Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 2024 EP - 2027 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 23 IS - 15 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Pattern recognition KW - Data processing KW - Statistics KW - Bioinformatics KW - Cancer KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19738961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=VISDA%3A+an+open-source+caBIG+super%28TM%29+analytical+tool+for+data+clustering+and+beyond&rft.au=Wang%2C+Jiajing%3BLi%2C+Huai%3BZhu%2C+Yitan%3BYousef%2C+Malik%3BNebozhyn%2C+Michael%3BShowe%2C+Michael%3BShowe%2C+Louise%3BXuan%2C+Jianhua%3BClarke%2C+Robert%3BWang%2C+Yue&rft.aulast=Wang&rft.aufirst=Jiajing&rft.date=2007-08-01&rft.volume=23&rft.issue=15&rft.spage=2024&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Pattern recognition; Statistics; Data processing; Bioinformatics; Cancer ER - TY - JOUR T1 - The Neutrophil-specific Antigen CD177 Is a Counter-receptor for Platelet Endothelial Cell Adhesion Molecule-1 (CD31) AN - 19738672; 7557621 AB - Human neutrophil-specific CD177 (NB1 and PRV-1) has been reported to be up-regulated in a number of inflammatory settings, including bacterial infection and granulocyte-colony-stimulating factor application. Little is known about its function. By flow cytometry and immunoprecipitation studies, we identified platelet endothelial cell adhesion molecule-1 (PECAM-1) as a binding partner of CD177. Real-time protein-protein analysis using surface plasmon resonance confirmed a cation-dependent, specific interaction between CD177 and the heterophilic domains of PECAM-1. Monoclonal antibodies against CD177 and against PECAM-1 domain 6 inhibited adhesion of U937 cells stably expressing CD177 to immobilized PECAM-1. Transendothelial migration of human neutrophils was also inhibited by these antibodies. Our findings provide direct evidence that neutrophil-specific CD177 is a heterophilic binding partner of PECAM-1. This interaction may constitute a new pathway that participates in neutrophil transmigration. JF - Journal of Biological Chemistry AU - Sachs, Ulrich JH AU - Andrei-Selmer, Cornelia L AU - Maniar, Amudhan AU - Weiss, Timo AU - Paddock, Cathy AU - Orlova, Valeria V AU - Choi, Eun Young AU - Newman, Peter J AU - Preissner, Klaus T AU - Chavakis, Triantafyllos AU - Santoso, Sentot AD - Institute for Clinical Immunology and Transfusion Medicine and the Institute for Biochemistry, Justus Liebig University, Langhansstrasse 7, Giessen D-35392, Germany, the Blood Research Institute, Blood Center of Wisconsin, Milwaukee, Wisconsin 53233, and the Experimental Immunology Branch, NCI, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 23603 EP - 23612 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 32 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Leukocyte migration KW - Flow cytometry KW - CD31 antigen KW - surface plasmon resonance KW - Monoclonal antibodies KW - Leukocytes (neutrophilic) KW - Immunoprecipitation KW - Cell migration KW - Infection KW - Inflammation KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19738672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=The+Neutrophil-specific+Antigen+CD177+Is+a+Counter-receptor+for+Platelet+Endothelial+Cell+Adhesion+Molecule-1+%28CD31%29&rft.au=Sachs%2C+Ulrich+JH%3BAndrei-Selmer%2C+Cornelia+L%3BManiar%2C+Amudhan%3BWeiss%2C+Timo%3BPaddock%2C+Cathy%3BOrlova%2C+Valeria+V%3BChoi%2C+Eun+Young%3BNewman%2C+Peter+J%3BPreissner%2C+Klaus+T%3BChavakis%2C+Triantafyllos%3BSantoso%2C+Sentot&rft.aulast=Sachs&rft.aufirst=Ulrich&rft.date=2007-08-01&rft.volume=282&rft.issue=32&rft.spage=23603&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Leukocyte migration; surface plasmon resonance; CD31 antigen; Monoclonal antibodies; Immunoprecipitation; Leukocytes (neutrophilic); Cell migration; Infection; Inflammation ER - TY - JOUR T1 - Cigarette Smoking and Cancer Risk: Modeling Total Exposure and Intensity AN - 19734303; 7554706 AB - A recent analysis showed that the excess odds ratio (EOR) for lung cancer due to smoking can be modeled by a function which is linear in total pack-years and exponential in the logarithm of smoking intensity and its square. Below 15-20 cigarettes per day, the EOR/pack-year increased with intensity (direct exposure rate or enhanced potency effect), suggesting greater risk for a total exposure delivered at higher intensity (for a shorter duration) than for an equivalent exposure delivered at lower intensity. Above 20 cigarettes per day, the EOR/pack-year decreased with increasing intensity (inverse exposure rate or reduced potency effect), suggesting greater risk for a total exposure delivered at lower intensity (for a longer duration) than for an equivalent exposure delivered at higher intensity. The authors applied this model to data from 10 case-control studies of cancer, including cancers of the lung, bladder, oral cavity, pancreas, and esophagus. At lower intensities, there was enhanced potency for several cancer sites, but narrow ranges for pack-years increased uncertainty, precluding definitive conclusions. At higher intensities, there was a consistent reduced potency effect across studies. The intensity effects were statistically homogeneous, indicating that after accounting for risk from total pack-years, intensity patterns were comparable across the diverse cancer sites. JF - American Journal of Epidemiology AU - Lubin, Jay H AU - Alavanja, Michael CR AU - Caporaso, Neil AU - Brown, Linda M AU - Brownson, Ross C AU - Field, RWilliam AU - Garcia-Closas, Montserrat AU - Hartge, Patricia AU - Hauptmann, Michael AU - Hayes, Richard B AU - Kleinerman, Ruth AU - Kogevinas, Manolis AU - Krewski, Daniel AU - Langholz, Bryan AU - Letourneau, Ernest G AU - Lynch, Charles F AU - Malats, Nuria AU - Sandler, Dale P AU - Schaffrath-Rosario, Angelika AU - Schoenberg, Janet B AU - Silverman, Debra T AU - Wang, Zuoyuan AU - Wichmann, H-Erich AU - Wilcox, Homer B AU - Zielinski, Jan M AD - Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 479 EP - 489 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 166 IS - 4 SN - 0002-9262, 0002-9262 KW - Health & Safety Science Abstracts; Risk Abstracts; Toxicology Abstracts KW - Esophagus KW - Urinary bladder KW - Pancreas KW - Cigarette smoking KW - Oral cavity KW - Lung cancer KW - Models KW - X 24380:Social Poisons & Drug Abuse KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19734303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Cigarette+Smoking+and+Cancer+Risk%3A+Modeling+Total+Exposure+and+Intensity&rft.au=Lubin%2C+Jay+H%3BAlavanja%2C+Michael+CR%3BCaporaso%2C+Neil%3BBrown%2C+Linda+M%3BBrownson%2C+Ross+C%3BField%2C+RWilliam%3BGarcia-Closas%2C+Montserrat%3BHartge%2C+Patricia%3BHauptmann%2C+Michael%3BHayes%2C+Richard+B%3BKleinerman%2C+Ruth%3BKogevinas%2C+Manolis%3BKrewski%2C+Daniel%3BLangholz%2C+Bryan%3BLetourneau%2C+Ernest+G%3BLynch%2C+Charles+F%3BMalats%2C+Nuria%3BSandler%2C+Dale+P%3BSchaffrath-Rosario%2C+Angelika%3BSchoenberg%2C+Janet+B%3BSilverman%2C+Debra+T%3BWang%2C+Zuoyuan%3BWichmann%2C+H-Erich%3BWilcox%2C+Homer+B%3BZielinski%2C+Jan+M&rft.aulast=Lubin&rft.aufirst=Jay&rft.date=2007-08-01&rft.volume=166&rft.issue=4&rft.spage=479&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Esophagus; Urinary bladder; Pancreas; Cigarette smoking; Oral cavity; Models; Lung cancer ER - TY - JOUR T1 - Racial Differences in Serum Selenium Concentration: Analysis of US Population Data from the Third National Health and Nutrition Examination Survey AN - 19732936; 7528299 AB - Lower intake of the essential trace element selenium may be a risk factor for prostate cancer and other cancers. In the United States, many racial disparities in cancer incidence, such as the 61% higher incidence of prostate cancer among Blacks relative to Whites, remain unexplained. Using data from a large, nationally representative survey, the authors explored Black/White differences in serum selenium concentration. Mean serum selenium concentrations, both crude and adjusted for known predictors of serum selenium, were determined for 10,779 Black and White males and females aged greater than or equal to 12 years who participated in the Third National Health and Nutrition Examination Survey (1988-1994). Crude mean serum selenium concentrations were 126.35 ng/ml for Whites and 118.76 ng/ml ( similar to 6% lower) for Blacks. Adjustment for known serum selenium predictors, including a proxy for residence at the county level, reduced the racial disparity, although concentrations remained approximately 3% lower in Blacks than in Whites of both sexes (p < 0.0001). The observation that Blacks had lower unadjusted and adjusted serum selenium concentrations relative to Whites is intriguing, given the racial disparity in incidence of prostate cancer and other cancers. JF - American Journal of Epidemiology AU - Vogt, Tara M AU - Ziegler, Regina G AU - Patterson, Blossom H AU - Graubard, Barry I AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD Y1 - 2007/08/01/ PY - 2007 DA - 2007 Aug 01 SP - 280 EP - 288 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 166 IS - 3 SN - 0002-9262, 0002-9262 KW - Toxicology Abstracts KW - Selenium KW - Prostate cancer KW - Risk factors KW - Nutrition KW - Trace elements KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19732936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Racial+Differences+in+Serum+Selenium+Concentration%3A+Analysis+of+US+Population+Data+from+the+Third+National+Health+and+Nutrition+Examination+Survey&rft.au=Vogt%2C+Tara+M%3BZiegler%2C+Regina+G%3BPatterson%2C+Blossom+H%3BGraubard%2C+Barry+I&rft.aulast=Vogt&rft.aufirst=Tara&rft.date=2007-08-01&rft.volume=166&rft.issue=3&rft.spage=280&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Selenium; Prostate cancer; Risk factors; Nutrition; Trace elements ER - TY - JOUR T1 - High-throughput carbohydrate microarray profiling of 27 antibodies demonstrates widespread specificity problems AN - 19489452; 8510491 AB - Progress toward understanding the biological roles of carbohydrates has been remarkably slow, and efforts to exploit this class of biopolymers as diagnostic and therapeutic targets have proven extremely challenging. Both basic and clinical research rely heavily on identifying and monitoring expression levels of carbohydrates. Over the last 30 years, the majority of expression information has been derived from antibody- and lectin-binding studies. Using a carbohydrate microarray containing 80 different glycans and glycoproteins, the specificities of 27 antiglycan antibodies were evaluated, including antibodies to histo-blood group A, B, and H antigens (81FR2.2, CLCP-19B, B389, 92FR-A2, B480, B460, B376, and B393), Lewis antigens (7LE, 15C02, 28, ZC-18C, 121SLE, CA199.02, PR.5C5, 2-25LE, BR55, T174, T218, F3, A70-C/C8, FR4A5, and K21), and other tumor-associated antigens (B389, 1A4, B1.1, and 5B5). In total, evaluation of over 2000 individual carbohydrate-protein interactions was carried out. More than half of the antibodies considered to be specific for their designated antigen were found to cross-react with other glycans. The cross-reactive glycans could be mistaken for the designated antigen in biopsy samples or other biological samples, leading to inaccurate conclusions. JF - Glycobiology AU - Manimala, Joseph C AU - Roach, Timothy A AU - Li, Zhitao AU - Gildersleeve, Jeffrey C AD - Laboratory of Medicinal Chemistry, Center for Cancer Research , National Cancer Institute , 376 Boyles Street, Building 376, Room 109, Frederick, MD 21702, gildersleevej@ncifcrf.gov Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 17C EP - 23C PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 17 IS - 8 SN - 0959-6658, 0959-6658 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - antibodies KW - blood group antigens KW - glycan array KW - Lewis antigens KW - tumor-associated carbohydrate antigens KW - Lewis antigen KW - Antibodies KW - Antigen (tumor-associated) KW - Biopolymers KW - Biopsy KW - Carbohydrates KW - Glycoproteins KW - Polysaccharides KW - H antigen KW - F 06910:Microorganisms & Parasites KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19489452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Glycobiology&rft.atitle=High-throughput+carbohydrate+microarray+profiling+of+27+antibodies+demonstrates+widespread+specificity+problems&rft.au=Manimala%2C+Joseph+C%3BRoach%2C+Timothy+A%3BLi%2C+Zhitao%3BGildersleeve%2C+Jeffrey+C&rft.aulast=Manimala&rft.aufirst=Joseph&rft.date=2007-08-01&rft.volume=17&rft.issue=8&rft.spage=17C&rft.isbn=&rft.btitle=&rft.title=Glycobiology&rft.issn=09596658&rft_id=info:doi/10.1093%2Fglycob%2Fcwm047 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Lewis antigen; Antibodies; Antigen (tumor-associated); Biopolymers; Biopsy; Glycoproteins; Carbohydrates; H antigen; Polysaccharides DO - http://dx.doi.org/10.1093/glycob/cwm047 ER - TY - JOUR T1 - Characterization of mismatch and high-signal intensity probes associated with Affymetrix genechips AN - 17695353; 7609321 AB - MOTIVATION: For Affymetrix microarray platforms, gene expression is determined by computing the difference in signal intensities between perfect match (PM) and mismatch (MM) probesets. Although the use of PM is not controversial, MM probesets have been associated with variance and ultimately inaccurate gene expression calls. A principal focus of this study was to investigate the nature of the MM signal intensities and demonstrate its contribution to the experimental results. RESULTS: While most MM intensities were likely associated with random noise, a subset of similar to 20% (99 485) of the MM probes displayed relatively high signal intensities to the corresponding PM probes (MM > PM) in a non-random fashion; 13 440 of these probes demonstrated exceptionally high 'outlier' intensities. About 15 938 PM probes also demonstrated exceptionally high outlier intensities consistently across all hybridizations. About 92% of the MM > PM probes had either a dThymidine (dT) or a dCytidine (dC) at the 13th position of the probe sequence. MM and PM probes displaying extremely high outlier intensities contained high dC rich nucleotides, and low dA contents at other nucleotides positions along the 25mer probe sequence. Differentially expressed genes generated using Genechip Operating System (GCOS) or modified PM-only methods were also examined. Of those candidate genes identified in the PM-only method, 157 of them were designated by GCOS as absent across all datasets and many others contained probes with MM > PM signal intensities. Our data suggests that MM intensity from PM signal can be a major source of error analysis, leading to fewer potentially biologically important candidate genes. CONTACT: wangyongail.nih.gov Supplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Wang, Yonghong AU - Miao, Ze-Hong AU - Pommier, Yves AU - Kawasaki, Ernest S AU - Player, Audrey AD - SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, Microarray Core Facility, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA and Current address: Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, 201203, P.R. China Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 2088 EP - 2095 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 23 IS - 16 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Vocalization behavior KW - Nucleotide sequence KW - Bioinformatics KW - DNA microarrays KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17695353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Characterization+of+mismatch+and+high-signal+intensity+probes+associated+with+Affymetrix+genechips&rft.au=Wang%2C+Yonghong%3BMiao%2C+Ze-Hong%3BPommier%2C+Yves%3BKawasaki%2C+Ernest+S%3BPlayer%2C+Audrey&rft.aulast=Wang&rft.aufirst=Yonghong&rft.date=2007-08-01&rft.volume=23&rft.issue=16&rft.spage=2088&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gene expression; Vocalization behavior; Nucleotide sequence; Bioinformatics; DNA microarrays ER - TY - JOUR T1 - Computational Design of an RNA Hexagonal Nanoring and an RNA Nanotube AN - 17690232; 7599101 AB - The combination of computer modeling, RNA structure versatility, and siRNA function can be efficiently used to design an all-RNA nanoparticle capable of siRNA delivery. Here, we present a computational design of an RNA nanoring and a nanotube. An RNA nanoring consists of six simple linear building blocks that are assembled together via known noncovalent loop-loop contacts based on RNAI/RNAII inverse sequences. The helical sequences of the building blocks can include siRNAs for drug delivery. JF - Nano Letters AU - Yingling, Y G AU - Shapiro, BA AD - Center for Cancer Research Nanobiology Program, National Cancer Institute, NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702, USA Y1 - 2007/08// PY - 2007 DA - Aug 2007 SP - 2328 EP - 2334 VL - 7 IS - 8 SN - 1530-6984, 1530-6984 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - siRNA KW - RNA-mediated interference KW - Computer applications KW - N 14830:RNA KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17690232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nano+Letters&rft.atitle=Computational+Design+of+an+RNA+Hexagonal+Nanoring+and+an+RNA+Nanotube&rft.au=Yingling%2C+Y+G%3BShapiro%2C+BA&rft.aulast=Yingling&rft.aufirst=Y&rft.date=2007-08-01&rft.volume=7&rft.issue=8&rft.spage=2328&rft.isbn=&rft.btitle=&rft.title=Nano+Letters&rft.issn=15306984&rft_id=info:doi/10.1021%2Fnl070984r LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Drug delivery; siRNA; RNA-mediated interference; Computer applications DO - http://dx.doi.org/10.1021/nl070984r ER - TY - JOUR T1 - Effects of accessory proteins on the bypass of a cis-syn thymine-thymine dimer by Saccharomyces cerevisiae DNA polymerase eta. AN - 70759514; 17608453 AB - Among several hypotheses to explain how translesion synthesis (TLS) by DNA polymerase eta (pol eta) suppresses ultraviolet light-induced mutagenesis in vivo despite the fact that pol eta copies DNA with low fidelity, here we test whether replication accessory proteins enhance the fidelity of TLS by pol eta. We first show that the single-stranded DNA binding protein RPA, the sliding clamp PCNA, and the clamp loader RFC slightly increase the processivity of yeast pol eta and its ability to recycle to new template primers. However, these increases are small, and they are similar when copying an undamaged template and a template containing a cis-syn TT dimer. Consequently, the accessory proteins do not strongly stimulate the already robust TT dimer bypass efficiency of pol eta. We then perform a comprehensive analysis of yeast pol eta fidelity. We show that it is much less accurate than other yeast DNA polymerases and that the accessory proteins have little effect on fidelity when copying undamaged templates or when bypassing a TT dimer. Thus, although accessory proteins clearly participate in pol eta functions in vivo, they do not appear to help suppress UV mutagenesis by improving pol eta bypass fidelity per se. JF - Biochemistry AU - McCulloch, Scott D AU - Wood, Adam AU - Garg, Parie AU - Burgers, Peter M J AU - Kunkel, Thomas A AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/07/31/ PY - 2007 DA - 2007 Jul 31 SP - 8888 EP - 8896 VL - 46 IS - 30 SN - 0006-2960, 0006-2960 KW - Cell Cycle Proteins KW - 0 KW - DNA, Fungal KW - DNA-Binding Proteins KW - Proliferating Cell Nuclear Antigen KW - Pyrimidine Dimers KW - RFC1 protein, S cerevisiae KW - Replication Protein A KW - Replication Protein C KW - Saccharomyces cerevisiae Proteins KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Rad30 protein KW - Index Medicus KW - Ultraviolet Rays KW - DNA Damage KW - Proliferating Cell Nuclear Antigen -- genetics KW - Cell Cycle Proteins -- metabolism KW - Mutagenesis KW - Base Pairing KW - Cell Cycle Proteins -- genetics KW - Replication Protein C -- metabolism KW - Templates, Genetic KW - Replication Protein A -- genetics KW - Replication Protein C -- genetics KW - Replication Protein A -- metabolism KW - DNA Replication KW - Proliferating Cell Nuclear Antigen -- metabolism KW - Saccharomyces cerevisiae -- genetics KW - Saccharomyces cerevisiae Proteins -- metabolism KW - Pyrimidine Dimers -- genetics KW - DNA Repair KW - Saccharomyces cerevisiae Proteins -- genetics KW - Pyrimidine Dimers -- metabolism KW - DNA-Binding Proteins -- genetics KW - DNA, Fungal -- genetics KW - Saccharomyces cerevisiae -- enzymology KW - DNA, Fungal -- metabolism KW - DNA-Directed DNA Polymerase -- genetics KW - DNA-Directed DNA Polymerase -- metabolism KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70759514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Effects+of+accessory+proteins+on+the+bypass+of+a+cis-syn+thymine-thymine+dimer+by+Saccharomyces+cerevisiae+DNA+polymerase+eta.&rft.au=McCulloch%2C+Scott+D%3BWood%2C+Adam%3BGarg%2C+Parie%3BBurgers%2C+Peter+M+J%3BKunkel%2C+Thomas+A&rft.aulast=McCulloch&rft.aufirst=Scott&rft.date=2007-07-31&rft.volume=46&rft.issue=30&rft.spage=8888&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-19 N1 - Date created - 2007-07-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Methods Enzymol. 2006;408:341-55 [16793379] Nucleic Acids Res. 2006;34(16):4335-41 [16936322] Nucleic Acids Res. 2006;34(17):4731-42 [16971464] DNA Repair (Amst). 2006 Nov 8;5(11):1364-72 [16880010] Mutat Res. 1999 Oct 22;435(2):111-9 [10556591] J Biol Chem. 1999 Dec 24;274(52):36835-8 [10601233] J Dermatol Sci. 2000 May;23(1):1-11 [10699759] J Biol Chem. 2000 Mar 17;275(11):7447-50 [10713043] J Biol Chem. 2000 Mar 17;275(11):8233-9 [10713149] Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3094-9 [10725365] Nature. 2000 Apr 27;404(6781):1011-3 [10801132] EMBO J. 2000 Jun 15;19(12):3100-9 [10856253] Mol Cell Biol. 1992 Jan;12(1):155-63 [1346062] J Biol Chem. 1994 Apr 15;269(15):11121-32 [8157639] Methods Enzymol. 1995;262:217-32 [8594349] Mol Cell Biol. 1997 Feb;17(2):760-9 [9001230] J Biol Chem. 1997 Mar 21;272(12):7940-5 [9065463] Genetics. 1997 Dec;147(4):1557-68 [9409821] Mol Gen Genet. 1998 Apr;257(6):686-92 [9604893] Biochemistry. 1998 Sep 8;37(36):12496-506 [9730822] Science. 1999 Feb 12;283(5404):1001-4 [9974380] J Biol Chem. 1999 Jun 11;274(24):16894-900 [10358035] EMBO J. 1999 Jun 15;18(12):3491-501 [10369688] Nature. 1999 Jun 17;399(6737):700-4 [10385124] Mol Cell. 2001 Aug;8(2):417-26 [11545743] J Mol Biol. 2001 Sep 14;312(2):335-46 [11554790] Mol Cell Biol. 2001 Nov;21(21):7199-206 [11585903] Cell. 2001 Oct 5;107(1):91-102 [11595188] Nat Struct Biol. 2001 Nov;8(11):984-9 [11685247] EMBO J. 2001 Dec 17;20(24):7303-12 [11743006] Nucleic Acids Res. 2002 Mar 1;30(5):1262-7 [11861920] Nature. 2002 Sep 12;419(6903):135-41 [12226657] Genetics. 2002 Nov;162(3):1003-18 [12454051] Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):15965-70 [12456887] J Biol Chem. 2003 Jan 17;278(3):1618-25 [12424238] EMBO J. 2003 Mar 3;22(5):1223-33 [12606586] Sci Aging Knowledge Environ. 2003 Feb 26;2003(8):RE3 [12844548] J Invest Dermatol. 2003 Sep;121(3):435-40 [12925197] Nature. 2003 Aug 28;424(6952):1083-7 [12904819] Nature. 2003 Sep 11;425(6954):188-91 [12968183] J Biol Chem. 2003 Oct 31;278(44):43770-80 [12882968] Mol Cell Biol. 2003 Nov;23(22):8316-22 [14585988] J Biol Chem. 2003 Dec 12;278(50):50537-45 [14523013] Nature. 2004 Mar 4;428(6978):97-100 [14999287] Mol Cell. 2004 May 21;14(4):491-500 [15149598] Nucleic Acids Res. 2004;32(15):4665-75 [15333698] EMBO J. 2004 Oct 1;23(19):3886-96 [15359278] Science. 1999 Jul 9;285(5425):263-5 [10398605] Mol Cell Biol. 2005 Feb;25(3):1183-90 [15657443] Genetics. 2005 Feb;169(2):575-82 [15520252] Genetics. 2005 Apr;169(4):1815-24 [15695359] J Biol Chem. 2005 May 20;280(20):20051-8 [15778218] DNA Repair (Amst). 2005 Aug 15;4(9):983-93 [15996534] J Biol Chem. 2000 Dec 15;275(50):39678-84 [11006276] Mol Cell Biol. 2001 Jan;21(1):185-8 [11113193] Philos Trans R Soc Lond B Biol Sci. 2001 Jan 29;356(1405):41-6 [11205328] Genes Dev. 2001 Jan 15;15(2):158-72 [11157773] J Biol Chem. 2001 Jan 26;276(4):2317-20 [11113111] Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8355-60 [11459975] Mol Cell. 2001 Aug;8(2):407-15 [11545742] J Mol Biol. 1968 Jan 28;31(2):291-304 [4865486] Nature. 1976 Jun 17;261(5561):593-5 [934300] Biochem Biophys Res Commun. 1976 Jul 12;71(1):228-34 [962915] Proc Natl Acad Sci U S A. 1989 May;86(9):3085-8 [2524067] Mol Cell Biol. 1989 Oct;9(10):4447-58 [2555694] J Biol Chem. 2005 Aug 19;280(33):29980-7 [15964835] Mol Cell. 2005 Dec 9;20(5):783-92 [16337601] Mol Cell. 2005 Dec 9;20(5):793-9 [16337602] Science. 2005 Dec 16;310(5755):1821-4 [16357261] Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18361-6 [16344468] Mol Cell. 2006 Jan 6;21(1):15-27 [16387650] Cancer Res. 2006 Jan 1;66(1):87-94 [16397220] Curr Biol. 2006 Jan 24;16(2):202-7 [16431373] Nature. 2006 Feb 2;439(7076):557-62 [16452972] Cell Cycle. 2006 May;5(9):958-62 [16687920] Nat Cell Biol. 2006 Jun;8(6):640-2 [16738703] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Efficacy and complication of botulinum toxin injection in palatal myoclonus: experience from a patient. AN - 85400722; pmid-17516476 AB - We report the outcome of botulinum toxin injection for essential palatal myoclonus, given on two occasions over a period of one year, in an eight-year-old boy, the youngest patient treated with botulinum toxin to date. Though there was significant relief of ear clicks each time after the injection, he developed severe palatal palsy following the second injection, which persisted for a month. We suggest that appropriate caution needs to be exercised when repeating botulinum toxin injections for palatal myoclonus in children.Copyright 2007 Movement Disorder Society JF - Movement disorders : official journal of the Movement Disorder Society AU - Pal, Pramod Kumar AU - Lakshmi, Ponnathpur Satish AU - Nirmala, Muninarayanappa AD - Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India. palpramod@hotmail.com Y1 - 2007/07/30/ PY - 2007 DA - 2007 Jul 30 SP - 1484 EP - 1486 VL - 22 IS - 10 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - *Anti-Dyskinesia Agents: therapeutic use KW - *Botulinum Toxins: therapeutic use KW - Child KW - Humans KW - Male KW - *Myoclonus: drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85400722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Efficacy+and+complication+of+botulinum+toxin+injection+in+palatal+myoclonus%3A+experience+from+a+patient.&rft.au=Pal%2C+Pramod+Kumar%3BLakshmi%2C+Ponnathpur+Satish%3BNirmala%2C+Muninarayanappa&rft.aulast=Pal&rft.aufirst=Pramod&rft.date=2007-07-30&rft.volume=22&rft.issue=10&rft.spage=1484&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - CPAPER T1 - Proteomic Analysis of Mitochondrial Proteins in Preconditioned Mouse Myocardium: Effects of Endosomal Trafficking T2 - 4th Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences (BCVS 2007) AN - 39531146; 4681496 JF - 4th Annual Symposium of the American Heart Association Council on Basic Cardiovascular Sciences (BCVS 2007) AU - Wong, Renee P Y1 - 2007/07/30/ PY - 2007 DA - 2007 Jul 30 KW - Myocardium KW - Mitochondria KW - Proteomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39531146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+Symposium+of+the+American+Heart+Association+Council+on+Basic+Cardiovascular+Sciences+%28BCVS+2007%29&rft.atitle=Proteomic+Analysis+of+Mitochondrial+Proteins+in+Preconditioned+Mouse+Myocardium%3A+Effects+of+Endosomal+Trafficking&rft.au=Wong%2C+Renee+P&rft.aulast=Wong&rft.aufirst=Renee&rft.date=2007-07-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+Symposium+of+the+American+Heart+Association+Council+on+Basic+Cardiovascular+Sciences+%28BCVS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/browse_results.aspx?type=ce157f01- d924-4ae1-ac1e-9b54b0714fa1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Blueberry-Enriched Diet Protects Heart from Ischemic Damage T2 - 2007 World Congress on Heart Disease, 13th Annual Scientific Sessions of the International Academy of Cardiology AN - 39388435; 4625655 JF - 2007 World Congress on Heart Disease, 13th Annual Scientific Sessions of the International Academy of Cardiology AU - Ahmet, I AU - Spangler, E AU - Shukitt-Hale, B AU - Joseph, J AU - Ingram, D K AU - Talan, M I Y1 - 2007/07/28/ PY - 2007 DA - 2007 Jul 28 KW - Diets KW - Ischemia KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39388435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+World+Congress+on+Heart+Disease%2C+13th+Annual+Scientific+Sessions+of+the+International+Academy+of+Cardiology&rft.atitle=Blueberry-Enriched+Diet+Protects+Heart+from+Ischemic+Damage&rft.au=Ahmet%2C+I%3BSpangler%2C+E%3BShukitt-Hale%2C+B%3BJoseph%2C+J%3BIngram%2C+D+K%3BTalan%2C+M+I&rft.aulast=Ahmet&rft.aufirst=I&rft.date=2007-07-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+World+Congress+on+Heart+Disease%2C+13th+Annual+Scientific+Sessions+of+the+International+Academy+of+Cardiology&rft.issn=&rft_id=info:doi/ L2 - http://www.cardiologyonline.com/wchd07/Scientific%20Program%20June%205 .pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Response Regulator HrpY of Dickeya Dadantii 3937 Regulates Virulence Genes not Linked to the hrp Cluster T2 - 46th Annual Meeting of the Society of Nematologists and Annual Meeting of the American Phytopathological Society (SON/APS 2007) AN - 39300925; 4617771 JF - 46th Annual Meeting of the Society of Nematologists and Annual Meeting of the American Phytopathological Society (SON/APS 2007) AU - Yap, Mee-Ngan AU - Kim, Hye-Sook AU - Charkowski, Amy Y1 - 2007/07/28/ PY - 2007 DA - 2007 Jul 28 KW - Virulence KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39300925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+Society+of+Nematologists+and+Annual+Meeting+of+the+American+Phytopathological+Society+%28SON%2FAPS+2007%29&rft.atitle=The+Response+Regulator+HrpY+of+Dickeya+Dadantii+3937+Regulates+Virulence+Genes+not+Linked+to+the+hrp+Cluster&rft.au=Yap%2C+Mee-Ngan%3BKim%2C+Hye-Sook%3BCharkowski%2C+Amy&rft.aulast=Yap&rft.aufirst=Mee-Ngan&rft.date=2007-07-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+Society+of+Nematologists+and+Annual+Meeting+of+the+American+Phytopathological+Society+%28SON%2FAPS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nematologists.org/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Replacement of nonmuscle myosin II-B with II-A rescues brain but not cardiac defects in mice. AN - 70744562; 17519229 AB - The purpose of these studies was to learn whether one isoform of nonmuscle myosin II, specifically nonmuscle myosin II-A, could functionally replace a second one, nonmuscle myosin II-B, in mice. To accomplish this, we used homologous recombination to ablate nonmuscle myosin heavy chain (NMHC) II-B by inserting cDNA encoding green fluorescent protein (GFP)-NMHC II-A into the first coding exon of the Myh10 gene, thereby placing GFP-NMHC II-A under control of the endogenous II-B promoter. Similar to B(-)/B(-) mice, most B(a*)/B(a*) mice died late in embryonic development with structural cardiac defects and impaired cytokinesis of the cardiac myocytes. However, unlike B(-)/B(-) mice, 15 B(a*)/B(a*) mice of 172 F2 generation mice survived embryonic lethality but developed a dilated cardiomyopathy as adults. Surprisingly none of the B(a*)/B(a*) mice showed evidence for hydrocephalus that is always found in B(-)/B(-) mice. Rescue of this defect was due to proper localization and function of GFP-NMHC II-A in place of NMHC II-B in a cell-cell adhesion complex in the cells lining the spinal canal. Restoration of the integrity and adhesion of these cells prevents protrusion of the underlying cells into the spinal canal where they block circulation of the cerebral spinal fluid. However, abnormal migration of facial and pontine neurons found in NMHC II-B mutant and ablated mice persisted in B(a*)/B(a*) mice. Thus, although NMHC II-A can substitute for NMHC II-B to maintain integrity of the spinal canal, NMHC II-B plays an isoform-specific role during cytokinesis in cardiac myocytes and in migration of the facial and pontine neurons. JF - The Journal of biological chemistry AU - Bao, Jianjun AU - Ma, Xuefei AU - Liu, Chengyu AU - Adelstein, Robert S AD - Laboratory of Molecular Cardiology and Transgenic Core, NHLBI, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/07/27/ PY - 2007 DA - 2007 Jul 27 SP - 22102 EP - 22111 VL - 282 IS - 30 SN - 0021-9258, 0021-9258 KW - Recombinant Proteins KW - 0 KW - Nonmuscle Myosin Type IIA KW - EC 3.6.1.- KW - Nonmuscle Myosin Type IIB KW - Index Medicus KW - Animals KW - Recombinant Proteins -- metabolism KW - Exons KW - Genes, Reporter KW - Mice KW - Mutagenesis KW - Nonmuscle Myosin Type IIB -- genetics KW - Nonmuscle Myosin Type IIA -- physiology KW - Nonmuscle Myosin Type IIB -- physiology KW - Brain Diseases -- prevention & control KW - Heart Diseases -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70744562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Replacement+of+nonmuscle+myosin+II-B+with+II-A+rescues+brain+but+not+cardiac+defects+in+mice.&rft.au=Bao%2C+Jianjun%3BMa%2C+Xuefei%3BLiu%2C+Chengyu%3BAdelstein%2C+Robert+S&rft.aulast=Bao&rft.aufirst=Jianjun&rft.date=2007-07-27&rft.volume=282&rft.issue=30&rft.spage=22102&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-20 N1 - Date created - 2007-07-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Improved Efficiency and Delivery of IL-15 DNA in Combination with Il-15 Receptor Alpha DNA in Mice and Macaques as Vaccine Adjuvants and for Immunotherapy Deliver a Potent Growth Signal for NK and T cells T2 - 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2007) AN - 39537488; 4672875 JF - 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2007) AU - Bergamaschi, C AU - Jalah, R AU - Rosati, M AU - Valentin, A AU - Kulkarni, V AU - Alicea, C AU - Patel, V AU - Zhang, G.-M. AU - Felber, B AU - Pavlakis, G Y1 - 2007/07/22/ PY - 2007 DA - 2007 Jul 22 KW - Immunotherapy KW - Vaccines KW - Mice KW - Interleukin 15 receptors KW - Lymphocytes T KW - Interleukin 15 KW - Adjuvants KW - Growth KW - Disease control KW - Macaca KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39537488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+IAS+Conference+on+HIV+Pathogenesis%2C+Treatment+and+Prevention+%28IAS+2007%29&rft.atitle=Improved+Efficiency+and+Delivery+of+IL-15+DNA+in+Combination+with+Il-15+Receptor+Alpha+DNA+in+Mice+and+Macaques+as+Vaccine+Adjuvants+and+for+Immunotherapy+Deliver+a+Potent+Growth+Signal+for+NK+and+T+cells&rft.au=Bergamaschi%2C+C%3BJalah%2C+R%3BRosati%2C+M%3BValentin%2C+A%3BKulkarni%2C+V%3BAlicea%2C+C%3BPatel%2C+V%3BZhang%2C+G.-M.%3BFelber%2C+B%3BPavlakis%2C+G&rft.aulast=Bergamaschi&rft.aufirst=C&rft.date=2007-07-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+IAS+Conference+on+HIV+Pathogenesis%2C+Treatment+and+Prevention+%28IAS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ias2007.org/pag/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Long-Range Recombination Gradient in Intersubtype HIV-1 Recombination T2 - 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2007) AN - 39447035; 4672716 JF - 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2007) AU - Chin, M.P.S. AU - Lee, S.-K. AU - Chen, J AU - Nikolaitchik, O A AU - Powell, D AU - Fivash Jr., M.J. AU - Hu, W.-S. Y1 - 2007/07/22/ PY - 2007 DA - 2007 Jul 22 KW - Recombination KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39447035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+IAS+Conference+on+HIV+Pathogenesis%2C+Treatment+and+Prevention+%28IAS+2007%29&rft.atitle=Long-Range+Recombination+Gradient+in+Intersubtype+HIV-1+Recombination&rft.au=Chin%2C+M.P.S.%3BLee%2C+S.-K.%3BChen%2C+J%3BNikolaitchik%2C+O+A%3BPowell%2C+D%3BFivash+Jr.%2C+M.J.%3BHu%2C+W.-S.&rft.aulast=Chin&rft.aufirst=M.P.S.&rft.date=2007-07-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+IAS+Conference+on+HIV+Pathogenesis%2C+Treatment+and+Prevention+%28IAS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ias2007.org/pag/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Explicit Domain Family Hierarchies in the Conserved Domain Database (CDD). T2 - 15th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB/ECCB 2007) AN - 39483785; 4676303 JF - 15th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB/ECCB 2007) AU - Marchler, Gabriele AU - Marchler-Bauer, Aron AU - Anderson, John B AU - Derbyshire, Myra AU - DeWeese-Scott, Carol AU - Chitsaz, Farideh AU - Gonzales, Noreen AU - Gwadz, Marc AU - Hurwitz, David I AU - Jackson, John D AU - Ke, Zhaoxi AU - Krylov, Dmitri AU - Lanczycki, Christopher J AU - Liebert, Cynthia A AU - Liu, Chunlei AU - Lu, Fu AU - Mullokandov, Michael AU - Song, James S AU - Thiessen, Paul A AU - Yamashita, Roxanne A AU - Yin, Jodie J AU - Zhang, Dachuan AU - Bryant, Steve H Y1 - 2007/07/21/ PY - 2007 DA - 2007 Jul 21 KW - Databases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39483785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB%2FECCB+2007%29&rft.atitle=Explicit+Domain+Family+Hierarchies+in+the+Conserved+Domain+Database+%28CDD%29.&rft.au=Marchler%2C+Gabriele%3BMarchler-Bauer%2C+Aron%3BAnderson%2C+John+B%3BDerbyshire%2C+Myra%3BDeWeese-Scott%2C+Carol%3BChitsaz%2C+Farideh%3BGonzales%2C+Noreen%3BGwadz%2C+Marc%3BHurwitz%2C+David+I%3BJackson%2C+John+D%3BKe%2C+Zhaoxi%3BKrylov%2C+Dmitri%3BLanczycki%2C+Christopher+J%3BLiebert%2C+Cynthia+A%3BLiu%2C+Chunlei%3BLu%2C+Fu%3BMullokandov%2C+Michael%3BSong%2C+James+S%3BThiessen%2C+Paul+A%3BYamashita%2C+Roxanne+A%3BYin%2C+Jodie+J%3BZhang%2C+Dachuan%3BBryant%2C+Steve+H&rft.aulast=Marchler&rft.aufirst=Gabriele&rft.date=2007-07-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB%2FECCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/ismbeccb2007/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Single Nucleotide Polymorphism (SNP) Effect on Potential microRNA Targets for Novel Transcripts and SNPs. T2 - 15th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB/ECCB 2007) AN - 39479554; 4676117 JF - 15th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB/ECCB 2007) AU - Barenboim, Maxim AU - Sei, Yoshitasu AU - Chen, Jingshan AU - Lipska, Barbara AU - Weinberger, Daniel R Y1 - 2007/07/21/ PY - 2007 DA - 2007 Jul 21 KW - Single-nucleotide polymorphism KW - MiRNA KW - Nucleotides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39479554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB%2FECCB+2007%29&rft.atitle=Analysis+of+Single+Nucleotide+Polymorphism+%28SNP%29+Effect+on+Potential+microRNA+Targets+for+Novel+Transcripts+and+SNPs.&rft.au=Barenboim%2C+Maxim%3BSei%2C+Yoshitasu%3BChen%2C+Jingshan%3BLipska%2C+Barbara%3BWeinberger%2C+Daniel+R&rft.aulast=Barenboim&rft.aufirst=Maxim&rft.date=2007-07-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB%2FECCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/ismbeccb2007/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clustering Analysis of Retroviral Integration Site Preference. T2 - 15th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB/ECCB 2007) AN - 39455877; 4676019 JF - 15th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB/ECCB 2007) AU - Wu, Xiaolin AU - Munroe, David Y1 - 2007/07/21/ PY - 2007 DA - 2007 Jul 21 KW - Integration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39455877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB%2FECCB+2007%29&rft.atitle=Clustering+Analysis+of+Retroviral+Integration+Site+Preference.&rft.au=Wu%2C+Xiaolin%3BMunroe%2C+David&rft.aulast=Wu&rft.aufirst=Xiaolin&rft.date=2007-07-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB%2FECCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/ismbeccb2007/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Key Processes Underlying Cancer Phenotypes Using Biologic Pathway Analysis. T2 - 15th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB/ECCB 2007) AN - 39449178; 4675668 JF - 15th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB/ECCB 2007) AU - Efroni, Sol Y1 - 2007/07/21/ PY - 2007 DA - 2007 Jul 21 KW - Cancer KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39449178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB%2FECCB+2007%29&rft.atitle=Identification+of+Key+Processes+Underlying+Cancer+Phenotypes+Using+Biologic+Pathway+Analysis.&rft.au=Efroni%2C+Sol&rft.aulast=Efroni&rft.aufirst=Sol&rft.date=2007-07-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+Annual+International+Conference+on+Intelligent+Systems+for+Molecular+Biology+%28ISMB%2FECCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/ismbeccb2007/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural Insight into the Substrate Specificity of DNA Polymerase m T2 - 21st Symposium of the Protein Society AN - 39447420; 4628736 JF - 21st Symposium of the Protein Society AU - Moon, Andrea AU - Garcia-Diaz, Miguel AU - Bebenek, Katarzyna AU - Davis, Bryan AU - Zhong, Xuejun AU - Ramsden, Dale AU - Kunkel, Thomas AU - Pedersen, Lars Y1 - 2007/07/21/ PY - 2007 DA - 2007 Jul 21 KW - DNA-directed DNA polymerase KW - Substrate specificity KW - Specificity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39447420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Symposium+of+the+Protein+Society&rft.atitle=Structural+Insight+into+the+Substrate+Specificity+of+DNA+Polymerase+m&rft.au=Moon%2C+Andrea%3BGarcia-Diaz%2C+Miguel%3BBebenek%2C+Katarzyna%3BDavis%2C+Bryan%3BZhong%2C+Xuejun%3BRamsden%2C+Dale%3BKunkel%2C+Thomas%3BPedersen%2C+Lars&rft.aulast=Moon&rft.aufirst=Andrea&rft.date=2007-07-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Symposium+of+the+Protein+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.proteinsociety.org/symposium21st/documents/Abstract5-30-07F inal.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Solid State NMR Characterization of Cu Binding to Ab(1-40) Amyloid Fibrils T2 - 21st Symposium of the Protein Society AN - 39447047; 4628621 JF - 21st Symposium of the Protein Society AU - Thurber, Kent AU - Tycko, Robert Y1 - 2007/07/21/ PY - 2007 DA - 2007 Jul 21 KW - N.M.R. KW - beta -Amyloid KW - Fibrils KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39447047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Symposium+of+the+Protein+Society&rft.atitle=Solid+State+NMR+Characterization+of+Cu+Binding+to+Ab%281-40%29+Amyloid+Fibrils&rft.au=Thurber%2C+Kent%3BTycko%2C+Robert&rft.aulast=Thurber&rft.aufirst=Kent&rft.date=2007-07-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Symposium+of+the+Protein+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.proteinsociety.org/symposium21st/documents/Abstract5-30-07F inal.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Trafficking Itineraries of Disease Causing PrP Mutants T2 - 21st Symposium of the Protein Society AN - 39429738; 4628346 JF - 21st Symposium of the Protein Society AU - Ashok, Aarthi AU - Hegde, Ramanujan Y1 - 2007/07/21/ PY - 2007 DA - 2007 Jul 21 KW - Mutants KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39429738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Symposium+of+the+Protein+Society&rft.atitle=The+Trafficking+Itineraries+of+Disease+Causing+PrP+Mutants&rft.au=Ashok%2C+Aarthi%3BHegde%2C+Ramanujan&rft.aulast=Ashok&rft.aufirst=Aarthi&rft.date=2007-07-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Symposium+of+the+Protein+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.proteinsociety.org/symposium21st/documents/Abstract5-30-07F inal.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Accuracy of Structure-Based Sequence Alignment of Automatic Methods T2 - 21st Symposium of the Protein Society AN - 39424564; 4628421 JF - 21st Symposium of the Protein Society AU - Kim, Changhoon AU - Lee, Byungkook Y1 - 2007/07/21/ PY - 2007 DA - 2007 Jul 21 KW - Nucleotide sequence KW - Automation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39424564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Symposium+of+the+Protein+Society&rft.atitle=Accuracy+of+Structure-Based+Sequence+Alignment+of+Automatic+Methods&rft.au=Kim%2C+Changhoon%3BLee%2C+Byungkook&rft.aulast=Kim&rft.aufirst=Changhoon&rft.date=2007-07-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Symposium+of+the+Protein+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.proteinsociety.org/symposium21st/documents/Abstract5-30-07F inal.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Metal Ion Bridge Characterizes the Nuclease A-Inhibitor Interaction T2 - 21st Symposium of the Protein Society AN - 39420430; 4628763 JF - 21st Symposium of the Protein Society AU - Ghosh, Mahua AU - Pedersen, Lars AU - London, Robert Y1 - 2007/07/21/ PY - 2007 DA - 2007 Jul 21 KW - Metals KW - Nuclease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39420430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Symposium+of+the+Protein+Society&rft.atitle=A+Metal+Ion+Bridge+Characterizes+the+Nuclease+A-Inhibitor+Interaction&rft.au=Ghosh%2C+Mahua%3BPedersen%2C+Lars%3BLondon%2C+Robert&rft.aulast=Ghosh&rft.aufirst=Mahua&rft.date=2007-07-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Symposium+of+the+Protein+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.proteinsociety.org/symposium21st/documents/Abstract5-30-07F inal.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Trans-Acting Modifiers of Protein Aggregate Dynamics in the Cytosol T2 - 21st Symposium of the Protein Society AN - 39415787; 4628350 JF - 21st Symposium of the Protein Society AU - Chakrabarti, Oishee AU - Rane, Neena AU - Hegde, Ramanujan Y1 - 2007/07/21/ PY - 2007 DA - 2007 Jul 21 KW - Cytosol KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39415787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Symposium+of+the+Protein+Society&rft.atitle=Trans-Acting+Modifiers+of+Protein+Aggregate+Dynamics+in+the+Cytosol&rft.au=Chakrabarti%2C+Oishee%3BRane%2C+Neena%3BHegde%2C+Ramanujan&rft.aulast=Chakrabarti&rft.aufirst=Oishee&rft.date=2007-07-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Symposium+of+the+Protein+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.proteinsociety.org/symposium21st/documents/Abstract5-30-07F inal.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structure and Assembly of the Enterotoxigenic Escherichia coli Surface Pili CFA/I T2 - 21st Symposium of the Protein Society AN - 39410119; 4628746 JF - 21st Symposium of the Protein Society AU - Li, Yong-Fu AU - Poole, Steven AU - Rasulova, Fatima AU - McVeigh, Annette AU - Savarino, Stephen AU - Xia, Di Y1 - 2007/07/21/ PY - 2007 DA - 2007 Jul 21 KW - Pili KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39410119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Symposium+of+the+Protein+Society&rft.atitle=Structure+and+Assembly+of+the+Enterotoxigenic+Escherichia+coli+Surface+Pili+CFA%2FI&rft.au=Li%2C+Yong-Fu%3BPoole%2C+Steven%3BRasulova%2C+Fatima%3BMcVeigh%2C+Annette%3BSavarino%2C+Stephen%3BXia%2C+Di&rft.aulast=Li&rft.aufirst=Yong-Fu&rft.date=2007-07-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Symposium+of+the+Protein+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.proteinsociety.org/symposium21st/documents/Abstract5-30-07F inal.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Substrate Specificity of Mouse b-Carotene 15,15'- and Mouse b-Carotene 9',10'-Monooxygenases. T2 - 21st Symposium of the Protein Society AN - 39404590; 4628433 JF - 21st Symposium of the Protein Society AU - Poliakov, Eugenia AU - Gentleman, Susan AU - Cunnigham, Francis X AU - Von Lintig, Johannes AU - Redmond, Michael T Y1 - 2007/07/21/ PY - 2007 DA - 2007 Jul 21 KW - beta -Carotene KW - Substrate specificity KW - Specificity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39404590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Symposium+of+the+Protein+Society&rft.atitle=Substrate+Specificity+of+Mouse+b-Carotene+15%2C15%27-+and+Mouse+b-Carotene+9%27%2C10%27-Monooxygenases.&rft.au=Poliakov%2C+Eugenia%3BGentleman%2C+Susan%3BCunnigham%2C+Francis+X%3BVon+Lintig%2C+Johannes%3BRedmond%2C+Michael+T&rft.aulast=Poliakov&rft.aufirst=Eugenia&rft.date=2007-07-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Symposium+of+the+Protein+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.proteinsociety.org/symposium21st/documents/Abstract5-30-07F inal.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a Targeting Factor for Post-Translational Membrane Protein Insertion into the ER T2 - 21st Symposium of the Protein Society AN - 39401471; 4628469 JF - 21st Symposium of the Protein Society AU - Stefanovic, Sandra AU - Hegde, Ramanujan Y1 - 2007/07/21/ PY - 2007 DA - 2007 Jul 21 KW - Membrane proteins KW - Post-translation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39401471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Symposium+of+the+Protein+Society&rft.atitle=Identification+of+a+Targeting+Factor+for+Post-Translational+Membrane+Protein+Insertion+into+the+ER&rft.au=Stefanovic%2C+Sandra%3BHegde%2C+Ramanujan&rft.aulast=Stefanovic&rft.aufirst=Sandra&rft.date=2007-07-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Symposium+of+the+Protein+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.proteinsociety.org/symposium21st/documents/Abstract5-30-07F inal.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ClpXP Modulates FtsZ Polymer Dynamics and Assembly through Degradation T2 - 21st Symposium of the Protein Society AN - 39394824; 4628353 JF - 21st Symposium of the Protein Society AU - Camberg, Jodi L AU - Hoskins, Joel R AU - Wickner, Sue Y1 - 2007/07/21/ PY - 2007 DA - 2007 Jul 21 KW - Polymers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39394824?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Symposium+of+the+Protein+Society&rft.atitle=ClpXP+Modulates+FtsZ+Polymer+Dynamics+and+Assembly+through+Degradation&rft.au=Camberg%2C+Jodi+L%3BHoskins%2C+Joel+R%3BWickner%2C+Sue&rft.aulast=Camberg&rft.aufirst=Jodi&rft.date=2007-07-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Symposium+of+the+Protein+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.proteinsociety.org/symposium21st/documents/Abstract5-30-07F inal.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Protein Entry into the ER and the Concept of Pre-Emptive Quality Control T2 - 21st Symposium of the Protein Society AN - 39394779; 4628348 JF - 21st Symposium of the Protein Society AU - Hegde, Ramanujan AU - Kang, Sang-Wook AU - Rane, Neena Y1 - 2007/07/21/ PY - 2007 DA - 2007 Jul 21 KW - Quality control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39394779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Symposium+of+the+Protein+Society&rft.atitle=Regulation+of+Protein+Entry+into+the+ER+and+the+Concept+of+Pre-Emptive+Quality+Control&rft.au=Hegde%2C+Ramanujan%3BKang%2C+Sang-Wook%3BRane%2C+Neena&rft.aulast=Hegde&rft.aufirst=Ramanujan&rft.date=2007-07-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Symposium+of+the+Protein+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.proteinsociety.org/symposium21st/documents/Abstract5-30-07F inal.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of the DnaK System in Regulating ClpB Chaperone Activity T2 - 21st Symposium of the Protein Society AN - 39371897; 4628351 JF - 21st Symposium of the Protein Society AU - Doyle, Shannon AU - Hoskins, Joel AU - Wickner, Sue Y1 - 2007/07/21/ PY - 2007 DA - 2007 Jul 21 KW - Chaperones KW - ClpB protein KW - DnaK protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39371897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Symposium+of+the+Protein+Society&rft.atitle=The+Role+of+the+DnaK+System+in+Regulating+ClpB+Chaperone+Activity&rft.au=Doyle%2C+Shannon%3BHoskins%2C+Joel%3BWickner%2C+Sue&rft.aulast=Doyle&rft.aufirst=Shannon&rft.date=2007-07-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Symposium+of+the+Protein+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.proteinsociety.org/symposium21st/documents/Abstract5-30-07F inal.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Mechanism of Substrate-Specifc Translocational Attenuation in Preemptive Quality Control (pQC) Pathway T2 - 21st Symposium of the Protein Society AN - 39366660; 4628352 JF - 21st Symposium of the Protein Society AU - Kang, Sang-Wook AU - Hegde, Ramanujan S Y1 - 2007/07/21/ PY - 2007 DA - 2007 Jul 21 KW - Quality control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39366660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Symposium+of+the+Protein+Society&rft.atitle=A+Mechanism+of+Substrate-Specifc+Translocational+Attenuation+in+Preemptive+Quality+Control+%28pQC%29+Pathway&rft.au=Kang%2C+Sang-Wook%3BHegde%2C+Ramanujan+S&rft.aulast=Kang&rft.aufirst=Sang-Wook&rft.date=2007-07-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Symposium+of+the+Protein+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.proteinsociety.org/symposium21st/documents/Abstract5-30-07F inal.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - H. Influenzae MutL ATPase has no Burst Phase and Exhibits Negative Cooperativity in ATP Binding in the Presence of the MutH-Hemimethylated DNA Complex T2 - 21st Symposium of the Protein Society AN - 39320784; 4628437 JF - 21st Symposium of the Protein Society AU - Legler, Patricia M AU - Yang, Wei Y1 - 2007/07/21/ PY - 2007 DA - 2007 Jul 21 KW - ATP KW - Adenosinetriphosphatase KW - Cooperativity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39320784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=21st+Symposium+of+the+Protein+Society&rft.atitle=H.+Influenzae+MutL+ATPase+has+no+Burst+Phase+and+Exhibits+Negative+Cooperativity+in+ATP+Binding+in+the+Presence+of+the+MutH-Hemimethylated+DNA+Complex&rft.au=Legler%2C+Patricia+M%3BYang%2C+Wei&rft.aulast=Legler&rft.aufirst=Patricia&rft.date=2007-07-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=21st+Symposium+of+the+Protein+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.proteinsociety.org/symposium21st/documents/Abstract5-30-07F inal.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies. AN - 70756289; 17620608 AB - The severe acute respiratory syndrome coronavirus (SARS-CoV) caused a worldwide epidemic in late 2002/early 2003 and a second outbreak in the winter of 2003/2004 by an independent animal-to-human transmission. The GD03 strain, which was isolated from an index patient of the second outbreak, was reported to resist neutralization by the human monoclonal antibodies (hmAbs) 80R and S3.1, which can potently neutralize isolates from the first outbreak. Here we report that two hmAbs, m396 and S230.15, potently neutralized GD03 and representative isolates from the first SARS outbreak (Urbani, Tor2) and from palm civets (SZ3, SZ16). These antibodies also protected mice challenged with the Urbani or recombinant viruses bearing the GD03 and SZ16 spike (S) glycoproteins. Both antibodies competed with the SARS-CoV receptor, ACE2, for binding to the receptor-binding domain (RBD), suggesting a mechanism of neutralization that involves interference with the SARS-CoV-ACE2 interaction. Two putative hot-spot residues in the RBD (Ile-489 and Tyr-491) were identified within the SARS-CoV spike that likely contribute to most of the m396-binding energy. Residues Ile-489 and Tyr-491 are highly conserved within the SARS-CoV spike, indicating a possible mechanism of the m396 cross-reactivity. Sequence analysis and mutagenesis data show that m396 might neutralize all zoonotic and epidemic SARS-CoV isolates with known sequences, except strains derived from bats. These antibodies exhibit cross-reactivity against isolates from the two SARS outbreaks and palm civets and could have potential applications for diagnosis, prophylaxis, and treatment of SARS-CoV infections. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Zhu, Zhongyu AU - Chakraborti, Samitabh AU - He, Yuxian AU - Roberts, Anjeanette AU - Sheahan, Tim AU - Xiao, Xiaodong AU - Hensley, Lisa E AU - Prabakaran, Ponraj AU - Rockx, Barry AU - Sidorov, Igor A AU - Corti, Davide AU - Vogel, Leatrice AU - Feng, Yang AU - Kim, Jae-Ouk AU - Wang, Lin-Fa AU - Baric, Ralph AU - Lanzavecchia, Antonio AU - Curtis, Kristopher M AU - Nabel, Gary J AU - Subbarao, Kanta AU - Jiang, Shibo AU - Dimitrov, Dimiter S AD - Protein Interactions Group, Center for Cancer Research Nanobiology Program, SAIC-Frederick, Inc., National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD 21702, USA. Y1 - 2007/07/17/ PY - 2007 DA - 2007 Jul 17 SP - 12123 EP - 12128 VL - 104 IS - 29 SN - 0027-8424, 0027-8424 KW - Antibodies, Monoclonal KW - 0 KW - Receptors, Cell Surface KW - Viral Proteins KW - Index Medicus KW - Virus Replication KW - Animals KW - Severe Acute Respiratory Syndrome -- immunology KW - Models, Molecular KW - Humans KW - Disease Models, Animal KW - Virus Internalization KW - Disease Outbreaks KW - Models, Biological KW - Receptors, Cell Surface -- chemistry KW - Cross Reactions KW - Mutagenesis KW - Severe Acute Respiratory Syndrome -- epidemiology KW - Cell Fusion KW - Binding, Competitive KW - Neutralization Tests KW - Viral Proteins -- metabolism KW - Severe Acute Respiratory Syndrome -- virology KW - Protein Structure, Tertiary KW - Nandiniidae -- virology KW - SARS Virus -- isolation & purification KW - SARS Virus -- physiology KW - SARS Virus -- immunology KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70756289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Potent+cross-reactive+neutralization+of+SARS+coronavirus+isolates+by+human+monoclonal+antibodies.&rft.au=Zhu%2C+Zhongyu%3BChakraborti%2C+Samitabh%3BHe%2C+Yuxian%3BRoberts%2C+Anjeanette%3BSheahan%2C+Tim%3BXiao%2C+Xiaodong%3BHensley%2C+Lisa+E%3BPrabakaran%2C+Ponraj%3BRockx%2C+Barry%3BSidorov%2C+Igor+A%3BCorti%2C+Davide%3BVogel%2C+Leatrice%3BFeng%2C+Yang%3BKim%2C+Jae-Ouk%3BWang%2C+Lin-Fa%3BBaric%2C+Ralph%3BLanzavecchia%2C+Antonio%3BCurtis%2C+Kristopher+M%3BNabel%2C+Gary+J%3BSubbarao%2C+Kanta%3BJiang%2C+Shibo%3BDimitrov%2C+Dimiter+S&rft.aulast=Zhu&rft.aufirst=Zhongyu&rft.date=2007-07-17&rft.volume=104&rft.issue=29&rft.spage=12123&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-30 N1 - Date created - 2007-07-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Lancet. 2003 Apr 19;361(9366):1319-25 [12711465] PLoS Med. 2006 Dec;3(12):e525 [17194199] N Engl J Med. 2003 May 15;348(20):1953-66 [12690092] N Engl J Med. 2003 May 15;348(20):1948-51 [12748314] Biochem Biophys Res Commun. 2003 Dec 26;312(4):1159-64 [14651994] Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2536-41 [14983044] J Virol. 2004 Apr;78(7):3572-7 [15016880] Science. 2004 Mar 12;303(5664):1666-9 [14752165] J Virol. 2004 Jun;78(12):6134-42 [15163706] Virology. 2004 Jul 1;324(2):251-6 [15207612] Lancet. 2004 Jun 26;363(9427):2139-41 [15220038] Virology. 2004 Aug 15;326(1):140-9 [15262502] Nat Med. 2004 Aug;10(8):871-5 [15247913] J Clin Virol. 2004 Sep;31(1):66-8 [15288616] J Infect Dis. 2004 Sep 15;190(6):1119-26 [15319862] Biochem Biophys Res Commun. 2004 Nov 12;324(2):773-81 [15474494] Emerg Infect Dis. 2004 Oct;10(10):1774-81 [15504263] Virology. 2004 Dec 5;330(1):8-15 [15527829] J Virol. 2005 Jan;79(1):503-11 [15596843] Clin Microbiol Infect. 2004 Dec;10(12):1062-6 [15606632] J Virol. 2005 Feb;79(3):1635-44 [15650189] J Infect Dis. 2005 Feb 15;191(4):507-14 [15655773] Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):797-801 [15642942] J Virol. 2005 Mar;79(5):2678-88 [15708987] Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2430-5 [15695582] Virology. 2005 Mar 30;334(1):74-82 [15749124] J Immunol. 2005 Apr 15;174(8):4908-15 [15814718] Curr Opin Mol Ther. 2005 Apr;7(2):151-6 [15844623] J Virol. 2005 May;79(10):5900-6 [15857975] Biochem Biophys Res Commun. 2005 Jul 22;333(1):186-93 [15939399] Emerg Infect Dis. 2005 Jul;11(7):1016-20 [16022774] J Virol. 2005 Sep;79(18):11638-46 [16140741] Science. 2005 Sep 16;309(5742):1864-8 [16166518] Virol J. 2005;2:73 [16122388] J Virol. 2005 Dec;79(23):14909-22 [16282490] J Virol. 2006 Jan;80(2):891-9 [16378991] J Infect Dis. 2006 Mar 1;193(5):685-92 [16453264] J Virol. 2006 May;80(9):4211-9 [16611880] J Immunol. 2006 May 15;176(10):6085-92 [16670317] J Biol Chem. 2006 Jun 9;281(23):15829-36 [16597622] Adv Exp Med Biol. 2006;581:547-50 [17037596] N Engl J Med. 2003 May 15;348(20):1967-76 [12690091] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hypoxia enhances the phosphorylation and cytotoxicity of ganciclovir and zidovudine in Kaposi's sarcoma-associated herpesvirus infected cells. AN - 70743887; 17638913 AB - Primary effusion lymphoma (PEL) is a rare B-cell lymphoma caused by Kaposi's sarcoma-associated herpesvirus (KSHV). PEL is poorly responsive to standard cytotoxic chemotherapy and portends a poor survival. Consequently, new effective treatment options are urgently needed. It is known that KSHV encodes two lytic genes, ORF36 (phosphotransferase) and KSHV ORF21 (thymidine kinase), which can phosphorylate ganciclovir and azidothymidine, respectively. Here, we have explored whether these genes can be used as therapeutic targets for PEL. PEL arises in pleural spaces and other effusions that provide a hypoxic environment. Based on Northern blot analysis, exposure of PEL cells to hypoxia up-regulated the expression of both ORF36 and ORF21. Using a newly developed nonradioactive reverse-phase high-performance liquid chromatography/mass spectrometry method to separate and quantify the phosphorylated forms of ganciclovir and azidothymidine, we found that PEL cells exposed to hypoxia produced increased amounts of the toxic triphosphates of these drugs. Moreover, we found that hypoxia increased the cell toxicity of ganciclovir and azidothymidine in PEL cells but had no significant effect on the herpesvirus-negative cell line CA46. These findings may have clinical applicability in the development of effective therapies for PEL or other KSHV-related malignancies. JF - Cancer research AU - Davis, David A AU - Singer, Kathleen E AU - Reynolds, Irene P AU - Haque, Muzammel AU - Yarchoan, Robert AD - HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. dadavis@helix.nih.gov Y1 - 2007/07/15/ PY - 2007 DA - 2007 Jul 15 SP - 7003 EP - 7010 VL - 67 IS - 14 SN - 0008-5472, 0008-5472 KW - Antiviral Agents KW - 0 KW - Zidovudine KW - 4B9XT59T7S KW - Ganciclovir KW - P9G3CKZ4P5 KW - Index Medicus KW - Mass Spectrometry KW - Tumor Cells, Cultured KW - Phosphorylation KW - Dose-Response Relationship, Drug KW - Humans KW - Cell Line, Tumor KW - Chemistry, Pharmaceutical -- methods KW - Chromatography, High Pressure Liquid KW - Sarcoma, Kaposi -- drug therapy KW - Antiviral Agents -- administration & dosage KW - Ganciclovir -- chemistry KW - Ganciclovir -- administration & dosage KW - Hypoxia KW - Herpesviridae -- metabolism KW - Zidovudine -- administration & dosage KW - Sarcoma, Kaposi -- virology KW - Zidovudine -- chemistry KW - Drug Synergism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70743887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Hypoxia+enhances+the+phosphorylation+and+cytotoxicity+of+ganciclovir+and+zidovudine+in+Kaposi%27s+sarcoma-associated+herpesvirus+infected+cells.&rft.au=Davis%2C+David+A%3BSinger%2C+Kathleen+E%3BReynolds%2C+Irene+P%3BHaque%2C+Muzammel%3BYarchoan%2C+Robert&rft.aulast=Davis&rft.aufirst=David&rft.date=2007-07-15&rft.volume=67&rft.issue=14&rft.spage=7003&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-21 N1 - Date created - 2007-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - MFG-E8/lactadherin promotes tumor growth in an angiogenesis-dependent transgenic mouse model of multistage carcinogenesis. AN - 70724160; 17638889 AB - The relevance of angiogenesis in tumor biology and as a therapeutic target is well established. MFG-E8 (also termed lactadherin) and developmental endothelial locus 1 (Del1) constitute a two-gene family of alpha(v)beta(3)/beta(5) ligands that regulate angiogenesis. After detecting MFG-E8 mRNA in murine tumor cell lines, we sought to determine if MFG-E8 influenced tumorigenesis in Rip1-Tag2 transgenic mice, a cancer model in which angiogenesis is critical. MFG-E8 mRNA and protein were increased in angiogenic islets and tumors in Rip1-Tag2 mice compared with normal pancreas. Frequencies of angiogenic islets and tumor burdens were decreased in MFG-E8-deficient Rip1-Tag2 mice compared with those in control Rip1-Tag2 mice. Invasive carcinomas were modestly underrepresented in MFG-E8-deficient mice, but tumor frequencies and survivals were comparable in these two strains. Absence of MFG-E8 also led to decreases in tumor vascular permeability without obvious changes in vascular morphology. Decreased proliferation was noted in angiogenic islets and increases in apoptotic cells were detected in islets and tumors. Compensatory increases in mRNA encoding proangiogenic proteins, including FGF2, in angiogenic islets, and Del1, in angiogenic islets and tumors, were also detected in MFG-E8-deficient mice. MFG-E8 and its homologue Del1 may represent relevant targets in cancer and other diseases in which angiogenesis is prominent. JF - Cancer research AU - Neutzner, Melanie AU - Lopez, Theresa AU - Feng, Xu AU - Bergmann-Leitner, Elke S AU - Leitner, Wolfgang W AU - Udey, Mark C AD - Dermatology Branch and Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/07/15/ PY - 2007 DA - 2007 Jul 15 SP - 6777 EP - 6785 VL - 67 IS - 14 SN - 0008-5472, 0008-5472 KW - Antigens, Surface KW - 0 KW - GTPase-Activating Proteins KW - Mfge8 protein, mouse KW - Milk Proteins KW - RNA, Messenger KW - Ralbp1 protein, mouse KW - Fibroblast Growth Factor 2 KW - 103107-01-3 KW - Index Medicus KW - Fibroblast Growth Factor 2 -- metabolism KW - Animals KW - Apoptosis KW - RNA, Messenger -- metabolism KW - Pancreas -- metabolism KW - GTPase-Activating Proteins -- physiology KW - Mice KW - Mice, Transgenic KW - Cell Proliferation KW - Male KW - Female KW - Mice, Knockout KW - Milk Proteins -- genetics KW - Neovascularization, Pathologic KW - Cell Transformation, Neoplastic KW - Antigens, Surface -- physiology KW - Antigens, Surface -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70724160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=MFG-E8%2Flactadherin+promotes+tumor+growth+in+an+angiogenesis-dependent+transgenic+mouse+model+of+multistage+carcinogenesis.&rft.au=Neutzner%2C+Melanie%3BLopez%2C+Theresa%3BFeng%2C+Xu%3BBergmann-Leitner%2C+Elke+S%3BLeitner%2C+Wolfgang+W%3BUdey%2C+Mark+C&rft.aulast=Neutzner&rft.aufirst=Melanie&rft.date=2007-07-15&rft.volume=67&rft.issue=14&rft.spage=6777&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-21 N1 - Date created - 2007-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A prospective analysis of imatinib-induced c-KIT modulation in ovarian cancer: a phase II clinical study with proteomic profiling. AN - 70665904; 17559139 AB - c-Kit and platelet-derived growth factor receptor (PDGFR) are potential molecular targets in epithelial ovarian cancer (EOC). Imatinib inhibits the kinase domain and subsequent downstream signaling of these receptor tyrosine kinases. The objective of this study was to investigate biochemical and biologic effects of imatinib on EOC. Patients with recurrent EOC who had received no more than 4 prior regimens and who had good end-organ function were eligible. Imatinib was administered orally at a dose of 400 mg twice daily in continuous, 28-day cycles with reassessment imaging studies obtained every other cycle. Tumor core biopsies were obtained prior to and at 4 weeks into therapy; microdissected tumor and stroma were subjected to protein lysate array analysis. Blood samples were obtained monthly for cytokine measurements. Twenty-three patients were enrolled, including 16 patients who received imatinib 600 mg daily because of gastrointestinal (GI) toxicity and fluid accumulation at the starting dose. The median time to disease progression was 2 months (range, 2-14 months). Common grade 3 toxicities included edema/ascites/pleural effusions in 11 patients (48%), GI complaints in 8 patients (35%), fatigue in 3 patients (13%), and grade 2 and 3 cytopenias in 10 patients and 3 patients (43% and 13%), respectively. Increased circulating levels of interleukin 6 were associated with grade >/=2 fluid collection (P = .02). A statistically significant trend was observed between pretreatment phosphorylated-kit levels in microdissected tumor and stroma and GI toxicity (P < .01), between tumor levels of epidermal growth factor receptor (EGFR) and PDGFR with grade of fatigue (P 100 microM). In contrast, prodrugs 7 and 8 significantly decreased carrageenan-induced rat paw edema showing enhanced in vivo anti-inflammatory activities (ID50's=552 and 174 micromol/kg, respectively) relative to those of the parent NSAIDs aspirin (ID50=714 micromol/kg) and ibuprofen (ID50=326 micromol/kg). The rate of porcine liver esterase-mediated *NO release from prodrugs 7-9 (2 mol of *NO/mol of test compound in 0.6-6.5 min) was substantially higher compared to that observed without enzymatic catalysis (about 1 mol of *NO/mol of test compound in 40-48 h). These incubation studies suggest that both *NO and the parent NSAID would be released upon in vivo activation (hydrolysis) by esterases. Data acquired in an in vivo ulcer index (UI) assay showed that NONO-aspirin (UI=0.8), NONO-indomethacin (UI=1.3), and particularly NONO-ibuprofen (UI=0) were significantly less ulcerogenic compared to the parent drugs aspirin (UI=57), ibuprofen (UI=46) or indomethacin (UI=34) at equimolar doses. The release of aspirin and *NO from the NONO-aspirin (7) prodrug constitutes a potentially beneficial property for the prophylactic prevention of thrombus formation and adverse cardiovascular events such as stroke and myocardial infarction. JF - Bioorganic & medicinal chemistry AU - Velázquez, Carlos A AU - Praveen Rao, P N AU - Citro, Michael L AU - Keefer, Larry K AU - Knaus, Edward E AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA. Y1 - 2007/07/15/ PY - 2007 DA - 2007 Jul 15 SP - 4767 EP - 4774 VL - 15 IS - 14 SN - 0968-0896, 0968-0896 KW - Anti-Inflammatory Agents KW - 0 KW - Anti-Inflammatory Agents, Non-Steroidal KW - Cyclooxygenase Inhibitors KW - Oleic Acid KW - 2UMI9U37CP KW - Nitric Oxide KW - 31C4KY9ESH KW - Cyclooxygenase 1 KW - EC 1.14.99.1 KW - Cyclooxygenase 2 KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Molecular Structure KW - Animals KW - Cyclooxygenase 1 -- metabolism KW - Sheep KW - Cyclooxygenase Inhibitors -- chemical synthesis KW - Cyclooxygenase Inhibitors -- chemistry KW - Structure-Activity Relationship KW - Cyclooxygenase Inhibitors -- pharmacology KW - Rats KW - Stomach Ulcer -- drug therapy KW - Anti-Inflammatory Agents -- chemistry KW - Anti-Inflammatory Agents -- chemical synthesis KW - Enzyme Activation -- drug effects KW - Cyclooxygenase 2 -- metabolism KW - Methylation KW - Stomach Ulcer -- pathology KW - Anti-Inflammatory Agents -- pharmacology KW - Anti-Inflammatory Agents, Non-Steroidal -- chemistry KW - Oleic Acid -- therapeutic use KW - Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use KW - Anti-Inflammatory Agents, Non-Steroidal -- chemical synthesis KW - Oleic Acid -- chemical synthesis KW - Oxygen -- chemistry KW - Nitric Oxide -- metabolism KW - Oleic Acid -- pharmacology KW - Nitric Oxide -- chemistry KW - Oleic Acid -- chemistry KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70570896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+%26+medicinal+chemistry&rft.atitle=O2-acetoxymethyl-protected+diazeniumdiolate-based+NSAIDs+%28NONO-NSAIDs%29%3A+synthesis%2C+nitric+oxide+release%2C+and+biological+evaluation+studies.&rft.au=Vel%C3%A1zquez%2C+Carlos+A%3BPraveen+Rao%2C+P+N%3BCitro%2C+Michael+L%3BKeefer%2C+Larry+K%3BKnaus%2C+Edward+E&rft.aulast=Vel%C3%A1zquez&rft.aufirst=Carlos&rft.date=2007-07-15&rft.volume=15&rft.issue=14&rft.spage=4767&rft.isbn=&rft.btitle=&rft.title=Bioorganic+%26+medicinal+chemistry&rft.issn=09680896&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-08 N1 - Date created - 2007-06-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Inflamm Allergy Drug Targets. 2006 Apr;5(2):121-31 [16613571] Eur J Pharmacol. 1994 May 23;257(3):249-55 [8088345] Vnitr Lek. 2006 Jul-Aug;52(7-8):686-90 [16967609] Therapie. 2006 May-Jun;61(3):255-66 [16989128] Am J Epidemiol. 2006 Nov 1;164(9):881-9 [17005625] Int J Cardiol. 2007 Sep 3;120(3):351-6 [17174421] Gastrointest Endosc Clin N Am. 2006 Jan;16(1):83-97 [16546025] J Med Chem. 2000 Jan 27;43(2):261-9 [10649981] Heart. 2001 Mar;85(3):265-71 [11179262] Am J Physiol Gastrointest Liver Physiol. 2002 Nov;283(5):G1090-7 [12381522] Annu Rev Pharmacol Toxicol. 2003;43:585-607 [12415121] Eur J Med Chem. 2003 Apr;38(4):441-6 [12750033] Br J Clin Pharmacol. 2003 Aug;56(2):146-55 [12895187] Can J Gastroenterol. 2004 Apr;18(4):229-36 [15054499] J Pharmacol Exp Ther. 2004 May;309(2):626-33 [14755007] Bioorg Med Chem. 2004 Jul 15;12(14):3831-40 [15210150] Trends Mol Med. 2004 Jul;10(7):324-30 [15242680] Bioorg Med Chem. 2004 Aug 1;12(15):4169-77 [15246093] Aliment Pharmacol Ther. 2004 Jul;20 Suppl 2:48-58 [15335413] Bioorg Med Chem. 2004 Nov 15;12(22):5929-40 [15498669] Cardiovasc Drugs Ther. 1994 Jun;8(3):489-99 [7947366] J Gastroenterol Hepatol. 1994;9 Suppl 1:S40-4 [7881018] Methods Enzymol. 1996;268:281-93 [8782594] Can J Gastroenterol. 1999 Mar;13(2):123-7 [10203430] J Rheumatol Suppl. 1999 Apr;56:18-24 [10225536] Proc Soc Exp Biol Med. 1962 Dec;111:544-7 [14001233] Rev Med Liege. 2004 Oct;59(10):565-9 [15623076] Pharmacol Ther. 2005 Jan;105(1):57-68 [15626455] J Med Chem. 2005 Apr 7;48(7):2251-7 [15801815] J Med Chem. 2005 Jun 16;48(12):4061-7 [15943479] Curr Top Med Chem. 2005;5(5):517-25 [15974946] Am J Gastroenterol. 2005 Aug;100(8):1694-5 [16144121] Drug Saf. 2006;29(2):119-32 [16454539] Postgrad Med J. 2006 Mar;82(965):186-91 [16517800] Scand J Gastroenterol Suppl. 1992;192:3-8 [1439567] BMJ. 1994 Jan 8;308(6921):81-106 [8298418] Drugs R D. 2006;7(4):262-6 [16784252] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cancer risk in women prenatally exposed to diethylstilbestrol. AN - 70537382; 17390375 AB - Prenatal diethylstilbestrol (DES) exposure is associated with excess risks of clear cell adenocarcinoma (CCA), and breast cancer in older women. Whether overall cancer risk is also elevated is unclear. Total and site-specific cancer risks were evaluated in the DES Combined Cohort Follow-up Study using age- and calendar-year specific standardized incidence rate ratios (SIR), and age-adjusted incidence rate ratios (RR) comparing DES exposed and unexposed women. A total of 143 and 49 cancer cases occurred in 97,831 and 34,810 person-years among the exposed and unexposed, respectively. There was no overall excess risk among exposed women when compared with external rates (SIR 1.01; 95% confidence interval [CI] 0.86-1.2). The overall RR comparing exposed with unexposed women was 1.32 (95% CI 0.94-1.8). Breast cancer risk was elevated only among women over 40 years (RR 1.83; 95% CI 1.1-3.2). The CCA SIR among exposed women was nearly 40, and the estimated attack rate through age 39 was 1.6/1,000 women. CCA incidence decreased by over 80% after age 25 when compared with 20-24 years. Excluding CCA and breast cancer, the overall RR was 1.21 (95% CI 0.74-2.0). DES was not associated with excess risks of either endometrial or ovarian cancer. These data suggest that the DES associated increase in CCA incidence remains elevated through the reproductive years. There was no consistent evidence of risk excesses for cancers other than CCA, and breast cancer in older women. Given that the population is still young, continued follow-up is necessary to assess the overall carcinogenic impact of prenatal DES exposure. (c) 2007 Wiley-Liss, Inc. JF - International journal of cancer AU - Troisi, Rebecca AU - Hatch, Elizabeth E AU - Titus-Ernstoff, Linda AU - Hyer, Marianne AU - Palmer, Julie R AU - Robboy, Stanley J AU - Strohsnitter, William C AU - Kaufman, Raymond AU - Herbst, Arthur L AU - Hoover, Robert N AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. troisir@mail.nih.gov Y1 - 2007/07/15/ PY - 2007 DA - 2007 Jul 15 SP - 356 EP - 360 VL - 121 IS - 2 SN - 0020-7136, 0020-7136 KW - Estrogens, Non-Steroidal KW - 0 KW - Diethylstilbestrol KW - 731DCA35BT KW - Index Medicus KW - Regression Analysis KW - Risk Factors KW - Humans KW - Cohort Studies KW - Adult KW - Estrogens, Non-Steroidal -- therapeutic use KW - Incidence KW - Middle Aged KW - Follow-Up Studies KW - Estrogens, Non-Steroidal -- adverse effects KW - United States -- epidemiology KW - Female KW - Pregnancy KW - Diethylstilbestrol -- therapeutic use KW - Diethylstilbestrol -- adverse effects KW - Neoplasms -- chemically induced KW - Neoplasms -- epidemiology KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70537382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Cancer+risk+in+women+prenatally+exposed+to+diethylstilbestrol.&rft.au=Troisi%2C+Rebecca%3BHatch%2C+Elizabeth+E%3BTitus-Ernstoff%2C+Linda%3BHyer%2C+Marianne%3BPalmer%2C+Julie+R%3BRobboy%2C+Stanley+J%3BStrohsnitter%2C+William+C%3BKaufman%2C+Raymond%3BHerbst%2C+Arthur+L%3BHoover%2C+Robert+N&rft.aulast=Troisi&rft.aufirst=Rebecca&rft.date=2007-07-15&rft.volume=121&rft.issue=2&rft.spage=356&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-06 N1 - Date created - 2007-05-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Automated Ligand Fishing Using Human Serum Albumin-Coated Magnetic Beads AN - 20360517; 7646067 AB - Human serum albumin, HSA, was immobilized onto the surface of silica-based magnetic beads. The beads were used to isolate known HSA ligands from a mixture containing ligands and nonligands. The separation was accomplished manually and was also automated. The results indicate that an automated "ligand-fishing" technique can be developed using magnetic beads containing an immobilized protein. JF - Analytical Chemistry (Washington) AU - Moaddel, R AU - Marszall, M P AU - Bighi, F AU - Yang, Q AU - Duan, X AU - Wainer, I W AD - Gerontology Research Center, National Institutes in Aging, National Institutes of Health, Baltimore, Maryland 21224-6825, USA Y1 - 2007/07/15/ PY - 2007 DA - 2007 Jul 15 SP - 5414 EP - 5417 VL - 79 IS - 14 SN - 0003-2700, 0003-2700 KW - Biotechnology and Bioengineering Abstracts KW - human serum albumin KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20360517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Chemistry+%28Washington%29&rft.atitle=Automated+Ligand+Fishing+Using+Human+Serum+Albumin-Coated+Magnetic+Beads&rft.au=Moaddel%2C+R%3BMarszall%2C+M+P%3BBighi%2C+F%3BYang%2C+Q%3BDuan%2C+X%3BWainer%2C+I+W&rft.aulast=Moaddel&rft.aufirst=R&rft.date=2007-07-15&rft.volume=79&rft.issue=14&rft.spage=5414&rft.isbn=&rft.btitle=&rft.title=Analytical+Chemistry+%28Washington%29&rft.issn=00032700&rft_id=info:doi/10.1021%2Fac070268%2B LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - human serum albumin DO - http://dx.doi.org/10.1021/ac070268+ ER - TY - JOUR T1 - Epithelial Cell Proliferation Contributes to Airway Remodeling in Severe Asthma AN - 199600454; 17463414 AB - Despite long-term therapy with corticosteroids, patients with severe asthma develop irreversible airway obstruction. To evaluate if there are structural and functional differences in the airway epithelium in severe asthma associated with airway remodeling. In bronchial biopsies from 21 normal subjects, 11 subjects with chronic bronchitis, 9 subjects with mild asthma, and 31 subjects with severe asthma, we evaluated epithelial cell morphology: epithelial thickness, lamina reticularis (LR) thickness, and epithelial desquamation. Levels of retinoblastoma protein (Rb), Ki67, and Bcl-2 were measured, reflecting cellular proliferation and death. Terminal deoxynucleotidyl-mediated dUTP nick end labeling (TUNEL) was used to study cellular apoptosis. Airway epithelial and LR thickness was greater in subjects with severe asthma compared with those with mild asthma, normal subjects, and diseased control subjects (p=0.009 and 0.033, respectively). There was no significant difference in epithelial desquamation between groups. Active, hypophosphorylated Rb expression was decreased (p=0.002) and Ki67 was increased (p<0.01) in the epithelium of subjects with severe asthma as compared with normal subjects, indicating increased cellular proliferation. Bcl-2 expression was decreased (p<0.001), indicating decreased cell death suppression. There was a greater level of apoptotic activity in the airway biopsy in subjects with severe asthma as compared with the normal subjects using the TUNEL assay (p=0.002), suggesting increased cell death. In subjects with severe asthma, as compared with subjects with mild asthma, normal subjects, and diseased control subjects, we found novel evidence of increased cellular proliferation in the airway contributing to a thickened epithelium and LR. These changes may contribute to the progressive decline in lung function and airway remodeling in patients with severe asthma. JF - American Journal of Respiratory and Critical Care Medicine AU - Cohen, Lance AU - Xueping, E AU - Tarsi, Jaime AU - Ramkumar, Thiruvamoor AU - et al Y1 - 2007/07/15/ PY - 2007 DA - 2007 Jul 15 SP - 138 EP - 45 CY - New York PB - American Thoracic Society VL - 176 IS - 2 SN - 1073449X KW - Medical Sciences--Respiratory Diseases KW - Ki-67 Antigen KW - Proto-Oncogene Proteins c-bcl-2 KW - Retinoblastoma Protein KW - Severity of Illness Index KW - Humans KW - Ki-67 Antigen -- metabolism KW - Aged KW - Asthma -- metabolism KW - Respiratory Mucosa -- metabolism KW - Adult KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Retinoblastoma Protein -- metabolism KW - Case-Control Studies KW - Middle Aged KW - Bronchi -- metabolism KW - Female KW - Male KW - Epithelial Cells -- physiology KW - Cell Proliferation KW - Bronchi -- pathology KW - Respiratory Mucosa -- pathology KW - Asthma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/199600454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Epithelial+Cell+Proliferation+Contributes+to+Airway+Remodeling+in+Severe+Asthma&rft.au=Cohen%2C+Lance%3BXueping%2C+E%3BTarsi%2C+Jaime%3BRamkumar%2C+Thiruvamoor%3Bet+al&rft.aulast=Cohen&rft.aufirst=Lance&rft.date=2007-07-15&rft.volume=176&rft.issue=2&rft.spage=138&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Thoracic Society Jul 15, 2007 N1 - Last updated - 2017-01-07 ER - TY - CPAPER T1 - Association of Honeycomb Lattice Scaffold of Spherical Immature Vaccinia Virus with Membrane Proteins T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39619197; 4677347 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Bisht, Himani AU - Szajner, Patricia AU - Moss, Bernard Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Membrane proteins KW - Scaffolds KW - Honeycombs KW - Vaccinia virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39619197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Association+of+Honeycomb+Lattice+Scaffold+of+Spherical+Immature+Vaccinia+Virus+with+Membrane+Proteins&rft.au=Bisht%2C+Himani%3BSzajner%2C+Patricia%3BMoss%2C+Bernard&rft.aulast=Bisht&rft.aufirst=Himani&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Complete Protection Against Homologous and Heterologous Virus Challenge Induced by Inactivated H5N1 Vaccine Adjuvanted with MF59 and CpG T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39603991; 4677595 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Gillim-Ross, Laura AU - Santos, Celia AU - Wack, Andreas AU - O'Hagan, Derek AU - Subbarao, Kanta Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Vaccines KW - CpG islands KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39603991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Complete+Protection+Against+Homologous+and+Heterologous+Virus+Challenge+Induced+by+Inactivated+H5N1+Vaccine+Adjuvanted+with+MF59+and+CpG&rft.au=Gillim-Ross%2C+Laura%3BSantos%2C+Celia%3BWack%2C+Andreas%3BO%27Hagan%2C+Derek%3BSubbarao%2C+Kanta&rft.aulast=Gillim-Ross&rft.aufirst=Laura&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of Mink Calicivirus, a Proposed New Species in the Genus Vesivirus of the Caliciviridae T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39603654; 4677517 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Rhodes, Crystal R AU - Brooks, Eric M AU - Barron, Elyssa L AU - Bok, Karin AU - Mitra, Tanaji AU - Saif, Linda J AU - Guo, Mingzhang AU - Evermann, James F AU - Sosnovtsev, Stanislav V AU - Green, Kim Y Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - New species KW - Taxonomy KW - Vesivirus KW - Caliciviridae KW - Mink calicivirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39603654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Characterization+of+Mink+Calicivirus%2C+a+Proposed+New+Species+in+the+Genus+Vesivirus+of+the+Caliciviridae&rft.au=Rhodes%2C+Crystal+R%3BBrooks%2C+Eric+M%3BBarron%2C+Elyssa+L%3BBok%2C+Karin%3BMitra%2C+Tanaji%3BSaif%2C+Linda+J%3BGuo%2C+Mingzhang%3BEvermann%2C+James+F%3BSosnovtsev%2C+Stanislav+V%3BGreen%2C+Kim+Y&rft.aulast=Rhodes&rft.aufirst=Crystal&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Predicted Architecture of the Group C Rotavirus RNA-Dependent RNA Polymerase T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39602372; 4678076 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Bar-Magen, Tamara AU - Mascayano, Carolina AU - Gonzalez-Nilo, Fernando AU - Patton, John T Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - RNA-directed RNA polymerase KW - DNA-directed RNA polymerase KW - Group c rotavirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39602372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Predicted+Architecture+of+the+Group+C+Rotavirus+RNA-Dependent+RNA+Polymerase&rft.au=Bar-Magen%2C+Tamara%3BMascayano%2C+Carolina%3BGonzalez-Nilo%2C+Fernando%3BPatton%2C+John+T&rft.aulast=Bar-Magen&rft.aufirst=Tamara&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rapid and Efficient Protection Against Monkeypox Virus by MVA or Dryvax in a Non-Human Primate Model T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39602100; 4678050 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Earl, Patricia AU - Americo, Jeffrey AU - Spano, Yvette Edghill AU - Silvera, Peter AU - Moss, Bernard Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Primates KW - Monkeypox KW - Monkeypox virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39602100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Rapid+and+Efficient+Protection+Against+Monkeypox+Virus+by+MVA+or+Dryvax+in+a+Non-Human+Primate+Model&rft.au=Earl%2C+Patricia%3BAmerico%2C+Jeffrey%3BSpano%2C+Yvette+Edghill%3BSilvera%2C+Peter%3BMoss%2C+Bernard&rft.aulast=Earl&rft.aufirst=Patricia&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Replication and Immunogenicity of H6 Avian Influenza Viruses in Mice and Ferrets T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39601585; 4677920 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Santos, Celia P AU - Gillin-Ross, Laura AU - Jin, Hong AU - Chen, Zhongying AU - Aspelund, Amy AU - Yang, Chin-Fen AU - Kemble, George AU - Subbarao, Kanta Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Mice KW - Influenza KW - Viruses KW - Replication KW - Fowl plague KW - Immunogenicity KW - Mustela KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39601585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Replication+and+Immunogenicity+of+H6+Avian+Influenza+Viruses+in+Mice+and+Ferrets&rft.au=Santos%2C+Celia+P%3BGillin-Ross%2C+Laura%3BJin%2C+Hong%3BChen%2C+Zhongying%3BAspelund%2C+Amy%3BYang%2C+Chin-Fen%3BKemble%2C+George%3BSubbarao%2C+Kanta&rft.aulast=Santos&rft.aufirst=Celia&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Poliovirus Infection Modifies Early Steps of Cellular Secretory Pathway T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39534916; 4677637 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Belov, George A AU - Altan-Bonnet, Nihal AU - Kovtunovych, Gennadiy AU - Habbersett, Courtney A AU - Ehrenfeld, Ellie Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Infection KW - Poliovirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39534916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Poliovirus+Infection+Modifies+Early+Steps+of+Cellular+Secretory+Pathway&rft.au=Belov%2C+George+A%3BAltan-Bonnet%2C+Nihal%3BKovtunovych%2C+Gennadiy%3BHabbersett%2C+Courtney+A%3BEhrenfeld%2C+Ellie&rft.aulast=Belov&rft.aufirst=George&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Live Attenuated SARS Coronavirus is Immunogenic and Protects Golden Syrian Hamsters from Subsequent Challenge T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39534536; 4677572 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Lamirande, Elaine W AU - DeDiego, Marta L AU - Roberts, Anjeanette AU - Alvarez, Enrique AU - Sheahan, Tim AU - Shieh, Wun-Ju AU - Zaki, Sherif R AU - Baric, Ralph AU - Enjuanes, Luis AU - Subbarao, Kanta Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Vaccines KW - Pathogens KW - RNA KW - Disease control KW - SARS coronavirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39534536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=A+Live+Attenuated+SARS+Coronavirus+is+Immunogenic+and+Protects+Golden+Syrian+Hamsters+from+Subsequent+Challenge&rft.au=Lamirande%2C+Elaine+W%3BDeDiego%2C+Marta+L%3BRoberts%2C+Anjeanette%3BAlvarez%2C+Enrique%3BSheahan%2C+Tim%3BShieh%2C+Wun-Ju%3BZaki%2C+Sherif+R%3BBaric%2C+Ralph%3BEnjuanes%2C+Luis%3BSubbarao%2C+Kanta&rft.aulast=Lamirande&rft.aufirst=Elaine&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modulation of Host Cell Gene Expression during Onset of B19 Infection is Focused on Cell Architecture, Cell-Cycle Regulation and Calcium Signaling T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39517582; 4677211 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Zhi, Ning AU - Wong, Susan AU - Billings, Eric AU - Kajigaya, Sachiko AU - Brown, Kevin E AU - Young, Neal S Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Infection KW - Calcium signalling KW - Gene expression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39517582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Modulation+of+Host+Cell+Gene+Expression+during+Onset+of+B19+Infection+is+Focused+on+Cell+Architecture%2C+Cell-Cycle+Regulation+and+Calcium+Signaling&rft.au=Zhi%2C+Ning%3BWong%2C+Susan%3BBillings%2C+Eric%3BKajigaya%2C+Sachiko%3BBrown%2C+Kevin+E%3BYoung%2C+Neal+S&rft.aulast=Zhi&rft.aufirst=Ning&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Vaccinia Virus D10 Protein Possesses mRNA Decapping Activity, Providing a Mechanism to Control Cellular and Viral Gene Expression T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39515916; 4677343 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Parrish, Susan AU - Moss, Bernard Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Gene expression KW - Vaccinia virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39515916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=The+Vaccinia+Virus+D10+Protein+Possesses+mRNA+Decapping+Activity%2C+Providing+a+Mechanism+to+Control+Cellular+and+Viral+Gene+Expression&rft.au=Parrish%2C+Susan%3BMoss%2C+Bernard&rft.aulast=Parrish&rft.aufirst=Susan&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Analysis of the Complete Genome Sequences of Ten Representative G-type Group a Human Rotavirus Strains T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39505451; 4678078 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Heiman, Erica M AU - McDonald, Sarah M AU - Taraporewala, Zenobia F AU - Bar-Magen, Tamara AU - Barro, Mario AU - Patton, John T Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Genomes KW - Strains KW - Human rotavirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39505451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Comparative+Analysis+of+the+Complete+Genome+Sequences+of+Ten+Representative+G-type+Group+a+Human+Rotavirus+Strains&rft.au=Heiman%2C+Erica+M%3BMcDonald%2C+Sarah+M%3BTaraporewala%2C+Zenobia+F%3BBar-Magen%2C+Tamara%3BBarro%2C+Mario%3BPatton%2C+John+T&rft.aulast=Heiman&rft.aufirst=Erica&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Generation and Evaluation of a Live Attenuated Cold Adapted Influenza a H7N3 Vaccine Virus T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39504539; 4677596 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Joseph, Tomy AU - McAuliffe, Josephine AU - Lu, Bin AU - Jin, Hong AU - Swayne, David AU - Kemble, George AU - Subbarao, Kanta Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Vaccines KW - Influenza KW - Influenza A KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39504539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Generation+and+Evaluation+of+a+Live+Attenuated+Cold+Adapted+Influenza+a+H7N3+Vaccine+Virus&rft.au=Joseph%2C+Tomy%3BMcAuliffe%2C+Josephine%3BLu%2C+Bin%3BJin%2C+Hong%3BSwayne%2C+David%3BKemble%2C+George%3BSubbarao%2C+Kanta&rft.aulast=Joseph&rft.aufirst=Tomy&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clinical Evaluation of Dengue Virus Live Attenuated Monovalent Vaccine Candidates T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39504422; 4677576 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Whitehead, Stephen S AU - McArthur, Julie H AU - Marron, Jennifer A AU - Thumar, Bhavin AU - Wanionek, Kimberli A AU - Lovchik, Janece M AU - Blaney, Joseph E AU - Murphy, Brian R AU - Durbin, Anna P Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Vaccines KW - Dengue KW - Disease control KW - Dengue virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39504422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Clinical+Evaluation+of+Dengue+Virus+Live+Attenuated+Monovalent+Vaccine+Candidates&rft.au=Whitehead%2C+Stephen+S%3BMcArthur%2C+Julie+H%3BMarron%2C+Jennifer+A%3BThumar%2C+Bhavin%3BWanionek%2C+Kimberli+A%3BLovchik%2C+Janece+M%3BBlaney%2C+Joseph+E%3BMurphy%2C+Brian+R%3BDurbin%2C+Anna+P&rft.aulast=Whitehead&rft.aufirst=Stephen&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gangliosides are Essential for Bovine Adeno-Associated Virus Entry T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39504018; 4677660 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Chiorini, John A AU - Schmidt, Michael Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Gangliosides KW - Bovine adeno-associated virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39504018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Gangliosides+are+Essential+for+Bovine+Adeno-Associated+Virus+Entry&rft.au=Chiorini%2C+John+A%3BSchmidt%2C+Michael&rft.aulast=Chiorini&rft.aufirst=John&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Epitope Determinants of a Chimpanzee Dengue Type 4 Virus (DENV-4)-Neutralizing Antibody and Demonstration of Protection Against DENV-4 Challenge in Mice and Rhesus Monkeys by Passively Transferred Humanized Antibody T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39503774; 4677609 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Lai, Ching-Juh AU - Men, Ruhe AU - Goncalvez, Ana P AU - Donau, Olivia AU - Engle, Donald E AU - Purcell, Robert H Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Mice KW - Dengue KW - Antibodies KW - Epitopes KW - Pan troglodytes KW - Macaca mulatta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39503774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Epitope+Determinants+of+a+Chimpanzee+Dengue+Type+4+Virus+%28DENV-4%29-Neutralizing+Antibody+and+Demonstration+of+Protection+Against+DENV-4+Challenge+in+Mice+and+Rhesus+Monkeys+by+Passively+Transferred+Humanized+Antibody&rft.au=Lai%2C+Ching-Juh%3BMen%2C+Ruhe%3BGoncalvez%2C+Ana+P%3BDonau%2C+Olivia%3BEngle%2C+Donald+E%3BPurcell%2C+Robert+H&rft.aulast=Lai&rft.aufirst=Ching-Juh&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Inactivated Whole Virion Vaccine is Immunogenic and Protects Hamsters from Infection with the SARS Coronavirus T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39503706; 4677573 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Vogel, L N AU - Roberts, A AU - Lamirande, E W AU - Chen, J AU - Ward, J M AU - Baras, B AU - Vassilev, V AU - Subbarao, K Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Infection KW - Vaccines KW - Virions KW - Disease control KW - SARS coronavirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39503706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=An+Inactivated+Whole+Virion+Vaccine+is+Immunogenic+and+Protects+Hamsters+from+Infection+with+the+SARS+Coronavirus&rft.au=Vogel%2C+L+N%3BRoberts%2C+A%3BLamirande%2C+E+W%3BChen%2C+J%3BWard%2C+J+M%3BBaras%2C+B%3BVassilev%2C+V%3BSubbarao%2C+K&rft.aulast=Vogel&rft.aufirst=L&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Hepatitis C Virus Replication and Interferon Response by Heat Shock Proteins T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39503028; 4677430 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Huang, Ying AU - Liang, T Jake Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Hepatitis KW - Replication KW - Interferon KW - Heat shock proteins KW - Hepatitis C virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39503028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Regulation+of+Hepatitis+C+Virus+Replication+and+Interferon+Response+by+Heat+Shock+Proteins&rft.au=Huang%2C+Ying%3BLiang%2C+T+Jake&rft.aulast=Huang&rft.aufirst=Ying&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mutations in the 3' Genomic Promoter and L Protein of Human Parainfluenza Virus Type 2 Yield Live Attenuated Vaccine Candidates T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39502578; 4677926 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Schaap-Nutt, Anne AU - Skiadopoulos, Mario H AU - Bradley, Konrad AU - Kim, Olivia S AU - Bier, Stacia AU - Amaro-Carambot, Emerito AU - Surman, Sonja R AU - Davis, Stephanie AU - Collins, Peter L AU - Murphy, Brian R AU - Nolan, Sheila M Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Vaccines KW - Mutation KW - Promoters KW - Genomics KW - Parainfluenza KW - L protein KW - Disease control KW - Parainfluenza virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39502578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Mutations+in+the+3%27+Genomic+Promoter+and+L+Protein+of+Human+Parainfluenza+Virus+Type+2+Yield+Live+Attenuated+Vaccine+Candidates&rft.au=Schaap-Nutt%2C+Anne%3BSkiadopoulos%2C+Mario+H%3BBradley%2C+Konrad%3BKim%2C+Olivia+S%3BBier%2C+Stacia%3BAmaro-Carambot%2C+Emerito%3BSurman%2C+Sonja+R%3BDavis%2C+Stephanie%3BCollins%2C+Peter+L%3BMurphy%2C+Brian+R%3BNolan%2C+Sheila+M&rft.aulast=Schaap-Nutt&rft.aufirst=Anne&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a Subgroup-Specific Insertion Located in the RNA Polymerase- Interactive Domain of the Rotavirus Core Lattice Protein VP2 T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39502577; 4678077 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - McDonald, Sarah M AU - Patton, John T Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - RNA KW - Cores KW - Rotavirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39502577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Identification+of+a+Subgroup-Specific+Insertion+Located+in+the+RNA+Polymerase-+Interactive+Domain+of+the+Rotavirus+Core+Lattice+Protein+VP2&rft.au=McDonald%2C+Sarah+M%3BPatton%2C+John+T&rft.aulast=McDonald&rft.aufirst=Sarah&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rotavirus Innate Immune Antagonist NSP1 Targets the Carboxy Terminus of Several Interferon Regulatory Factors T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39502365; 4678012 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Barro, Mario AU - Patton, John T Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Immunity KW - Rotavirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39502365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Rotavirus+Innate+Immune+Antagonist+NSP1+Targets+the+Carboxy+Terminus+of+Several+Interferon+Regulatory+Factors&rft.au=Barro%2C+Mario%3BPatton%2C+John+T&rft.aulast=Barro&rft.aufirst=Mario&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Attenuation and Efficacy of Human Parainfluenza Virus Type 1 (HPIV1) Vaccine Candidates Containing Stabilized Mutations in the P/C and L Genes. T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39502073; 4677927 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Bartlett, Emmalene J AU - Castano, Adam AU - Surman, Sonja R AU - Collins, Peter L AU - Skiadopoulos, Mario H AU - Murphy, Brian R Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Mutation KW - Vaccines KW - Parainfluenza KW - Disease control KW - Parainfluenza virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39502073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Attenuation+and+Efficacy+of+Human+Parainfluenza+Virus+Type+1+%28HPIV1%29+Vaccine+Candidates+Containing+Stabilized+Mutations+in+the+P%2FC+and+L+Genes.&rft.au=Bartlett%2C+Emmalene+J%3BCastano%2C+Adam%3BSurman%2C+Sonja+R%3BCollins%2C+Peter+L%3BSkiadopoulos%2C+Mario+H%3BMurphy%2C+Brian+R&rft.aulast=Bartlett&rft.aufirst=Emmalene&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunization of Primates with a Newcastle Disease Virus-Vectored Vaccine via the Respiratory Tract Induces High Titer Serum Neutralizing Antibodies Against Avian Influenza Virus T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39502045; 4677917 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - DiNapoli, Joshua M AU - Yang, Lijuan AU - Suguitan Jr, Amorsolo AU - Elankumaran, Subbiah AU - Murphy, Brian R AU - Samal, Siba AU - Collins, Peter L AU - Bukreyev, Alexander Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Australia, New South Wales, Newcastle KW - Vaccines KW - Immunization KW - Respiratory tract KW - Influenza KW - Primates KW - Antibodies KW - Fowl plague KW - Newcastle disease KW - Respiration KW - Metabolism KW - Serum KW - Avian physiology KW - Disease control KW - Avian influenza virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39502045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Immunization+of+Primates+with+a+Newcastle+Disease+Virus-Vectored+Vaccine+via+the+Respiratory+Tract+Induces+High+Titer+Serum+Neutralizing+Antibodies+Against+Avian+Influenza+Virus&rft.au=DiNapoli%2C+Joshua+M%3BYang%2C+Lijuan%3BSuguitan+Jr%2C+Amorsolo%3BElankumaran%2C+Subbiah%3BMurphy%2C+Brian+R%3BSamal%2C+Siba%3BCollins%2C+Peter+L%3BBukreyev%2C+Alexander&rft.aulast=DiNapoli&rft.aufirst=Joshua&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV-1 Infection in the Absence of LEM Domain Proteins Emerin and Lap2a T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39501834; 4677242 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Mulky, Alok AU - Cohen, Tatiana AU - Kozlov, Serguei V AU - Foisner, Roland AU - Stewart, Colin L AU - KewalRamani, Vineet N Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Infection KW - Human immunodeficiency virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39501834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=HIV-1+Infection+in+the+Absence+of+LEM+Domain+Proteins+Emerin+and+Lap2a&rft.au=Mulky%2C+Alok%3BCohen%2C+Tatiana%3BKozlov%2C+Serguei+V%3BFoisner%2C+Roland%3BStewart%2C+Colin+L%3BKewalRamani%2C+Vineet+N&rft.aulast=Mulky&rft.aufirst=Alok&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interferon (IFN) Alpha, Beta and Gamma-dependent Signaling are not Required for SARS-CoV-associated Disease in STAT1 Knockout Mice T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39495871; 4677221 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Chen, Jun AU - Lamirande, Elaine W AU - Roberts, Anjeanette AU - Vogel, Leatrice N AU - Anaya, Juan AU - Ward, Jerrold M AU - Subbarao, Kanta Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Mice KW - Signal transduction KW - A-Interferon KW - Interferon KW - B-Interferon KW - Stat1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39495871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Interferon+%28IFN%29+Alpha%2C+Beta+and+Gamma-dependent+Signaling+are+not+Required+for+SARS-CoV-associated+Disease+in+STAT1+Knockout+Mice&rft.au=Chen%2C+Jun%3BLamirande%2C+Elaine+W%3BRoberts%2C+Anjeanette%3BVogel%2C+Leatrice+N%3BAnaya%2C+Juan%3BWard%2C+Jerrold+M%3BSubbarao%2C+Kanta&rft.aulast=Chen&rft.aufirst=Jun&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Characterization of Murine Norovirus Strains from Asymptomatic Mice T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39489576; 4677518 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Barron, Elyssa L AU - Ward, Jerrold M AU - Perdue, Kathy A AU - Copeland, Michelle K AU - Prikhodko, Victor AU - Rhodes, Crystal R AU - Bok, Karin AU - Sosnovtsev, Stanislav V AU - Green, Kim Y Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Mice KW - Strains KW - Norovirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39489576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Genetic+Characterization+of+Murine+Norovirus+Strains+from+Asymptomatic+Mice&rft.au=Barron%2C+Elyssa+L%3BWard%2C+Jerrold+M%3BPerdue%2C+Kathy+A%3BCopeland%2C+Michelle+K%3BPrikhodko%2C+Victor%3BRhodes%2C+Crystal+R%3BBok%2C+Karin%3BSosnovtsev%2C+Stanislav+V%3BGreen%2C+Kim+Y&rft.aulast=Barron&rft.aufirst=Elyssa&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vaccinia Virus A43R Gene Product is a Late N-glycosylated Protein that Localizes in the Golgi Complex and Contributes to Virulence T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39487926; 4677853 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Turcotte, Cindy L AU - Moss, Bernard Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Virulence KW - Golgi apparatus KW - Gene products KW - Vaccinia virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39487926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Vaccinia+Virus+A43R+Gene+Product+is+a+Late+N-glycosylated+Protein+that+Localizes+in+the+Golgi+Complex+and+Contributes+to+Virulence&rft.au=Turcotte%2C+Cindy+L%3BMoss%2C+Bernard&rft.aulast=Turcotte&rft.aufirst=Cindy&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of the Cellular Heterodimer G3BP/p137 in Vaccinia Virus Intermediate Stage Transcription T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39486203; 4677342 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Katsafanas, George C AU - Moss, Bernard Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Transcription KW - Vaccinia virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39486203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Role+of+the+Cellular+Heterodimer+G3BP%2Fp137+in+Vaccinia+Virus+Intermediate+Stage+Transcription&rft.au=Katsafanas%2C+George+C%3BMoss%2C+Bernard&rft.aulast=Katsafanas&rft.aufirst=George&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Improved Method for Detecting B19 Neutralizing Antibodies T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39485756; 4677212 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Wong, Susan AU - Zhi, Ning AU - Young, Neal S Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Antibodies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39485756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=An+Improved+Method+for+Detecting+B19+Neutralizing+Antibodies&rft.au=Wong%2C+Susan%3BZhi%2C+Ning%3BYoung%2C+Neal+S&rft.aulast=Wong&rft.aufirst=Susan&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enhancement of Dengue Virus Infection In Vitro and in Rhesus Monkeys Mediated by a Cross-Reactive Humanized Antibody that Recognizes the Flavivirus-Conserved Fusion Peptide in the Envelope Protein (E) T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39484545; 4677612 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Goncalvez, Ana P AU - Engle, Ronald E AU - Purcell, Robert H AU - Lai, Ching-Juh Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Infection KW - Dengue KW - Antibodies KW - Envelope protein KW - Peptides KW - Macaca mulatta KW - Dengue virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39484545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Enhancement+of+Dengue+Virus+Infection+In+Vitro+and+in+Rhesus+Monkeys+Mediated+by+a+Cross-Reactive+Humanized+Antibody+that+Recognizes+the+Flavivirus-Conserved+Fusion+Peptide+in+the+Envelope+Protein+%28E%29&rft.au=Goncalvez%2C+Ana+P%3BEngle%2C+Ronald+E%3BPurcell%2C+Robert+H%3BLai%2C+Ching-Juh&rft.aulast=Goncalvez&rft.aufirst=Ana&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Amino Acid Substitutions within E and NS5 Proteins Attenuate the Chimeric TBEV/DEN Virus for Neurovirulence in Suckling Mice T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39484472; 4677578 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Engel, Amber R AU - Rumyantsev, Alexander A AU - Pletnev, Alexander G Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Amino acids KW - Mice KW - Suckling behavior KW - NS5 protein KW - Amino acid substitution KW - Neurovirulence KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39484472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Amino+Acid+Substitutions+within+E+and+NS5+Proteins+Attenuate+the+Chimeric+TBEV%2FDEN+Virus+for+Neurovirulence+in+Suckling+Mice&rft.au=Engel%2C+Amber+R%3BRumyantsev%2C+Alexander+A%3BPletnev%2C+Alexander+G&rft.aulast=Engel&rft.aufirst=Amber&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunotoxins to Selectively Deplete Reservoirs of HIV-Infected Cells T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39483837; 4677415 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Kennedy, Paul E AU - Bera, Tapan K AU - Pastan, Ira AU - Berger, Edward A Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Immunotoxins KW - Reservoirs KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39483837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Immunotoxins+to+Selectively+Deplete+Reservoirs+of+HIV-Infected+Cells&rft.au=Kennedy%2C+Paul+E%3BBera%2C+Tapan+K%3BPastan%2C+Ira%3BBerger%2C+Edward+A&rft.aulast=Kennedy&rft.aufirst=Paul&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Live Attenuated Influenza a H7N3 Vaccine Provides Protection Against H7 Viruses from Both Eurasian and North American Lineages T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39483747; 4677599 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - McAuliffe, Josephine M AU - Joseph, Tomy AU - Lu, Bin AU - Jin, Hong AU - Subbarao, Kanta Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - North America KW - Vaccines KW - Influenza KW - Viruses KW - Influenza A KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39483747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=A+Live+Attenuated+Influenza+a+H7N3+Vaccine+Provides+Protection+Against+H7+Viruses+from+Both+Eurasian+and+North+American+Lineages&rft.au=McAuliffe%2C+Josephine+M%3BJoseph%2C+Tomy%3BLu%2C+Bin%3BJin%2C+Hong%3BSubbarao%2C+Kanta&rft.aulast=McAuliffe&rft.aufirst=Josephine&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genotypic Changes in a Tick-Borne Flavivirus Associated with Replication in Tick and Mammalian Systems T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39483706; 4677585 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Mitzel, Dana AU - Wolfinbarger, James AU - Masnick, Max AU - Best, Sonja AU - Bloom, Marshall Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Replication KW - Flavivirus KW - Ixodidae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39483706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Genotypic+Changes+in+a+Tick-Borne+Flavivirus+Associated+with+Replication+in+Tick+and+Mammalian+Systems&rft.au=Mitzel%2C+Dana%3BWolfinbarger%2C+James%3BMasnick%2C+Max%3BBest%2C+Sonja%3BBloom%2C+Marshall&rft.aulast=Mitzel&rft.aufirst=Dana&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Seroepizootiology of Rotavirus Infections in Calves Observed from Birth to One-Year of Age T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39482288; 4678084 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Cao, Dianjun AU - Igboeli, Blessing AU - Yuan, Lijuan AU - Honma, Shinjiro AU - Tatsumi, Masatosh AU - Kapikian, Albert Z AU - Hoshino, Yasutaka Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Infection KW - Birth KW - Age KW - Parturition KW - Rotavirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39482288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Seroepizootiology+of+Rotavirus+Infections+in+Calves+Observed+from+Birth+to+One-Year+of+Age&rft.au=Cao%2C+Dianjun%3BIgboeli%2C+Blessing%3BYuan%2C+Lijuan%3BHonma%2C+Shinjiro%3BTatsumi%2C+Masatosh%3BKapikian%2C+Albert+Z%3BHoshino%2C+Yasutaka&rft.aulast=Cao&rft.aufirst=Dianjun&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - La Crosse Virus Pathogenesis in Mice and Monkeys T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39473071; 4677972 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Bennett, Richard S AU - Cress, Christina M AU - Ward, Jerrold M AU - Firestone, Cai-Yen C AU - Hanson, Christopher T AU - Murphy, Brian R AU - Whitehead, Stephen S Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Mice KW - La Crosse virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39473071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=La+Crosse+Virus+Pathogenesis+in+Mice+and+Monkeys&rft.au=Bennett%2C+Richard+S%3BCress%2C+Christina+M%3BWard%2C+Jerrold+M%3BFirestone%2C+Cai-Yen+C%3BHanson%2C+Christopher+T%3BMurphy%2C+Brian+R%3BWhitehead%2C+Stephen+S&rft.aulast=Bennett&rft.aufirst=Richard&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prophylactic and Therapeutic Efficacy of Human Monoclonal Antibodies Against H5N1 Influenza T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39472390; 4677814 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Suguitan, A L AU - Simmons, C P AU - Bernasconi, N L AU - Ward, J M AU - Van Vin Chau, N AU - Ha, D Quang AU - Farrar, J AU - De Jong, M AU - Lanzavecchia, A AU - Subbarao, K Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Influenza KW - Monoclonal antibodies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39472390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Prophylactic+and+Therapeutic+Efficacy+of+Human+Monoclonal+Antibodies+Against+H5N1+Influenza&rft.au=Suguitan%2C+A+L%3BSimmons%2C+C+P%3BBernasconi%2C+N+L%3BWard%2C+J+M%3BVan+Vin+Chau%2C+N%3BHa%2C+D+Quang%3BFarrar%2C+J%3BDe+Jong%2C+M%3BLanzavecchia%2C+A%3BSubbarao%2C+K&rft.aulast=Suguitan&rft.aufirst=A&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Localization of Murine Norovirus Nonstructural Proteins in Infected Cells T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39471839; 4677262 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Prikhodko, Victor G AU - Kabat, Juraj AU - Green, Kim Y AU - Sosnovtsev, Stanislav V Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Nonstructural proteins KW - Norovirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39471839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Localization+of+Murine+Norovirus+Nonstructural+Proteins+in+Infected+Cells&rft.au=Prikhodko%2C+Victor+G%3BKabat%2C+Juraj%3BGreen%2C+Kim+Y%3BSosnovtsev%2C+Stanislav+V&rft.aulast=Prikhodko&rft.aufirst=Victor&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Poxvirus Primary Membrane Proteins Follow a Default Pathway from Endoplasmic Reticulum to Nascent Viral Membrane T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39464655; 4677346 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Husain, Matloob AU - Moss, Bernard Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Membrane proteins KW - Endoplasmic reticulum KW - Poxvirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39464655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Poxvirus+Primary+Membrane+Proteins+Follow+a+Default+Pathway+from+Endoplasmic+Reticulum+to+Nascent+Viral+Membrane&rft.au=Husain%2C+Matloob%3BMoss%2C+Bernard&rft.aulast=Husain&rft.aufirst=Matloob&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enhancing Expression and Stability of Foreign Genes in Attenuated Poxvirus Recombinant Vaccines T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39461144; 4677737 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Wyatt, Linda AU - Earl, Patricia AU - Americo, Jeffrey AU - Cotter, Catherine AU - Vogt, Jennifer AU - Xiao, Wei AU - Moss, Bernard Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Vaccines KW - Disease control KW - Recombinants KW - Poxvirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39461144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Enhancing+Expression+and+Stability+of+Foreign+Genes+in+Attenuated+Poxvirus+Recombinant+Vaccines&rft.au=Wyatt%2C+Linda%3BEarl%2C+Patricia%3BAmerico%2C+Jeffrey%3BCotter%2C+Catherine%3BVogt%2C+Jennifer%3BXiao%2C+Wei%3BMoss%2C+Bernard&rft.aulast=Wyatt&rft.aufirst=Linda&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mapping Structural Determinants Necessary for DC-SIGN-mediated HIV Transmission T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39459906; 4677658 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Chung, Nancy P AU - Breun, Sabine K AU - Bashirova, Arman A AU - Baumann, Joerg G AU - Martin, Thomas D AU - Wu, Li AU - Carrington, Mary AU - KewalRamani, Vineet N Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Human immunodeficiency virus KW - Mapping KW - Disease transmission KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39459906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Mapping+Structural+Determinants+Necessary+for+DC-SIGN-mediated+HIV+Transmission&rft.au=Chung%2C+Nancy+P%3BBreun%2C+Sabine+K%3BBashirova%2C+Arman+A%3BBaumann%2C+Joerg+G%3BMartin%2C+Thomas+D%3BWu%2C+Li%3BCarrington%2C+Mary%3BKewalRamani%2C+Vineet+N&rft.aulast=Chung&rft.aufirst=Nancy&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association of Vaccinia Virus Fusion Regulatory Proteins with the Multicomponent Entry/ Fusion Complex T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39459282; 4677930 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Wagenaar, Timothy R AU - Moss, Bernard Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Regulatory proteins KW - Vaccinia virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39459282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Association+of+Vaccinia+Virus+Fusion+Regulatory+Proteins+with+the+Multicomponent+Entry%2F+Fusion+Complex&rft.au=Wagenaar%2C+Timothy+R%3BMoss%2C+Bernard&rft.aulast=Wagenaar&rft.aufirst=Timothy&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intranasal Immunization with Parainfluenza Virus-Vectored Vaccines Against Ebola Virus T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39452903; 4677699 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Bukreyev, Alexander AU - Rollin, Pierre AU - DiNapoli, Joshua AU - Tate, Mallory K AU - Yang, Lijuan AU - Zaki, Sherif R AU - Shieh, Wun-Ju AU - Murphy, Brian R AU - Collins, Peter L AU - Sanchez, Anthony Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Vaccines KW - Immunization KW - Parainfluenza KW - Disease control KW - Ebola virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39452903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Intranasal+Immunization+with+Parainfluenza+Virus-Vectored+Vaccines+Against+Ebola+Virus&rft.au=Bukreyev%2C+Alexander%3BRollin%2C+Pierre%3BDiNapoli%2C+Joshua%3BTate%2C+Mallory+K%3BYang%2C+Lijuan%3BZaki%2C+Sherif+R%3BShieh%2C+Wun-Ju%3BMurphy%2C+Brian+R%3BCollins%2C+Peter+L%3BSanchez%2C+Anthony&rft.aulast=Bukreyev&rft.aufirst=Alexander&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Elucidating the Role of the Influenza a Virus Protein PB1-F2 T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39452033; 4677444 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Embry, Alan C AU - Hornung, Felicita AU - Grebe, Kristie M AU - Takeda, Kazuyo AU - Miller, Heather D AU - Russ, Gustav AU - Bennink, Jack R AU - Yewdell, Jonathan W Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Influenza KW - Influenza A virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39452033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Elucidating+the+Role+of+the+Influenza+a+Virus+Protein+PB1-F2&rft.au=Embry%2C+Alan+C%3BHornung%2C+Felicita%3BGrebe%2C+Kristie+M%3BTakeda%2C+Kazuyo%3BMiller%2C+Heather+D%3BRuss%2C+Gustav%3BBennink%2C+Jack+R%3BYewdell%2C+Jonathan+W&rft.aulast=Embry&rft.aufirst=Alan&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Search for Poliovirus Regions that Tolerate Insertions T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39451126; 4677944 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Teterina, Natalya L AU - Levenson, Eric A AU - Ehrenfeld, Ellie Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Poliovirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39451126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=A+Search+for+Poliovirus+Regions+that+Tolerate+Insertions&rft.au=Teterina%2C+Natalya+L%3BLevenson%2C+Eric+A%3BEhrenfeld%2C+Ellie&rft.aulast=Teterina&rft.aufirst=Natalya&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of CTL-Epitopes for Vaccine Development Against Dengue-2 Virus and Parvovirus B19 T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39407686; 4677577 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Amexis, Georgios AU - Keyvanfar, Keyvan AU - Young, Neal S Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Vaccines KW - Disease control KW - Parvovirus B19 KW - Dengue virus type 2 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39407686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Identification+of+CTL-Epitopes+for+Vaccine+Development+Against+Dengue-2+Virus+and+Parvovirus+B19&rft.au=Amexis%2C+Georgios%3BKeyvanfar%2C+Keyvan%3BYoung%2C+Neal+S&rft.aulast=Amexis&rft.aufirst=Georgios&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MEK1/2 Inhibitors Block Basal and TGF-beta Stimulated JC Virus Activity T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39407593; 4677551 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Ravichandran, Veerasamy AU - Jensen, Peter N AU - Major, Eugene O Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Transforming growth factor-b KW - Inhibitors KW - JC virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39407593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=MEK1%2F2+Inhibitors+Block+Basal+and+TGF-beta+Stimulated+JC+Virus+Activity&rft.au=Ravichandran%2C+Veerasamy%3BJensen%2C+Peter+N%3BMajor%2C+Eugene+O&rft.aulast=Ravichandran&rft.aufirst=Veerasamy&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - BIG1/2 and GBF1 as Potentially Critical Cellular Partners of Poliovirus T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39407313; 4677426 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Feng, Qian AU - Belov, George AU - Ehrenfeld, Ellie Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Poliovirus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39407313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=BIG1%2F2+and+GBF1+as+Potentially+Critical+Cellular+Partners+of+Poliovirus&rft.au=Feng%2C+Qian%3BBelov%2C+George%3BEhrenfeld%2C+Ellie&rft.aulast=Feng&rft.aufirst=Qian&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vaccinia Virus Protein G6 is Conserved in All Sequenced Poxviruses but is not Required for Virus Reproduction in Several Cell Lines T2 - 26th Annual Meeting of the American Society for Virology (ASV 2007) AN - 39405988; 4677852 JF - 26th Annual Meeting of the American Society for Virology (ASV 2007) AU - Senkevich, Tatiana G AU - Wyatt, Linda S AU - Moss, Bernard Y1 - 2007/07/14/ PY - 2007 DA - 2007 Jul 14 KW - Reproduction KW - Vaccinia virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39405988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.atitle=Vaccinia+Virus+Protein+G6+is+Conserved+in+All+Sequenced+Poxviruses+but+is+not+Required+for+Virus+Reproduction+in+Several+Cell+Lines&rft.au=Senkevich%2C+Tatiana+G%3BWyatt%2C+Linda+S%3BMoss%2C+Bernard&rft.aulast=Senkevich&rft.aufirst=Tatiana&rft.date=2007-07-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=26th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.miracd.com/asv2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exploring the Cholinergic Control of Somatodendritic Dopamine Release in the VTA of the Mouse Brain T2 - 2007 IBRO International Congress of Neuroscience AN - 39527344; 4639798 JF - 2007 IBRO International Congress of Neuroscience AU - Jones, E L AU - Cragg, S J Y1 - 2007/07/12/ PY - 2007 DA - 2007 Jul 12 KW - Brain KW - Dopamine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39527344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+IBRO+International+Congress+of+Neuroscience&rft.atitle=Exploring+the+Cholinergic+Control+of+Somatodendritic+Dopamine+Release+in+the+VTA+of+the+Mouse+Brain&rft.au=Jones%2C+E+L%3BCragg%2C+S+J&rft.aulast=Jones&rft.aufirst=E&rft.date=2007-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+IBRO+International+Congress+of+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.ibro2007.org/abstracts.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Carboxypeptidase E is Required for Hippocampal Formation, Memory and Learning T2 - 2007 IBRO International Congress of Neuroscience AN - 39523919; 4639979 JF - 2007 IBRO International Congress of Neuroscience AU - Woronowicz, A AU - Chang, S.-Y. AU - Cawley, N AU - Hill, J AU - Abebe, D AU - Dorfman, C AU - Xiong, Z AU - Loh, Y P Y1 - 2007/07/12/ PY - 2007 DA - 2007 Jul 12 KW - Learning KW - Carboxypeptidase E KW - Hippocampus KW - Memory KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39523919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+IBRO+International+Congress+of+Neuroscience&rft.atitle=Carboxypeptidase+E+is+Required+for+Hippocampal+Formation%2C+Memory+and+Learning&rft.au=Woronowicz%2C+A%3BChang%2C+S.-Y.%3BCawley%2C+N%3BHill%2C+J%3BAbebe%2C+D%3BDorfman%2C+C%3BXiong%2C+Z%3BLoh%2C+Y+P&rft.aulast=Woronowicz&rft.aufirst=A&rft.date=2007-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+IBRO+International+Congress+of+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.ibro2007.org/abstracts.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Two Proteins Involve in Mediating the Cellular Actions of the Corticotropin Releasing Factor (CRF), CRF-Receptor 1 and CRF-Binding Protein, are Present in Dopaminergic Neurons in the Ventral Tegmental Area (VTA) T2 - 2007 IBRO International Congress of Neuroscience AN - 39438184; 4640551 JF - 2007 IBRO International Congress of Neuroscience AU - Tagliaferro, P AU - Wang, H L AU - Morales, M Y1 - 2007/07/12/ PY - 2007 DA - 2007 Jul 12 KW - Corticotropin-releasing hormone KW - Ventral tegmentum KW - Neurons KW - Dopamine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39438184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+IBRO+International+Congress+of+Neuroscience&rft.atitle=Two+Proteins+Involve+in+Mediating+the+Cellular+Actions+of+the+Corticotropin+Releasing+Factor+%28CRF%29%2C+CRF-Receptor+1+and+CRF-Binding+Protein%2C+are+Present+in+Dopaminergic+Neurons+in+the+Ventral+Tegmental+Area+%28VTA%29&rft.au=Tagliaferro%2C+P%3BWang%2C+H+L%3BMorales%2C+M&rft.aulast=Tagliaferro&rft.aufirst=P&rft.date=2007-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+IBRO+International+Congress+of+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.ibro2007.org/abstracts.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of BDNF Trafficking and Secretion: Implications in Neuronal Plasticity and Cognitive Functions T2 - 2007 IBRO International Congress of Neuroscience AN - 39435866; 4639986 JF - 2007 IBRO International Congress of Neuroscience AU - Lu, B. Y1 - 2007/07/12/ PY - 2007 DA - 2007 Jul 12 KW - Cognitive ability KW - Secretion KW - Brain-derived neurotrophic factor KW - Plasticity (neural) KW - Plasticity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39435866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+IBRO+International+Congress+of+Neuroscience&rft.atitle=Regulation+of+BDNF+Trafficking+and+Secretion%3A+Implications+in+Neuronal+Plasticity+and+Cognitive+Functions&rft.au=Lu%2C+B.&rft.aulast=Lu&rft.aufirst=B.&rft.date=2007-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+IBRO+International+Congress+of+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.ibro2007.org/abstracts.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Estrogen Receptor a Localization in the Prefrontal Cortex of Three Mammalian Species T2 - 2007 IBRO International Congress of Neuroscience AN - 39434480; 4640376 JF - 2007 IBRO International Congress of Neuroscience AU - Montague-Couch, D AU - Rothmond, D A AU - Tomaskovic-Crook, E AU - Kleinman, J E AU - Rubinow, D R AU - Weickert, C S Y1 - 2007/07/12/ PY - 2007 DA - 2007 Jul 12 KW - Estrogen receptors KW - Cortex (prefrontal) KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39434480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+IBRO+International+Congress+of+Neuroscience&rft.atitle=Estrogen+Receptor+a+Localization+in+the+Prefrontal+Cortex+of+Three+Mammalian+Species&rft.au=Montague-Couch%2C+D%3BRothmond%2C+D+A%3BTomaskovic-Crook%2C+E%3BKleinman%2C+J+E%3BRubinow%2C+D+R%3BWeickert%2C+C+S&rft.aulast=Montague-Couch&rft.aufirst=D&rft.date=2007-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+IBRO+International+Congress+of+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.ibro2007.org/abstracts.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activity-Dependent Communication between AXONS and GLIA T2 - 2007 IBRO International Congress of Neuroscience AN - 39413633; 4639525 JF - 2007 IBRO International Congress of Neuroscience AU - Fields, R D Y1 - 2007/07/12/ PY - 2007 DA - 2007 Jul 12 KW - Communication KW - Glia KW - Axons KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39413633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+IBRO+International+Congress+of+Neuroscience&rft.atitle=Activity-Dependent+Communication+between+AXONS+and+GLIA&rft.au=Fields%2C+R+D&rft.aulast=Fields&rft.aufirst=R&rft.date=2007-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+IBRO+International+Congress+of+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.ibro2007.org/abstracts.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Normal Indian Human Brains do not Show Age-Related Loss or Morphological Changes in Melanized Neurons in Substantia Nigra Pars Compacta: A Stereological Study T2 - 2007 IBRO International Congress of Neuroscience AN - 39413495; 4639149 JF - 2007 IBRO International Congress of Neuroscience AU - Alladi, P A AU - Mahadevan, A AU - Yasha, T C AU - Raju, T R AU - Shankar, S K AU - Muthane, U Y1 - 2007/07/12/ PY - 2007 DA - 2007 Jul 12 KW - Brain KW - Substantia nigra KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39413495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+IBRO+International+Congress+of+Neuroscience&rft.atitle=Normal+Indian+Human+Brains+do+not+Show+Age-Related+Loss+or+Morphological+Changes+in+Melanized+Neurons+in+Substantia+Nigra+Pars+Compacta%3A+A+Stereological+Study&rft.au=Alladi%2C+P+A%3BMahadevan%2C+A%3BYasha%2C+T+C%3BRaju%2C+T+R%3BShankar%2C+S+K%3BMuthane%2C+U&rft.aulast=Alladi&rft.aufirst=P&rft.date=2007-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+IBRO+International+Congress+of+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.ibro2007.org/abstracts.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neural Mechanisms Underlying Probabilistic Category Learning in Patients with Schizophrenia T2 - 2007 IBRO International Congress of Neuroscience AN - 39410559; 4640701 JF - 2007 IBRO International Congress of Neuroscience AU - Weickert, T W AU - Goldberg, T E AU - Chen, Q AU - Callicott, J H AU - Apud, J A AU - Das, S AU - Weinberger, D R AU - Mattay, V S Y1 - 2007/07/12/ PY - 2007 DA - 2007 Jul 12 KW - Schizophrenia KW - Learning KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39410559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+IBRO+International+Congress+of+Neuroscience&rft.atitle=Neural+Mechanisms+Underlying+Probabilistic+Category+Learning+in+Patients+with+Schizophrenia&rft.au=Weickert%2C+T+W%3BGoldberg%2C+T+E%3BChen%2C+Q%3BCallicott%2C+J+H%3BApud%2C+J+A%3BDas%2C+S%3BWeinberger%2C+D+R%3BMattay%2C+V+S&rft.aulast=Weickert&rft.aufirst=T&rft.date=2007-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+IBRO+International+Congress+of+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.ibro2007.org/abstracts.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of Pin1 Reduces Perikaryal Accumulation of Phosphorylated NF-H and Neuronal Death T2 - 2007 IBRO International Congress of Neuroscience AN - 39373248; 4639838 JF - 2007 IBRO International Congress of Neuroscience AU - Kesavapany, S AU - Patel, V AU - Pareek, T K AU - Bjelogrlic, M AU - Albers, W AU - Strong, M AU - Gutkind, J S AU - Pant, H C Y1 - 2007/07/12/ PY - 2007 DA - 2007 Jul 12 KW - Mortality KW - Pin1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39373248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+IBRO+International+Congress+of+Neuroscience&rft.atitle=Inhibition+of+Pin1+Reduces+Perikaryal+Accumulation+of+Phosphorylated+NF-H+and+Neuronal+Death&rft.au=Kesavapany%2C+S%3BPatel%2C+V%3BPareek%2C+T+K%3BBjelogrlic%2C+M%3BAlbers%2C+W%3BStrong%2C+M%3BGutkind%2C+J+S%3BPant%2C+H+C&rft.aulast=Kesavapany&rft.aufirst=S&rft.date=2007-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+IBRO+International+Congress+of+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.ibro2007.org/abstracts.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oxidant-Mediated Aggregation of Mouse Brain CA2+/Calmodulin-Dependent Protein Kinase II T2 - 2007 IBRO International Congress of Neuroscience AN - 39373187; 4639728 JF - 2007 IBRO International Congress of Neuroscience AU - Shetty, P AU - Huang, F AU - Huang, K Y1 - 2007/07/12/ PY - 2007 DA - 2007 Jul 12 KW - Brain KW - Ca super(2+)/calmodulin-dependent protein kinase KW - Calcium KW - Ca super(2+)/calmodulin-dependent protein kinase II KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39373187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+IBRO+International+Congress+of+Neuroscience&rft.atitle=Oxidant-Mediated+Aggregation+of+Mouse+Brain+CA2%2B%2FCalmodulin-Dependent+Protein+Kinase+II&rft.au=Shetty%2C+P%3BHuang%2C+F%3BHuang%2C+K&rft.aulast=Shetty&rft.aufirst=P&rft.date=2007-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+IBRO+International+Congress+of+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.ibro2007.org/abstracts.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Valproic Acid and Other HDAC Inhibitors Induce Microglial Apoptosis and Attenuate Lipopolysaccharide-Induced Dopaminergic Neurotoxicity T2 - 2007 IBRO International Congress of Neuroscience AN - 39370701; 4639350 JF - 2007 IBRO International Congress of Neuroscience AU - Chen, P S AU - Wang, C C AU - Wu, X. AU - Pang, H AU - Lu, R B AU - Gean, P W AU - Chuang, D M AU - Hong, J S Y1 - 2007/07/12/ PY - 2007 DA - 2007 Jul 12 KW - Neurotoxicity KW - Valproic acid KW - Apoptosis KW - Histone deacetylase KW - Dopamine KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39370701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+IBRO+International+Congress+of+Neuroscience&rft.atitle=Valproic+Acid+and+Other+HDAC+Inhibitors+Induce+Microglial+Apoptosis+and+Attenuate+Lipopolysaccharide-Induced+Dopaminergic+Neurotoxicity&rft.au=Chen%2C+P+S%3BWang%2C+C+C%3BWu%2C+X.%3BPang%2C+H%3BLu%2C+R+B%3BGean%2C+P+W%3BChuang%2C+D+M%3BHong%2C+J+S&rft.aulast=Chen&rft.aufirst=P&rft.date=2007-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+IBRO+International+Congress+of+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.ibro2007.org/abstracts.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transgenic Mice Expressing Fluorescent CA Indicator in Astrocytes and Schwann Cells Allow for Recording Stimulus Dependent Glial Cell CA Signals in Situ T2 - 2007 IBRO International Congress of Neuroscience AN - 39368553; 4640385 JF - 2007 IBRO International Congress of Neuroscience AU - Atkin, S D AU - Holtzclaw, L A AU - Weerth, S AU - Pickel, J AU - Russell, J T Y1 - 2007/07/12/ PY - 2007 DA - 2007 Jul 12 KW - Mice KW - Schwann cells KW - Glial cells KW - Astrocytes KW - Transgenic mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39368553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+IBRO+International+Congress+of+Neuroscience&rft.atitle=Transgenic+Mice+Expressing+Fluorescent+CA+Indicator+in+Astrocytes+and+Schwann+Cells+Allow+for+Recording+Stimulus+Dependent+Glial+Cell+CA+Signals+in+Situ&rft.au=Atkin%2C+S+D%3BHoltzclaw%2C+L+A%3BWeerth%2C+S%3BPickel%2C+J%3BRussell%2C+J+T&rft.aulast=Atkin&rft.aufirst=S&rft.date=2007-07-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+IBRO+International+Congress+of+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.ibro2007.org/abstracts.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Toward Improved Syntheses of Dendrimer-Based Magnetic Resonance Imaging Contrast Agents: New Bifunctional Diethylenetriaminepentaacetic Acid Ligands and Nonaqueous Conjugation Chemistry AN - 20265965; 7568387 AB - Two different fourth-generation (G4) polyaminonamido dendrimer-based magnetic resonsance (MR) agents were prepared by a new synthetic approach wherein tert-butyl-protected forms of 2-(4-isothiocyanatobenzyl)-6-methyldiethylenetriamine pentaacetic acid (1B4M-DTPA), bearing either an isothiocyanate or a succinimidyl ester moiety, respectively, were conjugated to the primary amines of the dendrimer. Purification was facilitated using a solid phase, N-(2-aminoethyl)aminomethyl polystyrene. After Gd(III) incorporation, molar relaxivity measurements of both new dendrimer-based agents as compared to a G4 agent prepared by an aqueous chemistry route indicated no significant changes in relaxivity. Comparative MR imaging revealed equivalent enhancement of the vessels and organs such as the kidney and liver, although slightly different vascular clearance rates were observed. This general synthesis provides a procedure for preparation of dendrimer-based MR agents for clinical applications with higher yields and efficiency while enhancing versatility. The latter aspect is further demonstrated by preparation of a novel maleimide analog of 1B4M-DTPA from a key synthetic intermediate aniline derivative. JF - Journal of Medicinal Chemistry AU - Xu, H AU - Regino, CAS AU - Bernardo, M AU - Koyama, Y AU - Kobayashi, H AU - Choyke, P L AU - Brechbiel, M W AD - Radiation Oncology Branch and Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892-1088, USA Y1 - 2007/07/12/ PY - 2007 DA - 2007 Jul 12 SP - 3185 EP - 3193 VL - 50 IS - 14 SN - 0022-2623, 0022-2623 KW - Biotechnology and Bioengineering Abstracts KW - amines KW - Magnetic resonance imaging KW - Liver KW - Contrast media KW - Kidney KW - polystyrene KW - Esters KW - isothiocyanate KW - Aniline KW - Vascular system KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20265965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medicinal+Chemistry&rft.atitle=Toward+Improved+Syntheses+of+Dendrimer-Based+Magnetic+Resonance+Imaging+Contrast+Agents%3A+New+Bifunctional+Diethylenetriaminepentaacetic+Acid+Ligands+and+Nonaqueous+Conjugation+Chemistry&rft.au=Xu%2C+H%3BRegino%2C+CAS%3BBernardo%2C+M%3BKoyama%2C+Y%3BKobayashi%2C+H%3BChoyke%2C+P+L%3BBrechbiel%2C+M+W&rft.aulast=Xu&rft.aufirst=H&rft.date=2007-07-12&rft.volume=50&rft.issue=14&rft.spage=3185&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medicinal+Chemistry&rft.issn=00222623&rft_id=info:doi/10.1021%2Fjm061324m LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; Esters; polystyrene; Kidney; Contrast media; Liver; isothiocyanate; amines; Vascular system; Aniline DO - http://dx.doi.org/10.1021/jm061324m ER - TY - JOUR T1 - Synthesis and Simple super(18)F-Labeling of 3-Fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a High Affinity Radioligand for Imaging Monkey Brain Metabotropic Glutamate Subtype-5 Receptors with Positron Emission Tomography AN - 19756162; 7568390 AB - 2-Fluoromethyl analogs of (3-[(2-methyl-1,3-thiazol-4yl)ethynyl]pyridine) were synthesized as potential ligands for metabotropic glutamate subtype-5 receptors (mGluR5s). One of these, namely, 3-fiuoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile (3), was found to have exceptionally high affinity (IC sub(50) = 36 pM) and potency in a phosphoinositol hydrolysis assay (IC sub(50) = 0.714 pM) for mGluR5. Compound 3 was labeled with fluorine-18 (t sub( one half ) = 109.7 min) in high radiochemical yield (87%) by treatment of its synthesized bromomethyl analog (17) with [ super(18)F]fluoride ion and its radioligand behavior was assessed with positron emission tomography (PET). Following intravenous injection of [ super(18)F]3 into rhesus monkey, radioactivity was avidly taken up into brain with high uptake in mGluR5 receptor-rich regions such as striata. [ super(18)F]3 was stable in monkey plasma and human whole blood in vitro and in monkey and human brain homogenates. In monkey in vivo, a single polar radiometabolite of [ super(18)F]3 appeared rapidly in plasma. [ super(18)F]3 merits further evaluation as a PET radioligand for mGluR5 in human subjects. JF - Journal of Medicinal Chemistry AU - Simeon, F G AU - Brown, A K AU - Zoghbi, S S AU - Patterson, V M AU - Innis, R B AU - Pike, V W AD - Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3 C346A, 10 Center Drive, Bethesda, Maryland 20892-1003, USA Y1 - 2007/07/12/ PY - 2007 DA - 2007 Jul 12 SP - 3256 EP - 3266 VL - 50 IS - 14 SN - 0022-2623, 0022-2623 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Intravenous administration KW - Neuroimaging KW - Glutamic acid receptors (metabotropic) KW - Brain KW - Hydrolysis KW - Blood KW - Positron emission tomography KW - Macaca mulatta KW - Radioactivity KW - Glutamic acid KW - N3 11008:Neurochemistry KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19756162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medicinal+Chemistry&rft.atitle=Synthesis+and+Simple+super%2818%29F-Labeling+of+3-Fluoro-5-%282-%282-%28fluoromethyl%29thiazol-4-yl%29ethynyl%29benzonitrile+as+a+High+Affinity+Radioligand+for+Imaging+Monkey+Brain+Metabotropic+Glutamate+Subtype-5+Receptors+with+Positron+Emission+Tomography&rft.au=Simeon%2C+F+G%3BBrown%2C+A+K%3BZoghbi%2C+S+S%3BPatterson%2C+V+M%3BInnis%2C+R+B%3BPike%2C+V+W&rft.aulast=Simeon&rft.aufirst=F&rft.date=2007-07-12&rft.volume=50&rft.issue=14&rft.spage=3256&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medicinal+Chemistry&rft.issn=00222623&rft_id=info:doi/10.1021%2Fjm0701268 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Macaca mulatta; Glutamic acid receptors (metabotropic); Positron emission tomography; Glutamic acid; Neuroimaging; Brain; Intravenous administration; Blood; Hydrolysis; Radioactivity DO - http://dx.doi.org/10.1021/jm0701268 ER - TY - CPAPER T1 - Association between Midlife Physical Activity and Late-Life Infarcts Detected on MRI T2 - 3rd Congress of the International Society for Vascular, Cognitive and Behavioural Disorders (Vas-Cog 2007) AN - 39501840; 4663943 JF - 3rd Congress of the International Society for Vascular, Cognitive and Behavioural Disorders (Vas-Cog 2007) AU - Launer, Lenore AU - Jonsson, Palmi V AU - Harris, Tamara AU - Gudnason, Vilmundur AU - Pajala, Satu AU - Sigurdsson, Gunnar AU - Chang, Miran J Y1 - 2007/07/11/ PY - 2007 DA - 2007 Jul 11 KW - Physical activity KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39501840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+Congress+of+the+International+Society+for+Vascular%2C+Cognitive+and+Behavioural+Disorders+%28Vas-Cog+2007%29&rft.atitle=Association+between+Midlife+Physical+Activity+and+Late-Life+Infarcts+Detected+on+MRI&rft.au=Launer%2C+Lenore%3BJonsson%2C+Palmi+V%3BHarris%2C+Tamara%3BGudnason%2C+Vilmundur%3BPajala%2C+Satu%3BSigurdsson%2C+Gunnar%3BChang%2C+Miran+J&rft.aulast=Launer&rft.aufirst=Lenore&rft.date=2007-07-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+Congress+of+the+International+Society+for+Vascular%2C+Cognitive+and+Behavioural+Disorders+%28Vas-Cog+2007%29&rft.issn=&rft_id=info:doi/ L2 - https://www5.shocklogic.com/scripts/ProgrammeLogic/ProgrammeLogic.asp? Client_Id='CXST'&Project_Id='07070708'&Form_Id=3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Diabetes and Cognitive Performance: The Age Gene/Environment Susceptibility -Reykjavik Study (AGES-Reykjavik) T2 - 3rd Congress of the International Society for Vascular, Cognitive and Behavioural Disorders (Vas-Cog 2007) AN - 39431698; 4663937 JF - 3rd Congress of the International Society for Vascular, Cognitive and Behavioural Disorders (Vas-Cog 2007) AU - Launer, Lenore J AU - Olafsdottir, Elin AU - Harris, Tamara AU - Gundason, Vilmundur AU - Garcia, Melissa E AU - Jonsson, Palmi V AU - Eiriksdottir, Gudny AU - Saczynski, Jane S AU - Peila, Rita AU - Jonsdottir, Maria K Y1 - 2007/07/11/ PY - 2007 DA - 2007 Jul 11 KW - Cognitive ability KW - Diabetes mellitus KW - Age KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39431698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=3rd+Congress+of+the+International+Society+for+Vascular%2C+Cognitive+and+Behavioural+Disorders+%28Vas-Cog+2007%29&rft.atitle=Diabetes+and+Cognitive+Performance%3A+The+Age+Gene%2FEnvironment+Susceptibility+-Reykjavik+Study+%28AGES-Reykjavik%29&rft.au=Launer%2C+Lenore+J%3BOlafsdottir%2C+Elin%3BHarris%2C+Tamara%3BGundason%2C+Vilmundur%3BGarcia%2C+Melissa+E%3BJonsson%2C+Palmi+V%3BEiriksdottir%2C+Gudny%3BSaczynski%2C+Jane+S%3BPeila%2C+Rita%3BJonsdottir%2C+Maria+K&rft.aulast=Launer&rft.aufirst=Lenore&rft.date=2007-07-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=3rd+Congress+of+the+International+Society+for+Vascular%2C+Cognitive+and+Behavioural+Disorders+%28Vas-Cog+2007%29&rft.issn=&rft_id=info:doi/ L2 - https://www5.shocklogic.com/scripts/ProgrammeLogic/ProgrammeLogic.asp? Client_Id='CXST'&Project_Id='07070708'&Form_Id=3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Amino-terminal domain of TIF2 is involved in competing for corepressor binding to glucocorticoid and progesterone receptors. AN - 70663706; 17571860 AB - Both agonist- and antagonist-bound glucocorticoid receptors (GRs) and progesterone receptors (PRs) regulate gene transcription with the assistance of corepressors (NCoR and SMRT) and coactivators (TIF2/GRIP1, SRC1, and AIB1). Receptor binding of these cofactors is competitive and is considered to involve interactions between the C-terminal ligand binding domain of receptors and receptor interaction domains (RIDs) in the middle and C-terminus of coactivators and corepressors, respectively. Therefore, our recent finding that an amino terminal fragment of TIF2 (TIF2.0 = amino acids 1-627) competed for GR and PR interactions with corepressors in mammalian two-hybrid assays was unexpected. Here, we use biochemical approaches (mammalian two-hybrid, pull-down, and coimmunoprecipitation assays) to locate an N-terminal GR region that is sufficient to bind TIF2.0. In contrast, an N-terminal sequence of PR-B that is largely missing in the shorter PR-A is necessary but not sufficient for TIF2.0 binding. Mutagenesis studies of NCoR establish that the more amino-terminal RID#1, but not RID#2, is necessary for binding to both GR and PR agonist and antagonist complexes. ChIP assays indicate that PR and NCoR each selectively localize to the enhancer element (PRE) of a transiently transfected PREtkLUC reporter in the presence of antagonist steroid, whereas exogenous TIF2.0 reduces the amount of PRE-associated NCoR. Importantly, exogenous TIF2.0 also inhibits the biological responses to added NCoR under the same conditions as those used in the ChIP assays. These results suggest that both N-terminal and middle sequences of TIF2 participate in competing with corepressor for regulating the gene transcriptional responses of GRs and PRs. JF - Biochemistry AU - Wang, Dongqing AU - Wang, Qi AU - Awasthi, Smita AU - Simons, S Stoney AD - Steroid Hormones Section, NIDDK/CEB, National Institutes of Health, Bethesda, Maryland 20892-1772, USA. Y1 - 2007/07/10/ PY - 2007 DA - 2007 Jul 10 SP - 8036 EP - 8049 VL - 46 IS - 27 SN - 0006-2960, 0006-2960 KW - DNA Primers KW - 0 KW - NCOA2 protein, human KW - Nuclear Receptor Coactivator 2 KW - Receptors, Glucocorticoid KW - Receptors, Progesterone KW - Index Medicus KW - Base Sequence KW - Two-Hybrid System Techniques KW - Chromatin Immunoprecipitation KW - Reverse Transcriptase Polymerase Chain Reaction KW - Protein Binding KW - Receptors, Progesterone -- metabolism KW - Nuclear Receptor Coactivator 2 -- metabolism KW - Nuclear Receptor Coactivator 2 -- chemistry KW - Receptors, Glucocorticoid -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70663706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Amino-terminal+domain+of+TIF2+is+involved+in+competing+for+corepressor+binding+to+glucocorticoid+and+progesterone+receptors.&rft.au=Wang%2C+Dongqing%3BWang%2C+Qi%3BAwasthi%2C+Smita%3BSimons%2C+S+Stoney&rft.aulast=Wang&rft.aufirst=Dongqing&rft.date=2007-07-10&rft.volume=46&rft.issue=27&rft.spage=8036&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-18 N1 - Date created - 2007-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hazardous alcohol users during pregnancy: Psychiatric health and personality traits AN - 57060866; 200719257 AB - Background: We examined alcohol use disorders, psychiatric symptoms and personality traits in women reporting alcohol use during pregnancy. Methods: In a pilot cohort (n=139), subjects were screened for alcohol use disorders, and assessed for psychopathology, personality traits, and alcohol use during the first trimester. Those reporting consumption exceeding a conservative threshold for harmful use were offered a diagnostic psychiatric interview. The main findings of the pilot study were replicated using a large sample of women in the third trimester (n=715), who were screened for alcohol use disorders, had their consumption during pregnancy assessed, and were assessed for personality traits. Results: In the pilot cohort, only a minority of women who consumed significant amounts of alcohol during pregnancy fulfilled alcohol dependence criteria, or had scores on the Alcohol Use Disorder Identification Test typically associated with such a diagnosis. Psychiatric morbidity was also unremarkable as assessed by self-reported symptom intensity. The distinguishing feature was high novelty seeking. The results were robustly confirmed in the replication study. Conclusions: Most women with significant alcohol consumption during pregnancy do not seem to be alcohol dependent. Instead, use during pregnancy may reflect impulsive personality traits, and be correlated with additional risk behaviors. [Copyright 2007 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Magnusson, Asa AU - Goransson, Mona AU - Heilig, Markus AD - Department of Clinical Neuroscience, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden Y1 - 2007/07/10/ PY - 2007 DA - 2007 Jul 10 SP - 275 EP - 281 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 89 IS - 2-3 SN - 0376-8716, 0376-8716 KW - Pregnancy KW - Alcohol KW - Hazardous use KW - Fetal alcohol spectrum disorders KW - Personality KW - Impulsivity KW - Novelty seeking KW - Fetal development KW - Problem drinking KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57060866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Hazardous+alcohol+users+during+pregnancy%3A+Psychiatric+health+and+personality+traits&rft.au=Magnusson%2C+Asa%3BGoransson%2C+Mona%3BHeilig%2C+Markus&rft.aulast=Magnusson&rft.aufirst=Asa&rft.date=2007-07-10&rft.volume=89&rft.issue=2-3&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2007.01.015 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-11-01 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Pregnancy; Personality; Fetal development; Problem drinking; Novelty seeking; Impulsivity DO - http://dx.doi.org/10.1016/j.drugalcdep.2007.01.015 ER - TY - CPAPER T1 - In Vivo Synergy of TLR Ligands in Inducing Mucosal Immunity Agianst Virus Infection T2 - 13th International Congress of Mucosal Immunology (ICMI 2007) AN - 39453793; 4650588 JF - 13th International Congress of Mucosal Immunology (ICMI 2007) AU - Zhu, Qing AU - Belyakov, Igor M AU - Uematsu, Satoshi AU - Akira, Shizuo AU - Dennis, Klinman M AU - Berzofsky, Jay A Y1 - 2007/07/09/ PY - 2007 DA - 2007 Jul 09 KW - Infection KW - Mucosal immunity KW - Immunity KW - Ligands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39453793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Mucosal+Immunology+%28ICMI+2007%29&rft.atitle=In+Vivo+Synergy+of+TLR+Ligands+in+Inducing+Mucosal+Immunity+Agianst+Virus+Infection&rft.au=Zhu%2C+Qing%3BBelyakov%2C+Igor+M%3BUematsu%2C+Satoshi%3BAkira%2C+Shizuo%3BDennis%2C+Klinman+M%3BBerzofsky%2C+Jay+A&rft.aulast=Zhu&rft.aufirst=Qing&rft.date=2007-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Mucosal+Immunology+%28ICMI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www2.convention.co.jp/icmi2007/sp.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Smad4 is Dispensable for Th17 Differentiation but Negatively Regulates IL-17 Production in CD8+ T Cells T2 - 13th International Congress of Mucosal Immunology (ICMI 2007) AN - 39437661; 4650889 JF - 13th International Congress of Mucosal Immunology (ICMI 2007) AU - Chen, Wanjun AU - Li, Jun AU - Liu, Yongzhong Y1 - 2007/07/09/ PY - 2007 DA - 2007 Jul 09 KW - CD8 antigen KW - Interleukin 17 KW - Differentiation KW - Lymphocytes T KW - Smad4 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39437661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Mucosal+Immunology+%28ICMI+2007%29&rft.atitle=Smad4+is+Dispensable+for+Th17+Differentiation+but+Negatively+Regulates+IL-17+Production+in+CD8%2B+T+Cells&rft.au=Chen%2C+Wanjun%3BLi%2C+Jun%3BLiu%2C+Yongzhong&rft.aulast=Chen&rft.aufirst=Wanjun&rft.date=2007-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Mucosal+Immunology+%28ICMI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www2.convention.co.jp/icmi2007/sp.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NOD2 Transgenic Mice Exhibit Enhanced MDP-mediated Down-Regulation of TLR2 Responses and Resistance to Colitis-Induction T2 - 13th International Congress of Mucosal Immunology (ICMI 2007) AN - 39364299; 4650897 JF - 13th International Congress of Mucosal Immunology (ICMI 2007) AU - Kitani, Atsushi AU - Yang, Zhiqiong AU - Watanabe, Tomohiro AU - Asano, Naoki AU - Fuss, Ivan J AU - Strober, Warren Y1 - 2007/07/09/ PY - 2007 DA - 2007 Jul 09 KW - Mice KW - TLR2 protein KW - Toll-like receptors KW - NOD2 protein KW - Transgenic mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39364299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Mucosal+Immunology+%28ICMI+2007%29&rft.atitle=NOD2+Transgenic+Mice+Exhibit+Enhanced+MDP-mediated+Down-Regulation+of+TLR2+Responses+and+Resistance+to+Colitis-Induction&rft.au=Kitani%2C+Atsushi%3BYang%2C+Zhiqiong%3BWatanabe%2C+Tomohiro%3BAsano%2C+Naoki%3BFuss%2C+Ivan+J%3BStrober%2C+Warren&rft.aulast=Kitani&rft.aufirst=Atsushi&rft.date=2007-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Mucosal+Immunology+%28ICMI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www2.convention.co.jp/icmi2007/sp.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Association of Th1 and Th17 Cells with Colitis in Gi2a super(-/-) Mice and in the Adoptive Transfer C57BL/10 RAG-2 super(-/-) Mice T2 - 13th International Congress of Mucosal Immunology (ICMI 2007) AN - 39363912; 4650811 JF - 13th International Congress of Mucosal Immunology (ICMI 2007) AU - He, Jianping AU - Valatas, Vasileios AU - Leon, Francisco AU - Kelsall, Brian L Y1 - 2007/07/09/ PY - 2007 DA - 2007 Jul 09 KW - Mice KW - Colitis KW - Lymphocytes T KW - Adoptive transfer KW - Helper cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39363912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Mucosal+Immunology+%28ICMI+2007%29&rft.atitle=Differential+Association+of+Th1+and+Th17+Cells+with+Colitis+in+Gi2a+super%28-%2F-%29+Mice+and+in+the+Adoptive+Transfer+C57BL%2F10+RAG-2+super%28-%2F-%29+Mice&rft.au=He%2C+Jianping%3BValatas%2C+Vasileios%3BLeon%2C+Francisco%3BKelsall%2C+Brian+L&rft.aulast=He&rft.aufirst=Jianping&rft.date=2007-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Mucosal+Immunology+%28ICMI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www2.convention.co.jp/icmi2007/sp.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Monocytes are Precursors of CD11b+ Dendritic Cells and Macrophages in the GI Tract T2 - 13th International Congress of Mucosal Immunology (ICMI 2007) AN - 39360011; 4650612 JF - 13th International Congress of Mucosal Immunology (ICMI 2007) AU - Rivollier, Aymeric AU - Kelsall, Brian L Y1 - 2007/07/09/ PY - 2007 DA - 2007 Jul 09 KW - CD11b antigen KW - Dendritic cells KW - Monocytes KW - Macrophages KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39360011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Mucosal+Immunology+%28ICMI+2007%29&rft.atitle=Monocytes+are+Precursors+of+CD11b%2B+Dendritic+Cells+and+Macrophages+in+the+GI+Tract&rft.au=Rivollier%2C+Aymeric%3BKelsall%2C+Brian+L&rft.aulast=Rivollier&rft.aufirst=Aymeric&rft.date=2007-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Mucosal+Immunology+%28ICMI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www2.convention.co.jp/icmi2007/sp.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cancer Incidence in the Atomic Bomb Surivors: The New Incidence Report. T2 - 13th International Congress of Radiation Research (ICRR 2007) AN - 39568504; 4659299 JF - 13th International Congress of Radiation Research (ICRR 2007) AU - Mabuchi, Kiyohiko AU - Preston, Dale L AU - Ron, Elaine AU - Tokuoka, Shoji AU - Funamoto, Sachiyo AU - Nishi, Nobuo AU - Soda, Midori AU - Kodama, Kazunori Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Cancer KW - Atomic bombs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39568504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.atitle=Cancer+Incidence+in+the+Atomic+Bomb+Surivors%3A+The+New+Incidence+Report.&rft.au=Mabuchi%2C+Kiyohiko%3BPreston%2C+Dale+L%3BRon%2C+Elaine%3BTokuoka%2C+Shoji%3BFunamoto%2C+Sachiyo%3BNishi%2C+Nobuo%3BSoda%2C+Midori%3BKodama%2C+Kazunori&rft.aulast=Mabuchi&rft.aufirst=Kiyohiko&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://171.65.6.67/icrr2007/pages_newbrwsrs/program_scientific_nb.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Loratadine-Mediated Enhancement of Radiation Response. T2 - 13th International Congress of Radiation Research (ICRR 2007) AN - 39525756; 4659622 JF - 13th International Congress of Radiation Research (ICRR 2007) AU - Soule, Benjamin P AU - Simone, Nicole L AU - DeGraff, William AU - Cook, John A AU - Mitchell, James B Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Radiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39525756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.atitle=Loratadine-Mediated+Enhancement+of+Radiation+Response.&rft.au=Soule%2C+Benjamin+P%3BSimone%2C+Nicole+L%3BDeGraff%2C+William%3BCook%2C+John+A%3BMitchell%2C+James+B&rft.aulast=Soule&rft.aufirst=Benjamin&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://171.65.6.67/icrr2007/pages_newbrwsrs/program_scientific_nb.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - g-H2AX in Blood as a Biomarker for Low Dose Irradiation Exposure. T2 - 13th International Congress of Radiation Research (ICRR 2007) AN - 39503749; 4659632 JF - 13th International Congress of Radiation Research (ICRR 2007) AU - Redon, Christophe E AU - Sedelnikova, Olga A AU - Bonner, William M Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Bioindicators KW - Irradiation KW - Radiation KW - Blood KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39503749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.atitle=g-H2AX+in+Blood+as+a+Biomarker+for+Low+Dose+Irradiation+Exposure.&rft.au=Redon%2C+Christophe+E%3BSedelnikova%2C+Olga+A%3BBonner%2C+William+M&rft.aulast=Redon&rft.aufirst=Christophe&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://171.65.6.67/icrr2007/pages_newbrwsrs/program_scientific_nb.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The NCIs Clinical Proteomic Technology Initiative for Cancer - The Reagent Resource Core T2 - Seventeenth Biennial Meeting of the International Society for Molecular Recognition (AFFINITY 2007) AN - 39498933; 4681793 JF - Seventeenth Biennial Meeting of the International Society for Molecular Recognition (AFFINITY 2007) AU - Clark, Adam Michael Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Cancer KW - Technology KW - Proteomics KW - Cores KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39498933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Seventeenth+Biennial+Meeting+of+the+International+Society+for+Molecular+Recognition+%28AFFINITY+2007%29&rft.atitle=The+NCIs+Clinical+Proteomic+Technology+Initiative+for+Cancer+-+The+Reagent+Resource+Core&rft.au=Clark%2C+Adam+Michael&rft.aulast=Clark&rft.aufirst=Adam&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Seventeenth+Biennial+Meeting+of+the+International+Society+for+Molecular+Recognition+%28AFFINITY+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.affinitynyc.org/images/Affinity2007Schedule1.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sirt3: Modulator of Foxo3a Activity? T2 - 13th International Congress of Radiation Research (ICRR 2007) AN - 39498799; 4659929 DE: JF - 13th International Congress of Radiation Research (ICRR 2007) AU - Mishra, Mark V AU - Muldoon-Jacobs, Kristi AU - Nguyen, Phuongmai AU - Gius, David Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39498799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.atitle=Sirt3%3A+Modulator+of+Foxo3a+Activity%3F&rft.au=Mishra%2C+Mark+V%3BMuldoon-Jacobs%2C+Kristi%3BNguyen%2C+Phuongmai%3BGius%2C+David&rft.aulast=Mishra&rft.aufirst=Mark&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://171.65.6.67/icrr2007/pages_newbrwsrs/program_scientific_nb.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microarray Analysis of Radiation-Induced Genes in PC3 and DU 145 Cells after Single (10 Gy) and Fractionated (1 Gy and 2 Gy) Dose Irradiation. T2 - 13th International Congress of Radiation Research (ICRR 2007) AN - 39498576; 4659867 JF - 13th International Congress of Radiation Research (ICRR 2007) AU - Aryankalayil, Molykutty J AU - Palayoor, Sanjeewani T AU - Cerna, David AU - Falduto, Mike AU - Magnuson, Scott AU - Coleman, Norman Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Irradiation KW - Radiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39498576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.atitle=Microarray+Analysis+of+Radiation-Induced+Genes+in+PC3+and+DU+145+Cells+after+Single+%2810+Gy%29+and+Fractionated+%281+Gy+and+2+Gy%29+Dose+Irradiation.&rft.au=Aryankalayil%2C+Molykutty+J%3BPalayoor%2C+Sanjeewani+T%3BCerna%2C+David%3BFalduto%2C+Mike%3BMagnuson%2C+Scott%3BColeman%2C+Norman&rft.aulast=Aryankalayil&rft.aufirst=Molykutty&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://171.65.6.67/icrr2007/pages_newbrwsrs/program_scientific_nb.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Complexity of Phosphorylated H2AX Foci and DNA Repair Proteins at Ionizing Radiation Induced DNA Double-Strand Breaks in Mammalian Cells. T2 - 13th International Congress of Radiation Research (ICRR 2007) AN - 39485155; 4659661 JF - 13th International Congress of Radiation Research (ICRR 2007) AU - Nakamura, Asako AU - Bonner, William M Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Ionizing radiation KW - Double-strand break repair KW - Mammalian cells KW - DNA damage KW - DNA repair KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39485155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.atitle=The+Complexity+of+Phosphorylated+H2AX+Foci+and+DNA+Repair+Proteins+at+Ionizing+Radiation+Induced+DNA+Double-Strand+Breaks+in+Mammalian+Cells.&rft.au=Nakamura%2C+Asako%3BBonner%2C+William+M&rft.aulast=Nakamura&rft.aufirst=Asako&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://171.65.6.67/icrr2007/pages_newbrwsrs/program_scientific_nb.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Metabolomics as a Tool for Understanding the Cellular Stress Response of TK6 Cells Following Ionizing Radiation Exposure. T2 - 13th International Congress of Radiation Research (ICRR 2007) AN - 39484911; 4659601 JF - 13th International Congress of Radiation Research (ICRR 2007) AU - Patterson, Andrew D AU - Li, Henghong AU - Krausz, Kristopher W AU - Fornace Jr, Albert J AU - Gonzalez, Frank J AU - Idle, Jeffrey R Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Ionizing radiation KW - Stress KW - Metabolomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39484911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.atitle=Metabolomics+as+a+Tool+for+Understanding+the+Cellular+Stress+Response+of+TK6+Cells+Following+Ionizing+Radiation+Exposure.&rft.au=Patterson%2C+Andrew+D%3BLi%2C+Henghong%3BKrausz%2C+Kristopher+W%3BFornace+Jr%2C+Albert+J%3BGonzalez%2C+Frank+J%3BIdle%2C+Jeffrey+R&rft.aulast=Patterson&rft.aufirst=Andrew&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://171.65.6.67/icrr2007/pages_newbrwsrs/program_scientific_nb.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Speed of DNA Double-Strand Break Processing Depends on Age. T2 - 13th International Congress of Radiation Research (ICRR 2007) AN - 39464258; 4659463 JF - 13th International Congress of Radiation Research (ICRR 2007) AU - Sedelnikova, Olga AU - Redon, Christophe AU - Horikawa, Izumi AU - Zimonjic, Drazen AU - Popescu, Nicholas AU - Bonner, William Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - DNA damage KW - Age KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39464258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.atitle=Speed+of+DNA+Double-Strand+Break+Processing+Depends+on+Age.&rft.au=Sedelnikova%2C+Olga%3BRedon%2C+Christophe%3BHorikawa%2C+Izumi%3BZimonjic%2C+Drazen%3BPopescu%2C+Nicholas%3BBonner%2C+William&rft.aulast=Sedelnikova&rft.aufirst=Olga&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://171.65.6.67/icrr2007/pages_newbrwsrs/program_scientific_nb.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Guggulsterone Mediated Enhancement of Radiation Response. T2 - 13th International Congress of Radiation Research (ICRR 2007) AN - 39455622; 4659498 JF - 13th International Congress of Radiation Research (ICRR 2007) AU - Choudhuri, Rajani AU - DeGraff, William AU - Mitchell, James B AU - Cook, John A Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Radiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39455622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.atitle=Guggulsterone+Mediated+Enhancement+of+Radiation+Response.&rft.au=Choudhuri%2C+Rajani%3BDeGraff%2C+William%3BMitchell%2C+James+B%3BCook%2C+John+A&rft.aulast=Choudhuri&rft.aufirst=Rajani&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://171.65.6.67/icrr2007/pages_newbrwsrs/program_scientific_nb.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microarrays for Analysis and Detection of Microbial Pathogens and Their Toxins T2 - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AN - 39440242; 4647962 JF - 94th Annual Meeting of the International Association for Food Protection (IAFP 2007) AU - Rasooly, Avraham Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Pathogens KW - Toxins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39440242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.atitle=Microarrays+for+Analysis+and+Detection+of+Microbial+Pathogens+and+Their+Toxins&rft.au=Rasooly%2C+Avraham&rft.aulast=Rasooly&rft.aufirst=Avraham&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=94th+Annual+Meeting+of+the+International+Association+for+Food+Protection+%28IAFP+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.foodprotection.org/meetingsEducation/IAFP%202007/2007%20Pro gram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Iodine-125 Radioprobing of Intramolecular Quadruplex Conformation of Human Telomeric DNA: Effects of Flanking Sequences, Ionic Conditions and Quadruplex-Specific Drugs. T2 - 13th International Congress of Radiation Research (ICRR 2007) AN - 39433769; 4660005 JF - 13th International Congress of Radiation Research (ICRR 2007) AU - Gaynutdinov, Timur I AU - Neumann, Ronald D AU - Panyutin, Igor G Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Drugs KW - Conformation KW - Nucleotide sequence KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39433769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.atitle=Iodine-125+Radioprobing+of+Intramolecular+Quadruplex+Conformation+of+Human+Telomeric+DNA%3A+Effects+of+Flanking+Sequences%2C+Ionic+Conditions+and+Quadruplex-Specific+Drugs.&rft.au=Gaynutdinov%2C+Timur+I%3BNeumann%2C+Ronald+D%3BPanyutin%2C+Igor+G&rft.aulast=Gaynutdinov&rft.aufirst=Timur&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://171.65.6.67/icrr2007/pages_newbrwsrs/program_scientific_nb.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single Versus Fractionated Doses of Radiation Lead to Differences in Gene Expression in Human Tumor Cell Lines. T2 - 13th International Congress of Radiation Research (ICRR 2007) AN - 39423027; 4660105 JF - 13th International Congress of Radiation Research (ICRR 2007) AU - Cook, John A AU - Tsai, Mong-Hsun AU - Chandramouli, Gadisetti V.R. AU - DeGraff, William AU - Coleman, C Norman AU - Chuang, Eric Y AU - Mitchell, James B Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Gene expression KW - Radiation KW - Tumor cell lines KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39423027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.atitle=Single+Versus+Fractionated+Doses+of+Radiation+Lead+to+Differences+in+Gene+Expression+in+Human+Tumor+Cell+Lines.&rft.au=Cook%2C+John+A%3BTsai%2C+Mong-Hsun%3BChandramouli%2C+Gadisetti+V.R.%3BDeGraff%2C+William%3BColeman%2C+C+Norman%3BChuang%2C+Eric+Y%3BMitchell%2C+James+B&rft.aulast=Cook&rft.aufirst=John&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://171.65.6.67/icrr2007/pages_newbrwsrs/program_scientific_nb.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Base Damage Near Double-Strand Break Ends Affects Rejoining Efficiency and the Chronology of Repair Events for These Lesions. T2 - 13th International Congress of Radiation Research (ICRR 2007) AN - 39422713; 4660011 JF - 13th International Congress of Radiation Research (ICRR 2007) AU - Purkayastha, Shubhadeep AU - Datta, Kamal AU - Neumann, Ronald D AU - Winters, Thomas A Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Lesions KW - Double-strand break repair KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39422713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.atitle=Base+Damage+Near+Double-Strand+Break+Ends+Affects+Rejoining+Efficiency+and+the+Chronology+of+Repair+Events+for+These+Lesions.&rft.au=Purkayastha%2C+Shubhadeep%3BDatta%2C+Kamal%3BNeumann%2C+Ronald+D%3BWinters%2C+Thomas+A&rft.aulast=Purkayastha&rft.aufirst=Shubhadeep&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://171.65.6.67/icrr2007/pages_newbrwsrs/program_scientific_nb.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Radiation Metabolomics Permits Discovery of Mouse Urinary Biomarkers for Gamma Radiation Exposure. T2 - 13th International Congress of Radiation Research (ICRR 2007) AN - 39419746; 4659948 JF - 13th International Congress of Radiation Research (ICRR 2007) AU - Tyburski, John B AU - Slavik, Josef AU - Krausz, Kristopher W AU - Doiron, Kathryn AU - Lanz, Christian AU - Fornace Jr, Albert J AU - Gonzalez, Frank J AU - Idle, Jeffrey R Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - gamma Radiation KW - Bioindicators KW - Urine KW - Metabolomics KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39419746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.atitle=Radiation+Metabolomics+Permits+Discovery+of+Mouse+Urinary+Biomarkers+for+Gamma+Radiation+Exposure.&rft.au=Tyburski%2C+John+B%3BSlavik%2C+Josef%3BKrausz%2C+Kristopher+W%3BDoiron%2C+Kathryn%3BLanz%2C+Christian%3BFornace+Jr%2C+Albert+J%3BGonzalez%2C+Frank+J%3BIdle%2C+Jeffrey+R&rft.aulast=Tyburski&rft.aufirst=John&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://171.65.6.67/icrr2007/pages_newbrwsrs/program_scientific_nb.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Projected Update of the National Institutes of Health Radioepidemiological Tables and Interactive Radioepidemiological Program (IREP). T2 - 13th International Congress of Radiation Research (ICRR 2007) AN - 39418937; 4659526 DE: JF - 13th International Congress of Radiation Research (ICRR 2007) AU - Land, Charles E AU - Gilbert, Ethel S AU - Kwon, Deukwoo AU - Hoffman, F Owen AU - Iulian, Apostoaei AU - Thomas, Brian AU - Kocher, David C Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39418937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.atitle=Projected+Update+of+the+National+Institutes+of+Health+Radioepidemiological+Tables+and+Interactive+Radioepidemiological+Program+%28IREP%29.&rft.au=Land%2C+Charles+E%3BGilbert%2C+Ethel+S%3BKwon%2C+Deukwoo%3BHoffman%2C+F+Owen%3BIulian%2C+Apostoaei%3BThomas%2C+Brian%3BKocher%2C+David+C&rft.aulast=Land&rft.aufirst=Charles&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://171.65.6.67/icrr2007/pages_newbrwsrs/program_scientific_nb.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cancer Risks from Radiation Exposure in the Former Soviet Union. T2 - 13th International Congress of Radiation Research (ICRR 2007) AN - 39378370; 4659300 JF - 13th International Congress of Radiation Research (ICRR 2007) AU - Ron, Elaine Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Cancer KW - Radiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39378370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.atitle=Cancer+Risks+from+Radiation+Exposure+in+the+Former+Soviet+Union.&rft.au=Ron%2C+Elaine&rft.aulast=Ron&rft.aufirst=Elaine&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://171.65.6.67/icrr2007/pages_newbrwsrs/program_scientific_nb.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Environmental Radiation and Breast Cancer Incidence in the Techa River Cohort. T2 - 13th International Congress of Radiation Research (ICRR 2007) AN - 39372885; 4659521 JF - 13th International Congress of Radiation Research (ICRR 2007) AU - Ostroumova, Evgenia AU - Preston, Dale AU - Ron, Elaine AU - Krestinina, Ludmila AU - Davis, Faith AU - Akleyev, Alexander Y1 - 2007/07/08/ PY - 2007 DA - 2007 Jul 08 KW - Russia, Chelyabinskaya, Techa R. KW - Breast cancer KW - Radiation KW - Rivers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39372885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.atitle=Environmental+Radiation+and+Breast+Cancer+Incidence+in+the+Techa+River+Cohort.&rft.au=Ostroumova%2C+Evgenia%3BPreston%2C+Dale%3BRon%2C+Elaine%3BKrestinina%2C+Ludmila%3BDavis%2C+Faith%3BAkleyev%2C+Alexander&rft.aulast=Ostroumova&rft.aufirst=Evgenia&rft.date=2007-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Congress+of+Radiation+Research+%28ICRR+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://171.65.6.67/icrr2007/pages_newbrwsrs/program_scientific_nb.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Antifungal Effect of Litchi chinensis Sonn. Ethanolic Extracts Against Tree Pathogenic Fungi T2 - 2007 Joint Congress of the Botanical Society of America and American Society of Plant Biologists (Botany 2007 - Plant Biology 2007) AN - 39373671; 4609062 JF - 2007 Joint Congress of the Botanical Society of America and American Society of Plant Biologists (Botany 2007 - Plant Biology 2007) AU - Yen, Tsair-Bor AU - Su, Yu-Ho AU - Chiang, Yu-Chung AU - Chou, Chang-Hung Y1 - 2007/07/07/ PY - 2007 DA - 2007 Jul 07 KW - Fungi KW - Trees KW - Fungicides KW - Litchi chinensis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39373671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Joint+Congress+of+the+Botanical+Society+of+America+and+American+Society+of+Plant+Biologists+%28Botany+2007+-+Plant+Biology+2007%29&rft.atitle=Evaluation+of+Antifungal+Effect+of+Litchi+chinensis+Sonn.+Ethanolic+Extracts+Against+Tree+Pathogenic+Fungi&rft.au=Yen%2C+Tsair-Bor%3BSu%2C+Yu-Ho%3BChiang%2C+Yu-Chung%3BChou%2C+Chang-Hung&rft.aulast=Yen&rft.aufirst=Tsair-Bor&rft.date=2007-07-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Joint+Congress+of+the+Botanical+Society+of+America+and+American+Society+of+Plant+Biologists+%28Botany+2007+-+Plant+Biology+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.2007.botanyconference.org/engine/search/index.php?func=Abst ractTitle<r=All LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Altered Binding of Purified Type 2M Vicenza Von Willebrand Factor to Platelet Receptor AlphaIIbbeta3 and GPIb-V-IX Complex T2 - XXIst Congress of the International Society on Thrombosis and Haemostasis (ISTH 2007) AN - 39452291; 4643744 JF - XXIst Congress of the International Society on Thrombosis and Haemostasis (ISTH 2007) AU - Cozzi, M R AU - Castaman, G AU - Mazzucato, M AU - Steffan, A AU - Battiston, M AU - Rodeghiero, F AU - De Marco, L Y1 - 2007/07/06/ PY - 2007 DA - 2007 Jul 06 KW - Von Willebrand factor KW - Platelets KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39452291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXIst+Congress+of+the+International+Society+on+Thrombosis+and+Haemostasis+%28ISTH+2007%29&rft.atitle=Altered+Binding+of+Purified+Type+2M+Vicenza+Von+Willebrand+Factor+to+Platelet+Receptor+AlphaIIbbeta3+and+GPIb-V-IX+Complex&rft.au=Cozzi%2C+M+R%3BCastaman%2C+G%3BMazzucato%2C+M%3BSteffan%2C+A%3BBattiston%2C+M%3BRodeghiero%2C+F%3BDe+Marco%2C+L&rft.aulast=Cozzi&rft.aufirst=M&rft.date=2007-07-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXIst+Congress+of+the+International+Society+on+Thrombosis+and+Haemostasis+%28ISTH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://isth2007.abstractsondemand.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Flow Cytometric Method for the Detection of Reticulated Platelets by an Anti-Bromodeoxyuridine Monoclonal Antibody T2 - XXIst Congress of the International Society on Thrombosis and Haemostasis (ISTH 2007) AN - 39438607; 4644360 JF - XXIst Congress of the International Society on Thrombosis and Haemostasis (ISTH 2007) AU - Gasparollo, A AU - Steffan, A AU - Tassan, R AU - Degan, M AU - Gattei, V AU - De Marco, L Y1 - 2007/07/06/ PY - 2007 DA - 2007 Jul 06 KW - Monoclonal antibodies KW - Flow cytometry KW - Platelets KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39438607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXIst+Congress+of+the+International+Society+on+Thrombosis+and+Haemostasis+%28ISTH+2007%29&rft.atitle=A+Novel+Flow+Cytometric+Method+for+the+Detection+of+Reticulated+Platelets+by+an+Anti-Bromodeoxyuridine+Monoclonal+Antibody&rft.au=Gasparollo%2C+A%3BSteffan%2C+A%3BTassan%2C+R%3BDegan%2C+M%3BGattei%2C+V%3BDe+Marco%2C+L&rft.aulast=Gasparollo&rft.aufirst=A&rft.date=2007-07-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXIst+Congress+of+the+International+Society+on+Thrombosis+and+Haemostasis+%28ISTH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://isth2007.abstractsondemand.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cerebrovascular Thrombosis during Estroprogestinic Therapy in a Young Woman T2 - XXIst Congress of the International Society on Thrombosis and Haemostasis (ISTH 2007) AN - 39416958; 4644734 JF - XXIst Congress of the International Society on Thrombosis and Haemostasis (ISTH 2007) AU - Durante, C AU - Steffan, A Y1 - 2007/07/06/ PY - 2007 DA - 2007 Jul 06 KW - Thrombosis KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39416958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXIst+Congress+of+the+International+Society+on+Thrombosis+and+Haemostasis+%28ISTH+2007%29&rft.atitle=Cerebrovascular+Thrombosis+during+Estroprogestinic+Therapy+in+a+Young+Woman&rft.au=Durante%2C+C%3BSteffan%2C+A&rft.aulast=Durante&rft.aufirst=C&rft.date=2007-07-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXIst+Congress+of+the+International+Society+on+Thrombosis+and+Haemostasis+%28ISTH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://isth2007.abstractsondemand.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Toward Understanding the Cationicity of Defensins: ARG AND LYS VERSUS THEIR NONCODED ANALOGS AN - 19785034; 7530947 AB - Human defensins are a family of small antimicrobial proteins found predominantly in leukocytes and epithelial cells that play important roles in the innate and adaptive immune defense against microbial infection. The most distinct molecular feature of defensins is cationicity, manifested by abundant Arg and/or Lys residues in their sequences. Sequence analysis indicates that Arg is strongly selected over Lys in alpha -defensins but not in beta -defensins. To understand this Arg/Lys disparity in defensins, we chemically synthesized human alpha -defensin 1 (HNP1) and several HNP1 analogs where three Arg residues were replaced by each of the following six alpha -amino acids: Lys, ornithine (Orn), diaminobutyric acid (Dab), diaminopropionic acid (Dap), N,N-dimethyl-Lys ( super(diMe)Lys), and homo-Arg ( super(homo)Arg). In addition, we prepared human beta -defensin 1 (hBD1) and super(Lys arrow right Arg)hBD1 in which all four Lys residues were substituted for Arg. Bactericidal activity assays revealed the following. 1) Arg-containing HNP1 and super(Lys arrow right Arg)hBD1 are functionally better than Lys-HNP1 and hBD1, respectively; the difference between Arg and Lys is more evident in the alpha -defensin than in the beta -defensin and is more evident at low salt concentrations than at high salt concentrations. 2) For HNP1, the Arg/Lys disparity is much more pronounced with Staphylococcus aureus than with Escherichia coli, and the Arg-rich HNP1 kills bacteria faster than its Lys-rich analog. 3) Arg and Lys appear to have optimal chain lengths for bacterial killing as shortening Lys or lengthening Arg in HNP1 invariably becomes functionally deleterious. Our findings provide insights into the Arg/Lys disparity in defensins, and shed light on the cationicity of defensins with respect to their antimicrobial activity and specificity. JF - Journal of Biological Chemistry AU - Zou, Guozhang AU - de Leeuw, Erik AU - Li, Chong AU - Pazgier, Marzena AU - Li, Changqing AU - Zeng, Pengyun AU - Lu, Wei-Yue AU - Lubkowski, Jacek AU - Lu, Wuyuan AD - Institute of Human Virology, University of Maryland Biotechnology Institute, Baltimore, Maryland 21201, Fudan-PharmCo. Drug Target Research Center, School of Pharmacy, Fudan University, Shanghai 200032, China, and the Macromolecular Assembly Structure and Cell Signaling Section, NCI, National Institutes of Health, Frederick, Maryland 21702 Y1 - 2007/07/06/ PY - 2007 DA - 2007 Jul 06 SP - 19653 EP - 19665 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 27 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Epithelial cells KW - Antimicrobial activity KW - Arginine KW - Leukocytes KW - Lysine KW - Infection KW - Antimicrobial agents KW - Salts KW - Defensins KW - Acids KW - Escherichia coli KW - ornithine KW - Staphylococcus aureus KW - Bactericidal activity KW - F 06960:Molecular Immunology KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19785034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Toward+Understanding+the+Cationicity+of+Defensins%3A+ARG+AND+LYS+VERSUS+THEIR+NONCODED+ANALOGS&rft.au=Zou%2C+Guozhang%3Bde+Leeuw%2C+Erik%3BLi%2C+Chong%3BPazgier%2C+Marzena%3BLi%2C+Changqing%3BZeng%2C+Pengyun%3BLu%2C+Wei-Yue%3BLubkowski%2C+Jacek%3BLu%2C+Wuyuan&rft.aulast=Zou&rft.aufirst=Guozhang&rft.date=2007-07-06&rft.volume=282&rft.issue=27&rft.spage=19653&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Salts; Epithelial cells; Antimicrobial activity; Defensins; Arginine; Acids; Leukocytes; ornithine; Lysine; Infection; Bactericidal activity; Antimicrobial agents; Escherichia coli; Staphylococcus aureus ER - TY - JOUR T1 - Deleted in liver cancer 3 (DLC-3), a novel Rho GTPase-activating protein, is downregulated in cancer and inhibits tumor cell growth. AN - 70695875; 17297465 AB - Two related Rho GTPase-activating proteins, DLC-1 (deleted in liver cancer 1) and DLC-2, are emerging as bona fide tumor suppressor genes that inhibit cancer cell growth. In this report, we characterized a gene on chromosome Xq13 that encodes DLC-3 (also known as KIAA0189 and STARD8), a third member of the DLC family. The DLC-3 gene has transcripts with alternative 5' ends, one of which, DLC-3alpha, encodes an 1103-amino acid polypeptide highly similar to DLC-1 and DLC-2. A second isoform (DLC-3beta) would yield a protein lacking the N-terminal sterile alpha motif domain. The DLC-3 gene is widely expressed in normal tissues, but DLC-3 mRNA levels were low or absent in a significant number of breast, ovarian, liver and prostate cancer cell lines. Using a cancer profiling array to compare matched tumor and normal human tissues, downregulation of DLC-3 mRNA was observed in kidney, lung, ovarian, uterine and breast cancer samples. By quantitative reverse transcriptase-polymerase chain reaction, DLC-3 expression was reduced in primary prostate carcinomas relative to normal prostate tissue. Transfection of human breast and prostate cancer cells with a DLC-3alpha expression vector inhibited cell proliferation, colony formation and growth in soft agar. These results indicate that deregulation of DLC-3 may contribute to breast and prostate tumorigenesis. JF - Oncogene AU - Durkin, M E AU - Ullmannova, V AU - Guan, M AU - Popescu, N C AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2007/07/05/ PY - 2007 DA - 2007 Jul 05 SP - 4580 EP - 4589 VL - 26 IS - 31 SN - 0950-9232, 0950-9232 KW - DLC1 protein, human KW - 0 KW - GTPase-Activating Proteins KW - Tumor Suppressor Proteins KW - rho GTPase-activating protein KW - Index Medicus KW - Prostatic Neoplasms -- metabolism KW - Genes, Tumor Suppressor KW - Humans KW - Prostate -- metabolism KW - Breast Neoplasms -- metabolism KW - Amino Acid Sequence KW - Reverse Transcriptase Polymerase Chain Reaction KW - Cell Proliferation KW - Down-Regulation KW - Molecular Sequence Data KW - Breast -- metabolism KW - Female KW - Male KW - GTPase-Activating Proteins -- metabolism KW - Tumor Suppressor Proteins -- genetics KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70695875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Deleted+in+liver+cancer+3+%28DLC-3%29%2C+a+novel+Rho+GTPase-activating+protein%2C+is+downregulated+in+cancer+and+inhibits+tumor+cell+growth.&rft.au=Durkin%2C+M+E%3BUllmannova%2C+V%3BGuan%2C+M%3BPopescu%2C+N+C&rft.aulast=Durkin&rft.aufirst=M&rft.date=2007-07-05&rft.volume=26&rft.issue=31&rft.spage=4580&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-30 N1 - Date created - 2007-07-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - New cell lines from mouse epiblast share defining features with human embryonic stem cells AN - 19776769; 7491363 AB - The application of human embryonic stem (ES) cells in medicine and biology has an inherent reliance on understanding the starting cell population. Human ES cells differ from mouse ES cells and the specific embryonic origin of both cell types is unclear. Previous work suggested that mouse ES cells could only be obtained from the embryo before implantation in the uterus. Here we show that cell lines can be derived from the epiblast, a tissue of the post-implantation embryo that generates the embryo proper. These cells, which we refer to as EpiSCs (post-implantation epiblast-derived stem cells), express transcription factors known to regulate pluripotency, maintain their genomic integrity, and robustly differentiate into the major somatic cell types as well as primordial germ cells. The EpiSC lines are distinct from mouse ES cells in their epigenetic state and the signals controlling their differentiation. Furthermore, EpiSC and human ES cells share patterns of gene expression and signalling responses that normally function in the epiblast. These results show that epiblast cells can be maintained as stable cell lines and interrogated to understand how pluripotent cells generate distinct fates during early development. JF - Nature AU - Tesar, Paul J AU - Chenoweth, Josh G AU - Brook, Frances A AU - Davies, Timothy J AU - Evans, Edward P AU - Mack, David L AU - Gardner, Richard L AU - McKay, Ronald DG AD - Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA PY - 2007 SP - 196 EP - 199 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 448 IS - 7149 SN - 0028-0836, 0028-0836 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Differentiation KW - Stem cells KW - Uterus KW - Embryo cells KW - epigenetics KW - Transcription factors KW - Germ cells KW - genomics KW - Somatic cells KW - Signal transduction KW - G 07730:Development & Cell Cycle KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19776769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=New+cell+lines+from+mouse+epiblast+share+defining+features+with+human+embryonic+stem+cells&rft.au=Tesar%2C+Paul+J%3BChenoweth%2C+Josh+G%3BBrook%2C+Frances+A%3BDavies%2C+Timothy+J%3BEvans%2C+Edward+P%3BMack%2C+David+L%3BGardner%2C+Richard+L%3BMcKay%2C+Ronald+DG&rft.aulast=Tesar&rft.aufirst=Paul&rft.date=2007-07-05&rft.volume=448&rft.issue=7149&rft.spage=196&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/10.1038%2Fnature05972 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Gene expression; Differentiation; Uterus; Stem cells; Embryo cells; epigenetics; Transcription factors; Germ cells; genomics; Somatic cells; Signal transduction DO - http://dx.doi.org/10.1038/nature05972 ER - TY - JOUR T1 - Toward a Systems Engineering Approach to Cancer Drug Delivery AN - 20005626; 7531897 JF - Journal of the National Cancer Institute AU - Dreher, Matthew R AU - Chilkoti, Ashutosh AD - Diagnostic Radiology Department, Clinical Center, National Institutes of Health, Bethesda, MD (MRD) Y1 - 2007/07/04/ PY - 2007 DA - 2007 Jul 04 SP - 983 EP - 985 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 13 SN - 0027-8874, 0027-8874 KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Cancer KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20005626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Toward+a+Systems+Engineering+Approach+to+Cancer+Drug+Delivery&rft.au=Dreher%2C+Matthew+R%3BChilkoti%2C+Ashutosh&rft.aulast=Dreher&rft.aufirst=Matthew&rft.date=2007-07-04&rft.volume=99&rft.issue=13&rft.spage=983&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Drug delivery; Cancer ER - TY - JOUR T1 - Cannabinoid concentrations in hair from documented cannabis users AN - 19721538; 7521093 AB - Fifty-three head hair specimens were collected from 38 males with a history of cannabis use documented by questionnaire, urinalysis and controlled, double blind administration of Delta super(9)-tetrahydrocannabinol (THC) in an institutional review board approved protocol. The subjects completed a questionnaire indicating daily cannabis use (N = 18) or non-daily use, i.e. one to five cannabis cigarettes per week (N = 20). Drug use was also documented by a positive cannabinoid urinalysis, a hair specimen was collected from each subject and they were admitted to a closed research unit. Additional hair specimens were collected following smoking of two 2.7% THC cigarettes (N = 13) or multiple oral doses totaling 116 mg THC (N = 2). Cannabinoid concentrations in all hair specimens were determined by ELISA and GCMSMS. Pre- and post-dose detection rates did not differ statistically, therefore, all 53 specimens were considered as one group for further comparisons. Nineteen specimens (36%) had no detectable THC or 11-nor-9-carboxy-THC (THCCOOH) at the GCMSMS limits of quantification (LOQ) of 1.0 and 0.1 pg/mg hair, respectively. Two specimens (3.8%) had measurable THC only, 14 (26%) THCCOOH only, and 18 (34%) both cannabinoids. Detection rates were significantly different (p 0.3, Fisher's exact test). For specimens with detectable cannabinoids, concentrations ranged from 3.4 to >100 pg THC/mg and 0.10 to 7.3 pg THCCOOH/mg hair. THC and THCCOOH concentrations were positively correlated (r = 0.38, p < 0.01, Pearson's product moment correlation). Using an immunoassay cutoff concentration of 5 pg THC equiv./mg hair, 83% of specimens that screened positive were confirmed by GCMSMS at a cutoff concentration of 0.1 pg THCCOOH/mg hair. JF - Forensic Science International AU - Huestis, MA AU - Gustafson, R A AU - Moolchan, E T AU - Barnes, A AU - Bourland, JA AU - Sweeney, SA AU - Hayes, E F AU - Carpenter, P M AU - Smith, M L AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, United States, mhuestis@intra.nida.nih.gov Y1 - 2007/07/04/ PY - 2007 DA - 2007 Jul 04 SP - 129 EP - 136 VL - 169 IS - 2-3 SN - 0379-0738, 0379-0738 KW - Toxicology Abstracts KW - Tetrahydrocannabinol KW - Inventories KW - Smoking KW - Enzyme-linked immunosorbent assay KW - Cannabinoids KW - Cigarettes KW - Cannabis KW - Drug abuse KW - Urinalysis KW - Hair KW - Immunoassays KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19721538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Forensic+Science+International&rft.atitle=Cannabinoid+concentrations+in+hair+from+documented+cannabis+users&rft.au=Huestis%2C+MA%3BGustafson%2C+R+A%3BMoolchan%2C+E+T%3BBarnes%2C+A%3BBourland%2C+JA%3BSweeney%2C+SA%3BHayes%2C+E+F%3BCarpenter%2C+P+M%3BSmith%2C+M+L&rft.aulast=Huestis&rft.aufirst=MA&rft.date=2007-07-04&rft.volume=169&rft.issue=2-3&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Forensic+Science+International&rft.issn=03790738&rft_id=info:doi/10.1016%2Fj.forsciint.2006.08.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Tetrahydrocannabinol; Smoking; Inventories; Enzyme-linked immunosorbent assay; Cigarettes; Cannabinoids; Cannabis; Urinalysis; Drug abuse; Immunoassays; Hair DO - http://dx.doi.org/10.1016/j.forsciint.2006.08.005 ER - TY - JOUR T1 - Collaboration between the ClpB AAA+ remodeling protein and the DnaK chaperone system. AN - 70693894; 17545305 AB - ClpB and Hsp104, members of the AAA+ superfamily of proteins, protect cells from the devastating effects of protein inactivation and aggregation that arise after extreme heat stress. They exist as a hexameric ring and contain two nucleotide-binding sites per monomer. ClpB and Hsp104 are able to dissolve protein aggregates in conjunction with the DnaK/Hsp70 chaperone system, although the roles of the individual chaperones in disaggregation are not well understood. In the absence of the DnaK/Hsp70 system, ClpB and Hsp104 alone are able to perform protein remodeling when their ATPase activity is asymmetrically slowed either by providing a mixture of ATP and ATP gamma S, a nonphysiological and slowly hydrolyzed ATP analog, or by inactivating one of the two nucleotide-binding domains by mutation. To gain insight into the roles of ClpB and the DnaK system in protein remodeling, we tested whether there was a further stimulation by the DnaK chaperone system under conditions that elicited remodeling activity by ClpB alone. Our results demonstrate that ClpB and the DnaK system act synergistically to remodel proteins and dissolve aggregates. The results further show that ATP is required and that both nucleotide-binding sites of ClpB must be able to hydrolyze ATP to permit functional collaboration between ClpB and the DnaK system. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Doyle, Shannon M AU - Hoskins, Joel R AU - Wickner, Sue AD - Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/07/03/ PY - 2007 DA - 2007 Jul 03 SP - 11138 EP - 11144 VL - 104 IS - 27 SN - 0027-8424, 0027-8424 KW - ClpB protein, E coli KW - 0 KW - Escherichia coli Proteins KW - HSP70 Heat-Shock Proteins KW - Heat-Shock Proteins KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Adenosine Triphosphatases KW - EC 3.6.1.- KW - dnaK protein, E coli KW - Index Medicus KW - Adenosine Triphosphate -- physiology KW - Green Fluorescent Proteins -- chemistry KW - Drug Synergism KW - Green Fluorescent Proteins -- metabolism KW - Adenosine Triphosphate -- chemistry KW - Escherichia coli Proteins -- chemistry KW - HSP70 Heat-Shock Proteins -- chemistry KW - HSP70 Heat-Shock Proteins -- physiology KW - Heat-Shock Proteins -- physiology KW - Adenosine Triphosphatases -- metabolism KW - Escherichia coli -- chemistry KW - Escherichia coli -- physiology KW - Adenosine Triphosphatases -- chemistry KW - Escherichia coli Proteins -- physiology KW - Heat-Shock Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70693894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Collaboration+between+the+ClpB+AAA%2B+remodeling+protein+and+the+DnaK+chaperone+system.&rft.au=Doyle%2C+Shannon+M%3BHoskins%2C+Joel+R%3BWickner%2C+Sue&rft.aulast=Doyle&rft.aufirst=Shannon&rft.date=2007-07-03&rft.volume=104&rft.issue=27&rft.spage=11138&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-26 N1 - Date created - 2007-07-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8898-903 [10922052] Nature. 1999 Sep 2;401(6748):90-3 [10485712] Cell. 2000 Nov 10;103(4):633-43 [11106733] Mol Cell. 2002 Mar;9(3):673-83 [11931773] Mol Cell. 2002 Apr;9(4):751-60 [11983167] Biochemistry. 2002 Sep 17;41(37):11277-83 [12220194] J Biol Chem. 2002 Nov 29;277(48):46743-52 [12205096] J Biol Chem. 2003 May 16;278(20):17615-24 [12624113] Nucleic Acids Res. 2003 Jul 1;31(13):3381-5 [12824332] J Biol Chem. 2003 Aug 29;278(35):32608-17 [12805357] Cell. 2003 Oct 17;115(2):229-40 [14567920] J Biol Chem. 2003 Dec 12;278(50):50664-70 [14514695] J Mol Biol. 2004 Feb 6;336(1):275-85 [14741222] Protein Sci. 2004 Mar;13(3):567-74 [14978298] Science. 2004 Jun 18;304(5678):1793-7 [15155912] Nat Struct Mol Biol. 2004 Jul;11(7):607-15 [15208691] Anal Biochem. 1984 May 1;138(2):416-20 [6742419] Science. 1990 Jun 1;248(4959):1112-5 [2188365] Nature. 1991 Mar 14;350(6314):165-7 [2005967] J Bacteriol. 1991 Jul;173(14):4254-62 [2066329] Proc Natl Acad Sci U S A. 1991 Sep 15;88(18):7903-7 [1896443] J Biol Chem. 1993 Dec 5;268(34):25296-301 [8244960] Nature. 1994 Dec 1;372(6505):475-8 [7984243] Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12218-22 [7991609] Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13732-7 [10570141] EMBO J. 1999 Dec 15;18(24):6934-49 [10601016] J Biol Chem. 2000 Jul 14;275(28):21107-13 [10801805] Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8892-7 [10922051] EMBO J. 1997 Apr 1;16(7):1501-7 [9130695] J Biol Chem. 1998 May 15;273(20):12476-81 [9575205] Cell. 1998 Jul 10;94(1):73-82 [9674429] Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12135-40 [9770452] Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7184-9 [10377389] J Biol Chem. 1999 Oct 1;274(40):28083-6 [10497158] Cell. 2004 Nov 24;119(5):653-65 [15550247] FEBS Lett. 2004 Dec 17;578(3):351-6 [15589844] Nat Rev Mol Cell Biol. 2005 Jul;6(7):519-29 [16072036] J Biol Chem. 2005 Oct 14;280(41):34940-5 [16076845] Arch Biochem Biophys. 2005 Dec 1;444(1):61-5 [16289019] J Biol Chem. 2006 Mar 17;281(11):7022-9 [16415353] Annu Rev Biophys Biomol Struct. 2006;35:93-114 [16689629] Mol Cell. 2006 Aug 4;23(3):425-38 [16885031] Mol Microbiol. 2006 Sep;61(5):1094-100 [16879409] Mol Cell. 2007 Jan 26;25(2):247-60 [17244532] Mol Cell. 2007 Jan 26;25(2):261-71 [17244533] Nat Struct Mol Biol. 2007 Feb;14(2):114-22 [17259993] J Biol Chem. 2000 Nov 10;275(45):35361-7 [10952988] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ceramide transfer protein function is essential for normal oxidative stress response and lifespan. AN - 70675755; 17592126 AB - Ceramide transfer protein (CERT) transfers ceramide from the endoplasmic reticulum to the Golgi complex, a process critical in synthesis and maintenance of normal levels of sphingolipids in mammalian cells. However, how its function is integrated into development and physiology of the animal is less clear. Here, we report the in vivo consequences of loss of functional CERT protein. We generated Drosophila melanogaster mutant flies lacking a functional CERT (Dcert) protein using chemical mutagenesis and a Western blot-based genetic screen. The mutant flies die early between days 10 and 30, whereas controls lived between 75 and 90 days. They display >70% decrease in ceramide phosphoethanolamine (the sphingomyelin analog in Drosophila) and ceramide. These changes resulted in increased plasma membrane fluidity that renders them susceptible to reactive oxygen species and results in enhanced oxidative damage to cellular proteins. Consequently, the flies showed reduced thermal tolerance that was exacerbated with aging and metabolic compromise such as decreasing ATP and increasing glucose levels, reminiscent of premature aging. Our studies demonstrate that maintenance of physiological levels of ceramide phosphoethanolamine by CERT in vivo is required to prevent oxidative damages to cellular components that are critical for viability and normal lifespan of the animal. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Rao, Raghavendra Pralhada AU - Yuan, Changqing AU - Allegood, Jeremy C AU - Rawat, Satinder S AU - Edwards, Michael Beth AU - Wang, Xin AU - Merrill, Alfred H AU - Acharya, Usha AU - Acharya, Jairaj K AD - Laboratory of Cell and Developmental Signaling, National Cancer Institute Frederick, Frederick, MD 21702, USA. Y1 - 2007/07/03/ PY - 2007 DA - 2007 Jul 03 SP - 11364 EP - 11369 VL - 104 IS - 27 SN - 0027-8424, 0027-8424 KW - CERT protein, Drosophila KW - 0 KW - Carrier Proteins KW - Ceramides KW - Drosophila Proteins KW - Index Medicus KW - Animals KW - Animals, Genetically Modified KW - Oxidative Stress -- physiology KW - Drosophila melanogaster -- growth & development KW - Longevity -- genetics KW - Drosophila melanogaster -- genetics KW - Longevity -- physiology KW - Drosophila Proteins -- physiology KW - Ceramides -- metabolism KW - Carrier Proteins -- physiology KW - Oxidative Stress -- genetics KW - Drosophila Proteins -- genetics KW - Drosophila Proteins -- deficiency KW - Drosophila melanogaster -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70675755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Ceramide+transfer+protein+function+is+essential+for+normal+oxidative+stress+response+and+lifespan.&rft.au=Rao%2C+Raghavendra+Pralhada%3BYuan%2C+Changqing%3BAllegood%2C+Jeremy+C%3BRawat%2C+Satinder+S%3BEdwards%2C+Michael+Beth%3BWang%2C+Xin%3BMerrill%2C+Alfred+H%3BAcharya%2C+Usha%3BAcharya%2C+Jairaj+K&rft.aulast=Rao&rft.aufirst=Raghavendra&rft.date=2007-07-03&rft.volume=104&rft.issue=27&rft.spage=11364&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-26 N1 - Date created - 2007-07-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Anal Biochem. 2000 Feb 1;278(1):59-68 [10640354] J Neurosci. 2006 Nov 29;26(48):12408-14 [17135402] J Biol Chem. 2000 Sep 29;275(39):29938-45 [10882735] J Cell Biol. 2001 Dec 10;155(6):949-59 [11733544] Int J Biochem Cell Biol. 2002 Nov;34(11):1372-81 [12200032] J Neurosci. 2003 Feb 15;23(4):1276-86 [12598616] Radiat Res. 2003 Apr;159(4):471-83 [12643792] Prog Lipid Res. 2003 Jul;42(4):318-43 [12689622] Methods Mol Biol. 2000;99:15-24 [10909073] Trends Mol Med. 2003 Apr;9(4):169-76 [12727143] Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10219-24 [12923296] Dev Cell. 2003 Nov;5(5):811-6 [14602080] Nature. 2003 Dec 18;426(6968):803-9 [14685229] FASEB J. 2004 Mar;18(3):598-9 [14734639] J Biol Chem. 2004 Apr 30;279(18):18688-93 [14976195] J Comp Physiol Psychol. 1969 Jan;67(1):118-22 [5787804] Biochim Biophys Acta. 1984 Feb 9;792(2):123-9 [6365170] Mol Cell Biol. 1988 Feb;8(2):802-13 [2832737] FEBS Lett. 1990 Feb 12;261(1):155-7 [2155131] Biochim Biophys Acta. 1990 May 1;1044(1):1-12 [2187537] J Biol Chem. 1990 May 25;265(15):8650-7 [2187869] Biochim Biophys Acta. 1991 Mar 12;1082(2):113-25 [2007175] Free Radic Biol Med. 1991;11(1):81-128 [1937131] Adv Lipid Res. 1993;26:321-51 [8379457] Chem Phys Lipids. 1993 Sep;64(1-3):99-116 [8242843] Biochim Biophys Acta. 1995 Oct 4;1239(1):58-66 [7548145] Proc Natl Acad Sci U S A. 1996 May 14;93(10):5116-21 [8643537] Neuron. 1998 Jun;20(6):1219-29 [9655509] J Pharmacol Exp Ther. 1998 Oct;287(1):322-31 [9765353] J Biol Chem. 1998 Dec 11;273(50):33787-94 [9837968] J Cell Biol. 1999 Feb 22;144(4):673-85 [10037789] J Biol Chem. 1999 Apr 23;274(17):12049-54 [10207028] Comp Biochem Physiol B Biochem Mol Biol. 1999 Jan;122(1):83-8 [10327597] Cell Mol Life Sci. 2005 Jan;62(2):128-42 [15666085] J Biol Chem. 2005 Feb 25;280(8):6488-95 [15596449] Cell. 2005 Feb 25;120(4):483-95 [15734681] J Pharmacol Exp Ther. 2005 Apr;313(1):104-11 [15634942] EMBO J. 2005 Apr 6;24(7):1311-7 [15775985] Exp Gerontol. 2005 May;40(5):386-95 [15919590] Nat Neurosci. 2005 Nov;8(11):1577-85 [16222229] Dev Cell. 2005 Dec;9(6):843-54 [16326395] J Cell Biol. 2006 Apr 10;173(1):69-82 [16606691] Mol Cell Biochem. 2006 Jun;286(1-2):23-31 [16601923] J Cell Mol Med. 2006 Apr-Jun;10(2):389-406 [16796807] J Biol Chem. 2006 Oct 6;281(40):30279-88 [16895911] Chem Phys Lipids. 1999 Nov;102(1-2):29-34 [11001558] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prospective study of serum 25(OH)-vitamin D concentration and risk of oesophageal and gastric cancers AN - 19762529; 7577273 AB - We prospectively examined the relation between pretrial serum vitamin D status and risk of oesophageal and gastric cancers among subjects who developed cancer over 5.25 years of follow-up, including 545 oesophageal squamous cell carcinomas (ESCC), 353 gastric cardia adenocarcinomas, 81 gastric noncardia adenocarcinomas, and an age- and sex-stratified random sample of 1105 subjects. The distribution of serum 25(OH)D was calculated using the known sampling weights. For the cohort as a whole, the 25th, 50th, and 75th percentile concentrations of 25(OH)-vitamin D were 19.6, 31.9, and 48.7 nmol l super(-1), respectively, and we found that higher serum 25(OH)D concentrations were associated with monotonically increasing risk of ESCC in men, but not in women. Comparing men in the fourth quartile of serum 25(OH)D concentrations to those in the first, we found a hazard ratio (HR) (95% confidence interval (CI)) of 1.77 (1.16-2.70), P trend = 0.0033. The same comparison in women had a HR (95% CI) of 1.06 (0.71-1.59), P trend = 0.70. We found no associations for gastric cardia or noncardia adenocarcinoma. Among subjects with low vitamin D status, higher serum 25(OH)D concentrations were associated with significantly increased risk of ESCC in men, but not in women. Further refinements of the analysis did not suggest any factors, which could explain this unexpected result. JF - British Journal of Cancer AU - Chen, W AU - Dawsey, S M AU - Qiao, Y-L AU - Mark, S D AU - Dong, Z-W AU - Taylor, PR AU - Zhao, P AU - Abnet, C C AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, 6120 Executive Blvd, EPS/320, MSC 7232, Rockville, MD 20852, USA, abnetc@mail.nih.gov Y1 - 2007/07/02/ PY - 2007 DA - 2007 Jul 02 SP - 123 EP - 128 VL - 97 IS - 1 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - vitamins KW - Dietary supplements KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19762529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Prospective+study+of+serum+25%28OH%29-vitamin+D+concentration+and+risk+of+oesophageal+and+gastric+cancers&rft.au=Chen%2C+W%3BDawsey%2C+S+M%3BQiao%2C+Y-L%3BMark%2C+S+D%3BDong%2C+Z-W%3BTaylor%2C+PR%3BZhao%2C+P%3BAbnet%2C+C+C&rft.aulast=Chen&rft.aufirst=W&rft.date=2007-07-02&rft.volume=97&rft.issue=1&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6603834 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - vitamins; Dietary supplements; Cancer DO - http://dx.doi.org/10.1038/sj.bjc.6603834 ER - TY - JOUR T1 - Population models with singular equilibrium AN - 883036783; 15326427 AB - A class of models of biological population and communities with a singular equilibrium at the origin is analyzed; it is shown that these models can possess a dynamical regime of deterministic extinction, which is crucially important from the biological standpoint. This regime corresponds to the presence of a family of homoclinics to the origin, so-called elliptic sector. The complete analysis of possible topological structures in a neighborhood of the origin, as well as asymptotics to orbits tending to this point, is given. An algorithmic approach to analyze system behavior with parameter changes is presented. The developed methods and algorithm are applied to existing mathematical models of biological systems. In particular, we analyze a model of anticancer treatment with oncolytic viruses, a parasite-host interaction model, and a model of Chagas' disease. JF - Mathematical Biosciences AU - Berezovskaya, Faina S AU - Novozhilov, Artem S AU - Karev, Georgy P Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 270 EP - 299 PB - Elsevier B.V., Box 882 New York NY 10159 United States VL - 208 IS - 1 SN - 0025-5564, 0025-5564 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Ecology Abstracts; Biotechnology and Bioengineering Abstracts KW - Non-analytic equilibrium KW - Ratio-dependent response KW - Pathogen transmission KW - Elliptic sector KW - Population extinction KW - Mathematical models KW - Extinction KW - Viruses KW - Algorithms KW - Disease control KW - Oncolysis KW - Chagas' disease KW - Public health KW - Modelling KW - D 04030:Models, Methods, Remote Sensing KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883036783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mathematical+Biosciences&rft.atitle=Population+models+with+singular+equilibrium&rft.au=Berezovskaya%2C+Faina+S%3BNovozhilov%2C+Artem+S%3BKarev%2C+Georgy+P&rft.aulast=Berezovskaya&rft.aufirst=Faina&rft.date=2007-07-01&rft.volume=208&rft.issue=1&rft.spage=270&rft.isbn=&rft.btitle=&rft.title=Mathematical+Biosciences&rft.issn=00255564&rft_id=info:doi/10.1016%2Fj.mbs.2006.10.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Mathematical models; Viruses; Disease control; Modelling; Public health; Extinction; Algorithms; Oncolysis; Chagas' disease DO - http://dx.doi.org/10.1016/j.mbs.2006.10.006 ER - TY - JOUR T1 - Prologue: Development of English Literacy in Spanish-Speaking Children: Transforming Research into Practice AN - 85663317; 200801575 AB - Purpose: The purpose of the present article is to provide the background for the clinical forum contained in this issue of Language, Speech, and Hearing Services in Schools, which showcases prereading and reading development research that was conducted with Spanish-speaking children who were English language learners. Method: We focus on the articles presented in this clinical forum and provide the background for the research. Implications: There is a need for further educational research to ensure that practitioners achieve literacy for all children. Adapted from the source document JF - Language, Speech, and Hearing Services in Schools AU - Garcia, Gil Narro AU - McCardle, Peggy AU - Nixon, Stephanie M AD - c/o McCardle-National Institute of Child Health and Human Development, 6100 Executive Boulevard, Suite 4B05, Rockville, MD 20852-7510 PM43Q@nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 213 EP - 215 VL - 38 IS - 3 SN - 0161-1461, 0161-1461 KW - English as a Second Language Learning (22130) KW - Literacy (48550) KW - Bilingualism (08850) KW - Reading Acquisition (70650) KW - Reading Readiness (71350) KW - Cultural Factors (16500) KW - Spanish (81800) KW - Children (11850) KW - Language Proficiency (43570) KW - article KW - 4122: applied linguistics; bilingualism, bilingual education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85663317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Language%2C+Speech%2C+and+Hearing+Services+in+Schools&rft.atitle=Prologue%3A+Development+of+English+Literacy+in+Spanish-Speaking+Children%3A+Transforming+Research+into+Practice&rft.au=Garcia%2C+Gil+Narro%3BMcCardle%2C+Peggy%3BNixon%2C+Stephanie+M&rft.aulast=Garcia&rft.aufirst=Gil&rft.date=2007-07-01&rft.volume=38&rft.issue=3&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Language%2C+Speech%2C+and+Hearing+Services+in+Schools&rft.issn=01611461&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2008-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - LGSHA4 N1 - SubjectsTermNotLitGenreText - Literacy (48550); Bilingualism (08850); English as a Second Language Learning (22130); Spanish (81800); Cultural Factors (16500); Language Proficiency (43570); Reading Readiness (71350); Reading Acquisition (70650); Children (11850) ER - TY - JOUR T1 - Epilogue: Implications of Research on English Language Learners for Classroom and Clinical Practice AN - 85603302; 200801591 AB - Purpose: The purpose of the present article is to provide the closing context for this clinical forum that showcases prereading and reading development research with Spanish-speaking English language learning children. Method: Background information, including legislation, judicial review, and past research, are used to interpret the results of the studies in the clinical forum. Implications: Suggestions for practitioners and future research are presented based on the clinical forum and background information. Adapted from the source document JF - Language, Speech, and Hearing Services in Schools AU - Nixon, Stephanie M AU - McCardle, Peggy AU - Leos, Kathleen AD - c/o McCardle-National Institute of Child Health and Human Development, 6100 Executive Boulevard, Suite 4B05, Rockville, MD 20852-7510 PM43Q@nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 272 EP - 277 VL - 38 IS - 3 SN - 0161-1461, 0161-1461 KW - English as a Second Language Learning (22130) KW - Educational Policy (20940) KW - Reading Acquisition (70650) KW - Reading Readiness (71350) KW - Spanish (81800) KW - Bilingual Education (08750) KW - Early Literacy (20400) KW - article KW - 4122: applied linguistics; bilingualism, bilingual education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85603302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Language%2C+Speech%2C+and+Hearing+Services+in+Schools&rft.atitle=Epilogue%3A+Implications+of+Research+on+English+Language+Learners+for+Classroom+and+Clinical+Practice&rft.au=Nixon%2C+Stephanie+M%3BMcCardle%2C+Peggy%3BLeos%2C+Kathleen&rft.aulast=Nixon&rft.aufirst=Stephanie&rft.date=2007-07-01&rft.volume=38&rft.issue=3&rft.spage=272&rft.isbn=&rft.btitle=&rft.title=Language%2C+Speech%2C+and+Hearing+Services+in+Schools&rft.issn=01611461&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2008-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - LGSHA4 N1 - SubjectsTermNotLitGenreText - Early Literacy (20400); Reading Readiness (71350); Reading Acquisition (70650); Educational Policy (20940); Bilingual Education (08750); English as a Second Language Learning (22130); Spanish (81800) ER - TY - JOUR T1 - Effect of prefrontal cortex damage on resolving lexical ambiguity in text. AN - 85399037; pmid-17092552 AB - The function of suppression of context-inappropriate meanings during lexical ambiguity resolution was examined in 25 adults with prefrontal cortex damage (PFCD) localized to the left (N=8), right (N=6), or bilaterally (N=11); and 21 matched Controls. Results revealed unexpected inverse patterns of suppression between PFCD and Control groups, with measures suggesting decreased interference across time in the PFCD group and increased interference in the Control group. The PFCD group, however, had significantly lower accuracy rates for the context-inappropriate condition. Results suggest a loss of the control aspects of inhibitory processes in lexical ambiguity resolution following PFCD. An aging effect on suppression function is also suggested. JF - Brain and language AU - Frattali, Carol AU - Hanna, Rebecca AU - McGinty, Anita Shukla AU - Gerber, Lynn AU - Wesley, Robert AU - Grafman, Jordan AU - Coelho, Carl AD - Rehabilitation Medicine Department, W.G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA. Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 99 EP - 113 VL - 102 IS - 1 SN - 0093-934X, 0093-934X KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - *Brain Injuries: pathology KW - *Brain Injuries: physiopathology KW - Female KW - Functional Laterality: physiology KW - Humans KW - Magnetic Resonance Imaging KW - Male KW - Middle Aged KW - Neuropsychological Tests KW - *Prefrontal Cortex: pathology KW - *Prefrontal Cortex: physiopathology KW - Reaction Time KW - Reading KW - Tomography, X-Ray Computed KW - *Vocabulary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85399037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+and+language&rft.atitle=Effect+of+prefrontal+cortex+damage+on+resolving+lexical+ambiguity+in+text.&rft.au=Frattali%2C+Carol%3BHanna%2C+Rebecca%3BMcGinty%2C+Anita+Shukla%3BGerber%2C+Lynn%3BWesley%2C+Robert%3BGrafman%2C+Jordan%3BCoelho%2C+Carl&rft.aulast=Frattali&rft.aufirst=Carol&rft.date=2007-07-01&rft.volume=102&rft.issue=1&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Brain+and+language&rft.issn=0093934X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Real-time image-guided direct convective perfusion of intrinsic brainstem lesions. Technical note. AN - 70762117; 17639894 AB - Recent preclinical studies have demonstrated that convection-enhanced delivery (CED) can be used to perfuse the brain and brainstem with therapeutic agents while simultaneously tracking their distribution using coinfusion of a surrogate magnetic resonance (MR) imaging tracer. The authors describe a technique for the successful clinical application of this drug delivery and monitoring paradigm to the brainstem. Two patients with progressive intrinsic brainstem lesions (one with Type 2 Gaucher disease and one with a diffuse pontine glioma) were treated with CED of putative therapeutic agents mixed with Gd-diethylenetriamene pentaacetic acid (DTPA). Both patients underwent frameless stereotactic placement of MR imaging-compatible outer guide-inner infusion cannulae. Using intraoperative MR imaging, accurate cannula placement was confirmed and real-time imaging during infusion clearly demonstrated progressive filling of the targeted region with the drug and Gd-DTPA infusate. Neither patient had clinical or imaging evidence of short- or long-term infusate-related toxicity. Using this technique, CED can be used to safely perfuse targeted regions of diseased brainstem with therapeutic agents. Coinfused imaging surrogate tracers can be used to monitor and control the distribution of therapeutic agents in vivo. Patients with a variety of intrinsic brainstem and other central nervous system disorders may benefit from a similar treatment paradigm. JF - Journal of neurosurgery AU - Lonser, Russell R AU - Warren, Katherine E AU - Butman, John A AU - Quezado, Zenaide AU - Robison, R Aaron AU - Walbridge, Stuart AU - Schiffman, Raphael AU - Merrill, Marsha AU - Walker, Marion L AU - Park, Deric M AU - Croteau, David AU - Brady, Roscoe O AU - Oldfield, Edward H AD - Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1414, USA. lonserr@ninds.nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 190 EP - 197 VL - 107 IS - 1 SN - 0022-3085, 0022-3085 KW - Contrast Media KW - 0 KW - Gadolinium DTPA KW - K2I13DR72L KW - Abridged Index Medicus KW - Index Medicus KW - Neurosurgical Procedures KW - Magnetic Resonance Imaging KW - Facial Paralysis -- complications KW - Intraoperative Care KW - Humans KW - Cerebrovascular Circulation -- physiology KW - Infant, Newborn KW - Facial Paralysis -- physiopathology KW - Male KW - Catheters, Indwelling KW - Perfusion -- methods KW - Gaucher Disease -- pathology KW - Surgery, Computer-Assisted -- instrumentation KW - Glioma -- blood supply KW - Glioma -- pathology KW - Brain Stem -- blood supply KW - Cerebellar Neoplasms -- pathology KW - Pons -- blood supply KW - Gaucher Disease -- complications KW - Pons -- pathology KW - Brain Stem -- pathology KW - Cerebellar Neoplasms -- surgery KW - Brain Stem -- surgery KW - Pons -- surgery KW - Gaucher Disease -- surgery KW - Glioma -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70762117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurosurgery&rft.atitle=Real-time+image-guided+direct+convective+perfusion+of+intrinsic+brainstem+lesions.+Technical+note.&rft.au=Lonser%2C+Russell+R%3BWarren%2C+Katherine+E%3BButman%2C+John+A%3BQuezado%2C+Zenaide%3BRobison%2C+R+Aaron%3BWalbridge%2C+Stuart%3BSchiffman%2C+Raphael%3BMerrill%2C+Marsha%3BWalker%2C+Marion+L%3BPark%2C+Deric+M%3BCroteau%2C+David%3BBrady%2C+Roscoe+O%3BOldfield%2C+Edward+H&rft.aulast=Lonser&rft.aufirst=Russell&rft.date=2007-07-01&rft.volume=107&rft.issue=1&rft.spage=190&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurosurgery&rft.issn=00223085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-10 N1 - Date created - 2007-07-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.) 3: effect on human lens and retinal pigment epithelial cells. AN - 70759199; 17645667 AB - The dried root or rhizome of Goldenseal (Hydrastis canadensis L.) contains several alkaloids including berberine, hydrastine, palmatine and lesser amounts of canadine and hydrastinine. Preparations derived from Goldenseal have been used to treat skin and eye ailments. Berberine, the major alkaloid in Goldenseal root powder, has been used in eye drops to treat trachoma, a disease characterized by keratoconjunctivitis. Berberine and palmatine are also present in extracts from Berberis amurensis Ruprecht (Berberidaceae) which are used to treat ocular disorders. We have previously shown that Goldenseal alkaloids are phototoxic to keratinocytes (Chem Res Toxicol. 14, 1529, 2001; ibid 19, 739, 2006) and now report their effect on human lens and retinal pigment epithelial cells. Human lens epithelial cells (HLE-B3) were severely damaged when incubated with berberine (25 microM) and exposed to UVA (5 J cm(-2)). Under the same conditions, palmatine was less phototoxic and hydrastine, canadine and hydrastinine were inactive. Moderate protection against berberine phototoxicity was afforded by the antioxidants ascorbate (2 mM) and N-acetylcysteine (5 mM). When exposed to UVA (5 J cm(-2)) both berberine (10 microM) and palmatine (10 microM) caused mild DNA damage as determined by the alkaline comet assay which measures single strand breaks. Berberine and palmatine are the only Goldenseal alkaloids with appreciable absorption above 400 nm. Because light at wavelengths below 400 nm is cut off by the anterior portion of the adult human eye only berberine and palmatine were tested for phototoxicity to human retinal pigment epithelial (hRPE) cells. Although berberine did damage hRPE cells when irradiated with visible light (lambda > 400 nm) approximately 10 times higher concentrations were required to produce the same amount of damage as seen in lens cells. Palmatine was not phototoxic to hRPE cells. Neither berberine nor palmatine photodamaged DNA in hRPE. Infusions of Goldenseal are estimated to contain approximately 1 mM berberine, while in tinctures the alkaloid concentration may be more than 10 times higher. Our findings show that eyewashes and lotions derived from Goldenseal or containing berberine must be used with caution when the eyes are exposed to bright sunlight but that oral preparations are not likely to cause ocular phototoxicity. JF - Photochemistry and photobiology AU - Chignell, Colin F AU - Sik, Robert H AU - Watson, Mary A AU - Wielgus, Albert R AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, NC, USA. chignell@niehs.nih.gov PY - 2007 SP - 938 EP - 943 VL - 83 IS - 4 SN - 0031-8655, 0031-8655 KW - Alkaloids KW - 0 KW - Index Medicus KW - Cells, Cultured KW - Humans KW - Photochemistry KW - Lens, Crystalline -- pathology KW - Cell Survival -- drug effects KW - Pigment Epithelium of Eye -- drug effects KW - Lens, Crystalline -- drug effects KW - Alkaloids -- toxicity KW - Pigment Epithelium of Eye -- radiation effects KW - Lens, Crystalline -- radiation effects KW - Cell Survival -- radiation effects KW - Pigment Epithelium of Eye -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70759199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+photobiology&rft.atitle=Photochemistry+and+photocytotoxicity+of+alkaloids+from+Goldenseal+%28Hydrastis+canadensis+L.%29+3%3A+effect+on+human+lens+and+retinal+pigment+epithelial+cells.&rft.au=Chignell%2C+Colin+F%3BSik%2C+Robert+H%3BWatson%2C+Mary+A%3BWielgus%2C+Albert+R&rft.aulast=Chignell&rft.aufirst=Colin&rft.date=2007-07-01&rft.volume=83&rft.issue=4&rft.spage=938&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+photobiology&rft.issn=00318655&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-13 N1 - Date created - 2007-07-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Prog Retin Eye Res. 2003 Sep;22(5):657-82 [12892645] J Agric Food Chem. 2003 Dec 3;51(25):7352-8 [14640583] Am J Ophthalmol. 2004 Jan;137(1):62-9 [14700645] Indian J Med Res. 1982 Dec;76 Suppl:83-8 [7185757] Arch Biochem Biophys. 1985 Jun;239(2):491-6 [2988452] Exp Cell Res. 1988 Mar;175(1):184-91 [3345800] J Agric Food Chem. 2002 Nov 20;50(24):7013-6 [12428952] Chem Res Toxicol. 2001 Nov;14(11):1529-34 [11712911] Ophthalmic Res. 2007;39(1):32-9 [17164575] Altern Med Rev. 2000 Apr;5(2):175-7 [10767672] Chem Res Toxicol. 2006 Jun;19(6):739-44 [16780351] Invest Ophthalmol Vis Sci. 1993 Jun;34(7):2210-9 [8505203] J Biol Chem. 1993 Jun 25;268(18):13221-7 [8390459] Rev Int Trach Pathol Ocul Trop Subtrop Sante Publique. 1992;69:147-65 [1344968] Invest Ophthalmol Vis Sci. 1994 Jun;35(7):3094-102 [8206728] FASEB J. 1995 Sep;9(12):1173-82 [7672510] Invest Ophthalmol Vis Sci. 1998 Mar;39(3):471-5 [9501855] J Pharm Sci. 1998 Dec;87(12):1479-88 [10189253] Spectrochim Acta A Mol Biomol Spectrosc. 1999 Aug;55A(9):1903-7 [10507886] Exp Eye Res. 2004 Dec;79(6):753-9 [15642312] J Sep Sci. 2005 Jan;28(1):92-7 [15688637] Invest Ophthalmol Vis Sci. 2005 Mar;46(3):1047-53 [15728564] Life Sci. 2005 Oct 28;77(24):3058-67 [15996686] J Pharm Biomed Anal. 2006 Mar 18;40(5):1218-24 [16293389] Am J Ophthalmol. 2002 Dec;134(6):879-83 [12470757] Int J Toxicol. 2002 Nov-Dec;21(6):465-72 [12537643] Int J Toxicol. 2002 Nov-Dec;21(6):491-500 [12537645] Int J Toxicol. 2002 Nov-Dec;21(6):501-9 [12537646] J AOAC Int. 2003 May-Jun;86(3):476-83 [12852562] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Addressing health disparities and environmental justice: the National Library of Medicine's Environmental Health Information Outreach Program. AN - 70732328; 17641769 AB - Disparities in health between minority and majority populations have become a topic of high interest in the health care and information communities. This paper describes the National Library of Medicine's (NLM's) oldest outreach program to a minority population, a project that has been going on for over fifteen years. The overview is based on internal documentation and reports, interviews, personal communications, and project reports. This is a historical overview of the Environmental Health Information Outreach Program, from its beginnings in 1991 as the Toxicology Information Outreach Project. The initial collaboration began with nine historically black colleges and universities (HBCUs) that had graduate programs in biomedicine. The current program includes representation from HBCUs, institutions serving Hispanic students, and tribal colleges. In addition to working with these institutions to promote the use of and access to electronic health information and related technology, this program brings attention to scientific research related to health issues that disproportionately affect minorities. The program expanded due to its perceived success by the initial participants and NLM's management. Not only have faculty, staff, and students at the participating institutions received training in using NLM's toxicology, environmental health, and other electronic resources, but the participants ascribe other successes to their collaboration with NLM. JF - Journal of the Medical Library Association : JMLA AU - Dutcher, Gale A AU - Spann, Melvin AU - Gaines, Cynthia AD - Office of Outreach and Special Populations, Division of Specialized Information Services, National Library of Medicine, Bethesda, MD 20892, USA. dutcherg@mail.nlm.nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 330 EP - 336 VL - 95 IS - 3 KW - Index Medicus KW - United States KW - Cooperative Behavior KW - National Library of Medicine (U.S.) KW - Humans KW - Universities -- organization & administration KW - African Americans KW - Program Evaluation KW - Pilot Projects KW - Organizational Case Studies KW - Environmental Health -- education KW - Health Services Accessibility -- organization & administration KW - Community-Institutional Relations KW - Program Development -- methods KW - Health Education -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70732328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%3A+JMLA&rft.atitle=Addressing+health+disparities+and+environmental+justice%3A+the+National+Library+of+Medicine%27s+Environmental+Health+Information+Outreach+Program.&rft.au=Dutcher%2C+Gale+A%3BSpann%2C+Melvin%3BGaines%2C+Cynthia&rft.aulast=Dutcher&rft.aufirst=Gale&rft.date=2007-07-01&rft.volume=95&rft.issue=3&rft.spage=330&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%3A+JMLA&rft.issn=1558-9439&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-07 N1 - Date created - 2007-07-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Bull Med Libr Assoc. 1996 Apr;84(2 Suppl):1-60 [8826638] Clin Toxicol. 1972;5(2):283-94 [5068319] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lack of evidence for contact sensitization by Pfiesteria extract. AN - 70726704; 17637917 AB - Members of the estuarine dinoflagellate genus Pfiesteria are reported to have been responsible for massive fish kills in the southeastern United States. Some reports suggest that exposure to waters having Pfiesteria blooms or occupation-related exposure might result in Pfiesteria-induced dermal irritation and inflammation. Although the toxin has not been isolated and purified, the original data suggested both hydrophilic and hydrophobic toxic components. Some investigators propose that dermonecrotic properties are associated with a hydrophobic fraction. A bioactive C18-bound putative toxin (CPE) extracted from Pfiesteria-laden aquarium water during active fish-killing conditions was examined in the present study to evaluate its potential to produce inflammation and dermal sensitization and to determine whether the inflammation and dermatitis reported in early human exposure studies were allergic or irritant in nature. This fraction was cytotoxic to mouse Neuro-2A cells and primary human epidermal keratinocytes (NHEK) at a concentration of 1 mg/mL. Balb/C mice exposed to 50-200% CPE by skin painting exhibited a 6-10% increase in ear swelling relative to vehicle-treated mice in a primary irritancy assay. There was no increase in lymph node cell proliferation as measured using the local lymph node assay. Exposure to CPE in culture up-regulated interleukin-8 in NHEK, whereas granulocyte macrophage-colony-stimulating factor and tumor necrosis factor alpha were only minimally altered. This study suggests that CPE is cytotoxic to keratinocytes in culture at high concentrations and that it induces mild, localized irritation but not dermal sensitization. JF - Environmental health perspectives AU - Patterson, Rachel M AU - Noga, Edward AU - Germolec, Dori AD - Toxicology Operations Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 1023 EP - 1028 VL - 115 IS - 7 SN - 0091-6765, 0091-6765 KW - Index Medicus KW - Animals KW - Mice KW - Mice, Inbred BALB C KW - Female KW - Cell Line KW - Pfiesteria piscicida -- immunology KW - Dermatitis, Contact UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70726704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Lack+of+evidence+for+contact+sensitization+by+Pfiesteria+extract.&rft.au=Patterson%2C+Rachel+M%3BNoga%2C+Edward%3BGermolec%2C+Dori&rft.aulast=Patterson&rft.aufirst=Rachel&rft.date=2007-07-01&rft.volume=115&rft.issue=7&rft.spage=1023&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-14 N1 - Date created - 2007-07-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicology. 2000 Jan 17;142(3):203-11 [10667891] Environ Health Perspect. 2006 Jul;114(7):1038-43 [16835056] J Toxicol Environ Health A. 2001 Aug 24;63(8):553-64 [11549115] Environ Health Perspect. 2001 Oct;109 Suppl 5:731-7 [11677182] Environ Health Perspect. 2001 Oct;109 Suppl 5:739-43 [11677183] Environ Health Perspect. 2001 Oct;109 Suppl 5:745-56 [11677184] Environ Health Perspect. 2001 Oct;109 Suppl 5:781-6 [11677189] Environ Health Perspect. 2001 Oct;109 Suppl 5:639-59 [11687383] Regul Toxicol Pharmacol. 2001 Dec;34(3):258-73 [11754530] Neurotoxicol Teratol. 2001 Nov-Dec;23(6):609-16 [11792529] Clin Exp Dermatol. 2002 Mar;27(2):138-46 [11952708] South Med J. 2002 Jul;95(7):720-6 [12144078] Food Chem Toxicol. 2002 Nov;40(11):1719-25 [12176099] Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):10970-5 [12163648] Nature. 2002 Aug 29;418(6901):967-70 [12198545] Environ Health Perspect. 2002 Oct;110 Suppl 5:761-6 [12426128] Neurotoxicol Teratol. 2003 Jul-Aug;25(4):419-26 [12798959] Toxicol In Vitro. 2004 Jun;18(3):231-43 [15046769] Nature. 1992 Jul 30;358(6385):407-10 [1641022] J Toxicol Environ Health. 1995 Dec;46(4):501-22 [8523474] Md Med J. 1997 Nov-Dec;46(10):521-3 [9392940] Environ Health Perspect. 1997 Dec;105(12):1320-5 [9405328] Md Med J. 1998 Feb-Mar;47(2):64-6 [9524412] Md Med J. 1998 May;47(3):124-6 [9601197] Md Med J. 1998 May;47(3):137-43 [9601201] Lancet. 1998 Aug 15;352(9127):532-9 [9716058] Sci Am. 1999 Aug;281(2):42-9 [10443037] Drug Chem Toxicol. 1999 Aug;22(3):491-506 [10445160] Appl Environ Microbiol. 2005 Jan;71(1):519-29 [15640229] Neurotoxicol Teratol. 2005 Sep-Oct;27(5):701-10 [16198085] J Immunol. 2000 Mar 15;164(6):3392-401 [10706735] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A study of the impact of agricultural pesticide use on the prevalence of birth defects in northeast Italy. AN - 70725485; 17561371 AB - Pesticides are probably the most frequently deliberately released toxic chemicals into the environment. However, although the results of experimental studies indicate developmental toxicity hazards for several groups of chemicals used, the studies in humans are contradictory. There are specific regulations in the European Union (EU) regarding the use of pesticides and there is also considerable awareness about possible related health problems. In order to investigate whether, in the current EU situation, the use of certain pesticides could be associated with adverse health effects in the outcome of pregnancies, we have performed a 6-year study in an agricultural area in the Veneto Region of, northeastern Italy, where we have been able to define the exact quantity and type of pesticides as well as the exposed population, in order to quantify the risk of congenital malformations related to the use of pesticides. Data on congenital malformations were obtained from the northeast Italy Congenital malformation Registry, using several sources of ascertainment, while pesticide use were obtained through interviews with users and sellers. The municipalities of three contiguous provinces were divided into those with a high, low or intermediate use of pesticides. In the study period there was a total of 146,239 consecutive pregnancies terminating in birth or induced abortion because of congenital malformation. No significant differences in the prevalence of congenital malformations were observed between the three different areas (high, low, intermediate risk). Our study confirms that in countries such as Italy, where there is close control of the use of pesticides, there is no epidemiological evidence that pesticides have any effect on the prevalence of congenital malformations. JF - Reproductive toxicology (Elmsford, N.Y.) AU - Clementi, Maurizio AU - Causin, Roberto AU - Marzocchi, Cinzia AU - Mantovani, Alberto AU - Tenconi, Romano AD - NEI Registry, Genetica Clinica Epidemiologica, Dipartimento Pediatria, Via Giustiniani 3, 35128 Padova, Italy. maurizio.clementi@unipd.it Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 1 EP - 8 VL - 24 IS - 1 SN - 0890-6238, 0890-6238 KW - Agrochemicals KW - 0 KW - Pesticides KW - Index Medicus KW - Registries -- statistics & numerical data KW - Humans KW - Infant, Newborn KW - Congenital Abnormalities -- epidemiology KW - Italy -- epidemiology KW - Sex Ratio KW - Research Design KW - Male KW - Female KW - Risk Assessment KW - Prevalence KW - Pregnancy KW - Fetus -- drug effects KW - Maternal Exposure -- statistics & numerical data KW - Pesticides -- adverse effects KW - Prenatal Exposure Delayed Effects KW - Agrochemicals -- adverse effects KW - Abortion, Induced -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70725485?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.atitle=A+study+of+the+impact+of+agricultural+pesticide+use+on+the+prevalence+of+birth+defects+in+northeast+Italy.&rft.au=Clementi%2C+Maurizio%3BCausin%2C+Roberto%3BMarzocchi%2C+Cinzia%3BMantovani%2C+Alberto%3BTenconi%2C+Romano&rft.aulast=Clementi&rft.aufirst=Maurizio&rft.date=2007-07-01&rft.volume=24&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.issn=08906238&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-03 N1 - Date created - 2007-07-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Blood metallothionein transcript as a biomarker for metal sensitivity: low blood metallothionein transcripts in arsenicosis patients from Guizhou, China. AN - 70725176; 17637929 AB - Because metallothionein (MT) is a metal-binding protein that protects against metal intoxication, it could be a biomarker for individual sensitivity to metal toxicity. We assessed the use of bloodborne MT transcript as a reflection of tissue MT levels and examined the potential role of MT in arsenic toxicity in an environmentally exposed human population. Rodents were treated with zinc or nonmetallic MT inducers for 4 days, and the blood and tissues were collected for MT transcript analysis by real-time reverse transcriptase-polymerase chain reaction and MT protein determination by the cadmium-hemoglobin assay. Blood and buccal cell samples were collected from arsenicosis patients and healthy subjects residing in Guizhou, China, and total RNA was isolated for MT transcript analysis. There was a positive correlation between blood MT-1 and MT-2 transcripts and corresponding hepatic or renal MT transcript levels in rats and mice. Furthermore, there was a positive correlation between blood MT-1 and MT-2 transcript and tissue MT protein levels in these animals. A positive correlation also occurred between human blood MT and buccal cell MT transcript levels. MT-1A and MT-2A were the major isoform transcripts in human blood and buccal cells, and significantly lower MT levels were seen in arsenicosis patients compared with healthy subjects. Blood MT transcript appears to be a useful biomarker of tissue MT levels. Arsenicosis patients in Guizhou show significantly lower MT transcript levels in blood, which may have predisposed this population to arsenic intoxication. JF - Environmental health perspectives AU - Liu, Jie AU - Cheng, Min-Liang AU - Yang, Qin AU - Shan, Ke-Ren AU - Shen, Jun AU - Zhou, Yushu AU - Zhang, Xinjiang AU - Dill, Anna L AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 1101 EP - 1106 VL - 115 IS - 7 SN - 0091-6765, 0091-6765 KW - Biomarkers KW - 0 KW - DNA Primers KW - RNA, Messenger KW - Metallothionein KW - 9038-94-2 KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Rats KW - Polymerase Chain Reaction KW - Animals KW - Rats, Inbred F344 KW - Base Sequence KW - Humans KW - Male KW - Female KW - China KW - Arsenic -- toxicity KW - RNA, Messenger -- blood KW - Metallothionein -- genetics KW - Biomarkers -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70725176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Blood+metallothionein+transcript+as+a+biomarker+for+metal+sensitivity%3A+low+blood+metallothionein+transcripts+in+arsenicosis+patients+from+Guizhou%2C+China.&rft.au=Liu%2C+Jie%3BCheng%2C+Min-Liang%3BYang%2C+Qin%3BShan%2C+Ke-Ren%3BShen%2C+Jun%3BZhou%2C+Yushu%3BZhang%2C+Xinjiang%3BDill%2C+Anna+L%3BWaalkes%2C+Michael+P&rft.aulast=Liu&rft.aufirst=Jie&rft.date=2007-07-01&rft.volume=115&rft.issue=7&rft.spage=1101&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-14 N1 - Date created - 2007-07-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Toxicol Environ Health A. 1999 Nov 12;58(5):313-27 [10598956] Toxicol Appl Pharmacol. 1985 Mar 30;78(1):63-8 [4035673] Toxicol Sci. 2000 Jun;55(2):460-7 [10828279] J Toxicol Environ Health A. 2000 Dec 15;61(7):553-67 [11127411] Toxicol Sci. 2001 Jan;59(1):185-92 [11134558] Br J Nutr. 2000 Nov;84(5):747-56 [11177190] Toxicology. 2001 Jun 21;163(2-3):93-100 [11516518] J Toxicol Environ Health A. 2001 Nov 23;64(6):473-84 [11732698] J Prev Soc Med. 1999 Jun;18(1):35-40 [12179653] Environ Health Perspect. 2002 Feb;110(2):119-22 [11836136] J Biochem. 2002 Aug;132(2):217-21 [12153718] Environ Health Perspect. 2002 Oct;110 Suppl 5:827-30 [12426140] Carcinogenesis. 2003 Jan;24(1):25-9 [12538345] Toxicol Appl Pharmacol. 2003 Jan 1;186(1):7-17 [12583988] Int J Cancer. 2003 May 10;104(6):735-44 [12640681] Mutat Res. 2003 Dec 10;533(1-2):201-9 [14643421] Pathol Oncol Res. 2004;10(2):74-9 [15188022] Toxicol Sci. 2004 Jul;80(1):69-73 [15071173] Int J Oncol. 2004 Aug;25(2):325-33 [15254729] Yale J Biol Med. 2003;76(2):55-62 [15369632] Cell. 1981 Jul;25(1):233-40 [6168387] Toxicology. 1986 Mar;38(3):261-8 [3952754] Experientia Suppl. 1987;52:519-23 [2959543] Int Arch Occup Environ Health. 1988;60(6):413-7 [3410551] Methods Enzymol. 1991;205:613-26 [1779825] Arch Neurol. 1992 Jul;49(7):721-4 [1497498] Chem Biol Interact. 1992 Dec;85(2-3):127-40 [1493605] Fundam Appl Toxicol. 1993 Feb;20(2):184-9 [8449390] Biochemistry. 1994 Jun 14;33(23):7250-9 [8003488] J Pharmacol Exp Ther. 1996 May;277(2):1026-33 [8627513] Cancer Chemother Pharmacol. 1997;40(4):358-62 [9225956] Annu Rev Pharmacol Toxicol. 1999;39:267-94 [10331085] Cancer Res. 2004 Nov 1;64(21):7766-72 [15520181] Toxicol Lett. 2005 Feb 15;155(2):319-27 [15603927] Toxicol Sci. 2005 Feb;83(2):372-9 [15509664] Environ Health Perspect. 2006 Mar;114(3):404-11 [16507464] Int J Cancer. 2006 Jul 1;119(1):28-32 [16432836] Biomed Environ Sci. 2006 Apr;19(2):104-9 [16827180] J Am Chem Soc. 2006 Sep 27;128(38):12473-83 [16984198] Toxicol Lett. 2006 Nov 1;167(1):47-53 [17029826] Hum Genet. 2006 Nov;120(4):553-60 [16927099] Toxicol Appl Pharmacol. 1982 Oct;66(1):134-42 [7157381] Cell Mol Biol (Noisy-le-grand). 2000 Mar;46(2):419-33 [10774930] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acquisition of apoptotic resistance in cadmium-transformed human prostate epithelial cells: Bcl-2 overexpression blocks the activation of JNK signal transduction pathway. AN - 70723453; 17637928 AB - We have recently shown that cadmium can induce malignant transformation of the human prostate epithelial cell line (RWPE-1) and that these cadmium-transformed prostate epithelial (CTPE) cells acquire apoptotic resistance concurrently with malignant phenotype. The present study was designed to define the mechanism of acquired apoptotic resistance in CTPE cells. Various molecular events associated with apoptosis were assessed in control and CTPE cells that were obtained after 8 weeks of continuous cadmium exposure. Compared with control, CTPE cells showed a generalized resistance to apoptosis induced by cadmium, cisplatin, or etoposide. Signal-regulated mitogen-activated protein kinases, extracellular signal-regulated kinases 1 and 2, c-Jun N-terminal kinases (JNK1 and JNK2), and p38 were phosphorylated in a cadmium concentration-dependent fashion in CTPE and control cells. However, phosphorylated JNK1/2 levels and JNK kinase activity were much lower in CTPE cells. The pro-apoptotic gene Bax showed lower transcript and protein levels, whereas the anti-apoptotic gene Bcl-2 showed higher levels in CTPE cells. The ratio of Bcl-2/Bax, a key determinant in apoptotic commitment, increased more than 4-fold in CTPE cells. In Bcl-2-transfected PT-67 cells, phosphorylated JNK1/2 levels were much lower after apoptogenic stimulus, and apoptosis induced by cadmium or etoposide was reduced compared with control. Mutation of tyrosine to serine at the 21st amino acid of the Bcl-2 protein BH4 domain resulted in a loss both of suppression of JNK1/2 phosphorylation and its anti-apoptotic function. CTPE cells become resistant to apoptosis during malignant transformation, and disruption of the JNK pathway and Bcl-2 overexpression play important roles in this resistance. Bcl-2 BH4 domain is required for modulating JNK phosphorylation and anti-apoptotic function. JF - Environmental health perspectives AU - Qu, Wei AU - Ke, Hengning AU - Pi, Jingbo AU - Broderick, Daniel AU - French, John E AU - Webber, Mukta M AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, NC 27709, USA. Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 1094 EP - 1100 VL - 115 IS - 7 SN - 0091-6765, 0091-6765 KW - DNA Primers KW - 0 KW - Proto-Oncogene Proteins c-bcl-2 KW - Cadmium KW - 00BH33GNGH KW - MAP Kinase Kinase 4 KW - EC 2.7.12.2 KW - Index Medicus KW - Epithelial Cells -- metabolism KW - Blotting, Western KW - Base Sequence KW - Epithelial Cells -- drug effects KW - Phosphorylation KW - Humans KW - Cell Line, Transformed KW - Male KW - Mutagenesis KW - Prostate -- drug effects KW - Cadmium -- pharmacology KW - Signal Transduction -- drug effects KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Apoptosis -- drug effects KW - Prostate -- metabolism KW - MAP Kinase Kinase 4 -- metabolism KW - Prostate -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70723453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Acquisition+of+apoptotic+resistance+in+cadmium-transformed+human+prostate+epithelial+cells%3A+Bcl-2+overexpression+blocks+the+activation+of+JNK+signal+transduction+pathway.&rft.au=Qu%2C+Wei%3BKe%2C+Hengning%3BPi%2C+Jingbo%3BBroderick%2C+Daniel%3BFrench%2C+John+E%3BWebber%2C+Mukta+M%3BWaalkes%2C+Michael+P&rft.aulast=Qu&rft.aufirst=Wei&rft.date=2007-07-01&rft.volume=115&rft.issue=7&rft.spage=1094&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-14 N1 - Date created - 2007-07-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: EMBO J. 2003 Oct 15;22(20):5459-70 [14532118] Drug Resist Updat. 2003 Jun;6(3):147-56 [12860462] J Natl Cancer Inst. 2004 Mar 17;96(6):466-74 [15026472] Arch Toxicol. 1988;61(6):450-6 [3056337] Cell. 1989 Apr 7;57(1):79-88 [2649247] Nature. 1990 Nov 22;348(6299):334-6 [2250705] IARC Monogr Eval Carcinog Risks Hum. 1993;58:119-237 [8022055] Science. 1995 Nov 24;270(5240):1326-31 [7481820] Nature. 1996 Mar 7;380(6569):75-9 [8598911] Mol Cell Biol. 1996 Mar;16(3):877-83 [8622689] J Biol Chem. 1996 Sep 6;271(36):21898-905 [8702992] J Biol Chem. 1996 Oct 25;271(43):27018-24 [8900190] J Cell Biol. 1996 Dec;135(5):1377-82 [8947558] J Biol Chem. 1997 Jul 4;272(27):16725-8 [9201973] Carcinogenesis. 1997 Jun;18(6):1215-23 [9214605] Exp Cell Res. 1997 Aug 1;234(2):442-51 [9260915] EMBO J. 1997 Aug 1;16(15):4628-38 [9303307] EMBO J. 1998 Feb 16;17(4):1029-39 [9463381] Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5045-50 [9560225] Genes Dev. 1999 Aug 1;13(15):1899-911 [10444588] Mol Pharmacol. 1999 Oct;56(4):744-51 [10496957] Int J Cancer. 2005 Apr 10;114(3):346-55 [15551354] Mol Cell Biol. 1999 Dec;19(12):8469-78 [10567572] Int J Cancer. 2000 Jan 1;85(1):60-7 [10585584] J Biol Chem. 2000 Jan 7;275(1):322-7 [10617621] Cell. 2000 Jan 7;100(1):57-70 [10647931] Carcinogenesis. 2000 Mar;21(3):485-95 [10688869] Science. 2000 May 5;288(5467):870-4 [10797012] Cancer Res. 2001 Jan 15;61(2):455-8 [11212230] Prostate. 2001 Apr1;47(1):1-13 [11304724] Toxicol Sci. 2001 Oct;63(2):189-95 [11568362] CA Cancer J Clin. 2001 Jan-Feb;51(1):15-36 [11577478] Carcinogenesis. 2002 Jan;23(1):151-9 [11756236] Mol Cell Biol. 2002 Jul;22(13):4929-42 [12052897] Prostate. 2002 Aug 1;52(3):236-44 [12111698] J Toxicol Environ Health A. 2002 Dec 27;65(24):2131-44 [12515591] J Cell Biochem. 2003 Apr 1;88(5):885-98 [12616528] Neuron. 2003 Jun 19;38(6):899-914 [12818176] J Biol Chem. 2003 Jul 11;278(28):25461-7 [12707267] Mutat Res. 2003 Dec 10;533(1-2):107-20 [14643415] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. AN - 70722435; 17602675 AB - Aminoglutethimide (AG) is a first-generation aromatase inhibitor used for estrogen-dependent breast cancer. Unfortunately, its use has also been associated with agranulocytosis. We have investigated the metabolism of AG by myeloperoxidase (MPO) and the formation of an MPO protein free radical. We hypothesized that AG oxidation by MPO/H2O2 would produce an AG cation radical that, in the absence of a biochemical reductant, would lead to the oxidation of MPO. We utilized a novel anti-DMPO antibody to detect DMPO (5,5-dimethyl-1-pyrroline N-oxide) covalently bound to protein, which forms only by the reaction of DMPO with a protein free radical. We found that AG metabolism by MPO/H2O2 induced the formation of DMPO-MPO, which was inhibited by MPO inhibitors and ascorbate. Glutethimide, a congener of AG that lacks the aromatic amine, did not cause DMPO-MPO formation, indicating the necessity of oxidation of the aniline moiety in AG. When analyzed by electron spin resonance spectroscopy, we detected a phenyl radical adduct, derived from AG, which may be involved in the free radical formation on MPO. Furthermore, we also found protein-DMPO adducts in MPO-containing, intact human promyelocytic leukemia cells (HL-60). MPO was affinity-purified from HL-60 cells treated with AG/H2O2 and was found to contain DMPO. These findings were also supported by the detection of protein free radicals with electron spin resonance in the cellular cytosolic lysate. The formation of an MPO protein free radical is believed to be mediated by one of two free radical drug metabolites of AG, one of which was characterized by spin trapping with 2-methyl-2-nitrosopropane. These results are the first demonstration of MPO free-radical detection by the anti-DMPO antibody that results from drug oxidation. We propose that drug-dependent free radical formation on MPO may play a role in the origin of agranulocytosis. JF - Chemical research in toxicology AU - Siraki, Arno G AU - Bonini, Marcelo G AU - Jiang, JinJie AU - Ehrenshaft, Marilyn AU - Mason, Ronald P AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, North Carolina 27709, USA. sirakia@niehs.nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 1038 EP - 1045 VL - 20 IS - 7 SN - 0893-228X, 0893-228X KW - Aniline Compounds KW - 0 KW - Aromatase Inhibitors KW - Cyclic N-Oxides KW - Free Radicals KW - Nitrogen Oxides KW - Nitroso Compounds KW - Aminoglutethimide KW - 0O54ZQ14I9 KW - 4-aminobenzhydrazide KW - 5351-17-7 KW - 5,5-dimethyl-1-pyrroline-1-oxide KW - 7170JZ1QF3 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Hydrogen Peroxide KW - BBX060AN9V KW - Glutethimide KW - C8I4BVN78E KW - Peroxidase KW - EC 1.11.1.7 KW - nitroxyl KW - GFQ4MMS07W KW - Glucose KW - IY9XDZ35W2 KW - tert-nitrosobutane KW - JGX6N17V2U KW - Ascorbic Acid KW - PQ6CK8PD0R KW - Index Medicus KW - Nitrogen Oxides -- metabolism KW - Aromatase Inhibitors -- pharmacology KW - Aromatase Inhibitors -- chemistry KW - Humans KW - Nitroso Compounds -- chemistry KW - Aniline Compounds -- chemistry KW - Enzyme-Linked Immunosorbent Assay KW - Spectrophotometry KW - Ascorbic Acid -- metabolism KW - Cyclic N-Oxides -- chemistry KW - Nitroso Compounds -- metabolism KW - Glutethimide -- metabolism KW - Dose-Response Relationship, Drug KW - HL-60 Cells KW - Glucose -- metabolism KW - Hydrogen Peroxide -- metabolism KW - Glutethimide -- chemistry KW - Adenosine Triphosphate -- chemistry KW - Chromatography, Affinity KW - Blotting, Western KW - Glucose -- chemistry KW - Electron Spin Resonance Spectroscopy KW - Cyclic N-Oxides -- metabolism KW - Adenosine Triphosphate -- metabolism KW - Nitrogen Oxides -- chemistry KW - Ascorbic Acid -- chemistry KW - Aniline Compounds -- metabolism KW - Hydrogen Peroxide -- chemistry KW - Aminoglutethimide -- pharmacology KW - Peroxidase -- metabolism KW - Aminoglutethimide -- chemistry KW - Free Radicals -- chemistry KW - Agranulocytosis -- metabolism KW - Free Radicals -- metabolism KW - Agranulocytosis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70722435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Aminoglutethimide-induced+protein+free+radical+formation+on+myeloperoxidase%3A+a+potential+mechanism+of+agranulocytosis.&rft.au=Siraki%2C+Arno+G%3BBonini%2C+Marcelo+G%3BJiang%2C+JinJie%3BEhrenshaft%2C+Marilyn%3BMason%2C+Ronald+P&rft.aulast=Siraki&rft.aufirst=Arno&rft.date=2007-07-01&rft.volume=20&rft.issue=7&rft.spage=1038&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-09 N1 - Date created - 2007-07-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Pharmacol. 1991 May 15;41(10):1485-92 [1850278] Drug Metab Rev. 1992;24(3):299-366 [1628536] Biochem Pharmacol. 1993 Jun 22;45(12):2389-97 [8101078] Lancet. 1993 Sep 11;342(8872):651-2 [8103148] Biochemistry. 1994 Feb 15;33(6):1447-54 [8312264] J Pharmacol Exp Ther. 1995 Dec;275(3):1476-83 [8531118] Annu Rev Nutr. 1996;16:33-50 [8839918] Toxicology. 1996 Dec 2;114(2):155-62 [8947614] Biochem J. 1997 Jan 15;321 ( Pt 2):503-8 [9020887] J Pharmacol Exp Ther. 1997 Aug;282(2):795-801 [9262343] Am J Hematol. 1998 Mar;57(3):206-11 [9495370] Arch Biochem Biophys. 1999 Aug 15;368(2):413-20 [10441395] J Biol Chem. 1952 Mar;195(1):133-40 [14938361] Free Radic Biol Med. 2005 Jan 15;38(2):201-14 [15607903] Endocr Rev. 2005 May;26(3):331-45 [15814851] J Urol. 2006 Jan;175(1):27-34 [16406864] Arch Biochem Biophys. 2006 Jan 15;445(2):214-24 [16183032] Free Radic Biol Med. 2006 Aug 1;41(3):422-30 [16843823] Cardiovasc Res. 2007 Jan 15;73(2):341-7 [17141749] Free Radic Biol Med. 2007 Feb 15;42(4):530-40 [17275685] Free Radic Biol Med. 2007 Apr 1;42(7):985-92 [17349926] Protein Expr Purif. 2000 Apr;18(3):269-76 [10733879] Chem Biol Interact. 2000 Dec 1;129(1-2):113-39 [11154738] Am J Pathol. 2001 Dec;159(6):2081-8 [11733358] Antioxid Redox Signal. 2002 Feb;4(1):69-83 [11970845] Free Radic Biol Med. 2002 Aug 1;33(3):364-9 [12126758] Toxicology. 2002 Aug 1;177(1):81-90 [12126797] Free Radic Biol Med. 2003 Apr 1;34(7):830-9 [12654471] Free Radic Biol Med. 2004 May 1;36(9):1072-86 [15082061] Free Radic Biol Med. 2004 May 15;36(10):1214-23 [15110386] J Am Chem Soc. 2004 Oct 13;126(40):12865-73 [15469283] J Biol Chem. 1981 May 10;256(9):4211-8 [6260790] Photochem Photobiol. 1983 Jan;37(1):17-26 [6300940] Cancer. 1984 Oct 15;54(8):1731-3 [6478412] Blood. 1985 Feb;65(2):484-91 [2981591] Blood. 1986 Apr;67(4):865-72 [3006833] Blood. 1986 May;67(5):1504-7 [3008892] J Biol Chem. 1987 Aug 5;262(22):10430-3 [3038881] Biochemistry. 1988 Jul 26;27(15):5470-6 [3179265] J Biol Chem. 1989 Jun 5;264(16):9250-7 [2722829] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Long-term effects of ovulation-stimulating drugs on cancer risk. AN - 70715456; 17623533 AB - Although nulliparity has been extensively related to the risk of ovarian, breast and endometrial cancers, with many studies showing the relationship largely attributable to infertility, treatment effects on cancer risk are poorly understood. Two early studies raised substantial concern when ovulation-stimulating drugs were linked with large increases in ovarian cancer, supporting the notion of an important aetiological role of incessant ovulation. Subsequent studies have been mainly reassuring, although some have suggested possible risk increases among nulligravid women, those with extensive follow-up, and those developing borderline tumours. Results regarding effects of fertility drugs on breast cancer risk are conflicting, with some showing no associations and others demonstrating possible risk increases, although for varying subgroups. In contrast, endometrial cancer results are more consistent, with two recent studies showing increased risks related to clomiphene usage. This is of interest given that clomiphene is structurally similar to tamoxifen, a drug extensively linked with this cancer. Given the recent marketing of fertility drugs and the fact that exposed women are only beginning to reach the cancer age range, further follow-up is necessary. This will also be important to fully resolve effects of exposures such as gonadotrophins, used more recently in conjunction with IVF. JF - Reproductive biomedicine online AU - Brinton, Louise AD - Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, 6120 Executive Blvd., Suite 550, Room 5018, Rockville, MD 20852-7234, USA. brinton@nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 38 EP - 44 VL - 15 IS - 1 SN - 1472-6483, 1472-6483 KW - Fertility Agents, Female KW - 0 KW - Index Medicus KW - Risk Factors KW - Humans KW - Female KW - Genital Neoplasms, Female -- epidemiology KW - Breast Neoplasms -- epidemiology KW - Ovulation Induction -- adverse effects KW - Fertility Agents, Female -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70715456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+biomedicine+online&rft.atitle=Long-term+effects+of+ovulation-stimulating+drugs+on+cancer+risk.&rft.au=Brinton%2C+Louise&rft.aulast=Brinton&rft.aufirst=Louise&rft.date=2007-07-01&rft.volume=15&rft.issue=1&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Reproductive+biomedicine+online&rft.issn=14726483&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-15 N1 - Date created - 2007-07-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Induction of a unique gene expression profile in primary human hepatocytes by hepatitis C virus core, NS3 and NS5A proteins. AN - 70714047; 17404395 AB - Hepatocellular carcinoma (HCC) is a fatal disease and hepatitis B and C viruses (HBV and HCV) are considered as major causative factors for the development of HCC. We have conducted gene expression profiling studies to search for potential target genes responsible for HCV-mediated HCC. Adenoviruses encoding core (HCV structural protein), NS3 and NS5A [HCV non-structural (NS) proteins] were generated and infected individually or together in freshly isolated primary human hepatocytes. An adenovirus harboring the oncogenic HBV protein, HBx, was included for comparison. A microarray platform of over 22,000 human oligos was analyzed to seek out significant differentially expressed genes among these viral proteins. We also compared these gene expression profiles with those obtained from HCV-infected liver samples from chronic liver disease (CLD) patients and HCV-related HCC. We found that HCV-related proteins largely induce unique genes when compared with HBx. In particular, interferon-inducible gene 27 (IFI27) was highly expressed in HCV or core-infected hepatocytes and HCV-related CLD or HCC, but was not significantly expressed in HBx-infected hepatocytes or HBV-related CLD or HCC, indicating that IFI27 may play a role in HCV-mediated HCC. In conclusion, our results suggest that HBV and HCV promote HCC development mainly through different mechanisms. JF - Carcinogenesis AU - Budhu, A AU - Chen, Y AU - Kim, J W AU - Forgues, M AU - Valerie, K AU - Harris, C C AU - Wang, X W AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 1552 EP - 1560 VL - 28 IS - 7 SN - 0143-3334, 0143-3334 KW - IFI27 protein, human KW - 0 KW - Membrane Proteins KW - NS-5 protein, hepatitis C virus KW - NS3 protein, hepatitis C virus KW - Trans-Activators KW - Viral Nonstructural Proteins KW - Viral Regulatory and Accessory Proteins KW - hepatitis B virus X protein KW - Index Medicus KW - Hepatitis B virus -- metabolism KW - Viral Regulatory and Accessory Proteins -- physiology KW - Oligonucleotide Array Sequence Analysis KW - Cells, Cultured KW - Membrane Proteins -- metabolism KW - Humans KW - Viral Regulatory and Accessory Proteins -- genetics KW - Hepatocytes -- metabolism KW - Adenoviridae -- genetics KW - Hepacivirus -- metabolism KW - Carcinoma, Hepatocellular -- virology KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - Viral Nonstructural Proteins -- genetics KW - Liver Neoplasms -- virology KW - Viral Nonstructural Proteins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70714047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Induction+of+a+unique+gene+expression+profile+in+primary+human+hepatocytes+by+hepatitis+C+virus+core%2C+NS3+and+NS5A+proteins.&rft.au=Budhu%2C+A%3BChen%2C+Y%3BKim%2C+J+W%3BForgues%2C+M%3BValerie%2C+K%3BHarris%2C+C+C%3BWang%2C+X+W&rft.aulast=Budhu&rft.aufirst=A&rft.date=2007-07-01&rft.volume=28&rft.issue=7&rft.spage=1552&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-04 N1 - Date created - 2007-07-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nicotine, lung and cancer. AN - 70711956; 17630920 AB - The respiratory epithelium expresses the cholinergic system including nicotinic receptors (nAChRs). It was reported that normal human bronchial epithelial cells (BEC), which are the precursor for squamous cell carcinomas, and small airway epithelial cells (SAEC), which are the precursor for adenocarcinomas, have slightly different repertoires of nAChRs. Studies shown that nAChRs expressed on lung carcinoma or mesothelioma form a part of an autocrine-proliferative network facilitating the growth of neoplastic cells; others demonstrated that nicotine can promote the growth of colon, gastric, and lung cancers. Nicotine and structurally related carcinogens like NNK [4-(methylnitrosoamino)- 1-(3-pyridyl)-1-butanone] and NNN (N'-nitrosonornicotine) could induce the proliferation of a variety of small cell lung carcinoma cell lines and endothelial cells and nicotine in non-neuronal tissues -including lung- induces the secretion of growth factors (bFGF, TGF-alpha, VEGF and PDGF), up regulation of the calpain family proteins, COX-2 and VEGFR-2, causing the eventual activation of Raf/MAPK kinase/ERK (Raf/MEK/ERK) pathway contributing to the growth and progression of tumors exposed to nicotine through tobacco smoke or cigarette substitutes. It has been demonstrated that nicotine promotes the growth of solid tumors in vivo, suggesting that might induce the progression of tumors already initiated. While tobacco carcinogens can initiate and promote tumorigenesis, the exposure to nicotine could confer a proliferative advantage to early tumors but there is no evidence that nicotine itself provokes cancer. This is supported by the findings that nicotine can prevent apoptosis induced by various agents - such as chemotherapeutic in NSCLC, conferring a survival advantage as well. JF - Anti-cancer agents in medicinal chemistry AU - Grozio, Alessia AU - Catassi, Alessia AU - Cavalieri, Zita AU - Paleari, Laura AU - Cesario, Alfredo AU - Russo, Patrizia AD - Translational Research B (Lung Cancer), Department of Integrated Medical Oncology (DOMI), National Cancer Institute, Largo Rosanna Benzi 10, Genoa, Italy. alessia.grozio@libero.it Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 461 EP - 466 VL - 7 IS - 4 SN - 1871-5206, 1871-5206 KW - Receptors, Nicotinic KW - 0 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Neoplasm Invasiveness KW - Animals KW - Epithelial Cells -- cytology KW - Bronchi -- cytology KW - Receptors, Nicotinic -- metabolism KW - Humans KW - Neoplasm Metastasis KW - Models, Chemical KW - Cell Line, Tumor KW - Cell Proliferation KW - Models, Biological KW - Cell Survival KW - Nicotine -- adverse effects KW - Lung -- drug effects KW - Lung Neoplasms -- chemically induced KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70711956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anti-cancer+agents+in+medicinal+chemistry&rft.atitle=Nicotine%2C+lung+and+cancer.&rft.au=Grozio%2C+Alessia%3BCatassi%2C+Alessia%3BCavalieri%2C+Zita%3BPaleari%2C+Laura%3BCesario%2C+Alfredo%3BRusso%2C+Patrizia&rft.aulast=Grozio&rft.aufirst=Alessia&rft.date=2007-07-01&rft.volume=7&rft.issue=4&rft.spage=461&rft.isbn=&rft.btitle=&rft.title=Anti-cancer+agents+in+medicinal+chemistry&rft.issn=18715206&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-09 N1 - Date created - 2007-07-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Disruption of the developing female reproductive system by phytoestrogens: genistein as an example. AN - 70710750; 17604387 AB - Studies in our laboratory have shown that exposure to genistein causes deleterious effects on the developing female reproductive system. Mice treated neonatally on days 1-5 by subcutaneous injection of genistein (0.5-50 mg/kg) exhibited altered ovarian differentiation leading to multioocyte follicles (MOFs) at 2 months of age. Ovarian function and estrous cyclicity were also disrupted by neonatal exposure to genistein with increasing severity observed over time. Reduced fertility was observed in mice treated with genistein (0.5, 5, or 25 mg/kg) and infertility was observed at 50 mg/kg. Mammary gland and behavioral endpoints were also affected by neonatal genistein treatment. Further, transgenerational effects were observed; female offspring obtained from breeding genistein treated females (25 mg/kg) to control males had increased MOFs. Thus, neonatal treatment with genistein at environmentally relevant doses caused adverse consequences on female development which is manifested in adulthood. Whether adverse effects occur in human infants exposed to soy-based products such as soy infant formulas is unknown but the neonatal murine model may help address some of the current uncertainties since we have shown that many effects obtained from feeding genistin, the glycosolated form of genistein found in soy formula, are similar to those obtained from injecting genistein. JF - Molecular nutrition & food research AU - Jefferson, Wendy N AU - Padilla-Banks, Elizabeth AU - Newbold, Retha R AD - Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA. jeffers1@niehs.nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 832 EP - 844 VL - 51 IS - 7 SN - 1613-4125, 1613-4125 KW - Phytoestrogens KW - 0 KW - Genistein KW - DH2M523P0H KW - Index Medicus KW - Ovary -- growth & development KW - Animals KW - Mammary Glands, Animal -- drug effects KW - Uterine Neoplasms -- chemically induced KW - Humans KW - Ovary -- drug effects KW - Infant, Newborn KW - Mammary Glands, Animal -- growth & development KW - Estrous Cycle -- drug effects KW - Maternal Behavior -- drug effects KW - Animals, Newborn -- growth & development KW - Diet KW - Ovary -- physiology KW - Female KW - Male KW - Reproduction -- physiology KW - Reproduction -- drug effects KW - Genistein -- pharmacology KW - Genistein -- adverse effects KW - Phytoestrogens -- pharmacology KW - Phytoestrogens -- adverse effects KW - Phytoestrogens -- administration & dosage KW - Genistein -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70710750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+nutrition+%26+food+research&rft.atitle=Disruption+of+the+developing+female+reproductive+system+by+phytoestrogens%3A+genistein+as+an+example.&rft.au=Jefferson%2C+Wendy+N%3BPadilla-Banks%2C+Elizabeth%3BNewbold%2C+Retha+R&rft.aulast=Jefferson&rft.aufirst=Wendy&rft.date=2007-07-01&rft.volume=51&rft.issue=7&rft.spage=832&rft.isbn=&rft.btitle=&rft.title=Molecular+nutrition+%26+food+research&rft.issn=16134125&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-09 N1 - Date created - 2007-07-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Systematic evaluation of genetic variants in the inflammation pathway and risk of lung cancer. AN - 70710687; 17596594 AB - Inflammatory responses to environmental exposures, such as tobacco smoke, may play a role in lung carcinogenesis. To test this hypothesis, we studied genetic polymorphisms in the inflammation pathway in relation to lung cancer risk. We evaluated a panel of 59 single nucleotide polymorphisms (SNP) in 37 inflammation-related genes among non-Hispanic Caucasian lung cancer cases (N=1,553) and controls (N=1,730) from Houston, Texas. Logistic regression was used to assess associations with lung cancer under a dominant genetic model adjusted for sex, age, and smoking. Haplotypes were estimated with the expectation-maximization algorithm. False-positive report probabilities (FPRP) were calculated for significant associations. Interleukin 1 beta (IL1B) C3954T was associated with lung cancer [odds ratio (OR), 1.27; 95% confidence interval (95% CI), 1.10-1.47; FPRP 0.148]. Two IL1A SNPs (C-889T and Ala(114)Ser) were also related to lung cancer (OR, 1.18-1.22), although FPRPs were higher. One IL1A-IL1B haplotype, containing only the IL1B 3954T allele, was associated with elevated lung cancer risk (OR, 1.80; 95% CI, 1.24-2.61). These associations were stronger in heavy smokers, particularly for IL1B C3954T (OR, 1.59; 95% CI, 1.28-1.97; FPRP 0.004). Lung cancer risk was unrelated to polymorphisms in IL1 receptor or antagonist genes. Associations with lung cancer were also seen for SNPs in granulocyte macrophage colony stimulating factor and peroxisome proliferator-activated factor-delta, but FPRPs were high. IL1A and IL1B polymorphisms are associated with increased lung cancer risk, especially among heavy smokers. IL1A and IL1B are critical signals in initiating inflammation. Our results suggest that a dysregulated inflammatory response to tobacco-induced lung damage promotes carcinogenesis. JF - Cancer research AU - Engels, Eric A AU - Wu, Xifeng AU - Gu, Jian AU - Dong, Qiong AU - Liu, Jun AU - Spitz, Margaret R AD - Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20892, USA. engelse@exchange.nih.gov Y1 - 2007/07/01/ PY - 2007 DA - 2007 Jul 01 SP - 6520 EP - 6527 VL - 67 IS - 13 SN - 0008-5472, 0008-5472 KW - Index Medicus KW - Risk KW - Polymorphism, Single Nucleotide KW - Haplotypes KW - Humans KW - Algorithms KW - Aged KW - Middle Aged KW - Male KW - Female KW - Inflammation KW - False Positive Reactions KW - Genetic Variation KW - Polymorphism, Genetic KW - Lung Neoplasms -- immunology KW - Lung Neoplasms -- genetics KW - Genetic Predisposition to Disease KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70710687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Systematic+evaluation+of+genetic+variants+in+the+inflammation+pathway+and+risk+of+lung+cancer.&rft.au=Engels%2C+Eric+A%3BWu%2C+Xifeng%3BGu%2C+Jian%3BDong%2C+Qiong%3BLiu%2C+Jun%3BSpitz%2C+Margaret+R&rft.aulast=Engels&rft.aufirst=Eric&rft.date=2007-07-01&rft.volume=67&rft.issue=13&rft.spage=6520&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-27 N1 - Date created - 2007-07-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mechanism of spontaneous and receptor-controlled electrical activity in pituitary somatotrophs: experiments and theory. AN - 70706790; 17493919 AB - Cultured pituitary somatotrophs release growth hormone in response to spontaneous Ca(2+) entry through voltage-gated calcium channels (VGCCs) that is governed by plateau-bursting electrical activity and is regulated by several neurohormones, including GH-releasing hormone (GHRH) and somatostatin. Here we combine experiments and theory to clarify the mechanisms underlying spontaneous and receptor-controlled electrical activity. Experiments support a role of a Na(+)-conducting and tetrodotoxin-insensitive channel in controlling spontaneous and GHRH-stimulated pacemaking, the latter in a cAMP-dependent manner; an opposing role of spontaneously active inwardly rectifying K(+) (K(ir)) channels and G-protein-regulated K(ir) channels in somatostatin-mediated inhibition of pacemaking; as well as a role of VGCCs in spiking and large conductance (BK-type) Ca(2+)-activated K(+) channels in plateau bursting. The mathematical model is compatible with a wide variety of experimental data involving pharmacology and extracellular ion substitution and supports the importance of constitutively active tetrodotoxin-insensitive Na(+) and K(ir) channels in maintaining spontaneous pacemaking in pituitary somatotrophs. The model also suggests that these channels are involved in the up- and downregulation of electrical activity by GHRH and somatostatin. In the model, the plateau bursting is controlled by two functional populations of BK channels, characterized by distance from the VGCCs. The rapid activation of the proximal BK channels is critical for the establishment of the plateau, whereas slow recruitment of the distal BK channels terminates the plateau. JF - Journal of neurophysiology AU - Tsaneva-Atanasova, Krasimira AU - Sherman, Arthur AU - van Goor, Frederick AU - Stojilkovic, Stanko S AD - Laboratory of Biological Modeling, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 131 EP - 144 VL - 98 IS - 1 SN - 0022-3077, 0022-3077 KW - Potassium Channels, Calcium-Activated KW - 0 KW - Receptors, Cell Surface KW - Tetrodotoxin KW - 4368-28-9 KW - Somatostatin KW - 51110-01-1 KW - Growth Hormone-Releasing Hormone KW - 9034-39-3 KW - Sodium KW - 9NEZ333N27 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Patch-Clamp Techniques -- methods KW - Animals KW - Electric Stimulation -- methods KW - Computer Simulation KW - Biological Clocks -- physiology KW - Somatostatin -- metabolism KW - Calcium -- pharmacology KW - Potassium Channels, Calcium-Activated -- physiology KW - Sodium -- pharmacology KW - Calcium -- metabolism KW - Rats KW - Rats, Sprague-Dawley KW - Cells, Cultured KW - Growth Hormone-Releasing Hormone -- metabolism KW - Tetrodotoxin -- pharmacology KW - Female KW - Somatotrophs -- physiology KW - Pituitary Gland -- physiology KW - Pituitary Gland -- cytology KW - Membrane Potentials -- physiology KW - Somatotrophs -- radiation effects KW - Somatotrophs -- drug effects KW - Receptors, Cell Surface -- physiology KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70706790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurophysiology&rft.atitle=Mechanism+of+spontaneous+and+receptor-controlled+electrical+activity+in+pituitary+somatotrophs%3A+experiments+and+theory.&rft.au=Tsaneva-Atanasova%2C+Krasimira%3BSherman%2C+Arthur%3Bvan+Goor%2C+Frederick%3BStojilkovic%2C+Stanko+S&rft.aulast=Tsaneva-Atanasova&rft.aufirst=Krasimira&rft.date=2007-07-01&rft.volume=98&rft.issue=1&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurophysiology&rft.issn=00223077&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-02 N1 - Date created - 2007-07-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Efficacy of trabectedin (ecteinascidin-743) in advanced pretreated myxoid liposarcomas: a retrospective study. AN - 70706616; 17586092 AB - Previous studies have suggested that trabectedin (ecteinascidin-743) could have antitumour activity in soft-tissue sarcoma. We aimed to study the usefulness of trabectedin in the treatment of patients with myxoid liposarcomas, a subtype of liposarcoma that is associated with specific chromosomal translocations t(12;16)(q13;p11) or t(12;22)(q13;q12) that result in the formation of DDIT3-FUS or DDIT3-EWSR1 fusion proteins. 51 patients with advanced pretreated myxoid liposarcoma who started treatment with trabectedin between April 4, 2001, and Sept 18, 2006 at five institutions in a compassionate-use programme were analysed retrospectively. Centralised radiological and pathological reviews were done for most patients. Trabectedin was given either as a 24-h continuous infusion or as a 3-h infusion, every 21 days, at 1.1-1.5 mg(2). 558 courses of trabectedin were given in total, with a median of ten courses for each patient (range 1-23). The primary endpoints were response rate and progression-free survival, and the secondary endpoint was overall survival. According to Response Evaluation Criteria in Solid Tumors (RECIST), after a median follow-up of 14.0 months (IQR 8.7-20.0), two patients had complete responses (CR) and 24 patients had partial responses (PR); the overall response was 51% (95% CI 36-65). Five patients had early progressive disease. In 17 of the 23 patients who achieved PR or CR as defined by RECIST and who had centralised radiological review, tissue-density changes, consisting of a decrease in tumour density on CT scan or a decrease in contrast enhancement on MRI (or both), preceded tumour shrinkage. Median progression-free survival was 14.0 months (13.1-21.0), and progression-free survival at 6 months was 88% (79-95). Trabectedin was associated with antitumour activity in this series of patients with myxoid liposarcoma. The noted patterns of tumour response were such that tissue density changes occurred before tumour shrinkage in several patients. In some patients, tissue-density changes only were seen. Long-lasting tumour control was noted in responsive patients. The compassionate-use programme is still ongoing. This analysis has resulted in the initiation of two prospective studies to assess the role of trabectedin in the treatment of patients with myxoid liposarcoma in preoperative and metastatic settings. Furthermore, the selective mechanism of action for trabectedin in this translocation-related sarcoma is being studied. JF - The Lancet. Oncology AU - Grosso, Federica AU - Jones, Robin L AU - Demetri, George D AU - Judson, Ian R AU - Blay, Jean-Yves AU - Le Cesne, Axel AU - Sanfilippo, Roberta AU - Casieri, Paola AU - Collini, Paola AU - Dileo, Palma AU - Spreafico, Carlo AU - Stacchiotti, Silvia AU - Tamborini, Elena AU - Tercero, Juan Carlos AU - Jimeno, Josè AU - D'Incalci, Maurizio AU - Gronchi, Alessandro AU - Fletcher, Jonathan A AU - Pilotti, Silvana AU - Casali, Paolo G AD - Cancer Medicine Department, Adult Sarcoma Medical Treatment Unit, IRCCS Foundation-National Cancer Institute, Milan, Italy. federica.grosso@istitutotumori.mi.it Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 595 EP - 602 VL - 8 IS - 7 SN - 1470-2045, 1470-2045 KW - Antineoplastic Agents, Alkylating KW - 0 KW - Dioxoles KW - Oncogene Proteins, Fusion KW - Tetrahydroisoquinolines KW - trabectedin KW - ID0YZQ2TCP KW - Index Medicus KW - Magnetic Resonance Imaging KW - Disease-Free Survival KW - Humans KW - Oncogene Proteins, Fusion -- genetics KW - Adult KW - Tomography, X-Ray Computed KW - Retrospective Studies KW - Oncogene Proteins, Fusion -- metabolism KW - Middle Aged KW - Male KW - Female KW - Tetrahydroisoquinolines -- therapeutic use KW - Liposarcoma, Myxoid -- pathology KW - Antineoplastic Agents, Alkylating -- therapeutic use KW - Liposarcoma, Myxoid -- drug therapy KW - Dioxoles -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70706616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Lancet.+Oncology&rft.atitle=Efficacy+of+trabectedin+%28ecteinascidin-743%29+in+advanced+pretreated+myxoid+liposarcomas%3A+a+retrospective+study.&rft.au=Grosso%2C+Federica%3BJones%2C+Robin+L%3BDemetri%2C+George+D%3BJudson%2C+Ian+R%3BBlay%2C+Jean-Yves%3BLe+Cesne%2C+Axel%3BSanfilippo%2C+Roberta%3BCasieri%2C+Paola%3BCollini%2C+Paola%3BDileo%2C+Palma%3BSpreafico%2C+Carlo%3BStacchiotti%2C+Silvia%3BTamborini%2C+Elena%3BTercero%2C+Juan+Carlos%3BJimeno%2C+Jos%C3%A8%3BD%27Incalci%2C+Maurizio%3BGronchi%2C+Alessandro%3BFletcher%2C+Jonathan+A%3BPilotti%2C+Silvana%3BCasali%2C+Paolo+G&rft.aulast=Grosso&rft.aufirst=Federica&rft.date=2007-07-01&rft.volume=8&rft.issue=7&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=The+Lancet.+Oncology&rft.issn=14702045&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-28 N1 - Date created - 2007-07-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Lancet Oncol. 2007 Jul;8(7):565-7 [17613417] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Preventive effects of polyphenon E on urinary bladder and mammary cancers in rats and correlations with serum and urine levels of tea polyphenols. AN - 70705397; 17620432 AB - Polyphenon E, a standardized mixture of green tea polyphenols, was examined for its chemopreventive efficacy against chemically induced urinary bladder and mammary cancers. In the present study, Polyphenon E was administered after the last dose of 4-hydroxybutyl(butyl)nitrosamine, or roughly 30% of the way into the experiment. Polyphenon E (100 or 250 mg/kg body weight/d) caused a dose-dependent decrease in palpable urinary bladder tumors [low dose, 14 of 34; high dose, 6 of 35; controls, 20 of 34 (P < 0.01)]. In the mammary cancer model, Polyphenon E [333 or 1,000 mg/kg body weight (BW)/d] was administered beginning 5 days after a single dose of methylnitrosourea. In contrast to its significant efficacy in bladder tumor prevention, Polyphenon E had a minimal effect in the prevention of mammary cancers. Levels of polyphenols were determined in the urine and serum of rats. Relatively high levels of various polyphenols (and metabolites) were found in the urine. However, virtually no epigallocatechin-3-gallate was observed in the urine because of low systemic bioavailability; although it represents almost 65% of the polyphenols in Polyphenon E. Levels of polyphenols in serum were 50 x to 1,000 x less than were observed in urine. The bioavailability of these tea polyphenols to different organ sites may contribute to the differing preventive efficacy of Polyphenon E against urinary bladder and mammary cancers. JF - Molecular cancer therapeutics AU - Lubet, Ronald A AU - Yang, Chung S AU - Lee, Mao-Jung AU - Hara, Yukihiko AU - Kapetanovic, Izet M AU - Crowell, James A AU - Steele, Vernon E AU - Juliana, M Margaret AU - Grubbs, Clinton J AD - National Cancer Institute, Executive Plaza North, Suite 2110, 6130 Executive Boulevard, Bethesda, MD 20852, USA. lubetr@mail.nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 2022 EP - 2028 VL - 6 IS - 7 SN - 1535-7163, 1535-7163 KW - Flavonoids KW - 0 KW - Phenols KW - Polyphenols KW - Tea KW - polyphenon E KW - Catechin KW - 8R1V1STN48 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Rats, Inbred F344 KW - Female KW - Flavonoids -- blood KW - Phenols -- blood KW - Catechin -- analogs & derivatives KW - Tea -- chemistry KW - Catechin -- chemistry KW - Mammary Neoplasms, Experimental -- chemically induced KW - Urinary Bladder Neoplasms -- prevention & control KW - Flavonoids -- chemistry KW - Flavonoids -- urine KW - Phenols -- chemistry KW - Mammary Neoplasms, Experimental -- prevention & control KW - Phenols -- urine KW - Catechin -- pharmacology KW - Urinary Bladder Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70705397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Preventive+effects+of+polyphenon+E+on+urinary+bladder+and+mammary+cancers+in+rats+and+correlations+with+serum+and+urine+levels+of+tea+polyphenols.&rft.au=Lubet%2C+Ronald+A%3BYang%2C+Chung+S%3BLee%2C+Mao-Jung%3BHara%2C+Yukihiko%3BKapetanovic%2C+Izet+M%3BCrowell%2C+James+A%3BSteele%2C+Vernon+E%3BJuliana%2C+M+Margaret%3BGrubbs%2C+Clinton+J&rft.aulast=Lubet&rft.aufirst=Ronald&rft.date=2007-07-01&rft.volume=6&rft.issue=7&rft.spage=2022&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-19 N1 - Date created - 2007-07-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Removal of arsenic as arsenite from groundwater/wastewater as stable metal ferrite. AN - 70703223; 17616879 AB - This paper summarizes the results of the study on removal of arsenite ions in liquid medium at an ambient temperature by ferritization and its application in wastewater/groundwater treatment. X-ray Diffractometry (XRD), thermal analysis and dc resistivity measurement have characterized the ferruginous material (Arsenic ferrite) precipitated by both the aeration and ageing procedures. The laboratory scale experiments conducted with synthetic solution of arsenite at different concentration suggest that the arsenite ions can be effectively retrieved > 99%. The recovered arsenic ferrites may find commercial application as semiconductors, catalysts, metal scavengers, etc. JF - Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering AU - Zade, Prashant D AU - Dharmadhikari, Dattatray M AD - National Institute of Miners' Health (NIMH), Nagpur, India. p_zade2000@yahoo.com Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 1073 EP - 1079 VL - 42 IS - 8 SN - 1093-4529, 1093-4529 KW - Arsenites KW - 0 KW - Ferric Compounds KW - Solutions KW - Water Pollutants, Chemical KW - ferrite KW - 1317-54-0 KW - arsenite KW - N5509X556J KW - Index Medicus KW - X-Ray Diffraction KW - Hydrogen-Ion Concentration KW - Temperature KW - Ferric Compounds -- isolation & purification KW - Arsenites -- isolation & purification KW - Water Pollutants, Chemical -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70703223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+science+and+health.+Part+A%2C+Toxic%2Fhazardous+substances+%26+environmental+engineering&rft.atitle=Removal+of+arsenic+as+arsenite+from+groundwater%2Fwastewater+as+stable+metal+ferrite.&rft.au=Zade%2C+Prashant+D%3BDharmadhikari%2C+Dattatray+M&rft.aulast=Zade&rft.aufirst=Prashant&rft.date=2007-07-01&rft.volume=42&rft.issue=8&rft.spage=1073&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+science+and+health.+Part+A%2C+Toxic%2Fhazardous+substances+%26+environmental+engineering&rft.issn=10934529&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-12 N1 - Date created - 2007-07-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genital transmission of HPV in a mouse model is potentiated by nonoxynol-9 and inhibited by carrageenan. AN - 70702645; 17603495 AB - Genital human papillomavirus (HPV) infection is the most common sexually transmitted infection, and virtually all cases of cervical cancer are attributable to infection by a subset of HPVs (reviewed in ref. 1). Despite the high incidence of HPV infection and the recent development of a prophylactic vaccine that confers protection against some HPV types, many features of HPV infection are poorly understood. It remains worthwhile to consider other interventions against genital HPVs, particularly those that target infections not prevented by the current vaccine. However, productive papillomavirus infection is species- and tissue-restricted, and traditional models use animal papillomaviruses that infect the skin or oral mucosa. Here we report the development of a mouse model of cervicovaginal infection with HPV16 that recapitulates the establishment phase of papillomavirus infection. Transduction of a reporter gene by an HPV16 pseudovirus was characterized by histology and quantified by whole-organ, multispectral imaging. Disruption of the integrity of the stratified or columnar genital epithelium was required for infection, which occurred after deposition of the virus on the basement membrane underlying basal keratinocytes. A widely used vaginal spermicide, nonoxynol-9 (N-9), greatly increased susceptibility to infection. In contrast, carrageenan, a polysaccharide present in some vaginal lubricants, prevented infection even in the presence of N-9, suggesting that carrageenan might serve as an effective topical HPV microbicide. JF - Nature medicine AU - Roberts, Jeffrey N AU - Buck, Christopher B AU - Thompson, Cynthia D AU - Kines, Rhonda AU - Bernardo, Marcelino AU - Choyke, Peter L AU - Lowy, Douglas R AU - Schiller, John T AD - Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4263, USA. Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 857 EP - 861 VL - 13 IS - 7 SN - 1078-8956, 1078-8956 KW - Spermatocidal Agents KW - 0 KW - Nonoxynol KW - 26027-38-3 KW - Carrageenan KW - 9000-07-1 KW - Index Medicus KW - Vagina -- drug effects KW - Animals KW - Mucous Membrane -- virology KW - Mucous Membrane -- cytology KW - Vagina -- virology KW - Mice KW - Capsid -- physiology KW - Female KW - Spermatocidal Agents -- pharmacology KW - Carrageenan -- pharmacology KW - Human papillomavirus 16 -- physiology KW - Papillomavirus Infections -- transmission KW - Papillomavirus Infections -- virology KW - Nonoxynol -- pharmacology KW - Papillomavirus Infections -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70702645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+medicine&rft.atitle=Genital+transmission+of+HPV+in+a+mouse+model+is+potentiated+by+nonoxynol-9+and+inhibited+by+carrageenan.&rft.au=Roberts%2C+Jeffrey+N%3BBuck%2C+Christopher+B%3BThompson%2C+Cynthia+D%3BKines%2C+Rhonda%3BBernardo%2C+Marcelino%3BChoyke%2C+Peter+L%3BLowy%2C+Douglas+R%3BSchiller%2C+John+T&rft.aulast=Roberts&rft.aufirst=Jeffrey&rft.date=2007-07-01&rft.volume=13&rft.issue=7&rft.spage=857&rft.isbn=&rft.btitle=&rft.title=Nature+medicine&rft.issn=10788956&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-05 N1 - Date created - 2007-07-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alcoholism is associated with GALR3 but not two other galanin receptor genes. AN - 70697391; 17083333 AB - The neuropeptide galanin is widely expressed in the periphery and the central nervous system and mediates diverse physiological processes and behaviors including alcohol abuse, depression and anxiety. Four genes encoding galanin and its receptors have been identified (GAL, GALR1, GALR2 and GALR3). Recently we found that GAL haplotypes were associated with alcoholism, raising the possibility that genetic variation in GALR1, GALR2 and GALR3 might also alter alcoholism risk. Tag single nucleotide polymorphisms (SNPs) were identified by genotyping SNP panels in controls from five populations. For the association study with alcoholism, six GALR1, four GALR2 and four GALR3 SNPs were genotyped in a large cohort of Finnish alcoholics and non-alcoholics. GALR3 showed a significant association with alcoholism that was driven by one SNP (rs3,091,367). Moreover, the combination of the GALR3 rs3,091,367 risk allele and GAL risk haplotypes led to a modestly increased odds ratio (OR) for alcoholism (2.4) as compared with the effect of either GAL (1.9) or GALR3 alone (1.4). Likewise, the combination of the GALR3 and GAL risk diplotypes led to an increased OR for alcoholism (4.6) as compared with the effect of either GAL (2.0) or GALR3 alone (1.6). There was no effect of GALR1 or GALR2 on alcoholism risk. This evidence suggests that GALR3 mediates the alcoholism-related actions of galanin. JF - Genes, brain, and behavior AU - Belfer, I AU - Hipp, H AU - Bollettino, A AU - McKnight, C AU - Evans, C AU - Virkkunen, M AU - Albaugh, B AU - Max, M B AU - Goldman, D AU - Enoch, M A AD - Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, DHHS, Bethesda, MD 20892, USA. ibelfer@mail.nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 473 EP - 481 VL - 6 IS - 5 SN - 1601-1848, 1601-1848 KW - Receptor, Galanin, Type 1 KW - 0 KW - Receptor, Galanin, Type 2 KW - Receptor, Galanin, Type 3 KW - Index Medicus KW - Reference Values KW - Analysis of Variance KW - Odds Ratio KW - Polymorphism, Single Nucleotide KW - Finland KW - Humans KW - Linkage Disequilibrium KW - Receptor, Galanin, Type 2 -- genetics KW - Haplotypes KW - Risk Factors KW - Adult KW - Case-Control Studies KW - Receptor, Galanin, Type 1 -- genetics KW - Male KW - Genetic Predisposition to Disease -- genetics KW - Receptor, Galanin, Type 3 -- genetics KW - Alcoholism -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70697391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genes%2C+brain%2C+and+behavior&rft.atitle=Alcoholism+is+associated+with+GALR3+but+not+two+other+galanin+receptor+genes.&rft.au=Belfer%2C+I%3BHipp%2C+H%3BBollettino%2C+A%3BMcKnight%2C+C%3BEvans%2C+C%3BVirkkunen%2C+M%3BAlbaugh%2C+B%3BMax%2C+M+B%3BGoldman%2C+D%3BEnoch%2C+M+A&rft.aulast=Belfer&rft.aufirst=I&rft.date=2007-07-01&rft.volume=6&rft.issue=5&rft.spage=473&rft.isbn=&rft.btitle=&rft.title=Genes%2C+brain%2C+and+behavior&rft.issn=16011848&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-19 N1 - Date created - 2007-07-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Disease progression after bone marrow transplantation in a model of multiple sclerosis is associated with chronic microglial and glial progenitor response. AN - 70695809; 17620989 AB - Multiple sclerosis (MS), the most common nontraumatic cause of neurologic disability in young adults in economically developed countries, is characterized by inflammation, gliosis, demyelination, and neuronal degeneration in the CNS. Bone marrow transplantation (BMT) can suppress inflammatory disease in a majority of patients with MS but retards clinical progression only in patients treated in the early stages of the disease. Here, we applied BMT in a mouse model of neuroinflammation, experimental autoimmune encephalomyelitis (EAE), and investigated the kinetics of reconstitution of the immune system in the periphery and in the CNS using bone marrow cells isolated from syngeneic donors constitutively expressing green fluorescent protein. This approach allowed us to dissect the contribution of donor cells to the turnover of resident microglia and to the pathogenesis of observed disease relapses after BMT. BMT effectively blocked or delayed EAE development when mice were treated early in the course of the disease but was without effect in mice with chronic disease. We found that there is minimal overall replacement of host microglia with donor cells in the CNS and that newly transplanted cells do not appear to contribute to disease progression. In contrast, EAE relapses are accompanied by the robust activation of endogenous microglial and macroglial cells, which further involves the maturation of endogenous Olig2 glial progenitor cells into reactive astrocytes through the cytoplasmic translocation of Olig2 and the expression of CD44 on the cellular membrane. The observed maturation of large numbers of reactive astrocytes from glial progenitors and the chronic activation of host microglial cells have relevance for our understanding of the resident glial response to inflammatory injury in the CNS. Our data indicate that reactivation of a local inflammatory process after BMT is sustained predominantly by endogenous microglia/macrophages. JF - Journal of neuropathology and experimental neurology AU - Cassiani-Ingoni, Riccardo AU - Muraro, Paolo A AU - Magnus, Tim AU - Reichert-Scrivner, Susan AU - Schmidt, Jens AU - Huh, Jaebong AU - Quandt, Jacqueline A AU - Bratincsak, Andras AU - Shahar, Tal AU - Eusebi, Fabrizio AU - Sherman, Larry S AU - Mattson, Mark P AU - Martin, Roland AU - Rao, Mahendra S AD - Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. cassianiingoni@gmail.com Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 637 EP - 649 VL - 66 IS - 7 SN - 0022-3069, 0022-3069 KW - Antigens, CD KW - 0 KW - Basic Helix-Loop-Helix Transcription Factors KW - Glial Fibrillary Acidic Protein KW - Glycoproteins KW - Myelin-Oligodendrocyte Glycoprotein KW - Nerve Tissue Proteins KW - Olig2 protein, mouse KW - Peptide Fragments KW - myelin oligodendrocyte glycoprotein (35-55) KW - Index Medicus KW - Animals KW - Encephalomyelitis, Autoimmune, Experimental -- pathology KW - Encephalomyelitis, Autoimmune, Experimental -- chemically induced KW - Disease Progression KW - Glial Fibrillary Acidic Protein -- metabolism KW - Disease Models, Animal KW - Encephalomyelitis, Autoimmune, Experimental -- surgery KW - Mice KW - Cell Proliferation KW - Flow Cytometry -- methods KW - Brain -- pathology KW - Basic Helix-Loop-Helix Transcription Factors -- metabolism KW - Mice, Inbred C57BL KW - Antigens, CD -- metabolism KW - Spinal Cord -- pathology KW - Nerve Tissue Proteins -- metabolism KW - Bone Marrow Transplantation -- methods KW - Microglia -- physiology KW - Stem Cells -- physiology KW - Multiple Sclerosis -- pathology KW - Multiple Sclerosis -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70695809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuropathology+and+experimental+neurology&rft.atitle=Disease+progression+after+bone+marrow+transplantation+in+a+model+of+multiple+sclerosis+is+associated+with+chronic+microglial+and+glial+progenitor+response.&rft.au=Cassiani-Ingoni%2C+Riccardo%3BMuraro%2C+Paolo+A%3BMagnus%2C+Tim%3BReichert-Scrivner%2C+Susan%3BSchmidt%2C+Jens%3BHuh%2C+Jaebong%3BQuandt%2C+Jacqueline+A%3BBratincsak%2C+Andras%3BShahar%2C+Tal%3BEusebi%2C+Fabrizio%3BSherman%2C+Larry+S%3BMattson%2C+Mark+P%3BMartin%2C+Roland%3BRao%2C+Mahendra+S&rft.aulast=Cassiani-Ingoni&rft.aufirst=Riccardo&rft.date=2007-07-01&rft.volume=66&rft.issue=7&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuropathology+and+experimental+neurology&rft.issn=00223069&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-31 N1 - Date created - 2007-07-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - CD14 is an essential mediator of LPS-induced airway disease. AN - 70692881; 17384086 AB - Chronic lipopolysaccharide (LPS) inhalation in rodents recapitulates many classic features of chronic obstructive pulmonary disease seen in humans, including airways hyperresponsiveness, neutrophilic inflammation, cytokine production in the lung, and small airways remodeling. CD14-deficient mice (C57BL/6(CD14-/-)) have an altered response to systemic LPS, and yet the role of CD14 in the response to inhaled LPS has not been defined. We observed that C57BL/6(CD14-/-) mice demonstrate no discernable physiological or inflammatory response to a single LPS inhalation challenge. However, the physiological (airways hyperresponsiveness) and inflammatory (presence of neutrophils and TNF-alpha in whole lung lavage fluid) responsiveness to inhaled LPS in C57BL/6(CD14-/-) mice was restored by instilling soluble CD14 intratracheally. Intratracheal instillation of wild-type macrophages into C57BL/6(CD14-/-) mice restored neutrophilic inflammation only and failed to restore airways hyperresponsiveness or TNF-alpha protein in whole lung lavage. These findings demonstrate that CD14 is critical to LPS-induced airway disease and that macrophage CD14 is sufficient to initiate neutrophil recruitment into the airways but that CD14 may need to interact with other cell types as well for the development of airways hyperresponsiveness and for cytokine production. JF - American journal of physiology. Lung cellular and molecular physiology AU - Brass, David M AU - Hollingsworth, John W AU - McElvania-Tekippe, Erin AU - Garantziotis, Stavros AU - Hossain, Imtaz AU - Schwartz, David A AD - National Institute of Environmental Health Sciences, Rall Bldg., Rm. C224, PO Box 12233 MD C2-15, 111 Alexander Dr., Research Triangle Park, NC 27709, USA. brassd@niehs.nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - L77 EP - L83 VL - 293 IS - 1 SN - 1040-0605, 1040-0605 KW - Antigens, CD14 KW - 0 KW - Lipopolysaccharides KW - Tumor Necrosis Factor-alpha KW - Index Medicus KW - Animals KW - Solubility KW - Neutrophils -- immunology KW - Mice KW - Inflammation KW - Adoptive Transfer KW - Bronchoalveolar Lavage Fluid -- chemistry KW - Mice, Inbred C57BL KW - Enzyme-Linked Immunosorbent Assay KW - Tumor Necrosis Factor-alpha -- metabolism KW - Administration, Inhalation KW - Macrophages, Alveolar -- immunology KW - Bronchial Hyperreactivity -- pathology KW - Male KW - Lipopolysaccharides -- administration & dosage KW - Lipopolysaccharides -- pharmacology KW - Respiratory Tract Diseases -- chemically induced KW - Antigens, CD14 -- metabolism KW - Respiratory Tract Diseases -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70692881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Lung+cellular+and+molecular+physiology&rft.atitle=CD14+is+an+essential+mediator+of+LPS-induced+airway+disease.&rft.au=Brass%2C+David+M%3BHollingsworth%2C+John+W%3BMcElvania-Tekippe%2C+Erin%3BGarantziotis%2C+Stavros%3BHossain%2C+Imtaz%3BSchwartz%2C+David+A&rft.aulast=Brass&rft.aufirst=David&rft.date=2007-07-01&rft.volume=293&rft.issue=1&rft.spage=L77&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Lung+cellular+and+molecular+physiology&rft.issn=10400605&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-29 N1 - Date created - 2007-07-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. AN - 70690663; 17616758 AB - This report is a summary of a symposium on the role of S-adenosylmethionine (SAM), betaine, and folate in the treatment of alcoholic liver disease (ALD), which was organized by the National Institute on Alcohol Abuse and Alcoholism in collaboration with the Office of Dietary Supplements and the National Center for Complementary and Alternative Medicine of the National Institutes of Health (Bethesda, MD) and held on 3 October 2005. SAM supplementation may attenuate ALD by decreasing oxidative stress through the up-regulation of glutathione synthesis, reducing inflammation via the down-regulation of tumor necrosis factor-alpha and the up-regulation of interleukin-10 synthesis, increasing the ratio of SAM to S-adenosylhomocysteine (SAH), and inhibiting the apoptosis of normal hepatocytes and stimulating the apoptosis of liver cancer cells. Folate deficiency may accelerate or promote ALD by increasing hepatic homocysteine and SAH concentrations; decreasing hepatic SAM and glutathione concentrations and the SAM-SAH ratio; increasing cytochrome P4502E1 activation and lipid peroxidation; up-regulating endoplasmic reticulum stress markers, including sterol regulatory element-binding protein-1, and proapoptotic gene caspase-12; and decreasing global DNA methylation. Betaine may attenuate ALD by increasing the synthesis of SAM and, eventually, glutathione, decreasing the hepatic concentrations of homocysteine and SAH, and increasing the SAM-SAH ratio, which can trigger a cascade of events that lead to the activation of phosphatidylethanolamine methyltransferase, increased phosphatidylcholine synthesis, and formation of VLDL for the export of triacylglycerol from the liver to the circulation. Additionally, decreased concentrations of homocysteine can down-regulate endoplasmic reticulum stress, which leads to the attenuation of apoptosis and fatty acid synthesis. JF - The American journal of clinical nutrition AU - Purohit, Vishnudutt AU - Abdelmalek, Manal F AU - Barve, Shirish AU - Benevenga, Norlin J AU - Halsted, Charles H AU - Kaplowitz, Neil AU - Kharbanda, Kusum K AU - Liu, Qi-Ying AU - Lu, Shelly C AU - McClain, Craig J AU - Swanson, Christine AU - Zakhari, Samir AD - Division of Metabolism and Health Effects, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA. vpurohit@mail.nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 14 EP - 24 VL - 86 IS - 1 SN - 0002-9165, 0002-9165 KW - Betaine KW - 3SCV180C9W KW - S-Adenosylmethionine KW - 7LP2MPO46S KW - Folic Acid KW - 935E97BOY8 KW - Methionine KW - AE28F7PNPL KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Humans KW - Disease Models, Animal KW - Liver Diseases, Alcoholic -- metabolism KW - Folic Acid -- metabolism KW - Betaine -- metabolism KW - Methionine -- metabolism KW - S-Adenosylmethionine -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70690663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.atitle=Role+of+S-adenosylmethionine%2C+folate%2C+and+betaine+in+the+treatment+of+alcoholic+liver+disease%3A+summary+of+a+symposium.&rft.au=Purohit%2C+Vishnudutt%3BAbdelmalek%2C+Manal+F%3BBarve%2C+Shirish%3BBenevenga%2C+Norlin+J%3BHalsted%2C+Charles+H%3BKaplowitz%2C+Neil%3BKharbanda%2C+Kusum+K%3BLiu%2C+Qi-Ying%3BLu%2C+Shelly+C%3BMcClain%2C+Craig+J%3BSwanson%2C+Christine%3BZakhari%2C+Samir&rft.aulast=Purohit&rft.aufirst=Vishnudutt&rft.date=2007-07-01&rft.volume=86&rft.issue=1&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+clinical+nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-04 N1 - Date created - 2007-07-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Disulfiram inhibits defluorination of (18)F-FCWAY, reduces bone radioactivity, and enhances visualization of radioligand binding to serotonin 5-HT1A receptors in human brain. AN - 70687087; 17574977 AB - (18)F-trans-4-Fluoro-N-2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-(2-pyridyl)cyclohexanecarboxamide ((18)F-FCWAY) is a PET radioligand for imaging serotonin 5-hydroxytryptamine-1A receptors in brain. (18)F-FCWAY undergoes significant defluorination, with high uptake of radioactivity in the skull and resulting spillover contamination in the underlying neocortex. The cytochrome P450 enzyme CYP2E1 defluorinates many drugs. We previously showed that miconazole, an inhibitor of CYP2E1, blocks defluorination of FCWAY in rats. Here, we used (18)F-FCWAY to test the ability of the less toxic agent disulfiram to inhibit defluorination in humans. Eight healthy volunteers underwent a PET scan before and after administration of 500 mg of disulfiram (n = 6) or 2,000 mg of cimetidine (n = 2). Seven of the subjects had arterial blood sampling during both scans. Although cimetidine had relatively small and variable effects on 2 subjects, disulfiram reduced skull radioactivity by about 70% and increased peak brain uptake by about 50% (n = 5). Disulfiram decreased plasma-free (18)F-fluoride ion (from peak levels of 340% +/- 62% standardized uptake value (SUV) to 62% +/- 43% SUV; P < 0.01) and increased the concentration of the parent (18)F-FCWAY (with a corresponding decrease of clearance from 14.8 +/- 7.8 L x h(-1) at baseline to 7.9 +/- 2.8 L x h(-1) after drug treatment (P < 0.05). Using compartmental modeling with input of both (18)F-FCWAY and the radiometabolite (18)F-FC (trans-4-fluorocyclohexanecarboxylic acid), distribution volumes attributed to the parent radioligand unexpectedly decreased about 40%-60% after disulfiram, but the accuracy of the radiometabolite correction is uncertain. Disulfiram changed the shape of the brain time-activity curves in a manner that could occur with inhibition of the efflux transporter P-glycoprotein (P-gp). However, disulfiram showed no in vivo efficacy in monkeys to enhance the uptake of the known P-gp substrate (11)C-loperamide, suggesting that the effects of disulfiram in humans were mediated entirely by inhibition of CYP2E1. A single oral dose of disulfiram inhibited about 70% of the defluorination of (18)F-FCWAY, increased the plasma concentration of (18)F-FCWAY, increased brain uptake of activity, and resulted in better visualization of 5-HT(1A) receptor in the brain. Disulfiram is a safe and well-tolerated drug that may be useful for other radioligands that undergo defluorination via CYP2E1. JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine AU - Ryu, Yong Hoon AU - Liow, Jeih-San AU - Zoghbi, Sami AU - Fujita, Masahiro AU - Collins, Jerry AU - Tipre, Dnyanesh AU - Sangare, Janet AU - Hong, Jinsoo AU - Pike, Victor W AU - Innis, Robert B AD - Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 1154 EP - 1161 VL - 48 IS - 7 SN - 0161-5505, 0161-5505 KW - Cyclohexanes KW - 0 KW - Cytochrome P-450 CYP2E1 Inhibitors KW - Fluorine Radioisotopes KW - Ligands KW - N-(2-(4-(2-methoxyphenyl)piperazino))-N-(2-pyridinyl) trans-4-fluorocyclohexanecarboxamide KW - Piperazines KW - Radiopharmaceuticals KW - Receptor, Serotonin, 5-HT1A KW - 112692-38-3 KW - Cimetidine KW - 80061L1WGD KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - Disulfiram KW - TR3MLJ1UAI KW - Index Medicus KW - Skull -- metabolism KW - Animals KW - Fluorine Radioisotopes -- pharmacokinetics KW - Positron-Emission Tomography -- methods KW - Humans KW - Brain KW - Cytochrome P-450 CYP2E1 -- metabolism KW - Haplorhini KW - Adult KW - Cimetidine -- pharmacology KW - Middle Aged KW - Female KW - Male KW - Piperazines -- pharmacokinetics KW - Radiopharmaceuticals -- pharmacokinetics KW - Receptor, Serotonin, 5-HT1A -- metabolism KW - Disulfiram -- pharmacology KW - Cyclohexanes -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70687087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.atitle=Disulfiram+inhibits+defluorination+of+%2818%29F-FCWAY%2C+reduces+bone+radioactivity%2C+and+enhances+visualization+of+radioligand+binding+to+serotonin+5-HT1A+receptors+in+human+brain.&rft.au=Ryu%2C+Yong+Hoon%3BLiow%2C+Jeih-San%3BZoghbi%2C+Sami%3BFujita%2C+Masahiro%3BCollins%2C+Jerry%3BTipre%2C+Dnyanesh%3BSangare%2C+Janet%3BHong%2C+Jinsoo%3BPike%2C+Victor+W%3BInnis%2C+Robert+B&rft.aulast=Ryu&rft.aufirst=Yong&rft.date=2007-07-01&rft.volume=48&rft.issue=7&rft.spage=1154&rft.isbn=&rft.btitle=&rft.title=Journal+of+nuclear+medicine+%3A+official+publication%2C+Society+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-27 N1 - Date created - 2007-07-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J Nucl Med. 2008 Apr;49(4):596 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Visual appearance of the uterine cervix: correlation with human papillomavirus detection and type. AN - 70679640; 17618753 AB - Infection with carcinogenic human papillomaviruses (HPVs) is necessary for cervical precancer and cancer, but the effects of type-specific HPV infection on cervical appearance are poorly understood. Twenty expert colposcopists evaluated a total of 939 digitized cervigrams that were obtained during the ASCUS (atypical squamous cells of undetermined significance)-LSIL (low-grade squamous intraepithelial lesion) Triage study after the application of 5% acetic acid. Each reviewer rated the number and severity of lesions in 112 pictures that were matched on histologic diagnoses and HPV typing results so that > or = 2 reviewers rated each image. We used standard tests of association and correlation to relate HPV type and visual appearance. Pairs of reviewers were significantly (P < .05) more likely to agree that a definite lesion was present when HPV DNA was found, particularly HPV16, regardless of histologic diagnosis. However, the link between infection status and visual appearance was weak for each individual reviewer. Interestingly, many women with multiple HPV infections had no visible lesions and vice versa. HPV16 causes more definite visual abnormalities than other HPV types, regardless of eventual histologic diagnosis. Otherwise, the associations between HPV infection and lesion recognition are weak. JF - American journal of obstetrics and gynecology AU - Jeronimo, Jose AU - Massad, L Stewart AU - Schiffman, Mark AU - National Institutes of Health/American Society for Colposcopy and Cervical Pathology (NIH/ASCCP) Research Group AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA. guibovij@mail.nih.gov ; National Institutes of Health/American Society for Colposcopy and Cervical Pathology (NIH/ASCCP) Research Group Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 47.e1 EP - 8 VL - 197 IS - 1 KW - DNA, Viral KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Neoplasm Staging KW - DNA, Viral -- analysis KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - Female KW - Papillomavirus Infections -- diagnosis KW - Human papillomavirus 16 -- isolation & purification KW - Papillomavirus Infections -- complications KW - Uterine Cervical Neoplasms -- diagnosis KW - Papillomavirus Infections -- virology KW - Cervical Intraepithelial Neoplasia -- virology KW - Cervical Intraepithelial Neoplasia -- diagnosis KW - Colposcopy KW - Uterine Cervical Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70679640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+obstetrics+and+gynecology&rft.atitle=Visual+appearance+of+the+uterine+cervix%3A+correlation+with+human+papillomavirus+detection+and+type.&rft.au=Jeronimo%2C+Jose%3BMassad%2C+L+Stewart%3BSchiffman%2C+Mark%3BNational+Institutes+of+Health%2FAmerican+Society+for+Colposcopy+and+Cervical+Pathology+%28NIH%2FASCCP%29+Research+Group&rft.aulast=Jeronimo&rft.aufirst=Jose&rft.date=2007-07-01&rft.volume=197&rft.issue=1&rft.spage=47.e1&rft.isbn=&rft.btitle=&rft.title=American+journal+of+obstetrics+and+gynecology&rft.issn=1097-6868&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-06 N1 - Date created - 2007-07-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The IL-1 type 1 receptor is required for the development of LPS-induced airways disease. AN - 70678140; 17512577 AB - The contribution of IL-1beta signaling through the IL-1 type 1 receptor (IL-1R1) to the development of persistent LPS-induced airway disease has not been investigated. To determine the importance of signaling through the IL-1 type 1 receptor in the development of LPS-induced airway disease. We exposed IL-1R1-deficient (C57BL/6(IL-1RI-/-)) mice to an aerosol of LPS or filtered air for 1 day, 1 week, or 4 weeks. After 4 weeks of LPS inhalation, C57BL/6(IL-1RI-/-) mice failed to develop significant submucosal thickening, whereas C57BL/6 mice had significantly thickened submucosa in small, medium, and large airways compared with those of unexposed control mice. Cell proliferation in the airways of both the 1-week and 4-week LPS-exposed C57BL/6(IL-1RI-/-) mice was significantly reduced compared with LPS-exposed C57BL/6 mice. mRNA for type III alpha-3 procollagen was significantly elevated over baseline in C57BL/6 yet remained unchanged compared with baseline in C57BL/6(IL-1RI-/-) mice after 1 week or 4 weeks of LPS inhalation. mRNA for tissue inhibitor of metalloprotease 1 in C57BL/6 mice in the 1-week and 4-week groups was significantly elevated over both control mice and C57BL/6(IL-1RI-/-) mice. These data support the hypothesis that signaling through the IL-1 receptor modulates extracellular matrix homeostasis in response to inhaled LPS. Attenuating IL-1R1-mediated signaling might be an effective therapy against the development of airway remodeling in chronic inflammatory diseases. JF - The Journal of allergy and clinical immunology AU - Brass, David M AU - Hollingsworth, John W AU - Fessler, Michael B AU - Savov, Jordan D AU - Maxwell, Abby B AU - Whitehead, Gregory S AU - Burch, Lauranell H AU - Schwartz, David A AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. brassd@niehs.nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 121 EP - 127 VL - 120 IS - 1 SN - 0091-6749, 0091-6749 KW - Cytokines KW - 0 KW - Extracellular Matrix Proteins KW - Lipopolysaccharides KW - Receptors, Interleukin-1 Type I KW - Transforming Growth Factor beta1 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Neutrophil Activation KW - Transforming Growth Factor beta1 -- metabolism KW - Cytokines -- metabolism KW - Mice KW - Cell Proliferation KW - Mice, Knockout KW - Bronchoalveolar Lavage Fluid -- immunology KW - Extracellular Matrix Proteins -- metabolism KW - Extracellular Matrix Proteins -- genetics KW - Mice, Inbred C57BL KW - Male KW - Pneumonia -- immunology KW - Pneumonia -- chemically induced KW - Receptors, Interleukin-1 Type I -- genetics KW - Receptors, Interleukin-1 Type I -- physiology KW - Pneumonia -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70678140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=The+IL-1+type+1+receptor+is+required+for+the+development+of+LPS-induced+airways+disease.&rft.au=Brass%2C+David+M%3BHollingsworth%2C+John+W%3BFessler%2C+Michael+B%3BSavov%2C+Jordan+D%3BMaxwell%2C+Abby+B%3BWhitehead%2C+Gregory+S%3BBurch%2C+Lauranell+H%3BSchwartz%2C+David+A&rft.aulast=Brass&rft.aufirst=David&rft.date=2007-07-01&rft.volume=120&rft.issue=1&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=00916749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-04 N1 - Date created - 2007-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator-dependent system in gut. AN - 70677967; 17607366 AB - Cytochrome P450 1A1 (CYP1A1) is one of the most important detoxification enzymes due to its broad substrate specificity and wide distribution throughout the body. On the other hand, CYP1A1 can also produce highly carcinogenic intermediate metabolites through oxidation of polycyclic aromatic hydrocarbons. We describe what we believe to be a novel regulatory system for whole-body CYP1A1 expression by a factor originating in the gut. A mutant mouse was generated in which the arylhydrocarbon receptor nuclear translocator (Arnt) gene is disrupted predominantly in the gut epithelium. Surprisingly, CYP1A1 mRNA expression and enzymatic activities were markedly elevated in almost all non-gut tissues in this mouse line. The induction was even observed in early-stage embryos in pregnant mutant females. Interestingly, the upregulation was CYP1A1 selective and lost upon administration of a synthetic purified diet. Moreover, the increase was recovered by addition of the natural phytochemical indole-3-carbinol to the purified diet. These results suggest that an Arnt-dependent pathway in gut has an important role in regulation of the metabolism of dietary CYP1A1 inducers and whole-body CYP1A1 expression. This machinery might be involved in naturally occurring carcinogenic processes and/or other numerous biological responses mediated by CYP1A1 activity. JF - The Journal of clinical investigation AU - Ito, Shinji AU - Chen, Chi AU - Satoh, Junko AU - Yim, Sunhee AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 1940 EP - 1950 VL - 117 IS - 7 SN - 0021-9738, 0021-9738 KW - Arnt protein, mouse KW - 0 KW - Hif1a protein, mouse KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - Aryl Hydrocarbon Receptor Nuclear Translocator KW - 138391-32-9 KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Abridged Index Medicus KW - Index Medicus KW - Gene Expression Profiling KW - Animals KW - Active Transport, Cell Nucleus KW - Hypoxia-Inducible Factor 1, alpha Subunit -- genetics KW - Organ Specificity KW - Mice KW - Epithelium -- metabolism KW - Intestines -- metabolism KW - Mice, Transgenic KW - Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism KW - Feces KW - Plants -- chemistry KW - Cytochrome P-450 CYP1A1 -- genetics KW - Stomach -- metabolism KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Aryl Hydrocarbon Receptor Nuclear Translocator -- genetics KW - Aryl Hydrocarbon Receptor Nuclear Translocator -- metabolism KW - Cytochrome P-450 CYP1A1 -- metabolism KW - Diet KW - Stomach -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70677967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+investigation&rft.atitle=Dietary+phytochemicals+regulate+whole-body+CYP1A1+expression+through+an+arylhydrocarbon+receptor+nuclear+translocator-dependent+system+in+gut.&rft.au=Ito%2C+Shinji%3BChen%2C+Chi%3BSatoh%2C+Junko%3BYim%2C+Sunhee%3BGonzalez%2C+Frank+J&rft.aulast=Ito&rft.aufirst=Shinji&rft.date=2007-07-01&rft.volume=117&rft.issue=7&rft.spage=1940&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+investigation&rft.issn=00219738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-18 N1 - Date created - 2007-07-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicology. 2000 Nov 16;153(1-3):73-82 [11090948] Annu Rev Cell Dev Biol. 1999;15:551-78 [10611972] Carcinogenesis. 2006 Oct;27(10):2116-23 [16704990] Drug Metab Dispos. 2001 Jul;29(7):950-3 [11408359] Curr Drug Metab. 2001 Jun;2(2):149-64 [11469723] Nat Rev Cancer. 2006 Dec;6(12):947-60 [17128211] Carcinogenesis. 2007 Mar;28(3):732-7 [17052995] Carcinogenesis. 2007 Jun;28(6):1371-8 [17166882] Exp Physiol. 2006 Sep;91(5):803-6 [16740642] Mol Endocrinol. 2000 Oct;14(10):1674-81 [11043581] Biol Pharm Bull. 2001 Sep;24(9):1064-7 [11558570] Science. 2001 Oct 19;294(5542):605-9 [11567106] J Biol Chem. 2002 Sep 6;277(36):33275-83 [12065599] Am J Pathol. 2002 Oct;161(4):1439-47 [12368216] Am J Physiol Gastrointest Liver Physiol. 2003 Mar;284(3):G373-84 [12388200] J Pharmacol Exp Ther. 2003 Apr;305(1):315-22 [12649384] Arch Biochem Biophys. 2003 Jun 1;414(1):91-100 [12745259] J Nutr. 2003 Jul;133(7 Suppl):2470S-2475S [12840226] Mol Cell Biol. 2003 Oct;23(19):6739-49 [12972594] Eur J Drug Metab Pharmacokinet. 2003 Jan-Mar;28(1):41-8 [14503663] Drug Metab Dispos. 2003 Nov;31(11):1346-51 [14570766] Drug Metab Dispos. 2003 Dec;31(12):1520-5 [14625348] Cancer Res. 2004 Mar 1;64(5):1647-54 [14996723] Mol Pharmacol. 2004 May;65(5):1225-37 [15102951] J Biol Chem. 2004 Jun 4;279(23):23847-50 [15028720] Genesis. 2004 Jul;39(3):186-93 [15282745] Carcinogenesis. 2004 Sep;25(9):1771-8 [15105299] J Clin Invest. 2004 Oct;114(8):1098-106 [15489957] Cancer Res. 1975 Nov;35(11 Pt. 2):3326-31 [1104144] Cancer Res. 1986 Jan;46(1):94-8 [3753553] EMBO J. 1986 Dec 1;5(12):3119-24 [3453110] Mol Pharmacol. 1990 Sep;38(3):306-12 [2169579] Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9543-7 [1658785] Chem Res Toxicol. 1992 Mar-Apr;5(2):188-93 [1643248] Drug Metab Dispos. 1994 May-Jun;22(3):383-91 [8070314] J Biol Chem. 1994 Nov 4;269(44):27337-43 [7961644] Mol Pharmacol. 1994 Nov;46(5):915-21 [7969080] Genes Cells. 1997 Oct;2(10):645-54 [9427285] Carcinogenesis. 1999 Jan;20(1):109-14 [9934857] Annu Rev Pharmacol Toxicol. 1999;39:103-25 [10331078] Toxicol Sci. 2005 Feb;83(2):340-8 [15537747] Arch Biochem Biophys. 2005 Apr 1;436(1):50-61 [15752708] Bioinformatics. 2005 May 15;21(10):2430-7 [15774555] Annu Rev Biochem. 2005;74:115-28 [15952883] Biochem J. 2005 Aug 15;390(Pt 1):189-97 [15823097] Cell Cycle. 2005 Sep;4(9):1201-15 [16082211] Mol Pharmacol. 2006 Jan;69(1):140-53 [16214954] Mol Pharmacol. 2006 Apr;69(4):1103-14 [16377763] Mol Cell Endocrinol. 2006 Jul 25;254-255:179-86 [16781053] Pharmacol Rev. 2000 Dec;52(4):673-751 [11121513] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Polymorphisms of CD3epsilon in cynomolgus and rhesus monkeys and their relevance to anti-CD3 antibodies and immunotoxins. AN - 70677487; 17325695 AB - The monoclonal antibody FN18 has been used as a marker for monkey T cells and as a T-cell-depleting reagent when conjugated to diphtheria toxin that was mutated to prevent binding to non-targeted cells. The antibody recognizes a conformational epitope on the ectodomain of monkey CD3epsilon and displays a range of binding activity to the T cells from different rhesus and cynomolgus monkeys. Our quantitative fluorescence-activated cell sorting analysis of the FN18 reactivity to T cells from different rhesus and cynomolgus monkeys showed that there are at least three levels of FN18 reactivity in the monkeys tested: high, moderate and low. On the basis of available DNA sequence information, we determined the gene structure of rhesus CD3epsilon chain and designed primers that can be used to amplify and quickly sequence the ectodomain of monkey CD3epsilon. Our sequence analysis revealed that the extent of nucleotide sequence variation in this area is greater than that previously reported. In addition to the amino acids at positions 45 and 50, we demonstrated that position 35 of CD3epsilon was also important and substitution of amino acid A for V at this position greatly reduced T-cell reactivity to FN18. We found that T cells from monkeys with high FN18 reactivity all had V, E and R at positions 35, 45 and 50 in CD3epsilon, respectively; those having low FN18 reactivity were homozygous in CD3epsilon with at least one of the changes: V35 to A, E45 to G and R to 50Q, whereas members in the moderate group are heterozygous, having both V and A, E and G, R and Q at these locations. A cytotoxicity assay revealed that T cells from a heterozygous rhesus monkey with moderate FN18 reactivity were much (about 40 times) less sensitive to a FN18-derived immunotoxin than those from a homozygous rhesus monkey having high FN18 reactivity. JF - Immunology and cell biology AU - Liu, Yuan Yi AU - Wang, Zhirui AU - Thomas, Judith AU - Goodwin, K Jeanine AU - Stavrou, Scott AU - Neville, David M AD - Section on Biophysical Chemistry, Laboratory of Molecular Biology, National Institute of Mental Health, Bethesda, MD 20892, USA. yyliu@mail.nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 357 EP - 362 VL - 85 IS - 5 SN - 0818-9641, 0818-9641 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, CD3 KW - Immunoglobulin Variable Region KW - Immunotoxins KW - Mutant Proteins KW - Valine KW - HG18B9YRS7 KW - Alanine KW - OF5P57N2ZX KW - Index Medicus KW - Sequence Analysis, Protein KW - Animals KW - Immunoglobulin Variable Region -- metabolism KW - Enzyme-Linked Immunosorbent Assay KW - Protein Structure, Tertiary KW - Male KW - Cell Line KW - Mutant Proteins -- immunology KW - Antigens, CD3 -- immunology KW - Antigens, CD3 -- genetics KW - Antigens, CD3 -- chemistry KW - Polymorphism, Genetic KW - Immunotoxins -- immunology KW - Macaca mulatta -- genetics KW - Macaca fascicularis -- genetics KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70677487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunology+and+cell+biology&rft.atitle=Polymorphisms+of+CD3epsilon+in+cynomolgus+and+rhesus+monkeys+and+their+relevance+to+anti-CD3+antibodies+and+immunotoxins.&rft.au=Liu%2C+Yuan+Yi%3BWang%2C+Zhirui%3BThomas%2C+Judith%3BGoodwin%2C+K+Jeanine%3BStavrou%2C+Scott%3BNeville%2C+David+M&rft.aulast=Liu&rft.aufirst=Yuan&rft.date=2007-07-01&rft.volume=85&rft.issue=5&rft.spage=357&rft.isbn=&rft.btitle=&rft.title=Immunology+and+cell+biology&rft.issn=08189641&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-03 N1 - Date created - 2007-07-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene-air pollution interactions in asthma. AN - 70672060; 17607002 AB - Genetic and environmental factors interact to cause asthma. However, genetic studies have generally ignored environmental factors and environmental studies have generally ignored genetics. Thus, there are few examples from the literature of specific gene-environment interactions in relation to asthma. The clearest examples of genetic interactions for inhaled pollutants exist for endotoxin, environmental tobacco smoke, and ozone. Endotoxin-genetic interactions in asthma are the focus of two other manuscripts from this conference, so this review focuses on environmental tobacco smoke and ozone. In the sparse literature, there is evidence for the role of specific genes involved in oxidative stress, notably GSTM1 and TNF, in the respiratory responses to ozone and environmental tobacco smoke. There are few data on genes involved in innate immune pathways, which are crucial in response to endotoxin and may play a role in response to ozone and environmental tobacco smoke. Genes involved in oxidative stress may interact with both air pollutants and diet in relation to asthma phenotypes. Future directions to advance the field include whole genome association studies, better assessment of exposure and phenotypes, and consideration of joint interactions with diet and other co-factors that influence individual susceptibility. JF - Proceedings of the American Thoracic Society AU - London, Stephanie J AD - Epidemiology Branch and Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. London2@niehs.nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 217 EP - 220 VL - 4 IS - 3 SN - 1546-3222, 1546-3222 KW - Tobacco Smoke Pollution KW - 0 KW - Tumor Necrosis Factor-alpha KW - Ozone KW - 66H7ZZK23N KW - GSTP1 protein, human KW - EC 2.5.1.18 KW - Glutathione S-Transferase pi KW - Glutathione Transferase KW - glutathione S-transferase M1 KW - Index Medicus KW - Phenotype KW - Glutathione S-Transferase pi -- genetics KW - Genotype KW - Polymorphism, Genetic KW - Humans KW - Glutathione Transferase -- genetics KW - Genetic Predisposition to Disease KW - Tumor Necrosis Factor-alpha -- genetics KW - Asthma -- genetics KW - Tobacco Smoke Pollution -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70672060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+American+Thoracic+Society&rft.atitle=Gene-air+pollution+interactions+in+asthma.&rft.au=London%2C+Stephanie+J&rft.aulast=London&rft.aufirst=Stephanie&rft.date=2007-07-01&rft.volume=4&rft.issue=3&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+American+Thoracic+Society&rft.issn=15463222&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-18 N1 - Date created - 2007-07-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Respir Crit Care Med. 2001 May;163(6):1426-31 [11371413] Am J Respir Crit Care Med. 2006 Dec 15;174(12):1335-41 [17023730] Am J Respir Crit Care Med. 2002 Aug 15;166(4):457-63 [12186820] Toxicol Lett. 2002 Aug 5;134(1-3):219-25 [12191881] Nat Genet. 2003 Feb;33(2):177-82 [12524541] Am J Respir Crit Care Med. 2003 Apr 15;167(8):1083-9 [12522030] J Allergy Clin Immunol. 2003 Apr;111(4):840-6 [12704367] JAMA. 2003 Oct 8;290(14):1859-67 [14532314] JAMA. 2003 Oct 8;290(14):1915-7 [14532321] Am J Respir Crit Care Med. 2003 Nov 15;168(10):1199-204 [12969868] Thorax. 2004 Jan;59(1):8-10 [14694237] Thorax. 2004 Apr;59(4):295-302 [15047948] Am J Respir Cell Mol Biol. 2004 Jul;31(1):69-77 [14975936] Am J Respir Crit Care Med. 2004 Jul 15;170(2):126-32 [15020293] Am J Respir Crit Care Med. 2004 Aug 1;170(3):279-87 [15117740] Pharmacogenetics. 1991 Nov;1(2):110-3 [1844868] Am J Respir Crit Care Med. 1996 Jan;153(1):3-50 [8542133] Environ Health Perspect. 2007 Apr;115(4):616-22 [17450233] Nat Genet. 1997 Dec;17(4):471-4 [9398853] Nat Genet. 1997 Dec;17(4):475-8 [9398854] Am J Respir Crit Care Med. 1998 Jul;158(1):226-32 [9655734] Am J Respir Crit Care Med. 2005 Jan 15;171(2):171-6 [15486341] J Allergy Clin Immunol. 2005 Jun;115(6):1169-75 [15940130] Am J Respir Crit Care Med. 2005 Jul 15;172(2):173-82 [15879416] Thorax. 2005 Dec;60(12):1052-8 [16131525] Am J Respir Crit Care Med. 2005 Dec 15;172(12):1563-8 [16166621] Am J Respir Crit Care Med. 2006 Feb 1;173(3):264-70 [16239624] Genes Immun. 2006 Mar;7(2):95-100 [16395390] Environ Health Perspect. 2006 Apr;114(4):627-33 [16581557] Am J Physiol Lung Cell Mol Physiol. 2006 May;290(5):L931-45 [16361358] Am J Respir Crit Care Med. 2006 May 1;173(9):970-6 [16456144] Pediatrics. 2006 Aug;118(2):710-6 [16882827] Lancet. 2006 Aug 26;368(9537):733-43 [16935684] Eur Respir J. 2006 Nov;28(5):953-9 [16870661] Epidemiology. 2001 Sep;12(5):577-83 [11505179] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Preeclampsia risk in women exposed in utero to diethylstilbestrol. AN - 70667429; 17601905 AB - To assess whether preeclampsia risk is elevated in pregnancies of diethylstilbestrol (DES)-exposed daughters. This study used data from the National Cancer Institute DES Combined Cohorts Follow-up Study. A total of 285 preeclampsia cases (210 exposed and 75 unexposed) occurred in 7,313 live births (4,759 DES exposed and 2,554 unexposed). Poisson regression analysis estimated relative risks and 95% confidence intervals (CI) for preeclampsia adjusted for age at the index pregnancy, parity, education, smoking, body mass index, year of diagnosis, and cohort. In utero DES exposure was associated with nearly a 50% elevation in preeclampsia risk. Adjustment for preeclampsia risk factors attenuated the relative risk slightly (1.42, 95% CI 1.04-1.94). The excess risk with DES was concentrated among women who developed preeclampsia in their first pregnancies (relative risk 1.81, 95% CI 1.17-2.79), who were exposed before 15 weeks of gestation (relative risk 1.57, 95% CI 1.11-2.23), and who were treated with magnesium sulfate (relative risk 2.10, 95% CI 0.82-5.42). Among DES-exposed women who had a prior hysterosalpingogram, preeclampsia prevalence was higher in those with uterine abnormalities (12.4%) than in those without (7.7%). These data suggest that in utero exposure to DES is associated with a slightly elevated risk of preeclampsia, and that one possible biological mechanism involves uterine abnormalities. JF - Obstetrics and gynecology AU - Troisi, Rebecca AU - Titus-Ernstoff, Linda AU - Hyer, Marianne AU - Hatch, Elizabeth E AU - Robboy, Stanley J AU - Strohsnitter, William AU - Palmer, Julie R AU - Øglaend, Bjørn AU - Adam, Ervin AU - Kaufman, Raymond AU - Herbst, Arthur L AU - Hoover, Robert N AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. troisir@mail.nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 113 EP - 120 VL - 110 IS - 1 SN - 0029-7844, 0029-7844 KW - Estrogens, Non-Steroidal KW - 0 KW - Diethylstilbestrol KW - 731DCA35BT KW - Abridged Index Medicus KW - Index Medicus KW - Risk Factors KW - Humans KW - Health Surveys KW - Cohort Studies KW - Adult KW - Uterus -- abnormalities KW - Follow-Up Studies KW - Uterus -- drug effects KW - Female KW - Proportional Hazards Models KW - Pregnancy KW - Diethylstilbestrol -- adverse effects KW - Pre-Eclampsia -- epidemiology KW - Pre-Eclampsia -- chemically induced KW - Estrogens, Non-Steroidal -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70667429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obstetrics+and+gynecology&rft.atitle=Preeclampsia+risk+in+women+exposed+in+utero+to+diethylstilbestrol.&rft.au=Troisi%2C+Rebecca%3BTitus-Ernstoff%2C+Linda%3BHyer%2C+Marianne%3BHatch%2C+Elizabeth+E%3BRobboy%2C+Stanley+J%3BStrohsnitter%2C+William%3BPalmer%2C+Julie+R%3B%C3%98glaend%2C+Bj%C3%B8rn%3BAdam%2C+Ervin%3BKaufman%2C+Raymond%3BHerbst%2C+Arthur+L%3BHoover%2C+Robert+N&rft.aulast=Troisi&rft.aufirst=Rebecca&rft.date=2007-07-01&rft.volume=110&rft.issue=1&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Obstetrics+and+gynecology&rft.issn=00297844&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-31 N1 - Date created - 2007-07-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Association between a functional serotonin transporter promoter polymorphism and citalopram treatment in adult outpatients with major depression. AN - 70664112; 17606812 AB - The HTTLPR, a functional polymorphism of the serotonin transporter gene solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4), promoter, affects transcription and may be involved in antidepressant drug treatment outcome, although response rates with antidepressants can be lower in patients who experience adverse effects. To test the hypothesis that HTTLPR is associated with treatment outcome to citalopram. A clinical effectiveness trial, Sequenced Treatment Alternatives to Relieve Depression, collected DNA samples from outpatients with nonpsychotic major depressive disorder who received citalopram in the first treatment step. The triallelic HTTLPR locus was genotyped in 1775 samples to discriminate between long (L) and short (S) alleles, followed by the A > G substitution. The low-expression S and L(G) alleles were grouped together compared with the high-expression L(A) allele. Eighteen primary care and 23 psychiatric care sites across the United States. Ages 18 to 75 years, meeting criteria for single or recurrent nonpsychotic major depression. Categorical response, remission, tolerance, and adverse effect burden. Expression-based grouping produced a significant finding of association between the L(A) allele and adverse effect burden in the entire sample (P = .004 [genotype frequency]; P < .001 [allele frequency]). To control for bias from population stratification, a white American subsample was analyzed. A lesser adverse effect burden was associated with L(A)L(A) genotype frequency (P = .03) or L(A) allele frequency (P = .007). These findings in white patients did not hold when the L allele was undifferentiated. No association was observed between treatment outcome phenotypes and HTTLPR. Development of diarrhea and the presence of the low-expression S or L(G) alleles were the strongest risk factors associated with adverse effect burden. The HTTLPR polymorphism is associated with citalopram adverse effects. Because the L(A) allele confers increased SLC6A4 transcription, increased serotonin transporter levels in brain and other tissues may lead to fewer adverse effects for antidepressant medications that target the transporter. JF - Archives of general psychiatry AU - Hu, Xian-Zhang AU - Rush, A John AU - Charney, Dennis AU - Wilson, Alexander F AU - Sorant, Alexa J M AU - Papanicolaou, George J AU - Fava, Maurizio AU - Trivedi, Madhukar H AU - Wisniewski, Stephen R AU - Laje, Gonzalo AU - Paddock, Silvia AU - McMahon, Francis J AU - Manji, Husseini AU - Lipsky, Robert H AD - Section on Molecular Genetics, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 783 EP - 792 VL - 64 IS - 7 SN - 0003-990X, 0003-990X KW - SLC6A4 protein, human KW - 0 KW - Serotonin Plasma Membrane Transport Proteins KW - Serotonin Uptake Inhibitors KW - Citalopram KW - 0DHU5B8D6V KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Transcription, Genetic -- genetics KW - Aged KW - Ambulatory Care KW - Genotype KW - Phenotype KW - Alleles KW - Prospective Studies KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Promoter Regions, Genetic -- genetics KW - Adolescent KW - Female KW - Male KW - Citalopram -- therapeutic use KW - Depressive Disorder, Major -- drug therapy KW - Polymorphism, Genetic KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Serotonin Plasma Membrane Transport Proteins -- genetics KW - Depressive Disorder, Major -- genetics KW - Serotonin Uptake Inhibitors -- adverse effects KW - Citalopram -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70664112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=Association+between+a+functional+serotonin+transporter+promoter+polymorphism+and+citalopram+treatment+in+adult+outpatients+with+major+depression.&rft.au=Hu%2C+Xian-Zhang%3BRush%2C+A+John%3BCharney%2C+Dennis%3BWilson%2C+Alexander+F%3BSorant%2C+Alexa+J+M%3BPapanicolaou%2C+George+J%3BFava%2C+Maurizio%3BTrivedi%2C+Madhukar+H%3BWisniewski%2C+Stephen+R%3BLaje%2C+Gonzalo%3BPaddock%2C+Silvia%3BMcMahon%2C+Francis+J%3BManji%2C+Husseini%3BLipsky%2C+Robert+H&rft.aulast=Hu&rft.aufirst=Xian-Zhang&rft.date=2007-07-01&rft.volume=64&rft.issue=7&rft.spage=783&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-20 N1 - Date created - 2007-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Assessing intraepithelial neoplasia and drug safety in cancer-preventive drug development. AN - 70662714; 17568791 AB - Despite significant interest from the research community and the population in general, drug approvals for cancer prevention and/or cancer risk reduction are few. This is due, in part, to the requirement that new cancer-preventive drugs must first be shown to be efficacious in reducing cancer incidence or mortality. Moreover, such drugs need to have proven safety for long-term administration. This process can be improved by focusing on precancer (intraepithelial neoplasia) to identify subjects at risk and prove efficacy in shorter, smaller trials as well as on detecting early markers of potential toxicities of chronic exposure to cancer-preventive drug regimens. JF - Nature reviews. Cancer AU - Kelloff, Gary J AU - Sigman, Caroline C AD - National Institutes of Health, National Cancer Institute, Division of Cancer Treatment and Diagnosis, Executive Plaza North Room 6058, 6130 Executive Boulevard, Rockville, Maryland 20852, USA. kelloffg@mail.nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 508 EP - 518 VL - 7 IS - 7 SN - 1474-175X, 1474-175X KW - Anticarcinogenic Agents KW - 0 KW - Index Medicus KW - Risk Reduction Behavior KW - Humans KW - Safety KW - Precancerous Conditions -- prevention & control KW - Precancerous Conditions -- pathology KW - Anticarcinogenic Agents -- therapeutic use KW - Carcinoma in Situ -- genetics KW - Carcinoma in Situ -- epidemiology KW - Carcinoma in Situ -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70662714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+reviews.+Cancer&rft.atitle=Assessing+intraepithelial+neoplasia+and+drug+safety+in+cancer-preventive+drug+development.&rft.au=Kelloff%2C+Gary+J%3BSigman%2C+Caroline+C&rft.aulast=Kelloff&rft.aufirst=Gary&rft.date=2007-07-01&rft.volume=7&rft.issue=7&rft.spage=508&rft.isbn=&rft.btitle=&rft.title=Nature+reviews.+Cancer&rft.issn=1474175X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-17 N1 - Date created - 2007-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Isolation of a mesenchymal cell population from murine dermis that contains progenitors of multiple cell lineages. AN - 70661372; 17384147 AB - The skin contains two known subpopulations of stem cells/epidermal progenitors: a basal keratinocyte population found in the interfollicular epithelium and cells residing in the bulge region of the hair follicle. The major role of the interfollicular basal keratinocyte population may be epidermal renewal, whereas the bulge population may only be activated and recruited to form a cutaneous epithelium in case of trauma. Using 3-dimensional cultures of murine skin under stress conditions in which only reserve epithelial cells would be expected to survive and expand, we demonstrate that a mesenchymal population resident in neonatal murine dermis has the unique potential to develop an epidermis in vitro. In monolayer culture, this dermal subpopulation has long-term survival capabilities in restricted serum and an inducible capacity to evolve into multiple cell lineages, both epithelial and mesenchymal, depending on culture conditions. When grafted subcutaneously, this dermal subpopulation gave rise to fusiform structures, reminiscent of disorganized muscle, that stained positive for smooth muscle actin and desmin; on typical epidermal grafts, abundant melanocytes appeared throughout the dermis that were not associated with hair follicles. The multipotential cells can be repeatedly isolated from neonatal murine dermis by a sequence of differential centrifugation and selective culture conditions. These results suggest that progenitors capable of epidermal differentiation exist in the mesenchymal compartment of an abundant tissue source and may have a function in mesenchymal-epithelial transition upon insult. Moreover, these cells could be available in sufficient quantities for lineage determination or tissue engineering applications. JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology AU - Crigler, Lauren AU - Kazhanie, Amita AU - Yoon, Tae-Jin AU - Zakhari, Julia AU - Anders, Joanna AU - Taylor, Barbara AU - Virador, Victoria M AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA. Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 2050 EP - 2063 VL - 21 IS - 9 KW - Antigens, CD KW - 0 KW - Culture Media KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Antigens, CD -- analysis KW - Animals KW - Cell Lineage KW - Cells, Cultured -- cytology KW - Calcium -- pharmacology KW - Cells, Cultured -- transplantation KW - Mice, Inbred BALB C KW - Osteoblasts -- cytology KW - Culture Media -- pharmacology KW - Epithelial Cells -- cytology KW - Chondrocytes -- cytology KW - Injections, Subcutaneous KW - Mesenchymal Stem Cell Transplantation KW - Keratinocytes -- cytology KW - Flow Cytometry KW - Cell Division KW - Myoblasts -- cytology KW - Epidermis -- cytology KW - Cell Differentiation KW - Mice KW - Adipocytes -- cytology KW - Centrifugation -- methods KW - Animals, Newborn KW - Gene Expression Profiling KW - Cell Culture Techniques -- methods KW - Colony-Forming Units Assay KW - Stress, Physiological KW - Dermis -- cytology KW - Hair Follicle -- cytology KW - Mesenchymal Stromal Cells -- physiology KW - Multipotent Stem Cells -- transplantation KW - Multipotent Stem Cells -- physiology KW - Tissue Engineering -- methods KW - Cell Separation -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70661372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.atitle=Isolation+of+a+mesenchymal+cell+population+from+murine+dermis+that+contains+progenitors+of+multiple+cell+lineages.&rft.au=Crigler%2C+Lauren%3BKazhanie%2C+Amita%3BYoon%2C+Tae-Jin%3BZakhari%2C+Julia%3BAnders%2C+Joanna%3BTaylor%2C+Barbara%3BVirador%2C+Victoria+M&rft.aulast=Crigler&rft.aufirst=Lauren&rft.date=2007-07-01&rft.volume=21&rft.issue=9&rft.spage=2050&rft.isbn=&rft.btitle=&rft.title=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.issn=1530-6860&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-15 N1 - Date created - 2007-06-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Dev Dyn. 2004 Jan;229(1):99-108 [14699581] J Invest Dermatol. 2003 Nov;121(5):1095-103 [14708612] Science. 2004 Jan 16;303(5656):359-63 [14671312] Nature. 2004 Mar 11;428(6979):133-4 [15014482] J Invest Dermatol. 2004 Aug;123(2):275-82 [15245425] Cell Physiol Biochem. 2004;14(4-6):311-24 [15319535] J Biol Chem. 2004 Oct 15;279(42):43725-34 [15302865] Experientia. 1983 Oct 15;39(10):1125-9 [6617813] J Invest Dermatol. 1987 Oct;89(4):369-79 [2822817] J Invest Dermatol. 1990 Dec;95(6):657-64 [2123494] Cell Tissue Kinet. 1990 Nov;23(6):587-602 [2177380] J Invest Dermatol. 1991 May;96(5):81S-82S [2022891] J Cell Biol. 1993 Jan;120(1):217-25 [7678013] J Invest Dermatol. 1993 Mar;100(3):229-36 [8440892] J Invest Dermatol. 1993 Jul;101(1 Suppl):124S-129S [8326145] J Invest Dermatol. 1993 Jul;101(1 Suppl):27S-32S [8326151] Methods Enzymol. 1995;254:3-20 [8531694] Cancer Lett. 1995 Nov 27;98(1):103-10 [8529197] J Exp Med. 1996 Apr 1;183(4):1797-806 [8666936] J Invest Dermatol. 1996 Jul;107(1):121-7 [8752850] Science. 1997 Feb 14;275(5302):964-7 [9020076] Pediatr Res. 1997 Feb;41(2):285-92 [9029652] Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3902-7 [9520465] Philos Trans R Soc Lond B Biol Sci. 1998 Jun 29;353(1370):831-7 [9684280] J Cell Sci. 1998 Nov;111 ( Pt 21):3179-88 [9763512] J Cell Biol. 1998 Oct 19;143(2):469-86 [9786956] Nature. 1999 Apr 22;398(6729):708-13 [10227293] Nat Cell Biol. 2004 Nov;6(11):1082-93 [15517002] Differentiation. 2004 Oct;72(8):371-80 [15606496] Differentiation. 2004 Oct;72(8):387-95 [15606498] Dev Dyn. 2005 Feb;232(2):293-300 [15614782] Exp Cell Res. 2005 Mar 10;304(1):81-90 [15707576] J Biol Chem. 2005 Mar 4;280(9):8094-100 [15591043] Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5530-4 [15802470] J Invest Dermatol. 2005 May;124(5):867-76 [15854024] Trends Cardiovasc Med. 2005 Feb;15(2):57-63 [15885571] Pigment Cell Res. 2005 Jun;18(3):167-80 [15892713] FEBS J. 2005 Jun;272(11):2811-27 [15943814] Curr Opin Otolaryngol Head Neck Surg. 2005 Aug;13(4):233-41 [16012248] Curr Opin Genet Dev. 2005 Aug;15(4):371-80 [15950454] Nat Rev Mol Cell Biol. 2005 Sep;6(9):726-37 [16103873] J Cell Physiol. 2006 Mar;206(3):831-42 [16245313] Nat Med. 2006 Apr;12(4):459-65 [16582917] J Cell Biochem. 2006 May 1;98(1):174-84 [16408300] J Invest Dermatol. 1995 May;104(5 Suppl):21S-22S [7738378] J Invest Dermatol. 1995 May;104(5 Suppl):43S-44S [7738395] Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3156-61 [11248048] J Invest Dermatol. 2001 May;116(5):816-20 [11348477] Nat Med. 2001 Sep;7(9):1028-34 [11533706] Mol Cell Biol. 1999 Dec;19(12):8547-58 [10567579] Exp Dermatol. 2000 Feb;9(1):20-4 [10688371] Cancer Res. 2000 Jul 1;60(13):3328-32 [10910032] Cell. 2000 Aug 18;102(4):451-61 [10966107] Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10960-5 [11005869] Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13473-5 [11087834] Exp Dermatol. 2001 Feb;10(1):45-54 [11168579] J Biol Chem. 2001 Sep 21;276(38):35818-25 [11463791] Histochem Cell Biol. 2001 Oct;116(4):287-97 [11702187] Nature. 2002 Apr 25;416(6883):854-60 [11976685] Genes Dev. 2002 Jun 1;16(11):1412-22 [12050118] Leukemia. 2003 Jan;17(1):160-70 [12529674] J Invest Dermatol. 2003 Apr;120(4):501-11 [12648211] Biotechniques. 2003 Mar;34(3):572-8, 580-4, 586-91 [12661162] J Cell Sci. 2003 Jul 15;116(Pt 14):2937-48 [12771184] J Cell Biochem. 2003 Aug 15;89(6):1235-49 [12898521] J Cell Sci. 2003 Oct 15;116(Pt 20):4239-48 [12953062] Development. 2003 Nov;130(22):5493-501 [14530295] Int J Cancer. 2004 Jan 20;108(3):348-57 [14648700] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Vasoactive intestinal peptide antagonist treatment during mouse embryogenesis impairs social behavior and cognitive function of adult male offspring. AN - 70659014; 17521630 AB - Vasoactive intestinal peptide (VIP) is a regulator of rodent embryogenesis during the period of neural tube closure. VIP enhanced growth in whole cultured mouse embryos; treatment with a VIP antagonist during embryogenesis inhibited growth and development. VIP antagonist treatment during embryogenesis also had permanent effects on adult brain chemistry and impaired social recognition behavior in adult male mice. The neurological deficits of autism appear to be initiated during neural tube closure and social behavior deficits are among the key characteristics of this disorder that is more common in males and is frequently accompanied by mental retardation. The current study examined the blockage of VIP during embryogenesis as a model for the behavioral deficits of autism. Treatment of pregnant mice with a VIP antagonist during embryonic days 8 through 10 had no apparent effect on the general health or sensory or motor capabilities of adult offspring. However, male offspring exhibited reduced sociability in the social approach task and deficits in cognitive function, as assessed through cued and contextual fear conditioning. Female offspring did not show these deficiencies. These results suggest that this paradigm has usefulness as a mouse model for aspects of autism as it selectively impairs male offspring who exhibit the reduced social behavior and cognitive dysfunction seen in autism. Furthermore, the study indicates that the foundations of some aspects of social behavior are laid down early in mouse embryogenesis, are regulated in a sex specific manner and that interference with embryonic regulators such as VIP can have permanent effects on adult social behavior. JF - Experimental neurology AU - Hill, Joanna M AU - Cuasay, Katrina AU - Abebe, Daniel T AD - Laboratory of Behavioral Neuroscience, NIMH, NIH, Bethesda, MD 21029, USA. hilljoa@mail.nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 101 EP - 113 VL - 206 IS - 1 SN - 0014-4886, 0014-4886 KW - Peptides KW - 0 KW - Vasoactive Intestinal Peptide KW - 37221-79-7 KW - Index Medicus KW - Animals KW - Habituation, Psychophysiologic -- drug effects KW - Avoidance Learning -- physiology KW - Sex Characteristics KW - Social Behavior KW - Disease Models, Animal KW - Mice KW - Avoidance Learning -- drug effects KW - Peptides -- pharmacology KW - Pregnancy KW - Aging -- physiology KW - Cognition -- physiology KW - Habituation, Psychophysiologic -- physiology KW - Animals, Newborn KW - Cognition -- drug effects KW - Smell -- drug effects KW - Smell -- physiology KW - Female KW - Male KW - Cognition Disorders -- metabolism KW - Prenatal Exposure Delayed Effects -- metabolism KW - Vasoactive Intestinal Peptide -- metabolism KW - Brain -- drug effects KW - Mental Disorders -- chemically induced KW - Cognition Disorders -- chemically induced KW - Mental Disorders -- metabolism KW - Mental Disorders -- physiopathology KW - Brain -- physiopathology KW - Vasoactive Intestinal Peptide -- antagonists & inhibitors KW - Autistic Disorder -- etiology KW - Prenatal Exposure Delayed Effects -- chemically induced KW - Brain -- embryology KW - Prenatal Exposure Delayed Effects -- physiopathology KW - Cognition Disorders -- physiopathology KW - Autistic Disorder -- metabolism KW - Autistic Disorder -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70659014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+neurology&rft.atitle=Vasoactive+intestinal+peptide+antagonist+treatment+during+mouse+embryogenesis+impairs+social+behavior+and+cognitive+function+of+adult+male+offspring.&rft.au=Hill%2C+Joanna+M%3BCuasay%2C+Katrina%3BAbebe%2C+Daniel+T&rft.aulast=Hill&rft.aufirst=Joanna&rft.date=2007-07-01&rft.volume=206&rft.issue=1&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Experimental+neurology&rft.issn=00144886&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-17 N1 - Date created - 2007-06-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interleukin 10 and TNFalpha synergistically enhance the expression of the G protein-coupled formylpeptide receptor 2 in microglia. AN - 70652828; 17544285 AB - Microglia are important participants in inflammatory responses in the central nervous system. We previously observed that tumor necrosis factor alpha (TNFalpha) induces the expression of the formylpeptide receptor mFPR2 on microglial cells. This chemoattractant receptor mediates microglial cell chemotaxis in response to a variety of peptides, including amyloid beta peptide (Abeta(42)), a major pathogenic factor in Alzheimer's disease (AD). In search for agents that regulate microglial activation, we unexpectedly found that IL-10 enhanced the expression of mFPR2 on TNFalpha-activated microglia. This was associated with a markedly increased microglial chemotaxis to Abeta(42) and its endocytosis via mFPR2. Mechanistic studies revealed that the synergistic effect of IL-10 on TNFalpha-induction of mFPR2 in microglia was dependent on activation of p38 MAPK. Our results suggest that IL-10 may affect the pathogenic process of AD by up-regulating mFPR2 and thus favoring the recognition and internalization of Abeta(42) by activated microglial cells. JF - Neurobiology of disease AU - Iribarren, Pablo AU - Chen, Keqiang AU - Gong, Wanghua AU - Cho, Edward H AU - Lockett, Stephen AU - Uranchimeg, Badarch AU - Wang, Ji Ming AD - Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA. piribarr@mail.fcq.unc.edu.ar Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 90 EP - 98 VL - 27 IS - 1 SN - 0969-9961, 0969-9961 KW - Amyloid beta-Peptides KW - 0 KW - Histocompatibility Antigens Class II KW - Peptide Fragments KW - Receptors, Formyl Peptide KW - Tumor Necrosis Factor-alpha KW - amyloid beta-protein (1-42) KW - formyl peptide receptor 2, mouse KW - Interleukin-10 KW - 130068-27-8 KW - p38 Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Histocompatibility Antigens Class II -- genetics KW - Amyloid beta-Peptides -- pharmacokinetics KW - Neuroimmunomodulation -- physiology KW - Mice KW - p38 Mitogen-Activated Protein Kinases -- metabolism KW - Gene Expression -- immunology KW - Mice, Inbred C57BL KW - Chemotaxis -- drug effects KW - Drug Synergism KW - Peptide Fragments -- pharmacokinetics KW - Cell Line KW - Receptors, Formyl Peptide -- metabolism KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Tumor Necrosis Factor-alpha -- immunology KW - Microglia -- immunology KW - Microglia -- cytology KW - Interleukin-10 -- immunology KW - Interleukin-10 -- pharmacology KW - Microglia -- drug effects KW - Receptors, Formyl Peptide -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70652828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurobiology+of+disease&rft.atitle=Interleukin+10+and+TNFalpha+synergistically+enhance+the+expression+of+the+G+protein-coupled+formylpeptide+receptor+2+in+microglia.&rft.au=Iribarren%2C+Pablo%3BChen%2C+Keqiang%3BGong%2C+Wanghua%3BCho%2C+Edward+H%3BLockett%2C+Stephen%3BUranchimeg%2C+Badarch%3BWang%2C+Ji+Ming&rft.aulast=Iribarren&rft.aufirst=Pablo&rft.date=2007-07-01&rft.volume=27&rft.issue=1&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Neurobiology+of+disease&rft.issn=09699961&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-06 N1 - Date created - 2007-06-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 2001 Jan 1;166(1):602-8 [11123343] J Immunol. 2005 Nov 1;175(9):6100-6 [16237106] J Neurosci. 2001 Jan 15;21(2):RC123 [11160457] Brain Res. 2001 Mar 9;894(1):21-30 [11245811] Cytokine Growth Factor Rev. 2001 Mar;12(1):91-105 [11312121] Nat Med. 2001 May;7(5):612-8 [11329064] Neurobiol Aging. 2001 May-Jun;22(3):427-34 [11378249] Infect Immun. 2001 Jul;69(7):4561-71 [11402000] J Biol Chem. 2001 Jun 29;276(26):23645-52 [11316806] Neurochem Int. 2001 Nov-Dec;39(5-6):333-40 [11578768] FASEB J. 2001 Nov;15(13):2454-62 [11689470] J Immunol. 2002 Jan 1;168(1):434-42 [11751990] J Neuroimmunol. 2002 Jan;122(1-2):9-19 [11777539] Curr Med Chem. 2002 Jan;9(1):83-8 [11860350] Ernst Schering Res Found Workshop. 2002;(39):105-32 [12066408] Science. 2002 Jul 19;297(5580):353-6 [12130773] J Neurol Sci. 2002 Oct 15;202(1-2):13-23 [12220687] Neurobiol Dis. 2002 Aug;10(3):366-77 [12270697] J Leukoc Biol. 2002 Oct;72(4):628-35 [12377930] Glia. 2002 Nov;40(2):175-83 [12379905] Trends Immunol. 2002 Nov;23(11):541-8 [12401407] FASEB J. 2005 Dec;19(14):2032-4 [16219804] J Biol Chem. 2006 Feb 10;281(6):3651-9 [16339765] J Neurosci. 2003 May 1;23(9):3745-51 [12736345] Ann N Y Acad Sci. 2003 Jun;991:214-28 [12846989] J Neurosci. 2003 Nov 26;23(34):10879-83 [14645482] J Immunol. 2004 Jun 1;172(11):7078-85 [15153530] J Immunol. 2004 Jul 15;173(2):962-8 [15240683] Glia. 1993 Jan;7(1):34-40 [8423060] Cell. 1993 Oct 22;75(2):263-74 [8402911] J Immunol. 1999 Dec 15;163(12):6777-84 [10586077] Nat Med. 2000 Aug;6(8):916-9 [10932230] Adv Immunol. 1994;56:1-26 [8073945] J Immunol. 1995 Aug 1;155(3):1525-33 [7636214] J Immunol. 1995 Dec 1;155(11):5397-401 [7594556] Neurobiol Aging. 1996 Mar-Apr;17(2):311-21 [8744413] Nature. 1996 Aug 22;382(6593):685-91 [8751438] Nature. 1996 Aug 22;382(6593):716-9 [8751442] Neuron. 1996 Sep;17(3):553-65 [8816718] J Neurosci Res. 1996 Jan 15;43(2):190-202 [8820967] J Exp Med. 1998 Feb 2;187(3):439-44 [9449724] Exp Neurol. 1998 Feb;149(2):329-40 [9500964] J Biol Chem. 1998 May 15;273(20):12219-26 [9575170] Neurosci Lett. 1998 Jul 31;251(3):189-92 [9726375] J Clin Invest. 1999 Mar;103(6):807-15 [10079101] Nature. 1999 Jul 8;400(6740):173-7 [10408445] Nat Rev Immunol. 2005 Jan;5(1):69-81 [15630430] Immunol Res. 2005;31(3):165-76 [15888909] J Neuroimmunol. 2005 Oct;167(1-2):90-8 [16095726] J Immunol. 2001 Jan 15;166(2):966-72 [11145674] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Issues in the pharmacological treatment of obsessive-compulsive disorder. AN - 70624033; 17511795 AB - Obsessive-compulsive disorder (OCD) preferentially responds to a class of antidepressants called serotonin reuptake inhibitors (SRI). This review discusses certain issues unique to pharmacological treatment of OCD: choice of SRI, dose and duration of treatment, options after first failed SRI trial and treatment of SRI non-responders. We performed a MEDLINE search for pharmacotherapy studies published until December 2006. In addition, the reference sections of major articles, and reviews were also screened. We also considered clinical guidelines and narrative reviews in writing this review. The SRIs are equally effective in treating OCD. Meta-analyses suggest that clomipramine may be superior to other SRIs. OCD tends to respond to higher doses of SRIs than that used to treat depression. Response to treatment is usually delayed and may take up to 8-12 weeks. Atypical antipsychotics are the only proven augmenting agents in SRI non-responders. Cognitive behaviour therapy (CBT) is an effective treatment strategy in treating OCD and possibly has a role in treating SRI non-responders. Side effect profile and drug-drug interactions largely determine the choice of SRI. Those who fail to respond to one SRI trial may well respond to another SRI trial. Clomipramine is recommended if 2-3 trials of SRIs fail to produce response. Atypical antipsychotics are the first-line augmenting agents in SRI non-responders. CBT should be considered in all patients with OCD and is a potential option in SRI non-responders. OCD is a chronic and debilitating disorder. In responders, SRIs have to be continued in the same doses (if possible) for a minimum of 1-2 years and may be lifelong in those with persistent symptoms and in those with multiple relapses. CBT has to be offered in combination with SRIs wherever facilities for CBT exist. JF - International journal of clinical practice AU - Math, S B AU - Janardhan Reddy, Y C AD - OCD clinic, Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bangalore, India. Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 1188 EP - 1197 VL - 61 IS - 7 SN - 1368-5031, 1368-5031 KW - Serotonin Uptake Inhibitors KW - 0 KW - Clomipramine KW - NUV44L116D KW - Index Medicus KW - Drug Interactions KW - Diagnosis, Differential KW - Combined Modality Therapy KW - Humans KW - Treatment Outcome KW - Recurrence KW - Obsessive-Compulsive Disorder -- diagnosis KW - Cognitive Therapy KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Obsessive-Compulsive Disorder -- therapy KW - Clomipramine -- adverse effects KW - Serotonin Uptake Inhibitors -- adverse effects KW - Clomipramine -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70624033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+clinical+practice&rft.atitle=Issues+in+the+pharmacological+treatment+of+obsessive-compulsive+disorder.&rft.au=Math%2C+S+B%3BJanardhan+Reddy%2C+Y+C&rft.aulast=Math&rft.aufirst=S&rft.date=2007-07-01&rft.volume=61&rft.issue=7&rft.spage=1188&rft.isbn=&rft.btitle=&rft.title=International+journal+of+clinical+practice&rft.issn=13685031&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-18 N1 - Date created - 2007-06-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1. AN - 70616877; 17394548 AB - Several mutations have been found in the leucine-rich repeat kinase 2 gene (LRRK2), encoding the protein dardarin, which are associated with autosomal dominant Parkinson disease. We have previously shown that mutant LRRK2/dardarin is toxic to neurons and neuron-like cell lines in culture and that some mutations are also associated with an inclusion-body phenotype. There is a homologous kinase, LRRK1, which has a similar domain structure but is not known to carry mutations causing Parkinson disease. In the current study, we introduced mutations at equivalent residues in both LRRK2 and LRRK1 to determine their effects in cells. We show that mutations in dardarin are more prone to form inclusion bodies in transfected cells and are more toxic than equivalent mutations in LRRK1. This work suggests that dardarin/LRRK2 is inherently more damaging than LRRK1. JF - Journal of neurochemistry AU - Greggio, Elisa AU - Lewis, Patrick A AU - van der Brug, Marcel P AU - Ahmad, Rili AU - Kaganovich, Alice AU - Ding, Jinhui AU - Beilina, Alexandra AU - Baker, Acacia K AU - Cookson, Mark R AD - Cell Biology and Gene Expression Unit, National Institute on Aging, Bethesda, Maryland 20982-3707, USA. Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 93 EP - 102 VL - 102 IS - 1 SN - 0022-3042, 0022-3042 KW - Phosphoproteins KW - 0 KW - Guanosine Triphosphate KW - 86-01-1 KW - LRRK1 protein, human KW - EC 2.7.11.1 KW - LRRK2 protein, human KW - Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 KW - Protein-Serine-Threonine Kinases KW - Index Medicus KW - Microscopy, Confocal KW - Animals KW - Cytosol -- metabolism KW - COS Cells KW - Plasmids -- genetics KW - Humans KW - Immunoprecipitation KW - Reverse Transcriptase Polymerase Chain Reaction KW - Cloning, Molecular KW - Guanosine Triphosphate -- metabolism KW - Brain -- enzymology KW - Blotting, Western KW - Phosphorylation KW - Transfection KW - Mutation -- physiology KW - Cells, Cultured KW - Cercopithecus aethiops KW - Phosphoproteins -- metabolism KW - Protein-Serine-Threonine Kinases -- genetics KW - Protein-Serine-Threonine Kinases -- physiology KW - Parkinson Disease -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70616877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Mutations+in+LRRK2%2Fdardarin+associated+with+Parkinson+disease+are+more+toxic+than+equivalent+mutations+in+the+homologous+kinase+LRRK1.&rft.au=Greggio%2C+Elisa%3BLewis%2C+Patrick+A%3Bvan+der+Brug%2C+Marcel+P%3BAhmad%2C+Rili%3BKaganovich%2C+Alice%3BDing%2C+Jinhui%3BBeilina%2C+Alexandra%3BBaker%2C+Acacia+K%3BCookson%2C+Mark+R&rft.aulast=Greggio&rft.aufirst=Elisa&rft.date=2007-07-01&rft.volume=102&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-30 N1 - Date created - 2007-06-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Proteasome activity modulates chromatin modifications and RNA polymerase II phosphorylation to enhance glucocorticoid receptor-mediated transcription. AN - 70605176; 17438138 AB - The 26S proteasome modulates steroid hormone receptor-dependent gene transcription at least in part by regulating turnover and recycling of receptor/transcriptional DNA complexes, thereby ensuring continued hormone response. For the glucocorticoid receptor (GR), inhibition of proteasome-mediated proteolysis or RNA interference-mediated depletion of specific proteasome subunits results in an increase in gene expression. To facilitate transcription, proteasome inhibition alters at least two features associated with modification of chromatin architecture and gene transcription. First, proteasome inhibition increases trimethyl histone H3K4 levels with a corresponding accumulation of this modification on GR-regulated promoters in vivo. Secondly, global levels of phosphorylated RNA polymerase II (Pol II) increase, together with hormone-dependent association of the phosphorylated Pol II, with the promoter and the body of the activated gene. We propose that apart from modulating receptor turnover, the proteasome directly influences both the transcription machinery and chromatin structure, factors integral to nuclear receptor-regulated gene transcription. JF - Molecular and cellular biology AU - Kinyamu, H Karimi AU - Archer, Trevor K AD - Chromatin and Gene Expression Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, 111 Alexander Drive, P.O. Box 12233 (MD C4-01), Research Triangle Park, NC 27709, USA. Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 4891 EP - 4904 VL - 27 IS - 13 SN - 0270-7306, 0270-7306 KW - Histones KW - 0 KW - Leupeptins KW - Proteasome Inhibitors KW - Protein Subunits KW - Receptors, Glucocorticoid KW - Protein Methyltransferases KW - EC 2.1.1.- KW - histone methyltransferase KW - Histone-Lysine N-Methyltransferase KW - EC 2.1.1.43 KW - RNA Polymerase II KW - EC 2.7.7.- KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - benzyloxycarbonylleucyl-leucyl-leucine aldehyde KW - RF1P63GW3K KW - Index Medicus KW - Histone-Lysine N-Methyltransferase -- genetics KW - Humans KW - Cell Line, Tumor KW - Protein Subunits -- metabolism KW - Histone-Lysine N-Methyltransferase -- metabolism KW - Mammary Tumor Virus, Mouse -- genetics KW - Phosphorylation -- drug effects KW - Leupeptins -- pharmacology KW - Methylation -- drug effects KW - Models, Genetic KW - Promoter Regions, Genetic -- genetics KW - RNA Interference KW - Histones -- genetics KW - RNA Polymerase II -- metabolism KW - Transcription, Genetic -- drug effects KW - Proteasome Endopeptidase Complex -- metabolism KW - Chromatin Assembly and Disassembly -- genetics KW - Chromatin Assembly and Disassembly -- drug effects KW - Gene Expression Regulation -- drug effects KW - Receptors, Glucocorticoid -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70605176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Proteasome+activity+modulates+chromatin+modifications+and+RNA+polymerase+II+phosphorylation+to+enhance+glucocorticoid+receptor-mediated+transcription.&rft.au=Kinyamu%2C+H+Karimi%3BArcher%2C+Trevor+K&rft.aulast=Kinyamu&rft.aufirst=H&rft.date=2007-07-01&rft.volume=27&rft.issue=13&rft.spage=4891&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-09 N1 - Date created - 2007-06-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cell. 2006 Dec 29;127(7):1375-88 [17190601] J Biol Chem. 2005 Dec 23;280(51):41789-92 [16263726] Mol Cell. 2000 Jun;5(6):939-48 [10911988] Mol Cell. 2001 May;7(5):981-91 [11389845] J Biol Chem. 2001 Nov 16;276(46):42714-21 [11555652] Cell. 2002 Feb 22;108(4):501-12 [11909521] Science. 2002 Apr 19;296(5567):548-50 [11964484] Mol Cell Biol. 2002 Jun;22(12):4113-23 [12024025] J Biol Chem. 2002 Dec 13;277(50):48366-71 [12376534] Curr Biol. 2002 Dec 23;12(24):R855-7 [12498707] Mol Cell Biol. 2003 Mar;23(6):1922-34 [12612067] Mol Cell. 2003 Mar;11(3):695-707 [12667452] Mol Cell Biol. 2003 Jun;23(11):3763-73 [12748280] Mol Cell Biol. 2003 Aug;23(16):5867-81 [12897156] Nat Cell Biol. 2003 Oct;5(10):845-50 [14523392] Cell. 2003 Dec 12;115(6):751-63 [14675539] Nat Cell Biol. 2004 Jan;6(1):73-7 [14661024] Mol Cell. 2004 Jan 16;13(1):55-65 [14731394] Mol Cell. 2004 Feb 13;13(3):435-42 [14967150] Cell. 2004 Feb 20;116(4):511-26 [14980219] Mol Endocrinol. 2004 Mar;18(3):493-9 [14673136] Mol Cell Biol. 2004 Apr;24(7):2682-97 [15024059] Mol Cell Biol. 2004 Apr;24(8):3347-58 [15060156] Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5904-9 [15069196] Proc Natl Acad Sci U S A. 2004 May 11;101(19):7357-62 [15123803] Nat Cell Biol. 2004 Aug;6(8):731-40 [15235609] Genes Dev. 2004 Oct 15;18(20):2437-68 [15489290] Nature. 1995 Mar 2;374(6517):91-4 [7870181] Cell. 1995 Dec 15;83(6):835-9 [8521507] Cell. 1998 Feb 6;92(3):367-80 [9476896] Nature. 1998 May 7;393(6680):88-91 [9590696] Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):749-54 [15640349] Mol Cell. 2005 Mar 18;17(6):805-15 [15780937] J Mol Endocrinol. 2005 Apr;34(2):281-97 [15821097] J Steroid Biochem Mol Biol. 2005 Mar;94(4):337-46 [15857753] Cell. 2005 Jun 17;121(6):873-85 [15960975] Cell. 2005 Jun 17;121(6):913-23 [15960978] Nature. 2005 Aug 11;436(7052):876-80 [15988478] Cell Cycle. 2005 Jul;4(7):919-26 [15970672] Mol Cell Biol. 2005 Nov;25(21):9447-59 [16227595] Cell. 2005 Nov 4;123(3):361-3 [16269325] Cell. 2005 Nov 4;123(3):423-36 [16269334] Nature. 2005 Dec 22;438(7071):1181-5 [16372014] Genes Dev. 2006 Mar 1;20(5):601-12 [16510875] Curr Opin Genet Dev. 2006 Apr;16(2):197-202 [16503126] Mol Cell. 2006 Mar 17;21(6):861-71 [16543154] Endocr J. 2006 Apr;53(2):157-72 [16618973] Nature. 2006 Jul 6;442(7098):86-90 [16728976] J Biol Chem. 2006 Sep 15;281(37):27346-55 [16837462] Mol Cell Biol. 2006 Oct;26(19):7331-41 [16980632] EMBO J. 2006 Sep 20;25(18):4223-33 [16957778] Mol Cell. 2007 Feb 9;25(3):369-83 [17289585] Mol Endocrinol. 2007 Apr;21(4):843-56 [17227884] EMBO J. 1999 Nov 15;18(22):6439-47 [10562555] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Morphine, nortriptyline and their combination vs. placebo in patients with chronic lumbar root pain. AN - 70569688; 17182183 AB - Although lumbar radicular pain is the most common chronic neuropathic pain syndrome, there have been few randomized studies of drug treatments. We compared the efficacy of morphine (15-90 mg), nortriptyline (25-100 mg), their combination, and a benztropine "active placebo" (0.25-1 mg) in patients with chronic sciatica. Each period consisted of 5 weeks of dose escalation, 2 weeks of maintenance at the highest tolerated doses, and 2 weeks of dose tapering. The primary outcome was the mean daily leg pain score on a 0-10 scale during the maintenance period. Secondary outcomes included a 6-point ordinal global pain relief scale, the Beck Depression Inventory (BDI), the Oswestry Back Pain Disability Index (ODI) and the SF-36. In the 28 out of 61 patients who completed the study, none of the treatments produced significant reductions in average leg pain or other leg or back pain scores. Pain reduction, relative to placebo treatment was, 14% for nortriptyline (95% CI=[-2%, 30%]), 7% for morphine (95% CI=[-8%, 22%]), and 7% for the combination treatment (95% CI=[-4%, 18%]). Mean doses were: nortriptyline alone, 84+/-24.44 (SD) mg/day; morphine alone, 62+/-29 mg/day; and combination, morphine, 49+/-27 mg/day plus nortriptyline, 55 mg+/-33.18 mg/day. Over half of the study completers reported some adverse effect with morphine, nortriptyline or their combination. Within the limitations of the modest sample size and high dropout rate, these results suggest that nortriptyline, morphine and their combination may have limited effectiveness in the treatment of chronic sciatica. JF - Pain AU - Khoromi, Suzan AU - Cui, Lihong AU - Nackers, Lisa AU - Max, Mitchell B AD - Section on Developmental Genetic Epidemiology, National Institute of Mental Health, Department of Health and Human Services, Bethesda, MD 20892-3720, USA. khoromisu@mail.nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 66 EP - 75 VL - 130 IS - 1-2 KW - Analgesics, Opioid KW - 0 KW - Antidepressive Agents, Tricyclic KW - Placebos KW - Morphine KW - 76I7G6D29C KW - Nortriptyline KW - BL03SY4LXB KW - Index Medicus KW - Spinal Nerve Roots KW - Humans KW - Aged KW - Drug Therapy, Combination KW - Adult KW - Treatment Outcome KW - Cross-Over Studies KW - Chronic Disease KW - Middle Aged KW - Female KW - Male KW - Lumbar Vertebrae KW - Antidepressive Agents, Tricyclic -- administration & dosage KW - Sciatica -- drug therapy KW - Morphine -- adverse effects KW - Nortriptyline -- adverse effects KW - Antidepressive Agents, Tricyclic -- adverse effects KW - Analgesics, Opioid -- adverse effects KW - Analgesics, Opioid -- administration & dosage KW - Morphine -- administration & dosage KW - Nortriptyline -- administration & dosage KW - Radiculopathy -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70569688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pain&rft.atitle=Morphine%2C+nortriptyline+and+their+combination+vs.+placebo+in+patients+with+chronic+lumbar+root+pain.&rft.au=Khoromi%2C+Suzan%3BCui%2C+Lihong%3BNackers%2C+Lisa%3BMax%2C+Mitchell+B&rft.aulast=Khoromi&rft.aufirst=Suzan&rft.date=2007-07-01&rft.volume=130&rft.issue=1-2&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=Pain&rft.issn=1872-6623&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-27 N1 - Date created - 2007-06-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Curr Med Res Opin. 2006 Feb;22(2):375-84 [16466610] Pain. 2005 Dec 5;118(3):289-305 [16213659] J Rheumatol. 2000 Mar;27(3):772-8 [10743823] Spine (Phila Pa 1976). 2000 Dec 15;25(24):3130-9 [11124729] Spine (Phila Pa 1976). 2001 Mar 1;26(5):E93-E113 [11242399] Pain. 2001 Nov;94(2):149-58 [11690728] Anesthesiology. 2002 May;96(5):1053-61 [11981142] Neurology. 2002 Oct 8;59(7):1015-21 [12370455] Neurology. 2003 Mar 25;60(6):927-34 [12654955] N Engl J Med. 2003 Mar 27;348(13):1223-32 [12660386] Neurology. 2003 Apr 22;60(8):1274-83 [12707429] Neurology. 2003 Apr 22;60(8):1284-9 [12707430] Pain. 2003 Sep;105(1-2):71-8 [14499422] Arch Neurol. 2003 Nov;60(11):1524-34 [14623723] Am J Med. 2004 Sep 6;117 Suppl 5A:2S-7S [15478846] Br J Clin Pharmacol. 1979 Jul;8(1):7-20 [552299] Physiotherapy. 1980 Aug;66(8):271-3 [6450426] Neurology. 1982 Jun;32(6):671-3 [6283422] Pain. 1986 Oct;27(1):117-26 [3785962] J Chronic Dis. 1987;40(3):251-8 [3818881] Pain. 1988 Apr;33(1):11-23 [2454440] Neurology. 1988 Sep;38(9):1427-32 [3412591] Arthritis Rheum. 1990 Feb;33(2):160-72 [2306288] Clin Pharmacol Ther. 1990 Mar;47(3):305-12 [2178851] Neurology. 1991 Jul;41(7):1024-8 [1712433] N Engl J Med. 1992 May 7;326(19):1250-6 [1560801] Pain. 1993 Nov;55(2):259-66 [8309713] Lancet. 1996 Jan 20;347(8995):143-7 [8544547] Lancet. 1997 Mar 15;349(9054):753-8 [9074573] Neurology. 1998 Jun;50(6):1837-41 [9633737] Psychosomatics. 1998 May-Jun;39(3):263-72 [9664773] Pain. 1998 Jun;76(3):287-96 [9718247] Neurology. 1998 Oct;51(4):1166-71 [9781549] Pain. 1999 Dec;83(3):389-400 [10568846] J Pain Symptom Manage. 1998 Oct;16(4):220-9 [9803049] Neurology. 2004 Dec 14;63(11):2104-10 [15596757] N Engl J Med. 2005 Mar 31;352(13):1324-34 [15800228] J Pain. 2005 Apr;6(4):253-60 [15820913] JAMA. 2005 Jun 22;293(24):3043-52 [15972567] Expert Rev Neurother. 2005 Nov;5(6):823-30 [16274339] J Pain. 2005 Dec;6(12):829-36 [16326371] Anesthesiology. 2006 Jun;104(6):1283-92 [16732101] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Magnitude and impact of comorbidity of mental disorders from epidemiologic surveys. AN - 70563658; 17551350 AB - To consider comorbidity across multiple classes of disorders in data derived from recent large-scale community surveys. There has been substantial recent progress in our understanding of patterns and implications of comorbidity of mental disorders. There is now converging evidence on the magnitude and specific patterns of comorbidity in international studies worldwide. There is increasing recognition of comorbidity of mental and physical disorders. Comorbidity of mental disorders and substance abuse has now been recognized universally, and the results of treatment and prevention studies incorporating comorbidity are now beginning to emerge. Comorbidity has been shown to be an index of more severe course and outcome of mental disorders. Systematic inclusion of comorbidity into clinical evaluation and treatment will enhance the effectiveness of intervention with these conditions. Prevention of the development of secondary conditions as a consequence of primary disorders should reduce the impact of these conditions on both the individual and society. JF - Current opinion in psychiatry AU - Merikangas, Kathleen R AU - Kalaydjian, Amanda AD - National Institute of Mental Health, Bethesda, Maryland 20892, USA. kathleen.merikangas@nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 353 EP - 358 VL - 20 IS - 4 SN - 0951-7367, 0951-7367 KW - Index Medicus KW - Severity of Illness Index KW - Psychotherapy -- statistics & numerical data KW - Humans KW - Patient Acceptance of Health Care -- statistics & numerical data KW - Drug Therapy -- statistics & numerical data KW - Comorbidity KW - Depressive Disorder, Major -- diagnosis KW - Mood Disorders -- diagnosis KW - Anxiety Disorders -- diagnosis KW - Anxiety Disorders -- therapy KW - Depressive Disorder, Major -- epidemiology KW - Depressive Disorder, Major -- therapy KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- diagnosis KW - Surveys and Questionnaires KW - Mood Disorders -- therapy KW - Anxiety Disorders -- epidemiology KW - Mood Disorders -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70563658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+psychiatry&rft.atitle=Magnitude+and+impact+of+comorbidity+of+mental+disorders+from+epidemiologic+surveys.&rft.au=Merikangas%2C+Kathleen+R%3BKalaydjian%2C+Amanda&rft.aulast=Merikangas&rft.aufirst=Kathleen&rft.date=2007-07-01&rft.volume=20&rft.issue=4&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+psychiatry&rft.issn=09517367&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-05 N1 - Date created - 2007-06-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An adaptive approach for bivariate phase II clinical trial designs. AN - 70523213; 17303476 AB - In designing a phase II cancer clinical trial monitoring simultaneously the response and toxicity rate of a therapeutic agent, the odds ratio has to be specified. The false positive or Type I error rate, however, can be substantially inflated if the specified value is considerably larger than the true odds ratio. To overcome the sensitivity of the error rates to the odds ratio, an adaptive procedure is proposed which allows the sample size to be re-estimated based on observed odds ratio. Simulation results show that the procedure is robust against the odds ratio assumptions and controls effectively the Type I error rate. JF - Contemporary clinical trials AU - Wu, Chengqing AU - Liu, Aiyi AD - Biometry and Mathematical Statistics Branch, DESPR, National Institute of Child Health and Human Development, DHHS, 6100 Executive Boulevard, Rockville, MD 20852, USA. Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 482 EP - 486 VL - 28 IS - 4 SN - 1551-7144, 1551-7144 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Neoplasms -- drug therapy KW - Odds Ratio KW - Endpoint Determination KW - Humans KW - Antineoplastic Agents -- toxicity KW - Sample Size KW - Antineoplastic Agents -- therapeutic use KW - Clinical Trials, Phase II as Topic -- statistics & numerical data KW - Research Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70523213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contemporary+clinical+trials&rft.atitle=An+adaptive+approach+for+bivariate+phase+II+clinical+trial+designs.&rft.au=Wu%2C+Chengqing%3BLiu%2C+Aiyi&rft.aulast=Wu&rft.aufirst=Chengqing&rft.date=2007-07-01&rft.volume=28&rft.issue=4&rft.spage=482&rft.isbn=&rft.btitle=&rft.title=Contemporary+clinical+trials&rft.issn=15517144&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-17 N1 - Date created - 2007-05-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dopamine depresses immunity in the tiger shrimp Penaeus monodon. AN - 70440197; 17210259 AB - The total haemocyte count (THC), differential haemocyte count (DHC), phenoloxidase activity, respiratory bursts (release of superoxide anion), superoxide dismutase activity, phagocytic activity and clearance efficiency to the pathogen Photobacterium damsela were measured when tiger shrimp Penaeus monodon (13.5+/-1.5 g) were individually injected with saline or dopamine at 10(-8), 10(-7), or 10(-6)mol shrimp(-1). Results showed that a transient period of immunosuppression occurred between 2 and 8h after injection of dopamine for all immune parameters except circulating haemocytes, and all immune parameters had returned to control values within 8-16 h after receiving dopamine. The injection of dopamine also significantly increased the mortality of P. monodon challenged with the pathogen Pho. damsela. These results suggest that stress-inducing dopamine suppresses the immune system, which in turn promotes the susceptibility of P. monodon to Pho. damsela. JF - Fish & shellfish immunology AU - Chang, Chin-Chyuan AU - Wu, Zhi-Rong AU - Kuo, Ching-Ming AU - Cheng, Winton AD - Department of Tropical Agriculture and International Cooperation, National Pingtung University of Science and Technology, 1 Sheuh Fu Road, Nei Pu Hsiang, Pingtung County 91201, Taiwan, ROC. Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 24 EP - 33 VL - 23 IS - 1 SN - 1050-4648, 1050-4648 KW - Monophenol Monooxygenase KW - EC 1.14.18.1 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Respiratory Burst -- drug effects KW - Monophenol Monooxygenase -- metabolism KW - Animals KW - Superoxide Dismutase -- metabolism KW - Hemocytes -- drug effects KW - Phagocytosis -- drug effects KW - Photobacterium -- immunology KW - Immune Tolerance -- drug effects KW - Penaeidae -- immunology KW - Dopamine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70440197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fish+%26+shellfish+immunology&rft.atitle=Dopamine+depresses+immunity+in+the+tiger+shrimp+Penaeus+monodon.&rft.au=Chang%2C+Chin-Chyuan%3BWu%2C+Zhi-Rong%3BKuo%2C+Ching-Ming%3BCheng%2C+Winton&rft.aulast=Chang&rft.aufirst=Chin-Chyuan&rft.date=2007-07-01&rft.volume=23&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Fish+%26+shellfish+immunology&rft.issn=10504648&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-24 N1 - Date created - 2007-04-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - [Collaboration between occupational doctors in the public prevention services and qualified occupational doctors: description of an experience in the sandstone sector of Alto Mugello]. TT - Il rapporto tra medico del lavoro nei servizi pubblici di prevenzione e medico competente: descrizione di un'esperienza nel comparto lapideo dell'Alto Mugello. AN - 70142923; 18409759 AB - The present course of work-related injuries imposes an effective collaboration among public service's doctors and qualified occupational doctors. We refer to a positive interaction in a prevention plan of hand-arm vibrations exposure during phases of dressing in the sandstone sector of Alto Mugello. Both were acquired data on exposition (risk assessment, measures on tools, times and levels of exposition, etc.) and data on workers' health (an high number of workers showed suspect angioneurotic disorders). The symptomatic workers were subjected to a clinical-instrumental examination that highlighted a clear correlation between high hand-arm vibrations exposition and functional injury. Sharing informations is a precious tool both for Public Prevention Services, it enables in fact to realize an accurate representation of workers' health state, and for qualified occupational doctors to manage risk with employers and to carry out an effective health surveillance. JF - Giornale italiano di medicina del lavoro ed ergonomia AU - Faina, P L AU - Molinaro, F AU - Bolognesi, R AU - Pristerà, M AU - Mignani, G AD - UF Prevenzione, Igiene e Sicurezza nei Luoghi di Lavoro AUSL 10 Firenze, Toscana. PY - 2007 SP - 425 EP - 427 VL - 29 IS - 3 Suppl SN - 1592-7830, 1592-7830 KW - Index Medicus KW - Public Sector KW - Patient Care Team KW - Humans KW - Adult KW - Middle Aged KW - Italy KW - Hand-Arm Vibration Syndrome -- diagnosis KW - Hand-Arm Vibration Syndrome -- prevention & control KW - Occupational Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70142923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Giornale+italiano+di+medicina+del+lavoro+ed+ergonomia&rft.atitle=%5BCollaboration+between+occupational+doctors+in+the+public+prevention+services+and+qualified+occupational+doctors%3A+description+of+an+experience+in+the+sandstone+sector+of+Alto+Mugello%5D.&rft.au=Faina%2C+P+L%3BMolinaro%2C+F%3BBolognesi%2C+R%3BPrister%C3%A0%2C+M%3BMignani%2C+G&rft.aulast=Faina&rft.aufirst=P&rft.date=2007-07-01&rft.volume=29&rft.issue=3+Suppl&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Giornale+italiano+di+medicina+del+lavoro+ed+ergonomia&rft.issn=15927830&rft_id=info:doi/ LA - Italian DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-07-25 N1 - Date created - 2008-04-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - [Mesothelioma incidence decreases parallel to asbestos exposure decrement or interruption: a confirmation of a dose-response relationship, with implications in public health]. TT - L'incidenza del mesotelioma diminuisce parallelamente alla diminuzione o interruzione dell'esposizione ad amianto: una conferma della relazione dose-risposta, non priva di implicazioni preventive. AN - 69014490; 18050860 AB - On the basis of the available evidence, several groups of experts and investigators identified a dose-response relationship between exposure to commercial types of asbestos fibres and mesothelioma risk. The first mathematical model was proposed by Peto et al. It was derived from a conceptualisation of the multistage theory of cancer and provides an interpretation of the risk for the occurrence of mesothelioma in cohorts of exposed workers. In the study described in this paper, the author reviewed the data suggesting a decrease in mesotheliomas rate follosing reduction or interruption of exposure. Descriptive analyses and the few available long-term cohort studies indicate a decrease in risk. This is supported also by the fact that even the most biopersistent asbestos fibres are eliminated from the lungs. Indeed, a slow but effective reduction of risk has been demonstrated in the cohort of Wittenoom workers in Australia, previously exposed to crocidolite. JF - Epidemiologia e prevenzione AU - Merler, Enzo AD - Registro regionale veneto dei casi di mesotelioma, Servizio per la prevenzione e sicurezza nei luoghi di lavoro, AULSS 16, Padova. enzo.merler@sanita.padova.it PY - 2007 SP - 46 EP - 52 VL - 31 IS - 4 Suppl 1 SN - 1120-9763, 1120-9763 KW - Mineral Fibers KW - 0 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Biotransformation KW - Humans KW - Cohort Studies KW - Incidence KW - Models, Theoretical KW - Occupational Exposure -- statistics & numerical data KW - Mineral Fibers -- adverse effects KW - Mesothelioma -- epidemiology KW - Lung Neoplasms -- epidemiology KW - Asbestos -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69014490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiologia+e+prevenzione&rft.atitle=%5BMesothelioma+incidence+decreases+parallel+to+asbestos+exposure+decrement+or+interruption%3A+a+confirmation+of+a+dose-response+relationship%2C+with+implications+in+public+health%5D.&rft.au=Merler%2C+Enzo&rft.aulast=Merler&rft.aufirst=Enzo&rft.date=2007-07-01&rft.volume=31&rft.issue=4+Suppl+1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Epidemiologia+e+prevenzione&rft.issn=11209763&rft_id=info:doi/ LA - Italian DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-14 N1 - Date created - 2007-12-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Weekly epirubicin and paclitaxel with granulocyte colony-stimulating factor support in previously untreated metastatic breast cancer patients: a phase II study. AN - 68221267; 17762397 AB - We conducted a phase II study to determine the activity and tolerability of weekly epirubicin-paclitaxel and granulocyte colony-stimulating factor in breast cancer patients untreated for metastatic disease. The phase II study was designed following the Simon optimal-two stage method. Patients received epirubicin 25 mg/m and paclitaxel 80 mg/m every week, and granulocyte colony-stimulating factor on days 2 and 4 for 24 consecutive weeks in the absence of progression. From 1999 to 2004, 53 patients entered the study; 1093 weekly courses were delivered, with a median number of cycles of 22. Patients received a median relative dose intensity of 94%. No hematological grade 3-4 toxicities were observed. One patient had one episode of grade 3 mucositis and two patients (3.8%) suffered grade 2 asthenia. Eight patients (15.1%) experienced grade 2 neutropenia, grade 2 anemia was registered in seven patients (13.2%). No cardiotoxicity was observed. Ten out of 53 patients (18.9, 95% confidence interval 8.3, 29.4%) showed a complete response, whereas 28 (52.8, 95% confidence interval 39.4, 66.3%) had a partial response, with an overall response rate of 71.7% (95% confidence interval 59.6, 83.8%). In addition, 14 patients (26.4%) had stable disease. Median time to progression was 12 months (95% confidence interval 7, 17). Median response duration was 14 months (range 3-60). The 1-, 3- and 5-year survival rates were 90.1, 68.0 and 56.6%, respectively. In untreated metastatic breast cancer patients, the weekly administration of epirubicin and paclitaxel with granulocyte colony-stimulating factor support seems to be extremely tolerable and active, and deserves further investigation into a phase III trial. JF - Anti-cancer drugs AU - Nisticò, Cecilia AU - Bria, Emilio AU - Cuppone, Federica AU - Fornier, Monica AU - Sperduti, Isabella AU - Carpino, Armando AU - Pace, Andrea AU - Cognetti, Francesco AU - Terzoli, Edmondo AD - Department of Medical Oncology, Regina Elena National Cancer Institute, Roma, Italy. Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 687 EP - 692 VL - 18 IS - 6 SN - 0959-4973, 0959-4973 KW - Recombinant Proteins KW - 0 KW - Granulocyte Colony-Stimulating Factor KW - 143011-72-7 KW - Epirubicin KW - 3Z8479ZZ5X KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Paclitaxel -- administration & dosage KW - Disease-Free Survival KW - Drug Administration Schedule KW - Granulocyte Colony-Stimulating Factor -- therapeutic use KW - Humans KW - Disease Progression KW - Granulocyte Colony-Stimulating Factor -- adverse effects KW - Aged KW - Paclitaxel -- therapeutic use KW - Epirubicin -- adverse effects KW - Paclitaxel -- adverse effects KW - Epirubicin -- therapeutic use KW - Adult KW - Neoplasm Metastasis KW - Middle Aged KW - Granulocyte Colony-Stimulating Factor -- administration & dosage KW - Epirubicin -- administration & dosage KW - Adolescent KW - Female KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- mortality KW - Breast Neoplasms -- pathology KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68221267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anti-cancer+drugs&rft.atitle=Weekly+epirubicin+and+paclitaxel+with+granulocyte+colony-stimulating+factor+support+in+previously+untreated+metastatic+breast+cancer+patients%3A+a+phase+II+study.&rft.au=Nistic%C3%B2%2C+Cecilia%3BBria%2C+Emilio%3BCuppone%2C+Federica%3BFornier%2C+Monica%3BSperduti%2C+Isabella%3BCarpino%2C+Armando%3BPace%2C+Andrea%3BCognetti%2C+Francesco%3BTerzoli%2C+Edmondo&rft.aulast=Nistic%C3%B2&rft.aufirst=Cecilia&rft.date=2007-07-01&rft.volume=18&rft.issue=6&rft.spage=687&rft.isbn=&rft.btitle=&rft.title=Anti-cancer+drugs&rft.issn=09594973&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-27 N1 - Date created - 2007-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ginkgo biloba leave extract: biological, medicinal, and toxicological effects. AN - 68219468; 17763047 AB - Ginkgo biloba leave extract is among the most widely sold herbal dietary supplements in the United States. Its purported biological effects include: scavenging free radical; lowering oxidative stress; reducing neural damages, reducing platelets aggregation; anti-inflammation; anti-tumor activities; and anti-aging. Clinically, it has been prescribed to treat CNS disorders such as Alzheimer's disease and cognitive deficits. It exerts allergy and changes in bleeding time. While its mutagenicity or carcinogenic activity has not been reported, its components, quercetin, kaempferol and rutin have been shown to be genotoxic. There are no standards or guidelines regulating the constituent components of Ginkgo biloba leave extract nor are exposure limits imposed. Safety evaluation of Ginkgo biloba leave extract is being conducted by the U.S. National Toxicology Program. JF - Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews AU - Chan, Po-Chuen AU - Xia, Qingsu AU - Fu, Peter P AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. chanp@niehs.nih.gov PY - 2007 SP - 211 EP - 244 VL - 25 IS - 3 SN - 1059-0501, 1059-0501 KW - Antioxidants KW - 0 KW - Ginkgo biloba extract 501 KW - Neuroprotective Agents KW - Plant Extracts KW - Ginkgo biloba extract KW - 19FUJ2C58T KW - Index Medicus KW - Molecular Structure KW - Animals KW - Humans KW - Plant Leaves -- chemistry KW - Plant Extracts -- pharmacology KW - Ginkgo biloba -- toxicity KW - Antioxidants -- pharmacology KW - Plant Extracts -- therapeutic use KW - Antioxidants -- toxicity KW - Antioxidants -- therapeutic use KW - Plant Extracts -- toxicity KW - Neuroprotective Agents -- therapeutic use KW - Ginkgo biloba -- chemistry KW - Neuroprotective Agents -- toxicity KW - Neuroprotective Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68219468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+science+and+health.+Part+C%2C+Environmental+carcinogenesis+%26+ecotoxicology+reviews&rft.atitle=Ginkgo+biloba+leave+extract%3A+biological%2C+medicinal%2C+and+toxicological+effects.&rft.au=Chan%2C+Po-Chuen%3BXia%2C+Qingsu%3BFu%2C+Peter+P&rft.aulast=Chan&rft.aufirst=Po-Chuen&rft.date=2007-07-01&rft.volume=25&rft.issue=3&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+science+and+health.+Part+C%2C+Environmental+carcinogenesis+%26+ecotoxicology+reviews&rft.issn=10590501&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-18 N1 - Date created - 2007-08-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fatigue: implications for the elderly. AN - 68193375; 17714001 AB - Sporadic and chronic fatigue are common, but an underlying etiology is identified in only up to 10% of cases. Under-reporting makes fatigue's prevalence unknown. Some estimate up to 50% of elders suffer from mild fatigue. Causes vary, but prevailing theory links most fatigue as a secondary consequence to illness and medication. Fatigue is prominently linked to sleep disorders, depression, heart disease, Parkinson's disease, anemia, and cancer. Fatigue and its consequences should be assessed routinely. Empiric treatment is the norm, focusing on managing fatigue, and, when possible, selecting agents with fewer side effects. Exercise, diet, and promoting good sleep hygiene have beneficial effects in symptom management. JF - The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists AU - Wick, Jeannette Y AU - LaFleur, Joanne AD - National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 566 EP - 70, 573-4, 576-8 VL - 22 IS - 7 SN - 0888-5109, 0888-5109 KW - Index Medicus KW - Consultants KW - Professional Role KW - Risk Factors KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Aged KW - Pharmacists KW - Fatigue -- prevention & control KW - Geriatric Assessment -- methods KW - Fatigue -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68193375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Consultant+pharmacist+%3A+the+journal+of+the+American+Society+of+Consultant+Pharmacists&rft.atitle=Fatigue%3A+implications+for+the+elderly.&rft.au=Wick%2C+Jeannette+Y%3BLaFleur%2C+Joanne&rft.aulast=Wick&rft.aufirst=Jeannette&rft.date=2007-07-01&rft.volume=22&rft.issue=7&rft.spage=566&rft.isbn=&rft.btitle=&rft.title=The+Consultant+pharmacist+%3A+the+journal+of+the+American+Society+of+Consultant+Pharmacists&rft.issn=08885109&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-18 N1 - Date created - 2007-08-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - XRCC1 down-regulation in human cells leads to DNA-damaging agent hypersensitivity, elevated sister chromatid exchange, and reduced survival of BRCA2 mutant cells. AN - 68179493; 17603793 AB - Previous studies using rodent cells indicate that a deficiency in XRCC1 results in reduced single-strand break repair, increased sensitivity to DNA-damaging agents, and elevated levels of sister chromatid exchange (SCE). Epidemiological studies have suggested an association of certain human XRCC1 polymorphisms with genetic instability and cancer susceptibility. However, investigations on the molecular functions of XRCC1 in human cells are limited. To determine the contributions of this nonenzymatic scaffold protein, we suppressed XRCC1 levels in several human cell lines using small interfering RNA (siRNA) technology. We report that XRCC1 down-regulation in HeLa cells leads to a concomitant decrease in the DNA ligase 3 protein level and an impaired nick ligation capacity. In addition, depletion of XRCC1 resulted in a significantly increased sensitivity to the alkylating agent methyl methanesulfonate and the thymidine base analog 5-hydroxymethyl-2'-deoxyuridine, a slightly increased sensitivity to ethyl methanesulfonate and 1,3-bis(2-chloroethyl)-1-nitrosourea, and no change in the response to camptothecin. We also discovered that a 70-80% reduction in XRCC1 protein leads to an elevated level of SCE in both HeLa cells and normal human fibroblasts, but does not affect chromosome aberrations in the diploid fibroblasts. Last, XRCC1 siRNA transfection led to an approximately 40% decrease in the survival of BRCA2-deficient cells, supporting a model whereby the accumulation of unrepaired SSBs leads to the accumulation of cytotoxic DNA double strand breaks following replication fork collapse in cells defective in homologous recombination. (c) 2007 Wiley-Liss, Inc. JF - Environmental and molecular mutagenesis AU - Fan, Jinshui AU - Wilson, Paul F AU - Wong, Heng-Kuan AU - Urbin, Salustra S AU - Thompson, Larry H AU - Wilson, David M AD - Laboratory of Molecular Gerontology, National Institute on Aging, Baltimore, Maryland, USA. Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 491 EP - 500 VL - 48 IS - 6 SN - 0893-6692, 0893-6692 KW - BRCA2 Protein KW - 0 KW - Cell Extracts KW - DNA-Binding Proteins KW - Mutagens KW - RNA, Small Interfering KW - X-ray repair cross complementing protein 1 KW - Methyl Methanesulfonate KW - AT5C31J09G KW - Index Medicus KW - Animals KW - Cricetulus KW - HeLa Cells KW - Humans KW - RNA, Small Interfering -- metabolism KW - Methyl Methanesulfonate -- toxicity KW - Micronucleus Tests KW - Neoplasms -- pathology KW - Cell Survival -- drug effects KW - Transfection KW - CHO Cells KW - Chromosomal Instability -- drug effects KW - Cricetinae KW - Down-Regulation KW - DNA Damage KW - Sister Chromatid Exchange -- drug effects KW - DNA-Binding Proteins -- genetics KW - BRCA2 Protein -- metabolism KW - Mutation -- genetics KW - Mutagens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68179493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=XRCC1+down-regulation+in+human+cells+leads+to+DNA-damaging+agent+hypersensitivity%2C+elevated+sister+chromatid+exchange%2C+and+reduced+survival+of+BRCA2+mutant+cells.&rft.au=Fan%2C+Jinshui%3BWilson%2C+Paul+F%3BWong%2C+Heng-Kuan%3BUrbin%2C+Salustra+S%3BThompson%2C+Larry+H%3BWilson%2C+David+M&rft.aulast=Fan&rft.aufirst=Jinshui&rft.date=2007-07-01&rft.volume=48&rft.issue=6&rft.spage=491&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=08936692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-06 N1 - Date created - 2007-08-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Too many mutants with multiple mutations. AN - 68143843; 17687667 AB - It has recently become clear that the classical notion of the random nature of mutation does not hold for the distribution of mutations among genes: most collections of mutants contain more isolates with two or more mutations than predicted by the mutant frequency on the assumption of a random distribution of mutations. Excesses of multiples are seen in a wide range of organisms, including riboviruses, DNA viruses, prokaryotes, yeasts, and higher eukaryotic cell lines and tissues. In addition, such excesses are produced by DNA polymerases in vitro. These "multiples" appear to be generated by transient, localized hypermutation rather than by heritable mutator mutations. The components of multiples are sometimes scattered at random and sometimes display an excess of smaller distances between mutations. As yet, almost nothing is known about the mechanisms that generate multiples, but such mutations have the capacity to accelerate those evolutionary pathways that require multiple mutations where the individual mutations are neutral or deleterious. Examples that impinge on human health may include carcinogenesis and the adaptation of microbial pathogens as they move between individual hosts. JF - Critical reviews in biochemistry and molecular biology AU - Drake, John W AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709-2233, USA. drake@niehs.nih.gov PY - 2007 SP - 247 EP - 258 VL - 42 IS - 4 SN - 1040-9238, 1040-9238 KW - Index Medicus KW - Animals KW - Humans KW - Neoplasms -- genetics KW - Evolution, Molecular KW - Adaptation, Biological KW - Mutation -- genetics KW - Mutagenesis -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68143843?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+biochemistry+and+molecular+biology&rft.atitle=Too+many+mutants+with+multiple+mutations.&rft.au=Drake%2C+John+W&rft.aulast=Drake&rft.aufirst=John&rft.date=2007-07-01&rft.volume=42&rft.issue=4&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+biochemistry+and+molecular+biology&rft.issn=10409238&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-12 N1 - Date created - 2007-08-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1437-42 [11818556] Proc Natl Acad Sci U S A. 2007 May 15;104(20):8403-8 [17485671] J Virol. 2002 Jun;76(11):5822-8 [11992012] J Biol Chem. 2002 Sep 20;277(38):35550-60 [12121998] Genetics. 2002 Dec;162(4):1505-11 [12524327] Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):776-81 [12552134] J Virol. 2003 Mar;77(5):2946-55 [12584319] J Bacteriol. 2004 Aug;186(15):4846-52 [15262917] Mol Microbiol. 2004 Sep;53(5):1343-57 [15387814] Mutat Res. 2004 Oct 4;554(1-2):223-40 [15450421] Mutat Res. 1974 Dec;25(3):407-9 [4612357] J Biol Chem. 1985 May 10;260(9):5787-96 [3988773] J Mol Biol. 1986 May 20;189(2):273-84 [3018259] Proc Natl Acad Sci U S A. 1987 May;84(10):3354-8 [3554239] Proc Natl Acad Sci U S A. 1987 Sep;84(17):6220-4 [3306672] Proc Natl Acad Sci U S A. 1988 Nov;85(21):8126-30 [3054881] Mol Gen Genet. 1988 Nov;214(3):396-404 [3063945] Mutat Res. 1989 Mar-May;220(2-3):241-53 [2494446] J Biol Chem. 1989 Oct 5;264(28):16948-56 [2476448] J Mol Biol. 1989 Sep 20;209(2):195-204 [2685319] Mol Gen Genet. 1989 Nov;219(3):349-58 [2622450] J Bacteriol. 1990 Jun;172(6):3009-14 [2160935] Mutat Res. 1990 Aug;244(4):353-7 [2385250] Biochimie. 1991 Apr;73(4):411-21 [1911941] Genetics. 1991 Oct;129(2):317-26 [1660424] Genetics. 1991 Nov;129(3):957-62 [1752431] J Mol Biol. 1991 Dec 20;222(4):925-36 [1762158] Mutat Res. 1993 Aug;288(2):249-55 [7688084] Genetics. 1993 Aug;134(4):1031-8 [8375646] Environ Mol Mutagen. 1993;22(3):138-46 [8404873] Nucleic Acids Res. 1993 Nov 11;21(22):5212-20 [7504813] Mutat Res. 1994 Sep 1;309(2):147-63 [7520972] Genetics. 1994 Oct;138(2):263-70 [7828810] Environ Mol Mutagen. 1995;26(3):218-25 [7588647] J Bacteriol. 1996 Apr;178(8):2388-96 [8636043] Mol Gen Genet. 1996 Jul 19;251(5):503-8 [8709955] J Biol Chem. 1997 Mar 14;272(11):7345-51 [9054433] Environ Mol Mutagen. 1997;30(3):273-86 [9366905] Biochemistry. 1998 Feb 24;37(8):2111-9 [9485358] J Mol Biol. 1998 Apr 24;278(1):135-46 [9571039] Genetics. 1998 Apr;148(4):1655-65 [9560385] Mutagenesis. 1998 Sep;13(5):487-97 [9800194] J Biol Chem. 1999 Feb 5;274(6):3642-50 [9920913] J Bacteriol. 1999 Feb;181(4):1149-55 [9973340] Environ Mol Mutagen. 1999;33(2):132-43 [10217067] J Virol. 1999 Jul;73(7):5326-32 [10364279] J Mol Biol. 1964 Apr;8:610-3 [14153532] Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12849-54 [16118275] Mol Cell. 2005 Sep 16;19(6):791-804 [16168374] J Biol Chem. 2006 Feb 17;281(7):4486-94 [16344551] J Biol Chem. 2007 Jan 26;282(4):2324-32 [17121822] Genetics. 2007 May;176(1):697-702 [17194771] Bioessays. 2000 Apr;22(4):396-401 [10723037] Genetics. 2000 Apr;154(4):1427-37 [10747042] Science. 2000 Apr 21;288(5465):514-7 [10775110] Mutat Res. 2000 Sep 18;452(2):219-29 [11024481] J Biol Chem. 2001 Mar 30;276(13):10387-97 [11133987] Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7928-33 [11427720] Mol Gen Genet. 1992 Nov;235(2-3):173-8 [1465091] Mutagenesis. 1993 May;8(3):207-20 [8332083] J Virol. 2002 Apr;76(8):3605-14 [11907200] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chemoinformatic analysis of NCI preclinical tumor data: evaluating compound efficacy from mouse xenograft data, NCI-60 screening data, and compound descriptors. AN - 68103098; 17555311 AB - We provide a chemoinformatic examination of the NCI public human tumor xenograft data to explore relationships between small molecules, treatment modality, efficacy, and toxicity. Efficacy endpoints of tumor weight reduction (TW) and survival time increase (ST) compared to tumor bearing control mice were augmented by a toxicity measure, defined as the survival advantage of treated versus control animals (TX). These endpoints were used to define two independent therapeutic indices (TIs) as the ratio of efficacy (TW or ST) to toxicity (TX). Linear models predictive of xenograft endpoints were successfully constructed (0.67 < r(2) < or = 0.74)(observed_versus_predicted) using a model comprised of variables in treatment modality, chemoinformatic descriptors, and in vitro cell growth inhibition in the NCI 60-cell assay. Cross-validation analysis based on randomly chosen training subsets found these predictive correlations to be robust. Model-based sensitivity analysis found chemistry and growth inhibition to provide the best, and treatment modality the worst, indicators of xenograft endpoint. The poor predictive power derived from treatment alone appears to be of less importance to xenograft outcome for compounds having strongly similar chemical and biological features. ROC-based model validation found a 70% positive predictive value for distinguishing FDA approved oncology agents from available xenograft tested compounds. Additional chemoinformatic applications are provided that relate xenograft outcome to biological pathways and putative mechanism of compound action. These results find a strong relationship between xenograft efficacy and pathways comprised of genes having highly correlated mRNA expressions. Our analysis demonstrates that chemoinformatic studies utilizing a combination of xenograft data and in vitro preclinical testing offer an effective means to identify compound classes with superior efficacy and reduced toxicity. JF - Journal of chemical information and modeling AU - Wallqvist, Anders AU - Huang, Ruili AU - Covell, David G AD - Laboratory of Computational Technologies, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA. wallqvist@ncifcrf.gov PY - 2007 SP - 1414 EP - 1427 VL - 47 IS - 4 SN - 1549-9596, 1549-9596 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - United States KW - Drug Screening Assays, Antitumor KW - Animals KW - National Institutes of Health (U.S.) KW - Mice KW - Transplantation, Heterologous KW - Neoplasms, Experimental -- drug therapy KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68103098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chemical+information+and+modeling&rft.atitle=Chemoinformatic+analysis+of+NCI+preclinical+tumor+data%3A+evaluating+compound+efficacy+from+mouse+xenograft+data%2C+NCI-60+screening+data%2C+and+compound+descriptors.&rft.au=Wallqvist%2C+Anders%3BHuang%2C+Ruili%3BCovell%2C+David+G&rft.aulast=Wallqvist&rft.aufirst=Anders&rft.date=2007-07-01&rft.volume=47&rft.issue=4&rft.spage=1414&rft.isbn=&rft.btitle=&rft.title=Journal+of+chemical+information+and+modeling&rft.issn=15499596&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-01 N1 - Date created - 2007-07-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Conducting Internet-Based HIV/STD Prevention Survey Research: Considerations in Design and Evaluation AN - 61409825; 200802119 AB - The aim of this paper is to advance rigorous Internet-based HIV/STD Prevention quantitative research by providing guidance to fellow researchers, faculty supervising graduates, human subjects' committees, and review groups about some of the most common and challenging questions about Internet-based HIV prevention quantitative research. The authors represent several research groups who have gained experience conducting some of the first Internet-based HIV/STD prevention quantitative surveys in the US and elsewhere. Sixteen questions specific to Internet-based HIV prevention survey research are identified. To aid rigorous development and review of applications, these questions are organized around six common criteria used in federal review groups in the US: significance, innovation, approach (broken down further by research design, formative development, procedures, sampling considerations, and data collection); investigator, environment and human subjects' issues. Strategies promoting minority participant recruitment, minimizing attrition, validating participants, and compensating participants are discussed. Throughout, the implications on budget and realistic timetabling are identified. Adapted from the source document. JF - AIDS and Behavior AU - Pequegnat, Willo AU - Rosser, B. R. Simon AU - Bowen, Anne M AU - Bull, Sheana S AU - DiClemente, Ralph J AU - Bockting, Walter O AU - Elford, Jonathan AU - Fishbein, Martin AU - Gurak, Laura AU - Horvath, Keith AU - Konstan, Joseph AU - Noar, Seth M AU - Ross, Michael W AU - Sherr, Lorraine AU - Spiegel, David AU - Zimmerman, Rick AD - Center for Mental Health Research on AIDS, National Institute of Mental Health, Bethesda, MD, USA Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 505 EP - 521 PB - Springer, Dordrecht, The Netherlands VL - 11 IS - 4 SN - 1090-7165, 1090-7165 KW - Prevention KW - Minority Groups KW - Research Methodology KW - Acquired Immune Deficiency Syndrome KW - United States of America KW - Internet KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61409825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=Conducting+Internet-Based+HIV%2FSTD+Prevention+Survey+Research%3A+Considerations+in+Design+and+Evaluation&rft.au=Pequegnat%2C+Willo%3BRosser%2C+B.+R.+Simon%3BBowen%2C+Anne+M%3BBull%2C+Sheana+S%3BDiClemente%2C+Ralph+J%3BBockting%2C+Walter+O%3BElford%2C+Jonathan%3BFishbein%2C+Martin%3BGurak%2C+Laura%3BHorvath%2C+Keith%3BKonstan%2C+Joseph%3BNoar%2C+Seth+M%3BRoss%2C+Michael+W%3BSherr%2C+Lorraine%3BSpiegel%2C+David%3BZimmerman%2C+Rick&rft.aulast=Pequegnat&rft.aufirst=Willo&rft.date=2007-07-01&rft.volume=11&rft.issue=4&rft.spage=505&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-006-9172-9 LA - English DB - Social Services Abstracts N1 - Date revised - 2008-04-02 N1 - Number of references - 79 N1 - Last updated - 2016-09-28 N1 - CODEN - AIBEFC N1 - SubjectsTermNotLitGenreText - Acquired Immune Deficiency Syndrome; Prevention; Minority Groups; Internet; Research Methodology; United States of America DO - http://dx.doi.org/10.1007/s10461-006-9172-9 ER - TY - JOUR T1 - Russia and the Bologna Process. European by Education? TT - La Russie et le processus de Bologne. Europeenne par education? AN - 59772641; 200718730 AB - In 2003, Russia joined the Bologna process, which aims to create common European higher education space. This process, although not in the strict European Union framework, is an interface with Russia in educational matters, but also illustrates the contradictions of the relations between Europe and Russia. In this field as in others, Russia is torn between the awareness of sharing a common future with Europe and the attachment of its political elite to the them of "national specificity.". Adapted from the source document. JF - Politique etrangere AU - Kastoueva-Jean, Tatiana AD - Centre Russie/NEI Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 411 EP - 423 PB - Armand Colin, France IS - 2 SN - 0032-342X, 0032-342X KW - Political Elites KW - European Union KW - Educational Policy KW - Higher Education KW - Russia KW - Contradictions KW - article KW - 9065: international relations; international institutions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59772641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awpsa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Politique+etrangere&rft.atitle=Russia+and+the+Bologna+Process.+European+by+Education%3F&rft.au=Kastoueva-Jean%2C+Tatiana&rft.aulast=Kastoueva-Jean&rft.aufirst=Tatiana&rft.date=2007-07-01&rft.volume=&rft.issue=2&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=Politique+etrangere&rft.issn=0032342X&rft_id=info:doi/ LA - French DB - Worldwide Political Science Abstracts N1 - Date revised - 2007-11-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - European Union; Russia; Educational Policy; Higher Education; Contradictions; Political Elites ER - TY - JOUR T1 - Tobacco Control: Impact of National ABC Promotion on 1-800-QUIT-NOW AN - 58755695; 2007-24121 AB - Purpose. ABC's World News Tonight (WNT) promotion of 800-QUIT-NOW allowed for a nationwide introduction of the QUIT-NOW number, this study examined the impact on call volume. Design: Pre-postassessment. Setting: National health promotion campaign. Subjects: US. population (smokers). Measures: Monthly call attempts to the quitline at national and state levels. Intervention: During November 2005 ABC's WNT highlighted the National Network of Tobacco Cessation Quitlines' toll-free number, 800-QUIT-NOW, during the month-long series, 'Quit to Live: Fighting Lung Cancer.' Analysis: We compared changes in call volume prepromotion, during promotion, and postpromotion by percent and regional differences, range, and average number of calls. Results: Overall call volume in the United States (49 states and the District of Columbia) increased markedly in November, 37,049 calls compared with 16,145 in October. Although there was large variability across states, there was an average of 317 calls prepromotion, 726 calls during the promotion, and 397 calls postpromotion. Conclusion: The promotion highlighted the need for capacity building in terms of both sustained promotion and ability of quitlines to provide service as the number of calls increased, well as the importance of coordinating efforts so adjustments to individual state quitlines can be made. The series sewed as the first national promotion and drew attention to the potential impact on the National Network of Tobacco Cessation Quitlines. Adapted from the source document. JF - American Journal of Health Promotion AU - Hurd, Ami L AU - Augustson, Erik M AU - Backinger, Cathy L AU - Deaton, Candace AU - Bright, Mary Anne AD - Tobacco Control Research Branch, Behavioral Research Program, Division of Cancer Control & Population Sciences, National Cancer Institute/SAIC-Fredrick, Bethesda, MD Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 481 EP - 483 PB - AJHP Inc, West Bloomfield MI VL - 21 IS - 6 SN - 0890-1171, 0890-1171 KW - Social conditions and policy - Drinking, smoking, and drug addiction KW - Social conditions and policy - Psychology KW - Tobacco Cessation, Quitline, Promotion, Mass Media, Prevention Research. Format: research, Research purpose: intervention testing/program evaluation, Study design: quasi-experimental, Outcome measure: behavioral, Setting: state/national, Health focus: smoking control, Strategy: education, Target population: youth, adults, seniors, Target population circumstances: geographic location KW - Smoking - Prevention - Information sources KW - Telephone in counseling KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58755695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Health+Promotion&rft.atitle=Tobacco+Control%3A+Impact+of+National+ABC+Promotion+on+1-800-QUIT-NOW&rft.au=Hurd%2C+Ami+L%3BAugustson%2C+Erik+M%3BBackinger%2C+Cathy+L%3BDeaton%2C+Candace%3BBright%2C+Mary+Anne&rft.aulast=Hurd&rft.aufirst=Ami&rft.date=2007-07-01&rft.volume=21&rft.issue=6&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Health+Promotion&rft.issn=08901171&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2007-12-07 N1 - Last updated - 2016-09-28 N1 - CODEN - AJHPED N1 - SubjectsTermNotLitGenreText - Telephone in counseling; Smoking - Prevention - Information sources ER - TY - JOUR T1 - Comparability of Self-Collected Vaginal Swabs and Physician-Collected Cervical Swabs for Detection of Human Papillomavirus Infections in Rakai, Uganda AN - 57307737; 200926217 AB - Objective: The objective of this study was to compare human papillomavirus (HPV) DNA testing between self-administered vaginal swabs and physician-administered cervical swabs in women from rural Rakai District, Uganda. Study Design: Between 2002 and 2003, women from a population-based cohort participated in an HPV study. Women collected self-administered vaginal swabs and were also offered a pelvic examination, which included physician-collected cervical samples. Methods: Hybrid-capture 2 was used to determine carcinogenic HPV status. Polymerase chain reaction was used to determine HPV genotypes. Unweighted K statistics were used to determine agreement. Results: Compliance with self-collected swabs was > 86%; however, only 51% accepted a pelvic examination. Carcinogenic HPV prevalence was 19% in self-collected and 19% in physician-collected samples. Agreement among paired observations was 92% with a K of 0.75. Kappa between self- and physician-collected samples was similar in HIV strata (K = 0.71 and 0.75 for HIV-positive and HIV-negative, respectively). Discussion: In this community-based setting, detection of carcinogenic HPV was comparable among self- and physician-administered samples. Self-collection is a feasible and accurate means of obtaining HPV samples from women in resource-poor settings or persons reluctant to undergo a pelvic examination. Adapted from the source document. JF - Sexually Transmitted Diseases AU - Safaeian, Mahboobeh AU - Kiddugavu, Mohammed AU - Gravitt, Patti E AU - Ssekasanvu, Joseph AU - Murokora, Dan AU - Sklar, Marc AU - Serwadda, David AU - Wawer, Maria J AU - Shah, Keerti V AU - Gray, Ron AD - National Cancer Instit, Bethesda, MD safaeianm@mail.nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 429 EP - 436 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 34 IS - 7 SN - 0148-5717, 0148-5717 KW - Pelvic examination KW - Detection KW - Women KW - Uganda KW - HIV KW - Human papillomaviruses KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57307737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexually+Transmitted+Diseases&rft.atitle=Comparability+of+Self-Collected+Vaginal+Swabs+and+Physician-Collected+Cervical+Swabs+for+Detection+of+Human+Papillomavirus+Infections+in+Rakai%2C+Uganda&rft.au=Safaeian%2C+Mahboobeh%3BKiddugavu%2C+Mohammed%3BGravitt%2C+Patti+E%3BSsekasanvu%2C+Joseph%3BMurokora%2C+Dan%3BSklar%2C+Marc%3BSerwadda%2C+David%3BWawer%2C+Maria+J%3BShah%2C+Keerti+V%3BGray%2C+Ron&rft.aulast=Safaeian&rft.aufirst=Mahboobeh&rft.date=2007-07-01&rft.volume=34&rft.issue=7&rft.spage=429&rft.isbn=&rft.btitle=&rft.title=Sexually+Transmitted+Diseases&rft.issn=01485717&rft_id=info:doi/10.1097%2F01.olq.0000243623.67673.22 L2 - http://www.stdjournal.com LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-10-02 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Human papillomaviruses; Women; Pelvic examination; HIV; Uganda; Detection DO - http://dx.doi.org/10.1097/01.olq.0000243623.67673.22 ER - TY - JOUR T1 - Atypical Lexical/Semantic Processing in High-Functioning Autism Spectrum Disorders without Early Language Delay AN - 57254493; 200816192 AB - Although autism is associated with impaired language functions, the nature of semantic processing in high-functioning pervasive developmental disorders (HFPDD) without a history of early language delay has been debated. In this study, we aimed to examine whether the automatic lexical/semantic aspect of language is impaired or intact in these population. Eleven individuals with Asperger's Disorder (AS) or HFPDD-Not Otherwise Specified (NOS) and age-, IQ-, and gender-matched typically developing individuals performed a semantic decision task in four conditions using an indirect priming paradigm. Semantic priming effects were found for near-semantically related word pairs in the controls, whereas this was not the case in the AS or HFPDDNOS participants. This finding suggests similarities in the underlying semantic processing of language across PDD subtypes. Adapted from the source document. JF - Journal of Autism and Developmental Disorders AU - Kamio, Yoko AU - Robins, Diana AU - Kelley, Elizabeth AU - Swainson, Brook AU - Fein, Deborah AD - Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, 187-8553 Tokyo, Japan kamio@ncnp.go.np Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 1116 EP - 1122 PB - Springer, Dordrecht The Netherlands VL - 37 IS - 6 SN - 0162-3257, 0162-3257 KW - High functioning KW - Priming KW - Pervasive developmental disorders KW - Language disorders KW - Asperger's syndrome KW - Semantic processing KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57254493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Atypical+Lexical%2FSemantic+Processing+in+High-Functioning+Autism+Spectrum+Disorders+without+Early+Language+Delay&rft.au=Kamio%2C+Yoko%3BRobins%2C+Diana%3BKelley%2C+Elizabeth%3BSwainson%2C+Brook%3BFein%2C+Deborah&rft.aulast=Kamio&rft.aufirst=Yoko&rft.date=2007-07-01&rft.volume=37&rft.issue=6&rft.spage=1116&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/10.1007%2Fs10803-006-0254-3 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-08-04 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDDQ N1 - SubjectsTermNotLitGenreText - High functioning; Asperger's syndrome; Language disorders; Pervasive developmental disorders; Priming; Semantic processing DO - http://dx.doi.org/10.1007/s10803-006-0254-3 ER - TY - JOUR T1 - The Influence of Prayer Coping on Mental Health among Cardiac Surgery Patients AN - 57221381; 200803524 AB - To address the inconsistent findings and based on Hegel's dialectic contradictive principle, this study tested a parallel mediation model that may underlie the association of using prayer for coping with cardiac surgery outcomes. Three sequential interviews were conducted with 310 patients who underwent open-heart surgery. A structural equation model demonstrated that optimism mediated the favorable effect of prayer coping. Prayer coping was also related to preoperative stress symptoms, which had a counterbalance effect on outcomes. Age was associated with better preoperative mental health, but age-related chronic conditions were associated with poor outcomes; both of these were mediated through the same mediators. [Copyright 2007 Sage Publications Ltd.] JF - Journal of Health Psychology AU - Ai, Amy L AU - Peterson, Christopher AU - Tice, Terrence N AU - Huang, Bu AU - Rodgers, Willard AU - Bolling, Steven F AD - University of Washington/University of Michigan, USA moserr@mail.nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 580 EP - 596 PB - Sage Publications, London UK VL - 12 IS - 4 SN - 1359-1053, 1359-1053 KW - Coping strategies KW - Cardiac surgery KW - Prayers KW - Preoperative coping KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57221381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Psychology&rft.atitle=The+Influence+of+Prayer+Coping+on+Mental+Health+among+Cardiac+Surgery+Patients&rft.au=Ai%2C+Amy+L%3BPeterson%2C+Christopher%3BTice%2C+Terrence+N%3BHuang%2C+Bu%3BRodgers%2C+Willard%3BBolling%2C+Steven+F&rft.aulast=Ai&rft.aufirst=Amy&rft.date=2007-07-01&rft.volume=12&rft.issue=4&rft.spage=580&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Psychology&rft.issn=13591053&rft_id=info:doi/10.1177%2F1359105307078164 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-03-04 N1 - Last updated - 2016-09-27 N1 - CODEN - JHPSFC N1 - SubjectsTermNotLitGenreText - Coping strategies; Prayers; Cardiac surgery; Preoperative coping DO - http://dx.doi.org/10.1177/1359105307078164 ER - TY - JOUR T1 - Reallocating resources: how should the National Institute for Health and Clinical Excellence guide disinvestment efforts in the National Health Service? AN - 57220771; 200809383 AB - The recent acute budgetary pressures within the English National Health Service (NHS) have accentuated calls for targeted disinvestment thereby eliminating ineffective or low-value services to provide resources that can be reallocated toward more cost-effective purposes. This challenge extends beyond allocating new resources wisely, a goal that has been, since its inception, the primary focus of the National institute for Health and Clinical Excellence (NICE). But on 6 September 2006, the Department of Health announced a new mandate for NICE to help the NHS identify interventions that are not effective. This paper discusses current NICE efforts to support value in the NHS and then explores the policy options available to the Institute as it prepares to launch a programme to meet the NHS request for guidance on disinvestment. All of the possible options present challenges. NICE will need to collaborate in new ways with partners inside, and perhaps outside, the NHS. However, the Institute has an established reputation for rigour, transparency and political durability that makes it well qualified to sustain public support in the face of difficult decisions. Disinvestment will provide a stern test of these qualities. Adapted from the source document. JF - Journal of Health Services Research & Policy AU - Pearson, Steven AU - Littlejohns, Peter AD - Department of Clinical Bioethics, National Institutes of Health, 10 Center Drive, MSC 1156, Bethesda, MD 20892-1156, USA spearson99@yahoo.com Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 160 EP - 165 PB - Royal Society of Medicine Press Ltd, London UK VL - 12 IS - 3 SN - 1355-8196, 1355-8196 KW - Cost containment KW - Resource allocation KW - Financial restraints KW - Cost effectiveness KW - Budgets KW - National health services KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57220771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Services+Research+%26+Policy&rft.atitle=Reallocating+resources%3A+how+should+the+National+Institute+for+Health+and+Clinical+Excellence+guide+disinvestment+efforts+in+the+National+Health+Service%3F&rft.au=Pearson%2C+Steven%3BLittlejohns%2C+Peter&rft.aulast=Pearson&rft.aufirst=Steven&rft.date=2007-07-01&rft.volume=12&rft.issue=3&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Services+Research+%26+Policy&rft.issn=13558196&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-05-02 N1 - Last updated - 2016-09-27 N1 - CODEN - JHRPFD N1 - SubjectsTermNotLitGenreText - National health services; Budgets; Financial restraints; Cost effectiveness; Resource allocation; Cost containment ER - TY - JOUR T1 - Metabolic disease and cardiovascular risk in people treated with antipsychotics in the community AN - 57107995; 200802527 AB - Background Prevalence of physical comorbidity in severe mental illness is a significant public health concern, but comparative data in people with diagnoses other than schizophrenia are sparse. Aims To investigate the prevalence of metabolic disease and cardiovascular risk in people with severe mental illness treated with antipsychotics in the community. Methods Case-control study of 90 people treated with antipsychotics in the community and 92 age- and gender-matched controls. The prevalence of metabolic syndrome and 10-year cardiovascular risk were calculated. Results People on antipsychotics had a significantly worse metabolic profile than controls (F=6.583, d.f.=15,161, P<0.000l). Moreover, metabolic syndrome was more prevalent (OR=3.68, 95% Cl 1.71-7.93, P=0.001), as was cardiovascular risk across a number of outcomes. These results are consistent across diagnostic groups. Conclusions People with severe mental illness treated with antipsychotics have excess metabolic dysfunction and heightened risk for cardiovascular disease. Declaration of Interest P.M., I.N.F. and P.G. have received honoraria for educational meetings from pharmaceutical companies. Funding detailed in Acknowledgements. Adapted from the source document. JF - The British Journal of Psychiatry AU - Mackin, Paul AU - Bishop, David AU - Watkinson, Helen AU - Gallagher, Peter AU - Ferrier, I Nicol AD - School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Leazes Wing (Psychiatry), Royal Victoria Infirmary, Newcastle upon Tyne NEI 4LP, UK paul.mackin@ncl.ac.uk Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 23 EP - 29 PB - Royal College of Psychiatrists, London UK VL - 191 SN - 0007-1250, 0007-1250 KW - Mentally ill people KW - Antipsychotic drugs KW - Metabolic diseases KW - Comorbidity KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57107995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+Journal+of+Psychiatry&rft.atitle=Metabolic+disease+and+cardiovascular+risk+in+people+treated+with+antipsychotics+in+the+community&rft.au=Mackin%2C+Paul%3BBishop%2C+David%3BWatkinson%2C+Helen%3BGallagher%2C+Peter%3BFerrier%2C+I+Nicol&rft.aulast=Mackin&rft.aufirst=Paul&rft.date=2007-07-01&rft.volume=191&rft.issue=&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=The+British+Journal+of+Psychiatry&rft.issn=00071250&rft_id=info:doi/10.1192%2Fbjp.bp.106.031716 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-02-04 N1 - Last updated - 2016-09-27 N1 - CODEN - BJPYAJ N1 - SubjectsTermNotLitGenreText - Mentally ill people; Antipsychotic drugs; Comorbidity; Metabolic diseases DO - http://dx.doi.org/10.1192/bjp.bp.106.031716 ER - TY - JOUR T1 - The epidemiology of DSM-IV specific phobia in the USA: results from the National Epidemiologic Survey on Alcohol and Related Conditions AN - 57105499; 200803213 AB - Background: There is a lack of current detailed national data on the prevalence, correlates, disability and co-morbidity of DSM-IV specific phobia (SP), the prevalence of specific objects and situations feared, and associations between impairment, treatment and co-morbidity and the number of specific situations and objects feared, among adults in the USA. Method: The data were derived from a large (43093) representative sample of the adult population in the USA. Results: Prevalences of 12-month and lifetime DSM-IV SP were 7.1% and 9.4% respectively. Being female, young, and low income increased risk, while being Asian or Hispanic decreased risk (p <0.05). The mean age at onset of SP was 9.7 years, the mean duration of episode was 20.1 years and only 8.0 % reported treatment specifically for SP. Most specific phobias involved multiple fears, and an increasing number of fears, regardless of content, was associated with greater disability and impairment, treatment seeking and co-morbidity with other Axis I and II disorders. Conclusions: SP is a highly prevalent, disabling and co-morbid disorder in the US adult population. The early onset of SP and the disorders most strongly associated with it highlights the need for longitudinal studies beginning in early childhood. Results suggest the existence of a generalized subtype of SP much like social phobia, which, once revealed, may lead to a classification of SP that is more etiologically and therapeutically meaningful. Adapted from the source document. JF - Psychological Medicine AU - Stinson, Frederick S AU - Dawson, Deborah A AU - Chou, S Patricia AU - Smith, Sharon AU - Goldstein, Rise B AU - Ruan, W June AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Room 3077, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, M.S. 9304, 5635 Fishers Lane, Bethesda, MD 20892-9304, USA Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 1047 EP - 1059 PB - Cambridge University Press, UK VL - 37 IS - 7 SN - 0033-2917, 0033-2917 KW - Diagnostic and Statistical Manual IV KW - USA KW - Phobias KW - Epidemiology KW - Comorbidity KW - Prevalence KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57105499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=The+epidemiology+of+DSM-IV+specific+phobia+in+the+USA%3A+results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions&rft.au=Stinson%2C+Frederick+S%3BDawson%2C+Deborah+A%3BChou%2C+S+Patricia%3BSmith%2C+Sharon%3BGoldstein%2C+Rise+B%3BRuan%2C+W+June%3BGrant%2C+Bridget+F&rft.aulast=Stinson&rft.aufirst=Frederick&rft.date=2007-07-01&rft.volume=37&rft.issue=7&rft.spage=1047&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS0033291707000086 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-02-04 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMDCO N1 - SubjectsTermNotLitGenreText - USA; Epidemiology; Diagnostic and Statistical Manual IV; Phobias; Prevalence; Comorbidity DO - http://dx.doi.org/10.1017/S0033291707000086 ER - TY - JOUR T1 - Anxiety-related biases in children's avoidant responses to a masked angry face AN - 57060220; 200719162 AB - While anxious children often show escape and withdrawal behaviours towards threats, few studies have experimentally assessed avoidance. The present study examined whether children with high levels of anxiety showed more avoidant responses to a neutral conditioned cue (CS+) that was paired with an unconditioned threat stimulus (UCS), a masked angry facial expression. Thirty-six 10 and 11 year-olds participated in a task, which involved choosing between two CS card stimuli of different colours to win points. Whilst both cards awarded the same number of points, one colour was systematically paired with a masked angry face (CS+), whilst the other colour was paired with a masked neutral face (CS-). Children with higher anxiety scores had an overall tendency to choose the card associated with the neutral face, with some evidence suggesting that this tendency emerged gradually across trials. These results suggest a relationship between anxiety and stimulus-response learning for CS+-UCS associations that support behavioural avoidance. [Copyright 2006 Elsevier Ltd.] JF - Behaviour Research and Therapy AU - Lau, Jennifer Y F AU - Viding, Essi M AD - MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, UK lauj@mail.nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 1639 EP - 1645 PB - Elsevier, Amsterdam The Netherlands VL - 45 IS - 7 SN - 0005-7967, 0005-7967 KW - Anxiety KW - Avoidance KW - Children KW - Facial expressions KW - Fear conditioning KW - Conditioning KW - Fear KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57060220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behaviour+Research+and+Therapy&rft.atitle=Anxiety-related+biases+in+children%27s+avoidant+responses+to+a+masked+angry+face&rft.au=Lau%2C+Jennifer+Y+F%3BViding%2C+Essi+M&rft.aulast=Lau&rft.aufirst=Jennifer+Y&rft.date=2007-07-01&rft.volume=45&rft.issue=7&rft.spage=1639&rft.isbn=&rft.btitle=&rft.title=Behaviour+Research+and+Therapy&rft.issn=00057967&rft_id=info:doi/10.1016%2Fj.brat.2006.08.006 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-11-01 N1 - Last updated - 2016-09-27 N1 - CODEN - BRTHAA N1 - SubjectsTermNotLitGenreText - Children; Anxiety; Fear; Facial expressions; Conditioning DO - http://dx.doi.org/10.1016/j.brat.2006.08.006 ER - TY - JOUR T1 - Cyto-nuclear genomic dissociation and the African elephant species question AN - 50486005; 2009-027285 AB - Studies of skull morphology and of nuclear DNA have strongly concluded that African elephants comprise two species. Nonetheless, a recent article [Debruyne (2005). A case study of apparent conflict between molecular phylogenies: the interrelationships of African elephants. Cladistics 21, 31-50] has suggested a single-species model for Loxodonta based on the polyphyly of a single genetic locus, mitochondrial DNA (mtDNA). Discordant patterns between mitochondrial and nuclear DNA markers were subsequently reported in some African savanna elephant populations, further supporting a two-species model, and prompting us to re-examine here the geographic distribution of different elephant morphotypes and their relationship to nuclear and mtDNA phylogeographic patterns. We used exact tests to compare the distribution of forest elephant-typical and savanna elephant-typical characteristics across eight published datasets containing morphological, mtDNA or nuclear DNA data for African elephants. Among the elephants examined by Debruyne (2005), we found that patterns of forest vs. savanna characteristics were significantly different (p<10 (super -5) ) between mtDNA and morphology, suggesting the presence of cyto-nuclear genomic dissociation. We show that the eight African elephant continent-wide datasets compared, including that of Debruyne (2005), together support a two-species model with cyto-nuclear genomic dissociation rather than a one-species model, and together indicate that Africa harbors two species of elephant. JF - Quaternary International AU - Roca, Alfred L AU - Georgiadis, Nicholas AU - O'Brien, Stephen J A2 - Agenbroad, Larry D. A2 - Haynes, Gary A2 - Johnson, Eileen A2 - Palombo, Maria Rita Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 4 EP - 16 PB - Elsevier, Oxford VL - 169-170 SN - 1040-6182, 1040-6182 KW - forests KW - Chordata KW - Loxodonta KW - Mammalia KW - Proboscidea KW - biogeography KW - genome KW - genetics KW - Elephantoidea KW - Theria KW - skull KW - bones KW - DNA KW - Elephantidae KW - Africa KW - savannas KW - Vertebrata KW - Eutheria KW - Tetrapoda KW - 11:Vertebrate paleontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50486005?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Quaternary+International&rft.atitle=Cyto-nuclear+genomic+dissociation+and+the+African+elephant+species+question&rft.au=Roca%2C+Alfred+L%3BGeorgiadis%2C+Nicholas%3BO%27Brien%2C+Stephen+J&rft.aulast=Roca&rft.aufirst=Alfred&rft.date=2007-07-01&rft.volume=169-170&rft.issue=&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Quaternary+International&rft.issn=10406182&rft_id=info:doi/10.1016%2Fj.quaint.2006.08.008 L2 - http://www.sciencedirect.com/science/journal/10406182 LA - English DB - GeoRef N1 - Conference title - Second world of elephants congress N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2009-01-01 N1 - Number of references - 26 N1 - Document feature - illus. incl. 1 table, sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - Africa; biogeography; bones; Chordata; DNA; Elephantidae; Elephantoidea; Eutheria; forests; genetics; genome; Loxodonta; Mammalia; Proboscidea; savannas; skull; Tetrapoda; Theria; Vertebrata DO - http://dx.doi.org/10.1016/j.quaint.2006.08.008 ER - TY - CPAPER T1 - Dosage of Histone H3 and Centromeric Histone H3 Variant Cse4P Affect Chromosome Transmission Fidelity in S. Cerevisiae. T2 - XXIIIrd International Conference on Yeast Genetics and Molecular Biology AN - 39521987; 4664194 JF - XXIIIrd International Conference on Yeast Genetics and Molecular Biology AU - Basrai, Munira AU - Au, Wei-Chun AU - DeLuca, Steve AU - Crisp, Matthew AU - Rando, Oliver Y1 - 2007/07/01/ PY - 2007 DA - 2007 Jul 01 KW - Chromosomes KW - Histone H3 KW - Fidelity KW - Histones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39521987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXIIIrd+International+Conference+on+Yeast+Genetics+and+Molecular+Biology&rft.atitle=Dosage+of+Histone+H3+and+Centromeric+Histone+H3+Variant+Cse4P+Affect+Chromosome+Transmission+Fidelity+in+S.+Cerevisiae.&rft.au=Basrai%2C+Munira%3BAu%2C+Wei-Chun%3BDeLuca%2C+Steve%3BCrisp%2C+Matthew%3BRando%2C+Oliver&rft.aulast=Basrai&rft.aufirst=Munira&rft.date=2007-07-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXIIIrd+International+Conference+on+Yeast+Genetics+and+Molecular+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.yeastgenome.org/community/meetings/yeast07/Melbourne_conten ts.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Quality of life among people with epilepsy: implication for psychosocial intervention AN - 37212409; 3906010 AB - Epilepsy is a stigmatising disorder. The available evidence suggests that its diagnosis can have important psychosocial consequences. Hence, it can severely affect the quality of everyday life of people with epilepsy and their families. The present study examines the psychosocial functioning and the quality of life in a group of people whose seizures were well controlled and in a group of people in whom seizures were not controlled. More number of people with epilepsy were worried about their seizure attacks. Among people with refractory epilepsy, psychosocial functioning and adjustment to epilepsy appeared to be low. Majority of people with refractory epilepsy reported high level of distress and more memory problems, problems in attention and concentration, and language problems. Reprinted with the permission of the TATA Institute of Social Sciences, India JF - Indian journal of social work AU - Janardhan, N AU - Johnson, John AU - Parthasarathy, R AD - Basic Needs India ; National Institute of Mental Health and Neuro Sciences Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 369 EP - 379 VL - 68 IS - 3 SN - 0019-5634, 0019-5634 KW - Sociology KW - Memory KW - Mental stress KW - Epilepsy KW - Social work KW - Quality of life UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/37212409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+journal+of+social+work&rft.atitle=Quality+of+life+among+people+with+epilepsy%3A+implication+for+psychosocial+intervention&rft.au=Janardhan%2C+N%3BJohnson%2C+John%3BParthasarathy%2C+R&rft.aulast=Janardhan&rft.aufirst=N&rft.date=2007-07-01&rft.volume=68&rft.issue=3&rft.spage=369&rft.isbn=&rft.btitle=&rft.title=Indian+journal+of+social+work&rft.issn=00195634&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 10525 12162 3898; 4361 3617 6220; 7953 7954; 7930; 11950 ER - TY - JOUR T1 - Young children's references to temporal attributes of allegedly experienced events in the course of forensic interviews AN - 36711779; 3442689 AB - Developmental differences in references to temporal attributes of allegedly experienced events were examined in 250 forensic interviews of 4- to 10-year-old alleged victims of sexual abuse. Children's ages, the specific temporal attributes referenced, and the types of memory tapped by the interviewers' questions significantly affected the quantity and quality of temporal references produced. The findings documented age-related increases in 4- to 10- year-olds' references to temporal attributes, using the appropriate relational terminology, both spontaneously and in response to temporal requests. More references to temporal attributes were elicited from recall than from recognition memory, highlighting spontaneous reporting capabilities. Implications for theories concerning the developing understanding of temporal concepts and for the design of effective, age-appropriate, forensic interview techniques are discussed. Reprinted by permission of the University of Chicago Press. © All rights reserved JF - Child development AU - Orbach, Yael AU - Lamb, Michael E AD - National Institute of Child Health and Human Development ; University of Cambridge Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 1100 EP - 1120 VL - 78 IS - 4 SN - 0009-3920, 0009-3920 KW - Sociology KW - Memory KW - Time KW - Sexual abuse KW - Forensic psychiatry KW - Parent-child relations KW - Interviews KW - Developmental psychology KW - Child welfare KW - Family studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36711779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+development&rft.atitle=Young+children%27s+references+to+temporal+attributes+of+allegedly+experienced+events+in+the+course+of+forensic+interviews&rft.au=Orbach%2C+Yael%3BLamb%2C+Michael+E&rft.aulast=Orbach&rft.aufirst=Yael&rft.date=2007-07-01&rft.volume=78&rft.issue=4&rft.spage=1100&rft.isbn=&rft.btitle=&rft.title=Child+development&rft.issn=00093920&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4783; 12756; 3518 10404; 5225 10391; 7930; 11559 11540 3015 11881; 9178 4777 6093 6823; 2208 2212; 6832 10919 ER - TY - JOUR T1 - Family rearing antecedents of pubertal timing AN - 36704703; 3442701 AB - Two general evolutionary hypotheses were tested on 756 White children (397 girls) studied longitudinally: (1) rearing experiences would predict pubertal timing; and (2) children would prove differentially susceptible to rearing. Analysis of pubertal measurements, including some based on repeated physical assessments, showed that mothering and fathering, earlier and later in childhood, predicted pubertal development, but only for girls, with negative parenting appearing most influential; maternal harsh control predicted earlier menarche. Rearing effects varied by infant negative emotionality, proving stronger (and opposite) for girls who in infancy were lower rather than higher in negativity. Maternal menarche, controlled in all analyses, was a stronger predictor than rearing. Findings are discussed in terms of theory development, genetic and nutritional influences, and sample restrictions. Reprinted by permission of the University of Chicago Press. © All rights reserved JF - Child development AU - Belsky, Jay AU - Steinberg, Laurence D AU - Houts, Renate M AU - Friedman, Sarah L AU - DeHart, Ganie AU - Cauffman, Elizabeth AU - Roisman, Glenn I AU - Halpern-Felsher, Bonnie L AU - Susman, Elisabeth AD - Birkbeck College ; Temple University ; RTI International ; CNA Corporation ; State University of New York, Genesco ; University of California, Irvine ; University of Illinois, Urbana-Champaign ; University of California, San Francisco ; Pennsylvania State University Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 1302 EP - 1321 VL - 78 IS - 4 SN - 0009-3920, 0009-3920 KW - Anthropology KW - Sociology KW - Sexuality KW - Adolescence KW - Parent-child relations KW - Empirical research KW - Maturity KW - Child development KW - Puberty KW - Family studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36704703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+development&rft.atitle=Family+rearing+antecedents+of+pubertal+timing&rft.au=Belsky%2C+Jay%3BSteinberg%2C+Laurence+D%3BHouts%2C+Renate+M%3BFriedman%2C+Sarah+L%3BDeHart%2C+Ganie%3BCauffman%2C+Elizabeth%3BRoisman%2C+Glenn+I%3BHalpern-Felsher%2C+Bonnie+L%3BSusman%2C+Elisabeth&rft.aulast=Belsky&rft.aufirst=Jay&rft.date=2007-07-01&rft.volume=78&rft.issue=4&rft.spage=1302&rft.isbn=&rft.btitle=&rft.title=Child+development&rft.issn=00093920&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4783; 2197 2212 6075 3483; 10419 655; 590 652 5676 646 6091; 7834 646; 11579 11538; 4200 10902; 9178 4777 6093 6823 ER - TY - JOUR T1 - Chronological age, cognitions, and practices in European American mothers: a multivariate study of parenting AN - 36696641; 3437800 AB - The authors studied multiple parenting cognitions and practices in European American mothers (N = 262) who ranged from 15 to 47 years of age. All were 1st-time parents of 20-month-old children. Some age effects were 0; others were linear or nonlinear. Nonlinear age effects determined by spline regression showed significant associations to a 'knot' age ( ~30 years), with little or no association afterward. For parenting cognitions and practices that are age-sensitive, a 2-phase model of parental development is proposed. The findings stress the importance of considering maternal chronological age as a factor in developmental study. Reprinted by permission of the American Psychological Association JF - Developmental psychology AU - Bornstein, Marc H AU - Putnick, Diane L AD - National Institute of Child Health and Human Development, Bethesda Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 850 EP - 864 VL - 43 IS - 4 SN - 0012-1649, 0012-1649 KW - Sociology KW - Birth KW - Age KW - Development studies KW - Multivariate analysis KW - Parenting KW - Mothers KW - Europe KW - U.S.A. KW - Cognition KW - Pregnancy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36696641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+psychology&rft.atitle=Chronological+age%2C+cognitions%2C+and+practices+in+European+American+mothers%3A+a+multivariate+study+of+parenting&rft.au=Bornstein%2C+Marc+H%3BPutnick%2C+Diane+L&rft.aulast=Bornstein&rft.aufirst=Marc&rft.date=2007-07-01&rft.volume=43&rft.issue=4&rft.spage=850&rft.isbn=&rft.btitle=&rft.title=Developmental+psychology&rft.issn=00121649&rft_id=info:doi/10.1037%2F0012-1649.43.4.850 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 9183; 8379 12224 971; 646; 2449 10404; 8317 9184; 10020; 1635 11574; 3513; 129; 433 293 14 DO - http://dx.doi.org/10.1037/0012-1649.43.4.850 ER - TY - JOUR T1 - Romantic relationships among immigrant adolescents AN - 36679571; 3433324 AB - We examine the importance of the family and friendship group as two crucial developmental contexts for adolescent relationship experiences. We focus particularly on immigrant adolescents who make up an increasing proportion of the youth population and who come from cultural contexts with stronger family traditions than native-born adolescents. Using data from the National Longitudinal Study of Adolescent Health, we model the characteristics associated with having romantic relationships and participating in sex-related activities within relationships for immigrant adolescents, children of immigrants and adolescents in native-born families. First generation adolescents are less likely to enter romantic relationships than adolescents in native-born families, but those who do participate engage in similar sex-related activities as native-born youth. This evidence suggests that immigrant youth who enter romantic relationships are selective of the more assimilated to native adolescent norms of heterosexual behavior. The peer group is especially important for immigrant adolescents because it provides opportunities for romantic relationship involvement. JF - International migration review AU - King, Rosalind Berkowitz AU - Harris, Kathleen Mullan AD - National Institute of Child Health and Human Development ; University of Carolina, Chapel Hill Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 344 EP - 370 VL - 41 IS - 2 SN - 0197-9183, 0197-9183 KW - Sociology KW - Sexual behaviour KW - Cultural contact KW - Peer groups KW - Immigrants KW - Social environment KW - Interpersonal relations KW - Data analysis KW - Adolescents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36679571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+migration+review&rft.atitle=Romantic+relationships+among+immigrant+adolescents&rft.au=King%2C+Rosalind+Berkowitz%3BHarris%2C+Kathleen+Mullan&rft.aulast=King&rft.aufirst=Rosalind&rft.date=2007-07-01&rft.volume=41&rft.issue=2&rft.spage=344&rft.isbn=&rft.btitle=&rft.title=International+migration+review&rft.issn=01979183&rft_id=info:doi/10.1111%2Fj.1747-7379.2007.00071.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 6232 8037; 593; 11829 6077 4309; 6823; 3111; 11563 1025 1542 11325 6071; 9347; 3279 971 3286 DO - http://dx.doi.org/10.1111/j.1747-7379.2007.00071.x ER - TY - JOUR T1 - The National Institute of Child Health and Human Development Maternal-Fetal Medicine Unit Network Randomized Clinical Trial in Progress: Standard therapy versus no therapy for mild gestational diabetes AN - 223039041; 17596471 AB - It is recognized that women with gestational diabetes mellitus (GDM) who have significantly elevated fasting blood glucose levels are at increased risk for fetal macrosomia and perinatal morbidity if treatment is not provided (1,2). Nearly 15 years ago, an international consensus conference on the adverse effects of gestational diabetes co-sponsored by the National Institute of Child Health and Human Development and the National Institute of Diabetes and Digestive and Kidney Disease concluded that "the sensitivity, specificity, and cost-effectiveness of efforts to diagnosis and treat gestational diabetes mellitus in order to prevent adverse perinatal effects cannot be resolved without additional carefully designed studies" (14). JF - Diabetes Care AU - Landon, Mark B AU - Thom, Elizabeth AU - Spong, Catherine Y AU - Carpenter, Marshall AU - et al Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - S194 EP - 9 CY - Alexandria PB - American Diabetes Association VL - 30 SN - 01495992 KW - Medical Sciences--Endocrinology KW - Blood Glucose KW - Pregnancy KW - Mortality KW - Hyperglycemia KW - Birth weight KW - Womens health KW - Intensive care KW - Conferences KW - Diabetes KW - United States KW - Glucose Tolerance Test KW - Blood Glucose -- metabolism KW - Humans KW - National Institutes of Health (U.S.) KW - Fetal Development KW - Body Mass Index KW - Weight Gain KW - Obesity -- epidemiology KW - Diabetes, Gestational -- blood KW - Female KW - Diabetes, Gestational -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/223039041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes+Care&rft.atitle=The+National+Institute+of+Child+Health+and+Human+Development+Maternal-Fetal+Medicine+Unit+Network+Randomized+Clinical+Trial+in+Progress%3A+Standard+therapy+versus+no+therapy+for+mild+gestational+diabetes&rft.au=Landon%2C+Mark+B%3BThom%2C+Elizabeth%3BSpong%2C+Catherine+Y%3BCarpenter%2C+Marshall%3Bet+al&rft.aulast=Landon&rft.aufirst=Mark&rft.date=2007-07-01&rft.volume=30&rft.issue=&rft.spage=S194&rft.isbn=&rft.btitle=&rft.title=Diabetes+Care&rft.issn=01495992&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Diabetes Association Jul 2007 N1 - Document feature - Tables; References; Diagrams N1 - Last updated - 2013-02-10 N1 - CODEN - DICAD2 ER - TY - JOUR T1 - The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases AN - 218873046; 17538633 AB - The intestinal flora has long been thought to play a role either in initiating or in exacerbating the inflammatory bowel diseases (IBD). Host defenses, such as those mediated by the Toll-like receptors (TLR), are critical to the host/pathogen interaction and have been implicated in IBD pathophysiology. To explore the association of genetic variation in TLR pathways with susceptibility to IBD, we performed a replication study and pooled analyses of the putative IBD risk alleles in NFKB1 and TLR4, and we performed a haplotype-based screen for association to IBD in the TLR genes and a selection of their adaptor and signaling molecules. Our genotyping of 1539 cases of IBD and pooled analysis of 4805 cases of IBD validates the published association of a TLR4 allele with risk of IBD (odds ratio (OR): 1.30, 95% confidence interval (CI): 1.15-1.48; P=0.00017) and Crohn's disease (OR: 1.33, 95% CI: 1.16-1.54; P=0.000035) but not ulcerative colitis. We also describe novel suggestive evidence that TIRAP (OR: 1.16, 95% CI: 1.04-1.30; P=0.007) has a modest effect on risk of IBD. Our analysis, therefore, offers additional evidence that the TLR4 pathway - in this case, TLR4 and its signaling molecule TIRAP - plays a role in susceptibility to IBD. JF - Genes and Immunity AU - De Jager, P L AU - Franchimont, D AU - Waliszewska, A AU - Bitton, A AU - Cohen, A AU - Langelier, D AU - Belaiche, J AU - Vermeire, S AU - Farwell, L AU - Goris, A AU - Libioulle, C AU - Jani, N AU - Dassopoulos, T AU - Bromfield, G P AU - Dubois, B AU - Cho, J H AU - Brant, S R AU - Duerr, R H AU - Yang, H AU - Rotter, J I AU - Silverberg, M S Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 387 EP - 97 CY - Hamilton PB - Nature Publishing Group VL - 8 IS - 5 SN - 14664879 KW - Biology--Genetics KW - Membrane Glycoproteins KW - Receptors, Interleukin-1 KW - TIRAP protein, human KW - TLR4 protein, human KW - Toll-Like Receptor 4 KW - Toll-Like Receptors KW - Gene Frequency KW - Humans KW - Longitudinal Studies KW - Toll-Like Receptors -- metabolism KW - Genotype KW - Toll-Like Receptor 4 -- immunology KW - Haplotypes KW - Toll-Like Receptors -- genetics KW - Toll-Like Receptor 4 -- metabolism KW - Receptors, Interleukin-1 -- metabolism KW - Inflammatory Bowel Diseases -- immunology KW - Female KW - Male KW - Signal Transduction KW - Membrane Glycoproteins -- metabolism KW - Polymorphism, Single Nucleotide KW - Toll-Like Receptor 4 -- genetics KW - Receptors, Interleukin-1 -- genetics KW - Genetic Predisposition to Disease KW - Membrane Glycoproteins -- genetics KW - Inflammatory Bowel Diseases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/218873046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genes+and+Immunity&rft.atitle=The+role+of+the+Toll+receptor+pathway+in+susceptibility+to+inflammatory+bowel+diseases&rft.au=De+Jager%2C+P+L%3BFranchimont%2C+D%3BWaliszewska%2C+A%3BBitton%2C+A%3BCohen%2C+A%3BLangelier%2C+D%3BBelaiche%2C+J%3BVermeire%2C+S%3BFarwell%2C+L%3BGoris%2C+A%3BLibioulle%2C+C%3BJani%2C+N%3BDassopoulos%2C+T%3BBromfield%2C+G+P%3BDubois%2C+B%3BCho%2C+J+H%3BBrant%2C+S+R%3BDuerr%2C+R+H%3BYang%2C+H%3BRotter%2C+J+I%3BSilverberg%2C+M+S&rft.aulast=De+Jager&rft.aufirst=P&rft.date=2007-07-01&rft.volume=8&rft.issue=5&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Genes+and+Immunity&rft.issn=14664879&rft_id=info:doi/10.1038%2Fsj.gene.6364398 LA - English DB - ProQuest Central N1 - Copyright - Copyright Nature Publishing Group Jul 2007 N1 - Last updated - 2014-04-10 DO - http://dx.doi.org/10.1038/sj.gene.6364398 ER - TY - JOUR T1 - Old Drug, New Tricks: The Unexpected Effect of Doxazosin on High-Density Lipoprotein AN - 21245730; 7529553 JF - Circulation Research AU - Remaley, Alan T AD - National Institutes of Health, National Heart, Lung, and Blood Institute, Vascular Medicine Branch, Lipoprotein Metabolism Section Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 116 EP - 118 PB - Lippincott Williams & Wilkins, Inc, 530 Walnut Street Philadelphia PA 19106-3621 USA, [URL:http://www.lww.com/] VL - 101 IS - 2 SN - 0009-7330, 0009-7330 KW - Biotechnology and Bioengineering Abstracts KW - Lipoproteins KW - Drugs KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21245730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulation+Research&rft.atitle=Old+Drug%2C+New+Tricks%3A+The+Unexpected+Effect+of+Doxazosin+on+High-Density+Lipoprotein&rft.au=Remaley%2C+Alan+T&rft.aulast=Remaley&rft.aufirst=Alan&rft.date=2007-07-01&rft.volume=101&rft.issue=2&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Circulation+Research&rft.issn=00097330&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Lipoproteins; Drugs ER - TY - JOUR T1 - Intermediate Maple Syrup Urine Disease: Neuroimaging Observations in 3 Patients From South India AN - 21209576; 11650316 AB - Maple syrup urine disease is a disorder of branched-chain keto acid metabolism. Three children were diagnosed with the intermediate form of maple syrup urine disease during routine evaluation of mental retardation. Clinical features were characterized by mental retardation, seizures, autistic features, and movement disorder in the form of dystonia. High-performance liquid chromatography of the urine and serum revealed elevated levels of branched-chain amino acids, suggesting a diagnosis of maple syrup urine disease. Magnetic resonance imaging showed diffuse hyperintense signals in the white matter along with involvement of the thalami and globus pallidus. Magnetic resonance imaging in the intermediate form showed myelination in the posterior limb of the internal capsule, in contrast to the classic form of the disease. Knowledge about the neuroimaging findings of this rare disease will help to narrow down the differential diagnosis when evaluating children with unexplained mental retardation and seizures. JF - Journal of Child Neurology AU - Bindu, P S AU - Shehanaz, KE AU - Christopher, Rita AU - Pal, Pramod K AU - Ravishankar, S AD - department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 911 EP - 913 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 22 IS - 7 SN - 0883-0738, 0883-0738 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - maple syrup urine disease KW - branched chain amino acids KW - High-performance liquid chromatography KW - Neuroimaging KW - Amino acids KW - Seizures KW - Magnetic resonance imaging KW - Dystonia KW - Substantia alba KW - Children KW - Movement disorders KW - Limbs KW - Differential diagnosis KW - Urine KW - Globus pallidus KW - Mental retardation KW - Maple syrup urine disease KW - Myelination KW - Autism KW - Metabolism KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21209576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+Neurology&rft.atitle=Intermediate+Maple+Syrup+Urine+Disease%3A+Neuroimaging+Observations+in+3+Patients+From+South+India&rft.au=Bindu%2C+P+S%3BShehanaz%2C+KE%3BChristopher%2C+Rita%3BPal%2C+Pramod+K%3BRavishankar%2C+S&rft.aulast=Bindu&rft.aufirst=P&rft.date=2007-07-01&rft.volume=22&rft.issue=7&rft.spage=911&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+Neurology&rft.issn=08830738&rft_id=info:doi/10.1177%2F0883073807304003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Neuroimaging; Amino acids; Magnetic resonance imaging; Seizures; Substantia alba; Dystonia; Children; Differential diagnosis; Limbs; Movement disorders; Urine; Globus pallidus; Mental retardation; Myelination; Maple syrup urine disease; Autism; Metabolism DO - http://dx.doi.org/10.1177/0883073807304003 ER - TY - JOUR T1 - National Institute of Allergy and Infectious Diseases Bioinformatics Resource Centers: New Assets for Pathogen Informatics AN - 20998522; 7462113 JF - Infection and Immunity AU - Greene, John M AU - Collins, Frank AU - Lefkowitz, Elliot J AU - Roos, David AU - Scheuermann, Richard H AU - Sobral, Bruno AU - Stevens, Rick AU - White, Owen AU - Di Francesco, Valentina AD - SRA International, Inc., Health Research Systems, Rockville, Maryland 20852. University of Notre Dame, Department of Biological Sciences, Notre Dame, Indiana 46556. University of Alabama at Birmingham, Department of Microbiology, Birmingham, Alabama 35294-2170. University of Pennsylvania, Penn Genomics Institute, Philadelphia, Pennsylvania 19104-6018. University of Texas Southwestern Medical Center, Department of Pathology, Dallas, Texas 75390-9072. Virginia Bioinformatics Institute, Blacksburg, Virginia 24061. University of Chicago, Department of Computer Science, Chicago, Illinois 60637. The Institute for Genomic Research, Rockville, Maryland 20850. Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 3212 EP - 3219 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 7 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Hypersensitivity KW - Infectious diseases KW - Bioinformatics KW - Pathogens KW - F 06910:Microorganisms & Parasites KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20998522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=National+Institute+of+Allergy+and+Infectious+Diseases+Bioinformatics+Resource+Centers%3A+New+Assets+for+Pathogen+Informatics&rft.au=Greene%2C+John+M%3BCollins%2C+Frank%3BLefkowitz%2C+Elliot+J%3BRoos%2C+David%3BScheuermann%2C+Richard+H%3BSobral%2C+Bruno%3BStevens%2C+Rick%3BWhite%2C+Owen%3BDi+Francesco%2C+Valentina&rft.aulast=Greene&rft.aufirst=John&rft.date=2007-07-01&rft.volume=75&rft.issue=7&rft.spage=3212&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Pathogens; Hypersensitivity; Infectious diseases; Bioinformatics ER - TY - JOUR T1 - Phase-sensitive cardiac tagging-REALTAG AN - 20859276; 8368521 AB - Fully inverting spins, instead of merely saturating them, provides superior contrast for tagging procedures. The resulting improvement in tag contrast-to-noise ratio (CNR) yields higher-precision tag detection. Also, thinner slices and hence reduced tag separations can be employed, providing displacement and strain measurements with better spatial resolution. Alternatively, the improved tag contrast can be used to obtain cine images covering a greater portion of the cardiac cycle. The use of standard magnitude reconstruction for images of these inversion tags causes rectification of the negative-valued signals from the tags, confounding the image interpretation. Therefore, a phase-sensitive reconstruction scheme of the inverted tags must be employed. Here we demonstrate the implementation of inverted tags with phase-sensitive reconstruction in a ramped-flip-angle, steady-state free precession (SSFP) sequence. Magn Reson Med 58:206-210, 2007. JF - Magnetic Resonance in Medicine AU - Derbyshire, J Andrew AU - Sampath, Smita AU - McVeigh, Elliot R AD - Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland, USA, emcveigh@nih.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 206 EP - 210 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 58 IS - 1 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Inversion KW - Image processing KW - spatial discrimination KW - N.M.R. KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20859276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Phase-sensitive+cardiac+tagging-REALTAG&rft.au=Derbyshire%2C+J+Andrew%3BSampath%2C+Smita%3BMcVeigh%2C+Elliot+R&rft.aulast=Derbyshire&rft.aufirst=J&rft.date=2007-07-01&rft.volume=58&rft.issue=1&rft.spage=206&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21264 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Heart; N.M.R.; Image processing; Inversion; spatial discrimination DO - http://dx.doi.org/10.1002/mrm.21264 ER - TY - JOUR T1 - Correction of frequency and phase variations induced by eddy currents in localized spectroscopy with multiple echo times AN - 20857760; 8368516 AB - As a consequence of the time-varying magnetic field induced by eddy currents, frequency drifting occurs when the sampling window of localized spectroscopy continuously shifts. The frequency drifting and the concomitant phase variations can severely affect spectroscopy results when data are acquired with multiple echo times (TEs), such as in the measurement of glutamate (Glu) concentration using the TE-averaged method. Specifically, the averaged spectra are further broadened and distorted in the presence of residual eddy currents, and editing of the coupled spins of Glu C4 protons is affected, resulting in errors in the measured relative intensity ratio. Postacquisition correction using unsuppressed water as reference can effectively minimize this detrimental effect, as manifested by the significantly enhanced signal intensity. Also, it is demonstrated that the methyl signals of creatine (Cr) at 3.0 ppm and choline (Cho) at 3.2 ppm can be used as internal references in finding frequency and phase disparities between different TEs. Magn Reson Med 58:174-178, 2007. JF - Magnetic Resonance in Medicine AU - Zhang, Yan AU - Marenco, Stefano AU - Shen, Jun AD - National Institute of Mental Health, Bethesda, Maryland, USA, shenj@intra.nimh.nih.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 174 EP - 178 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 58 IS - 1 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Magnetic fields KW - Choline KW - Data processing KW - Phase variations KW - Protons KW - Creatine KW - N.M.R. KW - Glutamic acid KW - Sampling KW - Spectroscopy KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20857760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Correction+of+frequency+and+phase+variations+induced+by+eddy+currents+in+localized+spectroscopy+with+multiple+echo+times&rft.au=Zhang%2C+Yan%3BMarenco%2C+Stefano%3BShen%2C+Jun&rft.aulast=Zhang&rft.aufirst=Yan&rft.date=2007-07-01&rft.volume=58&rft.issue=1&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21265 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Spectroscopy; Phase variations; Creatine; Magnetic fields; Sampling; Glutamic acid; Protons; Data processing; N.M.R.; Choline DO - http://dx.doi.org/10.1002/mrm.21265 ER - TY - JOUR T1 - Measurement of spin-lattice relaxation times and chemical exchange rates in multiple-site systems using progressive saturation AN - 20857711; 8368498 AB - A new method for measuring spin-lattice relaxation times and chemical exchange (CE) rate constants in multiple-site exchanging systems is described. The method, chemical exchange and T1 measurement using progressive saturation (CUPS), was applied to determine T1s and analyze phosphorus exchange among phosphocreatine (PCr), ATP, and inorganic phosphate (Pi), mediated by creatine kinase (CK) and ATP synthase, using 31P-MRS. Two-site exchange was analyzed in vitro and in the rat leg, and three-site exchange was analyzed in the rat heart. Data were fitted to a model of progressive saturation incorporating T1 relaxation and CE. For the in vitro system at 8.45T, we found T1(PCr) = 2.86 s and T1(-ATP) = 1.72 s. For the rat gastrocnemius at 1.9T, we found T1(PCr) = 6.60 s and T1(-ATP) = 2.06 s. For the rat heart at 9.4T, we found T1(PCr) = 3.35 s, T1(-ATP) = 0.69 s, and T1(Pi) = 1.83 s. All of these values were within 20% of literature values. Similarly, the determined exchange rates were in the same range as published values. Using simulations, we compared CUPS with transient saturation transfer as a method for measuring T1s and rates. The two methods showed similar sensitivity to noise. We conclude that CUPS is a viable alternative for measuring T1s and CE rates in exchanging systems. Magn Reson Med 58:8-18, 2007. JF - Magnetic Resonance in Medicine AU - Galban, Craig J AU - Spencer, Richard G AD - NMR Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA, spencer@helix.nih.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 8 EP - 18 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 58 IS - 1 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Leg KW - Heart KW - Creatine kinase KW - Data processing KW - Phosphate KW - Phosphocreatine KW - Phosphorus KW - ATP synthase KW - ATP KW - N.M.R. KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20857711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Measurement+of+spin-lattice+relaxation+times+and+chemical+exchange+rates+in+multiple-site+systems+using+progressive+saturation&rft.au=Galban%2C+Craig+J%3BSpencer%2C+Richard+G&rft.aulast=Galban&rft.aufirst=Craig&rft.date=2007-07-01&rft.volume=58&rft.issue=1&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21185 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Heart; Data processing; N.M.R.; Phosphocreatine; ATP; ATP synthase; Phosphorus; Leg; Phosphate; Creatine kinase DO - http://dx.doi.org/10.1002/mrm.21185 ER - TY - JOUR T1 - Erratum to Kellman P, McVeigh ER. Image reconstruction in SNR units: a general method for SNR measurement. Magn Reson Med. 2005; 54:1439-1447. AN - 20827138; 8368928 AB - Abstract not available. JF - Magnetic Resonance in Medicine AU - Kellman, Peter Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 211 EP - 212 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 58 IS - 1 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20827138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Erratum+to+Kellman+P%2C+McVeigh+ER.+Image+reconstruction+in+SNR+units%3A+a+general+method+for+SNR+measurement.+Magn+Reson+Med.+2005%3B+54%3A1439-1447.&rft.au=Kellman%2C+Peter&rft.aulast=Kellman&rft.aufirst=Peter&rft.date=2007-07-01&rft.volume=58&rft.issue=1&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21261 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1002/mrm.21261 ER - TY - JOUR T1 - Hop2/Mnd1 acts on two critical steps in Dmc1-promoted homologous pairing AN - 20804713; 7530165 AB - Meiotic recombination between homologous chromosomes ensures their proper segregation at the first division of meiosis and is the main force shaping genetic variation of genomes. The HOP2 and MND1 genes are essential for this recombination: Their disruption results in severe defects in homologous chromosome synapsis and an early-stage failure in meiotic recombination. The mouse Hop2 and Mnd1 proteins form a stable heterodimer (Hop2/Mnd1) that greatly enhances Dmc1-mediated strand invasion. In order to elucidate the mechanism by which Hop2/Mnd1 stimulates Dmc1, we identify several intermediate steps in the homologous pairing reaction promoted by Dmc1. We show that Hop2/Mnd1 greatly stimulates Dmc1 to promote synaptic complex formation on long duplex DNAs, a step previously revealed only for bacterial homologous recombinases. This synaptic alignment is a consequence of the ability of Hop2/Mnd1 to (1) stabilize Dmc1-single-stranded DNA (ssDNA) nucleoprotein complexes, and (2) facilitate the conjoining of DNA molecules through the capture of double-stranded DNA by the Dmc1-ssDNA nucleoprotein filament. To our knowledge, Hop2/Mnd1 is the first homologous recombinase accessory protein that acts on these two separate and critical steps in mammalian meiotic recombination. JF - Genes & Development AU - Pezza, Roberto J AU - Voloshin, Oleg N AU - Vanevski, Filip AU - Camerini-Otero, RDaniel AD - Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 1758 EP - 1766 PB - Cold Spring Harbor Laboratory Press, Fulfillment & Distribution Dept. 500 Sunnyside Boulevard Woodbury NY 11797-2924 USA, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 21 IS - 14 SN - 0890-9369, 0890-9369 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts KW - Genomes KW - Recombination KW - Chromosomes KW - Meiosis KW - recombinase KW - Nucleoproteins KW - DNA KW - Genetic diversity KW - homologous recombination KW - Filaments KW - J 02310:Genetics & Taxonomy KW - N 14835:Protein-Nucleic Acids Association KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20804713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genes+%26+Development&rft.atitle=Hop2%2FMnd1+acts+on+two+critical+steps+in+Dmc1-promoted+homologous+pairing&rft.au=Pezza%2C+Roberto+J%3BVoloshin%2C+Oleg+N%3BVanevski%2C+Filip%3BCamerini-Otero%2C+RDaniel&rft.aulast=Pezza&rft.aufirst=Roberto&rft.date=2007-07-01&rft.volume=21&rft.issue=14&rft.spage=1758&rft.isbn=&rft.btitle=&rft.title=Genes+%26+Development&rft.issn=08909369&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; Recombination; Chromosomes; Meiosis; recombinase; Nucleoproteins; DNA; Genetic diversity; homologous recombination; Filaments ER - TY - JOUR T1 - Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury AN - 20747699; 7581702 AB - We recently used positional cloning to identify the transcription factor Nrf2 (NF-E2 related factor 2) as a susceptibility gene in a murine model of oxidant-induced acute lung injury (ALI). NRF2 binds to antioxidant response elements (ARE) and up-regulates protective detoxifying enzymes in response to oxidative stress. This led us to investigate NRF2 as a candidate susceptibility gene for risk of development of ALI in humans. We identified multiple single nucleotide polymorphisms (SNPs) by resequencing NRF2 in ethnically diverse subjects, and one (-617 C/A) significantly (P<0.001) diminished luciferase activity of promoter constructs containing the SNP and significantly decreased the binding affinity (P<0.001) relative to the wild type at this locus (-617 CC). In a nested case-control study, patients with the -617 A SNP had a significantly higher risk for developing ALI after major trauma (OR 6.44; 95% CI 1.34, 30.8; P=0.021) relative to patients with the wild type (-617 CC). This translational investigation provides novel insight into the molecular mechanisms of susceptibility to ALI and may help to identify patients who are predisposed to develop ALI under at risk conditions, such as trauma and sepsis. Furthermore, these findings may have important implications in other oxidative stress related illnesses. JF - FASEB Journal AU - Marzec, J M AU - Christie, J D AU - Reddy, S P AU - Jedlicka, A E AU - Vuong, H AU - Lanken, P N AU - Aplenc, R AU - Yamamoto, T AU - Yamamoto, M AU - Cho, H-Y AU - Kleeberger AD - National Institute of Environmental Health Sciences, 111 T.W. Alexander Dr., Bldg 101, Rm. D240, Research Triangle Park, North Carolina 27709, USA, kleeber1@niehs.nih.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 2237 EP - 2246 VL - 21 IS - 9 SN - 0892-6638, 0892-6638 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts KW - Risk assessment KW - Translation KW - Molecular modelling KW - Antioxidants KW - Injuries KW - Regulatory sequences KW - Animal models KW - Cloning KW - NRF2 protein KW - Enzymes KW - Trauma KW - Promoters KW - Sepsis KW - Lung KW - Oxidative stress KW - Single-nucleotide polymorphism KW - Risk factors KW - Transcription factors KW - J 02410:Animal Diseases KW - N 14835:Protein-Nucleic Acids Association KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20747699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+Journal&rft.atitle=Functional+polymorphisms+in+the+transcription+factor+NRF2+in+humans+increase+the+risk+of+acute+lung+injury&rft.au=Marzec%2C+J+M%3BChristie%2C+J+D%3BReddy%2C+S+P%3BJedlicka%2C+A+E%3BVuong%2C+H%3BLanken%2C+P+N%3BAplenc%2C+R%3BYamamoto%2C+T%3BYamamoto%2C+M%3BCho%2C+H-Y%3BKleeberger&rft.aulast=Marzec&rft.aufirst=J&rft.date=2007-07-01&rft.volume=21&rft.issue=9&rft.spage=2237&rft.isbn=&rft.btitle=&rft.title=FASEB+Journal&rft.issn=08926638&rft_id=info:doi/10.1096%2Ffj.06-7759com LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; Molecular modelling; Translation; Antioxidants; Injuries; Regulatory sequences; Cloning; Animal models; Enzymes; NRF2 protein; Trauma; Promoters; Sepsis; Single-nucleotide polymorphism; Oxidative stress; Lung; Transcription factors; Risk factors DO - http://dx.doi.org/10.1096/fj.06-7759com ER - TY - JOUR T1 - Interferon gamma, IL-12, IL-12R and STAT-1 immunodeficiency diseases: disorders of the interface of innate and adaptive immunity AN - 20734129; 8350444 AB - Susceptibility to mycobacterial infection has long been associated with defects in T cell immunity, such as those conferred by HIV infection or iatrogenic immune suppression. However, despite these well-recognized predispositions to clinical disease with tuberculosis and nontuberculous mycobacteria, the genetic disorders that are relatively specific for mycobacterial infection with nontuberculous bacteria and bacille Calmette Guerin (BCG) involve the innate immune pathways, and all engage interferon gamma and IL-12 production, signaling, and availability. JF - Immunologic Research AU - Holland, S M AD - Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, CRC B3-4141 MSC 1684, Bethesda, MD 20892-1684, USA, smh@nih.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 342 EP - 346 VL - 38 IS - 1-3 SN - 0257-277X, 0257-277X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - gamma -Interferon KW - Interleukin 12 KW - Human immunodeficiency virus KW - Mycobacterium KW - Stat1 protein KW - BCG KW - Immunodeficiency KW - Lymphocytes T KW - Tuberculosis KW - Infection KW - Signal transduction KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20734129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunologic+Research&rft.atitle=Interferon+gamma%2C+IL-12%2C+IL-12R+and+STAT-1+immunodeficiency+diseases%3A+disorders+of+the+interface+of+innate+and+adaptive+immunity&rft.au=Holland%2C+S+M&rft.aulast=Holland&rft.aufirst=S&rft.date=2007-07-01&rft.volume=38&rft.issue=1-3&rft.spage=342&rft.isbn=&rft.btitle=&rft.title=Immunologic+Research&rft.issn=0257277X&rft_id=info:doi/10.1007%2Fs12026-007-0045-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Interleukin 12; gamma -Interferon; BCG; Stat1 protein; Lymphocytes T; Immunodeficiency; Tuberculosis; Infection; Signal transduction; Mycobacterium; Human immunodeficiency virus DO - http://dx.doi.org/10.1007/s12026-007-0045-8 ER - TY - JOUR T1 - Body Mass and Colorectal Cancer Risk in the NIH-AARP Cohort AN - 20729798; 7460162 AB - In most studies, body mass index (BMI) has been associated with increased risk of colorectal or colon cancer in men, but the relation is weaker and less consistent for women, possibly because of interactions with age or hormone replacement therapy. The authors examined the relation between BMI and colorectal cancer incidence in a large, prospective US cohort of 307,708 men and 209,436 women from the NIH-AARP Diet and Health Study. During follow-up of the cohort from 1995 to 2000, 2,314 cases of colorectal cancer were observed in men and 1,029 in women. BMI was related to increased risk of incident colon cancer, but not rectal cancer, for both men and women. For men, relative risks of colon cancer for a BMI of 18.5-<23, 23-<25, 25-<27.5, 27.5-<30, 30-<32.5, 32.5-<35, 35-<40, and greater than or equal to 40 kg/m super(2) were 1.0 (referent), 1.11, 1.22, 1.44, 1.53, 1.57, 1.71, and 2.39, respectively (95% confidence interval: 1.59, 3.58; p-trend < 0.0005). Corresponding relative risks for women were 1.0, 1.20, 1.29, 1.31, 1.28, 1.13, 1.46, and 1.49 (95% confidence interval: 0.98, 2.25; p-trend = 0.02). BMI was related to colon cancer risk for younger (aged 50-66 years) but not older (aged 67-71 years) women. The association was not modified by hormone replacement therapy in women or physical activity in men or women. JF - American Journal of Epidemiology AU - Adams, Kenneth F AU - Leitzmann, Michael F AU - Albanes, Demetrius AU - Kipnis, Victor AU - Mouw, Traci AU - Hollenbeck, Al AU - Schatzkin, Arthur AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD Y1 - 2007/07/01/ PY - 2007 DA - 2007 Jul 01 SP - 36 EP - 45 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 166 IS - 1 SN - 0002-9262, 0002-9262 KW - Risk Abstracts KW - Diets KW - Age KW - colorectal carcinoma KW - body mass KW - physical activity KW - Cancer KW - hormone replacement therapy KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20729798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Body+Mass+and+Colorectal+Cancer+Risk+in+the+NIH-AARP+Cohort&rft.au=Adams%2C+Kenneth+F%3BLeitzmann%2C+Michael+F%3BAlbanes%2C+Demetrius%3BKipnis%2C+Victor%3BMouw%2C+Traci%3BHollenbeck%2C+Al%3BSchatzkin%2C+Arthur&rft.aulast=Adams&rft.aufirst=Kenneth&rft.date=2007-07-01&rft.volume=166&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diets; Age; body mass; colorectal carcinoma; physical activity; hormone replacement therapy; Cancer ER - TY - JOUR T1 - Smoking Cigarettes before First Childbirth and Risk of Breast Cancer AN - 20727907; 7460164 AB - Inconsistent epidemiologic findings on cigarette smoking and female breast cancer risk may reflect insufficient assessment of smoking onset and amount relative to reproductive events. To determine the risk of breast cancer associated with smoking during different periods of reproductive life, the authors evaluated 906 incident breast cancer cases in a nationwide cohort of 56,042 female US radiologic technologists (1983-1998) who responded to two questionnaire surveys. After they accounted for age, birth cohort, and established breast cancer risk factors, smoking-related breast cancer risks differed by smoking during three reproductive time periods (p = 0.003), with a statistically significant 3% increase per pack-year of smoking between menarche and first childbirth (relative risk = 1.03, 95% confidence interval: 1.02, 1.05) and no significant association for smoking after first childbirth. Risk also increased with younger age at smoking initiation (p-trend = 0.06), after adjustment for pack-years of smoking before and after first childbirth, indicating an independent effect of age at smoking initiation. The findings from this study suggest that sensitivity of the female breast to tobacco carcinogens is increased during adolescence and early adulthood but decreases after first childbirth, when most breast tissue has terminally differentiated. JF - American Journal of Epidemiology AU - Ha, Mina AU - Mabuchi, Kiyohiko AU - Sigurdson, Alice J AU - Freedman, DMichal AU - Linet, Martha S AU - Doody, Michele Morin AU - Hauptmann, Michael AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD Y1 - 2007/07/01/ PY - 2007 DA - 2007 Jul 01 SP - 55 EP - 61 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 166 IS - 1 SN - 0002-9262, 0002-9262 KW - Risk Abstracts KW - Sensitivity KW - Age KW - Cigarette smoking KW - Tobacco KW - Breast cancer KW - Carcinogens KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20727907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Smoking+Cigarettes+before+First+Childbirth+and+Risk+of+Breast+Cancer&rft.au=Ha%2C+Mina%3BMabuchi%2C+Kiyohiko%3BSigurdson%2C+Alice+J%3BFreedman%2C+DMichal%3BLinet%2C+Martha+S%3BDoody%2C+Michele+Morin%3BHauptmann%2C+Michael&rft.aulast=Ha&rft.aufirst=Mina&rft.date=2007-07-01&rft.volume=166&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Sensitivity; Age; Cigarette smoking; Tobacco; Breast cancer; Carcinogens; Cancer ER - TY - JOUR T1 - Fruit and Vegetable Intakes and Risk of Colorectal Cancer in the NIH-AARP Diet and Health Study AN - 20722074; 7528280 AB - The authors examined the associations between fruit and vegetable intakes and risk of colorectal cancer in the NIH-AARP Diet and Health Study. Diet was assessed with a food frequency questionnaire at baseline. Relative risks and 95% confidence intervals were estimated by using the Cox proportional hazards model. During 5-year follow-up of 488,043 men and women aged 50-71 years, 2,972 incident colorectal cancer cases were identified. The respective 10th and 90th percentiles of total fruit and vegetable intake (servings/1,000 kcal per day) were 1.4 and 5.2 for men and 1.8 and 6.5 for women. Compared with that for the lowest quintile of vegetable intake, the multivariate relative risk for the highest quintile was 0.82 (95% confidence interval: 0.71, 0.94) for men and 1.12 (95% confidence interval: 0.90, 1.38) for women. Increased risk of colorectal cancer was observed for very low intake of total fruits and vegetables by men (multivariate relative risk for <1 vs. greater than or equal to 2.0 servings/1,000 kcal per day = 1.26, 95% confidence interval: 1.03, 1.54). Among subgroups of vegetables, green leafy vegetables were associated with a lower risk of colorectal cancer for men (multivariate relative risk for the highest quintile vs. the lowest = 0.86, 95% confidence interval: 0.74, 0.99). Intake of fruits was not related to risk of colorectal cancer in men or women. JF - American Journal of Epidemiology AU - Park, Yikyung AU - Subar, Amy F AU - Kipnis, Victor AU - Thompson, Frances E AU - Mouw, Traci AU - Hollenbeck, Albert AU - Leitzmann, Michael F AU - Schatzkin, Arthur AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 170 EP - 180 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 166 IS - 2 SN - 0002-9262, 0002-9262 KW - Risk Abstracts KW - Diets KW - colorectal carcinoma KW - fruits KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20722074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Fruit+and+Vegetable+Intakes+and+Risk+of+Colorectal+Cancer+in+the+NIH-AARP+Diet+and+Health+Study&rft.au=Park%2C+Yikyung%3BSubar%2C+Amy+F%3BKipnis%2C+Victor%3BThompson%2C+Frances+E%3BMouw%2C+Traci%3BHollenbeck%2C+Albert%3BLeitzmann%2C+Michael+F%3BSchatzkin%2C+Arthur&rft.aulast=Park&rft.aufirst=Yikyung&rft.date=2007-07-01&rft.volume=166&rft.issue=2&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diets; colorectal carcinoma; fruits ER - TY - JOUR T1 - Tumor-Associated Embryonic Antigen-Expressing Vaccines that Target CCR6 Elicit Potent CD8 super(+) T Cell-Mediated Protective and Therapeutic Antitumor Immunity AN - 20720333; 7531694 AB - Despite its potency, the wider use of immunotherapy for B cell malignancies is hampered by the lack of well-defined tumor-specific Ags. In this study, we demonstrate that an evolutionarily conserved 37-kDa immature laminin receptor protein (OFA-iLRP), a nonimmunogenic embryonic Ag expressed by a variety of tumors, is rendered immunogenic if targeted to the APCs using the CCR6 ligands MIP3 alpha /CCL20 and mDF2 beta . The CCR6 targeting facilitated efficient Ag cross-presentation and induction of tumor-neutralizing CTLs. Although the Ag targeting alone, without activation of dendritic cells (DCs), is proposed to induce tolerance, and MIP3 alpha does not directly activate DCs, the MIP3 alpha -based vaccine efficiently induced protective and therapeutic antitumor responses. The responses were as strong as those elicited by the OFA-iLRP fusions with moieties that activated DCs and Th1-type cytokine responses, mDF2 beta , or mycobacterial Hsp70 Ag. Although the same cDNA encodes the dimerized high-affinity mature 67-kDa mLRP that is expressed in normal tissues to stabilize the binding of laminin to cell surface integrins, the vaccines expressing OFA-iLRP elicited long-term protective CD8 super(+) T cell-mediated memory responses against syngeneic B cell lymphoma, indicating the potential application of these simple vaccines as preventive and therapeutic formulations for human use. JF - Journal of Immunology AU - Biragyn, Arya AU - Schiavo, Roberta AU - Olkhanud, Purevdorj AU - Sumitomo, Kenya AU - King, Alan AU - McCain, Megan AU - Indig, Fred E AU - Almanzar, Giovanni AU - Baatar, Dolgor AD - Laboratory of Immunology and Research Resources Branch, Gerontology Research Center, National Institute on Aging, Baltimore, MD 21224. Cyto Pulse Sciences, Glen Burnie, MD 21061 Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 1381 EP - 1388 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 179 IS - 2 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Cancer vaccines KW - Cell surface KW - double prime B-cell lymphoma KW - Mycobacterium KW - CCR6 protein KW - Immunotherapy KW - Immunological memory KW - laminin receptors KW - Cell activation KW - Dendritic cells KW - Malignancy KW - Hsp70 protein KW - Integrins KW - adenomatous polyposis coli KW - Lymphocytes T KW - Cytokines KW - Embryos KW - Antigen-presenting cells KW - CCL20 protein KW - Laminin KW - Lymphocytes B KW - Memory cells KW - CD8 antigen KW - Tumors KW - Immunological tolerance KW - Cytotoxicity KW - Immunogenicity KW - Vaccines KW - Evolution KW - Antitumor activity KW - F 06915:Cancer Immunology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20720333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Tumor-Associated+Embryonic+Antigen-Expressing+Vaccines+that+Target+CCR6+Elicit+Potent+CD8+super%28%2B%29+T+Cell-Mediated+Protective+and+Therapeutic+Antitumor+Immunity&rft.au=Biragyn%2C+Arya%3BSchiavo%2C+Roberta%3BOlkhanud%2C+Purevdorj%3BSumitomo%2C+Kenya%3BKing%2C+Alan%3BMcCain%2C+Megan%3BIndig%2C+Fred+E%3BAlmanzar%2C+Giovanni%3BBaatar%2C+Dolgor&rft.aulast=Biragyn&rft.aufirst=Arya&rft.date=2007-07-01&rft.volume=179&rft.issue=2&rft.spage=1381&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell surface; Cancer vaccines; double prime B-cell lymphoma; Immunotherapy; CCR6 protein; Immunological memory; laminin receptors; Cell activation; Dendritic cells; Malignancy; Hsp70 protein; adenomatous polyposis coli; Integrins; Lymphocytes T; Cytokines; Embryos; Antigen-presenting cells; CCL20 protein; Laminin; Lymphocytes B; Memory cells; Tumors; CD8 antigen; Immunological tolerance; Cytotoxicity; Immunogenicity; Vaccines; Evolution; Antitumor activity; Mycobacterium ER - TY - JOUR T1 - Pesticide use and colorectal cancer risk in the agricultural health study AN - 20648478; 8079483 AB - We investigated the relationship between agricultural pesticides and colorectal cancer incidence in the Agricultural Health Study. A total of 56,813 pesticide applicators with no prior history of colorectal cancer were included in this analysis. Detailed pesticide exposure and other information were obtained from self-administered questionnaires completed at the time of enrollment (1993-1997). Cancer incidence was determined through population-based cancer registries from enrollment through December 31, 2002. A total of 305 incident colorectal cancers (212 colon, 93 rectum) were diagnosed during the study period, 1993-2002. Although most of the 50 pesticides studied were not associated with colorectal cancer risk, chlorpyrifos use showed significant exposure response trend (p for trend = 0.008) for rectal cancer, rising to a 2.7-fold (95% confidence interval: 1.2-6.4) increased risk in the highest exposure category. Aldicarb was associated with a significantly increased risk of colon cancer (p for trend = 0.001), based on a small number of exposed cases, with the highest exposure category resulting in a 4.1-fold increased risk (95% confidence interval: 1.3-12.8). In contrast, dichlorophenoxyacetic acid showed a significant inverse association with colon cancer but the association was not monotonic. Our findings should be interpreted cautiously since the literature suggesting that pesticides are related to colorectal cancer is limited. Nonetheless the possibility of an association between exposure to certain pesticides and incidence of colorectal cancer among pesticide applicators deserves further evaluation. JF - International Journal of Cancer AU - Lee, Won Jin AU - Sandler, Dale P AU - Blair, Aaron AU - Samanic, Claudine AU - Cross, Amanda J AU - Alavanja, Michael C R AD - Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea, alavanjm@mail.nih.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 339 EP - 346 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 121 IS - 2 SN - 0020-7136, 0020-7136 KW - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - Historical account KW - Inventories KW - Rectum KW - Colorectal cancer KW - Aldicarb KW - Colon cancer KW - Cancer KW - Chlorpyrifos KW - Risk factors KW - Pesticides KW - R2 23080:Industrial and labor KW - H 5000:Pesticides KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20648478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Pesticide+use+and+colorectal+cancer+risk+in+the+agricultural+health+study&rft.au=Lee%2C+Won+Jin%3BSandler%2C+Dale+P%3BBlair%2C+Aaron%3BSamanic%2C+Claudine%3BCross%2C+Amanda+J%3BAlavanja%2C+Michael+C+R&rft.aulast=Lee&rft.aufirst=Won&rft.date=2007-07-01&rft.volume=121&rft.issue=2&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22635 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Chlorpyrifos; Inventories; Rectum; Risk factors; Pesticides; Colorectal cancer; Aldicarb; Colon cancer; Historical account; Cancer DO - http://dx.doi.org/10.1002/ijc.22635 ER - TY - JOUR T1 - Perinatal exposure to environmental estrogens and the development of obesity AN - 20639400; 9378751 AB - Dietary substances and xenobiotic compounds with hormone-like activity can disrupt the programming of endocrine signaling pathways that are established during perinatal differentiation. The consequences of this disruption may not be apparent until later in life but increasing evidence implicates developmental exposure to environmental hormone-mimics with a growing list of adverse health effects including reproductive problems and increased cancer risks. Obesity has recently been proposed to be yet another adverse health consequence of exposure to endocrine disrupting substances during development. There is a renewed focus on identifying contributions of environmental factors to the development of obesity since it is reaching worldwide epidemic proportions, and this disease has the potential to overwhelm healthcare systems with associated illnesses such as diabetes and cardiovascular disease. Here, we review the literature that proposes an association of perinatal exposure to endocrine disrupting chemicals, in particular those with estrogenic activity, with the development of obesity later in life. We further describe an animal model of developmental exposure to diethylstilbestrol (DES) to study mechanisms involved in programming for obesity. Our experimental data support the idea that adipocytes and the mechanisms involved in weight homeostasis are novel targets of abnormal programming of environmental estrogens, some of which are found in our foods as naturally occurring substances or inadvertently as contaminants. JF - Molecular Nutrition & Food Research AU - Newbold, Retha R AU - Padilla-Banks, Elizabeth AU - Snyder, Ryan J AU - Jefferson, Wendy N AD - Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC, USA., newbold1@niehs.nih.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 912 EP - 917 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 51 IS - 7 SN - 1613-4125, 1613-4125 KW - Physical Education Index KW - Obesity KW - Health (care) KW - Programs KW - Literature reviews KW - Estrogen KW - Cardiorespiratory KW - Diseases KW - Diet KW - Hormones KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20639400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Nutrition+%26+Food+Research&rft.atitle=Perinatal+exposure+to+environmental+estrogens+and+the+development+of+obesity&rft.au=Newbold%2C+Retha+R%3BPadilla-Banks%2C+Elizabeth%3BSnyder%2C+Ryan+J%3BJefferson%2C+Wendy+N&rft.aulast=Newbold&rft.aufirst=Retha&rft.date=2007-07-01&rft.volume=51&rft.issue=7&rft.spage=912&rft.isbn=&rft.btitle=&rft.title=Molecular+Nutrition+%26+Food+Research&rft.issn=16134125&rft_id=info:doi/10.1002%2Fmnfr.200600259 LA - English DB - Physical Education Index N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Obesity; Programs; Health (care); Literature reviews; Estrogen; Cardiorespiratory; Diet; Diseases; Hormones DO - http://dx.doi.org/10.1002/mnfr.200600259 ER - TY - JOUR T1 - Place of Residence Effect on Likelihood of Surviving Prostate Cancer AN - 20569212; 9270995 AB - Purpose To examine geographic variation in survival time of men diagnosed with prostate cancer, adjusted for patient and disease characteristics. Method Survival times for a geographically referenced database of 27,189 incident prostate cancer cases (ICD-O-2: C61.9) from Connecticut, 1984-1998, were evaluated using a newly developed extension of the spatial scan statistic for survival data. Results Statewide, median survival time was 4.6 years following diagnosis. Age-adjusted survival times across most locales around Connecticut did not differ markedly from the statewide pattern, but our analysis revealed 3 zones with noteworthy differences. Analysis of survival times adjusted for age as well as tumor grade and stage produced only two locations with significant results, and further adjustment for racial composition of cases yielded only one location with significant distinct (lower) survival times. Among cases within that place, the likelihood of dying was estimated to be 1.39-times greater than that of cases different from those diagnosed elsewhere around the state (p = 0.009). Conclusion The prognosis for men with prostate cancer may differ, in part, by virtue of where they live when diagnosed. Measuring geographic differences in survival time should facilitate the targeting of clinical and ancillary services to persons at high risk of poor outcomes. Key Words: Prostate Cancer; Survival; Geography Abbreviations: CTR, Connecticut Tumor Registry; ICD-O-2, International Classification of Diseases for Oncology, second edition; O/E, observed/expected JF - Annals of Epidemiology AU - Gregorio, David I AU - Huang, Lan AU - Dechello, Laurie M AU - Samociuk, Holly AU - Kulldorff, Martin AD - From the Department of Community Medicine & Health Care, University of Connecticut School of Medicine, Farmington (D.I.G., L.M.D., H.S.); Statistical Applications and Research Branch, Division of Cancer Control and Population Studies, National Cancer Institute (L.H.); and the Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA (M.K.), gregorio@nso.uchc.edu Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 520 EP - 524 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 17 IS - 7 SN - 1047-2797, 1047-2797 KW - Risk Abstracts KW - Age KW - USA, Connecticut KW - classification KW - tumors KW - survival KW - prostate cancer KW - Geography KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20569212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Place+of+Residence+Effect+on+Likelihood+of+Surviving+Prostate+Cancer&rft.au=Gregorio%2C+David+I%3BHuang%2C+Lan%3BDechello%2C+Laurie+M%3BSamociuk%2C+Holly%3BKulldorff%2C+Martin&rft.aulast=Gregorio&rft.aufirst=David&rft.date=2007-07-01&rft.volume=17&rft.issue=7&rft.spage=520&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Age; classification; tumors; Geography; prostate cancer; survival; USA, Connecticut ER - TY - JOUR T1 - Akt blocks ligand binding and protects against expanded polyglutamine androgen receptor toxicity AN - 20550158; 7462000 AB - Spinal and bulbar muscular atrophy (SBMA) is a progressive neurodegenerative disease caused by an expansion of the polyglutamine tract in the androgen receptor (AR). Here, we investigated the regulation of AR phosphorylation in order to understand factors that may modify SBMA disease progression. We show that expanded polyglutamine AR is phosphorylated by Akt. Substitution of the AR at two Akt consensus sites, S215 and S792, with aspartate, which mimics phosphorylation, reduces ligand binding, ligand-dependent nuclear translocation, transcriptional activation and toxicity of expanded polyglutamine AR. Co-expression of constitutively active Akt and the AR has similar consequences, which are blocked by alanine substitutions at residues 215 and 792. Furthermore, in motor neuron-derived MN-1 cells toxicity associated with polyglutamine-expanded AR is rescued by co-expression with Akt. Insulin-like growth factor-1 (IGF-1) stimulation, which activates several cell survival promoting pathways, also reduces toxicity of the expanded polyglutamine AR in MN-1 cells, in a manner dependent upon phospho-inositol-3-kinase. IGF-1 rescue of AR toxicity is diminished by alanine substitutions at the Akt consensus sites. These results highlight potential targets for therapeutic intervention in SBMA. JF - Human Molecular Genetics AU - Palazzolo, Isabella AU - Burnett, Barrington G AU - Young, Jessica E AU - Brenne, Phebe L AU - La Spada, Albert R AU - Fischbeck, Kenneth H AU - Howell, Brian W AU - Pennuto, Maria AD - Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892, USA and. Departments of Laboratory Medicine, Medicine and Neurology, and Center for Neurogenetics and Neurotherapeutics, University of Washington, Seattle, WA, USA Y1 - 2007/07/01/ PY - 2007 DA - 2007 Jul 01 SP - 1593 EP - 1603 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 16 IS - 13 SN - 0964-6906, 0964-6906 KW - Toxicology Abstracts; Genetics Abstracts; CSA Neurosciences Abstracts KW - Cell survival KW - Insulin-like growth factor I KW - spinal and bulbar muscular atrophy KW - Alanine KW - Therapeutic applications KW - Toxicity KW - Androgen receptors KW - Nuclear transport KW - Neurodegenerative diseases KW - Phosphorylation KW - Polyglutamine KW - AKT protein KW - Transcription activation KW - X 24500:Reviews, Legislation, Book & Conference Notices KW - G 07880:Human Genetics KW - N3 11023:Neurogenetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20550158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Molecular+Genetics&rft.atitle=Akt+blocks+ligand+binding+and+protects+against+expanded+polyglutamine+androgen+receptor+toxicity&rft.au=Palazzolo%2C+Isabella%3BBurnett%2C+Barrington+G%3BYoung%2C+Jessica+E%3BBrenne%2C+Phebe+L%3BLa+Spada%2C+Albert+R%3BFischbeck%2C+Kenneth+H%3BHowell%2C+Brian+W%3BPennuto%2C+Maria&rft.aulast=Palazzolo&rft.aufirst=Isabella&rft.date=2007-07-01&rft.volume=16&rft.issue=13&rft.spage=1593&rft.isbn=&rft.btitle=&rft.title=Human+Molecular+Genetics&rft.issn=09646906&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell survival; Insulin-like growth factor I; spinal and bulbar muscular atrophy; Alanine; Therapeutic applications; Toxicity; Androgen receptors; Neurodegenerative diseases; Nuclear transport; Phosphorylation; AKT protein; Polyglutamine; Transcription activation ER - TY - JOUR T1 - Commentary on increased risk of biochemical and local failure in patients with a distended rectum on the planning CT for prostate cancer radiotherapy AN - 20542151; 8067507 AB - Abstract not available. JF - International Journal of Radiation Oncology, Biology, & Physics AU - Roach III, Mack AD - Departments of Radiation Oncology and Urology, University of California San Francisco, UCSF/Mt. Zion NCI-Designated Comprehensive Cancer, San Francisco, CA Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 949 EP - 950 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 62 IS - 4 SN - 0360-3016, 0360-3016 KW - Biotechnology and Bioengineering Abstracts KW - Prostate cancer KW - Rectum KW - Radiotherapy KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20542151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Radiation+Oncology%2C+Biology%2C+%26+Physics&rft.atitle=Commentary+on+increased+risk+of+biochemical+and+local+failure+in+patients+with+a+distended+rectum+on+the+planning+CT+for+prostate+cancer+radiotherapy&rft.au=Roach+III%2C+Mack&rft.aulast=Roach+III&rft.aufirst=Mack&rft.date=2007-07-01&rft.volume=62&rft.issue=4&rft.spage=949&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Radiation+Oncology%2C+Biology%2C+%26+Physics&rft.issn=03603016&rft_id=info:doi/10.1016%2Fj.ijrobp.2005.03.067 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Rectum; Prostate cancer; Radiotherapy DO - http://dx.doi.org/10.1016/j.ijrobp.2005.03.067 ER - TY - JOUR T1 - Validation of Dynamic Contrast-Enhanced Magnetic Resonance Imaging-Derived Vascular Permeability Measurements Using Quantitative Autoradiography in the RG2 Rat Brain Tumor Model AN - 20528242; 7791753 AB - Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is widely used to evaluate tumor permeability, yet measurements have not been directly validated in brain tumors. Our purpose was to compare estimates of forward leakage K super(trans) derived from DCE-MRI to the estimates K obtained using [ super(14)C]aminoisobutyric acid quantitative autoradiography ([ super(14)C]AIB QAR), an established method of evaluating blood-tumor barrier permeability. Both DCE-MRI and [ super(14)C]AIB QAR were performed in five rats 9 to 11 days following tumor implantation, K super(trans) in the tumor was estimated from DCE-MRI using the three-parameter general kinetic model and a measured vascular input function. K sub(i) was estimated from QAR data using regions of interest (ROI) closely corresponding to those used to estimate K super(trans). K super(trans) and K sub(i) correlated with each other for two independent sets of central tumor ROI (R = 0.905, P = .035; R = 0.933, P = .021). In an additional six rats, K super(trans) was estimated on two occasions to show reproducibility (intraclass coefficient = 0.9993; coefficient of variance = 6.07%). In vivo blood-tumor permeability parameters derived from DCE-MRI are reproducible and correlate with the gold standard for quantifying blood tumor barrier permeability, [ super(14)C]AIB QAR. JF - Neoplasia AU - Ferrier, M C AU - Sarin, H AU - Fung, SH AU - Schatlo, B AU - Pluta, R M AU - Gupta, S N AU - Choyke, P L AU - Oldfield, E H AU - Thomasson, D AU - Butman, JA AD - Diagnostic Radiology Department, Imaging Sciences Program, The Clinical Center of the National Institutes of Health, Bethesda, MD, USA, jbutmana@cc.nih.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 546 EP - 555 VL - 9 IS - 7 SN - 1522-8002, 1522-8002 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Leakage KW - Magnetic resonance imaging KW - Animal models KW - Autoradiography KW - Brain tumors KW - Blood KW - Permeability KW - Kinetics KW - Vascular system KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20528242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neoplasia&rft.atitle=Validation+of+Dynamic+Contrast-Enhanced+Magnetic+Resonance+Imaging-Derived+Vascular+Permeability+Measurements+Using+Quantitative+Autoradiography+in+the+RG2+Rat+Brain+Tumor+Model&rft.au=Ferrier%2C+M+C%3BSarin%2C+H%3BFung%2C+SH%3BSchatlo%2C+B%3BPluta%2C+R+M%3BGupta%2C+S+N%3BChoyke%2C+P+L%3BOldfield%2C+E+H%3BThomasson%2C+D%3BButman%2C+JA&rft.aulast=Ferrier&rft.aufirst=M&rft.date=2007-07-01&rft.volume=9&rft.issue=7&rft.spage=546&rft.isbn=&rft.btitle=&rft.title=Neoplasia&rft.issn=15228002&rft_id=info:doi/10.1593%2Fneo.07289 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Permeability; Animal models; Vascular system; Brain tumors; Magnetic resonance imaging; Autoradiography; Blood; Kinetics; Leakage DO - http://dx.doi.org/10.1593/neo.07289 ER - TY - JOUR T1 - Mitochondrial Introgressions into the Nuclear Genome of the Domestic Cat AN - 20496021; 7558546 AB - Translocation of mtDNA into the nuclear genome, also referred to as numt, was first reported in the domestic cat (Felis catus) by Lopez et al. (1994). The Lopez-numt consisted of a translocation of 7.9 kbp of mtDNA that inserted into the domestic cat chromosome D2 around 1.8 million years ago. More than a decade later, the release of the domestic cat whole-genome shotgun sequences (1.9x coverage) provides the resource to obtain more comprehensive insight into the extent of mtDNA transfer over time in the domestic cat genome. MegaBLAST searches revealed that the cat genome harbors a wide variety of numts (298 320 bp), one-third of which likely correspond to the Lopez-numt tandem repeat, whereas the remaining numts are probably derived from multiple independent insertions, which in some cases were followed by segmental duplication after insertion in the nucleus. Numts were detected across most cat chromosomes, but the number of numts assigned to chromosomes is underestimated due to the relatively high number of numt sequences with insufficient flanking sequence to map. The catalog of cat numts provides a valuable resource for future studies in Felidae species, including its use as a tool to avoid numt contaminations that may confound population genetics and phylogenetic studies. JF - Journal of Heredity AU - Antunes, Agostinho AU - Pontius, Joan AU - Ramos, Maria Joao AU - O'Brien, Stephen J AU - Johnson, Warren E AD - Laboratory of Genomic Diversity, National Cancer Institute-Frederick Cancer Research and Development Center (NCI-FCRDC), Frederick, MD 21702-1201 (Antunes, O'Brien, and Johnson) Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 414 EP - 420 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 98 IS - 5 SN - 0022-1503, 0022-1503 KW - Cats KW - House cat KW - domestic cat KW - Ecology Abstracts; Genetics Abstracts KW - Genomes KW - Phylogeny KW - Catalogs KW - Contamination KW - Mitochondria KW - Population genetics KW - Nuclear transport KW - Mitochondrial DNA KW - Felidae KW - Chromosome translocations KW - Felis catus KW - Insertion KW - Nuclei KW - D 04040:Ecosystem and Ecology Studies KW - G 07750:Ecological & Population Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20496021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Heredity&rft.atitle=Mitochondrial+Introgressions+into+the+Nuclear+Genome+of+the+Domestic+Cat&rft.au=Antunes%2C+Agostinho%3BPontius%2C+Joan%3BRamos%2C+Maria+Joao%3BO%27Brien%2C+Stephen+J%3BJohnson%2C+Warren+E&rft.aulast=Antunes&rft.aufirst=Agostinho&rft.date=2007-07-01&rft.volume=98&rft.issue=5&rft.spage=414&rft.isbn=&rft.btitle=&rft.title=Journal+of+Heredity&rft.issn=00221503&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Phylogeny; Genomes; Nuclear transport; Population genetics; Mitochondrial DNA; Catalogs; Contamination; Chromosome translocations; Insertion; Mitochondria; Nuclei; Felidae; Felis catus ER - TY - JOUR T1 - Refinement of protein structure against non-redundant carbonyl super(13)C NMR relaxation AN - 20479688; 7953566 AB - Carbonyl super(13)C' relaxation is dominated by the contribution from the super(13)C' chemical shift anisotropy (CSA). The relaxation rates provide useful and non-redundant structural information in addition to dynamic parameters. It is straightforward to acquire, and offers complimentary structural information to the super(15)N relaxation data. Furthermore, the non-axial nature of the super(13)C' CSA tensor results in a T sub(1)/T sub(2) value that depends on an additional angular variable even when the diffusion tensor of the protein molecule is axially symmetric. This dependence on an extra degree of freedom provides new geometrical information that is not available from the NH dipolar relaxation. A protocol that incorporates such structural restraints into NMR structure calculation was developed within the program Xplor-NIH. Its application was illustrated with the yeast Fis1 NMR structure. Refinement against the super(13)C' T sub(1)/T sub(2) improved the overall quality of the structure, as evaluated by cross-validation against the residual dipolar coupling as well as the super(15)N relaxation data. In addition, possible variations of the CSA tensor were addressed. JF - Journal of Biomolecular NMR AU - Tjandra, Nico AU - Suzuki, Motoshi AU - Chang, Shou-Lin AD - National Heart, Lung, and Blood Institute, National Institutes of Health, Building 50, Room 3503, Bethesda, MD, 20892, USA, nico@helix.nih.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 243 EP - 253 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 38 IS - 3 SN - 0925-2738, 0925-2738 KW - Biotechnology and Bioengineering Abstracts KW - Protein structure KW - Data processing KW - Anisotropy KW - N.M.R. KW - carbonyls KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20479688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomolecular+NMR&rft.atitle=Refinement+of+protein+structure+against+non-redundant+carbonyl+super%2813%29C+NMR+relaxation&rft.au=Tjandra%2C+Nico%3BSuzuki%2C+Motoshi%3BChang%2C+Shou-Lin&rft.aulast=Tjandra&rft.aufirst=Nico&rft.date=2007-07-01&rft.volume=38&rft.issue=3&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomolecular+NMR&rft.issn=09252738&rft_id=info:doi/10.1007%2Fs10858-007-9165-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Protein structure; Anisotropy; Data processing; N.M.R.; carbonyls DO - http://dx.doi.org/10.1007/s10858-007-9165-7 ER - TY - JOUR T1 - Pharmacogenomic analyses of targeting the AT-rich malaria parasite genome with AT-specific alkylating drugs AN - 20465731; 7585897 AB - Human malaria parasites, including the most lethal Plasmodium falciparum, are increasingly resistant to existing antimalarial drugs. One remarkable opportunity to selectively target P. falciparum stems from the unique AT-richness of its genome (80% A/T, relative to 60% in human DNA). To rationally explore this opportunity, we used drugs (adozelesin and bizelesin) which distinctly target AT-rich minisatellites and an in silico approach for genome-wide analysis previously experimentally validated in human cells [Woynarowski JM, Trevino AV, Rodriguez KA, Hardies SC, Benham CJ. AT-rich islands in genomic DNA as a novel target for AT-specific DNA-reactive antitumor drugs. J Biol Chem 2001; 276:40555-66]. Both drugs demonstrate a potent, rapid and irreversible inhibition of the cultured P. falciparum (50% inhibition at 110 and 10±2.3pM, respectively). This antiparasital activity reflects most likely drug binding to specific super-AT-rich regions. Relative to the human genome, the P. falciparum genome shows 3.9- and 7-fold higher frequency of binding sites for adozelesin and bizelesin, respectively. The distribution of these sites is non-random with the most prominent clusters found in large unique minisatellites [median size 3.5kbp of nearly pure A/T, with multiple converging repeats but no shared consensus other than (A/T)n]. Each of the fourteen P. falciparum chromosomes contains only one such 'super-AT island' located within 3-7.5kbp of gene-free and nucleosome-free loci. Important functions of super-AT islands are suggested by their exceptional predicted potential to serve as matrix attachment regions (MARs) and a precise co-localization with the putative centromeres. Conclusion Super-AT islands, identified as unique domains in the P. falciparum genome with presumably crucial functions, offer therapeutically exploitable opportunity for new antimalarial strategies. JF - Molecular and Biochemical Parasitology AU - Woynarowski, Jan M AU - Krugliak, Miriam AU - Ginsburg, Hagai AD - Department of Radiation Oncology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA, woynarowskij@mail.nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 70 EP - 81 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl] VL - 154 IS - 1 SN - 0166-6851, 0166-6851 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Plasmodium falciparum KW - Malaria KW - A/T-rich KW - AT islands KW - Matrix attachment regions (MARs, S/MARs) KW - Centromeres KW - Nucleosome-free regions KW - Antimalarial activity KW - Adozelesin KW - Bizelesin KW - Genomes KW - Parasites KW - Human diseases KW - matrix attachment regions KW - pharmacogenomics KW - Public health KW - Chromosomes KW - DNA KW - genomics KW - Drugs KW - K 03340:Effects of Physical & Chemical Factors KW - G 07790:Other Microorganisms KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20465731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Biochemical+Parasitology&rft.atitle=Pharmacogenomic+analyses+of+targeting+the+AT-rich+malaria+parasite+genome+with+AT-specific+alkylating+drugs&rft.au=Woynarowski%2C+Jan+M%3BKrugliak%2C+Miriam%3BGinsburg%2C+Hagai&rft.aulast=Woynarowski&rft.aufirst=Jan&rft.date=2007-07-01&rft.volume=154&rft.issue=1&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Biochemical+Parasitology&rft.issn=01666851&rft_id=info:doi/10.1016%2Fj.molbiopara.2007.04.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Genomes; Parasites; Chromosomes; Human diseases; DNA; Malaria; Drugs; Public health; matrix attachment regions; pharmacogenomics; genomics; Centromeres; Plasmodium falciparum DO - http://dx.doi.org/10.1016/j.molbiopara.2007.04.009 ER - TY - JOUR T1 - Successive glycosyltransfer of sialic acid by Escherichia coli K92 polysialyltransferase in elongation of oligosialic acceptors AN - 20463923; 9145628 AB - Escherichia coli K92 produces a capsular polysialic acid with alternating alpha 2,8 alpha 2,9 NeuNAc linkages. This polysaccharide is cross-reactive with the neuroinvasive pathogen Neisseria meningitidis Group C. The K92 polysialyltransferase (PST) catalyzes the synthesis of the polysialic acid with alternating linkages by the transfer of NeuNAc from CMP-NeuNAc to the nonreducing end of the growing polymer. We used a fluorescent-based high-performance liquid chromatography assay to characterize the process of chain extension. The PST elongates the acceptor GT3-FCHASE in a biphasic fashion. The initial phase polymers are characterized by accumulation of product containing 1-8 additional sialic acid residues. This phase is followed by a very rapid formation of high-molecular weight (MW) polymer as the accumulated oligosaccharides containing 8-10 sialic acids are consumed. The high-MW polymer contains 90-100 sialic acids and is sensitive to degradation by periodate and K1-5 endoneuraminidase, suggesting that the polymer contains the alternating structure. The polymerization reaction does not appear to be strictly processive, since oligosaccharides of each intermediate size were detected before accumulation of high-molecular weight polymer. Synthesis can be blocked by CMP-9-azido-NeuNAc. These results suggest that the K92 PST forms both alpha 2,8 and alpha 2,9 linkages in a successive and nonprocessive fashion. JF - Glycobiology AU - Vionnet, Justine AU - Vann, Willie F AD - Laboratory of Bacterial Polysaccharides , Center for Biologics Evaluation and Research, FDA , Bethesda, MD 20892, wvann@helix.nih.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 735 EP - 743 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 17 IS - 7 SN - 0959-6658, 0959-6658 KW - Microbiology Abstracts B: Bacteriology KW - capsular polysaccharide KW - chain extension KW - polysialyltransferase KW - processivity KW - sialic acid KW - High-performance liquid chromatography KW - Invasiveness KW - oligosaccharides KW - Polymerization KW - Neisseria meningitidis KW - Pathogens KW - Polysaccharides KW - Elongation KW - Escherichia coli KW - polysialic acid KW - Sialic acids KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20463923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Glycobiology&rft.atitle=Successive+glycosyltransfer+of+sialic+acid+by+Escherichia+coli+K92+polysialyltransferase+in+elongation+of+oligosialic+acceptors&rft.au=Vionnet%2C+Justine%3BVann%2C+Willie+F&rft.aulast=Vionnet&rft.aufirst=Justine&rft.date=2007-07-01&rft.volume=17&rft.issue=7&rft.spage=735&rft.isbn=&rft.btitle=&rft.title=Glycobiology&rft.issn=09596658&rft_id=info:doi/10.1093%2Fglycob%2Fcwm032 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Elongation; Invasiveness; Polymerization; oligosaccharides; polysialyltransferase; Pathogens; polysialic acid; Polysaccharides; Sialic acids; Escherichia coli; Neisseria meningitidis DO - http://dx.doi.org/10.1093/glycob/cwm032 ER - TY - JOUR T1 - Chromosome 8 BAC array comparative genomic hybridization and expression analysis identify amplification and overexpression of TRMT12 in breast cancer AN - 20449016; 7913367 AB - Genomic changes in chromosome 8 are commonly observed in breast cancer cell lines and tumors. To fine map such genomic changes by comparative genomic hybridization (CGH), a high resolution (100 kb) chromosome 8 array that can detect single copy changes was developed using Phi29 DNA polymerase amplified BAC (bacterial artificial chromosome) DNA. The BAC array CGH resolved the two known amplified regions (8q21 and 8q24) of a breast cancer cell line (SKBR3) into nine separate regions including six amplicons and three deleted regions, all of which were verified by Fluorescence in situ hybridization. The extent of the gain/loss for each region was validated by qPCR. CGH was performed with a total of 8 breast cancer cell lines, and common regions of genomic amplification/deletion were identified by segmentation analysis. A 1.2-Mb region (125.3-126.5 Mb) and a 1.0-Mb region (128.1-129.1 Mb) in 8q24 were amplified in 7/8 cell lines. A global expression analysis was performed to evaluate expression changes associated with genomic amplification/deletion: a novel gene, TRMT12 (at 125.5 Mb), amplified in 7/8 cell lines, showed highest expression in these cell lines. Further analysis by RT-qPCR using RNA from 30 breast tumors showed that TRMT12 was overexpressed >2 fold in 87% (26/30) of the tumors. TRMT12 is a homologue of a yeast gene encoding a tRNA methyltransferase involved in the posttranscriptional modification of tRNAPhe, and exploring the biological consequence of its altered expression, may reveal novel pathways in tumorigenesis. This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045-2257/pmat. Published 2007 Wiley-Liss, Inc. JF - Genes, Chromosomes and Cancer AU - Rodriguez, Virginia AU - Chen, Yidong AU - Elkahloun, Abdel AU - Dutra, Amalia AU - Pak, Evgenia AU - Chandrasekharappa, Settara AD - Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, chandra@mail.nih.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 694 EP - 707 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 46 IS - 7 SN - 1045-2257, 1045-2257 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Tumorigenesis KW - Bacterial artificial chromosomes KW - chromosome 8 KW - Gene deletion KW - Tumor cell lines KW - RNA KW - DNA-directed DNA polymerase KW - Segmentation KW - Breast cancer KW - genomics KW - Post-transcription KW - tRNA methyltransferase KW - Fluorescence in situ hybridization KW - J 02320:Cell Biology KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20449016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genes%2C+Chromosomes+and+Cancer&rft.atitle=Chromosome+8+BAC+array+comparative+genomic+hybridization+and+expression+analysis+identify+amplification+and+overexpression+of+TRMT12+in+breast+cancer&rft.au=Rodriguez%2C+Virginia%3BChen%2C+Yidong%3BElkahloun%2C+Abdel%3BDutra%2C+Amalia%3BPak%2C+Evgenia%3BChandrasekharappa%2C+Settara&rft.aulast=Rodriguez&rft.aufirst=Virginia&rft.date=2007-07-01&rft.volume=46&rft.issue=7&rft.spage=694&rft.isbn=&rft.btitle=&rft.title=Genes%2C+Chromosomes+and+Cancer&rft.issn=10452257&rft_id=info:doi/10.1002%2Fgcc.20454 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Tumorigenesis; Bacterial artificial chromosomes; chromosome 8; Tumor cell lines; Gene deletion; RNA; DNA-directed DNA polymerase; Segmentation; Breast cancer; genomics; Post-transcription; tRNA methyltransferase; Fluorescence in situ hybridization DO - http://dx.doi.org/10.1002/gcc.20454 ER - TY - JOUR T1 - Prospects for a dengue virus vaccine AN - 20361865; 7565503 AB - The number of cases of severe dengue disease continues to grow in endemic areas of southeast Asia, Central and South America, and other subtropical regions. Children bear the greatest burden of disease, and the development of an effective vaccine remains a global public health priority. A tetravalent vaccine is urgently needed and must be effective against all four dengue virus serotypes, be cost-effective and provide long-term protection. In this Review we discuss the unique immunological concerns in dengue virus vaccine development and the current prospects for the development of an acceptable vaccine, a goal that is likely to be reached in the near future. JF - Nature Reviews: Microbiology AU - Whitehead, Stephen S AU - Blaney, Joseph E AU - Durbin, Anna P AU - Murphy, Brian R AD - Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA., swhitehead@niaid.nih.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 518 EP - 528 PB - Nature Publishing Co., 345 Park Ave. S. 10th Floor New York NY 10010-1707 USA, [mailto:nature@natureny.com], [URL:http://www.nature.com/nature/] VL - 5 IS - 7 SN - 1740-1526, 1740-1526 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Dengue virus KW - Serotypes KW - Dengue KW - Reviews KW - Vaccines KW - Children KW - Public health KW - F 06905:Vaccines KW - V 22350:Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20361865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Microbiology&rft.atitle=Prospects+for+a+dengue+virus+vaccine&rft.au=Whitehead%2C+Stephen+S%3BBlaney%2C+Joseph+E%3BDurbin%2C+Anna+P%3BMurphy%2C+Brian+R&rft.aulast=Whitehead&rft.aufirst=Stephen&rft.date=2007-07-01&rft.volume=5&rft.issue=7&rft.spage=518&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Microbiology&rft.issn=17401526&rft_id=info:doi/10.1038%2Fnrmicro1690 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Serotypes; Dengue; Reviews; Vaccines; Children; Public health; Dengue virus DO - http://dx.doi.org/10.1038/nrmicro1690 ER - TY - JOUR T1 - Translational Regulation of the Escherichia coli Stress Factor RpoS: a Role for SsrA and Lon AN - 20346648; 7462545 AB - Escherichia coli cell viability during starvation is strongly dependent on the expression of the rpoS gene, encoding the RpoS sigma subunit of RNA polymerase. RpoS abundance has been reported to be regulated at many levels, including transcription initiation, translation, and protein stability. The regulatory RNA SsrA (or tmRNA) has both tRNA and mRNA activities, relieving ribosome stalling and cotranslationally tagging proteins. We report here that SsrA is needed for the correct high-level translation of RpoS. The ATP-dependent protease Lon was also found to negatively affect RpoS translation, but only at low temperature. We suggest that SsrA may indirectly improve RpoS translation by limiting ribosome stalling and depletion of some component of the translation machinery. JF - Journal of Bacteriology AU - Ranquet, Caroline AU - Gottesman, Susan AD - Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892 Y1 - 2007/07/01/ PY - 2007 DA - 2007 Jul 01 SP - 4872 EP - 4879 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 189 IS - 13 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Temperature effects KW - Starvation KW - Translation KW - Translation initiation KW - tRNA KW - Stress KW - Ribosomes KW - rpoS gene KW - Transcription initiation KW - DNA-directed RNA polymerase KW - tmRNA KW - Escherichia coli KW - Proteinase KW - J 02310:Genetics & Taxonomy KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20346648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Translational+Regulation+of+the+Escherichia+coli+Stress+Factor+RpoS%3A+a+Role+for+SsrA+and+Lon&rft.au=Ranquet%2C+Caroline%3BGottesman%2C+Susan&rft.aulast=Ranquet&rft.aufirst=Caroline&rft.date=2007-07-01&rft.volume=189&rft.issue=13&rft.spage=4872&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Starvation; Temperature effects; Translation; DNA-directed RNA polymerase; tmRNA; Translation initiation; tRNA; Stress; Proteinase; Ribosomes; rpoS gene; Transcription initiation; Escherichia coli ER - TY - JOUR T1 - High-field MRI of brain cortical substructure based on signal phase AN - 20301594; 7533208 AB - The ability to detect brain anatomy and pathophysiology with MRI is limited by the contrast-to-noise ratio (CNR), which depends on the contrast mechanism used and the spatial resolution. In this work, we show that in MRI of the human brain, large improvements in contrast to noise in high-resolution images are possible by exploiting the MRI signal phase at high magnetic field strength. Using gradient-echo MRI at 7.0 tesla and a multichannel detector, a nominal voxel size of 0.24 x 0.24 x 1.0 mm super(3) (58 nl) was achieved. At this resolution, a strong phase contrast was observed both between as well as within gray matter (GM) and white matter (WM). In gradient-echo phase images obtained on normal volunteers at this high resolution, the CNR between GM and WM ranged from 3:1 to 20:1 over the cortex. This CNR is an almost 10-fold improvement over conventional MRI techniques that do not use image phase, and it is an approximately 100-fold improvement when including the gains in resolution from high-field and multichannel detection. Within WM, phase contrast appeared to be associated with the major fiber bundles, whereas contrast within GM was suggestive of the underlying layer structure. The observed phase contrast is attributed to local variations in magnetic susceptibility, which, at least in part, appeared to originate from iron stores. The ability to detect cortical substructure from MRI phase contrast at high field is expected to greatly enhance the study of human brain anatomy in vivo. JF - Proceedings of the National Academy of Sciences, USA AU - Duyn, Jeff H AU - van Gelderen, Peter AU - Li, Tie-Qiang AU - de Zwart, Jacco A AU - Koretsky, Alan P AU - Fukunaga, Masaki AD - Laboratory for Advanced MRI, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, Room B1D-728, 9000 Rockville Pike, Bethesda, MD 20892-1065 Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 11796 EP - 11801 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 28 SN - 0027-8424, 0027-8424 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Magnetic fields KW - Fibers KW - Cortex KW - Magnetic resonance imaging KW - Brain KW - Noise KW - Substantia alba KW - Magnetic susceptibility KW - Iron KW - Substantia grisea KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20301594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=High-field+MRI+of+brain+cortical+substructure+based+on+signal+phase&rft.au=Duyn%2C+Jeff+H%3Bvan+Gelderen%2C+Peter%3BLi%2C+Tie-Qiang%3Bde+Zwart%2C+Jacco+A%3BKoretsky%2C+Alan+P%3BFukunaga%2C+Masaki&rft.aulast=Duyn&rft.aufirst=Jeff&rft.date=2007-07-01&rft.volume=104&rft.issue=28&rft.spage=11796&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Fibers; Magnetic fields; Cortex; Magnetic resonance imaging; Noise; Brain; Magnetic susceptibility; Substantia alba; Iron; Substantia grisea ER - TY - JOUR T1 - Enhanced antibody production in mice to the malaria antigen AMA1 by CPG 7909 requires physical association of CpG and antigen AN - 20301264; 7640864 AB - CpG oligodeoxynucleotides are potent immunostimulants. In this study, CPG 7909 was formulated with the recombinant Plasmodium falciparum protein AMA1-C1 adsorbed to Alhydrogel (aluminum hydroxide) and used to immunize mice. Mice receiving free CPG 7909 in a separate same site injection to the AMA1-C1/Alhydrogel had the same antibody responses as mice receiving AMA1-C1/Alhydrogel alone. For mice immunized with CPG 7909 bound to the AMA1-C1/Alhydrogel formulation, there was a bell shaped CPG 7909 dose-response curve with the highest antibody response co-incident with the concentration of CPG 7909 that saturated binding to the Alhydrogel. At a higher CPG 7909 dose where 74% was unbound, there was no enhancement of response over AMA1-C1/Alhydrogel alone. Our results suggest that the adjuvant effects of CpGs are optimal when adsorbed to Alhydrogel and highlight the need for careful characterization of the vaccine formulation. JF - Vaccine AU - Mullen, Gregory E D AU - Aebig, Joan A AU - Dobrescu, Gelu AU - Rausch, Kelly AU - Lambert, Lynn AU - Long, Carole A AU - Miles, Aaron P AU - Saul, Allan AD - Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Rockville, MD 20852, USA, jaebig@niaid.nih.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 5343 EP - 5347 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 25 IS - 29 SN - 0264-410X, 0264-410X KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Aluminum hydroxide KW - Malaria KW - Adjuvants KW - Oligonucleotides KW - Immunostimulants KW - Antibody response KW - CpG islands KW - Plasmodium falciparum KW - Vaccines KW - K 03350:Immunology KW - F 06905:Vaccines KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20301264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Enhanced+antibody+production+in+mice+to+the+malaria+antigen+AMA1+by+CPG+7909+requires+physical+association+of+CpG+and+antigen&rft.au=Mullen%2C+Gregory+E+D%3BAebig%2C+Joan+A%3BDobrescu%2C+Gelu%3BRausch%2C+Kelly%3BLambert%2C+Lynn%3BLong%2C+Carole+A%3BMiles%2C+Aaron+P%3BSaul%2C+Allan&rft.aulast=Mullen&rft.aufirst=Gregory+E&rft.date=2007-07-01&rft.volume=25&rft.issue=29&rft.spage=5343&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2007.05.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Plasmodium falciparum; CpG islands; Vaccines; Aluminum hydroxide; Oligonucleotides; Malaria; Antibody response; Immunostimulants; Adjuvants DO - http://dx.doi.org/10.1016/j.vaccine.2007.05.007 ER - TY - JOUR T1 - PorA Variable Antigenic Regions VR1, VR2, and VR3 of Neisseria meningitidis Serogroups B and C Isolated in Brazil from 1999 to 2004 AN - 20264384; 7462164 AB - The high genetic diversity found among the PorA regions VR1 and VR2 of 101 Neisseria meningitidis isolates from patients with meningococcal disease and healthy carriers in Brazil contrasts with the stability found in the PorA VR3 of these isolates. The presence of VR3 epitope variant 35 or 36 on the surfaces of 87% of the strains analyzed suggests that these antigens should be considered for inclusion in new formulations of vaccines against serogroup B meningococci in Brazil. JF - Infection and Immunity AU - de Filippis, Ivano AU - de Andrade, Claudia Ferreira AU - Silva, Luciete AU - Prevots, DRebecca AU - Vicente, Ana Carolina P AD - National Institute for Quality Control of Health, Oswaldo Cruz Foundation, Rio de Janeiro 21045-900, Brazil. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892. Leonidas and Maria Deane Research Center, Oswaldo Cruz Foundation, 69057-070 Manaus, Brazil. Genetics Department, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21045-900, Brazil Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 3683 EP - 3685 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 7 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - meningococcal disease KW - Brazil KW - Genetic diversity KW - Neisseria meningitidis KW - Vaccines KW - Epitopes KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20264384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=PorA+Variable+Antigenic+Regions+VR1%2C+VR2%2C+and+VR3+of+Neisseria+meningitidis+Serogroups+B+and+C+Isolated+in+Brazil+from+1999+to+2004&rft.au=de+Filippis%2C+Ivano%3Bde+Andrade%2C+Claudia+Ferreira%3BSilva%2C+Luciete%3BPrevots%2C+DRebecca%3BVicente%2C+Ana+Carolina+P&rft.aulast=de+Filippis&rft.aufirst=Ivano&rft.date=2007-07-01&rft.volume=75&rft.issue=7&rft.spage=3683&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - meningococcal disease; Genetic diversity; Vaccines; Epitopes; Neisseria meningitidis; Brazil ER - TY - JOUR T1 - Silencing of genes in cultured Drosophila neurons by RNA interference AN - 20143318; 7560323 AB - Cultures of neuroblasts that generate abundant neurons were established from Drosophila embryos to study silencing of genes by RNA interference (RNAi). Cultured cells expressed ELAV, a marker of neurons, Futsch, a marker of neurites, and Synapsin, Synaptobrevin, and Synaptogamin, proteins involved in neurotransmitter secretion. Conditions were found for efficient transfection of cells with siRNAs for ELAV or the insulin-like receptor, which resulted in marked decreases in neurons that express ELAV and Futsch. Cells also were successfully transfected with long-chain Sox-Neuro dsRNA resulting in a 55% reduction of neurons expressing Futsch. The results suggest that this cultured neural cell system can be used to study RNAi-dependent silencing of genes involved in many kinds of neural functions. JF - Proceedings of the National Academy of Sciences, USA AU - Sharma, Shail K AU - Nirenberg, Marshall AD - Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 12925 EP - 12930 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 31 SN - 0027-8424, 0027-8424 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Entomology Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Synapsin KW - Synaptobrevin KW - Secretion KW - Double-stranded RNA KW - Cell culture KW - Neurogenesis KW - siRNA KW - Transfection KW - Neurons KW - RNA-mediated interference KW - Embryos KW - Axons KW - Neurotransmitters KW - Drosophila KW - Neuroblasts KW - Gene silencing KW - W 30905:Medical Applications KW - N3 11007:Neurobiology KW - Z 05360:Genetics and Evolution KW - N 14830:RNA KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20143318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Silencing+of+genes+in+cultured+Drosophila+neurons+by+RNA+interference&rft.au=Sharma%2C+Shail+K%3BNirenberg%2C+Marshall&rft.aulast=Sharma&rft.aufirst=Shail&rft.date=2007-07-01&rft.volume=104&rft.issue=31&rft.spage=12925&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Synapsin; Synaptobrevin; Double-stranded RNA; Secretion; Cell culture; Neurogenesis; siRNA; Transfection; Neurons; RNA-mediated interference; Axons; Embryos; Neurotransmitters; Neuroblasts; Gene silencing; Drosophila ER - TY - JOUR T1 - Quantitative Assessment of the p53-Mdm2 Feedback Loop Using Protein Lysate Microarrays AN - 20097413; 7529314 AB - Mathematical simulations of the p53-Mdm2 feedback loop suggest that both proteins will exhibit impulsive expression characteristics in response to high cellular stress levels. However, little quantitative experimental evaluation has been done, particularly of the phosphorylated forms. To evaluate the mathematical models experimentally, we used lysate microarrays from an isogenic pair of gamma -ray-irradiated cell lysates from HCT116 (p53 super(+/+) and p53 super(-/-)). Both p53 and Mdm2 proteins showed expected pulses in the wild type, whereas no pulses were seen in the knockout. Based on experimental observations, we determined model parameters and generated an in silico "knockout," reflecting the experimental data, including phosphorylated proteins. [Cancer Res 2007; 67(13):6247-52] JF - Cancer Research AU - Ramalingam, Sundhar AU - Honkanen, Peter AU - Young, Lynn AU - Shimura, Tsutomu AU - Austin, John AU - Steeg, Patricia S AU - Nishizuka, Satoshi AD - Molecular Therapeutics Program, Laboratory of Molecular Pharmacology, National Cancer Institute, and Center for Information Technology, NIH, Bethesda, Maryland Y1 - 2007/07/01/ PY - 2007 DA - 2007 Jul 01 SP - 6247 EP - 6252 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 67 IS - 13 SN - 0008-5472, 0008-5472 KW - Biotechnology and Bioengineering Abstracts; Oncogenes & Growth Factors Abstracts KW - MDM2 protein KW - Mathematical models KW - Data processing KW - Protein arrays KW - Stress KW - Feedback KW - Cancer KW - p53 protein KW - B 26670:Tumor Suppressors KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20097413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Quantitative+Assessment+of+the+p53-Mdm2+Feedback+Loop+Using+Protein+Lysate+Microarrays&rft.au=Ramalingam%2C+Sundhar%3BHonkanen%2C+Peter%3BYoung%2C+Lynn%3BShimura%2C+Tsutomu%3BAustin%2C+John%3BSteeg%2C+Patricia+S%3BNishizuka%2C+Satoshi&rft.aulast=Ramalingam&rft.aufirst=Sundhar&rft.date=2007-07-01&rft.volume=67&rft.issue=13&rft.spage=6247&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - MDM2 protein; Data processing; Mathematical models; Protein arrays; Stress; Feedback; Cancer; p53 protein ER - TY - JOUR T1 - GEOquery: a bridge between the Gene Expression Omnibus (GEO) and BioConductor AN - 20004274; 7555187 AB - Microarray technology has become a standard molecular biology tool. Experimental data have been generated on a huge number of organisms, tissue types, treatment conditions and disease states. The Gene Expression Omnibus (Barrett et al., 2005), developed by the National Center for Bioinformatics (NCBI) at the National Institutes of Health is a repository of nearly 140 000 gene expression experiments. The BioConductor project (Gentleman et al., 2004) is an open-source and open-development software project built in the R statistical programming environment (R Development core Team, 2005) for the analysis and comprehension of genomic data. The tools contained in the BioConductor project represent many state-of-the-art methods for the analysis of microarray and genomics data. We have developed a software tool that allows access to the wealth of information within GEO directly from BioConductor, eliminating many the formatting and parsing problems that have made such analyses labor-intensive in the past. The software, called GEOquery, effectively establishes a bridge between GEO and BioConductor. Easy access to GEO data from BioConductor will likely lead to new analyses of GEO data using novel and rigorous statistical and bioinformatic tools. Facilitating analyses and meta-analyses of microarray data will increase the efficiency with which biologically important conclusions can be drawn from published genomic data. AVAILABILITY: GEOquery is available as part of the BioConductor project. JF - Bioinformatics AU - Sean, Davis AU - Meltzer, Paul S AD - Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, sdavis2@mail.nih.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 1846 EP - 1847 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 23 IS - 14 SN - 1367-4803, 1367-4803 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Computer programs KW - software KW - Statistics KW - Data processing KW - Reviews KW - Bioinformatics KW - genomics KW - G 07730:Development & Cell Cycle KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20004274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=GEOquery%3A+a+bridge+between+the+Gene+Expression+Omnibus+%28GEO%29+and+BioConductor&rft.au=Sean%2C+Davis%3BMeltzer%2C+Paul+S&rft.aulast=Sean&rft.aufirst=Davis&rft.date=2007-07-01&rft.volume=23&rft.issue=14&rft.spage=1846&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gene expression; Computer programs; software; Data processing; Statistics; Reviews; genomics; Bioinformatics ER - TY - JOUR T1 - Circulating Connective Tissue Precursors: Extreme Rarity in Humans and Chondrogenic Potential in Guinea Pigs AN - 19980497; 7533738 AB - Using a variety of cell separation techniques and cultivation conditions, circulating, adherent, connective tissue, clonogenic cells were found in just 3 donors out of 66, demonstrating that these precursors are extremely rare in postnatal human blood. Contrary to humans, guinea pig blood shows much more reproducible connective tissue colony formation; it was therefore chosen to study the differentiation potential of adherent blood-derived clonogenic cells. Out of 22 single colony-derived strains of various morphologies, only 5 spindle-shaped strains showed extensive proliferative capacity in vitro. None of these strains formed bone upon in vivo transplantation, whereas two strains formed cartilage in high-density pellet cultures in vitro. Both chondrogenic strains included cells expressing aggrecan, whereas nonchondrogenic strains did not. Out of four polyclonal strains studied, one formed both cartilage and abundant bone accompanied by hematopoiesis-supporting stroma. Evidently, there are cells in adult guinea pig blood capable of both extensive proliferation and differentiation toward cartilage: circulating chondrogenic precursors. Although some of these cells lack osteogenic potential and therefore represent committed chondrogenic precursors, others may be multipotential and consequently belong to the family of skeletal stem cells. This is the first demonstration of postnatal circulating chondrogenic precursors, as well as of precursor cells with chondrogenic but not osteogenic potential. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Kuznetsov, Sergei A AU - Mankani, Mahesh H AU - Leet, Arabella I AU - Ziran, Navid AU - Gronthos, Stan AU - Robey, Pamela Gehron AD - Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 1830 EP - 1839 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 25 IS - 7 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Stroma KW - Donors KW - Connective tissues KW - Cartilage KW - Cell culture KW - Bone KW - Differentiation KW - Blood KW - Colonies KW - Stem cells KW - Hemopoiesis KW - Cell proliferation KW - aggrecan KW - Separation techniques KW - T 2030:Cartilage and Cartilage Diseases KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19980497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Circulating+Connective+Tissue+Precursors%3A+Extreme+Rarity+in+Humans+and+Chondrogenic+Potential+in+Guinea+Pigs&rft.au=Kuznetsov%2C+Sergei+A%3BMankani%2C+Mahesh+H%3BLeet%2C+Arabella+I%3BZiran%2C+Navid%3BGronthos%2C+Stan%3BRobey%2C+Pamela+Gehron&rft.aulast=Kuznetsov&rft.aufirst=Sergei&rft.date=2007-07-01&rft.volume=25&rft.issue=7&rft.spage=1830&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Stroma; Donors; Connective tissues; Cartilage; Cell culture; Bone; Blood; Differentiation; Stem cells; Colonies; Hemopoiesis; aggrecan; Cell proliferation; Separation techniques ER - TY - JOUR T1 - Global gene expression profiling reveals similarities and differences among mouse pluripotent stem cells of different origins and strains AN - 19947202; 7574195 AB - Pluripotent stem cell lines with similar phenotypes can be derived from both blastocysts (embryonic stem cells, ESC) and primordial germ cells (embryonic germ cells, EGC). Here, we present a compendium DNA microarray analysis of multiple mouse ESCs and EGCs from different genetic backgrounds (strains 129 and C57BL/6) cultured under standard conditions and in differentiation-promoting conditions by the withdrawal of Leukemia Inhibitory Factor (LIF) or treatment with retinoic acid (RA). All pluripotent cell lines showed similar gene expression patterns, which separated them clearly from other tissue stem cells with lower developmental potency. Differences between pluripotent lines derived from different sources (ESC vs. EGC) were smaller than differences between lines derived from different mouse strains (129 vs. C57BL/6). Even in the differentiation-promoting conditions, these pluripotent cells showed the same general trends of gene expression changes regardless of their origin and genetic background. These data indicate that ESCs and EGCs are indistinguishable based on global gene expression patterns alone. On the other hand, a detailed comparison between a group of ESC lines and a group of EGC lines identified 20 signature genes whose average expression levels were consistently higher in ESC lines, and 84 signature genes whose average expression levels were consistently higher in EGC lines, irrespective of mouse strains. Similar analysis identified 250 signature genes whose average expression levels were consistently higher in a group of 129 cell lines, and 337 signature genes whose average expression levels were consistently higher in a group of C57BL/6 cell lines. Although none of the genes was exclusively expressed in either ESCs versus EGCs or 129 versus C57BL/6, in combination these signature genes provide a reliable separation and identification of each cell type. Differentiation-promoting conditions also revealed some minor differences between the cell lines. For example, in the presence of RA, EGCs showed a lower expression of muscle- and cardiac-related genes and a higher expression of gonad-related genes than ESCs. Taken together, the results provide a rich source of information about the similarities and differences between ESCs and EGCs as well as 129 lines and C57BL/6 lines. Such information will be crucial to our understanding of pluripotent stem cells. The results also underscore the importance of studying multiple cell lines from different strains when making comparisons based on gene expression analysis. JF - Developmental Biology AU - Sharova, Lioudmila V AU - Sharov, Alexei A AU - Piao, Yulan AU - Shaik, Nabeebi AU - Sullivan, Terry AU - Stewart, Colin L AU - Hogan, Brigid L M AU - Ko, Minoru S H AD - Laboratory of Genetics, National Institute on Aging, NIH, 333 Cassell Drive, Suite 3000, Baltimore, MD 21224, USA, kom@mail.nih.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 446 EP - 459 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 307 IS - 2 SN - 0012-1606, 0012-1606 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Microarray KW - Gene expression KW - Embryonic stem cells KW - Embryonic germ cells KW - LIF KW - Retinoic acid KW - Differentiation KW - ES cells KW - EG cells KW - Mouse strains KW - C57BL/6 mouse KW - 129 mouse KW - Pluripotency KW - Stem cells KW - blastocysts KW - Data processing KW - Embryo cells KW - Leukemia inhibitory factor KW - Germ cells KW - DNA microarrays KW - W 30910:Imaging KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19947202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+Biology&rft.atitle=Global+gene+expression+profiling+reveals+similarities+and+differences+among+mouse+pluripotent+stem+cells+of+different+origins+and+strains&rft.au=Sharova%2C+Lioudmila+V%3BSharov%2C+Alexei+A%3BPiao%2C+Yulan%3BShaik%2C+Nabeebi%3BSullivan%2C+Terry%3BStewart%2C+Colin+L%3BHogan%2C+Brigid+L+M%3BKo%2C+Minoru+S+H&rft.aulast=Sharova&rft.aufirst=Lioudmila&rft.date=2007-07-01&rft.volume=307&rft.issue=2&rft.spage=446&rft.isbn=&rft.btitle=&rft.title=Developmental+Biology&rft.issn=00121606&rft_id=info:doi/10.1016%2Fj.ydbio.2007.05.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gene expression; blastocysts; Stem cells; Data processing; Embryo cells; Retinoic acid; Leukemia inhibitory factor; Germ cells; DNA microarrays DO - http://dx.doi.org/10.1016/j.ydbio.2007.05.004 ER - TY - JOUR T1 - Genetic linkage and association analyses for trait mapping in Plasmodium falciparum AN - 19890248; 7474905 AB - Genetic studies of Plasmodium falciparum laboratory crosses and field isolates have produced valuable insights into determinants of drug responses, antigenic variation, disease virulence, cellular development and population structures of these virulent human malaria parasites. Full-genome sequences and high-resolution haplotype maps of SNPs and microsatellites are now available for all 14 parasite chromosomes. Rapidly increasing genetic and genomic information on Plasmodium parasites, mosquitoes and humans will combine as a rich resource for new advances in our understanding of malaria, its transmission and its manifestations of disease. JF - Nature Reviews: Genetics AU - Su, Xinzhuan AU - Hayton, Karen AU - Wellems, Thomas E AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike Bethesda, Maryland 20892-8132, USA., twellems@niaid.nih.gov Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 497 EP - 506 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com] VL - 8 IS - 7 SN - 1471-0056, 1471-0056 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biochemistry Abstracts 2: Nucleic Acids; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Genetics Abstracts KW - Parasites KW - Association analysis KW - Human diseases KW - Nucleotide sequence KW - Microsatellites KW - Drug development KW - Malaria KW - Plasmodium falciparum KW - Genotypes KW - Public health KW - Disease transmission KW - Virulence KW - Haplotypes KW - Single-nucleotide polymorphism KW - DNA KW - Population structure KW - genomics KW - Aquatic insects KW - Gene mapping KW - G 07790:Other Microorganisms KW - Q1 08484:Species interactions: parasites and diseases KW - N 14845:Miscellaneous KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19890248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Genetics&rft.atitle=Genetic+linkage+and+association+analyses+for+trait+mapping+in+Plasmodium+falciparum&rft.au=Su%2C+Xinzhuan%3BHayton%2C+Karen%3BWellems%2C+Thomas+E&rft.aulast=Su&rft.aufirst=Xinzhuan&rft.date=2007-07-01&rft.volume=8&rft.issue=7&rft.spage=497&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Genetics&rft.issn=14710056&rft_id=info:doi/10.1038%2Fnrg2126 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Parasites; Human diseases; Nucleotide sequence; DNA; Malaria; Genotypes; Aquatic insects; Disease transmission; Public health; Virulence; Association analysis; Haplotypes; Single-nucleotide polymorphism; Microsatellites; Population structure; Drug development; genomics; Gene mapping; Plasmodium falciparum DO - http://dx.doi.org/10.1038/nrg2126 ER - TY - JOUR T1 - Zscan4: A novel gene expressed exclusively in late 2-cell embryos and embryonic stem cells AN - 19875347; 7574200 AB - The first wave of transcription, called zygotic genome activation (ZGA), begins during the 2-cell stage in mouse preimplantation development and marks a vital transition from the maternal genetic to the embryonic genetic program. Utilizing DNA microarray data, we looked for genes that are expressed only during ZGA and found Zscan4, whose expression is restricted to late 2-cell stage embryos. Sequence analysis of genomic DNA and cDNA clones revealed nine paralogous genes tightly clustered in 0.85 Mb on mouse chromosome 7. Three genes are not transcribed and are thus considered pseudogenes. Among the six expressed genes named Zscan4a-Zscan4f, three - Zscan4c, Zscan4d, and Zscan4f - encode full-length ORFs with 506 amino acids. Zscan4d is a predominant transcript at the late 2-cell stage, whereas Zscan4c is a predominant transcript in embryonic stem (ES) cells. No transcripts of any Zscan4 genes are detected in any other cell types. Reduction of Zscan4 transcript levels by siRNAs delays the progression from the 2-cell to the 4-cell stage and produces blastocysts that fail to implant or proliferate in blastocyst outgrowth culture. Zscan4 thus seems to be essential for preimplantation development. JF - Developmental Biology AU - Falco, Geppino AU - Lee, Sung-Lim AU - Stanghellini, Ilaria AU - Bassey, Uwem C AU - Hamatani, Toshio AU - Ko, Minoru S H AD - Developmental Genomics and Aging Section, Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA, kom@mail.nih.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 539 EP - 550 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 307 IS - 2 SN - 0012-1606, 0012-1606 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Preimplantation embryos KW - ES cells KW - Expression profiling KW - Zygotic genome activation KW - Stage-specific gene expression KW - Paralogs KW - Mouse genome KW - Genomes KW - Pseudogenes KW - Amino acids KW - Data processing KW - Nucleotide sequence KW - Transcription KW - Cell culture KW - DNA microarrays KW - chromosome 7 KW - blastocysts KW - Stem cells KW - Embryogenesis KW - siRNA KW - Embryo cells KW - Waves KW - genomics KW - W 30910:Imaging KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19875347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+Biology&rft.atitle=Zscan4%3A+A+novel+gene+expressed+exclusively+in+late+2-cell+embryos+and+embryonic+stem+cells&rft.au=Falco%2C+Geppino%3BLee%2C+Sung-Lim%3BStanghellini%2C+Ilaria%3BBassey%2C+Uwem+C%3BHamatani%2C+Toshio%3BKo%2C+Minoru+S+H&rft.aulast=Falco&rft.aufirst=Geppino&rft.date=2007-07-01&rft.volume=307&rft.issue=2&rft.spage=539&rft.isbn=&rft.btitle=&rft.title=Developmental+Biology&rft.issn=00121606&rft_id=info:doi/10.1016%2Fj.ydbio.2007.05.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; Pseudogenes; Data processing; Amino acids; Nucleotide sequence; Transcription; Cell culture; DNA microarrays; chromosome 7; Embryogenesis; Stem cells; blastocysts; Embryo cells; siRNA; Waves; genomics DO - http://dx.doi.org/10.1016/j.ydbio.2007.05.003 ER - TY - JOUR T1 - Aberrant DNA methylation and gene expression in livers of newborn mice transplacentally exposed to a hepatocarcinogenic dose of inorganic arsenic AN - 19871418; 7499755 AB - Our prior work showed that brief exposure of pregnant C3H mice to inorganic arsenic-induced hepatocellular carcinoma (HCC) formation in adult male offspring. The current study examined the early hepatic events associated with this oncogenic transformation. Pregnant mice were exposed to a known carcinogenic dose of arsenic (85ppm) in the drinking water from gestation days 8 to 18. The dams were allowed to give birth and liver samples from newborn males were analyzed for arsenic content, global DNA methylation and aberrant expression of genes relevant to the carcinogenic process. Arsenic content in newborn liver reached 57ng/g wet weight, indicating arsenic had crossed the placenta, reached the fetal liver and that significant amounts remained after birth. Global methylation status of hepatic DNA was not altered by arsenic in the newborn. However, a significant reduction in methylation occurred globally in GC-rich regions. Microarray and real-time RT-PCR analysis showed that arsenic exposure enhanced expression of genes encoding for glutathione production and caused aberrant expression of genes related to insulin growth factor signaling pathways and cytochrome P450 enzymes. Other expression alterations observed in the arsenic-treated male mouse newborn liver included the overexpression of cdk-inhibitors and stress response genes including increased expression of metallothionein-1 and decreased expression of betaine-homocysteine methyltransferase and thioether S-methyltransferase. Thus, transplacental exposure to arsenic at a hepatocarcinogenic dose induces alterations in DNA methylation and a complex set of aberrant gene expressions in the newborn liver, a target of arsenic carcinogenesis. JF - Toxicology AU - Xie, Y AU - Liu, J AU - Benbrahim-Tallaa, L AU - Ward, J M AU - Logsdon, D AU - Diwan, BA AU - Waalkes, M P AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, NC, United States, Waalkes@niehs.nih.gov Y1 - 2007/07/01/ PY - 2007 DA - 2007 Jul 01 SP - 7 EP - 15 PB - Elsevier Science Ireland Ltd., P.O. Box 85 Limerick Ireland VL - 236 IS - 1-2 SN - 0300-483X, 0300-483X KW - Genetics Abstracts; Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Transformation KW - Glutathione KW - Insulin KW - Gene expression KW - Thioether S-methyltransferase KW - Placenta KW - Gestation KW - DNA methylation KW - Polymerase chain reaction KW - Growth factors KW - Hepatocellular carcinoma KW - Arsenic KW - Stress KW - Enzymes KW - Fetuses KW - Pregnancy KW - Birth KW - Betaine-homocysteine S-methyltransferase KW - Carcinogenesis KW - Neonates KW - Cytochrome P450 KW - Drinking water KW - Genetic crosses KW - Signal transduction KW - N 14820:DNA Metabolism & Structure KW - X 24360:Metals KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19871418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Aberrant+DNA+methylation+and+gene+expression+in+livers+of+newborn+mice+transplacentally+exposed+to+a+hepatocarcinogenic+dose+of+inorganic+arsenic&rft.au=Xie%2C+Y%3BLiu%2C+J%3BBenbrahim-Tallaa%2C+L%3BWard%2C+J+M%3BLogsdon%2C+D%3BDiwan%2C+BA%3BWaalkes%2C+M+P&rft.aulast=Xie&rft.aufirst=Y&rft.date=2007-07-01&rft.volume=236&rft.issue=1-2&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2007.03.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Transformation; Arsenic; Glutathione; Enzymes; Stress; Fetuses; Insulin; Pregnancy; Gene expression; Birth; Betaine-homocysteine S-methyltransferase; Thioether S-methyltransferase; Placenta; Gestation; Carcinogenesis; DNA methylation; Polymerase chain reaction; Growth factors; Cytochrome P450; Neonates; Drinking water; Genetic crosses; Hepatocellular carcinoma; Signal transduction DO - http://dx.doi.org/10.1016/j.tox.2007.03.021 ER - TY - JOUR T1 - The Late Dividing Population of gamma -Retroviral Vector Transduced Human Mobilized Peripheral Blood Progenitor Cells Contributes Most to Gene-Marked Cell Engraftment in Nonobese Diabetic/Severe Combined Immunodeficient Mice AN - 19864444; 7533735 AB - We used the nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse model to assess the repopulation potential of subpopulations of mobilized human CD34+ peripheral blood progenitor cells (PBPC). First, PBPC were transduced with gamma -retrovirus vector RD114-MFGS-CFP, which requires cell division for successful transduction, at 24 hours, 48 hours, and 72 hours to achieve 96% cyan fluorescent protein (CFP)-positive cells. Cells were sorted 12 hours after the last transduction into CFP-positive (divided cells) and CFP-negative populations. CFP-positive cells were transplanted postsort, whereas the CFP-negative cells were retransduced and injected at 120 hours. The CFP-negative sorted and retransduced cells contained markedly fewer vector copies and resulted in a 32-fold higher overall engraftment and in a 13-fold higher number of engrafted transgene positive cells. To assess cell proliferation as an underlying cause for the different engraftment levels, carboxyfluorescein succinimidyl ester-labeling of untransduced PBPC was performed to track the number of cell divisions. At 72 hours after initiation of culture, when 95% of all cells have divided, PBPC were sorted into nondivided and divided fractions and transplanted into NOD/SCID mice. Nondivided cells demonstrated 45-fold higher engraftment than divided cells. Late dividing PBPC in ex vivo culture retain high expression of the stem cell marker CD133, whereas rapidly proliferating cells lose CD133 in correlation to the number of cell divisions. Our studies demonstrate that late dividing progenitors transduced with gamma -retroviral vectors contribute most to NOD/SCID engraftment and transgene marking. Confining the gamma -retroviral transduction to CD133-positive cells on days 3 and 4 could greatly reduce the number of transplanted vector copies, limiting the risk of leukemia from insertional mutagenesis. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Brenner, Sebastian AU - Ryser, Martin F AU - Whiting-Theobald, Narda L AU - Gentsch, Marcus AU - Linton, Gilda F AU - Malech, Harry L AD - Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. Department of Pediatrics, University Clinic Carl Gustav Carus, Dresden, Germany Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 1807 EP - 1813 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 25 IS - 7 SN - 1066-5099, 1066-5099 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Immunodeficiency KW - Animal models KW - Peripheral blood KW - Cell culture KW - CD34 antigen KW - Diabetes mellitus KW - Leukemia KW - Stem cells KW - Cell division KW - insertional mutagenesis KW - Hemopoiesis KW - Cell proliferation KW - W 30905:Medical Applications KW - V 22410:Animal Diseases KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19864444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pensions+%26+Investment+Age&rft.atitle=Slowdown+in+Fund+Interest+Is+Felt+by+Real+Estate+Sellers&rft.au=Westerbeck%2C+Mark&rft.aulast=Westerbeck&rft.aufirst=Mark&rft.date=1982-08-02&rft.volume=10&rft.issue=16&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Pensions+%26+Investment+Age&rft.issn=02735466&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Leukemia; Cell division; Stem cells; insertional mutagenesis; Animal models; Immunodeficiency; Hemopoiesis; CD34 antigen; Cell culture; Peripheral blood; Cell proliferation ER - TY - JOUR T1 - DAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists AN - 19863420; 7532605 AB - All tools in the DAVID Bioinformatics Resources aim to provide functional interpretation of large lists of genes derived from genomic studies. The newly updated DAVID Bioinformatics Resources consists of the DAVID Knowledgebase and five integrated, web-based functional annotation tool suites: the DAVID Gene Functional Classification Tool, the DAVID Functional Annotation Tool, the DAVID Gene ID Conversion Tool, the DAVID Gene Name Viewer and the DAVID NIAID Pathogen Genome Browser. The expanded DAVID Knowledgebase now integrates almost all major and well-known public bioinformatics resources centralized by the DAVID Gene Concept, a single-linkage method to agglomerate tens of millions of diverse gene/protein identifiers and annotation terms from a variety of public bioinformatics databases. For any uploaded gene list, the DAVID Resources now provides not only the typical gene-term enrichment analysis, but also new tools and functions that allow users to condense large gene lists into gene functional groups, convert between gene/protein identifiers, visualize many-genes-to-many-terms relationships, cluster redundant and heterogeneous terms into groups, search for interesting and related genes or terms, dynamically view genes from their lists on bio-pathways and more. With DAVID (http://david.niaid.nih.gov), investigators gain more power to interpret the biological mechanisms associated with large gene lists. JF - Nucleic Acids Research AU - Huang, Da Wei AU - Sherman, Brad T AU - Tan, Qina AU - Kir, Joseph AU - Liu, David AU - Bryant, David AU - Guo, Yongjian AU - Stephens, Robert AU - Baseler, Michael W AU - Lane, HClifford AU - Lempicki, Richard A AD - Laboratory of Immunopathogenesis and Bioinformatics, Advanced Biomedical Computing Center, Clinical Services Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, MD 21702, USA, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA, Bioinformatics and Scientific IT Program, NIAID Office of Technology Information Systems, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - W169 EP - W175 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 35 SN - 0305-1048, 0305-1048 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Genomes KW - Databases KW - double prime Id protein KW - Algorithms KW - Proteins KW - Bioinformatics KW - Pathogens KW - genomics KW - G 07880:Human Genetics KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19863420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=DAVID+Bioinformatics+Resources%3A+expanded+annotation+database+and+novel+algorithms+to+better+extract+biology+from+large+gene+lists&rft.au=Huang%2C+Da+Wei%3BSherman%2C+Brad+T%3BTan%2C+Qina%3BKir%2C+Joseph%3BLiu%2C+David%3BBryant%2C+David%3BGuo%2C+Yongjian%3BStephens%2C+Robert%3BBaseler%2C+Michael+W%3BLane%2C+HClifford%3BLempicki%2C+Richard+A&rft.aulast=Huang&rft.aufirst=Da&rft.date=2007-07-01&rft.volume=35&rft.issue=&rft.spage=W169&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; double prime Id protein; Databases; Algorithms; Proteins; genomics; Pathogens; Bioinformatics ER - TY - JOUR T1 - PfGCN5-Mediated Histone H3 Acetylation Plays a Key Role in Gene Expression in Plasmodium falciparum AN - 19862090; 7530129 AB - Histone acetylation, regulated by the opposing actions of histone acetyltransferases (HATs) and deacetylases, is an important epigenetic mechanism in eukaryotic transcription. Although an acetyltransferase (PfGCN5) has been shown to preferentially acetylate histone H3 at K9 and K14 in Plasmodium falciparum, the scale of histone acetylation in the parasite genome and its role in transcriptional activation are essentially unknown. Using chromatin immunoprecipitation (ChIP) and DNA microarray, we mapped the global distribution of PfGCN5, histone H3K9 acetylation (H3K9ac) and trimethylation (H3K9m3) in the P. falciparum genome. While the chromosomal distributions of H3K9ac and PfGCN5 were similar, they are radically different from that of H3K9m3. In addition, there was a positive, though weak correlation between relative occupancy of H3K9ac on individual genes and the levels of gene expression, which was inversely proportional to the distance of array elements from the putative translational start codons. In contrast, H3K9m3 was negatively correlated with gene expression. Furthermore, detailed mapping of H3K9ac for selected genes using ChIP and real-time PCR in three erythrocytic stages detected stage-specific peak H3K9ac enrichment at the putative transcriptional initiation sites, corresponding to stage-specific expression of these genes. These data are consistent with H3K9ac and H3K9m3 as epigenetic markers of active and silent genes, respectively. We also showed that treatment with a PfGCN5 inhibitor led to reduced promoter H3K9ac and gene expression. Collectively, these results suggest that PfGCN5 is recruited to the promoter regions of genes to mediate histone acetylation and activate gene expression in P. falciparum. JF - Eukaryotic Cell AU - Cui, Long AU - Miao, Jun AU - Furuya, Tetsuya AU - Li, Xinyi AU - Su, Xin-zhuan AU - Cui, Liwang AD - Department of Entomology, The Pennsylvania State University, University Park, Pennsylvania 16802. Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2007/07// PY - 2007 DA - July 2007 SP - 1219 EP - 1227 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA VL - 6 IS - 7 SN - 1535-9778, 1535-9778 KW - Genetics Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology; Biochemistry Abstracts 2: Nucleic Acids KW - Genomes KW - Translation KW - Parasites KW - Human diseases KW - Chromatin KW - Histone acetyltransferase KW - Nucleotide sequence KW - DNA microarrays KW - Transcription initiation KW - Public health KW - Gene expression KW - Promoters KW - Chromosomes KW - Acetyltransferase KW - epigenetics KW - Polymerase chain reaction KW - Histone H3 KW - Data processing KW - Immunoprecipitation KW - Transcription KW - Plasmodium falciparum KW - Acetylation KW - Codons KW - DNA KW - Methylation KW - Transcription activation KW - Gene mapping KW - N 14820:DNA Metabolism & Structure KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03310:Genetics & Taxonomy KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19862090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eukaryotic+Cell&rft.atitle=PfGCN5-Mediated+Histone+H3+Acetylation+Plays+a+Key+Role+in+Gene+Expression+in+Plasmodium+falciparum&rft.au=Cui%2C+Long%3BMiao%2C+Jun%3BFuruya%2C+Tetsuya%3BLi%2C+Xinyi%3BSu%2C+Xin-zhuan%3BCui%2C+Liwang&rft.aulast=Cui&rft.aufirst=Long&rft.date=2007-07-01&rft.volume=6&rft.issue=7&rft.spage=1219&rft.isbn=&rft.btitle=&rft.title=Eukaryotic+Cell&rft.issn=15359778&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Gene expression; Parasites; Human diseases; Chromosomes; Nucleotide sequence; Immunoprecipitation; DNA; Public health; Genomes; Translation; Data processing; Chromatin; Histone acetyltransferase; Transcription; DNA microarrays; Transcription initiation; Acetylation; Promoters; Acetyltransferase; epigenetics; Codons; Polymerase chain reaction; Histone H3; Methylation; Transcription activation; Gene mapping; Plasmodium falciparum ER - TY - JOUR T1 - Crystallographic studies of the complexes of antiviral protein griffithsin with glucose and N-acetylglucosamine AN - 19854012; 7464926 AB - Crystal structures of complexes of an antiviral lectin griffithsin (GRFT) with glucose and N-acetylglucosamine were solved and refined at high resolution. In both complexes, all six monosaccharide-binding sites of GRFT were occupied and the mode of binding was similar to that of mannose. In our previous attempts to obtain a complex with N-acetylglucosamine by soaking, only a single site was occupied; thus, cocrystallization was clearly superior despite lower concentration of the ligand. Isothermal titration calorimetric experiments with N-acetylglucosamine, glucose, and mannose provided enthalpic evidence of distinct binding differences between the three monosaccharides. A comparison of the mode of binding of different monosaccharides is discussed in the context of the antiviral activity of GRFT, based on specific binding to high-mannose-containing complex carbohydrates found on viral envelopes. JF - Protein Science AU - Ziolkowska, Natasza E AU - Shenoy, Shilpa R AU - O'Keefe, Barry R AU - Wlodawer, Alexander AD - Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, NCI-Frederick, Frederick, Maryland 21702-1201, USA. Molecular Targets Development Program, SAIC-Frederick, Inc., National Cancer Institute, NCI-Frederick, Frederick, Maryland 21702-1201, USA. Molecular Targets Development Program, Center for Cancer Research, National Cancer Institute, NCI-Frederick, Frederick, Maryland 21702-1201, USA Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 1485 EP - 1489 PB - Cold Spring Harbor Laboratory Press, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 16 IS - 7 SN - 0961-8368, 0961-8368 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Envelopes KW - Mannose KW - Titration KW - Glucose KW - Crystal structure KW - Lectins KW - N-Acetylglucosamine KW - monosaccharides KW - Carbohydrates KW - Antiviral activity KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19854012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Science&rft.atitle=Crystallographic+studies+of+the+complexes+of+antiviral+protein+griffithsin+with+glucose+and+N-acetylglucosamine&rft.au=Ziolkowska%2C+Natasza+E%3BShenoy%2C+Shilpa+R%3BO%27Keefe%2C+Barry+R%3BWlodawer%2C+Alexander&rft.aulast=Ziolkowska&rft.aufirst=Natasza&rft.date=2007-07-01&rft.volume=16&rft.issue=7&rft.spage=1485&rft.isbn=&rft.btitle=&rft.title=Protein+Science&rft.issn=09618368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Envelopes; Mannose; Titration; Crystal structure; Glucose; Lectins; Carbohydrates; monosaccharides; N-Acetylglucosamine; Antiviral activity ER - TY - JOUR T1 - A Mechanistic Approach for Modulation of Arsenic Toxicity in Human Lymphocytes by Curcumin, an Active Constituent of Medicinal Herb Curcuma longa Linn AN - 19784128; 7534428 AB - Chronic exposure of humans to high concentrations of arsenic in drinking water is associated with skin lesions, peripheral vascular disease, hypertension, blackfoot disease and a high risk of cancer. Arsenic induces single strand breaks, DNA-protein crosslinks and apurinic sites in DNA, which are prerequisites for induction of cancer. Amelioration of such damages with natural compounds could be an effective strategy to combat arsenic toxicity. Curcumin is the active ingredient of turmeric, a common household spice, which is a rich source of polyphenols and this compound has been extensively studied as a chemopreventive agent against many types of cancer. The present study investigates whether curcumin could counteract the DNA damage caused by arsenic as assessed by single cell gel electrophoresis (SCGE) using peripheral blood lymphocytes, from healthy donors. It was observed that DNA damage induced by arsenic could be efficiently reduced by curcumin and the effect was more pronounced when lymphocytes were pre-incubated with curcumin prior to arsenic insult Arsenic caused DNA damage by generation of reactive oxygen species (ROS) and enhancement of lipid peroxidation levels. Curcumin counteracted the damage by quenching ROS, decreasing the level of lipid peroxidation and increasing the level of phase II detoxification enzymes like catalase, superoxide dismutase and glutathione peroxidase. Curcumin also enhanced the DNA repair activity against arsenic induced damage. The expression of polymerase, a repair enzyme, was found to be highly elevated when arsenite induced damaged cells were allowed to repair in presence of curcumin. Results indicate that curcumin has significant role in confronting the deleterious effect caused by arsenic, which could be an economic mode of arsenic mitigation among rural population in West Bengal, India. JF - Journal of Clinical Biochemistry and Nutrition AU - Mukherjee, S AU - Roy, M AU - Dey, S AU - Bhattacharya, R K AD - Department of Environmental Carcinogenesis & Toxicology, Chittaranjan National Cancer Institute, 37 S.P. Mukherjee Road, Kolkata 700 026, India, rathin_b2001@yahoo.co.in Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 32 EP - 42 VL - 41 IS - 1 SN - 0912-0009, 0912-0009 KW - Pollution Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts; Toxicology Abstracts KW - herbs KW - Vascular diseases KW - India, West Bengal KW - Glutathione peroxidase KW - Chronic exposure KW - Economics KW - chemopreventive agents KW - Apurinic sites KW - vascular diseases KW - Curcumin KW - Blackfoot disease KW - Spices KW - Peripheral blood KW - peroxidation KW - Oxygen KW - hypertension KW - Hypertension KW - Detoxification KW - Lipids KW - Lymphocytes KW - mitigation KW - households KW - Reactive oxygen species KW - Superoxide dismutase KW - Risk factors KW - Herbal medicines KW - Arsenic KW - Electrophoresis KW - Polyphenols KW - Arsenite KW - Enzymes KW - Rural populations KW - Toxicity KW - DNA repair KW - Cancer KW - Lipid peroxidation KW - Catalase KW - DNA damage KW - Skin diseases KW - Curcuma longa KW - DNA KW - Drinking water KW - Rural areas KW - F 06955:Immunomodulation & Immunopharmacology KW - P 2000:FRESHWATER POLLUTION KW - N 14820:DNA Metabolism & Structure KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19784128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Biochemistry+and+Nutrition&rft.atitle=A+Mechanistic+Approach+for+Modulation+of+Arsenic+Toxicity+in+Human+Lymphocytes+by+Curcumin%2C+an+Active+Constituent+of+Medicinal+Herb+Curcuma+longa+Linn&rft.au=Mukherjee%2C+S%3BRoy%2C+M%3BDey%2C+S%3BBhattacharya%2C+R+K&rft.aulast=Mukherjee&rft.aufirst=S&rft.date=2007-07-01&rft.volume=41&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Biochemistry+and+Nutrition&rft.issn=09120009&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Detoxification; Lymphocytes; Vascular diseases; Reactive oxygen species; Chronic exposure; Superoxide dismutase; Glutathione peroxidase; Risk factors; Economics; Herbal medicines; chemopreventive agents; Apurinic sites; Arsenic; Curcumin; Polyphenols; Spices; Blackfoot disease; Arsenite; Rural populations; Enzymes; Peripheral blood; Toxicity; DNA repair; Catalase; Lipid peroxidation; Cancer; DNA damage; Skin diseases; Drinking water; Hypertension; vascular diseases; Electrophoresis; herbs; Lipids; peroxidation; Oxygen; households; mitigation; hypertension; DNA; Rural areas; Curcuma longa; India, West Bengal ER - TY - JOUR T1 - Systematic analysis of genetic alterations in tumors using Cancer Genome WorkBench (CGWB) AN - 19780393; 7530182 AB - Systematic investigations of genetic changes in tumors are expected to lead to greatly improved understanding of cancer etiology. To meet the analytical challenges presented by such studies, we developed the Cancer Genome WorkBench (http://cgwb.nci.nih.gov), the first computational platform to integrate clinical tumor mutation profiles with the reference human genome. A novel heuristic algorithm, IndelDetector, was developed to automatically identify insertion/deletion (indel) polymorphisms as well as indel somatic mutations with high sensitivity and accuracy. It was incorporated into an automated pipeline that detects genetic alterations and annotates their effects on protein coding and 3D structure. The ability of the system to facilitate identifying genetic alterations is illustrated in three projects with publicly accessible data. Mutagenesis in tumor DNA replication leading to complex genetic changes in the EGFR kinase domain is suggested by a novel deletion-insertion combination observed in paired tumor-normal lung cancer resequencing data. Automated analysis of 152 genes resequenced by the SeattleSNPs group was able to identify 91% of the 1251 indel polymorphisms discovered by SeattleSNPs. In addition, our system discovered 518 novel indels in this data set, 451 of which were found to be valid by manual inspection of sequence traces. Our experience demonstrates that CGWB not only greatly improves the productivity and the accuracy of mutation identification, but also, through its data integration and visualization capabilities, facilitates identification of underlying genetic etiology. JF - Genome Research AU - Zhang, Jinghui AU - Finney, Richard P AU - Rowe, William AU - Edmonson, Michael AU - Yang, Sei Hoon AU - Dracheva, Tatiana AU - Jen, Jin AU - Struewing, Jeffery P AU - Buetow, Kenneth H AD - Laboratory of Population Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Wonkwang University Hospital, Cheonbuk 570-749, Korea Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 1111 EP - 1117 PB - Cold Spring Harbor Laboratory Press, Fulfillment & Distribution Dept. 500 Sunnyside Boulevard Woodbury NY 11797-2924 USA, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 17 IS - 7 SN - 1088-9051, 1088-9051 KW - Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Genomes KW - DNA biosynthesis KW - Deletion KW - Etiology KW - Data processing KW - Replication KW - Gene polymorphism KW - Algorithms KW - Epidermal growth factor receptors KW - Tumors KW - Computer applications KW - Mutagenesis KW - Integration KW - Insertion KW - Problem solving KW - Mutation KW - Lung cancer KW - N 14820:DNA Metabolism & Structure KW - W 30960:Bioinformatics & Computer Applications KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19780393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genome+Research&rft.atitle=Systematic+analysis+of+genetic+alterations+in+tumors+using+Cancer+Genome+WorkBench+%28CGWB%29&rft.au=Zhang%2C+Jinghui%3BFinney%2C+Richard+P%3BRowe%2C+William%3BEdmonson%2C+Michael%3BYang%2C+Sei+Hoon%3BDracheva%2C+Tatiana%3BJen%2C+Jin%3BStruewing%2C+Jeffery+P%3BBuetow%2C+Kenneth+H&rft.aulast=Zhang&rft.aufirst=Jinghui&rft.date=2007-07-01&rft.volume=17&rft.issue=7&rft.spage=1111&rft.isbn=&rft.btitle=&rft.title=Genome+Research&rft.issn=10889051&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; DNA biosynthesis; Etiology; Deletion; Data processing; Replication; Gene polymorphism; Algorithms; Epidermal growth factor receptors; Tumors; Computer applications; Mutagenesis; Integration; Insertion; Problem solving; Mutation; Lung cancer ER - TY - JOUR T1 - Protein recognition motifs: Design of peptidomimetics of helix surfaces AN - 19766948; 7586135 AB - Helices represent one of the most common recognition motifs in proteins. The design of nonpeptidic scaffolds, such as the 3,2,2-tris-substituted terphenyl, that can imitate the side-chain orientation along one face of an -helix potentially provides an effective means to modulate helix-recognition functions. Here, based on theoretical arguments, we described novel -helix mimetics which are more effective than the terphenyl at constraining the aryl-aryl torsion angles to those associated with structures suitable for mimicking the -helical twist for side-chain orientation and for superimposing the side chains of residues i, i + 3 or i + 4, i + 7 when compared with the - side-chain vectors of the regular -helix with an improved root mean square deviation (RMSD) of approximately 0.5 A. In addition, this study suggests that rotamer distributions around the CC bonds of these helix mimetics are similar to those of -helices, except that these rotamer distributions show an approximately 60° shift compared to those of -helices when the mimetic axis is superimposed upon the helix axis. This change in rotamer orientation complicates mimicry of the helix surface. JF - Biopolymers AU - Che, Ye AU - Brooks, Bernard R AU - Marshall, Garland R AD - Laboratory of Computational Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, chey@nhlbi.nih.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 288 EP - 297 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 86 IS - 4 SN - 0006-3525, 0006-3525 KW - Biotechnology and Bioengineering Abstracts KW - Mimicry KW - peptidomimetics KW - Biopolymers KW - scaffolds KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19766948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biopolymers&rft.atitle=Protein+recognition+motifs%3A+Design+of+peptidomimetics+of+helix+surfaces&rft.au=Che%2C+Ye%3BBrooks%2C+Bernard+R%3BMarshall%2C+Garland+R&rft.aulast=Che&rft.aufirst=Ye&rft.date=2007-07-01&rft.volume=86&rft.issue=4&rft.spage=288&rft.isbn=&rft.btitle=&rft.title=Biopolymers&rft.issn=00063525&rft_id=info:doi/10.1002%2Fbip.20744 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Mimicry; peptidomimetics; Biopolymers; scaffolds DO - http://dx.doi.org/10.1002/bip.20744 ER - TY - JOUR T1 - Cancer Vaccines: Moving Beyond Current Paradigms AN - 19747642; 7529666 AB - The field of cancer vaccines is currently in an active state of preclinical and clinical investigations. Although no therapeutic cancer vaccine has to date been approved by the Food and Drug Administration, several new paradigms are emerging from recent clinical findings both in the use of combination therapy approaches and, perhaps more importantly, in clinical trial design and end point analyses. This article will review recent clinical trials involving several different cancer vaccines from which data are emerging contrasting classic "tumor response" (Response Evaluation Criteria in Solid Tumors) criteria with "patient response" in the manifestation of increased patient survival post-vaccine therapy. Also described are several strategies in which cancer vaccines can be exploited in combination with other agents and therapeutic modalities that are quite unique when compared with "conventional" combination therapies. This is most likely due to the phenomena that (a) cancer vaccines initiate a dynamic immune process that can be exploited in subsequent therapies and (b) both radiation and certain chemotherapeutic agents have been shown to alter the phenotype of tumor cells as to render them more susceptible to T-cell-mediated killing. Consequently, evidence is emerging from several studies in which patient cohorts who first receive a cancer vaccine (as contrasted with control cohorts) benefit clinically from subsequent therapies. JF - Clinical Cancer Research AU - Schlom, Jeffrey AU - Arlen, Philip M AU - Gulley, James L AD - Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2007/07/01/ PY - 2007 DA - 2007 Jul 01 SP - 3776 EP - 3782 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 13 IS - 13 SN - 1078-0432, 1078-0432 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Cancer vaccines KW - Solid tumors KW - Chemotherapy KW - Survival KW - Drug development KW - Tumors KW - Tumor cells KW - Clinical trials KW - b Radiation KW - ^b Radiation KW - Reviews KW - Lymphocytes T KW - F 06915:Cancer Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19747642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Cancer+Vaccines%3A+Moving+Beyond+Current+Paradigms&rft.au=Schlom%2C+Jeffrey%3BArlen%2C+Philip+M%3BGulley%2C+James+L&rft.aulast=Schlom&rft.aufirst=Jeffrey&rft.date=2007-07-01&rft.volume=13&rft.issue=13&rft.spage=3776&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Cancer vaccines; Drug development; Clinical trials; Survival; Reviews; Tumors; Tumor cells; b Radiation; Lymphocytes T; Chemotherapy; Solid tumors; ^b Radiation ER - TY - JOUR T1 - Commentary: Engineering of Tissue Healing and Regeneration AN - 19735821; 7543063 AB - Regenerative medicine aims to restore homeostasis of diseased tissues and organs. With time, engineered replacement tissue constructs will play an increasingly important role in achieving this goal. Equally important, however, will be the ability to resolve disease-associated inflammation and to optimize tissue regenerative capacity by specifically patterning the host tissue microenvironment. The tools of bioen-gineering are uniquely suited to meet these challenges. Here, the candidate molecular and cellular targets for manipulating the host's inflammatory environment and tissue regenerative capacity are briefly discussed within the context of current and emerging bioengineering strategies. The objective is to draw the attention of basic scientists and engineers to the importance of regulating inflammation in achieving the goals of tissue engineering and regenerative medicine. JF - Tissue Engineering AU - Lumelsky, N L AD - National Institute of Dental and Craniofacial Research, National Institutes of Health, 45 Center Drive, Bldg. 45, Room 4An.18J, Bethesda, MD 20892, USA, nadyal@nidcr.nih.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 1393 EP - 1398 VL - 13 IS - 7 SN - 1076-3279, 1076-3279 KW - Biotechnology and Bioengineering Abstracts KW - Microenvironments KW - Homeostasis KW - Tissue engineering KW - Pattern formation KW - Alternation learning KW - Inflammation KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19735821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering&rft.atitle=Commentary%3A+Engineering+of+Tissue+Healing+and+Regeneration&rft.au=Lumelsky%2C+N+L&rft.aulast=Lumelsky&rft.aufirst=N&rft.date=2007-07-01&rft.volume=13&rft.issue=7&rft.spage=1393&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering&rft.issn=10763279&rft_id=info:doi/10.1089%2Ften.2007.0100 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Microenvironments; Homeostasis; Tissue engineering; Alternation learning; Pattern formation; Inflammation DO - http://dx.doi.org/10.1089/ten.2007.0100 ER - TY - JOUR T1 - Quality Control and Reference Guidelines for CLSI Broth Microdilution Method (M38-A Document) for Susceptibility Testing of Anidulafungin against Molds AN - 19730816; 7531471 AB - The CLSI (formerly NCCLS) M38-A document for antifungal susceptibility testing of filamentous fungi does not describe guidelines for echinocandins. A multicenter study (eight centers) evaluated inter- and intralaboratory reproducibilities of two reading times (24 and 48 h or 48 and 72 h) and two end points (MICs and minimum effective concentrations [MECs]) for evaluating anidulafungin against molds. Anidulafungin MICs ( greater than or equal to 50% inhibition) and MECs (morphological hyphal changes) were determined for seven Aspergillus isolates (four species) and one isolate each of Fusarium moniliforme, Fusarium solani, and Paecilomyces variotii and for two Scedosporium apiospermum isolates. The inter- and intralaboratory reproducibilities of 10 replicate tests performed in each laboratory on 10 different days for each isolate was 100% at 24 h (MECs, less than or equal to 0.015 mu g/ml) for six Aspergillus and P. variotii isolates. The reproducibility was 94 to 96.7% at 72 h (MECs, 1 to 8 mu g/ml) for S. apiospermum and 96.7 to 97.5% at 48 h (MICs, greater than or equal to 32 mu g/ml) for both Fusarium isolates. Introduction of these identified optimum testing conditions for anidulafungin into future versions of the M38 document is warranted. JF - Journal of Clinical Microbiology AU - Espinel-Ingroff, A AU - Fothergill, A AU - Ghannoum, M AU - Manavathu, E AU - Ostrosky-Zeichner, L AU - Pfaller, MA AU - Rinaldi, M G AU - Schell, W AU - Walsh, T J AD - VCU Medical Center, Richmond, Virginia. University of Texas Health Science Center, San Antonio, Texas. Case Western Reserve University, Cleveland, Ohio. Wayne State University, Detroit, Michigan. University of Texas-Houston Medical School, Houston, Texas. University of Iowa College of Medicine, Iowa City, Iowa. Duke University, Durham, North Carolina. National Cancer Institute, Bethesda, Maryland Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 2180 EP - 2182 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 45 IS - 7 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Fusarium moniliforme KW - Scedosporium apiospermum KW - Quality control KW - Molds KW - Aspergillus KW - Paecilomyces variotii KW - echinocandins KW - Minimum inhibitory concentration KW - Fusarium solani KW - K 03300:Methods KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19730816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Quality+Control+and+Reference+Guidelines+for+CLSI+Broth+Microdilution+Method+%28M38-A+Document%29+for+Susceptibility+Testing+of+Anidulafungin+against+Molds&rft.au=Espinel-Ingroff%2C+A%3BFothergill%2C+A%3BGhannoum%2C+M%3BManavathu%2C+E%3BOstrosky-Zeichner%2C+L%3BPfaller%2C+MA%3BRinaldi%2C+M+G%3BSchell%2C+W%3BWalsh%2C+T+J&rft.aulast=Espinel-Ingroff&rft.aufirst=A&rft.date=2007-07-01&rft.volume=45&rft.issue=7&rft.spage=2180&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Quality control; Molds; echinocandins; Minimum inhibitory concentration; Fusarium moniliforme; Scedosporium apiospermum; Paecilomyces variotii; Aspergillus; Fusarium solani ER - TY - JOUR T1 - Transcription Activation by the DNA-Binding Domain of the AraC Family Protein RhaS in the Absence of Its Effector-Binding Domain AN - 19729672; 7530823 AB - The Escherichia coli L-rhamnose-responsive transcription activators RhaS and RhaR both consist of two domains, a C-terminal DNA-binding domain and an N-terminal dimerization domain. Both function as dimers and only activate transcription in the presence of L-rhamnose. Here, we examined the ability of the DNA-binding domains of RhaS (RhaS-CTD) and RhaR (RhaR-CTD) to bind to DNA and activate transcription. RhaS-CTD and RhaR-CTD were both shown by DNase I footprinting to be capable of binding specifically to the appropriate DNA sites. In vivo as well as in vitro transcription assays showed that RhaS-CTD could activate transcription to high levels, whereas RhaR-CTD was capable of only very low levels of transcription activation. As expected, RhaS-CTD did not require the presence of L-rhamnose to activate transcription. The upstream half-site at rhaBAD and the downstream half-site at rhaT were found to be the strongest of the known RhaS half-sites, and a new putative RhaS half-site with comparable strength to known sites was identified. Given that cyclic AMP receptor protein (CRP), the second activator required for full rhaBAD expression, cannot activate rhaBAD expression in a Delta rhaS strain, it was of interest to test whether CRP could activate transcription in combination with RhaS-CTD. We found that RhaS-CTD allowed significant activation by CRP, both in vivo and in vitro, although full-length RhaS allowed somewhat greater CRP activation. We conclude that RhaS-CTD contains all of the determinants necessary for transcription activation by RhaS. JF - Journal of Bacteriology AU - Wickstrum, Jason R AU - Skredenske, Jeff M AU - Kolin, Ana AU - Jin, Ding J AU - Fang, Jianwen AU - Egan, Susan M AD - Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045. Transcription Control Section, Gene Regulation and Chromosome Biology Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Bldg. 469, P.O. Box B, Frederick, Maryland 21702. Bioinformatics Core Facility, University of Kansas, Lawrence, Kansas 66045 Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 4984 EP - 4993 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 189 IS - 14 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Footprinting KW - Transcription factors KW - L-Rhamnose KW - Escherichia coli KW - DNA KW - Deoxyribonuclease KW - Cyclic AMP receptor protein KW - J 02310:Genetics & Taxonomy KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19729672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Transcription+Activation+by+the+DNA-Binding+Domain+of+the+AraC+Family+Protein+RhaS+in+the+Absence+of+Its+Effector-Binding+Domain&rft.au=Wickstrum%2C+Jason+R%3BSkredenske%2C+Jeff+M%3BKolin%2C+Ana%3BJin%2C+Ding+J%3BFang%2C+Jianwen%3BEgan%2C+Susan+M&rft.aulast=Wickstrum&rft.aufirst=Jason&rft.date=2007-07-01&rft.volume=189&rft.issue=14&rft.spage=4984&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Footprinting; Transcription factors; L-Rhamnose; DNA; Cyclic AMP receptor protein; Deoxyribonuclease; Escherichia coli ER - TY - JOUR T1 - Organisms Designated as Nocardia asteroides Drug Pattern Type VI Are Members of the Species Nocardia cyriacigeorgica AN - 19728639; 7531482 AB - Nocardia cyriacigeorgica has recently been described as an "emerging" pathogen. However, DNA-DNA hybridization results confirm that Nocardia asteroides drug pattern type VI, which has long been recognized as a common and significant pathogen in the United States, belongs to the species N. cyriacigeorgica. JF - Journal of Clinical Microbiology AU - Conville, Patricia S AU - Witebsky, Frank G AD - Microbiology Service, Department of Laboratory Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, U.S. Department of Health and Human Services, 10 Center Drive, MSC 1508, Bethesda, Maryland 20892-1508 Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 2257 EP - 2259 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 45 IS - 7 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Pathogens KW - Drugs KW - Nocardia asteroides KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19728639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Organisms+Designated+as+Nocardia+asteroides+Drug+Pattern+Type+VI+Are+Members+of+the+Species+Nocardia+cyriacigeorgica&rft.au=Conville%2C+Patricia+S%3BWitebsky%2C+Frank+G&rft.aulast=Conville&rft.aufirst=Patricia&rft.date=2007-07-01&rft.volume=45&rft.issue=7&rft.spage=2257&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Pathogens; Drugs; Nocardia asteroides ER - TY - JOUR T1 - Clinical research with economically disadvantaged populations AN - 19728631; 7532391 AB - Concerns about exploiting the poor or economically disadvantaged in clinical research are widespread in the bioethics community. For some, any research that involves economically disadvantaged individuals is de facto ethically problematic. The economically disadvantaged are thought of as "venerable" to exploitation, impaired decision making, or both, thus requiring either special protections or complete exclusion from research. A closer examination of the worries about vulnerabilities among the economically disadvantaged reveals that some of these worries are empirically or logically untenable, while others can be better resolved by improved study designs than by blanket exclusion of poorer individuals from research participation. The scientific objective to generate generalisable results and the ethical objective to fairly distribute both the risks and benefits of research oblige researchers not to unnecessarily bar economically disadvantaged subjects from clinical research participation. JF - Journal of Medical Ethics AU - Denny, Colleen C AU - Grady, Christine AD - Department of Clinical Bioethics, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 382 EP - 385 PB - British Medical Association, BMA House Square Tavistock Square London WC1H 9JP UK, [mailto:info.web@bma.org.uk], [URL:http://www.bma.org.uk/] VL - 33 IS - 7 SN - 0306-6800, 0306-6800 KW - Risk Abstracts KW - Ethics KW - Socioeconomics KW - vulnerability KW - Clinical trials KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19728631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Ethics&rft.atitle=Clinical+research+with+economically+disadvantaged+populations&rft.au=Denny%2C+Colleen+C%3BGrady%2C+Christine&rft.aulast=Denny&rft.aufirst=Colleen&rft.date=2007-07-01&rft.volume=33&rft.issue=7&rft.spage=382&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Ethics&rft.issn=03066800&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Ethics; Socioeconomics; vulnerability; Clinical trials ER - TY - JOUR T1 - Weekend and Weekday Patterns of Physical Activity in Overweight and Normal-weight Adolescent Girls AN - 19727052; 7532899 AB - OBJECTIVE: To describe the patterns (specifically comparing weekdays and weekends classified by intensities) of physical activity (PA) measured by accelerometry in adolescent girls. RESEARCH METHODS AND PROCEDURES: Healthy sixth grade girls (n = 1603), 11 to 12 years old, were randomly recruited from 36 schools participating in the Trial of Activity in Adolescent Girls. Age, ethnicity, socioeconomic status, weight, and height were taken. PA patterns were measured for 6 days using accelerometry. RESULTS: Adolescent girls spend most of their time in sedentary (52% to 57% of the day) and light activity (40% to 45% of the day) on weekdays and weekends. In all girls, total PA comprised 44.5% of the day (41.7% light, 2.2% moderate, and 0.7% vigorous) with sedentary activity comprising 55.4%. Moderate-to-vigorous PA (MVPA) was higher (p < 0.001) on weekdays than weekends in all girls, but MVPA was lower in at-risk of overweight + overweight girls (p < 0.001) on both weekdays and weekends compared with normal-weight girls. DISCUSSION: Adolescent girls are more active at moderate and vigorous intensities on weekdays than on weekends, and at-risk of overweight and those overweight spend less time engaging in MVPA than normal-weight girls. JF - Obesity Research AU - Treuth, Margarita S AU - Catellier, Diane J AU - Schmitz, Kathryn H AU - Pate, Russell R AU - Elder, John P AU - McMurray, Robert G AU - Blew, Robert M AU - Yang, Song AU - Webber, Larry AD - Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. Biostatistics and. Exercise and Sport Sciences, University of North Carolina, Chapel Hill, North Carolina. Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania. Department of Exercise Science, University of South Carolina, Columbia, South Carolina. Graduate School of Public Health, San Diego State University, San Diego, California. Department of Physiology, University of Arizona, Tucson, Arizona. National Heart, Lung, and Blood Institute, Bethesda, Maryland. Department of Biostatistics, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 1782 EP - 1788 PB - North American Association for the Study of Obesity, 1090 Amsterdam Ave., Ste. 14K New York NY 10025 USA, [mailto:helener@mindspring.com], [URL:http://www.naaso.org] VL - 15 IS - 7 SN - 1071-7323, 1071-7323 KW - Physical Education Index KW - Obesity KW - Measurement KW - Socioeconomic factors KW - Schools KW - Weight KW - Girls KW - Adolescence KW - Height KW - Health KW - Exercise KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19727052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obesity+Research&rft.atitle=Weekend+and+Weekday+Patterns+of+Physical+Activity+in+Overweight+and+Normal-weight+Adolescent+Girls&rft.au=Treuth%2C+Margarita+S%3BCatellier%2C+Diane+J%3BSchmitz%2C+Kathryn+H%3BPate%2C+Russell+R%3BElder%2C+John+P%3BMcMurray%2C+Robert+G%3BBlew%2C+Robert+M%3BYang%2C+Song%3BWebber%2C+Larry&rft.aulast=Treuth&rft.aufirst=Margarita&rft.date=2007-07-01&rft.volume=15&rft.issue=7&rft.spage=1782&rft.isbn=&rft.btitle=&rft.title=Obesity+Research&rft.issn=10717323&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Measurement; Obesity; Socioeconomic factors; Schools; Weight; Adolescence; Girls; Height; Health; Exercise ER - TY - JOUR T1 - Modulation by budesonide of a CpG endonuclease in mouse lung tumors AN - 19724775; 7529426 AB - CpG endonuclease activity was identified in nuclear extracts obtained from mouse lung tumors. Enzyme activity was determined using a 333 bp polymerase chain reaction product of the estrogen receptor- alpha gene that contained either radiolabeled cytosine or tritium-labeled methyl groups at CpG sites. Activity was measured as the release of radioactivity from the substrate. The product of the nuclease activity was identified by high pressure liquid chromatography (HPLC) as either 5-methyl-2'-deoxycytidine when the CpG sites in the substrate were methylated or 2'-deoxycytidine when the CpG sites were not methylated. The CpG endonuclease activity was dependent on nuclear protein and temperature, had a proclivity for double-stranded over single-stranded DNA and was inhibited by ethylenediaminetetraacetic acid or 2-mercaptoethanol. Strain A/J mouse lung tumors induced by vinyl carbamate had a greater level of CpG endonuclease activity than non-involved lung tissue. Budesonide, a potent chemopreventive agent in mouse lung, not only prevented an increase in CpG endonuclease activity in lung tumors but, when administered to mice with established tumors, also decreased the level of endonuclease activity in the tumors. The effect of budesonide on CpG endonuclease activity in lung tumors was inversely related to its published effect on DNA methylation in mouse lung tumors, i.e. the drug decreased CpG endonuclease activity and increased the methylation of DNA. The increased CpG endonuclease activity in mouse lung tumors and its inhibition by budesonide would suggest this endonuclease as a potential molecular target for chemoprevention. JF - Carcinogenesis AU - Li, Long AU - Tao, Lianhui AU - Lubet, Ronald A AU - Steele, Vernon E AU - Pereira, Michael A AD - Department of Biochemistry and Cancer Biology, Medical University of Ohio, 3055 Arlington Avenue, Toledo, OH 43614-5806, USA. Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine, Ohio State University, 1148 CHRI, 300 West 10th Avenue, Columbus, OH 43210-1240, USA. Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA. Present address: Division of Biology, California Institute of Technology, Mail Code 156-29, 1200 East California Boulevard, Pasadena, CA 91125, USA Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 1499 EP - 1503 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 28 IS - 7 SN - 0143-3334, 0143-3334 KW - Biotechnology and Bioengineering Abstracts KW - High-performance liquid chromatography KW - Temperature effects KW - vinyl carbamate KW - budesonide KW - Nuclease KW - Enzymes KW - Single-stranded DNA KW - Tumors KW - CpG islands KW - Cytosine KW - 2-Mercaptoethanol KW - Liquid chromatography KW - Lung KW - Carcinogenesis KW - DNA methylation KW - Polymerase chain reaction KW - chemopreventive agents KW - Radioactivity KW - Pressure KW - Endonuclease KW - Drugs KW - Estrogen receptors KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19724775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Modulation+by+budesonide+of+a+CpG+endonuclease+in+mouse+lung+tumors&rft.au=Li%2C+Long%3BTao%2C+Lianhui%3BLubet%2C+Ronald+A%3BSteele%2C+Vernon+E%3BPereira%2C+Michael+A&rft.aulast=Li&rft.aufirst=Long&rft.date=2007-07-01&rft.volume=28&rft.issue=7&rft.spage=1499&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - CpG islands; Endonuclease; Lung; Tumors; budesonide; DNA methylation; Radioactivity; Enzymes; Liquid chromatography; chemopreventive agents; 2-Mercaptoethanol; Estrogen receptors; Drugs; Temperature effects; Carcinogenesis; Pressure; vinyl carbamate; Cytosine; Polymerase chain reaction; High-performance liquid chromatography; Nuclease; Single-stranded DNA ER - TY - JOUR T1 - Gut flora antigens are not important in the maintenance of regulatory T cell heterogeneity and homeostasis AN - 19719134; 7516041 AB - CD25+ regulatory T cells (Treg) are a heterogeneous population that exists as CD44low and CD44high cells. Here we report that while both CD44low and CD44high Treg are anergic and express similar levels of Foxp3, CD44high Treg are highly proliferative in vivo and are more potent suppressors in vitro than CD44low Treg. From analysis of the properties of Treg derived from germ-free mice, it was concluded that peptide antigens derived from intestinal microorganisms are not essential for the generation, in vivo proliferation or suppressive activity of Treg. Our results suggest that gut flora antigens play little or no role in the heterogeneity and homeostatic regulation of Treg. JF - European Journal of Immunology AU - Min, Booki AU - Thornton, Angela AU - Caucheteux, Stephan M AU - Younes, Souheil-Antoine AU - Oh, Keunhee AU - Hu-Li, Jane AU - Paul, William E AD - Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, minb@ccf.org Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 1916 EP - 1923 PB - Wiley-VCH, Postfach 101161 Weinheim 69451 Germany, [mailto:info@wiley-vch.de], [URL:http://www.wiley-vch.de/publish/en/] VL - 37 IS - 7 SN - 0014-2980, 0014-2980 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Immunoregulation KW - Digestive tract KW - Foxp3 protein KW - Lymphocytes T KW - Microorganisms KW - Intestine KW - Gnotobiotics KW - Anergy KW - Homeostasis KW - CD25 antigen KW - A 01490:Miscellaneous KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19719134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Immunology&rft.atitle=Gut+flora+antigens+are+not+important+in+the+maintenance+of+regulatory+T+cell+heterogeneity+and+homeostasis&rft.au=Min%2C+Booki%3BThornton%2C+Angela%3BCaucheteux%2C+Stephan+M%3BYounes%2C+Souheil-Antoine%3BOh%2C+Keunhee%3BHu-Li%2C+Jane%3BPaul%2C+William+E&rft.aulast=Min&rft.aufirst=Booki&rft.date=2007-07-01&rft.volume=37&rft.issue=7&rft.spage=1916&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Immunology&rft.issn=00142980&rft_id=info:doi/10.1002%2Feji.200737236 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Immunoregulation; Digestive tract; Foxp3 protein; Gnotobiotics; Intestine; Microorganisms; Lymphocytes T; Anergy; Homeostasis; CD25 antigen DO - http://dx.doi.org/10.1002/eji.200737236 ER - TY - JOUR T1 - Migration of Intradermally Injected Quantum Dots to Sentinel Organs in Mice AN - 19687312; 7465391 AB - Topical exposure to nanoscale materials is likely from a variety of sources including sunscreens and cosmetics. Because the in vivo disposition of nanoscale materials is not well understood, we have evaluated the distribution of quantum dots (QDs) following intradermal injection into female SKH-1 hairless mice as a model system for determining tissue localization following intradermal infiltration. The QD (CdSe core, CdS capped, poly[ethylene glycol] coated, 37 nm diameter, 621 nm fluorescence emission) were injected intradermally (ID) on the right dorsal flank. Within minutes following intradermal injection, the highly UV fluorescent QD could be observed moving from the injection sites apparently through the lymphatic duct system to regional lymph nodes. Residual fluorescent QD remained at the site of injection until necropsy at 24 h. Quantification of cadmium and selenium levels after 0, 4, 8, 12, or 24 h in multiple tissues, using inductively coupled plasma mass spectrometry (ICP-MS), showed a time-dependent loss of cadmium from the injection site, and accumulation in the liver, regional draining lymph nodes, kidney, spleen, and hepatic lymph node. Fluorescence microscopy corroborated the ICP-MS results regarding the tissue distribution of QD. The results indicated that (1) ID injected nanoscale QD remained as a deposit in skin and penetrated the surrounding viable subcutis, (2) QD were distributed to draining lymph nodes through the sc lymphatics and to the liver and other organs, and (3) sentinel organs are effective locations for monitoring transdermal penetration of nanoscale materials into animals. JF - Toxicological Sciences AU - Gopee, Neera V AU - Roberts, Dean W AU - Webb, Peggy AU - Cozart, Christy R AU - Siitonen, Paul H AU - Warbritton, Alan R AU - Yu, William W AU - Colvin, Vicki L AU - Walker, Nigel J AU - Howard, Paul C AD - National Center for Toxicological Research. National Toxicology Program Center for Phototoxicology, U.S. Food and Drug Administration, Jefferson, Arkansas 72079. Toxicology Pathology Associates, Jefferson, Arkansas 72079. Center for Biological and Environmental Nanotechnology and Department of Chemistry, Rice University, Houston, Texas, 77251. National Institute of Environmental Health Sciences, National Institutes of Health, and the National Toxicology Program, Research Triangle Park, North Carolina, 27709 Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 249 EP - 257 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 98 IS - 1 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - Deposits KW - Autopsy KW - Fluorescence KW - Skin KW - Spleen KW - Cosmetics KW - Disposition KW - Mass spectroscopy KW - Lymph nodes KW - Selenium KW - Quantum dots KW - Kidney KW - Liver KW - Sunscreens KW - Cadmium KW - Hairless KW - X 24340:Cosmetics, Toiletries & Household Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19687312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Migration+of+Intradermally+Injected+Quantum+Dots+to+Sentinel+Organs+in+Mice&rft.au=Gopee%2C+Neera+V%3BRoberts%2C+Dean+W%3BWebb%2C+Peggy%3BCozart%2C+Christy+R%3BSiitonen%2C+Paul+H%3BWarbritton%2C+Alan+R%3BYu%2C+William+W%3BColvin%2C+Vicki+L%3BWalker%2C+Nigel+J%3BHoward%2C+Paul+C&rft.aulast=Gopee&rft.aufirst=Neera&rft.date=2007-07-01&rft.volume=98&rft.issue=1&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Autopsy; Deposits; Skin; Fluorescence; Spleen; Disposition; Cosmetics; Lymph nodes; Mass spectroscopy; Selenium; Quantum dots; Liver; Kidney; Sunscreens; Hairless; Cadmium ER - TY - JOUR T1 - Use of respirometer in evaluation of process and toxicity of thermophilic anaerobic digestion for treating kitchen waste AN - 19576131; 7393824 AB - A thermophilic anaerobic digestion (TAnD, 55 not equal to ) system was adopted to hydrolyze the kitchen waste for 3 days, which was then fermented for a hydraulic retention time (HRT) of 10 days. The TAnD system performed much better than a similar system without thermal pre-treatment. A bubble respirometer was employed to study the effects of thermal pre-treatment, which showed that pre-treatment at 60 not equal to yielded the highest Total COD (TCOD) removal efficiency (79.2%) after 300 h reaction. Respirometer results also indicated that oil and grease (O and G) began to inhibit the TAnD system at a concentration of approximately 1000 mg/L and the gas production was inhibited by 50% at a concentration of approximately 7500 mg/L of sodium. JF - Bioresource Technology AU - Kuo, Wen-Chien AU - Cheng, Kae-Yiin AD - Department of Environmental Science and Engineering, National Pingtung University of Science and Technology, 1 Hseuh Fu Road, Nei Pu, Pingtung 91207, Taiwan, xwck@mail.npust.edu.tw Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 1805 EP - 1811 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 98 IS - 9 SN - 0960-8524, 0960-8524 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts KW - Thermophilic anaerobic digestion KW - Kitchen waste KW - Respirometer KW - Oil and grease KW - Sodium toxicity KW - Hydraulics KW - grease KW - Wastes KW - respirometers KW - Waste treatment KW - Chemical oxygen demand KW - Toxicity KW - Anaerobic digestion KW - Kitchens KW - Sodium KW - Oil KW - Gas production KW - W 30950:Waste Treatment & Pollution Clean-up KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19576131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioresource+Technology&rft.atitle=Use+of+respirometer+in+evaluation+of+process+and+toxicity+of+thermophilic+anaerobic+digestion+for+treating+kitchen+waste&rft.au=Kuo%2C+Wen-Chien%3BCheng%2C+Kae-Yiin&rft.aulast=Kuo&rft.aufirst=Wen-Chien&rft.date=2007-07-01&rft.volume=98&rft.issue=9&rft.spage=1805&rft.isbn=&rft.btitle=&rft.title=Bioresource+Technology&rft.issn=09608524&rft_id=info:doi/10.1016%2Fj.biortech.2006.06.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Oil; Sodium; Hydraulics; Gas production; grease; Wastes; Chemical oxygen demand; Toxicity; Anaerobic digestion; Kitchens; respirometers; Waste treatment DO - http://dx.doi.org/10.1016/j.biortech.2006.06.016 ER - TY - JOUR T1 - Monitoring of Larval Habitats and Mosquito Densities in the Sudan Savanna of Mali: Implications for Malaria Vector Control AN - 19298778; 8174395 AB - In Mali, anopheline mosquito populations increase sharply during the rainy season, but are barely detectable in the dry season. This study attempted to identify the dry season mosquito breeding population in and near the village of Bancoumana, Mali, and in a fishing hamlet 5 km from this village and adjacent to the Niger River. In Bancoumana, most larval habitats were human made, and dried out in January-February. In contrast, in the fishing hamlet, productive larval habitats were numerous and found mainly during the dry season (January-May) as the natural result of drying riverbeds. Adult mosquitoes were abundant during the dry season in the fishermen hamlet and rare in Bancoumana. To the extent that the fishermen hamlet mosquito population seeds Bancoumana with the advent of the rainy season, vector control in this small hamlet may be a cost-effective way to ameliorate malaria transmission in the 40-times larger village. JF - American Journal of Tropical Medicine and Hygiene AU - Sogoba, N AU - Doumbia, S AU - Vounatsou, P AU - Baber, I AU - Keita, M AU - Maiga, M AU - Traore, S F AU - Toure, A AU - Dolo, G AU - Smith, T AU - Ribeiro, JMC AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20892-8132, jribeiro@niaid.nih.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 82 EP - 88 VL - 77 IS - 1 SN - 0002-9637, 0002-9637 KW - Mosquitoes KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Entomology Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Rivers KW - Seeds KW - Human diseases KW - Mali KW - Vectors KW - Drying KW - Culicidae KW - Pest control KW - Malaria KW - Hosts KW - Sudan KW - Habitat KW - Public health KW - Disease transmission KW - Fishing KW - Savannahs KW - Breeding KW - Africa, Niger R. KW - Aquatic insects KW - K 03400:Human Diseases KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - Q1 08485:Species interactions: pests and control KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19298778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Monitoring+of+Larval+Habitats+and+Mosquito+Densities+in+the+Sudan+Savanna+of+Mali%3A+Implications+for+Malaria+Vector+Control&rft.au=Sogoba%2C+N%3BDoumbia%2C+S%3BVounatsou%2C+P%3BBaber%2C+I%3BKeita%2C+M%3BMaiga%2C+M%3BTraore%2C+S+F%3BToure%2C+A%3BDolo%2C+G%3BSmith%2C+T%3BRibeiro%2C+JMC&rft.aulast=Sogoba&rft.aufirst=N&rft.date=2007-07-01&rft.volume=77&rft.issue=1&rft.spage=82&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Human diseases; Malaria; Pest control; Hosts; Aquatic insects; Disease transmission; Public health; Rivers; Savannahs; Fishing; Seeds; Breeding; Drying; Vectors; Habitat; Culicidae; Mali; Africa, Niger R.; Sudan ER - TY - JOUR T1 - Absence of full-length Brca1 sensitizes mice to oxidative stress and carcinogen-induced tumorigenesis in the esophagus and forestomach AN - 1492621338; 18956133 AB - Environmental and genetic factors are important both in affecting life span and neoplastic transformation. We have shown previously that mice, which are homozygous for full-length breast cancer-associated gene-1 (Brca1) deletion and heterozygous for a p53-null mutation (Brca1 super( Delta 11/ Delta 11)p53 super(+/-)), display premature aging and high frequency of spontaneous lymphoma and mammary tumor formation. To investigate the role of Brca1 in regulation of organ homeostasis and susceptibility of Brca1 deficiency to environmental carcinogens, we examined biological function of Brca1 in maintaining organ homeostasis and carcinogen-induced tumorigenesis. Brca1 super( Delta 11/ Delta 11)p53 super(+/-) mice showed altered gastrointestinal tract homeostasis, including hyperkeratosis in the esophagus and forestomach. At 6 months of age, most mutant mice displayed hyperplasia in their forestomach and esophagus, leading to dysplasia and carcinoma formation in older animals. Brca1 mutant mice exhibited increased expression of Redd1, elevated reactive oxygen species and are more sensitive to oxidative stress induced lethality. Upon methyl-N-amylnitrosamine (MNAN) treatment, 70% Brca1 mutant mice developed tumors within 4 months whereas only 14% control animals developed tumor at the same period of the time. Our further analysis revealed that the tumorigenesis is accompanied by the loss of p53 and increased expression of a number of oncogenes, including Cyclin D1, phosphorylated form of Akt, beta -catenin, Runx-2 and c-Myc. These results suggest that Brca1 is involved in renewable organ homeostasis, linking the environmental and genetic factors in carcinogenesis and aging, and providing new insights into genomic instability in organism maintenance and tumorigenesis. JF - Carcinogenesis AU - Cao, Liu AU - Xu, Xiaoling AU - Cao, Longyue L AU - Wang, Rui-Hong AU - Coumoul, Xavier AU - Kim, Sang S AU - Deng, Chu-Xia AD - Genetics of Development and Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10/9N105, 10 Center Drive, Bethesda, MD 20892, USA, chuxiad@bdg10.niddk.nih.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 1401 EP - 1407 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 28 IS - 7 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts KW - AKT protein KW - BRCA1 protein KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1492621338?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Absence+of+full-length+Brca1+sensitizes+mice+to+oxidative+stress+and+carcinogen-induced+tumorigenesis+in+the+esophagus+and+forestomach&rft.au=Cao%2C+Liu%3BXu%2C+Xiaoling%3BCao%2C+Longyue+L%3BWang%2C+Rui-Hong%3BCoumoul%2C+Xavier%3BKim%2C+Sang+S%3BDeng%2C+Chu-Xia&rft.aulast=Cao&rft.aufirst=Liu&rft.date=2007-07-01&rft.volume=28&rft.issue=7&rft.spage=1401&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/10.1093%2Fcarcin%2Fbgm060 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-01-01 N1 - Last updated - 2014-02-11 N1 - SubjectsTermNotLitGenreText - BRCA1 protein DO - http://dx.doi.org/10.1093/carcin/bgm060 ER - TY - JOUR T1 - Polymorphisms in immunoregulatory genes, smoky coal exposure and lung cancer risk in Xuan Wei, China AN - 1492621216; 18956138 AB - We conducted a population-based case-control study in Xuan Wei, China, where lung cancer rates are among the highest in China due to exposure to indoor coal combustion products, to evaluate the association between polymorphisms in immunoregulatory genes and lung cancer risk. A total of 122 incident primary lung cancer cases and 122 individually matched controls were enrolled in Xuan Wei, China. Fifty single-nucleotide polymorphisms (SNPs) in 23 immunoregulatory genes involved in inflammation were genotyped and analyzed by logistic regression to assess the risk of lung cancer. A global test of association for 42 SNPs, which excluded eight SNPs that were in very tight linkage disequilibrium with other SNPs, was statistically significant (P = 0.01), suggesting that overall genetic variation in this pathway contributes to lung cancer risk. In addition, the IL1B -1060TT (i.e. -511TT) genotype was associated with increased lung cancer risk compared with the CC genotype [odds ratio (OR) = 2.27, 95% confidence interval (CI) = 1.05-4.91]. The IL8RA Ex2+860 GC or CC (OR = 0.27, 95% CI = 0.11-0.67), ICAM1 Ex2+100 AT or TT (OR = 0.39, 95% CI = 0.18-0.88) and IL12A Ex7+277 GA or AA (OR = 0.43, 95% CI = 0.22-0.84) genotypes were associated with decreased lung cancer risk. The protective effect of the IL8RA variant was stronger among subjects with high cumulative smoky coal use ( greater than or equal to 130 tons) (OR = 0.11, 95% CI = 0.03-0.44; P sub(interaction) = 0.03). In conclusion, genetic variation in immunoregulatory genes may play an important role in the development of lung cancer in this population. JF - Carcinogenesis AU - Lee, Kyoung-Mu AU - Shen, Min AU - Chapman, Robert S AU - Yeager, Meredith AU - Welch, Robert AU - He, Xingzhou AU - Zheng, Tongzhang AU - Hosgood, H Dean AU - Yang, Dongyun AU - Berndt, Sonja I AU - Chanock, Stephen AU - Lan, Qing AD - 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7240, USA, leekyou@mail.nih.gov Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 1437 EP - 1441 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 28 IS - 7 SN - 0143-3334, 0143-3334 KW - Genetics Abstracts; Toxicology Abstracts; Immunology Abstracts KW - Immunoregulation KW - Combustion products KW - Gene polymorphism KW - Interleukin 1 KW - Statistical analysis KW - Genetic diversity KW - Coal KW - Inflammation KW - Guanylate cyclase KW - Linkage disequilibrium KW - Single-nucleotide polymorphism KW - Carcinogenesis KW - intercellular adhesion molecule 1 KW - Lung cancer KW - X 24490:Other KW - F 06915:Cancer Immunology KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1492621216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Polymorphisms+in+immunoregulatory+genes%2C+smoky+coal+exposure+and+lung+cancer+risk+in+Xuan+Wei%2C+China&rft.au=Lee%2C+Kyoung-Mu%3BShen%2C+Min%3BChapman%2C+Robert+S%3BYeager%2C+Meredith%3BWelch%2C+Robert%3BHe%2C+Xingzhou%3BZheng%2C+Tongzhang%3BHosgood%2C+H+Dean%3BYang%2C+Dongyun%3BBerndt%2C+Sonja+I%3BChanock%2C+Stephen%3BLan%2C+Qing&rft.aulast=Lee&rft.aufirst=Kyoung-Mu&rft.date=2007-07-01&rft.volume=28&rft.issue=7&rft.spage=1437&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/10.1093%2Fcarcin%2Fbgm030 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-01-01 N1 - Last updated - 2014-05-15 N1 - SubjectsTermNotLitGenreText - Immunoregulation; Combustion products; Gene polymorphism; Interleukin 1; Statistical analysis; Genetic diversity; Coal; Inflammation; Linkage disequilibrium; Guanylate cyclase; Single-nucleotide polymorphism; intercellular adhesion molecule 1; Carcinogenesis; Lung cancer DO - http://dx.doi.org/10.1093/carcin/bgm030 ER - TY - JOUR T1 - Leukocyte polycyclic aromatic hydrocarbon-DNA adduct formation and colorectal adenoma AN - 1492619765; 18956131 AB - Consumption of charbroiled red meat and meat-derived polycyclic aromatic hydrocarbons (PAHs) has been associated with risk of colorectal adenoma, a precursor of colorectal cancer. Furthermore, leukocyte PAH-DNA adduct levels have been demonstrated to increase in response to charbroiled red meat intake but to date there have been no studies that have investigated the relationship between leukocyte PAH-DNA adduct levels and risk of colorectal adenoma. We investigated the relation of leukocyte PAH-DNA adduct formation and colorectal adenoma in a clinic-based case-control study of colorectal adenomas. The study comprised 82 cases of colorectal adenoma and 111 polyp-free controls, none of whom were current smokers. Leukocyte PAH-DNA adducts were measured by a sensitive chemiluminescence immunoassay using an antiserum elicited against DNA modified with ( plus or minus )-7 beta ,8 alpha -dihydroxy-9 alpha ,10 alpha -epoxy -7,8,9,10-tetrahydro-benzo[a]pyrene that recognizes several PAHs bound to human DNA. Leukocyte PAH-DNA adduct levels were higher among colorectal adenoma cases (median, 1.4 adducts per 10 super(8) nucleotides) than polyp-free controls (median, 1.2 adducts per 10 super(8) nucleotides) (P = 0.02). There was a positive association between PAH-DNA adduct level and adenoma prevalence: each unit increase in PAH-DNA adduct level (per 10 super(8) nucleotides) was associated with an odds ratio (OR) of 1.5 [95% confidence interval (CI), 1.1-2.2]. In addition, a comparison of the lowest quartile for PAH-DNA adduct level with the highest quartile yielded an OR of 2.8 (95% CI, 1.2-6.5; P sub(trend) = 0.048) for risk of colorectal adenoma. These data support a link between PAH exposure and colorectal adenoma. JF - Carcinogenesis AU - Gunter, Marc J AU - Divi, Rao L AU - Kulldorff, Martin AU - Vermeulen, Roel AU - Haverkos, Kathryn J AU - Kuo, Maryanne M AU - Strickland, Paul AU - Poirier, Miriam C AU - Rothman, Nathaniel AU - Sinha, Rashmi AD - 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Division of Health and Human Services, Bethesda, MD 20852, USA, mgunter@aecom.yu.edu Y1 - 2007/07// PY - 2007 DA - Jul 2007 SP - 1426 EP - 1429 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 28 IS - 7 SN - 0143-3334, 0143-3334 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Polycyclic aromatic hydrocarbons KW - Data processing KW - Adducts KW - Leukocytes KW - Colorectal cancer KW - Nucleotides KW - Meat KW - Carcinogenesis KW - DNA KW - Chemiluminescence KW - Immunoassays KW - Adenoma KW - Aromatics KW - N 14840:Antisense, Nucleotide Analogs KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1492619765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Leukocyte+polycyclic+aromatic+hydrocarbon-DNA+adduct+formation+and+colorectal+adenoma&rft.au=Gunter%2C+Marc+J%3BDivi%2C+Rao+L%3BKulldorff%2C+Martin%3BVermeulen%2C+Roel%3BHaverkos%2C+Kathryn+J%3BKuo%2C+Maryanne+M%3BStrickland%2C+Paul%3BPoirier%2C+Miriam+C%3BRothman%2C+Nathaniel%3BSinha%2C+Rashmi&rft.aulast=Gunter&rft.aufirst=Marc&rft.date=2007-07-01&rft.volume=28&rft.issue=7&rft.spage=1426&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/10.1093%2Fcarcin%2Fbgm022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-01-01 N1 - Last updated - 2014-06-12 N1 - SubjectsTermNotLitGenreText - Polycyclic aromatic hydrocarbons; Data processing; Adducts; Leukocytes; Colorectal cancer; Nucleotides; Meat; Carcinogenesis; DNA; Chemiluminescence; Adenoma; Immunoassays; Aromatics DO - http://dx.doi.org/10.1093/carcin/bgm022 ER - TY - JOUR T1 - Formulation of vaccines containing CpG oligonucleotides and alum AN - 20813900; 8241313 AB - CpG oligodeoxynucleotides are potent immunostimulants. For parenterally delivered alum-based vaccines, the immunostimulatory effect of CpG depends on the association of the CpG and antigen to the alum. We describe effects of buffer components on the binding of CPG 7909 to aluminum hydroxide (Alhydrogel), assays for measuring binding of CPG 7909 to alum and CPG 7909 induced dissociation of antigen from the alum. Free CPG 7909 is a potent inducer of IP-10 in mice. However the lack of IP-10 production from formulations containing bound CPG 7909 suggested that CPG 7909 does not rapidly dissociate from the alum after injection. It also suggests that IP-10 assays are not a good basis for potency assays for alum-based vaccines containing CPG 7909. JF - Journal of Immunological Methods AU - Aebig, JA AU - Mullen, GED AU - Dobrescu, G AU - Rausch, K AU - Lambert, L AU - Ajose-Popoola, O AU - Long, CA AU - Saul, A AU - Miles, A P AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Rockville, MD, 20852 USA, jaebig@niaid.nih.gov Y1 - 2007/06/30/ PY - 2007 DA - 2007 Jun 30 SP - 139 EP - 146 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 323 IS - 2 SN - 0022-1759, 0022-1759 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - IP-10 protein KW - Immunostimulation KW - Aluminum hydroxide KW - CpG islands KW - Vaccines KW - Immunostimulants KW - Oligonucleotides KW - F 06900:Methods KW - W 30965:Miscellaneous, Reviews KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20813900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=Formulation+of+vaccines+containing+CpG+oligonucleotides+and+alum&rft.au=Aebig%2C+JA%3BMullen%2C+GED%3BDobrescu%2C+G%3BRausch%2C+K%3BLambert%2C+L%3BAjose-Popoola%2C+O%3BLong%2C+CA%3BSaul%2C+A%3BMiles%2C+A+P&rft.aulast=Aebig&rft.aufirst=JA&rft.date=2007-06-30&rft.volume=323&rft.issue=2&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2007.04.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - IP-10 protein; Immunostimulation; Aluminum hydroxide; Immunostimulants; Vaccines; CpG islands; Oligonucleotides DO - http://dx.doi.org/10.1016/j.jim.2007.04.003 ER - TY - JOUR T1 - Dynamic transcriptional regulatory complexes including BORIS, CTCF and Sp1 modulate NY-ESO-1 expression in lung cancer cells. AN - 70676383; 17260018 AB - Previously, we reported that the paralogous zinc-finger proteins--CTCF and brother of the regulator of imprinted sites (BORIS), directly contribute to transcriptional regulation of NY-ESO-1 in lung cancer cells. To further examine mechanisms that mediate expression of this cancer-testis gene, we performed software-guided analysis of the NY-ESO-1 promoter region, which revealed several potential Sp1-binding motifs. Sequential 5-aza-2'deoxycytidine/depsipeptide FK228 treatment markedly induced BORIS expression and enhanced nuclear translocation of Sp1 in lung cancer cells. Transient transfection assays using promoter-reporter constructs, as well as gel-shift and chromatin immunoprecipitation experiments revealed that NY-ESO-1 promoter activity coincided with occupancy of the proximal Sp1-binding site in lung cancer cells. Mutations within the Sp1 recognition sequence specifically eliminated binding of Sp1 to this motif in vitro, and markedly diminished NY-ESO-1 promoter activity in vivo. siRNA-mediated inhibition of Sp1 expression decreased NY-ESO-1 promoter activity, whereas knock down of CTCF expression augmented NY-ESO-1 transcription in lung cancer cells. Co-immunoprecipitation experiments indicated that Sp1 physically interacts with BORIS but not with CTCF in vivo. Collectively, these findings suggest that BORIS recruits Sp1 to mediate de-repression of NY-ESO-1 during pulmonary carcinogenesis. JF - Oncogene AU - Kang, Y AU - Hong, J A AU - Chen, G A AU - Nguyen, D M AU - Schrump, D S AD - Thoracic Oncology Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-1201, USA. Y1 - 2007/06/28/ PY - 2007 DA - 2007 Jun 28 SP - 4394 EP - 4403 VL - 26 IS - 30 SN - 0950-9232, 0950-9232 KW - Antigens, Neoplasm KW - 0 KW - CCCTC-binding factor KW - CTAG1B protein, human KW - CTCFL protein, human KW - DNA-Binding Proteins KW - Depsipeptides KW - Membrane Proteins KW - Repressor Proteins KW - Sp1 Transcription Factor KW - Index Medicus KW - Promoter Regions, Genetic KW - Base Sequence KW - Humans KW - Depsipeptides -- pharmacology KW - Molecular Sequence Data KW - Cell Line, Tumor KW - Binding Sites KW - Gene Expression Regulation, Neoplastic KW - Sp1 Transcription Factor -- physiology KW - Repressor Proteins -- physiology KW - Antigens, Neoplasm -- analysis KW - DNA-Binding Proteins -- physiology KW - Membrane Proteins -- genetics KW - Membrane Proteins -- analysis KW - Antigens, Neoplasm -- genetics KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70676383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Dynamic+transcriptional+regulatory+complexes+including+BORIS%2C+CTCF+and+Sp1+modulate+NY-ESO-1+expression+in+lung+cancer+cells.&rft.au=Kang%2C+Y%3BHong%2C+J+A%3BChen%2C+G+A%3BNguyen%2C+D+M%3BSchrump%2C+D+S&rft.aulast=Kang&rft.aufirst=Y&rft.date=2007-06-28&rft.volume=26&rft.issue=30&rft.spage=4394&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-02 N1 - Date created - 2007-06-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bidirectional, iterative approach to the structural delineation of the functional "chemoprint" in GPR40 for agonist recognition. AN - 70648405; 17552505 AB - GPR40, free fatty acid receptor 1 (FFAR1), is a member of the GPCR superfamily and a possible target for the treatment of type 2 diabetes. In this work, we conducted a bidirectional iterative investigation, including computational modeling and site-directed mutagenesis, aimed at delineating amino acid residues forming the functional "chemoprint" of GPR40 for agonist recognition. The computational and experimental studies revolved around the recognition of the potent synthetic agonist GW9508. Our experimentally supported model suggested that H137(4.56), R183(5.39), N244(6.55), and R258(7.35) are directly involved in interactions with the ligand. We have proposed a polarized NH-pi interaction between H137(4.56) and GW9508 as one of the contributing forces leading to the high potency of GW9508. The modeling approach presented in this work provides a general strategy for the exploration of receptor-ligand interactions in G-protein coupled receptors beginning prior to acquisition of experimental data. JF - Journal of medicinal chemistry AU - Tikhonova, Irina G AU - Sum, Chi Shing AU - Neumann, Susanne AU - Thomas, Craig J AU - Raaka, Bruce M AU - Costanzi, Stefano AU - Gershengorn, Marvin C AD - Laboratory of Biological Modeling, Clinical Endocrinology Branch, Chemical Biology Core Facility, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2007/06/28/ PY - 2007 DA - 2007 Jun 28 SP - 2981 EP - 2989 VL - 50 IS - 13 SN - 0022-2623, 0022-2623 KW - FFAR1 protein, human KW - 0 KW - GW9508 KW - Ligands KW - Methylamines KW - Propionates KW - Receptors, G-Protein-Coupled KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Humans KW - Propionates -- pharmacology KW - Propionates -- chemistry KW - Binding Sites KW - Sequence Analysis, Protein KW - Calcium -- metabolism KW - Mutagenesis, Site-Directed KW - Methylamines -- chemistry KW - Mutation KW - Cell Line KW - Methylamines -- pharmacology KW - Protein Conformation KW - Receptors, G-Protein-Coupled -- agonists KW - Models, Molecular KW - Receptors, G-Protein-Coupled -- chemistry KW - Receptors, G-Protein-Coupled -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70648405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Bidirectional%2C+iterative+approach+to+the+structural+delineation+of+the+functional+%22chemoprint%22+in+GPR40+for+agonist+recognition.&rft.au=Tikhonova%2C+Irina+G%3BSum%2C+Chi+Shing%3BNeumann%2C+Susanne%3BThomas%2C+Craig+J%3BRaaka%2C+Bruce+M%3BCostanzi%2C+Stefano%3BGershengorn%2C+Marvin+C&rft.aulast=Tikhonova&rft.aufirst=Irina&rft.date=2007-06-28&rft.volume=50&rft.issue=13&rft.spage=2981&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=00222623&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-09-02 N1 - Date created - 2007-06-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2003 Mar 13;422(6928):173-6 [12629551] Mol Pharmacol. 2001 Jul;60(1):1-19 [11408595] J Biol Chem. 2003 Mar 28;278(13):11303-11 [12496284] J Comb Chem. 2003 May-Jun;5(3):233-7 [12739938] Biochem Biophys Res Commun. 2004 Feb 13;314(3):805-9 [14741707] Nature. 2004 May 13;429(6988):188-93 [15141213] Pharmacol Ther. 2004 Jul;103(1):21-80 [15251227] Trends Pharmacol Sci. 2004 Aug;25(8):413-22 [15276710] J Med Chem. 2004 Oct 21;47(22):5393-404 [15481977] J Mol Biol. 2004 Nov 5;343(5):1409-38 [15491621] J Med Chem. 1985 Jul;28(7):849-57 [3892003] Mol Biol Evol. 1987 Jul;4(4):406-25 [3447015] J Mol Biol. 1988 Jun 20;201(4):751-4 [3172202] Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10915-9 [1438297] J Mol Biol. 1993 Dec 5;234(3):779-815 [8254673] Nucleic Acids Res. 1994 Nov 11;22(22):4673-80 [7984417] Protein Sci. 1994 Sep;3(9):1582-96 [7833817] J Mol Biol. 1996 Aug 23;261(3):470-89 [8780787] Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9276-81 [8799191] Comput Appl Biosci. 1996 Aug;12(4):357-8 [8902363] Biochem Biophys Res Commun. 1997 Oct 20;239(2):543-7 [9344866] Mol Pharmacol. 1998 Dec;54(6):968-78 [9855624] J Biol Chem. 1999 May 21;274(21):14639-47 [10329657] Mol Interv. 2004 Dec;4(6):337-47 [15616163] Trends Pharmacol Sci. 2005 Jan;26(1):44-51 [15629204] J Med Chem. 2005 Jan 13;48(1):180-91 [15634012] J Med Chem. 2005 Feb 24;48(4):1088-97 [15715476] Curr Med Chem. 2005;12(10):1217-37 [15892633] J Med Chem. 2005 Aug 25;48(17):5448-65 [16107144] Chem Rev. 2005 Sep;105(9):3297-351 [16159154] J Chem Inf Model. 2005 Sep-Oct;45(5):1402-14 [16180917] Mol Pharmacol. 2005 Nov;68(5):1271-80 [16099840] J Med Chem. 2005 Dec 29;48(26):8108-11 [16366591] Proteins. 2006 Feb 1;62(2):509-38 [16294340] Bioorg Med Chem Lett. 2006 Apr 1;16(7):1840-5 [16439116] J Mol Biol. 2006 Mar 17;357(1):163-72 [16414074] Nat Chem Biol. 2006 Apr;2(4):207-12 [16520733] Curr Pharm Des. 2006;12(14):1771-83 [16712487] Curr Med Chem. 2006;13(14):1667-91 [16787212] Curr Pharm Des. 2006;12(17):2175-85 [16796562] Br J Pharmacol. 2006 Jul;148(5):619-28 [16702987] EMBO J. 2006 Oct 4;25(19):4615-27 [16990797] J Mol Biol. 2001 Apr 27;308(2):377-95 [11327774] J Biol Chem. 2003 Mar 28;278(13):11312-9 [12496283] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Probing the Binding Site of the A sub(1) Adenosine Receptor Reengineered for Orthogonal Recognition by Tailored Nucleosides AN - 19754451; 7571806 AB - His272 (7.43) in the seventh transmembrane domain (TM7) of the human A sub(3) adenosine receptor (AR) interacts with the 3' position of nucleosides, based on selective affinity enhancement at a H272E mutant A sub(3) AR (neoceptor) of 3'-ureido, but not 3'-OH, adenosine analogues. Here, mutation of the analogous H278 of the human A sub(1) AR to Ala, Asp, Glu, or Leu enhanced the affinity of novel 2'- and 3'-ureido adenosine analogues, such as 10 (N super(6)-cyclopentyl-3'-ureido-3'-deoxyadenosine), by >100-fold, while decreasing the affinity or potency of adenosine and other 3'-OH adenosine analogues. His278 mutant receptors produced a similar enhancement regardless of the charge character of the substituted residue, implicating steric rather than electrostatic factors in the gain of function, a hypothesis supported by rhodopsin-based molecular modeling. It was also demonstrated that this interaction was orientationaily specific; i.e., mutations at the neighboring Thr277 did not enhance the affinity for a series of 2'- and 3'-ureido nucleosides. Additionally, H-bonding groups placed on substituents at the N super(6) or 5' position demonstrated no enhancement in the mutant receptors. These reengineered human A sub(1) ARs revealed orthogonality similar to that of the A sub(3) but not the A sub(2A) AR, in which mutation of the corresponding residue, His278, to Asp did not enhance nucleoside affinity. Functionally, the H278D A sub(1) AR was detectable only in a measure of membrane potential and not in calcium mobilization. This neoceptor approach should be useful for the validation of molecular modeling and the dissection of promiscuous GPCR signaling. JF - Biochemistry (Washington) AU - Palaniappan, K K AU - Gao, Z-G AU - Ivanov, A A AU - Greaves, R AU - Adachi, H AU - Besada, P AU - Kim, HO AU - Kim, A Y AU - Choe, SA AU - Jeong, L S AU - Jacobson, KA AD - Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2007/06/26/ PY - 2007 DA - 2007 Jun 26 SP - 7437 EP - 7448 VL - 46 IS - 25 SN - 0006-2960, 0006-2960 KW - Biotechnology and Bioengineering Abstracts KW - Molecular modelling KW - Receptor mechanisms KW - Adenosine receptors KW - nucleosides KW - Calcium mobilization KW - ^AG protein-coupled receptors KW - Transmembrane domains KW - Mutation KW - Membrane potential KW - Signal transduction KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19754451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Probing+the+Binding+Site+of+the+A+sub%281%29+Adenosine+Receptor+Reengineered+for+Orthogonal+Recognition+by+Tailored+Nucleosides&rft.au=Palaniappan%2C+K+K%3BGao%2C+Z-G%3BIvanov%2C+A+A%3BGreaves%2C+R%3BAdachi%2C+H%3BBesada%2C+P%3BKim%2C+HO%3BKim%2C+A+Y%3BChoe%2C+SA%3BJeong%2C+L+S%3BJacobson%2C+KA&rft.aulast=Palaniappan&rft.aufirst=K&rft.date=2007-06-26&rft.volume=46&rft.issue=25&rft.spage=7437&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi7001828 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - nucleosides; Mutation; Adenosine receptors; Molecular modelling; Calcium mobilization; Transmembrane domains; Receptor mechanisms; Signal transduction; ^AG protein-coupled receptors; Membrane potential DO - http://dx.doi.org/10.1021/bi7001828 ER - TY - JOUR T1 - Simple quantitative detection of mitochondrial superoxide production in live cells AN - 19679424; 7434277 AB - Experiments with isolated mitochondria have established that these organelles are pivotal intracellular sources of superoxide in a variety of pathophysiological conditions. Recently, a novel fluoroprobe MitoSOX Red was introduced for selective detection of superoxide in the mitochondria of live cells and was validated with confocal microscopy. Here we show reversible reaction -7 fold dose- and time-dependent increase in mitochondrial superoxide production (measured by MitoSOX using flow cytometry and confocal microscopy) in rat cardiac derived H9c2 myocytes and/or in human coronary artery endothelial cells triggered by Antimycin A, Paraquat, Doxorubicin or high glucose. These results establish a novel, quantitative method for simple detection of mitochondrial superoxide generation simultaneously in a large population of live cells by flow cytometry. This method can also be adapted for immune cell studies with mixed population of T or B cells or their subsets to analyze mitochondrial superoxide levels using multiple labeled surface markers in individual populations. JF - Biochemical and Biophysical Research Communications AU - Mukhopadhyay, P AU - Rajesh, M AU - Yoshihiro, K AU - Hasko, G AU - Pacher, P AD - Laboratory of Physiological Studies, National Institutes of Health/NIAAA, Bethesda, MD 20892-9413, USA, pacher@mail.nih.gov Y1 - 2007/06/22/ PY - 2007 DA - 2007 Jun 22 SP - 203 EP - 208 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 358 IS - 1 SN - 0006-291X, 0006-291X KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Myocytes KW - Glucose KW - Mitochondria KW - coronary artery KW - Endothelial cells KW - Flow cytometry KW - Paraquat KW - Antimycin A KW - Heart KW - Lymphocytes B KW - Population studies KW - Doxorubicin KW - Superoxide KW - Confocal microscopy KW - Organelles KW - Surface markers KW - F 06900:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19679424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Simple+quantitative+detection+of+mitochondrial+superoxide+production+in+live+cells&rft.au=Mukhopadhyay%2C+P%3BRajesh%2C+M%3BYoshihiro%2C+K%3BHasko%2C+G%3BPacher%2C+P&rft.aulast=Mukhopadhyay&rft.aufirst=P&rft.date=2007-06-22&rft.volume=358&rft.issue=1&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1016%2Fj.bbrc.2007.04.106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Superoxide; Mitochondria; Flow cytometry; Confocal microscopy; Endothelial cells; Organelles; Glucose; Surface markers; Antimycin A; Lymphocytes B; Population studies; Doxorubicin; Heart; coronary artery; Myocytes; Paraquat DO - http://dx.doi.org/10.1016/j.bbrc.2007.04.106 ER - TY - JOUR T1 - Regulation of dendritic excitability by activity-dependent trafficking of the A-type K+ channel subunit Kv4.2 in hippocampal neurons. AN - 70646123; 17582333 AB - Voltage-gated A-type K+ channel Kv4.2 subunits are highly expressed in the dendrites of hippocampal CA1 neurons. However, little is known about the subcellular distribution and trafficking of Kv4.2-containing channels. Here we provide evidence for activity-dependent trafficking of Kv4.2 in hippocampal spines and dendrites. Live imaging and electrophysiological recordings showed that Kv4.2 internalization is induced rapidly upon glutamate receptor stimulation. Kv4.2 internalization was clathrin mediated and required NMDA receptor activation and Ca2+ influx. In dissociated hippocampal neurons, mEPSC amplitude depended on functional Kv4.2 expression level and was enhanced by stimuli that induced Kv4.2 internalization. Long-term potentiation (LTP) induced by brief glycine application resulted in synaptic insertion of GluR1-containing AMPA receptors along with Kv4.2 internalization. We also found evidence of Kv4.2 internalization upon synaptically evoked LTP in CA1 neurons of hippocampal slice cultures. These results present an additional mechanism for synaptic integration and plasticity through the activity-dependent regulation of Kv4.2 channel surface expression. JF - Neuron AU - Kim, Jinhyun AU - Jung, Sung-Cherl AU - Clemens, Ann M AU - Petralia, Ronald S AU - Hoffman, Dax A AD - Molecular Neurophysiology and Biophysics Unit, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. kimji@mail.nih.gov Y1 - 2007/06/21/ PY - 2007 DA - 2007 Jun 21 SP - 933 EP - 947 VL - 54 IS - 6 SN - 0896-6273, 0896-6273 KW - Actins KW - 0 KW - Clathrin KW - Excitatory Amino Acid Agonists KW - Potassium Channel Blockers KW - Shal Potassium Channels KW - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid KW - 77521-29-0 KW - Glycine KW - TE7660XO1C KW - Index Medicus KW - Patch-Clamp Techniques -- methods KW - Long-Term Potentiation -- radiation effects KW - Animals KW - Clathrin -- metabolism KW - Drug Interactions KW - Protein Transport -- drug effects KW - Long-Term Potentiation -- drug effects KW - Actins -- metabolism KW - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid -- pharmacology KW - Transduction, Genetic -- methods KW - Rats KW - Rats, Sprague-Dawley KW - Long-Term Potentiation -- physiology KW - Excitatory Postsynaptic Potentials -- drug effects KW - Cells, Cultured KW - Excitatory Postsynaptic Potentials -- radiation effects KW - Glycine -- pharmacology KW - Mutagenesis, Site-Directed -- methods KW - Potassium Channel Blockers -- pharmacology KW - In Vitro Techniques KW - Excitatory Amino Acid Agonists -- pharmacology KW - Embryo, Mammalian KW - Protein Transport -- physiology KW - Excitatory Postsynaptic Potentials -- physiology KW - Shal Potassium Channels -- genetics KW - Neurons -- cytology KW - Hippocampus -- cytology KW - Neurons -- physiology KW - Dendrites -- physiology KW - Shal Potassium Channels -- metabolism KW - Dendrites -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70646123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuron&rft.atitle=Regulation+of+dendritic+excitability+by+activity-dependent+trafficking+of+the+A-type+K%2B+channel+subunit+Kv4.2+in+hippocampal+neurons.&rft.au=Kim%2C+Jinhyun%3BJung%2C+Sung-Cherl%3BClemens%2C+Ann+M%3BPetralia%2C+Ronald+S%3BHoffman%2C+Dax+A&rft.aulast=Kim&rft.aufirst=Jinhyun&rft.date=2007-06-21&rft.volume=54&rft.issue=6&rft.spage=933&rft.isbn=&rft.btitle=&rft.title=Neuron&rft.issn=08966273&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-24 N1 - Date created - 2007-06-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2000 Jul 15;20(14):5191-9 [10884302] Neuron. 2001 Jan;29(1):243-54 [11182095] Nat Neurosci. 2000 Dec;3(12):1291-300 [11100150] Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1261-6 [11158627] Nat Neurosci. 2001 Sep;4(9):917-26 [11528423] Nat Neurosci. 2001 Nov;4(11):1079-85 [11687813] J Neurosci. 2002 May 15;22(10):RC223 [12006605] Curr Opin Neurobiol. 2002 Jun;12(3):279-86 [12049934] Annu Rev Neurosci. 2002;25:103-26 [12052905] Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):10144-9 [12114547] Nature. 2003 Mar 20;422(6929):302-7 [12646920] Neuron. 2003 Oct 9;40(2):361-79 [14556714] J Neurosci. 2003 Dec 17;23(37):11759-69 [14684878] Nat Neurosci. 2004 Feb;7(2):126-35 [14730307] J Neurosci Methods. 2004 Feb 15;133(1-2):81-90 [14757348] Nat Neurosci. 2004 Jul;7(7):695-6 [15208630] Science. 2004 Jul 23;305(5683):532-5 [15273397] Science. 2004 Sep 24;305(5692):1972-5 [15448273] Neuron. 2004 Oct 14;44(2):351-64 [15473972] J Physiol. 1974 Jun;239(2):325-45 [4413861] J Neurophysiol. 1982 Apr;47(4):606-21 [7069456] Neuron. 1992 Jun;8(6):1055-67 [1610565] J Neurophysiol. 1993 Aug;70(2):781-802 [8410172] Science. 1995 Apr 14;268(5208):301-4 [7716525] Trends Neurosci. 1996 Apr;19(4):126-30 [8658594] FEBS Lett. 1996 Jun 24;389(1):48-51 [8682204] J Neurophysiol. 1996 Oct;76(4):2181-91 [8899593] Neuroscience. 1997 Apr;77(3):617-21 [9070739] Nature. 1997 Jun 26;387(6636):869-75 [9202119] J Neurosci. 1998 Jan 1;18(1):10-5 [9412481] J Neurosci. 1998 May 15;18(10):3521-8 [9570783] J Neurosci. 1998 Dec 1;18(23):9835-44 [9822742] J Neurosci. 1999 Feb 15;19(4):1263-72 [9952404] Nat Neurosci. 1999 May;2(5):454-60 [10321250] Neuron. 2000 Mar;25(3):649-62 [10774732] Science. 1999 Jun 11;284(5421):1811-6 [10364548] Nat Rev Neurosci. 2004 Dec;5(12):952-62 [15550950] Mol Cell Neurosci. 2004 Dec;27(4):343-69 [15555915] Nat Biotechnol. 2004 Dec;22(12):1567-72 [15558047] Neuron. 2005 Jan 6;45(1):81-94 [15629704] Nat Neurosci. 2005 May;8(5):635-41 [15852010] Nat Neurosci. 2005 May;8(5):642-9 [15852011] Trends Neurosci. 2005 May;28(5):229-38 [15866197] Neuroscience. 2005;134(2):483-94 [16009497] Neuron. 2005 Oct 20;48(2):289-301 [16242409] J Physiol. 2005 Nov 15;569(Pt 1):41-57 [16141270] Science. 2005 Nov 25;310(5752):1340-3 [16311338] J Neurosci. 2006 Mar 8;26(10):2684-91 [16525047] Neuron. 2006 Apr 20;50(2):291-307 [16630839] Neurobiol Dis. 2006 Nov;24(2):245-53 [16934482] J Neurosci. 2006 Nov 22;26(47):12143-51 [17122039] J Neurosci. 2006 Nov 22;26(47):12274-82 [17122053] Nat Neurosci. 2000 Dec;3(12):1282-90 [11100149] Neuron. 2000 Nov;28(2):511-25 [11144360] Comment In: Neuron. 2007 Jun 21;54(6):850-2 [17582324] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sexual Quality of Life in Women with Newly Diagnosed Breast Cancer AN - 61419203; 200705122 AB - Sexual quality of life (QOL) is a significant concern for breast cancer survivors. This study investigated sexual quality of life in a sample of 191 newly diagnosed breast cancer patients. Sixty percent of the sample indicated disruption in their sexual quality of life. Sexual QOL during treatment was significantly more disrupted among women who received chemotherapy, were younger, had higher stage of disease, reported more depressive symptoms near time of diagnosis, and underwent a total mastectomy. Hierarchical linear regression was used to model sexual QOL and feelings of sexual attractiveness. Worse physical quality of life, chemotherapy, and depressive symptoms near time of diagnosis were associated with worse sexual QOL during treatment. An interaction between chemotherapy status and type of surgery, for feelings of sexual attractiveness, suggested that chemotherapy affected sexual attractiveness only among women who underwent a lumpectomy. These results add to growing evidence that sexual QOL is a multidimensional construct with aspects differentially affected by variables related to cancer survivorship. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Journal of Psychosocial Oncology AU - Beckjord, Ellen AU - Campas, Bruce E AD - Cancer Prevention Fellowship Program, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, 20892-7361 email: beckjore@mail.nih.gov Y1 - 2007/06/20/ PY - 2007 DA - 2007 Jun 20 SP - 19 EP - 36 PB - Haworth Press, Binghamton NY VL - 25 IS - 2 SN - 0734-7332, 0734-7332 KW - Diagnosis KW - Breast Cancer KW - Quality of Life KW - Patients KW - Females KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61419203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Psychosocial+Oncology&rft.atitle=Sexual+Quality+of+Life+in+Women+with+Newly+Diagnosed+Breast+Cancer&rft.au=Beckjord%2C+Ellen%3BCampas%2C+Bruce+E&rft.aulast=Beckjord&rft.aufirst=Ellen&rft.date=2007-06-20&rft.volume=25&rft.issue=2&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Journal+of+Psychosocial+Oncology&rft.issn=07347332&rft_id=info:doi/10.1300%2FJ077v25n02_02 LA - English DB - Social Services Abstracts N1 - Date revised - 2007-12-10 N1 - Last updated - 2016-09-28 N1 - CODEN - JPONED N1 - SubjectsTermNotLitGenreText - Quality of Life; Females; Diagnosis; Breast Cancer; Patients DO - http://dx.doi.org/10.1300/J077v25n02_02 ER - TY - JOUR T1 - Cross-reactive HIV-1 neutralizing monoclonal antibodies selected by screening of an immune human phage library against an envelope glycoprotein (gp140) isolated from a patient (R2) with broadly HIV-1 neutralizing antibodies AN - 19679169; 7433232 AB - Elicitation of broadly cross-reactive neutralizing antibodies (bcnAbs) in HIV infections is rare. To test the hypothesis that such antibodies could be elicited by HIV envelope glycoproteins (Envs) with unusual immunogenic properties and to identify novel bcnAbs, we used a soluble Env ectodomain (gp140) from a donor (R2) with high level of bcnAbs as an antigen for panning of an immune phage-displayed antibody library. The panning with the R2 Env resulted in significantly higher number of cross-reactive antibody clones than by using Envs from two other isolates (89.6 and IIIB). Two of the identified human monoclonal antibodies (hmAbs), m22 and m24, had sequences, neutralizing and binding activities similar or identical to those of the gp120-specific bcnAbs m18 and m14. The use of the R2 Env but not other Envs for panning resulted in the identification of a novel gp41-specific hmAb, m46. For several of the tested HIV-1 primary isolates its potency on molar basis was comparable to that of T20. It inhibited entry of primary isolates from different clades with an increased activity for cell lines with low CCR5 surface concentrations. The m46 neutralizing activity against a panel of clade C isolates was significantly higher in an assay based on peripheral blood mononuclear cells (4 out of 5 isolates were neutralized with an IC sub(5) sub(0) in the range from 1.5 to 25 mu g/ml) than in an assay based on a cell line with relatively high concentration of cell-surface-associated CCR5. In contrast to 2F5 and Z13, this antibody did not bind to denatured gp140 and gp41-derived peptides indicating a conformational nature of its epitope. It bound to a 5-helix bundle but not to N-heptad repeat coiled coils and a 6-helix bundle construct indicating contribution of both gp41 heptad repeats to its epitope and to a possible mechanism of neutralization. These results indicate that the R2 Env may contain unique exposed conserved epitopes that could contribute to its ability to elicit broadly cross-reactive antibodies in animals and humans; the newly identified antibodies may help in the development of novel vaccine immunogens and therapeutics. JF - Virology AU - Choudhry, V AU - Zhang, MY AU - Sidorov, IA AU - Louis, J M AU - Harris, I AU - Dimitrov, A S AU - Bouma, P AU - Cham, F AU - Choudhary, A AU - Rybak, S M AU - Fouts, T AU - Montefiori, D C AU - Broder, C C AU - Quinnan, G V AU - Dimitrov, D S AD - CCRNP, NCI-Frederick, NIH, Frederick, MD 21702, USA, dimitrov@ncifcrf.gov Y1 - 2007/06/20/ PY - 2007 DA - 2007 Jun 20 SP - 79 EP - 90 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 363 IS - 1 SN - 0042-6822, 0042-6822 KW - HIV-1 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Phages KW - glycoprotein gp41 KW - Monoclonal antibodies KW - Panning KW - CCR5 protein KW - Infection KW - Peripheral blood mononuclear cells KW - Envelopes KW - Human immunodeficiency virus 1 KW - Glycoproteins KW - Vaccines KW - antibody libraries KW - Epitopes KW - W 30905:Medical Applications KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19679169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Cross-reactive+HIV-1+neutralizing+monoclonal+antibodies+selected+by+screening+of+an+immune+human+phage+library+against+an+envelope+glycoprotein+%28gp140%29+isolated+from+a+patient+%28R2%29+with+broadly+HIV-1+neutralizing+antibodies&rft.au=Choudhry%2C+V%3BZhang%2C+MY%3BSidorov%2C+IA%3BLouis%2C+J+M%3BHarris%2C+I%3BDimitrov%2C+A+S%3BBouma%2C+P%3BCham%2C+F%3BChoudhary%2C+A%3BRybak%2C+S+M%3BFouts%2C+T%3BMontefiori%2C+D+C%3BBroder%2C+C+C%3BQuinnan%2C+G+V%3BDimitrov%2C+D+S&rft.aulast=Choudhry&rft.aufirst=V&rft.date=2007-06-20&rft.volume=363&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/10.1016%2Fj.virol.2007.01.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Phages; Peripheral blood mononuclear cells; Envelopes; glycoprotein gp41; Monoclonal antibodies; Panning; CCR5 protein; Vaccines; Glycoproteins; Infection; antibody libraries; Epitopes; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1016/j.virol.2007.01.015 ER - TY - JOUR T1 - Abnormality of motor cortex excitability in peripherally induced dystonia. AN - 85412156; pmid-17415790 AB - It is widely accepted that peripheral trauma such as soft tissue injuries can trigger dystonia, although little is known about the underlying mechanism. Because peripheral injury only rarely appears to elicit dystonia, a predisposing vulnerability in cortical motor areas might play a role. Using single and paired-pulse pulse transcranial magnetic stimulation, we evaluated motor cortex excitability of a hand muscle in a patient with peripherally induced foot dystonia, in her brother with craniocervical dystonia, and in her unaffected sister, and compared their results to those from a group of normal subjects. In the patient with peripherally induced dystonia, we found a paradoxical intracortical facilitation at short interstimulus intervals of 3 and 5 milliseconds, at which regular intracortical inhibition (ICI) occurred in healthy subjects. These findings suggest that the foot dystonia may have been precipitated as the result of a preexisting abnormality of motor cortex excitability. Furthermore, the abnormality of ICI in her brother and sister indicates that altered motor excitability may be a hereditary predisposition. The study demonstrates that the paired-pulse technique is a useful tool to assess individual vulnerability, which can be particularly relevant when the causal association between trauma and dystonia is less evident. JF - Movement disorders : official journal of the Movement Disorder Society AU - Bohlhalter, Stephan AU - Leon-Sarmiento, Fidias E AU - Hallett, Mark AD - Human Motor Control Section, National Institute of Neurological Disorders and Stroke NINDS, NIH, Bethesda, MD 20892-1428, USA. Y1 - 2007/06/15/ PY - 2007 DA - 2007 Jun 15 SP - 1186 EP - 1189 VL - 22 IS - 8 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - *Arousal: physiology KW - Dystonia: diagnosis KW - *Dystonia: physiopathology KW - Dystonia: therapy KW - Evoked Potentials, Motor: physiology KW - Female KW - Hand: innervation KW - Hand: physiopathology KW - Humans KW - Male KW - Middle Aged KW - *Motor Cortex: physiopathology KW - Muscle, Skeletal: innervation KW - Muscle, Skeletal: physiopathology KW - Transcranial Magnetic Stimulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85412156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Abnormality+of+motor+cortex+excitability+in+peripherally+induced+dystonia.&rft.au=Bohlhalter%2C+Stephan%3BLeon-Sarmiento%2C+Fidias+E%3BHallett%2C+Mark&rft.aulast=Bohlhalter&rft.aufirst=Stephan&rft.date=2007-06-15&rft.volume=22&rft.issue=8&rft.spage=1186&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Accumulation of oxidatively induced DNA damage in human breast cancer cell lines following treatment with hydrogen peroxide. AN - 70663390; 17568196 AB - Breast cancer is a leading cause of cancer deaths in women. Although the causes of this disease are largely unknown, inefficient repair of oxidatively induced DNA lesions has been thought to play a major role in the transformation of normal breast tissue to malignant breast tissue. Previous studies have revealed higher levels of 8-hydroxyguanine in malignant breast tissue compared to non-malignant breast tissue. Furthermore, some breast cancer cell lines have greatly reduced capacity to repair this lesion suggesting that oxidatively induced DNA lesions may be elevated in breast cancer cells. We used liquid chromatography/mass spectrometry and gas chromatography/mass spectrometry to measure the levels of 8-hydroxy-2'-deoxyadenosine, (5'S)-8,5'-cyclo-2'-deoxyadenosine, 2,6-diamino-4-hydroxy-5-formamidopyrimidine, and 4,6-diamino-5-formamidopyrimidine in MCF-7 and HCC1937 breast cancer cell lines before and after exposure to H(2)O(2) followed by a DNA repair period. We show that H(2)O(2)-treated HCC1937 and MCF-7 cell lines accumulate significantly higher levels of these lesions than the untreated cells despite a 1 h repair period. In contrast, the four lesions did not accumulate to any significant level in H(2)O(2)-treated non-malignant cell lines, AG11134 and HCC1937BL. Furthermore, MCF-7 and HCC1937 cell lines were deficient in the excision repair of all the four lesions studied. These results suggest that oxidatively induced DNA damage and its repair may be critical in the etiology of breast cancer. JF - Cell cycle (Georgetown, Tex.) AU - Nyaga, Simon G AU - Jaruga, Pawel AU - Lohani, Althaf AU - Dizdaroglu, Miral AU - Evans, Michele K AD - Laboratory of Cellular and Molecular Biology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA. Y1 - 2007/06/15/ PY - 2007 DA - 2007 Jun 15 SP - 1472 EP - 1478 VL - 6 IS - 12 KW - 8-hydroxy-2'-deoxyadenosine KW - 0 KW - Cell Extracts KW - Deoxyadenosines KW - Oligonucleotides KW - Pyrimidines KW - 8,5'-cyclo-2'-deoxyadenosine KW - 117182-88-4 KW - 2,6-diamino-4-hydroxy-5-formamidopyrimidine KW - 133310-38-0 KW - 4,6-diamino-5-N-formamidopyrimidine KW - 5122-36-1 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Index Medicus KW - Oxidation-Reduction KW - Molecular Structure KW - Analysis of Variance KW - Cell Extracts -- pharmacology KW - Humans KW - Pyrimidines -- metabolism KW - Gas Chromatography-Mass Spectrometry KW - Chromatography, Liquid KW - Cell Line, Tumor KW - Deoxyadenosines -- metabolism KW - Oligonucleotides -- genetics KW - Female KW - Hydrogen Peroxide -- toxicity KW - DNA Damage KW - Breast Neoplasms -- etiology KW - Breast Neoplasms -- metabolism KW - DNA Repair -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70663390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+cycle+%28Georgetown%2C+Tex.%29&rft.atitle=Accumulation+of+oxidatively+induced+DNA+damage+in+human+breast+cancer+cell+lines+following+treatment+with+hydrogen+peroxide.&rft.au=Nyaga%2C+Simon+G%3BJaruga%2C+Pawel%3BLohani%2C+Althaf%3BDizdaroglu%2C+Miral%3BEvans%2C+Michele+K&rft.aulast=Nyaga&rft.aufirst=Simon&rft.date=2007-06-15&rft.volume=6&rft.issue=12&rft.spage=1472&rft.isbn=&rft.btitle=&rft.title=Cell+cycle+%28Georgetown%2C+Tex.%29&rft.issn=1551-4005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-24 N1 - Date created - 2007-06-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dose-escalating and pharmacologic study of oxaliplatin in adult cancer patients with impaired hepatic function: a National Cancer Institute Organ Dysfunction Working Group study. AN - 70611709; 17575231 AB - To determine the toxicities, pharmacokinetics, and maximally tolerated doses of oxaliplatin in patients with hepatic impairment and to develop formal guidelines for oxaliplatin dosing in this patient population. Sixty adult cancer patients with variable hepatic function received i.v. oxaliplatin ranging from 60 to 130 mg/m(2) every 3 weeks. Patients were stratified by levels of total bilirubin, aspartate aminotransferase (AST), and alkaline phosphatase (AP) into five cohorts based on the degree of hepatic dysfunction: control group A [bilirubin, AST, and AP 2.5 x ULN, or AP > 5 x ULN), severe dysfunction group D (bilirubin > 3.0 mg/dL, any AST, and any AP), and liver transplantation group E (any bilirubin, any AST, and any AP). Doses were escalated in cohorts of three patients, and urine and plasma ultrafiltrates were assayed for platinum concentrations. Dose escalation of single-agent oxaliplatin to 130 mg/m(2) was well tolerated in all cohorts. Platinum clearance did not correlate with any liver function test. Two of 56 assessable patients with a diagnosis of laryngeal carcinoma and cervical adenocarcinoma experienced partial responses lasting 3 and 5.5 months. Oxaliplatin at 130 mg/m(2) every 3 weeks was well tolerated in all patients with impaired liver function. Dose reductions of single-agent oxaliplatin are not indicated in patients with hepatic dysfunction. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Synold, Timothy W AU - Takimoto, Chris H AU - Doroshow, James H AU - Gandara, David AU - Mani, Sridhar AU - Remick, Scot C AU - Mulkerin, Daniel L AU - Hamilton, Anne AU - Sharma, Sunil AU - Ramanathan, Ramesh K AU - Lenz, Heinz Josef AU - Graham, Martin AU - Longmate, Jeffrey AU - Kaufman, Bennett M AU - Ivy, Percy AU - National Cancer Institute Organ Dysfunction Working Group AD - City of Hope Comprehensive Cancer Center, Duarte, California, USA. ; National Cancer Institute Organ Dysfunction Working Group Y1 - 2007/06/15/ PY - 2007 DA - 2007 Jun 15 SP - 3660 EP - 3666 VL - 13 IS - 12 SN - 1078-0432, 1078-0432 KW - Antineoplastic Agents KW - 0 KW - Organoplatinum Compounds KW - oxaliplatin KW - 04ZR38536J KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Maximum Tolerated Dose KW - Liver Function Tests KW - Male KW - Female KW - Neoplasms -- drug therapy KW - Neoplasms -- complications KW - Liver Diseases -- complications KW - Organoplatinum Compounds -- pharmacology KW - Antineoplastic Agents -- metabolism KW - Organoplatinum Compounds -- metabolism KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70611709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Dose-escalating+and+pharmacologic+study+of+oxaliplatin+in+adult+cancer+patients+with+impaired+hepatic+function%3A+a+National+Cancer+Institute+Organ+Dysfunction+Working+Group+study.&rft.au=Synold%2C+Timothy+W%3BTakimoto%2C+Chris+H%3BDoroshow%2C+James+H%3BGandara%2C+David%3BMani%2C+Sridhar%3BRemick%2C+Scot+C%3BMulkerin%2C+Daniel+L%3BHamilton%2C+Anne%3BSharma%2C+Sunil%3BRamanathan%2C+Ramesh+K%3BLenz%2C+Heinz+Josef%3BGraham%2C+Martin%3BLongmate%2C+Jeffrey%3BKaufman%2C+Bennett+M%3BIvy%2C+Percy%3BNational+Cancer+Institute+Organ+Dysfunction+Working+Group&rft.aulast=Synold&rft.aufirst=Timothy&rft.date=2007-06-15&rft.volume=13&rft.issue=12&rft.spage=3660&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-04 N1 - Date created - 2007-06-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cell shrinkage and monovalent cation fluxes: role in apoptosis. AN - 70602753; 17321483 AB - The loss of cell volume or cell shrinkage has been a morphological hallmark of the programmed cell death process known as apoptosis. This isotonic loss of cell volume has recently been term apoptotic volume decrease or AVD to distinguish it from inherent volume regulatory responses that occurs in cells under anisotonic conditions. Recent studies examining the intracellular signaling pathways that result in this unique cellular characteristic have determined that a fundamental movement of ions, particularly monovalent ions, underlie the AVD process and plays an important role on controlling the cell death process. An efflux of intracellular potassium was shown to be a critical aspect of the AVD process, as preventing this ion loss could protect cells from apoptosis. However, potassium plays a complex role as a loss of intracellular potassium has also been shown to be beneficial to the health of the cell. Additionally, the mechanisms that a cell employs to achieve this loss of intracellular potassium vary depending on the cell type and stimulus used to induce apoptosis, suggesting multiple ways exist to accomplish the same goal of AVD. Additionally, sodium and chloride have been shown to play a vital role during cell death in both the signaling and control of AVD in various apoptotic model systems. This review examines the relationship between this morphological change and intracellular monovalent ions during apoptosis. JF - Archives of biochemistry and biophysics AU - Bortner, Carl D AU - Cidlowski, John A AD - The Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Department of Health and Human Services, National Institutes of Health, Research Triangle Park, NC 27709, USA. bortner@neihs.nih.gov Y1 - 2007/06/15/ PY - 2007 DA - 2007 Jun 15 SP - 176 EP - 188 VL - 462 IS - 2 SN - 0003-9861, 0003-9861 KW - Apoptosis Regulatory Proteins KW - 0 KW - Cations KW - Ion Channels KW - Chlorine KW - 4R7X1O2820 KW - Sodium KW - 9NEZ333N27 KW - Potassium KW - RWP5GA015D KW - Index Medicus KW - Oxidative Stress -- physiology KW - Models, Biological KW - Chlorine -- metabolism KW - Potassium -- metabolism KW - Cytoprotection -- physiology KW - Sodium -- metabolism KW - Ion Channel Gating -- physiology KW - Cell Size KW - Apoptosis -- physiology KW - Apoptosis Regulatory Proteins -- metabolism KW - Ion Channels -- physiology KW - Water-Electrolyte Balance -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70602753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+biochemistry+and+biophysics&rft.atitle=Cell+shrinkage+and+monovalent+cation+fluxes%3A+role+in+apoptosis.&rft.au=Bortner%2C+Carl+D%3BCidlowski%2C+John+A&rft.aulast=Bortner&rft.aufirst=Carl&rft.date=2007-06-15&rft.volume=462&rft.issue=2&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=Archives+of+biochemistry+and+biophysics&rft.issn=00039861&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-31 N1 - Date created - 2007-06-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Physiol. 1996 Sep;271(3 Pt 1):C950-61 [8843726] Am J Physiol. 1997 Jan;272(1 Pt 1):G106-15 [9038883] Am J Physiol Cell Physiol. 2002 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and comorbid disruptive behavior disorders: evidence of pleiotropy and new susceptibility loci. AN - 70597766; 16950213 AB - Attention-deficit/hyperactivity disorder (ADHD) comorbid with oppositional defiant disorder (ODD) or conduct disorder (CD) and substance abuse/dependence seems to represent a specific subset within the phenotypic ADHD spectrum. We applied complex segregation and linkage analyses in a set of multigenerational families densely segregating ADHD comorbid with ODD, CD, alcohol abuse/dependence, and nicotine dependence. Our data suggest that ADHD cosegregates with disruptive behaviors as a unique, phenotypically variable trait as evidenced by highly significant pair-wise linkages among: ADHD and ODD (logarithm of odds [LOD]=14.19), ADHD and CD (LOD=5.34), ODD and CD (LOD=6.68), and CD and alcohol abuse/dependence (LOD=3.98). In addition to previously reported ADHD susceptibility loci, we found evidence of linkage for comorbid ADHD phenotypes to loci at 8q24, 2p21-22.3, 5p13.1-p13.3, 12p11.23-13.3, 8q15, and 14q21.1-22.2. These results were replicated with an affected status phenotype derived from latent class clusters. Patterns of cosegregation of ADHD with comorbidities can inform our understanding of the inheritance patterns not only of ADHD but also of disruptive behavioral disorders and alcohol abuse/dependence. Refining the comorbid ADHD phenotype by determining the cosegregation profile of specific comorbidities might be a powerful tool for defining significant regions of linkage. JF - Biological psychiatry AU - Jain, Mahim AU - Palacio, Luis Guillermo AU - Castellanos, F Xavier AU - Palacio, Juan David AU - Pineda, David AU - Restrepo, Maria I AU - Muñoz, Juan F AU - Lopera, Francisco AU - Wallis, Deeann AU - Berg, Kate AU - Bailey-Wilson, Joan E AU - Arcos-Burgos, Mauricio AU - Muenke, Maximilian AD - Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-3717, USA. Y1 - 2007/06/15/ PY - 2007 DA - 2007 Jun 15 SP - 1329 EP - 1339 VL - 61 IS - 12 SN - 0006-3223, 0006-3223 KW - Index Medicus KW - Humans KW - Conduct Disorder -- epidemiology KW - Conduct Disorder -- genetics KW - Linkage Disequilibrium -- genetics KW - Child KW - Chromosome Mapping KW - Comorbidity KW - Child, Preschool KW - Phenotype KW - Risk Factors KW - Genetic Predisposition to Disease KW - Adolescent KW - Substance-Related Disorders -- genetics KW - Female KW - Male KW - Substance-Related Disorders -- epidemiology KW - Attention Deficit Disorder with Hyperactivity -- genetics KW - Attention Deficit Disorder with Hyperactivity -- epidemiology KW - Chromosome Aberrations KW - Attention Deficit and Disruptive Behavior Disorders -- epidemiology KW - Attention Deficit and Disruptive Behavior Disorders -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70597766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Attention-deficit%2Fhyperactivity+disorder+and+comorbid+disruptive+behavior+disorders%3A+evidence+of+pleiotropy+and+new+susceptibility+loci.&rft.au=Jain%2C+Mahim%3BPalacio%2C+Luis+Guillermo%3BCastellanos%2C+F+Xavier%3BPalacio%2C+Juan+David%3BPineda%2C+David%3BRestrepo%2C+Maria+I%3BMu%C3%B1oz%2C+Juan+F%3BLopera%2C+Francisco%3BWallis%2C+Deeann%3BBerg%2C+Kate%3BBailey-Wilson%2C+Joan+E%3BArcos-Burgos%2C+Mauricio%3BMuenke%2C+Maximilian&rft.aulast=Jain&rft.aufirst=Mahim&rft.date=2007-06-15&rft.volume=61&rft.issue=12&rft.spage=1329&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-23 N1 - Date created - 2007-06-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene. AN - 70581272; 17353346 AB - Malignancies arising from retrovirally transduced hematopoietic stem cells have been reported in animal models and human gene therapy trials. Whether mature lymphocytes are susceptible to insertional mutagenesis is unknown. We have characterized a primary human CD8(+) T-cell clone, which exhibited logarithmic ex vivo growth in the absence of exogenous cytokine support for more than 1 year after transduction with a murine leukemia virus-based vector encoding the T-cell growth factor IL-15. Phenotypically, the clone was CD28(-), CD45RA(-), CD45RO(+), and CD62L(-), a profile consistent with effector memory T lymphocytes. After gene transfer with tumor-antigen-specific T-cell receptors, the clone secreted IFN-gamma upon encountering tumor targets, providing further evidence that they derived from mature lymphocytes. Gene-expression analyses revealed no evidence of insertional activation of genes flanking the retroviral insertion sites. The clone exhibited constitutive telomerase activity, and the presence of autocrine loop was suggested by impaired cell proliferation following knockdown of IL-15R alpha expression. The generation of this cell line suggests that nonphysiologic expression of IL-15 can result in the long-term in vitro growth of mature human T lymphocytes. The cytokine-independent growth of this line was a rare event that has not been observed in other IL-15 vector transduction experiments or with any other integrating vector system. It does not appear that the retroviral vector integration sites played a role in the continuous growth of this cell clone, but this remains under investigation. JF - Blood AU - Hsu, Cary AU - Jones, Stephanie A AU - Cohen, Cyrille J AU - Zheng, Zhili AU - Kerstann, Keith AU - Zhou, Juhua AU - Robbins, Paul F AU - Peng, Peter D AU - Shen, Xinglei AU - Gomes, Theotonius J AU - Dunbar, Cynthia E AU - Munroe, David J AU - Stewart, Claudia AU - Cornetta, Kenneth AU - Wangsa, Danny AU - Ried, Thomas AU - Rosenberg, Steven A AU - Morgan, Richard A AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/06/15/ PY - 2007 DA - 2007 Jun 15 SP - 5168 EP - 5177 VL - 109 IS - 12 SN - 0006-4971, 0006-4971 KW - Cytokines KW - 0 KW - Interleukin-15 KW - Telomerase KW - EC 2.7.7.49 KW - Abridged Index Medicus KW - Index Medicus KW - Clone Cells -- cytology KW - Cells, Cultured KW - Humans KW - Transduction, Genetic KW - Clone Cells -- metabolism KW - Retroviridae -- genetics KW - Telomerase -- metabolism KW - Immunophenotyping KW - T-Lymphocyte Subsets KW - CD8-Positive T-Lymphocytes -- cytology KW - Cytokines -- pharmacology KW - CD8-Positive T-Lymphocytes -- metabolism KW - Interleukin-15 -- genetics KW - Cell Proliferation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70581272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Cytokine-independent+growth+and+clonal+expansion+of+a+primary+human+CD8%2B+T-cell+clone+following+retroviral+transduction+with+the+IL-15+gene.&rft.au=Hsu%2C+Cary%3BJones%2C+Stephanie+A%3BCohen%2C+Cyrille+J%3BZheng%2C+Zhili%3BKerstann%2C+Keith%3BZhou%2C+Juhua%3BRobbins%2C+Paul+F%3BPeng%2C+Peter+D%3BShen%2C+Xinglei%3BGomes%2C+Theotonius+J%3BDunbar%2C+Cynthia+E%3BMunroe%2C+David+J%3BStewart%2C+Claudia%3BCornetta%2C+Kenneth%3BWangsa%2C+Danny%3BRied%2C+Thomas%3BRosenberg%2C+Steven+A%3BMorgan%2C+Richard+A&rft.aulast=Hsu&rft.aufirst=Cary&rft.date=2007-06-15&rft.volume=109&rft.issue=12&rft.spage=5168&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-13 N1 - Date created - 2007-06-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2001 May 24;411(6836):494-8 [11373684] Blood. 2004 Jun 1;103(11):4062-9 [14976042] Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9742-7 [11481446] J Immunol. 2001 Dec 1;167(11):6356-65 [11714800] Gene Ther. 2002 Apr;9(8):527-35 [11948378] Science. 2002 Apr 19;296(5567):497 [11964471] Cancer Cell. 2002 Jun;1(5):417-20 [12124171] PLoS Biol. 2004 Aug;2(8):E234 [15314653] Mol Ther. 2004 Nov;10(5):874-81 [15509505] Science. 1989 Sep 29;245(4925):1493-6 [2789432] Hum Gene Ther. 1991 Spring;2(1):5-14 [1863639] Exp Cell Res. 1993 Jul;207(1):131-5 [8319764] J Exp Med. 1996 Jun 1;183(6):2471-9 [8676067] Science. 1996 Jul 26;273(5274):494-7 [8662537] Histochem Cell Biol. 1997 Oct-Nov;108(4-5):299-305 [9387921] Nat Biotechnol. 1998 Aug;16(8):743-7 [9702772] J Immunol. 1999 Apr 15;162(8):4521-6 [10201990] PLoS Biol. 2004 Dec;2(12):e423 [15550989] Cell Mol Life Sci. 2005 Feb;62(4):397-409 [15719167] Cancer Res. 2005 Mar 1;65(5):2001-8 [15753400] J Immunol. 2005 Apr 1;174(7):4019-24 [15778359] J Clin Oncol. 2005 Apr 1;23(10):2346-57 [15800326] Hum Gene Ther. 2005 Apr;16(4):457-72 [15871677] Science. 2005 May 20;308(5725):1171-4 [15905401] J Immunol. 2005 Nov 1;175(9):5799-808 [16237072] J Immunol. 2005 Nov 15;175(10):7046-52 [16272366] Pediatr Dev Pathol. 2005 Sep-Oct;8(5):550-6 [16211447] J Immunol. 2005 Dec 1;175(11):7226-34 [16301627] Trends Biotechnol. 2005 Dec;23(12):589-97 [16216357] Mol Ther. 2006 Jan;13(1):151-9 [16140584] Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1457-62 [16432223] Blood. 2006 Mar 1;107(5):1751-60 [16269617] Hum Gene Ther. 2006 Mar;17(3):253-63 [16544975] Annu Rev Immunol. 2006;24:657-79 [16551262] Nat Med. 2006 Apr;12(4):401-9 [16582916] Nature. 2006 Apr 27;440(7088):1123 [16641981] Blood. 2006 May 15;107(10):3865-7 [16439674] Immunol Lett. 2006 May 15;105(1):26-37 [16442639] DNA Repair (Amst). 2006 Sep 8;5(9-10):1282-97 [16893685] Cancer Res. 2006 Sep 1;66(17):8878-86 [16951205] Cancer Genet Cytogenet. 2007 Jan 1;172(1):1-11 [17175373] J Immunol. 2000 Nov 1;165(9):4978-84 [11046025] Blood. 2001 Jan 1;97(1):14-32 [11133738] J Exp Med. 2001 Jan 15;193(2):219-31 [11208862] Blood. 2002 Oct 15;100(8):2737-43 [12351380] N Engl J Med. 2002 Nov 14;347(20):1593-603 [12432047] Clin Immunol. 2002 Nov;105(2):117-25 [12482386] Science. 2003 Jun 13;300(5626):1749-51 [12805549] Nat Rev Cancer. 2003 Jul;3(7):477-88 [12835668] Science. 2003 Oct 17;302(5644):415-9 [14564000] Acta Haematol. 2003;110(2-3):107-9 [14583670] Science. 2004 Jan 16;303(5656):333 [14726584] Mol Ther. 2004 Jan;9(1):5-13 [14741772] Blood. 2001 Aug 1;98(3):597-603 [11468156] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2. AN - 70527887; 17512459 AB - Nrf2 is a key transcription factor in the cellular response to oxidative stress. In this study we identify two phosphorylated forms of endogenous human Nrf2 after chemically induced oxidative stress and provide evidence that protein kinase CK2-mediated sequential phosphorylation plays potential roles in Nrf2 activation and degradation. Human Nrf2 has a predicted molecular mass of 66 kDa. However, immunoblots showed that two bands at 98 and 118 kDa, which are identified as phosphorylated forms, are increased in response to Nrf2 inducers. In addition, human Nrf2 was found to be a substrate for CK2 which mediated two steps of phosphorylation, resulting in two forms of Nrf2 migrating with differing M(r) at 98 kDa (Nrf2-98) and 118 kDa (Nrf2-118). Our results support a role in which calmodulin binding regulates CK2 activity, in that cold (25 degrees C) Ca(2+)-free media (cold/Ca(2+)-free) decreased both cellular calcium levels and CK2-calmodulin binding and induced Nrf2-118 formation, the latter of which was prevented by CK2-specific inhibitors. Gel shift assays showed that the Nrf2-118 generated under cold/Ca(2+)-free conditions does not bind to the antioxidant response element, indicating that Nrf2-98 has transcriptional activity. In contrast, Nrf2-118 is more susceptible to degradation. These results provide evidence for phosphorylation by CK2 as a critical controlling factor in Nrf2-mediated cellular antioxidant response. JF - Free radical biology & medicine AU - Pi, Jingbo AU - Bai, Yushi AU - Reece, Jeffrey M AU - Williams, Jason AU - Liu, Dianxin AU - Freeman, Michael L AU - Fahl, William E AU - Shugar, David AU - Liu, Jie AU - Qu, Wei AU - Collins, Sheila AU - Waalkes, Michael P AD - Laboratory of Comparative Carcinogenesis, NCI at NIEHS, NIH, Research Triangle Park, NC 27709, USA. Y1 - 2007/06/15/ PY - 2007 DA - 2007 Jun 15 SP - 1797 EP - 1806 VL - 42 IS - 12 SN - 0891-5849, 0891-5849 KW - Calmodulin KW - 0 KW - NF-E2-Related Factor 2 KW - NFE2L2 protein, human KW - Casein Kinase II KW - EC 2.7.11.1 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Calmodulin -- metabolism KW - Humans KW - Electrophoretic Mobility Shift Assay KW - Immunoprecipitation KW - Transcription, Genetic KW - Plasmids KW - Protein Binding KW - Transcriptional Activation KW - Calcium -- metabolism KW - Blotting, Western KW - Phosphorylation KW - Cells, Cultured KW - Keratinocytes -- cytology KW - Keratinocytes -- metabolism KW - Response Elements KW - Signal Transduction KW - Casein Kinase II -- pharmacology KW - Gene Expression Regulation KW - NF-E2-Related Factor 2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70527887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Molecular+mechanism+of+human+Nrf2+activation+and+degradation%3A+role+of+sequential+phosphorylation+by+protein+kinase+CK2.&rft.au=Pi%2C+Jingbo%3BBai%2C+Yushi%3BReece%2C+Jeffrey+M%3BWilliams%2C+Jason%3BLiu%2C+Dianxin%3BFreeman%2C+Michael+L%3BFahl%2C+William+E%3BShugar%2C+David%3BLiu%2C+Jie%3BQu%2C+Wei%3BCollins%2C+Sheila%3BWaalkes%2C+Michael+P&rft.aulast=Pi&rft.aufirst=Jingbo&rft.date=2007-06-15&rft.volume=42&rft.issue=12&rft.spage=1797&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=08915849&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-24 N1 - Date created - 2007-05-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Biophys Res Commun. 2003 Jun 20;306(1):129-33 [12788077] J Biol Chem. 1997 Aug 15;272(33):20820-7 [9252407] Mol Cell Biol. 2003 Oct;23(20):7198-209 [14517290] Exp Cell Res. 2003 Nov 1;290(2):234-45 [14567983] J Biol Chem. 2003 Nov 7;278(45):44675-82 [12947090] Eukaryot Cell. 2003 Dec;2(6):1220-33 [14665457] Curr Cancer Drug Targets. 2004 Feb;4(1):77-84 [14965269] Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2046-51 [14764898] Free Radic Biol Med. 2004 May 15;36(10):1208-13 [15110385] Annu Rev Biochem. 1998;67:425-79 [9759494] Int J Immunopharmacol. 1999 Sep;21(9):547-59 [10501624] Mol Cell Biol. 2004 Dec;24(24):10941-53 [15572695] Biochem Cell Biol. 2004 Dec;82(6):681-93 [15674436] Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12731-6 [10535991] J Biol Chem. 2000 Dec 22;275(51):39907-13 [10986282] J Biol Chem. 2001 Jan 12;276(2):993-8 [11035045] Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3410-5 [11248092] Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4611-6 [11287661] FEBS Lett. 2001 May 4;496(1):44-8 [11343704] Trends Cell Biol. 2002 May;12(5):226-30 [12062170] J Biol Chem. 2002 Jul 5;277(27):24232-42 [11978799] Oncogene. 2002 Aug 8;21(34):5301-12 [12149651] Eur J Biochem. 2002 Aug;269(15):3619-31 [12153558] J Cell Sci. 2002 Oct 15;115(Pt 20):3873-8 [12244125] Eur J Biochem. 2002 Oct;269(20):5056-65 [12383265] J Biol Chem. 2002 Nov 8;277(45):42769-74 [12198130] Nitric Oxide. 2002 Dec;7(4):244-53 [12446173] J Biol Chem. 2003 Jan 24;278(4):2396-402 [12441344] J Biol Chem. 2003 Feb 14;278(7):4536-41 [12446695] FASEB J. 2003 Mar;17(3):349-68 [12631575] Biochem Biophys Res Commun. 2003 May 30;305(2):271-7 [12745069] Hepatology. 2004 May;39(5):1267-76 [15122755] J Biol Chem. 2004 May 7;279(19):20108-17 [14978030] Free Radic Biol Med. 2004 Aug 15;37(4):433-41 [15256215] Biochemistry. 2004 Oct 12;43(40):12788-98 [15461451] Am J Hematol. 1985 Jul;19(3):209-18 [3860003] J Cell Biol. 1988 Mar;106(3):761-71 [2450098] J Biol Chem. 1991 Jun 5;266(16):10544-51 [1828073] Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9926-30 [7937919] J Biol Chem. 2003 Jun 13;278(24):21592-600 [12682069] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The role of alcohol consumption in future classifications of alcohol use disorders AN - 57222322; 200717840 AB - Background Item response theory (IRT) was used to determine whether DSM-IV alcohol abuse and dependence and consumption criteria were arrayed along a continuum of severity. Methods Data came from a large, nationally representative sample of the U.S. adult population. Results DSM-IV alcohol abuse and dependence criteria formed a continuum of alcohol use disorder severity along with the drinking 5+/4+ at least once a week in the past year criterion. Criteria were invariant across sex, race-ethnicity, and age subgroups. Conclusion The drinking 5+/4+ high-risk drinking pattern was identified as a suitable criterion for future classifications of DSM-IV alcohol use disorder. Some dependence criteria were among the least severe criteria, and some abuse criteria were among the most severe, findings that question the validity of DSM-IV abuse and dependence categories as distinct entities and that do not support the assumption of abuse as prodromal to dependence. Physical dependence and addiction were identified as defining elements of the continuum. Further research examining their dimensional properties and relationships to high-risk drinking patterns appears warranted. An approach highlighting a more important role of consumption in future classifications of alcohol use disorder defined broadly to encompass all alcohol-related harm, including addiction and physical dependence, is discussed. [Copyright 2006 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Saha, Tulshi D AU - Stinson, Frederick S AU - Grant, Bridget F AD - Laboratory Epidemiology & Biometry, Division Intramural Clinical & Biological Research, National Instit Alcohol Abuse & Alcoholism, National Instit Health, Bethesda, MD Y1 - 2007/06/15/ PY - 2007 DA - 2007 Jun 15 SP - 82 EP - 92 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 89 IS - 1 SN - 0376-8716, 0376-8716 KW - Alcohol use disorder KW - IRT analysis KW - Addiction KW - Physical dependence KW - High-risk drinking patterns KW - Alcohol consumption KW - High risk KW - Severity KW - Item response theory KW - Alcohol related disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57222322?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=The+role+of+alcohol+consumption+in+future+classifications+of+alcohol+use+disorders&rft.au=Saha%2C+Tulshi+D%3BStinson%2C+Frederick+S%3BGrant%2C+Bridget+F&rft.aulast=Saha&rft.aufirst=Tulshi&rft.date=2007-06-15&rft.volume=89&rft.issue=1&rft.spage=82&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2006.12.003 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-09-28 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Alcohol related disorders; Alcohol consumption; Item response theory; Addiction; High risk; Severity DO - http://dx.doi.org/10.1016/j.drugalcdep.2006.12.003 ER - TY - JOUR T1 - Enabling tools for tissue engineering AN - 20634340; 7499059 AB - Tissue engineering is a multidisciplinary field that combines engineering, physical sciences, biology, and medicine to restore or replace tissues and organs functions. In this review, enabling tools for tissue engineering are discussed in the context of four key areas or pillars: prediction, production, performance, and preservation. Prediction refers to the computational modeling where the ability to simulate cellular behavior in complex three-dimensional environments will be essential for design of tissues. Production refer imaging modalities that allow high resolution, non-invasive monitoring of the development and incorporation of tissue engineered constructs. Lastly, preservation includes biochemical tools that permit cryopreservation, vitrification, and freeze-drying of cells and tissues. Recent progress and future perspectives for development in each of these key areas are presented. JF - Biosensors and Bioelectronics AU - Pancrazio, J J AU - Wang, F AU - Kelley, CA AD - 6001 Executive Blvd, Bethesda, MD 20892, United States, pancrazj@ninds.nih.gov Y1 - 2007/06/15/ PY - 2007 DA - 2007 Jun 15 SP - 2803 EP - 2811 PB - Elsevier Advanced Technology, 660 White Plains Rd. Tarrytown NY 10591-5153 USA VL - 22 IS - 12 SN - 0956-5663, 0956-5663 KW - Biotechnology and Bioengineering Abstracts KW - Biosensors KW - Reviews KW - vitrification KW - Freeze-drying KW - Tissue engineering KW - Computer applications KW - Cryopreservation KW - imaging KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20634340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biosensors+and+Bioelectronics&rft.atitle=Enabling+tools+for+tissue+engineering&rft.au=Pancrazio%2C+J+J%3BWang%2C+F%3BKelley%2C+CA&rft.aulast=Pancrazio&rft.aufirst=J&rft.date=2007-06-15&rft.volume=22&rft.issue=12&rft.spage=2803&rft.isbn=&rft.btitle=&rft.title=Biosensors+and+Bioelectronics&rft.issn=09565663&rft_id=info:doi/10.1016%2Fj.bios.2006.12.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Biosensors; Reviews; vitrification; Freeze-drying; Computer applications; Tissue engineering; imaging; Cryopreservation DO - http://dx.doi.org/10.1016/j.bios.2006.12.023 ER - TY - JOUR T1 - Effect of behavioral context on representation of a spatial cue in core auditory cortex of awake macaques. AN - 70605955; 17567810 AB - Primary auditory cortex plays a crucial role in spatially directed behavior, but little is known about the effect of behavioral state on the neural representation of spatial cues. Macaques were trained to discriminate binaural cues to sound localization, eventually allowing measurement of thresholds comparable to human hearing. During behavior and passive listening, single units in low-frequency auditory cortex showed robust and consistent tuning to interaural phase difference (IPD). In most neurons, behavior exerted an effect on peak discharge rate (58% increased, 13% decreased), but this was not accompanied by a detectable shift in the best IPD of any cell. Neurometric analysis revealed a difference in discriminability between the behaving and passive condition in half of the sample (52%), but steepening of the neurometric function (29%) was only slightly more common than flattening (23%). This suggests that performance of a discrimination task does not necessarily confer an advantage in understanding the representation of the spatial cue in primary auditory cortex but nevertheless revealed some physiological effects. These results suggest that responses observed during passive listening provide a valid representation of neuronal response properties in core auditory cortex. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Scott, Brian H AU - Malone, Brian J AU - Semple, Malcolm N AD - Center for Neural Science, New York University, New York, New York 10003, USA. brianscott@mail.nih.gov Y1 - 2007/06/13/ PY - 2007 DA - 2007 Jun 13 SP - 6489 EP - 6499 VL - 27 IS - 24 KW - Index Medicus KW - Auditory Threshold -- physiology KW - Animals KW - Action Potentials -- physiology KW - Discrimination (Psychology) -- physiology KW - Humans KW - Neurons -- physiology KW - Macaca mulatta KW - Dose-Response Relationship, Radiation KW - Acoustic Stimulation -- methods KW - Male KW - Behavior, Animal KW - Auditory Cortex -- cytology KW - Space Perception -- physiology KW - Wakefulness -- physiology KW - Cues KW - Auditory Cortex -- physiology KW - Sound Localization -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70605955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Effect+of+behavioral+context+on+representation+of+a+spatial+cue+in+core+auditory+cortex+of+awake+macaques.&rft.au=Scott%2C+Brian+H%3BMalone%2C+Brian+J%3BSemple%2C+Malcolm+N&rft.aulast=Scott&rft.aufirst=Brian&rft.date=2007-06-13&rft.volume=27&rft.issue=24&rft.spage=6489&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-19 N1 - Date created - 2007-06-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death. AN - 70616178; 17560373 AB - Tumor necrosis factor (TNF) is an important cytokine in immunity and inflammation and induces many cellular responses, including apoptosis and necrosis. TNF signaling enables the generation of superoxide in phagocytic and vascular cells through the activation of the NADPH oxidase Nox2/gp91. Here we show that TNF also activates the Nox1 NADPH oxidase in mouse fibroblasts when cells undergo necrosis. TNF treatment induces the formation of a signaling complex containing TRADD, RIP1, Nox1, and the small GTPase Rac1. TNF-treated RIP1-deficient fibroblasts fail to form such a complex, indicating that RIP1 is essential for Nox1 recruitment. Moreover, the prevention of TNF-induced superoxide generation with dominant-negative mutants of TRADD or Rac1, as well as knockdown of Nox1 using siRNA, inhibits necrosis. Thus our study suggests that activation of Nox1 through forming a complex with TNF signaling components plays a key role in TNF-induced necrotic cell death. JF - Molecular cell AU - Kim, You-Sun AU - Morgan, Michael J AU - Choksi, Swati AU - Liu, Zheng-Gang AD - Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/06/08/ PY - 2007 DA - 2007 Jun 08 SP - 675 EP - 687 VL - 26 IS - 5 SN - 1097-2765, 1097-2765 KW - Antioxidants KW - 0 KW - GTPase-Activating Proteins KW - Multiprotein Complexes KW - Neuropeptides KW - RNA, Small Interfering KW - Rac1 protein, mouse KW - Ralbp1 protein, mouse KW - TNF Receptor-Associated Death Domain Protein KW - Tradd protein, mouse KW - Tumor Necrosis Factor-alpha KW - Superoxides KW - 11062-77-4 KW - Butylated Hydroxyanisole KW - 25013-16-5 KW - NADH, NADPH Oxidoreductases KW - EC 1.6.- KW - NADPH oxidase 1 KW - EC 1.6.99.- KW - rac GTP-Binding Proteins KW - EC 3.6.5.2 KW - rac1 GTP-Binding Protein KW - Index Medicus KW - rac GTP-Binding Proteins -- metabolism KW - Animals KW - Humans KW - RNA, Small Interfering -- genetics KW - Mice KW - Neuropeptides -- metabolism KW - TNF Receptor-Associated Death Domain Protein -- metabolism KW - rac GTP-Binding Proteins -- chemistry KW - Superoxides -- metabolism KW - GTPase-Activating Proteins -- chemistry KW - Necrosis KW - GTPase-Activating Proteins -- metabolism KW - Antioxidants -- pharmacology KW - TNF Receptor-Associated Death Domain Protein -- chemistry KW - Neuropeptides -- chemistry KW - Signal Transduction KW - Butylated Hydroxyanisole -- pharmacology KW - Cell Line KW - Cell Death -- physiology KW - NADH, NADPH Oxidoreductases -- genetics KW - NADH, NADPH Oxidoreductases -- chemistry KW - Tumor Necrosis Factor-alpha -- pharmacology KW - NADH, NADPH Oxidoreductases -- metabolism KW - Cell Death -- drug effects KW - NADH, NADPH Oxidoreductases -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70616178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cell&rft.atitle=TNF-induced+activation+of+the+Nox1+NADPH+oxidase+and+its+role+in+the+induction+of+necrotic+cell+death.&rft.au=Kim%2C+You-Sun%3BMorgan%2C+Michael+J%3BChoksi%2C+Swati%3BLiu%2C+Zheng-Gang&rft.aulast=Kim&rft.aufirst=You-Sun&rft.date=2007-06-08&rft.volume=26&rft.issue=5&rft.spage=675&rft.isbn=&rft.btitle=&rft.title=Molecular+cell&rft.issn=10972765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-17 N1 - Date created - 2007-06-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Mol Cell. 2007 Jun 22;26(6):769-71 [17588511] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Site-specific mutations in HIV-1 gp41 reveal a correlation between HIV-1-mediated bystander apoptosis and fusion/hemifusion. AN - 70571922; 17416587 AB - The loss of CD4(+) T cells in HIV-1 infections is hypothesized to be caused by apoptosis of bystander cells mediated by cell surface-expressed HIV-1 Env glycoprotein. However, the mechanism by which Env mediates this process remains controversial. Specifically, the role of HIV-1 gp120 binding to CD4 and CXCR4 versus the fusion process mediated by gp41 remains unresolved. Env-induced apoptosis in bystander cells has been shown to be gp41-dependent and correlates with the redistribution of membrane lipids between Env-expressing cells and target cells (hemifusion). Using a rational mutagenesis approach aimed at targeting Env function via the gp41 subunit, we examined the role of HIV gp41 in bystander apoptosis. A mutation in the fusion domain of gp41 (V513E) resulted in a fusion-defective Env that failed to induce apoptosis. A mutation in the gp41 N-terminal helix (G547D) reduced cell fusion capacity and apoptosis; conversely, an Env mutant with a deletion of the gp41 cytoplasmic tail (Ct Del) enhanced both cell-to-cell fusion and apoptosis. Most significantly, an Env mutant containing a substitution in the loop region of gp41 (D589L) mediated transfer of lipids (hemifusion) to bystander cells but was defective in cell-to-cell and to a lesser degree virus-to-cell fusion. This mutant was still able to induce apoptosis in bystander cells. Hence, we have provided the first direct evidence that gp41-mediated hemifusion is both required and sufficient for induction of apoptosis in bystander cells. These results may help to explain the mechanism of HIV-1 Env-induced T cell depletion. JF - The Journal of biological chemistry AU - Garg, Himanshu AU - Joshi, Anjali AU - Freed, Eric O AU - Blumenthal, Robert AD - Membrane Structure and Function Section, Center for Cancer Research Nanobiology Program, NCI, National Institutes of Health, Frederick, Maryland 21702, USA. Y1 - 2007/06/08/ PY - 2007 DA - 2007 Jun 08 SP - 16899 EP - 16906 VL - 282 IS - 23 SN - 0021-9258, 0021-9258 KW - Caspase Inhibitors KW - 0 KW - Cysteine Proteinase Inhibitors KW - HIV Envelope Protein gp41 KW - Reverse Transcriptase Inhibitors KW - Nelfinavir KW - HO3OGH5D7I KW - Index Medicus KW - Virus Replication KW - Mutagenesis, Site-Directed KW - Cysteine Proteinase Inhibitors -- pharmacology KW - Reverse Transcriptase Inhibitors -- pharmacology KW - HeLa Cells KW - Humans KW - Nelfinavir -- pharmacology KW - Membrane Fusion -- physiology KW - HIV Envelope Protein gp41 -- genetics KW - Apoptosis -- drug effects KW - HIV-1 -- physiology KW - HIV Envelope Protein gp41 -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70571922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Site-specific+mutations+in+HIV-1+gp41+reveal+a+correlation+between+HIV-1-mediated+bystander+apoptosis+and+fusion%2Fhemifusion.&rft.au=Garg%2C+Himanshu%3BJoshi%2C+Anjali%3BFreed%2C+Eric+O%3BBlumenthal%2C+Robert&rft.aulast=Garg&rft.aufirst=Himanshu&rft.date=2007-06-08&rft.volume=282&rft.issue=23&rft.spage=16899&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-10 N1 - Date created - 2007-06-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Replicating genotype-phenotype associations AN - 204571585; 17554299 AB - The study of human genetics has recently undergone a dramatic transition with the completion of both the sequencing of the human genome and the mapping of human haplo-types of the most common form of genetic variation, the single nucleotide polymorphism (SNP)13. Chanock et al present the conclusions of a working group on the replication of genotype-phenotype associations whether identified in genome-wide or candidate-gene studies convened by the National Cancer Institute and the National Human Genome Research Institute with the purpose to review the current state of the field and propose best practices for the design, conduct and publication of replication studies that aim to follow up notable findings, particularly in genome-wide association studies. JF - Nature AU - Chanock, Stephen J AU - Manolio, Teri AU - Boehnke, Michael AU - Boerwinkle, Eric AU - Hunter, David J AU - Thomas, Gilles AU - Hirschhorn, Joel N AU - Abecasis, Goncalo AU - Altshuler, David AU - Bailey-Wilson, Joan E AU - Brooks, Lisa D AU - Cardon, Lon R AU - Daly, Mark AU - Donnelly, Peter Y1 - 2007/06/07/ PY - 2007 DA - 2007 Jun 07 SP - 655 EP - 60 CY - London PB - Nature Publishing Group VL - 447 IS - 7145 SN - 00280836 KW - Environmental Studies KW - Genetics KW - Genomics KW - Genotype & phenotype KW - Research KW - Phenotype KW - Genotype KW - Haplotypes -- genetics KW - Reproducibility of Results KW - Humans KW - Peer Review, Research -- standards KW - Polymorphism, Single Nucleotide -- genetics KW - Genetic Predisposition to Disease -- genetics KW - Genome, Human -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/204571585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Replicating+genotype-phenotype+associations&rft.au=Chanock%2C+Stephen+J%3BManolio%2C+Teri%3BBoehnke%2C+Michael%3BBoerwinkle%2C+Eric%3BHunter%2C+David+J%3BThomas%2C+Gilles%3BHirschhorn%2C+Joel+N%3BAbecasis%2C+Goncalo%3BAltshuler%2C+David%3BBailey-Wilson%2C+Joan+E%3BBrooks%2C+Lisa+D%3BCardon%2C+Lon+R%3BDaly%2C+Mark%3BDonnelly%2C+Peter&rft.aulast=Chanock&rft.aufirst=Stephen&rft.date=2007-06-07&rft.volume=447&rft.issue=7145&rft.spage=655&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/10.1038%2F447655a LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright Nature Publishing Group Jun 7, 2007 N1 - Document feature - References N1 - Last updated - 2014-03-31 N1 - CODEN - NATUAS DO - http://dx.doi.org/10.1038/447655a ER - TY - JOUR T1 - Newcastle disease virus, a host range-restricted virus, as a vaccine vector for intranasal immunization against emerging pathogens AN - 20262661; 7464650 AB - The international outbreak of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) in 2002-2003 highlighted the need to develop pretested human vaccine vectors that can be used in a rapid response against newly emerging pathogens. We evaluated Newcastle disease virus (NDV), an avian paramyxovirus that is highly attenuated in primates, as a topical respiratory vaccine vector with SARS-CoV as a test pathogen. Complete recombinant NDV was engineered to express the SARS-CoV spike S glycoprotein, the viral neutralization and major protective antigen, from an added transcriptional unit. African green monkeys immunized through the respiratory tract with two doses of the vaccine developed a titer of SARS-CoV-neutralizing antibodies comparable with the robust secondary response observed in animals that have been immunized with a different experimental SARS-CoV vaccine and challenged with SARS-CoV. When animals immunized with NDV expressing S were challenged with a high dose of SARS-CoV, direct viral assay of lung tissues taken by necropsy at the peak of viral replication demonstrated a 236- or 1,102-fold (depending on the NDV vector construct) mean reduction in pulmonary SARS-CoV titer compared with control animals. NDV has the potential for further development as a pretested, highly attenuated, intranasal vector to be available for expedited vaccine development for humans, who generally lack preexisting immunity against NDV. JF - Proceedings of the National Academy of Sciences, USA AU - DiNapoli, Joshua M AU - Kotelkin, Alexander AU - Yang, Lijuan AU - Elankumaran, Subbiah AU - Murphy, Brian R AU - Samal, Siba K AU - Collins, Peter L AU - Bukreyev, Alexander AD - Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 Y1 - 2007/06/05/ PY - 2007 DA - 2007 Jun 05 SP - 9788 EP - 9793 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 23 SN - 0027-8424, 0027-8424 KW - Primates KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - Newcastle disease KW - Newcastle disease virus KW - Glycoproteins KW - Respiratory tract KW - Replication KW - Vectors KW - Transcription KW - Immunity KW - Immunization KW - Vaccines KW - SARS coronavirus KW - Autopsy KW - Coronavirus KW - protective antigen KW - Paramyxovirus KW - Pathogens KW - Antibodies KW - Lung KW - F 06905:Vaccines KW - V 22350:Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20262661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Newcastle+disease+virus%2C+a+host+range-restricted+virus%2C+as+a+vaccine+vector+for+intranasal+immunization+against+emerging+pathogens&rft.au=DiNapoli%2C+Joshua+M%3BKotelkin%2C+Alexander%3BYang%2C+Lijuan%3BElankumaran%2C+Subbiah%3BMurphy%2C+Brian+R%3BSamal%2C+Siba+K%3BCollins%2C+Peter+L%3BBukreyev%2C+Alexander&rft.aulast=DiNapoli&rft.aufirst=Joshua&rft.date=2007-06-05&rft.volume=104&rft.issue=23&rft.spage=9788&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - SARS coronavirus; Newcastle disease virus; Paramyxovirus; Coronavirus; Primates; Vaccines; Pathogens; Newcastle disease; Lung; Respiratory tract; Replication; Autopsy; protective antigen; Transcription; Antibodies; Immunity; Glycoproteins; Immunization; Vectors ER - TY - JOUR T1 - Neuroimaging of neuronal circuits involved in tic generation in patients with Tourette syndrome AN - 19575010; 8861970 AB - Objective: To identify brain regions generating tics in patients with Tourette syndrome using sleep as a baseline. Methods: We used [ super(15)O]H sub(2)O PET to study nine patients with Tourette syndrome and nine matched control subjects. For patients, conditions included tic release states and sleep stage 2; and for control subjects, rest states and sleep stage 2. Results: Our study showed robust activation of cerebellum, insula, thalamus, and putamen during tic release. Conclusion: The network of structures involved in tics includes the activated regions and motor cortex. The prominent involvement of cerebellum and insula suggest their involvement in tic initiation and execution. JF - Neurology AU - Lerner, A AU - Bagic, A AU - Boudreau, E A AU - Hanakawa, T AU - Pagan, F AU - Mari, Z AU - Bara-Jimenez, W AU - Aksu, M AU - Garraux, G AU - Simmons, J M AU - Sato, S AU - Murphy, D L AU - Hallett, M AD - Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 31 Center Drive MSC 2035, Bldg. 31, Room B2-B34, Betbesda, MD 20892-2035, USA, lernera@mail.nih.gov Y1 - 2007/06/05/ PY - 2007 DA - 2007 Jun 05 SP - 1979 EP - 1987 VL - 68 IS - 23 SN - 0028-3878, 0028-3878 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Neuroimaging KW - Cortex (motor) KW - Sleep KW - Cerebellum KW - Positron emission tomography KW - Circuits KW - Gilles de la Tourette syndrome KW - Thalamus KW - Putamen KW - W 30965:Miscellaneous, Reviews KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19575010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Neuroimaging+of+neuronal+circuits+involved+in+tic+generation+in+patients+with+Tourette+syndrome&rft.au=Lerner%2C+A%3BBagic%2C+A%3BBoudreau%2C+E+A%3BHanakawa%2C+T%3BPagan%2C+F%3BMari%2C+Z%3BBara-Jimenez%2C+W%3BAksu%2C+M%3BGarraux%2C+G%3BSimmons%2C+J+M%3BSato%2C+S%3BMurphy%2C+D+L%3BHallett%2C+M&rft.aulast=Lerner&rft.aufirst=A&rft.date=2007-06-05&rft.volume=68&rft.issue=23&rft.spage=1979&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=00283878&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cortex (motor); Neuroimaging; Sleep; Positron emission tomography; Cerebellum; Circuits; Putamen; Thalamus; Gilles de la Tourette syndrome ER - TY - JOUR T1 - Myofibroblastic tumor of the lower lip in a patient with X-linked hypogammaglobulinemia and isolated growth hormone deficiency: a case report. AN - 85411760; pmid-17517309 JF - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons AU - Imanguli, Matin M AU - Karai, Laszlo J AU - Shanti, Rabie M AU - Stewart, Donn M AU - Brahim, Jaime S AD - Clinical Research Cores, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. mimanguli@mail.nih.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1219 EP - 1222 VL - 65 IS - 6 SN - 0278-2391, 0278-2391 KW - National Library of Medicine KW - Adult KW - *Agammaglobulinemia: genetics KW - Diagnosis, Differential KW - *Human Growth Hormone: deficiency KW - Humans KW - *Lip Neoplasms: diagnosis KW - Lip Neoplasms: pathology KW - Male KW - *Neoplasms, Muscle Tissue: diagnosis KW - Neoplasms, Muscle Tissue: pathology KW - Salivary Gland Neoplasms: diagnosis KW - *X-Linked Combined Immunodeficiency Diseases: genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85411760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+oral+and+maxillofacial+surgery+%3A+official+journal+of+the+American+Association+of+Oral+and+Maxillofacial+Surgeons&rft.atitle=Myofibroblastic+tumor+of+the+lower+lip+in+a+patient+with+X-linked+hypogammaglobulinemia+and+isolated+growth+hormone+deficiency%3A+a+case+report.&rft.au=Imanguli%2C+Matin+M%3BKarai%2C+Laszlo+J%3BShanti%2C+Rabie+M%3BStewart%2C+Donn+M%3BBrahim%2C+Jaime+S&rft.aulast=Imanguli&rft.aufirst=Matin&rft.date=2007-06-01&rft.volume=65&rft.issue=6&rft.spage=1219&rft.isbn=&rft.btitle=&rft.title=Journal+of+oral+and+maxillofacial+surgery+%3A+official+journal+of+the+American+Association+of+Oral+and+Maxillofacial+Surgeons&rft.issn=02782391&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Metabolic regulation of citrate and iron by aconitases: role of iron-sulfur cluster biogenesis AN - 822522132; 13770345 AB - Iron and citrate are essential for the metabolism of most organisms, and regulation of iron and citrate biology at both the cellular and systemic levels is critical for normal physiology and survival. Mitochondrial and cytosolic aconitases catalyze the interconversion of citrate and isocitrate, and aconitase activities are affected by iron levels, oxidative stress and by the status of the Fe-S cluster biogenesis apparatus. Assembly and disassembly of Fe-S clusters is a key process not only in regulating the enzymatic activity of mitochondrial aconitase in the citric acid cycle, but also in controlling the iron sensing and RNA binding activities of cytosolic aconitase (also known as iron regulatory protein IRP1). This review discusses the central role of aconitases in intermediary metabolism and explores how iron homeostasis and Fe-S cluster biogenesis regulate the Fe-S cluster switch and modulate intracellular citrate flux. JF - BioMetals AU - Tong, Wing-Hang AU - Rouault, Tracey A AD - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, NIH Bldg 18, Rm 101, Bethesda, MD, 20892, USA, trou@helix.nih.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 549 EP - 564 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 20 IS - 3-4 SN - 0966-0844, 0966-0844 KW - Toxicology Abstracts KW - Cell survival KW - Mitochondria KW - Homeostasis KW - Iron regulatory protein KW - RNA KW - Oxidative stress KW - Enzymatic activity KW - Tricarboxylic acid cycle KW - Iron KW - Aconitate hydratase KW - Metabolism KW - Citric acid KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/822522132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioMetals&rft.atitle=Metabolic+regulation+of+citrate+and+iron+by+aconitases%3A+role+of+iron-sulfur+cluster+biogenesis&rft.au=Tong%2C+Wing-Hang%3BRouault%2C+Tracey+A&rft.aulast=Tong&rft.aufirst=Wing-Hang&rft.date=2007-06-01&rft.volume=20&rft.issue=3-4&rft.spage=549&rft.isbn=&rft.btitle=&rft.title=BioMetals&rft.issn=09660844&rft_id=info:doi/10.1007%2Fs10534-006-9047-6 LA - Dutch DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-06-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Cell survival; RNA; Oxidative stress; Mitochondria; Enzymatic activity; Homeostasis; Tricarboxylic acid cycle; Iron regulatory protein; Aconitate hydratase; Iron; Metabolism; Citric acid DO - http://dx.doi.org/10.1007/s10534-006-9047-6 ER - TY - JOUR T1 - Phase I Trial of an Enhanced Prostate-Specific Antigen-Based Vaccine and Anti-CTLA-4 Antibody in Patients with Metastatic Androgen-Independent Prostate Cancer AN - 754901816; 13553099 JF - Clinical Genitourinary Cancer AU - Theoret, M R AU - Arlen, P M AU - Pazdur, M AU - Dahut, W L AU - Schlom, J AU - Gulley, J L AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 347 EP - 350 VL - 5 IS - 5 SN - 1558-7673, 1558-7673 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Metastases KW - Antibodies KW - Prostate cancer KW - Vaccines KW - Clinical trials KW - F 06915:Cancer Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754901816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Genitourinary+Cancer&rft.atitle=Phase+I+Trial+of+an+Enhanced+Prostate-Specific+Antigen-Based+Vaccine+and+Anti-CTLA-4+Antibody+in+Patients+with+Metastatic+Androgen-Independent+Prostate+Cancer&rft.au=Theoret%2C+M+R%3BArlen%2C+P+M%3BPazdur%2C+M%3BDahut%2C+W+L%3BSchlom%2C+J%3BGulley%2C+J+L&rft.aulast=Theoret&rft.aufirst=M&rft.date=2007-06-01&rft.volume=5&rft.issue=5&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=Clinical+Genitourinary+Cancer&rft.issn=15587673&rft_id=info:doi/10.3816%2FCGC.2007.n.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2011-12-15 N1 - SubjectsTermNotLitGenreText - Metastases; Antibodies; Prostate cancer; Vaccines; Clinical trials DO - http://dx.doi.org/10.3816/CGC.2007.n.017 ER - TY - JOUR T1 - Inorganic Arsenic in Drinking Water: An Evolving Public Health Concern AN - 744581654; 7463567 JF - Journal of the National Cancer Institute AU - Lubin, Jay H AU - Beane Freeman, Laura E AU - Cantor, Kenneth P AD - Biostatistics Branch (JHL) and Occupational and Environmental Epidemiology Branch (LEBF, KPC), Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 906 EP - 907 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 12 SN - 0027-8874, 0027-8874 KW - Pollution Abstracts KW - Arsenic KW - Drinking water KW - Cancer KW - Public health KW - P 2000:FRESHWATER POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/744581654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Inorganic+Arsenic+in+Drinking+Water%3A+An+Evolving+Public+Health+Concern&rft.au=Lubin%2C+Jay+H%3BBeane+Freeman%2C+Laura+E%3BCantor%2C+Kenneth+P&rft.aulast=Lubin&rft.aufirst=Jay&rft.date=2007-06-01&rft.volume=99&rft.issue=12&rft.spage=906&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-04-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Arsenic; Drinking water; Cancer; Public health ER - TY - JOUR T1 - Cetuximab/targeted chemotherapy in an HIV-positive patient with metastatic colorectal cancer in the HAART era: a case report. AN - 70627075; 17594933 AB - Recent data have shown the efficacy of cetuximab/Folfiri regimen in patients with chemotherapy-resistant metastatic colorectal cancer. In the literature there are no data about this treatment in HIV-positive patients with metastatic colorectal cancer. At the Aviano Cancer Center, we used the cetuximab/Folfiri regimen and concomitant HAART in an HIV-positive patient with metastatic colorectal cancer. The patient experienced acceptable non-hematological toxicity, without any opportunistic infection and his HIV infection was kept under control. This case suggests that, in the HAART era, a multidisciplinary approach can be offered to HIV patients with advanced cancer when they have good performance status, resulting in efficacious control of the HIV infection. JF - Journal of chemotherapy (Florence, Italy) AU - Berretta, M AU - Martellotta, F AU - Simonelli, C AU - Di Benedetto, F AU - De Ruvo, N AU - Drigo, A AU - Bearz, A AU - Spina, M AU - Zanet, E AU - Berretta, S AU - Tirelli, U AD - Division of Medical Oncology A, National Cancer Institute, Aviano, Italy. Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 343 EP - 346 VL - 19 IS - 3 SN - 1120-009X, 1120-009X KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Cetuximab KW - PQX0D8J21J KW - Leucovorin KW - Q573I9DVLP KW - Fluorouracil KW - U3P01618RT KW - Camptothecin KW - XT3Z54Z28A KW - Index Medicus KW - Humans KW - Leucovorin -- administration & dosage KW - Camptothecin -- therapeutic use KW - Antibodies, Monoclonal -- administration & dosage KW - Camptothecin -- administration & dosage KW - Fluorouracil -- administration & dosage KW - Fluorouracil -- therapeutic use KW - Neoplasm Metastasis KW - Camptothecin -- analogs & derivatives KW - Middle Aged KW - Female KW - Leucovorin -- therapeutic use KW - Colorectal Neoplasms -- complications KW - HIV Infections -- complications KW - Colorectal Neoplasms -- pathology KW - HIV Infections -- drug therapy KW - Antiretroviral Therapy, Highly Active KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Colorectal Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70627075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chemotherapy+%28Florence%2C+Italy%29&rft.atitle=Cetuximab%2Ftargeted+chemotherapy+in+an+HIV-positive+patient+with+metastatic+colorectal+cancer+in+the+HAART+era%3A+a+case+report.&rft.au=Berretta%2C+M%3BMartellotta%2C+F%3BSimonelli%2C+C%3BDi+Benedetto%2C+F%3BDe+Ruvo%2C+N%3BDrigo%2C+A%3BBearz%2C+A%3BSpina%2C+M%3BZanet%2C+E%3BBerretta%2C+S%3BTirelli%2C+U&rft.aulast=Berretta&rft.aufirst=M&rft.date=2007-06-01&rft.volume=19&rft.issue=3&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=Journal+of+chemotherapy+%28Florence%2C+Italy%29&rft.issn=1120009X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-26 N1 - Date created - 2007-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chronic lymphocytic leukemia-associated autoimmune hemolytic anemia. AN - 70620369; 17577769 AB - The clinical course of patients with B-cell chronic lymphocytic leukemia (CLL) is often made complicated by autoimmune phenomena which mainly target the blood cells. Among them, the autoimmune hemolytic anemia (AIHA) is the most common form. On the other hand, it is believed that CLL is the most common of the known causes of AIHA. The source of any putative autoantibody (bystander nonmalignant cells or tumor cells) is not clear yet. Recently, it has been hypothesized that leukemic B-cells may also act as professional antigen presenting cells (APCs). With respect to the management of CLL-associated AIHA, steroids still represent the first-line treatment option. Intravenous immunoglobulin, immunosuppressive drugs, and splenectomy are also frequently used for steroid-refractory forms. Furthermore, although the case series is still too small, encouraging data is now supporting the use of monoclonal antibodies, in particular anti-CD20 rituximab, in managing this often life-threatening autoimmune complication of CLL. JF - Leukemia & lymphoma AU - D'Arena, Giovanni AU - Cascavilla, Nicola AD - Hematology Oncology and Bone Marrow Transplantation Unit, National Cancer Institute, IRCCS Fondazione "G. Pascale", Naples, Italy. giovannidarena@libero.it Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 1072 EP - 1080 VL - 48 IS - 6 SN - 1042-8194, 1042-8194 KW - Antineoplastic Agents KW - 0 KW - Vidarabine KW - FA2DM6879K KW - fludarabine KW - P2K93U8740 KW - Index Medicus KW - Vidarabine -- analogs & derivatives KW - Humans KW - Vidarabine -- therapeutic use KW - Antineoplastic Agents -- therapeutic use KW - Vidarabine -- adverse effects KW - Models, Biological KW - Antineoplastic Agents -- adverse effects KW - Anemia, Hemolytic, Autoimmune -- therapy KW - Leukemia, Lymphocytic, Chronic, B-Cell -- etiology KW - Anemia, Hemolytic, Autoimmune -- chemically induced KW - Leukemia, Lymphocytic, Chronic, B-Cell -- complications KW - Leukemia, Lymphocytic, Chronic, B-Cell -- therapy KW - Anemia, Hemolytic, Autoimmune -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70620369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia+%26+lymphoma&rft.atitle=Chronic+lymphocytic+leukemia-associated+autoimmune+hemolytic+anemia.&rft.au=D%27Arena%2C+Giovanni%3BCascavilla%2C+Nicola&rft.aulast=D%27Arena&rft.aufirst=Giovanni&rft.date=2007-06-01&rft.volume=48&rft.issue=6&rft.spage=1072&rft.isbn=&rft.btitle=&rft.title=Leukemia+%26+lymphoma&rft.issn=10428194&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-28 N1 - Date created - 2007-06-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Therapeutic immunotoxins for lymphoid malignancies: the end of the beginning. AN - 70614807; 17577767 JF - Leukemia & lymphoma AU - Morris, John C AU - Janik, John E AD - Clinical Trials, Metabolism Branch, Center for Cancer Research, National Cancer Institute, Mark O. Hatfield Clinical Research Center, Bethesda, MD 20892, USA. jmorris@mail.nih.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 1067 EP - 1069 VL - 48 IS - 6 SN - 1042-8194, 1042-8194 KW - Immunotoxins KW - 0 KW - Index Medicus KW - Animals KW - Clinical Trials, Phase I as Topic -- trends KW - Humans KW - Drug Evaluation, Preclinical KW - Lymphoproliferative Disorders -- drug therapy KW - Immunotoxins -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70614807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia+%26+lymphoma&rft.atitle=Therapeutic+immunotoxins+for+lymphoid+malignancies%3A+the+end+of+the+beginning.&rft.au=Morris%2C+John+C%3BJanik%2C+John+E&rft.aulast=Morris&rft.aufirst=John&rft.date=2007-06-01&rft.volume=48&rft.issue=6&rft.spage=1067&rft.isbn=&rft.btitle=&rft.title=Leukemia+%26+lymphoma&rft.issn=10428194&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-28 N1 - Date created - 2007-06-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Leuk Lymphoma. 2007 Jun;48(6):1179-86 [17577782] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Safety, tolerability, and pharmacokinetics of high-dose idebenone in patients with Friedreich ataxia. AN - 70613475; 17562928 AB - Friedreich ataxia (FA) is a progressive, multisystem degenerative disorder in which oxidative stress is believed to have a role. Recent clinical studies indicate that the antioxidant idebenone, administered at 5 mg/kg per day, reduces the cardiac hypertrophy that occurs in FA, but improvement in neurologic measures is unclear. Some studies suggest that higher doses of idebenone may be more effective, but pharmacology and toxicology at higher doses have not been investigated in human beings. To determine the safety, tolerability, and pharmacokinetics of increasing doses of idebenone in subjects with FA. Open-label, phase 1A dose-escalation trial followed by an open-label, 1-month phase 1B trial. National Institutes of Health Clinical Center, Bethesda, Md. Phase 1A included 78 subjects with FA (24 adults, 27 adolescents, and 27 children), and phase 1B included 15 subjects with FA (5 adults, 5 adolescents, and 5 children). Oral idebenone was administered to groups of 3 subjects in each age cohort during day 1. In phase 1A, the dose was increased in 10-mg/kg increments in each successive dose group to a maximum of 75 mg/kg. In phase 1B, oral idebenone was administered at 60 mg/kg divided in 3 doses per day for 1 month. We studied the type, number, and frequency of adverse events, and pharmacokinetic parameters including maximum drug concentration, time to maximum drug concentration, area under the curve, and half-life. In the first phase of the study, no dose-limiting toxicity was observed and the maximum allowed dose of 75 mg/kg was achieved in all cohorts. Plasma levels of total idebenone were found to increase proportional to drug dose up to 55 mg/kg. Variability in absorption of the drug was observed, but drug half-life was relatively consistent across dose levels. In the second phase of the study, 14 of 15 subjects with FA tolerated idebenone at a dose of 60 mg/kg per day for 1 month. All adverse events were mild, and pharmacokinetic parameters including maximum drug concentration, time to maximum drug concentration, and half-life did not differ significantly across age cohorts. These findings indicate that higher doses of idebenone lead to a proportional increase in plasma levels up to 55 mg/kg per day and that high-dose idebenone is well-tolerated in patients with FA. These findings are essential to planning efficacy trials of high-dose idebenone in FA and other degenerative diseases in which oxidative damage has been implicated. JF - Archives of neurology AU - Di Prospero, Nicholas A AU - Sumner, Charlotte J AU - Penzak, Scott R AU - Ravina, Bernard AU - Fischbeck, Kenneth H AU - Taylor, J Paul AD - Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-3705, USA. diprospern@ninds.nih.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 803 EP - 808 VL - 64 IS - 6 SN - 0003-9942, 0003-9942 KW - Antioxidants KW - 0 KW - Benzoquinones KW - Ubiquinone KW - 1339-63-5 KW - idebenone KW - HB6PN45W4J KW - Abridged Index Medicus KW - Index Medicus KW - Administration, Oral KW - Osmolar Concentration KW - Dose-Response Relationship, Drug KW - Humans KW - Child KW - Ubiquinone -- analogs & derivatives KW - Half-Life KW - Adult KW - Absorption KW - Adolescent KW - Time Factors KW - Female KW - Male KW - Benzoquinones -- therapeutic use KW - Friedreich Ataxia -- blood KW - Antioxidants -- adverse effects KW - Friedreich Ataxia -- drug therapy KW - Benzoquinones -- adverse effects KW - Benzoquinones -- blood KW - Antioxidants -- therapeutic use KW - Antioxidants -- pharmacokinetics KW - Benzoquinones -- administration & dosage KW - Antioxidants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70613475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+neurology&rft.atitle=Safety%2C+tolerability%2C+and+pharmacokinetics+of+high-dose+idebenone+in+patients+with+Friedreich+ataxia.&rft.au=Di+Prospero%2C+Nicholas+A%3BSumner%2C+Charlotte+J%3BPenzak%2C+Scott+R%3BRavina%2C+Bernard%3BFischbeck%2C+Kenneth+H%3BTaylor%2C+J+Paul&rft.aulast=Di+Prospero&rft.aufirst=Nicholas&rft.date=2007-06-01&rft.volume=64&rft.issue=6&rft.spage=803&rft.isbn=&rft.btitle=&rft.title=Archives+of+neurology&rft.issn=00039942&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-17 N1 - Date created - 2007-06-12 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - NCT00078481; ClinicalTrials.gov; NCT00015808 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Structural basis for dimerization of LAP2alpha, a component of the nuclear lamina. AN - 70610352; 17562312 AB - Lamina-associated polypeptides (LAPs) are important components of the nuclear lamina, the dense network of filaments that supports the nuclear envelope and also extends into the nucleoplasm. The main protein constituents of the nuclear lamina are the constitutively expressed B-type lamins and the developmentally regulated A- and C-type lamins. LAP2alpha is the only non-membrane-associated member of the LAP family. It preferentially binds lamin A/C, has been implicated in cell-cycle regulation and chromatin organization, and has also been found to be a component of retroviral preintegration complexes. As an approach to understanding the role of LAP2alpha in cellular pathways, we have determined the crystal structure of the C-terminal domain of LAP2alpha, residues 459-693. The C-terminal domain is dimeric and possesses an extensive four-stranded, antiparallel coiled coil. The surface involved in binding lamin A/C is proposed based on results from alanine-scanning mutagenesis and a solid-phase overlay binding assay. JF - Structure (London, England : 1993) AU - Bradley, Christina Marchetti AU - Jones, Sarah AU - Huang, Ying AU - Suzuki, Youichi AU - Kvaratskhelia, Mamuka AU - Hickman, Alison Burgess AU - Craigie, Robert AU - Dyda, Fred AD - Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 643 EP - 653 VL - 15 IS - 6 SN - 0969-2126, 0969-2126 KW - DNA-Binding Proteins KW - 0 KW - Lamin Type A KW - Membrane Proteins KW - Nuclear Proteins KW - lamin C KW - lamina-associated polypeptide 2 KW - Index Medicus KW - Animals KW - Protein Structure, Secondary KW - Models, Molecular KW - Dimerization KW - Lamin Type A -- metabolism KW - Amino Acid Sequence KW - Mice KW - Protein Binding KW - NIH 3T3 Cells KW - Binding Sites KW - Transfection KW - Molecular Sequence Data KW - Point Mutation KW - Protein Structure, Tertiary KW - Nuclear Proteins -- genetics KW - Nuclear Lamina -- chemistry KW - DNA-Binding Proteins -- chemistry KW - Membrane Proteins -- chemistry KW - Membrane Proteins -- metabolism KW - DNA-Binding Proteins -- genetics KW - Nuclear Proteins -- chemistry KW - Membrane Proteins -- genetics KW - DNA-Binding Proteins -- isolation & purification KW - Nuclear Proteins -- metabolism KW - Membrane Proteins -- isolation & purification KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70610352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Structure+%28London%2C+England+%3A+1993%29&rft.atitle=Structural+basis+for+dimerization+of+LAP2alpha%2C+a+component+of+the+nuclear+lamina.&rft.au=Bradley%2C+Christina+Marchetti%3BJones%2C+Sarah%3BHuang%2C+Ying%3BSuzuki%2C+Youichi%3BKvaratskhelia%2C+Mamuka%3BHickman%2C+Alison+Burgess%3BCraigie%2C+Robert%3BDyda%2C+Fred&rft.aulast=Bradley&rft.aufirst=Christina&rft.date=2007-06-01&rft.volume=15&rft.issue=6&rft.spage=643&rft.isbn=&rft.btitle=&rft.title=Structure+%28London%2C+England+%3A+1993%29&rft.issn=09692126&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-02 N1 - Date created - 2007-06-12 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 2V0X; PDB N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inhibition of ABCG2-mediated transport by protein kinase inhibitors with a bisindolylmaleimide or indolocarbazole structure. AN - 70608799; 17575116 AB - ABCG2 is a transporter with potential importance in cancer drug resistance, drug oral absorption, and stem cell biology. In an effort to identify novel inhibitors of ABCG2, we examined the ability of commercially available bisindolylmaleimides (BIM) and indolocarbazole protein kinase inhibitors (PKI) to inhibit ABCG2, given the previous demonstration that the indolocarbazole PKI UCN-01 interacted with the transporter. At a concentration of 10 micromol/L, all of the compounds tested increased intracellular fluorescence of the ABCG2-specific substrate pheophorbide a in ABCG2-transfected HEK-293 cells by 1.3- to 6-fold as measured by flow cytometry; the ABCG2-specific inhibitor fumitremorgin C increased intracellular fluorescence by 6.6-fold. In 4-day cytotoxicity assays, wild-type ABCG2-transfected cells were not more than 2-fold resistant to any of the compounds, suggesting that the PKIs are not significantly transported by ABCG2. BIMs I, II, III, IV, and V, K252c, and arcyriaflavin A were also able to inhibit [(125)I]iodoarylazidoprazosin labeling of ABCG2 by 65% to 80% at 20 micromol/L, compared with a 50% to 70% reduction by 20 micromol/L fumitremorgin C. K252c and arcyriaflavin A were the most potent compounds, with IC(50) values for inhibition of [(125)I]iodoarylazidoprazosin labeling of 0.37 and 0.23 micromol/L, respectively. K252c and arcyriaflavin A did not have any effect on the ATPase activity of ABCG2. Four minimally toxic compounds--BIM IV, BIM V, arcyriaflavin A, and K252c-reduced the relative resistance of ABCG2-transfected cells to SN-38 in cytotoxicity assays. We find that indolocarbazole and BIM PKIs directly interact with the ABCG2 protein and may thus increase oral bioavailability of ABCG2 substrates. JF - Molecular cancer therapeutics AU - Robey, Robert W AU - Shukla, Suneet AU - Steadman, Kenneth AU - Obrzut, Tomasz AU - Finley, Elizabeth M AU - Ambudkar, Suresh V AU - Bates, Susan E AD - Medical Oncology Branch and Laboratory of Cell Biology, Center for Cancer Research, NIH, Bethesda, Maryland, USA. robeyr@mail.nih.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 1877 EP - 1885 VL - 6 IS - 6 SN - 1535-7163, 1535-7163 KW - ABCG2 protein, human KW - 0 KW - ATP Binding Cassette Transporter, Sub-Family G, Member 2 KW - Carbazoles KW - Indoles KW - Maleimides KW - Neoplasm Proteins KW - Protein Kinase Inhibitors KW - bisindolylmaleimide KW - MBK3OO5K8T KW - Index Medicus KW - Molecular Structure KW - Humans KW - Biological Transport KW - Cell Line KW - Protein Kinase Inhibitors -- pharmacology KW - Neoplasm Proteins -- antagonists & inhibitors KW - Carbazoles -- chemistry KW - ATP-Binding Cassette Transporters -- metabolism KW - Maleimides -- chemistry KW - Protein Kinase Inhibitors -- chemistry KW - ATP-Binding Cassette Transporters -- antagonists & inhibitors KW - Neoplasm Proteins -- metabolism KW - Indoles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70608799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Inhibition+of+ABCG2-mediated+transport+by+protein+kinase+inhibitors+with+a+bisindolylmaleimide+or+indolocarbazole+structure.&rft.au=Robey%2C+Robert+W%3BShukla%2C+Suneet%3BSteadman%2C+Kenneth%3BObrzut%2C+Tomasz%3BFinley%2C+Elizabeth+M%3BAmbudkar%2C+Suresh+V%3BBates%2C+Susan+E&rft.aulast=Robey&rft.aufirst=Robert&rft.date=2007-06-01&rft.volume=6&rft.issue=6&rft.spage=1877&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-15 N1 - Date created - 2007-06-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tobacco craving predicts lapse to smoking among adolescent smokers in cessation treatment. AN - 70604972; 17558821 AB - Previous research indicates that tobacco craving predicts relapse to smoking among adult smokers attempting to quit. We hypothesized a similar relationship between craving and lapse (any smoking following a period of abstinence) among adolescent smokers during the treatment phase of a clinical trial. A visit was considered a lapse visit if the participant reported smoking or had a carbon monoxide level of 7 ppm or greater subsequent to an abstinent visit. A total of 34 participants (mean age = 14.9 years [SD = 1.3]; mean cigarettes/day = 18.0 [SD = 7.6]; mean Fagerström Test for Nicotine Dependence score = 6.8 [SD = 1.34]; 65% female), were included in the present analysis of 167 treatment visits. Logistic regression analyses showed a positive relationship between degree of craving, measured by the Questionnaire on Smoking Urges, and lapse during smoking cessation treatment (p = .013). Additionally, linear regression analyses demonstrated a strong positive association between cigarettes smoked per day and craving scores (p<.001). Taken together with other data, these findings suggest that degree of craving might influence tobacco abstinence for adolescent smokers. Thus monitoring and addressing craving appears useful to increase the success of adolescent smoking cessation. JF - Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco AU - Bagot, Kara S AU - Heishman, Stephen J AU - Moolchan, Eric T AD - National Institute on Drug Abuse, Intramural Research Program, Baltimore, MD 21224, USA. Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 647 EP - 652 VL - 9 IS - 6 SN - 1462-2203, 1462-2203 KW - Index Medicus KW - Severity of Illness Index KW - Evidence-Based Medicine KW - Health Promotion -- methods KW - Double-Blind Method KW - Humans KW - Linear Models KW - Treatment Outcome KW - Maryland -- epidemiology KW - Adolescent KW - Research Design KW - Recurrence KW - Male KW - Female KW - Risk Reduction Behavior KW - Tobacco Use Disorder -- epidemiology KW - Smoking Cessation -- methods KW - Tobacco Use Disorder -- prevention & control KW - Smoking -- prevention & control KW - Smoking -- epidemiology KW - Smoking Cessation -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70604972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=Tobacco+craving+predicts+lapse+to+smoking+among+adolescent+smokers+in+cessation+treatment.&rft.au=Bagot%2C+Kara+S%3BHeishman%2C+Stephen+J%3BMoolchan%2C+Eric+T&rft.aulast=Bagot&rft.aufirst=Kara&rft.date=2007-06-01&rft.volume=9&rft.issue=6&rft.spage=647&rft.isbn=&rft.btitle=&rft.title=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=14622203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-13 N1 - Date created - 2007-06-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - New insights into the pathogenesis and treatment of anthrax toxin-induced shock. AN - 70603158; 17555370 AB - Inhalational Bacillus anthracis infection is a leading bioterrorist health threat in the US today. Lethal (LeTx) and edema toxin production are key to the virulent effects of this lethal bacteria. Recent insights into the structure and function of these toxins have increased the understanding of both the pathogenesis and treatment of anthrax. These are binary type toxins comprised of protective antigen necessary for their cellular uptake and either lethal or edema factors, the toxigenic moieties. Primary cellular receptors for protective antigen have been identified and the processing of the completed toxins clarified. Consistent with the ability of lethal factor to cleave mitogen activated protein kinase kinases, the evidence indicates that an excessive inflammatory response does not contribute to shock with LeTx. Rather, the immunosuppressive effects of LeTx could promote infection; however, direct endothelial dysfunction may have an important role in shock due to LeTx. Recent studies show that edema factor, a potent adenyl cyclase, may have a major role in shock during anthrax and that it may also be immunosuppresive. Therapies under development which target several steps in the cellular uptake and function of these two toxins have been effective in both in vitro and in vivo systems. Understanding how best to apply these agents in combination with conventional treatments should be a goal of future research. JF - Expert opinion on biological therapy AU - Li, Yan AU - Sherer, Kevin AU - Cui, Xizhong AU - Eichacker, Peter Q AD - National Institutes of Health, Critical Care Medicine Department, Clinical Center, Bethesda, MD 20892, USA. Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 843 EP - 854 VL - 7 IS - 6 KW - Anthrax Vaccines KW - 0 KW - Antibodies, Monoclonal KW - Antigens, Bacterial KW - Bacterial Toxins KW - Receptors, Peptide KW - anthrax toxin KW - anthrax toxin receptors KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Index Medicus KW - Virulence KW - Animals KW - Receptors, Peptide -- metabolism KW - Humans KW - Endothelium, Vascular -- physiopathology KW - Endothelium, Vascular -- microbiology KW - Antigens, Bacterial -- metabolism KW - Shock, Septic -- drug therapy KW - Adenylyl Cyclases -- metabolism KW - Anthrax -- complications KW - Antigens, Bacterial -- immunology KW - Bacterial Toxins -- immunology KW - Anthrax -- metabolism KW - Bacillus anthracis -- immunology KW - Shock, Septic -- metabolism KW - Antibodies, Monoclonal -- therapeutic use KW - Bacterial Toxins -- metabolism KW - Shock, Septic -- microbiology KW - Anthrax Vaccines -- therapeutic use KW - Adenylyl Cyclases -- immunology KW - Bacillus anthracis -- pathogenicity KW - Bacillus anthracis -- metabolism KW - Shock, Septic -- physiopathology KW - Anthrax -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70603158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+biological+therapy&rft.atitle=New+insights+into+the+pathogenesis+and+treatment+of+anthrax+toxin-induced+shock.&rft.au=Li%2C+Yan%3BSherer%2C+Kevin%3BCui%2C+Xizhong%3BEichacker%2C+Peter+Q&rft.aulast=Li&rft.aufirst=Yan&rft.date=2007-06-01&rft.volume=7&rft.issue=6&rft.spage=843&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+biological+therapy&rft.issn=1744-7682&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-27 N1 - Date created - 2007-06-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of Ca(2+) channels in short-term synaptic plasticity. AN - 70602902; 17466513 AB - Repetitive nerve activity induces various forms of short-term synaptic plasticity that have important computational roles in neuronal networks. Several forms of short-term plasticity are caused largely by changes in transmitter release, but the mechanisms that underlie these changes in the release process have been difficult to address. Recent studies of a giant synapse - the calyx of Held - have shed new light on this issue. Recordings of Ca(2+) currents or Ca(2+) concentrations at nerve terminals reveal that regulation of presynaptic Ca(2+) channels has a significant role in three important forms of short-term plasticity: short-term depression, facilitation and post-tetanic potentiation. JF - Current opinion in neurobiology AU - Xu, Jianhua AU - He, Liming AU - Wu, Ling-Gang AD - National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA. Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 352 EP - 359 VL - 17 IS - 3 SN - 0959-4388, 0959-4388 KW - Calcium Channels KW - 0 KW - Neurotransmitter Agents KW - Index Medicus KW - Animals KW - Neurotransmitter Agents -- metabolism KW - Dose-Response Relationship, Radiation KW - Electric Stimulation KW - Time Factors KW - Synapses -- physiology KW - Calcium Channels -- physiology KW - Neuronal Plasticity -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70602902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+neurobiology&rft.atitle=Role+of+Ca%282%2B%29+channels+in+short-term+synaptic+plasticity.&rft.au=Xu%2C+Jianhua%3BHe%2C+Liming%3BWu%2C+Ling-Gang&rft.aulast=Xu&rft.aufirst=Jianhua&rft.date=2007-06-01&rft.volume=17&rft.issue=3&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+neurobiology&rft.issn=09594388&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-02 N1 - Date created - 2007-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cigarette smoking patterns among young adults aged 18-24 years in the United States. AN - 70594521; 17558826 AB - Most tobacco control programs focus on prevention for children or cessation for adults. Little is known about cigarette smoking among young adults. This study examined sociodemographic variables associated with current, daily, heavy, and light smoking among young adults in the United States. Data from the 1998-1999 Tobacco Use Supplement to the Current Population Survey (TUS-CPS) were used to examine cigarette smoking patterns and correlates of smoking among 15,371 young adults aged 18-24 years. We found that 26% of young adults were current smokers, 20% were daily smokers, and 8% were former smokers. Current smoking rates were higher among American Indians/Alaska Natives (33%) and Whites (31%) than among other racial/ethnic groups. Compared with white-collar workers, blue-collar and service workers were more likely to report current and daily smoking. Blue-collar workers also were more likely to report heavy smoking (OR = 1.97). The unemployed (those in the labor force but not currently working) and those reporting an annual household income of less than US$20,000 were more likely to report current, daily, and heavy smoking, compared with those not in the labor force and those reporting an annual household income of $20,000 or more, respectively. Young adults not currently enrolled in school were more than twice as likely to report current (OR = 2.36) and daily (OR = 2.90) smoking, compared with those currently enrolled in school. Differential cigarette smoking patterns by race/ethnicity, occupation, employment status, household income, and school enrollment status should be considered when developing interventions to reduce smoking among young adults. JF - Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco AU - Lawrence, Deirdre AU - Fagan, Pebbles AU - Backinger, Cathy L AU - Gibson, James T AU - Hartman, Anne AD - Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. dl177n@nih.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 687 EP - 697 VL - 9 IS - 6 SN - 1462-2203, 1462-2203 KW - Index Medicus KW - Odds Ratio KW - Humans KW - Health Status KW - Ethnic Groups -- statistics & numerical data KW - Multivariate Analysis KW - Population Surveillance KW - Socioeconomic Factors KW - Adult KW - Confidence Intervals KW - United States -- epidemiology KW - Female KW - Male KW - Prevalence KW - Tobacco Use Disorder -- epidemiology KW - Tobacco Use Disorder -- psychology KW - Health Behavior KW - Smoking -- psychology KW - Smoking -- epidemiology KW - Smoking Cessation -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70594521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=Cigarette+smoking+patterns+among+young+adults+aged+18-24+years+in+the+United+States.&rft.au=Lawrence%2C+Deirdre%3BFagan%2C+Pebbles%3BBackinger%2C+Cathy+L%3BGibson%2C+James+T%3BHartman%2C+Anne&rft.aulast=Lawrence&rft.aufirst=Deirdre&rft.date=2007-06-01&rft.volume=9&rft.issue=6&rft.spage=687&rft.isbn=&rft.btitle=&rft.title=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=14622203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-13 N1 - Date created - 2007-06-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Persistent synaptic activity produces long-lasting enhancement of endocannabinoid modulation and alters long-term synaptic plasticity. AN - 70593961; 17392410 AB - Learning and memory are thought to involve activity-dependent changes in synaptic efficacy such as long-term potentiation (LTP) and long-term depression (LTD). Recent studies have indicated that endocannabinoid-dependent modulation of inhibitory transmission facilitates induction of hippocampal LTP and that endocannabinoids play a key role in certain forms of LTD. Here, we show that repetitive low-frequency synaptic stimulation (LFS) produces persistent up-regulation of endocannabinoid signaling at hippocampal CA1 GABAergic synapses. This LFS also produces LTD of inhibitory synapses and facilitates LTP at excitatory, glutamatergic synapses. These endocannabinoid-mediated plastic changes could contribute to information storage within the brain. JF - Journal of neurophysiology AU - Zhu, Ping Jun AU - Lovinger, David M AD - Lab. for Integrative Neuroscience, NIH/NIAAA, 5625 Fishers Lane, Rm. TS-28, Bethesda, MD 20892-9411, USA. Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 4386 EP - 4389 VL - 97 IS - 6 SN - 0022-3077, 0022-3077 KW - Cannabinoid Receptor Modulators KW - 0 KW - Endocannabinoids KW - Excitatory Amino Acid Antagonists KW - Piperidines KW - Pyrazoles KW - Pyridines KW - 6-methyl-2-(phenylethynyl)pyridine KW - 7VC0YVI27Y KW - rimonabant KW - RML78EN3XE KW - Index Medicus KW - Patch-Clamp Techniques -- methods KW - Animals KW - Electric Stimulation -- methods KW - Neural Inhibition KW - Dose-Response Relationship, Radiation KW - Inhibitory Postsynaptic Potentials -- drug effects KW - Inhibitory Postsynaptic Potentials -- physiology KW - Inhibitory Postsynaptic Potentials -- radiation effects KW - Excitatory Amino Acid Antagonists -- pharmacology KW - Rats KW - Piperidines -- pharmacology KW - Pyrazoles -- pharmacology KW - Rats, Sprague-Dawley KW - Excitatory Postsynaptic Potentials -- drug effects KW - Excitatory Postsynaptic Potentials -- radiation effects KW - Hippocampus -- cytology KW - In Vitro Techniques KW - Time Factors KW - Pyridines -- pharmacology KW - Excitatory Postsynaptic Potentials -- physiology KW - Synapses -- physiology KW - Cannabinoid Receptor Modulators -- physiology KW - Neurons -- physiology KW - Neuronal Plasticity -- physiology KW - Neuronal Plasticity -- drug effects KW - Cannabinoid Receptor Modulators -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70593961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurophysiology&rft.atitle=Persistent+synaptic+activity+produces+long-lasting+enhancement+of+endocannabinoid+modulation+and+alters+long-term+synaptic+plasticity.&rft.au=Zhu%2C+Ping+Jun%3BLovinger%2C+David+M&rft.aulast=Zhu&rft.aufirst=Ping&rft.date=2007-06-01&rft.volume=97&rft.issue=6&rft.spage=4386&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurophysiology&rft.issn=00223077&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-15 N1 - Date created - 2007-06-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Letrozole treatment of precocious puberty in girls with the McCune-Albright syndrome: a pilot study. AN - 70591486; 17405850 AB - Girls with McCune-Albright syndrome (MAS) and related disorders have gonadotropin-independent precocious puberty due to estrogen secretion from ovarian cysts. Their puberty does not respond to GnRH agonist therapy, and short-acting aromatase inhibitors have had limited effectiveness. Our objective was to assess the effectiveness of the potent, third-generation aromatase inhibitor letrozole in decreasing pubertal progression in girls with MAS and to assess the response of indices of bone turnover associated with the patients' polyostotic fibrous dysplasia. Subjects were evaluated at baseline and every 6 months for 12-36 months while on treatment with letrozole 1.5-2.0 mg/m(2).d. This was an open-label therapeutic trial at a single clinical center. Patients included nine girls aged 3-8 yr with MAS and/or gonadotropin-independent puberty. Measures included rates of linear growth, bone age advance, mean ovarian volume, estradiol, episodes of vaginal bleeding, and levels of the indices of bone metabolism: serum osteocalcin, alkaline phosphatase, urinary hydroxyproline, pyridinoline, deoxypyridinoline, and N-telopeptides. Girls had decreased rates of growth (P < or = 0.01) and bone age advance (P < or = 0.004) and cessation or slowing in their rates of bleeding over 12-36 months of therapy. Mean ovarian volume, estradiol, and indices of bone metabolism fell after 6 months (P < or = 0.05) but tended to rise by 24-36 months. Uterine volumes did not change. One girl had a ruptured ovarian cyst after 2 yr of treatment. This preliminary study suggests that letrozole may be effective therapy in some girls with MAS and/or gonadotropin-independent precocious puberty. Possible adverse effects include ovarian enlargement and cyst formation. JF - The Journal of clinical endocrinology and metabolism AU - Feuillan, Penelope AU - Calis, Karim AU - Hill, Suvimol AU - Shawker, Thomas AU - Robey, Pamela Gehron AU - Collins, Michael T AD - National Institutes of Health, Bethesda, MD 20892, USA. feuillap@mail.nih.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 2100 EP - 2106 VL - 92 IS - 6 SN - 0021-972X, 0021-972X KW - Antineoplastic Agents KW - 0 KW - Biomarkers KW - Nitriles KW - Triazoles KW - letrozole KW - 7LKK855W8I KW - Abridged Index Medicus KW - Index Medicus KW - Puberty -- drug effects KW - Humans KW - Biomarkers -- urine KW - Pilot Projects KW - Child KW - Bone and Bones -- metabolism KW - Child, Preschool KW - Ovarian Cysts -- drug therapy KW - Menstruation -- drug effects KW - Ovarian Cysts -- etiology KW - Biomarkers -- blood KW - Female KW - Growth -- drug effects KW - Male KW - Antineoplastic Agents -- administration & dosage KW - Fibrous Dysplasia, Polyostotic -- complications KW - Nitriles -- administration & dosage KW - Triazoles -- blood KW - Antineoplastic Agents -- blood KW - Puberty, Precocious -- drug therapy KW - Triazoles -- adverse effects KW - Puberty, Precocious -- etiology KW - Antineoplastic Agents -- adverse effects KW - Nitriles -- blood KW - Puberty, Precocious -- metabolism KW - Fibrous Dysplasia, Polyostotic -- metabolism KW - Nitriles -- adverse effects KW - Triazoles -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70591486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+endocrinology+and+metabolism&rft.atitle=Letrozole+treatment+of+precocious+puberty+in+girls+with+the+McCune-Albright+syndrome%3A+a+pilot+study.&rft.au=Feuillan%2C+Penelope%3BCalis%2C+Karim%3BHill%2C+Suvimol%3BShawker%2C+Thomas%3BRobey%2C+Pamela+Gehron%3BCollins%2C+Michael+T&rft.aulast=Feuillan&rft.aufirst=Penelope&rft.date=2007-06-01&rft.volume=92&rft.issue=6&rft.spage=2100&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+endocrinology+and+metabolism&rft.issn=0021972X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-18 N1 - Date created - 2007-06-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ethanol reverses the direction of long-term synaptic plasticity in the dorsomedial striatum. AN - 70589936; 17552991 AB - The striatum is a critical structure for the control of voluntary behaviour, and striatal synaptic plasticity has been implicated in instrumental learning. As ethanol consumption can cause impairments in cognition, learning, and action selection, it is important to understand the effects of this drug on striatal function. In this study we examined the effects of ethanol on long-term synaptic plasticity in the dorsomedial striatum (DMS), a striatal subregion that plays a central role in the acquisition and selection of goal-directed actions. Ethanol was found to impair N-methyl-d-aspartic acid receptor (NMDAR)-dependent long-term potentiation (LTP) dose-dependently in the DMS, and to promote long-term depression (LTD) at the highest concentration (50 mm) used. These results suggest that ethanol, at a concentration usually associated with mild intoxication, could significantly change experience-dependent modification of corticostriatal circuits underlying the learning of goal-directed instrumental actions. JF - The European journal of neuroscience AU - Yin, Henry H AU - Park, Brian S AU - Adermark, Louise AU - Lovinger, David M AD - Section on Synaptic Pharmacology, Laboratory for Integrative Neuroscience, NIAAA/NIH, 5625 Fishers Lane, TS-13, Bethesda, Maryland 20892, USA. Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 3226 EP - 3232 VL - 25 IS - 11 SN - 0953-816X, 0953-816X KW - Central Nervous System Depressants KW - 0 KW - Dopamine Antagonists KW - Piperidines KW - Pyrazoles KW - AM 251 KW - 3I4FA44MAI KW - Ethanol KW - 3K9958V90M KW - Sulpiride KW - 7MNE9M8287 KW - Index Medicus KW - Patch-Clamp Techniques -- methods KW - Animals KW - Sulpiride -- pharmacology KW - Evoked Potentials -- radiation effects KW - Dose-Response Relationship, Drug KW - Dopamine Antagonists -- pharmacology KW - Evoked Potentials -- physiology KW - Dose-Response Relationship, Radiation KW - Electric Stimulation KW - Rats KW - Piperidines -- pharmacology KW - Pyrazoles -- pharmacology KW - Animals, Newborn KW - Evoked Potentials -- drug effects KW - Rats, Sprague-Dawley KW - In Vitro Techniques KW - Time Factors KW - Corpus Striatum -- cytology KW - Central Nervous System Depressants -- pharmacology KW - Ethanol -- pharmacology KW - Synaptic Transmission -- drug effects KW - Neurons -- drug effects KW - Neurons -- physiology KW - Neuronal Plasticity -- drug effects KW - Synaptic Transmission -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70589936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+European+journal+of+neuroscience&rft.atitle=Ethanol+reverses+the+direction+of+long-term+synaptic+plasticity+in+the+dorsomedial+striatum.&rft.au=Yin%2C+Henry+H%3BPark%2C+Brian+S%3BAdermark%2C+Louise%3BLovinger%2C+David+M&rft.aulast=Yin&rft.aufirst=Henry&rft.date=2007-06-01&rft.volume=25&rft.issue=11&rft.spage=3226&rft.isbn=&rft.btitle=&rft.title=The+European+journal+of+neuroscience&rft.issn=0953816X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-15 N1 - Date created - 2007-06-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Vps27/Hse1 complex is a GAT domain-based scaffold for ubiquitin-dependent sorting. AN - 70575050; 17543868 AB - The yeast Vps27/Hse1 complex and the homologous mammalian Hrs/STAM complex deliver ubiquitinated transmembrane proteins to the ESCRT endosomal-sorting pathway. The Vps27/Hse1 complex directly binds to ubiquitinated transmembrane proteins and recruits both ubiquitin ligases and deubiquitinating enzymes. We have solved the crystal structure of the core responsible for the assembly of the Vps27/Hse1 complex at 3.0 A resolution. The structure consists of two intertwined GAT domains, each consisting of two helices from one subunit and one from the other. The two GAT domains are connected by an antiparallel coiled coil, forming a 90 A-long barbell-like structure. This structure places the domains of Vps27 and Hse1 that recruit ubiquitinated cargo and deubiquitinating enzymes close to each other. Coarse-grained Monte Carlo simulations of the Vps27/Hse1 complex on a membrane show how the complex binds cooperatively to lipids and ubiquitinated membrane proteins and acts as a scaffold for ubiquitination reactions. JF - Developmental cell AU - Prag, Gali AU - Watson, Hadiya AU - Kim, Young C AU - Beach, Bridgette M AU - Ghirlando, Rodolfo AU - Hummer, Gerhard AU - Bonifacino, Juan S AU - Hurley, James H AD - Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 973 EP - 986 VL - 12 IS - 6 SN - 1534-5807, 1534-5807 KW - Endosomal Sorting Complexes Required for Transport KW - 0 KW - Hse1 protein, S cerevisiae KW - Receptors, Cytoplasmic and Nuclear KW - Saccharomyces cerevisiae Proteins KW - Ubiquitin KW - VPS27 protein, S cerevisiae KW - Vesicular Transport Proteins KW - Index Medicus KW - Models, Molecular KW - Immunoprecipitation KW - Amino Acid Sequence KW - Protein Binding KW - Mutagenesis, Site-Directed KW - Ubiquitin -- metabolism KW - Chromatography, Gel KW - Molecular Sequence Data KW - Mutation -- genetics KW - Crystallography, X-Ray KW - Sequence Homology, Amino Acid KW - Protein Structure, Tertiary KW - Protein Transport KW - Saccharomyces cerevisiae -- genetics KW - Saccharomyces cerevisiae Proteins -- metabolism KW - Vesicular Transport Proteins -- genetics KW - Saccharomyces cerevisiae Proteins -- genetics KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Receptors, Cytoplasmic and Nuclear -- chemistry KW - Saccharomyces cerevisiae -- chemistry KW - Receptors, Cytoplasmic and Nuclear -- genetics KW - Vesicular Transport Proteins -- metabolism KW - Saccharomyces cerevisiae Proteins -- chemistry KW - Vesicular Transport Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70575050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+cell&rft.atitle=The+Vps27%2FHse1+complex+is+a+GAT+domain-based+scaffold+for+ubiquitin-dependent+sorting.&rft.au=Prag%2C+Gali%3BWatson%2C+Hadiya%3BKim%2C+Young+C%3BBeach%2C+Bridgette+M%3BGhirlando%2C+Rodolfo%3BHummer%2C+Gerhard%3BBonifacino%2C+Juan+S%3BHurley%2C+James+H&rft.aulast=Prag&rft.aufirst=Gali&rft.date=2007-06-01&rft.volume=12&rft.issue=6&rft.spage=973&rft.isbn=&rft.btitle=&rft.title=Developmental+cell&rft.issn=15345807&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-30 N1 - Date created - 2007-06-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Protein Expr Purif. 2001 Feb;21(1):224-34 [11162410] Nat Rev Mol Cell Biol. 2001 Mar;2(3):169-78 [11265246] Nat Rev Mol Cell Biol. 2001 Mar;2(3):195-201 [11265249] J Cell Sci. 2001 Jun;114(Pt 12):2255-63 [11493665] Cell. 2001 Jul 27;106(2):145-55 [11511343] Traffic. 2001 Sep;2(9):612-21 [11555415] J Cell Sci. 2001 Sep;114(Pt 17):3075-81 [11590234] Mol Cell Biol. 2001 Dec;21(23):7981-94 [11689690] Annu Rev Biochem. 2001;70:503-33 [11395416] Cell. 2002 Jan 25;108(2):261-9 [11832215] Nat Cell Biol. 2002 May;4(5):389-93 [11988742] Nat Cell Biol. 2002 May;4(5):394-8 [11988743] Protein Sci. 2002 Jun;11(6):1285-99 [12021428] Nat Cell Biol. 2002 Jul;4(7):534-9 [12055639] J Biol Chem. 2002 Jul 19;277(29):26379-88 [12006563] Nat Rev Mol Cell Biol. 2002 Dec;3(12):893-905 [12461556] Dev Cell. 2003 Mar;4(3):321-32 [12636914] Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4451-6 [12668765] J Mol Biol. 2003 May 2;328(3):721-36 [12706728] Nat Struct Biol. 2003 May;10(5):386-93 [12679809] Biochemistry. 2003 Jun 3;42(21):6392-9 [12767220] Nucleic Acids Res. 2003 Jul 1;31(13):3300-4 [12824312] Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7626-31 [12802020] J Biol Chem. 2003 Aug 1;278(31):28976-84 [12750381] Biochem J. 2006 Nov 1;399(3):361-72 [17034365] Mol Biol Cell. 2007 Jan;18(1):324-35 [17079730] Curr Opin Cell Biol. 2003 Aug;15(4):446-55 [12892785] Anal Biochem. 2003 Sep 1;320(1):104-24 [12895474] J Cell Biol. 2003 Aug 4;162(3):413-23 [12900393] EMBO J. 2003 Sep 15;22(18):4597-606 [12970172] J Cell Biol. 2003 Oct 27;163(2):237-43 [14581452] Trends Biochem Sci. 2003 Nov;28(11):598-603 [14607090] J Biol Chem. 2003 Nov 28;278(48):48162-8 [13129930] J Biol Chem. 2003 Dec 26;278(52):52865-72 [14563850] Nat Rev Mol Cell Biol. 2004 Jan;5(1):23-32 [14708007] J Biol Chem. 2004 Feb 20;279(8):7105-11 [14660606] Nat Cell Biol. 2004 Mar;6(3):244-51 [15039775] Nat Cell Biol. 2004 Mar;6(3):252-9 [15039776] Nat Rev Mol Cell Biol. 2004 Apr;5(4):317-23 [15071556] Traffic. 2004 Mar;5(3):194-210 [15086794] J Biochem. 2004 Mar;135(3):385-96 [15113837] J Biol Chem. 2004 Jun 4;279(23):24435-43 [15047686] J Biol Chem. 2004 Jul 23;279(30):31409-18 [15143060] Annu Rev Cell Dev Biol. 2004;20:395-425 [15473846] Acta Crystallogr A. 1991 Mar 1;47 ( Pt 2):110-9 [2025413] J Cell Biol. 1995 Nov;131(3):603-17 [7593183] Trends Biochem Sci. 1995 Nov;20(11):478-80 [8578593] J Mol Biol. 1996 Mar 1;256(3):623-44 [8604144] Nucleic Acids Res. 1997 Sep 1;25(17):3389-402 [9254694] Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):905-21 [9757107] Cell. 1999 May 28;97(5):657-66 [10367894] Virus Res. 2004 Dec;106(2):87-102 [15567490] Traffic. 2005 Jan;6(1):2-9 [15569240] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765] J Biochem. 2005 Jan;137(1):1-8 [15713877] Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2334-9 [15701688] J Biol Chem. 2005 Mar 11;280(10):9258-64 [15611048] Genes Cells. 2005 Jul;10(7):639-54 [15966896] Biochim Biophys Acta. 2005 Jul 10;1744(3):438-54 [15913810] Nat Rev Mol Cell Biol. 2005 Aug;6(8):610-21 [16064137] FEBS Lett. 2005 Oct 10;579(24):5385-91 [16199040] Curr Biol. 2006 Jan 24;16(2):160-5 [16431367] Nat Struct Mol Biol. 2006 Mar;13(3):272-7 [16462748] Cell. 2006 Mar 24;124(6):1133-6 [16564007] Structure. 2006 Apr;14(4):661-71 [16615908] Annu Rev Biophys Biomol Struct. 2006;35:277-98 [16689637] J Cell Sci. 2006 Jun 15;119(Pt 12):2414-24 [16720641] Trends Cell Biol. 2006 Jun;16(6):317-26 [16716591] Cell. 2000 Feb 18;100(4):447-56 [10693761] Nat Cell Biol. 2000 Aug;2(8):E153-7 [10934491] Acta Crystallogr D Biol Crystallogr. 2000 Aug;56(Pt 8):965-72 [10944333] Nat Med. 2000 Oct;6(10):1073-81 [11017125] J Biol Chem. 2000 Dec 1;275(48):37481-7 [10982817] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Retroviral insertional mutagenesis identifies genes that collaborate with NUP98-HOXD13 during leukemic transformation. AN - 70573550; 17545593 AB - The t(2;11)(q31;p15) chromosomal translocation results in a fusion between the NUP98 and HOXD13 genes and has been observed in patients with myelodysplastic syndrome (MDS) or acute myelogenous leukemia. We previously showed that expression of the NUP98-HOXD13 (NHD13) fusion gene in transgenic mice results in an invariably fatal MDS; approximately one third of mice die due to complications of severe pancytopenia, and about two thirds progress to a fatal acute leukemia. In the present study, we used retroviral insertional mutagenesis to identify genes that might collaborate with NHD13 as the MDS transformed to an acute leukemia. Newborn NHD13 transgenic mice and littermate controls were infected with the MOL4070LTR retrovirus. The onset of leukemia was accelerated, suggesting a synergistic effect between the NHD13 transgene and the genes neighboring retroviral insertion events. We identified numerous common insertion sites located near protein-coding genes and confirmed dysregulation of a subset of these by expression analyses. Among these genes were Meis1, a known collaborator of HOX and NUP98-HOX fusion genes, and Mn1, a transcriptional coactivator involved in human leukemia through fusion with the TEL gene. Other putative collaborators included Gata2, Erg, and Epor. Of note, we identified a common insertion site that was >100 kb from the nearest coding gene, but within 20 kb of the miR29a/miR29b1 microRNA locus. Both of these miRNA were up-regulated, demonstrating that retroviral insertional mutagenesis can target miRNA loci as well as protein-coding loci. Our data provide new insights into NHD13-mediated leukemogenesis as well as retroviral insertional mutagenesis mechanisms. JF - Cancer research AU - Slape, Christopher AU - Hartung, Helge AU - Lin, Ying-Wei AU - Bies, Juraj AU - Wolff, Linda AU - Aplan, Peter D AD - Genetics Branch, Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20889-5105, USA. Y1 - 2007/06/01/ PY - 2007 DA - 2007 Jun 01 SP - 5148 EP - 5155 VL - 67 IS - 11 SN - 0008-5472, 0008-5472 KW - ERG1 Potassium Channel KW - 0 KW - Ether-A-Go-Go Potassium Channels KW - GATA2 Transcription Factor KW - Gata2 protein, mouse KW - Homeodomain Proteins KW - Hoxd13 protein, mouse KW - Kcnh2 protein, mouse KW - MicroRNAs KW - Mn1 protein, mouse KW - Neoplasm Proteins KW - Nuclear Pore Complex Proteins KW - Oncogene Proteins KW - Oncogene Proteins, Fusion KW - Transcription Factors KW - myeloid ecotropic viral integration site 1 protein KW - nuclear pore complex protein 98 KW - Index Medicus KW - Animals KW - Ether-A-Go-Go Potassium Channels -- genetics KW - MicroRNAs -- genetics KW - Neoplasm Proteins -- genetics KW - Oncogene Proteins -- genetics KW - Moloney murine leukemia virus -- genetics KW - Mice KW - Mice, Transgenic KW - NIH 3T3 Cells KW - Mutagenesis, Insertional KW - Cell Transformation, Neoplastic -- genetics KW - GATA2 Transcription Factor -- genetics KW - Cloning, Molecular KW - Homeodomain Proteins -- genetics KW - Oncogene Proteins, Fusion -- genetics KW - Leukemia, Myeloid -- genetics KW - Transcription Factors -- genetics KW - Nuclear Pore Complex Proteins -- genetics KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70573550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Retroviral+insertional+mutagenesis+identifies+genes+that+collaborate+with+NUP98-HOXD13+during+leukemic+transformation.&rft.au=Slape%2C+Christopher%3BHartung%2C+Helge%3BLin%2C+Ying-Wei%3BBies%2C+Juraj%3BWolff%2C+Linda%3BAplan%2C+Peter+D&rft.aulast=Slape&rft.aufirst=Christopher&rft.date=2007-06-01&rft.volume=67&rft.issue=11&rft.spage=5148&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-26 N1 - Date created - 2007-06-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Mol Biol. 1988 Sep 5;203(1):131-9 [3054118] Leukemia. 2005 Apr;19(4):636-43 [15744344] Oncogene. 1995 Apr 20;10(8):1511-9 [7731705] Blood. 1995 Jun 15;85(12):3713-8 [7780155] Mol Cell Biol. 1995 Oct;15(10):5434-43 [7565694] Nat Genet. 1999 Nov;23(3):348-53 [10610183] Biochem Biophys Res Commun. 2000 Jun 24;273(1):239-45 [10873593] Mol Cell Biol. 2001 Jan;21(1):224-34 [11113197] EMBO J. 2001 Feb 1;20(3):350-61 [11157742] Methods. 2001 Dec;25(4):402-8 [11846609] Blood. 2002 Jul 1;100(1):238-45 [12070033] Blood. 2002 Jul 1;100(1):246-58 [12070034] Blood. 2005 Jul 1;106(1):287-95 [15755899] Cancer Res. 2005 Jul 15;65(14):6029-33 [16024602] Cancer Res. 2005 Aug 15;65(16):7065-70 [16103053] Oncogene. 2005 Nov 21;24(52):7656-72 [16299527] Blood. 2005 Dec 15;106(13):4269-77 [16105979] J Clin Oncol. 2005 Dec 20;23(36):9234-42 [16275934] Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19075-80 [16365291] Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2257-61 [16461460] Blood. 2006 Mar 15;107(6):2540-3 [16282337] Cancer Res. 2006 Jul 1;66(13):6628-37 [16818636] Biochem Biophys Res Commun. 2006 Oct 13;349(1):59-68 [16934749] Blood. 2006 Dec 1;108(12):3898-905 [16912223] Blood. 2007 Feb 15;109(4):1460-71 [17038527] Cancer Cell. 2002 Jun;1(5):417-20 [12124171] Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11293-8 [12151601] Annu Rev Genomics Hum Genet. 2002;3:179-98 [12194988] Nat Genet. 2002 Sep;32(1):160-5 [12185367] J Exp Med. 2003 Feb 3;197(3):281-96 [12566412] Oncogene. 2003 Feb 6;22(5):699-709 [12569362] J Virol. 2003 Apr;77(8):4965-71 [12663802] Blood. 2003 Jun 1;101(11):4529-38 [12543865] Science. 2003 Jun 13;300(5626):1749-51 [12805549] Cell. 2003 Oct 17;115(2):135-8 [14567911] Nucleic Acids Res. 2004 Jan 1;32(Database issue):D523-7 [14681473] Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4924-9 [15044690] Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11334-7 [15273287] PLoS Biol. 2004 Aug;2(8):E234 [15314653] Trends Mol Med. 2004 Oct;10(10):500-7 [15464450] Virology. 1970 Dec;42(4):1136-9 [4099080] Nat Genet. 1996 Feb;12(2):154-8 [8563753] EMBO J. 1998 Jul 1;17(13):3714-25 [9649441] Cancer Res. 1998 Oct 1;58(19):4269-73 [9766650] Science. 1999 Oct 15;286(5439):531-7 [10521349] Blood. 2005 Jan 15;105(2):784-93 [15454493] Nature. 1990 Mar 29;344(6265):444-7 [2320112] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Processed meat intake, CYP2A6 activity and risk of colorectal adenoma. AN - 70572418; 17277235 AB - Red and processed meat intake is associated with increased risks of both colorectal adenoma and cancer. Processed meats contain nitrate and nitrite, precursors of N-nitroso compounds (NOCs); furthermore, meats cooked at high temperatures contain heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs). Specific NOC, HCA and PAH are mutagens and animal carcinogens. We conducted a case-control study of 146 cases of colorectal adenoma, diagnosed at sigmoidoscopy or colonoscopy, and 228 polyp-free controls. We calculated odds ratios (ORs) [and 95% confidence intervals (CIs)] and found a 2-fold increased risk in the highest, compared with the lowest, quartile of processed meat intake (95% CI = 1.0-4.0). We estimated nitrate and nitrite intake from meat using published data from the literature as well as from actual measurements of meats analyzed recently. We evaluated the interaction of processed meat and nitrate plus nitrite intake with CYP2A6 activity, an enzyme able to metabolize some NOC to their carcinogenic form. Results for both methods of estimating nitrate and nitrite intake were similar; compared with the lowest, the highest quartile based on measured values was associated with a 2-fold elevated risk (95% CI = 1.0-3.9). Adjustment for the HCA 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) attenuated the association (OR = 1.6, 95% CI = 0.8-3.2), but other HCA and PAH had minimal effect. Higher CYP2A6 activity was not associated with risk and there was no evidence of an interaction of CYP2A6 activity with nitrate and nitrite intake. Our results suggest that nitrite and nitrate intake from processed meat intake increases the risk of colorectal adenoma after accounting for HCA and PAH. JF - Carcinogenesis AU - Ward, Mary H AU - Cross, Amanda J AU - Divan, Hozefa AU - Kulldorff, Martin AU - Nowell-Kadlubar, Susan AU - Kadlubar, Fred F AU - Sinha, Rashmi AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7240, USA. wardm@mail.nih.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 1210 EP - 1216 VL - 28 IS - 6 SN - 0143-3334, 0143-3334 KW - Mixed Function Oxygenases KW - EC 1.- KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP2A6 protein, human KW - Cytochrome P-450 CYP2A6 KW - Index Medicus KW - Risk Factors KW - Humans KW - Case-Control Studies KW - Enzyme Activation -- physiology KW - Middle Aged KW - Male KW - Female KW - Mixed Function Oxygenases -- physiology KW - Adenoma -- enzymology KW - Aryl Hydrocarbon Hydroxylases -- physiology KW - Meat Products KW - Diet KW - Colorectal Neoplasms -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70572418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Processed+meat+intake%2C+CYP2A6+activity+and+risk+of+colorectal+adenoma.&rft.au=Ward%2C+Mary+H%3BCross%2C+Amanda+J%3BDivan%2C+Hozefa%3BKulldorff%2C+Martin%3BNowell-Kadlubar%2C+Susan%3BKadlubar%2C+Fred+F%3BSinha%2C+Rashmi&rft.aulast=Ward&rft.aufirst=Mary&rft.date=2007-06-01&rft.volume=28&rft.issue=6&rft.spage=1210&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-07 N1 - Date created - 2007-06-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion. AN - 70570501; 17234718 AB - The poor prognosis associated with head and neck squamous cell carcinoma (HNSCC) is primarily due to both local invasion and the regional and/or distant metastatic spread. Recent findings have provided evidence that the acquisition of a motile and invasive phenotype by cancer cells involves the dysregulated function of key intracellular molecular mechanisms together with aberrant signaling events initiated by the surrounding microenvironment. These intrinsic and extrinsic biochemical pathways in turn often converge to stimulate the activity of members of the Rho family of Ras-related guanosine triphosphate (GTP)-binding proteins, including RhoA, Rac and Cdc42, which control the organization of the actin cytoskeleton thereby regulating cell adhesion, polarity and motility. In this study, we examined the status of activation of these GTPases in a representative collection of HNSCC cell lines. Surprisingly, we found that most HNSCC cells exhibit remarkably high levels of GTP-bound Rac1. Further analysis revealed that the activation of Rac1 in these HNSCC cells could be due to two independent signaling events, an epidermal growth factor receptor (EGFR)-based autocrine loop that leads to the activation of the Rac1 exchange factor Vav2 and an EGFR/Vav2-independent pathway that arises as a consequence of the oncogenic mutation of the H-ras proto-oncogene. Indeed, we provide evidence that the EGFR/Vav2/Rac1 axis is a crucial pathway for the acquisition of motile and invasive properties of most HNSCC cells. These findings shed light onto the molecular mechanisms involved in HNSCC cell invasion, and may reveal new therapeutic opportunities to halt the metastatic spread of these aggressive malignancies. JF - Carcinogenesis AU - Patel, Vyomesh AU - Rosenfeldt, Hans M AU - Lyons, Ruth AU - Servitja, Joan-Marc AU - Bustelo, Xosé R AU - Siroff, Mary AU - Gutkind, J Silvio AD - Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 1145 EP - 1152 VL - 28 IS - 6 SN - 0143-3334, 0143-3334 KW - Proto-Oncogene Proteins c-vav KW - 0 KW - VAV2 protein, human KW - EGFR protein, human KW - EC 2.7.10.1 KW - Receptor, Epidermal Growth Factor KW - rac1 GTP-Binding Protein KW - EC 3.6.5.2 KW - Index Medicus KW - Neoplasm Invasiveness KW - Epithelial Cells -- enzymology KW - Epithelial Cells -- pathology KW - Humans KW - Cell Movement -- physiology KW - Molecular Sequence Data KW - Enzyme Activation -- physiology KW - Cell Line, Tumor KW - Amino Acid Sequence KW - Cell Line, Transformed KW - rac1 GTP-Binding Protein -- physiology KW - Signal Transduction -- physiology KW - Head and Neck Neoplasms -- metabolism KW - Carcinoma, Squamous Cell -- pathology KW - rac1 GTP-Binding Protein -- metabolism KW - Head and Neck Neoplasms -- pathology KW - Carcinoma, Squamous Cell -- metabolism KW - Receptor, Epidermal Growth Factor -- physiology KW - Proto-Oncogene Proteins c-vav -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70570501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Persistent+activation+of+Rac1+in+squamous+carcinomas+of+the+head+and+neck%3A+evidence+for+an+EGFR%2FVav2+signaling+axis+involved+in+cell+invasion.&rft.au=Patel%2C+Vyomesh%3BRosenfeldt%2C+Hans+M%3BLyons%2C+Ruth%3BServitja%2C+Joan-Marc%3BBustelo%2C+Xos%C3%A9+R%3BSiroff%2C+Mary%3BGutkind%2C+J+Silvio&rft.aulast=Patel&rft.aufirst=Vyomesh&rft.date=2007-06-01&rft.volume=28&rft.issue=6&rft.spage=1145&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-07 N1 - Date created - 2007-06-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Long-term effects of combination treatment with fludarabine and low-dose pulse cyclophosphamide in patients with lupus nephritis. AN - 70569596; 17317716 AB - To determine the safety and efficacy of a short course of fludarabine combined with cyclophoshamide in lupus nephritis. A phase I/II open label pilot study. Thirteen patients with active proliferative lupus nephritis received monthly oral boluses of low-dose cyclophoshamide (0.5 gm/m(2) on day 1) and subcutaneous fludarabine (30 mg/m(2) on days 1-3) for 3-6 cycles. Concomitant prednisone was aggressively tapered from 0.5 mg/kg/day to a low-dose, alternate-day schedule. Patients were followed for at least 24 months after therapy. The primary outcome was the number of patients achieving renal remission defined as stable creatinine, proteinuria <1 gm/day and inactive urine sediment for at least 6 months. The study was terminated early because of bone marrow toxicity. Eleven patients who received at least three cycles were evaluated for efficacy. Ten patients improved markedly with seven patients achieving complete remission and three patients achieving partial remission. There were three serious haematological adverse events during the treatment with one death due to transfusion-associated graft vs host disease. Profound and prolonged CD4 (mean CD4: 98/microl at 7 months and 251/microl at 12 months) and CD20 lymphocytopenia was noted in most patients. Three patients developed Herpes zoster infections. A short course of low-dose fludarabine and cyclophoshamide can induce long-lasting remissions in patients with proliferative lupus nephritis, but severe myelosuppression limits its widespread use. JF - Rheumatology (Oxford, England) AU - Illei, G G AU - Yarboro, C H AU - Kuroiwa, T AU - Schlimgen, R AU - Austin, H A AU - Tisdale, J F AU - Chitkara, P AU - Fleisher, T AU - Klippel, J H AU - Balow, J E AU - Boumpas, D T AD - National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. illeig@mail.nih.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 952 EP - 956 VL - 46 IS - 6 SN - 1462-0324, 1462-0324 KW - Immunosuppressive Agents KW - 0 KW - Cyclophosphamide KW - 8N3DW7272P KW - Vidarabine KW - FA2DM6879K KW - fludarabine KW - P2K93U8740 KW - Abridged Index Medicus KW - Index Medicus KW - Drug Administration Schedule KW - Lymphopenia -- chemically induced KW - Humans KW - Aged KW - Neutropenia -- chemically induced KW - Pilot Projects KW - CD4 Lymphocyte Count KW - Drug Therapy, Combination KW - Proteinuria -- drug therapy KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Female KW - Male KW - Vidarabine -- analogs & derivatives KW - Lupus Nephritis -- drug therapy KW - Cyclophosphamide -- therapeutic use KW - Vidarabine -- therapeutic use KW - Vidarabine -- adverse effects KW - Immunosuppressive Agents -- therapeutic use KW - Immunosuppressive Agents -- adverse effects KW - Cyclophosphamide -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70569596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rheumatology+%28Oxford%2C+England%29&rft.atitle=Long-term+effects+of+combination+treatment+with+fludarabine+and+low-dose+pulse+cyclophosphamide+in+patients+with+lupus+nephritis.&rft.au=Illei%2C+G+G%3BYarboro%2C+C+H%3BKuroiwa%2C+T%3BSchlimgen%2C+R%3BAustin%2C+H+A%3BTisdale%2C+J+F%3BChitkara%2C+P%3BFleisher%2C+T%3BKlippel%2C+J+H%3BBalow%2C+J+E%3BBoumpas%2C+D+T&rft.aulast=Illei&rft.aufirst=G&rft.date=2007-06-01&rft.volume=46&rft.issue=6&rft.spage=952&rft.isbn=&rft.btitle=&rft.title=Rheumatology+%28Oxford%2C+England%29&rft.issn=14620324&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-07 N1 - Date created - 2007-05-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Trastuzumab, paclitaxel, carboplatin, and gemcitabine in advanced human epidermal growth factor receptor-2/neu-positive urothelial carcinoma: results of a multicenter phase II National Cancer Institute trial. AN - 70568583; 17538166 AB - We investigated the safety and efficacy (response rates, time to disease progression, survival) of trastuzumab, carboplatin, gemcitabine, and paclitaxel in advanced urothelial carcinoma patients and prospectively evaluated human epidermal growth factor receptor-2 (Her-2/neu) overexpression rates. Advanced urothelial carcinoma patients were screened for Her-2/neu overexpression. Eligibility for therapy required human epidermal growth factor receptor-2 (Her-2/neu) overexpression by immunohistochemistry (IHC), gene amplification and/or elevated serum Her-2/neu, no prior chemotherapy for metastasis, and adequate organ function including a normal cardiac function. Treatment consisted of trastuzumab (T) 4 mg/kg loading dose followed by 2 mg/kg on days 1, 8, and 15; paclitaxel (P) 200 mg/m2 on day 1; carboplatin (C; area under the curve, 5) on day 1; and gemcitabine (G) 800 mg/m2 on days 1 and 8. The primary end point was cardiac toxicity. Fifty-seven (52.3%) of 109 registered patients were Her-2/neu positive, and 48.6% were positive by IHC. Her-2/neu-positive patients had more metastatic sites and visceral metastasis than did Her-2/neu negative patients. Forty-four of 57 Her-2/neu-positive patients were treated with TPCG. The median number of cycles was six (range, 1 to 12 cycles). The most common grade 3/4 toxicity was myelosuppression. Grade 3 sensory neuropathy occurred in 14% of patients, and 22.7% experienced grade 1 to 3 cardiac toxicity (grade 3, n = 2: one left ventricular dysfunction, one tachycardia). There were three [corrected] therapy-related deaths. Thirty-one (70%) of 44 patients responded (five complete and 26 partial), and 25 (57%) of 44 were confirmed responses. Median time to progression and survival were 9.3 and 14.1 months, respectively. We prospectively characterized Her-2/neu status in advanced urothelial carcinoma patients. TPCG is feasible; cardiac toxicity rates were higher than projected, but the majority were grade two or lower. Determining the true contribution of trastuzumab requires a randomized trial. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Hussain, Maha H A AU - MacVicar, Gary R AU - Petrylak, Daniel P AU - Dunn, Rodney L AU - Vaishampayan, Ulka AU - Lara, Primo N AU - Chatta, Gurkamal S AU - Nanus, David M AU - Glode, L Michael AU - Trump, Donald L AU - Chen, Helen AU - Smith, David C AU - National Cancer Institute AD - University of Michigan, Ann Arbor, USA. mahahuss@umich.edu ; National Cancer Institute Y1 - 2007/06/01/ PY - 2007 DA - 2007 Jun 01 SP - 2218 EP - 2224 VL - 25 IS - 16 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Deoxycytidine KW - 0W860991D6 KW - gemcitabine KW - B76N6SBZ8R KW - Carboplatin KW - BG3F62OND5 KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Receptor, ErbB-2 KW - Trastuzumab KW - P188ANX8CK KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Paclitaxel -- administration & dosage KW - Deoxycytidine -- analogs & derivatives KW - Humans KW - Aged KW - Carboplatin -- administration & dosage KW - Antibodies, Monoclonal -- administration & dosage KW - Prospective Studies KW - Aged, 80 and over KW - Adult KW - Deoxycytidine -- administration & dosage KW - Middle Aged KW - Antibodies, Monoclonal -- adverse effects KW - Immunohistochemistry KW - Male KW - Female KW - Receptor, ErbB-2 -- analysis KW - Urinary Bladder Neoplasms -- chemistry KW - Urinary Bladder Neoplasms -- drug therapy KW - Urinary Bladder Neoplasms -- mortality KW - Receptor, Epidermal Growth Factor -- analysis KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70568583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Trastuzumab%2C+paclitaxel%2C+carboplatin%2C+and+gemcitabine+in+advanced+human+epidermal+growth+factor+receptor-2%2Fneu-positive+urothelial+carcinoma%3A+results+of+a+multicenter+phase+II+National+Cancer+Institute+trial.&rft.au=Hussain%2C+Maha+H+A%3BMacVicar%2C+Gary+R%3BPetrylak%2C+Daniel+P%3BDunn%2C+Rodney+L%3BVaishampayan%2C+Ulka%3BLara%2C+Primo+N%3BChatta%2C+Gurkamal+S%3BNanus%2C+David+M%3BGlode%2C+L+Michael%3BTrump%2C+Donald+L%3BChen%2C+Helen%3BSmith%2C+David+C%3BNational+Cancer+Institute&rft.aulast=Hussain&rft.aufirst=Maha+H&rft.date=2007-06-01&rft.volume=25&rft.issue=16&rft.spage=2218&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-12 N1 - Date created - 2007-05-31 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Clin Oncol. 2012 Feb 10;30(5):473-5 [22184400] J Clin Oncol. 2007 Jun 1;25(16):2162-3 [17538159] Erratum In: J Clin Oncol. 2008 Jul 1;26(19): 3295 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Risk of precancer and follow-up management strategies for women with human papillomavirus-negative atypical squamous cells of undetermined significance. AN - 70566872; 17540804 AB - To investigate the relative performances of follow-up cytology and carcinogenic human papillomavirus (HPV) DNA testing among carcinogenic HPV-negative women with atypical squamous cells of undetermined significance (ASCUS), for detection of cervical precancer. Twelve-month follow-up management strategies to detect cervical intraepithelial neoplasia grade 3 (CIN3) or worse using cytology or HPV testing or both were compared among women with HPV-negative ASCUS in the Atypical Squamous Cells of Undetermined Significance-Low-Grade Squamous Intraepithelial Lesion (ASCUS-LSIL) Triage Study. Overall only 22 of 1,559 (1.4%) HPV-negative ASCUS women developed CIN grade 3 or worse during follow-up compared with 269 of 1,767 (15.2%) HPV-positive ASCUS women (P<.001). Because of the low risk of disease among HPV-negative ASCUS women, only 7 cases of CIN3 were diagnosed between 12 and 24 months of follow-up, limiting power to distinguish meaningful differences in sensitivity among 12-month testing strategies. The specificity of HPV testing (84%) was significantly higher than cytology using an ASCUS threshold (71%) (P<.001). Cotesting with cytology and HPV testing at 12 months resulted in even lower specificity (61%). Because cases were uncommon, the positive predictive value for subsequent CIN3 or worse was low for cytology (2.6%), Hybrid Capture 2 (3.8%), and cotesting with cytology and HPV testing (2.2%). The negative predictive value for all three management strategies was very high (99.70%, 99.82%, and 100.0% for HPV testing, cytology, or cotesting, respectively.) Women with HPV-negative ASCUS have very low absolute risk of subsequently detected CIN3 or worse in the subsequent 2 years, similar to women with a negative cytology in the absence of HPV testing. The results suggest that women with HPV-negative ASCUS should return to routine screening intervals which may be longer than 1 year depending on age and screening history. However, if increased surveillance is chosen, a single HPV test for carcinogenic types at 12 months has significantly higher specificity and lower referrals than cytology. JF - Obstetrics and gynecology AU - Safaeian, Mahboobeh AU - Solomon, Diane AU - Wacholder, Sholom AU - Schiffman, Mark AU - Castle, Philip AD - Division of Cancer Epidemiology and Genetics and Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20852, USA. safaeianm@mail.nih.g Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 1325 EP - 1331 VL - 109 IS - 6 SN - 0029-7844, 0029-7844 KW - DNA Probes, HPV KW - 0 KW - DNA, Viral KW - Abridged Index Medicus KW - Index Medicus KW - Sensitivity and Specificity KW - Age Factors KW - Neoplasm Staging KW - Humans KW - Predictive Value of Tests KW - Mass Screening -- methods KW - Risk Assessment KW - Multivariate Analysis KW - Risk Factors KW - Papillomaviridae -- isolation & purification KW - Adult KW - Vaginal Smears KW - DNA, Viral -- isolation & purification KW - Follow-Up Studies KW - Adolescent KW - Time Factors KW - Statistics, Nonparametric KW - Female KW - Cervical Intraepithelial Neoplasia -- pathology KW - Papillomavirus Infections -- diagnosis KW - Uterine Cervical Neoplasms -- diagnosis KW - Precancerous Conditions -- epidemiology KW - Precancerous Conditions -- pathology KW - Precancerous Conditions -- virology KW - Papillomavirus Infections -- pathology KW - Papillomavirus Infections -- epidemiology KW - Uterine Cervical Neoplasms -- epidemiology KW - Cervical Intraepithelial Neoplasia -- virology KW - Precancerous Conditions -- diagnosis KW - Cervical Intraepithelial Neoplasia -- diagnosis KW - Uterine Cervical Neoplasms -- pathology KW - Uterine Cervical Neoplasms -- virology KW - Cervical Intraepithelial Neoplasia -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70566872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obstetrics+and+gynecology&rft.atitle=Risk+of+precancer+and+follow-up+management+strategies+for+women+with+human+papillomavirus-negative+atypical+squamous+cells+of+undetermined+significance.&rft.au=Safaeian%2C+Mahboobeh%3BSolomon%2C+Diane%3BWacholder%2C+Sholom%3BSchiffman%2C+Mark%3BCastle%2C+Philip&rft.aulast=Safaeian&rft.aufirst=Mahboobeh&rft.date=2007-06-01&rft.volume=109&rft.issue=6&rft.spage=1325&rft.isbn=&rft.btitle=&rft.title=Obstetrics+and+gynecology&rft.issn=00297844&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-09 N1 - Date created - 2007-06-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hepatocyte-restricted constitutive activation of PPAR alpha induces hepatoproliferation but not hepatocarcinogenesis. AN - 70565511; 17331954 AB - Peroxisome proliferator-activated receptor alpha (PPARalpha) is responsible for peroxisome proliferator-induced pleiotropic responses, including the development of hepatocellular carcinoma in rodents. However, it remains to be determined whether activation of PPARalpha only in hepatocytes is sufficient to induce hepatocellular carcinomas. To address this issue, transgenic mice were generated that target constitutively activated PPARalpha specifically to hepatocytes. The transgenic mice exhibited various responses that mimic wild-type mice treated with peroxisome proliferators, including significantly decreased serum fatty acids and marked induction of PPARalpha target genes encoding fatty acid oxidation enzymes, suggesting that the transgene functions in the same manner as peroxisome proliferators to regulate fatty acid metabolism. However, the transgenic mice did not develop hepatocellular carcinomas, even though they exhibited peroxisome proliferation and hepatocyte proliferation, indicating that these events are not sufficient to induce liver cancer. In contrast to the transgenic mice, peroxisome proliferators activate proliferation of hepatic non-parenchymal cells (NPCs). Thus, activation of hepatic NPCs and/or associated molecular events is an important step in peroxisome proliferators-induced hepatocarcinogenesis. JF - Carcinogenesis AU - Yang, Qian AU - Ito, Shinji AU - Gonzalez, Frank J AD - Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 1171 EP - 1177 VL - 28 IS - 6 SN - 0143-3334, 0143-3334 KW - PPAR alpha KW - 0 KW - Peroxisome Proliferators KW - Index Medicus KW - Animals KW - Peroxisome Proliferators -- metabolism KW - Peroxisome Proliferators -- pharmacology KW - Mice KW - Mice, Transgenic KW - Liver Neoplasms -- pathology KW - Liver Neoplasms -- metabolism KW - Liver Neoplasms -- chemically induced KW - PPAR alpha -- physiology KW - PPAR alpha -- metabolism KW - Hepatocytes -- pathology KW - Hepatocytes -- cytology KW - Cell Proliferation KW - PPAR alpha -- genetics KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70565511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Hepatocyte-restricted+constitutive+activation+of+PPAR+alpha+induces+hepatoproliferation+but+not+hepatocarcinogenesis.&rft.au=Yang%2C+Qian%3BIto%2C+Shinji%3BGonzalez%2C+Frank+J&rft.aulast=Yang&rft.aufirst=Qian&rft.date=2007-06-01&rft.volume=28&rft.issue=6&rft.spage=1171&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-07 N1 - Date created - 2007-06-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Carcinogenesis. 2000 Apr;21(4):823-6 [10753222] J Biol Chem. 2000 Sep 1;275(35):27117-22 [10852923] EXS. 2000;89:141-51 [10997287] J Invest Dermatol. 2000 Nov;115(5):788-94 [11069615] Carcinogenesis. 2000 Dec;21(12):2159-65 [11133804] Carcinogenesis. 2001 Mar;22(3):519-23 [11238195] Annu Rev Med. 2002;53:409-35 [11818483] Curr Med Chem. 2003 Feb;10(4):267-80 [12570700] Crit Rev Toxicol. 2003;33(6):655-780 [14727734] Cell Mol Life Sci. 2004 Feb;61(4):393-416 [14999402] Cancer Res. 2004 Jun 1;64(11):3849-54 [15172993] J Biol Chem. 2004 Oct 22;279(43):44740-8 [15292250] Toxicol Pathol. 2004 Jul-Aug;32 Suppl 2:6-11 [15503658] Science. 1975 Nov 21;190(4216):787-9 [1198095] Proc Natl Acad Sci U S A. 1976 Jun;73(6):2043-6 [180535] Nature. 1980 Jan 24;283(5745):397-8 [6766207] Biochem J. 1982 Apr 1;203(1):161-8 [7103935] Toxicol Appl Pharmacol. 1983 Jan;67(1):15-25 [6845354] Cancer Res. 1988 Dec 1;48(23):6739-44 [3180084] Nature. 1990 Oct 18;347(6294):645-50 [2129546] Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5547-51 [1319065] J Biol Chem. 1995 Feb 3;270(5):2367-71 [7836471] Science. 1995 Jun 23;268(5218):1766-9 [7792603] Cancer Res. 1996 Jan 1;56(1):1-4 [8548746] J Biol Chem. 1996 Oct 4;271(40):24698-710 [8798738] Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10933-8 [8855286] Carcinogenesis. 1997 Aug;18(8):1453-6 [9276615] Chem Res Toxicol. 1997 Oct;10(10):1198-204 [9348444] Mutat Res. 2000 Mar 17;448(2):159-77 [10725470] Carcinogenesis. 1997 Nov;18(11):2029-33 [9395198] Regul Toxicol Pharmacol. 1998 Feb;27(1 Pt 1):47-60 [9629596] Carcinogenesis. 1998 Jul;19(7):1217-22 [9683180] Carcinogenesis. 1998 Nov;19(11):1989-94 [9855014] Carcinogenesis. 2005 Jan;26(1):219-27 [15447978] J Invest Dermatol. 2006 Feb;126(2):374-85 [16374467] Endocrinology. 2006 Oct;147(10):4772-80 [16857745] Mutat Res. 2000 Mar 17;448(2):193-200 [10725472] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - IL-15-induced human DC efficiently prime melanoma-specific naive CD8+ T cells to differentiate into CTL. AN - 70560773; 17492620 AB - Monocytes differentiate into dendritic cells (DC) in response to GM-CSF combined with other cytokines including IL-4 and IL-15. Here, we show that IL15-DC are efficient in priming naive CD8+ T cells to differentiate into melanoma antigen-specific cytotoxic T lymphocytes (CTL). While both melanoma peptide-pulsed IL15-DC and IL4-DC expand high-precursor frequency MART-1-specific CD8+ T cells after two stimulations in vitro, IL15-DC require much lower peptide concentration for priming. IL15-DC are more efficient in expanding gp100-specific CD8+ T cells and can expand CD8+ T cells specific for Tyrosinase and MAGE-3. CTL primed by IL15-DC are superior in their function as demonstrated by (i) higher IFN-gamma secretion, (ii) higher expression of Granzyme B and Perforin, and (iii) higher killing of allogeneic melanoma cell lines, most particularly the HLA-A*0201+ Sk-Mel-24 melanoma cells that are resistant to killing by CD8+ T cells primed with IL4-DC. Supernatants of the sonicated cells demonstrate unique expression of IL-1, IL-8 and IL-15. Therefore, membrane-bound IL-15 might contribute to enhanced priming by IL15-DC. Thus, IL-15 induces myeloid DC that are efficient in priming and maturation of melanoma antigen-specific CTL. JF - European journal of immunology AU - Dubsky, Peter AU - Saito, Hiroaki AU - Leogier, Marylene AU - Dantin, Carole AU - Connolly, John E AU - Banchereau, Jacques AU - Palucka, A Karolina AD - Baylor Institute for Immunology Research, Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX 75204, USA. Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 1678 EP - 1690 VL - 37 IS - 6 SN - 0014-2980, 0014-2980 KW - Antigens, CD KW - 0 KW - Antigens, Neoplasm KW - CCR7 protein, human KW - Interleukin-1 KW - Interleukin-15 KW - Interleukin-8 KW - Lipopolysaccharides KW - MAGEA3 protein, human KW - Neoplasm Proteins KW - Receptors, CCR7 KW - Receptors, Chemokine KW - Interleukin-4 KW - 207137-56-2 KW - Interferon-gamma KW - 82115-62-6 KW - Monophenol Monooxygenase KW - EC 1.14.18.1 KW - Antigens, CD45 KW - EC 3.1.3.48 KW - Granzymes KW - EC 3.4.21.- KW - Index Medicus KW - Coculture Techniques KW - Antigens, CD -- analysis KW - Humans KW - Lipopolysaccharides -- pharmacology KW - Cell Proliferation KW - Lymphocytes -- immunology KW - Monocytes -- cytology KW - Interferon-gamma -- metabolism KW - Lymphocytes -- cytology KW - Antigens, Neoplasm -- immunology KW - Interleukin-8 -- metabolism KW - Monophenol Monooxygenase -- immunology KW - Neoplasm Proteins -- immunology KW - Receptors, Chemokine -- metabolism KW - Interleukin-4 -- pharmacology KW - Lymphocytes -- metabolism KW - Cell Line, Tumor KW - K562 Cells KW - Interleukin-4 -- metabolism KW - Interleukin-1 -- metabolism KW - Monocytes -- immunology KW - Monocytes -- metabolism KW - Antigens, CD -- metabolism KW - Cytotoxicity Tests, Immunologic KW - Granzymes -- metabolism KW - Antigens, CD45 -- metabolism KW - Dendritic Cells -- immunology KW - Dendritic Cells -- metabolism KW - CD8-Positive T-Lymphocytes -- metabolism KW - CD8-Positive T-Lymphocytes -- immunology KW - Dendritic Cells -- drug effects KW - Interleukin-15 -- pharmacology KW - Interleukin-15 -- metabolism KW - T-Lymphocytes, Cytotoxic -- immunology KW - Melanoma -- immunology KW - Cell Differentiation -- drug effects KW - Cell Differentiation -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70560773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+immunology&rft.atitle=IL-15-induced+human+DC+efficiently+prime+melanoma-specific+naive+CD8%2B+T+cells+to+differentiate+into+CTL.&rft.au=Dubsky%2C+Peter%3BSaito%2C+Hiroaki%3BLeogier%2C+Marylene%3BDantin%2C+Carole%3BConnolly%2C+John+E%3BBanchereau%2C+Jacques%3BPalucka%2C+A+Karolina&rft.aulast=Dubsky&rft.aufirst=Peter&rft.date=2007-06-01&rft.volume=37&rft.issue=6&rft.spage=1678&rft.isbn=&rft.btitle=&rft.title=European+journal+of+immunology&rft.issn=00142980&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-11 N1 - Date created - 2007-05-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Human T-cell leukemia virus type 1 integration target sites in the human genome: comparison with those of other retroviruses. AN - 70551414; 17409138 AB - Retroviral integration into the host genome is not entirely random, and integration site preferences vary among different retroviruses. Human immunodeficiency virus (HIV) prefers to integrate within active genes, whereas murine leukemia virus (MLV) prefers to integrate near transcription start sites and CpG islands. On the other hand, integration of avian sarcoma-leukosis virus (ASLV) shows little preference either for genes, transcription start sites, or CpG islands. While host cellular factors play important roles in target site selection, the viral integrase is probably the major viral determinant. It is reasonable to hypothesize that retroviruses with similar integrases have similar preferences for target site selection. Although integration profiles are well defined for members of the lentivirus, spumaretrovirus, alpharetrovirus, and gammaretrovirus genera, no members of the deltaretroviruses, for example, human T-cell leukemia virus type 1 (HTLV-1), have been evaluated. We have mapped 541 HTLV-1 integration sites in human HeLa cells and show that HTLV-1, like ASLV, does not specifically target transcription units and transcription start sites. Comparing the integration sites of HTLV-1 with those of ASLV, HIV, simian immunodeficiency virus, MLV, and foamy virus, we show that global and local integration site preferences correlate with the sequence/structure of virus-encoded integrases, supporting the idea that integrase is the major determinant of retroviral integration site selection. Our results suggest that the global integration profiles of other retroviruses could be predicted from phylogenetic comparisons of the integrase proteins. Our results show that retroviruses that engender different insertional mutagenesis risks can have similar integration profiles. JF - Journal of virology AU - Derse, David AU - Crise, Bruce AU - Li, Yuan AU - Princler, Gerald AU - Lum, Nicole AU - Stewart, Claudia AU - McGrath, Connor F AU - Hughes, Stephen H AU - Munroe, David J AU - Wu, Xiaolin AD - HIV Drug Resistance Program, Laboratory of Molecular Technology, SAIC-Frederick, Inc., NCI-Frederick, 915 Toll House Avenue, Frederick, MD 21702, USA. Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 6731 EP - 6741 VL - 81 IS - 12 SN - 0022-538X, 0022-538X KW - Index Medicus KW - Phylogeny KW - HeLa Cells KW - Models, Genetic KW - Humans KW - CpG Islands KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - Cluster Analysis KW - Chromosome Mapping KW - Cell Line KW - Genome, Human KW - Human T-lymphotropic virus 1 -- metabolism KW - Virus Integration KW - Retroviridae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70551414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Human+T-cell+leukemia+virus+type+1+integration+target+sites+in+the+human+genome%3A+comparison+with+those+of+other+retroviruses.&rft.au=Derse%2C+David%3BCrise%2C+Bruce%3BLi%2C+Yuan%3BPrincler%2C+Gerald%3BLum%2C+Nicole%3BStewart%2C+Claudia%3BMcGrath%2C+Connor+F%3BHughes%2C+Stephen+H%3BMunroe%2C+David+J%3BWu%2C+Xiaolin&rft.aulast=Derse&rft.aufirst=David&rft.date=2007-06-01&rft.volume=81&rft.issue=12&rft.spage=6731&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-11 N1 - Date created - 2007-05-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 2000 Mar;74(5):2305-12 [10666261] Nature. 2005 Feb 10;433(7026):561 [15703711] Mol Cell Biol. 2001 Apr;21(7):2393-403 [11259588] J Virol. 2001 Sep;75(18):8461-8 [11507191] Cell. 2002 Aug 23;110(4):521-9 [12202041] Mol Ther. 2002 Nov;6(5):570-1 [12409254] Eukaryot Cell. 2002 Feb;1(1):44-55 [12455970] J Biol Chem. 2003 Jan 3;278(1):372-81 [12407101] N Engl J Med. 2003 Jan 16;348(3):255-6 [12529469] Science. 2003 Jun 13;300(5626):1749-51 [12805549] J Virol. 2005 Apr;79(8):5211-4 [15795304] Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6103-7 [15802467] Hum Gene Ther. 2005 Apr;16(4):522-6 [15871683] Blood. 2005 Aug 1;106(3):1048-53 [15840694] J Virol. 2005 Oct;79(19):12199-204 [16160146] Nat Rev Microbiol. 2005 Nov;3(11):848-58 [16175173] Nat Med. 2005 Dec;11(12):1287-9 [16311605] J Virol. 2006 Jan;80(1):451-9 [16352569] Genome Res. 2006 Jan;16(1):123-31 [16344561] Mol Ther. 2006 Feb;13(2):366-73 [16325473] Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1498-503 [16428288] J Gen Virol. 2006 May;87(Pt 5):1339-47 [16603537] PLoS Pathog. 2006 Jun;2(6):e60 [16789841] Mol Ther. 2006 Aug;14(2):218-25 [16647883] J Virol. 2006 Sep;80(17):8820-3 [16912328] J Virol. 2006 Oct;80(19):9497-510 [16973554] Science. 2006 Oct 20;314(5798):461-4 [16959972] Nucleic Acids Res. 2007;35(1):113-24 [17158150] Genome Res. 2003 Sep;13(9):1984-97 [12952871] Science. 2003 Oct 17;302(5644):415-9 [14564000] Cell. 2003 Oct 17;115(2):135-8 [14567911] Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):992-7 [14732688] J Hum Genet. 2004;49(3):154-65 [14991527] Cancer Sci. 2004 Apr;95(4):306-10 [15072587] Brief Bioinform. 2004 Jun;5(2):150-63 [15260895] J Virol. 2004 Sep;78(17):9524-37 [15308744] PLoS Biol. 2004 Aug;2(8):E234 [15314653] Front Biosci. 2004 Sep 1;9:3187-208 [15353349] J Virol. 2004 Nov;78(21):11656-63 [15479807] Nature. 1986 May 15-21;321(6067):209-13 [2423876] Annu Rev Biochem. 1988;57:159-97 [3052270] Curr Top Microbiol Immunol. 1990;157:1-18 [2203607] Mol Cell Biol. 1990 Dec;10(12):6791-8 [2174117] EMBO J. 1992 Jan;11(1):291-303 [1310932] Cell. 1992 May 29;69(5):769-80 [1317268] Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5532-6 [1319063] Genomics. 1992 Aug;13(4):1095-107 [1505946] Genes Dev. 1994 Jun 15;8(12):1473-87 [7926746] Biokhimiia. 1995 Aug;60(8):1221-30 [7578577] Annu Rev Immunol. 1997;15:15-37 [9143680] Nat Med. 1998 Mar;4(3):354-7 [9500613] J Virol. 1999 Jun;73(6):5186-90 [10233986] Lancet. 1999 Jun 5;353(9168):1951-8 [10371587] Cell Mol Life Sci. 2004 Oct;61(19-20):2588-96 [15526164] PLoS Biol. 2004 Dec;2(12):e423 [15550989] J Biol Chem. 2004 Dec 31;279(53):55570-7 [15475359] AIDS Res Hum Retroviruses. 2000 Nov 1;16(16):1653-9 [11080806] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Increases in expression of 14-3-3 eta and 14-3-3 zeta transcripts during neuroprotection induced by delta9-tetrahydrocannabinol in AF5 cells. AN - 70547093; 17455326 AB - The molecular mechanisms involved in N-methyl-D-aspartate (NMDA)-induced cell death and Delta9-tetrahydrocannabinol (THC)-induced neuroprotection were investigated in vitro with an AF5 neural progenitor cell line model. By microarray analysis, Ywhah, CK1, Hsp60, Pdcd 4, and Pdcd 7 were identified as being strongly regulated by both NMDA toxicity and THC neuroprotection. The 14-3-3 eta (14-3-3eta; gene symbol Ywhah) and 14-3-3 zeta (14-3-3zeta; gene symbol Ywhaz) transcripts were deceased by NMDA treatment and increased by THC treatment prior to NMDA, as measured by cDNA microarray analysis and quantitative real-time RT-PCR. Other 14-3-3 isoforms were unchanged. Whereas up-regulation of 14-3-3zeta expression was observed 30 min after treatment with THC plus NMDA, down-regulation by NMDA alone was not seen until 16 hr after treatment. By Western blotting, THC increased 14-3-3 protein only in cells that were also treated with NMDA. Overexpression of 14-3-3eta or 14-3-3zeta by transient plasmid transfection increased 14-3-3 protein levels and decreased NMDA-induced cell death. These data suggest that increases in 14-3-3 proteins mediate THC-induced neuroprotection under conditions of NMDA-induced cellular stress. Copyright (c) 2007 Wiley-Liss, Inc. JF - Journal of neuroscience research AU - Chen, Jia AU - Lee, Chun-Ting AU - Errico, Stacie L AU - Becker, Kevin G AU - Freed, William J AD - Development and Plasticity Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA. jichen@mail.nih.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 1724 EP - 1733 VL - 85 IS - 8 SN - 0360-4012, 0360-4012 KW - 14-3-3 Proteins KW - 0 KW - Neuroprotective Agents KW - N-Methylaspartate KW - 6384-92-5 KW - Dronabinol KW - 7J8897W37S KW - Index Medicus KW - Rats KW - Animals KW - Oligonucleotide Array Sequence Analysis KW - Transfection KW - Plasmids KW - Mesencephalon -- cytology KW - Cell Line KW - N-Methylaspartate -- physiology KW - Dronabinol -- pharmacology KW - 14-3-3 Proteins -- biosynthesis KW - N-Methylaspartate -- toxicity KW - N-Methylaspartate -- antagonists & inhibitors KW - 14-3-3 Proteins -- genetics KW - Neuroprotective Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70547093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroscience+research&rft.atitle=Increases+in+expression+of+14-3-3+eta+and+14-3-3+zeta+transcripts+during+neuroprotection+induced+by+delta9-tetrahydrocannabinol+in+AF5+cells.&rft.au=Chen%2C+Jia%3BLee%2C+Chun-Ting%3BErrico%2C+Stacie+L%3BBecker%2C+Kevin+G%3BFreed%2C+William+J&rft.aulast=Chen&rft.aufirst=Jia&rft.date=2007-06-01&rft.volume=85&rft.issue=8&rft.spage=1724&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroscience+research&rft.issn=03604012&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-05 N1 - Date created - 2007-05-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: EMBO J. 2000 Feb 1;19(3):349-58 [10654934] Neurosci Res. 2006 Sep;56(1):61-72 [16797759] Mol Cell. 2000 Jul;6(1):41-51 [10949026] Physiol Genomics. 2000 Sep 8;3(3):175-85 [11015613] Nat Genet. 2001 May;28(1):17-8 [11326268] Brain Res Bull. 2001 Jul 15;55(5):641-50 [11576761] Bioessays. 2001 Oct;23(10):936-46 [11598960] J Biol Chem. 2001 Nov 30;276(48):45193-200 [11577088] Exp Neurol. 2002 Jun;175(2):318-37 [12061863] Biochem Soc Trans. 2002 Aug;30(4):360-5 [12196095] Chem Phys Lipids. 2002 Dec 31;121(1-2):257-66 [12505705] Mol Psychiatry. 2003 Feb;8(2):156-66 [12610648] Mol Cell Biol. 2003 Apr;23(7):2362-78 [12640121] J Mol Diagn. 2003 May;5(2):73-81 [12707371] Curr Mol Med. 2003 Aug;3(5):437-46 [12942997] Brain Res Dev Brain Res. 2003 Dec 30;147(1-2):153-62 [14741760] Exp Cell Res. 2004 Apr 1;294(2):581-91 [15023544] FEBS Lett. 1993 Oct 4;331(3):296-303 [8375512] Brain Res Mol Brain Res. 1994 Aug;25(1-2):113-21 [7984035] Mol Neurobiol. 1995 Aug-Dec;11(1-3):223-30 [8561965] Genomics. 1996 Aug 15;36(1):63-9 [8812417] Science. 1997 Jan 3;275(5296):90-4 [8974401] J Biol Chem. 1997 May 23;272(21):13717-24 [9153224] Cell Tissue Res. 1998 Feb;291(2):175-89 [9426306] Cell. 1999 Mar 19;96(6):857-68 [10102273] Am J Med Genet. 1999 Apr 16;88(2):164-7 [10206237] J Pharmacol Exp Ther. 1999 Jun;289(3):1559-63 [10336553] Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8511-5 [10411906] J Cereb Blood Flow Metab. 2005 Mar;25(3):338-47 [15660102] Brain Res Mol Brain Res. 2005 Apr 4;134(2):215-25 [15836919] Neurosci Lett. 2005 Dec 2;389(2):99-103 [16098661] Handb Exp Pharmacol. 2006;(172):171-98 [16610360] Acta Neuropathol. 2006 May;111(5):413-21 [16557393] Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9127-32 [10922068] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Peroxisome proliferator-activated receptor alpha regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation. AN - 70537401; 17438130 AB - Activation of peroxisome proliferator-activated receptor alpha (PPARalpha) leads to hepatocellular proliferation and liver carcinomas. The early events mediating these effects are unknown. A novel mechanism by which PPARalpha regulates gene expression and hepatocellular proliferation was uncovered. MicroRNA (miRNA) expression profiling demonstrated that activated PPARalpha was a major regulator of hepatic miRNA expression. Of particular interest, let-7C, an miRNA important in cell growth, was inhibited following 4-h treatment and 2-week and 11-month sustained treatment with the potent PPARalpha agonist Wy-14,643 in wild-type mice. let-7C was shown to target c-myc via direct interaction with the 3' untranslated region of c-myc. The PPARalpha-mediated induction of c-myc via let-7C subsequently increased expression of the oncogenic mir-17-92 cluster; these events did not occur in Pparalpha-null mice. Overexpression of let-7C decreased c-myc and mir-17 and suppressed the growth of Hepa-1 cells. Furthermore, using the human PPARalpha-expressing mouse model, which is responsive to Wy-14,643 effects on beta-oxidation and serum triglycerides but resistant to hepatocellular proliferation and tumorigenesis, we demonstrated a critical role for let-7C in liver oncogenesis. Wy-14,643 treatment did not inhibit let-7C or induce c-myc and mir-17 expression. These observations reveal a let-7C signaling cascade critical for PPARalpha agonist-induced liver proliferation and tumorigenesis. JF - Molecular and cellular biology AU - Shah, Yatrik M AU - Morimura, Keiichirou AU - Yang, Qian AU - Tanabe, Tomotaka AU - Takagi, Mitsuhiro AU - Gonzalez, Frank J AD - National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 4238 EP - 4247 VL - 27 IS - 12 SN - 0270-7306, 0270-7306 KW - MicroRNAs KW - 0 KW - PPAR alpha KW - Peroxisome Proliferators KW - Proto-Oncogene Proteins c-myc KW - Pyrimidines KW - pirinixic acid KW - 86C4MRT55A KW - Luciferases KW - EC 1.13.12.- KW - Index Medicus KW - Animals KW - Luciferases -- metabolism KW - Pyrimidines -- pharmacology KW - Proto-Oncogene Proteins c-myc -- genetics KW - Peroxisome Proliferators -- pharmacology KW - Cell Line, Tumor KW - Mice KW - Cell Proliferation KW - Mice, Knockout KW - Proto-Oncogene Proteins c-myc -- biosynthesis KW - Gene Expression Profiling KW - Models, Genetic KW - Genes, Reporter KW - Gene Expression Regulation KW - Liver Neoplasms -- pathology KW - MicroRNAs -- metabolism KW - Carcinoma, Hepatocellular -- etiology KW - Carcinoma, Hepatocellular -- pathology KW - PPAR alpha -- metabolism KW - Liver Neoplasms -- physiopathology KW - Carcinoma, Hepatocellular -- physiopathology KW - Liver Neoplasms -- etiology KW - Signal Transduction KW - PPAR alpha -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70537401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Peroxisome+proliferator-activated+receptor+alpha+regulates+a+microRNA-mediated+signaling+cascade+responsible+for+hepatocellular+proliferation.&rft.au=Shah%2C+Yatrik+M%3BMorimura%2C+Keiichirou%3BYang%2C+Qian%3BTanabe%2C+Tomotaka%3BTakagi%2C+Mitsuhiro%3BGonzalez%2C+Frank+J&rft.aulast=Shah&rft.aufirst=Yatrik&rft.date=2007-06-01&rft.volume=27&rft.issue=12&rft.spage=4238&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-09 N1 - Date created - 2007-05-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 1995 Jun;15(6):3012-22 [7539101] Science. 2004 Sep 3;305(5689):1437-41 [15284456] Ann N Y Acad Sci. 1996 Dec 27;804:573-87 [8993574] Carcinogenesis. 1997 Nov;18(11):2029-33 [9395198] J Natl Cancer Inst. 1998 Nov 18;90(22):1702-9 [9827524] Cell Prolif. 1994 May;27(5):269-78 [10465011] Nature. 2004 Nov 11;432(7014):235-40 [15531877] RNA. 2004 Dec;10(12):1957-66 [15525708] Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3627-32 [15738415] Cell. 2005 Mar 11;120(5):635-47 [15766527] Nature. 2005 Jun 9;435(7043):828-33 [15944707] Nature. 2005 Jun 9;435(7043):839-43 [15944709] Nature. 2005 Jul 14;436(7048):214-20 [15951802] Cell. 2005 Aug 26;122(4):553-63 [16122423] Nature. 2005 Sep 29;437(7059):759-63 [16127449] J Mol Med (Berl). 2005 Oct;83(10):774-85 [15976920] Int J Toxicol. 2005 Sep-Oct;24(5):301-11 [16257850] Int J Toxicol. 2005 Sep-Oct;24(5):313-25 [16257851] Int J Toxicol. 2005 Sep-Oct;24(5):327-39 [16257852] Mutat Res. 2000 Mar 17;448(2):159-77 [10725470] Cell. 2001 Dec 28;107(7):823-6 [11779458] Nature. 1980 Jan 24;283(5745):397-8 [6766207] Nature. 1987 May 28-Jun 3;327(6120):293-7 [3587348] N Engl J Med. 1988 Sep 1;319(9):525-32 [2841597] Biochem Biophys Res Commun. 1990 Dec 31;173(3):855-61 [2268348] Genes Chromosomes Cancer. 1990 Jul;2(2):159-62 [2278970] Cancer Res. 1993 Apr 15;53(8):1719-23 [8467484] Hum Exp Toxicol. 1994 Nov;13 Suppl 2:S1-117 [7857698] Cancer Res. 2005 Nov 1;65(21):9628-32 [16266980] Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16426-31 [16260724] Genes Dev. 2006 Mar 1;20(5):515-24 [16510870] Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4034-9 [16495412] Physiol Rev. 2006 Apr;86(2):465-514 [16601267] Carcinogenesis. 2006 May;27(5):1074-80 [16377806] Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8721-6 [16731620] Curr Opin Investig Drugs. 2006 Jun;7(6):560-4 [16784027] Cold Spring Harb Symp Quant Biol. 2005;70:461-7 [16869784] Nat Genet. 2006 Sep;38(9):1060-5 [16878133] Mamm Genome. 2006 Oct;17(10):1033-41 [17019647] Nat Methods. 2006 Nov;3(11):881-6 [17060911] Nat Genet. 2006 Nov;38(11):1289-97 [17013392] Mol Cell. 2007 Jan 12;25(1):57-70 [17218271] Dev Biol. 2007 Feb 1;302(1):1-12 [16989803] Carcinogenesis. 2007 Jun;28(6):1171-7 [17331954] Curr Biol. 2002 Apr 30;12(9):735-9 [12007417] EMBO J. 2002 Sep 2;21(17):4663-70 [12198168] Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15524-9 [12434020] Int J Oncol. 2003 Mar;22(3):469-80 [12579299] Toxicol Pathol. 2003 May-Jun;31(3):295-303 [12746117] Cell Cycle. 2003 Jul-Aug;2(4):333-8 [12851485] Genome Biol. 2003;4(10):R69 [14519204] Mol Cancer Res. 2003 Oct;1(12):882-91 [14573789] Oncogene. 2003 Dec 8;22(56):8999-9006 [14663478] Cell. 2003 Dec 26;115(7):787-98 [14697198] Am J Cardiovasc Drugs. 2001;1(6):455-66 [14728004] Cell. 2004 Jan 23;116(2):281-97 [14744438] Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2999-3004 [14973191] Genes Dev. 2004 Mar 1;18(5):504-11 [15014042] Cancer Res. 2004 Jun 1;64(11):3753-6 [15172979] Cancer Res. 2004 Jun 1;64(11):3849-54 [15172993] Essays Biochem. 2004;40:89-104 [15242341] Mol Cell. 2004 Jul 23;15(2):185-97 [15260970] Prog Clin Biol Res. 1995;391:49-70 [8532737] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evolution and diversification of lamprey antigen receptors: evidence for involvement of an AID-APOBEC family cytosine deaminase. AN - 70532443; 17468760 AB - The variable lymphocyte receptors (VLRs) of jawless vertebrates such as lamprey and hagfish are composed of highly diverse modular leucine-rich repeats. Each lymphocyte assembles a unique VLR by rearrangement of the germline gene. In the lamprey genome, we identify here about 850 distinct cassettes encoding leucine-rich repeat modules that serve as sequence templates for the hypervariable VLR repertoires. The data indicate a gene conversion-like process in VLR diversification. Genomic analysis suggested a link between the VLR and platelet glycoprotein receptors. Lamprey lymphocytes express two putative deaminases of the AID-APOBEC family that may be involved in VLR diversification, as indicated by in vitro mutagenesis and recombination assays. Vertebrate acquired immunity could have therefore originated from lymphocyte receptor diversification by an ancestral AID-like DNA cytosine deaminase. JF - Nature immunology AU - Rogozin, Igor B AU - Iyer, Lakshminarayan M AU - Liang, Lizhi AU - Glazko, Galina V AU - Liston, Victoria G AU - Pavlov, Youri I AU - Aravind, L AU - Pancer, Zeev AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA. Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 647 EP - 656 VL - 8 IS - 6 SN - 1529-2908, 1529-2908 KW - Receptors, Antigen KW - 0 KW - Cytosine Deaminase KW - EC 3.5.4.1 KW - Index Medicus KW - Phylogeny KW - Animals KW - Base Sequence KW - Sequence Alignment KW - Genome -- genetics KW - Humans KW - Molecular Sequence Data KW - Mutation -- genetics KW - Amino Acid Sequence KW - Receptors, Antigen -- genetics KW - Lampreys -- metabolism KW - Lampreys -- immunology KW - Cytosine Deaminase -- metabolism KW - Receptors, Antigen -- immunology KW - Receptors, Antigen -- chemistry KW - Cytosine Deaminase -- classification KW - Evolution, Molecular UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70532443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+immunology&rft.atitle=Evolution+and+diversification+of+lamprey+antigen+receptors%3A+evidence+for+involvement+of+an+AID-APOBEC+family+cytosine+deaminase.&rft.au=Rogozin%2C+Igor+B%3BIyer%2C+Lakshminarayan+M%3BLiang%2C+Lizhi%3BGlazko%2C+Galina+V%3BListon%2C+Victoria+G%3BPavlov%2C+Youri+I%3BAravind%2C+L%3BPancer%2C+Zeev&rft.aulast=Rogozin&rft.aufirst=Igor&rft.date=2007-06-01&rft.volume=8&rft.issue=6&rft.spage=647&rft.isbn=&rft.btitle=&rft.title=Nature+immunology&rft.issn=15292908&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-20 N1 - Date created - 2007-05-21 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - EF528600; 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EF094782; EF094781; EF094594; EF094595; EF094592; EF094593; EF094590; EF094591; EF094598; EF094599; EF094596; EF094597; EF094799; EF094798; EF094797; EF094796; EF094795; EF094794; EF094793; EF094792; EF094791; EF094790; EF464171; EF464172; EF464173; EF464174; EF464175; EF464176; EF528769; EF528770; EF528771; EF528776; EF528777; EF528778; EF528779; EF528772; EF528773; EF528774; EF528775; EF528781; EF528782; EF528780; EF528789; EF528787; EF528788; EF528785; EF528786; EF528783; EF528784; EF528790; EF528791; EF528792; EF528793; EF528794; EF528795; EF528796; EF528797; EF528798; EF528799; EF529071; EF529070; EF529076; EF529077; EF529078; EF529079; EF529072; EF529073; EF529074; EF529075; EF529060; EF529069; EF529067; EF529068; EF529065; EF529066; EF529063; EF529064; EF529061; EF529062; EF529091; EF529090; EF529093; EF529092; EF529094; EF529095; EF529096; EF529097; EF529098; EF529099; EF529082; EF529081; EF529080; EF529085; EF529086; EF529083; EF529084; EF529089; EF529087; EF529088 N1 - SuppNotes - Comment In: Nat Immunol. 2007 Jun;8(6):551-3 [17514205] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hypolocomotion, anxiety and serotonin syndrome-like behavior contribute to the complex phenotype of serotonin transporter knockout mice. AN - 70521767; 16939636 AB - Although mice with a targeted disruption of the serotonin transporter (SERT) have been studied extensively using various tests, their complex behavioral phenotype is not yet fully understood. Here we assess in detail the behavior of adult female SERT wild type (+/+), heterozygous (+/-) and knockout (-/-) mice on an isogenic C57BL/6J background subjected to a battery of behavioral paradigms. Overall, there were no differences in the ability to find food or a novel object, nest-building, self-grooming and its sequencing, and horizontal rod balancing, indicating unimpaired sensory functions, motor co-ordination and behavioral sequencing. In contrast, there were striking reductions in exploration and activity in novelty-based tests (novel object, sticky label and open field tests), accompanied by pronounced thigmotaxis, suggesting that combined hypolocomotion and anxiety (rather than purely anxiety) influence the SERT -/- behavioral phenotype. Social interaction behaviors were also markedly reduced. In addition, SERT -/- mice tended to move close to the ground, frequently displayed spontaneous Straub tail, tics, tremor and backward gait - a phenotype generally consistent with 'serotonin syndrome'-like behavior. In line with replicated evidence of much enhanced serotonin availability in SERT -/- mice, this serotonin syndrome-like state may represent a third factor contributing to their behavioral profile. An understanding of the emerging complexity of SERT -/- mouse behavior is crucial for a detailed dissection of their phenotype and for developing further neurobehavioral models using these mice. JF - Genes, brain, and behavior AU - Kalueff, A V AU - Fox, M A AU - Gallagher, P S AU - Murphy, D L AD - Laboratory of Clinical Science, Intramural Research Program, National Institute of Mental Health (NIMH), Bethesda, MD, USA. kalueva@mail.nih.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 389 EP - 400 VL - 6 IS - 4 SN - 1601-1848, 1601-1848 KW - Serotonin Plasma Membrane Transport Proteins KW - 0 KW - Index Medicus KW - Motor Activity -- genetics KW - Genetics, Behavioral KW - Animals KW - Stereotyped Behavior -- physiology KW - Sensation -- genetics KW - Social Behavior KW - Mice, Inbred C57BL KW - Motor Activity -- physiology KW - Mice KW - Statistics, Nonparametric KW - Female KW - Mice, Knockout KW - Anxiety -- genetics KW - Hypokinesia -- genetics KW - Exploratory Behavior -- physiology KW - Serotonin Syndrome -- genetics KW - Serotonin Plasma Membrane Transport Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70521767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genes%2C+brain%2C+and+behavior&rft.atitle=Hypolocomotion%2C+anxiety+and+serotonin+syndrome-like+behavior+contribute+to+the+complex+phenotype+of+serotonin+transporter+knockout+mice.&rft.au=Kalueff%2C+A+V%3BFox%2C+M+A%3BGallagher%2C+P+S%3BMurphy%2C+D+L&rft.aulast=Kalueff&rft.aufirst=A&rft.date=2007-06-01&rft.volume=6&rft.issue=4&rft.spage=389&rft.isbn=&rft.btitle=&rft.title=Genes%2C+brain%2C+and+behavior&rft.issn=16011848&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-17 N1 - Date created - 2007-05-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Concentration-dependent synergy and antagonism within a triple antifungal drug combination against Aspergillus species: analysis by a new response surface model. AN - 70520841; 17387150 AB - Triple antifungal combinations are used against refractory invasive aspergillosis without an adequate understanding of their pharmacodynamic interactions. We initially studied the in vitro triple combination of voriconazole, amphotericin B, and caspofungin against Aspergillus fumigatus, A. flavus, and A. terreus by a spectrophotometric microdilution broth method after 48 h of incubation. We then analyzed these results with a recently described nonlinear mixture response surface E(max)-based model modified to assess pharmacodynamic interactions at various growth levels. The new model allows flexibility in all four parameters of the E(max) model and is able to describe complex pharmacodynamic interactions. Concentration-dependent pharmacodynamic interactions were found within the triple antifungal combination. At the 50% growth level, synergy (median interaction indices of 0.43 to 0.82) was observed at low concentrations of voriconazole (<0.03 mg/liter) and amphotericin B ( A transversion that encodes an arginine to histidine substitution (R96H). This mutation is predicted to disrupt furin-mediated proteolytic cleavage of pro-endothelin that is necessary to form biologically active EDN3. This mutation is novel among human and mouse EDN3 mutants, is the first reported EDN3 ENU mutant, and is the second reported EDN3 point mutation. This study demonstrates the power of using ENU mutagenesis screens to generate new animal models of human disease, and expands the spectrum of EDN3 mutant alleles. JF - Pigment cell research AU - Matera, Ivana AU - Cockroft, Jody L AU - Moran, Jennifer L AU - Beier, David R AU - Goldowitz, Dan AU - Pavan, William J AD - Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20855, USA. Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 210 EP - 215 VL - 20 IS - 3 SN - 0893-5785, 0893-5785 KW - Endothelin-3 KW - 0 KW - Histidine KW - 4QD397987E KW - Arginine KW - 94ZLA3W45F KW - Ethylnitrosourea KW - P8M1T4190R KW - Index Medicus KW - Histidine -- chemistry KW - Genetic Linkage KW - Pigmentation KW - Animals KW - Arginine -- chemistry KW - Humans KW - Point Mutation KW - Mice KW - Chromosome Mapping KW - Waardenburg Syndrome -- diagnosis KW - Endothelin-3 -- genetics KW - Ethylnitrosourea -- toxicity KW - Disease Models, Animal KW - Gene Expression Regulation KW - Endothelin-3 -- physiology KW - Mutation KW - Waardenburg Syndrome -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70508333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pigment+cell+research&rft.atitle=A+mouse+model+of+Waardenburg+syndrome+type+IV+resulting+from+an+ENU-induced+mutation+in+endothelin+3.&rft.au=Matera%2C+Ivana%3BCockroft%2C+Jody+L%3BMoran%2C+Jennifer+L%3BBeier%2C+David+R%3BGoldowitz%2C+Dan%3BPavan%2C+William+J&rft.aulast=Matera&rft.aufirst=Ivana&rft.date=2007-06-01&rft.volume=20&rft.issue=3&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Pigment+cell+research&rft.issn=08935785&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-20 N1 - Date created - 2007-05-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Strain differences in lithium attenuation of d-amphetamine-induced hyperlocomotion: a mouse model for the genetics of clinical response to lithium. AN - 70505388; 17151598 AB - Lithium attenuation of stimulant-induced hyperlocomotion is a rodent model that may be useful both to understand the mechanism of the therapeutic action of lithium and to develop novel lithium-mimetic compounds. To lay the foundation for future investigations into the neurobiology and genetics of lithium as a therapeutic agent, we studied the effect of lithium on d-amphetamine-induced hyperlocomotion in 12 (3 outbred) mouse strains. In our initial screening, mice received either (1) no drugs, (2) LiCl only, (3) d-amphetamine only, or (4) d-amphetamine and LiCl. Whereas there was no significant effect of LiCl alone on locomotion in any strain, there was a large degree of strain variation in the effects of LiCl combined with d-amphetamine. LiCl attenuated d-amphetamine-induced hyperlocomotion in C57BL/6J, C57BL/6Tac, Black Swiss, and CBA/J mice, whereas CD-1, FVB/NJ, SWR/J, and NIH Swiss mice, which were responsive to d-amphetamine, showed no significant effect of LiCl. d-Amphetamine-induced hyperlocomotion in the C3H/HeJ strain was increased by pretreatment with lithium. A subset of strains were treated for 4 weeks with lithium carbonate before the d-amphetamine challenge, and in each of these strains, lithium produced effects identical to those seen following acute administration. Strain responsiveness to lithium was not dependent upon the dose of either d-amphetamine or LiCl. Further, the results are not explained by brain lithium levels, which suggests that these behavioral responses to lithium are under the control of inherent genetic or other biological mechanisms specific to the effects of lithium on brain function. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Gould, Todd D AU - O'Donnell, Kelley C AU - Picchini, Alyssa M AU - Manji, Husseini K AD - Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, HHS, Bethesda, MD 20892-3711, USA. gouldt@mail.nih.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 1321 EP - 1333 VL - 32 IS - 6 SN - 0893-133X, 0893-133X KW - Antimanic Agents KW - 0 KW - Central Nervous System Stimulants KW - Lithium Chloride KW - G4962QA067 KW - Dextroamphetamine KW - TZ47U051FI KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Dose-Response Relationship, Drug KW - Data Interpretation, Statistical KW - Motor Activity -- drug effects KW - Mice KW - Brain -- metabolism KW - Species Specificity KW - Male KW - Lithium Chloride -- pharmacokinetics KW - Central Nervous System Stimulants -- pharmacology KW - Antimanic Agents -- pharmacokinetics KW - Hyperkinesis -- chemically induced KW - Central Nervous System Stimulants -- antagonists & inhibitors KW - Antimanic Agents -- therapeutic use KW - Dextroamphetamine -- antagonists & inhibitors KW - Hyperkinesis -- prevention & control KW - Lithium Chloride -- therapeutic use KW - Hyperkinesis -- genetics KW - Dextroamphetamine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70505388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Strain+differences+in+lithium+attenuation+of+d-amphetamine-induced+hyperlocomotion%3A+a+mouse+model+for+the+genetics+of+clinical+response+to+lithium.&rft.au=Gould%2C+Todd+D%3BO%27Donnell%2C+Kelley+C%3BPicchini%2C+Alyssa+M%3BManji%2C+Husseini+K&rft.aulast=Gould&rft.aufirst=Todd&rft.date=2007-06-01&rft.volume=32&rft.issue=6&rft.spage=1321&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-27 N1 - Date created - 2007-05-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Achaete-scute homolog-1 linked to remodeling and preneoplasia of pulmonary epithelium. AN - 70501531; 17507989 AB - The basic helix-loop-helix protein achaete-scute homolog-1 (ASH1) is involved in lung neuroendocrine (NE) differentiation and tumor promotion in SV40 transgenic mice. Constitutive expression of human ASH-1 (hASH1) in mouse lung results in hyperplasia and remodeling that mimics bronchiolization of alveoli (BOA), a potentially premalignant lesion of human lung carcinomas. We now show that this is due to sustained cellular proliferation in terminal bronchioles and resistance to apoptosis. Throughout the airway epithelium the expression of anti-apoptotic Bcl-2 and c-Myb was increased and Akt/mTOR pathway activated. Moreover, the expression of matrix metalloproteases (MMPs) including MMP7 was specifically enhanced at the bronchiolo-alveolar duct junction and BOA suggesting that MMPs play a key role in this microenvironment during remodeling. We also detected MMP7 in 70% of human BOA lesions. Knockdown of hASH1 gene in human lung cancer cells in vitro suppressed growth by increasing apoptosis. We also show that forced expression of hASH1 in immortalized human bronchial epithelial cells decreases apoptosis. We conclude that the impact of hASH1 is not limited to cells with NE phenotype. Rather, constitutive expression of hASH1 in lung epithelium promotes remodeling through multiple pathways that are commonly activated during lung carcinogenesis. The collective results suggest a novel model of BOA formation via hASH1-induced suppression of the apoptotic pathway. Our study yields a promising new preclinical tool for chemoprevention of peripheral lung carcinomas. JF - Laboratory investigation; a journal of technical methods and pathology AU - Wang, Xiao-Yang AU - Dakir, El Habib AU - Naizhen, Xu AU - Jensen-Taubman, Sandra M AU - DeMayo, Francesco J AU - Linnoila, R Ilona AD - Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 527 EP - 539 VL - 87 IS - 6 SN - 0023-6837, 0023-6837 KW - ASH1L protein, human KW - 0 KW - Adaptor Proteins, Signal Transducing KW - Apoptosis Regulatory Proteins KW - Bag3 protein, mouse KW - Basic Helix-Loop-Helix Transcription Factors KW - Carrier Proteins KW - DNA-Binding Proteins KW - SCGB1A1 protein, human KW - Scgb1a1 protein, mouse KW - Transcription Factors KW - Uteroglobin KW - 9060-09-7 KW - Oncogene Protein v-akt KW - EC 2.7.11.1 KW - MMP7 protein, human KW - EC 3.4.24.23 KW - Matrix Metalloproteinase 7 KW - Index Medicus KW - Uteroglobin -- metabolism KW - Pulmonary Alveoli -- pathology KW - Hyperplasia -- pathology KW - Animals KW - Apoptosis KW - Carrier Proteins -- metabolism KW - Genes, myb KW - Uteroglobin -- genetics KW - Humans KW - Lung -- cytology KW - Mice KW - Cell Line, Tumor KW - Mice, Transgenic KW - Basic Helix-Loop-Helix Transcription Factors -- genetics KW - Bronchi -- pathology KW - Models, Biological KW - Pulmonary Alveoli -- metabolism KW - Oncogene Protein v-akt -- metabolism KW - Hyperplasia -- genetics KW - Matrix Metalloproteinase 7 -- metabolism KW - Basic Helix-Loop-Helix Transcription Factors -- metabolism KW - Bronchi -- metabolism KW - Cell Line, Transformed KW - Cell Transformation, Viral KW - Carcinoma, Small Cell -- pathology KW - Lung Neoplasms -- etiology KW - Precancerous Conditions KW - Transcription Factors -- metabolism KW - Lung Neoplasms -- genetics KW - Epithelium -- pathology KW - Carcinoma, Small Cell -- genetics KW - Lung Neoplasms -- pathology KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70501531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.atitle=Achaete-scute+homolog-1+linked+to+remodeling+and+preneoplasia+of+pulmonary+epithelium.&rft.au=Wang%2C+Xiao-Yang%3BDakir%2C+El+Habib%3BNaizhen%2C+Xu%3BJensen-Taubman%2C+Sandra+M%3BDeMayo%2C+Francesco+J%3BLinnoila%2C+R+Ilona&rft.aulast=Wang&rft.aufirst=Xiao-Yang&rft.date=2007-06-01&rft.volume=87&rft.issue=6&rft.spage=527&rft.isbn=&rft.btitle=&rft.title=Laboratory+investigation%3B+a+journal+of+technical+methods+and+pathology&rft.issn=00236837&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-16 N1 - Date created - 2007-05-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - ATR signaling mediates an S-phase checkpoint after inhibition of poly(ADP-ribose) polymerase activity. AN - 70462848; 17292679 AB - Human fibroblasts, capable of expressing a kinase-dead form of ATR (ATRkd), can be sensitized to the cytotoxic effects of methyl methanesulfonate (MMS) by the PARP inhibitor 4-amino-1,8-naphthalimide (4-AN). The combination of MMS+4-AN results in accumulation of cells in S-phase of the cell cycle and activation of Chk1. Inhibition of ATR activity by expression of ATRkd suppresses the S-phase accumulation and partially reverses the Chk1 phosphorylation. The results confirm involvement of an ATR-mediated damage response pathway in the MMS+4-AN-induced S-phase cell cycle checkpoint in human fibroblasts. Consistent with this hypothesis, the inhibitors caffeine and UCN-01 also abrogate the ATR- and Chk1-mediated delay in progression through S-phase. In the absence of ATR-mediated signaling, MMS+4-AN exposure results in a G(2)/M arrest, rather than an S-phase checkpoint. Thus, whereas ATR mediates the S-phase response, it is not critical for arrest of cells in G(2)/M. JF - DNA repair AU - Horton, Julie K AU - Stefanick, Donna F AU - Kedar, Padmini S AU - Wilson, Samuel H AD - Laboratory of Structural Biology, NIEHS, National Institutes of Health, 111 T.W. Alexander Dr., Research Triangle Park, NC 27709, USA. Y1 - 2007/06/01/ PY - 2007 DA - 2007 Jun 01 SP - 742 EP - 750 VL - 6 IS - 6 SN - 1568-7864, 1568-7864 KW - Enzyme Inhibitors KW - 0 KW - Naphthalimides KW - Poly(ADP-ribose) Polymerase Inhibitors KW - Quinolones KW - 4-amino-1,8-naphthalimide KW - 1742-95-6 KW - 1-Naphthylamine KW - 9753I242R5 KW - Methyl Methanesulfonate KW - AT5C31J09G KW - Poly(ADP-ribose) Polymerases KW - EC 2.4.2.30 KW - Index Medicus KW - Phosphorylation KW - Dose-Response Relationship, Drug KW - Humans KW - G2 Phase KW - Flow Cytometry KW - Time Factors KW - Fibroblasts -- metabolism KW - Cell Cycle KW - Cell Division KW - 1-Naphthylamine -- analogs & derivatives KW - S Phase KW - Enzyme Inhibitors -- pharmacology KW - Poly(ADP-ribose) Polymerases -- metabolism KW - 1-Naphthylamine -- pharmacology KW - Signal Transduction KW - Naphthalimides -- pharmacology KW - Quinolones -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70462848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+repair&rft.atitle=ATR+signaling+mediates+an+S-phase+checkpoint+after+inhibition+of+poly%28ADP-ribose%29+polymerase+activity.&rft.au=Horton%2C+Julie+K%3BStefanick%2C+Donna+F%3BKedar%2C+Padmini+S%3BWilson%2C+Samuel+H&rft.aulast=Horton&rft.aufirst=Julie&rft.date=2007-06-01&rft.volume=6&rft.issue=6&rft.spage=742&rft.isbn=&rft.btitle=&rft.title=DNA+repair&rft.issn=15687864&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-07 N1 - Date created - 2007-05-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: DNA Repair (Amst). 2002 Apr 29;1(4):317-33 [12509250] Nucleic Acids Res. 2006;34(6):1685-91 [16556909] Cancer Res. 2004 Apr 1;64(7):2390-6 [15059890] Oncogene. 2004 May 6;23(21):3872-82 [15021907] Bioessays. 2004 Aug;26(8):882-93 [15273990] Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13738-43 [15365186] Cancer Res. 2004 Oct 1;64(19):7139-43 [15466211] J Cell Physiol. 1984 Sep;120(3):335-44 [6746752] Anal Biochem. 1984 Aug 15;141(1):70-3 [6496937] Carcinogenesis. 1985 May;6(5):711-4 [2988807] J Biol Chem. 1992 Jan 25;267(3):1569-75 [1530940] Nature. 1992 Mar 26;356(6367):356-8 [1549180] Trends Biochem Sci. 1995 Oct;20(10):405-11 [8533153] EMBO J. 1998 Jan 2;17(1):159-69 [9427750] J Biol Chem. 1998 Mar 6;273(10):5858-68 [9488723] J Biol Chem. 1998 Aug 14;273(33):21203-9 [9694877] Biochem J. 1999 Sep 1;342 ( Pt 2):249-68 [10455009] Cancer Res. 1999 Sep 1;59(17):4375-82 [10485486] Nature. 2005 Apr 14;434(7035):913-7 [15829966] Nature. 2005 Apr 14;434(7035):917-21 [15829967] J Biol Chem. 2005 Apr 22;280(16):15773-85 [15701627] Cancer Res. 2005 Aug 1;65(15):6874-81 [16061671] Genes Dev. 2000 Feb 15;14(4):397-402 [10691732] Cancer Res. 2000 Apr 15;60(8):2108-12 [10786669] Curr Biol. 2000 Apr 20;10(8):479-82 [10801416] J Mol Biol. 2001 Apr 13;307(5):1235-45 [11292338] J Biol Chem. 2001 Jul 6;276(27):25541-8 [11340072] J Biol Chem. 2001 Dec 21;276(51):47759-62 [11673449] J Biol Chem. 2002 Jan 11;277(2):1599-606 [11700302] Cancer Res. 2002 May 1;62(9):2483-7 [11980637] J Biol Chem. 2002 Aug 23;277(34):31115-23 [12063248] Cell Cycle. 2002 Jul-Aug;1(4):267-72 [12429946] J Biol Chem. 2002 Nov 29;277(48):46609-15 [12244092] DNA Repair (Amst). 2005 Sep 28;4(10):1111-20 [16002346] Trends Mol Med. 2005 Oct;11(10):456-63 [16154385] Cell Cycle. 2006 Jan;5(2):125-8 [16357541] DNA Repair (Amst). 2003 Jan 2;2(1):27-48 [12509266] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Piscine insights into comparisons of anoxia tolerance, ammonia toxicity, stroke and hepatic encephalopathy. AN - 70439348; 17046301 AB - Although the number of fish species that have been studied for both hypoxia/anoxia tolerance and ammonia tolerance are few, there appears to be a correlation between the ability to survive these two insults. After establishing this correlation with examples from the literature, and after examining the role Peter Lutz played in catalyzing this convergent interest in two variables, this article explores potential mechanisms underpinning this correlation. We draw especially on the larger body of information for two human diseases with the same effected organ (brain), namely stroke and hepatic encephalopathy. While several dissimilarities exist between the responses of vertebrates to anoxia and hyperammonemia, one consistent observation in both conditions is an overactivation of NMDA receptors or glutamate neurotoxicity. We propose a glutamate excitotoxicity hypothesis to explain the correlation between ammonia and hypoxia resistance in fish. Furthermore, we suggest several experimental paths to test this hypothesis. JF - Comparative biochemistry and physiology. Part A, Molecular & integrative physiology AU - Walsh, Patrick J AU - Veauvy, Clemence M AU - McDonald, M Danielle AU - Pamenter, Matthew E AU - Buck, Leslie T AU - Wilkie, Michael P AD - NIEHS Marine and Freshwater Biomedical Sciences Center, Division of Marine Biology and Fisheries, Rosenstiel School of Marine and Atmospheric Science, University of Miami, FL 33149, USA. pwalsh@uottawa.ca Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 332 EP - 343 VL - 147 IS - 2 SN - 1095-6433, 1095-6433 KW - Index Medicus KW - Animals KW - Hyperammonemia -- physiopathology KW - Hepatic Encephalopathy -- physiopathology KW - Stroke -- veterinary KW - Hyperammonemia -- veterinary KW - Hepatic Encephalopathy -- veterinary KW - Stroke -- physiopathology KW - Adaptation, Physiological KW - Fishes -- physiology KW - Hypoxia -- veterinary KW - Hypoxia -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70439348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comparative+biochemistry+and+physiology.+Part+A%2C+Molecular+%26+integrative+physiology&rft.atitle=Piscine+insights+into+comparisons+of+anoxia+tolerance%2C+ammonia+toxicity%2C+stroke+and+hepatic+encephalopathy.&rft.au=Walsh%2C+Patrick+J%3BVeauvy%2C+Clemence+M%3BMcDonald%2C+M+Danielle%3BPamenter%2C+Matthew+E%3BBuck%2C+Leslie+T%3BWilkie%2C+Michael+P&rft.aulast=Walsh&rft.aufirst=Patrick&rft.date=2007-06-01&rft.volume=147&rft.issue=2&rft.spage=332&rft.isbn=&rft.btitle=&rft.title=Comparative+biochemistry+and+physiology.+Part+A%2C+Molecular+%26+integrative+physiology&rft.issn=10956433&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-16 N1 - Date created - 2007-04-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Physiol Regul Integr Comp Physiol. 2002 Sep;283(3):R598-603 [12184993] J Physiol. 2002 Sep 15;543(Pt 3):731-7 [12231634] Mar Pollut Bull. 2002;45(1-12):17-23 [12398363] J Neurochem. 2002 Dec;83(5):1226-34 [12437594] Annu Rev Pharmacol Toxicol. 2003;43:335-58 [12540744] Physiol Biochem Zool. 2003 Jan-Feb;76(1):41-51 [12695985] Behav Neurosci. 2003 Jun;117(3):548-54 [12802883] J Exp Biol. 2004 Jan;207(Pt 2):269-83 [14668311] J Exp Biol. 2004 Aug;207(Pt 18):3141-7 [15299035] J Exp Biol. 2004 Aug;207(Pt 18):3155-62 [15299037] Respir Physiol. 1976 Sep;27(3):335-45 [973050] Lab Invest. 1977 Jun;36(6):618-27 [559221] Brain Res. 1979 Feb 2;161(2):303-10 [31966] J Biol Chem. 1979 Jun 25;254(12):4982-92 [36379] Science. 1980 Jul 11;209(4453):308-9 [7384807] Ecotoxicol Environ Saf. 1981 Sep;5(3):316-28 [7297470] Am J Physiol. 1984 Mar;246(3 Pt 2):R277-88 [6367490] Am J Physiol. 1984 Oct;247(4 Pt 2):R740-4 [6093562] Science. 1986 Jan 17;231(4735):234-41 [2417316] Physiol Rev. 1987 Apr;67(2):440-519 [2882529] FEBS Lett. 1992 Jan 13;296(1):67-8 [1346118] Am J Physiol. 1992 Apr;262(4 Pt 2):R712-5 [1314518] Prog Neurobiol. 1992 Aug;39(2):135-53 [1354386] Circ Res. 1992 Nov;71(5):1220-30 [1394882] J Cereb Blood Flow Metab. 1993 Jul;13(4):728-32 [8314926] Brain Res. 1993 Dec 31;632(1-2):225-31 [7908597] Stroke. 1996 Apr;27(4):729-36 [8614939] Am J Physiol. 1996 Oct;271(4 Pt 2):R897-904 [8897979] Neurochem Res. 1996 Oct;21(10):1237-44 [8923486] J Cereb Blood Flow Metab. 1997 Jan;17(1):44-9 [8978385] J Exp Biol. 1997 Jan;200(Pt 2):411-9 [9050250] Neurosci Lett. 1997 Jul 4;229(3):201-3 [9237493] Adv Exp Med Biol. 1997;420:95-111 [9286429] Proc Soc Exp Biol Med. 1999 Nov;222(2):99-112 [10564534] Hepatology. 2000 Mar;31(3):709-15 [10706562] J Neurosci. 2000 May 15;20(10):3522-8 [10804192] Neurochem Int. 2000 Aug-Sep;37(2-3):243-8 [10812209] J Neurophysiol. 2001 Jan;85(1):125-33 [11152713] Comp Biochem Physiol B Biochem Mol Biol. 2001 Dec;130(4):435-59 [11691622] Ment Retard Dev Disabil Res Rev. 2001;7(4):276-9 [11754522] Ment Retard Dev Disabil Res Rev. 2001;7(4):280-6 [11754523] J Exp Biol. 2001 Dec;204(Pt 24):4353-60 [11815659] FASEB J. 2002 May;16(7):739-41 [11923223] Medicine (Baltimore). 2002 May;81(3):240-9 [11997720] Neuroscientist. 2002 Jun;8(3):234-42 [12061503] Glia. 1997 Sep;21(1):124-33 [9298855] Neurosci Lett. 1997 Nov 21;237(2-3):73-6 [9453218] Am J Physiol. 1999 Feb;276(2 Pt 2):H456-63 [9950845] Comp Biochem Physiol B Biochem Mol Biol. 2004 Nov;139(3):311-5 [15544956] Comp Biochem Physiol B Biochem Mol Biol. 2004 Nov;139(3):401-14 [15544964] J Exp Biol. 2004 May;207(Pt 12):1977-83 [15143131] Physiol Biochem Zool. 2004 Sep-Oct;77(5):768-82 [15547795] J Exp Biol. 2005 May;208(Pt 10):1993-2004 [15879078] Neurochem Int. 2005 Jul;47(1-2):31-8 [15908047] Neurochem Int. 2005 Jul;47(1-2):19-30 [15916833] Aquat Toxicol. 2005 Aug 15;74(1):32-46 [15927282] Comp Biochem Physiol A Mol Integr Physiol. 2005 Sep;142(1):50-7 [16139540] Comp Biochem Physiol A Mol Integr Physiol. 2007 Jun;147(2):263-76 [17035057] Comp Biochem Physiol A Mol Integr Physiol. 2007 Jun;147(2):291-9 [17045830] Comp Biochem Physiol A Mol Integr Physiol. 2007 Jun;147(2):277-90 [17049896] Am J Physiol. 1989 Dec;257(6 Pt 2):R1562-4 [2604013] Am J Physiol. 1991 Sep;261(3 Pt 2):H825-9 [1679605] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Direct evidence for rapid and selective induction of tumor neovascular permeability by tumor necrosis factor and a novel derivative, colloidal gold bound tumor necrosis factor. AN - 70346552; 17330231 AB - Tumor necrosis factor (TNF) causes regression of advanced cancers when used in isolation perfusion with melphalan; evidence suggests these effects are mediated via selective yet uncharacterized actions on tumor neovasculature. A novel derivative, colloidal gold bound TNF (cAu-TNF) has been shown to have similar antitumor effects as native TNF with less systemic toxicity in mice. These studies were done to determine their effects on tumor neovasculature, using in vivo video microscopy. Female C57BL/6 mice bearing 20 mm(2) MC38 or LLC tumors that are TNF sensitive and resistant tumors, respectively, had dorsal skinfold chambers implanted. The rate of interstitial accumulation of Texas red fluorescently labeled albumin in tumor and normal vasculature was measured after intravenous TNF, cAu-TNF or PBS. Changes in interstitial fluorescent intensity over time were quantified as a reflection of alterations in vascular permeability. MC38 bearing mice treated with TNF or cAu-TNF demonstrated a rapid, selective and significant increase in tracer accumulation in areas of neovasculature compared to those of normal vasculature. Experiments in LLC tumor bearing mice showed similar results. Monoclonal antibody against tissue factor partially abrogated the effects of TNF on MC38 neovasculature. These data provide direct evidence that TNF and cAu-TNF selectively and rapidly alter permeability in tumor neovasculature; a phenomenon that may be exploited to enhance selective delivery of chemotherapeutics to tumor. JF - International journal of cancer AU - Farma, Jeffrey M AU - Puhlmann, Markus AU - Soriano, Perry A AU - Cox, Derrick AU - Paciotti, Giulio F AU - Tamarkin, Lawrence AU - Alexander, H Richard AD - Surgical Metabolism Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2007/06/01/ PY - 2007 DA - 2007 Jun 01 SP - 2474 EP - 2480 VL - 120 IS - 11 SN - 0020-7136, 0020-7136 KW - Gold Colloid KW - 0 KW - Tumor Necrosis Factor-alpha KW - Index Medicus KW - Animals KW - Mice, Inbred C57BL KW - Mice KW - Cell Line, Tumor KW - Female KW - Neoplasms, Experimental -- blood supply KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Capillary Permeability -- drug effects KW - Neoplasms, Experimental -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70346552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Direct+evidence+for+rapid+and+selective+induction+of+tumor+neovascular+permeability+by+tumor+necrosis+factor+and+a+novel+derivative%2C+colloidal+gold+bound+tumor+necrosis+factor.&rft.au=Farma%2C+Jeffrey+M%3BPuhlmann%2C+Markus%3BSoriano%2C+Perry+A%3BCox%2C+Derrick%3BPaciotti%2C+Giulio+F%3BTamarkin%2C+Lawrence%3BAlexander%2C+H+Richard&rft.aulast=Farma&rft.aufirst=Jeffrey&rft.date=2007-06-01&rft.volume=120&rft.issue=11&rft.spage=2474&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-18 N1 - Date created - 2007-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Aggregation of adverse behaviors and its affecting factors among young military conscripts in Taiwan. AN - 70323831; 17107751 AB - The authors studied the prevalence of the aggregation in common lifestyle habits, namely, cigarette smoking, alcohol drinking, and betel-nut chewing and the demographic correlates of individual aggregation in these lifestyle behaviors among young military conscripts in Taiwan. Cross-sectional screening was conducted among conscripts in southern and eastern sections of Taiwan from Aug. 1st to Dec. 31st 2001. Totally, 3913 conscripts who had more than 1 month of service were included in this multistage sampling study. Information on smoking, drinking, and betel-nut chewing habits were ascertained as part of a self-administered questionnaire completed by examinees at the service unit. Aggregation in lifestyle habits was studied by comparing the observed and expected proportions (O/E ratio) with their 95% confidence intervals (CI) for zero, one, two, and three simultaneously occurring lifestyle habits. The study results showed a significant clustering of lifestyle habits studied; the number of subjects was greater than expected in groups with two (for cigarette smoking and betel-nut chewing, O/E ratio=1.17, 95%CI=1.06-1.28), and three (O/E ratio=5.63, 95%CI=5.06-6.20) lifestyle habits. Determinants for this clustering of lifestyle habits included lower educational levels and residential area in southern and eastern sections of Taiwan. There was a significant individual aggregation in lifestyle habits including cigarette smoking, alcohol drinking, and betel-nut chewing in the health survey among young military conscripts. In addition, young military conscripts with low educational levels and residential area in southern and eastern sections of Taiwan had an apparent tendency toward the aggregation in these lifestyle habits. JF - Addictive behaviors AU - Wu, Der-Min AU - Chu, Nain-Feng AU - Lin, Yaoh-Shiang AU - Lai, Hsiang-Ru AD - School of Public Health, Tri-Service General Hospital, National Defense Medical Center, Nei-Hu, Taipei, Taiwan, ROC. dwu@mdmctsgh.edu.tw Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 1302 EP - 1308 VL - 32 IS - 6 SN - 0306-4603, 0306-4603 KW - Index Medicus KW - Cross-Sectional Studies KW - Educational Status KW - Areca KW - Humans KW - Taiwan -- epidemiology KW - Adult KW - Surveys and Questionnaires KW - Mastication KW - Male KW - Comorbidity KW - Catchment Area (Health) KW - Life Style KW - Military Personnel -- psychology KW - Military Personnel -- statistics & numerical data KW - Alcohol Drinking -- epidemiology KW - Mass Screening -- methods KW - Smoking -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70323831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Aggregation+of+adverse+behaviors+and+its+affecting+factors+among+young+military+conscripts+in+Taiwan.&rft.au=Wu%2C+Der-Min%3BChu%2C+Nain-Feng%3BLin%2C+Yaoh-Shiang%3BLai%2C+Hsiang-Ru&rft.aulast=Wu&rft.aufirst=Der-Min&rft.date=2007-06-01&rft.volume=32&rft.issue=6&rft.spage=1302&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-17 N1 - Date created - 2007-04-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Overdose problem associated with treatment planning software for high energy photons in response of Panama's accident. AN - 70142389; 19034341 AB - The purpose of this study was to quantify dose distribution errors by comparing actual dose measurements with the calculated values done by the software. To evaluate the outcome of radiation overexposure related to Panama's accident and in response to ensure that the treatment planning systems (T.P.S.) are being operated in accordance with the appropriate quality assurance programme, we studied the central axis and pripheral depth dose data using complex field shaped with blocks to quantify dose distribution errors. Multidata T.P.S. software versions 2.35 and 2.40 and Helax T.P.S. software version 5.1 B were assesed. The calculated data of the software treatment planning systems were verified by comparing these data with the actual dose measurements for open and blocked high energy photon fields (Co-60, 6MV & 18MV photons). Close calculated and measured results were obtained for the 2-D (Multidata) and 3-D treatment planning (TMS Helax). These results were correct within 1 to 2% for open fields and 0.5 to 2.5% for peripheral blocked fields. Discrepancies between calculated and measured data ranged between 13. to 36% along the central axis of complex blocked fields when normalisation point was selected at the Dmax, when the normalisation point was selected near or under the blocks, the variation between the calculated and the measured data was up to 500% difference. The present results emphasize the importance of the proper selection of the normalization point in the radiation field, as this facilitates detection of aberrant dose distribution (over exposure or under exposure). JF - Journal of the Egyptian National Cancer Institute AU - Attalla, Ehab M AU - Lotayef, Mohamed M AU - Khalil, Ehab M AU - El-Hosiny, Hesham A AU - Nazmy, Mohamed S AD - The Department of Radiotherapy and Nuclear Medicine, National Cancer Institute, Cairo University. ehab_marouf@yahoo.com Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 114 EP - 120 VL - 19 IS - 2 SN - 1110-0362, 1110-0362 KW - Index Medicus KW - Computer Simulation KW - Humans KW - Models, Biological KW - Quality Assurance, Health Care KW - Drug Overdose -- epidemiology KW - Radiotherapy Planning, Computer-Assisted -- instrumentation KW - Drug Overdose -- prevention & control KW - Radiotherapy Dosage -- standards KW - Urinary Bladder Neoplasms -- radiotherapy KW - Radioactive Hazard Release -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70142389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Egyptian+National+Cancer+Institute&rft.atitle=Overdose+problem+associated+with+treatment+planning+software+for+high+energy+photons+in+response+of+Panama%27s+accident.&rft.au=Attalla%2C+Ehab+M%3BLotayef%2C+Mohamed+M%3BKhalil%2C+Ehab+M%3BEl-Hosiny%2C+Hesham+A%3BNazmy%2C+Mohamed+S&rft.aulast=Attalla&rft.aufirst=Ehab&rft.date=2007-06-01&rft.volume=19&rft.issue=2&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Egyptian+National+Cancer+Institute&rft.issn=11100362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-05 N1 - Date created - 2008-11-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Shielding for scattered radiation to the testis during pelvic radiotherapy: is it worth? AN - 70138551; 19034343 AB - To assess the value of external shielding of the testis during pelvic radiotherapy. Nineteen patients, receiving radiotherapy to the pelvis with the lower border of the field at the obturator foramen, were randomly selected. A 5 half value layer cerrobent shield was positioned at the inferior border of the field. The dose to the testis was measured with and without the shield. Observations were made regarding the reflex cremaster contraction and phantom measurements were done at different distances from the perineum. The mean radiation dose to the testis for patients receiving treatment with no shield was 7.4cGy (1.3) and it was 5.7cGy (-/+2.5) for patients with external shield, this difference was statistically significant by the paired t test p<0.0001. This accounted for a 22 % decrease in the dose received by the testis. The position of the testis with the contraction of the cremaster muscle and the dartos fascia after manipulation of the testis during diodes placement changed up to 3.5 cm (mean 1.5). Phantom measurements showed 37% increase in the dose with 2cm change in the position of the testis to the pelvic direction. External shield at the inferior border of the pelvic field is a simple, easy reproducible, convenient shielding method. Clam-shell scrotal shield is not free of drawbacks, but still its benefits overweigh its harms and should be used with caution. JF - Journal of the Egyptian National Cancer Institute AU - Nazmy, Mohamed S AU - El-Taher, Maha M AU - Attalla, Ehab M AU - El-Hosiny, Hesham A AU - Lotayef, Mohamed M AD - The Department of Radiotherapy and Nuclear Medicine, National Cancer Institute, Cairo University. mnazmy@hotmail.com Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 127 EP - 132 VL - 19 IS - 2 SN - 1110-0362, 1110-0362 KW - Index Medicus KW - Phantoms, Imaging KW - Young Adult KW - Radiation Dosage KW - Scattering, Radiation KW - Humans KW - Aged KW - Scrotum -- radiation effects KW - Radiotherapy Dosage KW - Adult KW - Light KW - Middle Aged KW - Adolescent KW - Male KW - Testis -- radiation effects KW - Pelvic Neoplasms -- radiotherapy KW - Urinary Bladder Neoplasms -- radiotherapy KW - Radiation Protection -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70138551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Egyptian+National+Cancer+Institute&rft.atitle=Shielding+for+scattered+radiation+to+the+testis+during+pelvic+radiotherapy%3A+is+it+worth%3F&rft.au=Nazmy%2C+Mohamed+S%3BEl-Taher%2C+Maha+M%3BAttalla%2C+Ehab+M%3BEl-Hosiny%2C+Hesham+A%3BLotayef%2C+Mohamed+M&rft.aulast=Nazmy&rft.aufirst=Mohamed&rft.date=2007-06-01&rft.volume=19&rft.issue=2&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Egyptian+National+Cancer+Institute&rft.issn=11100362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-03-05 N1 - Date created - 2008-11-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Thalidomide analogues as anticancer drugs. AN - 70062765; 17975653 AB - The evolution of thalidomide as an effective treatment in several neoplasms has led to the search for compounds with increased antiangiogenic and anti-tumor effects, but decreased side-effects. The development of thalidomide analogues which retain the immunomodulatory effects of the parent compound, while minimizing the adverse reactions, brought about a class of agents termed the Immunomodulatory drugs (IMiDs). The IMiDs have undergone significant advances in recent years as evidenced by the recent FDA-approvals of one of the lead compounds, CC-5013 (lenalidomide), for 5q-myelodysplasia and for multiple myeloma (MM). Actimid (CC-4047), another IMiD lead compound, has also undergone clinical testing in MM. Apart from hematologic malignancies, these drugs are actively under investigation in solid tumor malignancies including prostate cancer, melanoma, and gliomas, in which potent activity has been demonstrated. The preclinical and clinical data relating to these analogues, as well as ENMD-0995, are reviewed herein. Encouraging results with these thalidomide analogues brought forth synthesis and screening of additional novel thalidomide analogues in the N-substituted and tetrafluorinated classes, including CPS11 and CPS49. This review also discusses the patents and preclinical findings for these agents. JF - Recent patents on anti-cancer drug discovery AU - Aragon-Ching, Jeanny B AU - Li, Haiqing AU - Gardner, Erin R AU - Figg, William D AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 167 EP - 174 VL - 2 IS - 2 KW - Antineoplastic Agents KW - 0 KW - Thalidomide KW - 4Z8R6ORS6L KW - Index Medicus KW - Molecular Structure KW - Animals KW - Humans KW - Clinical Trials as Topic KW - Patents as Topic KW - Drug Evaluation, Preclinical KW - Neoplasms -- drug therapy KW - Thalidomide -- adverse effects KW - Thalidomide -- therapeutic use KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- chemistry KW - Thalidomide -- analogs & derivatives KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70062765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Recent+patents+on+anti-cancer+drug+discovery&rft.atitle=Thalidomide+analogues+as+anticancer+drugs.&rft.au=Aragon-Ching%2C+Jeanny+B%3BLi%2C+Haiqing%3BGardner%2C+Erin+R%3BFigg%2C+William+D&rft.aulast=Aragon-Ching&rft.aufirst=Jeanny&rft.date=2007-06-01&rft.volume=2&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Recent+patents+on+anti-cancer+drug+discovery&rft.issn=2212-3970&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-29 N1 - Date created - 2008-01-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Exp Eye Res. 1997 Jun;64(6):971-8 [9301478] Bioorg Med Chem Lett. 1999 Jun 7;9(11):1625-30 [10386948] J Immunol. 1999 Jul 1;163(1):380-6 [10384139] J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Nov 25;811(2):135-41 [15522712] N Engl J Med. 1962 Dec 6;267:1184-92 contd [13934699] J Clin Oncol. 2005 Mar 20;23(9):2113; author reply 2113-4 [15774812] Leukemia. 2005 Jul;19(7):1253-61 [15858615] Semin Oncol. 2005 Aug;32(4 Suppl 5):S24-30 [16085014] Semin Oncol. 2005 Aug;32(4 Suppl 5):S31-5 [16085015] Blood. 2005 Dec 15;106(13):4050-3 [16118317] Leuk Res. 2006 Jul;30(7):849-58 [16494942] N Engl J Med. 2006 Oct 5;355(14):1456-65 [17021321] Blood. 2006 Nov 15;108(10):3458-64 [16840727] Blood. 2006 Dec 15;108(13):4126-35 [16940421] Ann Rheum Dis. 1999 Nov;58 Suppl 1:I107-13 [10577986] Br J Cancer. 2000 Feb;82(4):812-7 [10732751] J Clin Oncol. 2000 Jul;18(13):2593-602 [10893291] Blood. 2000 Nov 1;96(9):2943-50 [11049970] Blood. 2001 Jul 1;98(1):210-6 [11418482] Muscle Nerve. 2001 Aug;24(8):1050-7 [11439380] Clin Cancer Res. 2001 Jul;7(7):1888-93 [11448901] Blood. 2001 Sep 1;98(5):1614-5 [11520815] Eur J Med Chem. 2001 Jul-Aug;36(7-8):639-49 [11600233] Semin Oncol. 2001 Aug;28(4 Suppl 15):62-6 [11685731] Leukemia. 2001 Dec;15(12):1950-61 [11753617] Ther Drug Monit. 2002 Feb;24(1):104-10 [11805730] Cancer Res. 2002 Apr 15;62(8):2300-5 [11956087] J Immunol. 2002 May 15;168(10):4914-9 [11994441] Blood. 2002 Jun 1;99(11):4079-86 [12010810] Blood. 2002 Jun 15;99(12):4525-30 [12036884] Blood. 2002 Jun 1;99(11):4247-8 [12043695] Clin Cancer Res. 2002 Jun;8(6):1964-73 [12060642] Clin Exp Immunol. 2002 Oct;130(1):75-84 [12296856] Blood. 2002 Nov 1;100(9):3063-7 [12384400] Br J Cancer. 2002 Nov 4;87(10):1166-72 [12402158] Curr Opin Oncol. 2002 Nov;14(6):635-40 [12409654] J Clin Oncol. 2002 Nov 1;20(21):4319-23 [12409330] Am J Med. 2002 Nov;113(7):603-6 [12459408] Cancer Res. 2003 Feb 1;63(3):593-9 [12566301] Pharmacotherapy. 2003 Mar;23(3):315-8 [12627929] Cancer Biol Ther. 2002 Nov-Dec;1(6):669-73 [12642692] Cancer Res. 2003 Jun 15;63(12):3189-94 [12810647] Crit Rev Oncol Hematol. 2003 Jun 27;46 Suppl:S49-57 [12850527] Nat Rev Cancer. 2004 Apr;4(4):314-22 [15057291] Clin Prostate Cancer. 2004 Mar;2(4):241-3 [15072608] Leuk Res. 2004 Apr;28(4):325-32 [15109529] Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):4192-7 [15217957] J Clin Oncol. 2004 Jul 1;22(13):2532-9 [15226321] J Clin Oncol. 2004 Aug 15;22(16):3269-76 [15249589] Am J Med. 2004 Oct 1;117(7):508-15 [15464708] Ann Intern Med. 1975 Jan;82(1):96-100 [799908] J Pharmacol Exp Ther. 1977 Oct;203(1):240-51 [561842] Teratology. 1988 Sep;38(3):221-6 [3227491] Blood. 1989 May 15;73(7):1915-24 [2713508] N Engl J Med. 1992 Apr 16;326(16):1055-8 [1549151] Drug Saf. 1992 Mar-Apr;7(2):116-34 [1605898] J Pathol. 1992 Nov;168(3):257-62 [1281874] J Infect Dis. 1993 Aug;168(2):408-14 [8335978] Am J Pathol. 1993 Aug;143(2):401-9 [7688183] Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):4082-5 [7513432] Mol Pharmacol. 1995 Jun;47(6):1164-71 [7603456] Drug Saf. 1995 Jun;12(6):364-9 [8527011] J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Mar 1;11(3):247-57 [8603261] J Med Chem. 1996 Aug 2;39(16):3044-5 [8759624] Mol Med. 1996 Jul;2(4):506-15 [8827720] Chirality. 1996;8(5):390-6 [8900028] J Am Acad Dermatol. 1996 Dec;35(6):969-79 [8959957] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Programs to facilitate tuberculosis drug discovery: the tuberculosis antimicrobial acquisition and coordinating facility. AN - 68453363; 17970221 AB - There is a real need to discover new drugs that are active on drug-resistant tuberculosis (TB), and for drugs that will shorten the time of therapy. Large pharmaceutical companies have traditionally led the quest for discovering and developing new antiinfective agents but this is not the case when it comes to diseases like tuberculosis that primarily occur in resource restricted countries. Throughout the world many research groups are actively engaged in the scientific discovery of new TB drugs. Unfortunately, most research laboratories do not have the necessary safety facilities or resources for all facets of TB drug discovery. The Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF) was established in order to make comprehensive testing services available at no cost to research laboratories with an interest in discovering new TB drugs. The TAACF is a consortium of contracts managed and funded by the National Institute of Allergy and Infectious Diseases (National Institutes of Health, Bethesda, MD) as a resource to support preclinical drug discovery and development. The core of the TAACF is the Southern Research Institute, Birmingham, AL, which supports compound acquisition, storage, medicinal chemistry, and high throughput assays. Other collaborating groups provide biological data on antimycobacterial activity and cytotoxicity, preliminary in vivo toxicity, oral bioavailability and efficacy in animal models, specialty testing (such as activity against non-replicating persistent bacteria), and assistance in technology transfer for developing comprehensive promotional packages and facilitating partnerships with pharmaceutical companies for drug development. The TAACF program and recent progress that has been publicly disclosed by suppliers is reviewed. There are many aspects promising of the program that will not be discussed due to confidentially. JF - Infectious disorders drug targets AU - Goldman, R C AU - Laughon, B E AU - Reynolds, R C AU - Secrist, J A AU - Maddry, J A AU - Guié, M-A AU - Poffenberger, A C AU - Kwong, C A AU - Ananthan, S AD - Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, Division of AIDS, Therapeutics Research Program, Complications and Coinfections Research Branch, Bethesda, Maryland 20892, USA. rgoldman@niaid.nih.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 92 EP - 104 VL - 7 IS - 2 SN - 1871-5265, 1871-5265 KW - Antitubercular Agents KW - 0 KW - Index Medicus KW - Animals KW - Tuberculosis -- drug therapy KW - Humans KW - Maximum Tolerated Dose KW - Biological Availability KW - Antitubercular Agents -- pharmacokinetics KW - Antitubercular Agents -- pharmacology KW - Drug Evaluation, Preclinical KW - Drug Design KW - Antitubercular Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68453363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infectious+disorders+drug+targets&rft.atitle=Programs+to+facilitate+tuberculosis+drug+discovery%3A+the+tuberculosis+antimicrobial+acquisition+and+coordinating+facility.&rft.au=Goldman%2C+R+C%3BLaughon%2C+B+E%3BReynolds%2C+R+C%3BSecrist%2C+J+A%3BMaddry%2C+J+A%3BGui%C3%A9%2C+M-A%3BPoffenberger%2C+A+C%3BKwong%2C+C+A%3BAnanthan%2C+S&rft.aulast=Goldman&rft.aufirst=R&rft.date=2007-06-01&rft.volume=7&rft.issue=2&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Infectious+disorders+drug+targets&rft.issn=18715265&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-20 N1 - Date created - 2007-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Advances at the Center for Cancer Research at the National Cancer Institute's Medical Oncology Branch. AN - 68136733; 17679918 JF - Clinical advances in hematology & oncology : H&O AU - Giaccone, Giuseppe AD - Center for Cancer Research, National Cancer Institute, Bethesda, MD 20852, USA. Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 443 EP - 4, 459 VL - 5 IS - 6 SN - 1543-0790, 1543-0790 KW - Angiogenesis Inhibitors KW - 0 KW - Cancer Vaccines KW - Immunotoxins KW - Topoisomerase I Inhibitors KW - Index Medicus KW - United States KW - Humans KW - Molecular Diagnostic Techniques KW - Hematopoietic Stem Cell Transplantation KW - Immunotoxins -- therapeutic use KW - Biomedical Research -- organization & administration KW - National Institutes of Health (U.S.) -- organization & administration KW - Neoplasms -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68136733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+advances+in+hematology+%26+oncology+%3A+H%26O&rft.atitle=Advances+at+the+Center+for+Cancer+Research+at+the+National+Cancer+Institute%27s+Medical+Oncology+Branch.&rft.au=Giaccone%2C+Giuseppe&rft.aulast=Giaccone&rft.aufirst=Giuseppe&rft.date=2007-06-01&rft.volume=5&rft.issue=6&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=Clinical+advances+in+hematology+%26+oncology+%3A+H%26O&rft.issn=15430790&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-28 N1 - Date created - 2007-08-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Psychiatric comorbidity and acculturation stress among Puerto Rican substance abusers. AN - 68126725; 17543714 AB - Although acculturation to the United States has been associated with an increase in substance, mood, and anxiety disorders in Latino populations, few studies have examined this concept relative to comorbidity among these syndromes. This study compares the prevalence and patterns of psychiatric comorbidity among Puerto Ricans with substance use disorders living in San Juan (Puerto Rico) to those who have migrated to New Haven (Connecticut) and examines the association between acculturation-related stress and the prevalence and patterns of psychiatric comorbidity among those who have migrated to New Haven. Lifetime levels of nearly all comorbid psychiatric disorders among respondents with substance use disorders were generally similar across sites. However, the risk of any co-occurring psychiatric disorder was higher among substance use disorder cases in New Haven who reported high levels of total acculturation stress and family-specific acculturation stress. These findings were generally accounted for by associations between affective disorders and high scores on these indicators of acculturation stress. The overall prevalence and patterns of psychiatric comorbidity are remarkably similar among Puerto Rican substance abusers whether they live in San Juan or have migrated to New Haven, thereby demonstrating robustness to differences in geographic location. Nevertheless, the degree of acculturation-related family stress is positively associated with co-occurring substance and psychiatric disorders, particularly affective disorders. Intervention in family strain related to the acculturation process may diminish the development of comorbid mental disorders and assist in implementing successful treatment of substance abuse. JF - American journal of preventive medicine AU - Conway, Kevin P AU - Swendsen, Joel D AU - Dierker, Lisa AU - Canino, Glorisa AU - Merikangas, Kathleen R AD - Division of Clinical Neuroscience and Behavioral Research, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-9589, USA. kconway@nida.nih.gov Y1 - 2007/06// PY - 2007 DA - June 2007 SP - S219 EP - S225 VL - 32 IS - 6 Suppl SN - 0749-3797, 0749-3797 KW - Index Medicus KW - Hispanic Americans KW - Puerto Rico -- ethnology KW - Humans KW - Connecticut -- epidemiology KW - Adult KW - Male KW - Female KW - Comorbidity KW - Acculturation KW - Mental Disorders -- epidemiology KW - Stress, Psychological -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68126725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+preventive+medicine&rft.atitle=Psychiatric+comorbidity+and+acculturation+stress+among+Puerto+Rican+substance+abusers.&rft.au=Conway%2C+Kevin+P%3BSwendsen%2C+Joel+D%3BDierker%2C+Lisa%3BCanino%2C+Glorisa%3BMerikangas%2C+Kathleen+R&rft.aulast=Conway&rft.aufirst=Kevin&rft.date=2007-06-01&rft.volume=32&rft.issue=6+Suppl&rft.spage=S219&rft.isbn=&rft.btitle=&rft.title=American+journal+of+preventive+medicine&rft.issn=07493797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-27 N1 - Date created - 2007-08-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Compr Psychiatry. 1988 May-Jun;29(3):309-22 [3378418] J Nerv Ment Dis. 1990 Mar;178(3):161-71 [2307968] Arch Gen Psychiatry. 1989 May;46(5):437-43 [2712662] Br J Addict. 1989 Jul;84(7):801-14 [2758153] J Nerv Ment Dis. 2000 Feb;188(2):90-100 [10695837] JAMA. 1990 Nov 21;264(19):2511-8 [2232018] Br J Psychiatry. 1991 Feb;158:177-82 [2012908] Am Psychol. 1991 Jun;46(6):585-97 [1952420] Br J Psychiatry. 1991 Nov;159:645-53, 658 [1756340] Acta Psiquiatr Psicol Am Lat. 1991 Sep;37(3):191-204 [1811404] Br J Psychiatry. 1992 Jun;160:815-8 [1617365] J Nerv Ment Dis. 1993 Mar;181(3):166-75 [8445375] J Psychiatr Res. 1994 Jan-Feb;28(1):57-84 [8064641] Am Psychol. 1994 Aug;49(8):701-8 [8092613] Am J Orthopsychiatry. 1996 Jan;66(1):17-31 [8720638] J Subst Abuse. 1995;7(4):481-97 [8838629] Soc Psychiatry Psychiatr Epidemiol. 1998 Feb;33(2):80-8 [9503991] Compr Psychiatry. 1998 Jul-Aug;39(4):176-84 [9675501] Arch Gen Psychiatry. 1998 Sep;55(9):771-8 [9736002] Psychiatr Serv. 1999 Oct;50(10):1309-15 [10506299] Arch Gen Psychiatry. 2004 Dec;61(12):1226-33 [15583114] J Clin Psychiatry. 2005 Jun;66(6):677-85 [15960559] J Clin Psychiatry. 2006 Jan;67(1):56-65 [16426089] J Clin Psychiatry. 2006 Feb;67(2):247-57 [16566620] Clin Psychol Rev. 2000 Mar;20(2):173-89 [10721496] Am J Public Health. 2000 Apr;90(4):608-14 [10754977] J Nerv Ment Dis. 2000 Nov;188(11):728-35 [11093374] Arch Gen Psychiatry. 2002 Apr;59(4):375-80 [11926938] Subst Use Misuse. 2002 Mar;37(4):429-56 [12064428] Am J Psychiatry. 2003 May;160(5):890-5 [12727692] Am J Public Health. 2003 Jul;93(7):1057-64 [12835179] J Nerv Ment Dis. 2004 Aug;192(8):532-41 [15387155] J Health Soc Behav. 1987 Mar;28(1):89-102 [3571910] Arch Gen Psychiatry. 1987 Jun;44(6):505-13 [3579499] Arch Gen Psychiatry. 1987 Aug;44(8):720-6 [3498455] Arch Gen Psychiatry. 1987 Dec;44(12):1064-8 [3689094] J Stud Alcohol. 1988 May;49(3):219-24 [3374135] Arch Gen Psychiatry. 1988 Dec;45(12):1069-77 [2848472] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dual-Processing Explains Base-Rate Neglect, But Which Dual-Process Theory and How? AN - 61682678; 200804665 AB - We agree that current evolutionary accounts of base-rate neglect are unparsimonious, but we dispute the authors' account of the effect in terms of parallel associative and rule-based processes. We also question their assumption that cueing of nested set relations facilitates performance due to recruitment of explicit reasoning processes. In our account, such reasoning is always involved, but usually unsuccessful.Base-rate respect: From ecological rationality to dual processes Aron K. Barbey & Steven A. Sloman Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892-1440. Adapted from the source document. JF - Behavioral and Brain Sciences AU - Evans, Jonathan St. B. T. AU - Elqayam, Shira AD - Centre for Thinking and Language, School of Psychology, University of Plymouth, Plymouth PL4 8AA, United Kingdom jevans@plymouth.ac.uksupa2 selqayam@dmu.ac.uk barbeya@ninds.nih.gov Steven_Sloman@brown.edu Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 261 EP - 262 PB - Cambridge University Press, New York NY VL - 30 IS - 3 SN - 0140-525X, 0140-525X KW - Genetics KW - Theories KW - article KW - 0207: sociology: history and theory; theories, ideas, & systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61682678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+and+Brain+Sciences&rft.atitle=Dual-Processing+Explains+Base-Rate+Neglect%2C+But+Which+Dual-Process+Theory+and+How%3F&rft.au=Evans%2C+Jonathan+St.+B.+T.%3BElqayam%2C+Shira&rft.aulast=Evans&rft.aufirst=Jonathan+St.+B.&rft.date=2007-06-01&rft.volume=30&rft.issue=3&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Behavioral+and+Brain+Sciences&rft.issn=0140525X&rft_id=info:doi/10.1017%2FS0140525X07001720 LA - English DB - Sociological Abstracts N1 - Date revised - 2008-03-04 N1 - Last updated - 2016-09-28 N1 - CODEN - BBSCDH N1 - SubjectsTermNotLitGenreText - Theories; Genetics DO - http://dx.doi.org/10.1017/S0140525X07001720 ER - TY - JOUR T1 - A Statistical Taxonomy and Another 'Chance' for Natural Frequencies AN - 61682648; 200804641 AB - The conclusions of Barbey & Sloman (B&S) crucially depend on evidence for different representations of statistical information. Unfortunately, a muddled distinction made among these representations calls into question the authors' conclusions. We clarify some notions of statistical representations which are often confused in the literature. These clarifications, combined with new empirical evidence, do not support a dual-process model of judgment.Base-rate respect: From ecological rationality to dual processes Aron K. Barbey & Steven A. Sloman Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892-1440. Adapted from the source document. JF - Behavioral and Brain Sciences AU - Barton, Adrien AU - Mousavi, Shabnam AU - Stevens, Jeffrey R AD - Center for Adaptive Behavior and Cognition, Max Planck Institute for Human Development, 14195 Berlin, Germany barton@mpib-berlin.mpg.de mousavi@mpib-berlin.mpg.de sxm70@psu.edu jstevens@mpib-berlin.mpg.de barbeya@ninds.nih.gov Steven_Sloman@brown.edu Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 255 EP - 256 PB - Cambridge University Press, New York NY VL - 30 IS - 3 SN - 0140-525X, 0140-525X KW - Information KW - Statistics KW - Mathematical Models KW - Social Science Research KW - article KW - 0207: sociology: history and theory; theories, ideas, & systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61682648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+and+Brain+Sciences&rft.atitle=A+Statistical+Taxonomy+and+Another+%27Chance%27+for+Natural+Frequencies&rft.au=Barton%2C+Adrien%3BMousavi%2C+Shabnam%3BStevens%2C+Jeffrey+R&rft.aulast=Barton&rft.aufirst=Adrien&rft.date=2007-06-01&rft.volume=30&rft.issue=3&rft.spage=255&rft.isbn=&rft.btitle=&rft.title=Behavioral+and+Brain+Sciences&rft.issn=0140525X&rft_id=info:doi/10.1017%2FS0140525X07001665 LA - English DB - Sociological Abstracts N1 - Date revised - 2008-03-04 N1 - Last updated - 2016-09-28 N1 - CODEN - BBSCDH N1 - SubjectsTermNotLitGenreText - Mathematical Models; Social Science Research; Statistics; Information DO - http://dx.doi.org/10.1017/S0140525X07001665 ER - TY - JOUR T1 - Base-Rate Respect: from Statistical Formats to Cognitive Structures AN - 61680434; 200804640 AB - The commentaries indicate a general agreement that one source of reduction of base-rate neglect involves making structural relations among relevant sets transparent. There is much less agreement, however, that this entails dual systems of reasoning. In this response, we make the case for our perspective on dual systems. We compare and contrast our view to the natural frequency hypothesis as formulated in the commentaries.Base-rate respect: From ecological rationality to dual processes Aron K. Barbey & Steven A. Sloman Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892-1440. Adapted from the source document. JF - Behavioral and Brain Sciences AU - Barbey, Aron K AU - Sloman, Steven A AD - Department of Psychology, Emory University, Atlanta, GA 30322 barbeya@nih.ninds.govsupa2 Steven_Sloman@brown.edu barbeya@ninds.nih.gov Steven_Sloman@brown.edu Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 287 EP - 292 PB - Cambridge University Press, New York NY VL - 30 IS - 3 SN - 0140-525X, 0140-525X KW - Statistics KW - Cognition KW - article KW - 0207: sociology: history and theory; theories, ideas, & systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61680434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+and+Brain+Sciences&rft.atitle=Base-Rate+Respect%3A+from+Statistical+Formats+to+Cognitive+Structures&rft.au=Barbey%2C+Aron+K%3BSloman%2C+Steven+A&rft.aulast=Barbey&rft.aufirst=Aron&rft.date=2007-06-01&rft.volume=30&rft.issue=3&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Behavioral+and+Brain+Sciences&rft.issn=0140525X&rft_id=info:doi/10.1017%2FS0140525X07001963 LA - English DB - Sociological Abstracts N1 - Date revised - 2008-03-04 N1 - Last updated - 2016-09-28 N1 - CODEN - BBSCDH N1 - SubjectsTermNotLitGenreText - Statistics; Cognition DO - http://dx.doi.org/10.1017/S0140525X07001963 ER - TY - JOUR T1 - How to Elicit Sound Probabilistic Reasoning: Beyond Word Problems AN - 61654499; 200804670 AB - Barbey & Sloman (B&S) conclude that natural frequency theorists have raised a fundamental question: What are the conditions that compel individuals to reason extensionally? We argue that word problems asking for a numerical judgment used by these theorists cannot answer this question. We present evidence that nonverbal tasks can elicit correct intuitions of posterior probability even in preschoolers.Base-rate respect: From ecological rationality to dual processes Aron K. Barbey & Steven A. Sloman Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892-1440. Adapted from the source document. JF - Behavioral and Brain Sciences AU - Girotto, Vittorio AU - Gonzalez, Michel AD - Department of Arts and Industrial Design, University IUAV of Venice, Convento delle Terese, 30123 Venice, Italy vittorio.girotto@iuav.it michel.gonzalez@up.univ-mrs.fr barbeya@ninds.nih.gov Steven_Sloman@brown.edu Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 268 PB - Cambridge University Press, New York NY VL - 30 IS - 3 SN - 0140-525X, 0140-525X KW - Judgment KW - Theories KW - Neurology KW - article KW - 0207: sociology: history and theory; theories, ideas, & systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61654499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+and+Brain+Sciences&rft.atitle=How+to+Elicit+Sound+Probabilistic+Reasoning%3A+Beyond+Word+Problems&rft.au=Girotto%2C+Vittorio%3BGonzalez%2C+Michel&rft.aulast=Girotto&rft.aufirst=Vittorio&rft.date=2007-06-01&rft.volume=30&rft.issue=3&rft.spage=268&rft.isbn=&rft.btitle=&rft.title=Behavioral+and+Brain+Sciences&rft.issn=0140525X&rft_id=info:doi/10.1017%2FS0140525X07001768 LA - English DB - Sociological Abstracts N1 - Date revised - 2008-03-04 N1 - Last updated - 2016-09-28 N1 - CODEN - BBSCDH N1 - SubjectsTermNotLitGenreText - Theories; Judgment; Neurology DO - http://dx.doi.org/10.1017/S0140525X07001768 ER - TY - JOUR T1 - Base-Rate Respect: from Ecological Rationality to Dual Processes AN - 61650759; 200804639 AB - The phenomenon of base-rate neglect has elicited much debate. One arena of debate concerns how people make judgments under conditions of uncertainty. Another more controversial arena concerns human rationality. In this target article, we attempt to unpack the perspectives in the literature on both kinds of issues and evaluate their ability to explain existing data and their conceptual coherence. From this evaluation we conclude that the best account of the data should be framed in terms of a dual-process model of judgment, which attributes base-rate neglect to associative judgment strategies that fail to adequately represent the set structure of the problem. Base- rate neglect is reduced when problems are presented in a format that affords accurate representation in terms of nested sets of individuals. Adapted from the source document. JF - Behavioral and Brain Sciences AU - Barbey, Aron K AU - Sloman, Steven A AD - Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892-1440 barbeya@ninds.nih.govsupa2 Steven_Sloman@brown.edu Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 241 EP - 254 PB - Cambridge University Press, New York NY VL - 30 IS - 3 SN - 0140-525X, 0140-525X KW - Judgment KW - Certainty KW - Social Relations KW - Rationality KW - article KW - 0207: sociology: history and theory; theories, ideas, & systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61650759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+and+Brain+Sciences&rft.atitle=Base-Rate+Respect%3A+from+Ecological+Rationality+to+Dual+Processes&rft.au=Barbey%2C+Aron+K%3BSloman%2C+Steven+A&rft.aulast=Barbey&rft.aufirst=Aron&rft.date=2007-06-01&rft.volume=30&rft.issue=3&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Behavioral+and+Brain+Sciences&rft.issn=0140525X&rft_id=info:doi/10.1017%2FS0140525X07001653 LA - English DB - Sociological Abstracts N1 - Date revised - 2008-03-04 N1 - Last updated - 2016-09-28 N1 - CODEN - BBSCDH N1 - SubjectsTermNotLitGenreText - Certainty; Judgment; Rationality; Social Relations DO - http://dx.doi.org/10.1017/S0140525X07001653 ER - TY - JOUR T1 - The Effect of Base Rate, Careful Analysis, and the Distinction Between Decisions from Experience and from Description AN - 61647049; 200804726 AB - Barbey & Sloman (B&S) attribute base-rate neglect to associative processes (like retrieval from memory) that fail to adequately represent the set structure of the problem. This commentary notes that associative responses can also lead to base-rate overweighting. We suggest that the difference between the two patterns is related to the distinction between decisions from experience and decisions from description.Base-rate respect: From ecological rationality to dual processes Aron K. Barbey & Steven A. Sloman Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892-1440. Adapted from the source document. JF - Behavioral and Brain Sciences AU - Schurr, Amos AU - Erev, Ido AD - School of Education, The Hebrew University of Jerusalem, Jerusalem, 91905, Israelsupa2 /supFaculty of Industrial Engineering, Technion - Israel Institute of Technology, Haifa, 32000, Israel. samos@mscc.huji.ac.il erev@tx.technion.ac.il barbeya@ninds.nih.gov Steven_Sloman@brown.edu Y1 - 2007/06// PY - 2007 DA - June 2007 SP - 281 PB - Cambridge University Press, New York NY VL - 30 IS - 3 SN - 0140-525X, 0140-525X KW - Research KW - Rationality KW - article KW - 0207: sociology: history and theory; theories, ideas, & systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61647049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+and+Brain+Sciences&rft.atitle=The+Effect+of+Base+Rate%2C+Careful+Analysis%2C+and+the+Distinction+Between+Decisions+from+Experience+and+from+Description&rft.au=Schurr%2C+Amos%3BErev%2C+Ido&rft.aulast=Schurr&rft.aufirst=Amos&rft.date=2007-06-01&rft.volume=30&rft.issue=3&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=Behavioral+and+Brain+Sciences&rft.issn=0140525X&rft_id=info:doi/10.1017%2FS0140525X07001896 LA - English DB - Sociological Abstracts N1 - Date revised - 2008-03-04 N1 - Last updated - 2016-09-28 N1 - CODEN - BBSCDH N1 - SubjectsTermNotLitGenreText - Rationality; Research DO - http://dx.doi.org/10.1017/S0140525X07001896 ER - TY - JOUR T1 - Understanding animate agents: distinct roles for the social network and mirror system AN - 36813760; 3509997 AB - How people understand the actions of animate agents has been vigorously debated. This debate has centered on two hypotheses focused on anatomically distinct neural substrates: The mirror-system hypothesis proposes that the understanding of others is achieved via action simulation, and the social-network hypothesis proposes that such understanding is achieved via the integration of critical biological properties (e.g., faces, affect). In this study, we assessed the areas of the brain that were engaged when people interpreted and imagined moving shapes as animate or inanimate. Although observing and imagining the moving shapes engaged the mirror system, only activation of the social network was modulated by animacy. Reprinted by permission of Sage Publications JF - Psychological science AU - Wheatley, Thalia AU - Milleville, Shawn C AU - Martin, Alex AD - National Institute of Mental Health, Bethesda Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 469 EP - 474 VL - 18 IS - 6 SN - 0956-7976, 0956-7976 KW - Sociology KW - Social psychology KW - Social networks KW - Psychology KW - Social interaction KW - Agency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36813760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+science&rft.atitle=Understanding+animate+agents%3A+distinct+roles+for+the+social+network+and+mirror+system&rft.au=Wheatley%2C+Thalia%3BMilleville%2C+Shawn+C%3BMartin%2C+Alex&rft.aulast=Wheatley&rft.aufirst=Thalia&rft.date=2007-06-01&rft.volume=18&rft.issue=6&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Psychological+science&rft.issn=09567976&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 656; 11873 8634; 11901 10404; 11860 11907; 10404 ER - TY - JOUR T1 - National Heart, Lung, and Blood Institute Resources and Programs for Gene Therapy in Heart, Lung, and Blood Diseases AN - 21292241; 7461291 JF - Circulation Research AU - Skarlatos, Sonia I AD - Division of Cardiovascular Diseases, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1667 EP - 1669 PB - Lippincott Williams & Wilkins, Inc, 530 Walnut Street Philadelphia PA 19106-3621 USA, [URL:http://www.lww.com/] VL - 100 IS - 12 SN - 0009-7330, 0009-7330 KW - Biotechnology and Bioengineering Abstracts KW - Blood KW - Gene therapy KW - Lung diseases KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21292241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulation+Research&rft.atitle=National+Heart%2C+Lung%2C+and+Blood+Institute+Resources+and+Programs+for+Gene+Therapy+in+Heart%2C+Lung%2C+and+Blood+Diseases&rft.au=Skarlatos%2C+Sonia+I&rft.aulast=Skarlatos&rft.aufirst=Sonia&rft.date=2007-06-01&rft.volume=100&rft.issue=12&rft.spage=1667&rft.isbn=&rft.btitle=&rft.title=Circulation+Research&rft.issn=00097330&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Blood; Gene therapy; Lung diseases ER - TY - JOUR T1 - A Posterior Tale AN - 21074560; 11132942 AB - A vignette is presented that naively suggests that the posterior distribution of a parameter may not always contain everything that is needed for inference about that parameter. The resolution of this apparent paradox is discussed as well as its relation to real-life problems involving data monitoring of clinical trials. JF - Biometrical Journal AU - Korn, Edward L AU - Freidlin, Boris AD - Biometric Research Branch, EPN-8129, National Cancer Institute, Bethesda, MD 20892-7434, USA, korne@ctep.nci.nih.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 346 EP - 350 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 49 IS - 3 SN - 0323-3847, 0323-3847 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Clinical trials KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21074560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=A+Posterior+Tale&rft.au=Korn%2C+Edward+L%3BFreidlin%2C+Boris&rft.aulast=Korn&rft.aufirst=Edward&rft.date=2007-06-01&rft.volume=49&rft.issue=3&rft.spage=346&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=03233847&rft_id=info:doi/10.1002%2Fbimj.200510264 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Data processing; Clinical trials DO - http://dx.doi.org/10.1002/bimj.200510264 ER - TY - JOUR T1 - Haemophilus influenzae Type a Infection and Its Prevention AN - 20988901; 7418032 JF - Infection and Immunity AU - Jin, Zhigang AU - Romero-Steiner, Sandra AU - Carlone, George M AU - Robbins, John B AU - Schneerson, Rachel AD - National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892. Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333 Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 2650 EP - 2654 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 6 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Haemophilus influenzae KW - Infection KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20988901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Haemophilus+influenzae+Type+a+Infection+and+Its+Prevention&rft.au=Jin%2C+Zhigang%3BRomero-Steiner%2C+Sandra%3BCarlone%2C+George+M%3BRobbins%2C+John+B%3BSchneerson%2C+Rachel&rft.aulast=Jin&rft.aufirst=Zhigang&rft.date=2007-06-01&rft.volume=75&rft.issue=6&rft.spage=2650&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Infection; Haemophilus influenzae ER - TY - JOUR T1 - Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamine AN - 20960365; 11055076 AB - Mutations in the key enzyme of sialic acid biosynthesis, uridine diphospho-N-acetylglucosamine 2-epimerase/N-acetylmannosamine (ManNAc) kinase (GNE/MNK), result in hereditary inclusion body myopathy (HIBM), an adult-onset, progressive neuromuscular disorder. We created knockin mice harboring the M712T Gne/Mnk mutation. Homozygous mutant (Gne super(M712T/M712T)) mice did not survive beyond P3. At P2, significantly decreased Gne-epimerase activity was observed in Gne super(M712T/M712T) muscle, but no myopathic features were apparent. Rather, homozygous mutant mice had glomerular hematuria, proteinuria, and podocytopathy. Renal findings included segmental splitting of the glomerular basement membrane, effacement of podocyte foot processes, and reduced sialylation of the major podocyte sialoprotein, podocalyxin. ManNAc administration yielded survival beyond P3 in 43% of the Gne super(M712T/M712T) pups. Survivors exhibited improved renal histology, increased sialylation of podocalyxin, and increased Gne/Mnk protein expression and Gne-epimerase activities. These findings establish this Gne super(M712T/M712T) knockin mouse as what we believe to be the first genetic model of podocyte injury and segmental glomerular basement membrane splitting due to hyposialylation. The results also support evaluation of ManNAc as a treatment not only for HIBM but also for renal disorders involving proteinuria and hematuria due to podocytopathy and/or segmental splitting of the glomerular basement membrane. JF - Journal of Clinical Investigation AU - Galeano, B AU - Klootwijk, R AU - Manoli, I AU - Sun AU - Ciccone, C AU - Darvish, D AU - Starost, M F AU - Zerfas, P M AU - Hoffmann, V J AU - Hoogstraten-Miller, S AU - Krasnewich, D M AU - Gahl, WA AU - Huizing, M AD - Medical Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1585 EP - 1594 VL - 117 IS - 6 SN - 0021-9738, 0021-9738 KW - Toxicology Abstracts; Genetics Abstracts KW - Injuries KW - Muscles KW - Enzymes KW - Survival KW - Splitting KW - Proteinuria KW - Hematuria KW - Basement membranes KW - MNK protein KW - Foot KW - sialoproteins KW - Kidney KW - Inclusion bodies KW - Uridine KW - Mutation KW - neuromuscular system KW - Sialic acids KW - Myopathy KW - G 07870:Mammals KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20960365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Investigation&rft.atitle=Mutation+in+the+key+enzyme+of+sialic+acid+biosynthesis+causes+severe+glomerular+proteinuria+and+is+rescued+by+N-acetylmannosamine&rft.au=Galeano%2C+B%3BKlootwijk%2C+R%3BManoli%2C+I%3BSun%3BCiccone%2C+C%3BDarvish%2C+D%3BStarost%2C+M+F%3BZerfas%2C+P+M%3BHoffmann%2C+V+J%3BHoogstraten-Miller%2C+S%3BKrasnewich%2C+D+M%3BGahl%2C+WA%3BHuizing%2C+M&rft.aulast=Galeano&rft.aufirst=B&rft.date=2007-06-01&rft.volume=117&rft.issue=6&rft.spage=1585&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Investigation&rft.issn=00219738&rft_id=info:doi/10.1172%2FJCI30954 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Injuries; Muscles; Survival; Enzymes; Splitting; Proteinuria; Basement membranes; Hematuria; MNK protein; Kidney; sialoproteins; Foot; Inclusion bodies; Uridine; Mutation; Sialic acids; neuromuscular system; Myopathy DO - http://dx.doi.org/10.1172/JCI30954 ER - TY - JOUR T1 - Functional MRI impulse response for BOLD and CBV contrast in rat somatosensory cortex AN - 20857288; 8368486 AB - The contrast mechanism in functional MRI (fMRI) results from several vascular processes with different time scales, thus establishing a finite temporal resolution to fMRI experiments. In this work we measured the blood oxygen level-dependent (BOLD) and iron-oxide-derived cerebral blood volume (CBV) impulse response (IR) in a rat model of somatosensory brain activation at 11.7T. A binary m-sequence probe method was used to obtain high-sensitivity single-pixel estimates of the IR, from which two parameters-the full width at half maximum (FWHM) and the time to peak (TTP)-were determined as indices of the temporal resolution of the hemodynamic response (HDR). The results (N = 11) show that the CBV IR (N = 5, subset) is significantly narrower (FWHM = 1.37 - 0.11 s), and peaks earlier (TTP = 1.65 - 0.15 s) than the BOLD IR (N = 11, FWHM = 1.92 - 0.22 s and TTP = 2.18 - 0.14 s, respectively). These findings indicate that neurovascular control mechanisms have a temporal resolution better than 1.5 s FWHM, and point to a substantial contribution to BOLD of the dispersive transit of oxygenated hemoglobin across the rat vasculature, bringing important implications for the ultimately attainable temporal resolution of fMRI. Magn Reson Med 57:1110-1118, 2007. JF - Magnetic Resonance in Medicine AU - Silva, Afonso C AU - Koretsky, Alan P AU - Duyn, Jeff H AD - Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA, silvaa@ninds.nih.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1110 EP - 1118 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 57 IS - 6 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Brain mapping KW - Functional magnetic resonance imaging KW - Probes KW - Hemodynamics KW - Hemoglobin KW - N.M.R. KW - Cerebral blood flow KW - Cortex (somatosensory) KW - Vascular system KW - W 30910:Imaging KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20857288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Functional+MRI+impulse+response+for+BOLD+and+CBV+contrast+in+rat+somatosensory+cortex&rft.au=Silva%2C+Afonso+C%3BKoretsky%2C+Alan+P%3BDuyn%2C+Jeff+H&rft.aulast=Silva&rft.aufirst=Afonso&rft.date=2007-06-01&rft.volume=57&rft.issue=6&rft.spage=1110&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21246 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Functional magnetic resonance imaging; Hemodynamics; Hemoglobin; N.M.R.; Cortex (somatosensory); Cerebral blood flow; Brain mapping; Vascular system; Probes DO - http://dx.doi.org/10.1002/mrm.21246 ER - TY - JOUR T1 - Effects of formalin fixation and collagen cross-linking on T2 and magnetization transfer in bovine nasal cartilage AN - 20857285; 8368475 AB - Endogenous collagen cross-links influence cartilage biomechanical properties and resistance to degradation. Formalin fixation modifies collagen residues and forms new cross-links in a dose-dependent manner. We tested the hypothesis that magnetization transfer (MT) effects and T2 depend on collagen cross-linking in cartilage. These parameters were measured in bovine nasal cartilage (BNC) prior to fixation, after 9 weeks of immersion in formalin solutions ranging in concentration from 0% to 10%, and after NaBH3CN reduction and washing. T2 decreased by 59.4% - 1.1% upon fixation in 10% formalin, and was 32.2% - 5.2% shorter than initial values after washing. The apparent MT rate increased 25.9% - 3.7% and 52.8% - 7.1% over baseline under these conditions. Biochemical assays showed no significant differences in water, proteoglycan, natural cross-link, or collagen content between the 0% and 10% formalin-treated samples, while amino acid analysis demonstrated losses in (hydroxy)lysine and tyrosine, and new peaks consistent with methylene cross-links in fixed samples only. We conclude that formalin fixation of cartilage results in significant decreases in T2 and increases in MT parameters that persist after removal of unreacted formaldehyde. The collagen cross-links thus created are associated with large changes in MT and T2, indicating that interpretation of T2 and MT values in terms of cartilage macromolecular content must be made with caution. JF - Magnetic Resonance in Medicine AU - Fishbein, Kenneth W AU - Gluzband, Yehezkiel A AU - Kaku, Masaru AU - Ambia-Sobhan, Hasina AU - Shapses, Sue A AU - Yamauchi, Mitsuo AU - Spencer, Richard G AD - National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA, spencerri@grc.nia.nih.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1000 EP - 1011 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 57 IS - 6 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Macromolecules KW - Amino acids KW - Cartilage KW - Tyrosine KW - Formaldehyde KW - Collagen KW - Proteoglycans KW - Cross-linking KW - Immersion KW - N.M.R. KW - Mechanical properties KW - W 30910:Imaging KW - T 2030:Cartilage and Cartilage Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20857285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Effects+of+formalin+fixation+and+collagen+cross-linking+on+T2+and+magnetization+transfer+in+bovine+nasal+cartilage&rft.au=Fishbein%2C+Kenneth+W%3BGluzband%2C+Yehezkiel+A%3BKaku%2C+Masaru%3BAmbia-Sobhan%2C+Hasina%3BShapses%2C+Sue+A%3BYamauchi%2C+Mitsuo%3BSpencer%2C+Richard+G&rft.aulast=Fishbein&rft.aufirst=Kenneth&rft.date=2007-06-01&rft.volume=57&rft.issue=6&rft.spage=1000&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21216 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cross-linking; Collagen; Cartilage; Formaldehyde; Amino acids; Proteoglycans; N.M.R.; Mechanical properties; Immersion; Macromolecules; Tyrosine DO - http://dx.doi.org/10.1002/mrm.21216 ER - TY - JOUR T1 - ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence AN - 20798440; 7464858 AB - Inactivation of the p53 pathway represents the most common molecular defect of human cancer. But in the setting of melanoma, a highly aggressive and invariably fatal malignancy in its advanced disseminated form, mutation/deletion of p53 is relatively rare, whereas its positive regulator ARF is often lost. Here, we show that genetic deficiency in Arf but not p53 facilitates rapid development of melanoma in a genetically engineered mouse model. This difference is accounted for, at least in part, by the unanticipated observation that, unlike fibroblasts, senescence control in melanocytes is strongly regulated by Arf and not p53. Moreover, oncogenic NRAS collaborates with deficiency in Arf, but not p53, to fully transform melanocytes. Our data demonstrate that ARF and p53, although linked in a common pathway, suppress tumorigenesis through distinct, lineage-dependent mechanisms and suggest that ARF helps restrict melanoma progression by executing the oncogene-induced senescence program in benign nevi. Thus, therapeutics designed to restore wild-type p53 function may be insufficient to counter melanoma and other malignancies in which ARF holds p53-independent tumor suppressor activity. JF - Proceedings of the National Academy of Sciences, USA AU - Ha, Linan AU - Ichikawa, Takeshi AU - Anver, Miriam AU - Dickins, Ross AU - Lowe, Scott AU - Sharpless, Norman E AU - Krimpenfort, Paul AU - DePinho, Ronald A AU - Bennett, Dorothy C AU - Sviderskaya, Elena V AU - Merlino, Glenn AD - Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, MD 20892-4264 Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 10968 EP - 10973 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 26 SN - 0027-8424, 0027-8424 KW - Biotechnology and Bioengineering Abstracts; Oncogenes & Growth Factors Abstracts KW - Tumor suppressor genes KW - Data processing KW - Tumorigenesis KW - Animal models KW - Melanocytes KW - Recovery of function KW - Cancer KW - Fibroblasts KW - Melanoma KW - p53 protein KW - Gene deletion KW - Malignancy KW - Genetic engineering KW - Senescence KW - Mutation KW - Benign KW - W 30925:Genetic Engineering KW - B 26670:Tumor Suppressors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20798440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=ARF+functions+as+a+melanoma+tumor+suppressor+by+inducing+p53-independent+senescence&rft.au=Ha%2C+Linan%3BIchikawa%2C+Takeshi%3BAnver%2C+Miriam%3BDickins%2C+Ross%3BLowe%2C+Scott%3BSharpless%2C+Norman+E%3BKrimpenfort%2C+Paul%3BDePinho%2C+Ronald+A%3BBennett%2C+Dorothy+C%3BSviderskaya%2C+Elena+V%3BMerlino%2C+Glenn&rft.aulast=Ha&rft.aufirst=Linan&rft.date=2007-06-01&rft.volume=104&rft.issue=26&rft.spage=10968&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Tumor suppressor genes; Data processing; Tumorigenesis; Animal models; Melanocytes; Recovery of function; Cancer; p53 protein; Melanoma; Fibroblasts; Malignancy; Gene deletion; Genetic engineering; Senescence; Mutation; Benign ER - TY - JOUR T1 - Challenges in Replicating Interventions AN - 20762796; 8115771 AB - Purpose To describe and reflect on an effort to document, through a set of 6 interventions, the process of adapting effective youth risk behavior interventions for new settings, and to provide insights into how this might best be accomplished. Methods Six studies were funded by the NIH, starting in 1999. The studies were funded in response to a Request for Applications (RFA) to replicate HIV prevention interventions for youth. Researchers were to select an HIV risk reduction intervention program shown to be effective in one adolescent population and to replicate it in a new community or different adolescent population. This was to be done while systematically documenting those processes and aspects of the intervention hypothesized to be critical to the development of community-based, culturally sensitive programs. The replication was to assess the variations necessary to gain cooperation, implement a locally feasible and meaningful intervention, and evaluate the outcomes in the new setting. The rationale for this initiative and description of the goals and approaches to adaptation of the funded researchers are described. Results Issues relevant to all interventions are discussed, in addition to those unique to replication. The processes and the consequences of the adaptations are then discussed. The further challenges in taking a successful intervention 'to scale' are not discussed. Conclusions Replications of effective interventions face all of the challenges of implementation design, plus additional challenges of balancing fidelity to the original intervention and sensitivity to the needs of new populations. JF - Journal of Adolescent Health AU - Bell, Stephanie G AU - Newcomer, Susan F AU - Bachrach, Christine AU - Borawski, Elaine AU - Jemmott III, John B AU - Morrison, Diane AU - Stanton, Bonita AU - Tortolero, Susan AU - Zimmerman, Richard AD - Agency for Healthcare Research and Quality, Rockville, Maryland, newcomes@mail.nih.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 514 EP - 520 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 40 IS - 6 SN - 1054-139X, 1054-139X KW - Risk Abstracts; Health & Safety Science Abstracts KW - community involvement KW - risk reduction KW - Human immunodeficiency virus KW - intervention KW - prevention KW - Adolescents KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20762796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Adolescent+Health&rft.atitle=Challenges+in+Replicating+Interventions&rft.au=Bell%2C+Stephanie+G%3BNewcomer%2C+Susan+F%3BBachrach%2C+Christine%3BBorawski%2C+Elaine%3BJemmott+III%2C+John+B%3BMorrison%2C+Diane%3BStanton%2C+Bonita%3BTortolero%2C+Susan%3BZimmerman%2C+Richard&rft.aulast=Bell&rft.aufirst=Stephanie&rft.date=2007-06-01&rft.volume=40&rft.issue=6&rft.spage=514&rft.isbn=&rft.btitle=&rft.title=Journal+of+Adolescent+Health&rft.issn=1054139X&rft_id=info:doi/10.1016%2Fj.jadohealth.2006.09.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus; intervention; Adolescents; risk reduction; prevention; community involvement DO - http://dx.doi.org/10.1016/j.jadohealth.2006.09.005 ER - TY - JOUR T1 - Linear chromosomes in bacteria: no straight edge advantage? AN - 20755600; 7897765 JF - Environmental Microbiology AU - Galperin, Michael Y AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA., galperin@ncbi.nlm.nih.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1357 EP - 1362 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 9 IS - 6 SN - 1462-2912, 1462-2912 KW - Microbiology Abstracts B: Bacteriology KW - Chromosomes KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20755600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Microbiology&rft.atitle=Linear+chromosomes+in+bacteria%3A+no+straight+edge+advantage%3F&rft.au=Galperin%2C+Michael+Y&rft.aulast=Galperin&rft.aufirst=Michael&rft.date=2007-06-01&rft.volume=9&rft.issue=6&rft.spage=1357&rft.isbn=&rft.btitle=&rft.title=Environmental+Microbiology&rft.issn=14622912&rft_id=info:doi/10.1111%2Fj.1462-2920.2007.01328.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Chromosomes DO - http://dx.doi.org/10.1111/j.1462-2920.2007.01328.x ER - TY - JOUR T1 - Supplemental and Dietary Vitamin E Intakes and Risk of Prostate Cancer in a Large Prospective Study AN - 20730280; 7461203 AB - Supplemental vitamin E ( alpha -tocopherol) has been linked to lower prostate cancer incidence in one randomized trial and several, although not all, observational studies. The evidence regarding dietary intake of individual vitamin E isoforms and prostate cancer is limited and inconclusive, however. We prospectively examined the relations of supplemental vitamin E and dietary intakes of alpha -, {szligbeta}-, gamma -, and delta - tocopherols to prostate cancer risk among 295,344 men, ages 50 to 71 years and cancer-free at enrollment in 1995 to 1996, in the NIH-AARP Diet and Health Study. At baseline, participants completed a questionnaire that captured information on diet, supplement use, and other factors. Proportional hazards models were used to estimate relative risks (RR) and 95% confidence intervals (95% CI) of prostate cancer. During 5 years of follow-up, 10,241 incident prostate cancers were identified. Supplemental vitamin E intake was not related to prostate cancer risk (for >0-99, 100-199, 200-399, 400-799, and greater than or equal to 800 IU/d versus never use: RR, 0.97, 0.89, 1.03, 0.99, and 0.97 (95% CI, 0.87-1.07) respectively; P sub(trend) = 0.90). However, dietary gamma -tocopherol, the most commonly consumed form of vitamin E in the United States, was significantly inversely related to the risk of advanced prostate cancer (for highest versus lowest quintile: RR, 0.68; 95% CI, 0.56-0.84; P sub(trend) = 0.001). These results suggest that supplemental vitamin E does not protect against prostate cancer, but that increased consumption of gamma -tocopherol from foods is associated with a reduced risk of clinically relevant disease. The potential benefit of gamma -tocopherol for prostate cancer prevention deserves further attention. (Cancer Epidemiol Biomarkers Prev 2007; 16(6):1128-35) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Wright, Margaret E AU - Weinstein, Stephanie J AU - Lawson, Karla A AU - Albanes, Demetrius AU - Subar, Amy F AU - Dixon, LBeth AU - Mouw, Traci AU - Schatzkin, Arthur AU - Leitzmann, Michael F AD - Divisions of Cancer Epidemiology and Genetics, Cancer Prevention, and Cancer Control and Population Sciences, National Cancer Institute, NIH, DHHS, Bethesda, Maryland and Department of Nutrition, Food Studies, and Public Health, New York University, New York, New York Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1128 EP - 1135 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 6 SN - 1055-9965, 1055-9965 KW - Risk Abstracts KW - Diets KW - Bioindicators KW - risk reduction KW - USA KW - Age KW - vitamins KW - prevention KW - prostate cancer KW - Ingestion KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20730280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Supplemental+and+Dietary+Vitamin+E+Intakes+and+Risk+of+Prostate+Cancer+in+a+Large+Prospective+Study&rft.au=Wright%2C+Margaret+E%3BWeinstein%2C+Stephanie+J%3BLawson%2C+Karla+A%3BAlbanes%2C+Demetrius%3BSubar%2C+Amy+F%3BDixon%2C+LBeth%3BMouw%2C+Traci%3BSchatzkin%2C+Arthur%3BLeitzmann%2C+Michael+F&rft.aulast=Wright&rft.aufirst=Margaret&rft.date=2007-06-01&rft.volume=16&rft.issue=6&rft.spage=1128&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Bioindicators; Diets; risk reduction; Age; vitamins; prevention; Ingestion; prostate cancer; Cancer; USA ER - TY - JOUR T1 - History of diabetes mellitus and subsequent prostate cancer risk in the NIH-AARP Diet and Health Study AN - 20728346; 7465839 AB - Objective: A history of diabetes has been hypothesized to decrease prostate cancer risk, but studies have not always considered confounding or effect modification by dietary or lifestyle factors. Methods: We examined the association between diabetes history and subsequent prostate cancer risk in 328,316 men enrolled in the NIH-AARP Diet and Health Study. Participants were ages 50-71 years and without a prostate cancer diagnosis at baseline in 1995. A prior history of physician-diagnosed diabetes was assessed using a self-administered mailed questionnaire. Cases of prostate cancer were ascertained by matching the cohort to state cancer registries. Multivariable relative risks (RR) and 95% confidence intervals (CI) of prostate cancer were estimated using Cox regression. Results: During 5 years and 1,432,676 person-years of follow-up, 11,193 prostate cancer cases were ascertained. The age-adjusted and multivariable RRs of prostate cancer comparing men with diabetes to those without diabetes were 0.69 (95% CI = 0.64, 0.74) and 0.71 (95% CI = 0.66, 0.76), respectively, indicating no important confounding. The inverse association between diabetes and prostate cancer was particularly strong among men in the highest category of routine physical activity at work or home (RR = 0.41; 95% CI = 0.23, 0.74; p value for test of interaction = 0.03). Findings were similar for organ-confined and advanced prostate cancer. Conclusion: Results from this large prospective study suggest that a history of diabetes is associated with a decreased risk of prostate cancer. The relationship strengthened with high levels of routine physical activity. Because increased physical activity is associated with lower circulating levels of insulin and testosterone, our findings support a role of hypoinsulinemia and low androgenicity linking diabetes to decreased prostate cancer risk. JF - Cancer Causes & Control AU - Calton, Brook A AU - Chang, Shih Chen AU - Wright, Margaret E AU - Kipnis, Victor AU - Lawson, Karla AU - Thompson, Frances E AU - Subar, Amy F AU - Mouw, Traci AU - Campbell, David S AU - Hurwitz, Paul AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Leitzmann, Michael F AD - National Institutes of Health, Department of Health and Human Services, 6120 Executive Blvd., EPS-MSC 7232, Bethesda, MD, 20892, USA, brook.calton@ucsf.edu Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 493 EP - 503 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 18 IS - 5 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - Diets KW - Historical account KW - diabetes mellitus KW - Age KW - insulin KW - prostate cancer KW - physical activity KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20728346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=History+of+diabetes+mellitus+and+subsequent+prostate+cancer+risk+in+the+NIH-AARP+Diet+and+Health+Study&rft.au=Calton%2C+Brook+A%3BChang%2C+Shih+Chen%3BWright%2C+Margaret+E%3BKipnis%2C+Victor%3BLawson%2C+Karla%3BThompson%2C+Frances+E%3BSubar%2C+Amy+F%3BMouw%2C+Traci%3BCampbell%2C+David+S%3BHurwitz%2C+Paul%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BLeitzmann%2C+Michael+F&rft.aulast=Calton&rft.aufirst=Brook&rft.date=2007-06-01&rft.volume=18&rft.issue=5&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-007-0126-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diets; Historical account; Age; diabetes mellitus; insulin; physical activity; prostate cancer; Cancer DO - http://dx.doi.org/10.1007/s10552-007-0126-y ER - TY - JOUR T1 - Risk of Germ Cell Tumors among Men with HIV/Acquired Immunodeficiency Syndrome AN - 20725523; 7461224 AB - Background: Men with HIV/acquired immunodeficiency syndrome (AIDS) are reported to be at increased risk for germ cell tumors (GCT), particularly testicular seminoma. We investigated correlates of this association to improve understanding of GCTs. Methods: Testicular and extratesticular seminoma and nonseminoma cases were found by linking population-based cancer and HIV/AIDS registry data for 268,950 men who developed AIDS in 1980 to 2003. Standardized incidence ratios (SIR) with 95% confidence intervals (95% CI) were used to compare these cases with the number of cases expected in the demographically matched population. Results: Overall, seminoma risk (161 cases: SIR, 1.9; 95% CI, 1.6-2.2) was increased significantly with HIV/AIDS, whereas nonseminoma risk was not (56 cases: SIR, 1.3; 95% CI, 0.96-1.7). Extratesticular GCT risk also was increased (11 cases: SIR, 2.1; 95% CI, 1.1-3.7). Seminoma risk was elevated regardless of age, race, or HIV/AIDS transmission group. It was highest for disseminated disease (SIR, 4.7; 95% CI, 2.9-7.2) and within 9 months of AIDS onset (SIR, 7.6; 95% CI, 5.8-9.6), but it was unrelated to CD4 count and duration of HIV/AIDS. The excess risk of seminoma declined in more recent calendar periods, and it was no longer elevated (SIR, 1.4; 95% CI, 0.9-1.9) in the highly active antiretroviral treatment era. Conclusions: Men with HIV/AIDS had an increased risk of seminoma, but this risk may have attenuated with improving anti-HIV/AIDS treatments. Although detection bias could partly explain the excess of this cancer, various lines of evidence support a causal relationship. Possible mechanisms underlying this association include impaired tumor immunosurveillance or AIDS-related testicular atrophy. (Cancer Epidemiol Biomarkers Prev 2007; 16(6):1266-9) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Goedert, James J AU - Purdue, Mark P AU - McNeel, Timothy S AU - McGlynn, Katherine A AU - Engels, Eric A AD - Viral Epidemiology Branch, Occupational and Environmental Epidemiology Branch, and Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland and Information Management Services, Inc., Silver Spring, Maryland Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1266 EP - 1269 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 6 SN - 1055-9965, 1055-9965 KW - Virology & AIDS Abstracts; Risk Abstracts; Immunology Abstracts KW - Risk assessment KW - Testes KW - Age KW - Acquired immune deficiency syndrome KW - Immunodeficiency KW - ISE, Pacific, New Zealand Island Terr., Niue I., Alofi, Sir KW - tumors KW - Disease transmission KW - CD4 antigen KW - Immunosurveillance KW - antiretroviral agents KW - prevention KW - Bioindicators KW - Germ cells KW - males KW - Tumors KW - biomarkers KW - Cancer KW - Human immunodeficiency virus KW - Standards KW - Atrophy KW - seminoma KW - V 22360:AIDS and HIV KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20725523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Risk+of+Germ+Cell+Tumors+among+Men+with+HIV%2FAcquired+Immunodeficiency+Syndrome&rft.au=Goedert%2C+James+J%3BPurdue%2C+Mark+P%3BMcNeel%2C+Timothy+S%3BMcGlynn%2C+Katherine+A%3BEngels%2C+Eric+A&rft.aulast=Goedert&rft.aufirst=James&rft.date=2007-06-01&rft.volume=16&rft.issue=6&rft.spage=1266&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Testes; Risk assessment; Acquired immune deficiency syndrome; Immunodeficiency; Germ cells; Tumors; biomarkers; Cancer; Disease transmission; CD4 antigen; Immunosurveillance; Atrophy; seminoma; Bioindicators; Age; antiretroviral agents; prevention; males; Standards; tumors; Human immunodeficiency virus; ISE, Pacific, New Zealand Island Terr., Niue I., Alofi, Sir ER - TY - JOUR T1 - Nurse Migration from a Source Country Perspective: Philippine Country Case Study AN - 20707450; 7900882 AB - ObjectivesTo describe nurse migration patterns in the Philippines and their benefits and costs. Principal FindingsThe Philippines is a job-scarce environment and, even for those with jobs in the health care sector, poor working conditions often motivate nurses to seek employment overseas. The country has also become dependent on labor migration to ease the tight domestic labor market. National opinion has generally focused on the improved quality of life for individual migrants and their families, and on the benefits of remittances to the nation. However, a shortage of highly skilled nurses and the massive retraining of physicians to become nurses elsewhere has created severe problems for the Filipino health system, including the closure of many hospitals. As a result, policy makers are debating the need for new policies to manage migration such that benefits are also returned to the educational institutions and hospitals that are producing the emigrant nurses. Conclusions and RecommendationsThere is new interest in the Philippines in identifying ways to mitigate the costs to the health system of nurse emigration. Many of the policy options being debated involve collaboration with those countries recruiting Filipino nurses. Bilateral agreements are essential for managing migration in such a way that both sending and receiving countries derive benefit from the exchange. JF - Health Services Research AU - Lorenzo, Fely Marilyn E AU - Galvez-Tan, Jaime AU - Icamina, Kriselle AU - Javier, Lara AD - Institute of Health Policy and Development Studies, National Institutes of Health, University of the Philippines, Manila, 625 Pedro Gil St., 1000 Ermita, Manila, Philippines Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1406 EP - 1418 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 42 IS - 3p2 SN - 0017-9124, 0017-9124 KW - Sustainability Science Abstracts KW - Nursing migration KW - Philippines KW - health human resources development KW - case studies KW - Health care KW - migrants KW - bilateral agreements KW - quality of life KW - nursing KW - emigration KW - Medical personnel KW - working conditions KW - Hospitals KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20707450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Nurse+Migration+from+a+Source+Country+Perspective%3A+Philippine+Country+Case+Study&rft.au=Lorenzo%2C+Fely+Marilyn+E%3BGalvez-Tan%2C+Jaime%3BIcamina%2C+Kriselle%3BJavier%2C+Lara&rft.aulast=Lorenzo&rft.aufirst=Fely+Marilyn&rft.date=2007-06-01&rft.volume=42&rft.issue=3p2&rft.spage=1406&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2Fj.1475-6773.2007.00716.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - case studies; migrants; Health care; bilateral agreements; quality of life; emigration; nursing; working conditions; Medical personnel; Hospitals; Philippines DO - http://dx.doi.org/10.1111/j.1475-6773.2007.00716.x ER - TY - JOUR T1 - A prospective study of dietary calcium, dairy products and prostate cancer risk (Finland) AN - 20651591; 8079392 AB - High dietary intakes of calcium and dairy products have been hypothesized to enhance prostate cancer risk, but available prospective data regarding these associations are inconsistent. We examined dietary intakes of calcium and dairy products in relation to risk of prostate cancer in the Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention Study, a cohort of 29,133 male smokers aged 50-69 years at study entry. Dietary intake was assessed at baseline using a validated 276-item food use questionnaire. Cox proportional hazards regression was used to adjust for known or suspected risk factors for prostate cancer. During 17 years of follow-up, we ascertained 1,267 incident cases of prostate cancer. High versus low intake of dietary calcium was associated with a marked increase in prostate cancer risk. The multivariate relative risk (RR) of prostate cancer for 2,000 mg/day compared to <1,000 mg/day of calcium intake was 1.63 (95% confidence interval (CI), 1.27-2.10; p trend < 0.0001). Total dairy intake was also positively associated with risk of prostate cancer. The multivariate RR of prostate cancer comparing extreme quintiles of intake was 1.26 (95% CI, 1.04-1.51; p trend = 0.03). However, no association with total dairy intake remained after we adjusted for calcium (p trend = 0.17). Findings were similar by stage and grade of prostate cancer. The results from this large prospective study suggest that intake of calcium or some related component contained in dairy foods is associated with increased prostate cancer risk. JF - International Journal of Cancer AU - Mitrou, Panagiota N AU - Albanes, Demetrius AU - Weinstein, Stephanie J AU - Pietinen, Pirjo AU - Taylor, Philip R AU - Virtamo, Jarmo AU - Leitzmann, Michael F AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, USA, mitroup@mail.nih.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 2466 EP - 2473 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 120 IS - 11 SN - 0020-7136, 0020-7136 KW - Risk Abstracts; Calcium & Calcified Tissue Abstracts KW - Diets KW - Inventories KW - Calcium KW - Finland KW - Food KW - Dairy products KW - Ingestion KW - Dietary intake KW - Cancer KW - Prostate cancer KW - Calcium (dietary) KW - Risk factors KW - prevention KW - prostate cancer KW - R2 23060:Medical and environmental health KW - T 2020:Nutrition and Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20651591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=A+prospective+study+of+dietary+calcium%2C+dairy+products+and+prostate+cancer+risk+%28Finland%29&rft.au=Mitrou%2C+Panagiota+N%3BAlbanes%2C+Demetrius%3BWeinstein%2C+Stephanie+J%3BPietinen%2C+Pirjo%3BTaylor%2C+Philip+R%3BVirtamo%2C+Jarmo%3BLeitzmann%2C+Michael+F&rft.aulast=Mitrou&rft.aufirst=Panagiota&rft.date=2007-06-01&rft.volume=120&rft.issue=11&rft.spage=2466&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22553 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Inventories; Calcium (dietary); Prostate cancer; Risk factors; Food; Dairy products; Dietary intake; Diets; Calcium; prevention; Ingestion; prostate cancer; Cancer; Finland DO - http://dx.doi.org/10.1002/ijc.22553 ER - TY - JOUR T1 - Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer AN - 20651412; 8079390 AB - We have previously reported significant inverse associations between bladder cancer risk and dietary intake of vitamins B2, B6, B12, folate and protein in a hospital-based bladder cancer case-control study conducted in Spain (1,150 cases; 1,149 controls). Because these dietary factors are involved in the one-carbon metabolism pathway, we evaluated associations between bladder cancer risk and 33 single nucleotide polymorphisms (SNPs) in 8 genes (CBS, CTH, MTHFR, MTR, MTRR, SHMT1, SLC19A1 and TYMS) and interactions with dietary variables involved in this pathway. Two SNPs in the CTH gene were significantly associated with bladder cancer risk. OR (95% CI) for heterozygous and the homozygous variants compared to homozygous wild-type individuals were: 1.37 (1.04-1.80) IVS3-66 A > C and 1.22 (1.02-1.45) IVS10-430 C > T. Because the CTH gene is important for glutathione synthesis, we examined interactions with the GSTM1 gene, which codes for glutathione S-transferase u. Increased risk for individuals with the IVS10-430 CT or TT genotype was limited to those with the GSTM1 null genotype (p-interaction = 0.02). No other SNPs were associated with risk of bladder cancer. These findings suggest that common genetic variants in the one-carbon pathway may not play an important role in the etiology of bladder cancer. However, our results provide some evidence that variation in glutathione synthesis may contribute to risk, particularly among individuals who carry a deletion in GSTM1. Additional work is needed to comprehensively evaluate genomic variation in CTH and related genes in the trans-sulfuration pathway and bladder cancer risk. JF - International Journal of Cancer AU - Moore, Lee E AU - Malats, Nuria AU - Rothman, Nathaniel AU - Real, Francisco X AU - Kogevinas, Manolis AU - Karami, Sara AU - Garcia-Closas, Reina AU - Silverman, Debra AU - Chanock, Stephen AU - Welch, Robert AU - Tardon, Adonina AU - Serra, Consol AU - Carrato, Alfredo AU - Dosemeci, Mustafa AU - Garcia-Closas, Montserrat AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, moorele@mail.nih.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 2452 EP - 2458 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 120 IS - 11 SN - 0020-7136, 0020-7136 KW - Genetics Abstracts; Risk Abstracts KW - Spain KW - Gene polymorphism KW - Vitamin B6 KW - Methylenetetrahydrofolate reductase KW - Genotypes KW - Glutathione transferase KW - Dietary intake KW - GSTM1 protein KW - vitamins KW - genomics KW - Folic acid KW - GSTM1 gene KW - Diets KW - Etiology KW - Urinary bladder KW - Ingestion KW - Cancer KW - Vitamin B12 KW - Single-nucleotide polymorphism KW - Proteins KW - Metabolism KW - G 07880:Human Genetics KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20651412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Polymorphisms+in+one-carbon+metabolism+and+trans-sulfuration+pathway+genes+and+susceptibility+to+bladder+cancer&rft.au=Moore%2C+Lee+E%3BMalats%2C+Nuria%3BRothman%2C+Nathaniel%3BReal%2C+Francisco+X%3BKogevinas%2C+Manolis%3BKarami%2C+Sara%3BGarcia-Closas%2C+Reina%3BSilverman%2C+Debra%3BChanock%2C+Stephen%3BWelch%2C+Robert%3BTardon%2C+Adonina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BDosemeci%2C+Mustafa%3BGarcia-Closas%2C+Montserrat&rft.aulast=Moore&rft.aufirst=Lee&rft.date=2007-06-01&rft.volume=120&rft.issue=11&rft.spage=2452&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22565 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Etiology; Urinary bladder; Gene polymorphism; Vitamin B6; Methylenetetrahydrofolate reductase; Glutathione transferase; Dietary intake; Cancer; GSTM1 protein; Vitamin B12; Single-nucleotide polymorphism; genomics; Folic acid; GSTM1 gene; Metabolism; Diets; vitamins; Proteins; Genotypes; Ingestion; Spain DO - http://dx.doi.org/10.1002/ijc.22565 ER - TY - JOUR T1 - Sphingosine-1-phosphate initiates rapid retraction of pseudopodia by localized RhoA activation AN - 20585224; 7638071 AB - Lysophosphatidic acid (LPA) stimulates sphingosine-1-phosphate (S1P)-sensitive motility in NIH3T3 clone7 cells. S1P inhibits motility only when added to the bottom well of the Boyden chamber, suggesting that pseudopodia can respond to their microenvironment. In order to study and localize this effect, we utilized a Transwell insert system to isolate pseudopodia. LPA stimulates protrusion of pseudopodia that are enriched in RhoA compared to cell bodies. Removal of LPA results in slow retraction with loss of vinculin-rich adhesion complexes and prolonged activation of RhoA. However, RhoA, ROCK and mDia are not required for this process. In contrast, rapid retraction, induced by adding S1P to the bottom well, is associated with a quick spike of activated RhoA and coalescence of adhesion complexes that colocalize with the ends of stress fibers. S1P-induced retraction requires RhoA and ROCK but is only delayed by inhibition of mDia. These data indicate that pseudopodia sense and integrate signals initiated by localized bioactive lipids, affecting both cellular polarity and their own function in motility. JF - Cellular Signalling AU - Koh, Eunjin AU - Clair, Timothy AU - Hermansen, Raejean AU - Bandle, Russell W AU - Schiffmann, Elliott AU - Roberts, David D AU - Stracke, Mary L AD - Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Room 2A33, Bethesda, MD 20892-1500, United States, stracke@helix.nih.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1328 EP - 1338 PB - Elsevier Science, 660 White Plains Rd., Floor 2 Tarrytown NY 10591-5153 USA VL - 19 IS - 6 SN - 0898-6568, 0898-6568 KW - Microbiology Abstracts B: Bacteriology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20585224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+Signalling&rft.atitle=Sphingosine-1-phosphate+initiates+rapid+retraction+of+pseudopodia+by+localized+RhoA+activation&rft.au=Koh%2C+Eunjin%3BClair%2C+Timothy%3BHermansen%2C+Raejean%3BBandle%2C+Russell+W%3BSchiffmann%2C+Elliott%3BRoberts%2C+David+D%3BStracke%2C+Mary+L&rft.aulast=Koh&rft.aufirst=Eunjin&rft.date=2007-06-01&rft.volume=19&rft.issue=6&rft.spage=1328&rft.isbn=&rft.btitle=&rft.title=Cellular+Signalling&rft.issn=08986568&rft_id=info:doi/10.1016%2Fj.cellsig.2007.01.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1016/j.cellsig.2007.01.005 ER - TY - JOUR T1 - Hospital admissions after paediatric trauma in a developing country: from falls to landmines AN - 20530296; 7501344 AB - Injury is a leading cause of childhood mortality in many developing and developed countries. Children are prone to injury throughout their development but the mechanism of injury differs with children's age (Krug et al. 2000). Of all injury-related deaths, it is estimated that a significant percentage (30-90) could be prevented in the pre-injury phase (Patterson 1999). JF - International Journal of Injury Control and Safety Promotion AU - El-Chemaly, SY AU - Akkary, G AU - Atoul, M AU - Musharrafieh, U AU - Taha-Assad, M AU - Tamim, H AD - Pulmonary-Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Rm# 5N314, Bethesda, MD 20892, USA, elchemalys@nhlbi.nih.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 131 EP - 134 VL - 14 IS - 2 SN - 1745-7300, 1745-7300 KW - Health & Safety Science Abstracts KW - Mortality KW - landmines KW - Injuries KW - Children KW - Developing countries KW - developed countries KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20530296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Injury+Control+and+Safety+Promotion&rft.atitle=Hospital+admissions+after+paediatric+trauma+in+a+developing+country%3A+from+falls+to+landmines&rft.au=El-Chemaly%2C+SY%3BAkkary%2C+G%3BAtoul%2C+M%3BMusharrafieh%2C+U%3BTaha-Assad%2C+M%3BTamim%2C+H&rft.aulast=El-Chemaly&rft.aufirst=SY&rft.date=2007-06-01&rft.volume=14&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Injury+Control+and+Safety+Promotion&rft.issn=17457300&rft_id=info:doi/10.1080%2F17457300701347227 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Mortality; landmines; Injuries; Children; Developing countries; developed countries DO - http://dx.doi.org/10.1080/17457300701347227 ER - TY - JOUR T1 - Scapulothoracic latent muscle reaction timing comparison between trained overhead throwers and untrained control subjects AN - 20518963; 8006569 AB - AimThis study evaluated select scapulothoracic muscles for training-induced latent muscle reaction timing (LMRT) changes. Comparisons were also made between the dominant and non-dominant upper extremities and between individual muscles. Materials and methodsFifteen male trained overhead throwers (college baseball pitchers) and 15 male untrained, age-matched control subjects participated in this study. Scapulothoracic muscle activation data were collected as subjects attempted to stop a variably timed, sudden glenohumeral joint internal rotation perturbation. ResultsTraining group differences were not evident for LMRT (P=0.56), however upper extremity dominance (P=0.003) and test muscle (P=0.0002) displayed significant differences. Dominant upper extremity upper trapezius muscle LMRT (72.5 plus or minus 26 ms) occurred later than non-dominant upper trapezius muscle LMRT (60.0 plus or minus 14.1 ms, P=0.001). Dominant upper extremity middle trapezius-rhomboid muscle LMRT (60.0 plus or minus 16.2 ms) occurred later than non-dominant middle trapezius-rhomboid muscle LMRT (50.2 plus or minus 12.6 ms, P=0.004). Dominant upper extremity upper trapezius muscle LMRT also occurred later than serratus anterior (55.7 plus or minus 16.0 ms, P=0.001) and middle trapezius-rhomboid LMRT (60.2 plus or minus 16 ms, P=0.003). Mean overall dominant upper extremity LMRT (62.7 plus or minus 19.4 ms) was delayed compared with mean overall non-dominant upper extremity LMRT (53.9 plus or minus 12.4 ms, P=0.003). Clinical consequencesAlthough training was not found to influence scapulothoracic LMRT, differences were observed between the dominant and non-dominant upper extremities. Consistent LMRT delays at the dominant upper extremity suggest possible neuromuscular timing differences to enable prolonged glenohumeral joint and scapulothoracic articulation acceleration before deceleration through eccentric muscle activation. Both trained and untrained overhead throwers displayed this response. Variable perturbation test velocities, and in-season testing of larger subject groups may be needed to better elucidate the more subtle differences associated with training. JF - Scandinavian Journal of Medicine & Science in Sports AU - Brindle, T J AU - Nyland, JA AU - Nitz, A J AU - Shapiro, R AD - Physical Disabilities Branch, National Institutes of Health, Bethesda, Maryland, USA, john.nyland@louisville.edu Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 252 EP - 259 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 17 IS - 3 SN - 0905-7188, 0905-7188 KW - Physical Education Index KW - shoulder KW - electromyography KW - muscle latency KW - biomechanics KW - Coordination KW - Intercollegiate sports KW - Velocity KW - Muscles (activity) KW - Acceleration KW - Arms KW - Baseball (pitching) KW - Joints KW - Dominance KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20518963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Medicine+%26+Science+in+Sports&rft.atitle=Scapulothoracic+latent+muscle+reaction+timing+comparison+between+trained+overhead+throwers+and+untrained+control+subjects&rft.au=Brindle%2C+T+J%3BNyland%2C+JA%3BNitz%2C+A+J%3BShapiro%2C+R&rft.aulast=Brindle&rft.aufirst=T&rft.date=2007-06-01&rft.volume=17&rft.issue=3&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Journal+of+Medicine+%26+Science+in+Sports&rft.issn=09057188&rft_id=info:doi/10.1111%2Fj.1600-0838.2006.00574.x LA - English DB - Physical Education Index N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Coordination; Intercollegiate sports; Velocity; Muscles (activity); Acceleration; Baseball (pitching); Arms; Dominance; Joints DO - http://dx.doi.org/10.1111/j.1600-0838.2006.00574.x ER - TY - JOUR T1 - Anthropometric measurement of Filipino manufacturing workers AN - 20473872; 7963896 AB - This study conducted anthropometric measurements among 1805 Filipino workers in 31 manufacturing industries. Anthropometric data were measured for standing, sitting, hand and foot dimensions, breadth and circumference of the various body parts, and grip strength. The workplace assessment survey was also done among respondents coming from the subject population to look into the common work and health problems that may be associated with ergonomic hazards at work. The data gathered can be applied for the ergonomic design of workstations, personal protective equipment, tools, interface systems, and furniture that aid in providing a safer, more productive, and user-friendly workplace for the Filipino working population. This is the first ever comprehensive anthropometric measurement of Filipino manufacturing workers in the country which is seen as a significant contribution to the Filipino labor force who are increasingly employed by both domestic and foreign multinationals. JF - International Journal of Industrial Ergonomics AU - Del Prado-Lu, Jinky Leilanie AD - National Institutes of Health, University of the Philippines Manila, Pedro Gil Street, Ermita, Manila, Philippines, jinky_lu@yahoo.com Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 497 EP - 503 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 37 IS - 6 SN - 0169-8141, 0169-8141 KW - Health & Safety Science Abstracts KW - Anthropometric measurements KW - Ergonomic design KW - Workplace assessment KW - Health and safety of workers KW - health problems KW - Manufacturing industry KW - Protective equipment KW - Ergonomics KW - working conditions KW - Occupational health KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20473872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Industrial+Ergonomics&rft.atitle=Anthropometric+measurement+of+Filipino+manufacturing+workers&rft.au=Del+Prado-Lu%2C+Jinky+Leilanie&rft.aulast=Del+Prado-Lu&rft.aufirst=Jinky&rft.date=2007-06-01&rft.volume=37&rft.issue=6&rft.spage=497&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Industrial+Ergonomics&rft.issn=01698141&rft_id=info:doi/10.1016%2Fj.ergon.2007.02.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - health problems; Manufacturing industry; Protective equipment; working conditions; Ergonomics; Occupational health DO - http://dx.doi.org/10.1016/j.ergon.2007.02.004 ER - TY - JOUR T1 - Pharmacological Actions of NGB 2904, a Selective Dopamine D sub(3) Receptor Antagonist, in Animal Models of Drug Addiction AN - 20468033; 7894445 AB - As a continuation of our work with SB-277011A, we have examined the effects of another highly elective dopamine (DA) D sub(3) receptor antagonist, N-(4-[lsqb]4-{2,3-dichlorophenyl}-1-piperazinyl[rsqb]buty l)-2-fluorenylcarboxamide (NGB 2904), in animal models of addiction. Our results indicate that by systemic administration, NGB 2904 inhibits intravenous cocaine self-administration maintained under a progressive-ratio (PR) reinforcement schedule, cocaine- or cocaine cue-induced reinstatement of cocaine-seeking behavior, and cocaine- or other addictive drug-enhanced brain stimulation reward (BSR). The action of NGB 2904 on PR cocaine self-administration was long-lasting (1-2 days) after a single injection, supporting its potential use in treatment of cocaine addiction. The effects of NGB 2904 in the BSR paradigm were dose-dependent for both NGB 2904 and cocaine; that is, only lower doses of NGB 2904 were effective, and their putative antiaddiction effect could be overcome by increasing the doses of cocaine or other addictive drugs. A dopamine-dependent mechanism is proposed to explain the effects of NGB 2904 on cocaine's actions in these animal models of drug addiction. The data reviewed in this paper suggest that NGB 2904 or other D sub(3)-selective antagonists may have potential in controlling motivation for drug-taking behavior or relapse to drug-seeking behavior, but may have a limited role in antagonizing the acute rewarding effects produced by cocaine or other addictive drugs. In addition, NGB 2904 may also act as a useful tool to study the role of D sub(3) receptors in drug addiction. JF - CNS Drug Reviews AU - Xi, Zheng-Xiong AU - Gardner, Eliot L AD - Neuropsychopharmacology Section, Chemical Biology Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA, zxi@intra.nida.nih.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 240 EP - 259 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 13 IS - 2 SN - 1080-563X, 1080-563X KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Antiaddiction drugs KW - Cocaine KW - D sub(3) antagonists KW - D sub(3) receptors KW - Dopamine KW - Drug addiction KW - NGB 2904 KW - SB-277011A KW - Central nervous system KW - Intravenous administration KW - Motivation KW - Dopamine D3 receptors KW - Brain KW - Animal models KW - Dopamine receptors KW - Drug abuse KW - Reinstatement KW - Reinforcement schedules KW - Reviews KW - Reinforcement KW - Drug self-administration KW - N3 11028:Neuropharmacology & toxicology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20468033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=CNS+Drug+Reviews&rft.atitle=Pharmacological+Actions+of+NGB+2904%2C+a+Selective+Dopamine+D+sub%283%29+Receptor+Antagonist%2C+in+Animal+Models+of+Drug+Addiction&rft.au=Xi%2C+Zheng-Xiong%3BGardner%2C+Eliot+L&rft.aulast=Xi&rft.aufirst=Zheng-Xiong&rft.date=2007-06-01&rft.volume=13&rft.issue=2&rft.spage=240&rft.isbn=&rft.btitle=&rft.title=CNS+Drug+Reviews&rft.issn=1080563X&rft_id=info:doi/10.1111%2Fj.1527-3458.2007.00013.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Central nervous system; Intravenous administration; Motivation; Dopamine D3 receptors; Animal models; Brain; Drug abuse; Dopamine receptors; Reinstatement; Reinforcement schedules; Reviews; Reinforcement; Drug addiction; Cocaine; Drug self-administration DO - http://dx.doi.org/10.1111/j.1527-3458.2007.00013.x ER - TY - JOUR T1 - The role of electrophoresis in disease biomarker discovery AN - 20399502; 7762768 AB - There has been increased activity in the last few years in the search for disease markers using fractionation of complex biological fluids combined with MS. While electrophoretic and chromatographic separations have played a major role in this endeavor, this manuscript is limited to a review of electrophoretic methods that have been established for disease biomarker discovery. These methods include 2-DE, difference gel electrophoresis (DIGE), and CE. We define what constitutes a biomarker, identify the steps required for establishing a biomarker, and describe the parameters needed in the design of an ideal diagnostic test. The application, advantages, and limitations of CE, DIGE, and 2-DE in meeting the goal of discovering novel biomarkers is discussed in detail, along with a few selected examples that illustrate the search for biomarkers for cancer and neurological diseases. JF - Electrophoresis AU - Issaq, Haleem J AU - Veenstra, Timothy D AD - Laboratory of Proteomics and Analytical Technologies, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD, USA, issaqh@mail.ncifcrf.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1980 EP - 1988 PB - Wiley-VCH, Postfach 101161 Weinheim 69451 Germany, [mailto:info@wiley-vch.de], [URL:http://www.wiley-vch.de/publish/en/] VL - 28 IS - 12 SN - 0173-0835, 0173-0835 KW - Biotechnology and Bioengineering Abstracts KW - Neurological diseases KW - Reviews KW - biomarkers KW - Cancer KW - Gel electrophoresis KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20399502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Electrophoresis&rft.atitle=The+role+of+electrophoresis+in+disease+biomarker+discovery&rft.au=Issaq%2C+Haleem+J%3BVeenstra%2C+Timothy+D&rft.aulast=Issaq&rft.aufirst=Haleem&rft.date=2007-06-01&rft.volume=28&rft.issue=12&rft.spage=1980&rft.isbn=&rft.btitle=&rft.title=Electrophoresis&rft.issn=01730835&rft_id=info:doi/10.1002%2Felps.200600834 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - biomarkers; Gel electrophoresis; Neurological diseases; Reviews; Cancer DO - http://dx.doi.org/10.1002/elps.200600834 ER - TY - JOUR T1 - Building systems to support development of drugs for biodefense AN - 20378747; 7761832 AB - The mission of the National Institute of Allergy and Infectious Diseases (NIAID), Division of Microbiology and Infectious Diseases (DMID), is to support research and product development that addresses the control and prevention of infectious diseases. This mission includes the development of new drugs to mitigate illness, suffering, and death resulting from an expanding spectrum of naturally emerging diseases and potential biological weapons. DMID has established new resources and additional infrastructure to address these challenges. In addition, DMID plans to transition to a new paradigm for research and development approaches based on three concepts that comprise a broad spectrum approach: products with broad spectrum activity; broad spectrum technology that can be applied to improve specific drug characteristics (e.g., shelf life); and broad spectrum platforms that will reduce the time and cost to manufacture and evaluate products. JF - Drug Development Research AU - Taylor, Katherine A AD - Office of Biodefense Research Affairs, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, kataylor@niaid.nih.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 183 EP - 185 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 68 IS - 4 SN - 0272-4391, 0272-4391 KW - Biotechnology and Bioengineering Abstracts KW - Hypersensitivity KW - Infectious diseases KW - Drug development KW - Shelf life KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20378747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Development+Research&rft.atitle=Building+systems+to+support+development+of+drugs+for+biodefense&rft.au=Taylor%2C+Katherine+A&rft.aulast=Taylor&rft.aufirst=Katherine&rft.date=2007-06-01&rft.volume=68&rft.issue=4&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Drug+Development+Research&rft.issn=02724391&rft_id=info:doi/10.1002%2Fddr.20180 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Hypersensitivity; Infectious diseases; Drug development; Shelf life DO - http://dx.doi.org/10.1002/ddr.20180 ER - TY - JOUR T1 - alpha 2u-Globulin Nephropathy and Renal Tumors in National Toxicology Program Studies AN - 20363858; 7692074 AB - Chemically induced renal neoplasms in male rats, developed coincident with alpha 2u-globulin nephropathy, are not considered predictive of risk to humans by the International Agency for Research on Cancer (IARC) and the U.S. Environmental Protection Agency. Criteria have been defined to establish the role of alpha 2u-globulin nephropathy in renal carcinogenesis, based on a proposed mode of action involving sustained tubular cell proliferation resulting from alpha 2u-induced nephropathy, with consequent development of neoplastic lesions. Recent NTP studies demonstrated inconsistencies with this proposed mechanism, including in some cases, far weaker kidney tumor responses than expected based on the extent of alpha 2u-globulin nephropathy. NTP studies with decalin, propylene glycol mono-t-butyl ether and Stoddard solvent IIC included extended evaluations of alpha 2u-related nephropathy, and were thus used in assessing the linkage between key events in 90-day studies with renal tumors in 2-year studies. This review revealed no or at best weak associations of tumor responses with renal alpha 2u-globulin concentrations, indices of cell turnover, or microscopic evidence of alpha 2u-associated nephropathy in prechronic studies. While tumor responses corresponded somewhat with a measure of cumulative alpha 2u-associated nephropathy (linear mineralization of the papilla) at the end of the 2-year studies, the severity of chronic nephropathy was generally in best agreement with the pattern of tumor response. These results suggest that while alpha 2u-globulin nephropathy may contribute to the renal tumor response, the critical component(s) of the nephropathy most closely associated with the development of tumors could not be clearly identified in this review. JF - Toxicologic Pathology AU - Doi, Adriana M AU - Hill, Georgette AU - Seely, John AU - Hailey, James R AU - Kissling, Grace AU - Bucher, John R AD - National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 533 EP - 540 PB - Taylor & Francis, 11 New Fetter Lane London EC4P 4EE UK, [mailto:info@tandf.co.uk], [URL:http://www.tandf.co.uk] VL - 35 IS - 4 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - Propylene glycol KW - Nephropathy KW - Carcinogenesis KW - Kidney KW - Solvents KW - Tumors KW - Ethers KW - Mineralization KW - Cell proliferation KW - Cancer KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20363858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=alpha+2u-Globulin+Nephropathy+and+Renal+Tumors+in+National+Toxicology+Program+Studies&rft.au=Doi%2C+Adriana+M%3BHill%2C+Georgette%3BSeely%2C+John%3BHailey%2C+James+R%3BKissling%2C+Grace%3BBucher%2C+John+R&rft.aulast=Doi&rft.aufirst=Adriana&rft.date=2007-06-01&rft.volume=35&rft.issue=4&rft.spage=533&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1080%2F01926230701338941 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Propylene glycol; Carcinogenesis; Nephropathy; Solvents; Kidney; Ethers; Tumors; Cell proliferation; Mineralization; Cancer DO - http://dx.doi.org/10.1080/01926230701338941 ER - TY - JOUR T1 - A liquid chromatography-mass spectrometry method for the quantitative analysis of urinary endogenous estrogen metabolites AN - 20338864; 7636101 AB - The ability to measure estrogen metabolites (EMs) quantitatively is important for investigating their individual roles in cancer screening, treatment and prevention, as well as in a host of other hormone-related disorders. In this protocol we describe a method that is capable of quantitating 15 distinct EMs in urine. Endogenous EMs are quantitatively measured using a liquid chromatography-tandem mass spectrometry method in which the spectrometer operates in a selected reaction monitoring mode. This method is capable of quantifying estrone and its 2-, and 4- and 16[alpha]- hydroxy and its 2-, 4-methoxy derivatives, and 2-hydroxyestrone-3-methyl ether; 17[beta]-estradiol and its 2-hydroxy, and 2- and 4-methoxy derivates, and estriol, 16-epiestriol, 17-epiestriol, and 16-ketoestradiol. The method requires only 0.5 ml of urine and approximately 60 urine samples can be quantitatively analyzed per week. JF - Nature Protocols AU - Xu, Xia AU - Keefer, Larry K AU - Ziegler, Regina G AU - Veenstra, Timothy D Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1350 EP - 1355 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 2 IS - 6 SN - 1754-2189, 1754-2189 KW - Biotechnology and Bioengineering Abstracts KW - Estrogens KW - Urine KW - Metabolites KW - Ethers KW - Cancer KW - Mass spectroscopy KW - Spectrometry KW - Estrone KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20338864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Protocols&rft.atitle=A+liquid+chromatography-mass+spectrometry+method+for+the+quantitative+analysis+of+urinary+endogenous+estrogen+metabolites&rft.au=Xu%2C+Xia%3BKeefer%2C+Larry+K%3BZiegler%2C+Regina+G%3BVeenstra%2C+Timothy+D&rft.aulast=Xu&rft.aufirst=Xia&rft.date=2007-06-01&rft.volume=2&rft.issue=6&rft.spage=1350&rft.isbn=&rft.btitle=&rft.title=Nature+Protocols&rft.issn=17542189&rft_id=info:doi/10.1038%2Fnprot.2007.176 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Urine; Metabolites; Estrogens; Ethers; Estrone; Spectrometry; Mass spectroscopy; Cancer DO - http://dx.doi.org/10.1038/nprot.2007.176 ER - TY - JOUR T1 - Deconstructing common variable immunodeficiency by genetic analysis AN - 20312721; 7657046 AB - Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency. Patients have recurrent bacterial infections and an increased risk of developing autoimmune diseases, lung damage, and selected cancers. Since 2003, four genes have been shown to be mutated in CVID patients: ICOS, TNFRSF13B (encoding TACI), TNFRSF13C (encoding BAFF-R) and CD19. Heterozygous mutations in TNFRSF13B are also associated with CVID, whereas the other three genes are purely recessive. Recent genetic linkage studies have also identified possible loci for dominant CVID genes on chromosomes 4q, 5p and 16q. These findings markedly improved the genetic diagnosis of CVID and point towards new strategies for future genetic studies. In addition, some CVID genes might be relevant to more common diseases such as asthma and stroke. JF - Current Opinion in Genetics & Development AU - Schaffer, Alejandro A AU - Salzer, Ulrich AU - Hammarstrom, Lennart AU - Grimbacher, Bodo AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Department of Heath and Human Services, 8600 Rockvile Pike, Bethesda, MD 20894, USA, b.grimbacher@medsch.ucl.ac.uk Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 201 EP - 212 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 17 IS - 3 SN - 0959-437X, 0959-437X KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Immunology Abstracts KW - Common variable immunodeficiency KW - Autoimmune diseases KW - Stroke KW - Genetic analysis KW - Lung diseases KW - Asthma KW - chromosome 4 KW - Cancer KW - ICOS protein KW - Risk factors KW - Reviews KW - Recurrent infection KW - Mutation KW - CD19 antigen KW - G 07880:Human Genetics KW - J 02320:Cell Biology KW - F 06950:Immunogenetics, MHC, HLA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20312721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Genetics+%26+Development&rft.atitle=Deconstructing+common+variable+immunodeficiency+by+genetic+analysis&rft.au=Schaffer%2C+Alejandro+A%3BSalzer%2C+Ulrich%3BHammarstrom%2C+Lennart%3BGrimbacher%2C+Bodo&rft.aulast=Schaffer&rft.aufirst=Alejandro&rft.date=2007-06-01&rft.volume=17&rft.issue=3&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Genetics+%26+Development&rft.issn=0959437X&rft_id=info:doi/10.1016%2Fj.gde.2007.04.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Common variable immunodeficiency; Genetic analysis; Stroke; Autoimmune diseases; Lung diseases; Asthma; chromosome 4; Cancer; ICOS protein; Reviews; Risk factors; Recurrent infection; Mutation; CD19 antigen DO - http://dx.doi.org/10.1016/j.gde.2007.04.002 ER - TY - JOUR T1 - Efficient Method of Cloning the Obligate Intracellular Bacterium Coxiella burnetii AN - 20260009; 7459681 AB - Coxiella burnetii is an obligate intracellular bacterium that replicates in a large lysosome-like parasitophorous vacuole (PV). Current methods of cloning C. burnetii are laborious and technically demanding. We have developed an alternative cloning method that involves excision of individual C. burnetii-laden PVs from infected cell monolayers by micromanipulation. To demonstrate the cloning utility and efficiency of this procedure, we coinfected Vero cells with isogenic variants of the Nine Mile strain of C. burnetii. Coinhabited PVs harboring Nine Mile phase II (NMII) and Nine Mile phase I (NMI) or Nine Mile crazy (NMC) were demonstrated by immunofluorescence. PVs were then randomly excised from cells coinfected with NMI and NMC by micromanipulation, and PVs harboring both strains were identified by PCR. Fresh Vero cells were subsequently infected with organisms from coinhabited PVs, and the PV excision and PCR screening process was repeated. Without exception, PVs obtained from second-round excisions contained clonal populations of either NMII or NMC, demonstrating that micromanipulation is an efficient and reproducible procedure for obtaining C. burnetii clones. JF - Applied and Environmental Microbiology AU - Beare, Paul A AU - Howe, Dale AU - Cockrell, Diane C AU - Heinzen, Robert A AD - Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, 903 S. 4th St., Hamilton, Montana 59840 Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 4048 EP - 4054 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 73 IS - 12 SN - 0099-2240, 0099-2240 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology; Aqualine Abstracts KW - Vero cells KW - Immunofluorescence KW - Strain KW - Utilities KW - parasitophorous vacuole KW - Coxiella burnetii KW - Microorganisms KW - Polymerase chain reaction KW - AQ 00001:Water Resources and Supplies KW - W 30925:Genetic Engineering KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20260009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Efficient+Method+of+Cloning+the+Obligate+Intracellular+Bacterium+Coxiella+burnetii&rft.au=Beare%2C+Paul+A%3BHowe%2C+Dale%3BCockrell%2C+Diane+C%3BHeinzen%2C+Robert+A&rft.aulast=Beare&rft.aufirst=Paul&rft.date=2007-06-01&rft.volume=73&rft.issue=12&rft.spage=4048&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Coxiella burnetii; Strain; Utilities; Microorganisms; Vero cells; Polymerase chain reaction; Immunofluorescence; parasitophorous vacuole ER - TY - JOUR T1 - Neonatal dopamine depletion induces changes in morphogenesis and gene expression in the developing cortex AN - 20142352; 10263299 AB - The mesocorticolimbic dopamine (DA) system is implicated in mental health disorders affecting attention, impulse inhibition and other cognitive functions. It has also been involved in the regulation of cortical morphogenesis. The present study uses focal injections of 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle of BALB/c mice to examine morphological, behavioral and transcriptional responses to selective DA deficit in the fronto-parietal cortex. Mice that received injections of 6-OHDA on postnatal day 1 (PND1) showed reduction in DA levels in their cortices at PND7. Histological analysis at PND120 revealed increased fronto-cortical width, but decreased width of somatosensory parietal cortex. Open field object recognition suggested impaired response inhibition in adult mice after 6-OHDA treatment. Transcriptional analyses using 17K mouse microarrays showed that such lesions caused up-regulation of 100 genes in the cortex at PND7. Notably, among these genes are Sema3A which plays a repulsive role in axonal guidance, RhoD which inhibits dendritic growth and tubulin beta 5 microtubule subunit. In contrast, 127 genes were down-regulated, including CCT epsilon and CCT direct sum that play roles in actin and tubulin folding. Thus, neonatal DA depletion affects transcripts involved in control of cytoskeletal formation and pathway finding, instrumental for normal differentiation and synaptogenesis. The observed gene expression changes are consistent with histological cortical and behavioral impairments in the adult mice treated with 6-OHDA on PND1. Our results point towards specific molecular targets that might be involved in disease process mediated by altered developmental DA regulation. JF - Neurotoxicity Research AU - Krasnova, Irina N AU - Betts, Elizabeth S AU - Dada, Abiola AU - Jefferson, Akilah AU - Ladenheim, Bruce AU - Becker, Kevin G AU - Cadet, Jean Lud AU - Hohmann, Christine F AD - Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, NIH/DHHS, 21251 Baltimore, MD, USA, chohmann@jewel.morgan.edu Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 107 EP - 130 PB - Taylor & Francis Group Ltd., 2 Park Square Milton Park, Abingdon Oxford OX14 4RN UK, [URL:http://www.taylorandfrancis.co.uk/] VL - 11 IS - 2 SN - 1029-8428, 1029-8428 KW - Toxicology Abstracts; Genetics Abstracts; CSA Neurosciences Abstracts KW - Microtubules KW - Morphogenesis KW - Axon guidance KW - Transcription KW - DNA microarrays KW - Gene expression KW - Cortex (parietal) KW - Cytoskeleton KW - Differentiation KW - Pattern recognition KW - Mental disorders KW - Dopamine KW - Cognitive ability KW - Synaptogenesis KW - 6-Hydroxydopamine KW - Neurotoxicity KW - Actin KW - Neonates KW - Tubulin KW - Attention KW - semaphorins KW - Medial forebrain bundle KW - Cortex (somatosensory) KW - N3 11028:Neuropharmacology & toxicology KW - G 07730:Development & Cell Cycle KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20142352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicity+Research&rft.atitle=Neonatal+dopamine+depletion+induces+changes+in+morphogenesis+and+gene+expression+in+the+developing+cortex&rft.au=Krasnova%2C+Irina+N%3BBetts%2C+Elizabeth+S%3BDada%2C+Abiola%3BJefferson%2C+Akilah%3BLadenheim%2C+Bruce%3BBecker%2C+Kevin+G%3BCadet%2C+Jean+Lud%3BHohmann%2C+Christine+F&rft.aulast=Krasnova&rft.aufirst=Irina&rft.date=2007-06-01&rft.volume=11&rft.issue=2&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Neurotoxicity+Research&rft.issn=10298428&rft_id=info:doi/10.1007%2FBF03033390 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Microtubules; Morphogenesis; Axon guidance; Transcription; DNA microarrays; Cytoskeleton; Cortex (parietal); Gene expression; Pattern recognition; Differentiation; Mental disorders; Dopamine; Synaptogenesis; Cognitive ability; 6-Hydroxydopamine; Neurotoxicity; Actin; Neonates; Tubulin; semaphorins; Attention; Cortex (somatosensory); Medial forebrain bundle DO - http://dx.doi.org/10.1007/BF03033390 ER - TY - JOUR T1 - A new strategy for assessing selenoprotein function: siRNA knockdown/knock-in targeting the 3'-UTR AN - 20126739; 7421605 AB - Selenocysteine insertion into protein in mammalian cells requires RNA elements in the 3'-untranslated regions (3'-UTRs) of selenoprotein genes. The occurrence of these conserved sequences should make selenoproteins particularly amenable for knockdown/knock-in strategies to examine selenoprotein functions. Herein, we utilized the 3'-UTR of various selenoproteins to knock down their expression using siRNAs and then knock in expression using constructs containing mutations within the target region. Thioredoxin reductase 1 (TR1) knockdown in a mouse kidney cell line resulted in the cells growing about 10% more slowly, being more sensitive to UV radiation, and having increased apoptosis in response to UV than control cells. The knockdown cells transfected with a construct encoding the wild-type TR1 gene and having mutations in the sequences targeted by siRNA restored TR1 expression and catalytic activity, rendered the knockdown cells less sensitive to UV, and protected the cells against apoptosis. We also applied this technique to other selenoproteins, selenophosphate synthetase 2 and glutathione peroxidase 1, and found that mRNA and protein levels were restored following transfection of knockdown cells with the corresponding knock-in constructs. In addition to important new insights into the functions of key mammalian selenoproteins, the data suggest that the RNAi-based knock-in technology could distinguish phenotypes due to off-targeting and provide a new method for examining many of the subtleties of selenoprotein function not available using RNAi technology alone. JF - RNA AU - Yoo, Min-Hyuk AU - Xu, Xue-Ming AU - Turanov, Anton A AU - Carlson, Bradley A AU - Gladyshev, Vadim N AU - Hatfield, Dolph L AD - Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, USA. Department of Biochemistry, University of Nebraska, Lincoln, Nebraska 68588, USA Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 921 EP - 929 PB - Cold Spring Harbor Laboratory Press, Fulfillment & Distribution Dept. 500 Sunnyside Boulevard Woodbury NY 11797-2924 USA, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 13 IS - 6 SN - 1355-8382, 1355-8382 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Apoptosis KW - selenoproteins KW - Data processing KW - 3' Untranslated regions KW - Selenocysteine KW - Thioredoxin-disulfide reductase KW - mRNA KW - U.V. radiation KW - Mammalian cells KW - siRNA KW - Transfection KW - Glutathione peroxidase KW - thioredoxin reductase KW - Kidney KW - RNA-mediated interference KW - selenophosphate synthetase 2 KW - Mutation KW - W 30905:Medical Applications KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20126739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=RNA&rft.atitle=A+new+strategy+for+assessing+selenoprotein+function%3A+siRNA+knockdown%2Fknock-in+targeting+the+3%27-UTR&rft.au=Yoo%2C+Min-Hyuk%3BXu%2C+Xue-Ming%3BTuranov%2C+Anton+A%3BCarlson%2C+Bradley+A%3BGladyshev%2C+Vadim+N%3BHatfield%2C+Dolph+L&rft.aulast=Yoo&rft.aufirst=Min-Hyuk&rft.date=2007-06-01&rft.volume=13&rft.issue=6&rft.spage=921&rft.isbn=&rft.btitle=&rft.title=RNA&rft.issn=13558382&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Data processing; selenoproteins; Apoptosis; 3' Untranslated regions; Selenocysteine; Thioredoxin-disulfide reductase; mRNA; U.V. radiation; siRNA; Mammalian cells; Glutathione peroxidase; Transfection; Kidney; thioredoxin reductase; selenophosphate synthetase 2; RNA-mediated interference; Mutation ER - TY - JOUR T1 - Novel Engineered Trastuzumab Conformational Epitopes Demonstrate In Vitro and In Vivo Antitumor Properties against HER-2/neu AN - 20097604; 7419290 AB - Trastuzumab is a growth-inhibitory humanized Ab targeting the oncogenic protein HER-2/neu. Although trastuzumab is approved for treatment of advanced breast cancer, a number of concerns exist with passive immunotherapy. Treatment is expensive and has a limited duration of action, necessitating repeated administrations of the mAb. Active immunotherapy with conformational B cell epitopes affords the possibility of generating an enduring immune response, eliciting protein-reactive high-affinity anti-peptide Abs. The three-dimensional structure of human HER-2 in complex with trastuzumab reveals that the Ag-binding region of HER-2 spans residues 563-626 that comprises an extensive disulfide-bonding pattern. To delineate the binding region of HER-2, we have designed four synthetic peptides with different levels of conformational flexibility. Chimeric peptides incorporating the measles virus fusion "promiscuous" T cell epitope via a four-residue linker sequence were synthesized, purified, and characterized. All conformational peptides were recognized by trastuzumab and prevented the function of trastuzumab inhibiting tumor cell proliferation, with 563-598 and 597-626 showing greater reactivity. All epitopes were immunogenic in FVB/N mice with Abs against 597-626 and 613-626 recognizing HER-2. The 597-626 epitope was immunogenic in outbred rabbits eliciting Abs which recognized HER-2, competed with trastuzumab for the same epitope, inhibited proliferation of HER-2-expressing breast cancer cells in vitro and caused their Ab-dependent cell-mediated cytotoxicity. Moreover, immunization with the 597-626 epitope significantly reduced tumor burden in transgenic BALB-neuT mice. These results suggest the peptide B cell immunogen is appropriate as a vaccine for HER-2-overexpressing cancers because the resulting Abs show analogous biological properties to trastuzumab. JF - Journal of Immunology AU - Garrett, Joan T AU - Rawale, Sharad AU - Allen, Stephanie D AU - Phillips, Gary AU - Forni, Guido AU - Morris, John C AU - Kaumaya, Pravin TP AD - Departments of Obstetrics and Gynecology, Chemistry Biology Interface Program, Ohio State Biochemistry Program, Center for Biostatistics, Molecular Virology, Immunology, Medical Genetics, and. Arthur G. James Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210. Molecular Biology Center, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy. Metabolism Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 Y1 - 2007/06/01/ PY - 2007 DA - 2007 Jun 01 SP - 7120 EP - 7131 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 178 IS - 11 SN - 0022-1767, 0022-1767 KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - ErbB-2 protein KW - synthetic peptides KW - Monoclonal antibodies KW - Lymphocytes B KW - Immunotherapy KW - Tumors KW - Measles virus KW - Transgenic mice KW - trastuzumab KW - Tumor cells KW - Cell fusion KW - Immunogenicity KW - Lymphocytes T KW - Breast cancer KW - Antibody-dependent cell-mediated cytotoxicity KW - Vaccines KW - Cell proliferation KW - Epitopes KW - V 22350:Immunology KW - F 06915:Cancer Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20097604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Novel+Engineered+Trastuzumab+Conformational+Epitopes+Demonstrate+In+Vitro+and+In+Vivo+Antitumor+Properties+against+HER-2%2Fneu&rft.au=Garrett%2C+Joan+T%3BRawale%2C+Sharad%3BAllen%2C+Stephanie+D%3BPhillips%2C+Gary%3BForni%2C+Guido%3BMorris%2C+John+C%3BKaumaya%2C+Pravin+TP&rft.aulast=Garrett&rft.aufirst=Joan&rft.date=2007-06-01&rft.volume=178&rft.issue=11&rft.spage=7120&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - synthetic peptides; ErbB-2 protein; Lymphocytes B; Monoclonal antibodies; Immunotherapy; Tumors; trastuzumab; Transgenic mice; Tumor cells; Cell fusion; Immunogenicity; Lymphocytes T; Breast cancer; Antibody-dependent cell-mediated cytotoxicity; Vaccines; Cell proliferation; Epitopes; Measles virus ER - TY - JOUR T1 - A Novel Bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI), GRL-98065, Is Potent against Multiple-PI-Resistant Human Immunodeficiency Virus In Vitro AN - 19998691; 7414256 AB - We designed, synthesized, and identified GRL-98065, a novel nonpeptidic human immunodeficiency virus type 1 (HIV-1) protease inhibitor (PI) containing the structure-based designed privileged cyclic ether-derived nonpeptide P2 ligand, 3(R),3a(S),6a(R)-bis-tetrahydrofuranylurethane (bis-THF), and a sulfonamide isostere, which is highly potent against laboratory HIV-1 strains and primary clinical isolates (50% effective concentration [EC sub(50)], 0.0002 to 0.0005 mu M) with minimal cytotoxicity (50% cytotoxicity, 35.7 mu M in CD4 super(+) MT-2 cells). GRL-98065 blocked the infectivity and replication of each of the HIV-1 sub(NL4-3) variants exposed to and selected by up to a 5 mu M concentration of saquinavir, indinavir, nelfinavir, or ritonavir and a 1 mu M concentration of lopinavir or atazanavir (EC sub(50), 0.0015 to 0.0075 mu M), although it was less active against HIV-1 sub(NL4-3) selected by amprenavir (EC sub(50), 0.032 mu M). GRL-98065 was also potent against multiple-PI-resistant clinical HIV-1 variants isolated from patients who had no response to existing antiviral regimens after having received a variety of antiviral agents, HIV-1 isolates of various subtypes, and HIV-2 isolates examined. Structural analyses revealed that the close contact of GRL-98065 with the main chain of the protease active-site amino acids (Asp29 and Asp30) is important for its potency and wide-spectrum activity against multiple-PI-resistant HIV-1 variants. The present data demonstrate that the privileged nonpeptide P2 ligand, bis-THF, is critical for the binding of GRL-98065 to the HIV protease substrate binding site and that this scaffold can confer highly potent antiviral activity against a wide spectrum of HIV isolates. JF - Antimicrobial Agents & Chemotherapy AU - Amano, Masayuki AU - Koh, Yasuhiro AU - Das, Debananda AU - Li, Jianfeng AU - Leschenko, Sofiya AU - Wang, Yuan-Fang AU - Boross, Peter I AU - Weber, Irene T AU - Ghosh, Arun K AU - Mitsuya, Hiroaki AD - Department of Infectious Diseases. Department of Hematology, Kumamoto University School of Medicine, Kumamoto 860-8556, Japan. Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892. Departments of Chemistry and Medicinal Chemistry, Purdue University, West Lafayette, Indiana 47907. Department of Biology, Georgia State University, Atlanta, Georgia 30303. Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 2143 EP - 2155 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 51 IS - 6 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Clinical isolates KW - Amino acids KW - Data processing KW - Indinavir KW - Replication KW - Saquinavir KW - Proteinase inhibitors KW - Antiviral activity KW - scaffolds KW - Antimicrobial agents KW - Infectivity KW - CD4 antigen KW - Cytotoxicity KW - Lopinavir KW - Antiviral agents KW - Ritonavir KW - Human immunodeficiency virus 1 KW - Human immunodeficiency virus 2 KW - Nelfinavir KW - Sulfonamides KW - amprenavir KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19998691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=A+Novel+Bis-Tetrahydrofuranylurethane-Containing+Nonpeptidic+Protease+Inhibitor+%28PI%29%2C+GRL-98065%2C+Is+Potent+against+Multiple-PI-Resistant+Human+Immunodeficiency+Virus+In+Vitro&rft.au=Amano%2C+Masayuki%3BKoh%2C+Yasuhiro%3BDas%2C+Debananda%3BLi%2C+Jianfeng%3BLeschenko%2C+Sofiya%3BWang%2C+Yuan-Fang%3BBoross%2C+Peter+I%3BWeber%2C+Irene+T%3BGhosh%2C+Arun+K%3BMitsuya%2C+Hiroaki&rft.aulast=Amano&rft.aufirst=Masayuki&rft.date=2007-06-01&rft.volume=51&rft.issue=6&rft.spage=2143&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Data processing; Amino acids; Indinavir; Saquinavir; Replication; Proteinase inhibitors; Antiviral activity; scaffolds; Antimicrobial agents; Cytotoxicity; CD4 antigen; Infectivity; Antiviral agents; Lopinavir; Ritonavir; Nelfinavir; Sulfonamides; amprenavir; Human immunodeficiency virus 1; Human immunodeficiency virus 2 ER - TY - JOUR T1 - Clinical Response and Tolerability to and Safety of Saquinavir with Low-Dose Ritonavir in Human Immunodeficiency Virus Type 1-Infected Mothers and Their Infants AN - 19994763; 7414268 AB - Saquinavir boosted with low-dose ritonavir given with zidovudine and lamivudine was well tolerated by pregnant women and their infants. All mothers had <400 human immunodeficiency virus type 1 RNA copies/ml at delivery. Two had elevated liver transaminases and amylase. Seven infant adverse events were possibly treatment related (anemia, neutropenia, and hyperbilirubinemia). JF - Antimicrobial Agents & Chemotherapy AU - Zorrilla, Carmen D AU - Van Dyke, Russell AU - Bardeguez, Arlene AU - Acosta, Edward P AU - Smith, Betsy AU - Hughes, Michael D AU - Huang, Sharon AU - Watts, DHeather AU - Heckman, Barbara AU - Jimenez, Eleanor AU - McSherry, George AU - Mofenson, Lynne AD - University of Puerto Rico School of Medicine, San Juan, Puerto Rico. Tulane University Medical School, New Orleans, Louisiana. New Jersey Medical School, Newark, New Jersey. University of Alabama at Birmingham, Birmingham, Alabama. Division of AIDS, NIAID, Bethesda, Maryland. Harvard School of Public Health, Boston, Massachusetts. Pediatric, Adolescent, and Maternal AIDS Branch, NICHD, Bethesda, Maryland. Frontier Science and Technology Research Foundation, Amherst, New York. San Juan City Hospital, San Juan, Puerto Rico Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 2208 EP - 2210 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 51 IS - 6 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Saquinavir KW - Anemia KW - Zidovudine KW - Lamivudine KW - RNA viruses KW - transaminase KW - Antimicrobial agents KW - Pregnancy KW - Neutropenia KW - RNA KW - Ritonavir KW - Hyperbilirubinemia KW - Human immunodeficiency virus 1 KW - Liver KW - Infants KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19994763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Clinical+Response+and+Tolerability+to+and+Safety+of+Saquinavir+with+Low-Dose+Ritonavir+in+Human+Immunodeficiency+Virus+Type+1-Infected+Mothers+and+Their+Infants&rft.au=Zorrilla%2C+Carmen+D%3BVan+Dyke%2C+Russell%3BBardeguez%2C+Arlene%3BAcosta%2C+Edward+P%3BSmith%2C+Betsy%3BHughes%2C+Michael+D%3BHuang%2C+Sharon%3BWatts%2C+DHeather%3BHeckman%2C+Barbara%3BJimenez%2C+Eleanor%3BMcSherry%2C+George%3BMofenson%2C+Lynne&rft.aulast=Zorrilla&rft.aufirst=Carmen&rft.date=2007-06-01&rft.volume=51&rft.issue=6&rft.spage=2208&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Saquinavir; Anemia; Lamivudine; Zidovudine; RNA viruses; transaminase; Pregnancy; Antimicrobial agents; Neutropenia; RNA; Ritonavir; Hyperbilirubinemia; Liver; Infants; Human immunodeficiency virus 1 ER - TY - JOUR T1 - Role of TLR4 Tyrosine Phosphorylation in Signal Transduction and Endotoxin Tolerance AN - 19982456; 7418688 AB - In this study, we examined whether tyrosine phosphorylation of the Toll-IL-1 resistance (TIR) domain of Toll-like receptor (TLR) 4 is required for signaling and blocked in endotoxin tolerance. Introduction of the P712H mutation, responsible for lipopolysaccharide (LPS) unresponsiveness of C3H/HeJ mice, into the TIR domain of constitutively active mouse Delta TLR4 and mutation of the homologous P714 in human CD4-TLR4 rendered them signaling-incompetent and blocked TLR4 tyrosine phosphorylation. Mutations of tyrosine residues Y674A and Y680A within the TIR domains of CD4-TLR4 impaired its ability to elicit phosphorylation of p38 and JNK mitogen-activated protein kinases, I Kappa B- alpha degradation, and activation of NF- Kappa B and RANTES reporters. Likewise, full-length human TLR4 expressing Y674A or Y680A mutations showed suppressed capacities to mediate LPS-inducible cell activation. Signaling deficiencies of the Y674A and Y680A TLR4s correlated with altered MyD88-TLR4 interactions, increased associations with a short IRAK-1 isoform, and decreased amounts of activated IRAK-1 in complex with TLR4. Pretreatment of human embryonic kidney (HEK) 293/TLR4/MD-2 cells with protein tyrosine kinase or Src kinase inhibitors suppressed LPS-driven TLR4 tyrosine phosphorylation, p38 and NF- Kappa B activation. TLR2 and TLR4 agonists induced TLR tyrosine phosphorylation in HEK293 cells overexpressing CD14, MD-2, and TLR4 or TLR2. Induction of endotoxin tolerance in HEK293/TLR4/MD-2 transfectants and in human monocytes markedly suppressed LPS-mediated TLR4 tyrosine phosphorylation and recruitment of Lyn kinase to TLR4, but did not affect TLR4-MD-2 interactions. Thus, our data demonstrate that TLR4 tyrosine phosphorylation is important for signaling and is impaired in endotoxin-tolerant cells, and suggest involvement of Lyn kinase in these processes. JF - Journal of Biological Chemistry AU - Medvedev, Andrei E AU - Piao, Wenji AU - Shoenfelt, Joanna AU - Rhee, Sang Hoon AU - Chen, Haiyan AU - Basu, Subhendu AU - Wahl, Larry M AU - Fenton, Matthew J AU - Vogel, Stefanie N AD - Departments of Microbiology and Immunology and Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, the Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, and the NIDCR, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2007/06/01/ PY - 2007 DA - 2007 Jun 01 SP - 16042 EP - 16053 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 22 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Endotoxins KW - MAP kinase KW - c-Jun amino-terminal kinase KW - Data processing KW - TLR2 protein KW - RANTES KW - CD14 antigen KW - NF- Kappa B protein KW - Cell activation KW - CD4 antigen KW - IRAK protein KW - Phosphorylation KW - Protein-tyrosine kinase KW - Src protein KW - Lipopolysaccharides KW - Embryos KW - Monocytes KW - Mutation KW - TLR4 protein KW - Lyn protein KW - Toll-like receptors KW - Signal transduction KW - A 01490:Miscellaneous KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19982456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Role+of+TLR4+Tyrosine+Phosphorylation+in+Signal+Transduction+and+Endotoxin+Tolerance&rft.au=Medvedev%2C+Andrei+E%3BPiao%2C+Wenji%3BShoenfelt%2C+Joanna%3BRhee%2C+Sang+Hoon%3BChen%2C+Haiyan%3BBasu%2C+Subhendu%3BWahl%2C+Larry+M%3BFenton%2C+Matthew+J%3BVogel%2C+Stefanie+N&rft.aulast=Medvedev&rft.aufirst=Andrei&rft.date=2007-06-01&rft.volume=282&rft.issue=22&rft.spage=16042&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Endotoxins; MAP kinase; Data processing; c-Jun amino-terminal kinase; TLR2 protein; RANTES; CD14 antigen; Cell activation; NF- Kappa B protein; CD4 antigen; Phosphorylation; IRAK protein; Protein-tyrosine kinase; Src protein; Lipopolysaccharides; Embryos; Monocytes; TLR4 protein; Mutation; Toll-like receptors; Lyn protein; Signal transduction ER - TY - JOUR T1 - Gene Expression Analysis of Hematopoietic Progenitor Cells Identifies Dlg7 as a Potential Stem Cell Gene AN - 19977722; 7465202 AB - Inducible hematopoietic stem/progenitor cell lines represent a model for studying genes involved in self-renewal and differentiation. Here, gene expression was studied in the inducible human CD34+ acute myelogenous leukemia cell line KG1 using oligonucleotide arrays and suppression subtractive cloning. Using this approach, we identified Dlg7, the homolog of the Drosophila Dlg1 tumor suppressor gene, as downregulated at the early stages of KG1 differentiation. Similarly, Dlg7 was expressed in normal purified umbilical cord blood CD34+CD38- progenitors but not in the more committed CD34+CD38+ population. Dlg7 expression was not detected in differentiated cells obtained from hematopoietic colonies, nor was expression detected in purified T-cells, B-cells, and monocytes. When analyzed in different types of stem cells, Dlg7 expression was detected in purified human bone marrow-derived CD133+ progenitor cells, human mesenchymal stem cells, and mouse embryonic stem (ES) cells. Overexpression of Dlg7 in mouse ES cells increased their growth rate and reduced the number of EBs emerging upon differentiation. In addition, the EBs were significantly smaller, indicating an inhibition in differentiation. This inhibition was further supported by higher expression of Bmp4, Oct4, Rex1, and Nanog in EBs overexpressing Dlg7 and lower expression of BRACHYURY: Finally, the Dlg7 protein was detected in liver and colon carcinoma tumors but not in normal adjacent tissues, suggesting a role for the gene in carcinogenesis. In conclusion, our results suggest that Dlg7 has a role in stem cell survival, in maintaining stem cell properties, and in carcinogenesis. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Gudmundsson, Kristbjorn Orri AU - Thorsteinsson, Leifur AU - Sigurjonsson, Olafur E AU - Keller, Jonathan R AU - Olafsson, Karl AU - Egeland, Torstein AU - Gudmundsson, Sveinn AU - Rafnar, Thorunn AD - Blood Bank and Department of Obstetrics and Gynecology, Landspitali-University Hospital, Reykjavik, Iceland. Institute of Immunology, University Hospital, Oslo, Norway. Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research, National Cancer Institute-Frederick, NIH, Frederick, Maryland, USA. Iceland Genomics Corporation, Reykjavik, Iceland Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1498 EP - 1506 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 25 IS - 6 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Cell survival KW - Tumor suppressor genes KW - Acute myeloid leukemia KW - Animal models KW - Bone marrow KW - DNA microarrays KW - Umbilical cord KW - Gene expression KW - Differentiation KW - Tumor cell lines KW - Stem cells KW - Colonies KW - Colon KW - Osteoprogenitor cells KW - Lymphocytes T KW - Embryos KW - Monocytes KW - Mesenchyme KW - Oct-4 protein KW - Growth rate KW - Lymphocytes B KW - Cloning KW - CD34 antigen KW - Tumors KW - Carcinogenesis KW - Liver KW - Hemopoiesis KW - Drosophila KW - Bone morphogenetic protein 4 KW - W 30925:Genetic Engineering KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19977722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Gene+Expression+Analysis+of+Hematopoietic+Progenitor+Cells+Identifies+Dlg7+as+a+Potential+Stem+Cell+Gene&rft.au=Gudmundsson%2C+Kristbjorn+Orri%3BThorsteinsson%2C+Leifur%3BSigurjonsson%2C+Olafur+E%3BKeller%2C+Jonathan+R%3BOlafsson%2C+Karl%3BEgeland%2C+Torstein%3BGudmundsson%2C+Sveinn%3BRafnar%2C+Thorunn&rft.aulast=Gudmundsson&rft.aufirst=Kristbjorn&rft.date=2007-06-01&rft.volume=25&rft.issue=6&rft.spage=1498&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell survival; Tumor suppressor genes; Acute myeloid leukemia; Bone marrow; Animal models; DNA microarrays; Umbilical cord; Gene expression; Differentiation; Colonies; Stem cells; Tumor cell lines; Colon; Lymphocytes T; Osteoprogenitor cells; Embryos; Monocytes; Oct-4 protein; Mesenchyme; Growth rate; Lymphocytes B; Cloning; CD34 antigen; Tumors; Carcinogenesis; Liver; Hemopoiesis; Bone morphogenetic protein 4; Drosophila ER - TY - JOUR T1 - Simultaneous Multicolor Imaging of Five Different Lymphatic Basins Using Quantum Dots AN - 19970842; 7599090 AB - Quantum dots can be used to perform multicolor images with high fluorescent intensity and are of a nanosize suitable for lymphatic imaging via direct interstitial injection. Here simultaneous multicolor in vivo wavelength-resolved spectral fluorescence lymphangiography is shown using five quantum dots with similar physical sizes but different emission spectra. This allows noninvasive and simultaneous visualization of five separate lymphatic flows draining and may have implications for predicting the route of cancer metastasis into the lymph nodes. JF - Nano Letters AU - Kobayashi, H AU - Hama, Y AU - Koyama, Y AU - Barrett, T AU - Regino, CAS AU - Urano, Y AU - Choyke, P L AD - Molecular Imaging Program and Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-1088, USA Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1711 EP - 1716 VL - 7 IS - 6 SN - 1530-6984, 1530-6984 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Metastases KW - Fluorescence KW - Quantum dots KW - Basins KW - imaging KW - Lymph nodes KW - Cancer KW - Lymphangiography KW - W 30910:Imaging KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19970842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nano+Letters&rft.atitle=Simultaneous+Multicolor+Imaging+of+Five+Different+Lymphatic+Basins+Using+Quantum+Dots&rft.au=Kobayashi%2C+H%3BHama%2C+Y%3BKoyama%2C+Y%3BBarrett%2C+T%3BRegino%2C+CAS%3BUrano%2C+Y%3BChoyke%2C+P+L&rft.aulast=Kobayashi&rft.aufirst=H&rft.date=2007-06-01&rft.volume=7&rft.issue=6&rft.spage=1711&rft.isbn=&rft.btitle=&rft.title=Nano+Letters&rft.issn=15306984&rft_id=info:doi/10.1021%2Fnl0707003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Metastases; Fluorescence; Quantum dots; Basins; imaging; Cancer; Lymph nodes; Lymphangiography DO - http://dx.doi.org/10.1021/nl0707003 ER - TY - JOUR T1 - The Novel Fold of Scytovirin Reveals a New Twist For Antiviral Entry Inhibitors AN - 19884716; 8240409 AB - The solution structure of the potent 95 residue anti-HIV protein scytovirin has been determined and two carbohydrate-binding sites have been identified. This unique protein, containing five structurally important disulfide bonds, demonstrates a novel fold with no elements of extended regular secondary structure. Scytovirin contains two 39 residue sequence repeats, differing in only three amino acid residues, and each repeat has primary sequence similarity to chitin binding proteins. Both sequence repeats form similarly structured domains, with the exception of one region. The result is two carbohydrate-binding sites with substantially different affinities. The unusual fold clusters aromatic residues in both sites, suggesting a binding mechanism similar to other known hevein-like carbohydrate-binding proteins but differing in carbohydrate specificity. Scytovirin, originally isolated from the cyanobacterium Scytonema varium, holds potential as an HIV entry inhibitor for both therapeutic and prophylactic anti-HIV applications. The high-resolution structural studies reported are an important initial step in unlocking the therapeutic potential of scytovirin. JF - Journal of Molecular Biology AU - McFeeters, R L AU - Xiong, C AU - O'Keefe, B R AU - Bokesch, H R AU - McMahon, J B AU - Ratner, D M AU - Castelli, R AU - Seeberger, PH AU - Byrd, R A AD - National Cancer Institute, Frederick, MD 21702-1201, USA, rabyrd@ncifcrf.gov Y1 - 2007/06/01/ PY - 2007 DA - 2007 Jun 01 SP - 451 EP - 461 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 369 IS - 2 SN - 0022-2836, 0022-2836 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Protein structure KW - Protein folding KW - Human immunodeficiency virus KW - Secondary structure KW - Disulfide bonds KW - Chitin KW - Scytonema KW - Carbohydrates KW - Cyanophyta KW - Aromatics KW - Amino acid sequence KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - K 03330:Biochemistry KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19884716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=The+Novel+Fold+of+Scytovirin+Reveals+a+New+Twist+For+Antiviral+Entry+Inhibitors&rft.au=McFeeters%2C+R+L%3BXiong%2C+C%3BO%27Keefe%2C+B+R%3BBokesch%2C+H+R%3BMcMahon%2C+J+B%3BRatner%2C+D+M%3BCastelli%2C+R%3BSeeberger%2C+PH%3BByrd%2C+R+A&rft.aulast=McFeeters&rft.aufirst=R&rft.date=2007-06-01&rft.volume=369&rft.issue=2&rft.spage=451&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2007.03.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Protein structure; Protein folding; Secondary structure; Chitin; Disulfide bonds; Carbohydrates; Aromatics; Amino acid sequence; Human immunodeficiency virus; Scytonema; Cyanophyta DO - http://dx.doi.org/10.1016/j.jmb.2007.03.030 ER - TY - JOUR T1 - Tubulin Is a Neuronal Target of Autoantibodies in Sydenham's Chorea AN - 19878698; 7419321 AB - Sydenham's chorea is a CNS disorder and sequela of group A streptococcal infection where deposition of Abs in brain may result in movement and neuropsychiatric abnormalities. We studied human mAbs 24.3.1, 31.1.1, and 37.2.1 derived from chorea and selected for cross-reactivity with group A streptococci and brain Ags. Our novel findings reveal that Sydenham's chorea mAbs target a 55-kDa brain protein with an N-terminal amino acid sequence of MREIVHLQ corresponding to beta -tubulin. Chorea mAb specificity for purified brain tubulin was confirmed in ELISA and Western immunoblot, and significant levels of anti-tubulin IgG were found in acute chorea sera and cerebrospinal fluid. Lysoganglioside G sub(M1) inhibited binding of chorea mAbs to tubulin and mAb reactivity with human caudate and putamen brain sections was blocked by anti-tubulin mAb. The chorea mAbs labeled both intra- and extracellular Ags of a neuronal cell line providing evidence suggesting mimicry between intracellular brain protein tubulin and extracellular lysoganglioside. In addition, chorea mAb 24.3.1 and acute chorea sera induced calcium/calmodulin-dependent protein kinase II activity in human neuronal cells. Nucleotide sequence analysis of the chorea mAb V sub(H) genes revealed that mAb 24.3.1 V sub(H) gene was encoded by the V sub(H)1 germline gene family which encodes other anti-ganglioside V sub(H) genes associated with motor neuropathies. mAb recognition of tubulin and the neuronal cell surface with initiation of cell signaling and dopamine release supports an emerging theme in autoimmunity whereby cross-reactive or polyreactive autoantibodies against intracellular Ags recognize cell surface epitopes potentially leading to disease. JF - Journal of Immunology AU - Kirvan, Christine A AU - Cox, Carol J AU - Swedo, Susan E AU - Cunningham, Madeleine W AD - Department of Biological Sciences, California State University, Sacramento, CA 95819. Department of Microbiology and Immunology, University of Oklahoma, Oklahoma, City, OK 73104. Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 Y1 - 2007/06/01/ PY - 2007 DA - 2007 Jun 01 SP - 7412 EP - 7421 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 178 IS - 11 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts; CSA Neurosciences Abstracts KW - Cell surface KW - Central nervous system KW - Cross-reactivity KW - Calcium KW - Nucleotide sequence KW - Autoimmune diseases KW - Infection KW - Putamen KW - Mental disorders KW - Cerebrospinal fluid KW - Dopamine KW - Ca super(2+)/calmodulin-dependent protein kinase II KW - Epitopes KW - Neuropathy KW - Streptococcus KW - Intracellular signalling KW - Mimicry KW - Enzyme-linked immunosorbent assay KW - Monoclonal antibodies KW - Brain KW - Chorea KW - Autoantibodies KW - Ca super(2+)/calmodulin-dependent protein kinase KW - Immunoglobulin G KW - Tubulin KW - Amino acid sequence KW - N 14815:Nucleotide Sequence KW - J 02350:Immunology KW - F 06930:Autoimmunity KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19878698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Tubulin+Is+a+Neuronal+Target+of+Autoantibodies+in+Sydenham%27s+Chorea&rft.au=Kirvan%2C+Christine+A%3BCox%2C+Carol+J%3BSwedo%2C+Susan+E%3BCunningham%2C+Madeleine+W&rft.aulast=Kirvan&rft.aufirst=Christine&rft.date=2007-06-01&rft.volume=178&rft.issue=11&rft.spage=7412&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Central nervous system; Cell surface; Calcium; Cross-reactivity; Nucleotide sequence; Autoimmune diseases; Infection; Putamen; Cerebrospinal fluid; Mental disorders; Dopamine; Ca super(2+)/calmodulin-dependent protein kinase II; Epitopes; Neuropathy; Mimicry; Intracellular signalling; Enzyme-linked immunosorbent assay; Monoclonal antibodies; Brain; Chorea; Autoantibodies; Ca super(2+)/calmodulin-dependent protein kinase; Immunoglobulin G; Tubulin; Amino acid sequence; Streptococcus ER - TY - JOUR T1 - Liver regeneration is suppressed in alcoholic cirrhosis: correlation with decreased STAT3 activation AN - 19872652; 7511464 AB - Liver regeneration is suppressed in alcoholic patients; however, the underlying mechanisms are not fully understood. We examined liver regeneration and signal transducer and activator of transcription 3 (STAT3) activation (an important signal for liver regeneration) in cirrhotic livers from alcoholics, hepatitis C virus (HCV) infection, and alcoholic plus HCV infection. Liver regeneration and STAT3 activation were determined by immunohistochemistry analysis of Ki67 and STAT3 phosphorylation, respectively, in 20 alcoholic cirrhosis, 13 HCV cirrhosis, 13 alcoholic+HCV cirrhosis. Alcoholic or alcoholic plus HCV cirrhotic livers had significantly lower Ki67+ and phospho-STAT3+ (pSTAT3+) hepatocytes and bile duct cells than HCV cirrhotic livers. The pSTAT3 positive staining did not correlate with liver injury (elevation of serum levels of aspartate transaminase [AST] and alkaline phosphatase [ALP]) but correlated positively with cell proliferation (Ki67 positive staining). In conclusion: liver regeneration is suppressed in alcoholic cirrhotic livers, which may be partly due to decreased STAT3 activation. JF - Alcohol AU - Horiguchi, Norio AU - Ishac, Edward J N AU - Gao, Bin AD - Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Rm 2S-33, Bethesda, MD 20892, USA, bgao@mail.nih.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 271 EP - 280 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 41 IS - 4 SN - 0741-8329, 0741-8329 KW - Virology & AIDS Abstracts; Toxicology Abstracts KW - Alcohol KW - STAT3 KW - Liver regeneration KW - Cirrhosis KW - HCV KW - Cell proliferation KW - Bile duct KW - Injuries KW - Hepatocytes KW - Stat3 protein KW - Transcription KW - Infection KW - Alcoholics KW - Serum levels KW - Alkaline phosphatase KW - Hepatitis C virus KW - Phosphorylation KW - Aspartate transaminase KW - Liver KW - Immunohistochemistry KW - Ethanol KW - X 24380:Social Poisons & Drug Abuse KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19872652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol&rft.atitle=Liver+regeneration+is+suppressed+in+alcoholic+cirrhosis%3A+correlation+with+decreased+STAT3+activation&rft.au=Horiguchi%2C+Norio%3BIshac%2C+Edward+J+N%3BGao%2C+Bin&rft.aulast=Horiguchi&rft.aufirst=Norio&rft.date=2007-06-01&rft.volume=41&rft.issue=4&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Alcohol&rft.issn=07418329&rft_id=info:doi/10.1016%2Fj.alcohol.2007.04.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cirrhosis; Injuries; Bile duct; Stat3 protein; Hepatocytes; Transcription; Infection; Alcoholics; Serum levels; Alkaline phosphatase; Phosphorylation; Aspartate transaminase; Liver; Cell proliferation; Immunohistochemistry; Ethanol; Hepatitis C virus DO - http://dx.doi.org/10.1016/j.alcohol.2007.04.008 ER - TY - JOUR T1 - Mouse embryonic stem cells that express a NUP98-HOXD13 fusion protein are impaired in their ability to differentiate and can be complemented by BCR-ABL AN - 19861242; 7457248 AB - NUP98-HOXD13 (NHD13) fusions have been identified in patients with myelodysplastic syndrome, acute myelogenous leukemia and chronic myeloid leukemia blast crisis. We generated 'knock-in' mouse embryonic stem (ES) cells that express a NHD13 fusion gene from the endogenous murine NUP98 promoter, and used an in vitro differentiation system to differentiate the ES cells to hematopoietic colonies. Replating assays demonstrated that the partially differentiated NHD13 ES cells were immortal, and two of these cultures were transferred to liquid culture. These cell lines are partially differentiated immature hematopoietic cells, as determined by morphology, immunophenotype and gene expression profile. Despite these characteristics, they were unable to differentiate when exposed to high concentrations of erythropoietin (Epo), granulocyte colony-stimulating factor or macrophage colony-stimulating factor. The cell lines are incompletely transformed, as evidenced by their dependence on interleukin 3 (IL-3), and their failure to initiate tumors when injected into immunodeficient mice. We attempted genetic complementation of the NHD13 gene using IL-3 independence and tumorigenicity in immunodeficient mice as markers of transformation, and found that BCR-ABL successfully transformed the cell lines. These findings support the hypothesis that expression of a NHD13 fusion gene impairs hematopoietic differentiation, and that these cell lines present a model system to study the nature of this impaired differentiation. JF - Leukemia AU - Slape, C AU - Chung, Y J AU - Soloway, P D AU - Tessarollo, L AU - Aplan, P D AD - Genetics Branch, National Cancer Institute, National Institutes of Health, Navy 8, Room 5101, 8901 Wisconsin Avenue, Bethesda, MD 20889, USA, aplanp@mail.nih.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1239 EP - 1248 VL - 21 IS - 6 SN - 0887-6924, 0887-6924 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Transformation KW - Chronic myeloid leukemia KW - Acute myeloid leukemia KW - Interleukin 3 KW - Animal models KW - Immunodeficiency KW - Cell culture KW - Macrophage colony-stimulating factor KW - Granulocyte colony-stimulating factor KW - BCR protein KW - Gene expression KW - Differentiation KW - Promoters KW - Stem cells KW - Colonies KW - Complementation KW - Embryo cells KW - Blast crisis KW - Cytology KW - Abl protein KW - Tumorigenicity KW - Tumors KW - Myelodysplastic syndrome KW - Erythropoietin KW - Gene fusion KW - Liquid culture KW - Hemopoiesis KW - Fusion protein KW - G 07870:Mammals KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19861242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia&rft.atitle=Mouse+embryonic+stem+cells+that+express+a+NUP98-HOXD13+fusion+protein+are+impaired+in+their+ability+to+differentiate+and+can+be+complemented+by+BCR-ABL&rft.au=Slape%2C+C%3BChung%2C+Y+J%3BSoloway%2C+P+D%3BTessarollo%2C+L%3BAplan%2C+P+D&rft.aulast=Slape&rft.aufirst=C&rft.date=2007-06-01&rft.volume=21&rft.issue=6&rft.spage=1239&rft.isbn=&rft.btitle=&rft.title=Leukemia&rft.issn=08876924&rft_id=info:doi/10.1038%2Fsj.leu.2404648 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Chronic myeloid leukemia; Transformation; Interleukin 3; Acute myeloid leukemia; Immunodeficiency; Animal models; Cell culture; Granulocyte colony-stimulating factor; Macrophage colony-stimulating factor; BCR protein; Gene expression; Promoters; Differentiation; Colonies; Stem cells; Complementation; Embryo cells; Blast crisis; Cytology; Abl protein; Tumorigenicity; Tumors; Myelodysplastic syndrome; Erythropoietin; Liquid culture; Gene fusion; Hemopoiesis; Fusion protein DO - http://dx.doi.org/10.1038/sj.leu.2404648 ER - TY - JOUR T1 - Blood Folate Levels and Risk of Liver Damage and Hepatocellular Carcinoma in a Prospective High-Risk Cohort AN - 19854802; 7461226 AB - Background: Studies in experimental animals suggest that low folate levels may play a role in liver damage and hepatocarcinogenesis. To examine this association in humans, folate levels in blood and risk for subsequent liver damage and hepatocellular carcinoma (HCC) were assessed in a population at high risk of liver cancer in China. Methods: Four hundred fifteen hepatitis B surface antigen-positive participants of the Haimen City Cohort were prospectively followed between 1998 and 2002. Serum and RBC folate levels were determined at baseline. Alanine aminotransferase (ALT) and hepatitis B virus DNA levels were measured semiannually. Logistic regression modeling was used to examine the presence of hepatitis B virus DNA and HCC, whereas linear regression with a log-link function was used to examine ALT levels. Results: There was a statistically significant inverse association between serum folate level and ALT level. ALT levels decreased with each quartile increase in serum folate (adjusted odds ratio, 0.86; 95% confidence interval, 0.76-0.97 for the highest compared with the lowest quartile; P sub(trend) = 0.002). After exclusion of three persons with prevalent HCC, 20 (4.9%) of the 412 study participants developed HCC during follow-up, with a median time between enrollment and HCC diagnosis of 2.66 years (interquartile range, 1.8-4.1). When comparing persons in the lowest quartile RBC folate to persons in all other quartiles, the analysis found that higher RBC folate levels were associated with reduced risk of hepatocarcinogenesis (odds ratio, 0.33, 95% confidence interval, 0.13-0.86; P sub(trend) = 0.02). Conclusions: This study suggests that increased folate levels in humans may be inversely associated with the development of liver damage and HCC. (Cancer Epidemiol Biomarkers Prev 2007; 6(6):1279-82) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Welzel, Tania M AU - Katki, Hormuzd A AU - Sakoda, Lori C AU - Evans, Alison A AU - London, WThomas AU - Chen, Gang AU - O'Broin, Sean AU - Shen, Fu-Min AU - Lin, Wen-Yao AU - McGlynn, Katherine A AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1279 EP - 1282 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 6 SN - 1055-9965, 1055-9965 KW - Virology & AIDS Abstracts; Risk Abstracts KW - Bioindicators KW - Hepatitis B virus KW - Liver cancer KW - Statistical analysis KW - hepatitis B KW - Alanine transaminase KW - biomarkers KW - Cancer KW - risk reduction KW - Blood KW - Risk factors KW - Liver KW - prevention KW - DNA KW - Hepatitis B KW - Risk groups KW - China, People's Rep. KW - Folic acid KW - Urban areas KW - Hepatocellular carcinoma KW - R2 23060:Medical and environmental health KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19854802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Blood+Folate+Levels+and+Risk+of+Liver+Damage+and+Hepatocellular+Carcinoma+in+a+Prospective+High-Risk+Cohort&rft.au=Welzel%2C+Tania+M%3BKatki%2C+Hormuzd+A%3BSakoda%2C+Lori+C%3BEvans%2C+Alison+A%3BLondon%2C+WThomas%3BChen%2C+Gang%3BO%27Broin%2C+Sean%3BShen%2C+Fu-Min%3BLin%2C+Wen-Yao%3BMcGlynn%2C+Katherine+A&rft.aulast=Welzel&rft.aufirst=Tania&rft.date=2007-06-01&rft.volume=16&rft.issue=6&rft.spage=1279&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Blood; Liver cancer; Risk factors; Statistical analysis; Hepatitis B; DNA; Risk groups; Alanine transaminase; Folic acid; biomarkers; Hepatocellular carcinoma; Bioindicators; risk reduction; prevention; Liver; hepatitis B; Cancer; Urban areas; Hepatitis B virus; China, People's Rep. ER - TY - JOUR T1 - The DinG Protein from Escherichia coli Is a Structure-specific Helicase AN - 19849436; 7462740 AB - The Escherichia coli DinG protein is a DNA damage-inducible member of the helicase superfamily 2. Using a panel of synthetic substrates, we have systematically investigated structural requirements for DNA unwinding by DinG. We have found that the helicase does not unwind blunt-ended DNAs or substrates with 3'-ss tails. On the other hand, the 5'-ss tails of 11-15 nucleotides are sufficient to initiate DNA duplex unwinding; bifurcated substrates further facilitate helicase activity. DinG is active on 5'-flap structures; however, it is unable to unwind 3'-flaps. Similarly to the homologous Saccharomyces cerevisiae Rad3 helicase, DinG unwinds DNA.RNA duplexes. DinG is active on synthetic D-loops and R-loops. The ability of the enzyme to unwind D-loops formed on superhelical plasmid DNA by the E. coli recombinase RecA suggests that D-loops may be natural substrates for DinG. Although the availability of 5'-ssDNA tails is a strict requirement for duplex unwinding by DinG, the unwinding of D-loops can be initiated on substrates without any ss tails. Since DinG is DNA damage-inducible and is active on D-loops and forked structures, which mimic intermediates of homologous recombination and replication, we conclude that this helicase may be involved in recombinational DNA repair and the resumption of replication after DNA damage. JF - Journal of Biological Chemistry AU - Voloshin, Oleg N AU - Camerini-Otero, RDaniel AD - Genetics and Biochemistry Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 18437 EP - 18447 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 25 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology KW - D-loops KW - Replication KW - Tails KW - Unwinding KW - recombinase KW - Superhelical DNA KW - Enzymes KW - Plasmids KW - DNA repair KW - Nucleotides KW - Saccharomyces cerevisiae KW - DNA damage KW - R-loops KW - Escherichia coli KW - homologous recombination KW - DNA helicase KW - RecA protein KW - J 02330:Biochemistry KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19849436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=The+DinG+Protein+from+Escherichia+coli+Is+a+Structure-specific+Helicase&rft.au=Voloshin%2C+Oleg+N%3BCamerini-Otero%2C+RDaniel&rft.aulast=Voloshin&rft.aufirst=Oleg&rft.date=2007-06-01&rft.volume=282&rft.issue=25&rft.spage=18437&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - D-loops; Unwinding; Tails; Replication; recombinase; Superhelical DNA; Enzymes; DNA repair; Plasmids; Nucleotides; DNA damage; R-loops; homologous recombination; DNA helicase; RecA protein; Escherichia coli; Saccharomyces cerevisiae ER - TY - JOUR T1 - Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates AN - 19785812; 7532541 AB - The Cockayne syndrome B (CSB) protein-defective in a majority of patients suffering from the rare autosomal disorder CS-is a member of the SWI2/SNF2 family with roles in DNA repair and transcription. We demonstrate herein that purified recombinant CSB and the major human apurinic/apyrimidinic (AP) endonuclease, APE1, physically and functionally interact. CSB stimulates the AP site incision activity of APE1 on normal (i.e. fully paired) and bubble AP-DNA substrates, with the latter being more pronounced (up to 6-fold). This activation is ATP-independent, and specific for the human CSB and full-length APE1 protein, as no CSB-dependent stimulation was observed with Escherichia coli endonuclease IV or an N-terminal truncated APE1 fragment. CSB and APE1 were also found in a common protein complex in human cell extracts, and recombinant CSB, when added back to CSB-deficient whole cell extracts, resulted in increased total AP site incision capacity. Moreover, human fibroblasts defective in CSB were found to be hypersensitive to both methyl methanesulfonate (MMS) and 5-hydroxymethyl-2'-deoxyuridine, agents that introduce base excision repair (BER) DNA substrates/intermediates. JF - Nucleic Acids Research AU - Wong, Heng-Kuan AU - Muftuoglu, Meltem AU - Beck, Gad AU - Imam, Syed Z AU - Bohr, Vilhelm A AU - Wilson, David MIII AD - Laboratory of Molecular Gerontology, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224 and South Texas Veterans Health Care System and Departments of Medicine and Pharmacology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 4103 EP - 4113 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 35 IS - 12 SN - 0305-1048, 0305-1048 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Methyl methanesulfonate KW - Ape1 protein KW - Base excision repair KW - Escherichia coli KW - Transcription KW - AP endonuclease KW - Endonuclease KW - Cockayne syndrome KW - DNA repair KW - Fibroblasts KW - J 02310:Genetics & Taxonomy KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19785812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Cockayne+syndrome+B+protein+stimulates+apurinic+endonuclease+1+activity+and+protects+against+agents+that+introduce+base+excision+repair+intermediates&rft.au=Wong%2C+Heng-Kuan%3BMuftuoglu%2C+Meltem%3BBeck%2C+Gad%3BImam%2C+Syed+Z%3BBohr%2C+Vilhelm+A%3BWilson%2C+David+MIII&rft.aulast=Wong&rft.aufirst=Heng-Kuan&rft.date=2007-06-01&rft.volume=35&rft.issue=12&rft.spage=4103&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Methyl methanesulfonate; Ape1 protein; Base excision repair; Transcription; AP endonuclease; DNA repair; Cockayne syndrome; Endonuclease; Fibroblasts; Escherichia coli ER - TY - JOUR T1 - Anatomy of data integration AN - 19723112; 7498861 AB - Producing reliable information is the ultimate goal of data processing. The ocean of data created with the advances of science and technologies calls for integration of data coming from heterogeneous sources that are diverse in their purposes, business rules, underlying models and enabling technologies. Reference models, Semantic Web, standards, ontology, and other technologies enable fast and efficient merging of heterogeneous data, while the reliability of produced information is largely defined by how well the data represent the reality. In this paper, we initiate a framework for assessing the informational value of data that includes data dimensions; aligning data quality with business practices; identifying authoritative sources and integration keys; merging models; uniting updates of varying frequency and overlapping or gapped data sets. JF - Journal of Biomedical Informatics AU - Brazhnik, O AU - Jones, J F AD - National Institutes of Health, 10401 Fernwood Road, Room 3NW03, Bethesda, MD 20817, USA, brazhnik@nih.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 252 EP - 269 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 40 IS - 3 SN - 1532-0464, 1532-0464 KW - Biotechnology and Bioengineering Abstracts KW - Integration KW - Data processing KW - Training KW - Oceans KW - Bioinformatics KW - Models KW - Semantics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19723112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Informatics&rft.atitle=Anatomy+of+data+integration&rft.au=Brazhnik%2C+O%3BJones%2C+J+F&rft.aulast=Brazhnik&rft.aufirst=O&rft.date=2007-06-01&rft.volume=40&rft.issue=3&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Informatics&rft.issn=15320464&rft_id=info:doi/10.1016%2Fj.jbi.2006.09.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Integration; Data processing; Training; Oceans; Bioinformatics; Semantics; Models DO - http://dx.doi.org/10.1016/j.jbi.2006.09.001 ER - TY - JOUR T1 - Retrospective Biodosimetry among United States Radiologic Technologists AN - 19708098; 7767956 AB - Measurement of chromosome translocations in peripheral blood lymphocytes has been used to quantify prior exposure to ionizing radiation, including for workers exposed to low, chronic doses. We assessed translocation frequencies in a subset of U.S. radiologic technologists to substantiate ionizing radiation dose estimates developed for 110,418 technologists who worked between 1916 and 1984. From 3,441 cohort members known to have begun working before 1950, we selected a sample of 152, stratified by estimated cumulative dose, oversampling from higher-dose categories and excluding persons with a prior cancer diagnosis, a personal or family history of chromosomal instability disorders, or a current history of smoking. Estimates of film-badge dose ranged from less than 10 cSv to more than 30 cSv. Blood samples, obtained in 2004, were analyzed by fluorescence in situ hybridization (FISH) whole chromosome painting by simultaneously labeling chromosomes 1, 2 and 4 in red and 3, 5 and 6 in green. Translocations were scored in 1800 well-spread metaphase cells and expressed per 100 cell equivalents (CE) per person. Linear Poisson regression models with allowance for overdispersion were used to assess the relationship between estimated occupational red bone marrow absorbed dose in cGy and translocation frequency, adjusted for age, gender and estimated red bone marrow absorbed dose score from personal diagnostic procedures. We observed 0.09 excess translocations per 100 CE per cGy red bone marrow dose (95% CI: -0.01, 0.2; P = 0.07), which is similar to the expected estimate based on previous cytogenetic studies (0.05 excess translocations per 100 CE per cGy). Despite uncertainty in the estimates of occupational red bone marrow absorbed doses, we found good general agreement between the doses and translocation frequencies, lending support to the credibility of the dose assessment for this large cohort of U.S. radiologic technologists. JF - Radiation Research AU - Bhatti, P AU - Preston, D L AU - Doody, M M AU - Hauptmann, M AU - Kampa, D AU - Alexander, B H AU - Petibone, D AU - Simon, S L AU - Weinstock, R M AU - Bouville, A AU - Yong, L C AU - Freedman, D M AU - Mabuchi, K AU - Linet AU - Edwards, A A AU - Tucker, J D AU - Sigurdson, A J AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 727 EP - 734 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com], [URL:http://www.allenpress.com] VL - 167 IS - 6 SN - 0033-7587, 0033-7587 KW - Health & Safety Science Abstracts KW - Historical account KW - Age KW - Fluorescence KW - Bone marrow KW - Radiation dosimetry KW - Lymphocytes KW - Cancer KW - Genetics KW - Smoking KW - USA KW - Chromosomes KW - Ionizing radiation KW - Gender KW - translocation KW - Occupational exposure KW - H 8000:Radiation Safety/Electrical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19708098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Retrospective+Biodosimetry+among+United+States+Radiologic+Technologists&rft.au=Bhatti%2C+P%3BPreston%2C+D+L%3BDoody%2C+M+M%3BHauptmann%2C+M%3BKampa%2C+D%3BAlexander%2C+B+H%3BPetibone%2C+D%3BSimon%2C+S+L%3BWeinstock%2C+R+M%3BBouville%2C+A%3BYong%2C+L+C%3BFreedman%2C+D+M%3BMabuchi%2C+K%3BLinet%3BEdwards%2C+A+A%3BTucker%2C+J+D%3BSigurdson%2C+A+J&rft.aulast=Bhatti&rft.aufirst=P&rft.date=2007-06-01&rft.volume=167&rft.issue=6&rft.spage=727&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR0894.1 L2 - http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0033-7587&volume=167&issue=6&page=727 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Historical account; Age; Fluorescence; Bone marrow; Radiation dosimetry; Lymphocytes; Cancer; Smoking; Genetics; Chromosomes; Ionizing radiation; Gender; translocation; Occupational exposure; USA DO - http://dx.doi.org/10.1667/RR0894.1 ER - TY - JOUR T1 - Methamphetamine Administration Causes Death of Dopaminergic Neurons in the Mouse Olfactory Bulb AN - 19704694; 7501412 AB - Background Methamphetamine (METH) is an addictive drug that can cause neurological and psychiatric disorders. In the rodent brain, toxic doses of METH cause damage of dopaminergic terminals and apoptosis of nondopaminergic neurons. The olfactory bulb (OB) is a brain region that is rich with dopaminergic neurons and terminals. Methods Rats were given a single injection of METH (40 mg/kg) and sacrificed at various time points afterward. The toxic effects of this injection on the OB were assessed by measuring monoamine levels, tyrosine hydroxylase (TH) immunocytochemistry, terminal deoxynucleotidyl transferase-mediated deoxyribonucleotide triphosphate (dNTP) nick end labeling (TUNEL) histochemistry, and caspase-3 immunochemistry. Results Methamphetamine administration caused marked decreases in dopamine (DA) levels and TH-like immunostaining in the mouse OB. The drug also caused increases in TUNEL-labeled OB neurons, some of which were also positive for TH expression. Moreover, there was METH-induced expression of activated caspase-3 in TH-positive cells. Finally, the METH injection was associated with increased expression of the proapoptotic proteins, Bax and Bid, but with decreased expression of the antideath protein, Bcl2. Conclusions These observations show, for the first time, that METH can cause loss of OB DA terminals and death of DA neurons, in part, via mechanisms that are akin to an apoptotic process. JF - Biological Psychiatry AU - Deng, X AU - Ladenheim, B AU - Jayanthi, S AU - Cadet, J L AD - Molecular Neuropsychiatry Branch, National Institute on Drug Abuse/IRP, 5500 Nathan Shock Drive, Baltimore MD 21224, USA Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1235 EP - 1243 VL - 61 IS - 11 SN - 0006-3223, 0006-3223 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Immunocytochemistry KW - monoamines KW - Apoptosis KW - Neurological diseases KW - Brain KW - Drug abuse KW - deoxyribonucleotides KW - Olfactory bulb KW - Methamphetamine KW - Mental disorders KW - Dopamine KW - Neurons KW - Bax protein KW - Caspase-3 KW - BID protein KW - Drug addiction KW - Immunochemistry KW - Tyrosine 3-monooxygenase KW - Histochemistry KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19704694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+Psychiatry&rft.atitle=Methamphetamine+Administration+Causes+Death+of+Dopaminergic+Neurons+in+the+Mouse+Olfactory+Bulb&rft.au=Deng%2C+X%3BLadenheim%2C+B%3BJayanthi%2C+S%3BCadet%2C+J+L&rft.aulast=Deng&rft.aufirst=X&rft.date=2007-06-01&rft.volume=61&rft.issue=11&rft.spage=1235&rft.isbn=&rft.btitle=&rft.title=Biological+Psychiatry&rft.issn=00063223&rft_id=info:doi/10.1016%2Fj.biopsych.2006.09.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Immunocytochemistry; monoamines; Neurological diseases; Apoptosis; Brain; Drug abuse; Olfactory bulb; deoxyribonucleotides; Mental disorders; Methamphetamine; Dopamine; Bax protein; Neurons; Caspase-3; BID protein; Tyrosine 3-monooxygenase; Immunochemistry; Drug addiction; Histochemistry DO - http://dx.doi.org/10.1016/j.biopsych.2006.09.010 ER - TY - JOUR T1 - Preventing Excessive Weight Gain in Adolescents: Interpersonal Psychotherapy for Binge Eating AN - 19695341; 7464276 AB - The most prevalent disordered eating pattern described in overweight youth is loss of control (LOC) eating, during which individuals experience an inability to control the type or amount of food they consume. LOC eating is associated cross-sectionally with greater adiposity in children and adolescents and seems to predispose youth to gain weight or body fat above that expected during normal growth, thus likely contributing to obesity in susceptible individuals. No prior studies have examined whether LOC eating can be decreased by interventions in children or adolescents without full-syndrome eating disorders or whether programs reducing LOC eating prevent inappropriate weight gain attributable to LOC eating. Interpersonal psychotherapy, a form of therapy that was designed to treat depression and has been adapted for the treatment of eating disorders, has shown efficacy in reducing binge eating episodes and inducing weight stabilization among adults diagnosed with binge eating disorder. In this paper, we propose a theoretical model of excessive weight gain in adolescents at high risk for adult obesity who engage in LOC eating and associated overeating patterns. A rationale is provided for interpersonal psychotherapy as an intervention to slow the trajectory of weight gain in at-risk youth, with the aim of preventing or ameliorating obesity in adulthood. JF - Obesity Research AU - Tanofsky-Kraff, Marian AU - Wilfley, Denise E AU - Young, Jami F AU - Mufson, Laura AU - Yanovski, Susan Z AU - Glasofer, Deborah R AU - Salaita, Christine G AD - Unit on Growth and Obesity, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Department of Health and Human Services, Bethesda, Maryland. Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, Maryland. Weight Management and Eating Disorders Program, Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri. Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York. Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Department of Health and Human Services, Bethesda, Maryland Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1345 EP - 1355 PB - North American Association for the Study of Obesity, 1090 Amsterdam Ave., Ste. 14K New York NY 10025 USA, [mailto:helener@mindspring.com], [URL:http://www.naaso.org] VL - 15 IS - 6 SN - 1071-7323, 1071-7323 KW - Physical Education Index KW - Obesity KW - Programs KW - Depression KW - Eating disorders KW - Adolescence KW - Diet (weight control) KW - Therapy KW - Adults KW - Children KW - Experience KW - Youth KW - Self efficacy KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19695341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obesity+Research&rft.atitle=Preventing+Excessive+Weight+Gain+in+Adolescents%3A+Interpersonal+Psychotherapy+for+Binge+Eating&rft.au=Tanofsky-Kraff%2C+Marian%3BWilfley%2C+Denise+E%3BYoung%2C+Jami+F%3BMufson%2C+Laura%3BYanovski%2C+Susan+Z%3BGlasofer%2C+Deborah+R%3BSalaita%2C+Christine+G&rft.aulast=Tanofsky-Kraff&rft.aufirst=Marian&rft.date=2007-06-01&rft.volume=15&rft.issue=6&rft.spage=1345&rft.isbn=&rft.btitle=&rft.title=Obesity+Research&rft.issn=10717323&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Experience; Obesity; Programs; Depression; Eating disorders; Adolescence; Therapy; Diet (weight control); Adults; Children; Youth; Self efficacy ER - TY - JOUR T1 - Serum and Dietary Vitamin E in Relation to Prostate Cancer Risk AN - 19695237; 7461222 AB - alpha -Tocopherol supplementation (50 mg daily for 5-8 years) reduced prostate cancer incidence by 32% in the alpha -Tocopherol, {szligbeta}-Carotene Cancer Prevention Study. We investigated whether serum alpha -tocopherol or intake of vitamin E (eight tocopherols and tocotrienols) was associated with prostate cancer risk with up to 19 years of follow-up in the alpha -Tocopherol, {szligbeta}-Carotene Cancer Prevention Study cohort. Of the 29,133 Finnish male smokers, ages 50 to 69 years recruited into the study, 1,732 were diagnosed with incident prostate cancer between 1985 and 2004. Baseline serum alpha -tocopherol was measured by high-performance liquid chromatography and the components of vitamin E intake were estimated based on a 276-item food frequency questionnaire and food chemistry analyses. Proportional hazard models were used to determine multivariate-adjusted relative risks (RR) and 95% confidence intervals (95% CI). Higher serum alpha -tocopherol was associated with reduced risk of prostate cancer (RR, 0.80; 95% CI, 0.66-0.96 for highest versus lowest quintile; P sub(trend) = 0.03) and was strongly and inversely related to the risk of developing advanced disease (RR, 0.56; 95% CI, 0.36-0.85; P sub(trend) = 0.002). The inverse serum alpha -tocopherol-prostate cancer association was greater among those who were supplemented with either alpha -tocopherol or {szligbeta}-carotene during the trial. There were no associations between prostate cancer and the individual dietary tocopherols and tocotrienols. In summary, higher prediagnostic serum concentrations of alpha -tocopherol, but not dietary vitamin E, was associated with lower risk of developing prostate cancer, particularly advanced prostate cancer. (Cancer Epidemiol Biomarkers Prev 2007; 16(6):1253-9) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Weinstein, Stephanie J AU - Wright, Margaret E AU - Lawson, Karla A AU - Snyder, Kirk AU - Maennistoe, Satu AU - Taylor, Philip R AU - Virtamo, Jarmo AU - Albanes, Demetrius AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1253 EP - 1259 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 6 SN - 1055-9965, 1055-9965 KW - vitamins KW - Risk Abstracts KW - Diets KW - Bioindicators KW - risk reduction KW - Liquid chromatography KW - prevention KW - prostate cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19695237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Serum+and+Dietary+Vitamin+E+in+Relation+to+Prostate+Cancer+Risk&rft.au=Weinstein%2C+Stephanie+J%3BWright%2C+Margaret+E%3BLawson%2C+Karla+A%3BSnyder%2C+Kirk%3BMaennistoe%2C+Satu%3BTaylor%2C+Philip+R%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius&rft.aulast=Weinstein&rft.aufirst=Stephanie&rft.date=2007-06-01&rft.volume=16&rft.issue=6&rft.spage=1253&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Bioindicators; Diets; risk reduction; Liquid chromatography; prevention; prostate cancer ER - TY - JOUR T1 - Load-dependent mechanism of nonmuscle myosin 2 AN - 19694229; 7464737 AB - Loads on molecular motors regulate and coordinate their function. In a study that directly measures properties of internally strained myosin 2 heads bound to actin, we find that human nonmuscle myosins 2A and 2B show marked load-dependent changes in kinetics of ADP release but not in nucleotide binding. We show that the ADP release rate constant is increased 4-fold by the assisting load on one head and decreased 5-fold (for 2A) or 12-fold (for 2B) by the resisting load on the other. Thus these myosins, especially 2B, have marked mechanosensitivity of product release. By regulating the actin attachment of myosin heads, this provides a basis for energy-efficient tension maintenance without obstructing cellular contractility driven by other motors such as smooth muscle myosin. Whereas forward load accelerates the cycle of interaction with actin, resistive load increases duty ratio to favor tension maintenance by two-headed attachment. JF - Proceedings of the National Academy of Sciences, USA AU - Kovacs, Mihaly AU - Thirumurugan, Kavitha AU - Knight, Peter J AU - Sellers, James R AD - Laboratory of Molecular Physiology, National Heart, Lung, and Blood Institute, Bethesda, MD 20892-8015 Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 9994 EP - 9999 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 24 SN - 0027-8424, 0027-8424 KW - Sustainability Science Abstracts KW - ADP KW - Kinetics KW - Muscles KW - Maintenance KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19694229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Load-dependent+mechanism+of+nonmuscle+myosin+2&rft.au=Kovacs%2C+Mihaly%3BThirumurugan%2C+Kavitha%3BKnight%2C+Peter+J%3BSellers%2C+James+R&rft.aulast=Kovacs&rft.aufirst=Mihaly&rft.date=2007-06-01&rft.volume=104&rft.issue=24&rft.spage=9994&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - ADP; Kinetics; Muscles; Maintenance ER - TY - JOUR T1 - Do Skinfold Measurements Provide Additional Information to Body Mass Index in the Assessment of Body Fatness Among Children and Adolescents? AN - 19693282; 7464420 AB - OBJECTIVES. The purpose of this work was to validate the performance of age- and gender-specific BMI, triceps, and subscapular skinfold for the classification of excess of body fat in children and adolescents and to examine how much additional information these 2 skinfold measurements provide to BMI-for-age. METHODS. The receiver operating characteristic curve was used to characterize the sensitivity and specificity of these 3 indices in classifying excess body fat. Percentage of body fat was determined by dual-energy radiograph absorptiometry. Both greater than or equal to 85th and greater than or equal to 95th percentile of percentage of body fat were used to define excess body fat. Data from the New York Pediatric Rosetta Body Composition Project were examined (n = 1196; aged 5-18 years). RESULTS. For children aged 5 to 18 years, BMI-for-age, triceps skinfold-for-age, and subscapular skinfold-for-age each performed equally well alone in the receiver operating characteristic curves in the identification of excess body fat defined by either the 85th or 95th percentile of percentage of body fat by dual-energy radiograph absorptiometry. However, if BMI-for-age was already known and was >95th percentile, the additional measurement of skinfolds did not significantly increase the sensitivity or specificity in the identification of excess body fat. CONCLUSIONS. In contrast to the recommendations of expert panels, skinfold measurements do not seem to provide additional information about excess body fat beyond BMI-for-age alone if the BMI-for-age is >95th percentile. JF - Pediatrics AU - Mei, Zuguo AU - Grummer-Strawn, Laurence M AU - Wang, Jack AU - Thornton, John C AU - Freedman, David S AU - Pierson, Richard NJr AU - Dietz, William H AU - Horlick, Mary AD - Division of Nutrition and Physical Activity, Centers for Disease Control and Prevention, Atlanta, Georgia. Body Composition Unit, Department of Medicine, Obesity Research Center, St Luke's-Roosevelt Hospital, New York, New York. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - e1306 EP - e1313 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 119 IS - 6 SN - 0031-4005, 0031-4005 KW - Physical Education Index KW - Evaluation KW - Measurement KW - Specificity KW - Classification KW - Pediatrics KW - Adolescence KW - Body mass KW - Work KW - Performance KW - Children KW - Body composition KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19693282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Do+Skinfold+Measurements+Provide+Additional+Information+to+Body+Mass+Index+in+the+Assessment+of+Body+Fatness+Among+Children+and+Adolescents%3F&rft.au=Mei%2C+Zuguo%3BGrummer-Strawn%2C+Laurence+M%3BWang%2C+Jack%3BThornton%2C+John+C%3BFreedman%2C+David+S%3BPierson%2C+Richard+NJr%3BDietz%2C+William+H%3BHorlick%2C+Mary&rft.aulast=Mei&rft.aufirst=Zuguo&rft.date=2007-06-01&rft.volume=119&rft.issue=6&rft.spage=e1306&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Evaluation; Measurement; Classification; Specificity; Pediatrics; Body mass; Adolescence; Work; Performance; Body composition; Children ER - TY - JOUR T1 - Transactivation of the Epidermal Growth Factor Receptor by Formylpeptide Receptor Exacerbates the Malignant Behavior of Human Glioblastoma Cells AN - 19692671; 7461114 AB - The G protein-coupled formylpeptide receptor (FPR), which mediates leukocyte migration in response to bacterial and host-derived chemotactic peptides, promotes the chemotaxis, survival, and tumorigenesis of highly malignant human glioblastoma cells. Because glioblastoma cells may also express other receptors for growth signals, such as the epidermal growth factor (EGF) receptor (EGFR), we investigated the role of EGFR in the signaling cascade of FPR and how two receptors cross-talk to exacerbate tumor growth. We found that N-formyl-methionyl-leucyl-phenylalanine, an FPR agonist peptide, rapidly induced EGFR phosphorylation at tyrosine residue (Tyr) 992, but not residues 846, 1068, or 1173, in glioblastoma cells, whereas all these residues were phosphorylated after only EGF treatment. The FPR agonist-induced EGFR phosphorylation in tumor cells was dependent on the presence of FPR as well as G alpha i proteins, and was controlled by Src tyrosine kinase. The transactivation of EGFR contributes to the biological function of FPR in glioblastoma cells because inhibition of EGFR phosphorylation significantly reduced FPR agonist-induced tumor cell chemotaxis and proliferation. Furthermore, depletion of both FPR and EGFR by short interference RNA abolished the tumorigenesis of the glioblastoma cells. Our study indicates that the glioblastoma-promoting activity of FPR is mediated in part by transactivation of EGFR and the cross-talk between two receptors exacerbates the malignant phenotype of tumor cells. Thus, targeting both receptors may yield antiglioblastoma agents superior to those targeting one of them. [Cancer Res 2007; 67(12):5906-13] JF - Cancer Research AU - Huang, Jian AU - Hu, Jinyue AU - Bian, Xiuwu AU - Chen, Keqiang AU - Gong, Wanghua AU - Dunlop, Nancy M AU - Howard, OMZack AU - Wang, Ji Ming AD - Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research and Basic Research Program, Science Applications International Corporation-Frederick, National Cancer Institute at Frederick, Frederick, Maryland Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 5906 EP - 5913 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 67 IS - 12 SN - 0008-5472, 0008-5472 KW - Microbiology Abstracts B: Bacteriology; Oncogenes & Growth Factors Abstracts; CSA Neurosciences Abstracts KW - Cell survival KW - formyl peptides KW - Formyl peptides KW - glioblastoma cells KW - Tumorigenesis KW - Tyrosine KW - Epidermal growth factor receptors KW - Chemotaxis KW - Tumor cells KW - Cancer KW - Leukocyte migration KW - Phosphorylation KW - Protein-tyrosine kinase KW - Src protein KW - RNA-mediated interference KW - Epidermal growth factor KW - Cell proliferation KW - Signal transduction KW - B 26600:Tyrosine Kinase Activity KW - J 02320:Cell Biology KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19692671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Transactivation+of+the+Epidermal+Growth+Factor+Receptor+by+Formylpeptide+Receptor+Exacerbates+the+Malignant+Behavior+of+Human+Glioblastoma+Cells&rft.au=Huang%2C+Jian%3BHu%2C+Jinyue%3BBian%2C+Xiuwu%3BChen%2C+Keqiang%3BGong%2C+Wanghua%3BDunlop%2C+Nancy+M%3BHoward%2C+OMZack%3BWang%2C+Ji+Ming&rft.aulast=Huang&rft.aufirst=Jian&rft.date=2007-06-01&rft.volume=67&rft.issue=12&rft.spage=5906&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell survival; formyl peptides; glioblastoma cells; Formyl peptides; Tumorigenesis; Tyrosine; Epidermal growth factor receptors; Tumor cells; Chemotaxis; Cancer; Leukocyte migration; Phosphorylation; Protein-tyrosine kinase; Src protein; RNA-mediated interference; Cell proliferation; Epidermal growth factor; Signal transduction ER - TY - JOUR T1 - Stability of Characters and Construction of Phylogenetic Trees AN - 19690970; 7484895 AB - Parsimony methods infer phylogenetic trees by minimizing number of character changes required to explain observed character states. From the perspective of applicability of parsimony methods, it is important to assess whether the characters used to infer phylogeny are likely to provide a correct tree. We introduce a graph theoretical characterization that helps to assess whether given set of characters is appropriate to use with parsimony methods. Given a set of characters and a set of taxa, we construct a network called character overlap graph. We show that the character overlap graph for characters that are appropriate to use in parsimony methods is characterized by significant under-representation of subnetworks known as holes, and provide a validation for this observation. This characterization explains success in constructing evolutionary trees using parsimony method for some characters (e.g., protein domains) and lack of such success for other characters (e.g., introns). In the latter case, the understanding of obstacles to applying parsimony methods in a direct way has lead us to a new approach for detecting inconsistent and/or noisy data. Namely, we introduce the concept of stable characters which is similar but less restrictive than the well known concept of pairwise compatible characters. Application of this approach to introns produces the evolutionary tree consistent with the Coelomata hypothesis. JF - Journal of Computational Biology AU - Przytycka, T AD - National Center for Biotechnology Information, U.S. National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, przytyck@mail.nih.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 539 EP - 549 VL - 14 IS - 5 SN - 1066-5277, 1066-5277 KW - Biotechnology and Bioengineering Abstracts KW - Phylogeny KW - Data processing KW - Coelomata KW - Introns KW - Computer applications KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19690970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Computational+Biology&rft.atitle=Stability+of+Characters+and+Construction+of+Phylogenetic+Trees&rft.au=Przytycka%2C+T&rft.aulast=Przytycka&rft.aufirst=T&rft.date=2007-06-01&rft.volume=14&rft.issue=5&rft.spage=539&rft.isbn=&rft.btitle=&rft.title=Journal+of+Computational+Biology&rft.issn=10665277&rft_id=info:doi/10.1089%2Fcmb.2007.R001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Phylogeny; Data processing; Introns; Computer applications; Coelomata DO - http://dx.doi.org/10.1089/cmb.2007.R001 ER - TY - JOUR T1 - Birth Weight, Postnatal Growth, and Risk for High Blood Pressure at 7 Years of Age: Results From the Collaborative Perinatal Project AN - 19687763; 7464414 AB - OBJECTIVE. A physiologic predisposition toward hypertension is theorized to result from the combination of intrauterine growth restriction followed by rapid catch-up growth. The objective of this study was to evaluate the effects of birth weight and weight gain during childhood on the risk for high blood pressure in childhood and to identify discrete periods of catch-up growth that put children with intrauterine growth restriction at increased risk for the development of high blood pressure later in life. METHODS. The US Collaborative Perinatal Project (1959-1974) studied 55908 pregnancies in an observational cohort at 12 medical centers in the United States and followed the offspring through 7 years of age. All white or black children who were born at term and completed the follow-up without kidney or heart disease were included in this posthoc analysis. z scores were calculated for weight at birth, 4 months, 1 year, 4 years, and 7 years on the basis of study means and SD. Changes in z scores were calculated for each interval. RESULTS. Each 1-kg increase in birth weight increased the odds for high systolic blood pressure by 2.19 and high diastolic blood pressure by 1.82 when race and change in weight z scores were also included in the regression model. An increase in weight z score of 1 SD above the previous weight z score increased the odds for high systolic blood pressure at 7 years by 1.65 (birth to 4 months), 1.79 (4 months to 1 year), 1.71 (1-4 years), and 1.94 (4-7 years) in the full model. White race increased the odds for high systolic blood pressure by 1.51. CONCLUSIONS. In this large biracial US cohort, infants who were small for gestational age were not at increased risk for high blood pressure at 7 years of age. However, children who crossed weight percentiles upward during early childhood did demonstrate an increased risk. JF - Pediatrics AU - Hemachandra, Anusha H AU - Howards, Penelope P AU - Furth, Susan L AU - Klebanoff, Mark A AD - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland. Divisions of Neonatology. Pediatric Nephrology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland. Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - e1264 EP - e1270 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 119 IS - 6 SN - 0031-4005, 0031-4005 KW - Risk Abstracts KW - USA KW - Growth KW - Age KW - low-birth-weight KW - hypertension KW - Kidney KW - birth weight KW - Children KW - offspring KW - Infants KW - Pregnancy KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19687763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Birth+Weight%2C+Postnatal+Growth%2C+and+Risk+for+High+Blood+Pressure+at+7+Years+of+Age%3A+Results+From+the+Collaborative+Perinatal+Project&rft.au=Hemachandra%2C+Anusha+H%3BHowards%2C+Penelope+P%3BFurth%2C+Susan+L%3BKlebanoff%2C+Mark+A&rft.aulast=Hemachandra&rft.aufirst=Anusha&rft.date=2007-06-01&rft.volume=119&rft.issue=6&rft.spage=e1264&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Age; Growth; hypertension; low-birth-weight; Kidney; birth weight; Children; Pregnancy; Infants; offspring; USA ER - TY - JOUR T1 - Comparison of Proliferative and Multilineage Differentiation Potential of Human Mesenchymal Stem Cells Derived from Umbilical Cord and Bone Marrow AN - 19687284; 7465189 AB - Human umbilical cord perivascular cells (HUCPVCs) have been shown to have a high proliferative potential and the capacity to differentiate into an osteogenic phenotype. HUCPVCs have thus been considered a possible extra-embryonic mesenchymal stem cell (MSC) source for cell-based therapies. To assess this potential, we compared HUCPVCs to the "gold standard" bone marrow mesenchymal stromal cells (BMSCs) with respect to their proliferation, differentiation, and transfection capacities. HUCPVCs showed a higher proliferative potential than BMSCs and were capable of osteogenic, chondrogenic, and adipogenic differentiation. Interestingly, osteogenic differentiation of HUCPVCs proceeded more rapidly than BMSCs. Additionally, HUCPVCs expressed higher levels of CD146, a putative MSC marker, relative to BMSCs. HUCPVCs showed comparable transfection efficiency as BMSCs using a nucleofection method but were more amenable to transfection with liposomal methods (FuGENE). Gene array analysis showed that HUCPVCs also expressed Wnt signaling pathway genes that have been implicated in the regulation of MSCs. The similar characteristics between HUCPVCs and MSCs support the applicability of HUCPVCs for cell-based therapies. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Baksh, Dolores AU - Yao, Raphael AU - Tuan, Rocky S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1384 EP - 1392 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 25 IS - 6 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts KW - Differentiation KW - Stem cells KW - Wnt protein KW - stromal cells KW - Transfection KW - Bone marrow KW - Mesenchyme KW - Cell proliferation KW - Umbilical cord KW - Signal transduction KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19687284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Comparison+of+Proliferative+and+Multilineage+Differentiation+Potential+of+Human+Mesenchymal+Stem+Cells+Derived+from+Umbilical+Cord+and+Bone+Marrow&rft.au=Baksh%2C+Dolores%3BYao%2C+Raphael%3BTuan%2C+Rocky+S&rft.aulast=Baksh&rft.aufirst=Dolores&rft.date=2007-06-01&rft.volume=25&rft.issue=6&rft.spage=1384&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Differentiation; Stem cells; Wnt protein; stromal cells; Transfection; Bone marrow; Cell proliferation; Mesenchyme; Umbilical cord; Signal transduction ER - TY - JOUR T1 - A Prospective Study of Tobacco, Alcohol, and the Risk of Esophageal and Gastric Cancer Subtypes AN - 19686292; 7460149 AB - Rates of esophageal adenocarcinoma and gastric cardia adenocarcinoma have increased, while rates of esophageal squamous cell carcinoma (ESCC) and gastric noncardia adenocarcinoma have decreased, suggesting distinct etiologies. The authors prospectively investigated the associations of alcohol and tobacco with these cancers in 474,606 US participants using Cox models adjusted for potential confounders. Between 1995/1996 and 2000, 97 incident cases of ESCC, 205 of esophageal adenocarcinoma, 188 of gastric cardia, and 187 of gastric noncardia cancer occurred. Compared with nonsmokers, current smokers were at increased risk for ESCC (hazard ratio (HR) = 9.27, 95% confidence interval (CI): 4.04, 21.29), esophageal adenocarcinoma (HR = 3.70, 95% CI: 2.20, 6.22), gastric cardia (HR = 2.86, 95% CI: 1.73, 4.70), and gastric noncardia (HR = 2.04, 95% CI: 1.32, 3.16). Assuming causality, ever smoking had population attributable risks of 77% (95% CI: 0.55, 0.89) for ESCC, 58% (95% CI: 0.38, 0.72) for esophageal adenocarcinoma, 47% (95% CI: 0.27, 0.63) for gastric cardia, and 19% (95% CI: 0.00, 0.37) for gastric noncardia. For drinkers of more than three alcoholic beverages per day, compared with those whose intake was up to one drink per day, the authors found significant associations between alcohol intake and ESCC risk (HR = 4.93, 95% CI: 2.69, 9.03) but not risk for esophageal, gastric cardia, or gastric noncardia adenocarcinoma. JF - American Journal of Epidemiology AU - Freedman, Neal D AU - Abnet, Christian C AU - Leitzmann, Michael F AU - Mouw, Traci AU - Subar, Amy F AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AD - Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1424 EP - 1433 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 165 IS - 12 SN - 0002-9262, 0002-9262 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Alcohol KW - Smoking KW - Etiology KW - Tobacco KW - Cancer KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19686292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=A+Prospective+Study+of+Tobacco%2C+Alcohol%2C+and+the+Risk+of+Esophageal+and+Gastric+Cancer+Subtypes&rft.au=Freedman%2C+Neal+D%3BAbnet%2C+Christian+C%3BLeitzmann%2C+Michael+F%3BMouw%2C+Traci%3BSubar%2C+Amy+F%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur&rft.aulast=Freedman&rft.aufirst=Neal&rft.date=2007-06-01&rft.volume=165&rft.issue=12&rft.spage=1424&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Smoking; Alcohol; Etiology; Tobacco; Cancer ER - TY - JOUR T1 - A Novel Class of Amphipathic DNA Polymers Inhibits Hepatitis C Virus Infection by Blocking Viral Entry AN - 19681734; 7429525 JF - Antiviral Research AU - Matsumura, T AU - Kato, T AU - Hu, Z AU - Juteau, J M AU - Vaillant, A AU - Liang, J AD - NIDDK, NIH, Bethesda, MD, USA Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 74 IS - 3 SN - 0166-3542, 0166-3542 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Hepatitis C virus KW - DNA KW - Infection KW - V 22340:Antiviral Agents KW - W 30915:Pharmaceuticals & Vaccines KW - N 14845:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19681734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+Research&rft.atitle=A+Novel+Class+of+Amphipathic+DNA+Polymers+Inhibits+Hepatitis+C+Virus+Infection+by+Blocking+Viral+Entry&rft.au=Matsumura%2C+T%3BKato%2C+T%3BHu%2C+Z%3BJuteau%2C+J+M%3BVaillant%2C+A%3BLiang%2C+J&rft.aulast=Matsumura&rft.aufirst=T&rft.date=2007-06-01&rft.volume=74&rft.issue=3&rft.spage=A60&rft.isbn=&rft.btitle=&rft.title=Antiviral+Research&rft.issn=01663542&rft_id=info:doi/10.1016%2Fj.antiviral.2007.01.089 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Hepatitis C virus; Infection; DNA DO - http://dx.doi.org/10.1016/j.antiviral.2007.01.089 ER - TY - JOUR T1 - Transcription Antitermination by Translation Initiation Factor IF1 AN - 19673010; 7418428 AB - Bacterial translation initiation factor IF1 is an S1 domain protein that belongs to the oligomer binding (OB) fold proteins. Cold shock domain (CSD)-containing proteins such as CspA (the major cold shock protein of Escherichia coli) and its homologues also belong to the OB fold protein family. The striking structural similarity between IF1 and CspA homologues suggests a functional overlap between these proteins. Certain members of the CspA family of cold shock proteins act as nucleic acid chaperones: they melt secondary structures in nucleic acids and act as transcription antiterminators. This activity may help the cell to acclimatize to low temperatures, since cold-induced stabilization of secondary structures in nascent RNA can impede transcription elongation. Here we show that the E. coli translation initiation factor, IF1, also has RNA chaperone activity and acts as a transcription antiterminator in vivo and in vitro. We further show that the RNA chaperone activity of IF1, although critical for transcription antitermination, is not essential for its role in supporting cell growth, which presumably functions in translation. The results thus indicate that IF1 may participate in transcription regulation and that cross talk and/or functional overlap may exist between the Csp family proteins, known to be involved in transcription regulation at cold shock, and S1 domain proteins, known to function in translation. JF - Journal of Bacteriology AU - Phadtare, Sangita AU - Kazakov, Teymur AU - Bubunenko, Mikhail AU - Court, Donald L AU - Pestova, Tatyana AU - Severinov, Konstantin AD - Department of Biochemistry, Robert Wood Johnson Medical School, 675 Hoes Lane. Waksman Institute, Department of Biochemistry and Molecular Biology, Rutgers, The State University of New Jersey, 190 Frelinghuysen Road, Piscataway, New Jersey 08854. Basic Research Program, SAIC-Frederick, Inc. Molecular Control and Genetics Section, Gene Regulation and Chromosome Biology Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702. Department of Microbiology and Immunology, SUNY Downstate Medical Center, Brooklyn, New York 11203 Y1 - 2007/06/01/ PY - 2007 DA - 2007 Jun 01 SP - 4087 EP - 4093 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 189 IS - 11 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Temperature effects KW - Translation initiation KW - Secondary structure KW - protein families KW - Protein structure KW - transcription antitermination KW - nucleic acids KW - RNA KW - Protein folding KW - Transcription elongation KW - Gene regulation KW - Escherichia coli KW - Cold shock proteins KW - Chaperones KW - J 02310:Genetics & Taxonomy KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19673010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Transcription+Antitermination+by+Translation+Initiation+Factor+IF1&rft.au=Phadtare%2C+Sangita%3BKazakov%2C+Teymur%3BBubunenko%2C+Mikhail%3BCourt%2C+Donald+L%3BPestova%2C+Tatyana%3BSeverinov%2C+Konstantin&rft.aulast=Phadtare&rft.aufirst=Sangita&rft.date=2007-06-01&rft.volume=189&rft.issue=11&rft.spage=4087&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Temperature effects; Translation initiation; Secondary structure; protein families; Protein structure; transcription antitermination; nucleic acids; Protein folding; RNA; Transcription elongation; Gene regulation; Cold shock proteins; Chaperones; Escherichia coli ER - TY - JOUR T1 - Molybdenum cofactor-dependent resistance to N-hydroxylated base analogs in Escherichia coli is independent of MobA function AN - 19669284; 7430861 AB - Lack of molybdenum cofactor (MoCo) in Escherichia coli and related microorganisms was found to cause hypersensitivity to certain N-hydroxylated base analogs, such as HAP (6-N-hydroxylaminopurine). This observation has lead to a previous proposal that E. coli contains a molybdoenzyme capable of detoxifying such N-hydroxylated analogs. Here, we show that, unexpectedly, deletion of all known or putative molybdoenzymes in E. coli failed to reveal any base-analog sensitivity, suggesting that a novel type of MoCo-dependent activity is involved. Further, we establish that protection against the analogs does not require the common molybdopterin guanine-dinucleotide (MGD) form of the cofactor, but instead the guanosine monophosphate (GMP)-free version of MoCo (MPT) is sufficient. JF - Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis AU - Kozmin, S G AU - Schaaper, R M AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA, schaaper@niehs.nih.gov Y1 - 2007/06/01/ PY - 2007 DA - 2007 Jun 01 SP - 9 EP - 15 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 619 IS - 1-2 SN - 1386-1964, 1386-1964 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Molecular modelling KW - Deletion KW - Hypersensitivity KW - Gene deletion KW - Cofactors KW - Molybdenum KW - Escherichia coli KW - Microorganisms KW - Guanosine KW - molybdopterin KW - Mutagenesis KW - J 02310:Genetics & Taxonomy KW - X 24310:Pharmaceuticals KW - A 01490:Miscellaneous KW - N 14845:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19669284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research-Fundamental+and+Molecular+Mechanisms+of+Mutagenesis&rft.atitle=Molybdenum+cofactor-dependent+resistance+to+N-hydroxylated+base+analogs+in+Escherichia+coli+is+independent+of+MobA+function&rft.au=Kozmin%2C+S+G%3BSchaaper%2C+R+M&rft.aulast=Kozmin&rft.aufirst=S&rft.date=2007-06-01&rft.volume=619&rft.issue=1-2&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Mutation+Research-Fundamental+and+Molecular+Mechanisms+of+Mutagenesis&rft.issn=13861964&rft_id=info:doi/10.1016%2Fj.mrfmmm.2006.12.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Gene deletion; Hypersensitivity; Deletion; Cofactors; Molybdenum; Microorganisms; Guanosine; molybdopterin; Mutagenesis; Escherichia coli DO - http://dx.doi.org/10.1016/j.mrfmmm.2006.12.005 ER - TY - JOUR T1 - Probing the folding intermediate of Rd-apocyt b@@d562@ by protein engineering and infrared T-jump AN - 19667851; 7421419 AB - Small proteins often fold in an apparent two-state manner with the absence of detectable early-folding intermediates. Recently, using native-state hydrogen exchange, intermediates that exist after the rate-limiting transition state have been identified for several proteins. However, little is known about the folding kinetics from these post-transition intermediates to their corresponding native states. Herein, we have used protein engineering and a laser-induced temperature-jump (T-jump) technique to investigate this issue and have applied it to Rd-apocyt b@@d562@ , a four-helix bundle protein. Previously, it has been shown that Rd-apocyt b@@d562@ folds via an on-pathway hidden intermediate, which has only the N-terminal helix unfolded. In the present study, a double mutation (V16G/I17A) in the N-terminal helix of Rd-apocyt b@@d562@ was made to further increase the relative population of this intermediate state at high temperature by selectively destabilizing the native state. In the circular dichroism thermal melting experiment, this mutant showed apparent two-state folding behavior. However, in the T-jump experiment, two kinetic phases were observed. Therefore, these results are in agreement with the idea that a folding intermediate is populated on the folding pathway of Rd-apocyt b@@d562@ . Moreover, it was found that the exponential growth rate of the native state from this intermediate state is roughly (25 ^ksec)@@u-1@ at 65^'C. JF - Protein Science AU - Wang, Ting AU - Zhou, Zheng AU - Bunagan, Michelle R AU - Du, Deguo AU - Bai, Yawen AU - Gai, Feng AD - Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1176 EP - 1183 PB - Cold Spring Harbor Laboratory Press, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 16 IS - 6 SN - 0961-8368, 0961-8368 KW - Biotechnology and Bioengineering Abstracts KW - Growth rate KW - Temperature effects KW - Melting KW - Hydrogen exchange KW - Protein folding KW - Protein engineering KW - C.D. KW - Kinetics KW - Mutation KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19667851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Science&rft.atitle=Probing+the+folding+intermediate+of+Rd-apocyt+b%40%40d562%40+by+protein+engineering+and+infrared+T-jump&rft.au=Wang%2C+Ting%3BZhou%2C+Zheng%3BBunagan%2C+Michelle+R%3BDu%2C+Deguo%3BBai%2C+Yawen%3BGai%2C+Feng&rft.aulast=Wang&rft.aufirst=Ting&rft.date=2007-06-01&rft.volume=16&rft.issue=6&rft.spage=1176&rft.isbn=&rft.btitle=&rft.title=Protein+Science&rft.issn=09618368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Protein engineering; Protein folding; Kinetics; Melting; Temperature effects; Growth rate; Hydrogen exchange; C.D.; Mutation ER - TY - JOUR T1 - Biological and Immunological Characteristics of Lipooligosaccharide-Based Conjugate Vaccines for Serotype C Moraxella catarrhalis AN - 19663490; 7418068 AB - Moraxella catarrhalis is an important bacterial cause of otitis media in children and respiratory tract infections in the elderly. Lipooligosaccharide (LOS), a major surface antigen of this bacterium, is a potential vaccine component against the organism. There are three major LOS serotypes (serotypes A, B, and C) in clinical isolates of M. catarrhalis. Our previous studies demonstrated that serotype A and B LOS-based conjugates were immunogenic in animals and elicited bactericidal antibodies. In this study, LOS from serotype C strain 26404 was isolated, detoxified, and conjugated to tetanus toxoid (TT) or the cross-reactive mutant (CRM) of diphtheria toxin to form detoxified LOS (dLOS)-TT, dLOS-CRM-1, and dLOS-CRM-2 vaccine candidates. The molar ratios (dLOS/protein) of the resulting conjugates were 47:1, 19:1, and 32:1, respectively, while the weight ratios were 0.94, 0.84 and 1.44, respectively. All conjugates were highly immunogenic in both mouse and rabbit models. Three subcutaneous injections of each conjugate formulated with the Ribi adjuvant elicited >700-fold increases in serum anti-LOS immunoglobulin G levels in mice (5 mu g of dLOS) and >2,000-fold increases in rabbits (50 mu g of dLOS). The resulting mouse and rabbit antisera showed complement-mediated bactericidal activity against the homologous strain. In addition, a representative rabbit antiserum showed bactericidal activity against 14 of 18 testable strains, and this bactericidal activity could be 100% inhibited by the serotype C or A LOS but only 30% inhibited by the serotype B LOS. These results indicate that the serotype C LOS-based conjugates can be used as vaccine components for further investigation in humans. JF - Infection and Immunity AU - Yu, Shengqing AU - Gu, Xin-Xing AD - Vaccine Research Section, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland 20850 Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 2974 EP - 2980 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 6 SN - 0019-9567, 0019-9567 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Clinical isolates KW - Serotypes KW - Complement KW - Moraxella catarrhalis KW - Animal models KW - Adjuvants KW - Toxoids KW - Children KW - Infection KW - Tetanus KW - Diphtheria toxin KW - Lipooligosaccharides KW - Respiratory tract diseases KW - Antisera KW - surface antigens KW - Otitis media KW - Geriatrics KW - Immunoglobulin G KW - Proteins KW - Vaccines KW - Bactericidal activity KW - W 30915:Pharmaceuticals & Vaccines KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19663490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Biological+and+Immunological+Characteristics+of+Lipooligosaccharide-Based+Conjugate+Vaccines+for+Serotype+C+Moraxella+catarrhalis&rft.au=Yu%2C+Shengqing%3BGu%2C+Xin-Xing&rft.aulast=Yu&rft.aufirst=Shengqing&rft.date=2007-06-01&rft.volume=75&rft.issue=6&rft.spage=2974&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Serotypes; Complement; Animal models; Toxoids; Adjuvants; Tetanus; Infection; Children; Diphtheria toxin; Lipooligosaccharides; Respiratory tract diseases; Antisera; surface antigens; Otitis media; Immunoglobulin G; Geriatrics; Proteins; Vaccines; Bactericidal activity; Moraxella catarrhalis ER - TY - JOUR T1 - sigma super(E) Regulates and Is Regulated by a Small RNA in Escherichia coli AN - 19660218; 7418445 AB - RybB is a small, Hfq-binding noncoding RNA originally identified in a screen of conserved intergenic regions in Escherichia coli. Fusions of the rybB promoter to lacZ were used to screen plasmid genomic libraries and genomic transposon mutants for regulators of rybB expression. A number of plasmids, including some carrying rybB, negatively regulated the fusion. An insertion in the rep helicase and one upstream of dnaK decreased expression of the fusion. Multicopy suppressors of these insertions led to identification of two plasmids that stimulated the fusion. One contained the gene for the response regulator OmpR; the second contained mipA, encoding a murein hydrolase. The involvement of MipA and OmpR in cell surface synthesis suggested that the rybB promoter might be dependent on sigma super(E). The sequence upstream of the +1 of rybB contains a consensus sigma super(E) promoter. The activity of rybB-lacZ was increased in cells lacking the RseA anti-sigma factor and when sigma super(E) was overproduced from a heterologous promoter. The activity of rybB-lacZ and the detection of RybB were totally abolished in an rpoE-null strain. In vitro, sigma super(E) efficiently transcribes from this promoter. Both a rybB mutation and an hfq mutation significantly increased expression of both rybB-lacZ and rpoE-lacZ fusions, consistent with negative regulation of the sigma super(E) response by RybB and other small RNAs. Based on the plasmid screens, NsrR, a repressor sensitive to nitric oxide, was also found to negatively regulate sigma super(E)-dependent promoters in an RseA-independent fashion. JF - Journal of Bacteriology AU - Thompson, Karl M AU - Rhodius, Virgil A AU - Gottesman, Susan AD - Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892. Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California 94143 Y1 - 2007/06/01/ PY - 2007 DA - 2007 Jun 01 SP - 4243 EP - 4256 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 189 IS - 11 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Cell surface KW - Murein KW - Plasmids KW - hydrolase KW - Transposons KW - Promoters KW - RNA KW - Escherichia coli KW - DnaK protein KW - Conserved sequence KW - Nitric oxide KW - genomics KW - Repressors KW - DNA helicase KW - Mutation KW - J 02310:Genetics & Taxonomy KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19660218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=sigma+super%28E%29+Regulates+and+Is+Regulated+by+a+Small+RNA+in+Escherichia+coli&rft.au=Thompson%2C+Karl+M%3BRhodius%2C+Virgil+A%3BGottesman%2C+Susan&rft.aulast=Thompson&rft.aufirst=Karl&rft.date=2007-06-01&rft.volume=189&rft.issue=11&rft.spage=4243&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell surface; Murein; Plasmids; Transposons; hydrolase; Promoters; RNA; DnaK protein; Conserved sequence; Nitric oxide; genomics; Mutation; DNA helicase; Repressors; Escherichia coli ER - TY - JOUR T1 - Common variants in genes that mediate immunity and risk of multiple myeloma AN - 19521735; 8079427 AB - Multiple myeloma (MM) is a B-cell malignancy characterized by aberrant immune function. Using genomic DNA extracted from 127 MM cases aged 21-84 years and 545 population-based controls, we examined the risk of MM associated with 82 common variants in 45 genes that mediate immunity among women of European American descent. Genotyping was determined using validated and optimized TaqMan assays. We estimated haplotype frequencies from unphased genotype data for 20 of these genes using the expectation-maximization progressive insertion algorithm. Compared with controls, MM risk was positively associated with homozygotes of single loci, IL4R (-28120T, rs2107356) and FCGR2A (-120G, rs1801274) (OR = 1.91, 95% CI 1.08-3.38 and 1.95, 95% CI 1.06-3.60, respectively). For genes in which linkage disequilibrium was observed between multiple loci, MM risk was positively associated with the haplotype block covering part of the LTA*TNF complex (LTA -82C/-90G *TNF -1036C/-487G/-417G, OR = 1.63, 95% CI 1.02-2.16) compared with the most frequently occurring haplotype observed among controls (LTA -82A/-90A *TNF -1036C/-487G/-417G). Our findings provide preliminary evidence that common genetic variants in specific immune-mediated pathways could influence the risk of MM. JF - International Journal of Cancer AU - Brown, Elizabeth E AU - Lan, Qing AU - Zheng, Tongzhang AU - Zhang, Yawei AU - Wang, Sophia S AU - Hoar-Zahm, Shelia AU - Chanock, Stephen J AU - Rothman, Nathaniel AU - Baris, Dalsu AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, elbrown@uab.edu Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 2715 EP - 2722 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 120 IS - 12 SN - 0020-7136, 0020-7136 KW - Genetics Abstracts; Risk Abstracts; Immunology Abstracts KW - Data processing KW - double prime Fc receptors KW - multiple myeloma KW - Lymphocytes B KW - Genotyping KW - Tumor necrosis factor KW - Algorithms KW - haplotypes KW - Immunity KW - Genotypes KW - Interleukin 4 receptors KW - Cancer KW - Homozygotes KW - Linkage disequilibrium KW - Malignancy KW - Multiple myeloma KW - Haplotypes KW - Insertion KW - DNA KW - Immune response KW - genomics KW - G 07720:Immunogenetics KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19521735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Common+variants+in+genes+that+mediate+immunity+and+risk+of+multiple+myeloma&rft.au=Brown%2C+Elizabeth+E%3BLan%2C+Qing%3BZheng%2C+Tongzhang%3BZhang%2C+Yawei%3BWang%2C+Sophia+S%3BHoar-Zahm%2C+Shelia%3BChanock%2C+Stephen+J%3BRothman%2C+Nathaniel%3BBaris%2C+Dalsu&rft.aulast=Brown&rft.aufirst=Elizabeth&rft.date=2007-06-01&rft.volume=120&rft.issue=12&rft.spage=2715&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22618 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; double prime Fc receptors; Lymphocytes B; Tumor necrosis factor; Genotyping; Algorithms; Genotypes; Immunity; Interleukin 4 receptors; Homozygotes; Linkage disequilibrium; Malignancy; Haplotypes; Multiple myeloma; Insertion; genomics; Immune response; multiple myeloma; DNA; haplotypes; Cancer DO - http://dx.doi.org/10.1002/ijc.22618 ER - TY - JOUR T1 - Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists AN - 19518216; 8845521 AB - Investigation of a series of heterobicyclic compounds with essential pharmacophoric features of the metabotropic glutamate receptor 5 (mGluR5) antagonists MPEP and MTEP provided novel structural templates with sub- micromolar affinities at the mGluR5. JF - Bioorganic and Medicinal Chemistry Letters AU - Kulkarni, Santosh S AU - Newman, Amy Hauck AD - Medicinal Chemistry Section, National Institute on Drug Abuse, Intramural Research Program, NIH, DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA, anewman@intra.nida.nih.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 2987 EP - 2991 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 17 IS - 11 SN - 0960-894X, 0960-894X KW - Biotechnology and Bioengineering Abstracts KW - Glutamic acid receptors (metabotropic) KW - Antagonists KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19518216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Discovery+of+heterobicyclic+templates+for+novel+metabotropic+glutamate+receptor+subtype+5+antagonists&rft.au=Kulkarni%2C+Santosh+S%3BNewman%2C+Amy+Hauck&rft.aulast=Kulkarni&rft.aufirst=Santosh&rft.date=2007-06-01&rft.volume=17&rft.issue=11&rft.spage=2987&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2007.03.066 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Glutamic acid receptors (metabotropic); Antagonists DO - http://dx.doi.org/10.1016/j.bmcl.2007.03.066 ER - TY - JOUR T1 - Global Network for Women's and Children's Health Research (U01) AN - 19454092; 7457112 AB - The NICHD invites applications from investigators willing to participate under a cooperative agreement in an ongoing multicenter international research network designed to perform randomized clinical trials of interventions to reduce the major risks to maternal, neonatal, infant, and early childhood health in resource-poor countries. The purpose of this solicitation is to complement the existing Global Network with the addition of research units (RUs) from Africa and India. The objective of this program is to contribute to the resolution of maternal and pediatric health problems by establishing a network of RUs (paired U.S.-based and foreign centers) that will use common protocols to implement randomized clinical trials and thus contribute to the evidence base for sound clinical, programmatic and policy decisions. The network will establish the infrastructure necessary to initiate, implement, and evaluate randomized controlled trials in community settings and health care facilities among pregnant women, newborns, infants, and children to the age of 3 years. JF - Environmental Health Perspectives AU - Wright, L L AD - Center for Research for Mothers and Children, National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 4B05, MSC 7510, Bethesda, MD 20892-7510 USA, wrightl@mail.nih.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 1 VL - 115 IS - 6 SN - 0091-6765, 0091-6765 KW - Risk Abstracts; Health & Safety Science Abstracts KW - health problems KW - Health care KW - intervention KW - Africa KW - Environmental health KW - Females KW - clinical trials KW - Children KW - cooperatives KW - India KW - Infants KW - H 12000:Epidemiology and Public Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19454092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Global+Network+for+Women%27s+and+Children%27s+Health+Research+%28U01%29&rft.au=Wright%2C+L+L&rft.aulast=Wright&rft.aufirst=L&rft.date=2007-06-01&rft.volume=115&rft.issue=6&rft.spage=A316&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - health problems; Health care; intervention; Environmental health; Females; Children; clinical trials; cooperatives; Infants; Africa; India ER - TY - JOUR T1 - Nanotechnology platforms and physiological challenges for cancer therapeutics AN - 19377165; 8767011 AB - Nanotechnology is considered to be an emerging, disruptive technology that will have significant impact in all industrial sectors and across-the-board applications in cancer research. There has been tremendous investment in this area and an explosion of research and development efforts in recent years, particularly in the area of cancer research. At the National Institutes of Health, nanomedicine is one of the priority areas under its Roadmap Initiatives. Moreover, in 2005 the National Cancer Institute alone committed $144.3 million over 5 years for its Alliance for Nanotechnology in Cancer program. Much research and development is progressing in the areas of cancer diagnostics, devices, biosensors, and microfluidics, but this review will focus on therapeutics. Current nanotechnology platforms for cancer therapeutics encompass a vast array of nanomaterials and nanodevices. This review will focus on six of the most prominent and most widely studied: nanoshells, carbon nanotubes, dendrimers, quantum dots, superparamagnetic nanoparticles, and liposomes. All of these nanotechnology platforms can be multifunctional, so they are frequently touted as "smart" or "intelligent." This review will discuss the shared approaches in the design and development of these nanotechnology platforms that bestow such characteristics to the nanoparticles. Finally, the review will raise awareness of the physiological challenges for the application of these therapeutic nanotechnologies, in light of some recent advances in our understanding of tumor biology. JF - Nanomedicine: Nanotechnology, Biology and Medicine AU - Kim, Kelly Y AD - Science and Technology Policy Program, School of Public Policy and Public Administration, George Washington University, Washington, DC, kimke@mail.nih.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 103 EP - 110 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 3 IS - 2 SN - 1549-9634, 1549-9634 KW - Biotechnology and Bioengineering Abstracts KW - Biosensors KW - Microfluidics KW - Carbon KW - Quantum dots KW - Reviews KW - nanotubes KW - Tumors KW - Liposomes KW - nanoparticles KW - Cancer KW - nanotechnology KW - W 30955:Biosensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19377165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanomedicine%3A+Nanotechnology%2C+Biology+and+Medicine&rft.atitle=Nanotechnology+platforms+and+physiological+challenges+for+cancer+therapeutics&rft.au=Kim%2C+Kelly+Y&rft.aulast=Kim&rft.aufirst=Kelly&rft.date=2007-06-01&rft.volume=3&rft.issue=2&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Nanomedicine%3A+Nanotechnology%2C+Biology+and+Medicine&rft.issn=15499634&rft_id=info:doi/10.1016%2Fj.nano.2006.12.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - nanotechnology; Cancer; Reviews; nanoparticles; Carbon; Microfluidics; Quantum dots; Liposomes; nanotubes; Tumors; Biosensors DO - http://dx.doi.org/10.1016/j.nano.2006.12.002 ER - TY - JOUR T1 - User-friendly software for the analysis of brain lesions (ABLe) AN - 19333904; 8688936 AB - We previously developed a software package called ABLe (analysis of brain lesions) which characterizes brain lesions in terms of lesion volume and intersection with cytoarchitecture (e.g. Brodmann areas). Since our previous publication, there have been significant improvements to this software package which utilize methods standard to the neuroimaging community. These features include spatial normalization to the MNI template brain (standard of the international consortium for brain mapping), and use of the volume occupancy Talairach labels (VOTL) and automated anatomical labeling (AAL) atlases for full brain quantification of structures impacted by the lesion. Methods for multi-subject studies including lesion-symptom mapping proposed by Bates et al. have been extended in ABLe to produce an exploratory analysis summarizing correlations between subjects with overlapping lesions and behavioral deficit. A subset of data from an ongoing traumatic head injury study correlating deficit with brain anatomy is used to demonstrate the power of this software package. JF - Computer Methods and Programs in Biomedicine AU - Solomon, Jeffrey AU - Raymont, Vanessa AU - Braun, Allen AU - Butman, John A AU - Grafman, Jordan AD - Medical Numerics, Inc., Germantown, MD, USA, jsolomon@cc.nih.gov Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 245 EP - 254 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo@elsevier.com], [URL:http://www.elsevier.nl] VL - 86 IS - 3 SN - 0169-2607, 0169-2607 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Brain mapping KW - Neuroimaging KW - Data processing KW - Brain injury KW - Head KW - Computer applications KW - Computer programs KW - software KW - Atlases KW - Brodmann's area KW - Brain architecture KW - N3 11002:Computational & theoretical neuroscience KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19333904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computer+Methods+and+Programs+in+Biomedicine&rft.atitle=User-friendly+software+for+the+analysis+of+brain+lesions+%28ABLe%29&rft.au=Solomon%2C+Jeffrey%3BRaymont%2C+Vanessa%3BBraun%2C+Allen%3BButman%2C+John+A%3BGrafman%2C+Jordan&rft.aulast=Solomon&rft.aufirst=Jeffrey&rft.date=2007-06-01&rft.volume=86&rft.issue=3&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Computer+Methods+and+Programs+in+Biomedicine&rft.issn=01692607&rft_id=info:doi/10.1016%2Fj.cmpb.2007.02.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Brain architecture; Brain injury; Computer programs; software; Brain mapping; Atlases; Head; Neuroimaging; Data processing; Brodmann's area; Computer applications DO - http://dx.doi.org/10.1016/j.cmpb.2007.02.006 ER - TY - JOUR T1 - Robust Strategies for Automated AFM Force Curve Analysis--I. Non-adhesive Indentation of Soft, Inhomogeneous Materials AN - 17696621; 7598721 AB - The atomic force microscope (AFM) has found wide applicability as a nanoindentation tool to measure local elastic properties of soft materials. An automated approach to the processing of AFM indentation data, namely, the extraction of Young's modulus, is essential to realizing the high-throughput potential of the instrument as an elasticity probe for typical soft materials that exhibit inhomogeneity at microscopic scales. This paper focuses on Hertzian analysis techniques, which are applicable to linear elastic indentation. We compiled a series of synergistic strategies into an algorithm that overcomes many of the complications that have previously impeded efforts to automate the fitting of contact mechanics models to indentation data. AFM raster data sets containing up to 1024 individual force-displacement curves and macroscopic compression data were obtained from testing polyvinyl alcohol gels of known composition. Local elastic properties of tissue-engineered cartilage were also measured by the AFM. All AFM data sets were processed using customized software based on the algorithm, and the extracted values of Young's modulus were compared to those obtained by macroscopic testing. Accuracy of the technique was verified by the good agreement between values of Young's modulus obtained by AFM and by direct compression of the synthetic gels. Validation of robustness was achieved by successfully fitting the vastly different types of force curves generated from the indentation of tissue-engineered cartilage. For AFM indentation data that are amenable to Hertzian analysis, the method presented here minimizes subjectivity in preprocessing and allows for improved consistency and minimized user intervention. Automated, large-scale analysis of indentation data holds tremendous potential in bioengineering applications, such as high-resolution elasticity mapping of natural and artificial tissues. JF - Journal of Biomechanical Engineering, Transactions of the ASME AU - Lin, D C AU - Dimitriadis, E K AU - Horkay, F AD - Laboratory of Integrative and Medical Biophysics, National Institutes of Health, 9 Memorial Drive, Bldg. 9 Rm. 1E118, Bethesda, MD 20892, USA Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 430 EP - 440 VL - 129 IS - 3 SN - 0148-0731, 0148-0731 KW - Biotechnology and Bioengineering Abstracts KW - Polyvinyl alcohol KW - Gels KW - Computer programs KW - software KW - Data processing KW - Cartilage KW - atomic force microscopy KW - Algorithms KW - Tissue engineering KW - Compression KW - Mechanical properties KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17696621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomechanical+Engineering%2C+Transactions+of+the+ASME&rft.atitle=Robust+Strategies+for+Automated+AFM+Force+Curve+Analysis--I.+Non-adhesive+Indentation+of+Soft%2C+Inhomogeneous+Materials&rft.au=Lin%2C+D+C%3BDimitriadis%2C+E+K%3BHorkay%2C+F&rft.aulast=Lin&rft.aufirst=D&rft.date=2007-06-01&rft.volume=129&rft.issue=3&rft.spage=430&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomechanical+Engineering%2C+Transactions+of+the+ASME&rft.issn=01480731&rft_id=info:doi/10.1115%2F1.2720924 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Mechanical properties; Compression; Tissue engineering; Algorithms; Cartilage; Gels; atomic force microscopy; Data processing; Computer programs; software; Polyvinyl alcohol DO - http://dx.doi.org/10.1115/1.2720924 ER - TY - JOUR T1 - A Validated Liquid Chromatography-Atmospheric Pressure Chemical Ionization-Tandem Mass Spectrometric Method for the Quantification of Methadone, 2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), and 2-Ethyl-5-methyl-3,3-diphenylpyroline (EMDP) in Human Breast Milk AN - 1093452313; 17185796 AB - This manuscript details a validated liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry (LC-APCI-MS-MS) method for the quantification of methadone and its metabolites 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and 2-ethyl-5-methyl-3,3-diphenylpyroline (EMDP) in 0.5 mL human breast milk. Limits of detection were 5 ng/mL for methadone and EDDP, and 10 ng/mL for EMDP. Linearity ranged from 10 to 500 ng/mL for all analytes. Breast milk is a complex biological fluid, necessitating several specimen preparation steps to separate methadone and metabolites from the lipophilic matrix. Recoveries were 66-97% following protein precipitation and solid-phase extraction with minimal matrix effect. Acceptable accuracy (89-101%) and precision (15-20% RSD) were achieved for all analytes. This is the first LC-APCI-MS-MS method for the sensitive and specific detection of methadone, EDDP, and EMDP in human breast milk. The method proved suitable for quantification of methadone and metabolites in breast milk of methadone-maintained opiate-dependent women. JF - Journal of Analytical Toxicology AU - Choo, Robin E AU - Jansson, Lauren M AU - Scheidweiler, Karl AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institute of Health, Baltimore, Maryland; and University of Pittsburgh at Titusville, Titusville, Pennsylvania Y1 - 2007/06// PY - 2007 DA - Jun 2007 SP - 265 EP - 269 PB - Preston Publications, Inc., 6600 W. Touhy Ave. Niles IL 60714 United States VL - 31 IS - 5 SN - 0146-4760, 0146-4760 KW - Toxicology Abstracts KW - Breast milk KW - Lipophilic KW - Mass spectroscopy KW - Metabolites KW - Methadone KW - Precipitation KW - Pressure KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1093452313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Analytical+Toxicology&rft.atitle=A+Validated+Liquid+Chromatography-Atmospheric+Pressure+Chemical+Ionization-Tandem+Mass+Spectrometric+Method+for+the+Quantification+of+Methadone%2C+2-Ethylidene-1%2C5-dimethyl-3%2C3-diphenylpyrrolidine+%28EDDP%29%2C+and+2-Ethyl-5-methyl-3%2C3-diphenylpyroline+%28EMDP%29+in+Human+Breast+Milk&rft.au=Choo%2C+Robin+E%3BJansson%2C+Lauren+M%3BScheidweiler%2C+Karl%3BHuestis%2C+Marilyn+A&rft.aulast=Choo&rft.aufirst=Robin&rft.date=2007-06-01&rft.volume=31&rft.issue=5&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Journal+of+Analytical+Toxicology&rft.issn=01464760&rft_id=info:doi/ L2 - http://www.ingentaconnect.com/content/oup/jat/2007/00000031/00000005/art00003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-10-01 N1 - Last updated - 2012-12-03 N1 - SubjectsTermNotLitGenreText - Methadone; Breast milk; Metabolites; Precipitation; Pressure; Lipophilic; Mass spectroscopy ER - TY - JOUR T1 - Oral pirfenidone in patients with chronic fibrosis resulting from radiotherapy: a pilot study. AN - 734209010; 17540023 AB - Fibrosis is a common side effect after treatment with ionizing radiation. Several methods to ameliorate debilitating fibrosis have been employed but without consistent results. The goal of this pilot study is to determine if Pirfenidone, a novel regulator of cytokine gene expression, has the potential to ameliorate established radiation-induced fibrosis. Open label, prospective pilot study of 800 mg three times/day, orally administered Pirfenidone was administered to enrolled patients who were had completed radiation therapy and who had established radiation-induced fibrosis. Range of motion (ROM) was assessed using standard measures, and subjective measures of pain, fatigue, disability and global health were measured every three months. Seven patients were enrolled of whom 3 had ROM assessments of 1 site and 2 had ROM assessments of 2 sites. Of these assessments, 6 revealed increased ROM during drug intervention while 1 revealed a decreased ROM. There was an overall improvement in the mental composite score of the SF36 while physical composite score was decreased and the vitality score was unchanged. Two patients were removed from the study because of syncopal episodes. Several patients experienced improved function of at least 25% and reported subjective improvement. Pirfenidone may benefit patients with radiation-induced fibrosis and is worthy of a larger well controlled trial. JF - Radiation oncology (London, England) AU - Simone, Nicole L AU - Soule, Benjamin P AU - Gerber, Lynn AU - Augustine, Elizabeth AU - Smith, Sharon AU - Altemus, Rosemary M AU - Mitchell, James B AU - Camphausen, Kevin A AD - Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 10-CRC, Room B2-3561, Bethesda, Maryland 20892, USA. simonen@mail.nih.gov Y1 - 2007/05/31/ PY - 2007 DA - 2007 May 31 SP - 19 VL - 2 KW - Antineoplastic Agents KW - 0 KW - Pyridones KW - pirfenidone KW - D7NLD2JX7U KW - Index Medicus KW - Administration, Oral KW - Prospective Studies KW - Humans KW - Cohort Studies KW - Treatment Outcome KW - Pain Measurement KW - Pilot Projects KW - Middle Aged KW - Male KW - Radiation Injuries -- drug therapy KW - Fibrosis -- etiology KW - Pyridones -- administration & dosage KW - Antineoplastic Agents -- administration & dosage KW - Radiotherapy -- methods KW - Fibrosis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/734209010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+oncology+%28London%2C+England%29&rft.atitle=Oral+pirfenidone+in+patients+with+chronic+fibrosis+resulting+from+radiotherapy%3A+a+pilot+study.&rft.au=Simone%2C+Nicole+L%3BSoule%2C+Benjamin+P%3BGerber%2C+Lynn%3BAugustine%2C+Elizabeth%3BSmith%2C+Sharon%3BAltemus%2C+Rosemary+M%3BMitchell%2C+James+B%3BCamphausen%2C+Kevin+A&rft.aulast=Simone&rft.aufirst=Nicole&rft.date=2007-05-31&rft.volume=2&rft.issue=&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Radiation+oncology+%28London%2C+England%29&rft.issn=1748-717X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2010-01-12 N1 - Date created - 2007-06-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Radiother Oncol. 2001 Mar;58(3):325-31 [11230895] Radiat Oncol. 2007;2:5 [17217530] Mol Genet Metab. 2002 Jul;76(3):234-42 [12126938] J Hepatol. 2002 Dec;37(6):797-805 [12445421] Intern Med. 2002 Dec;41(12):1118-23 [12521199] J Clin Oncol. 2003 Jul 1;21(13):2545-50 [12829674] Pulm Pharmacol Ther. 2003;16(4):207-14 [12850123] Semin Radiat Oncol. 2003 Jul;13(3):203-13 [12903010] Semin Radiat Oncol. 2003 Jul;13(3):274-89 [12903016] J Clin Oncol. 2004 Jun 1;22(11):2207-13 [15169810] Arch Phys Med Rehabil. 1987 Jul;68(7):438-41 [3606368] Chest. 1988 Mar;93(3):580-6 [3342669] Arch Neurol. 1989 Oct;46(10):1121-3 [2803071] Pain. 1990 Feb;40(2):171-82 [2308763] Med Care. 1992 Jun;30(6):473-83 [1593914] Important Adv Oncol. 1993;:71-80 [8505057] Int J Radiat Oncol Biol Phys. 1994 Oct 15;30(3):671-6 [7928499] Int J Radiat Biol. 1994 Oct;66(4):407-12 [7930844] Br J Radiol. 1995 Mar;68(807):331-3 [7735779] J Lab Clin Med. 1995 Jun;125(6):779-85 [7539478] Int J Radiat Oncol Biol Phys. 1995 Aug 30;33(1):233-4 [7642425] Otolaryngol Clin North Am. 1995 Oct;28(5):1003-19 [8559569] Exp Toxicol Pathol. 1995 Sep;47(4):287-91 [8855123] Toxicol Lett. 1997 Feb 7;90(2-3):125-32 [9067480] Radiother Oncol. 1998 Jun;47(3):263-9 [9681889] Clin Exp Immunol. 1998 Jul;113(1):72-6 [9697986] J Nurs Meas. 1998 Winter;6(2):111-22 [10028778] Int J Radiat Oncol Biol Phys. 1999 Mar 1;43(4):839-47 [10098440] Am J Respir Crit Care Med. 1999 Apr;159(4 Pt 1):1061-9 [10194146] J Pharmacol Exp Ther. 1999 Oct;291(1):367-73 [10490926] Ann Pharmacother. 2005 Mar;39(3):516-22 [15701781] J Exp Med. 2005 Mar 21;201(6):925-35 [15781583] Am J Respir Crit Care Med. 2005 May 1;171(9):1040-7 [15665326] Radiother Oncol. 2005 Jun;75(3):334-41 [16086914] Cancer Treat Rev. 2005 Oct;31(6):448-55 [16225996] Br J Haematol. 2001 Jul;114(1):111-3 [11472354] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Correlates of suicidal ideation among HIV-positive persons. AN - 70514294; 17502730 AB - The present investigation sought to determine the extent to which demographic characteristics, illness-related burdens, alcohol and other substance use, and psychosocial factors are independently associated with suicidal ideation in HIV-positive individuals. HIV-positive individuals in four US cities (San Francisco, Los Angeles, Milwaukee, and New York City) were screened between July 2000 and January 2002 for recruitment into a randomized behavioral prevention trial. Utilizing data from this screening visit, rates and correlates of suicidal ideation were examined in a diverse sample of 2909 HIV-positive individuals. Using binary logistic regression study sites, demographic characteristics, illness-related burdens, alcohol and substance use, and psychosocial factors were entered as predictors of suicidal ideation. This cross-sectional model thus examined the independent effects of each factor. Approximately one-fifth (19%) of participants reported thoughts of suicide in the past week. We observed that participants who were not heterosexual, rated HIV-related symptoms and medication side effects as more severe, reported regular marijuana use, and described elevated affective symptoms of depression were those who were more likely to report suicidal ideation. Conversely, participants who identified as Hispanic/Latino, individuals in a primary romantic relationship, and those who reported greater self-efficacy for coping were less likely to report suicidal ideation. Suicidal ideation among HIV-positive individuals is relatively common and is associated with multiple factors. These independent correlates may assist with identifying HIV-positive individuals who are at increased risk of suicidal ideation so that they may be assessed regularly and referred for psychological treatment when appropriate. JF - AIDS (London, England) AU - Carrico, Adam W AU - Johnson, Mallory O AU - Morin, Stephen F AU - Remien, Robert H AU - Charlebois, Edwin D AU - Steward, Wayne T AU - Chesney, Margaret A AU - NIMH Healthy Living Project Team AD - Health Psychology Program, Department of Psychiatry, University of California-San Francisco, 3333 California Street, San Francisco, CA 94143, USA. adam.carrico@ucsf.edu ; NIMH Healthy Living Project Team Y1 - 2007/05/31/ PY - 2007 DA - 2007 May 31 SP - 1199 EP - 1203 VL - 21 IS - 9 SN - 0269-9370, 0269-9370 KW - Index Medicus KW - AIDS/HIV KW - Cost of Illness KW - Adaptation, Psychological KW - Humans KW - Depression -- complications KW - Interpersonal Relations KW - Depression -- epidemiology KW - Adult KW - Substance-Related Disorders -- complications KW - Alcohol Drinking -- epidemiology KW - United States -- epidemiology KW - Sexuality -- psychology KW - Male KW - Female KW - Substance-Related Disorders -- epidemiology KW - HIV Seropositivity -- psychology KW - HIV Seropositivity -- epidemiology KW - Suicide -- psychology KW - HIV Seropositivity -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70514294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+%28London%2C+England%29&rft.atitle=Correlates+of+suicidal+ideation+among+HIV-positive+persons.&rft.au=Carrico%2C+Adam+W%3BJohnson%2C+Mallory+O%3BMorin%2C+Stephen+F%3BRemien%2C+Robert+H%3BCharlebois%2C+Edwin+D%3BSteward%2C+Wayne+T%3BChesney%2C+Margaret+A%3BNIMH+Healthy+Living+Project+Team&rft.aulast=Carrico&rft.aufirst=Adam&rft.date=2007-05-31&rft.volume=21&rft.issue=9&rft.spage=1199&rft.isbn=&rft.btitle=&rft.title=AIDS+%28London%2C+England%29&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-06 N1 - Date created - 2007-05-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Locomotor response to novelty as a predictor of reactivity to aversive stimuli in the rat. AN - 70465844; 17383617 AB - In an animal model for vulnerability to drug abuse, animals that exhibit greater motor activity in a novel environment (high responders; HR) are more sensitive to drugs of abuse and are more likely to self-administer these drugs compared to less reactive animals (low responders; LR). In the light of clinical evidence on comorbidity between drug abuse and mood disorders, we used this model to investigate whether individual differences in locomotor reactivity to novelty are related to anxiety- and depression-like responsiveness using male Sprague-Dawley rats. Animals were categorized as HR and LR based on motor responses to novelty during a 30-min session. Anxiety-like reactivity was then measured using the elevated plus-maze, the defensive withdrawal test and acoustic startle-induced ultrasonic vocalization test. Depression-like reactivity was measured by the forced swim test. HR rats showed less anxiety-like behavior in the elevated plus-maze and defensive withdrawal tests than LR, but the opposite was true in the acoustic startle-induced vocalization test. In response to a series of loud acoustic stimuli, HR rats were faster to begin vocalizing and did so for a longer duration compared to LR. There were only minor differences between LR and HR rats in the forced swim test. These data suggest that an HR/LR model can be used to study a link between vulnerability to drug abuse and anxiety-like reactivity. The exact nature of this link depends upon the model of anxiety used and may reflect the heterogeneous nature of anxiety-like reactivity in the rat. JF - Brain research AU - White, David A AU - Kalinichev, Mikhail AU - Holtzman, Stephen G AD - Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA. whitedav@nida.nih.gov Y1 - 2007/05/29/ PY - 2007 DA - 2007 May 29 SP - 141 EP - 148 VL - 1149 SN - 0006-8993, 0006-8993 KW - Index Medicus KW - Rats KW - Depression -- physiopathology KW - Animals KW - Rats, Sprague-Dawley KW - Anxiety Disorders -- physiopathology KW - Male KW - Substance-Related Disorders -- physiopathology KW - Stress, Psychological -- physiopathology KW - Behavior, Animal -- physiology KW - Anxiety -- physiopathology KW - Motor Activity -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70465844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Locomotor+response+to+novelty+as+a+predictor+of+reactivity+to+aversive+stimuli+in+the+rat.&rft.au=White%2C+David+A%3BKalinichev%2C+Mikhail%3BHoltzman%2C+Stephen+G&rft.aulast=White&rft.aufirst=David&rft.date=2007-05-29&rft.volume=1149&rft.issue=&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-16 N1 - Date created - 2007-05-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurosci. 2000 Sep 15;20(18):6983-8 [10995843] Psychopharmacology (Berl). 2000 Nov;152(4):431-9 [11140336] Psychopharmacology (Berl). 2001 Aug;157(1):31-9 [11512040] Pharmacol Biochem Behav. 2001 Apr;68(4):685-90 [11526965] Psychoneuroendocrinology. 2002 Jan-Feb;27(1-2):13-33 [11750768] Synapse. 2002 Oct;46(1):4-10 [12211093] Neuropeptides. 2002 Apr-Jun;36(2-3):117-31 [12359503] J Pharmacol Exp Ther. 2003 Feb;304(2):603-9 [12538812] J Pharmacol Exp Ther. 2003 Feb;304(2):874-80 [12538845] Eur J Pharmacol. 2003 Feb 28;463(1-3):133-43 [12600706] Eur J Pharmacol. 2003 Feb 28;463(1-3):163-75 [12600708] Eur J Pharmacol. 2003 Feb 28;463(1-3):199-216 [12600711] Neurosci Biobehav Rev. 2004 May;28(3):285-305 [15225972] Anim Behav. 1972 Feb;20(1):88-100 [4677167] Eur J Pharmacol. 1978 Feb 15;47(4):379-91 [204499] Addict Behav. 1982;7(1):97-100 [7080893] J Neurosci Methods. 1985 Aug;14(3):149-67 [2864480] Neuropharmacology. 1986 Apr;25(4):367-84 [2872608] Psychopharmacology (Berl). 1989;97(2):147-8 [2567021] Behav Neurosci. 1989 Jun;103(3):648-54 [2786722] Science. 1989 Sep 29;245(4925):1511-3 [2781295] Physiol Behav. 1990 Jul;48(1):13-7 [2236259] Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2088-92 [2006148] Pharmacol Biochem Behav. 1991 Feb;38(2):467-70 [2057515] Behav Brain Res. 1991 May 15;43(2):133-7 [1678264] Brain Res. 1991 May 10;548(1-2):305-9 [1868340] Physiol Behav. 1991 Nov;50(5):967-72 [1805287] Brain Res. 1991 Dec 13;567(1):169-74 [1726140] Physiol Behav. 1992 May;51(5):1051-6 [1615043] Synapse. 1991 Oct;9(2):121-8 [1821483] Pharmacol Biochem Behav. 1992 Aug;42(4):765-70 [1513859] Brain Res. 1993 Jan 29;602(1):169-74 [8448654] Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11738-42 [8265619] Physiol Behav. 1994 Sep;56(3):623-8 [7972418] Compr Psychiatry. 1995 Sep-Oct;36(5):329-37 [7497706] Pharmacol Biochem Behav. 1996 May;54(1):3-12 [8728533] Psychopharmacology (Berl). 1996 Jun;125(4):379-84 [8826543] J Subst Abuse. 1995;7(4):481-97 [8838629] Neuropsychobiology. 1996;34(3):136-45 [8916071] Neurosci Biobehav Rev. 1997 Nov;21(6):801-10 [9415905] Trends Pharmacol Sci. 1998 Feb;19(2):67-74 [9550944] Pharmacol Biochem Behav. 1998 Aug;60(4):785-91 [9700959] Addict Behav. 1998 Nov-Dec;23(6):893-907 [9801724] Biol Psychiatry. 1998 Dec 15;44(12):1239-47 [9861467] Physiol Behav. 1999 Aug 1;67(1):41-7 [10463627] J Comp Physiol Psychol. 1959 Feb;52(1):106-11 [13641477] Psychopharmacology (Berl). 2004 Dec;177(1-2):68-78 [15235760] Psychopharmacology (Berl). 2004 Dec;177(1-2):61-7 [15316716] Ageing Res Rev. 2005 May;4(2):141-94 [15996533] Behav Brain Res. 2005 Nov 7;164(2):222-30 [16095730] Eur J Pharmacol. 2005 Dec 5;526(1-3):36-50 [16289451] J Clin Psychiatry. 2006 Feb;67(2):247-57 [16566620] J Psychiatr Res. 2006 Sep;40(6):550-67 [16214171] J Psychiatry Neurosci. 2000 Mar;25(2):125-36 [10740986] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inhibition of breast cancer cell adhesion and bone metastasis by the extracellular adherence protein of Staphylococcus aureus AN - 20291454; 7430320 AB - Bone metastasis is a common sequelae of breast cancer and the interaction of alpha v beta 3-integrin with osteopontin (OPN) found in the extracellular matrix of mineralized tissues is implicated in this process. The integrin-dependent proadhesive and promigratory functions of OPN are particularly attributed to the 40kD N-terminal fragment that derives upon matrix metalloproteinase (MMP) cleavage. Based on the broad repertoire of interactions between Staphylococcus aureus extracellular adherence protein (Eap) and host components, we here characterized Eap to specifically interact with recombinant full-length OPN and the 40kD N-terminal MMP cleavage fragment, but not with the 32kD or the 25kD C-terminal fragments of OPN. Eap thereby prevented the OPN/ alpha v beta 3-integrin interaction, as well as the alpha v beta 3-integrin-dependent adhesion of MDA-MB-231 breast cancer cells to full-length OPN or to the 40kD fragment and the migration of these cells towards OPN. Furthermore, Eap treatment markedly impaired the development of osseous metastasis of human MDA-MB-231 cells in vivo. Taken together, Eap may represent an attractive novel treatment for the prevention of breast cancer bone metastasis. JF - Biochemical and Biophysical Research Communications AU - Schneider, D AU - Liaw, L AU - Daniel, C AU - Athanasopoulos, AN AU - Herrmann, M AU - Preissner, K T AU - Nawroth, P P AU - Chavakis, T AD - NCI, NIH, 10 Center Drive, Bethesda, MD 20892, USA, chavakist@mail.nih.gov Y1 - 2007/05/25/ PY - 2007 DA - 2007 May 25 SP - 282 EP - 288 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 357 IS - 1 SN - 0006-291X, 0006-291X KW - Biotechnology and Bioengineering Abstracts; Oncogenes & Growth Factors Abstracts; Calcium & Calcified Tissue Abstracts KW - Bone cancer KW - Matrix metalloproteinase KW - Leukocyte migration KW - Metastases KW - Cell migration KW - Staphylococcus aureus KW - Complications KW - Cell adhesion KW - Extracellular matrix KW - Osteopontin KW - Breast cancer KW - W 30905:Medical Applications KW - B 26680:Metastasis KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20291454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Inhibition+of+breast+cancer+cell+adhesion+and+bone+metastasis+by+the+extracellular+adherence+protein+of+Staphylococcus+aureus&rft.au=Schneider%2C+D%3BLiaw%2C+L%3BDaniel%2C+C%3BAthanasopoulos%2C+AN%3BHerrmann%2C+M%3BPreissner%2C+K+T%3BNawroth%2C+P+P%3BChavakis%2C+T&rft.aulast=Schneider&rft.aufirst=D&rft.date=2007-05-25&rft.volume=357&rft.issue=1&rft.spage=282&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1016%2Fj.bbrc.2007.03.143 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Staphylococcus aureus; Breast cancer; Metastases; Bone cancer; Leukocyte migration; Complications; Cell adhesion; Osteopontin; Extracellular matrix; Matrix metalloproteinase; Cell migration DO - http://dx.doi.org/10.1016/j.bbrc.2007.03.143 ER - TY - JOUR T1 - The possible role of cell cycle regulators in multistep process of HPV-associated cervical carcinoma. AN - 70645437; 17521451 AB - Human papillomavirus (HPV) 16 and 18 are associated with cervical carcinogenesis through an interaction between HPV oncogenic proteins and cell cycle regulatory genes. However, the exact pathogenetic mechanisms are not determined yet. We investigated 43 invasive squamous cell carcinoma (ISCC), 38 CIN III, 11 CINII and 18 CINI for cyclin D1, cyclin E, CDK4, p53, mdm-2, p21(waf), p27, p16(INK4A), Rb and Ki-67 aberrations using immunohistochemistry and molecular techniques. Twenty samples of normal cervical tissues (NCT) were taken as a control. There was a significant increase in the expression of Ki-67, cyclin E, CDK4, p16(INK4A), Rb (p= 0.003, 0.001, 0.001, 0.01) and a significant decrease in p27(KIP1) from NCT to ISCC (p = 0.003). Increased cyclin D1, p21(waf), p53, mdm-2 expression, homozygous deletion (HZD) and promoter methylation (PM) of the Rb were detected in CINIII and ISCC only. On univariate analysis; tumor size, differentiation, lymph node status, FIGO stage, Ki-67, cyclin D1, p53 and p27(KIP1) are significantly associated with reduced overall survival (OS) while on multivariate analysis; only FIGO stage, Ki-67, cyclin D1, p53 and p27(KIP1) were significant. 1) Aberrations involving p27(KIP1), cyclin E, CDK4, p16(INK4A) are considered early events in HPV 16 and 18-associated cervical carcinoma, whereas cyclin D1 and p53 pathway abnormalities are considered late events. 2) Immunohistochemical tests for p16(INK4A) and cyclin E, could help in early diagnosis of cervical carcinoma. 3) Only FIGO stage p53, cyclin D1, p27(KIP1) and Ki-67 are independent prognostic factors that might help in predicting outcome of cervical cancer patients. JF - BMC clinical pathology AU - Bahnassy, Abeer A AU - Zekri, Abdel Rahman N AU - Saleh, Maha AU - Lotayef, Mohammad AU - Moneir, Manar AU - Shawki, Osama AD - Pathology Department, National Cancer Institute, Cairo University, 1st Kasr El-Aini st. Cairo, Egypt. chaya200@hotmail.com Y1 - 2007/05/24/ PY - 2007 DA - 2007 May 24 SP - 4 VL - 7 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70645437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+clinical+pathology&rft.atitle=The+possible+role+of+cell+cycle+regulators+in+multistep+process+of+HPV-associated+cervical+carcinoma.&rft.au=Bahnassy%2C+Abeer+A%3BZekri%2C+Abdel+Rahman+N%3BSaleh%2C+Maha%3BLotayef%2C+Mohammad%3BMoneir%2C+Manar%3BShawki%2C+Osama&rft.aulast=Bahnassy&rft.aufirst=Abeer&rft.date=2007-05-24&rft.volume=7&rft.issue=&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=BMC+clinical+pathology&rft.issn=1472-6890&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-14 N1 - Date created - 2007-06-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 1999 Dec 15;59(24):6132-6 [10626803] Anticancer Res. 1998 Nov-Dec;18(6A):3991-8 [9891436] J Clin Pathol. 1999 Dec;52(12):880-7 [10711250] Cancer Lett. 2000 May 29;153(1-2):41-50 [10779628] Cancer. 2000 Sep 15;89(6):1300-7 [11002226] Cancer Lett. 2001 May 26;166(2):199-206 [11311493] Gynecol Oncol. 2001 Jun;81(3):341-7 [11371120] Cancer Res. 2001 Sep 1;61(17):6335-9 [11522621] Gynecol Oncol. 2001 Aug;82(2):238-46 [11531273] Cancer. 2001 Dec 15;92(12):3005-11 [11753978] Histopathology. 2001 Dec;39(6):629-37 [11903582] Gynecol Oncol. 2002 Jun;85(3):524-8 [12051885] Gynecol Oncol. 2003 Apr;89(1):140-7 [12694668] Int J Gynecol Cancer. 2003 Jul-Aug;13(4):472-9 [12911724] Hum Pathol. 2003 Aug;34(8):778-83 [14506638] Gynecol Oncol. 2003 Dec;91(3):476-85 [14675665] Hum Pathol. 2004 Jun;35(6):689-96 [15188135] BMC Cancer. 2004 Aug 31;4:58 [15339339] Kobe J Med Sci. 2004 Jan;50(1-2):9-19 [15342967] Pathol Int. 2005 Feb;55(2):53-62 [15693850] J Clin Microbiol. 1995 Apr;33(4):901-5 [7790457] Mod Pathol. 1996 Apr;9(4):418-25 [8729983] Clin Cancer Res. 2000 Jan;6(1):11-6 [10656426] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hepatoprotective Role of Endogenous Interleukin-13 in a Murine Model of Acetaminophen-Induced Liver Disease AN - 19691306; 7451001 AB - Recent evidence suggests that a deficiency in one or more hepatoprotective regulatory mechanisms may contribute to determining susceptibility in drug-induced liver disease. In the present study, we investigated the role of interleukin (IL)-13 in acetaminophen (APAP)-induced liver disease (AILD). Following APAP (200 mg/kg) administration to male C57BL/6 wild-type (WT) mice, hepatotoxicity developed up to 24 h post-APAP, with a concomitant increase in serum IL-13 concentration. Pretreatment of these mice with an IL-13-neutralizing antibody exacerbated liver injury, as did APAP administration to IL-13 knockout (KO) mice in comparison to WT mice. No difference was observed in either overall APAP-protein adduct formation or liver glutathione levels between KO and WT mice following APAP administration, suggesting that the increased susceptibility of IL-13 KO mice to AILD was not due to enhanced APAP bioactivation but rather injurious downstream events. In this regard, multiplex antibody arrays were used to identify potential IL-13-regulated biomarkers, including various cytokines and chemokines, as well as nitric oxide (NO), associated with AILD that were present at higher concentrations in the sera of APAP-treated IL-13 KO mice than in WT mice. Subsequent inhibition studies determined interferon- gamma , NO, neutrophils, natural killer cells, and natural killer cells with T-cell receptors had pathologic roles in AILD in IL-13 KO mice. Taken together, these results suggest that IL-13 is a critical hepatoprotective factor modulating the susceptibility to AILD and may provide hepatoprotection, in part, by down-regulating protoxicant factors and cells associated with the innate immune system. JF - Chemical Research in Toxicology AU - Yee, S B AU - Bourdi, M AU - Masson, MJ AU - Pohl, L R AD - Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, 9000 Rockville Pike, Building 10, Room 8N110, Bethesda, Maryland 20892, USA Y1 - 2007/05/21/ PY - 2007 DA - 2007 May 21 SP - 734 EP - 744 VL - 20 IS - 5 SN - 0893-228X, 0893-228X KW - Immunology Abstracts; Toxicology Abstracts KW - gamma -Interferon KW - Chemokines KW - Liver diseases KW - Injuries KW - Glutathione KW - Immune system KW - Adducts KW - double prime T-cell receptor KW - Leukocytes (neutrophilic) KW - Animal models KW - Natural killer cells KW - biomarkers KW - hepatotoxicity KW - Antibodies KW - Interleukin 13 KW - Nitric oxide KW - Acetaminophen KW - X 24310:Pharmaceuticals KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19691306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Research+in+Toxicology&rft.atitle=Hepatoprotective+Role+of+Endogenous+Interleukin-13+in+a+Murine+Model+of+Acetaminophen-Induced+Liver+Disease&rft.au=Yee%2C+S+B%3BBourdi%2C+M%3BMasson%2C+MJ%3BPohl%2C+L+R&rft.aulast=Yee&rft.aufirst=S&rft.date=2007-05-21&rft.volume=20&rft.issue=5&rft.spage=734&rft.isbn=&rft.btitle=&rft.title=Chemical+Research+in+Toxicology&rft.issn=0893228X&rft_id=info:doi/10.1021%2Ftx600349f LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Chemokines; Liver diseases; Injuries; Glutathione; double prime T-cell receptor; Adducts; Immune system; Natural killer cells; Animal models; Leukocytes (neutrophilic); biomarkers; hepatotoxicity; Interleukin 13; Antibodies; Nitric oxide; Acetaminophen DO - http://dx.doi.org/10.1021/tx600349f ER - TY - CPAPER T1 - Analysis of Adverse Events in Clinical Trials using Data Mining T2 - 28th Annual Meeting of the Society for Clinical Trials (SCT 2007) AN - 40678296; 4586064 JF - 28th Annual Meeting of the Society for Clinical Trials (SCT 2007) AU - Pan, Jeng-Jong Y1 - 2007/05/20/ PY - 2007 DA - 2007 May 20 KW - Clinical trials KW - Data processing KW - Mining KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40678296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=28th+Annual+Meeting+of+the+Society+for+Clinical+Trials+%28SCT+2007%29&rft.atitle=Analysis+of+Adverse+Events+in+Clinical+Trials+using+Data+Mining&rft.au=Pan%2C+Jeng-Jong&rft.aulast=Pan&rft.aufirst=Jeng-Jong&rft.date=2007-05-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=28th+Annual+Meeting+of+the+Society+for+Clinical+Trials+%28SCT+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sctweb.org/2007files/2007finalpreliminaryprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Negative Affect and Excessive Alcohol Drinking Driven by Central CRF Systems: Reversal by the Nvel CRF1 Antagonist MTIP T2 - 2007 Annual Meeting of the American Psychiatric Association AN - 39459876; 4610806 JF - 2007 Annual Meeting of the American Psychiatric Association AU - Heilig, M Y1 - 2007/05/19/ PY - 2007 DA - 2007 May 19 KW - Alcohols KW - Corticotropin-releasing hormone KW - Ethanol KW - Drinking behavior KW - Emotions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39459876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Psychiatric+Association&rft.atitle=Negative+Affect+and+Excessive+Alcohol+Drinking+Driven+by+Central+CRF+Systems%3A+Reversal+by+the+Nvel+CRF1+Antagonist+MTIP&rft.au=Heilig%2C+M&rft.aulast=Heilig&rft.aufirst=M&rft.date=2007-05-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Psychiatric+Association&rft.issn=&rft_id=info:doi/ L2 - http://abstractsonline.com/viewer/?mkey=%7B2679A738%2D1A1B%2D43DD%2DB2 73%2DACA44BB095A0%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Variation at the CRH Locus and its Association with Anxiety and Alcohol Consumption- Lessons from the Macaque T2 - 2007 Annual Meeting of the American Psychiatric Association AN - 39399155; 4610811 JF - 2007 Annual Meeting of the American Psychiatric Association AU - Barr, C S Y1 - 2007/05/19/ PY - 2007 DA - 2007 May 19 KW - Alcohols KW - Genetic diversity KW - Anxiety KW - Corticotropin-releasing hormone KW - Macaca KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39399155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Psychiatric+Association&rft.atitle=Genetic+Variation+at+the+CRH+Locus+and+its+Association+with+Anxiety+and+Alcohol+Consumption-+Lessons+from+the+Macaque&rft.au=Barr%2C+C+S&rft.aulast=Barr&rft.aufirst=C&rft.date=2007-05-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Psychiatric+Association&rft.issn=&rft_id=info:doi/ L2 - http://abstractsonline.com/viewer/?mkey=%7B2679A738%2D1A1B%2D43DD%2DB2 73%2DACA44BB095A0%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adapting the Combine Trial Findings for Clinical Practice: The 2006 NIAAA Clinicians Guide T2 - 2007 Annual Meeting of the American Psychiatric Association AN - 39380547; 4611084 JF - 2007 Annual Meeting of the American Psychiatric Association AU - Willenbring, M L Y1 - 2007/05/19/ PY - 2007 DA - 2007 May 19 KW - Training KW - Clinical trials KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39380547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Psychiatric+Association&rft.atitle=Adapting+the+Combine+Trial+Findings+for+Clinical+Practice%3A+The+2006+NIAAA+Clinicians+Guide&rft.au=Willenbring%2C+M+L&rft.aulast=Willenbring&rft.aufirst=M&rft.date=2007-05-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Psychiatric+Association&rft.issn=&rft_id=info:doi/ L2 - http://abstractsonline.com/viewer/?mkey=%7B2679A738%2D1A1B%2D43DD%2DB2 73%2DACA44BB095A0%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dietary Supplement Database for Consumers T2 - 2007 Conference of the Medical Library Association (MLA 2007) AN - 39325687; 4613304 JF - 2007 Conference of the Medical Library Association (MLA 2007) AU - Chang, Hua F AU - Hudson, Vera W AU - Sun, Ying AU - Moore, Dorothy AU - Hazard, George AU - Goshorn, Jeanne Y1 - 2007/05/19/ PY - 2007 DA - 2007 May 19 KW - Dietary supplements KW - Consumers KW - Databases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39325687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Conference+of+the+Medical+Library+Association+%28MLA+2007%29&rft.atitle=Dietary+Supplement+Database+for+Consumers&rft.au=Chang%2C+Hua+F%3BHudson%2C+Vera+W%3BSun%2C+Ying%3BMoore%2C+Dorothy%3BHazard%2C+George%3BGoshorn%2C+Jeanne&rft.aulast=Chang&rft.aufirst=Hua&rft.date=2007-05-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Conference+of+the+Medical+Library+Association+%28MLA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B9443EE70-D89B-4347-BC63 -467154391C33%7D%20 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neurobiology of Bipolar Depression: Implications for Treatment T2 - 2007 Annual Meeting of the American Psychiatric Association AN - 39314279; 4610646 JF - 2007 Annual Meeting of the American Psychiatric Association AU - Post, R M Y1 - 2007/05/19/ PY - 2007 DA - 2007 May 19 KW - Depression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39314279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Psychiatric+Association&rft.atitle=Neurobiology+of+Bipolar+Depression%3A+Implications+for+Treatment&rft.au=Post%2C+R+M&rft.aulast=Post&rft.aufirst=R&rft.date=2007-05-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Psychiatric+Association&rft.issn=&rft_id=info:doi/ L2 - http://abstractsonline.com/viewer/?mkey=%7B2679A738%2D1A1B%2D43DD%2DB2 73%2DACA44BB095A0%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dimensional Approaches to Diagnosing Addictive Disorders T2 - 2007 Annual Meeting of the American Psychiatric Association AN - 39304972; 4610840 JF - 2007 Annual Meeting of the American Psychiatric Association AU - Compton, W M Y1 - 2007/05/19/ PY - 2007 DA - 2007 May 19 KW - Classification KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39304972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Psychiatric+Association&rft.atitle=Dimensional+Approaches+to+Diagnosing+Addictive+Disorders&rft.au=Compton%2C+W+M&rft.aulast=Compton&rft.aufirst=W&rft.date=2007-05-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Psychiatric+Association&rft.issn=&rft_id=info:doi/ L2 - http://abstractsonline.com/viewer/?mkey=%7B2679A738%2D1A1B%2D43DD%2DB2 73%2DACA44BB095A0%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Filamin A-mediated down-regulation of the exchange factor Ras-GRF1 correlates with decreased matrix metalloproteinase-9 expression in human melanoma cells. AN - 70500364; 17389601 AB - The actin-binding protein filamin A (FLNa) is associated with diverse cellular processes such as cell motility and signaling through its scaffolding properties. Here we examine the effect of FLNa on the regulation of signaling pathways that control the expression of matrix metalloproteinases (MMPs). The lack of FLNa in human M2 melanoma cells was associated with constitutive and phorbol ester-induced expression and secretion of active MMP-9 in the absence of MMP-2 up-regulation. M2 cells displayed stronger MMP-9 production and activity than their M2A7 counterparts where FLNa had been stably reintroduced. Using an MMP-9 promoter construct (pMMP-9-Luc), in vitro kinase assays, and genetic and pharmacological approaches, we demonstrate that FLNa mediated transcriptional down-regulation of pMMP-9-Luc by suppressing the constitutive hyperactivity of the Ras/MAPK extracellular signal-regulated kinase (ERK) cascade. Experimental evidence indicated that this phenomenon was associated with destabilization and ubiquitylation of Ras-GRF1, a guanine nucleotide exchange factor that activates H-Ras by facilitating the release of GDP. Ectopic expression of Ras-GRF1 was accompanied by ERK activation and elevated levels of MMP-9 in M2A7 cells, whereas a catalytically inactive dominant negative Ras-GRF1, which prevented ERK activation, reduced MMP-9 expression in M2 cells. Our results indicate that expression of FLNa regulates constitutive activation of the Ras/ERK pathway partly through a Ras-GRF1 mechanism to modulate the production of MMP-9. JF - The Journal of biological chemistry AU - Zhu, Tie-Nian AU - He, Hua-Jun AU - Kole, Sutapa AU - D'Souza, Theresa AU - Agarwal, Rachana AU - Morin, Patrice J AU - Bernier, Michel AD - Diabetes Section, Laboratory of Clinical Investigation, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA. Y1 - 2007/05/18/ PY - 2007 DA - 2007 May 18 SP - 14816 EP - 14826 VL - 282 IS - 20 SN - 0021-9258, 0021-9258 KW - Carcinogens KW - 0 KW - Contractile Proteins KW - Filamins KW - Microfilament Proteins KW - ras-GRF1 KW - Matrix Metalloproteinase 2 KW - EC 3.4.24.24 KW - Matrix Metalloproteinase 9 KW - EC 3.4.24.35 KW - Proto-Oncogene Proteins p21(ras) KW - EC 3.6.5.2 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Proto-Oncogene Proteins p21(ras) -- metabolism KW - Carcinogens -- pharmacology KW - Humans KW - Cell Movement -- drug effects KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Cell Line, Tumor KW - Down-Regulation -- drug effects KW - Melanoma KW - Matrix Metalloproteinase 2 -- biosynthesis KW - MAP Kinase Signaling System -- drug effects KW - Contractile Proteins -- biosynthesis KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Microfilament Proteins -- biosynthesis KW - ras-GRF1 -- metabolism KW - Matrix Metalloproteinase 9 -- biosynthesis KW - Gene Expression Regulation, Neoplastic -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70500364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Filamin+A-mediated+down-regulation+of+the+exchange+factor+Ras-GRF1+correlates+with+decreased+matrix+metalloproteinase-9+expression+in+human+melanoma+cells.&rft.au=Zhu%2C+Tie-Nian%3BHe%2C+Hua-Jun%3BKole%2C+Sutapa%3BD%27Souza%2C+Theresa%3BAgarwal%2C+Rachana%3BMorin%2C+Patrice+J%3BBernier%2C+Michel&rft.aulast=Zhu&rft.aufirst=Tie-Nian&rft.date=2007-05-18&rft.volume=282&rft.issue=20&rft.spage=14816&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-18 N1 - Date created - 2007-05-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Multivitamin use and risk of prostate cancer in the National Institutes of Health-AARP Diet and Health Study. AN - 70516974; 17505071 AB - Multivitamin supplements are used by millions of Americans because of their potential health benefits, but the relationship between multivitamin use and prostate cancer is unclear. We prospectively investigated the association between multivitamin use and risk of prostate cancer (localized, advanced, and fatal) in 295,344 men enrolled in the National Institutes of Health (NIH)-AARP Diet and Health Study who were cancer free at enrollment in 1995 and 1996. During 5 years of follow-up, 10,241 participants were diagnosed with incident prostate cancer, including 8765 localized and 1476 advanced cancers. In a separate mortality analysis with 6 years of follow-up, 179 cases of fatal prostate cancer were ascertained. Multivitamin use was assessed at baseline as part of a self-administered, mailed food-frequency questionnaire. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated by use of Cox proportional hazards regression, adjusted for established or suspected prostate cancer risk factors. No association was observed between multivitamin use and risk of localized prostate cancer. However, we found an increased risk of advanced and fatal prostate cancers (RR = 1.32, 95% CI = 1.04 to 1.67 and RR = 1.98, 95% CI = 1.07 to 3.66, respectively) among men reporting excessive use of multivitamins (more than seven times per week) when compared with never users. The incidence rates per 100,000 person-years for advanced and fatal prostate cancers for those who took a multivitamin more than seven times per week were 143.8 and 18.9, respectively, compared with 113.4 and 11.4 in never users. The positive associations with excessive multivitamin use were strongest in men with a family history of prostate cancer or who took individual micronutrient supplements, including selenium, beta-carotene, or zinc. These results suggest that regular multivitamin use is not associated with the risk of early or localized prostate cancer. The possibility that men taking high levels of multivitamins along with other supplements have increased risk of advanced and fatal prostate cancers is of concern and merits further evaluation. JF - Journal of the National Cancer Institute AU - Lawson, Karla A AU - Wright, Margaret E AU - Subar, Amy AU - Mouw, Traci AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Leitzmann, Michael F AD - Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA. lawsonka@mail.nih.gov Y1 - 2007/05/16/ PY - 2007 DA - 2007 May 16 SP - 754 EP - 764 VL - 99 IS - 10 KW - Vitamins KW - 0 KW - Index Medicus KW - United States KW - Risk Factors KW - Humans KW - National Institutes of Health (U.S.) KW - Cohort Studies KW - Surveys and Questionnaires KW - Aged KW - Middle Aged KW - Male KW - Vitamins -- adverse effects KW - Prostatic Neoplasms -- chemically induced KW - Dietary Supplements -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70516974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Multivitamin+use+and+risk+of+prostate+cancer+in+the+National+Institutes+of+Health-AARP+Diet+and+Health+Study.&rft.au=Lawson%2C+Karla+A%3BWright%2C+Margaret+E%3BSubar%2C+Amy%3BMouw%2C+Traci%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BLeitzmann%2C+Michael+F&rft.aulast=Lawson&rft.aufirst=Karla&rft.date=2007-05-16&rft.volume=99&rft.issue=10&rft.spage=754&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-12 N1 - Date created - 2007-05-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Natl Cancer Inst. 2007 Oct 3;99(19):1491-2; author reply 1492-3 [17895477] Nutr Cancer. 2008;60(1):1-6 [18444129] J Natl Cancer Inst. 2007 May 16;99(10):742-3 [17505064] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chronic swim stress alters sensitivity to acute behavioral effects of ethanol in mice. AN - 70434970; 17363014 AB - Epidemiological data support a strong link between stress, stress-related disorders and risk for alcoholism. However, precisely how stress might impact sensitivity to the intoxicating effects of ethanol or the willingness to voluntary consume ethanol remains unclear. The present study assessed the effects of daily exposure to forced swim stress on subsequent sensitivity to the sedative/hypnotic, hypothermic, ataxic (measured using accelerating rotarod), and anxiolytic-like (measured using elevated plus-maze) effects of ethanol, and ethanol consumption and preference in a two-bottle choice paradigm, in male C57BL/6J mice. Stress effects on the sedative/hypnotic effects of the barbiturate pentobarbital were also tested. Results showed that chronic (fourteen days) but not acute (one or three days) swim stress significantly potentiated the sedative/hypnotic and hypothermic effects of 4 g/kg, but not 3 g/kg, ethanol. The sedative/hypnotic effects of pentobarbital were attenuated by chronic swim stress. Irrespective of chronicity, swim stress did not alter the ataxic or anxiolytic-like effects of ethanol, or alter ethanol self-administration either during or after stress. These data provide further evidence that stress alters the intoxicating effects of high doses of ethanol in a behaviorally selective manner. JF - Physiology & behavior AU - Boyce-Rustay, Janel M AU - Cameron, Heather A AU - Holmes, Andrew AD - Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, United States. janel.boyce-rustay@abbott.com Y1 - 2007/05/16/ PY - 2007 DA - 2007 May 16 SP - 77 EP - 86 VL - 91 IS - 1 SN - 0031-9384, 0031-9384 KW - Central Nervous System Depressants KW - 0 KW - Hypnotics and Sedatives KW - Ethanol KW - 3K9958V90M KW - Pentobarbital KW - I4744080IR KW - Index Medicus KW - Animals KW - Ataxia -- chemically induced KW - Body Temperature -- drug effects KW - Dose-Response Relationship, Drug KW - Neurosecretory Systems -- drug effects KW - Mice KW - Hypnotics and Sedatives -- pharmacology KW - Postural Balance -- drug effects KW - Pentobarbital -- pharmacology KW - Hypothermia -- etiology KW - Hypothermia -- physiopathology KW - Mice, Inbred C57BL KW - Alcohol Drinking -- psychology KW - Chronic Disease KW - Neurosecretory Systems -- physiology KW - Male KW - Ataxia -- psychology KW - Swimming -- psychology KW - Central Nervous System Depressants -- pharmacology KW - Behavior, Animal -- drug effects KW - Ethanol -- pharmacology KW - Stress, Psychological -- physiopathology KW - Stress, Psychological -- psychology KW - Stress, Psychological -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70434970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physiology+%26+behavior&rft.atitle=Chronic+swim+stress+alters+sensitivity+to+acute+behavioral+effects+of+ethanol+in+mice.&rft.au=Boyce-Rustay%2C+Janel+M%3BCameron%2C+Heather+A%3BHolmes%2C+Andrew&rft.aulast=Boyce-Rustay&rft.aufirst=Janel&rft.date=2007-05-16&rft.volume=91&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Physiology+%26+behavior&rft.issn=00319384&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-03 N1 - Date created - 2007-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mutations in clusters and showers. AN - 70509495; 17495029 JF - Proceedings of the National Academy of Sciences of the United States of America AU - Drake, John W AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. drake@niehs.nih.gov Y1 - 2007/05/15/ PY - 2007 DA - 2007 May 15 SP - 8203 EP - 8204 VL - 104 IS - 20 SN - 0027-8424, 0027-8424 KW - DNA, Intergenic KW - 0 KW - Index Medicus KW - Animals KW - Genetic Vectors KW - Base Pairing -- genetics KW - Mice KW - DNA, Intergenic -- genetics KW - Mice, Transgenic KW - Male KW - Mutation -- genetics KW - Mutagenesis -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70509495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Mutations+in+clusters+and+showers.&rft.au=Drake%2C+John+W&rft.aulast=Drake&rft.aufirst=John&rft.date=2007-05-15&rft.volume=104&rft.issue=20&rft.spage=8203&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-02 N1 - Date created - 2007-05-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2004 Apr 23;279(17):16895-8 [14988392] Mutat Res. 2000 Sep 18;452(2):219-29 [11024481] Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1437-42 [11818556] Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14878-83 [12403824] Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):776-81 [12552134] Proc Natl Acad Sci U S A. 2007 May 15;104(20):8403-8 [17485671] Nature. 1970 Dec 12;228(5276):1045-7 [5483159] Genetics. 1991 Nov;129(3):957-62 [1752431] Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10015-9 [9707592] Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12849-54 [16118275] Comment On: Proc Natl Acad Sci U S A. 2007 May 15;104(20):8403-8 [17485671] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo. AN - 70504850; 17504939 AB - Selection of the AUG start codon is a key step in translation initiation requiring hydrolysis of GTP in the eIF2*GTP*Met-tRNA(i)(Met) ternary complex (TC) and subsequent P(i) release from eIF2*GDP*P(i). It is thought that eIF1 prevents recognition of non-AUGs by promoting scanning and blocking P(i) release at non-AUG codons. We show that Sui(-) mutations in Saccharomyces cerevisiae eIF1, which increase initiation at UUG codons, reduce interaction of eIF1 with 40S subunits in vitro and in vivo, and both defects are diminished in cells by overexpressing the mutant proteins. Remarkably, Sui(-) mutation ISQLG(93-97)ASQAA (abbreviated 93-97) accelerates eIF1 dissociation and P(i) release from reconstituted preinitiation complexes (PICs), whereas a hyperaccuracy mutation in eIF1A (that suppresses Sui(-) mutations) decreases the eIF1 off-rate. These findings demonstrate that eIF1 dissociation is a critical step in start codon selection, which is modulated by eIF1A. We also describe Gcd(-) mutations in eIF1 that impair TC loading on 40S subunits or destabilize the multifactor complex containing eIF1, eIF3, eIF5, and TC, showing that eIF1 promotes PIC assembly in vivo beyond its important functions in AUG selection. JF - Genes & development AU - Cheung, Yuen-Nei AU - Maag, David AU - Mitchell, Sarah F AU - Fekete, Christie A AU - Algire, Mikkel A AU - Takacs, Julie E AU - Shirokikh, Nikolay AU - Pestova, Tatyana AU - Lorsch, Jon R AU - Hinnebusch, Alan G AD - Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2007/05/15/ PY - 2007 DA - 2007 May 15 SP - 1217 EP - 1230 VL - 21 IS - 10 SN - 0890-9369, 0890-9369 KW - Codon, Initiator KW - 0 KW - Eukaryotic Initiation Factor-1 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Models, Molecular KW - Electrophoresis, Polyacrylamide Gel KW - Mutation -- genetics KW - Saccharomyces cerevisiae -- genetics KW - Codon, Initiator -- physiology KW - Codon, Initiator -- genetics KW - Eukaryotic Initiation Factor-1 -- metabolism KW - Protein Biosynthesis -- physiology KW - Ribosome Subunits, Small, Eukaryotic -- metabolism KW - Eukaryotic Initiation Factor-1 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70504850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genes+%26+development&rft.atitle=Dissociation+of+eIF1+from+the+40S+ribosomal+subunit+is+a+key+step+in+start+codon+selection+in+vivo.&rft.au=Cheung%2C+Yuen-Nei%3BMaag%2C+David%3BMitchell%2C+Sarah+F%3BFekete%2C+Christie+A%3BAlgire%2C+Mikkel+A%3BTakacs%2C+Julie+E%3BShirokikh%2C+Nikolay%3BPestova%2C+Tatyana%3BLorsch%2C+Jon+R%3BHinnebusch%2C+Alan+G&rft.aulast=Cheung&rft.aufirst=Yuen-Nei&rft.date=2007-05-15&rft.volume=21&rft.issue=10&rft.spage=1217&rft.isbn=&rft.btitle=&rft.title=Genes+%26+development&rft.issn=08909369&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-02 N1 - Date created - 2007-05-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2000 Jan 20;403(6767):332-5 [10659855] Mol Cell Biol. 1998 Aug;18(8):4935-46 [9671501] Nature. 1998 Aug 27;394(6696):854-9 [9732867] Genes Dev. 2004 Dec 15;18(24):3078-93 [15601822] Mol Cell. 2005 Jan 21;17(2):265-75 [15664195] Annu Rev Microbiol. 2005;59:407-50 [16153175] EMBO J. 2005 Oct 19;24(20):3588-601 [16193068] Mol Cell. 2005 Oct 28;20(2):251-62 [16246727] Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16164-9 [16254050] J Mol Biol. 2006 Feb 24;356(3):724-37 [16380131] Mol Cell Biol. 2006 Feb;26(4):1355-72 [16449648] EMBO J. 2007 Mar 21;26(6):1602-14 [17332751] J Biol Chem. 1982 Nov 10;257(21):13062-7 [6215406] Anal Biochem. 2000 Jun 15;282(1):158-61 [10860516] Genes Dev. 2000 Oct 1;14(19):2534-46 [11018020] EMBO J. 2001 Feb 15;20(4):891-904 [11179233] EMBO J. 2001 May 1;20(9):2326-37 [11331597] RNA. 2002 Mar;8(3):382-97 [12008673] EMBO J. 2002 Nov 1;21(21):5886-98 [12411506] Genes Dev. 2002 Nov 15;16(22):2906-22 [12435632] EMBO J. 2003 Jan 15;22(2):193-204 [12514125] J Mol Biol. 2003 Jul 25;330(5):917-24 [12860115] RNA. 2003 Aug;9(8):1019-24 [12869712] Genes Dev. 2003 Nov 15;17(22):2786-97 [14600024] EMBO J. 2004 Mar 10;23(5):1166-77 [14976554] J Biol Chem. 2004 Jul 23;279(30):31910-20 [15145951] Mol Cell Biol. 2004 Nov;24(21):9437-55 [15485912] Mol Cell Biol. 1991 May;11(5):2723-35 [2017175] Mol Cell Biol. 1992 Jan;12(1):248-60 [1729602] J Biol Chem. 1995 Mar 3;270(9):4288-92 [7876188] Mol Cell Biol. 1998 Mar;18(3):1506-16 [9488467] J Biol Chem. 1998 Jul 17;273(29):18573-85 [9660829] Comment In: Genes Dev. 2007 Jun 1;21(11):1280-7 [17545463] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characterization of novel non-nucleoside reverse transcriptase (RT) inhibitor resistance mutations at residues 132 and 135 in the 51 kDa subunit of HIV-1 RT. AN - 70404049; 17286555 AB - Several rare and novel NNRTI [non-nucleoside reverse transcriptase (RT) inhibitor] resistance mutations were recently detected at codons 132 and 135 in RTs from clinical isolates using the yeast-based chimaeric TyHRT (Ty1/HIV-1 RT) phenotypic assay. Ile132 and Ile135 form part of the beta7-beta8 loop of HIV-1 RT (residues 132-140). To elucidate the contribution of these residues in RT structure-function and drug resistance, we constructed twelve recombinant enzymes harbouring mutations at codons 132 and 135-140. Several of the mutant enzymes exhibited reduced DNA polymerase activities. Using the yeast two-hybrid assay for HIV-1 RT dimerization we show that in some instances this decrease in enzyme activity could be attributed to the mutations, in the context of the 51 kDa subunit of HIV-1 RT, disrupting the subunit-subunit interactions of the enzyme. Drug resistance analyses using purified RT, the TyHRT assay and antiviral assays demonstrated that the I132M mutation conferred high-level resistance (>10-fold) to nevirapine and delavirdine and low-level resistance (approximately 2-3-fold) to efavirenz. The I135A and I135M mutations also conferred low level NNRTI resistance (approximately 2-fold). Subunit selective mutagenesis studies again demonstrated that resistance was conferred via the p51 subunit of HIV-1 RT. Taken together, our results highlight a specific role of residues 132 and 135 in NNRTI resistance and a general role for residues in the beta7-beta8 loop in the stability of HIV-1 RT. JF - The Biochemical journal AU - Nissley, Dwight V AU - Radzio, Jessica AU - Ambrose, Zandrea AU - Sheen, Chih-Wei AU - Hamamouch, Noureddine AU - Moore, Katie L AU - Tachedjian, Gilda AU - Sluis-Cremer, Nicolas AD - Basic Research Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA. Y1 - 2007/05/15/ PY - 2007 DA - 2007 May 15 SP - 151 EP - 157 VL - 404 IS - 1 KW - DNA, Viral KW - 0 KW - Protein Subunits KW - RNA, Viral KW - Recombinant Proteins KW - Reverse Transcriptase Inhibitors KW - HIV Reverse Transcriptase KW - EC 2.7.7.49 KW - Index Medicus KW - Saccharomyces cerevisiae -- genetics KW - DNA, Viral -- biosynthesis KW - Recombinant Proteins -- metabolism KW - Models, Molecular KW - Circular Dichroism KW - HIV-1 -- enzymology KW - Recombinant Proteins -- chemistry KW - Molecular Conformation KW - Protein Subunits -- metabolism KW - RNA, Viral -- metabolism KW - Protein Conformation KW - Cloning, Molecular KW - Reverse Transcriptase Inhibitors -- chemistry KW - HIV Reverse Transcriptase -- genetics KW - Reverse Transcriptase Inhibitors -- pharmacology KW - HIV Reverse Transcriptase -- metabolism KW - HIV Reverse Transcriptase -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70404049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Biochemical+journal&rft.atitle=Characterization+of+novel+non-nucleoside+reverse+transcriptase+%28RT%29+inhibitor+resistance+mutations+at+residues+132+and+135+in+the+51+kDa+subunit+of+HIV-1+RT.&rft.au=Nissley%2C+Dwight+V%3BRadzio%2C+Jessica%3BAmbrose%2C+Zandrea%3BSheen%2C+Chih-Wei%3BHamamouch%2C+Noureddine%3BMoore%2C+Katie+L%3BTachedjian%2C+Gilda%3BSluis-Cremer%2C+Nicolas&rft.aulast=Nissley&rft.aufirst=Dwight&rft.date=2007-05-15&rft.volume=404&rft.issue=1&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=The+Biochemical+journal&rft.issn=1470-8728&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-22 N1 - Date created - 2007-04-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6334-9 [10841542] FEBS J. 2006 Aug;273(16):3850-60 [16911530] Biochemistry. 2001 Aug 14;40(32):9505-12 [11583149] J Virol. 2004 May;78(10):5390-401 [15113918] Eur J Biochem. 1990 Jan 26;187(2):307-14 [1688798] J Biol Chem. 1990 Jun 5;265(16):8986-8 [1693146] FEBS Lett. 1991 Oct 7;291(1):1-5 [1718777] Science. 1992 Jun 26;256(5065):1783-90 [1377403] Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6599-603 [7517553] Methods Enzymol. 1995;262:130-44 [8594344] Nature. 1996 Mar 7;380(6569):30 [8598898] Antimicrob Agents Chemother. 1997 Dec;41(12):2781-5 [9420060] Antiviral Res. 1998 Jun;38(3):153-79 [9754886] J Virol. 1998 Nov;72(11):9337-44 [9765485] Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13905-10 [9811899] Eur J Biochem. 1999 Apr;261(1):10-8 [10103027] J Virol. 2004 Dec;78(24):13553-61 [15564466] FEBS Lett. 2005 Apr 25;579(11):2294-300 [15848161] Proteins. 2005 Jul 1;60(1):5-13 [15852304] J Infect Dis. 2005 Jul 1;192(1):24-9 [15942890] Mol Pharmacol. 2005 Jul;68(1):49-60 [15833734] Antimicrob Agents Chemother. 2005 Jul;49(7):2648-56 [15980332] Mol Pharmacol. 2005 Sep;68(3):652-9 [15961674] Antimicrob Agents Chemother. 2005 Oct;49(10):4046-51 [16189079] Antimicrob Agents Chemother. 2005 Nov;49(11):4465-73 [16251284] J Clin Microbiol. 2005 Nov;43(11):5696-704 [16272507] Curr Pharm Des. 2006;12(11):1339-55 [16611119] Antiviral Res. 2006 Jun;70(2):66-74 [16472877] J Clin Microbiol. 2006 Jul;44(7):2612-4 [16825395] J Virol. 2000 Nov;74(22):10269-73 [11044070] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Evaluations of Pulsed High Intensity Focused Ultrasound Exposures for enhancing the Synergistic Effects of TNFa plasmid and Bortezomib in a Murine Squamous Cell Carcinoma T2 - 2007 Joint Annual Meeting of the World Conference on Interventional Oncology and Society for Thermal Medicine (WCIO/STM 2007) AN - 40665654; 4582510 JF - 2007 Joint Annual Meeting of the World Conference on Interventional Oncology and Society for Thermal Medicine (WCIO/STM 2007) AU - Shah, S Y1 - 2007/05/14/ PY - 2007 DA - 2007 May 14 KW - Tumor necrosis factor-a KW - Squamous cell carcinoma KW - Plasmids KW - Ultrasound KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40665654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Joint+Annual+Meeting+of+the+World+Conference+on+Interventional+Oncology+and+Society+for+Thermal+Medicine+%28WCIO%2FSTM+2007%29&rft.atitle=Evaluations+of+Pulsed+High+Intensity+Focused+Ultrasound+Exposures+for+enhancing+the+Synergistic+Effects+of+TNFa+plasmid+and+Bortezomib+in+a+Murine+Squamous+Cell+Carcinoma&rft.au=Shah%2C+S&rft.aulast=Shah&rft.aufirst=S&rft.date=2007-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Joint+Annual+Meeting+of+the+World+Conference+on+Interventional+Oncology+and+Society+for+Thermal+Medicine+%28WCIO%2FSTM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.wcio2007.com/program.cgi LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effects of Pulsed High-Intensity Focused Ultrasound Exposures on Metastasis T2 - 2007 Joint Annual Meeting of the World Conference on Interventional Oncology and Society for Thermal Medicine (WCIO/STM 2007) AN - 40664822; 4582560 JF - 2007 Joint Annual Meeting of the World Conference on Interventional Oncology and Society for Thermal Medicine (WCIO/STM 2007) AU - Shih, J Y1 - 2007/05/14/ PY - 2007 DA - 2007 May 14 KW - Metastases KW - Ultrasound KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40664822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Joint+Annual+Meeting+of+the+World+Conference+on+Interventional+Oncology+and+Society+for+Thermal+Medicine+%28WCIO%2FSTM+2007%29&rft.atitle=The+Effects+of+Pulsed+High-Intensity+Focused+Ultrasound+Exposures+on+Metastasis&rft.au=Shih%2C+J&rft.aulast=Shih&rft.aufirst=J&rft.date=2007-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Joint+Annual+Meeting+of+the+World+Conference+on+Interventional+Oncology+and+Society+for+Thermal+Medicine+%28WCIO%2FSTM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.wcio2007.com/program.cgi LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Clinical Toxicity in Patients Undergoing Percutaneous Intra-Arterial Hepatic Perfusion (PHP) with Melphalan for Unresectable Hepatic Malignancies T2 - 2007 Joint Annual Meeting of the World Conference on Interventional Oncology and Society for Thermal Medicine (WCIO/STM 2007) AN - 40664549; 4582518 JF - 2007 Joint Annual Meeting of the World Conference on Interventional Oncology and Society for Thermal Medicine (WCIO/STM 2007) AU - Pingpank, J F AU - Royal, R E AU - Alexander, H R AU - Horne, M K AU - Wood, B J AU - Neeman, Z AU - Kam, A W AU - Libutti, S K AU - Hughes, M S AU - Kammula, U S AU - Beresneva, T AU - Ohl, S E Y1 - 2007/05/14/ PY - 2007 DA - 2007 May 14 KW - Liver KW - Toxicity KW - Melphalan KW - Malignancy KW - Perfusion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40664549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Joint+Annual+Meeting+of+the+World+Conference+on+Interventional+Oncology+and+Society+for+Thermal+Medicine+%28WCIO%2FSTM+2007%29&rft.atitle=Analysis+of+Clinical+Toxicity+in+Patients+Undergoing+Percutaneous+Intra-Arterial+Hepatic+Perfusion+%28PHP%29+with+Melphalan+for+Unresectable+Hepatic+Malignancies&rft.au=Pingpank%2C+J+F%3BRoyal%2C+R+E%3BAlexander%2C+H+R%3BHorne%2C+M+K%3BWood%2C+B+J%3BNeeman%2C+Z%3BKam%2C+A+W%3BLibutti%2C+S+K%3BHughes%2C+M+S%3BKammula%2C+U+S%3BBeresneva%2C+T%3BOhl%2C+S+E&rft.aulast=Pingpank&rft.aufirst=J&rft.date=2007-05-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Joint+Annual+Meeting+of+the+World+Conference+on+Interventional+Oncology+and+Society+for+Thermal+Medicine+%28WCIO%2FSTM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.wcio2007.com/program.cgi LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Breast cancer in the elderly. AN - 70468559; 17488987 AB - Screening and adjuvant postoperative therapies have increased survival among women with breast cancer. These tools are seldom applied in elderly patients, although the usually reported incidence of breast cancer is close to 50% in women 65 years or older, reaching 47% after 70 years in the updated Surveillance, Epidemiology, and End Results (SEER) database. Elderly breast cancer patients, even if in good medical health, were frequently excluded from adjuvant clinical trials. Women age 70 years who are fit actually have a median life expectancy of 15.5 years, ie, half of them will live much longer and will remain exposed for enough time to the potentially preventable risks of a relapse and specific death. In the last few years, a new concern about this issue has developed. Treatment now faces two major end points, as in younger women: to improve disease-free survival in the early stages, and to palliate symptoms in advanced disease. However, in both settings, the absolute benefit of treatment is critical because protecting quality of life and all its related aspects (especially functional status and independence), is crucial in older persons who have more limited life expectancy. Furthermore, the new hormonal compounds (aromatase inhibitors) and chemotherapeutic drugs (capecitabine, liposomal doxorubicin), are potentially less toxic than and equally as effective as older more established therapies. These new treatments bring new challenges including higher cost, and defining their benefit in elderly breast cancer must include an analysis of the cost/benefit ratio. These issues emphasize the urgent need to develop and support clinical trials for this older population of breast cancer patients both in the adjuvant and metastatic settings, a move that will take us from a prejudiced, age-based medicine to an evidence-based medicine. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Crivellari, Diana AU - Aapro, Matti AU - Leonard, Robert AU - von Minckwitz, Gunter AU - Brain, Etienne AU - Goldhirsch, Aron AU - Veronesi, Andrea AU - Muss, Hyman AD - Division of Medical Oncology C, Centro di Riferimento Oncologico National Cancer Institute, Aviano, PN Italy. dcrivellari@cro.it Y1 - 2007/05/10/ PY - 2007 DA - 2007 May 10 SP - 1882 EP - 1890 VL - 25 IS - 14 KW - Antineoplastic Agents KW - 0 KW - Antineoplastic Agents, Hormonal KW - Aromatase Inhibitors KW - Index Medicus KW - Disease-Free Survival KW - Combined Modality Therapy KW - Humans KW - Clinical Trials as Topic KW - Quality of Life KW - Patient Selection KW - Geriatric Assessment KW - Mass Screening KW - Radiotherapy, Adjuvant KW - Survival Rate KW - Life Expectancy KW - Aromatase Inhibitors -- therapeutic use KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents, Hormonal -- therapeutic use KW - Chemotherapy, Adjuvant KW - Female KW - Breast Neoplasms -- therapy KW - Aged KW - Breast Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70468559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Breast+cancer+in+the+elderly.&rft.au=Crivellari%2C+Diana%3BAapro%2C+Matti%3BLeonard%2C+Robert%3Bvon+Minckwitz%2C+Gunter%3BBrain%2C+Etienne%3BGoldhirsch%2C+Aron%3BVeronesi%2C+Andrea%3BMuss%2C+Hyman&rft.aulast=Crivellari&rft.aufirst=Diana&rft.date=2007-05-10&rft.volume=25&rft.issue=14&rft.spage=1882&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-05 N1 - Date created - 2007-05-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Clin Oncol. 2007 Oct 1;25(28):4501-2; author reply 4502-3 [17906215] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - CCR2 and CCR7 Regulate B16 Murine Melanoma Cell Tumorigenesis in Skin T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39505713; 4626825 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Fang, L AU - Hwang, S T Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Melanoma KW - Skin KW - CC chemokine receptors KW - Monocyte chemoattractant protein 1 KW - CCR2 protein KW - Tumorigenesis KW - CCR7 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39505713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=CCR2+and+CCR7+Regulate+B16+Murine+Melanoma+Cell+Tumorigenesis+in+Skin&rft.au=Fang%2C+L%3BHwang%2C+S+T&rft.aulast=Fang&rft.aufirst=L&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Patients with Defects in the Interacting Nucleotide Excision Repair Proteins ERCC1 or XPF Show Xeroderma Pigmentosum with Late Onset Severe Neurological Degeneration T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39499370; 4626621 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Imoto, K AU - Boyle, J AU - Oh, K. AU - Khan, S AU - Ueda, T AU - Nadem, C AU - Slor, H AU - Orgal, S AU - Gadoth, N AU - Busch, D. (deceased) AU - Jaspers, N G AU - Tamura, D AU - DiGiovanna, J J AU - Kraemer, K H Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Xeroderma pigmentosum KW - Degeneration KW - ERCC1 protein KW - Nucleotide excision repair KW - Defects KW - Nucleotides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39499370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=Patients+with+Defects+in+the+Interacting+Nucleotide+Excision+Repair+Proteins+ERCC1+or+XPF+Show+Xeroderma+Pigmentosum+with+Late+Onset+Severe+Neurological+Degeneration&rft.au=Imoto%2C+K%3BBoyle%2C+J%3BOh%2C+K.%3BKhan%2C+S%3BUeda%2C+T%3BNadem%2C+C%3BSlor%2C+H%3BOrgal%2C+S%3BGadoth%2C+N%3BBusch%2C+D.+%28deceased%29%3BJaspers%2C+N+G%3BTamura%2C+D%3BDiGiovanna%2C+J+J%3BKraemer%2C+K+H&rft.aulast=Imoto&rft.aufirst=K&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Features of Both Xeroderma Pigmentosum and Trichothiodystrophy Presenting in Patients with Mutations in the XPD Gene T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39448474; 4626703 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Rao, T AU - DiGiovanna, J J AU - Tamura, D AU - Ueda, T AU - Boyle, J AU - Nadem, C AU - Oh, K. AU - Khan, S AU - Patronas, N AU - Schiffmann, R AU - Brooks, B P AU - Kraemer, K H Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Mutation KW - XPD protein KW - Trichothiodystrophy KW - Xeroderma pigmentosum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39448474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=Features+of+Both+Xeroderma+Pigmentosum+and+Trichothiodystrophy+Presenting+in+Patients+with+Mutations+in+the+XPD+Gene&rft.au=Rao%2C+T%3BDiGiovanna%2C+J+J%3BTamura%2C+D%3BUeda%2C+T%3BBoyle%2C+J%3BNadem%2C+C%3BOh%2C+K.%3BKhan%2C+S%3BPatronas%2C+N%3BSchiffmann%2C+R%3BBrooks%2C+B+P%3BKraemer%2C+K+H&rft.aulast=Rao&rft.aufirst=T&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Dlx3 in the Regulation of Cell Cycle Proteins T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39447970; 4626565 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Pietroni, V AU - Rivera, Y AU - Radoja, N AU - Stimpson, S AU - Anderson, D E AU - Blumenberg, M AU - Morasso, M Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Cell cycle KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39447970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=Role+of+Dlx3+in+the+Regulation+of+Cell+Cycle+Proteins&rft.au=Pietroni%2C+V%3BRivera%2C+Y%3BRadoja%2C+N%3BStimpson%2C+S%3BAnderson%2C+D+E%3BBlumenberg%2C+M%3BMorasso%2C+M&rft.aulast=Pietroni&rft.aufirst=V&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dermal Infiltration of Monocytes, but not Neutrophils, is Required for the Generation of Contact Hypersensitivity T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39428213; 4626809 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Takeuchi, S AU - Takeuchi, F AU - Furue, M AU - Katz, S I Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Hypersensitivity KW - Infiltration KW - Contact dermatitis KW - Monocytes KW - Skin KW - Leukocytes (neutrophilic) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39428213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=Dermal+Infiltration+of+Monocytes%2C+but+not+Neutrophils%2C+is+Required+for+the+Generation+of+Contact+Hypersensitivity&rft.au=Takeuchi%2C+S%3BTakeuchi%2C+F%3BFurue%2C+M%3BKatz%2C+S+I&rft.aulast=Takeuchi&rft.aufirst=S&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IL-15 Serves as a Co-Stimulator in Determining the Activity of Autoreactive CD8 Tcells in an Experimental Mouse Model of Graft vs. Host Disease (GvHD) T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39428096; 4626770 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Miyagawa, F AU - Tagaya, Y AU - Waldmann, T A AU - Katz, S I Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Animal models KW - Graft-versus-host reaction KW - CD8 antigen KW - Interleukin 15 KW - Hosts KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39428096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=IL-15+Serves+as+a+Co-Stimulator+in+Determining+the+Activity+of+Autoreactive+CD8+Tcells+in+an+Experimental+Mouse+Model+of+Graft+vs.+Host+Disease+%28GvHD%29&rft.au=Miyagawa%2C+F%3BTagaya%2C+Y%3BWaldmann%2C+T+A%3BKatz%2C+S+I&rft.aulast=Miyagawa&rft.aufirst=F&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Epidermal-Specific Deletion of GATA-3 Results in Selective Barrier Deficiency T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39426769; 4626647 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - de Guzman Strong, C AU - Patel, S AU - Wertz, P W AU - Wang, C AU - Yang, F AU - Meltzer, P S AU - Andl, T AU - Millar, S E AU - Ho, I. AU - Pai, S AU - Segre, J A Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - GATA-3 protein KW - Barriers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39426769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=Epidermal-Specific+Deletion+of+GATA-3+Results+in+Selective+Barrier+Deficiency&rft.au=de+Guzman+Strong%2C+C%3BPatel%2C+S%3BWertz%2C+P+W%3BWang%2C+C%3BYang%2C+F%3BMeltzer%2C+P+S%3BAndl%2C+T%3BMillar%2C+S+E%3BHo%2C+I.%3BPai%2C+S%3BSegre%2C+J+A&rft.aulast=de+Guzman+Strong&rft.aufirst=C&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Trichothiodystrophy Includes a Broad Spectrum of Multisystem Abnormalities and May Have a High Mortality at a Young Age T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39423346; 4626704 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Faghri, S AU - DiGiovanna, J J AU - Tamura, D AU - Kraemer, K H Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Mortality KW - Trichothiodystrophy KW - Age KW - Abnormalities KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39423346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=Trichothiodystrophy+Includes+a+Broad+Spectrum+of+Multisystem+Abnormalities+and+May+Have+a+High+Mortality+at+a+Young+Age&rft.au=Faghri%2C+S%3BDiGiovanna%2C+J+J%3BTamura%2C+D%3BKraemer%2C+K+H&rft.aulast=Faghri&rft.aufirst=S&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - UV Signature Mutations in Melanomas from Xeroderma Pigmentosum Patients T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39423132; 4626976 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Wang, Y AU - DiGiovanna, J AU - Stern, J B AU - Hornyak, T AU - Raffeld, M AU - Kraemer, K H Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Melanoma KW - Mutation KW - Xeroderma pigmentosum KW - U.V. radiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39423132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=UV+Signature+Mutations+in+Melanomas+from+Xeroderma+Pigmentosum+Patients&rft.au=Wang%2C+Y%3BDiGiovanna%2C+J%3BStern%2C+J+B%3BHornyak%2C+T%3BRaffeld%2C+M%3BKraemer%2C+K+H&rft.aulast=Wang&rft.aufirst=Y&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proteomic Characterization of Molecular Signatures for Keratinocyte Stem Cells, Transit Amplifying Keratinocytes and Melanocytes in Human Epidermis T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39422158; 4626550 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Terunuma, A AU - Patel, G AU - Blonder, J AU - Kapoor, V AU - Telford, W AU - Veenstra, T AU - Vogel, J Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Stem cells KW - Keratinocytes KW - Proteomics KW - Epidermis KW - Melanocytes KW - Skin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39422158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=Proteomic+Characterization+of+Molecular+Signatures+for+Keratinocyte+Stem+Cells%2C+Transit+Amplifying+Keratinocytes+and+Melanocytes+in+Human+Epidermis&rft.au=Terunuma%2C+A%3BPatel%2C+G%3BBlonder%2C+J%3BKapoor%2C+V%3BTelford%2C+W%3BVeenstra%2C+T%3BVogel%2C+J&rft.aulast=Terunuma&rft.aufirst=A&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Influence of XPB Helicase on Post-UV Recruitment and Redistribution of Nucleotide Excision Repair Proteins and Histone H2AX and ATM Phosphorylation in XP-B Cells T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39419447; 4626915 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Oh, K S AU - Kim, Y S AU - Bustin, M AU - Kraemer, K H Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Recruitment KW - DNA helicase KW - Histone H2A KW - Phosphorylation KW - Nucleotide excision repair KW - Histones KW - Nucleotides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39419447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=Influence+of+XPB+Helicase+on+Post-UV+Recruitment+and+Redistribution+of+Nucleotide+Excision+Repair+Proteins+and+Histone+H2AX+and+ATM+Phosphorylation+in+XP-B+Cells&rft.au=Oh%2C+K+S%3BKim%2C+Y+S%3BBustin%2C+M%3BKraemer%2C+K+H&rft.aulast=Oh&rft.aufirst=K&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Langerhans Cells Represent the Predominant Source of MFG-E8 in Skin T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39418849; 4626797 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Nagao, K AU - Neutzner, M AU - Leitner, W W AU - Sardy, M AU - Lu, M. AU - Clausen, B E AU - Udey, M C Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Skin KW - Langerhans cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39418849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=Langerhans+Cells+Represent+the+Predominant+Source+of+MFG-E8+in+Skin&rft.au=Nagao%2C+K%3BNeutzner%2C+M%3BLeitner%2C+W+W%3BSardy%2C+M%3BLu%2C+M.%3BClausen%2C+B+E%3BUdey%2C+M+C&rft.aulast=Nagao&rft.aufirst=K&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CD4 super(+) Regulatory T Cells Maintain Peripheral Tolerance and Survival in Double Transgenic (K14- sOVA x OT-I) Mice T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39414001; 4626110 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Nograles, K E AU - Miyagawa, F AU - Katz, S I Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Mice KW - Survival KW - Lymphocytes T KW - Immunological tolerance KW - Immunoregulation KW - CD4 antigen KW - Cell survival KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39414001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=CD4+super%28%2B%29+Regulatory+T+Cells+Maintain+Peripheral+Tolerance+and+Survival+in+Double+Transgenic+%28K14-+sOVA+x+OT-I%29+Mice&rft.au=Nograles%2C+K+E%3BMiyagawa%2C+F%3BKatz%2C+S+I&rft.aulast=Nograles&rft.aufirst=K&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inflammation and Skin Cancer Are Linked by Protein Kinase Ca in a Mouse Model for Inducible Cutaneous Inflammation T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39412306; 4626222 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Cataisson, C AU - Ohman, R AU - Pearson, A AU - Tsien, M AU - Hennings, H AU - Yuspa, S H Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Skin cancer KW - Animal models KW - Inflammation KW - Protein kinase C KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39412306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=Inflammation+and+Skin+Cancer+Are+Linked+by+Protein+Kinase+Ca+in+a+Mouse+Model+for+Inducible+Cutaneous+Inflammation&rft.au=Cataisson%2C+C%3BOhman%2C+R%3BPearson%2C+A%3BTsien%2C+M%3BHennings%2C+H%3BYuspa%2C+S+H&rft.aulast=Cataisson&rft.aufirst=C&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mutations within Two Branch Point Sequence (BPS) in an Intron of the XPC Gene Disrupt U2 snRNP - BPS Interaction Resulting in Mild versus Severe XP Phenotypes T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39412251; 4626217 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Khan, S G AU - Yamanegi, K AU - Zheng, Z AU - Boyle, J AU - Imoto, K AU - Oh, K S AU - Armstrong, N AU - Baker, C C AU - Kraemer, K H Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Mutation KW - Introns KW - Ribonucleoproteins (U2 small nuclear) KW - XPC gene KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39412251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=Mutations+within+Two+Branch+Point+Sequence+%28BPS%29+in+an+Intron+of+the+XPC+Gene+Disrupt+U2+snRNP+-+BPS+Interaction+Resulting+in+Mild+versus+Severe+XP+Phenotypes&rft.au=Khan%2C+S+G%3BYamanegi%2C+K%3BZheng%2C+Z%3BBoyle%2C+J%3BImoto%2C+K%3BOh%2C+K+S%3BArmstrong%2C+N%3BBaker%2C+C+C%3BKraemer%2C+K+H&rft.aulast=Khan&rft.aufirst=S&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A CXCR4 Chemokine Receptor Antagonist Enhances Antigen-Specific, adoptive immunotherapy for established B16 melanoma tumors T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39408378; 4626764 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Lee, C AU - Fang, L AU - Palmer, D AU - Restifo, N AU - Hwang, S Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Melanoma KW - Immunotherapy KW - Chemokine receptors KW - Tumors KW - Adoptive immunotherapy KW - CXCR4 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39408378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=A+CXCR4+Chemokine+Receptor+Antagonist+Enhances+Antigen-Specific%2C+adoptive+immunotherapy+for+established+B16+melanoma+tumors&rft.au=Lee%2C+C%3BFang%2C+L%3BPalmer%2C+D%3BRestifo%2C+N%3BHwang%2C+S&rft.aulast=Lee&rft.aufirst=C&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Developing a Tetracycline-Inducible System for Analyzing Dlx3 Function in Mouse Keratinocytes T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39407181; 4626519 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Lee, D AU - Duverger, O AU - Jaisser, F AU - Morasso, M Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Keratinocytes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39407181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=Developing+a+Tetracycline-Inducible+System+for+Analyzing+Dlx3+Function+in+Mouse+Keratinocytes&rft.au=Lee%2C+D%3BDuverger%2C+O%3BJaisser%2C+F%3BMorasso%2C+M&rft.aulast=Lee&rft.aufirst=D&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Correlations Among Different Types of Skin Lesions and Internal Organ Involvement in Tuberous Sclerosis Complex T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39389441; 4626354 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Hong, C AU - Takeuchi, F AU - Aldrich, S AU - Hathaway, L AU - Moss, J AU - Lee, C AU - Darling, T N Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Organs KW - Skin diseases KW - Lesions KW - Tuberous sclerosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39389441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=Correlations+Among+Different+Types+of+Skin+Lesions+and+Internal+Organ+Involvement+in+Tuberous+Sclerosis+Complex&rft.au=Hong%2C+C%3BTakeuchi%2C+F%3BAldrich%2C+S%3BHathaway%2C+L%3BMoss%2C+J%3BLee%2C+C%3BDarling%2C+T+N&rft.aulast=Hong&rft.aufirst=C&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effects of Dickkopf 1 on Gene Expression and Wnt Signaling by Keratinocytes: Mechanisms Regulating Skin Pigmentation and Thickness T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39386153; 4626944 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Yamaguchi, Y AU - Passeron, T AU - Katayama, I AU - Hearing, V J Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Pigmentation KW - Skin KW - Signal transduction KW - Wnt protein KW - Gene expression KW - Dkk1 protein KW - Keratinocytes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39386153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=The+Effects+of+Dickkopf+1+on+Gene+Expression+and+Wnt+Signaling+by+Keratinocytes%3A+Mechanisms+Regulating+Skin+Pigmentation+and+Thickness&rft.au=Yamaguchi%2C+Y%3BPasseron%2C+T%3BKatayama%2C+I%3BHearing%2C+V+J&rft.aulast=Yamaguchi&rft.aufirst=Y&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dlx3 Gene Expression in lacZ Knock-In Mice and its Function in Hair Development T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39380432; 4626709 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Hwang, J AU - Morasso, M Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Mice KW - Hair KW - Dlx3 gene KW - Gene expression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39380432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=Dlx3+Gene+Expression+in+lacZ+Knock-In+Mice+and+its+Function+in+Hair+Development&rft.au=Hwang%2C+J%3BMorasso%2C+M&rft.aulast=Hwang&rft.aufirst=J&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inheritance Pattern in Familial Keloids T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39374475; 4626639 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Clark, J AU - Turner, M L AU - Kopp, J B Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Heredity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39374475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=Inheritance+Pattern+in+Familial+Keloids&rft.au=Clark%2C+J%3BTurner%2C+M+L%3BKopp%2C+J+B&rft.aulast=Clark&rft.aufirst=J&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enhancement of DNA Vaccine Efficacy by Simple Gene Gun Mediated Co-Delivery of Minute Amounts of a Plasmid-Encoded Helper Antigen T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39373746; 4626793 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Leitner, W W AU - Baker, M C AU - Yannie, J P AU - Udey, M C Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Vaccines KW - DNA vaccines KW - Antigens KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39373746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=Enhancement+of+DNA+Vaccine+Efficacy+by+Simple+Gene+Gun+Mediated+Co-Delivery+of+Minute+Amounts+of+a+Plasmid-Encoded+Helper+Antigen&rft.au=Leitner%2C+W+W%3BBaker%2C+M+C%3BYannie%2C+J+P%3BUdey%2C+M+C&rft.aulast=Leitner&rft.aufirst=W&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Granulocyte-Macrophage Colony-Stimulating Factor Expression is Regulated by Epidermal Growth Factor Receptor Pathway T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39368241; 4626655 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Mascia, F AU - Mariani, V AU - Cataisson, C AU - Yuspa, S AU - Pastore, S Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Growth factors KW - Granulocyte-macrophage colony-stimulating factor KW - Epidermal growth factor receptors KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39368241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=Granulocyte-Macrophage+Colony-Stimulating+Factor+Expression+is+Regulated+by+Epidermal+Growth+Factor+Receptor+Pathway&rft.au=Mascia%2C+F%3BMariani%2C+V%3BCataisson%2C+C%3BYuspa%2C+S%3BPastore%2C+S&rft.aulast=Mascia&rft.aufirst=F&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differentiation of Tumor-Phase Mycosis Fungoides, Psoriasis Vulgaris, and Normal Controls in a Pilot Study using Serum Proteomic Analysis T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39363008; 4626304 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Cowen, E W AU - Liu, C AU - Steinberg, S M AU - Kang, S AU - Vonderheid, E C AU - Kwak, H AU - Booher, S AU - Petricoin, E F AU - Liotta, L A AU - Hwang, S T Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Psoriasis vulgaris KW - Proteomics KW - Mycosis fungoides KW - Differentiation KW - Serum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39363008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=Differentiation+of+Tumor-Phase+Mycosis+Fungoides%2C+Psoriasis+Vulgaris%2C+and+Normal+Controls+in+a+Pilot+Study+using+Serum+Proteomic+Analysis&rft.au=Cowen%2C+E+W%3BLiu%2C+C%3BSteinberg%2C+S+M%3BKang%2C+S%3BVonderheid%2C+E+C%3BKwak%2C+H%3BBooher%2C+S%3BPetricoin%2C+E+F%3BLiotta%2C+L+A%3BHwang%2C+S+T&rft.aulast=Cowen&rft.aufirst=E&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Highly Similar S100A7/ S100A15 Paralogs are Differentially Expressed in Normal Skin and Inflamed Psoriasis and Function as Chemotactic Proteins T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39358613; 4626144 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Wolf, R AU - Dong, H AU - Voscopoulos, C AU - Cataisson, C AU - Mascia, F AU - Winston, J AU - Goldsmith, P AU - FitzGerald, P AU - Howard, Z AU - Yuspa, S H Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Skin KW - Psoriasis KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39358613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=The+Highly+Similar+S100A7%2F+S100A15+Paralogs+are+Differentially+Expressed+in+Normal+Skin+and+Inflamed+Psoriasis+and+Function+as+Chemotactic+Proteins&rft.au=Wolf%2C+R%3BDong%2C+H%3BVoscopoulos%2C+C%3BCataisson%2C+C%3BMascia%2C+F%3BWinston%2C+J%3BGoldsmith%2C+P%3BFitzGerald%2C+P%3BHoward%2C+Z%3BYuspa%2C+S+H&rft.aulast=Wolf&rft.aufirst=R&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ca++-Binding Protein Scarf Function during Epidermal Development T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39357264; 4626523 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Kalinin, O AU - Hwang, J AU - Hwang, M AU - Morasso, M I Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Calcium-binding protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39357264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=Ca%2B%2B-Binding+Protein+Scarf+Function+during+Epidermal+Development&rft.au=Kalinin%2C+O%3BHwang%2C+J%3BHwang%2C+M%3BMorasso%2C+M+I&rft.aulast=Kalinin&rft.aufirst=O&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chronic UVA Irradiation of Human HaCaT Keratinocytes Induces Malignant Transformation: Role of PI3K/PTEN/AKT Signaling T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39356166; 4626191 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - He, Y. AU - Pi, J. AU - Huang, J AU - Diwan, B A AU - Waalkes, M P AU - Chignell, C F Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Irradiation KW - Signal transduction KW - U.V. radiation KW - 1-Phosphatidylinositol 3-kinase KW - PTEN protein KW - AKT protein KW - Keratinocytes KW - Transformation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39356166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=Chronic+UVA+Irradiation+of+Human+HaCaT+Keratinocytes+Induces+Malignant+Transformation%3A+Role+of+PI3K%2FPTEN%2FAKT+Signaling&rft.au=He%2C+Y.%3BPi%2C+J.%3BHuang%2C+J%3BDiwan%2C+B+A%3BWaalkes%2C+M+P%3BChignell%2C+C+F&rft.aulast=He&rft.aufirst=Y.&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Study of the Functional Alterations in the Mutated DLX3 Isoform Responsible for Tricho-Dento- Osseous Syndrome T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39319174; 4626625 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Duverger, O AU - Lee, D AU - Morasso, M Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39319174?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=Study+of+the+Functional+Alterations+in+the+Mutated+DLX3+Isoform+Responsible+for+Tricho-Dento-+Osseous+Syndrome&rft.au=Duverger%2C+O%3BLee%2C+D%3BMorasso%2C+M&rft.aulast=Duverger&rft.aufirst=O&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Skin Gene Therapy: Systemic Delivery of the Anti-Hypertensive Atrial Natriuretic Peptide (ANP) by Genetically-Modified Human Skin Equivalents (HSE) T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39319118; 4626615 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Therrien, J AU - Terunuma, A AU - Tock, C L AU - Pfuztner, W AU - Ohyama, M AU - Vogel, J C Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Skin KW - Atrial natriuretic peptide KW - Gene therapy KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39319118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=Skin+Gene+Therapy%3A+Systemic+Delivery+of+the+Anti-Hypertensive+Atrial+Natriuretic+Peptide+%28ANP%29+by+Genetically-Modified+Human+Skin+Equivalents+%28HSE%29&rft.au=Therrien%2C+J%3BTerunuma%2C+A%3BTock%2C+C+L%3BPfuztner%2C+W%3BOhyama%2C+M%3BVogel%2C+J+C&rft.aulast=Therrien&rft.aufirst=J&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Accumulation of CCL27 Protein in Skin-Draining Lymph Node (LN) in the Absence of CCL27 Transcription may Contribute to CCR10-Mediated Nodal Metastasis T2 - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AN - 39312060; 4626227 JF - 68th Annual Meeting of the Society for Investigative Dermatology (SID 2007) AU - Huang, V AU - Kakinuma, T AU - Murakami, T AU - Huang, S Y1 - 2007/05/09/ PY - 2007 DA - 2007 May 09 KW - Lymph nodes KW - Transcription KW - Skin KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39312060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.atitle=Accumulation+of+CCL27+Protein+in+Skin-Draining+Lymph+Node+%28LN%29+in+the+Absence+of+CCL27+Transcription+may+Contribute+to+CCR10-Mediated+Nodal+Metastasis&rft.au=Huang%2C+V%3BKakinuma%2C+T%3BMurakami%2C+T%3BHuang%2C+S&rft.aulast=Huang&rft.aufirst=V&rft.date=2007-05-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=68th+Annual+Meeting+of+the+Society+for+Investigative+Dermatology+%28SID+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.nature.com/jid/journal/v127/n1s/pdf/5700832a.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Benign prostatic hyperplasia and subsequent risk of bladder cancer AN - 954575437; 13759954 AB - We evaluated the risk of bladder cancer in a cohort of 79280 Swedish men hospitalised for benign prostatic hyperplasia (BPH), identified in the Swedish Inpatient Register between 1964 and 1983 and followed until 1989 via multiple record linkages with nationwide data on cancer registry, death and emigration. Standardised incidence ratios (SIRs), the ratios of the observed to the expected numbers of incident bladder cancers, were used to calculate the risk associated with BPH. The expected number was calculated by multiplying the number of person-years by the age-specific cancer incidence rates in Sweden for each 5-year age group and calendar year of observation. Analyses were stratified by BPH treatment, latency, calendar year and presence of genitourinary (GU) comorbid conditions. After excluding the first 3 years of follow-up after the index hospitalisation, we observed 506 incident bladder cancer cases during follow-up in the cohort. No overall increased risk of bladder cancer was apparent in our main analysis involving the entire BPH cohort. However, among BPH patients with transurethral resection of the prostate (TURP), there was an increased risk in all follow-up periods; SIRs of bladder cancer during years 4-6 of follow-up was 1.22 (95% confidence interval=1.02-1.46), 1.32 for 7-9 years of follow-up, and 1.47 for 10-26 years of follow-up. SIRs of bladder cancer among TURP-treated BPH patients were particularly elevated among those with comorbid conditions of the GU tract (e.g., stone, infection, etc.); 1.72, 1.74 and 2.01 for 4-6, 7-9, 10-26 years of follow-up, respectively, and also for those whose diagnoses occurred before 1975, when TURP was more likely to be performed by a urologist than a general practitioner: 1.87, 1.90 and 1.74, respectively. These findings suggest that BPH overall is not associated with bladder cancer risk. However, among men treated with TURP, particularly those with other comorbid GU tract conditions, risk of bladder cancer was elevated.British Journal of Cancer (2007) 96, 1475-1479. doi:10.1038/sj.bjc.6603730 www.bjcancer.com Published online 1 May 2007 JF - British Journal of Cancer AU - Kang, D AU - Chokkalingam, A P AU - Gridley, G AU - Nyren, O AU - Johansson, J E AU - Adami, H O AU - Silverman, D AU - Hsing, A W AD - [1] 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA [2] 2 College of Medicine, Seoul National University, Seoul, Korea Y1 - 2007/05/07/ PY - 2007 DA - 2007 May 07 SP - 1475 EP - 1479 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 96 IS - 9 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - urinary bladder KW - Mortality KW - Age KW - infection KW - emigration KW - Cancer KW - Sweden KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954575437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Benign+prostatic+hyperplasia+and+subsequent+risk+of+bladder+cancer&rft.au=Kang%2C+D%3BChokkalingam%2C+A+P%3BGridley%2C+G%3BNyren%2C+O%3BJohansson%2C+J+E%3BAdami%2C+H+O%3BSilverman%2C+D%3BHsing%2C+A+W&rft.aulast=Kang&rft.aufirst=D&rft.date=2007-05-07&rft.volume=96&rft.issue=9&rft.spage=1475&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6603730 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2014-05-29 N1 - SubjectsTermNotLitGenreText - Mortality; urinary bladder; Age; infection; emigration; Cancer; Sweden DO - http://dx.doi.org/10.1038/sj.bjc.6603730 ER - TY - JOUR T1 - Alcohol and head and neck cancer risk in a prospective study AN - 954574413; 13759946 AB - We investigated the relation between head and neck cancer risk and alcohol consumption in the NIH-AARP Diet and Health Study. During 2203500 person-years of follow-up, 611 men and 183 women developed head and neck cancer. With moderate drinking (up to one alcoholic drink per day) as the referent group, non-drinkers showed an increased risk of head and neck cancer (men: hazard ratio (HR) 1.68, 95% confidence interval (95% CI) 1.37-2.06; women: 1.46, 1.02-2.08). Among male and female alcohol drinkers, we observed a significant dose-response relationship between alcohol consumption and risk. The HR for consuming >3 drinks per day was significantly higher in women (2.52, 1.46-4.35) than in men (1.48, 1.15-1.90; P for interaction=0.0036). The incidence rates per 100000 person-years for those who consumed >3 drinks per day were similar in men (77.6) and women (75.3). The higher HRs observed in women resulted from lower incidence rates in the referent group: women (14.7), men (34.4). In summary, drinking >3 alcoholic beverages per day was associated with increased risk in men and women, but consumption of up to one drink per day may be associated with reduced risk relative to non-drinking.British Journal of Cancer (2007) 96, 1469-1474. doi:10.1038/sj.bjc.6603713 www.bjcancer.com Published online 27 March 2007 JF - British Journal of Cancer AU - Freedman, N D AU - Schatzkin, A AU - Leitzmann, M F AU - Hollenbeck, A R AU - Abnet, C C AD - 1 Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Executive Plaza North, Suite 3109, 6130 Executive Boulevard, MSC 7361, Bethesda, MD 20892-7361, USA Y1 - 2007/05/07/ PY - 2007 DA - 2007 May 07 SP - 1469 EP - 1474 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 96 IS - 9 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - Diets KW - Alcohol KW - risk reduction KW - Dose-response effects KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954574413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Alcohol+and+head+and+neck+cancer+risk+in+a+prospective+study&rft.au=Freedman%2C+N+D%3BSchatzkin%2C+A%3BLeitzmann%2C+M+F%3BHollenbeck%2C+A+R%3BAbnet%2C+C+C&rft.aulast=Freedman&rft.aufirst=N&rft.date=2007-05-07&rft.volume=96&rft.issue=9&rft.spage=1469&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6603713 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Diets; risk reduction; Alcohol; Dose-response effects; Cancer DO - http://dx.doi.org/10.1038/sj.bjc.6603713 ER - TY - JOUR T1 - Reproductive risk factors for endometrial cancer among Polish women AN - 899130210; 13759955 AB - We conducted a population-based case-control study of reproductive factors in Warsaw and Loz, Poland, in 551 incident endometrial cancer cases and 1925 controls. The reproductive variable most strongly related to risk was multiparity, with subjects with three or more births having a 70% lower risk than the nulliparous women. The reduced risk was particularly strong below 55 years of age. Subjects with older ages at a first birth were also at reduced risk even after adjustment for number of births. Ages at last birth or intervals since last birth were not strongly related to risk. Spontaneous abortions were unrelated to risk, but induced abortions were associated with slight risk increases (odds ratios=1.28, 95% confidence intervals 0.8-2.1 for 3+ vs no abortions). The absence of effects on risk of later ages at, or short intervals since, a last birth fails to support the view that endometrial cancer is influenced by mechanical clearance of initiated cells. Alternative explanations for reproductive effects should be sought, including alterations in endogenous hormones.British Journal of Cancer (2007) 96, 1450-1456. doi:10.1038/sj.bjc.6603731 www.bjcancer.com Published online 10 April 2007 JF - British Journal of Cancer AU - Brinton, L A AU - Sakoda, L C AU - Lissowska, J AU - Sherman, M E AU - Chatterjee, N AU - Peplonska, B AU - Szeszenia-Dabrowska, N AU - Zatonski, W AU - Garcia-Closas, M AD - 1 Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., Suite 550, Rockville, MD 20852-7234, USA Y1 - 2007/05/07/ PY - 2007 DA - 2007 May 07 SP - 1450 EP - 1456 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 96 IS - 9 SN - 0007-0920, 0007-0920 KW - Risk Abstracts KW - risk reduction KW - Age KW - Poland KW - Abortion KW - Females KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/899130210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Reproductive+risk+factors+for+endometrial+cancer+among+Polish+women&rft.au=Brinton%2C+L+A%3BSakoda%2C+L+C%3BLissowska%2C+J%3BSherman%2C+M+E%3BChatterjee%2C+N%3BPeplonska%2C+B%3BSzeszenia-Dabrowska%2C+N%3BZatonski%2C+W%3BGarcia-Closas%2C+M&rft.aulast=Brinton&rft.aufirst=L&rft.date=2007-05-07&rft.volume=96&rft.issue=9&rft.spage=1450&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6603731 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - risk reduction; Age; Abortion; Females; Cancer; Poland DO - http://dx.doi.org/10.1038/sj.bjc.6603731 ER - TY - CPAPER T1 - Crystallin Modulation of Caspases T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40658489; 4573781 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Wawrousek, E F Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Caspase KW - Crystallin KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40658489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Crystallin+Modulation+of+Caspases&rft.au=Wawrousek%2C+E+F&rft.aulast=Wawrousek&rft.aufirst=E&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - AREDS2 with Lutein/Zeaxanthin and Omega-3 Fatty Acids: Update T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40658081; 4573812 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Chew, E Y Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Fatty acids KW - Zeaxanthin KW - Lutein KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40658081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=AREDS2+with+Lutein%2FZeaxanthin+and+Omega-3+Fatty+Acids%3A+Update&rft.au=Chew%2C+E+Y&rft.aulast=Chew&rft.aufirst=E&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Membrane-bound Carbonic Anhydrases in Cultured Human Fetal Retinal Pigment Epithelial Cells (hfRPE) T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40656676; 4573751 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Miller, S Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Pigments KW - Carbonic anhydrase KW - Retinal pigment epithelium KW - Fetuses KW - Retina KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40656676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Membrane-bound+Carbonic+Anhydrases+in+Cultured+Human+Fetal+Retinal+Pigment+Epithelial+Cells+%28hfRPE%29&rft.au=Miller%2C+S&rft.aulast=Miller&rft.aufirst=S&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Voltage Sensitive Channels and Intracellular Calcium Dynamics in A17 Amacrine Cells T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40655054; 4573706 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Grimes, W N AU - Diamond, J S Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Channels KW - Calcium (intracellular) KW - Calcium channels (voltage-gated) KW - Amacrine cells KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40655054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Voltage+Sensitive+Channels+and+Intracellular+Calcium+Dynamics+in+A17+Amacrine+Cells&rft.au=Grimes%2C+W+N%3BDiamond%2C+J+S&rft.aulast=Grimes&rft.aufirst=W&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression of Olfactomedin 1 Promotes Neurogenesis and May Reverse Hypermethylation of Some Promoters in PC12 Cells T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40654852; 4573647 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Lee, H.-S. AU - Nakaya, N AU - Tomarev, S I Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Neurogenesis KW - Pheochromocytoma cells KW - Promoters KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40654852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Expression+of+Olfactomedin+1+Promotes+Neurogenesis+and+May+Reverse+Hypermethylation+of+Some+Promoters+in+PC12+Cells&rft.au=Lee%2C+H.-S.%3BNakaya%2C+N%3BTomarev%2C+S+I&rft.aulast=Lee&rft.aufirst=H.-S.&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Murine Models of Intraocular Lymphoma T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40654817; 4573764 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Chan, C.-C. Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Lymphoma KW - Animal models KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40654817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Murine+Models+of+Intraocular+Lymphoma&rft.au=Chan%2C+C.-C.&rft.aulast=Chan&rft.aufirst=C.-C.&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clinical Features of Autoimmune Retinopathy Associated with Anti-Retinal Antibodies T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40651113; 4571672 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Yeh, S AU - Chin, M S AU - Jirawuthiworavong, G AU - Caruso, R C AU - Lew, J C AU - Kurup, S K AU - Hooks, J J AU - Nussenblatt, R B AU - Levy-Clarke, G A Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Retinopathy KW - Antibodies KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40651113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Clinical+Features+of+Autoimmune+Retinopathy+Associated+with+Anti-Retinal+Antibodies&rft.au=Yeh%2C+S%3BChin%2C+M+S%3BJirawuthiworavong%2C+G%3BCaruso%2C+R+C%3BLew%2C+J+C%3BKurup%2C+S+K%3BHooks%2C+J+J%3BNussenblatt%2C+R+B%3BLevy-Clarke%2C+G+A&rft.aulast=Yeh&rft.aufirst=S&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Chemical Chaperones on Secretion and Cleavage of Wild Type and Mutated Human and Mouse Myocilin T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40650962; 4573645 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Kwon, H AU - Lee, H AU - Tomarev, S I Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Secretion KW - Chaperones KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40650962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Effects+of+Chemical+Chaperones+on+Secretion+and+Cleavage+of+Wild+Type+and+Mutated+Human+and+Mouse+Myocilin&rft.au=Kwon%2C+H%3BLee%2C+H%3BTomarev%2C+S+I&rft.aulast=Kwon&rft.aufirst=H&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Aging on the Normal Human Electro-Oculogram T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40648281; 4571687 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Lopez, P AU - Reuter, L M AU - Caruso, R C Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Aging KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40648281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Effect+of+Aging+on+the+Normal+Human+Electro-Oculogram&rft.au=Lopez%2C+P%3BReuter%2C+L+M%3BCaruso%2C+R+C&rft.aulast=Lopez&rft.aufirst=P&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microperimetry in Patients with Macular Disease: Adjusting for Location of Preferred Retinal Fixation Locus T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40647279; 4572086 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Caruso, R C AU - Lopez, P AU - Reuter, L M Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Retina KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40647279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Microperimetry+in+Patients+with+Macular+Disease%3A+Adjusting+for+Location+of+Preferred+Retinal+Fixation+Locus&rft.au=Caruso%2C+R+C%3BLopez%2C+P%3BReuter%2C+L+M&rft.aulast=Caruso&rft.aufirst=R&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IFNg Inhibits Cell Proliferation and Migration in Human Fetal Retinal Pigment Epithelium (hfRPE) T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40647081; 4573468 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Li, R. AU - Maminishkis, A AU - Banzon, T AU - Miller, S S Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Pigments KW - Retinal pigment epithelium KW - Cell proliferation KW - Fetuses KW - Cell migration KW - Retina KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40647081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=IFNg+Inhibits+Cell+Proliferation+and+Migration+in+Human+Fetal+Retinal+Pigment+Epithelium+%28hfRPE%29&rft.au=Li%2C+R.%3BMaminishkis%2C+A%3BBanzon%2C+T%3BMiller%2C+S+S&rft.aulast=Li&rft.aufirst=R.&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Pathogenesis of Papillo-Renal Syndrome T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40646269; 4571775 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Alur, R P AU - Brown, J D AU - Gong, X AU - Brooks, B P Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Symptoms KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40646269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Molecular+Pathogenesis+of+Papillo-Renal+Syndrome&rft.au=Alur%2C+R+P%3BBrown%2C+J+D%3BGong%2C+X%3BBrooks%2C+B+P&rft.aulast=Alur&rft.aufirst=R&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mutation Spectrum of the CHM Gene in Patients with Choroideremia T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40644937; 4571715 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Smaoui, N AU - McGee, T L AU - Nwokekeh, N AU - Weigel-DiFranco, C AU - Rosner, B AU - Hejtmancik, J F AU - Berson, E L Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Mutation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40644937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Mutation+Spectrum+of+the+CHM+Gene+in+Patients+with+Choroideremia&rft.au=Smaoui%2C+N%3BMcGee%2C+T+L%3BNwokekeh%2C+N%3BWeigel-DiFranco%2C+C%3BRosner%2C+B%3BHejtmancik%2C+J+F%3BBerson%2C+E+L&rft.aulast=Smaoui&rft.aufirst=N&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interactions between Pigment Epithelium-Derived Factor (PEDF) and F1 ATP Synthase Provide Insights into its Antiangiogenic Mechanism T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40643764; 4571075 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Becerra, S AU - Amaral, J AU - Notari, L Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Pigments KW - Pigment epithelium-derived factor KW - ATP synthase KW - ATP KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40643764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Interactions+between+Pigment+Epithelium-Derived+Factor+%28PEDF%29+and+F1+ATP+Synthase+Provide+Insights+into+its+Antiangiogenic+Mechanism&rft.au=Becerra%2C+S%3BAmaral%2C+J%3BNotari%2C+L&rft.aulast=Becerra&rft.aufirst=S&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Endogenous IL-6 is Needed to Sustain an Efficient Antigen-Specific IL-17 Response in Experimental Autoimmune Uveitis (EAU) T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40642792; 4570794 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Rachitskaya, A AU - Hansen, A M AU - Agarwal, R K AU - Silver, P B AU - Chan, C.-C. AU - Caspi, R R Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Interleukin 17 KW - Experimental autoimmune uveitis KW - Interleukin 6 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40642792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Endogenous+IL-6+is+Needed+to+Sustain+an+Efficient+Antigen-Specific+IL-17+Response+in+Experimental+Autoimmune+Uveitis+%28EAU%29&rft.au=Rachitskaya%2C+A%3BHansen%2C+A+M%3BAgarwal%2C+R+K%3BSilver%2C+P+B%3BChan%2C+C.-C.%3BCaspi%2C+R+R&rft.aulast=Rachitskaya&rft.aufirst=A&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of 7-Ketocholesterol and 7-Ketocholesterol Sulfate in the Primate Retina and its Biological Implications T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40642066; 4572880 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Rodriguez, I R AU - Javitt, N B AU - Lee, J W Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Sulfate KW - Primates KW - Retina KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40642066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Identification+of+7-Ketocholesterol+and+7-Ketocholesterol+Sulfate+in+the+Primate+Retina+and+its+Biological+Implications&rft.au=Rodriguez%2C+I+R%3BJavitt%2C+N+B%3BLee%2C+J+W&rft.aulast=Rodriguez&rft.aufirst=I&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cellular Localization of Peroxiredoxin III in the Primate Retina and Acute Induction in Human RPE Cells T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40641939; 4572849 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Moreira, E F AU - Lee, W AU - Kantorow, M AU - Rodriguez, I R Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Primates KW - Retina KW - Peroxiredoxin KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40641939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Cellular+Localization+of+Peroxiredoxin+III+in+the+Primate+Retina+and+Acute+Induction+in+Human+RPE+Cells&rft.au=Moreira%2C+E+F%3BLee%2C+W%3BKantorow%2C+M%3BRodriguez%2C+I+R&rft.aulast=Moreira&rft.aufirst=E&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression of Clusterin and VEGF in Diabetic Retinopathy T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40641917; 4572779 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Head, J AU - Shen, D AU - Zhou, M AU - Garfinkel, R A AU - Chan, C.-C. Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Retinopathy KW - Clusterin KW - Vascular endothelial growth factor KW - Diabetes mellitus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40641917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Expression+of+Clusterin+and+VEGF+in+Diabetic+Retinopathy&rft.au=Head%2C+J%3BShen%2C+D%3BZhou%2C+M%3BGarfinkel%2C+R+A%3BChan%2C+C.-C.&rft.aulast=Head&rft.aufirst=J&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Thiazolidinediones and Diabetic Macular Edema: Is there an Association? T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40641797; 4569777 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Meyerle, C B AU - Greven, C M AU - Danis, R P AU - Chew, E Y Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Edema KW - Diabetes mellitus KW - Thiazolidinediones KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40641797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Thiazolidinediones+and+Diabetic+Macular+Edema%3A+Is+there+an+Association%3F&rft.au=Meyerle%2C+C+B%3BGreven%2C+C+M%3BDanis%2C+R+P%3BChew%2C+E+Y&rft.aulast=Meyerle&rft.aufirst=C&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of ROS Disk Membrane Phospholipids with Extremely Long Polyunsaturated Acyl Chains on Visual Signalling T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40641445; 4571034 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Mitchell, D C AU - Niu, S.-L. AU - Bennett, M AU - Greeley, L A AU - Hines, K G AU - Andersen, B M Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Membranes KW - Signal transduction KW - Reactive oxygen species KW - Phospholipids KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40641445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Effects+of+ROS+Disk+Membrane+Phospholipids+with+Extremely+Long+Polyunsaturated+Acyl+Chains+on+Visual+Signalling&rft.au=Mitchell%2C+D+C%3BNiu%2C+S.-L.%3BBennett%2C+M%3BGreeley%2C+L+A%3BHines%2C+K+G%3BAndersen%2C+B+M&rft.aulast=Mitchell&rft.aufirst=D&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Membrane-Bound Carbonic Anhydrases in Human Fetal Retinal Pigment Epithelial Cells (hfRPE) T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40641038; 4570697 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Zhi, C G AU - Wang, F E AU - Banzon, T AU - Jalickee, S AU - Fariss, R AU - Maminishkis, A AU - Miller, S S Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Pigments KW - Carbonic anhydrase KW - Retinal pigment epithelium KW - Fetuses KW - Retina KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40641038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Membrane-Bound+Carbonic+Anhydrases+in+Human+Fetal+Retinal+Pigment+Epithelial+Cells+%28hfRPE%29&rft.au=Zhi%2C+C+G%3BWang%2C+F+E%3BBanzon%2C+T%3BJalickee%2C+S%3BFariss%2C+R%3BMaminishkis%2C+A%3BMiller%2C+S+S&rft.aulast=Zhi&rft.aufirst=C&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Subcutaneous Injections of LX211 Prevent and Reverse Experimental Autoimmune Uveoretinitis in Rats T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40640857; 4570805 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Cunningham, M A AU - Li, Z. AU - Chan, C.-C. AU - Liu, B AU - Pantanelli, S AU - Yeh, S AU - Anglade, E AU - Velagaleti, P AU - Trepanier, D AU - Nussenblatt, R B Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Rats KW - Uveoretinitis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40640857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Subcutaneous+Injections+of+LX211+Prevent+and+Reverse+Experimental+Autoimmune+Uveoretinitis+in+Rats&rft.au=Cunningham%2C+M+A%3BLi%2C+Z.%3BChan%2C+C.-C.%3BLiu%2C+B%3BPantanelli%2C+S%3BYeh%2C+S%3BAnglade%2C+E%3BVelagaleti%2C+P%3BTrepanier%2C+D%3BNussenblatt%2C+R+B&rft.aulast=Cunningham&rft.aufirst=M&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Antagonistic Effects of STAT1 and STAT6 on Dendritic Cells (DC): STAT1 Enhances DC Maturation While STAT6 Promotes Production of IL-12 and IL-23 T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40640522; 4573002 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Lee, Y AU - Yu, C.-R. AU - Liu, X AU - Egwuagu, C Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Stat6 protein KW - Stat1 protein KW - Dendritic cells KW - Interleukin 12 KW - Interleukin 23 KW - Sexual maturity KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40640522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Antagonistic+Effects+of+STAT1+and+STAT6+on+Dendritic+Cells+%28DC%29%3A+STAT1+Enhances+DC+Maturation+While+STAT6+Promotes+Production+of+IL-12+and+IL-23&rft.au=Lee%2C+Y%3BYu%2C+C.-R.%3BLiu%2C+X%3BEgwuagu%2C+C&rft.aulast=Lee&rft.aufirst=Y&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Retinoschisin is a Peripheral Membrane Protein with Affinity for Anionic Phospholipids and Affected by Divalent Cations T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40639764; 4572347 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Vijayasarathy, C AU - Takada, Y AU - Zeng, Y AU - Bush, R A AU - Sieving, P A Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Cations KW - Membrane proteins KW - Affinity KW - Phospholipids KW - Anions KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40639764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Retinoschisin+is+a+Peripheral+Membrane+Protein+with+Affinity+for+Anionic+Phospholipids+and+Affected+by+Divalent+Cations&rft.au=Vijayasarathy%2C+C%3BTakada%2C+Y%3BZeng%2C+Y%3BBush%2C+R+A%3BSieving%2C+P+A&rft.aulast=Vijayasarathy&rft.aufirst=C&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparison of Dilated Clinical Fundus Exam using the International Clinical Diabetic Retinopathy Severity (ICDRS) Scale with Standard Stereoscopic Seven-Field Photography using the Early Treatment Diabetic Retinopathy Study (ETDRS) Scale T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40639541; 4569757 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Wong, W T AU - Wilkinson, C P AU - Agron, E AU - Glander, K AU - Davis, M AU - Adler, S AU - Rasooly, R AU - Danis, R AU - Chew, E Y Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Photography KW - International standardization KW - Retinopathy KW - Diabetes mellitus KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40639541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Comparison+of+Dilated+Clinical+Fundus+Exam+using+the+International+Clinical+Diabetic+Retinopathy+Severity+%28ICDRS%29+Scale+with+Standard+Stereoscopic+Seven-Field+Photography+using+the+Early+Treatment+Diabetic+Retinopathy+Study+%28ETDRS%29+Scale&rft.au=Wong%2C+W+T%3BWilkinson%2C+C+P%3BAgron%2C+E%3BGlander%2C+K%3BDavis%2C+M%3BAdler%2C+S%3BRasooly%2C+R%3BDanis%2C+R%3BChew%2C+E+Y&rft.aulast=Wong&rft.aufirst=W&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single Marker Associations of Nuclear-Encoded Mitochondrial Genes with Advanced AMD T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40639463; 4570315 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - SanGiovanni, J P AU - Chew, E Y AU - Clemons, T E AU - Henning, A K AU - Hoh, J AU - Elashoff, M Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Mitochondria KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40639463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Single+Marker+Associations+of+Nuclear-Encoded+Mitochondrial+Genes+with+Advanced+AMD&rft.au=SanGiovanni%2C+J+P%3BChew%2C+E+Y%3BClemons%2C+T+E%3BHenning%2C+A+K%3BHoh%2C+J%3BElashoff%2C+M&rft.aulast=SanGiovanni&rft.aufirst=J&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interferon-g Downregulates IL-1 and TNF-a Induced IL-11 Secretion by Human Retinal Pigment Epithelial Cells T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40639086; 4570689 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Kommineni, V K AU - Nagineni, C N AU - Detrick, B AU - Hooks, J J Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Pigments KW - Retinal pigment epithelium KW - Interleukin 1 KW - Tumor necrosis factor-a KW - G-Interferon KW - Interleukin 11 KW - Secretion KW - Retina KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40639086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Interferon-g+Downregulates+IL-1+and+TNF-a+Induced+IL-11+Secretion+by+Human+Retinal+Pigment+Epithelial+Cells&rft.au=Kommineni%2C+V+K%3BNagineni%2C+C+N%3BDetrick%2C+B%3BHooks%2C+J+J&rft.aulast=Kommineni&rft.aufirst=V&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mutations in bB3-Crystallin, Galk1, Hsf4 are Associated with Autosomal Recessive Cataract in Pakistani Families T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40639044; 4569692 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Jiao, X AU - Yao, W AU - Riazuddin, S A AU - Butt, T AU - Yasmeen, A AU - Li, A. AU - Zhang, Y AU - Riazuddin, S AU - Hejtmancik, J F Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Mutation KW - Cataracts KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40639044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Mutations+in+bB3-Crystallin%2C+Galk1%2C+Hsf4+are+Associated+with+Autosomal+Recessive+Cataract+in+Pakistani+Families&rft.au=Jiao%2C+X%3BYao%2C+W%3BRiazuddin%2C+S+A%3BButt%2C+T%3BYasmeen%2C+A%3BLi%2C+A.%3BZhang%2C+Y%3BRiazuddin%2C+S%3BHejtmancik%2C+J+F&rft.aulast=Jiao&rft.aufirst=X&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Expression of Protocadherin 15 Isoforms in Mouse Retina by Light and Electron Microscopy T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40638925; 4572348 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Takada, Y AU - Fariss, R N AU - Sieving, P A AU - Bush, R A Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Electron microscopy KW - Retina KW - Protocadherin KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40638925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Differential+Expression+of+Protocadherin+15+Isoforms+in+Mouse+Retina+by+Light+and+Electron+Microscopy&rft.au=Takada%2C+Y%3BFariss%2C+R+N%3BSieving%2C+P+A%3BBush%2C+R+A&rft.aulast=Takada&rft.aufirst=Y&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Analysis of IgH Gene Rearrangements in 61 Patients with Primary Intraocular Lymphoma T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40638853; 4569875 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Gonzales, J A AU - Shen, D AU - Levy-Clarke, G AU - Buggage, R R AU - Mochizuki, M AU - Callanan, D G AU - Nussenblatt, R B AU - Chan, C.-C. Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Lymphoma KW - Immunoglobulins KW - Gene rearrangement KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40638853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Molecular+Analysis+of+IgH+Gene+Rearrangements+in+61+Patients+with+Primary+Intraocular+Lymphoma&rft.au=Gonzales%2C+J+A%3BShen%2C+D%3BLevy-Clarke%2C+G%3BBuggage%2C+R+R%3BMochizuki%2C+M%3BCallanan%2C+D+G%3BNussenblatt%2C+R+B%3BChan%2C+C.-C.&rft.aulast=Gonzales&rft.aufirst=J&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Long Term Retinal Rescue in Retinoschisis Mouse Model by AAV-Gene Transfer T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40638206; 4572480 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Kjellstrom, S AU - Zeng, Y AU - Takada, Y AU - Bush, R AU - Sieving, P Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Retinoschisis KW - Retina KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40638206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Long+Term+Retinal+Rescue+in+Retinoschisis+Mouse+Model+by+AAV-Gene+Transfer&rft.au=Kjellstrom%2C+S%3BZeng%2C+Y%3BTakada%2C+Y%3BBush%2C+R%3BSieving%2C+P&rft.aulast=Kjellstrom&rft.aufirst=S&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single Marker Associations of NFkB Pathway Genes with Advanced AMD T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40637828; 4570317 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Ajudua, S N AU - Elashoff, M AU - Chew, E Y AU - Vora, A AU - Reed, G F AU - Agron, E AU - Henning, A K AU - Clemons, T E AU - Hoh, J AU - SanGiovanni, J P Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - NF-B protein KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40637828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Single+Marker+Associations+of+NFkB+Pathway+Genes+with+Advanced+AMD&rft.au=Ajudua%2C+S+N%3BElashoff%2C+M%3BChew%2C+E+Y%3BVora%2C+A%3BReed%2C+G+F%3BAgron%2C+E%3BHenning%2C+A+K%3BClemons%2C+T+E%3BHoh%2C+J%3BSanGiovanni%2C+J+P&rft.aulast=Ajudua&rft.aufirst=S&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Altered Erp29 and Htra1 Expression in Cultured Retinal Pigment Epithelial (RPE) Cells of Ccl2/Cx3cr1 Deficient Mice - A Model of Age-Related Macular Degeneration T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40637558; 4570681 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Verma, V AU - Shen, D AU - Zhang, C AU - Zhou, M AU - Maminishkis, A AU - Chan, C.-C. AU - Tuo, J Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Pigments KW - Mice KW - CX3CR1 protein KW - Monocyte chemoattractant protein 1 KW - Macular degeneration KW - Retina KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40637558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Altered+Erp29+and+Htra1+Expression+in+Cultured+Retinal+Pigment+Epithelial+%28RPE%29+Cells+of+Ccl2%2FCx3cr1+Deficient+Mice+-+A+Model+of+Age-Related+Macular+Degeneration&rft.au=Verma%2C+V%3BShen%2C+D%3BZhang%2C+C%3BZhou%2C+M%3BMaminishkis%2C+A%3BChan%2C+C.-C.%3BTuo%2C+J&rft.aulast=Verma&rft.aufirst=V&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ocular Complications in Vogt-Koyanagi-Harada Disease T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40637537; 4572948 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Potapova, N V AU - Yeh, S AU - Smith, J A AU - Jirawuthiworavong, G AU - Mahdi, N AU - Chan, C.-C. AU - Nussenblatt, R B AU - Levy-Clarke, G A Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Uveitis KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40637537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Ocular+Complications+in+Vogt-Koyanagi-Harada+Disease&rft.au=Potapova%2C+N+V%3BYeh%2C+S%3BSmith%2C+J+A%3BJirawuthiworavong%2C+G%3BMahdi%2C+N%3BChan%2C+C.-C.%3BNussenblatt%2C+R+B%3BLevy-Clarke%2C+G+A&rft.aulast=Potapova&rft.aufirst=N&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synaptically Released Glycine Influences NMDA Receptor Activation on Retinal Ganglion Cells T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40637512; 4572460 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Kalbaugh, T L AU - Diamond, J S Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Retinal ganglion cells KW - Glycine KW - Glutamic acid receptors KW - Receptor mechanisms KW - N-Methyl-D-aspartic acid receptors KW - Ganglia KW - Retina KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40637512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Synaptically+Released+Glycine+Influences+NMDA+Receptor+Activation+on+Retinal+Ganglion+Cells&rft.au=Kalbaugh%2C+T+L%3BDiamond%2C+J+S&rft.aulast=Kalbaugh&rft.aufirst=T&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Upregulation of Human HTRA1 in Archived Eyes with Age-related Macular Degeneration (AMD) T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40637025; 4571116 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Chan, C.-C. AU - Shen, D AU - Zhou, M AU - Ross, R J AU - Zhang, K AU - Tuo, J Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Macular degeneration KW - Archives KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40637025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Upregulation+of+Human+HTRA1+in+Archived+Eyes+with+Age-related+Macular+Degeneration+%28AMD%29&rft.au=Chan%2C+C.-C.%3BShen%2C+D%3BZhou%2C+M%3BRoss%2C+R+J%3BZhang%2C+K%3BTuo%2C+J&rft.aulast=Chan&rft.aufirst=C.-C.&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Systemic Nsaids and Age-Related Macular Degeneration: The Age-Related Eye Disease Study (AREDS) T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40636324; 4570395 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Sen, H AU - Chew, E Y AU - Agron, E AU - Reed, G F AU - SanGiovanni, J AU - Ferris III, F.L. Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Eye diseases KW - Macular degeneration KW - Nonsteroidal antiinflammatory drugs KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40636324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Systemic+Nsaids+and+Age-Related+Macular+Degeneration%3A+The+Age-Related+Eye+Disease+Study+%28AREDS%29&rft.au=Sen%2C+H%3BChew%2C+E+Y%3BAgron%2C+E%3BReed%2C+G+F%3BSanGiovanni%2C+J%3BFerris+III%2C+F.L.&rft.aulast=Sen&rft.aufirst=H&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Localization and Function of Junctional Adhesion Molecule (JAM)-C in the Retinal Pigment Epithelium (RPE) T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40636179; 4568297 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Economopoulou, M AU - Chavakis, T AU - Miller, S Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Pigments KW - Adhesion KW - Retinal pigment epithelium KW - Retina KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40636179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Localization+and+Function+of+Junctional+Adhesion+Molecule+%28JAM%29-C+in+the+Retinal+Pigment+Epithelium+%28RPE%29&rft.au=Economopoulou%2C+M%3BChavakis%2C+T%3BMiller%2C+S&rft.aulast=Economopoulou&rft.aufirst=M&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Single Marker Associations of Cell Cycle Pathway Genes with Advanced AMD T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40636165; 4570316 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Vora, A AU - SanGiovanni, J P AU - Chew, E Y AU - Ajudua, S N AU - Reed, G F AU - Agron, E AU - Henning, A K AU - Clemons, T E AU - Hoh, J AU - Elashoff, M Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Cell cycle KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40636165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Single+Marker+Associations+of+Cell+Cycle+Pathway+Genes+with+Advanced+AMD&rft.au=Vora%2C+A%3BSanGiovanni%2C+J+P%3BChew%2C+E+Y%3BAjudua%2C+S+N%3BReed%2C+G+F%3BAgron%2C+E%3BHenning%2C+A+K%3BClemons%2C+T+E%3BHoh%2C+J%3BElashoff%2C+M&rft.aulast=Vora&rft.aufirst=A&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Functional WNT Signaling Pathway in the Trabecular Meshwork that Regulates Intraocular Pressure T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40636059; 4567833 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Clark, A F AU - McNatt, L G AU - Hellberg, P E AU - Millar, J C AU - Rubin, J S AU - Pang, I.-H. AU - Wang, W.-H. Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Signal transduction KW - Wnt protein KW - Pressure KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40636059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=A+Functional+WNT+Signaling+Pathway+in+the+Trabecular+Meshwork+that+Regulates+Intraocular+Pressure&rft.au=Clark%2C+A+F%3BMcNatt%2C+L+G%3BHellberg%2C+P+E%3BMillar%2C+J+C%3BRubin%2C+J+S%3BPang%2C+I.-H.%3BWang%2C+W.-H.&rft.aulast=Clark&rft.aufirst=A&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - GITR Promotes Activation Induced Apoptosis of Human NK Cells T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40635365; 4572984 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Liu, B AU - Li, Z. AU - Mahesh, S P AU - Hwang, F S AU - Pantanelli, S AU - Siu, W O AU - Nussenblatt, R B Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Apoptosis KW - Natural killer cells KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40635365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=GITR+Promotes+Activation+Induced+Apoptosis+of+Human+NK+Cells&rft.au=Liu%2C+B%3BLi%2C+Z.%3BMahesh%2C+S+P%3BHwang%2C+F+S%3BPantanelli%2C+S%3BSiu%2C+W+O%3BNussenblatt%2C+R+B&rft.aulast=Liu&rft.aufirst=B&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polarized TCR-Transgenic Th17 Cells Resemble Th1 Cells in their Capacity to Adoptively Transfer Ocular Inflammation, but Differ in Other Biological Activities T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40635223; 4568018 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Cox, C A AU - Shi, G AU - Yin, H AU - Vistica, B P AU - Wawrousek, E F AU - Chan, C.-C. AU - Gery, I Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - T-cell receptor KW - Lymphocytes T KW - Inflammation KW - Helper cells KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40635223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Polarized+TCR-Transgenic+Th17+Cells+Resemble+Th1+Cells+in+their+Capacity+to+Adoptively+Transfer+Ocular+Inflammation%2C+but+Differ+in+Other+Biological+Activities&rft.au=Cox%2C+C+A%3BShi%2C+G%3BYin%2C+H%3BVistica%2C+B+P%3BWawrousek%2C+E+F%3BChan%2C+C.-C.%3BGery%2C+I&rft.aulast=Cox&rft.aufirst=C&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pertussis Toxin (PTX) is Superior to Other Toll-Like Receptor (TLR) Ligands in Shifting T-helper (Th) Cell Populations Towards Th17 T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40635108; 4568016 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Shi, G AU - Vistica, B P AU - Yu, C.-R. AU - Cox, C A AU - Montalvo, V AU - Wawrousek, E F AU - Egwuagu, C E AU - Gery, I Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Toxins KW - Toll-like receptors KW - Lymphocytes T KW - Pertussis toxin KW - Helper cells KW - Ligands KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40635108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Pertussis+Toxin+%28PTX%29+is+Superior+to+Other+Toll-Like+Receptor+%28TLR%29+Ligands+in+Shifting+T-helper+%28Th%29+Cell+Populations+Towards+Th17&rft.au=Shi%2C+G%3BVistica%2C+B+P%3BYu%2C+C.-R.%3BCox%2C+C+A%3BMontalvo%2C+V%3BWawrousek%2C+E+F%3BEgwuagu%2C+C+E%3BGery%2C+I&rft.aulast=Shi&rft.aufirst=G&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Blue Light Induces A2E Oxidation in Rats Eyes T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40634783; 4568475 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Wielgus, A R AU - Lih, F B AU - Tomer, K B AU - Chignell, C F AU - Roberts, J E Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Oxidation KW - Rats KW - Light effects KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40634783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Blue+Light+Induces+A2E+Oxidation+in+Rats+Eyes&rft.au=Wielgus%2C+A+R%3BLih%2C+F+B%3BTomer%2C+K+B%3BChignell%2C+C+F%3BRoberts%2C+J+E&rft.aulast=Wielgus&rft.aufirst=A&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DAP12 Expressed at High Levels in Retinal Capillaries T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40634748; 4573019 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Montalvo, V AU - Campos, M M AU - Tsai, J.-Y. AU - Fariss, R N AU - McVicar, D AU - Gery, I Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - DAP12 protein KW - Capillaries KW - Retina KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40634748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=DAP12+Expressed+at+High+Levels+in+Retinal+Capillaries&rft.au=Montalvo%2C+V%3BCampos%2C+M+M%3BTsai%2C+J.-Y.%3BFariss%2C+R+N%3BMcVicar%2C+D%3BGery%2C+I&rft.aulast=Montalvo&rft.aufirst=V&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In-vitro Rat Retinal Pigment Epithelium (RPE) Electrophysiology T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40633358; 4568502 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Chen, S AU - Banzon, T AU - Wilson, L AU - Miller, S S Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Pigments KW - Retinal pigment epithelium KW - Electrophysiology KW - Retina KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40633358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=In-vitro+Rat+Retinal+Pigment+Epithelium+%28RPE%29+Electrophysiology&rft.au=Chen%2C+S%3BBanzon%2C+T%3BWilson%2C+L%3BMiller%2C+S+S&rft.aulast=Chen&rft.aufirst=S&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression and Localization of Cytochrome 46A1 in Monkey Retina T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40633217; 4568491 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Lee, J W AU - Mast, N AU - Pascual, I AU - Tserentsoodol, N AU - Javitt, N B AU - Pikuleva, I A AU - Gordiyenko, N AU - Rodriguez, I R Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Cytochromes KW - Retina KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40633217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Expression+and+Localization+of+Cytochrome+46A1+in+Monkey+Retina&rft.au=Lee%2C+J+W%3BMast%2C+N%3BPascual%2C+I%3BTserentsoodol%2C+N%3BJavitt%2C+N+B%3BPikuleva%2C+I+A%3BGordiyenko%2C+N%3BRodriguez%2C+I+R&rft.aulast=Lee&rft.aufirst=J&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Histone H2AX Functions in Hypoxia-Driven Retina Neovascularisation T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40633118; 4570039 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Chavakis, T AU - Celeste, A AU - Orlova, V AU - Nussenzweig, A AU - Economopoulou, M Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Retina KW - Histone H2A KW - Histones KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40633118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Histone+H2AX+Functions+in+Hypoxia-Driven+Retina+Neovascularisation&rft.au=Chavakis%2C+T%3BCeleste%2C+A%3BOrlova%2C+V%3BNussenzweig%2C+A%3BEconomopoulou%2C+M&rft.aulast=Chavakis&rft.aufirst=T&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Aberrant Endoplasmic Reticulum Proteins in Ccl2/Cx3cr1 Deficient Mice with Retinal Degeneration Mimicking Human Age-related Macular Degeneration T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40633008; 4571115 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Tuo, J AU - Kevin, R I AU - Zhou, M AU - Shen, D AU - Ross, R J AU - Bojanowski, C M AU - Fariss, R N AU - Yin, C AU - Zhuang, Z AU - Chan, C.-C. Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Mice KW - CX3CR1 protein KW - Monocyte chemoattractant protein 1 KW - Retinal degeneration KW - Macular degeneration KW - Endoplasmic reticulum KW - Mimicry KW - Retina KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40633008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Aberrant+Endoplasmic+Reticulum+Proteins+in+Ccl2%2FCx3cr1+Deficient+Mice+with+Retinal+Degeneration+Mimicking+Human+Age-related+Macular+Degeneration&rft.au=Tuo%2C+J%3BKevin%2C+R+I%3BZhou%2C+M%3BShen%2C+D%3BRoss%2C+R+J%3BBojanowski%2C+C+M%3BFariss%2C+R+N%3BYin%2C+C%3BZhuang%2C+Z%3BChan%2C+C.-C.&rft.aulast=Tuo&rft.aufirst=J&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ocular Immunological Protein Expression in Chemokine Deficient Mice, Potential Models of Age-Related Macular Degeneration T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40632981; 4567996 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Ross, R J AU - Zhou, M AU - Shen, D AU - Bojanowski, C M AU - Fariss, R AU - Tuo, J AU - Chan, C.-C. Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Mice KW - Macular degeneration KW - Chemokines KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40632981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Ocular+Immunological+Protein+Expression+in+Chemokine+Deficient+Mice%2C+Potential+Models+of+Age-Related+Macular+Degeneration&rft.au=Ross%2C+R+J%3BZhou%2C+M%3BShen%2C+D%3BBojanowski%2C+C+M%3BFariss%2C+R%3BTuo%2C+J%3BChan%2C+C.-C.&rft.aulast=Ross&rft.aufirst=R&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Spectral Composition of Cone-Photoreceptor and On-Bipolar Signals in the Zebrafish Electroretinogram T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40632533; 4569639 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Nelson, R F AU - Singla, N Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Spectral composition KW - Electroretinograms KW - Freshwater fish KW - Danio rerio KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40632533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Spectral+Composition+of+Cone-Photoreceptor+and+On-Bipolar+Signals+in+the+Zebrafish+Electroretinogram&rft.au=Nelson%2C+R+F%3BSingla%2C+N&rft.aulast=Nelson&rft.aufirst=R&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Probing Kir Channel Function in Vivo: Potassium Regulation in the RCS Rat Model of Retinal Degeneration T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40632497; 4567924 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Raz, D AU - Fariss, R N AU - Vijayasarathy, C AU - Campos, M M AU - Bush, R A AU - Sieving, P A Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Channels KW - Potassium KW - Retinal degeneration KW - Potassium channels (inwardly-rectifying) KW - Retina KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40632497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Probing+Kir+Channel+Function+in+Vivo%3A+Potassium+Regulation+in+the+RCS+Rat+Model+of+Retinal+Degeneration&rft.au=Raz%2C+D%3BFariss%2C+R+N%3BVijayasarathy%2C+C%3BCampos%2C+M+M%3BBush%2C+R+A%3BSieving%2C+P+A&rft.aulast=Raz&rft.aufirst=D&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Insulin-Like Growth Factor Binding Proteins (IGFBPs) are Differentially Expressed during Neuronal Differentiation of Human Retinal Pigment Epithelial (RPE) Cells Induced by N-(4-hydroxyphenyl)retinamide T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40632458; 4567920 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Samuel, W AU - Kutty, R K AU - Vijayasarathy, C AU - Duncan, T AU - Wiggert, B Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Pigments KW - Growth factors KW - Differentiation KW - Growth KW - Retina KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40632458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Insulin-Like+Growth+Factor+Binding+Proteins+%28IGFBPs%29+are+Differentially+Expressed+during+Neuronal+Differentiation+of+Human+Retinal+Pigment+Epithelial+%28RPE%29+Cells+Induced+by+N-%284-hydroxyphenyl%29retinamide&rft.au=Samuel%2C+W%3BKutty%2C+R+K%3BVijayasarathy%2C+C%3BDuncan%2C+T%3BWiggert%2C+B&rft.aulast=Samuel&rft.aufirst=W&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Study of Retinal Penetration of Intravitreal Full-length Immunoglobulin G in Rats T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40632421; 4568532 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Kim, H AU - Fariss, R N AU - Thill, M AU - Zhang, C AU - Csaky, K G Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Rats KW - Immunoglobulin G KW - Retina KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40632421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=The+Study+of+Retinal+Penetration+of+Intravitreal+Full-length+Immunoglobulin+G+in+Rats&rft.au=Kim%2C+H%3BFariss%2C+R+N%3BThill%2C+M%3BZhang%2C+C%3BCsaky%2C+K+G&rft.aulast=Kim&rft.aufirst=H&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Il-23 and Il-17 in Pathogenesis of Experimental Ocular Autoimmunity: Requirement for Il-23 May Extand Beyond its Role in Sustaining the Il-17 Effector Response T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40632082; 4567798 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Luger, D AU - Silver, P B AU - Cua, D AU - Iwakura, Y AU - Bowman, E P AU - Chan, C.-C. AU - Caspi, R R Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Interleukin 17 KW - Interleukin 23 KW - Autoimmunity KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40632082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Il-23+and+Il-17+in+Pathogenesis+of+Experimental+Ocular+Autoimmunity%3A+Requirement+for+Il-23+May+Extand+Beyond+its+Role+in+Sustaining+the+Il-17+Effector+Response&rft.au=Luger%2C+D%3BSilver%2C+P+B%3BCua%2C+D%3BIwakura%2C+Y%3BBowman%2C+E+P%3BChan%2C+C.-C.%3BCaspi%2C+R+R&rft.aulast=Luger&rft.aufirst=D&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Thil17 Plays a Role in Uveitis and its Expansion is Inhibited by Il-27 T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40631966; 4567852 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Amadi-Obi, A AU - Yu, C.-R. AU - Mahdi, R AU - Liu, X AU - Clarke, G AU - Nussenblatt, R AU - Gery, I AU - Egwuagu, C Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Uveitis KW - Interleukin 27 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40631966?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Thil17+Plays+a+Role+in+Uveitis+and+its+Expansion+is+Inhibited+by+Il-27&rft.au=Amadi-Obi%2C+A%3BYu%2C+C.-R.%3BMahdi%2C+R%3BLiu%2C+X%3BClarke%2C+G%3BNussenblatt%2C+R%3BGery%2C+I%3BEgwuagu%2C+C&rft.aulast=Amadi-Obi&rft.aufirst=A&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Primary Human Fetal Retinal Pigment Epithelial (hfRPE) Culture Growth Optimization using Substrates Obtained from Choroidal Cells Subcellular Fractions and Cell-Conditioned Media T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40631896; 4571167 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Maminishkis, A AU - Bansal, A AU - Crawford, M AU - Miller, S S Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Pigments KW - Cell culture KW - Fetuses KW - Media (culture) KW - Growth KW - Retina KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40631896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Primary+Human+Fetal+Retinal+Pigment+Epithelial+%28hfRPE%29+Culture+Growth+Optimization+using+Substrates+Obtained+from+Choroidal+Cells+Subcellular+Fractions+and+Cell-Conditioned+Media&rft.au=Maminishkis%2C+A%3BBansal%2C+A%3BCrawford%2C+M%3BMiller%2C+S+S&rft.aulast=Maminishkis&rft.aufirst=A&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Autoimmune Uveitis Elicited with Antigen-Pulsed Dendritic Cells has a Distinct Clinical Signature and is Driven by Unique Effector Mechanisms: Initial Encounter with Autoantigen Defines Disease Phenotype T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40629659; 4568015 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Tang, J AU - Zhu, W AU - Sliver, P B AU - Su, S.-B. AU - Chan, C.-C. AU - Caspi, R R Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Uveitis KW - Dendritic cells KW - Autoantigens KW - Environmental effects KW - Phenotypes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40629659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Autoimmune+Uveitis+Elicited+with+Antigen-Pulsed+Dendritic+Cells+has+a+Distinct+Clinical+Signature+and+is+Driven+by+Unique+Effector+Mechanisms%3A+Initial+Encounter+with+Autoantigen+Defines+Disease+Phenotype&rft.au=Tang%2C+J%3BZhu%2C+W%3BSliver%2C+P+B%3BSu%2C+S.-B.%3BChan%2C+C.-C.%3BCaspi%2C+R+R&rft.aulast=Tang&rft.aufirst=J&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Variants within HTRA1 and LOC387715 Independent of CFH are Associated with an Increased Risk of Age-Related Macular Degeneration in a Caucasian Population T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40629417; 4568155 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Bojanowski, C M AU - Tuo, J AU - Ross, R J AU - Shen, D AU - Chew, E Y AU - Chan, C.-C. Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Macular degeneration KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40629417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Variants+within+HTRA1+and+LOC387715+Independent+of+CFH+are+Associated+with+an+Increased+Risk+of+Age-Related+Macular+Degeneration+in+a+Caucasian+Population&rft.au=Bojanowski%2C+C+M%3BTuo%2C+J%3BRoss%2C+R+J%3BShen%2C+D%3BChew%2C+E+Y%3BChan%2C+C.-C.&rft.aulast=Bojanowski&rft.aufirst=C&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Profiling during Optic Fissure Closure T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40629390; 4568118 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Brown, J D AU - Alur, R P AU - Bonner, R F AU - Munson, P J AU - Loftus, S AU - Lee, T AU - Pang, A AU - Chan, W.-Y. AU - Brooks, B P Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Optics KW - Gene expression KW - Profiling KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40629390?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Gene+Expression+Profiling+during+Optic+Fissure+Closure&rft.au=Brown%2C+J+D%3BAlur%2C+R+P%3BBonner%2C+R+F%3BMunson%2C+P+J%3BLoftus%2C+S%3BLee%2C+T%3BPang%2C+A%3BChan%2C+W.-Y.%3BBrooks%2C+B+P&rft.aulast=Brown&rft.aufirst=J&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ocular Surface Changes after Hematopoietic Stem Cell Transplant (HSCT): The Shifting Clinical Spectrum of Ocular Graft Versus Host Disease (oGVHD) T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40629199; 4568782 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Lew, J C AU - Smith, J A AU - Rubin, B AU - Bishop, R AU - Robinson, M R AU - Pavletic, S Z Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Stem cells KW - Transplants KW - Hosts KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40629199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=Ocular+Surface+Changes+after+Hematopoietic+Stem+Cell+Transplant+%28HSCT%29%3A+The+Shifting+Clinical+Spectrum+of+Ocular+Graft+Versus+Host+Disease+%28oGVHD%29&rft.au=Lew%2C+J+C%3BSmith%2C+J+A%3BRubin%2C+B%3BBishop%2C+R%3BRobinson%2C+M+R%3BPavletic%2C+S+Z&rft.aulast=Lew&rft.aufirst=J&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Sex-Based Comparison of the Disease Manifestations of Sjogrens Syndrome T2 - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AN - 40628448; 4568838 JF - 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO 2007) AU - Smith, J A AU - Kutty, V AU - Reed, G AU - Nashwinter, R AU - Leakan, R AU - Koutsandreas, D AU - Illei, G Y1 - 2007/05/06/ PY - 2007 DA - 2007 May 06 KW - Sjogren's syndrome KW - Symptoms KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40628448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.atitle=A+Sex-Based+Comparison+of+the+Disease+Manifestations+of+Sjogrens+Syndrome&rft.au=Smith%2C+J+A%3BKutty%2C+V%3BReed%2C+G%3BNashwinter%2C+R%3BLeakan%2C+R%3BKoutsandreas%2C+D%3BIllei%2C+G&rft.aulast=Smith&rft.aufirst=J&rft.date=2007-05-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28ARVO+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0AEC998A%2D0BCA%2D41AF% 2DA530%2D43715608C824%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Atypical Patterns of Cortical Activation in Healthy Children and Children with Adhd While Viewing Emotional Facial Expressions T2 - 2007 Annual Meeting of the Cognitive Neuroscience Society (CNS 2007) AN - 39407753; 4597191 JF - 2007 Annual Meeting of the Cognitive Neuroscience Society (CNS 2007) AU - Marsh, Abigail AU - Finger, Elizabeth AU - Mitchell, Derek AU - Pine, Daniel AU - Blair, R.J.R. Y1 - 2007/05/05/ PY - 2007 DA - 2007 May 05 KW - Children KW - Emotions KW - Cortex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39407753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.atitle=Atypical+Patterns+of+Cortical+Activation+in+Healthy+Children+and+Children+with+Adhd+While+Viewing+Emotional+Facial+Expressions&rft.au=Marsh%2C+Abigail%3BFinger%2C+Elizabeth%3BMitchell%2C+Derek%3BPine%2C+Daniel%3BBlair%2C+R.J.R.&rft.aulast=Marsh&rft.aufirst=Abigail&rft.date=2007-05-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cnsmeeting.org/CNS_2007_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Increased Human Hippocampal Theta Activation Related to Goal-Directed Navigation Revealed by Spatially-Filtered Magnetoencephalography (MEG) T2 - 2007 Annual Meeting of the Cognitive Neuroscience Society (CNS 2007) AN - 39379261; 4597613 JF - 2007 Annual Meeting of the Cognitive Neuroscience Society (CNS 2007) AU - Johnson, Linda AU - Cornwell, Brian AU - Holroyd, Tom AU - Grillon, Christian Y1 - 2007/05/05/ PY - 2007 DA - 2007 May 05 KW - Navigation KW - Magnetoencephalography KW - Hippocampus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39379261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.atitle=Increased+Human+Hippocampal+Theta+Activation+Related+to+Goal-Directed+Navigation+Revealed+by+Spatially-Filtered+Magnetoencephalography+%28MEG%29&rft.au=Johnson%2C+Linda%3BCornwell%2C+Brian%3BHolroyd%2C+Tom%3BGrillon%2C+Christian&rft.aulast=Johnson&rft.aufirst=Linda&rft.date=2007-05-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cnsmeeting.org/CNS_2007_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Capturing Neural Processes of Fear Excitation and Inhibition with Event-Related Synthetic Aperture Magnetometry T2 - 2007 Annual Meeting of the Cognitive Neuroscience Society (CNS 2007) AN - 39378794; 4597539 JF - 2007 Annual Meeting of the Cognitive Neuroscience Society (CNS 2007) AU - Cornwell, Brian AU - Johnson, Linda AU - Grillon, Christian Y1 - 2007/05/05/ PY - 2007 DA - 2007 May 05 KW - Fear KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39378794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.atitle=Capturing+Neural+Processes+of+Fear+Excitation+and+Inhibition+with+Event-Related+Synthetic+Aperture+Magnetometry&rft.au=Cornwell%2C+Brian%3BJohnson%2C+Linda%3BGrillon%2C+Christian&rft.aulast=Cornwell&rft.aufirst=Brian&rft.date=2007-05-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cnsmeeting.org/CNS_2007_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neural Correlates of Reward Expectancy during Instrumental Learning T2 - 2007 Annual Meeting of the Cognitive Neuroscience Society (CNS 2007) AN - 39371020; 4597828 JF - 2007 Annual Meeting of the Cognitive Neuroscience Society (CNS 2007) AU - Crowe, Samantha AU - Wu, Charlene AU - Blair, James Y1 - 2007/05/05/ PY - 2007 DA - 2007 May 05 KW - Learning KW - Reinforcement KW - Expectancy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39371020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.atitle=Neural+Correlates+of+Reward+Expectancy+during+Instrumental+Learning&rft.au=Crowe%2C+Samantha%3BWu%2C+Charlene%3BBlair%2C+James&rft.aulast=Crowe&rft.aufirst=Samantha&rft.date=2007-05-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cnsmeeting.org/CNS_2007_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ventromedial Prefrontal Cortex Mediates Imagined Physical Aggression in Male Adolescents T2 - 2007 Annual Meeting of the Cognitive Neuroscience Society (CNS 2007) AN - 39365188; 4597069 JF - 2007 Annual Meeting of the Cognitive Neuroscience Society (CNS 2007) AU - Strenziok, Maren AU - Krueger, Frank AU - Lenroot, Rhoshel AU - van der Meer, Elke AU - Grafman, Jordan Y1 - 2007/05/05/ PY - 2007 DA - 2007 May 05 KW - Adolescents KW - Aggressive behavior KW - Cortex (prefrontal) KW - Aggressive behaviour KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39365188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.atitle=Ventromedial+Prefrontal+Cortex+Mediates+Imagined+Physical+Aggression+in+Male+Adolescents&rft.au=Strenziok%2C+Maren%3BKrueger%2C+Frank%3BLenroot%2C+Rhoshel%3Bvan+der+Meer%2C+Elke%3BGrafman%2C+Jordan&rft.aulast=Strenziok&rft.aufirst=Maren&rft.date=2007-05-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cnsmeeting.org/CNS_2007_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High-Resolution fMRI of the Human Perirhinal Cortex during Paired-Associate Learning T2 - 2007 Annual Meeting of the Cognitive Neuroscience Society (CNS 2007) AN - 39353427; 4597709 JF - 2007 Annual Meeting of the Cognitive Neuroscience Society (CNS 2007) AU - Simmons, W Kyle AU - Matlis, Sean AU - Bellgowan, Patrick S.F. AU - Bodurka, Jerzy AU - Barsalou, Lawrence W AU - Martin, Alex Y1 - 2007/05/05/ PY - 2007 DA - 2007 May 05 KW - Cortex (perirhinal) KW - Learning KW - Functional magnetic resonance imaging KW - Associative learning KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39353427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.atitle=High-Resolution+fMRI+of+the+Human+Perirhinal+Cortex+during+Paired-Associate+Learning&rft.au=Simmons%2C+W+Kyle%3BMatlis%2C+Sean%3BBellgowan%2C+Patrick+S.F.%3BBodurka%2C+Jerzy%3BBarsalou%2C+Lawrence+W%3BMartin%2C+Alex&rft.aulast=Simmons&rft.aufirst=W&rft.date=2007-05-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cnsmeeting.org/CNS_2007_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Top-Down Attentional Control under the Influence of Distracter Emotionality and Visibility: An Event-Related fMRI Study T2 - 2007 Annual Meeting of the Cognitive Neuroscience Society (CNS 2007) AN - 39348342; 4597192 JF - 2007 Annual Meeting of the Cognitive Neuroscience Society (CNS 2007) AU - Luo, Qian AU - Mitchell, Derek AU - Vythilingam, Meena AU - Mondillo, Krystal AU - Kamel, Niveen AU - Blair, James Y1 - 2007/05/05/ PY - 2007 DA - 2007 May 05 KW - Visibility KW - Attention KW - Functional magnetic resonance imaging KW - Emotions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39348342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.atitle=Top-Down+Attentional+Control+under+the+Influence+of+Distracter+Emotionality+and+Visibility%3A+An+Event-Related+fMRI+Study&rft.au=Luo%2C+Qian%3BMitchell%2C+Derek%3BVythilingam%2C+Meena%3BMondillo%2C+Krystal%3BKamel%2C+Niveen%3BBlair%2C+James&rft.aulast=Luo&rft.aufirst=Qian&rft.date=2007-05-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cnsmeeting.org/CNS_2007_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamic Correlations of Prefrontal Cortex Neurons Representing Future and Previous Goals T2 - 2007 Annual Meeting of the Cognitive Neuroscience Society (CNS 2007) AN - 39341073; 4596969 JF - 2007 Annual Meeting of the Cognitive Neuroscience Society (CNS 2007) AU - Tsujimoto, Satoshi AU - Genovesio, Aldo AU - Wise, Steven Y1 - 2007/05/05/ PY - 2007 DA - 2007 May 05 KW - Neurons KW - Cortex (prefrontal) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39341073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.atitle=Dynamic+Correlations+of+Prefrontal+Cortex+Neurons+Representing+Future+and+Previous+Goals&rft.au=Tsujimoto%2C+Satoshi%3BGenovesio%2C+Aldo%3BWise%2C+Steven&rft.aulast=Tsujimoto&rft.aufirst=Satoshi&rft.date=2007-05-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cnsmeeting.org/CNS_2007_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Choosing the Lesser of Two Evils, the Better of Two Goods: The Role of 5-Httlpr Genotype and Tryptophan Depletion State in Object Choice T2 - 2007 Annual Meeting of the Cognitive Neuroscience Society (CNS 2007) AN - 39340236; 4597200 JF - 2007 Annual Meeting of the Cognitive Neuroscience Society (CNS 2007) AU - Blair, Karina AU - Finger, Elizabeth AU - Marsh, Abigail AU - Morton, John AU - Buzas, Beata AU - Goldman, David AU - Drevets, Wayne AU - Blair, James Y1 - 2007/05/05/ PY - 2007 DA - 2007 May 05 KW - Genotypes KW - Tryptophan KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39340236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.atitle=Choosing+the+Lesser+of+Two+Evils%2C+the+Better+of+Two+Goods%3A+The+Role+of+5-Httlpr+Genotype+and+Tryptophan+Depletion+State+in+Object+Choice&rft.au=Blair%2C+Karina%3BFinger%2C+Elizabeth%3BMarsh%2C+Abigail%3BMorton%2C+John%3BBuzas%2C+Beata%3BGoldman%2C+David%3BDrevets%2C+Wayne%3BBlair%2C+James&rft.aulast=Blair&rft.aufirst=Karina&rft.date=2007-05-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cnsmeeting.org/CNS_2007_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Medial Ofc and Amygdala Mediate Appetitive and Aversive Based Operant Extinction Learning in Humans T2 - 2007 Annual Meeting of the Cognitive Neuroscience Society (CNS 2007) AN - 39333644; 4597846 JF - 2007 Annual Meeting of the Cognitive Neuroscience Society (CNS 2007) AU - Finger, Elizabeth AU - Mitchell, Derek AU - Jones, Matthew AU - Blair, James Y1 - 2007/05/05/ PY - 2007 DA - 2007 May 05 KW - Extinction KW - Learning KW - Amygdala KW - Operant conditioning KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39333644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.atitle=Medial+Ofc+and+Amygdala+Mediate+Appetitive+and+Aversive+Based+Operant+Extinction+Learning+in+Humans&rft.au=Finger%2C+Elizabeth%3BMitchell%2C+Derek%3BJones%2C+Matthew%3BBlair%2C+James&rft.aulast=Finger&rft.aufirst=Elizabeth&rft.date=2007-05-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cnsmeeting.org/CNS_2007_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selective Involvement of Posterior Sts in Recognizing Emotion from Motion T2 - 2007 Annual Meeting of the Cognitive Neuroscience Society (CNS 2007) AN - 39332792; 4597566 JF - 2007 Annual Meeting of the Cognitive Neuroscience Society (CNS 2007) AU - Silvers, Jennifer AU - Wheatley, Thalia AU - Martin, Alex Y1 - 2007/05/05/ PY - 2007 DA - 2007 May 05 KW - Emotions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39332792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.atitle=Selective+Involvement+of+Posterior+Sts+in+Recognizing+Emotion+from+Motion&rft.au=Silvers%2C+Jennifer%3BWheatley%2C+Thalia%3BMartin%2C+Alex&rft.aulast=Silvers&rft.aufirst=Jennifer&rft.date=2007-05-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cnsmeeting.org/CNS_2007_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multitasking of Attention and Memory in Prefrontal Cortex. T2 - 2007 Annual Meeting of the Cognitive Neuroscience Society (CNS 2007) AN - 39301799; 4597680 JF - 2007 Annual Meeting of the Cognitive Neuroscience Society (CNS 2007) AU - Messinger, Adam AU - Lebedev, Mikhail AU - Kralik, Jerald AU - Wise, Steven Y1 - 2007/05/05/ PY - 2007 DA - 2007 May 05 KW - Cortex (prefrontal) KW - Memory KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39301799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.atitle=Multitasking+of+Attention+and+Memory+in+Prefrontal+Cortex.&rft.au=Messinger%2C+Adam%3BLebedev%2C+Mikhail%3BKralik%2C+Jerald%3BWise%2C+Steven&rft.aulast=Messinger&rft.aufirst=Adam&rft.date=2007-05-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Cognitive+Neuroscience+Society+%28CNS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.cnsmeeting.org/CNS_2007_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - The membrane integration of a naturally occurring alpha-helical hairpin. AN - 70311232; 17367760 AB - Helical hairpins, two closely spaced helical membrane spanning segments separated by a short surface turn, are thought to be common in integral membrane proteins. Here, we study the membrane integration of a naturally occurring helical hairpin from the secretory Na(+)-K(+)-2Cl(-) cotransporter NKCC1. This sequence is only slightly longer and significantly less hydrophobic than a previously identified minimal poly-leucine model hairpin structure. Using site directed mutagenesis we document the importance of the turn propensity of the amino acids in the intervening surface turn but, somewhat surprisingly, our results indicate that the formation of this natural hairpin apparently does not depend on specific helix-helix interactions. Our results suggest that helical hairpins may be formed quite readily from even minimally hydrophobic sequences separated by a short, sufficiently strong, turn signal, and that current methods for predicting integral membrane protein topology may miss many similar short helical hairpin sequences. Thus the occurrence of these structures may be much more common than presently thought. JF - Biochemical and biophysical research communications AU - Nagy, Akos AU - Turner, R James AD - Membrane Biology Section, Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD 20892, USA. Y1 - 2007/05/04/ PY - 2007 DA - 2007 May 04 SP - 392 EP - 397 VL - 356 IS - 2 SN - 0006-291X, 0006-291X KW - Membrane Proteins KW - 0 KW - Peptides KW - SLC12A2 protein, human KW - Sodium-Potassium-Chloride Symporters KW - Solute Carrier Family 12, Member 2 KW - Index Medicus KW - Protein Structure, Secondary KW - Membranes KW - Cells, Cultured KW - Humans KW - Sodium-Potassium-Chloride Symporters -- chemistry KW - Membrane Proteins -- chemistry KW - Protein Folding KW - Peptides -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70311232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=The+membrane+integration+of+a+naturally+occurring+alpha-helical+hairpin.&rft.au=Nagy%2C+Akos%3BTurner%2C+R+James&rft.aulast=Nagy&rft.aufirst=Akos&rft.date=2007-05-04&rft.volume=356&rft.issue=2&rft.spage=392&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-05 N1 - Date created - 2007-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease. AN - 70440004; 17417831 AB - We previously identified structurally diverse small molecule (non-peptidic) inhibitors (SMNPIs) of the botulinum neurotoxin serotype A (BoNT/A) light chain (LC). Of these, several (including antimalarial drugs) contained a 4-amino-7-chloroquinoline (ACQ) substructure and a separate positive ionizable amine component. The same antimalarials have also been found to interfere with BoNT/A translocation into neurons, via pH elevation of the toxin-mediated endosome. Thus, this structural class of small molecules may serve as dual-function BoNT/A inhibitors. In this study, we used a refined pharmacophore for BoNT/A LC inhibition to identify four new, potent inhibitors of this structural class (IC50's ranged from 3.2 to 17 muM). Molecular docking indicated that the binding modes for the new SMNPIs are consistent with those of other inhibitors that we have identified, further supporting our structure-based pharmacophore. Finally, structural motifs of the new SMNPIs, as well as two structure-based derivatives, were examined for activity, providing valuable information about pharmacophore component contributions to inhibition. JF - Journal of medicinal chemistry AU - Burnett, James C AU - Opsenica, Dejan AU - Sriraghavan, Kamaraj AU - Panchal, Rekha G AU - Ruthel, Gordon AU - Hermone, Ann R AU - Nguyen, Tam L AU - Kenny, Tara A AU - Lane, Douglas J AU - McGrath, Connor F AU - Schmidt, James J AU - Vennerstrom, Jonathan L AU - Gussio, Rick AU - Solaja, Bogdan A AU - Bavari, Sina AD - SAIC-Frederick, Inc., Target Structure-Based Drug Discovery Group, Frederick, Frederick, Inc., National Cancer Institute at Frederick, P.O. Box B, F.V.C. 310, Frederick, Maryland 21702, USA. Y1 - 2007/05/03/ PY - 2007 DA - 2007 May 03 SP - 2127 EP - 2136 VL - 50 IS - 9 SN - 0022-2623, 0022-2623 KW - Aminoquinolines KW - 0 KW - Metalloproteases KW - EC 3.4.- KW - Botulinum Toxins, Type A KW - EC 3.4.24.69 KW - Index Medicus KW - Protein Binding KW - Structure-Activity Relationship KW - Binding Sites KW - Aminoquinolines -- chemical synthesis KW - Metalloproteases -- chemistry KW - Aminoquinolines -- chemistry KW - Metalloproteases -- antagonists & inhibitors KW - Models, Molecular KW - Botulinum Toxins, Type A -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70440004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=A+refined+pharmacophore+identifies+potent+4-amino-7-chloroquinoline-based+inhibitors+of+the+botulinum+neurotoxin+serotype+A+metalloprotease.&rft.au=Burnett%2C+James+C%3BOpsenica%2C+Dejan%3BSriraghavan%2C+Kamaraj%3BPanchal%2C+Rekha+G%3BRuthel%2C+Gordon%3BHermone%2C+Ann+R%3BNguyen%2C+Tam+L%3BKenny%2C+Tara+A%3BLane%2C+Douglas+J%3BMcGrath%2C+Connor+F%3BSchmidt%2C+James+J%3BVennerstrom%2C+Jonathan+L%3BGussio%2C+Rick%3BSolaja%2C+Bogdan+A%3BBavari%2C+Sina&rft.aulast=Burnett&rft.aufirst=James&rft.date=2007-05-03&rft.volume=50&rft.issue=9&rft.spage=2127&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=00222623&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-26 N1 - Date created - 2007-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Press Release: Unstable Leukemia Stem Cells May Predispose Patients to Drug Resistance AN - 21292098; 7419434 JF - Journal of the National Cancer Institute AU - Savage, Liz AD - 301-841-1287 , Journal of the National Cancer Institute, jncimedia@oxfordjournals.org Y1 - 2007/05/02/ PY - 2007 DA - 2007 May 02 SP - 657 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 9 SN - 0027-8874, 0027-8874 KW - Biotechnology and Bioengineering Abstracts KW - Leukemia KW - Stem cells KW - Drug resistance KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21292098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Press+Release%3A+Unstable+Leukemia+Stem+Cells+May+Predispose+Patients+to+Drug+Resistance&rft.au=Savage%2C+Liz&rft.aulast=Savage&rft.aufirst=Liz&rft.date=2007-05-02&rft.volume=99&rft.issue=9&rft.spage=657&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Leukemia; Stem cells; Drug resistance ER - TY - JOUR T1 - Early attention and literacy experiences predict adaptive communication AN - 85658220; 200803119 AB - The present study investigated the contributions of sociodemographic factors, literacy experiences and child attention in predicting 2- to 5-year-olds' adaptive communication. In infancy, children participated in a habituation procedure, and length of their first look at a novel stimulus was used as an index of information processing. When children were 2-5 years of age, information about children's literacy experiences was gathered, and communication was assessed using the Communication Domain of the Vineland Adaptive Behavior Scales. Path analyses revealed direct effects for first look, reading per week and number of trips to the library for Adaptive Communication and the subdomain of Expressive Communication. Indirect effects of mother's education through first look, reading per week and child educational experiences also emerged. Path analyses revealed direct effects for amount of reading per week and number of trips to the library for the subdomain of Receptive Communication. [Reprinted by permission of Sage Publications, Ltd., copyright 2007.] JF - First Language AU - Arterberry, Martha E AU - Midgett, Corina AU - Putnick, Diane L AU - Bornstein, Marc H AD - National Institutes of Health, Rockledge 1, Suite 8030, 6705 Rockledge Drive, MSC 7971, Bethesda MD 20892-7971, USA Martha.Arterberry@colby.edu Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 175 EP - 189 VL - 27 IS - 2 SN - 0142-7237, 0142-7237 KW - Joint Reading (39770) KW - Child Language (11800) KW - Educational Level (20920) KW - Literacy (48550) KW - Eye Movements (23600) KW - Parents (62770) KW - Attention (05350) KW - Learning Environment (45880) KW - Communicative Competence (13650) KW - article KW - 4015: psycholinguistics; child language acquisition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85658220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=First+Language&rft.atitle=Early+attention+and+literacy+experiences+predict+adaptive+communication&rft.au=Arterberry%2C+Martha+E%3BMidgett%2C+Corina%3BPutnick%2C+Diane+L%3BBornstein%2C+Marc+H&rft.aulast=Arterberry&rft.aufirst=Martha&rft.date=2007-05-01&rft.volume=27&rft.issue=2&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=First+Language&rft.issn=01427237&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2008-03-01 N1 - Last updated - 2016-09-27 N1 - CODEN - FILAE2 N1 - SubjectsTermNotLitGenreText - Child Language (11800); Communicative Competence (13650); Learning Environment (45880); Literacy (48550); Attention (05350); Eye Movements (23600); Joint Reading (39770); Parents (62770); Educational Level (20920) ER - TY - JOUR T1 - They have shaped Alzheimer disease: the protagonists, well known and less well known. AN - 85412458; pmid-17624003 AB - This paper discusses the history of dementia and Alzheimer's disease (AD) with emphasis on the individuals who have shaped its development. In addition to the best known protagonists recognized as founders of the field, it will mention other figures who have provided important contributions but are sometimes overlooked. Many of these have also become famous for work unrelated to AD. JF - Cortex; a journal devoted to the study of the nervous system and behavior AU - Boller, François AU - Bick, Katherine AU - Duyckaerts, Charles AD - INSERM U 549, Centre Paul Broca, Paris, France. bollerf@csr.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 565 EP - 569 VL - 43 IS - 4 SN - 0010-9452, 0010-9452 KW - Index Medicus KW - National Library of Medicine KW - *Alzheimer Disease: history KW - Europe KW - History, 18th Century KW - History, 19th Century KW - History, 20th Century KW - History, Ancient KW - Humans KW - United States UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85412458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cortex%3B+a+journal+devoted+to+the+study+of+the+nervous+system+and+behavior&rft.atitle=They+have+shaped+Alzheimer+disease%3A+the+protagonists%2C+well+known+and+less+well+known.&rft.au=Boller%2C+Fran%C3%A7ois%3BBick%2C+Katherine%3BDuyckaerts%2C+Charles&rft.aulast=Boller&rft.aufirst=Fran%C3%A7ois&rft.date=2007-05-01&rft.volume=43&rft.issue=4&rft.spage=565&rft.isbn=&rft.btitle=&rft.title=Cortex%3B+a+journal+devoted+to+the+study+of+the+nervous+system+and+behavior&rft.issn=00109452&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Maternal personality and parenting cognitions in cross-cultural perspective AN - 742724347; 201015198 AB - A total of 467 mothers of firstborn 20-month-old children from 7 countries (103 Argentine, 61 Belgian, 39 Israeli, 78 Italian, 57 Japanese, 69 Korean, and 60 US American) completed the Jackson Personality Inventory (JPI), measures of parenting cognitions (self-perceptions and knowledge), and a social desirability scale. Our first analysis showed that the Five-Factor structure of personality (Openness, Neuroticism, Extraversion, Agreeableness, and Conscientiousness) could be extracted from the JPI scales when cross-cultural data from mothers in the 7 countries were analyzed; it was also replicable and generalizable in mothers from so-called individualist and collectivist cultures. Our second analysis showed that the five personality factors relate differently to diverse parenting cognitions in those individualist versus collectivist cultures. Maternal personality has significance in studies of normative parenting, child development, and family process across cultural contexts. Adapted from the source document. JF - International Journal of Behavioral Development AU - Bornstein, Marc H AU - Hahn, Chun-Shin AU - Haynes, O Maurice AU - Belsky, J AU - Azuma, Hiroshi AU - Kwak, Keumjoo AU - Maital, Sharone AU - Painter, Kathleen M AU - Varron, Cheryl AU - Pascual, Liliana AU - Toda, Sueko AU - Venuti, Paola AU - Vyt, Andre AU - de Galperin, Celia Zingman AD - National Institute of Child Health and Human Development Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 193 EP - 209 PB - Sage Publications, Thousand Oaks, CA VL - 31 IS - 3 SN - 0165-0254, 0165-0254 KW - collectivism individualism parenting parenting cognitions personality KW - Maternal characteristics KW - Parenting KW - Individualism KW - Mothers KW - Personality KW - Cognition KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/742724347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Behavioral+Development&rft.atitle=Maternal+personality+and+parenting+cognitions+in+cross-cultural+perspective&rft.au=Bornstein%2C+Marc+H%3BHahn%2C+Chun-Shin%3BHaynes%2C+O+Maurice%3BBelsky%2C+J%3BAzuma%2C+Hiroshi%3BKwak%2C+Keumjoo%3BMaital%2C+Sharone%3BPainter%2C+Kathleen+M%3BVarron%2C+Cheryl%3BPascual%2C+Liliana%3BToda%2C+Sueko%3BVenuti%2C+Paola%3BVyt%2C+Andre%3Bde+Galperin%2C+Celia+Zingman&rft.aulast=Bornstein&rft.aufirst=Marc&rft.date=2007-05-01&rft.volume=31&rft.issue=3&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Behavioral+Development&rft.issn=01650254&rft_id=info:doi/10.1177%2F0165025407074632 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2010-07-12 N1 - Last updated - 2016-09-27 N1 - CODEN - IJBDDY N1 - SubjectsTermNotLitGenreText - Parenting; Cognition; Personality; Mothers; Individualism; Maternal characteristics DO - http://dx.doi.org/10.1177/0165025407074632 ER - TY - JOUR T1 - Preventing needlestick injuries. AN - 70761406; 17658957 AB - Inadvertent puncture during use, disassembly, or disposal of needles or sharp devices (called collectively, "sharps") creates risk beyond a simple puncture. Sharps injury has always been a risk for health care workers, but emergence of certain blood-borne pathogens has intensified the need to act. Three- hepatitis B, hepatitis C, and HIV-are of utmost concern because they can cause significant morbidity or death. The incidence of sharps injury remains unacceptably high. Injury analysis at long-term care facilities and at the national level reveals several trends that can be used to shape policy and select interventions. Policy, practice, and training need to address new devices engineered to prevent sharps injuries, sharps disposal containers, and prophylaxis after percutaneous injury. JF - The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists AU - Zanni, Guido R AU - Wick, Jeannette Y AD - National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 400 EP - 2, 404-6, 409 VL - 22 IS - 5 SN - 0888-5109, 0888-5109 KW - Medical Waste Disposal KW - 0 KW - Index Medicus KW - United States KW - Hepatitis C -- prevention & control KW - HIV Infections -- transmission KW - Hepatitis C -- transmission KW - Humans KW - Pharmacists KW - Hepatitis B -- transmission KW - United States Occupational Safety and Health Administration -- legislation & jurisprudence KW - Equipment Design KW - Hepatitis B -- prevention & control KW - Professional Role KW - HIV Infections -- prevention & control KW - Incidence KW - Infectious Disease Transmission, Patient-to-Professional -- prevention & control KW - Protective Devices KW - Needles KW - Accidents, Occupational -- prevention & control KW - Needlestick Injuries -- prevention & control KW - Health Personnel KW - Safety Management KW - Needlestick Injuries -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70761406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Consultant+pharmacist+%3A+the+journal+of+the+American+Society+of+Consultant+Pharmacists&rft.atitle=Preventing+needlestick+injuries.&rft.au=Zanni%2C+Guido+R%3BWick%2C+Jeannette+Y&rft.aulast=Zanni&rft.aufirst=Guido&rft.date=2007-05-01&rft.volume=22&rft.issue=5&rft.spage=400&rft.isbn=&rft.btitle=&rft.title=The+Consultant+pharmacist+%3A+the+journal+of+the+American+Society+of+Consultant+Pharmacists&rft.issn=08885109&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-27 N1 - Date created - 2007-07-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Aplasia cutis congenita following in utero methimazole exposure. AN - 70748114; 17642418 JF - Journal of pediatric endocrinology & metabolism : JPEM AU - Baid, Smita K AU - Merke, Deborah P AD - Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. baids@mail.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 585 EP - 586 VL - 20 IS - 5 SN - 0334-018X, 0334-018X KW - Antithyroid Agents KW - 0 KW - Methimazole KW - 554Z48XN5E KW - Index Medicus KW - Antithyroid Agents -- adverse effects KW - Humans KW - Graves Disease -- drug therapy KW - Female KW - Pregnancy KW - Child, Preschool KW - Abnormalities, Drug-Induced -- diagnosis KW - Methimazole -- adverse effects KW - Ectodermal Dysplasia -- chemically induced KW - Methimazole -- administration & dosage KW - Ectodermal Dysplasia -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70748114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pediatric+endocrinology+%26+metabolism+%3A+JPEM&rft.atitle=Aplasia+cutis+congenita+following+in+utero+methimazole+exposure.&rft.au=Baid%2C+Smita+K%3BMerke%2C+Deborah+P&rft.aulast=Baid&rft.aufirst=Smita&rft.date=2007-05-01&rft.volume=20&rft.issue=5&rft.spage=585&rft.isbn=&rft.btitle=&rft.title=Journal+of+pediatric+endocrinology+%26+metabolism+%3A+JPEM&rft.issn=0334018X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-22 N1 - Date created - 2007-07-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chronic bronchitis among nonsmoking farm women in the agricultural health study. AN - 70495545; 17495700 AB - The purpose of this study was to examine agricultural risk factors for chronic bronchitis among nonsmoking farm women. We used self-reported enrollment data from the 21,541 nonsmoking women in the Agricultural Health Study to evaluate occupational risk factors for prevalent chronic bronchitis among farm women. Odds ratios (ORs) for chronic bronchitis for occupational exposures were adjusted for age, state, and related agricultural exposures. Applying manure and driving combines were independently associated with chronic bronchitis. Off-farm job exposures associated with chronic bronchitis were organic dusts, asbestos, gasoline, and solvents. Five pesticides were associated with chronic bronchitis after multivariate adjustment and sensitivity analyses: dichlorvos (OR=1.63, 95% CI=1.01, 2.61), DDT (OR=1.67, 95% CI=1.13, 2.47), cyanazine (OR=1.88, 95% CI=1.00, 3.54), paraquat (OR=1.91, 95% CI=1.02, 3.55), and methyl bromide (OR=1.82, 95% CI=1.02, 3.24). Pesticides as well as grain and dust exposures were associated with chronic bronchitis among nonsmoking farm women. JF - Journal of occupational and environmental medicine AU - Valcin, Martin AU - Henneberger, Paul K AU - Kullman, Greg J AU - Umbach, David M AU - London, Stephanie J AU - Alavanja, Michael C R AU - Sandler, Dale P AU - Hoppin, Jane A AD - Epidemiology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709-2233, USA. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 574 EP - 583 VL - 49 IS - 5 SN - 1076-2752, 1076-2752 KW - Pesticides KW - 0 KW - Index Medicus KW - Occupational Exposure KW - Odds Ratio KW - Prospective Studies KW - Humans KW - North Carolina KW - Adult KW - Surveys and Questionnaires KW - Confidence Intervals KW - Aged KW - Middle Aged KW - Iowa KW - Pesticides -- adverse effects KW - Female KW - Agriculture KW - Bronchitis, Chronic -- epidemiology KW - Bronchitis, Chronic -- etiology KW - Bronchitis, Chronic -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70495545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+medicine&rft.atitle=Chronic+bronchitis+among+nonsmoking+farm+women+in+the+agricultural+health+study.&rft.au=Valcin%2C+Martin%3BHenneberger%2C+Paul+K%3BKullman%2C+Greg+J%3BUmbach%2C+David+M%3BLondon%2C+Stephanie+J%3BAlavanja%2C+Michael+C+R%3BSandler%2C+Dale+P%3BHoppin%2C+Jane+A&rft.aulast=Valcin&rft.aufirst=Martin&rft.date=2007-05-01&rft.volume=49&rft.issue=5&rft.spage=574&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+medicine&rft.issn=10762752&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-11 N1 - Date created - 2007-05-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Epidemiology. 2002 Jan;13(1):94-9 [11805592] Am J Respir Crit Care Med. 2002 Mar 1;165(5):683-9 [11874814] J Expo Anal Environ Epidemiol. 2002 Sep;12(5):313-8 [12198579] Chest. 2002 Oct;122(4):1234-9 [12377847] Ann Agric Environ Med. 2002;9(2):119-36 [12498578] Eur Respir J. 2003 Feb;21(2):323-31 [12608449] Occup Environ Med. 2003 Nov;60(11):858-63 [14573716] Occup Environ Med. 2004 Aug;61(8):661-7 [15258271] Am J Ind Med. 2001 Mar;39(3):292-300 [11241562] Respiration. 2001;68(1):4-19 [11223724] Environ Health Perspect. 2000 Aug;108 Suppl 4:705-12 [10931789] Eur Respir J. 2001 Jul;18(1):85-92 [11510810] Am J Respir Crit Care Med. 2001 Jun;163(7):1572-7 [11401876] Am J Ind Med. 2001 Apr;39(4):410-8 [11323791] J Occup Environ Med. 2004 Aug;46(8):856-65 [15300138] Am Rev Respir Dis. 1980 Jan;121(1):11-6 [7352694] Eur J Respir Dis Suppl. 1982;118:35-41 [6954097] Am J Ind Med. 1986;10(3):205-20 [3532776] Am J Ind Med. 1986;10(3):221-7 [3766549] Eur J Respir Dis Suppl. 1987;152:206-11 [3499343] Eur J Respir Dis Suppl. 1987;152:57-63 [3499347] Int J Epidemiol. 1991 Jun;20(2):416-23 [1917244] Am Rev Respir Dis. 1992 Oct;146(4):884-7 [1416414] Occup Med (Lond). 1996 Feb;46(1):89-90 [8672804] Environ Health Perspect. 1996 Apr;104(4):362-9 [8732939] Scand J Work Environ Health. 1997 Aug;23(4):271-80 [9322818] Am J Respir Crit Care Med. 1998 Jun;157(6 Pt 1):1864-70 [9620919] Am J Respir Crit Care Med. 1998 Nov;158(5 Pt 2):S1-S76 [9817727] Occup Environ Med. 2005 Sep;62(9):598-606 [16109815] Respir Med. 2005 Oct;99(10):1319-24 [16102957] Am J Epidemiol. 2006 Jun 15;163(12):1129-37 [16611668] Am J Epidemiol. 2006 Jun 15;163(12):1118-28 [16707657] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mutation rate of the hepatitis C virus NS5B in patients undergoing treatment with ribavirin monotherapy. AN - 70476916; 17484873 AB - Error catastrophe from an increase in mutation rate may be a possible mechanism of action of ribavirin in chronic hepatitis C (CHC). We sought to evaluate the mutagenic potential of ribavirin in vivo and to determine if conserved regions of hepatitis C virus (HCV) NS5B are mutated during ribavirin therapy. Thirty-one patients with CHC genotype 1 who participated in a randomized, placebo-controlled trial of ribavirin for 48 weeks were studied. After 48 weeks, patients on placebo were crossed-over to open-label ribavirin for 48 weeks. Viral RNA was extracted from paired, stored sera at day 0 and week 24 during the randomized phase and weeks 48, 52, and 72 during the cross-over phase. The entire NS5B region was sequenced and the mutation rates were calculated. An increase in mutation rate was observed after 4 weeks (4.4 x 10(-2) vs 2.1 x 10(-3) per site/y, P = .02) but not after 24 weeks (4.0 x 10(-3) vs. 5.5 x 10(-3) per site/y, P = .1) in patients who crossed over to ribavirin. Similarly, during the randomized phase no increase in the number of mutations or the mutation rate was observed at week 24 between the ribavirin- and placebo-treated patients 6.6 vs 4.3 x 10(-3) per site/y, respectively (P = .4). No mutations were observed in conserved regions of NS5B. Ribavirin therapy is associated with an early, transient increase in the mutation rate of HCV. Lethal mutagenesis and error catastrophe is unlikely to be the sole mechanism of action of ribavirin during therapy for CHC. JF - Gastroenterology AU - Lutchman, Glen AU - Danehower, Susan AU - Song, Byung-Cheol AU - Liang, T Jake AU - Hoofnagle, Jay H AU - Thomson, Michael AU - Ghany, Marc G AD - Liver Diseases Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1800, USA. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 1757 EP - 1766 VL - 132 IS - 5 SN - 0016-5085, 0016-5085 KW - Antiviral Agents KW - 0 KW - DNA, Viral KW - NS-5 protein, hepatitis C virus KW - Viral Nonstructural Proteins KW - Viral Proteins KW - Ribavirin KW - 49717AWG6K KW - Abridged Index Medicus KW - Index Medicus KW - Viral Proteins -- genetics KW - Double-Blind Method KW - Dose-Response Relationship, Drug KW - Humans KW - Disease Progression KW - Aged KW - Adult KW - Drug Resistance, Viral -- genetics KW - Cross-Over Studies KW - Middle Aged KW - Time Factors KW - DNA, Viral -- genetics KW - Female KW - Male KW - Antiviral Agents -- therapeutic use KW - Mutagenesis -- drug effects KW - Ribavirin -- therapeutic use KW - Viral Nonstructural Proteins -- genetics KW - Hepacivirus -- genetics KW - Hepatitis C, Chronic -- drug therapy KW - Viral Nonstructural Proteins -- drug effects KW - Hepacivirus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70476916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=Mutation+rate+of+the+hepatitis+C+virus+NS5B+in+patients+undergoing+treatment+with+ribavirin+monotherapy.&rft.au=Lutchman%2C+Glen%3BDanehower%2C+Susan%3BSong%2C+Byung-Cheol%3BLiang%2C+T+Jake%3BHoofnagle%2C+Jay+H%3BThomson%2C+Michael%3BGhany%2C+Marc+G&rft.aulast=Lutchman&rft.aufirst=Glen&rft.date=2007-05-01&rft.volume=132&rft.issue=5&rft.spage=1757&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=00165085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-26 N1 - Date created - 2007-05-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Gastroenterology. 2007 May;132(5):2050-2 [17484896] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relationships among aging, IQ, and intracranial volume in alcoholics and control subjects. AN - 70476077; 17484597 AB - The current article examined the relationships among aging, intelligence, intracranial volume, and brain shrinkage in alcoholics and nonalcoholic controls. Magnetic resonance imaging was used to measure intracranial and cerebral volumes in 146 subjects with alcohol use disorders and 42 comparison subjects who were not alcoholic. The authors' findings show that performance on Block Design decreases as alcoholics age, and this decrease is predicted by brain shrinkage. This is consistent with a process of cumulative brain damage related to alcohol use. However, the authors' data also show that vocabulary does not decrease with age and is correlated with premorbid brain size as measured by intracranial volume, suggesting that lower verbal ability precedes heavy alcohol use and may be a risk factor for alcoholism. (c) 2007 APA, all rights reserved JF - Neuropsychology AU - Schottenbauer, Michele A AU - Momenan, Reza AU - Kerick, Michael AU - Hommer, Daniel W AD - National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 337 EP - 345 VL - 21 IS - 3 SN - 0894-4105, 0894-4105 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Sex Characteristics KW - Substance-Related Disorders -- pathology KW - Humans KW - Vocabulary KW - Aged KW - Substance-Related Disorders -- psychology KW - Psychomotor Performance -- physiology KW - Wechsler Scales KW - Education KW - Psychiatric Status Rating Scales KW - Psychomotor Performance -- drug effects KW - Cognition -- drug effects KW - Adult KW - Cohort Studies KW - Substance-Related Disorders -- complications KW - Middle Aged KW - Female KW - Male KW - Intelligence Tests KW - Alcoholism -- pathology KW - Brain -- pathology KW - Aging -- psychology KW - Brain -- anatomy & histology KW - Alcoholism -- psychology KW - Alcoholism -- complications KW - Intelligence -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70476077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychology&rft.atitle=Relationships+among+aging%2C+IQ%2C+and+intracranial+volume+in+alcoholics+and+control+subjects.&rft.au=Schottenbauer%2C+Michele+A%3BMomenan%2C+Reza%3BKerick%2C+Michael%3BHommer%2C+Daniel+W&rft.aulast=Schottenbauer&rft.aufirst=Michele&rft.date=2007-05-01&rft.volume=21&rft.issue=3&rft.spage=337&rft.isbn=&rft.btitle=&rft.title=Neuropsychology&rft.issn=08944105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-20 N1 - Date created - 2007-05-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of knee injection on skeletal muscle metabolism and contractile force in rats. AN - 70467952; 17157038 AB - We tested the hypothesis that intrusion of the knee joint capsule alters quadriceps muscle metabolism and function independently from the damage induced to knee cartilage. Adult rats were separated into four groups: intraarticular injections of saline (SAL; n=9); intraarticular injections of papain, a model for osteoarthritis (PIA; n=7); sham injections (SHAM; n=8); and controls (CTL; n=5). 31P magnetic resonance spectroscopy (31P-MRS) was performed after 2 weeks. Spectra were obtained from the left quadriceps: two at baseline, eight during electrical stimulation with simultaneous measurement of contractile force, and 15 during recovery. 31P-MRS data were presented as the ratio of inorganic phosphate (Pi) to phosphocreatine (PCr), concentrations of PCr [PCr], intramuscular pH, and the rates and time constants of PCr breakdown during stimulation and PCr recovery. Intramuscular cytokine concentrations were measured within the quadriceps. Histologic slides of the knees were scored for severity of cartilage damage. The interventional groups produced values of Pi/PCr ratio, [PCr], contractile force and pH that were significantly different from CTL. These changes in muscle function were accompanied by higher concentrations of interleukin-1 observed with PIA and SAL. We did not observe any effect of cartilage damage on muscle function or metabolism. Knee joint intrusion alters quadriceps muscle metabolism with accelerated depletion of energy stores and fatigue during stimulation. This study demonstrates that needle intrusion into the knee joint results in muscle dysfunction, independently from the extent of cartilage damage. JF - Osteoarthritis and cartilage AU - Galbán, C J AU - Ling, S M AU - Taub, D D AU - Gurkan, I AU - Fishbein, K W AU - Spencer, R G AD - Drug Delivery and Kinetics Resource, Division of Bioengineering and Physical Science, Office of Research Services, National Institutes of Health, Bethesda, MD 20892-5766, USA. gallbanc@ors.od.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 550 EP - 558 VL - 15 IS - 5 SN - 1063-4584, 1063-4584 KW - Cytokines KW - 0 KW - Phosphocreatine KW - 020IUV4N33 KW - Phosphorus KW - 27YLU75U4W KW - Sodium Chloride KW - 451W47IQ8X KW - Papain KW - EC 3.4.22.2 KW - Index Medicus KW - Models, Animal KW - Animals KW - Osteoarthritis -- chemically induced KW - Papain -- pharmacology KW - Magnetic Resonance Spectroscopy KW - Cytokines -- analysis KW - Rats KW - Injections, Intra-Articular -- adverse effects KW - Cartilage, Articular -- drug effects KW - Phosphocreatine -- analysis KW - Female KW - Sodium Chloride -- pharmacology KW - Quadriceps Muscle -- physiology KW - Muscle Contraction -- physiology KW - Quadriceps Muscle -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70467952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Osteoarthritis+and+cartilage&rft.atitle=Effects+of+knee+injection+on+skeletal+muscle+metabolism+and+contractile+force+in+rats.&rft.au=Galb%C3%A1n%2C+C+J%3BLing%2C+S+M%3BTaub%2C+D+D%3BGurkan%2C+I%3BFishbein%2C+K+W%3BSpencer%2C+R+G&rft.aulast=Galb%C3%A1n&rft.aufirst=C&rft.date=2007-05-01&rft.volume=15&rft.issue=5&rft.spage=550&rft.isbn=&rft.btitle=&rft.title=Osteoarthritis+and+cartilage&rft.issn=10634584&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-27 N1 - Date created - 2007-05-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Causes of death in hyper-IgE syndrome. AN - 70464415; 17335882 AB - Hyper-IgE syndrome (HIES) is characterized by recurrent pyogenic infections, eczema, increased serum IgE levels, and a variety of connective tissue and skeletal system abnormalities. Little has been published regarding the causes of death in these patients or pathologic findings. To identify the cause of death in patients with HIES and to describe pathologic findings in fatal HIES. We reviewed the medical records and autopsy slides of 6 patients with HIES with autopsies performed at our institution. All 6 patients with HIES were women and ranged in age from 24 to 40 years. All patients had a history of cystic lung disease and had pneumonia at the time of death, with Pseudomonas aeruginosa and fungal organisms predominating. Pulmonary fungal vascular invasion with fatal hemorrhage was observed in 3 patients, and metastatic fungal disease to the brain was observed in 2 patients caused by Aspergillus fumigatus and Scedosporium prolificans. Four patients had evidence of renal tubular injury, which was likely from amphotericin B toxicity; 3 patients had glomerulosclerosis; and 1 patient had 2 kidney angiomyolipomas. Our series highlights the important role Pseudomonas and Aspergillus species play in patients with HIES with cystic lung disease. Intensified antifungal and gram-negative bacterial prophylaxis need evaluation as possible strategies to prevent these infectious complications in patients with cystic lung disease. Fungal and Pseudomonas infection of cystic lung disease in HIES may be life threatening, and the proper management and prevention of these infections need continued investigation. JF - The Journal of allergy and clinical immunology AU - Freeman, Alexandra F AU - Kleiner, David E AU - Nadiminti, Hari AU - Davis, Joie AU - Quezado, Martha AU - Anderson, Victoria AU - Puck, Jennifer M AU - Holland, Steven M AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1684, USA. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 1234 EP - 1240 VL - 119 IS - 5 SN - 0091-6749, 0091-6749 KW - Abridged Index Medicus KW - Index Medicus KW - Lung Diseases -- etiology KW - Autopsy KW - Mycoses -- pathology KW - Humans KW - Lung Diseases -- pathology KW - Adult KW - Retrospective Studies KW - Brain Diseases -- pathology KW - Kidney Diseases -- etiology KW - Pseudomonas Infections -- etiology KW - Mycoses -- etiology KW - Brain Diseases -- etiology KW - Female KW - Cause of Death KW - Pneumonia -- microbiology KW - Job Syndrome -- pathology KW - Job Syndrome -- mortality KW - Pneumonia -- pathology KW - Pneumonia -- etiology KW - Job Syndrome -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70464415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=Causes+of+death+in+hyper-IgE+syndrome.&rft.au=Freeman%2C+Alexandra+F%3BKleiner%2C+David+E%3BNadiminti%2C+Hari%3BDavis%2C+Joie%3BQuezado%2C+Martha%3BAnderson%2C+Victoria%3BPuck%2C+Jennifer+M%3BHolland%2C+Steven+M&rft.aulast=Freeman&rft.aufirst=Alexandra&rft.date=2007-05-01&rft.volume=119&rft.issue=5&rft.spage=1234&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=00916749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-06 N1 - Date created - 2007-05-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - MRP2 and acquired tolerance to inorganic arsenic in the kidney of killifish (Fundulus heteroclitus). AN - 70457937; 17324950 AB - We used proximal tubules isolated from the killifish, Fundulus heteroclitus, to examine the effect of environmentally relevant, sublethal levels of arsenic on the function and expression of MRP2, an ABC transporter that transports xenobiotics into urine, including arsenic-glutathione conjugates. Exposure of fish to arsenic as sodium arsenite (4-14 days) increased both MRP2 expression in the apical membrane of proximal tubules and MRP2-mediated transport activity. The level of MRP2 mRNA was not affected, suggesting a posttranslational mechanism of action. Acute exposure of proximal tubules isolated from control fish to 75-375 ppb arsenic decreased mitochondrial function (inner membrane electrical potential). However, in tubules from fish that were preexposed to arsenic (4-14 days), no such effect on mitochondrial function was observed. Thus, chronic in vivo exposure to arsenic induces mechanisms that protect proximal tubules during subsequent arsenic exposure. Upregulation of MRP2 expression and activity is one likely contributing factor. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Miller, David S AU - Shaw, Joseph R AU - Stanton, Caitlin R AU - Barnaby, Roxanna AU - Karlson, Katherine H AU - Hamilton, Joshua W AU - Stanton, Bruce A AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 103 EP - 110 VL - 97 IS - 1 SN - 1096-6080, 1096-6080 KW - Arsenites KW - 0 KW - Fluoresceins KW - Fluorescent Dyes KW - Membrane Transport Proteins KW - Multidrug Resistance-Associated Proteins KW - RNA, Messenger KW - Sodium Compounds KW - Water Pollutants, Chemical KW - fluorescein-methotrexate KW - sodium arsenite KW - 48OVY2OC72 KW - multidrug resistance-associated protein 2 KW - 4AF605U6JN KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Animals KW - Membrane Potential, Mitochondrial -- drug effects KW - Fluorescent Dyes -- metabolism KW - Methotrexate -- analogs & derivatives KW - RNA, Messenger -- metabolism KW - Fluoresceins -- metabolism KW - Dose-Response Relationship, Drug KW - Mitochondria -- drug effects KW - Mitochondria -- metabolism KW - Up-Regulation KW - Tissue Distribution KW - Methotrexate -- metabolism KW - Protein Processing, Post-Translational -- drug effects KW - Sodium Compounds -- metabolism KW - Water Pollutants, Chemical -- toxicity KW - Arsenites -- metabolism KW - Arsenites -- toxicity KW - Drug Tolerance KW - Kidney Tubules, Proximal -- metabolism KW - Multidrug Resistance-Associated Proteins -- genetics KW - Multidrug Resistance-Associated Proteins -- metabolism KW - Sodium Compounds -- toxicity KW - Fundulidae KW - Kidney Tubules, Proximal -- drug effects KW - Membrane Transport Proteins -- genetics KW - Membrane Transport Proteins -- metabolism KW - Water Pollutants, Chemical -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70457937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=MRP2+and+acquired+tolerance+to+inorganic+arsenic+in+the+kidney+of+killifish+%28Fundulus+heteroclitus%29.&rft.au=Miller%2C+David+S%3BShaw%2C+Joseph+R%3BStanton%2C+Caitlin+R%3BBarnaby%2C+Roxanna%3BKarlson%2C+Katherine+H%3BHamilton%2C+Joshua+W%3BStanton%2C+Bruce+A&rft.aulast=Miller&rft.aufirst=David&rft.date=2007-05-01&rft.volume=97&rft.issue=1&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-03 N1 - Date created - 2007-05-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - First-generation blood substitutes: what have we learned? Biochemical and physiological perspectives. AN - 70454037; 17477804 AB - Chemically modified or recombinant hemoglobin (Hb)-based oxygen carriers (HBOCs) have been developed as oxygen therapeutics or 'blood substitutes' for use in a variety of clinical settings. Oxidative and nitrosative reactions of acellular Hb can limit the effectiveness and compromise the safety of HBOCs. The reactions between Hb and biologically relevant redox active molecules may also perturb redox sensitive signaling pathways. In recent years, systematic in vitro and in vivo structural and functional evaluation of several HBOCs has been carried out and, in some cases, delineated the 'structural' origin of their toxicity. This enables potential protective strategies against Hb-mediated side reactions to be rationally suggested. Here the authors provide an overview of their research experiences, novel insights into the molecular basis of toxicities of these products and some lessons learned. JF - Expert opinion on biological therapy AU - Alayash, Abdu I AU - D'Agnillo, Felice AU - Buehler, Paul W AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Laboratory of Biochemistry and Vascular Biology, Division of Hematology, National Institutes of Health Campus, Bethesda, MD 20892, USA. abdu.alayash@fda.hhs.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 665 EP - 675 VL - 7 IS - 5 KW - Blood Substitutes KW - 0 KW - Hemoglobins KW - Reactive Oxygen Species KW - Recombinant Proteins KW - Nitric Oxide KW - 31C4KY9ESH KW - Index Medicus KW - Recombinant Proteins -- toxicity KW - Oxidation-Reduction KW - Molecular Structure KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Protein Engineering KW - Humans KW - Oxidative Stress -- drug effects KW - Nitric Oxide -- metabolism KW - Structure-Activity Relationship KW - Endothelial Cells -- drug effects KW - Blood Substitutes -- chemistry KW - Hemoglobins -- metabolism KW - Hemoglobins -- toxicity KW - Hemoglobins -- genetics KW - Hemoglobins -- chemistry KW - Drug Design KW - Blood Substitutes -- metabolism KW - Blood Substitutes -- toxicity KW - Endothelial Cells -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70454037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+biological+therapy&rft.atitle=First-generation+blood+substitutes%3A+what+have+we+learned%3F+Biochemical+and+physiological+perspectives.&rft.au=Alayash%2C+Abdu+I%3BD%27Agnillo%2C+Felice%3BBuehler%2C+Paul+W&rft.aulast=Alayash&rft.aufirst=Abdu&rft.date=2007-05-01&rft.volume=7&rft.issue=5&rft.spage=665&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+biological+therapy&rft.issn=1744-7682&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-24 N1 - Date created - 2007-05-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The uncoupled chloride conductance of a bacterial glutamate transporter homolog. AN - 70445608; 17435767 AB - Glutamate transporters (EAATs) are pivotal in mammalian synaptic transmission, tightly regulating synaptic levels of this excitatory neurotransmitter. In addition to coupled glutamate transport, the EAATs also show an uncoupled Cl(-) conductance, whose physiological importance has recently been demonstrated. Little is yet known about the molecular mechanism of chloride permeation. Here we show that Glt(Ph), a bacterial EAAT homolog whose structure has been determined, displays an uncoupled Cl(-) conductance that can determine the rate of substrate uptake. A mutation analogous to one known to specifically affect Cl(-) movement in EAAT1 has similar effects on Glt(Ph), suggesting that this protein is an excellent structural model for understanding Cl(-) permeation through the EAATs. We also observed an uncoupled Cl(-) conductance in another bacterial EAAT homolog but not in a homolog of the Na(+)/Cl(-)-coupled neurotransmitter transporters. JF - Nature structural & molecular biology AU - Ryan, Renae M AU - Mindell, Joseph A AD - Membrane Transport Biophysics Unit, Porter Neuroscience Center, National Institute of Neurological Disorders and Stroke, US National Institutes of Health, 35 Convent Drive, Building 35, MSC 3701, Bethesda, Maryland 20892, USA. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 365 EP - 371 VL - 14 IS - 5 SN - 1545-9993, 1545-9993 KW - Bacterial Proteins KW - 0 KW - Glutamate Plasma Membrane Transport Proteins KW - Aspartic Acid KW - 30KYC7MIAI KW - Chlorine KW - 4R7X1O2820 KW - Index Medicus KW - Aspartic Acid -- metabolism KW - Permeability KW - Kinetics KW - Mutation KW - Evolution, Molecular KW - Ion Transport KW - Glutamate Plasma Membrane Transport Proteins -- genetics KW - Glutamate Plasma Membrane Transport Proteins -- metabolism KW - Chlorine -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70445608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+structural+%26+molecular+biology&rft.atitle=The+uncoupled+chloride+conductance+of+a+bacterial+glutamate+transporter+homolog.&rft.au=Ryan%2C+Renae+M%3BMindell%2C+Joseph+A&rft.aulast=Ryan&rft.aufirst=Renae&rft.date=2007-05-01&rft.volume=14&rft.issue=5&rft.spage=365&rft.isbn=&rft.btitle=&rft.title=Nature+structural+%26+molecular+biology&rft.issn=15459993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-18 N1 - Date created - 2007-05-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Nat Struct Mol Biol. 2007 May;14(5):356-7 [17473876] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of the SPF10-LiPA system to the Hybrid Capture 2 Assay for detection of carcinogenic human papillomavirus genotypes among 5,683 young women in Guanacaste, Costa Rica. AN - 70444937; 17344361 AB - The objective of this analysis was to compare the performance characteristics of two human papillomavirus (HPV) DNA detections assays, the Hybrid Capture 2 assay (HC2) and the SPF(10) assay, for the detection of carcinogenic HPV. Data are from the enrollment visits of women who participated in the randomized, double-blind, placebo-controlled phase III HPV16/18 Vaccine Trial in Guanacaste, Costa Rica. We compared the results of HC2 and SPF(10) testing of cervical specimens. Since the line probe assay (LiPA) detection system does not distinguish between HPV type 68 (HPV68; which is targeted by HC2) and HPV73 (which is not targeted by HC2), for SPF(10)-LiPA, we defined the carcinogenic HPV types as the 12 HC2-targeted types (types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59), HPV68/73, and the HC2-cross-reactive, carcinogenic type HPV66. The kappa values and the performance characteristics for the detection of cervical abnormalities were ascertained. Paired observations were available for 5,683 sexually active, young women (median age, 21 years). The prevalence of carcinogenic HPV types was 35% (n=1,962) by HC2 and 35% (n=2,003) by SPF(10)-LiPA. There were no differences in the prevalence of carcinogenic HPV types by HC2 and SPF(10)-LiPA among women with normal, atypical squamous cells of undetermined significance and high-grade squamous intraepithelial lesion cytology. Among women with low-grade squamous intraepithelial lesion cytology, HC2 was more likely to test positive than SPF(10)-LiPA for the carcinogenic HPV types (87% and 79%, respectively; P=0.001) as a result of HC2 cross-reactivity with HPV types 40, 43, 44, 53, 54, 60, 70, and 74. The crude agreement between the two assays was 88%, with a kappa value of 0.75 (95% confidence limits, 0.73 to 0.76). We observed very good agreement between HC2 and SPF(10)-LiPA for carcinogenic HPV type detection. JF - Journal of clinical microbiology AU - Safaeian, Mahboobeh AU - Herrero, Rolando AU - Hildesheim, Allan AU - Quint, Wim AU - Freer, Enrique AU - Van Doorn, Leen-Jan AU - Porras, Carolina AU - Silva, Sandra AU - González, Paula AU - Bratti, M Concepcion AU - Rodriguez, Ana Cecilia AU - Castle, Philip AU - Costa Rican Vaccine Trial Group AD - Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, 6120 Executive Boulevard, Suite 550, Rockville, MD 20852, USA. safaeianm@mail.nih.gov ; Costa Rican Vaccine Trial Group Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 1447 EP - 1454 VL - 45 IS - 5 SN - 0095-1137, 0095-1137 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Sensitivity and Specificity KW - Genotype KW - Humans KW - Adult KW - Adolescent KW - Costa Rica -- epidemiology KW - Female KW - Human papillomavirus 18 -- genetics KW - Papillomavirus Infections -- epidemiology KW - Uterine Cervical Neoplasms -- epidemiology KW - Nucleic Acid Hybridization -- methods KW - Papillomavirus Infections -- virology KW - DNA, Viral -- isolation & purification KW - Human papillomavirus 16 -- genetics KW - Uterine Cervical Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70444937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+microbiology&rft.atitle=Comparison+of+the+SPF10-LiPA+system+to+the+Hybrid+Capture+2+Assay+for+detection+of+carcinogenic+human+papillomavirus+genotypes+among+5%2C683+young+women+in+Guanacaste%2C+Costa+Rica.&rft.au=Safaeian%2C+Mahboobeh%3BHerrero%2C+Rolando%3BHildesheim%2C+Allan%3BQuint%2C+Wim%3BFreer%2C+Enrique%3BVan+Doorn%2C+Leen-Jan%3BPorras%2C+Carolina%3BSilva%2C+Sandra%3BGonz%C3%A1lez%2C+Paula%3BBratti%2C+M+Concepcion%3BRodriguez%2C+Ana+Cecilia%3BCastle%2C+Philip%3BCosta+Rican+Vaccine+Trial+Group&rft.aulast=Safaeian&rft.aufirst=Mahboobeh&rft.date=2007-05-01&rft.volume=45&rft.issue=5&rft.spage=1447&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-13 N1 - Date created - 2007-05-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Microbiol. 2000 Jan;38(1):357-61 [10618116] Cancer Res. 2006 Oct 15;66(20):10112-9 [17047075] J Med Virol. 2001 Sep;65(1):155-62 [11505458] J Natl Cancer Inst. 2001 Sep 5;93(17):1349-50 [11535713] Cancer Epidemiol Biomarkers Prev. 2002 Nov;11(11):1394-9 [12433717] J Clin Virol. 2002 Dec;25 Suppl 3:S89-97 [12467782] J Natl Cancer Inst Monogr. 2003;(31):80-8 [12807950] Epidemiology. 1991 Mar;2(2):98-106 [1657209] IARC Sci Publ. 1992;(119):181-97 [1330909] Cancer Res. 1994 Apr 1;54(7 Suppl):1944s-1947s [7794294] J Natl Cancer Inst. 1995 Jun 7;87(11):796-802 [7791229] J Clin Microbiol. 1996 Mar;34(3):745-7 [8904451] J Clin Microbiol. 1998 Nov;36(11):3248-54 [9774574] Am J Pathol. 1998 Dec;153(6):1731-9 [9846964] J Clin Microbiol. 1999 Aug;37(8):2508-17 [10405393] J Pathol. 1999 Sep;189(1):12-9 [10451482] Lancet. 2004 Nov 13-19;364(9447):1757-65 [15541448] J Clin Virol. 2005 Apr;32(4):278-85 [15780805] Lancet Oncol. 2005 Apr;6(4):204 [15830458] Lancet Oncol. 2005 May;6(5):271-8 [15863374] J Infect Dis. 2005 Jun 1;191(11):1796-807 [15871111] Am J Clin Pathol. 2005 Nov;124(5):722-32 [16203281] Int J Cancer. 2006 Sep 1;119(5):1095-101 [16586444] Cancer Epidemiol Biomarkers Prev. 2006 Jul;15(7):1262-7 [16835321] J Clin Microbiol. 2006 Sep;44(9):3292-8 [16954263] JAMA. 2000 Jan 5;283(1):87-93 [10632285] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice. AN - 70426424; 17183066 AB - The farnesoid X receptor (FXR) controls the synthesis and transport of bile acids (BAs). Mice lacking expression of FXR, designated Fxr-null, have elevated levels of serum and hepatic BAs and an increase in BA pool size. Surprisingly, at 12 months of age, male and female Fxr-null mice had a high incidence of degenerative hepatic lesions, altered cell foci and liver tumors including hepatocellular adenoma, carcinoma and hepatocholangiocellular carcinoma, the latter of which is rarely observed in mice. At 3 months, Fxr-null mice had increased expression of the proinflammatory cytokine IL-1beta mRNA and elevated beta-catenin and its target gene c-myc. They also had increased cell proliferation as revealed by increased PCNA mRNA and BrdU incorporation. These studies reveal a potential role for FXR and BAs in hepatocarcinogenesis. JF - Carcinogenesis AU - Kim, Insook AU - Morimura, Keiichirou AU - Shah, Yatrik AU - Yang, Qian AU - Ward, Jerrold M AU - Gonzalez, Frank J AD - Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 940 EP - 946 VL - 28 IS - 5 SN - 0143-3334, 0143-3334 KW - Bile Acids and Salts KW - 0 KW - DNA-Binding Proteins KW - Interleukin-1beta KW - Receptors, Cytoplasmic and Nuclear KW - Transcription Factors KW - beta Catenin KW - farnesoid X-activated receptor KW - Index Medicus KW - Animals KW - Liver -- pathology KW - Interleukin-1beta -- analysis KW - Biological Transport KW - Gene Expression KW - Inflammation -- genetics KW - Mice KW - Cell Proliferation KW - Cholangiocarcinoma -- genetics KW - Mice, Mutant Strains KW - Carcinoma, Hepatocellular -- genetics KW - beta Catenin -- genetics KW - Cell Transformation, Neoplastic KW - Female KW - Male KW - Receptors, Cytoplasmic and Nuclear -- physiology KW - Transcription Factors -- physiology KW - Adenoma, Liver Cell -- genetics KW - DNA-Binding Proteins -- genetics KW - Receptors, Cytoplasmic and Nuclear -- genetics KW - DNA-Binding Proteins -- physiology KW - Transcription Factors -- genetics KW - Bile Acids and Salts -- metabolism KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70426424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Spontaneous+hepatocarcinogenesis+in+farnesoid+X+receptor-null+mice.&rft.au=Kim%2C+Insook%3BMorimura%2C+Keiichirou%3BShah%2C+Yatrik%3BYang%2C+Qian%3BWard%2C+Jerrold+M%3BGonzalez%2C+Frank+J&rft.aulast=Kim&rft.aufirst=Insook&rft.date=2007-05-01&rft.volume=28&rft.issue=5&rft.spage=940&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-09 N1 - Date created - 2007-04-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 1971 Oct;31(10):1506-12 [4328739] J Natl Cancer Inst. 1979 Sep;63(3):849-54 [288939] Proc Natl Acad Sci U S A. 1985 Nov;82(21):7232-6 [3903749] Prog Clin Biol Res. 1991;369:285-9 [1946525] Hepatology. 1992 Dec;16(6):1327-33 [1280243] Am J Pathol. 1994 Nov;145(5):1237-45 [7977654] Hepatology. 1995 May;21(5):1465-8 [7737654] Lab Invest. 1995 Sep;73(3):424-32 [7564276] FASEB J. 1997 Jan;11(1):19-28 [9034162] Gastroenterology. 1999 Jan;116(1):179-86 [9869616] J Clin Invest. 1999 Jan;103(1):137-45 [9884343] Carcinogenesis. 1999 Feb;20(2):299-303 [10069468] Int J Oncol. 1999 Aug;15(2):259-65 [10402235] Gastroenterology. 2004 Nov;127(5):1497-512 [15521018] Gastroenterology. 2005 Apr;128(4):1042-55 [15825085] Toxicol Sci. 2005 May;85(1):515-29 [15728704] J Pharmacol Exp Ther. 2005 Aug;314(2):584-95 [15860571] Front Biosci. 2006;11:889-98 [16146780] Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):1006-11 [16410358] EMBO J. 2006 Apr 5;25(7):1419-25 [16541101] Science. 2006 Apr 14;312(5771):233-6 [16614213] Mol Biol Cell. 2004 May;15(5):2156-63 [15004225] Surgery. 2004 Feb;135(2):215-21 [14739857] J Biol Chem. 2003 Dec 19;278(51):51085-90 [14527955] Hepatology. 2002 May;35(5):1041-52 [11981754] Gut. 2002 Jun;50(6):891-6 [12010897] J Clin Invest. 2003 Dec;112(11):1678-87 [14623915] Front Biosci. 2002 Apr 1;7:d808-26 [11897564] Hepatology. 2001 Nov;34(5):868-76 [11679956] Genes Dev. 2006 Sep 15;20(18):2527-38 [16980582] Trends Biochem Sci. 2006 Oct;31(10):572-80 [16908160] Mol Carcinog. 2006 Jun;45(6):355-61 [16673382] J Biol Chem. 2006 Apr 21;281(16):11039-49 [16446356] J Biol Chem. 2000 Jul 21;275(29):21805-8 [10823815] Cell. 2000 Sep 15;102(6):731-44 [11030617] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A pharmacokinetic and safety evaluation of an episcleral cyclosporine implant for potential use in high-risk keratoplasty rejection. AN - 70426286; 17460256 AB - To determine the short and long-term pharmacokinetics and assess the toxicity of a cyclosporine (CsA) episcleral implant for the prevention of high-risk keratoplasty rejection. CsA episcleral implants were made with a high (implant A) or low (implant B) release rate, and in vitro release rates were performed. Short-term pharmacokinetics were performed in rabbits using implant B, and the spatial and temporal spread of drug was observed by sampling from multiple corneal and conjunctival sites at 3 and 72 hours. Implant A was used in long-term pharmacokinetic studies in dogs aged more than 1 year. An ocular toxicity study was performed in dogs older than 1 year. A high release rate was observed with both implants over the initial 5 months followed by a steady state release. The cumulative release over the 400-day assay period from implants A and B was 3.8 +/- 0.3 and 2.3 +/- 0.3 mg, respectively. In the short-term pharmacokinetic studies, the cornea had CsA concentrations of 0.15 +/- 0.06, 0.07 +/- 0.02, and 0.05 +/- 0.02 microg/mg at sites centered 8, 13, and 18 mm away from the implant site, respectively. In the long-term pharmacokinetic studies, corneal CsA levels ranged from 0.18 +/- 0.06 to 0.009 +/- 0.004 microg/mg during the 1-year study. There were no signs of ocular toxicity at 1 year. Episcleral implants are safe and effective at delivering therapeutic CsA levels to the cornea to potentially prevent corneal allograft rejection. The implant can be surgically inserted at the time of penetrating keratoplasties, since the implant achieves therapeutic levels as early as 3 hours. JF - Investigative ophthalmology & visual science AU - Lee, Susan S AU - Kim, Hyuncheol AU - Wang, Nam Sun AU - Bungay, Peter M AU - Gilger, Brian C AU - Yuan, Peng AU - Kim, Jonghyeon AU - Csaky, Karl G AU - Robinson, Michael R AD - National Eye Institute, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA. susan.sh.lee@gmail.com Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 2023 EP - 2029 VL - 48 IS - 5 SN - 0146-0404, 0146-0404 KW - Drug Implants KW - 0 KW - Immunosuppressive Agents KW - Cyclosporine KW - 83HN0GTJ6D KW - Index Medicus KW - Lymph Nodes -- metabolism KW - Aqueous Humor -- metabolism KW - Animals KW - Conjunctiva -- metabolism KW - Dogs KW - Rabbits KW - Eyelids -- metabolism KW - Male KW - Female KW - Biological Availability KW - Sclera -- metabolism KW - Immunosuppressive Agents -- toxicity KW - Cyclosporine -- toxicity KW - Cornea -- metabolism KW - Keratoplasty, Penetrating KW - Immunosuppressive Agents -- pharmacokinetics KW - Graft Rejection -- prevention & control KW - Cyclosporine -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70426286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=A+pharmacokinetic+and+safety+evaluation+of+an+episcleral+cyclosporine+implant+for+potential+use+in+high-risk+keratoplasty+rejection.&rft.au=Lee%2C+Susan+S%3BKim%2C+Hyuncheol%3BWang%2C+Nam+Sun%3BBungay%2C+Peter+M%3BGilger%2C+Brian+C%3BYuan%2C+Peng%3BKim%2C+Jonghyeon%3BCsaky%2C+Karl+G%3BRobinson%2C+Michael+R&rft.aulast=Lee&rft.aufirst=Susan&rft.date=2007-05-01&rft.volume=48&rft.issue=5&rft.spage=2023&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=01460404&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-13 N1 - Date created - 2007-04-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Uses of and exposure to trichloroethylene in U.S. industry: a systematic literature review. AN - 70414337; 17454505 AB - This article describes a systematic review of the industrial hygiene literature for uses of trichloroethylene (TCE) in industry for the exposure assessment of two population-based case control studies of brain cancer in the United States. Papers and reports that address uses of and exposures to TCE were identified from MEDLINE, TOXLINE, NIOSHTIC, the NIOSH Health Hazard Evaluation database (keywords: chlorinated solvents and trichloroethylene), and in other reviews. This search was complemented by reviewing the reference lists from the identified literature. The collected information was systematized by the Standard Industrial Classification (SIC) system, and measurement data reported in the literature were summarized in a database. TCE use was extensive from the early 1920s through the 1970s mainly as a degreasing agent in metal-fabricating operations. After the 1970s it became less popular because of environmental concerns. TCE historically has had a multitude of uses in many other industries, e.g., dry cleaning, textile, electronics, leather, and rubber. Also, many products like adhesives, drugs, paints, inks, and various industrial products have contained TCE. It was banned as a food additive and in cosmetics in 1977. The arithmetic mean (AM) of the measurements across all industries and decades was 38.2 ppm. The highest personal and area air levels were reported in vapor degreasing (AM of 44.6 ppm). Most TCE measurements were performed in the 1950s, 1970s, and 1980s. The data described here could be used by exposure assessors as is to identify the presence and approximate levels of exposure. Using the same information as a basis should increase the reliability of the assessments, making it easier to compare both the exposure assessment methods and the epidemiologic results across different studies. JF - Journal of occupational and environmental hygiene AU - Bakke, Berit AU - Stewart, Patricia A AU - Waters, Martha A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 375 EP - 390 VL - 4 IS - 5 SN - 1545-9624, 1545-9624 KW - Solvents KW - 0 KW - Trichloroethylene KW - 290YE8AR51 KW - Index Medicus KW - United States KW - Animals KW - Humans KW - Occupational Exposure KW - Solvents -- toxicity KW - Solvents -- analysis KW - Trichloroethylene -- analysis KW - Trichloroethylene -- toxicity KW - Industry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70414337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Uses+of+and+exposure+to+trichloroethylene+in+U.S.+industry%3A+a+systematic+literature+review.&rft.au=Bakke%2C+Berit%3BStewart%2C+Patricia+A%3BWaters%2C+Martha+A&rft.aulast=Bakke&rft.aufirst=Berit&rft.date=2007-05-01&rft.volume=4&rft.issue=5&rft.spage=375&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=15459624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-25 N1 - Date created - 2007-04-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neuroprotective actions of a histidine analogue in models of ischemic stroke. AN - 70408828; 17254011 AB - Histidine is a naturally occurring amino acid with antioxidant properties, which is present in low amounts in tissues throughout the body. We recently synthesized and characterized histidine analogues related to the natural dipeptide carnosine, which selectively scavenge the toxic lipid peroxidation product 4-hydroxynonenal (HNE). We now report that the histidine analogue histidyl hydrazide is effective in reducing brain damage and improving functional outcome in a mouse model of focal ischemic stroke when administered intravenously at a dose of 20 mg/kg, either 30 min before or 60 min and 3 h after the onset of middle cerebral artery occlusion. The histidine analogue also protected cultured rat primary neurons against death induced by HNE, chemical hypoxia, glucose deprivation, and combined oxygen and glucose deprivation. The histidine analogue prevented neuronal apoptosis as indicated by decreased production of cleaved caspase-3 protein. These findings suggest a therapeutic potential for HNE-scavenging histidine analogues in the treatment of stroke and related neurodegenerative conditions. JF - Journal of neurochemistry AU - Tang, Sung-Chun AU - Arumugam, Thiruma V AU - Cutler, Roy G AU - Jo, Dong-Gyu AU - Magnus, Tim AU - Chan, Sic L AU - Mughal, Mohamed R AU - Telljohann, Richard S AU - Nassar, Matthew AU - Ouyang, Xin AU - Calderan, Andrea AU - Ruzza, Paolo AU - Guiotto, Andrea AU - Mattson, Mark P AD - Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 729 EP - 736 VL - 101 IS - 3 SN - 0022-3042, 0022-3042 KW - AG-01 compound KW - 0 KW - Neuroprotective Agents KW - Histidine KW - 4QD397987E KW - Carnosine KW - 8HO6PVN24W KW - Caspase 3 KW - EC 3.4.22.- KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Animals KW - Carnosine -- analogs & derivatives KW - Neurons -- drug effects KW - Disease Models, Animal KW - Mice KW - Cell Death -- drug effects KW - Glucose -- deficiency KW - Rats KW - Animals, Newborn KW - Brain Infarction -- drug therapy KW - Rats, Sprague-Dawley KW - Hypoxia -- drug therapy KW - Cells, Cultured KW - Mice, Inbred C57BL KW - Chromatography, High Pressure Liquid -- methods KW - Mass Spectrometry -- methods KW - Brain Infarction -- etiology KW - Carnosine -- therapeutic use KW - Time Factors KW - Male KW - Caspase 3 -- metabolism KW - Infarction, Middle Cerebral Artery -- prevention & control KW - Infarction, Middle Cerebral Artery -- complications KW - Neuroprotective Agents -- metabolism KW - Histidine -- analogs & derivatives KW - Neuroprotective Agents -- therapeutic use KW - Histidine -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70408828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Neuroprotective+actions+of+a+histidine+analogue+in+models+of+ischemic+stroke.&rft.au=Tang%2C+Sung-Chun%3BArumugam%2C+Thiruma+V%3BCutler%2C+Roy+G%3BJo%2C+Dong-Gyu%3BMagnus%2C+Tim%3BChan%2C+Sic+L%3BMughal%2C+Mohamed+R%3BTelljohann%2C+Richard+S%3BNassar%2C+Matthew%3BOuyang%2C+Xin%3BCalderan%2C+Andrea%3BRuzza%2C+Paolo%3BGuiotto%2C+Andrea%3BMattson%2C+Mark+P&rft.aulast=Tang&rft.aufirst=Sung-Chun&rft.date=2007-05-01&rft.volume=101&rft.issue=3&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-18 N1 - Date created - 2007-04-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Induction of IL-13 triggers TGF-beta1-dependent tissue fibrosis in chronic 2,4,6-trinitrobenzene sulfonic acid colitis. AN - 70396792; 17442970 AB - To investigate the immunopathogenesis of inflammation-associated fibrosis, we analyzed the chronic colitis and late-developing fibrosis occurring in BALB/c mice administered weekly doses of intrarectal 2,4,6-trinitrobenzene sulfonic acid. We showed first in this model that an initial Th1 response involving IL-12p70 and IFN-gamma subsides after 3 wk to be supplanted by an IL-23/IL-25 response beginning after 4-5 wk. This evolution is followed by gradually increasing production of IL-17 and cytokines ordinarily seen in a Th2 response, particularly IL-13, which reaches a plateau at 8-9 wk. In vitro stimulation studies suggest that this IL-13 production is dependent on IL-23 and IL-25, but not on IL-12p70. We then show that IL-13 production results in the induction of an IL-13R formerly thought to function only as a decoy receptor, IL-13Ralpha(2), and this receptor is critical to the production of TGF-beta(1) and the onset of fibrosis. Thus, if IL-13 signaling through this receptor is blocked by administration of soluble IL-13Ralpha(2)-Fc, or by administration of IL-13Ralpha(2)-specific small interfering RNA, TGF-beta(1) is not produced and fibrosis does not occur. These studies show that in chronic 2,4,6-trinitrobenzene sulfonic acid colitis, fibrosis is dependent on the development of an IL-13 response that acts through a novel cell surface-expressed IL-13R to induce TGF-beta(1). A similar mechanism may obtain in certain forms of human inflammatory bowel disease. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Fichtner-Feigl, Stefan AU - Fuss, Ivan J AU - Young, Cheryl A AU - Watanabe, Tomohiro AU - Geissler, Edward K AU - Schlitt, Hans-Jürgen AU - Kitani, Atsushi AU - Strober, Warren AD - Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. stefan.fichtner@klinik.uni-regensburg.de Y1 - 2007/05/01/ PY - 2007 DA - 2007 May 01 SP - 5859 EP - 5870 VL - 178 IS - 9 SN - 0022-1767, 0022-1767 KW - Interleukin-13 KW - 0 KW - Interleukin-13 Receptor alpha2 Subunit KW - Interleukins KW - RNA, Small Interfering KW - Receptors, Interleukin-13 KW - Smad3 Protein KW - Smad7 Protein KW - Smad7 protein, mouse KW - Transforming Growth Factor beta1 KW - Interferon-gamma KW - 82115-62-6 KW - Trinitrobenzenesulfonic Acid KW - 8T3HQG2ZC4 KW - Abridged Index Medicus KW - Index Medicus KW - Trinitrobenzenesulfonic Acid -- toxicity KW - Th1 Cells -- immunology KW - Animals KW - Fibrosis KW - Interleukins -- metabolism KW - Mice KW - Mice, Inbred BALB C KW - Interleukins -- genetics KW - Interleukin-13 Receptor alpha2 Subunit -- metabolism KW - Phosphorylation KW - Interleukin-13 Receptor alpha2 Subunit -- antagonists & inhibitors KW - Smad3 Protein -- metabolism KW - Interleukin-13 Receptor alpha2 Subunit -- genetics KW - Interferon-gamma -- metabolism KW - RNA, Small Interfering -- pharmacology KW - Smad7 Protein -- metabolism KW - Colitis -- immunology KW - Transforming Growth Factor beta1 -- metabolism KW - Interleukin-13 -- metabolism KW - Receptors, Interleukin-13 -- genetics KW - Receptors, Interleukin-13 -- metabolism KW - Receptors, Interleukin-13 -- antagonists & inhibitors KW - Colitis -- pathology KW - Colitis -- chemically induced KW - Transforming Growth Factor beta1 -- genetics KW - Interleukin-13 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70396792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Induction+of+IL-13+triggers+TGF-beta1-dependent+tissue+fibrosis+in+chronic+2%2C4%2C6-trinitrobenzene+sulfonic+acid+colitis.&rft.au=Fichtner-Feigl%2C+Stefan%3BFuss%2C+Ivan+J%3BYoung%2C+Cheryl+A%3BWatanabe%2C+Tomohiro%3BGeissler%2C+Edward+K%3BSchlitt%2C+Hans-J%C3%BCrgen%3BKitani%2C+Atsushi%3BStrober%2C+Warren&rft.aulast=Fichtner-Feigl&rft.aufirst=Stefan&rft.date=2007-05-01&rft.volume=178&rft.issue=9&rft.spage=5859&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-18 N1 - Date created - 2007-04-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characterization of a novel two-partner secretion system in Escherichia coli O157:H7. AN - 70394213; 17322314 AB - Gram-negative bacteria contain multiple secretion pathways that facilitate the translocation of proteins across the outer membrane. The two-partner secretion (TPS) system is composed of two essential components, a secreted exoprotein and a pore-forming beta barrel protein that is thought to transport the exoprotein across the outer membrane. A putative TPS system was previously described in the annotation of the genome of Escherichia coli O157:H7 strain EDL933. We found that the two components of this system, which we designate OtpA and OtpB, are not predicted to belong to either of the two major subtypes of TPS systems (hemolysins and adhesins) based on their sequences. Nevertheless, we obtained direct evidence that OtpA and OtpB constitute a bona fide TPS system. We found that secretion of OtpA into the extracellular environment in E. coli O157:H7 requires OtpB and that when OtpA was produced in an E. coli K-12 strain, its secretion was strictly dependent on the production of OtpB. Furthermore, using OtpA/OtpB as a model system, we show that protein secretion via the TPS pathway is extremely rapid. JF - Journal of bacteriology AU - Choi, Peter S AU - Dawson, Ashley J AU - Bernstein, Harris D AD - Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0538, USA. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 3452 EP - 3461 VL - 189 IS - 9 SN - 0021-9193, 0021-9193 KW - Escherichia coli Proteins KW - 0 KW - Hemolysin Proteins KW - Index Medicus KW - Phylogeny KW - Cell Fractionation KW - Blotting, Western KW - Molecular Sequence Data KW - Genetic Complementation Test KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - Mutagenesis, Insertional KW - Gene Deletion KW - Escherichia coli Proteins -- chemistry KW - Escherichia coli Proteins -- metabolism KW - Protein Transport -- genetics KW - Escherichia coli O157 -- metabolism KW - Hemolysin Proteins -- metabolism KW - Escherichia coli O157 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70394213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Characterization+of+a+novel+two-partner+secretion+system+in+Escherichia+coli+O157%3AH7.&rft.au=Choi%2C+Peter+S%3BDawson%2C+Ashley+J%3BBernstein%2C+Harris+D&rft.aulast=Choi&rft.aufirst=Peter&rft.date=2007-05-01&rft.volume=189&rft.issue=9&rft.spage=3452&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-29 N1 - Date created - 2007-04-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochem Biophys Res Commun. 1990 Mar 16;167(2):711-5 [2182019] J Bacteriol. 1990 Mar;172(3):1206-16 [2407716] J Bacteriol. 1996 Feb;178(4):1053-60 [8576038] Mol Microbiol. 1995 Dec;18(5):821-30 [8825086] Genes Dev. 1996 Dec 15;10(24):3170-82 [8985185] J Bacteriol. 1997 Feb;179(3):775-83 [9006033] Cell. 1997 Jan 24;88(2):187-96 [9008159] Mol Microbiol. 1997 May;24(4):851-6 [9194711] Mol Microbiol. 1997 Dec;26(5):853-65 [9426124] Mol Microbiol. 1998 Feb;27(3):617-30 [9489673] J Biol Chem. 1998 May 15;273(20):12451-6 [9575202] Mol Microbiol. 1999 Jun;32(6):1212-25 [10383762] Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):221-6 [15615856] Biochemistry. 2005 Feb 1;44(4):1329-37 [15667226] J Clin Microbiol. 2005 Aug;43(8):3840-50 [16081921] Science. 2005 Aug 19;309(5738):1245-8 [16109881] J Biol Chem. 2006 Jan 6;281(1):158-66 [16284399] Infect Immun. 2006 Apr;74(4):2245-58 [16552055] Environ Microbiol. 2006 Apr;8(4):639-47 [16584475] Environ Microbiol. 2006 Jun;8(6):1033-47 [16689724] Mol Microbiol. 2006 Jul;61(2):368-82 [16771844] Infect Immun. 1990 Jun;58(6):1861-9 [2341182] J Bacteriol. 1992 Aug;174(15):5086-94 [1629165] Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2875-9 [8464902] Infect Immun. 1994 Sep;62(9):3881-9 [8063405] Mol Microbiol. 1993 Sep;9(6):1229-37 [7934936] J Biol Chem. 1999 Dec 31;274(53):37731-5 [10608832] Mol Microbiol. 2000 Apr;36(1):55-67 [10760163] Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6640-5 [10829079] Nature. 2001 Jan 25;409(6819):529-33 [11206551] DNA Res. 2001 Feb 28;8(1):11-22 [11258796] Mol Microbiol. 2001 Apr;40(2):306-13 [11309114] Biochemistry. 2001 Nov 13;40(45):13607-16 [11695909] Mol Microbiol. 2001 Oct;42(2):279-92 [11703654] J Bacteriol. 2002 Jul;184(14):3871-8 [12081958] Infect Immun. 2002 Oct;70(10):5416-27 [12228266] Infect Immun. 2002 Dec;70(12):6761-9 [12438351] J Biol Chem. 2002 Dec 27;277(52):51077-83 [12403776] Mol Microbiol. 2003 May;48(3):737-51 [12694618] Infect Immun. 2004 Jan;72(1):611-4 [14688146] Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6194-9 [15079085] FEMS Microbiol Lett. 2004 Sep 15;238(2):333-44 [15358418] Mol Genet Genomics. 2004 Sep;272(2):204-15 [15316770] Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14497-502 [15381771] J Mol Biol. 1976 Jul 5;104(3):541-55 [781293] Infect Immun. 1986 Jun;52(3):695-701 [2872165] J Bacteriol. 1987 May;169(5):2113-20 [2437098] J Biol Chem. 1989 Sep 25;264(27):16311-20 [2674128] J Bacteriol. 1995 Jul;177(14):4121-30 [7608087] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anthrax edema toxin sensitizes DBA/2J mice to lethal toxin. AN - 70393608; 17339348 AB - Anthrax toxin is made up of three separate protein components: the receptor-binding protective antigen (PA), the adenylyl cyclase edema factor (EF), and the metalloproteinase lethal factor (LF). EF and PA constitute edema toxin (ET), which causes edema when injected subcutaneously. At higher doses, ET causes severe pathologies and death in BALB/cJ mice (A. M. Firoved et al., Am. J. Pathol. 167:1309-1320, 2005). A striking effect of ET at lethal doses is adrenal necrosis. Here we show that low doses of ET (10 microg) that produce no overt signs of illness in mice still cause substantial adrenal lesions. These lesions are not associated with reduced corticosterone production; instead, ET-treated mice have increased corticosterone production. Because the resistance of mice to the other component of anthrax toxin, lethal toxin (LT; LF plus PA), has been shown to be overcome by the perturbation of the endocrine system, we hypothesized that sublethal doses of ET might sensitize LT-resistant DBA/2J mice to LT-mediated lethality. We report that a low dose of ET (5 microg) is sufficient to sensitize DBA/2J mice when given concurrently with LT. Higher doses of ET (e.g., 15 microg) given to male and female DBA/2J mice 18 h prior to LT challenge also sensitize them to LT. This study using highly purified ET and LT demonstrates how the components of anthrax toxin can work together to increase lethality. JF - Infection and immunity AU - Firoved, Aaron M AU - Moayeri, Mahtab AU - Wiggins, Jason F AU - Shen, Yuequan AU - Tang, Wei-Jen AU - Leppla, Stephen H AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, 30 Convent Dr., Building 30, Room 303, Bethesda, MD 20892-4349, USA. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 2120 EP - 2125 VL - 75 IS - 5 SN - 0019-9567, 0019-9567 KW - Antigens, Bacterial KW - 0 KW - Bacterial Toxins KW - anthrax toxin KW - Metalloproteases KW - EC 3.4.- KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Corticosterone KW - W980KJ009P KW - Index Medicus KW - Metalloproteases -- metabolism KW - Animals KW - Metalloproteases -- chemistry KW - Corticosterone -- blood KW - Bacillus anthracis -- pathogenicity KW - Bacillus anthracis -- metabolism KW - Mice KW - Mice, Inbred BALB C KW - Adrenal Glands -- pathology KW - Male KW - Female KW - Edema -- etiology KW - Mice, Inbred DBA KW - Antigens, Bacterial -- toxicity KW - Adenylyl Cyclases -- toxicity KW - Bacterial Toxins -- toxicity KW - Antigens, Bacterial -- administration & dosage KW - Bacterial Toxins -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70393608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Anthrax+edema+toxin+sensitizes+DBA%2F2J+mice+to+lethal+toxin.&rft.au=Firoved%2C+Aaron+M%3BMoayeri%2C+Mahtab%3BWiggins%2C+Jason+F%3BShen%2C+Yuequan%3BTang%2C+Wei-Jen%3BLeppla%2C+Stephen+H&rft.aulast=Firoved&rft.aufirst=Aaron&rft.date=2007-05-01&rft.volume=75&rft.issue=5&rft.spage=2120&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-14 N1 - Date created - 2007-04-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nature. 2001 Nov 8;414(6860):225-9 [11700562] Biochem J. 2000 Dec 15;352 Pt 3:739-45 [11104681] J Biol Chem. 2003 Jul 11;278(28):25990-7 [12676933] J Clin Invest. 2003 Sep;112(5):670-82 [12952916] Annu Rev Cell Dev Biol. 2003;19:45-70 [14570563] Am J Pathol. 2003 Nov;163(5):1735-41 [14578173] Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3242-7 [14978283] Infect Immun. 2004 Aug;72(8):4439-47 [15271901] Proc Natl Acad Sci U S A. 1982 May;79(10):3162-6 [6285339] Infect Immun. 1994 Oct;62(10):4432-9 [7927706] Mol Med. 1998 Feb;4(2):87-95 [9508786] Science. 1998 May 1;280(5364):734-7 [9563949] J Gen Microbiol. 1961 Sep;26:49-63 [13916257] Rev Physiol Biochem Pharmacol. 2004;152:135-64 [15549606] J Immunol. 2005 Apr 15;174(8):4934-41 [15814721] Infect Immun. 2005 Jul;73(7):4238-44 [15972515] Biochem Biophys Res Commun. 2005 Sep 30;335(3):850-7 [16099427] Am J Pathol. 2005 Nov;167(5):1309-20 [16251415] Nat Genet. 2006 Feb;38(2):240-4 [16429160] Mol Microbiol. 2006 Jul;61(2):324-37 [16856939] Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5170-4 [12700348] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tolcapone improves cognition and cortical information processing in normal human subjects. AN - 70390343; 17063156 AB - Prefrontal cortical dopamine (DA) regulates various executive cognitive functions, including attention and working memory. Efforts to enhance prefrontal-related cognition, which have focused on catecholaminergic stimulant drugs, have been unsatisfactory. Recently, the demonstration that a functional polymorphism in the catecholamine-O-methyltransferase (COMT) gene impacts prefrontal cognition raises the possibility of a novel pharmacological approach for the treatment of prefrontal lobe executive dysfunction. To explore in a proof of concept study the effects of tolcapone, a CNS penetrant specific COMT inhibitor, we performed a randomized, double blind, placebo controlled, and crossover design of this drug in normal subjects stratified by COMT (val158met) genotype. COMT enzyme activity was determined in peripheral blood. Forty-seven normal volunteers with no family history of psychiatric disorders underwent neuropsychological testing and 34 of those subjects underwent physiological measurement of prefrontal information processing assessed by blood oxygen level-dependent functional magnetic resonance imaging (fMRI). We found significant drug effects on measures of executive function and verbal episodic memory and a significant drug by genotype interaction on the latter, such that individuals with val/val genotypes improved, whereas individuals with met/met genotypes worsened on tolcapone. fMRI revealed a significant tolcapone-induced improvement in the efficiency of information processing in prefrontal cortex during a working memory test. This study demonstrates enhancement of prefrontal cortical function in normal human subjects with a nonstimulant drug having COMT inhibitory activity. Our results are consistent with data from animal studies and from computational models of the effects of selective enhancement of DA signaling in the prefrontal cortex. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Apud, José A AU - Mattay, Venkata AU - Chen, Jingshan AU - Kolachana, Bhaskar S AU - Callicott, Joseph H AU - Rasetti, Roberta AU - Alce, Guilna AU - Iudicello, Jennifer E AU - Akbar, Natkai AU - Egan, Michael F AU - Goldberg, Terry E AU - Weinberger, Daniel R AD - Genes, Cognition and Psychosis Program, Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20854, USA. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 1011 EP - 1020 VL - 32 IS - 5 SN - 0893-133X, 0893-133X KW - Benzophenones KW - 0 KW - Catechol O-Methyltransferase Inhibitors KW - Enzyme Inhibitors KW - Nitrophenols KW - Placebos KW - tolcapone KW - CIF6334OLY KW - Catechol O-Methyltransferase KW - EC 2.1.1.6 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Catechol O-Methyltransferase -- genetics KW - Enzyme Inhibitors -- adverse effects KW - Reference Values KW - Double-Blind Method KW - Humans KW - Genotype KW - Brain Mapping KW - Amino Acid Substitution -- genetics KW - Adult KW - Treatment Outcome KW - Cross-Over Studies KW - Enzyme Inhibitors -- pharmacology KW - Middle Aged KW - Neuropsychological Tests KW - Male KW - Female KW - Catechol O-Methyltransferase -- metabolism KW - Cognition -- physiology KW - Benzophenones -- adverse effects KW - Nitrophenols -- adverse effects KW - Prefrontal Cortex -- metabolism KW - Cognition -- drug effects KW - Memory -- drug effects KW - Nitrophenols -- pharmacology KW - Benzophenones -- pharmacology KW - Prefrontal Cortex -- physiology KW - Memory -- physiology KW - Prefrontal Cortex -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70390343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Tolcapone+improves+cognition+and+cortical+information+processing+in+normal+human+subjects.&rft.au=Apud%2C+Jos%C3%A9+A%3BMattay%2C+Venkata%3BChen%2C+Jingshan%3BKolachana%2C+Bhaskar+S%3BCallicott%2C+Joseph+H%3BRasetti%2C+Roberta%3BAlce%2C+Guilna%3BIudicello%2C+Jennifer+E%3BAkbar%2C+Natkai%3BEgan%2C+Michael+F%3BGoldberg%2C+Terry+E%3BWeinberger%2C+Daniel+R&rft.aulast=Apud&rft.aufirst=Jos%C3%A9&rft.date=2007-05-01&rft.volume=32&rft.issue=5&rft.spage=1011&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-05 N1 - Date created - 2007-04-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2. AN - 70388783; 17384642 AB - Transforming growth factor-beta1 (TGF-beta1) regulates inflammation and can inhibit activation of the transcription factor NF-kappaB in certain cell types. Here we show that the TGF-beta-induced signaling protein Smad7 bound to TAB2 and TAB3, which are adaptors that link the kinase TAK1 to 'upstream' regulators in the proinflammatory tumor necrosis factor (TNF) signaling pathway. Smad7 thereby promoted TGF-beta-mediated anti-inflammatory effects. The formation of Smad7-TAB2 and Smad7-TAB3 complexes resulted in the suppression of TNF signaling through the adaptors TRAF2, TAB2 and/or TAB3, and TAK1. Furthermore, expression of a transgene encoding Smad7 in mouse skin suppressed inflammation and NF-kappaB nuclear translocation substantially and disrupted the formation of endogenous TRAF2-TAK1-TAB2 and TRAF2-TAK1-TAB3 complexes. Thus, Smad7 is a critical mediator of TGF-beta signals that block proinflammatory TNF signals. JF - Nature immunology AU - Hong, Suntaek AU - Lim, Seunghwan AU - Li, Allen G AU - Lee, Chan AU - Lee, Youn Sook AU - Lee, Eun-Kyung AU - Park, Seok Hee AU - Wang, Xiao-Jing AU - Kim, Seong-Jin AD - Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892-50551, USA. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 504 EP - 513 VL - 8 IS - 5 SN - 1529-2908, 1529-2908 KW - Adaptor Proteins, Signal Transducing KW - 0 KW - Intracellular Signaling Peptides and Proteins KW - SMAD7 protein, human KW - Smad7 Protein KW - TAB3 protein, human KW - TNF Receptor-Associated Factor 2 KW - Tumor Necrosis Factor-alpha KW - MAP Kinase Kinase Kinases KW - EC 2.7.11.25 KW - MAP kinase kinase kinase 7 KW - Index Medicus KW - MAP Kinase Kinase Kinases -- metabolism KW - TNF Receptor-Associated Factor 2 -- metabolism KW - Cells, Cultured KW - Intracellular Signaling Peptides and Proteins -- metabolism KW - Tumor Necrosis Factor-alpha -- physiology KW - Smad7 Protein -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70388783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+immunology&rft.atitle=Smad7+binds+to+the+adaptors+TAB2+and+TAB3+to+block+recruitment+of+the+kinase+TAK1+to+the+adaptor+TRAF2.&rft.au=Hong%2C+Suntaek%3BLim%2C+Seunghwan%3BLi%2C+Allen+G%3BLee%2C+Chan%3BLee%2C+Youn+Sook%3BLee%2C+Eun-Kyung%3BPark%2C+Seok+Hee%3BWang%2C+Xiao-Jing%3BKim%2C+Seong-Jin&rft.aulast=Hong&rft.aufirst=Suntaek&rft.date=2007-05-01&rft.volume=8&rft.issue=5&rft.spage=504&rft.isbn=&rft.btitle=&rft.title=Nature+immunology&rft.issn=15292908&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-17 N1 - Date created - 2007-04-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Nat Immunol. 2007 May;8(5):477-8 [17440456] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Safety of intracerebroventricular copper histidine in adult rats. AN - 70387684; 17336116 AB - Classical Menkes disease is an X-linked recessive neurodegenerative disorder caused by mutations in a P-type ATPase (ATP7A) that normally delivers copper to the developing central nervous system. Infants with large deletions, or other mutations in ATP7A that incapacitate copper transport to the brain, show poor clinical outcomes and subnormal brain copper despite early subcutaneous copper histidine (CuHis) injections. These findings suggest a need for direct central nervous system approaches in such patients. To begin to evaluate an aggressive but potentially useful new strategy for metabolic improvement of this disorder, we studied the acute and chronic effects of CuHis administered by intracerebroventricular (ICV) injection in healthy adult rats. Magnetic resonance imaging (MRI) after ICV CuHis showed diffuse T(1)-signal enhancement, indicating wide brain distribution of copper after ICV administration, and implying the utility of this paramagnetic metal as a MRI contrast agent. The maximum tolerated dose (MTD) of CuHis, defined as the highest dose that did not induce overt toxicity, growth retardation, or reduce lifespan, was 0.5mcg. Animals receiving multiple infusions of this MTD showed increased brain copper concentrations, but no significant differences in activity, behavior, and somatic growth, or brain histology compared to saline-injected controls. Based on estimates of the brain copper deficit in Menkes disease patients, CuHis doses 10-fold lower than the MTD found in this study may restore proper brain copper concentration. Our results suggest that ICV CuHis administration have potential as a novel treatment approach in Menkes disease infants with severe mutations. Future trials of direct CNS copper administration in mouse models of Menkes disease will be informative. JF - Molecular genetics and metabolism AU - Lem, Kristen E AU - Brinster, Lauren R AU - Tjurmina, Olga AU - Lizak, Martin AU - Lal, Simina AU - Centeno, Jose A AU - Liu, Po-Ching AU - Godwin, Sarah C AU - Kaler, Stephen G AD - Unit on Pediatric Genetics, Laboratory of Clinical Genomics, National Institute of Child Health and Human Development, Bethesda, MD, USA. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 30 EP - 36 VL - 91 IS - 1 SN - 1096-7192, 1096-7192 KW - Organometallic Compounds KW - 0 KW - Histidine KW - 4QD397987E KW - copper histidine KW - 77280-83-2 KW - Index Medicus KW - Rats KW - Magnetic Resonance Imaging KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Brain Edema -- chemically induced KW - Radiography KW - Maximum Tolerated Dose KW - Menkes Kinky Hair Syndrome -- drug therapy KW - Time Factors KW - Male KW - Injections, Intraventricular KW - Brain Edema -- pathology KW - Histidine -- administration & dosage KW - Organometallic Compounds -- administration & dosage KW - Brain -- pathology KW - Brain -- drug effects KW - Organometallic Compounds -- toxicity KW - Histidine -- toxicity KW - Histidine -- analogs & derivatives KW - Brain -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70387684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+genetics+and+metabolism&rft.atitle=Safety+of+intracerebroventricular+copper+histidine+in+adult+rats.&rft.au=Lem%2C+Kristen+E%3BBrinster%2C+Lauren+R%3BTjurmina%2C+Olga%3BLizak%2C+Martin%3BLal%2C+Simina%3BCenteno%2C+Jose+A%3BLiu%2C+Po-Ching%3BGodwin%2C+Sarah+C%3BKaler%2C+Stephen+G&rft.aulast=Lem&rft.aufirst=Kristen&rft.date=2007-05-01&rft.volume=91&rft.issue=1&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Molecular+genetics+and+metabolism&rft.issn=10967192&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-25 N1 - Date created - 2007-04-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 1987 Nov 26;317(22):1415-6 [3683474] Neuroimage. 2004 Jul;22(3):1046-59 [15219577] Nat Genet. 1993 Jan;3(1):14-9 [8490646] Nat Genet. 1993 Jan;3(1):20-5 [8490647] Nat Genet. 1993 Jan;3(1):7-13 [8490659] Exp Neurol. 1994 May;127(1):23-36 [8200435] Adv Pediatr. 1994;41:263-304 [7992686] Nature. 1995 Apr 13;374(6523):643-6 [7715704] Ann Neurol. 1995 Dec;38(6):921-8 [8526465] Brain Res. 1995 Oct 9;695(1):53-8 [8574647] Nat Genet. 1996 May;13(1):21-2 [8673098] Biochem Mol Med. 1996 Feb;57(1):37-46 [8812725] J Neurochem. 1999 Jan;72(1):422-9 [9886096] Pediatrics. 2005 Feb;115(2):286-94 [15687434] Magn Reson Med. 2005 Mar;53(3):640-8 [15723400] Brain Res Mol Brain Res. 2005 Apr 4;134(2):323-32 [15836927] Mol Genet Metab. 2005 Aug;85(4):291-300 [15923132] Neuroscience. 2006;139(3):947-64 [16549268] Brain Res. 2000 Apr 28;863(1-2):241-4 [10773212] J Biol Chem. 2000 Aug 18;275(33):25057-60 [10816601] Mol Cell Biol. 2002 Nov;22(21):7614-21 [12370308] J Med Genet. 2003 Apr;40(4):290-5 [12676902] Magn Reson Med. 2004 May;51(5):978-87 [15122680] J Biol Chem. 1988 Jan 15;263(2):799-805 [3335527] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neurobehavioral development in children with potential exposure to pesticides. AN - 70386366; 17435439 AB - Children may be at higher risk than adults from pesticide exposure, due to their rapidly developing physiology, unique behavioral patterns, and interactions with the physical environment. This preliminary study conducted in Ecuador examines the association between household and environmental risk factors for pesticide exposure and neurobehavioral development. We collected data over 6 months in the rural highland region of Cayambe, Ecuador (2003-2004). Children age 24-61 months residing in 3 communities were assessed with the Ages and Stages Questionnaire and the Visual Motor Integration Test. We gathered information on maternal health and work characteristics, the home and community environment, and child characteristics. Growth measurements and a hemoglobin finger-prick blood test were obtained. Multiple linear regression analyses were conducted. Current maternal employment in the flower industry was associated with better developmental scores. Longer hours playing outdoors were associated with lower gross and fine motor and problem solving skills. Children who played with irrigation water scored lower on fine motor skills (8% decrease; 95% confidence interval = -9.31 to -0.53), problem-solving skills (7% decrease; -8.40 to -0.39), and Visual Motor Integration test scores (3% decrease; -12.00 to 1.08). These results suggest that certain environmental risk factors for exposure to pesticides may affect child development, with contact with irrigation water of particular concern. However, the relationships between these risk factors and social characteristics are complex, as corporate agriculture may increase risk through pesticide exposure and environmental contamination, while indirectly promoting healthy development by providing health care, relatively higher salaries, and daycare options. JF - Epidemiology (Cambridge, Mass.) AU - Handal, Alexis J AU - Lozoff, Betsy AU - Breilh, Jaime AU - Harlow, Siobán D AD - Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA. handalal@mail.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 312 EP - 320 VL - 18 IS - 3 SN - 1044-3983, 1044-3983 KW - Pesticides KW - 0 KW - Water Pollutants, Chemical KW - Water KW - 059QF0KO0R KW - Index Medicus KW - Agriculture KW - Flowers KW - Humans KW - Ecuador -- epidemiology KW - Child, Preschool KW - Socioeconomic Factors KW - Motor Skills -- drug effects KW - Risk Factors KW - Neuropsychological Tests KW - Residence Characteristics KW - Problem Solving -- drug effects KW - Female KW - Male KW - Water Pollutants, Chemical -- adverse effects KW - Child Development -- drug effects KW - Environmental Exposure -- adverse effects KW - Pesticides -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70386366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+%28Cambridge%2C+Mass.%29&rft.atitle=Neurobehavioral+development+in+children+with+potential+exposure+to+pesticides.&rft.au=Handal%2C+Alexis+J%3BLozoff%2C+Betsy%3BBreilh%2C+Jaime%3BHarlow%2C+Siob%C3%A1n+D&rft.aulast=Handal&rft.aufirst=Alexis&rft.date=2007-05-01&rft.volume=18&rft.issue=3&rft.spage=312&rft.isbn=&rft.btitle=&rft.title=Epidemiology+%28Cambridge%2C+Mass.%29&rft.issn=10443983&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-16 N1 - Date created - 2007-04-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Determination of the ex vivo rates of human immunodeficiency virus type 1 reverse transcription by using novel strand-specific amplification analysis. AN - 70380858; 17314159 AB - Replication of human immunodeficiency virus type 1 (HIV-1), like all organisms, involves synthesis of a minus-strand and a plus-strand of nucleic acid. Currently available PCR methods cannot distinguish between the two strands of nucleic acids. To carry out detailed analysis of HIV-1 reverse transcription from infected cells, we have developed a novel strand-specific amplification (SSA) assay using single-stranded padlock probes that are specifically hybridized to a target strand, ligated, and quantified for sensitive analysis of the kinetics of HIV-1 reverse transcription in cells. Using SSA, we have determined for the first time the ex vivo rates of HIV-1 minus-strand DNA synthesis in 293T and human primary CD4(+) T cells ( approximately 68 to 70 nucleotides/min). We also determined the rates of minus-strand DNA transfer ( approximately 4 min), plus-strand DNA transfer ( approximately 26 min), and initiation of plus-strand DNA synthesis ( approximately 9 min) in 293T cells. Additionally, our results indicate that plus-strand DNA synthesis is initiated at multiple sites and that several reverse transcriptase inhibitors influence the kinetics of minus-strand DNA synthesis differently, providing insights into their mechanism of inhibition. The SSA technology provides a novel approach to analyzing DNA replication processes and should facilitate the development of new antiretroviral drugs that target specific steps in HIV-1 reverse transcription. JF - Journal of virology AU - Thomas, David C AU - Voronin, Yegor A AU - Nikolenko, Galina N AU - Chen, Jianbo AU - Hu, Wei-Shau AU - Pathak, Vinay K AD - Viral Mutation Section, HIV Drug Resistance Program, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702, USA. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 4798 EP - 4807 VL - 81 IS - 9 SN - 0022-538X, 0022-538X KW - DNA Probes KW - 0 KW - DNA, Single-Stranded KW - Oligonucleotides KW - Index Medicus KW - DNA Probes -- genetics KW - Base Sequence KW - Kinetics KW - Humans KW - Molecular Sequence Data KW - CD4-Positive T-Lymphocytes -- physiology KW - Cell Line KW - Mutagenesis KW - Virus Replication KW - Reverse Transcription -- physiology KW - Nucleic Acid Amplification Techniques -- methods KW - DNA, Single-Stranded -- physiology KW - HIV-1 -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70380858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Determination+of+the+ex+vivo+rates+of+human+immunodeficiency+virus+type+1+reverse+transcription+by+using+novel+strand-specific+amplification+analysis.&rft.au=Thomas%2C+David+C%3BVoronin%2C+Yegor+A%3BNikolenko%2C+Galina+N%3BChen%2C+Jianbo%3BHu%2C+Wei-Shau%3BPathak%2C+Vinay+K&rft.aulast=Thomas&rft.aufirst=David&rft.date=2007-05-01&rft.volume=81&rft.issue=9&rft.spage=4798&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-26 N1 - Date created - 2007-04-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arch Pathol Lab Med. 1999 Dec;123(12):1170-6 [10583921] Nat Genet. 1998 Jul;19(3):225-32 [9662393] Cell. 2000 Apr 14;101(2):173-85 [10786833] J Virol. 2000 Nov;74(21):10074-80 [11024136] Blood. 2000 Dec 15;96(13):4103-10 [11110680] Nat Med. 2001 May;7(5):631-4 [11329067] AIDS Res Hum Retroviruses. 2001 Jun 10;17(9):799-805 [11429121] J Clin Microbiol. 2003 Oct;41(10):4531-6 [14532178] AIDS Res Hum Retroviruses. 2003 Oct;19(10):865-74 [14585218] J Virol. 2004 May;78(10):5402-13 [15113919] Biochemistry. 1976 Aug 10;15(16):3605-11 [60129] J Virol. 1977 Jan;21(1):168-78 [64624] J Mol Biol. 1978 Mar 25;120(1):55-82 [205652] J Virol. 1981 Jan;37(1):109-16 [6260966] J Biol Chem. 1988 Oct 25;263(30):15657-65 [2459125] J Biol Chem. 1989 Mar 15;264(8):4669-78 [2466838] Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7276-80 [1871133] J Biol Chem. 1992 Dec 25;267(36):25988-97 [1281479] Genomics. 1993 Jan;15(1):21-9 [7916736] J Biol Chem. 1993 Apr 25;268(12):8743-51 [7682554] J Virol. 1994 Feb;68(2):1258-63 [7507180] Science. 1994 Sep 30;265(5181):2085-8 [7522346] Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9564-8 [7937806] J Virol. 1995 Jun;69(6):3938-44 [7745750] J Gen Virol. 1995 Jul;76 ( Pt 7):1675-86 [9049373] J Virol. 1997 Dec;71(12):9259-69 [9371584] J Exp Med. 1999 Jun 7;189(11):1735-46 [10359577] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Functional characterization of human bitter taste receptors. AN - 70378522; 17253962 AB - The T2Rs belong to a multi-gene family of G-protein-coupled receptors responsible for the detection of ingested bitter-tasting compounds. The T2Rs are conserved among mammals with the human and mouse gene families consisting of about 25 members. In the present study we address the signalling properties of human and mouse T2Rs using an in vitro reconstitution system in which both the ligands and G-proteins being assayed can be manipulated independently and quantitatively assessed. We confirm that the mT2R5, hT2R43 and hT2R47 receptors respond selectively to micromolar concentrations of cycloheximide, aristolochic acid and denatonium respectively. We also demonstrate that hT2R14 is a receptor for aristolochic acid and report the first characterization of the ligand specificities of hT2R7, which is a broadly tuned receptor responding to strychnine, quinacrine, chloroquine and papaverine. Using these defined ligand-receptor interactions, we assayed the ability of the ligand-activated T2Rs to catalyse GTP binding on divergent members of the G(alpha) family including three members of the G(alphai) subfamily (transducin, G(alphai1) and G(alphao)) as well as G(alphas) and G(alphaq). The T2Rs coupled with each of the three G(alphai) members tested. However, none of the T2Rs coupled to either G(alphas) or G(alphaq), suggesting the T2Rs signal primarily through G(alphai)-mediated signal transduction pathways. Furthermore, we observed different G-protein selectivities among the T2Rs with respect to both G(alphai) subunits and G(betagamma) dimers, suggesting that bitter taste is transduced by multiple G-proteins that may differ among the T2Rs. JF - The Biochemical journal AU - Sainz, Eduardo AU - Cavenagh, Margaret M AU - Gutierrez, Joanne AU - Battey, James F AU - Northup, John K AU - Sullivan, Susan L AD - Section on G-protein Coupled Receptors, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. Y1 - 2007/05/01/ PY - 2007 DA - 2007 May 01 SP - 537 EP - 543 VL - 403 IS - 3 KW - Aristolochic Acids KW - 0 KW - Quaternary Ammonium Compounds KW - Receptors, G-Protein-Coupled KW - Recombinant Fusion Proteins KW - taste receptors, type 2 KW - aristolochic acid I KW - 94218WFP5T KW - Cycloheximide KW - 98600C0908 KW - Transducin KW - EC 3.6.5.1 KW - Index Medicus KW - Recombinant Fusion Proteins -- metabolism KW - Quaternary Ammonium Compounds -- metabolism KW - Animals KW - Aristolochic Acids -- metabolism KW - Cycloheximide -- metabolism KW - Humans KW - Mice KW - Signal Transduction KW - Transducin -- metabolism KW - Taste -- physiology KW - Receptors, G-Protein-Coupled -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70378522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Biochemical+journal&rft.atitle=Functional+characterization+of+human+bitter+taste+receptors.&rft.au=Sainz%2C+Eduardo%3BCavenagh%2C+Margaret+M%3BGutierrez%2C+Joanne%3BBattey%2C+James+F%3BNorthup%2C+John+K%3BSullivan%2C+Susan+L&rft.aulast=Sainz&rft.aufirst=Eduardo&rft.date=2007-05-01&rft.volume=403&rft.issue=3&rft.spage=537&rft.isbn=&rft.btitle=&rft.title=The+Biochemical+journal&rft.issn=1470-8728&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-07 N1 - Date created - 2007-04-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Pharmacol. 1999 Dec;56(6):1362-9 [10570066] Biochem J. 1995 Jul 15;309 ( Pt 2):629-36 [7626029] Cell. 2000 Mar 17;100(6):693-702 [10761934] Cell. 2000 Mar 17;100(6):703-11 [10761935] Nature. 2000 Apr 6;404(6778):601-4 [10766242] Nature. 1996 Jun 27;381(6585):796-800 [8657284] J Biol Chem. 1996 Sep 13;271(37):22591-7 [8798428] Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):751-6 [9012857] Eur J Cell Biol. 1998 Nov;77(3):253-61 [9860142] Cell. 1998 Dec 23;95(7):917-26 [9875846] J Biol Chem. 1999 Apr 23;274(17):11573-81 [10206964] Biotechniques. 1999 Jun;26(6):1082-6 [10376146] J Neurosci. 2004 Nov 10;24(45):10260-5 [15537898] Curr Biol. 2005 Feb 22;15(4):322-7 [15723792] J Biol Chem. 2006 May 12;281(19):13103-9 [16551618] Chem Senses. 2000 Aug;25(4):413-21 [10944505] Am J Physiol Cell Physiol. 2001 Apr;280(4):C742-51 [11245589] Nature. 2001 Sep 13;413(6852):219-25 [11557991] Chem Senses. 2002 Oct;27(8):719-27 [12379596] Nat Genet. 2002 Nov;32(3):397-401 [12379855] Cell. 2003 Feb 7;112(3):293-301 [12581520] Cytogenet Genome Res. 2002;98(1):45-53 [12584440] Mol Biol Evol. 2003 May;20(5):805-14 [12679530] Physiol Genomics. 2003 Jun 24;14(1):73-82 [12734386] J Neurosci. 2003 Oct 29;23(30):9947-52 [14586025] Mol Psychiatry. 2004 Jan;9(1):55-64 [14699441] Eur J Pharmacol. 2004 Apr 12;489(3):139-49 [15087236] Biochem Biophys Res Commun. 2004 Jun 25;319(2):479-85 [15178431] Chem Senses. 2004 Sep;29(7):583-93 [15337684] Biochemistry. 1974 May 21;13(11):2438-44 [4545509] Nature. 1980 Feb 7;283(5747):587-9 [6101903] Methods Enzymol. 1988;159:702-10 [2842631] Methods Enzymol. 1991;195:192-202 [1903486] J Biol Chem. 1991 Jul 5;266(19):12194-200 [1905716] Nature. 1992 Jun 18;357(6379):563-9 [1608467] Methods Enzymol. 1994;237:254-68 [7935001] Nat Neurosci. 1999 Dec;2(12):1055-62 [10570481] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comprehensive evaluation of allele frequency differences of MC1R variants across populations. AN - 70350323; 17279550 AB - The melanocortin 1 receptor (MC1R), a member of the G protein-coupled receptors superfamily, mediates the response to melanocortins and is currently the best-described contributor to normal pigment variation in humans. A remarkably large number of natural polymorphisms, or variants, of the MC1R gene have been identified in different populations. Some of these variants have been associated with specific hair and skin color phenotypes, the presence of freckling, and melanoma and nonmelanoma skin cancer risk. Interestingly, some MC1R variants have been associated with skin cancer beyond their effects on pigmentation. Although the red hair color variants (RHC variants) have been associated with skin cancer risk in the Celtic population, studies in darkly-pigmented Caucasian populations have demonstrated the importance of non-RHC MC1R variants on skin cancer risk as well. We have reviewed and compared allele frequency differences of MC1R variants across geographic regions. We observed large differences in the distribution of variants across populations, with a prominent difference between lightly and darkly-pigmented individuals. Moreover, among Caucasian groups, there were seven variants (p.V60L, p.V92M, p.D84E, p.R151C, p.R160W, p.R163Q, and p.D294H) with significantly different allele frequencies. Exploring differences in allele frequencies of MC1R variants across populations with varying pigmentation and differing skin cancer risk may improve our understanding of the complex relationship between MC1R, pigmentation, and carcinogenesis. 2007 Wiley-Liss, Inc. JF - Human mutation AU - Gerstenblith, Meg R AU - Goldstein, Alisa M AU - Fargnoli, Maria Concetta AU - Peris, Ketty AU - Landi, Maria Teresa AD - Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-7236, USA. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 495 EP - 505 VL - 28 IS - 5 KW - Receptor, Melanocortin, Type 1 KW - 0 KW - Index Medicus KW - Skin Neoplasms -- genetics KW - Humans KW - Alleles KW - Genetics, Population KW - Gene Frequency KW - Receptor, Melanocortin, Type 1 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70350323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+mutation&rft.atitle=Comprehensive+evaluation+of+allele+frequency+differences+of+MC1R+variants+across+populations.&rft.au=Gerstenblith%2C+Meg+R%3BGoldstein%2C+Alisa+M%3BFargnoli%2C+Maria+Concetta%3BPeris%2C+Ketty%3BLandi%2C+Maria+Teresa&rft.aulast=Gerstenblith&rft.aufirst=Meg&rft.date=2007-05-01&rft.volume=28&rft.issue=5&rft.spage=495&rft.isbn=&rft.btitle=&rft.title=Human+mutation&rft.issn=1098-1004&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-21 N1 - Date created - 2007-04-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Carcinogenesis studies of benzophenone in rats and mice. AN - 70310649; 17187913 AB - Benzophenone, an aryl ketone, is used primarily as a photoinitiator and fragrance enhancer. Groups of 50 male and 50 female F344 rats and B6C3 F1 mice were fed diets containing 0, 312, 625, and 1250 ppm benzophenone for 105 weeks. Survival of males exposed to 1250 ppm benzophenone was significantly less than that of controls. There was a positive trend in the incidence of renal tubule adenoma in male rats; these neoplasms were accompanied by significantly increased incidences of renal tubule hyperplasia. Increased incidences of mononuclear cell leukemia were observed in male rats exposed to 312 or 625 ppm benzophenone and in female rats exposed to 625 ppm benzophenone. Liver lesions observed included significantly increased incidences of hepatocytic centrilobular hypertrophy in all exposed groups of rats. In mice, survival of all exposed groups was generally similar to that of the control groups. In male mice, there were significantly increased incidences of hepatocellular adenoma in the 625 and 1250 ppm groups. In female mice, the incidences of hepatocellular adenoma in the 625 and 1250 ppm groups were higher than expected after adjusting for the lower body weights in these groups. The incidences of kidney nephropathy in exposed groups of female mice, as well as the severity of nephropathy in exposed groups of males, were significantly increased. The incidences of metaplasia of the olfactory epithelium were significantly increased in 1250 ppm mice. Rare histiocytic sarcomas were observed in female rats and mice in the 625 and 1250 ppm groups. Under the conditions of these 2-year studies, there was some evidence of carcinogenic activity of benzophenone in male F344/N rats based on increased incidences of renal tubule adenoma. There was equivocal evidence of carcinogenic activity of benzophenone in female F344/N rats based on the marginal increased incidences of mononuclear cell leukemia and histiocytic sarcoma. There was some evidence of carcinogenic activity of benzophenone in male B6C3F(1) mice based on increased incidences of hepatocellular neoplasms, primarily adenoma. There was some evidence of carcinogenic activity of benzophenone in female B6C3F(1) mice based on increased incidences of histiocytic sarcoma; the incidences of hepatocellular adenoma in female B6C3F(1) mice may have been related to benzophenone exposure. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Rhodes, M C AU - Bucher, J R AU - Peckham, J C AU - Kissling, G E AU - Hejtmancik, M R AU - Chhabra, R S AD - National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, United States. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 843 EP - 851 VL - 45 IS - 5 SN - 0278-6915, 0278-6915 KW - Benzophenones KW - 0 KW - Photosensitizing Agents KW - benzophenone KW - 701M4TTV9O KW - Index Medicus KW - Animals KW - Kidney Neoplasms -- pathology KW - Leukemia -- chemically induced KW - Sex Factors KW - Dose-Response Relationship, Drug KW - Kidney Neoplasms -- chemically induced KW - Liver Neoplasms -- chemically induced KW - Mice KW - Histiocytic Disorders, Malignant -- pathology KW - Sarcoma -- chemically induced KW - Histiocytic Disorders, Malignant -- chemically induced KW - Rats KW - Leukemia -- pathology KW - Mice, Inbred Strains KW - Rats, Inbred F344 KW - Liver Neoplasms -- pathology KW - Adenoma -- chemically induced KW - Adenoma -- pathology KW - Sarcoma -- pathology KW - Male KW - Female KW - Photosensitizing Agents -- toxicity KW - Neoplasms, Experimental -- chemically induced KW - Benzophenones -- toxicity KW - Carcinogenicity Tests -- methods KW - Neoplasms, Experimental -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70310649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Carcinogenesis+studies+of+benzophenone+in+rats+and+mice.&rft.au=Rhodes%2C+M+C%3BBucher%2C+J+R%3BPeckham%2C+J+C%3BKissling%2C+G+E%3BHejtmancik%2C+M+R%3BChhabra%2C+R+S&rft.aulast=Rhodes&rft.aufirst=M&rft.date=2007-05-01&rft.volume=45&rft.issue=5&rft.spage=843&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=02786915&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-22 N1 - Date created - 2007-03-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Am Acad Dermatol. 2003 Nov;49(5 Suppl):S259-61 [14576646] Toxic Rep Ser. 2000 Apr;(61):1-53, A1-13 [11803700] Biometrics. 1971 Mar;27(1):103-17 [5547548] Biometrics. 1972 Jun;28(2):519-31 [5037867] Biometrics. 1988 Jun;44(2):417-31 [3390507] Fundam Appl Toxicol. 1989 May;12(4):731-7 [2744275] Ren Fail. 1991;13(4):211-25 [1780490] Toxicol Pathol. 1993;21(2):206-18 [8210943] Environ Health Perspect. 1993 Dec;101 Suppl 5:115-20 [7516872] Toxicol Pathol. 1994 Sep-Oct;22(5):457-72 [7899775] Toxicol Pathol. 1997 May-Jun;25(3):256-63 [9210256] Toxicol Pathol. 1999 Jul-Aug;27(4):383-94 [10485818] Toxicol Pathol. 1998 Jan-Feb;26(1):104-12 [9502392] Contact Dermatitis. 2001 Mar;44(3):188 [11217999] Toxicol Pathol. 2002 Nov-Dec;30(6):681-6 [12512869] Australas J Dermatol. 2001 Nov;42(4):257-9 [11903157] Bioorg Med Chem. 2004 May 15;12(10):2759-72 [15110857] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - R115777 (Zarnestra)/Zoledronic acid (Zometa) cooperation on inhibition of prostate cancer proliferation is paralleled by Erk/Akt inactivation and reduced Bcl-2 and bad phosphorylation. AN - 70226361; 17192846 AB - Zoledronic acid (ZOL) has proved activity in bone metastases from prostate cancer through inhibition of mevalonate pathway and of prenylation of intracellular proteins. We have reported that ZOL synergizes with R115777 farnesyltransferase inhibitor (FTI, Zarnestra) in inducing apoptosis and growth inhibition on epidermoid cancer cells. Here, we have studied the effects of the combination of these agents in prostate adenocarcinoma models and, specifically, on androgen-independent (PC3 and DU145) and -dependent (LNCaP) prostate cancer cell lines. We have found that ZOL and R115777 were synergistic in inducing both growth inhibition and apoptosis in prostate adenocarcinoma cells. These effects were paralleled by disruption of Ras-->Erk and Akt survival pathways, consequent decreased phosphorylation of both mitochondrial bcl-2 and bad proteins, and caspase activation. Finally, ZOL/R115777 combination induced cooperative effects also in vivo on tumor growth inhibition of prostate cancer xenografts in nude mice with a significant survival increase. These effects were paralleled by enhanced apoptosis and inactivation of both Erk and Akt. In conclusions, the combination between ZOL and FTI leads to enhanced anti-tumor activity in human prostate adenocarcinoma cells likely through a more efficacious inhibition of ras-dependent survival pathways and consequent bcl-related proteins-dependent apoptosis. (c) 2007 Wiley-Liss, Inc. JF - Journal of cellular physiology AU - Caraglia, Michele AU - Marra, Monica AU - Leonetti, Carlo AU - Meo, Giuseppina AU - D'Alessandro, Anna Maria AU - Baldi, Alfonso AU - Santini, Daniele AU - Tonini, Giuseppe AU - Bertieri, Raffaello AU - Zupi, Gabriella AU - Budillon, Alfredo AU - Abbruzzese, Alberto AD - Experimental Pharmacology Unit, National Cancer Institute of Naples "Fondazione G. Pascale," Naples, Italy. Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 533 EP - 543 VL - 211 IS - 2 SN - 0021-9541, 0021-9541 KW - Antineoplastic Agents KW - 0 KW - Apoptosis Regulatory Proteins KW - BAD protein, human KW - Diphosphonates KW - Imidazoles KW - Proto-Oncogene Proteins c-bcl-2 KW - Quinolones KW - bcl-Associated Death Protein KW - zoledronic acid KW - 6XC1PAD3KF KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Extracellular Signal-Regulated MAP Kinases KW - EC 2.7.11.24 KW - Caspases KW - EC 3.4.22.- KW - ras Proteins KW - EC 3.6.5.2 KW - tipifarnib KW - MAT637500A KW - Index Medicus KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Mice, Nude KW - Cell Line, Tumor KW - Mice KW - Extracellular Signal-Regulated MAP Kinases -- metabolism KW - Mice, Inbred BALB C KW - Caspases -- metabolism KW - bcl-Associated Death Protein -- metabolism KW - Phosphorylation -- drug effects KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Apoptosis -- drug effects KW - Enzyme Activation -- drug effects KW - Xenograft Model Antitumor Assays KW - ras Proteins -- metabolism KW - Drug Synergism KW - Time Factors KW - Male KW - Prostatic Neoplasms -- metabolism KW - Cell Proliferation -- drug effects KW - Adenocarcinoma -- metabolism KW - Diphosphonates -- therapeutic use KW - Imidazoles -- pharmacology KW - Quinolones -- therapeutic use KW - Prostatic Neoplasms -- drug therapy KW - Adenocarcinoma -- pathology KW - Diphosphonates -- pharmacology KW - Prostatic Neoplasms -- pathology KW - Signal Transduction -- drug effects KW - Apoptosis Regulatory Proteins -- metabolism KW - Imidazoles -- therapeutic use KW - Adenocarcinoma -- drug therapy KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacology KW - Quinolones -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70226361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+physiology&rft.atitle=R115777+%28Zarnestra%29%2FZoledronic+acid+%28Zometa%29+cooperation+on+inhibition+of+prostate+cancer+proliferation+is+paralleled+by+Erk%2FAkt+inactivation+and+reduced+Bcl-2+and+bad+phosphorylation.&rft.au=Caraglia%2C+Michele%3BMarra%2C+Monica%3BLeonetti%2C+Carlo%3BMeo%2C+Giuseppina%3BD%27Alessandro%2C+Anna+Maria%3BBaldi%2C+Alfonso%3BSantini%2C+Daniele%3BTonini%2C+Giuseppe%3BBertieri%2C+Raffaello%3BZupi%2C+Gabriella%3BBudillon%2C+Alfredo%3BAbbruzzese%2C+Alberto&rft.aulast=Caraglia&rft.aufirst=Michele&rft.date=2007-05-01&rft.volume=211&rft.issue=2&rft.spage=533&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+physiology&rft.issn=00219541&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-15 N1 - Date created - 2007-03-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Adult minimal-change disease: clinical characteristics, treatment, and outcomes. AN - 68168377; 17699450 AB - Minimal-change disease (MCD) counts for 10 to 15% of cases of primary nephrotic syndrome in adults. Few series have examined this disease in adults. A retrospective review was performed of 95 adults who had MCD and were seen at a single referral center. Examined were presenting features, response to daily versus alternate-day steroids, response to second-line agents, relapse patterns, complications of the disease and therapy, presence of acute renal failure (ARF), and outcome data. Sixty-five patients received daily and 23 received alternate-day steroids initially. There were no differences in remissions, time to remission, relapse rate, or time to relapse between daily- and alternate-day-treated patients. More than one quarter of patients were steroid resistant. At least one relapse occurred in 73% of patients; 28% were frequently relapsing. A significant proportion of frequently relapsing patients became steroid dependent. Second-line agents were used for steroid dependence, steroid resistance, or frequent relapses. No single agent proved superior. There were more remissions with second-line agents in steroid-dependent patients compared with steroid-resistant patients, and remissions were more likely to be complete in steroid-dependent patients. ARF occurred in 24 patients; they tended to be older and hypertensive with lower serum albumin and more proteinuria than those without ARF. At follow up, patients with an episode of ARF had higher serum creatinine than those without ARF. Four patients progressed to ESRD. These patients were less likely to have responded to steroids and more likely to have FSGS on repeat renal biopsy. In this referral MCD population, response to daily and alternate-day steroids is similar. Second-line agents give greater response in patients who are steroid dependent. ARF occurs in a significant number of adult MCD patients and may leave residual renal dysfunction. Few patients progress to ESRD. JF - Clinical journal of the American Society of Nephrology : CJASN AU - Waldman, Meryl AU - Crew, R John AU - Valeri, Anthony AU - Busch, Joshua AU - Stokes, Barry AU - Markowitz, Glen AU - D'Agati, Vivette AU - Appel, Gerald AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. waldmanm@niddk.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 445 EP - 453 VL - 2 IS - 3 KW - Immunosuppressive Agents KW - 0 KW - Steroids KW - Cyclosporine KW - 83HN0GTJ6D KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - Steroids -- therapeutic use KW - Drug Administration Schedule KW - Cyclosporine -- therapeutic use KW - Humans KW - Retrospective Studies KW - Steroids -- administration & dosage KW - Acute Kidney Injury -- etiology KW - Aged KW - Drug Resistance KW - Kidney Failure, Chronic -- etiology KW - Recurrence KW - Cyclophosphamide -- therapeutic use KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Follow-Up Studies KW - Immunosuppressive Agents -- therapeutic use KW - Male KW - Female KW - Nephrosis, Lipoid -- complications KW - Nephrosis, Lipoid -- drug therapy KW - Nephrosis, Lipoid -- blood KW - Nephrosis, Lipoid -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68168377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+journal+of+the+American+Society+of+Nephrology+%3A+CJASN&rft.atitle=Adult+minimal-change+disease%3A+clinical+characteristics%2C+treatment%2C+and+outcomes.&rft.au=Waldman%2C+Meryl%3BCrew%2C+R+John%3BValeri%2C+Anthony%3BBusch%2C+Joshua%3BStokes%2C+Barry%3BMarkowitz%2C+Glen%3BD%27Agati%2C+Vivette%3BAppel%2C+Gerald&rft.aulast=Waldman&rft.aufirst=Meryl&rft.date=2007-05-01&rft.volume=2&rft.issue=3&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=Clinical+journal+of+the+American+Society+of+Nephrology+%3A+CJASN&rft.issn=1555-905X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-28 N1 - Date created - 2007-08-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Parental Practices and Willingness to Ask for Children's Help Later in Life AN - 57233613; 200812641 AB - We examine how parents' relationships with their 13- to 25-year-old offspring affect the parents' willingness to ask them for help with financial and personal problems 20 years later. Husbands and wives were interviewed in 1974 and 1994; a child was interviewed in 1974. We used two aspects of parental style, responsiveness and restrictive dominance, to predict parents' willingness to request help from a child 20 years later. Structural equation modeling analyses revealed the following: (a) mothers' willingness to ask an adult child for help with a personal problem was increased by higher levels of responsiveness; (b) mothers' willingness to ask for financial help was increased by responsive and decreased by restrictive-dominant maternal behavior; and (c) neither responsive nor restrictive-dominant paternal behavior affected fathers' later willingness to ask an adult child for help of either kind. Adapted from the source document. JF - Journals of Gerontology Series B: Psychological Sciences and Social Sciences AU - Schooler, Carmi AU - Revell, Andrew J AU - Caplan, Leslie J AD - National Institute of Mental Health, National Institutes of Health, 6101 Executive Boulevard, Suite 360, Room 362, MSC 8408, Bethesda, MD 20892-8408 E-mail: carmi.schooler@nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - P165 EP - P170 PB - Gerontological Society of America, Washington DC VL - 62B IS - 3 SN - 1079-5014, 1079-5014 KW - Parenting style KW - Parent-Child relationships KW - Parents KW - Helpseeking KW - Parent-Adult child relationships KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57233613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journals+of+Gerontology+Series+B%3A+Psychological+Sciences+and+Social+Sciences&rft.atitle=Parental+Practices+and+Willingness+to+Ask+for+Children%27s+Help+Later+in+Life&rft.au=Schooler%2C+Carmi%3BRevell%2C+Andrew+J%3BCaplan%2C+Leslie+J&rft.aulast=Schooler&rft.aufirst=Carmi&rft.date=2007-05-01&rft.volume=62B&rft.issue=3&rft.spage=P165&rft.isbn=&rft.btitle=&rft.title=Journals+of+Gerontology+Series+B%3A+Psychological+Sciences+and+Social+Sciences&rft.issn=10795014&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-11 N1 - Last updated - 2016-09-27 N1 - CODEN - JGBSF3 N1 - SubjectsTermNotLitGenreText - Parent-Child relationships; Parent-Adult child relationships; Helpseeking; Parents; Parenting style ER - TY - JOUR T1 - Hurricane Readiness and Environmental Risks on the Bayous -- An NIEHS Community-Based Pilot Project in South Terrebonne-Lafourche Parishes, Louisiana AN - 57097193; 200801162 AB - Describes a National Instit of Environmental Health Sciences cite-specific community environmental risk curriculum focused on health consequences of hurricanes with an eye toward improved disaster preparedness. Major areas of concern based on survey responses are listed, along with the training program's major topics. Adapted from the source document. JF - Journal of Health Care for the Poor and Underserved AU - Sullivan, John AD - Sealy Center Environmental Health & Medicine/NIEHS Center Environmental Toxicology, U Texas Medical Branch, Galveston josulliv@utmb.edu Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 487 EP - 491 PB - John Hopkins University Press, Baltimore MD VL - 18 IS - 2 SN - 1049-2089, 1049-2089 KW - Hurricanes KW - Training KW - Curriculum KW - Disaster management KW - Environmental health KW - Risks KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57097193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.atitle=Hurricane+Readiness+and+Environmental+Risks+on+the+Bayous+--+An+NIEHS+Community-Based+Pilot+Project+in+South+Terrebonne-Lafourche+Parishes%2C+Louisiana&rft.au=Sullivan%2C+John&rft.aulast=Sullivan&rft.aufirst=John&rft.date=2007-05-01&rft.volume=18&rft.issue=2&rft.spage=487&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.issn=10492089&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-01-04 N1 - Last updated - 2016-09-27 N1 - CODEN - JHCUEK N1 - SubjectsTermNotLitGenreText - Risks; Curriculum; Disaster management; Hurricanes; Training; Environmental health ER - TY - JOUR T1 - Perceived helpfulness and impact of social support provided by family, friends, and health care providers to women newly diagnosed with breast cancer AN - 57092934; 200800041 AB - We evaluated the helpfulness of informational, emotional, and decision-making support received by women newly diagnosed with breast cancer from their family, friends, and health care providers. Data were collected at two time points via patient surveys: baseline on an average 2 months post-diagnosis and follow-up at 5 months post-baseline. In the period closer to diagnosis, majority of the women received helpful informational support from health care providers (84.0%); helpful emotional support from family (85%), friends (80.4%), and providers (67.1%); and helpful decision-making support from providers (75.2%) and family (71.0%). Emotional support at baseline and emotional and informational support at 5-month follow-up were significantly associated with patients' health-related quality of life and self-efficacy outcomes (p < 0.01). Perceived helpfulness of informational, emotional, and decision-making support provided by family, friends, and providers however significantly decreased over time (p< 0.001). Cancer patients desire significant amount of support throughout their cancer journey. Our results show that while patients receive a lot of support during the period closer to diagnosis, receipt of helpful support drops significantly within the first year itself. In order to facilitate cancer patients' adjustment to their illness, efforts need to be made to understand and address their support needs throughout the cancer experience. [Copyright 2006 John Wiley and Sons, Ltd.] JF - Psycho-Oncology AU - Arora, Neeraj K AU - Rutten, Lila J. Finney AU - Gustafson, David H AU - Moser, Richard AU - Hawkins, Robert P AD - Outcomes Research Branch, Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute 6130 Executive Blvd, MSC 7344, Executive Plaza North #4005 Bethesda, MD 20892-7344, USA aroran@mail.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 474 EP - 486 PB - John Wiley, Chichester UK VL - 16 IS - 5 SN - 1057-9249, 1057-9249 KW - social support, breast cancer, health-related quality of life, coping, self regulation, longitudinal analysis KW - Selfefficacy KW - Helpfulness KW - Newly diagnosed KW - Social support KW - Breast cancer KW - Quality of life KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57092934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psycho-Oncology&rft.atitle=Perceived+helpfulness+and+impact+of+social+support+provided+by+family%2C+friends%2C+and+health+care+providers+to+women+newly+diagnosed+with+breast+cancer&rft.au=Arora%2C+Neeraj+K%3BRutten%2C+Lila+J.+Finney%3BGustafson%2C+David+H%3BMoser%2C+Richard%3BHawkins%2C+Robert+P&rft.aulast=Arora&rft.aufirst=Neeraj&rft.date=2007-05-01&rft.volume=16&rft.issue=5&rft.spage=474&rft.isbn=&rft.btitle=&rft.title=Psycho-Oncology&rft.issn=10579249&rft_id=info:doi/10.1002%2Fpon.1084 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-01-04 N1 - Last updated - 2016-09-27 N1 - CODEN - POJCEE N1 - SubjectsTermNotLitGenreText - Newly diagnosed; Breast cancer; Quality of life; Helpfulness; Social support; Selfefficacy DO - http://dx.doi.org/10.1002/pon.1084 ER - TY - JOUR T1 - Memory Illusion in High-Functioning Autism and Asperger's Disorder AN - 57076700; 200720838 AB - In this study, 13 individuals with high-functioning autism (HFA), 15 individuals with Asperger's disorder (AD), and age-, and IQ-matched controls were presented a list of sentences auditorily. Participants then evaluated semantically related but new sentences and reported whether they were old or new. The total rates of false recognition for semantically related sentences were similar among the three groups. Nevertheless, memory illusion on some aspects was reduced in HFA participants. These results suggest that HFA have difficulties in semantic association. Although individuals with AD showed no quantitative abnormalities of memory illusion, some contributing factors were atypical. These findings are discussed in terms of schema theory, enhanced perceptual processing hypothesis, and weak central coherence hypothesis. Adapted from the source document. JF - Journal of Autism and Developmental Disorders AU - Kamio, Yoko AU - Toichi, Motomi AD - Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi-cho, Kodaira, 187-8551 Tokyo, Japan kamio@ncnp.go.jp Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 867 EP - 876 PB - Springer, Dordrecht The Netherlands VL - 37 IS - 5 SN - 0162-3257, 0162-3257 KW - High functioning KW - Semantic association KW - Aspergers syndrome KW - Autism KW - Memory tests KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57076700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Memory+Illusion+in+High-Functioning+Autism+and+Asperger%27s+Disorder&rft.au=Kamio%2C+Yoko%3BToichi%2C+Motomi&rft.aulast=Kamio&rft.aufirst=Yoko&rft.date=2007-05-01&rft.volume=37&rft.issue=5&rft.spage=867&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/10.1007%2Fs10803-006-0214-y LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-12-10 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDDQ N1 - SubjectsTermNotLitGenreText - Aspergers syndrome; Autism; High functioning; Memory tests; Semantic association DO - http://dx.doi.org/10.1007/s10803-006-0214-y ER - TY - JOUR T1 - An RNA-making reactor for the origin of life; discussion AN - 50117861; 2010-004109 JF - Proceedings of the National Academy of Sciences of the United States of America AU - Koonin, Eugene V Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 9105 EP - 9106 PB - National Academy of Sciences, Washington, DC VL - 104 IS - 22 SN - 0027-8424, 0027-8424 KW - RNA KW - chemical reactions KW - biochemistry KW - hydrothermal vents KW - biologic evolution KW - ocean floors KW - life origin KW - 08:General paleontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50117861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=An+RNA-making+reactor+for+the+origin+of+life%3B+discussion&rft.au=Koonin%2C+Eugene+V&rft.aulast=Koonin&rft.aufirst=Eugene&rft.date=2007-05-01&rft.volume=104&rft.issue=22&rft.spage=9105&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/10.1073%2Fpnas.0702699104 L2 - http://www.pnas.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2010-01-01 N1 - Number of references - 19 N1 - PubXState - DC N1 - Document feature - illus. N1 - SuppNotes - For reference to original see Baaske, P., et. al., Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 22, p. 9346-9351, 2007 N1 - Last updated - 2012-06-07 N1 - CODEN - PNASA6 N1 - SubjectsTermNotLitGenreText - biochemistry; biologic evolution; chemical reactions; hydrothermal vents; life origin; ocean floors; RNA DO - http://dx.doi.org/10.1073/pnas.0702699104 ER - TY - JOUR T1 - MRI of mouse models of neurological disorders AN - 21067176; 8632217 AB - MRI has contributed to significant advances in the understanding of neurological diseases in humans. It has also been used to evaluate the spectrum of mouse models spanning from developmental abnormalities during embryogenesis, evaluation of transgenic and knockout models, through various neurological diseases such as stroke, tumors, degenerative and inflammatory diseases. The MRI techniques used clinically are technically more challenging in the mouse because of the size of the brain; however, mouse imaging provides researchers with the ability to explore cellular and molecular imaging that one day may translate into clinical practice. This article presents an overview of the use of MRI in mouse models of a variety of neurological disorders and a brief review of cellular imaging using magnetically tagged cells in the mouse central nervous system. Published in 2007 by John Wiley & Sons, Ltd. JF - NMR in Biomedicine AU - Anderson, Stasia A AU - Frank, Joseph A AD - Animal MRI/Imaging Core, National Heart Lung and Blood Institute, NIH, Bethesda, MD, USA,; sanderso@helix.nih.gov] andersos1@nhlbi.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 200 EP - 215 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 20 IS - 3 SN - 0952-3480, 0952-3480 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Central nervous system KW - Neuroimaging KW - Neurological diseases KW - Stroke KW - Magnetic resonance imaging KW - Animal models KW - Tumors KW - Embryogenesis KW - Inflammatory diseases KW - Reviews KW - N.M.R. KW - N3 11023:Neurogenetics KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21067176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=MRI+of+mouse+models+of+neurological+disorders&rft.au=Anderson%2C+Stasia+A%3BFrank%2C+Joseph+A&rft.aulast=Anderson&rft.aufirst=Stasia&rft.date=2007-05-01&rft.volume=20&rft.issue=3&rft.spage=200&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=09523480&rft_id=info:doi/10.1002%2Fnbm.1167 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Animal models; Neuroimaging; Neurological diseases; Magnetic resonance imaging; Reviews; Central nervous system; Stroke; Inflammatory diseases; N.M.R.; Tumors; Embryogenesis DO - http://dx.doi.org/10.1002/nbm.1167 ER - TY - JOUR T1 - T2-prepared SSFP improves diagnostic confidence in edema imaging in acute myocardial infarction compared to turbo spin echo AN - 20857446; 8368462 AB - T2-weighted MRI of edema in acute myocardial infarction (MI) provides a means of differentiating acute and chronic MI, and assessing the area at risk of infarction. Conventional T2-weighted imaging of edema uses a turbo spin-echo (TSE) readout with dark-blood preparation. Clinical applications of dark-blood TSE methods can be limited by artifacts such as posterior wall signal loss due to through-plane motion, and bright subendocardial artifacts due to stagnant blood. Single-shot imaging with a T2-prepared SSFP readout provides an alternative to dark-blood TSE and may be conducted during free breathing. We hypothesized that T2-prepared SSFP would be a more reliable method than dark-blood TSE for imaging of edema in patients with MI. In patients with MI (22 acute and nine chronic MI cases), T2-weighted imaging with both methods was performed prior to contrast administration and delayed-enhancement imaging. The T2-weighted images using TSE were nondiagnostic in three of 31 cases, while six additional cases rated as being of diagnostic quality yielded incorrect diagnoses. In all 31 cases the T2-prepared SSFP images were rated as diagnostic quality, correctly differentiated acute or chronic MI, and correctly determined the coronary territory. Free-breathing T2-prepared SSFP provides T2-weighted images of acute MI with fewer artifacts and better diagnostic accuracy than conventional dark-blood TSE. JF - Magnetic Resonance in Medicine AU - Kellman, Peter AU - Aletras, Anthony H AU - Mancini, Christine AU - McVeigh, Elliot R AU - Arai, Andrew E AD - Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, kellman@nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 891 EP - 897 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 57 IS - 5 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Blood KW - Respiration KW - Magnetic resonance imaging KW - Therapeutic applications KW - Edema KW - Territory KW - N.M.R. KW - Myocardial infarction KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20857446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=T2-prepared+SSFP+improves+diagnostic+confidence+in+edema+imaging+in+acute+myocardial+infarction+compared+to+turbo+spin+echo&rft.au=Kellman%2C+Peter%3BAletras%2C+Anthony+H%3BMancini%2C+Christine%3BMcVeigh%2C+Elliot+R%3BArai%2C+Andrew+E&rft.aulast=Kellman&rft.aufirst=Peter&rft.date=2007-05-01&rft.volume=57&rft.issue=5&rft.spage=891&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21215 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Edema; Myocardial infarction; Magnetic resonance imaging; N.M.R.; Blood; Territory; Respiration; Therapeutic applications DO - http://dx.doi.org/10.1002/mrm.21215 ER - TY - JOUR T1 - Optimal methods for the preservation of cartilage samples in MRI and correlative biochemical studies AN - 20857401; 8368459 AB - MRI studies of cartilage require the prevention of sample degradation before and during scanning and during shipment for correlative studies. Methods to achieve this include immersion in protease inhibitors (PIs), refrigeration, and freezing. In this study, bovine nasal cartilage (BNC) samples were stored in Dulbecco's phosphate-buffered saline (DPBS), DPBS with standard PIs, or PI solution with GM6001, a potent metalloproteinase inhibitor. For each buffer, three samples were scanned at +4DGC and stored at +4DGC or at -20DGC with thawing prior to imaging. T2 and magnetization transfer (MT) rate, km, were measured weekly over 4 months, after which time water and glycosaminoglycan (GAG) contents were compared with those of matching tissue excised pre-storage. Samples in DPBS exhibited increased T2 (+33.6% after 1 month at +4DGC, P = 0.040) and decreased km (-20.6%, P = 0.004), while refrigeration in DPBS with PI and GM6001 yielded good stability (T2: +2.7%, P = 0.874; km: -4.2%, P = 0.654 after 108 days at +4DGC). Water content increased while GAG content markedly decreased in all samples. Thus, stability in cartilage MRI parameters can be optimized with appropriate storage conditions, but storage time should nonetheless be minimized. JF - Magnetic Resonance in Medicine AU - Fishbein, Kenneth W AU - Canuto, Holly C AU - Bajaj, Preeti AU - Camacho, Nancy Pleshko AU - Spencer, Richard G AD - National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA, spencerri@grc.nia.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 866 EP - 873 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 57 IS - 5 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Refrigeration KW - Cartilage KW - Magnetic resonance imaging KW - Thawing KW - Glycosaminoglycans KW - N.M.R. KW - Proteinase inhibitors KW - Freezing KW - Water content KW - Metalloproteinase KW - Scanning KW - Storage conditions KW - Immersion KW - Preservation KW - W 30910:Imaging KW - T 2030:Cartilage and Cartilage Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20857401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Optimal+methods+for+the+preservation+of+cartilage+samples+in+MRI+and+correlative+biochemical+studies&rft.au=Fishbein%2C+Kenneth+W%3BCanuto%2C+Holly+C%3BBajaj%2C+Preeti%3BCamacho%2C+Nancy+Pleshko%3BSpencer%2C+Richard+G&rft.aulast=Fishbein&rft.aufirst=Kenneth&rft.date=2007-05-01&rft.volume=57&rft.issue=5&rft.spage=866&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21189 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Cartilage; Magnetic resonance imaging; Refrigeration; Thawing; Metalloproteinase; Scanning; Glycosaminoglycans; N.M.R.; Immersion; Proteinase inhibitors; Water content; Freezing; Storage conditions; Preservation DO - http://dx.doi.org/10.1002/mrm.21189 ER - TY - JOUR T1 - Cyclooxygenase-2 deficiency increases epidermal apoptosis and impairs recovery following acute UVB exposure AN - 20638584; 9378441 AB - The cyclooxygenases, COX-1 and COX-2, are involved in cutaneous responses to both acute and chronic UV exposure. In the present study, wild-type (WT), COX-1-/- and COX-2-/- mice were used to determine the influence of the individual isoform on mouse skin responses to acute UVB treatment. Immunohistochemistry and Western analysis indicated that COX-2, and not COX-1, was induced by UVB (2.5 or 5.0 kJ/m2), but that COX-1 remained the major source of prostaglandin E2 production. UVB exposure significantly increased epidermal apoptosis in all genotypes compared to untreated mice. However, while the number of apoptotic cells in WT and COX-1-/- mice were about equal, the number of apoptotic cells was 2.5-fold greater in COX-2-/- mice. Apoptosis in WT and COX-2-/- mice peaked at 24 h post-exposure. The increased apoptosis and reduced proliferation in COX-2-/- mice resulted in about a 50% decrease in epidermal thickness at 24-48 h post-exposure compared to about a 50% increase in epidermal thickness in WT mice. UVB-induced cell replication, as measured by BrdU labeling, was reduced in COX-2-/- compared to WT mice at 24-96 h. However, by 96 h post-exposure, both WT and COX-2-/- mice showed epidermal hyperplasia. The data indicate that COX-2 induction initially protects against the acute sunburn effects of UVB, but that continuous induction of COX-2 may contribute to skin cancer in chronic UVB exposure. JF - Molecular Carcinogenesis AU - Akunda, Jacqueline K AU - Chun, Kyung-Soo AU - Sessoms, Alisha R AU - Lao, Huei-Chen AU - Fischer, Susan M AU - Langenbach, Robert AD - Laboratory of Molecular Carcinogenesis, NIEHS-NIH, Research Triangle Park, North Carolina 27709 Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 354 EP - 362 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 46 IS - 5 SN - 0899-1987, 0899-1987 KW - Toxicology Abstracts KW - Cyclooxygenase-2 KW - Hyperplasia KW - Apoptosis KW - Data processing KW - Replication KW - Carcinogenesis KW - Skin cancer KW - Prostaglandin E2 KW - Genotypes KW - Immunohistochemistry KW - Cyclooxygenase-1 KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20638584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Carcinogenesis&rft.atitle=Cyclooxygenase-2+deficiency+increases+epidermal+apoptosis+and+impairs+recovery+following+acute+UVB+exposure&rft.au=Akunda%2C+Jacqueline+K%3BChun%2C+Kyung-Soo%3BSessoms%2C+Alisha+R%3BLao%2C+Huei-Chen%3BFischer%2C+Susan+M%3BLangenbach%2C+Robert&rft.aulast=Akunda&rft.aufirst=Jacqueline&rft.date=2007-05-01&rft.volume=46&rft.issue=5&rft.spage=354&rft.isbn=&rft.btitle=&rft.title=Molecular+Carcinogenesis&rft.issn=08991987&rft_id=info:doi/10.1002%2Fmc.20290 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cyclooxygenase-2; Hyperplasia; Data processing; Apoptosis; Replication; Carcinogenesis; Skin cancer; Genotypes; Prostaglandin E2; Immunohistochemistry; Cyclooxygenase-1 DO - http://dx.doi.org/10.1002/mc.20290 ER - TY - JOUR T1 - Global analysis of community-associated methicillin-resistant Staphylococcus aureus exoproteins reveals molecules produced in vitro and during infection AN - 20555749; 7894333 AB - Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is a threat to human health worldwide. Although progress has been made, mechanisms of CA-MRSA pathogenesis are poorly understood and a comprehensive analysis of CA-MRSA exoproteins has not been conducted. To address that deficiency, we used proteomics to identify exoproteins made by MW2 (USA400) and LAC (USA300) during growth in vitro. Two hundred and fifty unique exoproteins were identified by 2-dimensional gel electrophoresis coupled with automated direct infusion-tandem mass spectrometry (ADI-MSMS) analysis. Eleven known virulence-related exoproteins differed in abundance between the strains, including alpha-haemolysin (Hla), collagen adhesin (Cna), staphylokinase (Sak), coagulase (Coa), lipase (Lip), enterotoxin C3 (Sec3), enterotoxin Q (Seq), V8 protease (SspA) and cysteine protease (SspB). Mice infected with MW2 or LAC produced antibodies specific for known or putative virulence factors, such as autolysin (Atl), Cna, Ear, ferritin (Ftn), Lip, 1-phosphatidylinositol phosphodiesterase (Plc), Sak, Sec3 and SspB, indicating the exoproteins are made during infection in vivo. We used confocal microscopy to demonstrate aureolysin (Aur), Hla, SspA and SspB are produced following phagocytosis by human neutrophils, thereby linking exoprotein production in vitro with that during host-pathogen interaction. We conclude that the exoproteins identified herein likely account in part for the success of CA-MRSA as a human pathogen. JF - Cellular Microbiology AU - Burlak, Christopher AU - Hammer, Carl H AU - Robinson, Mary-Ann AU - Whitney, Adeline R AU - McGavin, Martin J AU - Kreiswirth, Barry N AU - DeLeo, Frank R AD - Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA., fdeleo@niaid.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 1172 EP - 1190 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 9 IS - 5 SN - 1462-5814, 1462-5814 KW - Microbiology Abstracts B: Bacteriology KW - Histocompatibility antigen HLA KW - Adhesins KW - virulence factors KW - Drug resistance KW - Abundance KW - Ear KW - Infection KW - Mass spectroscopy KW - Collagen KW - 1-Phosphatidylinositol phosphodiesterase KW - Coagulase KW - Lip KW - Staphylococcus aureus KW - Phagocytosis KW - Cysteine proteinase KW - Aureolysin KW - Leukocytes (neutrophilic) KW - Pathogens KW - Gel electrophoresis KW - Triacylglycerol lipase KW - Autolysins KW - Antibodies KW - Host-pathogen interactions KW - Confocal microscopy KW - staphylokinase KW - Ferritin KW - Enterotoxins KW - proteomics KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20555749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+Microbiology&rft.atitle=Global+analysis+of+community-associated+methicillin-resistant+Staphylococcus+aureus+exoproteins+reveals+molecules+produced+in+vitro+and+during+infection&rft.au=Burlak%2C+Christopher%3BHammer%2C+Carl+H%3BRobinson%2C+Mary-Ann%3BWhitney%2C+Adeline+R%3BMcGavin%2C+Martin+J%3BKreiswirth%2C+Barry+N%3BDeLeo%2C+Frank+R&rft.aulast=Burlak&rft.aufirst=Christopher&rft.date=2007-05-01&rft.volume=9&rft.issue=5&rft.spage=1172&rft.isbn=&rft.btitle=&rft.title=Cellular+Microbiology&rft.issn=14625814&rft_id=info:doi/10.1111%2Fj.1462-5822.2006.00858.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Adhesins; virulence factors; Drug resistance; Abundance; Ear; Infection; Mass spectroscopy; Collagen; Coagulase; 1-Phosphatidylinositol phosphodiesterase; Lip; Phagocytosis; Cysteine proteinase; Aureolysin; Leukocytes (neutrophilic); Pathogens; Gel electrophoresis; Autolysins; Triacylglycerol lipase; Antibodies; Host-pathogen interactions; Confocal microscopy; staphylokinase; Enterotoxins; Ferritin; proteomics; Staphylococcus aureus DO - http://dx.doi.org/10.1111/j.1462-5822.2006.00858.x ER - TY - JOUR T1 - Natural Products Active in Aberrant c-Kit Signaling AN - 20505093; 7995814 AB - Development of modulators of constitutively active, kinase domain mutants of c-Kit has proved to be very difficult. Therefore, a high-throughput differential cytotoxicity assay was developed to screen for compounds that preferentially kill cells expressing constitutively active c-Kit. The cells used in the assay, murine IC2 mast cells, express either the D814Y activating mutation (functionally equivalent to human D816Y) or wild type protein. This assay is robust and highly reproducible. When applied to libraries of natural product extracts (followed by assay-guided fractionation), two differentially active compounds were identified. To assess possible mechanisms of action, the active compounds were tested for inhibitory activity against a panel of signaling enzymes (including wild type and mutant c-Kit). Neither of the compounds significantly affected any of the 73 enzymes tested. The effects of commercially available modulators of known signaling components were also assessed using the screening assay. None of these inhibitors reproduced the differential activity seen with the natural products. Finally, both compounds were found to affect mitochondrial potential in cells expressing c-Kit super(D814Y). These results suggest that the newly identified natural products may provide new avenues for intervention in aberrant c-Kit signaling pathways. JF - Chemical Biology & Drug Design AU - Henrich, Curtis J AU - Goncharova, Ekaterina I AU - Wilson, Jennifer A AU - Gardella, Roberta S AU - Johnson, Tanya R AU - McMahon, James B AU - Takada, Kentaro AU - Bokesch, Heidi R AU - Gustafson, Kirk R AD - Molecular Targets Development Program, NCI-Frederick, Frederick, MD 21702, USA Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 321 EP - 330 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 69 IS - 5 SN - 1747-0277, 1747-0277 KW - Biotechnology Research Abstracts (through 1992) KW - c-Kit protein KW - Cytotoxicity KW - Mast cells KW - Mitochondria KW - Enzymes KW - Drug development KW - natural products KW - Mutation KW - Signal transduction KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20505093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Biology+%26+Drug+Design&rft.atitle=Natural+Products+Active+in+Aberrant+c-Kit+Signaling&rft.au=Henrich%2C+Curtis+J%3BGoncharova%2C+Ekaterina+I%3BWilson%2C+Jennifer+A%3BGardella%2C+Roberta+S%3BJohnson%2C+Tanya+R%3BMcMahon%2C+James+B%3BTakada%2C+Kentaro%3BBokesch%2C+Heidi+R%3BGustafson%2C+Kirk+R&rft.aulast=Henrich&rft.aufirst=Curtis&rft.date=2007-05-01&rft.volume=69&rft.issue=5&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Chemical+Biology+%26+Drug+Design&rft.issn=17470277&rft_id=info:doi/10.1111%2Fj.1747-0285.2007.00508.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - c-Kit protein; natural products; Signal transduction; Drug development; Enzymes; Mitochondria; Mast cells; Cytotoxicity; Mutation DO - http://dx.doi.org/10.1111/j.1747-0285.2007.00508.x ER - TY - JOUR T1 - Crustacean fish parasites from Segara Anakan Lagoon, Java, Indonesia AN - 20455458; 7728407 AB - The present study Is the first investigation on ectoparasites of commercial important fish from Segara Anakan, a brackish water lagoon located at the southern coast of Java, Indonesia. Eight economically important marine fish species (Mugil cephalus, Siganus javus, Scatophagus argus, Caranx sexfasclatus, Lutjanus johnii, Eleutheronema tetradactylum, Johnius coitor, and Epinephelus coioides) were examined for crustacean parasites. Prevalence and intensity data for each parasite species are given, together with an analysis of the origin and possible transmission pathways. A highly divers copepod fauna consisting of 23 different species and two isopods was found. All fish species were at least infested with two copepod species, with the exception of L johnii, S. argus, and M. cephalus. With seven and six species, respectively, they harboured the most species-rich ectoparasite fauna. The copepods Ergasilus sp. 3 and Caligus acanthopagri on S. argus showed the highest prevalence (78.6) and intensity [17.8 (1-233) and 5.3 (1-22)] of infestation. The recorded parasite fauna is represented by marine, brackish water, and probably also freshwater components. The brackish water environment of Segara Anakan does not prevent disease outbreaks due to parasitic copepods by preventing pathogenic marine or freshwater species to enter the lagoon. This might cause fish health problems if the Segara Anakan Lagoon would be developed for finfish mariculture in future. JF - Parasitology Research AU - Yuniar, A T AU - Palm, H W AU - Walter, T AD - Center for Tropical Marine Ecology, Fahrenheitstrasse 6, 28359 Bremen, Germany, hpalm@indo.nei.id Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 1193 EP - 1204 VL - 100 IS - 6 SN - 0932-0113, 0932-0113 KW - Argustfish KW - Striped mullet KW - Ecology Abstracts; ASFA Aquaculture Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Ergasilus KW - ISEW, Indonesia KW - Lagoons KW - Disease transmission KW - Isopoda KW - Marine fish KW - Computer programs KW - Eleutheronema tetradactylum KW - Ectoparasites KW - Interspecific relationships KW - Copepoda KW - Lutjanus johnii KW - Marine crustaceans KW - Coasts KW - Freshwater environments KW - Scatophagus argus KW - Brackish KW - Caligus KW - Infestation KW - Fish diseases KW - Aquaculture development KW - Siganus javus KW - Mugil cephalus KW - Epinephelus coioides KW - Brackish water KW - Coastal lagoons KW - ectoparasites KW - D 04040:Ecosystem and Ecology Studies KW - Q1 08587:Diseases of Cultured Organisms KW - Q3 08587:Diseases of Cultured Organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20455458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Parasitology+Research&rft.atitle=Crustacean+fish+parasites+from+Segara+Anakan+Lagoon%2C+Java%2C+Indonesia&rft.au=Yuniar%2C+A+T%3BPalm%2C+H+W%3BWalter%2C+T&rft.aulast=Yuniar&rft.aufirst=A&rft.date=2007-05-01&rft.volume=100&rft.issue=6&rft.spage=1193&rft.isbn=&rft.btitle=&rft.title=Parasitology+Research&rft.issn=09320113&rft_id=info:doi/10.1007%2Fs00436-006-0391-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Marine fish; Interspecific relationships; Aquaculture development; Fish diseases; Ectoparasites; Coastal lagoons; Marine crustaceans; Computer programs; Infestation; Freshwater environments; Brackish water; Lagoons; ectoparasites; Coasts; Disease transmission; Isopoda; Ergasilus; Eleutheronema tetradactylum; Siganus javus; Scatophagus argus; Mugil cephalus; Copepoda; Epinephelus coioides; Lutjanus johnii; Caligus; ISEW, Indonesia; Brackish DO - http://dx.doi.org/10.1007/s00436-006-0391-9 ER - TY - JOUR T1 - Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIV AN - 20433694; 7763385 AB - Zidovudine-based antiretroviral therapies (ARTs) for treatment of HIV-infected pregnant women have markedly reduced mother-to-child transmission of the human immunodeficiency virus (HIV-1) from 25% to <1%. However, zidovudine (ZDV; AZT), a nucleoside analogue, induces chromosomal damage, gene mutations, and cancer in animals following direct or transplacental exposure. To determine if chromosomal damage is induced by ZDV in infants exposed transplacentally, we evaluated micronucleated reticulocyte frequencies (%MN-RET) in 16 HIV-infected ART-treated mother-infant pairs. Thirteen women received prenatal ART containing ZDV; three received ART without ZDV. All infants received ZDV for 6 weeks postpartum. Venous blood was obtained from women at delivery and from infants at 1-3 days, 4-6 weeks, and 4-6 months of life; cord blood was collected immediately after delivery. Ten cord blood samples (controls) were obtained from infants of HIV-uninfected women who did not receive ART. %MN-RET was measured using a single laser 3-color flow cytometric system. Tenfold increases in %MN-RET were seen in women and infants who received ZDV-containing ART prenatally; no increases were detected in three women and infants who received prenatal ART without ZDV. Specifically, mean %MN-RET in cord blood of ZDV-exposed infants was 1.67 ± 0.34 compared with 0.16 ± 0.06 in non-ZDV ART-exposed infants (P = 0.006) and 0.12 ± 0.02 in control cord bloods (P < 0.0001). %MN-RET in ZDV-exposed newborns decreased over the first 6 months of life to levels comparable to cord blood controls. These results demonstrate that transplacentalZDV exposure is genotoxic in humans. Long-term monitoring of HIV-uninfected ZDV-exposed infants isrecommended to ensure their continued health. JF - Environmental and Molecular Mutagenesis AU - Witt, Kristine L AU - Cunningham, Coleen K AU - Patterson, Kristine B AU - Kissling, Grace E AU - Dertinger, Stephen D AU - Livingston, Elizabeth AU - Bishop, Jack B AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, bishop@niehs.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 322 EP - 329 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 48 IS - 3-4 SN - 0893-6692, 0893-6692 KW - Virology & AIDS Abstracts; Toxicology Abstracts KW - Point mutation KW - Erythrocytes KW - antiretroviral therapy KW - Genotoxicity KW - Zidovudine KW - Cancer KW - Pregnancy KW - Disease transmission KW - Mutagenesis KW - Flow cytometry KW - nucleoside analogs KW - Cord blood KW - Postpartum KW - Human immunodeficiency virus 1 KW - Lasers KW - Neonates KW - Reticulocytes KW - Infants KW - V 22360:AIDS and HIV KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20433694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Elevated+frequencies+of+micronucleated+erythrocytes+in+infants+exposed+to+zidovudine+in+utero+and+postpartum+to+prevent+mother-to-child+transmission+of+HIV&rft.au=Witt%2C+Kristine+L%3BCunningham%2C+Coleen+K%3BPatterson%2C+Kristine+B%3BKissling%2C+Grace+E%3BDertinger%2C+Stephen+D%3BLivingston%2C+Elizabeth%3BBishop%2C+Jack+B&rft.aulast=Witt&rft.aufirst=Kristine&rft.date=2007-05-01&rft.volume=48&rft.issue=3-4&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20266 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genotoxicity; antiretroviral therapy; Erythrocytes; Point mutation; Zidovudine; Cancer; Mutagenesis; Disease transmission; Pregnancy; Cord blood; nucleoside analogs; Flow cytometry; Postpartum; Lasers; Neonates; Reticulocytes; Infants; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1002/em.20266 ER - TY - JOUR T1 - Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from Swiss (CD-1) male mice exposed transplacentally to AZT AN - 20413951; 7763383 AB - A transplacental carcinogenicity study was conducted by exposing pregnant Swiss (CD-1) mice to 0, 50, 100, 200, or 300 mg of 3-azido-3-deoxythymidine (AZT)/kg bw/day, through a 18 to 19-day gestation [National Toxicology Program, NIH Pub. No. 04-4458, 2004]. The incidences of alveolar/bronchiolar adenomas and carcinomas, in the 200 and 300 mg/kg male treatment groups, were significantly greater than that of the controls. In the present study, we evaluated the benign and malignant lung neoplasms from this bioassay for point mutations, in the K-ras and p53 cancer genes that are often mutated in human lung tumors. K-ras and p53 mutations were detected by cycle sequencing of polymerase chain reaction-amplified DNA, isolated from formalin-fixed, paraffin-embedded neoplasms. K-ras mutations were detected in 25 of 38 (66%) of the AZT-induced lung tumors, and the predominant mutations were codon 12 GT transversions. p53 mutations were detected in 32 of 38 (84%) of the AZT-induced lung tumors, with the predominant mutations being exon 8, codon 285 AT transversions, and exon 6, codon 198 TA transversions. No K-ras or p53 mutations were detected in five tumors, examined from control mice. The patterns of mutations identified in the lung tumors suggest that incorporation of AZT or its metabolites into DNA, oxidative stress, and genomic instability may be the contributing factors to the mutation profile and development of lung cancer in these mice. JF - Environmental and Molecular Mutagenesis AU - Hong, Hue-Hua L AU - Dunnick, June AU - Herbert, Ronald AU - Devereux, Theodora R AU - Kim, Yongbaek AU - Sills, Robert C AD - Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, hong@niehs.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 299 EP - 306 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 48 IS - 3-4 SN - 0893-6692, 0893-6692 KW - Genetics Abstracts; Toxicology Abstracts KW - Exons KW - Point mutation KW - Zidovudine KW - Metabolites KW - Tumors KW - Transversion KW - Alveoli KW - Pregnancy KW - p53 protein KW - Carcinoma KW - Mutagenesis KW - K-Ras protein KW - DNA sequencing KW - Genomic instability KW - Oxidative stress KW - Carcinogenicity KW - Gestation KW - DNA KW - Codons KW - Adenoma KW - Lung cancer KW - Benign KW - X 24310:Pharmaceuticals KW - G 07710:Chemical Mutagenesis & Radiation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20413951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Genetic+alterations+in+K-ras+and+p53+cancer+genes+in+lung+neoplasms+from+Swiss+%28CD-1%29+male+mice+exposed+transplacentally+to+AZT&rft.au=Hong%2C+Hue-Hua+L%3BDunnick%2C+June%3BHerbert%2C+Ronald%3BDevereux%2C+Theodora+R%3BKim%2C+Yongbaek%3BSills%2C+Robert+C&rft.aulast=Hong&rft.aufirst=Hue-Hua&rft.date=2007-05-01&rft.volume=48&rft.issue=3-4&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20197 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Exons; Point mutation; Zidovudine; Metabolites; Tumors; Alveoli; Transversion; Mutagenesis; Carcinoma; p53 protein; Pregnancy; K-Ras protein; DNA sequencing; Genomic instability; Carcinogenicity; Oxidative stress; Gestation; Codons; DNA; Adenoma; Benign; Lung cancer DO - http://dx.doi.org/10.1002/em.20197 ER - TY - JOUR T1 - Trp/Met/Phe Hot Spots in Protein-Protein Interactions: Potential Targets in Drug Design AN - 20328503; 7658421 AB - Protein-protein interactions are crucial to biological functions. Consequently, designing drugs to control protein-protein interactions is receiving increasing attention. Protein structures can associate in different ways. Analysis of the structures of proteinprotein complexes using amino acid sequence order-independent multiple structural comparison algorithms, led us to conclude that the amino acids Trp, Met, and Phe are important for protein- protein interactions. Hence, in principle, drug design targeting the Trp/Met/Phe should modulate protein functions effectively. Several clusters of the Trp/Met/Phe residues are involved in the p53 protein-protein interactions. The best example in this regard is the Phe19/Trp23 of p53, which binds to transcriptional factors and to the MDM2 protein. In the HIV related proteins, the Trp/Met/Phe residues have roles in the dimerization of the transcriptase (p51/p66) and in cell-fusion processes, including the gp120-CD4 interaction and the gp41 six-helix bundle formation. Trp/Met/Phe residues are preferred in `normal' functional protein-protein interactions and they also appear to be exploited in amyloid formation, especially the phenylalanine. Comparison of binding propensity and amyloid formation preference reveals that apart from Lysine, Isoleucine is the least structurally conserved in protein binding sites and has a high propensity in sequences forming amyloids. Thus, this may suggest that nature tends to avoid Ile conservation in protein-protein interaction to avoid amyloid formation. In this regards, Trp/Met/Phe as well as Ile may be targeted to modulate protein-protein interaction. JF - Current Topics in Medicinal Chemistry AU - Ma, Buyong AU - Nussinov, Ruth AD - Basic Research Program,SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program,NCI-Frederick, Frederick, MD 21702, Sackler Inst. of Molecular Medicine,Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, T Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 999 EP - 1005 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 7 IS - 10 SN - 1568-0266, 1568-0266 KW - Biotechnology and Bioengineering Abstracts KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20328503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Topics+in+Medicinal+Chemistry&rft.atitle=Trp%2FMet%2FPhe+Hot+Spots+in+Protein-Protein+Interactions%3A+Potential+Targets+in+Drug+Design&rft.au=Ma%2C+Buyong%3BNussinov%2C+Ruth&rft.aulast=Ma&rft.aufirst=Buyong&rft.date=2007-05-01&rft.volume=7&rft.issue=10&rft.spage=999&rft.isbn=&rft.btitle=&rft.title=Current+Topics+in+Medicinal+Chemistry&rft.issn=15680266&rft_id=info:doi/10.2174%2F156802607780906717 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.2174/156802607780906717 ER - TY - JOUR T1 - Structure of colicin I receptor bound to the R-domain of colicin Ia: implications for protein import AN - 20326383; 7473897 AB - Colicin Ia is a 69 kDa protein that kills susceptible Escherichia coli cells by binding to a specific receptor in the outer membrane, colicin I receptor (70 kDa), and subsequently translocating its channel forming domain across the periplasmic space, where it inserts into the inner membrane and forms a voltage-dependent ion channel. We determined crystal structures of colicin I receptor alone and in complex with the receptor binding domain of colicin Ia. The receptor undergoes large and unusual conformational changes upon colicin binding, opening at the cell surface and positioning the receptor binding domain of colicin Ia directly above it. We modelled the interaction with full-length colicin Ia to show that the channel forming domain is initially positioned 150 Aa above the cell surface. Functional data using full-length colicin Ia show that colicin I receptor is necessary for cell surface binding, and suggest that the receptor participates in translocation of colicin Ia across the outer membrane. JF - EMBO Journal AU - Buchanan, Susan K AU - Lukacik, Petra AU - Grizot, Sylvestre AU - Ghirlando, Rodolfo AU - Ali, Maruf M U AU - Barnard, Travis J AU - Jakes, Karen S AU - Kienker, Paul K AU - Esser, Lothar AD - Laboratory of Molecular Biology, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bethesda, MD, USA, skbuchan@helix.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 2594 EP - 2604 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 26 IS - 10 SN - 0261-4189, 0261-4189 KW - Microbiology Abstracts B: Bacteriology KW - active transport KW - colicin KW - outer membrane protein KW - protein import KW - TonB KW - Cell surface KW - Protein transport KW - Periplasmic space KW - Inner membranes KW - Outer membranes KW - Ion channels KW - Escherichia coli KW - Colicins KW - Crystal structure KW - Translocation KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20326383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EMBO+Journal&rft.atitle=Structure+of+colicin+I+receptor+bound+to+the+R-domain+of+colicin+Ia%3A+implications+for+protein+import&rft.au=Buchanan%2C+Susan+K%3BLukacik%2C+Petra%3BGrizot%2C+Sylvestre%3BGhirlando%2C+Rodolfo%3BAli%2C+Maruf+M+U%3BBarnard%2C+Travis+J%3BJakes%2C+Karen+S%3BKienker%2C+Paul+K%3BEsser%2C+Lothar&rft.aulast=Buchanan&rft.aufirst=Susan&rft.date=2007-05-01&rft.volume=26&rft.issue=10&rft.spage=2594&rft.isbn=&rft.btitle=&rft.title=EMBO+Journal&rft.issn=02614189&rft_id=info:doi/10.1038%2Fsj.emboj.7601693 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Protein transport; Cell surface; Periplasmic space; Inner membranes; Ion channels; Outer membranes; Crystal structure; Colicins; Translocation; Escherichia coli DO - http://dx.doi.org/10.1038/sj.emboj.7601693 ER - TY - JOUR T1 - Conjugating recombinant proteins to Pseudomonas aeruginosa ExoProtein A: A strategy for enhancing immunogenicity of malaria vaccine candidates AN - 20276782; 7640710 AB - Conjugation of polysaccharides to carrier proteins has been a successful approach for producing safe and effective vaccines. In an attempt to increase the immunogenicity of two malarial vaccine candidate proteins of Plasmodium falciparum, apical membrane antigen 1 (AMA1) to a blood stage vaccine candidate and surface protein 25 (Pfs25) a mosquito stage vaccine candidate, were each independently chemically conjugated to the mutant, nontoxic Pseudomonas aeruginosa ExoProtein A (rEPA). AMA1 is a large (66kD) relatively good immunogen in mice; Pfs25 is a poorly immunogenic protein when presented on alum to mice. Mice were immunized on days 0 and 28 with AMA1- or Pfs25-rE conjugates or unconjugated AMA1 or Pfs25, all formulated on Alhydrogel. Remarkably, sera from mice 14 days after the second immunization with Pfs25-rEPA conjugates displayed over a 1000-fold higher antibody titers as compared to unconjugated Pfs25. In contrast, AMA1 conjugated under the same conditions induced only a three-fold increase in antibody titers. When tested for functional activity, antibodies elicited by the AMA1-rE inhibited invasion of erythrocytes by blood-stage parasites and antibodies elicited by the Pfs25-rEPA conjugates blocked the development of the sexual stage parasites in the mosquito midgut. These results demonstrate that conjugation to rEPA induces a marked improvement in the antibody titer in mice for the poor immunogen (Pfs25) and for the larger protein (AMA1). These conjugates now need to be tested in humans to determine if mice are predictive of the response in humans. JF - Vaccine AU - Qian, Feng AU - Wu, Yimin AU - Muratova, Olga AU - Zhou, Hong AU - Dobrescu, Gelu AU - Duggan, Peter AU - Lynn, Lambert AU - Song, Guanhong AU - Zhang, Yanling AU - Reiter, Karine AU - MacDonald, Nicholas AU - Narum, David L AU - Long, Carole A AU - Miller, Louis H AU - Saul, Allan AU - Mullen, Gregory E D AD - Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Rockville, MD 20852, USA, gregory.mullen@kcl.ac.uk Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 3923 EP - 3933 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 25 IS - 20 SN - 0264-410X, 0264-410X KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Apical membrane antigen 1 KW - Parasites KW - sexual stages KW - Erythrocytes KW - Malaria KW - Polysaccharides KW - Aluminum sulfate KW - Midgut KW - Pseudomonas aeruginosa KW - Plasmodium falciparum KW - Immunization KW - Blood KW - Antibodies KW - Immunogenicity KW - Vaccines KW - K 03350:Immunology KW - F 06905:Vaccines KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20276782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Conjugating+recombinant+proteins+to+Pseudomonas+aeruginosa+ExoProtein+A%3A+A+strategy+for+enhancing+immunogenicity+of+malaria+vaccine+candidates&rft.au=Qian%2C+Feng%3BWu%2C+Yimin%3BMuratova%2C+Olga%3BZhou%2C+Hong%3BDobrescu%2C+Gelu%3BDuggan%2C+Peter%3BLynn%2C+Lambert%3BSong%2C+Guanhong%3BZhang%2C+Yanling%3BReiter%2C+Karine%3BMacDonald%2C+Nicholas%3BNarum%2C+David+L%3BLong%2C+Carole+A%3BMiller%2C+Louis+H%3BSaul%2C+Allan%3BMullen%2C+Gregory+E+D&rft.aulast=Qian&rft.aufirst=Feng&rft.date=2007-05-01&rft.volume=25&rft.issue=20&rft.spage=3923&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2007.02.073 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Pseudomonas aeruginosa; Plasmodium falciparum; Vaccines; Antibodies; Immunogenicity; Parasites; Midgut; Apical membrane antigen 1; sexual stages; Blood; Erythrocytes; Polysaccharides; Aluminum sulfate; Malaria; Immunization DO - http://dx.doi.org/10.1016/j.vaccine.2007.02.073 ER - TY - JOUR T1 - Analysis of fullerene-based nanomaterial in serum matrix by CE AN - 20140052; 7762706 AB - With the increasing interest in using nanoparticles as vehicles for drug delivery and image contrast agents, there is a need to develop assays for their detection and quantitation in complex matrices to facilitate monitoring their biodistribution. In this study, we developed a CE approach for the analysis of two nanoparticles: carboxyfullerene (C3) and dendrofullerene (DF1) in both standard solutions and a serum matrix. These highly soluble, charged C60 derivatives were characterized by CZE using either a bare or dynamically coated fused-silica capillaries. The resolution of both nanoparticles was slightly lower with the coated capillary; however, their migration times were faster. While separation of the DF1 nanoparticles using MEKC resulted in a greater number of observable peaks, the peak profile of C3 was basically unchanged regardless of whether SDS micelles were added to the running buffers or not. The MEKC and/or CZE assays were then used to quantitate the C3 and DF1 nanoparticles in spiked human serum samples. The quantitation of the nanoparticles was linear from 0-500g/mL with detection limits ranging from 0.5 to 6g/mL. JF - Electrophoresis AU - Chan, King C AU - Patri, Anil K AU - Veenstra, Timothy D AU - McNeil, Scott E AU - Issaq, Haleem J AD - Laboratory of Proteomics and Analytical Technologies, SAIC-Frederick Inc., NCI-Frederick, Frederick, MD, USA, chan@ncifcrf.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 1518 EP - 1524 PB - Wiley-VCH, Postfach 101161 Weinheim 69451 Germany, [mailto:info@wiley-vch.de], [URL:http://www.wiley-vch.de/publish/en/] VL - 28 IS - 10 SN - 0173-0835, 0173-0835 KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Carboxyfullerene KW - Micelles KW - Running KW - Sodium lauryl sulfate KW - Contrast media KW - nanoparticles KW - Capillaries KW - Quantitation KW - Migration KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20140052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Electrophoresis&rft.atitle=Analysis+of+fullerene-based+nanomaterial+in+serum+matrix+by+CE&rft.au=Chan%2C+King+C%3BPatri%2C+Anil+K%3BVeenstra%2C+Timothy+D%3BMcNeil%2C+Scott+E%3BIssaq%2C+Haleem+J&rft.aulast=Chan&rft.aufirst=King&rft.date=2007-05-01&rft.volume=28&rft.issue=10&rft.spage=1518&rft.isbn=&rft.btitle=&rft.title=Electrophoresis&rft.issn=01730835&rft_id=info:doi/10.1002%2Felps.200600724 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Drug delivery; Carboxyfullerene; Micelles; Running; Contrast media; Sodium lauryl sulfate; Migration; Quantitation; Capillaries; nanoparticles DO - http://dx.doi.org/10.1002/elps.200600724 ER - TY - JOUR T1 - Distinct roles of HDAC complexes in promoter silencing, antisense suppression and DNA damage protection AN - 20126654; 7386132 AB - Histone acetylation is important in regulating DNA accessibility. Multifunctional Sin3 proteins bind histone deacetylases (HDACs) to assemble silencing complexes that selectively target chromatin. We show that, in fission yeast, an essential HDAC, Clr6, exists in two distinct Sin3 core complexes. Complex I contains an essential Sin3 homolog, Pst1, and other factors, and predominantly targets gene promoters. Complex II contains a nonessential Sin3 homolog, Pst2, and several conserved proteins. It preferentially targets transcribed chromosomal regions and centromere cores. Defects in complex II abrogate global protective functions of chromatin, causing increased accessibility of DNA to genotoxic agents and widespread antisense transcripts that are processed by the exosome. Notably, the two Clr6 complexes differentially repress forward and reverse centromeric repeat transcripts, suggesting that these complexes regulate transcription in heterochromatin and euchromatin in similar manners, including suppression of spurious transcripts from cryptic start sites. JF - Nature Structural & Molecular Biology AU - Nicolas, Estelle AU - Yamada, Takatomi AU - Cam, Hugh P AU - FitzGerald, Peter C AU - Kobayashi, Ryuji AU - Grewal, Shiv I S AD - Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, US National Institutes of Health (NIH), Bethesda, Maryland 20892, USA., grewals@mail.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 372 EP - 380 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 14 IS - 5 SN - 1545-9993, 1545-9993 KW - fission yeast KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Euchromatin KW - Histone deacetylase KW - Heterochromatin KW - exosomes KW - Chromatin KW - Genotoxicity KW - Transcription KW - Antisense DNA KW - Centromeres KW - Acetylation KW - DNA damage KW - Promoters KW - Antisense KW - Schizosaccharomyces pombe KW - W 30940:Products KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20126654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Structural+%26+Molecular+Biology&rft.atitle=Distinct+roles+of+HDAC+complexes+in+promoter+silencing%2C+antisense+suppression+and+DNA+damage+protection&rft.au=Nicolas%2C+Estelle%3BYamada%2C+Takatomi%3BCam%2C+Hugh+P%3BFitzGerald%2C+Peter+C%3BKobayashi%2C+Ryuji%3BGrewal%2C+Shiv+I+S&rft.aulast=Nicolas&rft.aufirst=Estelle&rft.date=2007-05-01&rft.volume=14&rft.issue=5&rft.spage=372&rft.isbn=&rft.btitle=&rft.title=Nature+Structural+%26+Molecular+Biology&rft.issn=15459993&rft_id=info:doi/10.1038%2Fnsmb1239 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Histone deacetylase; Euchromatin; Heterochromatin; Chromatin; exosomes; Genotoxicity; Antisense DNA; Transcription; Centromeres; Promoters; DNA damage; Acetylation; Antisense; Schizosaccharomyces pombe DO - http://dx.doi.org/10.1038/nsmb1239 ER - TY - JOUR T1 - Tissue microarrays as a platform for proteomic investigation AN - 20089377; 7387746 AB - Tissue microarrays have become an essential tool in translational pathology. They are used to confirm results from other experimental platforms, such as expression microarrays, as well as a primary tool to explore the expression profile of proteins by immunohistochemical analysis. Tissue microarrays are routinely used molecular epidemiology, drug development and determining the diagnostic, prognostic and predictive value of new biomarkers. By applying traditional protein based assays, as well as novel assays to the platform, tissue microarrays have gained a new utility as a proteomic tool for both basic science as well as clinical investigation. This article will explore the new approaches that are being applied to tissue microarrays to, characterize the human proteome, and new technologies that allow tissue microarrays to function as a protein array. JF - Journal of Molecular Histology AU - Chung, Joon-Yong AU - Braunschweig, Till AU - Tuttle, Kimberly AU - Hewitt, Stephen M AD - National Cancer Institute, National Institutes of Health, MSC 4605, Bethesda, MD, 20892-4605, USA, genejock@helix.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 123 EP - 128 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 38 IS - 2 SN - 1567-2379, 1567-2379 KW - Biotechnology and Bioengineering Abstracts KW - Translation KW - Epidemiology KW - Drug development KW - proteomics KW - biomarkers KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20089377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Histology&rft.atitle=Tissue+microarrays+as+a+platform+for+proteomic+investigation&rft.au=Chung%2C+Joon-Yong%3BBraunschweig%2C+Till%3BTuttle%2C+Kimberly%3BHewitt%2C+Stephen+M&rft.aulast=Chung&rft.aufirst=Joon-Yong&rft.date=2007-05-01&rft.volume=38&rft.issue=2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Histology&rft.issn=15672379&rft_id=info:doi/10.1007%2Fs10735-006-9049-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Translation; Epidemiology; Drug development; proteomics; biomarkers DO - http://dx.doi.org/10.1007/s10735-006-9049-2 ER - TY - JOUR T1 - Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination AN - 20022506; 7763373 AB - Antiretroviral therapies based on nucleoside reverse transcriptase inhibitors (NRTIs), like zidovudine (3-azido-3-deoxythymidine; AZT) and lamivudine ((-)2,3-dideoxy-3-thiacytidine; 3TC), markedly reduce mother-to-child transmission of the human immunodeficiency virus (HIV). However, AZT induces damage in nuclear DNA of mice exposed in utero and postnatally, and mitochondrial DNA (mtDNA) damage has been observed in both human and mouse neonates following perinatal exposure to AZT and AZT/3TC in combination. To provide animal data modeling the NRTI-induced heart damage reported in human infants, we treated pregnant CD-1 mice throughout gestation and treated their pups by direct gavage from postnatal day (PND) 4 through PND 28 with daily doses of 150 mg/kg body weight (bw)/day AZT, 75 mg/kg bw/day 3TC, 125/62.5 mg/kg bw/day AZT/3TC, or the vehicle control. Half the pups were euthanized on PND 28; the remainder received no further dosing, and were euthanized at week 10. Heart tissue was collected, total DNA was extracted, and mtDNA copy number relative to nuclear DNA copy number, mtDNA damage, and mtDNA mutation assays were performed using PCR-based methods. Analyses revealed increases in mtDNA lesions in 4-week-old males and females treated with AZT or 3TC, but not in 10-week-old mice, suggesting that the damage resolved after treatment ceased. Interestingly, 10-week-old females treated with AZT/3TC had significant increases in mtDNA damage. Point mutations were elevated in 10-week-old females treated with AZT or AZT/3TC, but not 3TC; no increases in mutations were seen in either gender at 4 weeks of age. Our data suggest that AZT/3TC combination treatment produces greater mtDNA damage than either agent individually, and that female mice are more sensitive than males to AZT/3TC-induced mtDNA damage. JF - Environmental and Molecular Mutagenesis AU - Chan, Sherine S L AU - Santos, Janine H AU - Meyer, Joel N AU - Mandavilli, Bhaskar S AU - Cook Jr, Dennis L AU - McCash, Consuelo L AU - Kissling, Grace E AU - Nyska, Abraham AU - Foley, Julie F AU - van Houten, Bennett AU - Copeland, William C AU - Walker, Vernon E AU - Witt, Kristine L AU - Bishop, Jack B AD - Laboratory of Molecular Genetics, National Institute of Environmental HealthSciences, National Institutes of Health, Research Triangle Park, North Carolina, bishop@niehs.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 190 EP - 200 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 48 IS - 3-4 SN - 0893-6692, 0893-6692 KW - Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Heart KW - Age KW - Data processing KW - Point mutation KW - antiretroviral therapy KW - Mitochondria KW - Zidovudine KW - Lamivudine KW - Toxicity KW - Pregnancy KW - copy number KW - Mutagenesis KW - Disease transmission KW - DNA damage KW - Mitochondrial DNA KW - Perinatal exposure KW - Body weight KW - Human immunodeficiency virus KW - Gestation KW - Neonates KW - nucleoside reverse transcriptase inhibitors KW - Infants KW - V 22360:AIDS and HIV KW - X 24310:Pharmaceuticals KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20022506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Mitochondrial+toxicity+in+hearts+of+CD-1+mice+following+perinatal+exposure+to+AZT%2C+3TC%2C+or+AZT%2F3TC+in+combination&rft.au=Chan%2C+Sherine+S+L%3BSantos%2C+Janine+H%3BMeyer%2C+Joel+N%3BMandavilli%2C+Bhaskar+S%3BCook+Jr%2C+Dennis+L%3BMcCash%2C+Consuelo+L%3BKissling%2C+Grace+E%3BNyska%2C+Abraham%3BFoley%2C+Julie+F%3Bvan+Houten%2C+Bennett%3BCopeland%2C+William+C%3BWalker%2C+Vernon+E%3BWitt%2C+Kristine+L%3BBishop%2C+Jack+B&rft.aulast=Chan&rft.aufirst=Sherine+S&rft.date=2007-05-01&rft.volume=48&rft.issue=3-4&rft.spage=190&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20191 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Heart; Age; Data processing; antiretroviral therapy; Point mutation; Lamivudine; Zidovudine; Mitochondria; Toxicity; Disease transmission; Mutagenesis; copy number; Pregnancy; DNA damage; Mitochondrial DNA; Body weight; Perinatal exposure; Gestation; Neonates; Infants; nucleoside reverse transcriptase inhibitors; Human immunodeficiency virus DO - http://dx.doi.org/10.1002/em.20191 ER - TY - JOUR T1 - Mechanisms of genotoxicity of nucleoside reverse transcriptase inhibitors AN - 20007085; 7763376 AB - Nucleoside analogs were first approved by the U.S. Food and Drug Administration for use against HIV-AIDS in 1987. Since then, these agents, now commonly referred to as nucleoside reverse transcriptase inhibitors (NRTIs), have become essential components of the Highly Active Antiretroviral Therapy (HAART) drug combinations used for treatment of Human Immunodeficiency Virus-1 (HIV-1) infections. Their antiretroviral activity is likely two-fold: incorporation of the drug into viral DNA and inhibition of the viral reverse transcriptase. However, incorporation of the drug into host nuclear and mitochondrial DNA may be largely responsible for dose-limiting toxicities. Azidothymidine (AZT, 3-azido-3-deoxythymidine, zidovudine), the first NRTI approved for the therapy of HIV-1, is incorporated into DNA, causes mutations in the hypoxanthine-guanine phosphoribosyl-transferase (HPRT) and thymidine kinase (TK) genes, and induces micronuclei, chromosomal aberrations, sister chromatid exchange, shortened telomeres, and other genotoxic effects in cultured cells. Genomic instability would be predicted as a consequence of these events. Metabolic pathways that result in the phosphorylation of AZT play a crucial role in AZT-DNA incorporation, and may be altered after prolonged treatment. For example, thymidine kinase 1, the enzyme responsible for AZT mono-phosphorylation, is down-regulated during long-term exposure and appears to be associated with AZT-induced replication inhibition and the accumulation of cells in S-phase. Detailed information on the mechanisms underlying NRTI-associated antiretroviral efficacy, toxicity, and metabolic resistance were not available when AZT was first approved for use as an antiretroviral agent. Current insights, based on 15 years of research, may lead to intervention strategies to attenuate toxicity without altering drug efficacy. JF - Environmental and Molecular Mutagenesis AU - Olivero, Ofelia A AD - Carcinogen-DNA Interactions Section, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, NIH, Bethesda, Maryland, oliveroo@exchange.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 215 EP - 223 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 48 IS - 3-4 SN - 0893-6692, 0893-6692 KW - Virology & AIDS Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Sister chromatid exchange KW - Micronuclei KW - Immunodeficiency KW - Zidovudine KW - Thymidine kinase KW - Infection KW - Mutagenesis KW - Genomic instability KW - Antiviral agents KW - Phosphorylation KW - Human immunodeficiency virus 1 KW - Protein-tyrosine kinase KW - antiretroviral agents KW - Metabolic pathways KW - RNA-directed DNA polymerase KW - Chromosome aberrations KW - Replication KW - Genotoxicity KW - Enzymes KW - Toxicity KW - nucleoside analogs KW - Telomeres KW - Mitochondrial DNA KW - highly active antiretroviral therapy KW - Mutation KW - nucleoside reverse transcriptase inhibitors KW - V 22360:AIDS and HIV KW - X 24310:Pharmaceuticals KW - G 07710:Chemical Mutagenesis & Radiation KW - N 14835:Protein-Nucleic Acids Association UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20007085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Mechanisms+of+genotoxicity+of+nucleoside+reverse+transcriptase+inhibitors&rft.au=Olivero%2C+Ofelia+A&rft.aulast=Olivero&rft.aufirst=Ofelia&rft.date=2007-05-01&rft.volume=48&rft.issue=3-4&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20195 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Sister chromatid exchange; Micronuclei; Immunodeficiency; Zidovudine; Thymidine kinase; Infection; Mutagenesis; Genomic instability; Phosphorylation; Antiviral agents; antiretroviral agents; Protein-tyrosine kinase; Metabolic pathways; RNA-directed DNA polymerase; Chromosome aberrations; Replication; Genotoxicity; Enzymes; Toxicity; nucleoside analogs; Telomeres; Mitochondrial DNA; highly active antiretroviral therapy; Mutation; nucleoside reverse transcriptase inhibitors; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1002/em.20195 ER - TY - JOUR T1 - Morphological and molecular course of mitochondrial pathology in cultured human cells exposed long-term to Zidovudine AN - 20004476; 7763372 AB - Long-term use of antiretroviral nucleoside reverse transcriptase inhibitors (NRTIs) as therapy for human immunodeficiency virus-1 (HIV-1) infection is limited by mitochondrial toxicity. Here we document mitochondrial pathology during the long-term culture of human HeLa cells in the presence or absence of the NRTI Zidovudine(r) (AZT, 800 M) for up to 77-passages (p), with samples taken at early (p5-p11), middle (p36 and p37), and late (p70-p77) passages. Samples were analyzed for changes in mitochondrial morphology, mitochondrial (mt)DNA quantity, nuclear and mitochondrial gene expression, and mitochondrial membrane potential. Mitochondria showed abnormal proliferation at p5 and abnormal morphology p36. mtDNA quantity was increased at p5 and p11, and 65% depleted at p71. Hierarchical clustering of nuclear gene expression, examined at p37 by the NCI cDNA microarray in AZT-exposed cells, showed down-regulation of 13 out of 16 lipid-metabolizing genes, and up-regulation of most oxidative phosphorylation (OXPHOS) genes. OXPHOS genes encoded by mtDNA, examined at p5, p36, and p75 using the Mitochondrial Gene Mini Array, revealed up-regulation of genes coding for polypeptides of NADH dehydrogenase, ATP synthase, and cytochrome c oxidase. Mitochondrial membrane potential, monitored by JC1 staining, was elevated at p10 and p32, and essentially completely absent at p71. The data show that during chronic exposure of HeLa cells to AZT, a compensatory response was induced at the earlier passages (p5-p37), and by p71 there was widespread mitochondrial morphological damage, severe mtDNA depletion, and a substantial loss of mitochondrial membrane potential. JF - Environmental and Molecular Mutagenesis AU - Divi, Rao L AU - Haverkos, Kathryn J AU - Humsi, Juliette A AU - Shockley, Marie E AU - Thamire, Chandrasekhar AU - Nagashima, Kunio AU - Olivero, Ofelia A AU - Poirier, Miriam C AD - Carcinogen-DNA Interactions Section, National Cancer Institute, NIH, Bethesda, Maryland 20892, divir@exchange.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 179 EP - 189 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 48 IS - 3-4 SN - 0893-6692, 0893-6692 KW - Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Data processing KW - Oxidative phosphorylation KW - Immunodeficiency KW - Zidovudine KW - Mitochondria KW - Cytochrome-c oxidase KW - Cell culture KW - Toxicity KW - DNA microarrays KW - Mutagenesis KW - Gene expression KW - Mitochondrial DNA KW - NADH dehydrogenase KW - Antiviral agents KW - Chronic exposure KW - Human immunodeficiency virus 1 KW - ATP synthase KW - nucleoside reverse transcriptase inhibitors KW - Membrane potential KW - V 22360:AIDS and HIV KW - X 24310:Pharmaceuticals KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20004476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Morphological+and+molecular+course+of+mitochondrial+pathology+in+cultured+human+cells+exposed+long-term+to+Zidovudine&rft.au=Divi%2C+Rao+L%3BHaverkos%2C+Kathryn+J%3BHumsi%2C+Juliette+A%3BShockley%2C+Marie+E%3BThamire%2C+Chandrasekhar%3BNagashima%2C+Kunio%3BOlivero%2C+Ofelia+A%3BPoirier%2C+Miriam+C&rft.aulast=Divi&rft.aufirst=Rao&rft.date=2007-05-01&rft.volume=48&rft.issue=3-4&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20245 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Data processing; Oxidative phosphorylation; Immunodeficiency; Mitochondria; Zidovudine; Cell culture; Cytochrome-c oxidase; Toxicity; DNA microarrays; Mutagenesis; Gene expression; Mitochondrial DNA; NADH dehydrogenase; Antiviral agents; Chronic exposure; ATP synthase; Membrane potential; nucleoside reverse transcriptase inhibitors; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1002/em.20245 ER - TY - JOUR T1 - Impacts of Hurricanes Katrina and Rita on the microbial landscape of the New Orleans area AN - 19982576; 7421349 AB - Floodwaters in New Orleans from Hurricanes Katrina and Rita were observed to contain high levels of fecal indicator bacteria and microbial pathogens, generating concern about long-term impacts of these floodwaters on the sediment and water quality of the New Orleans area and Lake Pontchartrain. We show here that fecal indicator microbe concentrations in offshore waters from Lake Pontchartrain returned to prehurricane concentrations within 2 months of the flooding induced by these hurricanes. Vibrio and Legionella species within the lake were more abundant in samples collected shortly after the floodwaters had receded compared with samples taken within the subsequent 3 months; no evidence of a long-term hurricane-induced algal bloom was observed. Giardia and Cryptosporidium were detected in canal waters. Elevated levels of fecal indicator bacteria observed in sediment could not be solely attributed to impacts from floodwaters, as both flooded and nonflooded areas exhibited elevated levels of fecal indicator bacteria. Evidence from measurements of Bifidobacterium and bacterial diversity analysis suggest that the fecal indicator bacteria observed in the sediment were from human fecal sources. Epidemiologic studies are highly recommended to evaluate the human health effects of the sediments deposited by the floodwaters. JF - Proceedings of the National Academy of Sciences, USA AU - Sinigalliano, C D AU - Gidley, M L AU - Shibata, T AU - Whitman, D AU - Dixon, TH AU - Laws, E AU - Hou, A AU - Bachoon, D AU - Brand, L AU - Amaral-Zettler, L AU - Gast, R J AU - Steward, G F AU - Nigro, O D AU - Fujioka, R AU - Betancourt, W Q AU - Vithanage, G AU - Mathews, J AU - Fleming, LE AU - Solo-Gabriele, H M AD - National Science Foundation-National Institute of Environmental Health Sciences Oceans and Human Health Center, Rosenstiel School of Marine and Atmospheric Science, University of Miami, Coral Gables, FL 33149 Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 9029 EP - 9034 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 21 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Pollution Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Ecology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology KW - water quality KW - Algal blooms KW - Freshwater KW - Water quality KW - Bifidobacterium KW - Public health KW - Giardia KW - Lakes KW - Biological pollutants KW - Legionella KW - Sediment pollution KW - Fecal coliforms KW - Pathogenic bacteria KW - Landscape KW - Brackish KW - Pathogens KW - USA, Louisiana, New Orleans KW - Sediments KW - Canals KW - Hurricanes KW - Vibrio KW - Cryptosporidium KW - USA, Louisiana, Pontchartrain L. KW - Flooding KW - P 2000:FRESHWATER POLLUTION KW - A 01490:Miscellaneous KW - D 04040:Ecosystem and Ecology Studies KW - K 03450:Ecology KW - Q5 08524:Public health, medicines, dangerous organisms KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19982576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Impacts+of+Hurricanes+Katrina+and+Rita+on+the+microbial+landscape+of+the+New+Orleans+area&rft.au=Sinigalliano%2C+C+D%3BGidley%2C+M+L%3BShibata%2C+T%3BWhitman%2C+D%3BDixon%2C+TH%3BLaws%2C+E%3BHou%2C+A%3BBachoon%2C+D%3BBrand%2C+L%3BAmaral-Zettler%2C+L%3BGast%2C+R+J%3BSteward%2C+G+F%3BNigro%2C+O+D%3BFujioka%2C+R%3BBetancourt%2C+W+Q%3BVithanage%2C+G%3BMathews%2C+J%3BFleming%2C+LE%3BSolo-Gabriele%2C+H+M&rft.aulast=Sinigalliano&rft.aufirst=C&rft.date=2007-05-01&rft.volume=104&rft.issue=21&rft.spage=9029&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Algal blooms; Hurricanes; Pathogenic bacteria; Flooding; Biological pollutants; Water quality; Public health; Canals; Lakes; Landscape; Pathogens; Sediments; water quality; Sediment pollution; Fecal coliforms; Vibrio; Giardia; Cryptosporidium; Legionella; Bifidobacterium; USA, Louisiana, Pontchartrain L.; USA, Louisiana, New Orleans; Freshwater; Brackish ER - TY - JOUR T1 - Basic and clinical immunology: Causes of death in hyper-IgE syndrome AN - 19889288; 8593483 AB - Background: Hyper-IgE syndrome (HIES) is characterized by recurrent pyogenic infections, eczema, increased serum IgE levels, and a variety of connective tissue and skeletal system abnormalities. Little has been published regarding the causes of death in these patients or pathologic findings. Objective: To identify the cause of death in patients with HIES and to describe pathologic findings in fatal HIES. Methods: We reviewed the medical records and autopsy slides of 6 patients with HIES with autopsies performed at our institution. Results: All 6 patients with HIES were women and ranged in age from 24 to 40 years. All patients had a history of cystic lung disease and had pneumonia at the time of death, with Pseudomonas aeruginosa and fungal organisms predominating. Pulmonary fungal vascular invasion with fatal hemorrhage was observed in 3 patients, and metastatic fungal disease to the brain was observed in 2 patients caused by Aspergillus fumigatus and Scedosporium prolificans. Four patients had evidence of renal tubular injury, which was likely from amphotericin B toxicity; 3 patients had glomerulosclerosis; and 1 patient had 2 kidney angiomyolipomas. Conclusions: Our series highlights the important role Pseudomonas and Aspergillus species play in patients with HIES with cystic lung disease. Intensified antifungal and gram-negative bacterial prophylaxis need evaluation as possible strategies to prevent these infectious complications in patients with cystic lung disease. Clinical implications: Fungal and Pseudomonas infection of cystic lung disease in HIES may be life threatening, and the proper management and prevention of these infections need continued investigation. JF - Journal of Allergy and Clinical Immunology AU - Freeman, Alexandra F AU - Kleiner, David E AU - Nadiminti, Hari AU - Davis, Joie AU - Quezado, Martha AU - Anderson, Victoria AU - Puck, Jennifer M AU - Holland, Steven M AD - National Institutes of Allergy and Infectious Diseases National Cancer Institute National Human Genome Research Institute, National Institutes of Health, Bethesda, smh@nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 1234 EP - 1240 PB - American Academy of Allergy, Asthma and Immunology, 611 East Wells Street Milwalkee WI 53202 USA, [mailto:membership@aaaai.org], [URL:http://www.aaai.org] VL - 119 IS - 5 SN - 0091-6749, 0091-6749 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Aspergillus KW - hyper-IgE syndrome KW - immunodeficiency KW - pneumonia KW - Pseudomonas KW - Autopsy KW - Amphotericin B KW - Age KW - Injuries KW - medical records KW - Connective tissues KW - Lung diseases KW - Brain KW - Angiomyolipoma KW - Toxicity KW - Eczema KW - Hemorrhage KW - Metastases KW - Aspergillus fumigatus KW - Immunoglobulin E KW - Prophylaxis KW - Kidney KW - Recurrent infection KW - Pseudomonas aeruginosa KW - Scedosporium prolificans KW - Pneumonia KW - Job's syndrome KW - Vascular system KW - F 06925:Hypersensitivity KW - J 02400:Human Diseases KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19889288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Allergy+and+Clinical+Immunology&rft.atitle=Basic+and+clinical+immunology%3A+Causes+of+death+in+hyper-IgE+syndrome&rft.au=Freeman%2C+Alexandra+F%3BKleiner%2C+David+E%3BNadiminti%2C+Hari%3BDavis%2C+Joie%3BQuezado%2C+Martha%3BAnderson%2C+Victoria%3BPuck%2C+Jennifer+M%3BHolland%2C+Steven+M&rft.aulast=Freeman&rft.aufirst=Alexandra&rft.date=2007-05-01&rft.volume=119&rft.issue=5&rft.spage=1234&rft.isbn=&rft.btitle=&rft.title=Journal+of+Allergy+and+Clinical+Immunology&rft.issn=00916749&rft_id=info:doi/10.1016%2Fj.jaci.2006.12.666 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Amphotericin B; Autopsy; Age; Injuries; Connective tissues; medical records; Brain; Lung diseases; Eczema; Toxicity; Angiomyolipoma; Hemorrhage; Metastases; Immunoglobulin E; Kidney; Prophylaxis; Recurrent infection; Job's syndrome; Pneumonia; Vascular system; Aspergillus fumigatus; Pseudomonas aeruginosa; Scedosporium prolificans DO - http://dx.doi.org/10.1016/j.jaci.2006.12.666 ER - TY - JOUR T1 - A Cross-sectional Study of a Prototype Carcinogenic Human Papillomavirus E6/E7 Messenger RNA Assay for Detection of Cervical Precancer and Cancer AN - 19886763; 7417215 AB - PURPOSE: To evaluate carcinogenic human papillomavirus (HPV) mRNA for E6 and E7 mRNA detection on clinical specimens to identify women with cervical precancer and cancer. Experimental Design: We evaluated a prototype assay that collectively detects oncogenes E6/E7 mRNA for 14 carcinogenic HPV genotypes on a sample of liquid cytology specimens (n = 531), masked to clinical data and to the presence of HPV genotypes detected by PGMY09/11 L1 consensus primer PCR assay. RESULTS: We found an increasing likelihood of testing positive for carcinogenic HPV E6/E7 mRNA with increasing severity of cytology (P sub(Trend) < 0.0001) and histology (P sub(Trend) < 0.0001), with 94% of cervical intraepithelial neoplasia grade 3 (CIN3) histology cases (46 of 49) and all five cancer cases testing positive for carcinogenic HPV E6/E7 mRNA. Overall, fewer specimens tested positive for carcinogenic HPV E6/E7 mRNA than for carcinogenic HPV DNA (P < 0.0001, McNemar's chi super(2) test), especially in women with AZT/3TC > 3TC. The study demonstrates that transplacental NRTI exposures induce similar mitochondrial damage in cord blood and umbilical cords taken from retroviral-uninfected monkey infants and from human infants born to HIV-1-infected women. JF - Environmental and Molecular Mutagenesis AU - Divi, Rao L AU - Leonard, Sarah L AU - Kuo, Maryanne M AU - Nagashima, Kunio AU - Thamire, Chandrasekhar AU - Claire, Marisa C St AU - Wade, Nancy A AU - Walker, Vernon E AU - Poirier, Miriam C AD - Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, poirierm@exchange.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 201 EP - 209 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 48 IS - 3-4 SN - 0893-6692, 0893-6692 KW - Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Stavudine KW - Immunodeficiency KW - Lamivudine KW - Mitochondria KW - Zidovudine KW - Umbilical cord KW - Disease transmission KW - Mutagenesis KW - Endothelial cells KW - Cord blood KW - Dams KW - Human immunodeficiency virus 1 KW - Gestation KW - RNA-directed DNA polymerase KW - Electron microscopy KW - Combivir KW - Leukocytes KW - Toxicity KW - Children KW - Fetuses KW - Pregnancy KW - Birth KW - Mitochondrial DNA KW - Didanosine KW - Human immunodeficiency virus KW - Erythrocebus patas KW - Neonates KW - nucleoside reverse transcriptase inhibitors KW - Infants KW - V 22360:AIDS and HIV KW - X 24310:Pharmaceuticals KW - N 14835:Protein-Nucleic Acids Association UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19874498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Transplacentally+exposed+human+and+monkey+newborn+infants+show+similar+evidence+of+nucleoside+reverse+transcriptase+inhibitor-induced+mitochondrial+toxicity&rft.au=Divi%2C+Rao+L%3BLeonard%2C+Sarah+L%3BKuo%2C+Maryanne+M%3BNagashima%2C+Kunio%3BThamire%2C+Chandrasekhar%3BClaire%2C+Marisa+C+St%3BWade%2C+Nancy+A%3BWalker%2C+Vernon+E%3BPoirier%2C+Miriam+C&rft.aulast=Divi&rft.aufirst=Rao&rft.date=2007-05-01&rft.volume=48&rft.issue=3-4&rft.spage=201&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.20201 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Stavudine; Immunodeficiency; Zidovudine; Mitochondria; Lamivudine; Umbilical cord; Mutagenesis; Disease transmission; Cord blood; Endothelial cells; Dams; Gestation; RNA-directed DNA polymerase; Electron microscopy; Combivir; Leukocytes; Toxicity; Children; Fetuses; Pregnancy; Birth; Mitochondrial DNA; Didanosine; Neonates; Infants; nucleoside reverse transcriptase inhibitors; Human immunodeficiency virus; Human immunodeficiency virus 1; Erythrocebus patas DO - http://dx.doi.org/10.1002/em.20201 ER - TY - JOUR T1 - Use of dual affinity tags for expression and purification of functional peripheral cannabinoid receptor AN - 19802674; 8601552 AB - The human peripheral cannabinoid receptor (CB2) was expressed as a fusion with the maltose-binding protein (at the N-terminus), thioredoxin A (at the C-terminus) and two small affinity tags (a Strep-tag and a polyhistidine tag). Expression levels of the recombinant receptor in Escherichia coli BL21(DE3) cells were dependent on location and type of tags in the expression construct, and were as high as 1-2 mg per liter of bacterial culture. The recombinant receptor was ligand binding-competent, and activated cognate G- proteins in an in vitro coupled assay. The fusion CB2-125 protein was purified by immobilized metal affinity chromatography on a Ni-NTA resin. Maltose-binding protein, thioredoxin and a decahistidine tag were removed from the fusion by treatment with Tobacco etch virus (Tev) protease. Purification to over 90% homogeneity of the resulting CB2, containing an N- terminal Strep-tag was achieved by affinity chromatography on a StrepTactin resin. Circular dichroism spectroscopy indicated an alpha -helical content of the purified recombinant protein of [not, vert, similar]54%. The expression and purification protocol allows for production of large (milligram) quantities of functional peripheral cannabinoid receptor, suitable for subsequent structural characterization. Preliminary results of reconstitution experiments indicate that the CB2 has retained its ligand-binding properties. JF - Protein Expression and Purification AU - Yeliseev, Alexei AU - Zoubak, Lioudmila AU - Gawrisch, Klaus AD - Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, MD 20892, USA, yeliseeva@mail.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 153 EP - 163 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 53 IS - 1 SN - 1046-5928, 1046-5928 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Peripheral cannabinoid receptor KW - CB2 KW - Affinity tags KW - Chromatographic purification KW - Reconstitution KW - Functional KW - Heterologous expression KW - Thioredoxin KW - Metals KW - Resins KW - C-Terminus KW - Cell culture KW - protein purification KW - Spectroscopy KW - polyhistidine KW - N-Terminus KW - Affinity chromatography KW - Cannabinoid CB2 receptors KW - C.D. KW - Escherichia coli KW - Tobacco etch virus KW - Proteinase KW - Fusion protein KW - maltose-binding protein KW - V 22310:Genetics, Taxonomy & Structure KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19802674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Expression+and+Purification&rft.atitle=Use+of+dual+affinity+tags+for+expression+and+purification+of+functional+peripheral+cannabinoid+receptor&rft.au=Yeliseev%2C+Alexei%3BZoubak%2C+Lioudmila%3BGawrisch%2C+Klaus&rft.aulast=Yeliseev&rft.aufirst=Alexei&rft.date=2007-05-01&rft.volume=53&rft.issue=1&rft.spage=153&rft.isbn=&rft.btitle=&rft.title=Protein+Expression+and+Purification&rft.issn=10465928&rft_id=info:doi/10.1016%2Fj.pep.2006.12.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Thioredoxin; Metals; Resins; C-Terminus; Cell culture; protein purification; Spectroscopy; polyhistidine; N-Terminus; Affinity chromatography; C.D.; Cannabinoid CB2 receptors; Proteinase; Fusion protein; maltose-binding protein; Escherichia coli; Tobacco etch virus DO - http://dx.doi.org/10.1016/j.pep.2006.12.003 ER - TY - JOUR T1 - Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis AN - 19781321; 7419034 AB - The chromosomal instability syndromes Nijmegen breakage syndrome (NBS) and ataxia telangiectasia (AT) share many overlapping phenotypes, including cancer predisposition, radiation sensitivity, cell-cycle checkpoint defects, immunodeficiency, and gonadal dysfunction. The NBS protein Nbs1 is not only a downstream target of AT mutated (ATM) kinase but also acts upstream, promoting optimal ATM activation, ATM recruitment to breaks, and ATM accessibility to substrates. By reconstituting Nbs1 knockout mice with bacterial artificial chromosomes, we have assessed the contribution of distinct regions of Nbs1 to the ATM-dependent DNA damage response. We find that T cell and oocyte development, as well as DNA damage-induced G2/M and S phase checkpoint arrest and radiation survival are dependent on the N-terminal forkhead-associated domain, but not on the principal residues phosphorylated by ATM (S278 and S343) or on the evolutionarily conserved C-terminal region of Nbs1. However, the C-terminal region regulates irradiation-induced apoptosis. These studies provide insight into the complex interplay between Nbs1 and ATM in the DNA damage response. JF - Journal of Experimental Medicine AU - Difilippantonio, Simone AU - Celeste, Arkady AU - Kruhlak, Michael J AU - Lee, Youngsoo AU - Difilippantonio, Michael J AU - Feigenbaum, Lionel AU - Jackson, Stephen P AU - McKinnon, Peter J AU - Nussenzweig, Andre AD - Experimental Immunology Branch and Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN 38105. SAIC-Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick MD 21702. Wellcome Trust/Cancer Research U.K. Gurdon Institute and the Department of Zoology, University of Cambridge, Cambridge CB2 1QN, England, UK Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 1003 EP - 1011 PB - Rockefeller University Press, 1114 First Avenue New York NY 10021-8325 USA, [mailto:Bruce.Lyons@rockefeller.edu], [URL:http://www.rockefeller.edu/rupress] VL - 204 IS - 5 SN - 0022-1007, 0022-1007 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts KW - Cell survival KW - Nijmegen breakage syndrome KW - Apoptosis KW - Immunodeficiency KW - Cancer KW - Bacterial artificial chromosomes KW - DNA damage KW - Ataxia telangiectasia mutated protein KW - Genomic instability KW - S phase KW - Lymphocytes T KW - Oocytes KW - Evolution KW - N 14820:DNA Metabolism & Structure KW - J 02350:Immunology KW - F 06960:Molecular Immunology KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19781321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Medicine&rft.atitle=Distinct+domains+in+Nbs1+regulate+irradiation-induced+checkpoints+and+apoptosis&rft.au=Difilippantonio%2C+Simone%3BCeleste%2C+Arkady%3BKruhlak%2C+Michael+J%3BLee%2C+Youngsoo%3BDifilippantonio%2C+Michael+J%3BFeigenbaum%2C+Lionel%3BJackson%2C+Stephen+P%3BMcKinnon%2C+Peter+J%3BNussenzweig%2C+Andre&rft.aulast=Difilippantonio&rft.aufirst=Simone&rft.date=2007-05-01&rft.volume=204&rft.issue=5&rft.spage=1003&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Medicine&rft.issn=00221007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell survival; Nijmegen breakage syndrome; Apoptosis; Immunodeficiency; Cancer; Bacterial artificial chromosomes; Ataxia telangiectasia mutated protein; DNA damage; Genomic instability; S phase; Lymphocytes T; Oocytes; Evolution ER - TY - JOUR T1 - Coupling between allosteric transitions in GroEL and assisted folding of a substrate protein AN - 19776615; 7421310 AB - Escherichia coli chaperonin, GroEL, helps proteins fold under nonpermissive conditions. During the reaction cycle, GroEL undergoes allosteric transitions in response to binding of a substrate protein (SP), ATP, and the cochaperonin GroES. Using coarse-grained representations of the GroEL and GroES structures, we explore the link between allosteric transitions and the folding of a model SP, a de novo-designed four-helix bundle protein, with low spontaneous yield. The ensemble of GroEL-bound SP is less structured than the bulk misfolded structures. Upon binding, which kinetically occurs in two stages, the SP loses not only native tertiary contacts but also experiences a decrease in helical content. During multivalent binding and the subsequent ATP-driven transition of GroEL the SP undergoes force-induced stretching. Upon encapsulation, which occurs upon GroES binding, the SP finds itself in a "hydrophilic" cavity in which it can reach the folded conformation. Surprisingly, we find that the yield of the native state in the expanded GroEL cavity is relatively small even after it remains in it for twice the spontaneous folding time. Thus, in accord with the iterative annealing mechanism, multiple rounds of binding, partial unfolding, and release of the SP are required to enhance the yield of the folded SP. JF - Proceedings of the National Academy of Sciences, USA AU - Stan, George AU - Lorimer, George H AU - Thirumalai, D AU - Brooks, Bernard R AD - Laboratory of Computational Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 8803 EP - 8808 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 21 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology KW - Cavities KW - Protein folding KW - Allosteric properties KW - Chaperonins KW - Escherichia coli KW - ATP KW - Substance P KW - Encapsulation KW - Models KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19776615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Coupling+between+allosteric+transitions+in+GroEL+and+assisted+folding+of+a+substrate+protein&rft.au=Stan%2C+George%3BLorimer%2C+George+H%3BThirumalai%2C+D%3BBrooks%2C+Bernard+R&rft.aulast=Stan&rft.aufirst=George&rft.date=2007-05-01&rft.volume=104&rft.issue=21&rft.spage=8803&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cavities; Protein folding; Allosteric properties; Chaperonins; ATP; Substance P; Models; Encapsulation; Escherichia coli ER - TY - JOUR T1 - Effect of Plasmid DNA Vaccine Design and In Vivo Electroporation on the Resulting Vaccine-Specific Immune Responses in Rhesus Macaques AN - 19747668; 7408292 AB - Since human immunodeficiency virus (HIV)-specific cell-mediated immune (CMI) responses are critical in the early control and resolution of HIV infection and correlate with postchallenge outcomes in rhesus macaque challenge experiments, we sought to identify a plasmid DNA (pDNA) vaccine design capable of eliciting robust and balanced CMI responses to multiple HIV type 1 (HIV-1)-derived antigens for further development. Previously, a number of two-, three-, and four-vector pDNA vaccine designs were identified as capable of eliciting HIV-1 antigen-specific CMI responses in mice (M. A. Egan et al., Vaccine 24:4510-4523, 2006). We then sought to further characterize the relative immunogenicities of these two-, three-, and four-vector pDNA vaccine designs in nonhuman primates and to determine the extent to which in vivo electroporation (EP) could improve the resulting immune responses. The results indicated that a two-vector pDNA vaccine design elicited the most robust and balanced CMI response. In addition, vaccination in combination with in vivo EP led to a more rapid onset and enhanced vaccine-specific immune responses. In macaques immunized in combination with in vivo EP, we observed a 10- to 40-fold increase in HIV-specific enzyme-linked immunospot assay responses compared to those for macaques receiving a 5-fold higher dose of vaccine without in vivo EP. This increase in CMI responses translates to an apparent 50- to 200-fold increase in pDNA vaccine potency. Importantly, in vivo EP enhanced the immune response against the less immunogenic antigens, resulting in a more balanced immune response. In addition, in vivo EP resulted in an approximate 2.5-log sub(10) increase in antibody responses. The results further indicated that in vivo EP was associated with a significant reduction in pDNA persistence and did not result in an increase in pDNA associated with high-molecular-weight DNA relative to macaques receiving the pDNA without EP. Collectively, these results have important implications for the design and development of an efficacious vaccine for the prevention of HIV-1 infection. JF - Journal of Virology AU - Luckay, Amara AU - Sidhu, Maninder K AU - Kjeken, Rune AU - Megati, Shakuntala AU - Chong, Siew-Yen AU - Roopchand, Vidia AU - Garcia-Hand, Dorys AU - Abdullah, Rashed AU - Braun, Ralph AU - Montefiori, David C AU - Rosati, Margherita AU - Felber, Barbara K AU - Pavlakis, George N AU - Mathiesen, Iacob AU - Israel, Zimra R AU - Eldridge, John H AU - Egan, Michael A AD - Wyeth Vaccines Research, Pearl River, New York 10965. Inovio AS, Forskningsveien 2a, 0373, Oslo, Norway. Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710. Human Retrovirus Section. Human Retrovirus Pathogenesis Section, National Cancer Institute-Frederick, Frederick, Maryland 21702-1201 Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 5257 EP - 5269 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 81 IS - 10 SN - 0022-538X, 0022-538X KW - Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Enzyme-linked immunosorbent assay KW - Electroporation KW - Macaca KW - Plasmids KW - Infection KW - Primates KW - Vaccination KW - Antibodies KW - DNA vaccines KW - Immunogenicity KW - Human immunodeficiency virus 1 KW - Macaca mulatta KW - Immune response KW - Vaccines KW - V 22360:AIDS and HIV KW - N 14845:Miscellaneous KW - W 30915:Pharmaceuticals & Vaccines KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19747668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Effect+of+Plasmid+DNA+Vaccine+Design+and+In+Vivo+Electroporation+on+the+Resulting+Vaccine-Specific+Immune+Responses+in+Rhesus+Macaques&rft.au=Luckay%2C+Amara%3BSidhu%2C+Maninder+K%3BKjeken%2C+Rune%3BMegati%2C+Shakuntala%3BChong%2C+Siew-Yen%3BRoopchand%2C+Vidia%3BGarcia-Hand%2C+Dorys%3BAbdullah%2C+Rashed%3BBraun%2C+Ralph%3BMontefiori%2C+David+C%3BRosati%2C+Margherita%3BFelber%2C+Barbara+K%3BPavlakis%2C+George+N%3BMathiesen%2C+Iacob%3BIsrael%2C+Zimra+R%3BEldridge%2C+John+H%3BEgan%2C+Michael+A&rft.aulast=Luckay&rft.aufirst=Amara&rft.date=2007-05-01&rft.volume=81&rft.issue=10&rft.spage=5257&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Antibodies; Enzyme-linked immunosorbent assay; Electroporation; DNA vaccines; Immunogenicity; Vaccines; Immune response; Infection; Plasmids; Vaccination; Macaca; Human immunodeficiency virus 1; Macaca mulatta; Primates ER - TY - JOUR T1 - Phase I clinical evaluation of a six-plasmid multiclade HIV-1 DNA candidate vaccine AN - 19740793; 7640728 AB - Needle-free delivery of a six-plasmid HIV-1 DNA vaccine encoding EnvA, EnvB, EnvC, and subtype B Gag, Pol, and Nef underwent open-label evaluation in 15 subjects; 14 completed the 0, 1, 2 month vaccination schedule. T cell responses to HIV-specific peptide pools were detected by intracellular cytokine staining of CD4+ [13/14 (93%)] and CD8+ [5/14 (36%)], and by ELISpot in 11/14 (79%). Ten of 14 (71%) had ELISA antibody responses to Env proteins. Compared to a four-plasmid product, Gag- and Nef-specific T cell responses were improved, while Env-specific responses were maintained. This candidate vaccine has now advanced to Phase II evaluation. JF - Vaccine AU - Catanzaro, Andrew T AU - Roederer, Mario AU - Koup, Richard A AU - Bailer, Robert T AU - Enama, Mary E AU - Nason, Martha C AU - Martin, Julie E AU - Rucker, Steve AU - Andrews, Charla A AU - Gomez, Phillip L AU - Mascola, John R AU - Nabel, Gary J AU - Graham, Barney S AD - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Building 40, Bethesda, MD 20892-3017, United States, bgraham@nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 4085 EP - 4092 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 25 IS - 20 SN - 0264-410X, 0264-410X KW - Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Promoter KW - T cell response KW - AIDS KW - Prevention KW - Envelope KW - Gag KW - Pol KW - Nef KW - Enzyme-linked immunosorbent assay KW - Antibodies KW - CD4 antigen KW - DNA vaccines KW - Human immunodeficiency virus 1 KW - Envelope protein KW - Lymphocytes T KW - Cytokines KW - CD8 antigen KW - Nef protein KW - Vaccination KW - V 22360:AIDS and HIV KW - F 06905:Vaccines KW - W 30915:Pharmaceuticals & Vaccines KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19740793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Phase+I+clinical+evaluation+of+a+six-plasmid+multiclade+HIV-1+DNA+candidate+vaccine&rft.au=Catanzaro%2C+Andrew+T%3BRoederer%2C+Mario%3BKoup%2C+Richard+A%3BBailer%2C+Robert+T%3BEnama%2C+Mary+E%3BNason%2C+Martha+C%3BMartin%2C+Julie+E%3BRucker%2C+Steve%3BAndrews%2C+Charla+A%3BGomez%2C+Phillip+L%3BMascola%2C+John+R%3BNabel%2C+Gary+J%3BGraham%2C+Barney+S&rft.aulast=Catanzaro&rft.aufirst=Andrew&rft.date=2007-05-01&rft.volume=25&rft.issue=20&rft.spage=4085&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2007.02.050 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - CD4 antigen; Antibodies; Enzyme-linked immunosorbent assay; DNA vaccines; Envelope protein; Lymphocytes T; Cytokines; CD8 antigen; Nef protein; Vaccination; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1016/j.vaccine.2007.02.050 ER - TY - JOUR T1 - Metagenomic sorcery and the expanding protein universe AN - 19720293; 7511183 AB - A metagenomic study of the Atlantic and Pacific oceans reveals dominant bacterial species, remarkable microdiversity and a wealth of new proteins. JF - Nature Biotechnology AU - Koonin, E V AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, Maryland 20894, USA, koonin@ncbi.nlm.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 540 EP - 542 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 25 IS - 5 SN - 1087-0156, 1087-0156 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; ASFA Marine Biotechnology Abstracts KW - Marine microorganisms KW - genomics KW - Diversity KW - J 02310:Genetics & Taxonomy KW - Q4 27760:Microorganisms KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19720293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=Metagenomic+sorcery+and+the+expanding+protein+universe&rft.au=Koonin%2C+E+V&rft.aulast=Koonin&rft.aufirst=E&rft.date=2007-05-01&rft.volume=25&rft.issue=5&rft.spage=540&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2Fnbt0507-540 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Marine microorganisms; genomics; Diversity DO - http://dx.doi.org/10.1038/nbt0507-540 ER - TY - JOUR T1 - How do patients evaluate and make use of online health information? AN - 19716738; 7496402 AB - Increasing numbers of people are turning to the Internet for health advice despite reports that sites vary in terms of their quality. How do they decide whether or not to trust the advice they find online? A staged model of trust development is proposed and tested here in a longitudinal study in which fifteen women faced with decisions concerning the menopause and hormone replacement therapy (HRT) were observed while searching the Internet for information and advice over four consecutive weeks and then kept diaries over a six-month follow-up period. The women were all resident in the North-East of England and were recruited through advertisements in the local media. The study provided general support for a three-stage model of trust in which participants firstly engaged in rapid heuristic processing of information, efficiently sifting and rejecting general sales sites and portals but sometimes rejecting high-quality content because of poor design. Well-designed sites were then effectively interrogated for credible and personalized content before being designated trustworthy. The women appeared to act much like 'scientists' using web material to generate and test hypotheses and theories about HRT, although their capacity to deal with certain forms of risk information was limited. They subsequently reported integrating online advice with offline advice from friends, family and physicians in order to be fully confident in their final decisions. Women felt that the Internet influenced their decision-making and improved communications with physicians. Personalized stories from like-minded others improved trust perceptions. Despite the use of the Internet the physician was still seen as the primary source of information and advice. JF - Social Science and Medicine AU - Sillence, E AU - Briggs, P AU - Harris, PR AU - Fishwick, L AD - Northumbria University, Newcastle upon Tyne, NEI 8ST, UK, elizabeth.sillence@unn.ac.uk Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 1853 EP - 1862 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 64 IS - 9 SN - 0277-9536, 0277-9536 KW - Risk Abstracts KW - Data collection KW - Communications KW - British Isles, England KW - Health care KW - Perception KW - Quality control KW - menopause KW - Information technology KW - Internet KW - longitudinal studies KW - hormone replacement therapy KW - R2 23020:Technological risks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19716738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+and+Medicine&rft.atitle=How+do+patients+evaluate+and+make+use+of+online+health+information%3F&rft.au=Sillence%2C+E%3BBriggs%2C+P%3BHarris%2C+PR%3BFishwick%2C+L&rft.aulast=Sillence&rft.aufirst=E&rft.date=2007-05-01&rft.volume=64&rft.issue=9&rft.spage=1853&rft.isbn=&rft.btitle=&rft.title=Social+Science+and+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2007.01.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Data collection; Communications; Health care; Perception; Quality control; menopause; Information technology; hormone replacement therapy; longitudinal studies; Internet; British Isles, England DO - http://dx.doi.org/10.1016/j.socscimed.2007.01.012 ER - TY - JOUR T1 - Radiolabeled high affinity peptidomimetic antagonist selectively targets alpha sub(v) beta sub(3) receptor-positive tumor in mice AN - 19694086; 7480594 AB - Objectives: The aim of this research was to synthesize radiolabeled peptidomimetic integrin alpha sub(v) beta sub(3) antagonists that selectively target integrin alpha sub(v) beta sub(3) receptor and clear rapidly from the whole body. Methods: Integrin alpha sub(v) beta sub(3) antagonists, 4-[2-(3,4,5,6-tetrahydropyrimidme-2-ylamino) emyloxy]benzoyl-2-(S)-aminoemylsulfonyl-amino- beta -alanine (IA) and 4-[2-(3,4,5,6-tetraydro-pyrimidin-2-ylammo) -ethyloxy]benzoyl-2-(S)-[N-(3-amino-neopenta-1-carbamyl)] -aminoethylsulfonylamino- beta -alanine hydrochloride (IAC), a hydrophobic carbamate derivative of IA, were conjugated with 2-p-isothiocyanatobenzyl-DOTA at the amino terminus and labeled with super(111)In. The super(111)In labeled IA and IAC were subjected to in vitro receptor binding, biodistribution and imaging studies using nude mice bearing the receptor-positive M21 human melanoma xenografts. Results: The super(111)In-labeled IA (40%) and -IAC (72%) specifically bound in vitro to alpha sub(v) beta sub(3) (0.8 mu M) at a molar excess. This receptor binding was completely blocked by a molar excess of cold IA to alpha sub(v) beta sub(3). The higher receptor-binding affinity of the super(111)In-labeled IAC was reflected in higher tumor uptake and retention: 5.6 plus or minus 1.4 and 4.5 plus or minus 0.7% ID/g vs. 3.8 plus or minus 0.9 and 2.0 plus or minus 0.3% ID/g for the super(111)In-labeled IA at 0.33 and 2 h. The tumor uptakes were inhibited by the co-injection of 200 mu g of IA, indicating that the uptake was receptor mediated. These antagonists were excreted primarily via the renal system. The super(111)In activity retained in the whole body was quite comparable between the super(111)In-labeled IA (24% ID) and the super(111)in-labeled IAC (33% ID) at 2 h. The higher peak tumor uptake and longer retention resulted in higher tumor-to-background ratios for the super(111)In-labeled IAC at 2 h with 9.7, 2.3, 0.8, 1.9, 7.1, 2.2, 0.9, 3.7 and 9.9 for blood, liver, kidney, lung, heart, stomach, intestine, bone and muscle, respectively. The imaging studies with the super(111)In-labeled IAC also clearly visualized the receptor-positive tumor at 4 h. Conclusions: The super(111)in-labeled IAC showed an improve tumor targeting kinetics with rapid accumulation and prolonged retention in the alpha sub(v) beta sub(3) receptor-positive tumor. This together with the rapid whole-body clearance pharmacokinetics warrants further studies on this IAC analog for molecular imaging of tumor-induced angiogenic vessels and various malignant human tumors expressing the receptor. JF - Nuclear Medicine and Biology AU - Jang, B-S AU - Lim, E AU - Park, SH AU - Shin, I S AU - Danthi, S N AU - Hwang, I S AU - Le, N AU - Yu, S AU - Xie, J AU - Li, KCP AU - Carrasquillo, JA AU - Paik, CH AD - Department of Nuclear Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA, cpaik@mail.nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 363 EP - 370 VL - 34 IS - 4 SN - 0969-8051, 0969-8051 KW - Biotechnology and Bioengineering Abstracts KW - Teeth KW - Molars KW - peptidomimetics KW - Muscles KW - Angiogenesis KW - Cardiac muscle KW - Hydrophobicity KW - Tumors KW - imaging KW - Pharmacokinetics KW - Melanoma KW - Blood KW - Lung KW - Integrins KW - Kinetics KW - Intestine KW - Liver KW - Kidney KW - Xenografts KW - Stomach KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19694086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+Medicine+and+Biology&rft.atitle=Radiolabeled+high+affinity+peptidomimetic+antagonist+selectively+targets+alpha+sub%28v%29+beta+sub%283%29+receptor-positive+tumor+in+mice&rft.au=Jang%2C+B-S%3BLim%2C+E%3BPark%2C+SH%3BShin%2C+I+S%3BDanthi%2C+S+N%3BHwang%2C+I+S%3BLe%2C+N%3BYu%2C+S%3BXie%2C+J%3BLi%2C+KCP%3BCarrasquillo%2C+JA%3BPaik%2C+CH&rft.aulast=Jang&rft.aufirst=B-S&rft.date=2007-05-01&rft.volume=34&rft.issue=4&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=Nuclear+Medicine+and+Biology&rft.issn=09698051&rft_id=info:doi/10.1016%2Fj.nucmedbio.2007.02.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Tumors; imaging; Integrins; Teeth; Kidney; peptidomimetics; Molars; Angiogenesis; Hydrophobicity; Cardiac muscle; Lung; Melanoma; Kinetics; Xenografts; Pharmacokinetics; Liver; Stomach; Muscles; Blood; Intestine DO - http://dx.doi.org/10.1016/j.nucmedbio.2007.02.002 ER - TY - JOUR T1 - Pulsed-High Intensity Focused Ultrasound and Low Temperature-Sensitive Liposomes for Enhanced Targeted Drug Delivery and Antitumor Effect AN - 19677601; 7417231 AB - PURPOSE: To determine if pulsed-high intensity focused ultrasound (HIFU) could effectively serve as a source of hyperthermia with thermosensitive liposomes to enhance delivery and efficacy of doxorubicin in tumors. Experimental Design: Comparisons in vitro and in vivo were carried out between non-thermosensitive liposomes (NTSL) and low temperature-sensitive liposomes (LTSL). Liposomes were incubated in vitro over a range of temperatures and durations, and the amount of doxorubicin released was measured. For in vivo experiments, liposomes and free doxorubicin were injected i.v. in mice followed by pulsed-HIFU exposures in s.c. murine adenocarcinoma tumors at 0 and 24 h after administration. Combinations of the exposures and drug formulations were evaluated for doxorubicin concentration and growth inhibition in the tumors. RESULTS: In vitro incubations simulating the pulsed-HIFU thermal dose (42^'C for 2 min) triggered release of 50% of doxorubicin from the LTSLs; however, no detectable release from the NTSLs was observed. Similarly, in vivo experiments showed that pulsed-HIFU exposures combined with the LTSLs resulted in more rapid delivery of doxorubicin as well as significantly higher i.t. concentration when compared with LTSLs alone or NTSLs, with or without exposures. Combining the exposures with the LTSLs also significantly reduced tumor growth compared with all other groups. CONCLUSIONS: Combining low-temperature heat-sensitive liposomes with noninvasive and nondestructive pulsed-HIFU exposures enhanced the delivery of doxorubicin and, consequently, its antitumor effects. This combination therapy could potentially produce viable clinical strategies for improved targeting and delivery of drugs for treatment of cancer and other diseases. JF - Clinical Cancer Research AU - Dromi, Sergio AU - Frenkel, Victor AU - Luk, Alfred AU - Traughber, Bryan AU - Angstadt, Mary AU - Bur, Monica AU - Poff, Jason AU - Xie, Jianwu AU - Libutti, Steven K AU - Li, King CP AU - Wood, Bradford J AD - Authors' Affiliations: Diagnostic Radiology Department, Clinical Center and Tumor Angiogenesis Section, Surgery Branch, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2007/05/01/ PY - 2007 DA - 2007 May 01 SP - 2722 EP - 2727 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 13 IS - 9 SN - 1078-0432, 1078-0432 KW - Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Drug delivery KW - Hyperthermia KW - Drug development KW - Tumors KW - Adenocarcinoma KW - Ultrasound KW - Liposomes KW - Doxorubicin KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19677601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Pulsed-High+Intensity+Focused+Ultrasound+and+Low+Temperature-Sensitive+Liposomes+for+Enhanced+Targeted+Drug+Delivery+and+Antitumor+Effect&rft.au=Dromi%2C+Sergio%3BFrenkel%2C+Victor%3BLuk%2C+Alfred%3BTraughber%2C+Bryan%3BAngstadt%2C+Mary%3BBur%2C+Monica%3BPoff%2C+Jason%3BXie%2C+Jianwu%3BLibutti%2C+Steven+K%3BLi%2C+King+CP%3BWood%2C+Bradford+J&rft.aulast=Dromi&rft.aufirst=Sergio&rft.date=2007-05-01&rft.volume=13&rft.issue=9&rft.spage=2722&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Liposomes; Doxorubicin; Tumors; Ultrasound; Drug delivery; Adenocarcinoma; Drug development; Temperature effects; Hyperthermia ER - TY - JOUR T1 - The Flame Retardants, Polybrominated Diphenyl Ethers, Are Pregnane X Receptor Activators AN - 19670635; 7421935 AB - Polybrominated diphenyl ethers (PBDEs) are used as flame retardants and are universally present in the environment. An exponential increase in PBDE concentrations in the U.S. population have been reported over the last 3 decades. PBDEs 47 (tetraBDE) and 99 (pentaBDE) are the most commonly detected PBDE congeners in the environment and in human samples. PBDE209 (decaBDE) is the only remaining PBDE flame retardant commercially manufactured in the United States. Several PBDEs are known to induce cyp3a in rats, but the mechanism of induction remains unclear. The goal of this study was to clarify the mechanism by which PBDE congeners induce cyp3a. Treatment of C57BL6 mice with PBDEs 47, 99, and 209 induced gene expressions of cyp3a11 and 2b10, but not cyp1a1/2. Because the first two genes are known target genes of pregnane X receptor (PXR), a ligand-activated transcription factor in the nuclear hormone receptor superfamily, we hypothesized that PBDE congeners are PXR activators. Using reporter gene luciferase assays, the present data show that PBDEs 47, 99, and 209 activated PXR and its human counterpart, steroid X receptor, but not aryl hydrocarbon receptor. Furthermore, induction of cyp3a11 and 2b10 by PBDEs 47, 99, and 209 was markedly suppressed in PXR-knockout mice, indicating that PBDE congeners activate PXR in vivo. In summary, our study provides the first evidence that PBDEs are activators for xenobiotic nuclear receptor. JF - Toxicological Sciences AU - Pacyniak, Erik K AU - Cheng, Xingguo AU - Cunningham, Michael L AU - Crofton, Kevin AU - Klaassen, Curtis D AU - Guo, Grace L AD - Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160. National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Environment Protection Agency, Research Triangle Park, North Carolina 27709 Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 94 EP - 102 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 97 IS - 1 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - Gene expression KW - polybrominated diphenyl ethers KW - Reporter gene KW - Nuclear receptors KW - Transcription factors KW - Congeners KW - Fire retardant chemicals KW - pregnane X receptors KW - Cytochrome P450 KW - Steroid hormones KW - Aryl hydrocarbon receptors KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19670635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=The+Flame+Retardants%2C+Polybrominated+Diphenyl+Ethers%2C+Are+Pregnane+X+Receptor+Activators&rft.au=Pacyniak%2C+Erik+K%3BCheng%2C+Xingguo%3BCunningham%2C+Michael+L%3BCrofton%2C+Kevin%3BKlaassen%2C+Curtis+D%3BGuo%2C+Grace+L&rft.aulast=Pacyniak&rft.aufirst=Erik&rft.date=2007-05-01&rft.volume=97&rft.issue=1&rft.spage=94&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gene expression; polybrominated diphenyl ethers; Reporter gene; Transcription factors; Nuclear receptors; Congeners; Steroid hormones; Cytochrome P450; pregnane X receptors; Fire retardant chemicals; Aryl hydrocarbon receptors ER - TY - JOUR T1 - Quantitation of HIV-1 RNA levels in plasma and CSF of asymptomatic HIV-1 infected patients from South India using a TaqMan real time PCR assay AN - 19668895; 7430577 AB - Background: Most of the quantitation assays for HIV-1 RNA used currently are designed and optimized for HIV-1 subtype B viruses and hence may not be suitable for India, where the predominant subtype is HIV-1 subtype C. Objectives: Development and standardization of HIV-1 TaqMan real time PCR assay suitable for measuring plasma and CSF viral RNA levels in HIV subtype C infected individuals. Study design: A TaqMan real time PCR was developed using primers and probes selected in the gag region for detection of Indian HIV-1 subtype C strain. Plasma (n=120) and CSF samples (n=46) obtained from HIV infected subjects were used to evaluate the sensitivity and specificity of the assay. A comparative evaluation was carried out with a commercially available quantitative HIV viral load assay (Roche Amplicor Version 1.5). Results: The TaqMan assay was able to amplify all HIV-1 group M subtypes except subtype E. Viral loads could be estimated in all the plasma (n=120) and 40/46 CSF samples obtained from HIV positive subjects. Sensitivity of this assay was found to be 180copies/ml. Correlation with the commercially available viral load assay was very good (r=0.885). Conclusions: A TaqMan real time PCR was standardized for HIV-1 subtype C and it was more sensitive (180copies/ml) than standard Amplicor monitor assay, Version 1.5 (400copies/ml). JF - Journal of Clinical Virology AU - Kamat, A AU - Ravi, V AU - Desai, A AU - Satishchandra, P AU - Satish, K S AU - Borodowsky, I AU - Subbakrishna, D K AU - Kumar, M AD - National Institute of Mental Health and Neuro Sciences, Bangalore 560029, India, vravi@nimhans.kar.nic.in Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 9 EP - 15 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 39 IS - 1 SN - 1386-6532, 1386-6532 KW - HIV-1 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Standardization KW - India, South KW - RNA KW - Colony-stimulating factor KW - DNA probes KW - Human immunodeficiency virus 1 KW - Polymerase chain reaction KW - Quantitation KW - Gag protein KW - V 22360:AIDS and HIV KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19668895?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Virology&rft.atitle=Quantitation+of+HIV-1+RNA+levels+in+plasma+and+CSF+of+asymptomatic+HIV-1+infected+patients+from+South+India+using+a+TaqMan+real+time+PCR+assay&rft.au=Kamat%2C+A%3BRavi%2C+V%3BDesai%2C+A%3BSatishchandra%2C+P%3BSatish%2C+K+S%3BBorodowsky%2C+I%3BSubbakrishna%2C+D+K%3BKumar%2C+M&rft.aulast=Kamat&rft.aufirst=A&rft.date=2007-05-01&rft.volume=39&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Virology&rft.issn=13866532&rft_id=info:doi/10.1016%2Fj.jcv.2006.12.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Standardization; RNA; Colony-stimulating factor; DNA probes; Polymerase chain reaction; Quantitation; Gag protein; Human immunodeficiency virus 1; India, South DO - http://dx.doi.org/10.1016/j.jcv.2006.12.026 ER - TY - JOUR T1 - Regulation of AID expression in the immune response AN - 19666552; 7419046 AB - The B cell-specific enzyme activation-induced cytidine deaminase (AID) has been shown to be essential for isotype switching and affinity maturation of antibody genes during the immune response. Conversely, AID activity has also been linked to autoimmunity and tumorigenesis. Determining how AID expression is regulated in vivo is therefore central to understanding its role in health and disease. Here we use phylogenetic footprinting and high-resolution histone acetylation mapping to accurately demarcate AID gene regulatory boundaries. Based on this strategy, we identify a novel, positive regulatory element required for AID transcription. Furthermore, we generate two AID indicator mouse strains using bacterial artificial chromosomes that faithfully recapitulate endogenous AID expression. The first strain uses a green fluorescent protein reporter to identify B cells that actively express AID during the immune response. In the second strain, AID transcription affects the permanent expression of a yellow fluorescent protein reporter in post-germinal center and terminally differentiated lymphocytes. We demonstrate the usefulness of these novel strains by resolving recent contradictory observations on AID expression during B cell ontogeny. JF - Journal of Experimental Medicine AU - Crouch, Elizabeth E AU - Li, Zhiyu AU - Takizawa, Makiko AU - Fichtner-Feigl, Stefan AU - Gourzi, Polyxeni AU - Montano, Carolina AU - Feigenbaum, Lionel AU - Wilson, Patrick AU - Janz, Siegfried AU - Papavasiliou, FNina AU - Casellas, Rafael AD - Genomic Integrity and Immunity, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Mucosal Immunity Section, National Institute of Allergy and Infectious Diseases (NIAID), and Laboratory of Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD 20892. Laboratory of Lymphocyte Biology, The Rockefeller University, New York, NY 10021. Laboratory Animal Science Program, Science Applications International Corporation (SAIC), NCI, NIH, Frederick, MD 21702. Molecular Immunogenetics, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104 Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 1145 EP - 1156 PB - Rockefeller University Press, 1114 First Avenue New York NY 10021-8325 USA, [mailto:Bruce.Lyons@rockefeller.edu], [URL:http://www.rockefeller.edu/rupress] VL - 204 IS - 5 SN - 0022-1007, 0022-1007 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts KW - Phylogeny KW - Histones KW - Footprinting KW - Lymphocytes B KW - Regulatory sequences KW - Tumorigenesis KW - Class switching KW - Green fluorescent protein KW - Transcription KW - Autoimmunity KW - Enzymes KW - Activation-induced cytidine deaminase KW - Bacterial artificial chromosomes KW - Acetylation KW - Antibodies KW - yellow fluorescent protein KW - Boundaries KW - Ontogeny KW - Gene mapping KW - J 02350:Immunology KW - F 06960:Molecular Immunology KW - N 14825:Gene Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19666552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Medicine&rft.atitle=Regulation+of+AID+expression+in+the+immune+response&rft.au=Crouch%2C+Elizabeth+E%3BLi%2C+Zhiyu%3BTakizawa%2C+Makiko%3BFichtner-Feigl%2C+Stefan%3BGourzi%2C+Polyxeni%3BMontano%2C+Carolina%3BFeigenbaum%2C+Lionel%3BWilson%2C+Patrick%3BJanz%2C+Siegfried%3BPapavasiliou%2C+FNina%3BCasellas%2C+Rafael&rft.aulast=Crouch&rft.aufirst=Elizabeth&rft.date=2007-05-01&rft.volume=204&rft.issue=5&rft.spage=1145&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Medicine&rft.issn=00221007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Phylogeny; Histones; Footprinting; Lymphocytes B; Regulatory sequences; Class switching; Tumorigenesis; Green fluorescent protein; Enzymes; Autoimmunity; Transcription; Activation-induced cytidine deaminase; Bacterial artificial chromosomes; Acetylation; Antibodies; yellow fluorescent protein; Boundaries; Ontogeny; Gene mapping ER - TY - JOUR T1 - The Yersinia Effector Protein YpkA Induces Apoptosis Independently of Actin Depolymerization AN - 19666436; 7419213 AB - The pathogenicity of the plague agent Yersinia pestis is largely due to the injection of effector proteins that potently block immune responses into host cells through a type III secretion apparatus. One Yersinia effector protein, YpkA, a putative serine/threonine kinase, has been reported to act by depolymerizing actin and disrupting actin microfilament organization. Using YpkA-GFP fusion proteins to directly visualize cells expressing YpkA, we found instead that YpkA triggered rapid cell death that can be blocked by caspase inhibitors and Bcl-x sub(L), but was not dependent on caspase-8. The actin depolymerization promoted by YpkA was only seen in cells with other features of apoptosis, and was blocked by inhibiting apoptosis, indicating that actin filament disruption is likely to be a result, rather than a cause of YpkA-induced apoptosis. A region including aa 133-262 in YpkA was sufficient for inducing apoptosis independent of localization to the plasma membrane. These data suggest that YpkA can act as a direct inducer of cell death. JF - Journal of Immunology AU - Park, Heiyoung AU - Teja, Kabir AU - O'Shea, John J AU - Siegel, Richard M AD - Molecular Immunology and Inflammation Branch, and Immunoregulation Unit, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892 Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 6426 EP - 6434 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 178 IS - 10 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Microfilaments KW - Apoptosis KW - Protein-serine/threonine kinase KW - Depolymerization KW - Caspase-8 KW - Caspase inhibitors KW - Yersinia pestis KW - Bcl-x protein KW - Plasma membranes KW - Pathogenicity KW - Actin KW - Fusion protein KW - Plague KW - Filaments KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19666436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=The+Yersinia+Effector+Protein+YpkA+Induces+Apoptosis+Independently+of+Actin+Depolymerization&rft.au=Park%2C+Heiyoung%3BTeja%2C+Kabir%3BO%27Shea%2C+John+J%3BSiegel%2C+Richard+M&rft.aulast=Park&rft.aufirst=Heiyoung&rft.date=2007-05-01&rft.volume=178&rft.issue=10&rft.spage=6426&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Microfilaments; Apoptosis; Depolymerization; Protein-serine/threonine kinase; Caspase-8; Caspase inhibitors; Bcl-x protein; Pathogenicity; Plasma membranes; Actin; Plague; Fusion protein; Filaments; Yersinia pestis ER - TY - JOUR T1 - Pertussis Toxin by Inducing IL-6 Promotes the Generation of IL-17-Producing CD4 Cells AN - 19665536; 7419179 AB - Compelling evidence has now demonstrated that IL-17-producing CD4 cells (Th17) are a major contributor to autoimmune pathogenesis, whereas CD4 super(+)CD25 super(+) T regulatory cells (Treg) play a major role in suppression of autoimmunity. Differentiation of proinflammatory Th17 and immunosuppressive Treg from naive CD4 cells is reciprocally related and contingent upon the cytokine environment. We and others have reported that in vivo administration of pertussis toxin (PTx) reduces the number and function of mouse Treg. In this study, we have shown that supernatants from PTx-treated mouse splenic cells, which contained IL-6 and other proinflammatory cytokines, but not PTx itself, overcame the inhibition of proliferation seen in cocultures of Treg and CD4 super(+)CD25 super(-) T effector cells. This stimulatory effect could be mimicked by individual inflammatory cytokines such as IL-1 beta , IL-6, and TNF- alpha . The combination of these cytokines synergistically stimulated the proliferation of CD4 super(+)CD25 super(-) T effector cells despite the presence of Treg with a concomitant reduction in the percentage of FoxP3 super(+) cells and generation of IL-17-expressing cells. PTx generated Th17 cells, while inhibiting the differentiation of FoxP super(+) cells, from naive CD4 cells when cocultured with bone marrow-derived dendritic cells from wild-type mice, but not from IL-6 super(-/-) mice. In vivo treatment with PTx induced IL-17-secreting cells in wild-type mice, but not in IL-6 super(-/-) mice. Thus, in addition to inhibiting the development of Treg, the immunoadjuvant activity of PTx can be attributable to the generation of IL-6-dependent IL-17-producing CD4 cells. JF - Journal of Immunology AU - Chen, Xin AU - Howard, OMZack AU - Oppenheim, Joost J AD - Basic Research Program, SAIC-Frederick, National Cancer Institute-Frederick, Frederick, MD 21702. Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702 Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 6123 EP - 6129 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 178 IS - 10 SN - 0022-1767, 0022-1767 KW - Toxicology Abstracts; Immunology Abstracts KW - Interleukin 6 KW - Immunoregulation KW - Helper cells KW - Interleukin 1 KW - Autoimmune diseases KW - Bone marrow KW - Autoimmunity KW - Spleen KW - CD25 antigen KW - pertussis toxin KW - Effector cells KW - Inflammation KW - Dendritic cells KW - Differentiation KW - CD4 antigen KW - Foxp3 protein KW - Lymphocytes T KW - Tumor necrosis factor- alpha KW - Cell proliferation KW - X 24490:Other KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19665536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Pertussis+Toxin+by+Inducing+IL-6+Promotes+the+Generation+of+IL-17-Producing+CD4+Cells&rft.au=Chen%2C+Xin%3BHoward%2C+OMZack%3BOppenheim%2C+Joost+J&rft.aulast=Chen&rft.aufirst=Xin&rft.date=2007-05-01&rft.volume=178&rft.issue=10&rft.spage=6123&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Immunoregulation; Helper cells; Autoimmune diseases; Interleukin 1; Bone marrow; Spleen; Autoimmunity; CD25 antigen; Inflammation; Effector cells; pertussis toxin; Differentiation; Dendritic cells; CD4 antigen; Foxp3 protein; Lymphocytes T; Tumor necrosis factor- alpha; Cell proliferation ER - TY - JOUR T1 - Effective therapy of murine models of human leukemia and lymphoma with radiolabeled anti-CD30 antibody, HeFi-1 AN - 19664105; 7421266 AB - CD30 is a member of the TNF receptor superfamily. Overexpression of CD30 on some neoplasms versus limited expression on normal tissues makes this receptor a promising target for antibody-based therapy. Radioimmunotherapy of cancer with radiolabeled antibodies has shown promise. In this study, we evaluated the therapeutic efficacy of an anti-CD30 antibody, HeFi-1, armed with @@u211@At in a leukemia (karpas299) model and with @@u90@Y in a lymphoma (SUDHL-1) model. Furthermore, we investigated the combination therapy of @@u211@At-HeFi-1 with unmodified HeFi-1 in the leukemia model. Treatment with unmodified HeFi-1 significantly prolonged the survival of the karpas299-bearing mice compared with the controls (P < 0.001). Treatment with @@u211@At-HeFi-1 showed greater therapeutic efficacy than that with unmodified HeFi-1 as shown by survival of the mice (P < 0.001). Combining these two agents further improved the survival of the mice compared with the groups treated with either @@u211@At-HeFi-1 (P < 0.05) or unmodified HeFi-1 (P < 0.001) alone. In the lymphoma model, the survival of the SUDHL-1-bearing mice was significantly prolonged by the treatment with @@u90@Y-HeFi-1 compared with the controls (P < 0.001). In summary, radiolabeled HeFi-1 is very promising for the treatment of CD30-expressing leukemias and lymphomas, and the combination regimen of @@u211@At-HeFi-1 with unmodified HeFi-1 enhanced the therapeutic efficacy. JF - Proceedings of the National Academy of Sciences, USA AU - Zhang, Meili AU - Yao, Zhengsheng AU - Patel, Hiral AU - Garmestani, Kayhan AU - Zhang, Zhuo AU - Talanov, Vladimir S AU - Plascjak, Paul S AU - Goldman, Carolyn K AU - Janik, John E AU - Brechbiel, Martin W AU - Waldmann, Thomas A AD - Metabolism Branch and Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, PET Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892 Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 8444 EP - 8448 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 20 SN - 0027-8424, 0027-8424 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - CD30 antigen KW - Animal models KW - Survival KW - Cancer KW - Tumor necrosis factor receptors KW - Models KW - Leukemia KW - Antibodies KW - Lymphoma KW - F 06915:Cancer Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19664105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Effective+therapy+of+murine+models+of+human+leukemia+and+lymphoma+with+radiolabeled+anti-CD30+antibody%2C+HeFi-1&rft.au=Zhang%2C+Meili%3BYao%2C+Zhengsheng%3BPatel%2C+Hiral%3BGarmestani%2C+Kayhan%3BZhang%2C+Zhuo%3BTalanov%2C+Vladimir+S%3BPlascjak%2C+Paul+S%3BGoldman%2C+Carolyn+K%3BJanik%2C+John+E%3BBrechbiel%2C+Martin+W%3BWaldmann%2C+Thomas+A&rft.aulast=Zhang&rft.aufirst=Meili&rft.date=2007-05-01&rft.volume=104&rft.issue=20&rft.spage=8444&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Animal models; Survival; Leukemia; Lymphoma; Models; Antibodies; CD30 antigen; Tumor necrosis factor receptors; Cancer ER - TY - JOUR T1 - Spectral Fluorescence Molecular Imaging of Lung Metastases Targeting HER2/neu AN - 19662715; 7417185 AB - PURPOSE: Surgical resection of pulmonary metastases is now a clinically accepted cancer therapy but its success depends on the accurate localization and removal of all tumor foci. To enhance the detection of pulmonary metastases during surgery, we developed an i.v. administered optical probe that uses a monoclonal antibody, Herceptin (trastuzumab), conjugated to a fluorophore, rhodamine green (RhodG), to specifically detect human epidermal growth factor receptor type 2 (HER2/neu)-expressing pulmonary lesions in an animal model of lung metastases. Experimental Design: Pulmonary metastases were induced by i.v. injection of gene-transfected murine embryonic fibroblasts (3T3) cells in a murine model to produce a mixed population of HER2+ and HER2- tumors. To image these tumors, an anti-HER2 (Herceptin) or a control (HUT) complementarity-determining region-grafted antibody was conjugated to RhodG and injected i.v. into mice. Spectral fluorescence imaging was done after thoracotomy and images were correlated with gross and microscopic pathology to assess sensitivity and specificity. RESULTS: HER2+ tumors injected with Herceptin-RhodG were more fluorescent than either HER2- tumors or HER2+ tumors injected with HUT-RhodG at all time points. The maximal fluorescence signal in HER2+ tumors injected with Herceptin-RhodG was observed at 1 day postinjection. The tumors fluoresced primarily at the rim and not their center, reflecting the binding-site barrier that is commonly seen with high-affinity antibodies. CONCLUSION: A HER2-targeted optical imaging probe shows the ability to specifically enhance HER2+ pulmonary metastases but not HER2- pulmonary metastases. The high sensitivity and specificity of this probe is encouraging for the development of antigen-targeted optical probes to assist in the resection of pulmonary metastases. JF - Clinical Cancer Research AU - Koyama, Yoshinori AU - Hama, Yukihiro AU - Urano, Yasuteru AU - Nguyen, Dao M AU - Choyke, Peter L AU - Kobayashi, Hisataka AD - Authors' Affiliations: Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, NIH Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 2936 EP - 2945 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 13 IS - 10 SN - 1078-0432, 1078-0432 KW - Oncogenes & Growth Factors Abstracts; Biotechnology and Bioengineering Abstracts KW - ErbB-2 protein KW - Animal models KW - Epidermal growth factor receptors KW - fluorophores KW - Metastases KW - Surgery KW - Embryo fibroblasts KW - Fluorescence KW - Monoclonal antibodies KW - Tumors KW - trastuzumab KW - imaging KW - Cancer KW - Lung KW - rhodamine KW - W 30910:Imaging KW - B 26600:Tyrosine Kinase Activity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19662715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Spectral+Fluorescence+Molecular+Imaging+of+Lung+Metastases+Targeting+HER2%2Fneu&rft.au=Koyama%2C+Yoshinori%3BHama%2C+Yukihiro%3BUrano%2C+Yasuteru%3BNguyen%2C+Dao+M%3BChoyke%2C+Peter+L%3BKobayashi%2C+Hisataka&rft.aulast=Koyama&rft.aufirst=Yoshinori&rft.date=2007-05-01&rft.volume=13&rft.issue=10&rft.spage=2936&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Lung; Tumors; Metastases; ErbB-2 protein; Fluorescence; imaging; Animal models; rhodamine; Embryo fibroblasts; Monoclonal antibodies; Cancer; Epidermal growth factor receptors; fluorophores; trastuzumab; Surgery ER - TY - JOUR T1 - Development of two novel benzoylphenylurea sulfur analogues and evidence that the microtubule-associated protein tau is predictive of their activity in pancreatic cancer AN - 19662414; 7420506 AB - In this work, we evaluated two lead compounds, referred to as SG410 and SG430, obtained from a screen of sulfur benzoylphenylurea analogues, against in vitro and in vivo models of pancreas cancer. Both drugs showed a similar mechanism of action profile, with SG410 being more potent as an inhibitor of tubulin assembly. We determined the best in vivo administration schedule and tested SG410 and SG430 in nine cases of a novel platform of direct pancreas cancer xenografts. Both compounds had antiproliferative activity in vitro in the low nanomolar range, but only SG410 showed significant activity in vivo. Administration of SG410 resulted in significant tumor growth delay in five of nine groups tested. In a direct comparison in three of the cases, SG410 was at least as efficacious as docetaxel. We also sought markers that would be predictive of the efficacy of these agents, and we found such a marker in microtubule-associated protein tau (MAPT). This protein enhances the assembly and stability of microtubules. In both the cell lines and the direct human xenografts, MAPT mRNA and protein levels correlated well. There was also a statistically significant inverse correlation between MAPT expression and sensitivity to the tested agents. In summary, the novel sulfur benzoylphenylurea SG410 showed activity inversely related to MAPT expression in a preclinical model of pancreatic cancer comparable with that observed with docetaxel, another microtubule-targeting agent. [Mol Cancer Ther 2007; 6(5):1509-16] JF - Molecular Cancer Therapeutics AU - Jimeno, Antonio AU - Hallur, Gurulingappa AU - Chan, Audrey AU - Zhang, Xiangfeng AU - Cusatis, George AU - Chan, Fonda AU - Shah, Preeti AU - Chen, Rongbing AU - Hamel, Ernest AU - Garrett-Mayer, Elizabeth AU - Khan, Saeed AU - Hidalgo, Manuel AD - Gastrointestinal Cancer Program, Chemical Therapeutics Program, and Division of Statistics, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine and Toxicology and Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute at Frederick, NIH Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 1509 EP - 1516 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 6 IS - 5 SN - 1535-7163, 1535-7163 KW - Biotechnology and Bioengineering Abstracts KW - Sulfur KW - Statistical analysis KW - Pancreatic cancer KW - Microtubule-associated proteins KW - Tumors KW - Xenografts KW - Tubulin KW - mRNA KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19662414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cancer+Therapeutics&rft.atitle=Development+of+two+novel+benzoylphenylurea+sulfur+analogues+and+evidence+that+the+microtubule-associated+protein+tau+is+predictive+of+their+activity+in+pancreatic+cancer&rft.au=Jimeno%2C+Antonio%3BHallur%2C+Gurulingappa%3BChan%2C+Audrey%3BZhang%2C+Xiangfeng%3BCusatis%2C+George%3BChan%2C+Fonda%3BShah%2C+Preeti%3BChen%2C+Rongbing%3BHamel%2C+Ernest%3BGarrett-Mayer%2C+Elizabeth%3BKhan%2C+Saeed%3BHidalgo%2C+Manuel&rft.aulast=Jimeno&rft.aufirst=Antonio&rft.date=2007-05-01&rft.volume=6&rft.issue=5&rft.spage=1509&rft.isbn=&rft.btitle=&rft.title=Molecular+Cancer+Therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Pancreatic cancer; Microtubule-associated proteins; Sulfur; Xenografts; Statistical analysis; Tumors; Tubulin; mRNA ER - TY - JOUR T1 - Production of Infectious Hepatitis C Virus of Various Genotypes in Cell Cultures AN - 19655599; 7408388 AB - A unique hepatitis C virus (HCV) strain JFH-1 has been shown to replicate efficiently in cell culture with production of infectious HCV. We previously developed a DNA expression system containing HCV cDNA flanked by two self-cleaving ribozymes to generate HCV particles in cell culture. In this study, we produced HCV particles of various genotypes, including 1a (H77), 1b (CG1b), and 2a (J6 and JFH-1), in the HCV-ribozyme system. The constructs also contain the secreted alkaline phosphatase gene to control for transfection efficiency and the effects of culture conditions. After transfection into the Huh7-derived cell line Huh7.5.1, continuous HCV replication and secretion were confirmed by the detection of HCV RNA and core antigen in the culture medium. HCV replication levels of strains H77, CG1b, and J6 were comparable, whereas the JFH-1 strain replicates at a substantially higher level than the other strains. To evaluate the infectivity in vitro, the culture medium of JFH-1-transfected cells was inoculated into naive Huh7.5.1 cells. HCV proteins were detected by immunofluorescence 3 days after inoculation. To evaluate the infectivity in vivo, the culture medium from HCV genotype 1b-transfected cells was inoculated into a chimpanzee and caused a typical course of HCV infection. The HCV 1b propagated in vitro and in vivo had sequences identical to those of the HCV genomic cDNA used for cell culture transfection. The development of culture systems for production of various HCV genotypes provides a valuable tool not only to study the replication and pathogenesis of HCV but also to screen for antivirals. JF - Journal of Virology AU - Kato, Takanobu AU - Matsumura, Takuya AU - Heller, Theo AU - Saito, Satoru AU - Sapp, Ronda K AU - Murthy, Krishna AU - Wakita, Takaji AU - Liang, TJake AD - Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892. Southwest Foundation for Biomedical Research, San Antonio, Texas 78227. Department of Microbiology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan Y1 - 2007/05/01/ PY - 2007 DA - 2007 May 01 SP - 4405 EP - 4411 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 81 IS - 9 SN - 0022-538X, 0022-538X KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Replication KW - Cell culture KW - Immunofluorescence KW - Genotypes KW - Infection KW - Pan troglodytes KW - Infectivity KW - Alkaline phosphatase KW - Hepatitis C virus KW - RNA KW - Transfection KW - Inoculation KW - genomics KW - Ribozymes KW - Core protein KW - V 22300:Methods KW - W 30945:Fermentation & Cell Culture KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19655599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Production+of+Infectious+Hepatitis+C+Virus+of+Various+Genotypes+in+Cell+Cultures&rft.au=Kato%2C+Takanobu%3BMatsumura%2C+Takuya%3BHeller%2C+Theo%3BSaito%2C+Satoru%3BSapp%2C+Ronda+K%3BMurthy%2C+Krishna%3BWakita%2C+Takaji%3BLiang%2C+TJake&rft.aulast=Kato&rft.aufirst=Takanobu&rft.date=2007-05-01&rft.volume=81&rft.issue=9&rft.spage=4405&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Replication; Cell culture; Genotypes; Immunofluorescence; Infection; Infectivity; Alkaline phosphatase; RNA; Transfection; Inoculation; genomics; Ribozymes; Core protein; Hepatitis C virus; Pan troglodytes ER - TY - JOUR T1 - Clinicoradiological features of tuberculous meningitis in patients over 50 years of age AN - 19654900; 7408115 AB - BACKGROUND: and aim: Tuberculous meningitis (TBM) is a debilitating form of CNS tuberculosis with a high morbidity and mortality in spite of treatment. The diagnosis is based on clinical, radiological and laboratory features. The classical CT features of basal exudates, hydrocephalus, infarcts and granulomas have been mostly reported in younger individuals. Our aim was to study imaging features of TB meningitis in adults over the age of 50 years. MATERIALS AND METHODS: Clinical, imaging and laboratory features of 53 adult patients over the age of 50 years (sixth to eighth decades) were studied retrospectively. Diagnosis of TBM was based on clinical and laboratory features. RESULTS: Imaging features were the conspicuous absence of typical features of TBM (ie, basal meningeal enhancement, hydrocephalus, infarcts/granulomas were seen in only a minority of patients). CONCLUSIONS: CT features of TBM in elderly patients were few, atypical and non-contributory for diagnosis, probably because of age related immune senescence. Strong clinical suspicion and correlation with laboratory findings is necessary for early diagnosis. JF - Journal of Neurology, Neurosurgery and Psychiatry AU - Srikanth, S G AU - Taly, A B AU - Nagarajan, K AU - Jayakumar, P N AU - Patil, S AD - Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, India. Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India. Department of Neuromicrobiology, National Institute of Mental Health and Neurosciences, Bangalore, India Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 536 EP - 538 PB - British Medical Association, BMA House Square Tavistock Square London WC1H 9JP UK, [mailto:info.web@bma.org.uk], [URL:http://www.bma.org.uk/] VL - 78 IS - 5 SN - 0022-3050, 0022-3050 KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Mortality KW - Central nervous system KW - Age KW - Mycobacterium KW - Granuloma KW - Neurosurgery KW - Morbidity KW - Meningitis KW - Exudates KW - Computed tomography KW - Geriatrics KW - Senescence KW - Tuberculosis KW - Hydrocephalus KW - J 02400:Human Diseases KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19654900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurology%2C+Neurosurgery+and+Psychiatry&rft.atitle=Clinicoradiological+features+of+tuberculous+meningitis+in+patients+over+50+years+of+age&rft.au=Srikanth%2C+S+G%3BTaly%2C+A+B%3BNagarajan%2C+K%3BJayakumar%2C+P+N%3BPatil%2C+S&rft.aulast=Srikanth&rft.aufirst=S&rft.date=2007-05-01&rft.volume=78&rft.issue=5&rft.spage=536&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurology%2C+Neurosurgery+and+Psychiatry&rft.issn=00223050&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Central nervous system; Mortality; Age; Granuloma; Neurosurgery; Morbidity; Meningitis; Exudates; Computed tomography; Geriatrics; Tuberculosis; Senescence; Hydrocephalus; Mycobacterium ER - TY - JOUR T1 - Teniae Coli-based Circumferential Localization System for CT Colonography: Feasibility Study AN - 19653226; 7409761 AB - This HIPAA-compliant study, with institutional review board approval and informed patient consent, was conducted to retrospectively develop a teniae coli-based circumferential localization method for guiding virtual colon navigation and colonic polyp registration. Colonic surfaces (n = 72) were depicted at computed tomographic (CT) colonography performed in 36 patients (26 men, 10 women; age range, 47-72 years) in the supine and prone positions. For 70 (97%) colonic surfaces, the tenia omentalis (TO), the most visible of the three teniae coli on a well-distended colonic surface, was manually extracted from the cecum to the descending colon. By virtually dissecting and flattening the colon along the TO, the authors developed a localization system involving 12 grid lines to estimate the circumferential positions of polyps. A sessile polyp would most likely (at 95% confidence level) be found within plus or minus 1.2 grid lines (one grid line equals 1/12 the circumference) with use of the proposed method. By orienting and positioning the virtual cameras with use of the new localization system, synchronized prone and supine navigation was achieved. The teniae coli are extractable landmarks, and the teniae coli-based circumferential localization system helps guide virtual navigation and polyp registration at CT colonography. Supplemental material: http://radiology.rsnajnls.org/cgi/content/full/243/2/551/DC1 [copy ] RSNA, 2007 JF - Radiology AU - Huang, Adam AU - Roy, Dave A AU - Summers, Ronald M AU - Franaszek, Marek AU - Petrick, Nicholas AU - Choi, JRichard AU - Pickhardt, Perry J AD - Diagnostic Radiology Department, Clinical Center, National Institutes of Health, 10 Center Dr, MSC 1182, Bldg 10, Room 1C351, Bethesda, MD 20892-1182 (A.H., D.A.R., R.M.S., M.F.) Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 551 EP - 560 PB - Radiological Society of North America, 820 Jorie Blvd. Oak Brook Illinois 60523-2251 USA VL - 243 IS - 2 SN - 0033-8419, 0033-8419 KW - Biotechnology and Bioengineering Abstracts KW - Colon KW - Computed tomography KW - Cameras KW - Cecum KW - Polyps KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19653226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Teniae+Coli-based+Circumferential+Localization+System+for+CT+Colonography%3A+Feasibility+Study&rft.au=Huang%2C+Adam%3BRoy%2C+Dave+A%3BSummers%2C+Ronald+M%3BFranaszek%2C+Marek%3BPetrick%2C+Nicholas%3BChoi%2C+JRichard%3BPickhardt%2C+Perry+J&rft.aulast=Huang&rft.aufirst=Adam&rft.date=2007-05-01&rft.volume=243&rft.issue=2&rft.spage=551&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Colon; Cameras; Computed tomography; Cecum; Polyps ER - TY - JOUR T1 - A novel synthetic analogue of a constituent of Isodon excisus inhibits transcription of CYP1A1, -1A2 and -1B1 by preventing activation of the aryl hydrocarbon receptor AN - 19652361; 7404899 AB - We investigated the effect of a novel synthetic analogue of a constituent from the Chinese medicinal herb Isodon excisus, 3-(3-methoxy-phenyl)-N-(3, 4, 5-trimethoxy-phenyl)-acrylamide (compound 343), on the carcinogen activation pathway mediated by the aryl hydrocarbon receptor (AhR) in human hepatoma HepG2 cells. We found that compound 343 inhibited the upregulation of cytochrome P-450 (CYP) enzyme activity in cells treated with the AhR ligands and potent carcinogens, dimethylbenz[a]anthracene (DMBA) or 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD). Compound 343 also inhibited the DMBA- or TCDD-induced increase in CYP1A1, -1A2 and -1B1 mRNA levels. Carcinogen-induced transcription of CYP genes was also suppressed by compound 343, as measured by a reporter gene controlled by the xenobiotic-responsive element (XRE). This was confirmed by measuring the amount of carcinogen-induced CYP1A1 heterogeneous nuclear RNA. Compound 343 blocked the DMBA- or TCDD-induced activation of the AhR DNA-binding capacity for the XRE, as measured by a chromatin immunoprecipitation assay. Compound 343 also inhibited CYP enzyme activity in microsomes isolated from DMBA- or TCDD-treated cells, as well as the activity of recombinant CYP1A1, -1A2 and -1B1, indicating that compound 343 directly inhibits CYP enzymes. These results indicate that compound 343 is both a potent inhibitor of carcinogen-induced CYP enzyme expression, as well as a direct inhibitor of CYP enzymes. JF - Carcinogenesis AU - Sienkiewicz, Pawel AU - Ciolino, Henry P AU - Leslie, Benjamin J AU - Hergenrother, Paul J AU - Singletary, Keith AU - Yeh, Grace Chao AD - Cellular Defense and Carcinogenesis Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702-1201, USA. Department of Chemistry, University of Illinois, Urbana, IL, USA. Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL, USA Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 1052 EP - 1057 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 28 IS - 5 SN - 0143-3334, 0143-3334 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Cytochromes KW - Chromatin KW - Carcinogens KW - Hepatoma KW - Herbal medicines KW - Microsomes KW - Immunoprecipitation KW - TCDD KW - Transcription KW - Enzymes KW - Reporter gene KW - Carcinogenesis KW - Cytochrome P450 KW - Aryl hydrocarbon receptors KW - N 14820:DNA Metabolism & Structure KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19652361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=A+novel+synthetic+analogue+of+a+constituent+of+Isodon+excisus+inhibits+transcription+of+CYP1A1%2C+-1A2+and+-1B1+by+preventing+activation+of+the+aryl+hydrocarbon+receptor&rft.au=Sienkiewicz%2C+Pawel%3BCiolino%2C+Henry+P%3BLeslie%2C+Benjamin+J%3BHergenrother%2C+Paul+J%3BSingletary%2C+Keith%3BYeh%2C+Grace+Chao&rft.aulast=Sienkiewicz&rft.aufirst=Pawel&rft.date=2007-05-01&rft.volume=28&rft.issue=5&rft.spage=1052&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Enzymes; Cytochrome P450; Aryl hydrocarbon receptors; Transcription; Carcinogens; TCDD; Immunoprecipitation; Chromatin; Carcinogenesis; Hepatoma; Cytochromes; Herbal medicines; Microsomes; Reporter gene ER - TY - JOUR T1 - In Vivo Modulation of a DnaJ Homolog, CbpA, by CbpM AN - 19651099; 7406692 AB - CbpA, an Escherichia coli DnaJ homolog, can function as a cochaperone for the DnaK/Hsp70 chaperone system, and its in vitro activity can be modulated by CbpM. We discovered that CbpM specifically inhibits the in vivo activity of CbpA, preventing it from functioning in cell growth and division. Furthermore, we have shown that CbpM interacts with CbpA in vivo during stationary phase, suggesting that the inhibition of activity is a result of the interaction. These results reveal that the activity of the E. coli DnaK system can be regulated in vivo by a specific inhibitor. JF - Journal of Bacteriology AU - Chenoweth, Matthew R AU - Trun, Nancy AU - Wickner, Sue AD - Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892. Department of Biological Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282 Y1 - 2007/05/01/ PY - 2007 DA - 2007 May 01 SP - 3635 EP - 3638 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 189 IS - 9 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - stationary phase KW - Hsp70 protein KW - Escherichia coli KW - DnaK protein KW - Chaperones KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19651099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=In+Vivo+Modulation+of+a+DnaJ+Homolog%2C+CbpA%2C+by+CbpM&rft.au=Chenoweth%2C+Matthew+R%3BTrun%2C+Nancy%3BWickner%2C+Sue&rft.aulast=Chenoweth&rft.aufirst=Matthew&rft.date=2007-05-01&rft.volume=189&rft.issue=9&rft.spage=3635&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - stationary phase; Hsp70 protein; DnaK protein; Chaperones; Escherichia coli ER - TY - JOUR T1 - Application of microarrays to identify and characterize genes involved in attachment dependence in HeLa cells AN - 19611003; 8586069 AB - The ability to modify cellular properties such as adhesion is of interest in the design and performance of biotechnology-related processes. The current study was undertaken in order to evaluate the effectiveness of modulating cellular adhesion in HeLa cells from a genomics perspective. Using DNA microarrays, differences in gene expression between two phenotypically distinct, anchorage-dependent and anchorage- independent, HeLa cell lines were identified. With the aid of several statistical methods and an extensive literature search, two genes were selected as potential targets for further study: siat7e and lama4. Subsequently, experiments were carried out to investigate the effects of siat7e and lama4 separately, on adhesion in HeLa cells by altering their expression in vivo. Decreasing the expression of siat7e, a type II membrane glycosylating sialyltransferase, in anchorage-independent HeLa cells using short interfering RNA (siRNA) resulted in greater aggregation (i.e. clumping) and morphological changes as compared to untreated anchorage-independent HeLa cells. Similar effects were seen in anchorage-independent HeLa cells when the expression of lama4 which encodes laminin alpha 4, a member of the laminin family of glycoproteins, was enhanced as compared to untreated anchorage-independent HeLa cells. Using a shear flow chamber, an attachment assay was developed; illustrating either increased expression of siat7e or decreased expression of lama4 in anchorage-dependent HeLa cells reduced cellular adhesion. Collectively, the results of this study are consistent with the roles siat7e and lama4 play in adhesion processes in vivo and indicate modifying the expression of either gene can influence adhesion in HeLa cells. The strategy of applying bioinformatics techniques to characterize and manipulate phenotypic behaviors is a powerful tool for altering the properties of various cell lines for desired biotechnology objectives. JF - Metabolic Engineering AU - Jaluria, Pratik AU - Betenbaugh, Michael AU - Konstantopoulos, Konstantinos AU - Frank, Bryan AU - Shiloach, Joseph AD - Department of Chemical and Biomolecular Engineering, Johns Hopkins University Baltimore, MD 21218, USA, yossi@nih.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 241 EP - 251 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 9 IS - 3 SN - 1096-7176, 1096-7176 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - HeLa KW - Laminin KW - Sialyltransferase KW - Cellular adhesion KW - Sialic acid KW - Aggregation KW - Genomics KW - Statistics KW - siRNA KW - metabolic engineering KW - Bioinformatics KW - genomics KW - Glycoproteins KW - DNA microarrays KW - Neolactotetraosylceramide alpha -2,3-sialyltransferase KW - G 07730:Development & Cell Cycle KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19611003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolic+Engineering&rft.atitle=Application+of+microarrays+to+identify+and+characterize+genes+involved+in+attachment+dependence+in+HeLa+cells&rft.au=Jaluria%2C+Pratik%3BBetenbaugh%2C+Michael%3BKonstantopoulos%2C+Konstantinos%3BFrank%2C+Bryan%3BShiloach%2C+Joseph&rft.aulast=Jaluria&rft.aufirst=Pratik&rft.date=2007-05-01&rft.volume=9&rft.issue=3&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Metabolic+Engineering&rft.issn=10967176&rft_id=info:doi/10.1016%2Fj.ymben.2006.12.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Laminin; Statistics; siRNA; metabolic engineering; Glycoproteins; genomics; Bioinformatics; DNA microarrays; Neolactotetraosylceramide alpha -2,3-sialyltransferase DO - http://dx.doi.org/10.1016/j.ymben.2006.12.001 ER - TY - JOUR T1 - Gram-positive three-component antimicrobial peptide-sensing system AN - 19524781; 7464592 AB - To survive during colonization or infection of the human body, microorganisms must circumvent mechanisms of innate host defense. Antimicrobial peptides represent a key component of innate host defense, especially in phagocytes and on epithelial surfaces. However, it is not known how the clinically important group of Gram-positive bacteria sense antimicrobial peptides to coordinate a directed defensive response. By determining the genome-wide gene regulatory response to human beta -defensin 3 in the nosocomial pathogen Staphylococcus epidermidis, we discovered an antimicrobial peptide sensor system that controls major specific resistance mechanisms of Gram-positive bacteria and is unrelated to the Gram-negative PhoP/PhoQ system. It contains a classical two-component signal transducer and an unusual third protein, all of which are indispensable for signal transduction and antimicrobial peptide resistance. Furthermore, our data indicate that a very short, extracellular loop with a high density of negative charges in the sensor protein is responsible for antimicrobial peptide binding and the observed specificity for cationic antimicrobial peptides. Our study shows that Gram-positive bacteria have developed an efficient and unique way of controlling resistance mechanisms to antimicrobial peptides, which may provide a promising target for antimicrobial drug development. JF - Proceedings of the National Academy of Sciences, USA AU - Li, Min AU - Lai, Yuping AU - Villaruz, Amer E AU - Cha, David J AU - Sturdevant, Daniel E AU - Otto, Michael AD - Laboratory of Human Bacterial Pathogenesis and Research and Technology Branch, Research Technologies Section, Genomics Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840 Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 9469 EP - 9474 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 22 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Data processing KW - Defensive behavior KW - Gram-positive bacteria KW - Drug development KW - Pathogens KW - Infection KW - Colonization KW - Defensins KW - cationic antimicrobial peptides KW - Phagocytes KW - Microorganisms KW - Staphylococcus epidermidis KW - Antimicrobial peptides KW - Signal transduction KW - A 01340:Antibiotics & Antimicrobials KW - N 14845:Miscellaneous KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19524781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Gram-positive+three-component+antimicrobial+peptide-sensing+system&rft.au=Li%2C+Min%3BLai%2C+Yuping%3BVillaruz%2C+Amer+E%3BCha%2C+David+J%3BSturdevant%2C+Daniel+E%3BOtto%2C+Michael&rft.aulast=Li&rft.aufirst=Min&rft.date=2007-05-01&rft.volume=104&rft.issue=22&rft.spage=9469&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Data processing; Gram-positive bacteria; Defensive behavior; Drug development; Pathogens; Infection; Colonization; Defensins; cationic antimicrobial peptides; Phagocytes; Microorganisms; Antimicrobial peptides; Signal transduction; Staphylococcus epidermidis ER - TY - JOUR T1 - Pesticides and other agricultural factors associated with self-reported farmer's lung among farm residents in the Agricultural Health Study AN - 19521616; 7409048 AB - BACKGROUND: Farmer's lung, or hypersensitivity pneumonitis, is an important contributor to respiratory morbidity among farmers. METHODS: Using the 1993-7 enrolment data from the Agricultural Health Study, we conducted a cross-sectional study of occupational risk factors for farmer's lung among similar to 50 000 farmers and farm spouses in Iowa and North Carolina using hierarchical logistic regression controlling for age, state, and smoking status. Participants provided information on agricultural exposures, demographic characteristics, and medical history via self-administered questionnaires. Approximately 2% of farmers (n = 481) and 0.2% of spouses (n = 51) reported doctor-diagnosed farmer's lung during their lifetime. We assessed farmers and spouses separately due to different information on occupational exposure history. Only pesticide exposures represented lifetime exposure history, all other farm exposures represented current activities at enrolment. RESULTS: Among farmers, handling silage (OR = 1.41, 95% CI 1.10 to 1.82), high pesticide exposure events (OR = 1.75, 95% CI 1.39 to 2.21), and ever use of organochlorine (OR = 1.34, 95% CI 1.04 to 1.74) and carbamate pesticides (OR = 1.32, 95% CI 1.03 to 1.68) were associated with farmer's lung in mutually-adjusted models. The insecticides DDT, lindane, and aldicarb were positively associated with farmer's lung among farmers. Current animal exposures, while not statistically significant, were positively associated with farmer's lung, particularly for poultry houses (OR = 1.55, 95% CI 0.93 to 2.58) and dairy cattle (OR = 1.28, 95% CI 0.86 to 1.89). The occupational data were more limited for spouses; however, we saw similar associations for dairy cattle (OR = 1.50, 95% CI 0.72 to 3.14) and organochlorine pesticides (OR = 1.29, 95% CI 0.64 to 2.59). CONCLUSION: While historic farm exposures may contribute to the observed associations with pesticides, these results suggest that organochlorine and carbamate pesticides should be further evaluated as potential risk factors for farmer's lung. JF - Occupational and Environmental Medicine AU - Hoppin, Jane A AU - Umbach, David M AU - Kullman, Greg J AU - Henneberger, Paul K AU - London, Stephanie J AU - Alavanja, Michael C R AU - Sandler, Dale P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 334 EP - 341 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 64 IS - 5 SN - 1351-0711, 1351-0711 KW - Risk Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts; Pollution Abstracts KW - demography KW - USA, North Carolina KW - Historical account KW - Poultry KW - Organochlorine compounds KW - Farms KW - poultry KW - Housing KW - Statistical analysis KW - Respiratory diseases KW - Morbidity KW - Models KW - Demography KW - Smoking KW - Hypersensitivity KW - Insecticides KW - farms KW - Pneumonitis KW - Risk factors KW - silage KW - Occupational exposure KW - Inventories KW - Farmer's lung KW - Pesticides (organochlorine) KW - Aldicarb KW - Lindane KW - Pesticides (carbamates) KW - Silage KW - hypersensitivity KW - Cattle KW - Dairies KW - USA, Iowa KW - Lung KW - Pesticides KW - DDT KW - Residential areas KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19521616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Pesticides+and+other+agricultural+factors+associated+with+self-reported+farmer%27s+lung+among+farm+residents+in+the+Agricultural+Health+Study&rft.au=Hoppin%2C+Jane+A%3BUmbach%2C+David+M%3BKullman%2C+Greg+J%3BHenneberger%2C+Paul+K%3BLondon%2C+Stephanie+J%3BAlavanja%2C+Michael+C+R%3BSandler%2C+Dale+P&rft.aulast=Hoppin&rft.aufirst=Jane&rft.date=2007-05-01&rft.volume=64&rft.issue=5&rft.spage=334&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Inventories; Poultry; Farms; Organochlorine compounds; Farmer's lung; Statistical analysis; Aldicarb; Pesticides (organochlorine); Lindane; Pesticides (carbamates); Morbidity; Models; Silage; Demography; Smoking; Dairies; Hypersensitivity; Insecticides; Risk factors; Pneumonitis; DDT; Pesticides; Occupational exposure; demography; Historical account; Housing; poultry; Respiratory diseases; hypersensitivity; Cattle; Lung; farms; Residential areas; silage; USA, North Carolina; USA, Iowa ER - TY - JOUR T1 - Phototoxicity in Human Retinal Pigment Epithelial Cells Promoted by Hypericin, a Component of St. John's Wort AN - 19467158; 8003183 AB - St. John's wort (SJW), an over-the-counter antidepressant, contains hypericin, which absorbs light in the UV and visible ranges. In vivo studies have determined that hypericin is phototoxic to skin and our previous in vitro studies with lens tissues have determined that it is potentially phototoxic to the human lens. To determine if hypericin might also be phototoxic to the human retina, we exposed human retinal pigment epithelial (hRPE) cells to 10 super(-7) to 10 super(-5) M hypericin. Fluorescence emission detected from the cells ( lambda sub(ex) = 488 nm; lambda sub(em) = 505 nm) confirmed hypericin uptake by human RPE. Neither hypericin exposure alone nor visible light exposure alone reduced cell viability. However when irradiated with 0.7 J cm super(-2) of visible light ( lambda > 400 nm) there was loss of cell viability as measured by MTS and lactate dehydrogenase assays. The presence of hypericin in irradiated hRPE cells significantly changed the redox equilibrium of glutathione and a decrease in the activity of glutathione reductase. Increased lipid peroxidation as measured by the thiobarbituric acid reactive substances assay correlated to hypericin concentration in hRPE cells and visible light radiation. Thus, ingested SJW is potentially phototoxic to the retina and could contribute to retinal or early macular degeneration. JF - Photochemistry and Photobiology AU - Wielgus, Albert R AU - Chignell, Colin F AU - Miller, David S AU - Houten, Ben Van AU - Meyer, Joel AU - Hu, Dan-Ning AU - Roberts, Joan E AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC, jroberts@fordham.edu Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 706 EP - 713 PB - Allen Press, Inc., 810 East Tenth St. VL - 83 IS - 3 SN - 0031-8655, 0031-8655 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - glutathione reductase KW - thiobarbituric acid KW - Fluorescence KW - Skin KW - Macular degeneration KW - Retina KW - Hypericin KW - Eye lens KW - Lipid peroxidation KW - Light effects KW - L-Lactate dehydrogenase KW - Phototoxicity KW - Antidepressants KW - retinal pigment epithelium KW - U.V. radiation KW - Pigments KW - X 24310:Pharmaceuticals KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19467158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Photochemistry+and+Photobiology&rft.atitle=Phototoxicity+in+Human+Retinal+Pigment+Epithelial+Cells+Promoted+by+Hypericin%2C+a+Component+of+St.+John%27s+Wort&rft.au=Wielgus%2C+Albert+R%3BChignell%2C+Colin+F%3BMiller%2C+David+S%3BHouten%2C+Ben+Van%3BMeyer%2C+Joel%3BHu%2C+Dan-Ning%3BRoberts%2C+Joan+E&rft.aulast=Wielgus&rft.aufirst=Albert&rft.date=2007-05-01&rft.volume=83&rft.issue=3&rft.spage=706&rft.isbn=&rft.btitle=&rft.title=Photochemistry+and+Photobiology&rft.issn=00318655&rft_id=info:doi/10.1562%2F2006-08-09-RA-1001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - thiobarbituric acid; glutathione reductase; Skin; Fluorescence; Retina; Macular degeneration; Hypericin; Eye lens; Lipid peroxidation; L-Lactate dehydrogenase; Light effects; Phototoxicity; retinal pigment epithelium; Antidepressants; U.V. radiation; Pigments DO - http://dx.doi.org/10.1562/2006-08-09-RA-1001 ER - TY - JOUR T1 - Why is Kaposi's sarcoma-associated herpesvirus not ubiquitous in the human population? AN - 1017958564; 16580145 AB - Kaposi's sarcoma-associated herpesvirus (KSHV), a gamma -herpesvirus, is the causative agent of Kaposi's sarcoma. While the incidence of Kaposi's sarcoma may be explained by the differences in the prevalence of KSHV, there is currently no explanation for the variation of KSHV prevalence in different geographic locations and populations. This review summarizes the current understanding of KSHV transmission and aims to provide insight into how KHSV may be transmitted and maintained in the human population. JF - Future Virology AU - Bagni, Rachel AU - Whitby, Denise AD - AIDS Vaccine Program, Viral Oncology Section, SAIC-Frederick, NCI-Frederick, Frederick, MD 21702, USA, whitbyd@ncifcrf.gov Y1 - 2007/05// PY - 2007 DA - May 2007 SP - 243 EP - 246 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB United Kingdom VL - 2 IS - 3 SN - 1746-0794, 1746-0794 KW - Sustainability Science Abstracts; Virology & AIDS Abstracts KW - Human populations KW - Kaposi's sarcoma KW - Reviews KW - Sarcoma KW - Human herpesvirus 8 KW - Kaposi's sarcoma-associated herpesvirus KW - M3 1010:Issues in Sustainable Development KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1017958564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Future+Virology&rft.atitle=Why+is+Kaposi%27s+sarcoma-associated+herpesvirus+not+ubiquitous+in+the+human+population%3F&rft.au=Bagni%2C+Rachel%3BWhitby%2C+Denise&rft.aulast=Bagni&rft.aufirst=Rachel&rft.date=2007-05-01&rft.volume=2&rft.issue=3&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Future+Virology&rft.issn=17460794&rft_id=info:doi/10.2217%2F17460794.2.3.243 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-05-01 N1 - Number of references - 51 N1 - Last updated - 2013-01-11 N1 - SubjectsTermNotLitGenreText - Kaposi's sarcoma; Reviews; Human populations; Sarcoma; Human herpesvirus 8; Kaposi's sarcoma-associated herpesvirus DO - http://dx.doi.org/10.2217/17460794.2.3.243 ER -